# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- VCBS PF13517.1 KOO20783.1 - 1.5e-119 390.4 149.7 1.3e-13 51.0 3.9 12.4 1 1 11 12 12 12 12 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO20783.1 - 1.7e-67 221.6 118.6 1.1e-05 24.9 1.3 13.5 13 0 0 13 13 13 13 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO20783.1 - 3.6e-21 75.3 55.6 0.41 10.0 0.1 13.2 1 1 12 13 13 13 13 Insecticide toxin TcdB middle/N-terminal region GCC2_GCC3 PF07699.8 KOO20783.1 - 5.2e-17 61.1 75.3 1.4e-07 30.9 0.5 9.8 3 1 7 10 10 10 6 GCC2 and GCC3 DUF4384 PF14326.1 KOO20783.1 - 2.4e-07 30.4 1.8 39 4.1 0.0 9.9 6 4 6 13 13 13 0 Domain of unknown function (DUF4384) Glyco_transf_56 PF07429.6 KOO20783.1 - 0.31 9.9 3.1 41 2.9 0.0 5.3 10 0 0 10 10 10 0 4-alpha-L-fucosyltransferase glycosyl transferase group 56 NCD3G PF07562.9 KOO20783.1 - 6.1 6.6 52.9 0.029 14.0 2.3 8.2 6 2 1 8 8 8 0 Nine Cysteines Domain of family 3 GPCR Ank_2 PF12796.2 KOO20785.1 - 9.9e-23 80.2 1.3 5e-17 62.0 0.4 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO20785.1 - 1.9e-16 58.9 0.6 2.2e-06 27.2 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat PDZ PF00595.19 KOO20785.1 - 2.8e-16 59.4 0.0 2.8e-07 30.6 0.0 2.6 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) Ank_5 PF13857.1 KOO20785.1 - 1.5e-14 53.6 0.6 7.1e-08 32.4 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO20785.1 - 1.3e-13 51.0 0.2 3e-06 27.5 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) PDZ_2 PF13180.1 KOO20785.1 - 5.4e-12 45.4 0.1 8.2e-05 22.4 0.0 2.5 2 0 0 2 2 2 2 PDZ domain Ank_3 PF13606.1 KOO20785.1 - 3.9e-10 38.9 0.1 0.0021 18.0 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Tricorn_PDZ PF14685.1 KOO20785.1 - 1.8e-08 34.0 0.1 0.0069 16.1 0.0 2.8 2 0 0 2 2 2 2 Tricorn protease PDZ domain GTP_EFTU_D2 PF03144.20 KOO20785.1 - 0.17 12.0 0.1 29 4.8 0.0 3.1 3 0 0 3 3 3 0 Elongation factor Tu domain 2 EF-hand_1 PF00036.27 KOO20786.1 - 2.5e-18 63.9 0.7 2.5e-05 23.2 0.0 4.7 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.1 KOO20786.1 - 1.3e-17 63.1 2.2 8.9e-07 28.4 0.0 4.8 3 2 2 5 5 5 3 EF-hand domain pair EF-hand_7 PF13499.1 KOO20786.1 - 4.3e-17 62.0 0.6 2.5e-10 40.3 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO20786.1 - 1.4e-16 58.7 0.5 0.00022 20.8 0.0 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO20786.1 - 6.6e-11 41.0 0.9 0.0033 16.6 0.1 3.9 3 0 0 3 3 3 3 EF hand EF-hand_9 PF14658.1 KOO20786.1 - 9.6e-06 25.4 0.1 0.017 15.0 0.0 3.5 2 1 1 3 3 3 1 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO20786.1 - 0.0035 17.3 1.0 1.6 8.8 0.0 3.4 2 2 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO20786.1 - 0.0036 16.9 0.2 7.5 6.3 0.0 3.5 2 1 1 3 3 3 2 EF hand Transpeptidase PF00905.17 KOO20787.1 - 0.18 10.7 0.1 12 4.7 0.0 4.1 4 3 2 6 6 6 0 Penicillin binding protein transpeptidase domain DUF2316 PF10078.4 KOO20787.1 - 0.41 10.6 1.6 8.5 6.4 0.1 3.8 4 2 1 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2316) PhyH PF05721.8 KOO20790.1 - 4.3e-08 33.4 0.2 3.3e-05 24.0 0.1 2.3 2 0 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) DUF1883 PF08980.5 KOO20790.1 - 0.061 12.8 0.0 0.34 10.4 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF1883) Filamin PF00630.14 KOO20791.1 - 2.5e-30 105.0 0.2 2e-06 28.2 0.0 5.3 4 1 1 5 5 5 5 Filamin/ABP280 repeat EIF4E-T PF10477.4 KOO20792.1 - 0.087 11.6 4.0 1.9 7.2 0.0 2.3 2 0 0 2 2 2 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Josephin PF02099.12 KOO20793.1 - 1.4e-05 24.7 0.5 3.9e-05 23.3 0.3 1.8 2 1 0 2 2 2 1 Josephin TPR_16 PF13432.1 KOO20794.1 - 4.4e-10 39.9 8.4 1.9e-05 25.2 0.6 4.6 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO20794.1 - 1.4e-07 31.4 1.6 0.04 14.5 0.3 5.2 2 1 3 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO20794.1 - 4.4e-07 29.3 9.2 0.05 13.5 0.3 4.8 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 KOO20794.1 - 9.1e-07 28.4 2.7 0.0055 16.3 0.1 2.7 2 0 0 2 2 2 2 TPR repeat TPR_19 PF14559.1 KOO20794.1 - 1.1e-06 28.9 5.0 0.097 13.0 0.3 4.3 2 1 2 4 4 4 1 Tetratricopeptide repeat YfiO PF13525.1 KOO20794.1 - 0.0036 16.8 2.2 0.067 12.6 0.4 2.1 1 1 1 2 2 2 1 Outer membrane lipoprotein TPR_8 PF13181.1 KOO20794.1 - 0.0071 16.0 2.9 19 5.3 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat NARP1 PF12569.3 KOO20794.1 - 0.018 13.8 3.5 0.039 12.7 0.1 2.0 1 1 1 2 2 2 0 NMDA receptor-regulated protein 1 TPR_9 PF13371.1 KOO20794.1 - 0.023 14.5 3.9 2.2 8.2 0.8 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat ST7 PF04184.7 KOO20794.1 - 0.033 12.4 0.2 0.044 12.0 0.1 1.2 1 0 0 1 1 1 0 ST7 protein DUF964 PF06133.6 KOO20794.1 - 0.033 14.1 1.4 0.058 13.4 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF964) Apc3 PF12895.2 KOO20794.1 - 0.055 13.6 3.7 0.13 12.4 1.8 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.1 KOO20794.1 - 0.062 13.1 6.9 0.12 12.2 0.1 3.6 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.23 KOO20794.1 - 0.072 12.7 7.5 6.3 6.5 0.4 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO20794.1 - 0.45 11.0 3.4 52 4.6 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO20794.1 - 0.47 10.3 3.6 57 3.8 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat CLASP_N PF12348.3 KOO20795.1 - 0.12 11.6 0.1 0.32 10.3 0.0 1.7 2 0 0 2 2 2 0 CLASP N terminal Seipin PF06775.9 KOO20796.1 - 2.7e-27 95.5 0.0 4.9e-27 94.7 0.0 1.3 1 1 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) FA_desaturase PF00487.19 KOO20797.1 - 4.9e-16 58.9 21.9 4.9e-16 58.9 15.2 1.8 1 1 1 2 2 2 1 Fatty acid desaturase Ank_2 PF12796.2 KOO20798.1 - 4.7e-24 84.5 0.0 9.7e-11 41.8 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO20798.1 - 1.1e-19 69.9 3.5 1.4e-09 37.9 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO20798.1 - 1.5e-17 62.4 3.2 8.9e-08 31.5 0.0 3.9 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 KOO20798.1 - 6.8e-13 48.7 3.2 0.00035 20.9 0.4 4.2 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO20798.1 - 3.2e-11 42.3 0.1 0.017 15.3 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat tRNA-synt_1 PF00133.17 KOO20799.1 - 1.9e-63 214.4 0.2 7.2e-39 133.2 0.0 4.0 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.1 KOO20799.1 - 8.9e-57 191.3 0.0 1.4e-56 190.7 0.0 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.6 KOO20799.1 - 2.2e-24 85.8 0.0 4.6e-16 58.4 0.0 2.6 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.8 KOO20799.1 - 5.1e-17 62.0 0.1 1.5e-16 60.4 0.1 1.7 1 1 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.14 KOO20799.1 - 4.1e-05 22.8 0.0 0.0039 16.3 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1d PF00750.14 KOO20799.1 - 0.0068 15.2 0.0 0.012 14.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (R) DUF1242 PF06842.7 KOO20800.1 - 9.9e-13 47.3 0.2 1.5e-12 46.7 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) DUF2069 PF09842.4 KOO20800.1 - 0.067 13.1 0.4 0.17 11.8 0.0 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2069) Glucosamine_iso PF01182.15 KOO20802.1 - 7.4e-23 81.3 0.0 1.1e-22 80.7 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase IFT57 PF10498.4 KOO20803.1 - 3.9e-94 315.3 0.0 5.3e-94 314.9 0.0 1.2 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Transcrip_act PF04949.8 KOO20803.1 - 0.00063 19.4 1.9 0.0015 18.1 0.9 2.0 1 1 0 1 1 1 1 Transcriptional activator DUF948 PF06103.6 KOO20803.1 - 0.0032 17.2 0.2 0.053 13.3 0.4 2.5 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF948) Reo_sigmaC PF04582.7 KOO20803.1 - 0.0043 16.2 2.6 0.0073 15.5 1.4 1.5 1 1 0 1 1 1 1 Reovirus sigma C capsid protein NPV_P10 PF05531.7 KOO20803.1 - 0.0097 16.1 3.6 0.019 15.2 1.7 2.1 1 1 0 1 1 1 1 Nucleopolyhedrovirus P10 protein Snapin_Pallidin PF14712.1 KOO20803.1 - 0.02 15.2 4.4 0.033 14.4 1.9 2.3 1 1 1 2 2 2 0 Snapin/Pallidin DUF4208 PF13907.1 KOO20803.1 - 0.076 13.2 3.1 0.12 12.6 0.6 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4208) LOH1CR12 PF10158.4 KOO20803.1 - 0.21 11.4 2.9 0.29 10.9 1.3 1.8 1 1 1 2 2 2 0 Tumour suppressor protein IncA PF04156.9 KOO20803.1 - 0.3 10.6 8.1 1.8 8.1 5.4 2.3 2 2 0 2 2 2 0 IncA protein FliD_N PF02465.13 KOO20803.1 - 0.62 10.4 6.3 0.76 10.1 2.1 2.7 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Syntaxin_2 PF14523.1 KOO20803.1 - 0.73 9.9 9.0 0.043 13.8 1.4 2.5 3 1 0 3 3 3 0 Syntaxin-like protein TPR_MLP1_2 PF07926.7 KOO20803.1 - 2 8.1 11.0 13 5.5 7.6 2.3 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Activator-TraM PF11657.3 KOO20804.1 - 0.033 13.6 0.0 0.058 12.8 0.0 1.4 1 0 0 1 1 1 0 Transcriptional activator TraM Ion_trans PF00520.26 KOO20805.1 - 4.4e-05 22.8 16.7 0.0025 17.0 11.6 2.3 1 1 0 1 1 1 1 Ion transport protein WW PF00397.21 KOO20805.1 - 0.0014 18.4 2.2 0.0014 18.4 1.5 2.2 2 0 0 2 2 2 1 WW domain Epimerase PF01370.16 KOO20806.1 - 4.7e-23 81.8 0.0 6.2e-23 81.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 KOO20806.1 - 5.2e-17 62.4 1.3 8.1e-17 61.8 0.9 1.3 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 KOO20806.1 - 3.7e-14 52.1 0.0 4.9e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 KOO20806.1 - 4.6e-08 32.2 1.6 5.7e-06 25.4 0.0 2.3 1 1 1 2 2 2 2 Male sterility protein NmrA PF05368.8 KOO20806.1 - 3.2e-06 26.5 0.7 8.9e-05 21.8 0.3 2.1 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.20 KOO20806.1 - 0.0096 15.8 5.9 0.31 10.9 0.0 3.1 3 0 0 3 3 3 2 short chain dehydrogenase Polysacc_synt_2 PF02719.10 KOO20806.1 - 0.029 13.2 2.6 0.38 9.6 1.8 2.3 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein KR PF08659.5 KOO20806.1 - 0.037 13.7 0.2 0.037 13.7 0.1 2.8 3 0 0 3 3 3 0 KR domain Ank_2 PF12796.2 KOO20807.1 - 1.1e-39 134.6 1.9 2.8e-21 75.6 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO20807.1 - 8.5e-34 115.3 2.6 2.2e-10 40.7 0.0 4.1 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.25 KOO20807.1 - 1.6e-33 112.8 2.4 5.6e-08 32.2 0.1 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.1 KOO20807.1 - 4.9e-29 97.4 2.0 2.4e-06 27.2 0.0 5.7 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.1 KOO20807.1 - 6.6e-27 92.9 4.6 1.2e-10 41.2 0.1 5.4 1 1 4 5 5 5 5 Ankyrin repeats (many copies) ADAM_CR PF08516.7 KOO20807.1 - 0.019 15.0 0.7 0.037 14.0 0.5 1.5 1 0 0 1 1 1 0 ADAM cysteine-rich PDZ PF00595.19 KOO20808.1 - 1.1e-07 31.8 0.0 1.8e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO20808.1 - 2.9e-07 30.2 0.0 4.9e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 PDZ domain UPF0118 PF01594.11 KOO20809.1 - 3.3e-34 118.3 33.1 1.5e-23 83.2 12.5 3.2 3 0 0 3 3 3 3 Domain of unknown function DUF20 DUF4404 PF14357.1 KOO20809.1 - 2.5 8.5 6.6 0.6 10.5 1.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Sugar_tr PF00083.19 KOO20810.1 - 8.5e-71 238.8 6.0 2.8e-54 184.3 0.6 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 KOO20810.1 - 1.1e-24 86.8 25.8 1.4e-23 83.1 17.8 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 KOO20810.1 - 1.6e-09 36.5 3.7 4.3e-08 31.8 1.0 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.1 KOO20810.1 - 0.24 9.7 15.8 0.01 14.2 3.3 2.7 3 0 0 3 3 3 0 MFS/sugar transport protein Phage_holin_2 PF04550.7 KOO20810.1 - 5.9 7.0 11.8 3.4 7.8 1.0 3.4 2 1 1 3 3 3 0 Phage holin family 2 EamA PF00892.15 KOO20812.1 - 2.7e-11 43.5 14.3 4.5e-06 26.7 0.8 2.2 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.11 KOO20812.1 - 5e-11 42.4 10.8 5e-11 42.4 7.5 2.0 2 0 0 2 2 2 1 Triose-phosphate Transporter family Form-deh_trans PF09163.6 KOO20812.1 - 0.017 14.5 0.5 0.017 14.5 0.4 2.0 2 0 0 2 2 2 0 Formate dehydrogenase N, transmembrane DUF1469 PF07332.6 KOO20812.1 - 0.058 13.1 0.2 0.058 13.1 0.2 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF1469) Ank_2 PF12796.2 KOO20813.1 - 1.4e-39 134.2 2.7 3.1e-21 75.4 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO20813.1 - 5.7e-34 115.8 3.1 2e-10 40.9 0.0 3.9 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.25 KOO20813.1 - 1.4e-33 113.0 2.9 6.2e-08 32.0 0.1 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.1 KOO20813.1 - 4.8e-29 97.5 2.0 2.1e-06 27.3 0.0 5.3 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.1 KOO20813.1 - 4.3e-26 90.3 4.2 3.2e-10 39.9 0.1 5.4 1 1 4 5 5 5 5 Ankyrin repeats (many copies) ADAM_CR PF08516.7 KOO20813.1 - 0.024 14.6 1.4 0.053 13.5 0.9 1.6 1 1 0 1 1 1 0 ADAM cysteine-rich DHDPS PF00701.17 KOO20814.1 - 1e-87 293.4 0.0 1.4e-87 292.9 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Saccharop_dh_N PF04455.7 KOO20814.1 - 3.3e-12 46.4 0.2 9e-12 45.0 0.2 1.7 1 1 0 1 1 1 1 LOR/SDH bifunctional enzyme conserved region ACT_5 PF13710.1 KOO20814.1 - 0.13 12.0 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 ACT domain Filamin PF00630.14 KOO20815.1 - 1.4e-19 70.5 0.0 1.2e-11 44.9 0.0 3.9 3 1 0 3 3 3 3 Filamin/ABP280 repeat Neurexophilin PF06312.7 KOO20815.1 - 0.00016 21.0 0.0 0.00028 20.2 0.0 1.3 1 0 0 1 1 1 1 Neurexophilin Big_3_4 PF13754.1 KOO20815.1 - 0.011 15.9 0.1 0.78 10.1 0.1 2.8 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) Big_3 PF07523.7 KOO20815.1 - 0.039 14.0 0.1 0.13 12.3 0.1 1.9 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) Big_1 PF02369.11 KOO20815.1 - 0.19 11.6 5.5 0.71 9.8 0.1 3.4 3 1 0 4 4 4 0 Bacterial Ig-like domain (group 1) K-cyclin_vir_C PF09080.5 KOO20817.1 - 0.91 9.7 5.9 0.14 12.3 1.1 2.0 2 0 0 2 2 2 0 K cyclin, C terminal Methyltransf_PK PF05891.7 KOO20818.1 - 3.2e-37 127.9 0.0 4.9e-37 127.3 0.0 1.3 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Peptidase_M14 PF00246.19 KOO20818.1 - 8.1e-27 94.5 0.0 1.4e-26 93.7 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase Methyltransf_18 PF12847.2 KOO20818.1 - 1.5e-08 35.2 0.0 3.4e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO20818.1 - 1.1e-06 29.0 0.0 2.6e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO20818.1 - 1.1e-06 28.4 0.0 2.1e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO20818.1 - 2.4e-05 24.7 0.0 9.2e-05 22.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 KOO20818.1 - 0.00013 21.2 0.0 0.00029 20.0 0.0 1.5 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_25 PF13649.1 KOO20818.1 - 0.00028 21.1 0.0 0.00057 20.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO20818.1 - 0.0052 16.8 0.2 0.016 15.2 0.1 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.1 KOO20818.1 - 0.07 13.9 0.0 0.21 12.4 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain ADIP PF11559.3 KOO20819.1 - 0.0045 16.9 0.7 0.0056 16.5 0.5 1.1 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding DivIC PF04977.10 KOO20819.1 - 0.0074 15.7 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 Septum formation initiator WXG100 PF06013.7 KOO20819.1 - 0.058 13.3 0.1 0.074 13.0 0.1 1.2 1 0 0 1 1 1 0 Proteins of 100 residues with WXG OTCace_N PF02729.16 KOO20819.1 - 0.06 13.0 0.2 0.073 12.7 0.1 1.3 1 1 0 1 1 1 0 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain UDPGP PF01704.13 KOO20820.1 - 2.1e-45 155.0 0.0 2.9e-45 154.5 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase WD40 PF00400.27 KOO20820.1 - 2.4e-35 119.1 9.0 8.9e-13 47.5 0.4 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat PD40 PF07676.7 KOO20820.1 - 4.8e-06 26.1 0.5 3.3 7.4 0.0 3.8 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat NTP_transf_3 PF12804.2 KOO20820.1 - 0.00013 22.1 0.1 0.00049 20.2 0.0 2.0 1 0 0 1 1 1 1 MobA-like NTP transferase domain DEAD PF00270.24 KOO20821.1 - 3.3e-14 52.7 0.0 9.4e-14 51.2 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO20821.1 - 2.4e-12 46.5 0.0 5.2e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain T4SS-DNA_transf PF02534.9 KOO20821.1 - 0.34 9.4 0.0 0.57 8.6 0.0 1.3 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer Spc7 PF08317.6 KOO20823.1 - 1.7e-05 23.6 8.0 1.7e-05 23.6 5.5 1.4 2 0 0 2 2 2 1 Spc7 kinetochore protein WEMBL PF05701.6 KOO20823.1 - 4.3e-05 22.1 15.2 4.3e-05 22.1 10.6 2.1 1 1 0 1 1 1 1 Weak chloroplast movement under blue light CENP-F_leu_zip PF10473.4 KOO20823.1 - 0.0011 18.8 7.5 0.0011 18.8 5.2 2.7 2 1 1 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.7 KOO20823.1 - 0.01 15.5 15.0 0.01 15.5 10.4 2.5 2 2 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF874 PF05917.6 KOO20823.1 - 0.062 12.1 2.4 0.091 11.6 1.6 1.2 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) FliJ PF02050.11 KOO20823.1 - 0.23 11.5 26.2 0.58 10.2 6.4 4.1 3 1 1 4 4 4 0 Flagellar FliJ protein THOC7 PF05615.8 KOO20823.1 - 0.4 10.9 15.7 5.5 7.2 7.8 3.1 2 1 1 3 3 3 0 Tho complex subunit 7 DUF1664 PF07889.7 KOO20823.1 - 0.41 10.4 3.4 1 9.1 0.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Cast PF10174.4 KOO20823.1 - 0.63 8.0 24.7 1.9 6.4 17.1 1.7 1 1 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone BAR_2 PF10455.4 KOO20823.1 - 1.1 8.1 10.8 23 3.7 7.5 2.8 1 1 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking DUF2564 PF10819.3 KOO20823.1 - 1.4 9.0 18.8 4 7.6 2.6 3.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2564) GAS PF13851.1 KOO20823.1 - 1.8 7.7 15.9 0.32 10.1 2.5 2.6 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding COG2 PF06148.6 KOO20823.1 - 2.5 7.9 8.8 9.4 6.1 1.5 3.1 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Macoilin PF09726.4 KOO20823.1 - 3.2 5.9 11.8 4.3 5.4 8.2 1.2 1 0 0 1 1 1 0 Transmembrane protein AAA_13 PF13166.1 KOO20823.1 - 3.9 5.8 9.9 3.5 5.9 1.5 2.2 1 1 0 1 1 1 0 AAA domain Bap31 PF05529.7 KOO20823.1 - 5.9 6.2 5.9 88 2.4 4.1 2.3 1 1 0 1 1 1 0 B-cell receptor-associated protein 31-like IncA PF04156.9 KOO20823.1 - 8 6.0 26.7 2 8.0 15.0 2.3 2 1 0 2 2 2 0 IncA protein DUF4201 PF13870.1 KOO20823.1 - 8 5.8 16.6 0.065 12.6 2.7 2.8 2 2 1 3 3 3 0 Domain of unknown function (DUF4201) DnaJ PF00226.26 KOO20824.1 - 2.8e-23 81.3 0.3 5.6e-23 80.4 0.2 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.1 KOO20824.1 - 3.3e-22 78.7 3.0 1.3e-21 76.8 0.6 2.2 2 0 0 2 2 2 1 X-domain of DnaJ-containing SAP PF02037.22 KOO20824.1 - 0.00047 19.5 0.0 0.001 18.5 0.0 1.5 1 0 0 1 1 1 1 SAP domain ATG_C PF09333.6 KOO20824.1 - 0.0027 17.8 1.4 0.0081 16.2 0.5 2.1 2 0 0 2 2 2 1 ATG C terminal domain Mito_fiss_reg PF05308.6 KOO20824.1 - 0.041 13.2 0.1 0.073 12.4 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator Arfaptin PF06456.8 KOO20824.1 - 0.083 12.2 1.8 0.29 10.4 0.3 2.0 2 0 0 2 2 2 0 Arfaptin-like domain zf-C3HC4_3 PF13920.1 KOO20825.1 - 3.6e-14 52.1 8.7 6.5e-14 51.3 6.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Tmemb_185A PF10269.4 KOO20825.1 - 2.5e-13 50.2 14.5 1.8e-07 31.0 0.9 2.2 1 1 0 2 2 2 2 Transmembrane Fragile-X-F protein zf-C3HC4_2 PF13923.1 KOO20825.1 - 2.1e-09 37.2 10.5 4.4e-09 36.2 7.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO20825.1 - 8.1e-08 31.7 7.8 1.9e-07 30.6 5.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO20825.1 - 2.6e-05 23.9 9.9 5.5e-05 22.9 6.8 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 KOO20825.1 - 4.3e-05 23.1 9.7 8.5e-05 22.1 6.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.1 KOO20825.1 - 0.17 11.4 5.2 0.85 9.2 3.6 2.0 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.1 KOO20825.1 - 2.5 7.7 9.5 5.9 6.5 6.6 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF1644 PF07800.7 KOO20825.1 - 3 7.6 7.5 1.5 8.6 1.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1644) EF-hand_1 PF00036.27 KOO20826.1 - 4.7e-19 66.1 8.8 8.4e-08 30.9 0.2 3.5 3 1 1 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO20826.1 - 4.1e-17 61.5 5.1 1.5e-12 46.9 0.1 3.2 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO20826.1 - 1.8e-15 55.3 4.1 1.2e-06 27.8 0.1 3.8 3 1 1 4 4 4 2 EF-hand domain EF-hand_7 PF13499.1 KOO20826.1 - 9.4e-15 54.5 2.3 2.2e-12 46.9 0.2 2.4 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO20826.1 - 3.2e-10 38.8 10.8 5.7e-05 22.2 0.1 3.7 4 2 0 4 4 4 2 EF hand EF-hand_9 PF14658.1 KOO20826.1 - 6.5e-07 29.1 0.4 1.4e-06 28.1 0.0 1.8 2 1 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.2 KOO20826.1 - 2.8e-05 23.7 0.3 8.9e-05 22.1 0.1 1.9 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO20826.1 - 0.057 13.4 0.1 0.11 12.5 0.0 1.6 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Imm42 PF15601.1 KOO20826.1 - 0.12 11.7 0.1 0.2 11.0 0.1 1.4 1 0 0 1 1 1 0 Immunity protein 42 Aminotran_3 PF00202.16 KOO20827.1 - 7.2e-105 350.5 0.0 1.2e-104 349.8 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-III Orn_Arg_deC_N PF02784.11 KOO20827.1 - 3.7e-57 193.4 0.0 5.8e-57 192.7 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.17 KOO20827.1 - 7.2e-24 83.7 0.0 1.4e-23 82.8 0.0 1.5 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain PDZ_2 PF13180.1 KOO20827.1 - 5.1e-16 58.3 0.2 0.00034 20.4 0.0 4.3 4 1 0 4 4 4 3 PDZ domain PDZ PF00595.19 KOO20827.1 - 5.4e-16 58.5 0.6 4.3e-07 30.0 0.0 4.5 4 0 0 4 4 4 3 PDZ domain (Also known as DHR or GLGF) DUF563 PF04577.9 KOO20827.1 - 4.9e-13 49.4 0.0 8.8e-13 48.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Tricorn_PDZ PF14685.1 KOO20827.1 - 0.00041 20.0 0.0 4.8 7.0 0.0 3.8 3 0 0 3 3 3 2 Tricorn protease PDZ domain ABC_tran PF00005.22 KOO20828.1 - 1.3e-34 119.4 0.0 2.2e-34 118.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 KOO20828.1 - 2.1e-23 83.1 8.4 2.8e-23 82.7 5.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_16 PF13191.1 KOO20828.1 - 3e-05 24.0 1.3 3e-05 24.0 0.9 2.0 2 1 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.14 KOO20828.1 - 6.9e-05 22.1 5.4 0.00027 20.2 0.1 2.8 2 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.4 KOO20828.1 - 0.0001 21.0 0.0 0.001 17.7 0.0 2.1 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_17 PF13207.1 KOO20828.1 - 0.00016 22.4 0.0 0.00036 21.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.1 KOO20828.1 - 0.00029 20.8 0.0 0.061 13.2 0.0 2.1 1 1 0 2 2 2 1 AAA domain AAA_22 PF13401.1 KOO20828.1 - 0.0033 17.5 0.7 0.037 14.1 0.2 2.6 2 1 0 2 2 2 1 AAA domain APS_kinase PF01583.15 KOO20828.1 - 0.0043 16.7 0.0 0.0095 15.6 0.0 1.6 1 0 0 1 1 1 1 Adenylylsulphate kinase Zeta_toxin PF06414.7 KOO20828.1 - 0.0049 15.9 0.0 0.0094 15.0 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_29 PF13555.1 KOO20828.1 - 0.0096 15.4 0.1 0.026 14.0 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_10 PF12846.2 KOO20828.1 - 0.011 15.2 0.4 5 6.4 0.1 2.5 2 0 0 2 2 2 0 AAA-like domain AAA_19 PF13245.1 KOO20828.1 - 0.012 15.3 1.2 0.051 13.3 0.0 2.6 2 0 0 2 2 2 0 Part of AAA domain AAA_18 PF13238.1 KOO20828.1 - 0.018 15.3 0.0 0.034 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 KOO20828.1 - 0.028 13.8 2.2 0.32 10.3 1.6 2.4 1 1 0 1 1 1 0 AAA domain SbcCD_C PF13558.1 KOO20828.1 - 0.047 13.6 0.6 0.25 11.3 0.4 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit CPT PF07931.7 KOO20828.1 - 0.05 13.2 0.0 0.17 11.4 0.0 2.0 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Ribosomal_L9_C PF03948.9 KOO20828.1 - 0.053 13.6 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L9, C-terminal domain AAA_33 PF13671.1 KOO20828.1 - 0.078 12.8 0.2 0.32 10.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 KOO20828.1 - 0.096 11.8 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_5 PF07728.9 KOO20828.1 - 0.1 12.3 0.1 0.85 9.3 0.0 2.5 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) TPR_10 PF13374.1 KOO20830.1 - 2.2e-36 122.7 54.9 3.1e-07 30.1 0.9 9.4 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_12 PF13424.1 KOO20830.1 - 6.7e-33 112.4 52.5 4.5e-11 42.5 0.3 7.6 3 3 6 9 9 9 8 Tetratricopeptide repeat DUF218 PF02698.12 KOO20830.1 - 5.4e-21 74.7 0.2 1.8e-20 72.9 0.0 2.0 2 0 0 2 2 2 1 DUF218 domain TPR_16 PF13432.1 KOO20830.1 - 5.3e-09 36.5 30.7 0.00012 22.6 4.1 6.0 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.1 KOO20830.1 - 2.5e-05 23.8 15.7 0.0058 16.2 0.3 4.9 4 1 1 5 5 5 3 TPR repeat RINGv PF12906.2 KOO20830.1 - 0.00012 22.0 7.5 0.00012 22.0 5.2 2.1 2 0 0 2 2 2 1 RING-variant domain TPR_7 PF13176.1 KOO20830.1 - 0.0016 18.0 17.0 1.6 8.7 0.1 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO20830.1 - 0.0073 15.8 11.5 8.9 6.1 0.3 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO20830.1 - 0.015 15.4 5.8 4.8 7.6 0.0 5.4 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO20830.1 - 0.23 11.4 20.8 5.2 7.2 0.3 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat YTH PF04146.10 KOO20831.1 - 2.5e-46 156.7 0.1 3.3e-46 156.3 0.1 1.1 1 0 0 1 1 1 1 YT521-B-like domain Aminotran_5 PF00266.14 KOO20832.1 - 1.1e-26 93.4 0.0 3.6e-26 91.7 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class-V ATP_bind_3 PF01171.15 KOO20832.1 - 5.5e-15 55.3 0.0 1.2e-14 54.2 0.0 1.5 1 0 0 1 1 1 1 PP-loop family Aminotran_1_2 PF00155.16 KOO20832.1 - 0.18 10.7 0.0 0.28 10.0 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II EF-hand_7 PF13499.1 KOO20834.1 - 9.3e-49 163.4 10.5 1.6e-11 44.1 0.0 5.6 3 2 3 6 6 6 5 EF-hand domain pair EF-hand_1 PF00036.27 KOO20834.1 - 6.7e-48 156.3 8.7 9.5e-05 21.4 0.0 9.6 6 3 3 9 9 9 9 EF hand EF-hand_6 PF13405.1 KOO20834.1 - 3.5e-44 144.7 16.6 2.8e-05 23.6 0.0 9.8 6 3 3 9 9 9 9 EF-hand domain EF-hand_5 PF13202.1 KOO20834.1 - 1.9e-36 121.7 16.8 0.00031 19.9 0.0 9.6 8 1 1 9 9 9 8 EF hand EF-hand_8 PF13833.1 KOO20834.1 - 7.1e-33 112.0 3.9 9.6e-08 31.5 0.0 6.5 5 2 1 6 6 6 5 EF-hand domain pair EF-hand_9 PF14658.1 KOO20834.1 - 3.5e-06 26.8 0.1 1.2 9.0 0.0 4.9 4 1 1 5 5 5 1 EF-hand domain EF-hand_2 PF09068.6 KOO20834.1 - 3.2e-05 23.9 0.0 2.3 8.3 0.0 5.9 5 1 1 6 6 6 2 EF hand SPARC_Ca_bdg PF10591.4 KOO20834.1 - 4.2e-05 23.5 0.1 1.5 8.8 0.0 4.6 4 1 1 5 5 5 1 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.8 KOO20834.1 - 0.0085 15.6 0.0 39 3.9 0.0 3.6 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0154) DUF1664 PF07889.7 KOO20834.1 - 0.017 14.9 1.7 0.097 12.4 1.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Toprim_2 PF13155.1 KOO20834.1 - 0.019 15.3 1.1 53 4.2 0.0 4.6 1 1 3 4 4 4 0 Toprim-like Caleosin PF05042.8 KOO20834.1 - 0.064 12.8 0.0 2.5 7.6 0.0 3.2 3 1 1 4 4 4 0 Caleosin related protein TBPIP PF07106.8 KOO20834.1 - 0.084 12.4 2.2 0.17 11.4 1.5 1.4 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Telomere_Sde2_2 PF13297.1 KOO20834.1 - 0.31 10.3 2.6 3.1 7.1 0.0 3.7 4 0 0 4 4 4 0 Telomere stability C-terminal DnaJ PF00226.26 KOO20835.1 - 2e-10 40.2 0.2 1.3e-08 34.4 0.0 3.5 3 0 0 3 3 3 1 DnaJ domain TPR_7 PF13176.1 KOO20835.1 - 0.001 18.7 8.7 4 7.4 0.0 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO20835.1 - 0.0033 16.9 10.9 7.6 6.3 0.0 5.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 KOO20835.1 - 0.0081 15.7 21.4 4.3 7.0 0.2 5.8 4 2 0 5 5 5 4 TPR repeat TPR_19 PF14559.1 KOO20835.1 - 0.013 15.7 0.3 0.013 15.7 0.2 6.0 6 2 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO20835.1 - 0.076 12.9 0.2 0.076 12.9 0.2 6.7 7 0 0 7 7 7 0 Tetratricopeptide repeat Hist_deacetyl PF00850.14 KOO20836.1 - 3.3e-88 295.9 0.5 4.7e-88 295.4 0.3 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Ank_2 PF12796.2 KOO20837.1 - 2.2e-28 98.4 5.5 3.4e-15 56.1 0.7 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) EF-hand_1 PF00036.27 KOO20837.1 - 2.9e-15 54.3 3.7 3.1e-07 29.2 0.3 2.7 2 0 0 2 2 2 2 EF hand Ank PF00023.25 KOO20837.1 - 4.6e-15 54.5 1.3 3.5e-10 39.1 0.4 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOO20837.1 - 9.8e-14 51.4 2.2 1.9e-08 34.6 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) EF-hand_7 PF13499.1 KOO20837.1 - 1e-13 51.2 0.3 2.5e-13 49.9 0.2 1.7 1 0 0 1 1 1 1 EF-hand domain pair Ank_5 PF13857.1 KOO20837.1 - 3.7e-13 49.2 1.9 8.1e-09 35.4 0.4 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) EF-hand_5 PF13202.1 KOO20837.1 - 8.1e-12 43.9 2.8 3.1e-07 29.4 0.7 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO20837.1 - 2.3e-10 39.4 0.1 6.5e-06 25.5 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO20837.1 - 1.1e-09 37.7 3.8 2.8e-08 33.2 0.6 2.6 1 1 1 2 2 2 2 EF-hand domain pair Ank_3 PF13606.1 KOO20837.1 - 1.2e-09 37.4 0.9 5.3e-07 29.2 0.2 3.2 2 0 0 2 2 2 1 Ankyrin repeat ART PF01129.13 KOO20837.1 - 0.00015 20.9 0.0 0.00034 19.7 0.0 1.5 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase EF-hand_9 PF14658.1 KOO20837.1 - 0.00053 19.8 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain ADPrib_exo_Tox PF03496.9 KOO20837.1 - 0.0017 17.6 0.0 0.005 16.0 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme DnaJ PF00226.26 KOO20838.1 - 2.1e-22 78.5 0.6 3.8e-22 77.7 0.4 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 KOO20838.1 - 7.7e-16 57.7 0.0 1.1e-06 28.4 0.0 3.5 3 1 0 3 3 3 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 KOO20838.1 - 7.5e-08 32.3 7.1 7.5e-08 32.3 4.9 2.1 2 0 0 2 2 2 1 DnaJ central domain zf-IS66 PF13005.2 KOO20838.1 - 0.44 10.5 3.9 3.2 7.8 0.2 2.6 2 0 0 2 2 2 0 zinc-finger binding domain of transposase IS66 Cullin PF00888.17 KOO20839.1 - 8.2e-161 536.4 0.3 1.1e-160 536.1 0.2 1.1 1 0 0 1 1 1 1 Cullin family Sod_Fe_C PF02777.13 KOO20839.1 - 9.5e-39 131.5 0.1 2.6e-38 130.0 0.0 1.7 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Gar1 PF04410.9 KOO20839.1 - 2.9e-36 124.2 0.0 7.3e-36 122.9 0.0 1.7 2 0 0 2 2 2 1 Gar1/Naf1 RNA binding region Cullin_Nedd8 PF10557.4 KOO20839.1 - 1.3e-26 92.1 0.2 3.2e-26 90.9 0.2 1.7 1 0 0 1 1 1 1 Cullin protein neddylation domain Sod_Fe_N PF00081.17 KOO20839.1 - 4.5e-24 84.5 1.1 1.1e-23 83.2 0.7 1.7 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain WD40 PF00400.27 KOO20840.1 - 1.2e-17 63.0 4.9 4.8e-06 26.2 0.2 3.9 4 0 0 4 4 4 3 WD domain, G-beta repeat EF-hand_1 PF00036.27 KOO20841.1 - 1.4e-08 33.3 6.0 0.027 13.7 0.0 4.5 3 1 1 4 4 4 3 EF hand EF-hand_7 PF13499.1 KOO20841.1 - 1.6e-08 34.5 0.4 0.00027 20.9 0.5 3.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO20841.1 - 4.8e-07 29.1 2.6 1 9.4 1.4 4.5 3 1 1 4 4 4 3 EF-hand domain EF-hand_8 PF13833.1 KOO20841.1 - 4.3e-05 23.0 2.5 0.014 15.0 0.5 3.7 1 1 2 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO20841.1 - 0.0015 17.7 3.4 0.98 8.8 0.0 4.4 4 1 0 4 4 4 2 EF hand UPF0061 PF02696.9 KOO20842.1 - 6.4e-54 183.0 0.0 2.2e-31 108.7 0.0 2.4 2 1 1 3 3 3 2 Uncharacterized ACR, YdiU/UPF0061 family ShK PF01549.19 KOO20842.1 - 1.5e-05 25.2 2.5 3.2e-05 24.1 1.7 1.5 1 0 0 1 1 1 1 ShK domain-like Choline_transpo PF04515.7 KOO20844.1 - 1.4e-61 208.1 21.6 1.4e-61 208.1 14.9 1.6 2 0 0 2 2 2 1 Plasma-membrane choline transporter Myosin_head PF00063.16 KOO20845.1 - 3.6e-142 474.8 0.0 5.2e-142 474.2 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) CBS PF00571.23 KOO20845.1 - 7.4e-08 32.0 3.1 0.00046 19.9 0.0 3.7 4 0 0 4 4 4 2 CBS domain PB1 PF00564.19 KOO20845.1 - 0.049 13.2 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 PB1 domain TraG_N PF07916.6 KOO20845.1 - 0.053 11.9 0.0 0.082 11.3 0.0 1.2 1 0 0 1 1 1 0 TraG-like protein, N-terminal region Zeta_toxin PF06414.7 KOO20845.1 - 0.13 11.3 0.0 0.25 10.3 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin T2SE PF00437.15 KOO20845.1 - 0.16 10.8 0.3 0.48 9.2 0.1 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein Sigma54_activat PF00158.21 KOO20845.1 - 0.16 11.3 0.0 0.3 10.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain IMS PF00817.15 KOO20846.1 - 1.2e-37 128.9 0.0 2.1e-37 128.2 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.3 KOO20846.1 - 9.6e-17 61.1 0.0 1.8e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.3 KOO20846.1 - 0.0078 16.2 0.0 0.036 14.1 0.0 2.2 2 0 0 2 2 2 1 IMS family HHH motif DUF1805 PF08827.6 KOO20846.1 - 0.011 15.5 0.0 0.041 13.6 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) Cdd1 PF11731.3 KOO20846.1 - 0.014 15.3 0.0 0.06 13.2 0.0 2.0 2 0 0 2 2 2 0 Pathogenicity locus PMSR PF01625.16 KOO20849.1 - 6.5e-29 100.8 0.4 1e-28 100.1 0.3 1.2 1 1 0 1 1 1 1 Peptide methionine sulfoxide reductase Pkinase PF00069.20 KOO20850.1 - 4.5e-46 157.0 0.0 6.2e-46 156.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO20850.1 - 1e-25 90.2 0.0 2.1e-25 89.3 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase IPK PF03770.11 KOO20850.1 - 5e-15 55.6 0.0 9.1e-15 54.8 0.0 1.4 1 0 0 1 1 1 1 Inositol polyphosphate kinase Kinase-like PF14531.1 KOO20850.1 - 0.00053 19.0 0.0 0.00085 18.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO20850.1 - 0.011 15.5 0.3 2.7 7.6 0.0 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family FA_desaturase PF00487.19 KOO20851.1 - 5.7e-06 25.9 3.9 7.3e-06 25.6 2.7 1.1 1 0 0 1 1 1 1 Fatty acid desaturase OTU PF02338.14 KOO20852.1 - 1.8e-09 38.2 0.0 4.1e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 OTU-like cysteine protease UBA PF00627.26 KOO20852.1 - 0.016 15.0 0.1 0.038 13.8 0.0 1.7 1 0 0 1 1 1 0 UBA/TS-N domain Aminotran_1_2 PF00155.16 KOO20853.1 - 3e-84 283.0 0.0 3.4e-84 282.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DUF1974 PF09317.6 KOO20854.1 - 1.1e-39 136.5 3.2 4.2e-39 134.6 2.3 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF1974) Acyl-CoA_dh_1 PF00441.19 KOO20854.1 - 1.8e-14 54.0 0.8 1.8e-14 54.0 0.6 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 KOO20854.1 - 3.1e-14 53.5 0.1 1.2e-13 51.6 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain FAD_binding_3 PF01494.14 KOO20855.1 - 5.6e-21 74.9 1.3 2e-20 73.1 0.9 1.8 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 KOO20855.1 - 2.1e-06 27.6 0.7 6.3e-06 26.1 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOO20855.1 - 0.00017 20.6 1.1 0.0007 18.6 0.1 2.2 2 1 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.9 KOO20855.1 - 0.0032 16.0 0.0 0.0051 15.3 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.1 KOO20855.1 - 0.0072 16.4 0.1 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOO20855.1 - 0.014 15.7 0.0 0.034 14.5 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 KOO20855.1 - 0.05 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.7 KOO20855.1 - 0.062 12.2 0.6 0.13 11.1 0.0 1.8 3 0 0 3 3 3 0 Lycopene cyclase protein ApbA PF02558.11 KOO20855.1 - 0.086 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_7 PF13241.1 KOO20855.1 - 0.1 12.8 0.0 0.23 11.7 0.0 1.8 1 1 0 1 1 1 0 Putative NAD(P)-binding FMN_red PF03358.10 KOO20857.1 - 6.8e-06 25.6 0.1 1.8e-05 24.3 0.1 1.7 1 1 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.12 KOO20857.1 - 0.00053 19.5 0.0 0.0008 18.9 0.0 1.4 1 1 0 1 1 1 1 Flavodoxin-like fold DXP_synthase_N PF13292.1 KOO20858.1 - 1e-106 355.8 0.0 1.7e-105 351.8 0.0 2.1 2 0 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase Transket_pyr PF02779.19 KOO20858.1 - 6.3e-42 143.0 0.0 1.5e-41 141.8 0.0 1.6 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 KOO20858.1 - 1.2e-25 89.8 0.3 2.7e-25 88.7 0.0 1.8 2 0 0 2 2 2 1 Transketolase, C-terminal domain Transketolase_N PF00456.16 KOO20858.1 - 6.2e-07 28.5 0.0 0.18 10.5 0.0 3.2 3 0 0 3 3 3 3 Transketolase, thiamine diphosphate binding domain E1_dh PF00676.15 KOO20858.1 - 2.5e-06 26.4 0.1 4.7e-06 25.5 0.1 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.16 KOO20858.1 - 4.1e-06 26.4 0.2 1.5e-05 24.6 0.2 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain AAA_12 PF13087.1 KOO20859.1 - 2.5e-61 206.5 0.0 7.4e-61 205.0 0.0 1.8 3 0 0 3 3 3 1 AAA domain AAA_11 PF13086.1 KOO20859.1 - 1.2e-53 182.1 1.7 1.9e-53 181.4 1.2 1.3 1 0 0 1 1 1 1 AAA domain UPF1_Zn_bind PF09416.5 KOO20859.1 - 9.3e-48 161.6 1.5 1.3e-47 161.2 0.2 1.8 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_19 PF13245.1 KOO20859.1 - 2.1e-12 46.5 0.1 4.9e-12 45.4 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 KOO20859.1 - 2.7e-11 43.4 0.3 9.9e-10 38.3 0.2 2.3 1 1 0 1 1 1 1 AAA domain ResIII PF04851.10 KOO20859.1 - 3.8e-06 26.8 0.0 8.3e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.4 KOO20859.1 - 3.1e-05 23.1 3.3 4.2e-05 22.7 0.0 2.7 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.9 KOO20859.1 - 0.00056 19.5 0.0 0.0013 18.3 0.0 1.6 1 0 0 1 1 1 1 Helicase AAA_25 PF13481.1 KOO20859.1 - 0.00062 19.2 0.0 0.0011 18.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain DEAD PF00270.24 KOO20859.1 - 0.0024 17.3 0.1 0.0048 16.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase PhoH PF02562.11 KOO20859.1 - 0.004 16.4 0.1 0.0082 15.3 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein SRP54 PF00448.17 KOO20859.1 - 0.004 16.6 0.0 0.0066 15.9 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SNF2_N PF00176.18 KOO20859.1 - 0.0096 14.7 0.0 0.017 13.9 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Flavi_DEAD PF07652.9 KOO20859.1 - 0.015 15.0 0.1 0.027 14.2 0.1 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain NACHT PF05729.7 KOO20859.1 - 0.017 14.7 0.0 0.04 13.5 0.0 1.7 1 0 0 1 1 1 0 NACHT domain UvrD-helicase PF00580.16 KOO20859.1 - 0.053 12.8 0.5 0.28 10.4 0.0 2.3 3 1 1 4 4 4 0 UvrD/REP helicase N-terminal domain AAA_5 PF07728.9 KOO20859.1 - 0.059 13.0 0.0 0.34 10.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PIF1 PF05970.9 KOO20859.1 - 0.068 12.1 0.1 6.5 5.5 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase AAA_22 PF13401.1 KOO20859.1 - 0.091 12.9 0.0 0.22 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain KaiC PF06745.8 KOO20859.1 - 0.098 11.7 0.0 0.51 9.4 0.0 1.9 2 0 0 2 2 2 0 KaiC T2SE PF00437.15 KOO20859.1 - 0.2 10.5 0.0 0.33 9.8 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein Sec66 PF09802.4 KOO20860.1 - 5e-15 55.3 1.0 7.2e-15 54.8 0.7 1.2 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 GLTSCR1 PF15249.1 KOO20860.1 - 0.092 12.8 2.2 0.12 12.4 0.2 2.1 2 1 0 2 2 2 0 Glioma tumor suppressor candidate region Cmc1 PF08583.5 KOO20861.1 - 3e-05 23.6 13.7 0.0032 17.2 1.3 2.2 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.8 KOO20861.1 - 0.0018 18.1 7.9 0.0044 16.9 0.3 2.9 2 1 1 3 3 3 1 CHCH domain DUF3243 PF11588.3 KOO20861.1 - 0.09 12.7 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3243) COX6B PF02297.12 KOO20861.1 - 0.12 12.4 14.3 0.11 12.5 0.6 2.1 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb Ndufs5 PF10200.4 KOO20861.1 - 0.13 12.2 2.7 0.19 11.7 1.6 1.5 1 1 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa Pet191_N PF10203.4 KOO20861.1 - 0.82 9.7 13.4 1.1 9.3 4.1 3.0 1 1 2 3 3 3 0 Cytochrome c oxidase assembly protein PET191 UPF0203 PF05254.7 KOO20861.1 - 1.1 9.1 10.8 3.1 7.7 0.9 3.1 2 2 1 3 3 3 0 Uncharacterised protein family (UPF0203) UCR_hinge PF02320.11 KOO20861.1 - 1.4 8.9 10.9 1.9 8.4 1.4 2.9 1 1 2 3 3 3 0 Ubiquinol-cytochrome C reductase hinge protein COX17 PF05051.8 KOO20861.1 - 6.9 6.7 19.5 0.12 12.4 1.9 3.6 2 2 1 3 3 3 0 Cytochrome C oxidase copper chaperone (COX17) BTB_2 PF02214.17 KOO20863.1 - 1.1e-09 38.3 0.0 1.8e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Laminin_G_2 PF02210.19 KOO20864.1 - 0.00015 21.8 0.0 0.00055 19.9 0.0 2.0 2 0 0 2 2 2 1 Laminin G domain Laminin_G_1 PF00054.18 KOO20864.1 - 0.0097 15.9 0.0 0.024 14.6 0.0 1.7 1 0 0 1 1 1 1 Laminin G domain Laminin_G_3 PF13385.1 KOO20864.1 - 0.11 12.7 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily HECT PF00632.20 KOO20867.1 - 6.4e-46 156.9 0.0 1e-45 156.2 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Nramp PF01566.13 KOO20869.1 - 1e-36 126.5 25.4 1e-36 126.5 17.6 3.5 1 1 0 2 2 2 1 Natural resistance-associated macrophage protein SKG6 PF08693.5 KOO20869.1 - 0.059 12.7 0.1 0.059 12.7 0.0 3.3 3 0 0 3 3 3 0 Transmembrane alpha-helix domain Ion_trans_2 PF07885.11 KOO20869.1 - 6.1 6.6 8.7 0.43 10.3 0.1 3.4 4 0 0 4 4 4 0 Ion channel Calreticulin PF00262.13 KOO20870.1 - 0.00061 18.5 5.6 0.0013 17.4 1.4 2.1 2 0 0 2 2 2 1 Calreticulin family DAP10 PF07213.6 KOO20870.1 - 0.068 12.9 0.2 0.21 11.3 0.1 1.8 1 0 0 1 1 1 0 DAP10 membrane protein Spidroin_MaSp PF11260.3 KOO20870.1 - 0.19 11.7 3.7 1.2 9.2 0.3 2.9 3 0 0 3 3 3 0 Major ampullate spidroin 1 and 2 Daxx PF03344.10 KOO20871.1 - 8.4 4.7 16.8 10 4.4 11.6 1.1 1 0 0 1 1 1 0 Daxx Family Vps51 PF08700.6 KOO20872.1 - 5.6e-24 83.8 5.5 1.3e-23 82.5 1.2 3.1 3 0 0 3 3 3 1 Vps51/Vps67 Sec5 PF15469.1 KOO20872.1 - 7.9e-18 64.8 5.0 1.2e-17 64.2 0.3 2.5 2 1 0 2 2 2 1 Exocyst complex component Sec5 Dor1 PF04124.7 KOO20872.1 - 1.8e-12 46.3 3.5 1.8e-12 46.3 2.4 2.1 2 0 0 2 2 2 1 Dor1-like family COG2 PF06148.6 KOO20872.1 - 2.2e-06 27.5 2.6 2.2e-06 27.5 1.8 2.8 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps53_N PF04100.7 KOO20872.1 - 9e-05 21.4 2.2 9e-05 21.4 1.5 2.2 2 0 0 2 2 2 1 Vps53-like, N-terminal Zw10 PF06248.8 KOO20872.1 - 0.00058 18.1 2.4 0.00058 18.1 1.7 1.8 2 0 0 2 2 2 1 Centromere/kinetochore Zw10 DUF2450 PF10475.4 KOO20872.1 - 0.00064 18.7 2.9 0.00064 18.7 2.0 1.7 2 0 0 2 2 2 1 Protein of unknown function N-terminal domain (DUF2450) COG5 PF10392.4 KOO20872.1 - 0.0068 16.3 0.8 0.0068 16.3 0.6 2.8 2 1 0 2 2 2 1 Golgi transport complex subunit 5 Nsp1_C PF05064.8 KOO20872.1 - 0.039 13.5 4.1 0.3 10.7 0.5 2.5 2 0 0 2 2 2 0 Nsp1-like C-terminal region Enkurin PF13864.1 KOO20872.1 - 0.12 12.5 0.3 0.12 12.5 0.2 2.9 3 0 0 3 3 2 0 Calmodulin-binding V_ATPase_I PF01496.14 KOO20872.1 - 0.33 8.7 2.8 0.65 7.7 1.9 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fib_alpha PF08702.5 KOO20872.1 - 6.6 6.8 8.9 8.6 6.4 0.3 3.5 3 1 2 5 5 5 0 Fibrinogen alpha/beta chain family CENP-F_leu_zip PF10473.4 KOO20872.1 - 9.1 6.1 15.8 0.02 14.7 2.9 2.4 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HALZ PF02183.13 KOO20873.1 - 0.13 12.0 8.4 0.61 9.8 1.5 4.8 3 0 0 3 3 3 0 Homeobox associated leucine zipper Bromodomain PF00439.20 KOO20874.1 - 3.1e-23 81.5 0.0 3.8e-23 81.2 0.0 1.1 1 0 0 1 1 1 1 Bromodomain Nucleotid_trans PF03407.11 KOO20875.1 - 2.9e-30 105.6 0.0 5.7e-30 104.6 0.0 1.5 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Bax1-I PF01027.15 KOO20875.1 - 3e-28 98.8 6.3 5.2e-28 98.0 4.4 1.3 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Peptidase_S41 PF03572.13 KOO20875.1 - 0.0024 17.3 0.0 0.0042 16.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S41 O-FucT PF10250.4 KOO20875.1 - 0.11 11.6 0.2 0.17 10.9 0.2 1.2 1 0 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase Glyco_transf_34 PF05637.7 KOO20875.1 - 0.13 11.7 0.1 0.64 9.4 0.0 1.9 2 0 0 2 2 2 0 galactosyl transferase GMA12/MNN10 family LRR_6 PF13516.1 KOO20876.1 - 9.4e-23 77.6 17.4 0.0081 16.1 0.1 8.9 8 1 1 9 9 9 7 Leucine Rich repeat Ank_2 PF12796.2 KOO20876.1 - 3.7e-20 72.0 0.3 1.3e-13 51.0 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO20876.1 - 1.6e-17 62.3 1.0 4.5e-08 32.5 0.1 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.1 KOO20876.1 - 3.5e-16 59.2 0.8 2.4e-07 31.0 0.0 3.9 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO20876.1 - 8.7e-15 54.4 4.4 8.5e-09 35.3 0.1 4.2 2 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO20876.1 - 1.3e-13 49.7 0.4 0.00067 19.6 0.0 4.7 4 0 0 4 4 4 2 Ankyrin repeat LRR_1 PF00560.28 KOO20876.1 - 7e-09 34.5 7.0 2.4 8.5 0.1 7.5 7 1 0 7 7 7 3 Leucine Rich Repeat LRR_4 PF12799.2 KOO20876.1 - 6.3e-07 28.8 14.4 0.3 10.7 0.0 6.0 6 0 0 6 6 6 4 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO20876.1 - 1.7e-05 24.2 14.9 8.4 7.0 0.3 7.5 8 0 0 8 8 8 1 Leucine rich repeat LRR_8 PF13855.1 KOO20876.1 - 0.0068 16.1 16.4 16 5.3 2.1 6.4 3 2 1 4 4 4 0 Leucine rich repeat G_glu_transpept PF01019.16 KOO20876.1 - 0.057 11.9 1.3 0.13 10.6 0.9 1.5 1 0 0 1 1 1 0 Gamma-glutamyltranspeptidase zf-CDGSH PF09360.5 KOO20877.1 - 0.81 9.5 7.7 7.3 6.5 0.2 2.4 2 0 0 2 2 2 0 Iron-binding zinc finger CDGSH type Myosin_head PF00063.16 KOO20878.1 - 2.3e-203 677.0 0.0 4.1e-203 676.2 0.0 1.4 2 0 0 2 2 2 1 Myosin head (motor domain) EF-hand_1 PF00036.27 KOO20878.1 - 2.9e-19 66.8 1.8 7.5e-07 28.0 0.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO20878.1 - 1.2e-18 66.4 0.9 2.5e-06 26.9 0.0 4.0 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.1 KOO20878.1 - 8.2e-16 57.8 0.2 5.3e-10 39.2 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO20878.1 - 5.2e-13 47.6 5.9 3.6e-05 23.2 0.0 5.3 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.1 KOO20878.1 - 5.9e-10 38.0 5.1 0.00064 18.9 0.0 4.1 4 0 0 4 4 4 3 EF hand EF-hand_4 PF12763.2 KOO20878.1 - 5.9e-07 29.1 1.0 0.13 12.0 0.0 3.7 2 1 1 3 3 3 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO20878.1 - 0.0032 17.4 0.2 0.0032 17.4 0.1 2.7 2 1 1 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region Armet PF10208.4 KOO20878.1 - 0.0057 16.3 0.7 0.02 14.5 0.2 2.2 3 0 0 3 3 3 1 Degradation arginine-rich protein for mis-folding AAA_22 PF13401.1 KOO20878.1 - 0.017 15.2 0.1 0.083 13.0 0.1 2.2 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 KOO20878.1 - 2 8.7 4.1 1.9 8.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain PPR_2 PF13041.1 KOO20880.1 - 1.1e-22 79.7 0.0 1e-10 41.3 0.0 3.4 1 1 3 4 4 4 4 PPR repeat family PPR_1 PF12854.2 KOO20880.1 - 1.7e-19 69.0 0.1 2e-09 36.7 0.0 4.4 4 0 0 4 4 4 2 PPR repeat PPR PF01535.15 KOO20880.1 - 1.1e-16 59.5 0.2 6.7e-05 22.5 0.0 5.2 6 0 0 6 6 6 4 PPR repeat PPR_3 PF13812.1 KOO20880.1 - 3.4e-16 58.0 6.4 1.3e-06 28.1 0.0 6.4 6 1 1 7 7 7 2 Pentatricopeptide repeat domain Methyltransf_4 PF02390.12 KOO20880.1 - 1.3e-15 56.9 0.0 2.7e-15 55.9 0.0 1.4 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_26 PF13659.1 KOO20880.1 - 6.1e-07 29.4 0.1 6.1e-07 29.4 0.1 2.9 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO20880.1 - 0.0009 19.8 0.0 0.0023 18.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO20880.1 - 0.021 15.1 0.0 0.052 13.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 KOO20880.1 - 0.054 13.2 0.0 0.71 9.5 0.0 2.3 1 1 0 1 1 1 0 Methyltransferase domain TPR_12 PF13424.1 KOO20880.1 - 0.082 12.8 0.2 0.96 9.4 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Apc3 PF12895.2 KOO20880.1 - 0.11 12.6 0.0 0.97 9.6 0.0 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 KOO20880.1 - 0.11 13.1 12.2 17 6.4 0.0 5.1 4 2 1 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.9 KOO20880.1 - 0.24 11.9 5.9 5.2 7.8 0.1 3.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Aldo_ket_red PF00248.16 KOO20881.1 - 8.5e-50 169.1 0.0 5.6e-36 123.8 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family Sulfatase PF00884.18 KOO20882.1 - 4.2e-45 154.2 0.0 5.8e-45 153.7 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Nramp PF01566.13 KOO20882.1 - 3e-35 121.6 21.3 3.1e-34 118.3 14.8 2.0 1 1 0 1 1 1 1 Natural resistance-associated macrophage protein Sulfatase_C PF14707.1 KOO20882.1 - 0.0054 17.0 0.0 0.01 16.1 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase HAD_2 PF13419.1 KOO20883.1 - 3.4e-18 66.4 0.0 6.2e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOO20883.1 - 4.6e-17 63.1 2.6 1.1e-16 61.9 0.4 2.4 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO20883.1 - 5.9e-12 46.1 0.0 9.2e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOO20883.1 - 2.4e-07 30.3 0.1 5.6e-07 29.1 0.1 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.1 KOO20883.1 - 0.0026 17.6 0.0 0.083 12.7 0.0 2.4 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase EF-hand_1 PF00036.27 KOO20884.1 - 1.5e-09 36.4 0.0 0.00036 19.6 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO20884.1 - 9.9e-09 34.3 0.1 0.0083 15.9 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO20884.1 - 2.7e-08 33.8 0.0 4.7e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO20884.1 - 1.1e-07 30.8 0.4 0.016 14.5 0.1 2.8 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO20884.1 - 1.7e-05 24.3 0.0 9.2e-05 21.9 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO20884.1 - 0.065 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region HTH_24 PF13412.1 KOO20884.1 - 0.13 11.6 0.1 0.3 10.4 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding LRR_6 PF13516.1 KOO20885.1 - 1.1e-14 52.8 13.5 0.018 15.0 0.2 8.7 9 0 0 9 9 9 5 Leucine Rich repeat LRR_4 PF12799.2 KOO20885.1 - 2.8e-05 23.6 12.6 0.095 12.3 0.2 5.7 3 2 4 7 7 7 3 Leucine Rich repeats (2 copies) NACHT PF05729.7 KOO20885.1 - 0.00058 19.5 0.1 0.005 16.5 0.0 2.4 1 1 0 1 1 1 1 NACHT domain LRR_1 PF00560.28 KOO20885.1 - 0.0011 18.7 0.4 3.1 8.1 0.0 5.7 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_8 PF13855.1 KOO20885.1 - 0.031 14.0 5.4 5.8 6.7 0.2 5.1 3 2 2 5 5 5 0 Leucine rich repeat AAA_14 PF13173.1 KOO20885.1 - 0.049 13.5 0.0 0.43 10.4 0.0 2.4 1 1 0 2 2 2 0 AAA domain LRR_7 PF13504.1 KOO20885.1 - 0.15 12.3 3.6 45 4.8 0.1 5.4 5 0 0 5 5 5 0 Leucine rich repeat PPV_E1_C PF00519.12 KOO20885.1 - 0.16 10.5 0.0 3.5 6.1 0.0 2.3 2 0 0 2 2 2 0 Papillomavirus helicase AAA_16 PF13191.1 KOO20885.1 - 0.17 11.8 0.0 0.17 11.8 0.0 3.9 4 0 0 4 4 4 0 AAA ATPase domain Aminotran_3 PF00202.16 KOO20886.1 - 1.7e-62 211.2 0.0 2.5e-62 210.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-III APH PF01636.18 KOO20886.1 - 1.5e-12 47.8 3.0 1.5e-12 47.8 2.1 3.0 3 1 0 3 3 3 1 Phosphotransferase enzyme family KH_1 PF00013.24 KOO20887.1 - 1.9e-12 46.6 0.3 4.3e-12 45.5 0.2 1.6 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 KOO20887.1 - 8.3e-06 25.3 0.1 1.9e-05 24.1 0.1 1.6 1 0 0 1 1 1 1 KH domain Secretin_N PF03958.12 KOO20887.1 - 0.096 12.8 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial type II/III secretion system short domain Ribosomal_L18p PF00861.17 KOO20888.1 - 1.7e-40 137.9 0.0 2.6e-40 137.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal L18p/L5e family Ribosomal_L18_c PF14204.1 KOO20888.1 - 3.5e-31 107.6 5.6 7e-31 106.6 3.9 1.5 1 0 0 1 1 1 1 Ribosomal L18 C-terminal region GAS PF13851.1 KOO20889.1 - 2.3 7.3 29.3 0.042 13.0 8.5 3.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Syntaxin_2 PF14523.1 KOO20889.1 - 4.5 7.3 11.6 4.8 7.2 6.6 2.2 1 1 1 2 2 2 0 Syntaxin-like protein Gly-rich_Ago1 PF12764.2 KOO20889.1 - 5.8 7.6 13.1 0.18 12.4 3.8 2.4 2 0 0 2 2 2 0 Glycine-rich region of argonaut DUF1664 PF07889.7 KOO20889.1 - 6.6 6.5 10.1 6.1 6.6 0.2 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) WD40 PF00400.27 KOO20890.1 - 1.1e-23 82.1 13.3 3.1e-08 33.1 0.2 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat eIF2A PF08662.6 KOO20890.1 - 1.2e-05 25.1 1.7 0.052 13.2 0.9 4.4 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.7 KOO20890.1 - 0.0085 13.9 0.9 0.021 12.6 0.1 1.9 2 1 0 2 2 2 1 IKI3 family DPPIV_N PF00930.16 KOO20890.1 - 0.01 14.4 2.4 0.37 9.3 0.4 2.8 2 1 1 3 3 3 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region V_ATPase_I PF01496.14 KOO20891.1 - 5.1 4.8 22.6 0.79 7.5 2.4 3.3 1 1 3 4 4 4 0 V-type ATPase 116kDa subunit family CDC37_N PF03234.9 KOO20891.1 - 6.5 7.0 29.6 1.4 9.1 9.0 3.0 1 1 2 3 3 3 0 Cdc37 N terminal kinase binding IQ PF00612.22 KOO20892.1 - 0.018 14.6 6.5 0.9 9.3 0.2 3.0 2 0 0 2 2 2 0 IQ calmodulin-binding motif TLD PF07534.11 KOO20893.1 - 5.9e-18 65.1 0.2 1.3e-17 64.0 0.2 1.6 1 0 0 1 1 1 1 TLD AAA_16 PF13191.1 KOO20893.1 - 1.3e-05 25.2 0.1 3.6e-05 23.8 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.18 KOO20893.1 - 0.0024 17.8 0.0 0.0065 16.4 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase IIGP PF05049.8 KOO20893.1 - 0.0025 16.7 0.0 0.0044 15.8 0.0 1.3 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) FtsK_SpoIIIE PF01580.13 KOO20893.1 - 0.0032 16.9 0.0 0.0063 16.0 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family MobB PF03205.9 KOO20893.1 - 0.005 16.5 0.1 0.0093 15.6 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B DUF815 PF05673.8 KOO20893.1 - 0.017 14.0 0.0 0.027 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Miro PF08477.8 KOO20893.1 - 0.02 15.3 0.3 0.23 11.9 0.0 2.3 2 0 0 2 2 2 0 Miro-like protein ATP_bind_1 PF03029.12 KOO20893.1 - 0.031 13.8 0.2 1.5 8.3 0.0 2.6 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_24 PF13479.1 KOO20893.1 - 0.036 13.6 0.0 0.064 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 KOO20893.1 - 0.059 12.5 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 KOO20893.1 - 0.062 12.7 0.1 6.5 6.1 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain PPV_E1_C PF00519.12 KOO20893.1 - 0.064 11.8 0.0 0.092 11.3 0.0 1.1 1 0 0 1 1 1 0 Papillomavirus helicase AAA_10 PF12846.2 KOO20893.1 - 0.067 12.6 0.0 0.17 11.2 0.0 1.6 2 0 0 2 2 2 0 AAA-like domain RNA_helicase PF00910.17 KOO20893.1 - 0.11 12.7 0.0 0.29 11.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_23 PF13476.1 KOO20893.1 - 0.11 12.7 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.1 KOO20893.1 - 0.13 11.7 0.0 0.3 10.6 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.1 KOO20893.1 - 0.17 12.0 0.0 0.4 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 KOO20893.1 - 0.18 11.5 0.0 0.29 10.7 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase TrwB_AAD_bind PF10412.4 KOO20893.1 - 0.19 10.3 0.0 0.3 9.6 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Dynamin_N PF00350.18 KOO20895.1 - 1.3e-18 67.3 0.0 1.2e-16 61.0 0.0 2.2 1 1 0 1 1 1 1 Dynamin family EF-hand_4 PF12763.2 KOO20895.1 - 3.4e-15 55.6 0.0 9.9e-15 54.1 0.0 1.8 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand MMR_HSR1 PF01926.18 KOO20895.1 - 1.3e-10 41.2 0.0 3e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 KOO20895.1 - 6.2e-05 23.4 0.0 0.014 15.9 0.0 2.3 2 0 0 2 2 2 1 Miro-like protein GTP_EFTU PF00009.22 KOO20895.1 - 0.0049 16.3 0.0 0.055 12.8 0.0 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_28 PF13521.1 KOO20895.1 - 0.01 15.8 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Gtr1_RagA PF04670.7 KOO20895.1 - 0.016 14.3 0.0 0.34 10.0 0.0 2.1 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_22 PF13401.1 KOO20895.1 - 0.034 14.2 0.0 0.28 11.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 KOO20895.1 - 0.098 12.1 0.0 7.8 5.9 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AIG1 PF04548.11 KOO20895.1 - 0.16 11.0 0.0 0.3 10.1 0.0 1.4 1 0 0 1 1 1 0 AIG1 family zf-C3HC4_3 PF13920.1 KOO20896.1 - 9.3e-15 54.0 5.7 1.5e-14 53.3 4.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO20896.1 - 4.2e-08 33.0 10.1 6.6e-08 32.4 7.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO20896.1 - 6.8e-05 22.4 7.4 0.00011 21.7 5.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO20896.1 - 0.00041 20.1 9.2 0.00077 19.2 6.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 KOO20896.1 - 0.0007 19.2 8.5 0.0011 18.5 5.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-P11 PF03854.9 KOO20896.1 - 0.29 10.6 3.1 0.62 9.5 2.2 1.5 1 0 0 1 1 1 0 P-11 zinc finger Prok-RING_4 PF14447.1 KOO20896.1 - 1.4 8.4 5.6 3.9 7.0 3.9 1.7 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Lectin_legB PF00139.14 KOO20897.1 - 4.7e-10 39.2 0.0 9.5e-05 21.8 0.0 3.3 3 0 0 3 3 3 3 Legume lectin domain Phage_lysis PF03245.8 KOO20901.1 - 0.079 12.9 0.1 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein WD40 PF00400.27 KOO20903.1 - 5.4e-43 143.3 17.2 1e-08 34.7 0.1 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat Aa_trans PF01490.13 KOO20904.1 - 7.9e-19 67.4 19.1 1.3e-18 66.6 13.2 1.3 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Peptidase_M41 PF01434.13 KOO20905.1 - 1.1e-72 243.9 1.4 1.7e-72 243.3 1.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 KOO20905.1 - 5.6e-43 146.3 0.0 1.5e-42 144.8 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO20905.1 - 3.4e-06 27.1 1.4 0.0011 18.9 0.1 3.2 2 1 1 3 3 3 1 AAA ATPase domain TIP49 PF06068.8 KOO20905.1 - 5.8e-06 25.2 0.0 1.1e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus AAA_5 PF07728.9 KOO20905.1 - 1.2e-05 25.0 0.0 3.6e-05 23.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 KOO20905.1 - 2e-05 25.4 0.0 4.6e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KOO20905.1 - 4e-05 23.7 0.2 0.022 14.8 0.1 2.7 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.7 KOO20905.1 - 6.2e-05 22.1 0.0 0.00011 21.2 0.0 1.5 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 KOO20905.1 - 0.00013 21.6 0.2 0.00046 19.8 0.2 1.9 1 0 0 1 1 1 1 Part of AAA domain AAA_25 PF13481.1 KOO20905.1 - 0.0018 17.6 1.4 0.073 12.4 0.4 2.5 1 1 1 2 2 2 1 AAA domain IstB_IS21 PF01695.12 KOO20905.1 - 0.0022 17.4 0.1 0.0057 16.0 0.1 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 KOO20905.1 - 0.0053 16.6 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain PhoH PF02562.11 KOO20905.1 - 0.0064 15.7 0.3 0.31 10.2 0.1 2.3 2 0 0 2 2 2 1 PhoH-like protein AAA_28 PF13521.1 KOO20905.1 - 0.0079 16.1 0.1 0.019 14.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.9 KOO20905.1 - 0.018 14.9 0.0 0.055 13.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) NACHT PF05729.7 KOO20905.1 - 0.018 14.7 0.1 1.3 8.6 0.0 2.4 2 0 0 2 2 2 0 NACHT domain Mg_chelatase PF01078.16 KOO20905.1 - 0.02 14.0 0.3 0.083 12.0 0.1 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 KOO20905.1 - 0.022 14.6 0.0 0.062 13.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 KOO20905.1 - 0.032 14.5 0.0 0.075 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 KOO20905.1 - 0.049 13.1 0.1 0.61 9.5 0.1 2.4 1 1 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.7 KOO20905.1 - 0.073 12.1 0.5 0.13 11.3 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin SpoU_sub_bind PF08032.7 KOO20905.1 - 0.088 12.9 0.1 4.3 7.5 0.0 2.6 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding DUF2075 PF09848.4 KOO20905.1 - 0.13 11.2 0.0 0.21 10.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) KaiC PF06745.8 KOO20905.1 - 0.13 11.3 0.1 0.73 8.8 0.0 2.1 2 0 0 2 2 2 0 KaiC LRR_6 PF13516.1 KOO20906.1 - 1e-25 86.8 22.0 0.012 15.6 0.0 13.9 14 0 0 14 14 14 9 Leucine Rich repeat LRR_1 PF00560.28 KOO20906.1 - 3.4e-15 53.7 12.1 3.3 8.1 0.1 11.5 13 0 0 13 13 13 4 Leucine Rich Repeat LRR_4 PF12799.2 KOO20906.1 - 5.3e-12 45.0 15.1 1.5 8.5 0.0 9.8 8 1 0 9 9 9 5 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO20906.1 - 6.3e-07 28.5 20.9 4.9 7.7 0.2 11.3 13 0 0 13 13 13 2 Leucine rich repeat LRR_8 PF13855.1 KOO20906.1 - 0.0088 15.7 21.4 31 4.4 0.0 9.5 8 3 2 10 10 10 0 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO20906.1 - 0.042 14.0 0.1 58 3.9 0.0 4.5 5 1 1 6 6 6 0 RNA 2'-O ribose methyltransferase substrate binding MORN PF02493.15 KOO20906.1 - 0.13 12.0 4.1 2 8.2 0.1 3.1 3 0 0 3 3 3 0 MORN repeat Cellulase PF00150.13 KOO20907.1 - 4.6e-30 104.7 0.0 1.3e-24 86.9 0.0 2.1 2 0 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Cellulase-like PF12876.2 KOO20907.1 - 0.0067 16.8 0.0 0.016 15.6 0.0 1.6 1 0 0 1 1 1 1 Sugar-binding cellulase-like ketoacyl-synt PF00109.21 KOO20908.1 - 1.1e-53 182.2 8.6 1.7e-53 181.7 5.9 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 KOO20908.1 - 1.3e-30 105.6 0.7 2.8e-30 104.6 0.5 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 KOO20908.1 - 0.0017 17.4 1.0 0.0029 16.6 0.7 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain FKBP_C PF00254.23 KOO20909.1 - 4.9e-18 64.9 0.0 6.9e-18 64.4 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.13 KOO20909.1 - 2.9e-09 37.0 0.0 9e-09 35.4 0.0 1.7 2 0 0 2 2 2 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase ShK PF01549.19 KOO20910.1 - 4.8e-09 36.4 14.9 4.3e-06 26.9 1.6 3.1 3 0 0 3 3 3 2 ShK domain-like WW PF00397.21 KOO20910.1 - 2e-08 33.9 2.2 5.3e-08 32.5 1.5 1.8 1 0 0 1 1 1 1 WW domain 2OG-FeII_Oxy PF03171.15 KOO20910.1 - 4.9e-06 26.7 0.0 7.9e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.1 KOO20910.1 - 2.8e-05 24.5 0.0 7.7e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily HALZ PF02183.13 KOO20911.1 - 0.047 13.4 1.1 0.09 12.5 0.2 1.9 2 0 0 2 2 2 0 Homeobox associated leucine zipper ERM PF00769.14 KOO20911.1 - 8.6 5.8 14.7 2.6 7.5 3.3 2.3 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Dynein_heavy PF03028.10 KOO20912.1 - 1.6e-239 796.6 0.0 2.6e-239 796.0 0.0 1.3 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DHC_N1 PF08385.7 KOO20912.1 - 3.8e-170 567.1 0.3 3.8e-170 567.1 0.2 2.0 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.8 KOO20912.1 - 3.5e-113 378.1 2.2 3.5e-113 378.1 1.5 5.0 5 1 1 6 6 6 3 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.2 KOO20912.1 - 4.7e-107 356.9 0.0 1.2e-106 355.6 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_6 PF12774.2 KOO20912.1 - 2.8e-104 347.6 0.1 2e-103 344.9 0.0 2.4 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_7 PF12775.2 KOO20912.1 - 2.5e-84 282.5 0.0 5.1e-84 281.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 MT PF12777.2 KOO20912.1 - 2e-79 266.8 13.0 4.2e-79 265.8 9.0 1.6 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_9 PF12781.2 KOO20912.1 - 9e-68 227.5 0.0 2.5e-67 226.0 0.0 1.8 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_5 PF07728.9 KOO20912.1 - 3.3e-12 46.3 0.0 0.0043 16.7 0.0 5.3 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 KOO20912.1 - 0.0026 17.9 1.0 12 5.9 0.0 4.5 4 0 0 4 4 4 0 AAA domain AAA PF00004.24 KOO20912.1 - 0.0066 16.6 0.6 5.5 7.2 0.0 3.9 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 KOO20912.1 - 0.26 11.0 4.6 23 4.8 0.0 3.8 3 0 0 3 3 3 0 Part of AAA domain MutS_III PF05192.13 KOO20912.1 - 8.7 6.0 5.7 1.5e+02 2.0 1.1 4.6 4 1 1 5 5 5 0 MutS domain III HATPase_c_3 PF13589.1 KOO20913.1 - 0.0045 16.6 0.1 0.0091 15.6 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Nucleoporin_C PF03177.9 KOO20913.1 - 0.061 11.8 0.0 0.096 11.1 0.0 1.2 1 0 0 1 1 1 0 Non-repetitive/WGA-negative nucleoporin C-terminal FimP PF09766.4 KOO20914.1 - 8.7e-10 38.1 0.0 2.2e-08 33.5 0.0 2.0 2 0 0 2 2 2 1 Fms-interacting protein IncA PF04156.9 KOO20914.1 - 0.039 13.5 3.5 0.11 12.0 2.4 1.7 1 1 0 1 1 1 0 IncA protein Filament PF00038.16 KOO20914.1 - 0.078 12.4 1.4 5.4 6.3 0.2 2.1 2 0 0 2 2 2 0 Intermediate filament protein Bap31 PF05529.7 KOO20914.1 - 0.23 10.9 2.2 0.15 11.5 0.2 1.6 2 0 0 2 2 2 0 B-cell receptor-associated protein 31-like DUF3584 PF12128.3 KOO20914.1 - 0.68 7.1 7.5 0.24 8.7 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Polyketide_cyc2 PF10604.4 KOO20915.1 - 1.6e-11 44.5 0.0 1.9e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.15 KOO20915.1 - 7.6e-09 35.6 0.0 1.1e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport COXG PF06240.8 KOO20915.1 - 7.2e-05 22.4 0.0 0.0001 21.9 0.0 1.2 1 0 0 1 1 1 1 Carbon monoxide dehydrogenase subunit G (CoxG) DUF2917 PF11142.3 KOO20916.1 - 0.028 13.5 0.0 0.43 9.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2917) SNARE_assoc PF09335.6 KOO20916.1 - 0.058 13.6 1.7 0.09 12.9 1.2 1.3 1 0 0 1 1 1 0 SNARE associated Golgi protein Methyltransf_21 PF05050.7 KOO20918.1 - 3.9e-13 49.6 0.0 5.2e-13 49.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_18 PF12847.2 KOO20918.1 - 0.00053 20.5 0.0 0.001 19.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO20918.1 - 0.026 14.2 0.0 0.037 13.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain BCDHK_Adom3 PF10436.4 KOO20919.1 - 4.1e-20 71.9 0.1 6.1e-20 71.3 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 KOO20919.1 - 8.4e-18 64.1 0.0 1.6e-17 63.2 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 KOO20919.1 - 0.0015 18.2 0.0 0.0028 17.2 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TPR_11 PF13414.1 KOO20920.1 - 9.4e-32 108.4 84.2 8.2e-06 25.3 2.8 16.0 12 3 3 15 15 15 10 TPR repeat TPR_16 PF13432.1 KOO20920.1 - 2.1e-31 107.8 113.8 6.1e-05 23.5 1.5 19.0 13 4 7 20 20 20 9 Tetratricopeptide repeat TPR_19 PF14559.1 KOO20920.1 - 2.6e-31 107.7 110.1 1.7e-05 25.0 1.8 19.3 12 5 10 23 23 22 12 Tetratricopeptide repeat TPR_14 PF13428.1 KOO20920.1 - 1.6e-26 90.3 110.2 0.00061 20.1 0.7 24.6 16 8 10 26 26 26 10 Tetratricopeptide repeat TPR_1 PF00515.23 KOO20920.1 - 1.9e-22 77.8 55.1 0.00055 19.4 0.1 16.2 18 0 0 18 18 18 9 Tetratricopeptide repeat TPR_2 PF07719.12 KOO20920.1 - 1.5e-20 71.3 87.5 0.00061 19.5 0.0 21.3 23 0 0 23 23 22 8 Tetratricopeptide repeat TPR_8 PF13181.1 KOO20920.1 - 1.5e-18 65.0 25.2 0.69 9.8 0.2 14.2 13 0 0 13 13 12 6 Tetratricopeptide repeat TPR_12 PF13424.1 KOO20920.1 - 1.6e-13 50.3 92.1 0.033 14.1 2.7 16.2 11 4 6 17 17 17 8 Tetratricopeptide repeat TPR_17 PF13431.1 KOO20920.1 - 8e-09 35.0 27.7 0.024 14.7 0.1 11.5 11 1 1 12 12 11 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO20920.1 - 6.3e-05 22.4 58.3 0.59 10.0 0.0 16.7 18 1 1 19 19 18 3 Tetratricopeptide repeat TPR_15 PF13429.1 KOO20920.1 - 8.8e-05 21.6 2.0 8.8e-05 21.6 1.4 9.1 7 3 2 9 9 9 2 Tetratricopeptide repeat TPR_6 PF13174.1 KOO20920.1 - 0.00013 22.1 74.2 0.14 12.6 0.1 18.6 22 0 0 22 22 19 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO20920.1 - 0.0042 16.8 54.5 0.014 15.2 0.6 10.1 8 2 2 10 10 10 4 Tetratricopeptide repeat TPR_20 PF14561.1 KOO20920.1 - 0.025 14.6 0.7 0.025 14.6 0.5 12.7 11 4 6 17 17 16 0 Tetratricopeptide repeat ChAPs PF09295.5 KOO20920.1 - 0.093 11.4 11.5 0.13 11.0 0.1 4.3 4 1 1 5 5 5 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_4 PF07721.9 KOO20920.1 - 0.12 12.8 0.0 0.12 12.8 0.0 12.6 15 1 0 15 15 10 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO20920.1 - 0.33 10.8 14.1 0.067 13.0 0.2 5.4 6 0 0 6 6 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_21 PF09976.4 KOO20920.1 - 0.74 9.7 77.7 0.0096 15.8 5.4 10.0 8 3 3 11 11 11 0 Tetratricopeptide repeat PPR_1 PF12854.2 KOO20920.1 - 0.85 9.1 2.5 19 4.8 0.1 3.3 3 0 0 3 3 3 0 PPR repeat PPR_2 PF13041.1 KOO20921.1 - 2.5e-05 24.1 0.0 0.064 13.2 0.0 2.6 1 1 1 2 2 2 2 PPR repeat family PPR_3 PF13812.1 KOO20921.1 - 0.0012 18.9 0.5 0.43 10.9 0.0 2.9 3 0 0 3 3 3 2 Pentatricopeptide repeat domain TF_Zn_Ribbon PF08271.7 KOO20923.1 - 1.5e-05 24.2 2.4 3e-05 23.2 1.6 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding ASL_C PF08328.6 KOO20923.1 - 0.0051 16.6 0.1 0.016 15.0 0.0 1.9 2 1 0 2 2 2 1 Adenylosuccinate lyase C-terminal HTH_24 PF13412.1 KOO20923.1 - 0.041 13.2 0.0 0.11 11.9 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding SVWC PF15430.1 KOO20923.1 - 0.068 13.6 1.4 0.15 12.5 0.9 1.6 1 0 0 1 1 1 0 Single domain von Willebrand factor type C TetR_N PF00440.18 KOO20923.1 - 0.083 12.5 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family HTH_10 PF04967.7 KOO20923.1 - 0.1 12.2 0.1 0.3 10.7 0.0 1.8 1 0 0 1 1 1 0 HTH DNA binding domain HTH_IclR PF09339.5 KOO20923.1 - 0.18 11.4 2.0 0.39 10.3 0.1 2.5 2 1 1 3 3 3 0 IclR helix-turn-helix domain FOLN PF09289.5 KOO20923.1 - 0.27 11.1 3.5 0.58 10.0 0.2 2.5 2 0 0 2 2 2 0 Follistatin/Osteonectin-like EGF domain LRR_6 PF13516.1 KOO20924.1 - 7.6e-14 50.1 7.7 8.4e-05 22.2 0.3 5.1 5 0 0 5 5 5 4 Leucine Rich repeat Skp1 PF01466.14 KOO20924.1 - 0.00033 20.6 0.1 0.0012 18.8 0.0 1.9 2 0 0 2 2 2 1 Skp1 family, dimerisation domain LRR_4 PF12799.2 KOO20924.1 - 0.0017 17.9 0.2 1.1 9.0 0.1 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO20924.1 - 0.0046 16.9 0.8 48 4.8 0.1 3.9 3 0 0 3 3 3 0 Leucine rich repeat LRR_1 PF00560.28 KOO20924.1 - 0.0066 16.3 0.8 8.5 6.8 0.1 4.0 3 1 0 3 3 3 1 Leucine Rich Repeat LRR_8 PF13855.1 KOO20924.1 - 0.064 13.0 2.1 8.3 6.2 0.0 2.9 2 1 0 2 2 2 0 Leucine rich repeat DUF4611 PF15387.1 KOO20925.1 - 0.075 13.1 0.1 0.15 12.1 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4611) VDE PF07137.6 KOO20926.1 - 2.8e-10 40.3 0.0 4e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 Violaxanthin de-epoxidase (VDE) Septin PF00735.13 KOO20927.1 - 1.2e-60 204.9 0.0 6.3e-52 176.3 0.0 2.1 2 0 0 2 2 2 2 Septin AAA_16 PF13191.1 KOO20927.1 - 1.2e-06 28.6 2.4 2.4e-06 27.6 1.7 1.5 1 0 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.22 KOO20927.1 - 0.00013 21.5 0.1 3 7.2 0.0 3.3 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 KOO20927.1 - 0.0012 18.9 0.6 0.0033 17.5 0.1 1.9 2 1 0 2 2 1 1 AAA domain Dynamin_N PF00350.18 KOO20927.1 - 0.0018 18.0 3.6 0.017 14.9 0.8 2.8 2 1 0 2 2 2 1 Dynamin family ABC_tran PF00005.22 KOO20927.1 - 0.0031 17.7 0.1 0.0076 16.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter T2SE PF00437.15 KOO20927.1 - 0.0033 16.3 0.0 0.0064 15.4 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.13 KOO20927.1 - 0.004 16.6 0.5 0.13 11.7 0.1 2.5 2 1 0 2 2 2 1 FtsK/SpoIIIE family NACHT PF05729.7 KOO20927.1 - 0.0046 16.6 0.0 0.01 15.5 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Arch_ATPase PF01637.13 KOO20927.1 - 0.005 16.5 1.0 0.0056 16.4 0.1 1.5 2 0 0 2 2 1 1 Archaeal ATPase MobB PF03205.9 KOO20927.1 - 0.0062 16.2 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B Miro PF08477.8 KOO20927.1 - 0.0083 16.6 0.0 0.028 14.9 0.0 2.0 2 0 0 2 2 1 1 Miro-like protein NB-ARC PF00931.17 KOO20927.1 - 0.0083 15.0 0.0 0.022 13.6 0.0 1.7 2 0 0 2 2 2 1 NB-ARC domain AAA_5 PF07728.9 KOO20927.1 - 0.016 14.9 0.1 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Pox_A32 PF04665.7 KOO20927.1 - 0.017 14.4 0.0 0.032 13.5 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein Ras PF00071.17 KOO20927.1 - 0.032 13.6 0.4 0.18 11.2 0.0 2.4 2 1 1 3 3 3 0 Ras family AAA_24 PF13479.1 KOO20927.1 - 0.034 13.7 0.0 0.22 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.18 KOO20927.1 - 0.047 13.6 0.0 6.6 6.7 0.0 2.6 2 1 0 2 2 2 0 50S ribosome-binding GTPase ATP_bind_1 PF03029.12 KOO20927.1 - 0.051 13.1 0.0 2.2 7.7 0.0 2.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Mg_chelatase PF01078.16 KOO20927.1 - 0.07 12.2 0.2 0.66 9.1 0.5 2.4 2 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI KAP_NTPase PF07693.9 KOO20927.1 - 0.087 11.7 0.1 0.41 9.6 0.0 1.6 1 1 0 2 2 2 0 KAP family P-loop domain PduV-EutP PF10662.4 KOO20927.1 - 0.16 11.4 1.5 6.2 6.2 0.1 3.2 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Seryl_tRNA_N PF02403.17 KOO20927.1 - 1.5 8.8 8.5 1.4 8.9 4.5 2.0 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Histone_HNS PF00816.16 KOO20927.1 - 6.1 7.4 14.3 12 6.5 4.4 2.9 2 1 1 3 3 2 0 H-NS histone family RGS PF00615.14 KOO20928.1 - 4.2e-23 81.6 0.2 3.3e-09 36.8 0.0 3.1 3 0 0 3 3 3 3 Regulator of G protein signaling domain CLTH PF10607.4 KOO20929.1 - 3.5e-11 42.9 0.0 2.7e-10 40.0 0.0 2.2 1 1 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LRR_4 PF12799.2 KOO20931.1 - 3.6e-17 61.5 6.7 1.2e-07 31.1 0.0 3.2 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO20931.1 - 1.3e-15 56.9 21.7 1.5e-08 34.2 3.9 3.0 3 1 2 5 5 5 3 Leucine rich repeat LRR_1 PF00560.28 KOO20931.1 - 1.3e-07 30.6 10.3 0.71 10.1 0.3 4.9 4 0 0 4 4 4 4 Leucine Rich Repeat LRR_9 PF14580.1 KOO20931.1 - 1.8e-07 30.9 0.9 6.1e-06 25.9 0.1 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_7 PF13504.1 KOO20931.1 - 1.5e-06 27.4 11.0 3.8 8.1 0.2 5.4 5 0 0 5 5 5 4 Leucine rich repeat LRR_6 PF13516.1 KOO20931.1 - 0.00089 19.0 11.2 5.6 7.3 0.5 5.1 3 2 2 5 5 5 2 Leucine Rich repeat LRR_2 PF07723.8 KOO20931.1 - 0.28 11.7 1.4 20 5.8 0.0 3.2 3 1 1 4 4 4 0 Leucine Rich Repeat Ion_trans PF00520.26 KOO20933.1 - 1.5e-25 89.6 11.2 2.2e-25 89.0 7.7 1.3 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.7 KOO20933.1 - 0.17 10.2 15.4 0.17 10.3 7.4 2.6 2 1 0 2 2 2 0 Polycystin cation channel zf-RING_2 PF13639.1 KOO20934.1 - 2e-12 46.7 3.9 3.3e-12 46.0 2.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KOO20934.1 - 8.3e-10 38.6 1.1 1.3e-09 37.9 0.8 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 KOO20934.1 - 6.8e-06 26.0 2.2 0.0002 21.3 1.5 2.3 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO20934.1 - 0.00013 21.4 3.1 0.0019 17.7 2.2 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO20934.1 - 0.0039 16.8 4.3 0.17 11.5 0.5 2.2 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.2 KOO20934.1 - 0.0072 16.3 2.3 0.074 13.1 1.6 2.1 1 1 0 1 1 1 1 RING-variant domain zf-Apc11 PF12861.2 KOO20934.1 - 0.0094 15.7 0.1 0.0094 15.7 0.1 1.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.1 KOO20934.1 - 0.027 14.2 4.6 0.53 10.0 3.1 2.2 1 1 1 2 2 2 0 zinc-RING finger domain zf-P11 PF03854.9 KOO20934.1 - 0.032 13.6 2.4 0.12 11.9 0.1 2.1 2 0 0 2 2 2 0 P-11 zinc finger Rad50_zn_hook PF04423.9 KOO20934.1 - 0.14 11.6 0.5 4.5 6.8 0.0 2.6 2 0 0 2 2 2 0 Rad50 zinc hook motif FANCL_C PF11793.3 KOO20934.1 - 1 9.4 4.1 5.4 7.0 2.9 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain GAGA PF09237.6 KOO20934.1 - 3.3 7.3 4.6 11 5.6 0.7 2.7 2 0 0 2 2 2 0 GAGA factor Ank_2 PF12796.2 KOO20935.1 - 4.5e-29 100.6 0.2 8.9e-15 54.8 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO20935.1 - 3.1e-18 65.7 2.2 7.2e-10 39.1 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO20935.1 - 5.3e-16 57.5 0.9 2.5e-07 30.1 0.1 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 KOO20935.1 - 1.7e-14 53.5 0.8 2.7e-09 36.9 0.3 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO20935.1 - 2.2e-08 33.5 0.0 0.0086 16.2 0.0 3.2 2 0 0 2 2 2 2 Ankyrin repeat DUF4231 PF14015.1 KOO20935.1 - 2.1e-05 24.4 0.0 0.0014 18.5 0.0 3.0 2 0 0 2 2 2 1 Protein of unknown function (DUF4231) Aa_trans PF01490.13 KOO20935.1 - 8e-05 21.2 0.1 0.00011 20.8 0.1 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein EF-hand_5 PF13202.1 KOO20935.1 - 0.013 14.7 0.0 0.036 13.4 0.0 1.7 1 0 0 1 1 1 0 EF hand Methyltrans_SAM PF10672.4 KOO20935.1 - 0.019 13.8 0.0 0.039 12.8 0.0 1.4 1 0 0 1 1 1 0 S-adenosylmethionine-dependent methyltransferase EF-hand_1 PF00036.27 KOO20935.1 - 0.097 12.0 0.0 0.26 10.6 0.0 1.8 1 0 0 1 1 1 0 EF hand Ion_trans_2 PF07885.11 KOO20936.1 - 1.4e-18 66.3 20.2 2.1e-09 36.9 0.6 4.1 4 1 0 4 4 4 3 Ion channel cNMP_binding PF00027.24 KOO20936.1 - 6.8e-14 51.4 0.0 3.2e-10 39.6 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Ion_trans PF00520.26 KOO20936.1 - 1.8e-10 40.4 14.7 2.6e-07 30.0 0.2 3.5 3 0 0 3 3 3 2 Ion transport protein Med26 PF08711.6 KOO20936.1 - 0.15 11.6 0.2 0.62 9.6 0.0 2.1 2 0 0 2 2 2 0 TFIIS helical bundle-like domain Metallophos PF00149.23 KOO20937.1 - 7.6e-19 67.9 0.0 1.3e-18 67.0 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.1 KOO20937.1 - 3.1e-12 46.3 0.3 1.3e-11 44.3 0.1 2.1 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C Metallophos_2 PF12850.2 KOO20937.1 - 3e-06 27.1 0.0 5.1e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PGA_cap PF09587.5 KOO20937.1 - 0.0075 15.6 0.0 0.012 14.9 0.0 1.4 1 0 0 1 1 1 1 Bacterial capsule synthesis protein PGA_cap Pkinase PF00069.20 KOO20938.1 - 7.6e-42 143.2 0.1 7.7e-41 139.9 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain MFS_1 PF07690.11 KOO20938.1 - 4.5e-25 88.1 25.2 4.5e-25 88.1 17.5 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase_Tyr PF07714.12 KOO20938.1 - 8.5e-16 57.7 0.0 1.4e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Sugar_tr PF00083.19 KOO20938.1 - 1.3e-11 43.7 4.8 1.3e-11 43.7 3.4 3.0 2 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.15 KOO20938.1 - 1.7e-09 36.2 1.4 1.8e-08 32.9 1.0 2.3 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Kinase-like PF14531.1 KOO20938.1 - 0.014 14.3 0.0 0.027 13.4 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Pox_ser-thr_kin PF05445.6 KOO20938.1 - 0.51 9.0 0.0 0.8 8.4 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pterin_bind PF00809.17 KOO20939.1 - 4e-56 189.7 0.0 7.2e-56 188.8 0.0 1.5 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.15 KOO20939.1 - 1.6e-35 121.6 0.0 2.6e-35 120.9 0.0 1.4 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) FolB PF02152.13 KOO20939.1 - 4.1e-22 78.4 0.0 6.5e-22 77.8 0.0 1.3 1 0 0 1 1 1 1 Dihydroneopterin aldolase Coat_F PF07875.7 KOO20941.1 - 0.032 14.3 0.3 0.91 9.6 0.1 2.9 2 0 0 2 2 2 0 Coat F domain Peptidase_S64 PF08192.6 KOO20941.1 - 4 5.6 7.1 5.6 5.1 4.9 1.4 1 0 0 1 1 1 0 Peptidase family S64 ACCA PF03255.9 KOO20941.1 - 7.4 6.1 11.3 1.5 8.3 0.1 3.5 3 0 0 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Glyco_hydro_65m PF03632.10 KOO20942.1 - 1.4e-77 260.9 0.1 2.3e-76 256.8 0.1 2.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 65 central catalytic domain DUF2152 PF10222.4 KOO20942.1 - 7.5e-06 24.4 0.0 0.053 11.7 0.0 2.6 2 1 0 2 2 2 2 Uncharacterized conserved protein (DUF2152) Ank_2 PF12796.2 KOO20943.1 - 1.1e-35 121.8 9.3 6.4e-16 58.4 0.3 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) WD40 PF00400.27 KOO20943.1 - 2.2e-31 106.5 1.8 7e-06 25.7 0.0 6.6 6 1 1 7 7 7 5 WD domain, G-beta repeat Ank PF00023.25 KOO20943.1 - 2.6e-27 93.2 11.9 1.2e-06 28.0 0.0 7.4 7 0 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.1 KOO20943.1 - 2.6e-25 87.8 12.6 3.7e-08 33.3 0.0 5.3 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO20943.1 - 2.1e-22 79.0 4.5 1.9e-07 31.3 0.0 4.5 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO20943.1 - 1.7e-17 61.7 8.3 0.0032 17.5 0.0 6.6 6 0 0 6 6 6 5 Ankyrin repeat LRR_6 PF13516.1 KOO20943.1 - 5.1e-08 32.2 1.6 7.4e-05 22.4 0.0 4.4 5 0 0 5 5 4 1 Leucine Rich repeat LRR_4 PF12799.2 KOO20943.1 - 0.0051 16.4 0.1 2.6 7.7 0.0 2.9 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) DUF1110 PF06533.7 KOO20943.1 - 0.025 14.4 1.7 3.8 7.2 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1110) LRR_1 PF00560.28 KOO20943.1 - 0.13 12.3 0.9 18 5.8 0.0 3.6 3 0 0 3 3 3 0 Leucine Rich Repeat F-box PF00646.28 KOO20943.1 - 0.16 11.6 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 F-box domain Kinesin PF00225.18 KOO20944.1 - 5.1e-76 255.5 0.0 1e-75 254.5 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain Calpain_III PF01067.17 KOO20944.1 - 3.1e-11 43.1 0.0 9.1e-10 38.3 0.0 3.2 4 1 0 4 4 4 1 Calpain large subunit, domain III IncA PF04156.9 KOO20944.1 - 3.8e-06 26.6 1.0 3.8e-06 26.6 0.7 4.2 2 1 0 2 2 2 1 IncA protein Arm PF00514.18 KOO20944.1 - 0.029 14.2 0.1 5 7.0 0.0 3.5 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat AAA_22 PF13401.1 KOO20944.1 - 0.031 14.4 0.0 0.17 12.0 0.0 2.3 1 0 0 1 1 1 0 AAA domain Sec20 PF03908.8 KOO20944.1 - 0.073 12.7 1.9 0.16 11.6 0.3 2.5 2 0 0 2 2 2 0 Sec20 MFS_1 PF07690.11 KOO20945.1 - 0.0094 14.6 3.0 0.014 14.1 2.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily EF-hand_7 PF13499.1 KOO20946.1 - 1.4e-13 50.7 0.1 2.3e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO20946.1 - 6.9e-13 46.8 0.1 2.4e-05 23.3 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO20946.1 - 1.1e-11 43.6 0.3 1.9e-05 24.1 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO20946.1 - 1.8e-09 36.5 0.1 0.0006 19.0 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO20946.1 - 1.2e-06 27.9 0.9 0.00064 19.2 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.2 KOO20946.1 - 0.084 12.6 0.1 0.22 11.2 0.1 1.7 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO20946.1 - 0.1 12.2 0.2 9.8 5.9 0.1 2.3 2 0 0 2 2 2 0 EF hand Frigida PF07899.6 KOO20948.1 - 5.5e-05 22.0 0.0 0.00025 19.9 0.0 1.9 1 1 1 2 2 2 2 Frigida-like protein Pkinase PF00069.20 KOO20949.1 - 4.5e-24 84.9 0.0 1e-23 83.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain U-box PF04564.10 KOO20949.1 - 1.5e-20 72.9 0.0 4.2e-19 68.2 0.0 2.6 2 0 0 2 2 2 1 U-box domain Pkinase_Tyr PF07714.12 KOO20949.1 - 3.7e-14 52.4 0.0 7.6e-14 51.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DnaJ PF00226.26 KOO20949.1 - 0.00013 21.6 0.0 0.00044 19.9 0.0 1.9 1 0 0 1 1 1 1 DnaJ domain zf-Nse PF11789.3 KOO20949.1 - 0.15 11.5 0.0 0.38 10.2 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prefoldin_2 PF01920.15 KOO20951.1 - 1.1e-20 73.3 0.2 1.3e-20 73.0 0.1 1.1 1 0 0 1 1 1 1 Prefoldin subunit Tup_N PF08581.5 KOO20951.1 - 0.0086 16.2 0.9 0.044 13.9 0.1 2.0 2 0 0 2 2 2 1 Tup N-terminal FTA4 PF13093.1 KOO20951.1 - 0.051 13.0 0.2 0.061 12.7 0.1 1.1 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Prefoldin PF02996.12 KOO20951.1 - 0.061 12.9 4.2 0.074 12.6 1.3 1.9 1 1 0 2 2 2 0 Prefoldin subunit TBPIP PF07106.8 KOO20951.1 - 0.077 12.5 1.0 0.56 9.7 0.1 2.0 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) AATF-Che1 PF13339.1 KOO20951.1 - 0.11 12.6 0.5 0.6 10.2 0.1 1.9 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor WXG100 PF06013.7 KOO20951.1 - 0.12 12.3 0.2 18 5.4 0.0 2.1 2 0 0 2 2 2 0 Proteins of 100 residues with WXG IncA PF04156.9 KOO20951.1 - 0.99 8.9 6.5 8.2 5.9 1.4 1.9 1 1 0 1 1 1 0 IncA protein TPR_12 PF13424.1 KOO20953.1 - 1e-76 252.8 52.8 1.2e-17 63.5 0.5 5.5 2 1 4 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.1 KOO20953.1 - 9.9e-66 215.9 46.1 3.8e-12 45.6 0.1 8.7 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.12 KOO20953.1 - 9.2e-16 56.4 28.6 0.0056 16.5 0.1 8.5 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_1 PF00515.23 KOO20953.1 - 4.1e-15 54.6 19.3 0.00071 19.0 0.1 8.1 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_7 PF13176.1 KOO20953.1 - 6.7e-15 53.6 36.1 0.001 18.6 0.1 8.4 9 0 0 9 9 8 6 Tetratricopeptide repeat TPR_11 PF13414.1 KOO20953.1 - 1.3e-13 50.3 24.3 5.2e-05 22.8 0.1 5.9 4 1 2 6 6 6 4 TPR repeat TPR_4 PF07721.9 KOO20953.1 - 1.5e-12 46.6 28.5 0.064 13.7 0.4 9.1 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_8 PF13181.1 KOO20953.1 - 3.1e-12 45.3 16.9 0.0064 16.1 0.2 7.9 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO20953.1 - 1.7e-11 43.3 7.2 0.39 11.0 0.0 7.8 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOO20953.1 - 1.4e-09 37.7 46.8 0.087 13.5 0.1 10.0 8 2 2 10 10 9 5 Tetratricopeptide repeat TPR_16 PF13432.1 KOO20953.1 - 1.9e-08 34.7 49.8 0.00028 21.4 1.5 7.3 5 3 1 7 7 6 4 Tetratricopeptide repeat LRR_6 PF13516.1 KOO20953.1 - 1.1e-07 31.1 1.9 0.03 14.3 0.0 4.0 4 0 0 4 4 4 2 Leucine Rich repeat TPR_19 PF14559.1 KOO20953.1 - 2.1e-05 24.7 28.8 0.021 15.1 0.2 5.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOO20953.1 - 0.046 14.1 22.4 6.3 7.4 0.0 8.2 8 1 1 9 9 9 0 Tetratricopeptide repeat PPR PF01535.15 KOO20953.1 - 0.41 10.7 2.6 1.3 9.1 0.0 3.2 4 0 0 4 4 4 0 PPR repeat Abhydrolase_6 PF12697.2 KOO20954.1 - 1.4e-22 80.6 1.4 1.8e-22 80.3 1.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO20954.1 - 5.8e-06 26.1 0.0 1.7e-05 24.6 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO20954.1 - 3.9e-05 23.3 0.0 0.0032 17.0 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.5 KOO20954.1 - 0.025 14.4 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein Ser_hydrolase PF06821.8 KOO20954.1 - 0.037 13.6 0.0 1.3 8.6 0.0 2.3 1 1 1 2 2 2 0 Serine hydrolase DLH PF01738.13 KOO20954.1 - 0.091 12.0 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family Synaptobrevin PF00957.16 KOO20955.1 - 5.4e-14 51.5 0.6 8.5e-14 50.9 0.4 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.1 KOO20955.1 - 5.8e-07 28.9 0.0 1e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Viral_P18 PF04521.8 KOO20955.1 - 0.1 12.0 1.2 0.17 11.3 0.8 1.3 1 0 0 1 1 1 0 ssRNA positive strand viral 18kD cysteine rich protein Ribosomal_S6 PF01250.12 KOO20956.1 - 1.2e-14 53.8 0.0 1.7e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S6 IBN_N PF03810.14 KOO20957.1 - 7.7e-08 32.1 0.3 7.7e-08 32.1 0.2 2.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain CRM1_C PF08767.6 KOO20957.1 - 0.011 14.6 0.4 0.032 13.1 0.0 1.9 2 0 0 2 2 2 0 CRM1 C terminal Ank_2 PF12796.2 KOO20959.1 - 2e-18 66.5 4.6 1.5e-12 47.6 0.0 2.7 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO20959.1 - 1.4e-17 62.5 3.7 7.6e-08 31.7 0.0 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 KOO20959.1 - 7.8e-14 51.3 3.7 4.9e-06 26.6 0.1 4.6 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO20959.1 - 2.9e-13 48.6 2.2 0.0011 19.0 0.0 4.2 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.1 KOO20959.1 - 5.6e-11 42.6 0.2 2.1e-06 28.0 0.0 3.5 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Cas_CT1975 PF09344.5 KOO20959.1 - 0.011 15.0 8.7 0.086 12.1 5.3 2.1 1 1 1 2 2 2 0 CT1975-like protein Lumazine_bd PF12870.2 KOO20959.1 - 0.87 9.6 5.0 1.3 9.0 2.3 2.0 2 1 0 2 2 2 0 Lumazine-binding domain AAA_11 PF13086.1 KOO20960.1 - 1e-65 221.6 0.0 1.9e-64 217.4 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_12 PF13087.1 KOO20960.1 - 1.5e-60 204.0 0.0 2.2e-60 203.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOO20960.1 - 1e-14 53.9 0.0 7.1e-12 44.9 0.0 3.1 2 1 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 KOO20960.1 - 5.9e-09 35.7 0.0 1.1e-06 28.4 0.0 3.1 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 KOO20960.1 - 7.1e-07 28.9 0.2 0.0037 16.8 0.0 3.2 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.16 KOO20960.1 - 0.0011 18.3 0.0 1.1 8.5 0.0 2.4 2 1 0 2 2 2 2 UvrD/REP helicase N-terminal domain DEAD PF00270.24 KOO20960.1 - 0.0011 18.4 0.0 0.0037 16.7 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase Mg_chelatase PF01078.16 KOO20960.1 - 0.09 11.9 0.1 0.18 10.9 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_22 PF13401.1 KOO20960.1 - 0.093 12.8 0.1 0.42 10.7 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.1 KOO20960.1 - 0.17 11.4 0.1 0.39 10.2 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF2075 PF09848.4 KOO20960.1 - 0.2 10.5 0.1 1.1 8.1 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) 6PF2K PF01591.13 KOO20961.1 - 1.8e-30 105.6 0.1 1.8e-21 76.2 0.0 2.1 1 1 1 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 KOO20961.1 - 2.4e-17 63.4 0.0 4.4e-17 62.6 0.0 1.5 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Cullin PF00888.17 KOO20962.1 - 4.7e-45 154.2 0.0 8.5e-45 153.3 0.0 1.3 1 0 0 1 1 1 1 Cullin family APC2 PF08672.6 KOO20962.1 - 2.4e-19 69.3 0.0 4.6e-19 68.4 0.0 1.5 1 0 0 1 1 1 1 Anaphase promoting complex (APC) subunit 2 FeoC PF09012.5 KOO20962.1 - 0.0064 16.1 0.0 0.028 14.1 0.0 2.1 2 0 0 2 2 2 1 FeoC like transcriptional regulator MarR_2 PF12802.2 KOO20962.1 - 0.044 13.4 0.1 0.35 10.5 0.0 2.5 2 0 0 2 2 2 0 MarR family GRIM-19 PF06212.7 KOO20963.1 - 4.9e-28 97.4 0.6 3.7e-25 88.1 0.4 2.1 1 1 0 1 1 1 1 GRIM-19 protein DUF2555 PF10742.4 KOO20963.1 - 0.0022 17.5 0.1 0.0037 16.8 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2555) Ribosomal_L13 PF00572.13 KOO20964.1 - 3.3e-49 166.1 0.0 4.1e-49 165.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 Gly-zipper_Omp PF13488.1 KOO20965.1 - 0.058 13.0 10.0 0.086 12.4 0.4 2.6 2 0 0 2 2 2 0 Glycine zipper ERM PF00769.14 KOO20965.1 - 0.1 12.1 7.6 0.55 9.7 2.2 2.3 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Gly-zipper_YMGG PF13441.1 KOO20965.1 - 0.23 10.9 10.5 1.2 8.7 1.7 2.5 2 0 0 2 2 2 0 YMGG-like Gly-zipper TraI PF07057.6 KOO20965.1 - 0.24 11.3 7.7 0.77 9.7 0.5 2.4 2 0 0 2 2 2 0 DNA helicase TraI Mnd1 PF03962.10 KOO20965.1 - 2.4 7.7 12.6 0.99 9.0 2.2 2.2 2 0 0 2 2 2 0 Mnd1 family Seryl_tRNA_N PF02403.17 KOO20965.1 - 6.3 6.8 6.8 1.9 8.5 1.0 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain 2OG-FeII_Oxy_2 PF13532.1 KOO20966.1 - 0.093 12.5 0.0 0.14 11.9 0.0 1.5 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Pro_isomerase PF00160.16 KOO20968.1 - 4.5e-30 104.9 0.0 9.5e-30 103.8 0.0 1.6 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD FKBP_C PF00254.23 KOO20968.1 - 1.2e-10 41.2 0.0 2.5e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_11 PF13414.1 KOO20968.1 - 3.6e-07 29.7 8.4 6.2e-05 22.5 0.5 2.8 2 1 1 3 3 3 2 TPR repeat TPR_1 PF00515.23 KOO20968.1 - 5.9e-05 22.5 0.1 0.38 10.4 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO20968.1 - 0.0063 16.3 2.1 2.1 8.4 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO20968.1 - 0.025 14.4 0.0 0.087 12.7 0.0 2.0 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.1 KOO20968.1 - 0.069 12.9 1.8 0.2 11.5 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO20968.1 - 0.12 12.8 3.9 18 6.0 0.0 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO20968.1 - 0.16 11.8 3.3 0.24 11.3 0.6 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO20968.1 - 7.1 7.5 9.4 1.1 10.1 0.3 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TFIIS_C PF01096.13 KOO20969.1 - 2.9e-10 39.6 12.3 7.3e-09 35.1 3.5 3.3 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.11 KOO20969.1 - 9.1e-07 28.4 2.2 9.1e-07 28.4 1.5 2.8 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit GFA PF04828.9 KOO20969.1 - 0.00067 19.5 9.4 0.25 11.2 0.0 3.3 1 1 2 3 3 3 2 Glutathione-dependent formaldehyde-activating enzyme DZR PF12773.2 KOO20969.1 - 0.024 14.4 0.7 0.024 14.4 0.5 3.0 2 1 0 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.1 KOO20969.1 - 0.029 13.5 0.3 0.029 13.5 0.2 2.8 3 1 0 3 3 3 0 zinc-ribbon domain UPF0547 PF10571.4 KOO20969.1 - 0.077 12.7 0.0 0.077 12.7 0.0 2.7 3 1 0 3 3 3 0 Uncharacterised protein family UPF0547 DUF3716 PF12511.3 KOO20969.1 - 0.084 12.4 7.8 1.5 8.4 1.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3716) zinc_ribbon_2 PF13240.1 KOO20969.1 - 0.13 11.7 0.1 0.13 11.7 0.1 3.1 3 1 0 3 3 3 0 zinc-ribbon domain FYVE PF01363.16 KOO20969.1 - 0.21 11.4 0.2 0.21 11.4 0.1 2.4 2 1 0 2 2 2 0 FYVE zinc finger TF_Zn_Ribbon PF08271.7 KOO20969.1 - 0.45 9.8 6.5 9.7 5.6 0.0 3.8 4 0 0 4 4 4 0 TFIIB zinc-binding Zn_Tnp_IS1595 PF12760.2 KOO20969.1 - 1.2 9.0 13.1 4.5 7.1 1.8 2.8 2 1 1 3 3 3 0 Transposase zinc-ribbon domain PhnA_Zn_Ribbon PF08274.7 KOO20969.1 - 1.3 8.8 9.1 2 8.2 0.0 3.7 4 0 0 4 4 4 0 PhnA Zinc-Ribbon Glyco_transf_8 PF01501.15 KOO20970.1 - 4.5e-10 39.3 0.0 4.9e-09 35.8 0.0 2.5 1 1 0 1 1 1 1 Glycosyl transferase family 8 Methyltransf_23 PF13489.1 KOO20971.1 - 0.0001 22.0 0.0 0.00026 20.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Rubi_NSP_C PF12601.3 KOO20971.1 - 0.0014 18.4 0.1 0.058 13.2 0.0 2.3 2 0 0 2 2 2 1 Rubivirus non-structural protein Methyltransf_11 PF08241.7 KOO20971.1 - 0.11 13.0 0.0 0.22 12.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 KOO20971.1 - 0.13 12.7 0.0 0.34 11.4 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Sulfatase PF00884.18 KOO20972.1 - 3.2e-23 82.3 0.0 4.3e-23 81.9 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.1 KOO20973.1 - 0.025 14.8 0.0 0.033 14.4 0.0 1.2 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase Gly-zipper_OmpA PF13436.1 KOO20974.1 - 0.006 16.2 0.1 0.0065 16.1 0.1 1.3 1 0 0 1 1 1 1 Glycine-zipper containing OmpA-like membrane domain CLPTM1 PF05602.7 KOO20977.1 - 3.3e-42 144.7 0.0 4.9e-42 144.1 0.0 1.2 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) MMR_HSR1 PF01926.18 KOO20979.1 - 5.7e-20 71.4 0.0 1.2e-19 70.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP-bdg_N PF13167.1 KOO20979.1 - 1.5e-15 57.0 0.0 3e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 GTP-binding GTPase N-terminal GTP_EFTU PF00009.22 KOO20979.1 - 0.00014 21.4 0.0 0.26 10.7 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 KOO20979.1 - 0.00015 21.6 0.2 0.013 15.3 0.0 2.3 2 0 0 2 2 2 1 Dynamin family cobW PF02492.14 KOO20979.1 - 0.00034 20.1 3.9 0.097 12.1 0.1 2.8 2 1 1 3 3 3 2 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.22 KOO20979.1 - 0.00043 20.5 0.0 0.0011 19.2 0.0 1.7 1 0 0 1 1 1 1 ABC transporter FeoB_N PF02421.13 KOO20979.1 - 0.00068 18.9 0.5 0.0026 17.0 0.3 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B Miro PF08477.8 KOO20979.1 - 0.0012 19.3 0.3 0.0052 17.2 0.1 2.1 2 1 0 2 2 1 1 Miro-like protein MobB PF03205.9 KOO20979.1 - 0.0062 16.2 0.1 0.014 15.1 0.1 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B Arf PF00025.16 KOO20979.1 - 0.011 14.9 0.1 3 7.0 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_16 PF13191.1 KOO20979.1 - 0.018 15.0 1.9 0.045 13.7 0.5 2.2 2 1 0 2 2 2 0 AAA ATPase domain DUF258 PF03193.11 KOO20979.1 - 0.027 13.6 0.0 0.047 12.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ArgK PF03308.11 KOO20979.1 - 0.036 12.8 0.3 0.4 9.4 0.0 2.3 1 1 1 2 2 2 0 ArgK protein AAA_23 PF13476.1 KOO20979.1 - 0.037 14.3 0.2 0.089 13.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 KOO20979.1 - 0.098 12.1 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_14 PF13173.1 KOO20979.1 - 0.1 12.5 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain GBP PF02263.14 KOO20979.1 - 0.16 10.9 0.0 0.26 10.2 0.0 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain RRM_1 PF00076.17 KOO20981.1 - 2.6e-19 68.6 0.9 5.3e-08 32.3 0.0 5.0 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO20981.1 - 9.1e-15 54.2 0.1 2.3e-07 30.5 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO20981.1 - 2.2e-13 49.9 0.0 0.0056 16.6 0.0 3.6 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) tRNA_anti-codon PF01336.20 KOO20981.1 - 0.049 13.4 0.1 1.2 9.0 0.0 2.3 2 0 0 2 2 2 0 OB-fold nucleic acid binding domain SH3_6 PF12913.2 KOO20981.1 - 0.067 12.4 0.0 2.9 7.2 0.0 2.4 2 0 0 2 2 2 0 SH3 domain of the SH3b1 type MIP-T3 PF10243.4 KOO20981.1 - 1.8 6.9 12.3 2.7 6.3 8.5 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 2OG-FeII_Oxy_3 PF13640.1 KOO20983.1 - 1.4e-09 38.3 0.1 3.5e-09 37.0 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO20983.1 - 7.6e-05 22.2 0.0 0.00052 19.6 0.0 2.1 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily HIT PF01230.18 KOO20984.1 - 4.1e-24 84.9 0.0 5.2e-24 84.6 0.0 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 KOO20984.1 - 3.8e-19 69.0 0.0 4.8e-19 68.7 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DUF3638 PF12340.3 KOO20988.1 - 1.6e-17 63.2 0.0 4.5e-17 61.7 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.3 KOO20988.1 - 1.4e-14 52.9 0.2 3.5e-14 51.6 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) ART PF01129.13 KOO20988.1 - 4.8e-12 45.4 0.0 4.3e-11 42.3 0.0 2.3 1 1 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Ank_2 PF12796.2 KOO20988.1 - 8.8e-11 41.9 0.1 1.9e-08 34.5 0.0 4.0 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Thioredoxin PF00085.15 KOO20988.1 - 1.2e-09 37.7 0.1 2.4e-09 36.7 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin EF-hand_6 PF13405.1 KOO20988.1 - 3e-06 26.6 0.1 0.01 15.6 0.1 3.5 3 0 0 3 3 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO20988.1 - 7.8e-05 22.7 0.3 0.00049 20.1 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO20988.1 - 0.0014 17.7 0.7 0.62 9.5 0.0 3.0 2 0 0 2 2 2 2 EF hand Ank_4 PF13637.1 KOO20988.1 - 0.0014 19.0 0.1 0.49 10.9 0.0 4.1 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO20988.1 - 0.0032 17.5 0.0 1.5 9.3 0.0 4.2 4 0 0 4 4 3 1 Ankyrin repeat Ank PF00023.25 KOO20988.1 - 0.12 12.2 2.4 1.8 8.5 0.0 3.9 4 0 0 4 4 4 0 Ankyrin repeat TTL PF03133.10 KOO20989.1 - 8e-53 179.2 0.0 1.2e-52 178.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family NAP PF00956.13 KOO20989.1 - 3.3e-25 88.6 0.0 7.4e-25 87.4 0.0 1.5 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) ATPgrasp_YheCD PF14398.1 KOO20989.1 - 0.012 14.3 0.0 0.02 13.6 0.0 1.3 1 0 0 1 1 1 0 YheC/D like ATP-grasp Glyco_hydro_42 PF02449.10 KOO20989.1 - 0.017 14.2 0.3 0.029 13.4 0.2 1.3 1 0 0 1 1 1 0 Beta-galactosidase Glyco_transf_8 PF01501.15 KOO20990.1 - 1.6e-19 70.2 0.0 2.8e-19 69.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Nucleotid_trans PF03407.11 KOO20990.1 - 0.0015 18.3 0.0 0.0028 17.4 0.0 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Mannosyl_trans3 PF11051.3 KOO20990.1 - 0.05 12.9 0.0 0.081 12.2 0.0 1.2 1 0 0 1 1 1 0 Mannosyltransferase putative PetM PF08041.6 KOO20990.1 - 0.17 11.3 0.0 0.31 10.5 0.0 1.4 1 0 0 1 1 1 0 PetM family of cytochrome b6f complex subunit 7 Glyco_transf_8 PF01501.15 KOO20991.1 - 3.8e-08 32.9 0.0 3.2e-07 29.9 0.0 2.5 1 1 0 1 1 1 1 Glycosyl transferase family 8 Cellulase PF00150.13 KOO20992.1 - 1.8e-07 30.6 0.6 3e-07 29.9 0.4 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) AP_endonuc_2 PF01261.19 KOO20992.1 - 0.00019 20.7 0.0 0.0019 17.5 0.0 2.3 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel MORN PF02493.15 KOO20993.1 - 7.2e-63 204.7 75.0 9.3e-08 31.3 0.9 10.8 11 0 0 11 11 11 10 MORN repeat DUF448 PF04296.8 KOO20993.1 - 0.027 14.1 4.1 18 5.0 0.1 4.2 2 1 1 4 4 4 0 Protein of unknown function (DUF448) EF-hand_9 PF14658.1 KOO20994.1 - 0.14 12.1 0.1 2.3 8.2 0.0 2.9 4 0 0 4 4 4 0 EF-hand domain Pkinase PF00069.20 KOO20995.1 - 9.6e-30 103.5 0.0 1.3e-29 103.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO20995.1 - 2.5e-20 72.6 0.0 3.7e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 KOO20995.1 - 0.01 15.1 0.0 0.016 14.5 0.0 1.2 1 0 0 1 1 1 0 RIO1 family APH PF01636.18 KOO20995.1 - 0.039 13.6 0.1 0.061 13.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family EF-hand_1 PF00036.27 KOO20996.1 - 1.1e-10 40.0 1.4 5.4e-05 22.2 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO20996.1 - 2.8e-09 36.9 0.1 6.8e-09 35.7 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO20996.1 - 1.2e-08 34.0 2.5 0.00026 20.6 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO20996.1 - 8.5e-08 31.7 0.0 1.6e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO20996.1 - 4.3e-06 25.8 2.5 0.049 13.0 0.2 2.4 2 0 0 2 2 2 2 EF hand TTL PF03133.10 KOO20997.1 - 3e-73 246.3 0.0 5e-73 245.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 KOO20997.1 - 0.0011 17.7 0.0 0.89 8.2 0.0 2.3 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATP-grasp_4 PF13535.1 KOO20997.1 - 0.068 12.8 0.0 0.19 11.4 0.0 1.8 1 0 0 1 1 1 0 ATP-grasp domain Pkinase PF00069.20 KOO20998.1 - 2.9e-52 177.3 0.0 5.1e-52 176.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO20998.1 - 5.1e-30 104.4 0.0 9.3e-30 103.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase cNMP_binding PF00027.24 KOO20998.1 - 3.3e-10 39.6 0.0 1.1e-09 37.9 0.0 1.8 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Kdo PF06293.9 KOO20998.1 - 0.0002 20.4 0.0 0.00037 19.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 KOO20998.1 - 0.00052 19.0 0.0 0.00079 18.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO20998.1 - 0.031 13.9 0.0 0.15 11.7 0.0 2.0 2 1 0 2 2 2 0 Phosphotransferase enzyme family LMWPc PF01451.16 KOO20999.1 - 8.7e-22 77.9 0.0 1.1e-21 77.6 0.0 1.1 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase FAP PF07174.6 KOO21001.1 - 0.059 12.6 12.0 0.074 12.3 8.3 1.3 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) EF-hand_1 PF00036.27 KOO21002.1 - 1.4e-18 64.6 2.4 2.2e-05 23.4 0.0 3.9 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.1 KOO21002.1 - 3.2e-17 62.4 3.7 5.1e-12 45.7 1.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO21002.1 - 5.3e-16 57.0 5.4 2e-05 24.1 0.0 3.8 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.1 KOO21002.1 - 1.3e-13 50.3 4.2 3.5e-08 32.9 0.4 3.6 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO21002.1 - 1.4e-11 43.1 4.6 0.0023 17.1 0.2 3.8 3 0 0 3 3 3 3 EF hand EF-hand_10 PF14788.1 KOO21002.1 - 2.4e-06 27.1 1.7 0.00041 19.9 0.2 3.2 2 1 1 3 3 3 1 EF hand Arm PF00514.18 KOO21002.1 - 0.00094 18.9 44.9 0.0037 17.0 0.1 11.0 13 0 0 13 13 13 3 Armadillo/beta-catenin-like repeat EF-hand_4 PF12763.2 KOO21002.1 - 0.0051 16.5 0.3 7.7 6.3 0.0 3.3 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand Atx10homo_assoc PF09759.4 KOO21002.1 - 0.067 12.9 1.4 9.6 6.0 0.0 4.2 2 2 1 4 4 4 0 Spinocerebellar ataxia type 10 protein domain p25-alpha PF05517.7 KOO21002.1 - 0.16 12.2 0.7 0.35 11.1 0.2 1.8 2 0 0 2 2 2 0 p25-alpha DSBA PF01323.15 KOO21003.1 - 0.029 13.9 0.0 1.6 8.2 0.0 2.5 2 1 0 2 2 2 0 DSBA-like thioredoxin domain Kinesin PF00225.18 KOO21004.1 - 3.6e-118 394.1 0.0 4.5e-118 393.7 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain PIF1 PF05970.9 KOO21004.1 - 0.013 14.4 0.1 0.021 13.8 0.1 1.2 1 0 0 1 1 1 0 PIF1-like helicase DoxX PF07681.7 KOO21004.1 - 0.87 10.0 12.9 0.053 13.9 3.3 2.7 2 0 0 2 2 2 0 DoxX RF-1 PF00472.15 KOO21005.1 - 5.1e-36 122.9 0.2 9.1e-36 122.1 0.1 1.3 1 0 0 1 1 1 1 RF-1 domain PCRF PF03462.13 KOO21005.1 - 1.5e-24 85.8 0.0 3.5e-24 84.7 0.0 1.6 1 0 0 1 1 1 1 PCRF domain FKBP_C PF00254.23 KOO21005.1 - 5.9e-10 39.0 0.1 3.2e-09 36.6 0.0 2.1 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase Filamin PF00630.14 KOO21006.1 - 3.3e-40 136.7 0.0 5.2e-15 55.8 0.0 6.0 5 1 0 5 5 5 5 Filamin/ABP280 repeat YtkA PF13115.1 KOO21006.1 - 0.005 17.1 0.0 14 6.1 0.0 4.7 4 0 0 4 4 4 1 YtkA-like DUF218 PF02698.12 KOO21006.1 - 0.16 11.4 0.0 0.36 10.3 0.0 1.5 1 0 0 1 1 1 0 DUF218 domain Big_3_4 PF13754.1 KOO21006.1 - 0.92 9.8 7.9 27 5.1 1.2 4.4 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 3) Eapp_C PF10238.4 KOO21007.1 - 0.11 12.4 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein IBN_N PF03810.14 KOO21008.1 - 2.4e-13 49.7 0.0 1.3e-12 47.4 0.0 2.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain Cse1 PF08506.5 KOO21008.1 - 6.3e-07 28.2 0.0 2.7e-05 22.9 0.0 2.3 2 0 0 2 2 2 1 Cse1 Xpo1 PF08389.7 KOO21008.1 - 0.0024 17.7 0.0 0.031 14.2 0.0 2.6 2 1 1 3 3 3 1 Exportin 1-like protein RIX1 PF08167.7 KOO21008.1 - 0.031 13.9 0.0 16 5.1 0.0 3.3 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis DUF2435 PF10363.4 KOO21008.1 - 0.081 12.8 0.1 0.33 10.8 0.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2435) TFIID_30kDa PF03540.8 KOO21010.1 - 6.8e-05 22.6 0.0 0.00012 21.8 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit ER_lumen_recept PF00810.13 KOO21013.1 - 8.7e-54 182.0 3.0 1.3e-53 181.4 2.1 1.3 1 0 0 1 1 1 1 ER lumen protein retaining receptor Enkurin PF13864.1 KOO21014.1 - 8.4e-19 67.5 0.9 1.6e-18 66.7 0.1 1.8 2 0 0 2 2 2 1 Calmodulin-binding SPX PF03105.14 KOO21016.1 - 6.7e-17 62.1 0.9 2.8e-06 27.3 0.2 3.9 2 1 1 3 3 3 2 SPX domain Zn_clus PF00172.13 KOO21016.1 - 0.0036 17.1 12.4 0.0036 17.1 8.6 1.9 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cwf_Cwc_15 PF04889.7 KOO21017.1 - 0.22 11.1 14.5 0.057 13.1 2.2 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF2201_N PF13203.1 KOO21017.1 - 7.9 5.5 13.3 0.07 12.3 1.0 2.2 2 0 0 2 2 2 0 Putative metallopeptidase domain WD40 PF00400.27 KOO21018.1 - 0.00049 19.8 6.3 0.43 10.5 0.1 4.1 5 0 0 5 5 5 2 WD domain, G-beta repeat Nup160 PF11715.3 KOO21018.1 - 0.025 12.7 0.0 0.032 12.3 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 PQQ_3 PF13570.1 KOO21018.1 - 1.1 9.6 6.3 1.2 9.5 0.1 3.7 4 0 0 4 4 4 0 PQQ-like domain DegT_DnrJ_EryC1 PF01041.12 KOO21019.1 - 8e-40 136.9 0.1 9.8e-40 136.6 0.1 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family PHD PF00628.24 KOO21020.1 - 0.00083 18.9 8.0 0.00083 18.9 5.6 3.0 3 0 0 3 3 3 1 PHD-finger zf-HC5HC2H_2 PF13832.1 KOO21020.1 - 0.012 15.6 1.8 0.012 15.6 1.2 2.0 2 0 0 2 2 2 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 KOO21020.1 - 0.018 15.1 4.0 0.018 15.1 2.8 2.0 2 0 0 2 2 2 0 PHD-like zinc-binding domain C1_1 PF00130.17 KOO21020.1 - 0.047 13.4 7.9 0.65 9.7 0.1 3.8 3 1 1 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) UPF0113 PF03657.8 KOO21022.1 - 2.4e-07 30.5 0.0 3.6e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0113) Nol1_Nop2_Fmu_2 PF13636.1 KOO21022.1 - 0.0028 17.7 0.0 0.0053 16.8 0.0 1.5 1 0 0 1 1 1 1 pre-rRNA processing and ribosome biogenesis PUA PF01472.15 KOO21022.1 - 0.055 13.1 0.0 0.099 12.3 0.0 1.4 1 0 0 1 1 1 0 PUA domain Bestrophin PF01062.16 KOO21025.1 - 6.5e-36 123.7 2.6 9.4e-36 123.2 1.8 1.2 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel EF-hand_6 PF13405.1 KOO21025.1 - 8.1e-13 47.0 0.5 2.8e-06 26.7 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO21025.1 - 2.7e-12 45.0 1.9 6.7e-07 28.1 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO21025.1 - 6.6e-11 42.1 0.2 1.8e-10 40.8 0.1 1.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO21025.1 - 4.3e-09 35.8 0.2 1e-08 34.6 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO21025.1 - 2.3e-08 32.9 0.5 0.0011 18.1 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.1 KOO21025.1 - 0.00042 19.9 1.2 0.0011 18.6 0.2 2.1 1 1 1 2 2 2 2 EF hand LIM PF00412.17 KOO21026.1 - 1.7e-12 47.1 7.9 2.1e-08 34.1 2.6 2.4 2 0 0 2 2 2 2 LIM domain Prok-RING_1 PF14446.1 KOO21026.1 - 0.0045 16.6 8.5 0.089 12.5 0.2 2.9 2 1 0 2 2 2 2 Prokaryotic RING finger family 1 zf-dskA_traR PF01258.12 KOO21026.1 - 0.2 11.3 6.7 0.57 9.9 0.1 3.7 3 0 0 3 3 3 0 Prokaryotic dksA/traR C4-type zinc finger PNP_UDP_1 PF01048.15 KOO21027.1 - 5.1e-23 81.2 4.2 6.6e-23 80.9 2.9 1.2 1 0 0 1 1 1 1 Phosphorylase superfamily ACBP PF00887.14 KOO21028.1 - 1.9e-16 59.5 0.0 3e-16 58.8 0.0 1.3 1 0 0 1 1 1 1 Acyl CoA binding protein Choline_kinase PF01633.15 KOO21028.1 - 0.022 14.3 0.0 0.035 13.6 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.18 KOO21028.1 - 0.034 13.8 0.0 0.034 13.8 0.0 2.9 2 1 0 2 2 2 0 Phosphotransferase enzyme family Phasin_2 PF09361.5 KOO21028.1 - 0.071 13.1 3.5 0.18 11.8 2.5 1.7 1 0 0 1 1 1 0 Phasin protein UvrD-helicase PF00580.16 KOO21029.1 - 2.9e-09 36.6 0.0 4.3e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.1 KOO21029.1 - 1.8e-06 27.7 0.0 3.1e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.1 KOO21029.1 - 0.00021 21.4 0.0 0.082 13.0 0.0 2.5 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.13 KOO21029.1 - 0.007 15.9 0.0 0.49 9.8 0.0 2.9 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase PhoH PF02562.11 KOO21029.1 - 0.017 14.3 0.0 0.029 13.6 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein IFT57 PF10498.4 KOO21029.1 - 0.047 12.4 0.0 0.088 11.5 0.0 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 VDE PF07137.6 KOO21030.1 - 1.2e-15 57.8 0.0 5.1e-14 52.5 0.0 2.4 1 1 0 1 1 1 1 Violaxanthin de-epoxidase (VDE) Peptidase_S10 PF00450.17 KOO21031.1 - 2.7e-86 290.3 0.0 3.2e-86 290.0 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase DUF1765 PF08578.5 KOO21032.1 - 2.1e-19 69.7 0.1 4.3e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) FPN1 PF06963.7 KOO21033.1 - 1.4e-44 152.2 12.4 1.8e-28 99.0 4.0 2.1 1 1 1 2 2 2 2 Ferroportin1 (FPN1) Chloroa_b-bind PF00504.16 KOO21034.1 - 2.4e-29 102.6 1.9 4e-27 95.3 1.3 2.8 1 1 0 1 1 1 1 Chlorophyll A-B binding protein TauD PF02668.11 KOO21036.1 - 9.8e-30 104.0 0.3 1.6e-29 103.4 0.2 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family EF-hand_1 PF00036.27 KOO21037.1 - 9.9e-19 65.1 0.5 0.00047 19.2 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO21037.1 - 3.9e-18 65.3 2.6 9.4e-07 28.8 0.1 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO21037.1 - 4.9e-16 57.1 0.7 0.0078 16.0 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO21037.1 - 2.4e-11 42.4 5.8 0.0011 18.2 0.1 5.2 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.1 KOO21037.1 - 4.8e-05 22.8 0.3 2.7 7.6 0.0 4.0 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_10 PF14788.1 KOO21037.1 - 0.017 14.8 0.6 12 5.5 0.0 3.5 3 0 0 3 3 3 0 EF hand Virulence_fact PF13769.1 KOO21037.1 - 0.071 12.9 1.1 1.9 8.4 0.0 2.9 2 1 0 2 2 2 0 Virulence factor Peptidase_M10 PF00413.19 KOO21038.1 - 0.00048 19.8 0.0 0.0036 17.0 0.0 2.1 1 1 0 1 1 1 1 Matrixin Astacin PF01400.19 KOO21038.1 - 0.013 14.9 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Peptidase_M57 PF12388.3 KOO21038.1 - 0.2 10.9 0.0 0.32 10.2 0.0 1.2 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Peptidase_C1 PF00112.18 KOO21039.1 - 2.4e-39 135.4 8.2 3.6e-39 134.9 5.6 1.2 1 0 0 1 1 1 1 Papain family cysteine protease DUF3932 PF13068.1 KOO21039.1 - 0.089 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3932) Amidase PF01425.16 KOO21040.1 - 1.3e-78 264.7 0.1 2.8e-78 263.7 0.1 1.5 1 1 0 1 1 1 1 Amidase TPR_11 PF13414.1 KOO21041.1 - 2.1e-11 43.3 0.5 6.5e-11 41.7 0.3 1.9 1 0 0 1 1 1 1 TPR repeat TPR_17 PF13431.1 KOO21041.1 - 2.8e-09 36.4 0.4 0.00081 19.4 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO21041.1 - 4.9e-08 32.3 0.5 0.00039 20.1 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO21041.1 - 9.1e-08 31.4 0.1 1.1e-05 24.7 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOO21041.1 - 3.9e-06 26.7 0.0 1.1e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO21041.1 - 0.00014 22.1 4.1 0.00063 20.1 0.5 3.6 2 1 2 4 4 3 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO21041.1 - 0.00082 19.1 1.3 0.0023 17.7 0.9 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat Apc3 PF12895.2 KOO21041.1 - 0.0031 17.6 0.0 0.0081 16.2 0.0 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 KOO21041.1 - 0.0089 15.7 0.0 0.063 13.0 0.0 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO21041.1 - 0.023 14.4 0.1 0.37 10.7 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 KOO21041.1 - 0.037 14.3 1.9 0.037 14.3 1.3 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 KOO21041.1 - 0.041 13.8 1.5 0.29 11.1 0.2 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.1 KOO21041.1 - 0.17 12.5 18.8 0.11 13.2 4.4 3.7 2 1 0 3 3 3 0 Tetratricopeptide repeat DUF778 PF05608.7 KOO21042.1 - 6.8e-18 64.9 0.0 6.8e-17 61.6 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF778) Tctex-1 PF03645.8 KOO21044.1 - 1.3e-26 92.3 0.0 1.7e-26 92.0 0.0 1.1 1 0 0 1 1 1 1 Tctex-1 family PG_binding_1 PF01471.13 KOO21045.1 - 5e-23 80.8 0.3 9.1e-08 31.9 0.0 3.7 3 0 0 3 3 3 3 Putative peptidoglycan binding domain PG_binding_3 PF09374.5 KOO21045.1 - 1.9e-10 40.5 3.6 0.13 12.2 0.0 5.6 3 2 2 5 5 5 4 Predicted Peptidoglycan domain Popeye PF04831.8 KOO21045.1 - 4.1e-10 39.6 0.0 1.3e-09 37.9 0.0 1.8 2 0 0 2 2 2 1 Popeye protein conserved region cNMP_binding PF00027.24 KOO21045.1 - 6.5e-08 32.2 0.0 1.7e-07 30.9 0.0 1.8 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Med3 PF11593.3 KOO21045.1 - 2.3 7.3 7.8 4.5 6.4 5.4 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal 3Beta_HSD PF01073.14 KOO21046.1 - 2.2e-40 138.1 0.0 3.1e-40 137.6 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 KOO21046.1 - 8.3e-29 100.6 0.0 1.2e-28 100.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 KOO21046.1 - 1.5e-17 63.4 1.9 4.5e-15 55.2 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein adh_short PF00106.20 KOO21046.1 - 1.9e-11 44.1 0.2 3.2e-11 43.4 0.2 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Polyketide_cyc2 PF10604.4 KOO21046.1 - 4.5e-11 43.0 0.6 1.2e-10 41.7 0.4 1.6 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport RmlD_sub_bind PF04321.12 KOO21046.1 - 7.5e-10 38.1 0.0 1.2e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Polyketide_cyc PF03364.15 KOO21046.1 - 6e-08 32.7 0.1 1.1e-07 31.8 0.1 1.4 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport KR PF08659.5 KOO21046.1 - 1e-05 25.2 0.1 1.7e-05 24.5 0.1 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 KOO21046.1 - 1.6e-05 24.9 1.7 1.7e-05 24.8 0.2 1.8 2 1 0 2 2 2 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 KOO21046.1 - 3.8e-05 22.7 0.0 0.00031 19.7 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein AHSA1 PF08327.6 KOO21046.1 - 0.0021 18.1 0.0 0.0042 17.1 0.0 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Methyltransf_21 PF05050.7 KOO21047.1 - 1.8e-11 44.3 0.0 2.7e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain FKBP_C PF00254.23 KOO21048.1 - 9.6e-17 60.7 0.0 1.8e-16 59.8 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.13 KOO21048.1 - 1.4e-08 34.7 0.0 3.6e-08 33.4 0.0 1.7 1 0 0 1 1 1 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Na_Ca_ex PF01699.19 KOO21049.1 - 4.5e-11 42.5 24.0 3.6e-08 33.0 8.6 2.7 2 1 0 2 2 2 2 Sodium/calcium exchanger protein EF-hand_7 PF13499.1 KOO21049.1 - 5.3e-11 42.4 0.1 1.1e-10 41.4 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO21049.1 - 8.6e-09 34.0 1.1 0.00043 19.3 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO21049.1 - 1.4e-08 33.9 0.9 0.00022 20.8 0.2 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.1 KOO21049.1 - 4.6e-07 28.8 0.1 0.0093 15.2 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO21049.1 - 4.1e-05 23.0 0.4 0.00014 21.3 0.1 2.1 1 1 1 2 2 2 2 EF-hand domain pair YoqO PF14037.1 KOO21049.1 - 1.1 9.4 6.7 0.18 11.9 1.4 2.1 2 0 0 2 2 2 0 YoqO-like protein ZZ PF00569.12 KOO21050.1 - 2.2e-07 30.3 0.7 3.1e-07 29.8 0.5 1.2 1 0 0 1 1 1 1 Zinc finger, ZZ type NAPRTase PF04095.11 KOO21051.1 - 0.055 12.7 0.0 0.5 9.6 0.0 2.1 1 1 0 1 1 1 0 Nicotinate phosphoribosyltransferase (NAPRTase) family Choline_transpo PF04515.7 KOO21053.1 - 1.9e-54 184.6 34.7 1.9e-54 184.6 24.0 2.0 2 0 0 2 2 2 1 Plasma-membrane choline transporter DUF2590 PF10761.4 KOO21054.1 - 0.48 10.1 4.0 0.2 11.3 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2590) RimM PF01782.13 KOO21054.1 - 0.89 9.5 6.1 0.47 10.3 1.7 2.5 2 0 0 2 2 2 0 RimM N-terminal domain Ribosomal_L12 PF00542.14 KOO21055.1 - 4.8e-10 39.3 8.0 4.8e-10 39.3 5.6 2.1 1 1 1 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain IL3 PF02059.10 KOO21055.1 - 0.034 14.1 0.1 0.06 13.3 0.1 1.3 1 1 0 1 1 1 0 Interleukin-3 Paf1 PF03985.8 KOO21055.1 - 0.038 12.7 0.2 0.043 12.5 0.1 1.0 1 0 0 1 1 1 0 Paf1 RCC1 PF00415.13 KOO21056.1 - 1.3e-21 76.5 4.2 0.00014 22.0 0.0 6.1 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO21056.1 - 2.8e-15 55.4 23.0 0.00016 21.1 0.4 6.1 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat TIMELESS PF04821.9 KOO21057.1 - 3.6e-27 95.2 0.0 4.8e-27 94.8 0.0 1.1 1 0 0 1 1 1 1 Timeless protein TIMELESS_C PF05029.8 KOO21058.1 - 3.4e-15 56.0 0.2 3.4e-15 56.0 0.1 3.6 3 1 0 4 4 4 1 Timeless protein C terminal region Myb_DNA-bind_6 PF13921.1 KOO21058.1 - 0.0018 18.3 0.0 0.0038 17.3 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Ank_2 PF12796.2 KOO21059.1 - 1.8e-20 73.0 0.8 2.9e-15 56.3 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) DnaJ PF00226.26 KOO21059.1 - 1.2e-19 69.7 0.1 2.5e-19 68.7 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain Ank PF00023.25 KOO21059.1 - 2.2e-16 58.7 2.5 7.3e-06 25.5 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 KOO21059.1 - 3.5e-15 55.6 0.9 2.7e-08 33.8 0.1 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO21059.1 - 2e-13 50.4 0.2 1.7e-08 34.7 0.0 2.9 2 1 1 3 3 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO21059.1 - 1.1e-10 40.6 0.1 0.0012 18.9 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat TPR_2 PF07719.12 KOO21059.1 - 2.1e-10 39.7 4.8 0.012 15.5 0.1 4.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.1 KOO21059.1 - 5.2e-09 35.6 6.3 2.7e-06 26.9 1.4 2.9 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 KOO21059.1 - 1.8e-07 30.4 2.0 0.03 13.9 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO21059.1 - 9.4e-06 25.4 4.3 0.00069 19.5 0.2 3.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO21059.1 - 0.00043 19.8 0.3 0.1 12.4 0.0 2.8 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO21059.1 - 0.0016 19.0 5.2 0.0016 19.0 3.6 5.8 6 0 0 6 6 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO21059.1 - 0.0068 16.7 0.2 0.0068 16.7 0.2 3.8 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO21059.1 - 0.041 13.6 2.8 1.2 9.1 0.0 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat AAA_13 PF13166.1 KOO21059.1 - 5.5 5.3 6.5 7.9 4.8 4.5 1.1 1 0 0 1 1 1 0 AAA domain Tropomyosin_1 PF12718.2 KOO21059.1 - 7.2 6.4 20.9 29 4.4 0.1 2.8 2 1 0 2 2 2 0 Tropomyosin like TPR_11 PF13414.1 KOO21060.1 - 2.2e-17 62.4 9.4 5.8e-08 32.2 0.9 3.6 1 1 1 3 3 3 3 TPR repeat TPR_17 PF13431.1 KOO21060.1 - 2.3e-15 55.4 1.4 3.9e-05 23.4 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO21060.1 - 8.9e-13 47.2 6.7 0.0007 19.1 0.1 5.1 4 1 0 4 4 4 4 Tetratricopeptide repeat TPR_16 PF13432.1 KOO21060.1 - 6.9e-12 45.7 10.3 7e-06 26.5 0.4 3.7 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO21060.1 - 1.3e-11 43.4 12.8 0.0095 15.7 0.1 5.2 5 1 0 5 5 4 4 Tetratricopeptide repeat TPR_12 PF13424.1 KOO21060.1 - 2.7e-10 40.0 6.9 2.2e-07 30.7 0.3 3.4 1 1 2 3 3 3 3 Tetratricopeptide repeat 2OG-FeII_Oxy_3 PF13640.1 KOO21060.1 - 8e-09 35.9 0.1 1.5e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TPR_19 PF14559.1 KOO21060.1 - 5.2e-07 29.9 8.9 0.006 16.9 0.9 3.4 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO21060.1 - 7.2e-07 28.5 2.5 0.58 10.0 0.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO21060.1 - 0.00025 21.4 13.5 0.099 13.3 0.1 5.1 3 1 3 6 6 5 3 Tetratricopeptide repeat 2OG-FeII_Oxy PF03171.15 KOO21060.1 - 0.00099 19.3 0.0 0.0026 18.0 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TPR_10 PF13374.1 KOO21060.1 - 0.042 13.7 8.6 9 6.3 0.4 4.7 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.9 KOO21060.1 - 0.063 13.7 4.2 8.8 7.0 0.0 4.4 3 2 1 4 4 3 0 Tetratricopeptide repeat Mago-bind PF09282.5 KOO21060.1 - 0.16 11.5 0.0 0.39 10.3 0.0 1.6 1 0 0 1 1 1 0 Mago binding TPR_7 PF13176.1 KOO21060.1 - 0.64 9.9 3.2 6.6 6.7 0.0 3.9 4 2 0 4 4 4 0 Tetratricopeptide repeat SPRR2 PF14820.1 KOO21061.1 - 1.9 8.4 7.2 1 9.3 1.5 2.3 2 0 0 2 2 2 0 Small proline-rich 2 Peptidase_M16 PF00675.15 KOO21062.1 - 3.5e-55 185.8 0.2 5.7e-55 185.1 0.2 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 KOO21062.1 - 1.4e-30 106.3 0.0 2.3e-29 102.4 0.0 2.1 2 0 0 2 2 2 1 Peptidase M16 inactive domain M16C_assoc PF08367.6 KOO21062.1 - 0.054 12.3 0.0 0.11 11.2 0.0 1.5 1 0 0 1 1 1 0 Peptidase M16C associated V-SNARE_C PF12352.3 KOO21063.1 - 3.4e-14 52.6 0.6 3.4e-14 52.6 0.4 1.9 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.10 KOO21063.1 - 9.6e-12 44.9 3.5 3.9e-11 42.9 0.2 2.7 2 1 1 3 3 3 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.8 KOO21063.1 - 7.8e-05 22.3 0.1 0.00019 21.0 0.0 1.6 1 0 0 1 1 1 1 Sec20 TMF_TATA_bd PF12325.3 KOO21063.1 - 0.0089 15.7 2.0 1.6 8.5 0.2 2.4 2 1 0 2 2 2 2 TATA element modulatory factor 1 TATA binding DUF4407 PF14362.1 KOO21063.1 - 0.019 13.9 0.9 0.027 13.4 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4337 PF14235.1 KOO21063.1 - 0.054 13.3 0.6 0.64 9.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) ODV-E18 PF10717.4 KOO21063.1 - 0.059 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Mnd1 PF03962.10 KOO21063.1 - 0.075 12.6 0.3 0.075 12.6 0.2 1.5 2 0 0 2 2 2 0 Mnd1 family HR1 PF02185.11 KOO21063.1 - 0.094 12.4 2.3 0.11 12.2 0.2 2.1 2 0 0 2 2 2 0 Hr1 repeat TPR_MLP1_2 PF07926.7 KOO21063.1 - 0.098 12.3 3.4 5.2 6.8 0.2 2.4 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein DivIC PF04977.10 KOO21063.1 - 0.1 12.1 1.1 0.15 11.5 0.1 1.8 2 0 0 2 2 2 0 Septum formation initiator IncA PF04156.9 KOO21063.1 - 1.5 8.3 6.2 0.36 10.3 0.9 2.4 2 1 0 2 2 2 0 IncA protein PseudoU_synth_2 PF00849.17 KOO21064.1 - 6.8e-13 48.7 0.0 1e-12 48.1 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.20 KOO21064.1 - 1.2e-08 34.2 0.2 3.5e-08 32.7 0.2 1.9 1 0 0 1 1 1 1 S4 domain ThiS PF02597.15 KOO21064.1 - 0.1 13.0 0.0 0.28 11.6 0.0 1.7 1 0 0 1 1 1 0 ThiS family Pkinase PF00069.20 KOO21066.1 - 3.3e-57 193.5 0.0 2.6e-39 134.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21066.1 - 2.5e-29 102.1 0.0 2.4e-24 85.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 KOO21066.1 - 4.1e-06 26.7 0.3 0.0085 15.8 0.0 2.8 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.17 KOO21066.1 - 0.0046 16.3 0.0 0.009 15.3 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 KOO21066.1 - 0.014 14.3 0.1 0.62 8.9 0.0 2.6 3 0 0 3 3 3 0 Kinase-like ABC1 PF03109.11 KOO21066.1 - 0.029 14.3 0.0 3 7.8 0.0 2.4 2 0 0 2 2 2 0 ABC1 family LRR_6 PF13516.1 KOO21067.1 - 3.4e-20 69.7 0.0 0.0012 18.6 0.0 6.6 6 0 0 6 6 6 6 Leucine Rich repeat LRR_4 PF12799.2 KOO21067.1 - 5.2e-06 25.9 0.0 2 8.1 0.0 4.1 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO21067.1 - 0.079 12.7 0.3 7.5 6.3 0.0 3.3 2 1 2 4 4 4 0 Leucine rich repeat TPR_11 PF13414.1 KOO21068.1 - 7.6e-10 38.3 3.7 7.6e-10 38.3 2.6 2.2 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.12 KOO21068.1 - 4.8e-06 26.0 2.3 0.0051 16.6 0.1 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO21068.1 - 0.00024 20.6 0.3 0.54 10.1 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO21068.1 - 0.0041 16.9 0.4 0.0041 16.9 0.3 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO21068.1 - 0.012 16.2 2.5 0.012 16.2 1.7 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOO21068.1 - 0.037 13.6 5.2 0.99 9.1 0.2 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.1 KOO21068.1 - 0.1 12.8 0.0 0.36 11.1 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF4440 PF14534.1 KOO21070.1 - 0.065 13.4 0.0 0.15 12.2 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4440) zf-TFIIIC PF12660.2 KOO21070.1 - 0.091 12.6 0.1 0.18 11.7 0.0 1.5 1 1 1 2 2 2 0 Putative zinc-finger of transcription factor IIIC complex Aldo_ket_red PF00248.16 KOO21071.1 - 4.9e-14 51.8 0.0 5.8e-14 51.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family TPR_11 PF13414.1 KOO21072.1 - 2.2e-23 81.6 1.4 5.4e-16 58.0 0.0 2.3 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 KOO21072.1 - 5.2e-18 63.8 0.0 1.1e-06 27.9 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO21072.1 - 3.2e-14 51.6 0.7 1.3e-05 24.7 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOO21072.1 - 3.3e-06 26.9 0.4 0.00016 21.5 0.0 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOO21072.1 - 7.2e-06 25.7 5.7 0.057 13.2 1.6 2.6 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOO21072.1 - 3.2e-05 24.1 5.7 0.49 11.1 1.6 3.3 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO21072.1 - 0.00011 21.7 0.2 0.00089 18.8 0.0 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO21072.1 - 0.00027 20.9 0.2 0.19 11.9 0.1 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO21072.1 - 0.0013 19.3 6.4 1 10.1 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_15 PF13429.1 KOO21072.1 - 0.006 15.6 0.8 0.48 9.4 0.7 2.7 1 1 1 2 2 2 1 Tetratricopeptide repeat Baculo_VP39 PF04501.7 KOO21072.1 - 0.013 14.5 0.0 0.016 14.2 0.0 1.1 1 0 0 1 1 1 0 Baculovirus major capsid protein VP39 TPR_6 PF13174.1 KOO21072.1 - 0.033 14.6 0.2 15 6.3 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOO21072.1 - 0.066 13.0 0.0 5.1 7.1 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Mito_fiss_reg PF05308.6 KOO21072.1 - 0.089 12.1 3.6 0.039 13.3 0.8 1.7 2 0 0 2 2 2 0 Mitochondrial fission regulator MIT PF04212.13 KOO21072.1 - 0.11 12.4 2.8 0.44 10.4 0.0 2.7 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain CAP_N PF01213.14 KOO21072.1 - 1.1 8.4 5.1 1.5 7.9 2.6 1.8 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Dus PF01207.12 KOO21073.1 - 0.043 12.6 2.3 0.095 11.5 0.0 2.0 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) Nup54 PF13874.1 KOO21073.1 - 0.1 12.2 4.4 0.39 10.3 1.5 2.5 2 1 0 2 2 2 0 Nucleoporin complex subunit 54 DASH_Dad2 PF08654.5 KOO21073.1 - 0.25 11.3 3.7 0.69 9.9 0.6 2.4 2 0 0 2 2 2 0 DASH complex subunit Dad2 DUF2317 PF10079.4 KOO21073.1 - 0.26 9.8 3.9 0.31 9.5 1.6 1.8 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2317) DUF972 PF06156.8 KOO21073.1 - 0.29 11.4 4.1 2 8.7 0.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF972) SlyX PF04102.7 KOO21073.1 - 1.3 9.4 9.8 1.1 9.7 0.2 2.8 3 0 0 3 3 3 0 SlyX BLOC1_2 PF10046.4 KOO21073.1 - 1.6 8.9 4.8 24 5.1 0.1 2.7 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 cwf21 PF08312.7 KOO21073.1 - 1.7 8.5 6.1 0.43 10.4 0.4 2.5 2 1 1 3 3 3 0 cwf21 domain HpaP PF09483.5 KOO21075.1 - 0.16 11.8 1.5 0.22 11.4 1.1 1.1 1 0 0 1 1 1 0 Type III secretion protein (HpaP) Seryl_tRNA_N PF02403.17 KOO21076.1 - 0.12 12.4 1.0 0.33 10.9 0.4 2.0 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain FAST_1 PF06743.10 KOO21077.1 - 8e-07 28.6 3.3 0.0078 15.8 0.0 4.1 2 1 3 5 5 5 3 FAST kinase-like protein, subdomain 1 P22_AR_C PF10548.4 KOO21077.1 - 0.16 11.8 0.2 4 7.3 0.0 3.1 4 0 0 4 4 4 0 P22AR C-terminal domain Peptidase_C1 PF00112.18 KOO21077.1 - 0.49 10.2 2.0 22 4.8 0.1 2.8 1 1 2 3 3 3 0 Papain family cysteine protease DUF1601 PF07671.6 KOO21077.1 - 0.86 9.2 3.8 34 4.1 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1601) DUF3357 PF11837.3 KOO21078.1 - 0.24 11.2 1.0 0.67 9.8 0.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3357) Ank PF00023.25 KOO21080.1 - 7.5e-24 82.3 12.1 9.6e-09 34.6 0.2 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.2 KOO21080.1 - 8.6e-24 83.6 2.6 1.6e-23 82.8 1.8 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO21080.1 - 1.8e-23 82.0 16.4 5.4e-11 42.3 1.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO21080.1 - 1e-20 73.6 5.4 4.5e-11 42.9 0.3 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO21080.1 - 2.4e-17 61.3 6.1 6.7e-06 25.8 0.1 3.7 3 0 0 3 3 3 3 Ankyrin repeat ACBP PF00887.14 KOO21080.1 - 1.3e-16 59.9 0.0 2.8e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein MOR2-PAG1_N PF14222.1 KOO21081.1 - 0.011 14.5 0.1 0.019 13.6 0.0 1.3 1 0 0 1 1 1 0 Cell morphogenesis N-terminal UVR PF02151.14 KOO21082.1 - 1.4e-07 30.7 5.3 2.2e-07 30.1 3.7 1.3 1 0 0 1 1 1 1 UvrB/uvrC motif DUF4618 PF15397.1 KOO21082.1 - 0.00091 18.6 0.1 0.0011 18.3 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) Cortex-I_coil PF09304.5 KOO21082.1 - 0.003 17.5 1.5 0.0037 17.2 1.0 1.2 1 0 0 1 1 1 1 Cortexillin I, coiled coil Mer2 PF09074.5 KOO21082.1 - 0.0084 16.0 0.1 0.009 15.9 0.1 1.0 1 0 0 1 1 1 1 Mer2 HSCB_C PF07743.8 KOO21082.1 - 0.036 14.5 5.3 0.074 13.5 2.7 1.9 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain ADC PF06314.6 KOO21082.1 - 0.052 12.8 0.1 0.055 12.7 0.1 1.1 1 0 0 1 1 1 0 Acetoacetate decarboxylase (ADC) DUF1387 PF07139.6 KOO21082.1 - 0.064 12.8 0.3 0.077 12.5 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF4404 PF14357.1 KOO21082.1 - 0.32 11.4 2.5 0.62 10.5 1.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) PALP PF00291.20 KOO21083.1 - 8.4e-53 179.5 1.9 1.1e-52 179.1 0.9 1.4 1 1 1 2 2 2 1 Pyridoxal-phosphate dependent enzyme YjeF_N PF03853.10 KOO21083.1 - 0.026 14.1 0.2 0.093 12.3 0.0 2.0 2 0 0 2 2 2 0 YjeF-related protein N-terminus APH PF01636.18 KOO21084.1 - 8e-08 32.3 0.1 1.4e-07 31.5 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family LCM PF04072.9 KOO21085.1 - 1.2e-18 67.3 0.3 7.5e-13 48.4 0.1 2.2 1 1 1 2 2 2 2 Leucine carboxyl methyltransferase PP2C PF00481.16 KOO21086.1 - 5.4e-28 98.0 0.1 2.1e-27 96.1 0.0 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOO21086.1 - 0.0031 17.2 0.1 0.013 15.1 0.0 1.9 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) Oxidored_FMN PF00724.15 KOO21088.1 - 3.4e-10 39.4 0.0 4.7e-06 25.8 0.0 2.3 2 0 0 2 2 2 2 NADH:flavin oxidoreductase / NADH oxidase family NAD_Gly3P_dh_C PF07479.9 KOO21089.1 - 2.2e-42 144.2 0.3 3.5e-42 143.6 0.2 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.18 KOO21089.1 - 1.6e-38 131.9 0.0 3.4e-38 130.8 0.0 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pro_isomerase PF00160.16 KOO21090.1 - 4.1e-43 147.2 0.0 5.1e-43 146.9 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Trichoplein PF13868.1 KOO21091.1 - 3.1e-66 223.1 122.8 3.1e-66 223.1 85.1 2.2 2 0 0 2 2 2 1 Tumour suppressor, Mitostatin GFP PF01353.17 KOO21091.1 - 0.004 16.5 0.5 0.011 15.1 0.1 2.0 1 1 1 2 2 2 1 Green fluorescent protein DnaJ PF00226.26 KOO21092.1 - 6e-16 57.9 0.0 1.1e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 KOO21092.1 - 6.4e-16 58.0 0.0 1.8e-15 56.5 0.0 1.8 2 0 0 2 2 2 1 DnaJ C terminal domain EF-hand_1 PF00036.27 KOO21093.1 - 9.3e-28 93.3 7.3 2.2e-07 29.6 0.3 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO21093.1 - 4.5e-23 81.1 1.4 1.5e-10 41.0 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO21093.1 - 7.5e-23 78.7 4.9 5.5e-05 22.3 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO21093.1 - 7.9e-21 72.0 0.3 0.0012 18.5 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 KOO21093.1 - 1e-16 60.2 10.5 5.1e-06 25.9 0.3 4.4 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.1 KOO21093.1 - 2.1e-08 33.9 0.1 0.0002 21.1 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 KOO21093.1 - 1.3e-07 31.2 0.3 0.0082 15.8 0.0 3.2 3 0 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO21093.1 - 3.1e-06 27.1 0.0 0.096 12.7 0.0 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO21093.1 - 0.28 10.8 2.0 44 3.8 0.0 3.5 4 0 0 4 4 4 0 EF hand DUF4440 PF14534.1 KOO21093.1 - 0.8 9.9 3.8 6 7.1 0.5 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4440) NHL PF01436.16 KOO21094.1 - 3.6e-44 146.5 7.5 1.9e-08 33.8 0.0 5.5 5 0 0 5 5 5 5 NHL repeat SGL PF08450.7 KOO21094.1 - 2.2e-20 73.1 13.7 0.00011 21.7 0.1 5.2 1 1 4 5 5 5 5 SMP-30/Gluconolaconase/LRE-like region BTB PF00651.26 KOO21094.1 - 1e-19 70.5 0.0 2.3e-19 69.4 0.0 1.6 1 1 1 2 2 2 1 BTB/POZ domain DUF839 PF05787.8 KOO21094.1 - 1e-12 47.7 5.3 0.01 14.7 0.1 4.7 1 1 4 5 5 5 4 Bacterial protein of unknown function (DUF839) Tcp10_C PF07202.8 KOO21094.1 - 0.00045 19.8 0.0 0.4 10.1 0.0 2.6 1 1 1 2 2 2 2 T-complex protein 10 C-terminus IN_DBD_C PF00552.16 KOO21094.1 - 0.0021 17.4 0.1 1.5 8.3 0.0 3.9 4 0 0 4 4 4 1 Integrase DNA binding domain SBBP PF06739.6 KOO21094.1 - 0.011 15.5 5.0 12 5.7 0.0 4.9 5 0 0 5 5 5 0 Beta-propeller repeat Phytase-like PF13449.1 KOO21094.1 - 0.016 14.4 0.1 7.7 5.6 0.0 2.9 1 1 0 2 2 2 0 Esterase-like activity of phytase SdiA-regulated PF06977.6 KOO21094.1 - 0.028 13.3 0.1 11 4.9 0.0 2.9 2 2 1 3 3 3 0 SdiA-regulated Ldl_recept_b PF00058.12 KOO21094.1 - 0.041 14.1 2.7 37 4.7 0.0 4.8 5 0 0 5 5 5 0 Low-density lipoprotein receptor repeat class B DUF3342 PF11822.3 KOO21094.1 - 0.059 12.5 0.0 0.15 11.2 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3342) SAP30_Sin3_bdg PF13867.1 KOO21094.1 - 0.19 11.5 0.0 0.34 10.8 0.0 1.3 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 MGDG_synth PF06925.6 KOO21095.1 - 6.1e-15 55.5 0.0 1.2e-14 54.5 0.0 1.5 1 0 0 1 1 1 1 Monogalactosyldiacylglycerol (MGDG) synthase Glyco_tran_28_C PF04101.11 KOO21095.1 - 1.9e-05 24.3 0.0 1.9e-05 24.3 0.0 2.8 3 1 1 4 4 4 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_4 PF13692.1 KOO21095.1 - 0.0002 21.5 0.9 0.00094 19.3 0.1 2.5 2 0 0 2 2 2 1 Glycosyl transferases group 1 DUF4149 PF13664.1 KOO21095.1 - 0.42 10.6 3.5 0.28 11.2 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4149) SLD3 PF08639.5 KOO21095.1 - 6.5 5.2 10.3 0.041 12.5 0.5 1.9 2 0 0 2 2 2 0 DNA replication regulator SLD3 ARL2_Bind_BART PF11527.3 KOO21096.1 - 0.015 15.0 0.2 0.095 12.4 0.1 2.0 1 1 0 1 1 1 0 The ARF-like 2 binding protein BART SAP PF02037.22 KOO21096.1 - 0.098 12.1 0.1 0.65 9.5 0.0 2.1 2 0 0 2 2 2 0 SAP domain Ank PF00023.25 KOO21097.1 - 1.6e-39 131.7 3.4 5e-08 32.3 0.0 6.2 6 0 0 6 6 6 5 Ankyrin repeat Ank_2 PF12796.2 KOO21097.1 - 2.9e-38 130.0 0.5 2.6e-15 56.5 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO21097.1 - 6e-30 102.6 2.5 1.6e-07 31.2 0.1 5.9 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO21097.1 - 3.7e-25 85.4 2.9 4.6e-05 23.2 0.0 6.7 7 0 0 7 7 7 5 Ankyrin repeat Ank_4 PF13637.1 KOO21097.1 - 3.5e-24 84.7 0.7 2.7e-08 34.0 0.0 5.0 2 1 4 6 6 6 5 Ankyrin repeats (many copies) RRM_1 PF00076.17 KOO21098.1 - 9.3e-24 82.8 0.0 2.3e-07 30.3 0.0 5.5 5 1 1 6 6 6 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO21098.1 - 1.4e-18 66.6 0.0 3.5e-07 30.0 0.0 4.4 3 1 1 4 4 4 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO21098.1 - 1.5e-05 24.7 0.0 0.02 14.7 0.0 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YqeY PF09424.5 KOO21098.1 - 0.088 12.6 0.1 0.24 11.2 0.0 1.7 2 0 0 2 2 2 0 Yqey-like protein Rabaptin PF03528.10 KOO21098.1 - 0.3 10.9 5.1 0.14 12.1 0.4 2.5 2 1 1 3 3 3 0 Rabaptin Ion_trans PF00520.26 KOO21099.1 - 0.00012 21.3 1.0 0.00021 20.5 0.7 1.4 1 0 0 1 1 1 1 Ion transport protein T2SF PF00482.18 KOO21101.1 - 0.63 9.9 3.2 0.81 9.6 0.7 2.3 2 1 0 2 2 2 0 Type II secretion system (T2SS), protein F DUF2475 PF10629.4 KOO21102.1 - 0.0022 18.2 2.8 0.47 10.7 0.1 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF2475) DUF4540 PF15073.1 KOO21102.1 - 0.02 15.4 1.2 0.54 10.8 0.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4540) Mito_carr PF00153.22 KOO21103.1 - 6.3e-36 121.9 0.9 3.4e-16 58.7 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein MFS_1 PF07690.11 KOO21104.1 - 5.6e-28 97.6 51.6 2e-20 72.8 15.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Methyltransf_4 PF02390.12 KOO21104.1 - 2.8e-15 55.9 0.0 4.5e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Sugar_tr PF00083.19 KOO21104.1 - 4.1e-06 25.6 23.5 0.00011 20.9 4.2 2.4 1 1 0 2 2 2 2 Sugar (and other) transporter zf-TRM13_CCCH PF11722.3 KOO21104.1 - 0.013 14.8 0.3 0.02 14.2 0.2 1.3 1 0 0 1 1 1 0 CCCH zinc finger in TRM13 protein Methyltransf_31 PF13847.1 KOO21104.1 - 0.22 11.0 0.0 0.41 10.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Sulfotransfer_3 PF13469.1 KOO21105.1 - 0.018 15.9 0.1 0.022 15.7 0.1 1.2 1 0 0 1 1 1 0 Sulfotransferase family LCE PF14672.1 KOO21105.1 - 0.36 11.3 4.2 0.78 10.2 2.9 1.5 1 0 0 1 1 1 0 Late cornified envelope BNR_2 PF13088.1 KOO21107.1 - 3.3e-52 177.4 1.2 4.2e-52 177.1 0.8 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 KOO21107.1 - 0.0009 18.7 1.2 1.4 9.0 1.2 3.0 2 0 0 2 2 2 2 BNR/Asp-box repeat AAA PF00004.24 KOO21109.1 - 2.6e-54 182.9 0.1 3.9e-38 130.6 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOO21109.1 - 6e-10 39.3 1.7 0.0032 17.6 0.2 4.3 2 2 0 2 2 2 2 AAA domain TIP49 PF06068.8 KOO21109.1 - 1e-09 37.6 0.1 0.00092 18.0 0.0 2.2 2 0 0 2 2 2 2 TIP49 C-terminus CDC48_N PF02359.13 KOO21109.1 - 1.3e-09 37.8 0.0 3.6e-09 36.4 0.0 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_5 PF07728.9 KOO21109.1 - 5.1e-09 35.9 0.3 3.2e-05 23.6 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 KOO21109.1 - 2.3e-07 31.6 0.1 0.02 15.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.9 KOO21109.1 - 2.6e-07 30.7 1.2 4.6e-05 23.3 0.4 2.9 2 2 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.1 KOO21109.1 - 4.2e-07 29.9 0.0 0.024 14.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 KOO21109.1 - 8.2e-07 29.1 0.4 0.034 14.1 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain AAA_19 PF13245.1 KOO21109.1 - 2.8e-06 26.9 2.6 0.017 14.8 0.0 3.4 2 1 0 2 2 2 2 Part of AAA domain AAA_18 PF13238.1 KOO21109.1 - 5.5e-06 26.7 0.2 0.026 14.8 0.0 2.7 3 0 0 3 3 2 2 AAA domain Mg_chelatase PF01078.16 KOO21109.1 - 6e-06 25.5 0.5 0.0046 16.1 0.1 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RuvB_N PF05496.7 KOO21109.1 - 1e-05 24.7 0.1 0.025 13.6 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.12 KOO21109.1 - 2.9e-05 23.5 0.1 0.068 12.5 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_33 PF13671.1 KOO21109.1 - 6.8e-05 22.7 0.0 0.52 10.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.21 KOO21109.1 - 6.9e-05 22.3 0.1 0.41 10.1 0.0 2.7 2 0 0 2 2 2 2 Sigma-54 interaction domain DEAD PF00270.24 KOO21109.1 - 0.00016 21.1 2.6 4.2 6.8 0.0 4.3 2 2 1 4 4 4 0 DEAD/DEAH box helicase AAA_24 PF13479.1 KOO21109.1 - 0.00056 19.5 0.6 0.052 13.1 0.1 2.4 2 0 0 2 2 2 1 AAA domain UPF0079 PF02367.12 KOO21109.1 - 0.00057 19.5 0.5 1.1 8.8 0.0 2.6 2 0 0 2 2 2 2 Uncharacterised P-loop hydrolase UPF0079 PhoH PF02562.11 KOO21109.1 - 0.00068 18.9 0.3 1 8.5 0.0 2.7 2 0 0 2 2 2 2 PhoH-like protein Arch_ATPase PF01637.13 KOO21109.1 - 0.00068 19.4 5.5 11 5.6 0.1 4.2 3 1 1 4 4 4 0 Archaeal ATPase KaiC PF06745.8 KOO21109.1 - 0.00085 18.4 1.6 0.024 13.7 0.1 3.2 2 1 0 3 3 3 1 KaiC ABC_tran PF00005.22 KOO21109.1 - 0.00094 19.4 0.3 0.05 13.8 0.1 2.6 2 0 0 2 2 2 1 ABC transporter RNA_helicase PF00910.17 KOO21109.1 - 0.00099 19.2 0.0 0.13 12.4 0.0 2.6 2 0 0 2 2 2 1 RNA helicase NB-ARC PF00931.17 KOO21109.1 - 0.0012 17.7 0.2 0.82 8.4 0.1 3.6 3 0 0 3 3 3 1 NB-ARC domain AAA_28 PF13521.1 KOO21109.1 - 0.0017 18.3 0.1 1.7 8.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.6 KOO21109.1 - 0.0026 17.3 0.0 0.18 11.3 0.0 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 KOO21109.1 - 0.0036 16.7 5.2 0.43 9.9 0.0 3.7 2 2 2 4 4 4 1 AAA domain Zeta_toxin PF06414.7 KOO21109.1 - 0.0043 16.1 0.2 1.5 7.8 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin NACHT PF05729.7 KOO21109.1 - 0.0047 16.5 5.0 0.47 10.0 0.1 3.4 4 0 0 4 4 3 1 NACHT domain CDC48_2 PF02933.12 KOO21109.1 - 0.0052 16.4 0.0 0.1 12.2 0.0 2.7 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 ResIII PF04851.10 KOO21109.1 - 0.0069 16.2 0.0 1.6 8.4 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Sigma54_activ_2 PF14532.1 KOO21109.1 - 0.011 15.7 0.4 6.9 6.7 0.2 3.1 2 1 0 2 2 2 0 Sigma-54 interaction domain T2SE PF00437.15 KOO21109.1 - 0.012 14.5 0.0 1.8 7.4 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein Parvo_NS1 PF01057.12 KOO21109.1 - 0.021 13.6 0.0 0.57 8.9 0.0 2.1 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AFG1_ATPase PF03969.11 KOO21109.1 - 0.028 13.2 0.0 5.5 5.6 0.0 2.4 2 0 0 2 2 2 0 AFG1-like ATPase DUF2075 PF09848.4 KOO21109.1 - 0.033 13.1 0.6 0.52 9.2 0.0 2.6 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2075) IPT PF01745.11 KOO21109.1 - 0.04 13.0 0.2 1.7 7.7 0.0 2.9 3 0 0 3 3 3 0 Isopentenyl transferase AAA_11 PF13086.1 KOO21109.1 - 0.05 13.1 0.0 1.2 8.6 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_23 PF13476.1 KOO21109.1 - 0.067 13.5 0.3 0.82 9.9 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.1 KOO21109.1 - 0.089 12.3 0.6 4.3 6.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain Myco_arth_vir_N PF09610.5 KOO21109.1 - 0.2 11.6 2.4 0.52 10.3 1.7 1.7 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) HIG_1_N PF04588.8 KOO21110.1 - 0.024 14.3 0.6 0.024 14.3 0.4 2.0 2 0 0 2 2 2 0 Hypoxia induced protein conserved region Gemin6 PF06372.7 KOO21111.1 - 0.15 11.3 0.0 1.8 7.8 0.0 2.0 1 1 1 2 2 2 0 Gemin6 protein Orbi_VP6 PF01516.11 KOO21114.1 - 0.92 8.5 4.3 0.14 11.2 0.4 1.5 2 0 0 2 2 2 0 Orbivirus helicase VP6 L_biotic_typeA PF04604.8 KOO21115.1 - 0.23 11.1 0.0 0.54 9.9 0.0 1.6 1 0 0 1 1 1 0 Type-A lantibiotic AA_permease_2 PF13520.1 KOO21116.1 - 1e-36 126.4 19.1 1.4e-36 125.9 13.3 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KOO21116.1 - 1e-26 93.3 15.2 4.4e-26 91.2 10.5 1.7 1 1 0 1 1 1 1 Amino acid permease PEMT PF04191.8 KOO21117.1 - 4e-11 42.9 0.8 5.7e-11 42.4 0.5 1.3 1 1 0 1 1 1 1 Phospholipid methyltransferase ICMT PF04140.9 KOO21117.1 - 7.7e-05 22.8 0.2 0.00013 22.0 0.1 1.3 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF1295 PF06966.7 KOO21117.1 - 0.042 13.1 0.1 0.054 12.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) PH PF00169.24 KOO21118.1 - 4.7e-09 36.3 0.0 6.6e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 KOO21118.1 - 0.00011 22.3 0.9 0.0093 16.2 0.6 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.1 KOO21118.1 - 0.00033 20.6 0.8 0.012 15.6 0.1 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain EF-hand_7 PF13499.1 KOO21119.1 - 1.3e-19 70.0 0.5 2.1e-09 37.3 0.1 3.5 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO21119.1 - 8e-15 52.9 7.7 0.00053 19.0 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO21119.1 - 8.5e-15 53.2 3.4 0.0021 17.7 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO21119.1 - 4.4e-12 44.7 6.1 0.00021 20.5 0.0 4.3 4 0 0 4 4 4 3 EF hand SPARC_Ca_bdg PF10591.4 KOO21119.1 - 2.1e-11 43.8 0.5 0.0011 18.9 0.1 3.3 1 1 2 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.1 KOO21119.1 - 2.8e-10 39.6 3.3 0.0015 18.0 0.1 4.4 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_10 PF14788.1 KOO21119.1 - 0.00032 20.2 0.5 5.8 6.6 0.0 3.9 4 0 0 4 4 4 1 EF hand DUF4419 PF14388.1 KOO21119.1 - 0.046 12.9 0.1 0.091 11.9 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4419) DUF501 PF04417.7 KOO21119.1 - 0.053 13.3 0.1 0.18 11.6 0.0 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF501) EF-hand_9 PF14658.1 KOO21119.1 - 0.07 13.0 0.0 0.92 9.4 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain MCLC PF05934.6 KOO21119.1 - 0.17 10.1 1.0 0.23 9.7 0.7 1.1 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) Gluconate_2-dh3 PF13618.1 KOO21119.1 - 0.19 11.8 8.2 3.2 7.9 0.3 2.4 1 1 0 2 2 2 0 Gluconate 2-dehydrogenase subunit 3 RR_TM4-6 PF06459.7 KOO21119.1 - 0.33 10.8 5.2 0.46 10.3 3.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1007 PF06226.8 KOO21119.1 - 1.3 8.6 5.6 25 4.5 0.1 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1007) FKBP_N PF01346.13 KOO21119.1 - 1.5 8.8 15.0 0.37 10.8 1.9 3.2 1 1 2 3 3 3 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Arm PF00514.18 KOO21120.1 - 0.0011 18.7 16.3 0.31 10.9 0.1 6.0 5 2 0 5 5 5 3 Armadillo/beta-catenin-like repeat HEAT PF02985.17 KOO21120.1 - 0.0018 18.1 5.0 0.044 13.8 0.1 4.3 4 0 0 4 4 4 1 HEAT repeat Trm56 PF01994.11 KOO21121.1 - 0.079 12.7 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 tRNA ribose 2'-O-methyltransferase, aTrm56 EF-hand_1 PF00036.27 KOO21122.1 - 5.2e-13 47.2 0.0 1.8e-05 23.7 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO21122.1 - 5.1e-12 45.7 0.0 7.9e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO21122.1 - 1.1e-10 40.9 0.0 4.1e-09 35.9 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO21122.1 - 1.2e-08 33.8 0.1 0.0017 17.5 0.0 2.8 2 1 1 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO21122.1 - 2.3e-08 33.2 0.0 0.0082 15.9 0.0 2.7 2 1 1 3 3 3 2 EF-hand domain EF-hand_9 PF14658.1 KOO21122.1 - 7.3e-05 22.6 0.0 0.00013 21.8 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.2 KOO21122.1 - 0.013 15.2 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand GRP PF07172.6 KOO21122.1 - 0.066 13.7 6.4 0.099 13.1 4.5 1.3 1 0 0 1 1 1 0 Glycine rich protein family SPARC_Ca_bdg PF10591.4 KOO21122.1 - 0.089 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Arm PF00514.18 KOO21123.1 - 0.0026 17.5 1.4 0.3 10.9 0.2 3.4 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat PRKCSH PF07915.8 KOO21124.1 - 3.3e-08 34.2 2.6 0.003 18.3 0.2 2.8 2 0 0 2 2 2 2 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.1 KOO21124.1 - 0.0028 17.1 0.1 0.009 15.4 0.0 1.8 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein Arm PF00514.18 KOO21125.1 - 1.4e-10 40.5 4.7 1.3e-06 27.9 0.2 4.0 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat EF-hand_7 PF13499.1 KOO21125.1 - 8.2e-08 32.2 0.1 2e-07 31.0 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO21125.1 - 8.5e-08 30.9 0.1 0.0013 17.8 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO21125.1 - 1.9e-05 23.7 0.0 0.004 16.4 0.0 2.6 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO21125.1 - 0.00017 21.2 0.2 0.041 13.7 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.1 KOO21125.1 - 0.0011 18.4 0.7 0.45 10.1 0.0 2.5 1 1 1 2 2 2 2 EF-hand domain pair EAP30 PF04157.11 KOO21125.1 - 0.025 13.7 0.0 0.067 12.3 0.0 1.6 1 1 0 1 1 1 0 EAP30/Vps36 family SPARC_Ca_bdg PF10591.4 KOO21125.1 - 0.027 14.4 0.4 0.048 13.6 0.3 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region SMP_2 PF10144.4 KOO21125.1 - 0.068 12.2 0.6 0.1 11.6 0.4 1.2 1 0 0 1 1 1 0 Bacterial virulence factor haemolysin Imm28 PF15574.1 KOO21125.1 - 0.075 12.6 0.0 0.19 11.2 0.0 1.7 1 0 0 1 1 1 0 Immunity protein 28 EF-hand_1 PF00036.27 KOO21127.1 - 1.8e-21 73.7 3.1 2.1e-06 26.6 0.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO21127.1 - 1e-20 73.6 3.8 3.4e-10 39.8 0.7 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO21127.1 - 1.5e-18 64.9 1.8 8.9e-05 22.0 0.0 4.9 4 0 0 4 4 4 4 EF-hand domain TPR_12 PF13424.1 KOO21127.1 - 6.2e-14 51.6 5.6 5.5e-06 26.2 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat EF-hand_5 PF13202.1 KOO21127.1 - 8.6e-13 46.9 2.0 6.1e-05 22.1 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO21127.1 - 2.1e-12 46.4 3.6 2.1e-07 30.4 0.0 3.4 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO21127.1 - 3.5e-08 33.4 0.2 0.0026 17.7 0.0 2.7 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region AAA_22 PF13401.1 KOO21127.1 - 6.3e-07 29.5 0.0 2.1e-06 27.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain EF-hand_10 PF14788.1 KOO21127.1 - 6.7e-07 28.8 5.0 0.00047 19.7 0.3 3.1 3 0 0 3 3 3 2 EF hand NACHT PF05729.7 KOO21127.1 - 0.00013 21.6 0.0 0.00032 20.3 0.0 1.7 1 0 0 1 1 1 1 NACHT domain DUF4062 PF13271.1 KOO21127.1 - 0.00049 20.0 0.0 0.004 17.1 0.0 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4062) AAA_16 PF13191.1 KOO21127.1 - 0.0057 16.6 0.0 0.041 13.8 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain TPR_8 PF13181.1 KOO21127.1 - 0.035 13.8 0.9 24 5.0 0.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Proteasome PF00227.21 KOO21128.1 - 9.6e-20 70.6 0.6 2.4e-19 69.3 0.4 1.5 1 1 0 1 1 1 1 Proteasome subunit T2SK PF03934.8 KOO21130.1 - 0.053 12.6 0.0 0.069 12.2 0.0 1.1 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein K Myb_DNA-binding PF00249.26 KOO21131.1 - 4.2e-15 55.5 0.2 3.3e-12 46.2 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO21131.1 - 0.00054 19.9 0.0 0.0011 18.9 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain RuvA_C PF07499.8 KOO21131.1 - 0.023 14.8 0.0 0.045 13.9 0.0 1.4 1 0 0 1 1 1 0 RuvA, C-terminal domain Bacteriocin_IIc PF10439.4 KOO21131.1 - 0.15 12.1 0.0 0.15 12.1 0.0 1.8 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide Trypsin_2 PF13365.1 KOO21132.1 - 4.9e-21 74.9 0.2 1e-20 73.9 0.2 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.21 KOO21132.1 - 3.8e-16 59.3 0.1 8.5e-16 58.2 0.0 1.5 2 0 0 2 2 2 1 Trypsin PDZ_2 PF13180.1 KOO21132.1 - 3.1e-12 46.1 0.1 7e-12 45.0 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.19 KOO21132.1 - 0.021 14.9 0.3 0.87 9.8 0.2 2.8 1 1 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) Peptidase_S29 PF02907.10 KOO21132.1 - 0.024 14.1 0.1 0.072 12.6 0.0 1.8 2 0 0 2 2 2 0 Hepatitis C virus NS3 protease Peptidase_S46 PF10459.4 KOO21132.1 - 0.028 12.8 1.7 0.72 8.2 0.2 2.3 2 1 0 2 2 2 0 Peptidase S46 Peptidase_S32 PF05579.8 KOO21132.1 - 0.031 13.2 1.4 0.81 8.6 0.0 2.2 2 0 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 Mito_carr PF00153.22 KOO21133.1 - 1.7e-52 175.0 5.2 2.6e-19 68.7 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.1 KOO21133.1 - 2.6e-21 75.5 2.4 5.5e-12 45.6 0.2 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO21133.1 - 5.4e-21 72.2 2.7 1.8e-06 26.8 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_5 PF13202.1 KOO21133.1 - 5.2e-19 66.6 3.4 1e-05 24.6 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 KOO21133.1 - 1.8e-17 62.7 3.0 2.6e-10 39.7 0.1 3.4 2 1 2 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO21133.1 - 3e-15 54.6 6.3 1.5e-05 24.4 0.1 4.5 4 0 0 4 4 4 3 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO21133.1 - 0.0012 18.8 0.0 0.0098 15.9 0.0 2.0 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO21133.1 - 0.018 14.7 0.1 0.42 10.3 0.0 2.3 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO21133.1 - 0.034 14.0 0.0 0.069 13.0 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain zf-C2H2 PF00096.21 KOO21134.1 - 0.069 13.5 0.9 0.11 12.8 0.7 1.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-met PF12874.2 KOO21134.1 - 0.22 11.8 2.3 0.37 11.0 1.6 1.3 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 KOO21134.1 - 0.26 11.4 1.4 0.42 10.8 0.9 1.3 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.1 KOO21134.1 - 0.75 10.1 2.4 1.2 9.5 1.7 1.3 1 0 0 1 1 1 0 C2H2-type zinc-finger domain MIF4G PF02854.14 KOO21135.1 - 1.7e-08 34.1 0.0 2.6e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 MIF4G domain YscO PF07321.7 KOO21135.1 - 0.039 13.7 0.5 0.072 12.9 0.3 1.4 1 0 0 1 1 1 0 Type III secretion protein YscO EF-hand_6 PF13405.1 KOO21136.1 - 0.0036 17.0 0.0 0.033 14.0 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 KOO21136.1 - 0.0038 16.4 0.0 0.021 14.0 0.0 2.3 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO21136.1 - 0.0054 16.8 0.1 0.017 15.2 0.1 1.9 1 1 0 1 1 1 1 EF-hand domain pair TM1506 PF08973.5 KOO21136.1 - 0.043 13.3 0.0 0.15 11.5 0.0 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1893) Filamin PF00630.14 KOO21137.1 - 6.1e-11 42.7 0.0 0.00045 20.7 0.0 3.6 4 0 0 4 4 4 2 Filamin/ABP280 repeat PapC_N PF13954.1 KOO21137.1 - 0.048 13.2 0.0 3.4 7.2 0.0 2.7 3 0 0 3 3 3 0 PapC N-terminal domain Med3 PF11593.3 KOO21137.1 - 6.8 5.8 15.8 11 5.1 11.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF563 PF04577.9 KOO21138.1 - 1.5e-17 64.2 0.3 2.8e-17 63.3 0.2 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF563) Glycos_transf_1 PF00534.15 KOO21139.1 - 0.016 14.6 0.0 0.026 13.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 KOO21139.1 - 0.026 14.6 0.0 0.042 13.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 TRAP_alpha PF03896.11 KOO21140.1 - 4e-07 29.3 0.0 5e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Mg_trans_NIPA PF05653.9 KOO21141.1 - 1.1e-113 379.2 15.7 1.3e-113 378.9 10.9 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EmrE PF13536.1 KOO21141.1 - 1.8e-06 28.1 5.3 1.8e-06 28.1 3.7 3.2 2 1 1 3 3 3 2 Multidrug resistance efflux transporter EamA PF00892.15 KOO21141.1 - 0.00067 19.7 7.6 0.00067 19.7 5.3 3.9 2 2 2 4 4 4 1 EamA-like transporter family Rif1_N PF12231.3 KOO21142.1 - 0.0019 17.2 0.0 0.0034 16.3 0.0 1.4 2 0 0 2 2 2 1 Rap1-interacting factor 1 N terminal Vfa1 PF08432.5 KOO21142.1 - 4.9 7.1 6.7 16 5.4 2.9 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Pkinase PF00069.20 KOO21144.1 - 4.8e-59 199.6 0.0 9e-59 198.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21144.1 - 4e-36 124.4 0.0 6.5e-36 123.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO21144.1 - 1.6e-06 27.2 0.0 6.4e-05 22.0 0.0 2.3 2 0 0 2 2 2 1 Kinase-like DUF1471 PF07338.8 KOO21144.1 - 0.1 12.2 0.0 0.1 12.2 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1471) OB_NTP_bind PF07717.11 KOO21145.1 - 3.9e-31 107.2 0.0 7e-31 106.4 0.0 1.4 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 KOO21145.1 - 4.8e-26 90.7 0.0 1e-25 89.6 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) DEAD PF00270.24 KOO21145.1 - 1.2e-06 28.1 0.2 4.3e-06 26.3 0.2 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase S1 PF00575.18 KOO21145.1 - 1.5e-06 28.1 0.0 3e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 S1 RNA binding domain AAA_22 PF13401.1 KOO21145.1 - 3.8e-06 27.0 0.1 8.8e-06 25.8 0.1 1.6 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 KOO21145.1 - 0.0008 18.3 0.1 0.0016 17.3 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.1 KOO21145.1 - 0.0055 16.4 0.0 0.015 15.0 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain Sigma54_activ_2 PF14532.1 KOO21145.1 - 0.006 16.6 0.2 0.049 13.6 0.0 2.5 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_14 PF13173.1 KOO21145.1 - 0.028 14.3 0.1 0.26 11.1 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.1 KOO21145.1 - 0.03 13.9 0.6 0.067 12.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain Flavi_DEAD PF07652.9 KOO21145.1 - 0.033 13.9 0.1 0.064 13.0 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain ABC_tran PF00005.22 KOO21145.1 - 0.041 14.1 0.4 0.72 10.1 0.1 2.6 1 1 0 2 2 2 0 ABC transporter PhoH PF02562.11 KOO21145.1 - 0.048 12.8 0.2 0.12 11.5 0.1 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.1 KOO21145.1 - 0.081 12.3 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.4 KOO21145.1 - 0.083 11.8 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 NB-ARC PF00931.17 KOO21145.1 - 0.093 11.5 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain SRP54 PF00448.17 KOO21145.1 - 0.14 11.6 0.1 0.25 10.7 0.1 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain UvrD-helicase PF00580.16 KOO21145.1 - 0.14 11.3 0.1 0.26 10.5 0.0 1.4 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Myosin_head PF00063.16 KOO21145.1 - 0.22 9.5 0.0 0.3 9.0 0.0 1.1 1 0 0 1 1 1 0 Myosin head (motor domain) SATase_N PF06426.9 KOO21146.1 - 5.5e-13 49.0 0.5 5.5e-12 45.8 0.1 2.4 2 1 0 2 2 2 1 Serine acetyltransferase, N-terminal Hexapep PF00132.19 KOO21146.1 - 9.6e-11 40.6 12.1 6.6e-06 25.4 1.5 3.5 3 0 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 KOO21146.1 - 1.6e-07 30.7 8.8 0.002 17.6 2.7 3.4 3 0 0 3 3 3 3 Hexapeptide repeat of succinyl-transferase DBI_PRT PF02277.12 KOO21147.1 - 2.6e-63 214.0 8.5 3.3e-63 213.7 5.9 1.1 1 0 0 1 1 1 1 Phosphoribosyltransferase TTL PF03133.10 KOO21148.1 - 7.5e-25 87.4 0.0 1.1e-24 86.9 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family EF-hand_1 PF00036.27 KOO21149.1 - 6e-34 112.7 11.0 4.5e-09 34.9 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO21149.1 - 5e-28 97.0 9.4 1.4e-15 57.1 0.3 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO21149.1 - 4.3e-26 88.4 10.1 4.6e-09 35.3 0.0 4.9 4 2 1 5 5 5 4 EF-hand domain EF-hand_8 PF13833.1 KOO21149.1 - 1.2e-25 88.8 11.3 2.8e-12 46.0 0.2 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO21149.1 - 1.1e-23 81.4 9.1 3.4e-06 26.1 0.2 4.7 4 1 1 5 5 5 4 EF hand EF-hand_9 PF14658.1 KOO21149.1 - 6.2e-13 48.4 0.1 4.4e-07 29.7 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 KOO21149.1 - 2e-06 27.4 4.0 0.15 11.8 0.6 3.6 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO21149.1 - 0.0014 18.6 0.1 1.4 8.9 0.0 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region LETM1 PF07766.8 KOO21149.1 - 0.011 14.8 0.2 0.014 14.4 0.1 1.3 1 0 0 1 1 1 0 LETM1-like protein Caleosin PF05042.8 KOO21149.1 - 0.012 15.1 0.1 5.3 6.5 0.0 2.5 2 1 0 2 2 2 0 Caleosin related protein Toprim_2 PF13155.1 KOO21149.1 - 0.015 15.6 1.8 5 7.5 0.0 2.4 1 1 1 2 2 2 0 Toprim-like Acetyltransf_11 PF13720.1 KOO21149.1 - 0.038 14.2 0.3 1.9 8.7 0.0 2.4 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 OST-HTH PF12872.2 KOO21149.1 - 0.046 13.5 0.0 15 5.5 0.0 3.1 3 1 1 4 4 4 0 OST-HTH/LOTUS domain PMBR PF09373.5 KOO21149.1 - 0.086 12.8 0.2 18 5.4 0.0 4.4 6 0 0 6 6 6 0 Pseudomurein-binding repeat TyeA PF09059.5 KOO21149.1 - 0.093 12.6 0.1 0.41 10.5 0.0 1.9 2 0 0 2 2 2 0 TyeA DUF21 PF01595.15 KOO21149.1 - 0.098 11.9 0.2 0.66 9.2 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF21 DUF3008 PF11450.3 KOO21149.1 - 0.099 12.7 0.2 0.099 12.7 0.1 3.3 4 0 0 4 4 4 0 Protein of unknwon function (DUF3008) UPF0154 PF03672.8 KOO21149.1 - 0.1 12.2 0.5 9.6 5.9 0.0 3.3 4 0 0 4 4 4 0 Uncharacterised protein family (UPF0154) DUF4373 PF14297.1 KOO21149.1 - 0.24 11.7 1.8 53 4.1 0.1 3.3 1 1 3 4 4 4 0 Domain of unknown function (DUF4373) EF-hand_10 PF14788.1 KOO21149.1 - 0.5 10.0 3.1 8.7 6.1 0.2 2.9 2 1 1 3 3 3 0 EF hand Endonuc-dimeris PF09124.5 KOO21149.1 - 0.7 9.5 3.7 12 5.5 0.0 2.9 3 0 0 3 3 3 0 T4 recombination endonuclease VII, dimerisation DUF2757 PF10955.3 KOO21149.1 - 1.6 9.0 3.3 31 4.8 0.2 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2757) RRM_6 PF14259.1 KOO21150.1 - 4.7e-39 132.2 0.0 5.2e-11 42.3 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOO21150.1 - 1.6e-21 75.6 0.0 5.3e-07 29.1 0.0 4.5 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO21150.1 - 1.3e-05 24.9 0.0 0.42 10.5 0.0 4.4 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SBDS PF01172.13 KOO21151.1 - 1.3e-25 88.9 0.5 2.2e-25 88.2 0.4 1.4 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.5 KOO21151.1 - 3e-25 88.3 0.2 6.2e-25 87.3 0.1 1.5 1 0 0 1 1 1 1 SBDS protein C-terminal domain Sel1 PF08238.7 KOO21151.1 - 6.5e-06 26.6 0.1 1.5e-05 25.4 0.1 1.7 1 0 0 1 1 1 1 Sel1 repeat DUF4170 PF13773.1 KOO21151.1 - 0.087 12.7 0.4 10 6.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4170) DUF3416 PF11896.3 KOO21151.1 - 1.1 9.2 5.8 2.1 8.2 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3416) DAO PF01266.19 KOO21152.1 - 8.4e-34 117.0 8.8 2e-33 115.7 6.1 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 KOO21152.1 - 3.4e-07 29.4 7.2 9.9e-06 24.6 5.0 2.3 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 KOO21152.1 - 4.9e-07 29.6 0.0 1.9e-06 27.7 0.0 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 KOO21152.1 - 1e-05 25.5 0.1 1.8e-05 24.7 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOO21152.1 - 1.4e-05 25.3 0.0 7.3e-05 23.0 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 KOO21152.1 - 3.4e-05 23.0 0.1 6.5e-05 22.1 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 KOO21152.1 - 0.00017 20.7 0.1 0.00073 18.6 0.0 1.9 2 0 0 2 2 2 1 Thi4 family FAD_oxidored PF12831.2 KOO21152.1 - 0.00038 19.6 0.4 0.0032 16.6 0.2 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 KOO21152.1 - 0.00064 19.8 0.0 0.00099 19.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 KOO21152.1 - 0.0012 17.8 0.1 0.003 16.5 0.0 1.6 1 1 0 1 1 1 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.16 KOO21152.1 - 0.012 15.2 0.1 0.053 13.0 0.0 2.1 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.9 KOO21152.1 - 0.012 14.0 0.1 0.018 13.4 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein TrkA_N PF02254.13 KOO21152.1 - 0.012 15.5 0.0 0.028 14.4 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.13 KOO21152.1 - 0.015 14.9 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.17 KOO21152.1 - 0.021 13.6 0.0 0.033 13.0 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A AdoHcyase_NAD PF00670.16 KOO21152.1 - 0.021 14.6 0.1 0.039 13.7 0.1 1.3 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain XdhC_C PF13478.1 KOO21152.1 - 0.032 14.5 0.0 0.061 13.6 0.0 1.5 1 0 0 1 1 1 0 XdhC Rossmann domain ApbA PF02558.11 KOO21152.1 - 0.033 13.6 0.0 0.073 12.5 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.9 KOO21152.1 - 0.096 12.0 0.1 0.17 11.2 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ThiF PF00899.16 KOO21152.1 - 0.13 12.0 0.5 0.31 10.8 0.4 1.6 1 0 0 1 1 1 0 ThiF family FKBP_C PF00254.23 KOO21154.1 - 4.8e-33 113.0 0.0 6.1e-33 112.7 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Sod_Cu PF00080.15 KOO21155.1 - 1.6e-41 141.7 1.8 5.1e-22 78.5 0.2 2.1 2 0 0 2 2 2 2 Copper/zinc superoxide dismutase (SODC) Amidoligase_2 PF12224.3 KOO21156.1 - 2.2e-08 34.0 0.3 5e-05 23.0 0.0 2.3 2 0 0 2 2 2 2 Putative amidoligase enzyme Ala_racemase_N PF01168.15 KOO21157.1 - 1.9e-15 57.0 0.0 2.3e-15 56.7 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain D-ser_dehydrat PF14031.1 KOO21157.1 - 1.7e-06 28.1 0.4 7.9e-06 25.9 0.0 2.3 3 0 0 3 3 3 1 Putative serine dehydratase domain TPR_11 PF13414.1 KOO21158.1 - 3.1e-42 142.0 38.6 1.6e-17 62.9 2.1 5.3 2 2 4 6 6 6 5 TPR repeat TPR_1 PF00515.23 KOO21158.1 - 3.5e-27 92.8 20.0 3.4e-06 26.4 0.2 7.1 7 0 0 7 7 6 5 Tetratricopeptide repeat TPR_2 PF07719.12 KOO21158.1 - 4.4e-23 79.2 32.6 1.1e-05 24.9 0.2 8.4 9 1 1 10 10 7 6 Tetratricopeptide repeat TPR_16 PF13432.1 KOO21158.1 - 1.3e-17 63.9 39.7 3.2e-07 30.8 3.3 7.5 6 1 2 8 8 8 5 Tetratricopeptide repeat TPR_17 PF13431.1 KOO21158.1 - 5.6e-15 54.2 14.6 0.0084 16.2 0.0 8.6 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_19 PF14559.1 KOO21158.1 - 1.5e-13 50.8 22.5 1.8e-05 24.9 0.6 5.9 4 2 1 6 6 5 4 Tetratricopeptide repeat DnaJ PF00226.26 KOO21158.1 - 1.2e-12 47.3 0.5 1.2e-12 47.3 0.4 2.7 3 0 0 3 3 3 1 DnaJ domain TPR_14 PF13428.1 KOO21158.1 - 2.7e-11 43.0 37.8 0.0016 18.8 0.1 9.7 4 2 6 10 10 10 5 Tetratricopeptide repeat Apc3 PF12895.2 KOO21158.1 - 5.3e-11 42.5 8.4 1.2e-05 25.2 1.5 2.7 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 KOO21158.1 - 3e-07 29.7 10.3 0.74 9.7 0.3 7.0 7 1 1 8 8 7 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO21158.1 - 1.3e-06 28.1 24.6 0.00014 21.6 2.2 6.4 4 2 1 6 6 5 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO21158.1 - 2.5e-06 27.3 27.2 0.11 12.4 0.7 5.6 3 2 3 6 6 5 4 Tetratricopeptide repeat TPR_7 PF13176.1 KOO21158.1 - 0.00028 20.4 16.1 0.23 11.3 0.1 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO21158.1 - 0.00068 19.4 10.2 2.3 8.1 0.1 5.1 5 0 0 5 5 5 2 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.1 KOO21158.1 - 0.05 14.0 23.6 14 6.4 0.1 7.9 8 0 0 8 8 7 0 Tetratricopeptide repeat Sulfotransfer_2 PF03567.9 KOO21158.1 - 0.12 12.0 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 Sulfotransferase family DUF217 PF02697.9 KOO21158.1 - 0.54 10.5 1.9 5.7 7.2 0.3 3.0 1 1 0 2 2 2 0 Uncharacterized ACR, COG1753 SHNi-TPR PF10516.4 KOO21158.1 - 7.7 5.8 9.8 20 4.5 0.0 4.2 4 0 0 4 4 4 0 SHNi-TPR MIT PF04212.13 KOO21158.1 - 8.6 6.3 16.2 0.31 10.9 0.9 3.6 4 0 0 4 4 3 0 MIT (microtubule interacting and transport) domain BTAD PF03704.12 KOO21158.1 - 8.7 6.6 42.1 0.53 10.5 4.4 6.2 4 2 1 5 5 5 0 Bacterial transcriptional activator domain EF-hand_1 PF00036.27 KOO21159.1 - 1.1e-25 86.8 9.2 5.9e-06 25.2 0.1 5.3 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.1 KOO21159.1 - 1.4e-23 80.5 9.7 5.5e-06 25.8 0.2 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_7 PF13499.1 KOO21159.1 - 1.8e-18 66.4 6.8 9.2e-10 38.5 0.1 3.7 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO21159.1 - 6.6e-18 63.1 11.6 0.0029 16.8 0.1 5.4 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.1 KOO21159.1 - 4.8e-14 51.6 13.4 4.6e-05 22.9 0.2 5.0 3 2 2 5 5 5 4 EF-hand domain pair EF-hand_4 PF12763.2 KOO21159.1 - 0.54 10.0 3.9 9.6 6.0 0.0 3.7 4 1 1 5 5 5 0 Cytoskeletal-regulatory complex EF hand WW PF00397.21 KOO21160.1 - 2.5e-13 49.6 11.2 5.7e-08 32.4 0.6 2.4 2 0 0 2 2 2 2 WW domain SAP PF02037.22 KOO21160.1 - 0.093 12.2 0.0 0.28 10.7 0.0 1.9 1 0 0 1 1 1 0 SAP domain Bestrophin PF01062.16 KOO21162.1 - 9.9e-23 80.5 0.0 3.4e-22 78.7 0.0 1.8 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Ion_trans_2 PF07885.11 KOO21162.1 - 0.016 14.9 3.9 0.016 14.9 2.7 2.4 2 1 0 2 2 2 0 Ion channel YqjK PF13997.1 KOO21163.1 - 0.3 11.2 1.7 5.2 7.3 0.9 2.5 1 1 1 2 2 2 0 YqjK-like protein Mito_carr PF00153.22 KOO21164.1 - 2.4e-08 33.5 4.3 0.0025 17.4 0.2 3.9 1 1 1 2 2 2 2 Mitochondrial carrier protein TcpQ PF10671.4 KOO21165.1 - 0.7 9.8 4.2 0.32 10.9 0.6 2.1 2 0 0 2 2 2 0 Toxin co-regulated pilus biosynthesis protein Q bZIP_1 PF00170.16 KOO21166.1 - 0.01 15.8 4.4 0.024 14.5 3.0 1.5 1 0 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.10 KOO21166.1 - 0.011 15.5 3.5 0.021 14.6 2.4 1.4 1 0 0 1 1 1 0 Basic region leucine zipper Ion_trans PF00520.26 KOO21167.1 - 6.2e-33 113.7 13.9 8.7e-33 113.2 9.6 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.7 KOO21167.1 - 0.23 9.8 14.3 0.23 9.8 3.9 2.4 2 1 0 2 2 2 0 Polycystin cation channel VirB8 PF04335.8 KOO21169.1 - 1.4 8.4 4.8 2.5 7.6 3.4 1.4 1 0 0 1 1 1 0 VirB8 protein EF-hand_7 PF13499.1 KOO21170.1 - 7.8e-25 86.8 5.4 3.9e-09 36.5 0.8 4.8 4 1 0 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO21170.1 - 3.5e-20 71.3 16.5 5.9e-11 41.8 0.6 5.9 3 3 3 6 6 6 4 EF-hand domain pair EF-hand_1 PF00036.27 KOO21170.1 - 3.8e-20 69.6 14.9 0.00012 21.1 0.0 6.9 7 0 0 7 7 7 4 EF hand EF-hand_6 PF13405.1 KOO21170.1 - 1.7e-17 61.6 15.4 0.0043 16.8 0.6 7.0 7 0 0 7 7 7 4 EF-hand domain EF-hand_5 PF13202.1 KOO21170.1 - 6.1e-11 41.1 15.2 0.0023 17.1 0.0 5.9 7 0 0 7 7 7 4 EF hand TraF_2 PF13729.1 KOO21170.1 - 0.004 16.0 0.4 0.0093 14.7 0.3 1.6 1 0 0 1 1 1 1 F plasmid transfer operon, TraF, protein EF-hand_4 PF12763.2 KOO21170.1 - 0.0099 15.5 2.3 0.11 12.2 0.3 3.4 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand NPV_P10 PF05531.7 KOO21170.1 - 0.017 15.3 3.1 2.1 8.6 0.0 3.6 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.7 KOO21170.1 - 0.029 14.1 2.0 3.2 7.5 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) SPARC_Ca_bdg PF10591.4 KOO21170.1 - 0.037 14.0 1.2 4.3 7.4 0.1 3.6 3 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Flagellin_C PF00700.16 KOO21170.1 - 0.055 13.6 3.1 10 6.3 0.0 3.7 3 0 0 3 3 3 0 Bacterial flagellin C-terminal helical region Rootletin PF15035.1 KOO21170.1 - 0.058 13.3 5.1 0.26 11.2 1.4 2.7 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion IncA PF04156.9 KOO21170.1 - 0.24 10.9 10.6 0.91 9.0 0.9 2.8 3 0 0 3 3 3 0 IncA protein HALZ PF02183.13 KOO21170.1 - 1.6 8.5 5.9 0.45 10.2 0.3 3.0 3 0 0 3 3 3 0 Homeobox associated leucine zipper V_ATPase_I PF01496.14 KOO21170.1 - 1.7 6.3 7.5 0.62 7.8 0.4 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Atg14 PF10186.4 KOO21170.1 - 1.7 7.4 8.8 2.1 7.2 1.1 2.6 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 APG6 PF04111.7 KOO21170.1 - 1.9 7.4 8.8 1.5 7.7 0.2 2.6 2 0 0 2 2 2 0 Autophagy protein Apg6 Prefoldin_2 PF01920.15 KOO21170.1 - 6.3 6.6 11.3 8.9 6.1 0.3 3.4 3 0 0 3 3 3 0 Prefoldin subunit RabGAP-TBC PF00566.13 KOO21171.1 - 1.9e-14 53.6 0.0 2.7e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GAS PF13851.1 KOO21171.1 - 0.65 9.1 10.6 0.94 8.6 3.3 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding TMCO5 PF14992.1 KOO21171.1 - 3.3 6.7 6.9 2.1 7.4 1.9 2.1 2 0 0 2 2 2 0 TMCO5 family B12D PF06522.6 KOO21172.1 - 5.7e-06 25.9 0.0 9.5e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit UQ_con PF00179.21 KOO21173.1 - 7e-45 151.8 0.0 7.7e-45 151.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KOO21173.1 - 1.5e-06 27.9 0.0 1.9e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.8 KOO21173.1 - 0.0037 16.9 0.1 0.0058 16.3 0.1 1.4 1 1 0 1 1 1 1 UEV domain RWD PF05773.17 KOO21173.1 - 0.045 13.6 0.0 0.055 13.3 0.0 1.3 1 0 0 1 1 1 0 RWD domain EDR1 PF14381.1 KOO21174.1 - 8.3e-31 107.1 0.0 1.4e-30 106.3 0.0 1.3 1 0 0 1 1 1 1 Ethylene-responsive protein kinase Le-CTR1 FKBP_C PF00254.23 KOO21175.1 - 4.7e-14 52.1 0.0 6.8e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF2810 PF10928.3 KOO21176.1 - 0.0089 15.7 2.5 19 5.0 0.0 3.3 3 0 0 3 3 3 3 Protein of unknown function (DUF2810) Keratin PF02422.11 KOO21176.1 - 0.93 9.5 14.9 3.2 7.7 0.8 3.6 2 1 2 4 4 4 0 Keratin Methyltransf_18 PF12847.2 KOO21178.1 - 0.0065 17.0 0.0 0.0097 16.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO21178.1 - 0.042 14.1 0.0 0.066 13.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain NodS PF05401.6 KOO21178.1 - 0.046 13.1 0.0 0.059 12.7 0.0 1.1 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_11 PF08241.7 KOO21178.1 - 0.1 13.0 0.0 0.14 12.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain EF-hand_1 PF00036.27 KOO21179.1 - 1.5e-06 27.0 0.0 0.001 18.2 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO21179.1 - 4.1e-05 23.0 0.0 0.0047 16.7 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.1 KOO21179.1 - 5.9e-05 23.1 0.0 0.00019 21.4 0.0 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO21179.1 - 0.001 18.3 0.0 0.0035 16.6 0.0 2.0 2 0 0 2 2 2 1 EF hand Ribosomal_L18p PF00861.17 KOO21179.1 - 0.04 14.1 0.6 0.12 12.5 0.3 1.9 1 1 0 1 1 1 0 Ribosomal L18p/L5e family EF-hand_8 PF13833.1 KOO21179.1 - 0.17 11.5 0.6 8.1 6.1 0.1 2.8 2 1 1 3 3 3 0 EF-hand domain pair RRM_1 PF00076.17 KOO21180.1 - 6.2e-12 44.9 0.0 2.1e-09 36.8 0.0 2.3 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO21180.1 - 3.4e-10 39.7 0.0 1.9e-09 37.3 0.0 2.1 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) UVR PF02151.14 KOO21180.1 - 0.052 13.0 0.2 0.1 12.1 0.1 1.4 1 0 0 1 1 1 0 UvrB/uvrC motif RRM_5 PF13893.1 KOO21180.1 - 0.1 12.4 0.0 0.99 9.3 0.0 2.1 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ubiquitin PF00240.18 KOO21181.1 - 8.7e-05 21.8 0.0 0.00021 20.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.1 KOO21181.1 - 0.0051 17.0 0.0 0.011 15.9 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain CCDC84 PF14968.1 KOO21181.1 - 0.037 13.5 0.3 0.058 12.8 0.2 1.3 1 0 0 1 1 1 0 Coiled coil protein 84 cNMP_binding PF00027.24 KOO21182.1 - 4.8e-23 80.7 0.0 7.8e-12 44.8 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain GcpE PF04551.9 KOO21183.1 - 3.6e-146 486.5 0.0 5.2e-146 486.0 0.0 1.2 1 0 0 1 1 1 1 GcpE protein Sgf11 PF08209.6 KOO21183.1 - 0.15 11.4 0.8 0.73 9.1 0.1 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Tic22 PF04278.7 KOO21184.1 - 1.3e-21 77.0 0.1 1.8e-21 76.6 0.1 1.2 1 0 0 1 1 1 1 Tic22-like family Rad51 PF08423.6 KOO21186.1 - 2.2e-22 79.1 0.0 8.6e-16 57.6 0.0 2.1 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.1 KOO21186.1 - 2.4e-12 46.6 0.0 4.7e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain RecA PF00154.16 KOO21186.1 - 0.002 17.2 0.1 0.23 10.4 0.0 2.1 2 0 0 2 2 2 2 recA bacterial DNA recombination protein KaiC PF06745.8 KOO21186.1 - 0.0023 17.1 0.1 0.0081 15.3 0.0 1.8 2 0 0 2 2 2 1 KaiC DnaB_C PF03796.10 KOO21186.1 - 0.027 13.3 0.1 0.81 8.5 0.0 2.1 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain AAA_22 PF13401.1 KOO21186.1 - 0.029 14.5 0.0 0.058 13.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain Cdd1 PF11731.3 KOO21186.1 - 0.084 12.7 0.0 0.54 10.2 0.0 2.2 2 0 0 2 2 2 0 Pathogenicity locus IstB_IS21 PF01695.12 KOO21186.1 - 0.12 11.8 0.0 5.3 6.4 0.0 2.4 2 1 0 2 2 2 0 IstB-like ATP binding protein AAA_5 PF07728.9 KOO21186.1 - 0.15 11.8 0.1 0.6 9.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Hist_deacetyl PF00850.14 KOO21188.1 - 5.5e-77 259.1 0.0 8e-77 258.5 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain DnaJ PF00226.26 KOO21189.1 - 5.9e-25 86.7 1.3 4.6e-24 83.9 0.1 2.3 2 0 0 2 2 2 1 DnaJ domain DUF1977 PF09320.6 KOO21189.1 - 0.021 15.0 1.6 0.031 14.5 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1977) CRA_rpt PF07046.6 KOO21189.1 - 8.9 6.3 14.0 8.9 6.3 1.9 3.2 2 1 0 2 2 2 0 Cytoplasmic repetitive antigen (CRA) like repeat ABC_tran PF00005.22 KOO21190.1 - 1.1e-26 93.7 0.0 1.6e-26 93.2 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 KOO21190.1 - 7.7e-07 29.3 0.0 0.044 13.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 KOO21190.1 - 1e-05 25.5 0.1 3.1e-05 24.0 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.1 KOO21190.1 - 0.00028 20.3 0.8 0.0084 15.5 0.0 2.5 3 0 0 3 3 3 1 AAA domain DUF258 PF03193.11 KOO21190.1 - 0.00039 19.6 0.0 0.00068 18.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 KOO21190.1 - 0.0037 16.7 0.1 0.012 15.1 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain Adeno_IVa2 PF02456.10 KOO21190.1 - 0.0071 15.0 0.0 0.011 14.4 0.0 1.1 1 0 0 1 1 1 1 Adenovirus IVa2 protein Arch_ATPase PF01637.13 KOO21190.1 - 0.0091 15.7 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 1 Archaeal ATPase SMC_N PF02463.14 KOO21190.1 - 0.011 15.0 0.0 3.1 6.9 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Rad17 PF03215.10 KOO21190.1 - 0.019 13.6 0.1 0.028 13.0 0.0 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 KOO21190.1 - 0.019 15.0 0.1 0.072 13.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.1 KOO21190.1 - 0.035 14.0 0.1 0.21 11.5 0.1 2.1 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_14 PF13173.1 KOO21190.1 - 0.037 13.9 0.0 0.073 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 KOO21190.1 - 0.046 13.9 0.0 0.41 10.8 0.0 2.1 2 0 0 2 2 2 0 RNA helicase AAA_17 PF13207.1 KOO21190.1 - 0.053 14.3 0.2 0.13 13.0 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 KOO21190.1 - 0.24 11.7 0.1 0.47 10.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 KOO21190.1 - 0.28 11.4 0.0 0.45 10.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain Peptidase_S9 PF00326.16 KOO21191.1 - 1.1e-47 162.0 0.0 3.1e-47 160.5 0.0 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 KOO21191.1 - 3.7e-12 46.1 0.3 1.1e-11 44.6 0.1 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family DLH PF01738.13 KOO21191.1 - 2.1e-08 33.7 0.0 3.5e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.2 KOO21191.1 - 0.00034 20.5 6.2 0.00086 19.2 1.7 2.9 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.5 KOO21191.1 - 0.004 17.0 0.0 0.017 15.0 0.0 2.0 2 0 0 2 2 2 1 TAP-like protein Abhydrolase_3 PF07859.8 KOO21191.1 - 0.0047 16.5 0.1 0.017 14.7 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold PAE PF03283.8 KOO21191.1 - 0.018 13.6 0.1 0.028 13.0 0.1 1.2 1 0 0 1 1 1 0 Pectinacetylesterase Abhydrolase_2 PF02230.11 KOO21191.1 - 0.1 12.0 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase PhoPQ_related PF10142.4 KOO21191.1 - 0.13 10.6 0.0 0.2 10.0 0.0 1.2 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein DUF1387 PF07139.6 KOO21192.1 - 0.003 17.2 9.7 0.004 16.7 6.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1387) HlyD PF00529.15 KOO21192.1 - 0.025 13.9 14.1 0.03 13.6 9.8 1.1 1 0 0 1 1 1 0 HlyD family secretion protein DUF4463 PF14703.1 KOO21192.1 - 0.74 10.3 0.1 0.74 10.3 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4463) YscO PF07321.7 KOO21192.1 - 1.2 8.9 21.1 0.43 10.4 10.3 2.1 2 0 0 2 2 2 0 Type III secretion protein YscO DivIVA PF05103.8 KOO21192.1 - 2 8.4 22.7 4 7.5 1.3 2.1 2 0 0 2 2 2 0 DivIVA protein Mnd1 PF03962.10 KOO21192.1 - 3.2 7.3 13.6 1.1 8.9 7.2 1.7 1 1 1 2 2 2 0 Mnd1 family DUF1451 PF07295.6 KOO21192.1 - 6.8 6.4 12.3 5.5 6.7 3.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1451) Pkinase PF00069.20 KOO21193.1 - 4.9e-39 134.0 0.0 7.6e-39 133.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21193.1 - 1.1e-14 54.1 0.0 2.2e-14 53.1 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO21193.1 - 0.00051 19.1 0.9 0.00088 18.3 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Mnd1 PF03962.10 KOO21193.1 - 1.6 8.3 17.7 0.2 11.2 3.7 2.8 2 1 0 2 2 2 0 Mnd1 family Reo_sigmaC PF04582.7 KOO21193.1 - 2.5 7.1 9.5 0.21 10.7 0.7 2.5 1 1 1 2 2 2 0 Reovirus sigma C capsid protein TPR_MLP1_2 PF07926.7 KOO21193.1 - 3.6 7.3 30.1 5.6 6.7 6.4 2.7 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Sec20 PF03908.8 KOO21193.1 - 8.4 6.1 6.6 4.1 7.1 0.3 2.8 2 0 0 2 2 2 0 Sec20 Lebercilin PF15619.1 KOO21193.1 - 9.9 5.5 30.2 0.47 9.8 4.4 3.5 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Methyltransf_26 PF13659.1 KOO21194.1 - 1.2e-06 28.5 0.0 2.3e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Spectrin PF00435.16 KOO21195.1 - 0.013 15.7 0.7 0.021 15.1 0.2 1.5 2 0 0 2 2 2 0 Spectrin repeat DUF892 PF05974.7 KOO21195.1 - 0.019 14.7 0.6 0.023 14.4 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF892) PhdYeFM_antitox PF02604.14 KOO21195.1 - 0.75 9.4 4.0 5.3 6.6 0.0 2.6 1 1 2 3 3 3 0 Antitoxin Phd_YefM, type II toxin-antitoxin system BRCA-2_helical PF09169.5 KOO21196.1 - 0.022 14.3 0.0 0.035 13.6 0.0 1.2 1 0 0 1 1 1 0 BRCA2, helical FAD_binding_3 PF01494.14 KOO21197.1 - 9.1e-18 64.4 0.0 1.1e-07 31.2 0.0 2.8 2 1 0 2 2 2 2 FAD binding domain DAO PF01266.19 KOO21197.1 - 3.1e-09 36.2 0.4 0.0015 17.5 0.1 2.3 2 1 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 KOO21197.1 - 0.00033 19.6 0.1 0.00053 18.9 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 KOO21197.1 - 0.0015 18.4 0.2 0.0036 17.2 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 KOO21197.1 - 0.0034 17.2 0.1 0.0064 16.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 KOO21197.1 - 0.024 13.1 0.0 0.068 11.6 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox PF00070.22 KOO21197.1 - 0.049 14.0 0.1 0.64 10.4 0.1 2.4 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 KOO21197.1 - 0.053 12.3 0.1 0.089 11.6 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.16 KOO21197.1 - 0.085 12.4 0.1 0.15 11.6 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Reo_sigmaC PF04582.7 KOO21199.1 - 0.66 9.0 40.3 0.12 11.5 3.9 5.8 3 2 2 6 6 6 0 Reovirus sigma C capsid protein tRNA-synt_1b PF00579.20 KOO21200.1 - 4.7e-62 209.7 0.0 1e-61 208.6 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) SET PF00856.23 KOO21201.1 - 1.7e-08 34.9 0.0 3.2e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 SET domain UQ_con PF00179.21 KOO21202.1 - 1.5e-36 124.8 0.0 1.8e-36 124.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 KOO21202.1 - 0.097 12.5 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 RWD domain NMD3 PF04981.8 KOO21204.1 - 3.7e-62 209.5 3.4 5.4e-62 208.9 2.3 1.2 1 0 0 1 1 1 1 NMD3 family Nif11 PF07862.6 KOO21204.1 - 0.0015 18.4 0.4 0.0049 16.7 0.3 1.9 1 0 0 1 1 1 1 Nitrogen fixation protein of unknown function Methyltransf_24 PF13578.1 KOO21205.1 - 2.6e-07 31.4 0.0 6.8e-07 30.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO21205.1 - 0.0029 18.1 0.0 0.0096 16.4 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Peptidase_S51 PF03575.12 KOO21206.1 - 5e-09 36.0 0.0 1.6e-08 34.4 0.0 1.8 2 0 0 2 2 2 1 Peptidase family S51 Abhydrolase_5 PF12695.2 KOO21206.1 - 4.2e-05 23.3 0.0 0.00011 21.9 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO21206.1 - 0.00014 21.8 1.7 0.00024 21.0 0.6 1.9 2 1 0 2 2 2 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 KOO21206.1 - 0.014 14.2 0.0 0.032 13.1 0.0 1.5 1 0 0 1 1 1 0 Chlorophyllase enzyme GATase_3 PF07685.9 KOO21206.1 - 0.022 14.3 0.1 0.05 13.2 0.1 1.5 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Chlorophyllase PF07224.6 KOO21206.1 - 0.043 12.5 0.0 0.075 11.8 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase Steroid_dh PF02544.11 KOO21207.1 - 1e-27 96.7 0.6 1.1e-27 96.6 0.4 1.1 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.8 KOO21207.1 - 9.5e-06 25.6 0.2 9.5e-06 25.6 0.1 1.6 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.7 KOO21207.1 - 1.5e-05 24.4 0.1 1.6e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Aminotran_5 PF00266.14 KOO21208.1 - 7.9e-16 57.7 0.0 5.4e-15 54.9 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class-V EF-hand_1 PF00036.27 KOO21208.1 - 9.6e-05 21.4 2.3 0.0011 18.1 0.2 2.5 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO21208.1 - 0.0072 16.1 4.1 0.054 13.3 0.3 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.1 KOO21208.1 - 0.011 15.8 2.8 0.19 11.9 1.6 2.3 1 1 1 2 2 2 0 EF-hand domain pair Toprim PF01751.17 KOO21208.1 - 0.12 12.3 0.1 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Toprim domain Cwf_Cwc_15 PF04889.7 KOO21208.1 - 0.19 11.3 1.1 0.3 10.7 0.8 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SH3_1 PF00018.23 KOO21209.1 - 0.0036 16.6 0.1 2.7 7.4 0.0 2.4 2 0 0 2 2 2 2 SH3 domain Agenet PF05641.7 KOO21209.1 - 0.021 14.9 3.5 0.17 12.0 0.0 3.3 3 1 0 3 3 3 0 Agenet domain DUF2914 PF11141.3 KOO21209.1 - 0.87 9.1 4.1 9.6 5.8 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2914) RR_TM4-6 PF06459.7 KOO21209.1 - 7 6.4 12.2 10 5.9 8.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 HMA PF00403.21 KOO21211.1 - 1.8e-88 290.6 22.6 6.9e-14 51.7 0.2 7.4 7 0 0 7 7 7 7 Heavy-metal-associated domain E1-E2_ATPase PF00122.15 KOO21211.1 - 2.9e-50 170.4 0.0 6.1e-50 169.3 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 KOO21211.1 - 2.2e-47 162.2 4.4 2.2e-47 162.2 3.1 2.7 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO21211.1 - 1e-17 64.9 0.0 7.3e-17 62.1 0.0 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 KOO21211.1 - 6.3e-05 22.6 0.4 0.00058 19.5 0.3 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 KOO21211.1 - 0.011 16.0 0.0 0.024 14.8 0.0 1.6 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Rubis-subs-bind PF09273.6 KOO21212.1 - 0.00099 19.0 0.0 0.0025 17.7 0.0 1.8 1 1 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.23 KOO21212.1 - 0.022 15.0 0.0 0.037 14.3 0.0 1.4 1 0 0 1 1 1 0 SET domain E2F_TDP PF02319.15 KOO21213.1 - 0.079 12.5 0.0 0.22 11.0 0.0 1.8 1 0 0 1 1 1 0 E2F/DP family winged-helix DNA-binding domain Peptidase_C2 PF00648.16 KOO21214.1 - 1.2e-31 109.8 0.0 1.9e-31 109.2 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.17 KOO21214.1 - 0.00056 19.5 0.0 0.0012 18.5 0.0 1.5 1 0 0 1 1 1 1 Calpain large subunit, domain III GWT1 PF06423.7 KOO21215.1 - 4.3e-24 85.1 1.5 6.2e-24 84.6 0.0 2.1 2 0 0 2 2 2 1 GWT1 Ank PF00023.25 KOO21215.1 - 0.045 13.5 0.0 0.14 12.0 0.0 1.9 1 0 0 1 1 1 0 Ankyrin repeat Peptidase_M50 PF02163.17 KOO21216.1 - 0.0097 14.8 0.0 0.018 14.0 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M50 Pkinase PF00069.20 KOO21217.1 - 9e-55 185.6 0.0 1.4e-54 184.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21217.1 - 7.7e-24 84.1 0.0 1.2e-23 83.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PAS_9 PF13426.1 KOO21217.1 - 2.8e-18 66.1 0.0 2.2e-06 27.9 0.0 4.0 3 1 0 3 3 3 3 PAS domain PAS PF00989.19 KOO21217.1 - 6.3e-08 32.3 0.0 0.0019 17.9 0.0 3.6 3 1 0 3 3 3 2 PAS fold Kinase-like PF14531.1 KOO21217.1 - 2.4e-05 23.4 0.0 4.2e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like PAS_4 PF08448.5 KOO21217.1 - 3.8e-05 23.6 0.0 0.0041 17.1 0.0 3.2 3 0 0 3 3 3 1 PAS fold APH PF01636.18 KOO21217.1 - 0.0072 16.0 1.7 0.0072 16.0 1.2 2.4 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 KOO21217.1 - 0.016 14.3 0.5 0.029 13.4 0.4 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 KOO21217.1 - 0.027 13.8 0.1 0.048 12.9 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.6 KOO21217.1 - 0.19 10.5 0.0 0.32 9.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 NHL PF01436.16 KOO21218.1 - 5.8e-22 76.4 6.5 2.2e-09 36.8 0.1 5.3 6 0 0 6 6 6 3 NHL repeat Cu2_monoox_C PF03712.10 KOO21218.1 - 7.5e-13 48.1 0.0 1.3e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain SGL PF08450.7 KOO21218.1 - 1.1e-06 28.1 0.2 0.043 13.1 0.1 2.4 1 1 1 2 2 2 2 SMP-30/Gluconolaconase/LRE-like region Cu2_monooxygen PF01082.15 KOO21218.1 - 2e-06 27.7 0.0 4.7e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain DUF839 PF05787.8 KOO21218.1 - 0.051 12.5 0.1 7.8 5.2 0.0 2.9 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF839) SBBP PF06739.6 KOO21218.1 - 0.065 13.0 0.2 2.4 7.9 0.0 2.9 2 0 0 2 2 2 0 Beta-propeller repeat PHP PF02811.14 KOO21218.1 - 0.14 11.9 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 PHP domain VCBS PF13517.1 KOO21218.1 - 0.3 11.4 1.4 28 5.1 0.0 3.5 4 0 0 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella HC2 PF07382.6 KOO21219.1 - 0.00074 19.4 13.1 0.00085 19.2 9.1 1.2 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 Notch PF00066.12 KOO21221.1 - 2.1e-09 37.5 4.5 2.1e-09 37.5 3.1 1.9 2 0 0 2 2 2 1 LNR domain DUF4501 PF14946.1 KOO21221.1 - 0.051 13.0 1.7 0.11 11.9 1.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4501) WD40 PF00400.27 KOO21222.1 - 1.3e-25 88.2 7.6 1.3e-07 31.1 0.0 4.6 4 0 0 4 4 4 4 WD domain, G-beta repeat PQQ_2 PF13360.1 KOO21222.1 - 0.0049 16.3 0.2 0.014 14.8 0.1 1.8 1 1 0 1 1 1 1 PQQ-like domain DUF3312 PF11768.3 KOO21222.1 - 0.0055 14.9 0.0 0.9 7.6 0.0 2.6 2 1 1 3 3 3 2 Protein of unknown function (DUF3312) PQQ PF01011.16 KOO21222.1 - 0.011 15.2 0.3 0.055 13.0 0.0 2.4 3 0 0 3 3 3 0 PQQ enzyme repeat WD40 PF00400.27 KOO21223.1 - 3.1e-12 45.8 1.0 1e-09 37.8 0.1 2.7 2 0 0 2 2 2 2 WD domain, G-beta repeat TPR_12 PF13424.1 KOO21223.1 - 1.4e-07 31.3 0.2 3.5e-07 30.0 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO21223.1 - 7.8e-05 22.3 2.9 0.0066 16.2 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO21223.1 - 0.00013 21.3 1.6 0.011 15.3 0.2 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOO21223.1 - 0.00038 20.0 0.2 0.00095 18.7 0.2 1.7 1 0 0 1 1 1 1 TPR repeat TPR_7 PF13176.1 KOO21223.1 - 0.00063 19.3 0.0 0.0051 16.5 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO21223.1 - 0.078 12.7 0.2 0.32 10.8 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4471 PF14740.1 KOO21224.1 - 1.8e-66 224.3 0.0 2.9e-66 223.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4471) DUF4470 PF14737.1 KOO21224.1 - 1.1e-22 79.6 0.0 1.9e-22 78.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) YL1_C PF08265.6 KOO21224.1 - 1.2e-13 50.3 0.0 2.5e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain ADPrib_exo_Tox PF03496.9 KOO21225.1 - 5.7e-09 35.4 0.0 9.7e-09 34.7 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme ART PF01129.13 KOO21225.1 - 3.1e-08 32.9 0.0 2.5e-07 30.0 0.0 2.1 1 1 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Peptidase_S26 PF10502.4 KOO21226.1 - 4.3e-06 26.3 0.0 1.8e-05 24.2 0.0 2.0 2 0 0 2 2 2 1 Signal peptidase, peptidase S26 Acyl_transf_3 PF01757.17 KOO21226.1 - 0.023 13.5 1.3 0.026 13.3 0.3 1.4 2 0 0 2 2 2 0 Acyltransferase family Cro PF09048.5 KOO21227.1 - 0.087 12.4 0.5 0.29 10.7 0.1 2.0 1 1 0 1 1 1 0 Cro LRR_6 PF13516.1 KOO21228.1 - 2.7e-10 39.1 0.5 0.00034 20.3 0.0 3.7 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.2 KOO21228.1 - 1.9e-06 27.3 0.1 0.00055 19.5 0.0 2.2 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO21228.1 - 0.0035 17.0 0.0 0.012 15.3 0.0 1.9 1 1 0 1 1 1 1 Leucine rich repeat TPT PF03151.11 KOO21229.1 - 2.7e-29 101.8 7.1 2.7e-29 101.8 4.9 2.3 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 KOO21229.1 - 4.3e-09 36.4 26.2 1.2e-05 25.3 4.7 2.7 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.6 KOO21229.1 - 3.8e-06 26.0 13.2 1.2e-05 24.4 9.1 1.8 1 1 0 1 1 1 1 UAA transporter family AMP-binding PF00501.23 KOO21230.1 - 4.1e-36 124.2 0.5 5e-20 71.2 0.0 2.2 1 1 1 2 2 2 2 AMP-binding enzyme Hexapep PF00132.19 KOO21230.1 - 6.1e-11 41.3 0.7 0.00057 19.2 0.0 4.8 5 0 0 5 5 5 2 Bacterial transferase hexapeptide (six repeats) AMP-binding_C PF13193.1 KOO21230.1 - 2.4e-09 38.0 0.0 1.6e-08 35.3 0.0 2.3 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain PP-binding PF00550.20 KOO21230.1 - 1.6e-05 25.0 0.0 3.4e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Hexapep_2 PF14602.1 KOO21230.1 - 0.015 14.8 8.6 2.1 7.9 0.1 4.6 4 0 0 4 4 4 0 Hexapeptide repeat of succinyl-transferase FeThRed_A PF02941.10 KOO21231.1 - 5e-07 29.5 0.2 6.3e-07 29.2 0.2 1.1 1 0 0 1 1 1 1 Ferredoxin thioredoxin reductase variable alpha chain Mito_carr PF00153.22 KOO21232.1 - 1.7e-19 69.3 9.0 5e-10 38.9 0.5 3.6 2 1 2 4 4 4 3 Mitochondrial carrier protein Asp PF00026.18 KOO21233.1 - 5.5e-77 259.1 0.0 7e-77 258.7 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 KOO21233.1 - 1.7e-05 24.8 0.0 0.00044 20.2 0.0 2.7 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 KOO21233.1 - 0.0017 18.7 0.0 0.28 11.7 0.0 2.8 2 1 0 2 2 2 1 Aspartyl protease RVP PF00077.15 KOO21233.1 - 0.14 12.0 0.0 2.3 8.1 0.0 2.3 2 0 0 2 2 2 0 Retroviral aspartyl protease COG2 PF06148.6 KOO21234.1 - 8.8e-05 22.3 0.2 0.00015 21.5 0.1 1.3 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 CbiN PF02553.10 KOO21234.1 - 0.42 10.6 2.5 4.6 7.3 0.4 2.4 2 0 0 2 2 2 0 Cobalt transport protein component CbiN LRR_4 PF12799.2 KOO21235.1 - 9e-20 69.8 39.8 5.2e-05 22.7 1.5 11.5 8 2 5 13 13 13 9 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO21235.1 - 6.2e-10 38.1 38.1 0.071 13.2 0.0 12.5 11 1 1 12 12 12 3 Leucine Rich repeat LRR_8 PF13855.1 KOO21235.1 - 1.7e-09 37.2 42.9 1.5e-05 24.6 2.4 8.8 7 3 5 12 12 12 7 Leucine rich repeat LRR_1 PF00560.28 KOO21235.1 - 0.0026 17.5 28.2 3.3 8.0 0.0 11.4 13 1 0 13 13 13 2 Leucine Rich Repeat LRR_7 PF13504.1 KOO21235.1 - 0.034 14.3 25.6 14 6.4 0.1 11.0 12 0 0 12 12 12 0 Leucine rich repeat AAA PF00004.24 KOO21235.1 - 0.036 14.2 0.0 1.6 8.9 0.0 3.2 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Ras PF00071.17 KOO21235.1 - 0.093 12.1 0.0 0.2 11.0 0.0 1.5 1 0 0 1 1 1 0 Ras family Miro PF08477.8 KOO21235.1 - 0.12 12.8 0.0 0.38 11.2 0.0 1.9 1 0 0 1 1 1 0 Miro-like protein IQ PF00612.22 KOO21236.1 - 1.1e-06 27.7 11.6 0.022 14.3 0.2 3.5 3 0 0 3 3 3 3 IQ calmodulin-binding motif Abhydrolase_3 PF07859.8 KOO21237.1 - 9.6e-42 142.9 0.2 1.6e-41 142.2 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold KIAA1430 PF13879.1 KOO21237.1 - 3.1e-14 53.1 0.1 5.6e-14 52.3 0.1 1.4 1 0 0 1 1 1 1 KIAA1430 homologue Abhydrolase_5 PF12695.2 KOO21237.1 - 2.5e-06 27.2 0.2 6e-06 26.0 0.1 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2424 PF10340.4 KOO21237.1 - 0.00031 19.4 0.0 0.0016 17.1 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2424) IQ PF00612.22 KOO21237.1 - 0.00076 18.9 3.7 0.85 9.4 0.0 2.9 2 0 0 2 2 2 2 IQ calmodulin-binding motif Pkinase PF00069.20 KOO21238.1 - 1.2e-77 260.5 0.0 1.6e-77 260.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21238.1 - 1.2e-42 145.8 0.0 1.7e-42 145.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO21238.1 - 3e-08 32.9 0.0 6e-08 31.9 0.0 1.5 2 0 0 2 2 2 1 Kinase-like KA1 PF02149.14 KOO21238.1 - 3.4e-07 29.5 0.2 8.9e-07 28.2 0.2 1.7 1 0 0 1 1 1 1 Kinase associated domain 1 APH PF01636.18 KOO21238.1 - 0.0029 17.3 0.0 0.12 12.1 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Totivirus_coat PF05518.6 KOO21238.1 - 0.0035 15.2 3.7 0.0047 14.8 2.6 1.1 1 0 0 1 1 1 1 Totivirus coat protein UBA_2 PF08587.6 KOO21238.1 - 0.0067 16.5 0.2 0.014 15.5 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) Kdo PF06293.9 KOO21238.1 - 0.065 12.2 0.0 0.12 11.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2475 PF10629.4 KOO21239.1 - 0.035 14.3 0.1 0.07 13.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2475) DUF547 PF04784.9 KOO21240.1 - 3.3e-19 68.8 0.0 5.8e-19 68.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF547 Arm PF00514.18 KOO21240.1 - 5.6e-07 29.1 2.4 0.00018 21.2 0.1 3.9 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat Methyltransf_23 PF13489.1 KOO21241.1 - 1.2e-09 38.1 0.0 2e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO21241.1 - 2.1e-07 31.3 0.0 3.9e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO21241.1 - 1.3e-06 28.8 0.0 2.5e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO21241.1 - 0.1 12.1 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.1 KOO21242.1 - 1.1e-09 39.0 2.1 2.9e-09 37.7 0.1 2.9 3 0 0 3 3 3 1 Methyltransferase domain MOR2-PAG1_N PF14222.1 KOO21242.1 - 1.9e-09 36.7 0.2 0.00091 18.0 0.0 2.7 3 0 0 3 3 3 2 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.1 KOO21242.1 - 0.0055 16.5 0.0 0.017 14.9 0.0 1.8 1 0 0 1 1 1 1 Cell morphogenesis C-terminal DEAD PF00270.24 KOO21243.1 - 1.1e-15 57.5 0.0 4.1e-15 55.6 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO21243.1 - 4.1e-07 29.7 0.0 1.2e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 KOO21243.1 - 0.14 10.9 0.0 0.18 10.5 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain TPR_11 PF13414.1 KOO21244.1 - 2.2e-07 30.4 0.4 2.2e-07 30.4 0.3 2.9 2 0 0 2 2 2 1 TPR repeat EamA PF00892.15 KOO21245.1 - 1.5e-08 34.7 23.4 0.00014 21.9 5.1 2.7 2 2 0 2 2 2 2 EamA-like transporter family EmrE PF13536.1 KOO21245.1 - 0.014 15.5 5.3 0.014 15.5 3.7 3.4 2 2 1 3 3 3 0 Multidrug resistance efflux transporter SHIPPO-rpt PF07004.7 KOO21247.1 - 5.9e-05 23.7 18.9 0.55 11.2 0.1 5.5 5 0 0 5 5 5 4 Sperm-tail PG-rich repeat PAP2 PF01569.16 KOO21248.1 - 3.4e-20 72.0 2.4 5.3e-20 71.3 1.6 1.2 1 0 0 1 1 1 1 PAP2 superfamily BTB PF00651.26 KOO21248.1 - 6.8e-09 35.7 0.0 1e-08 35.1 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain LRR_6 PF13516.1 KOO21250.1 - 7.8e-25 84.1 31.1 0.03 14.3 0.1 16.9 18 0 0 18 18 18 6 Leucine Rich repeat LRR_1 PF00560.28 KOO21250.1 - 7.4e-09 34.4 0.4 11 6.4 0.0 9.0 11 0 0 11 11 11 1 Leucine Rich Repeat LRR_4 PF12799.2 KOO21250.1 - 0.0023 17.4 10.9 2.3 7.9 0.2 6.7 6 1 0 6 6 6 2 Leucine Rich repeats (2 copies) Skp1 PF01466.14 KOO21250.1 - 0.021 14.8 0.0 0.062 13.3 0.0 1.7 1 0 0 1 1 1 0 Skp1 family, dimerisation domain 5_nucleotid_C PF02872.13 KOO21250.1 - 0.037 13.9 1.1 5.8 6.8 0.1 2.8 2 0 0 2 2 2 0 5'-nucleotidase, C-terminal domain TM_helix PF05552.7 KOO21250.1 - 0.1 12.2 7.1 22 4.8 0.1 4.5 4 0 0 4 4 4 0 Conserved TM helix PCP PF02429.10 KOO21250.1 - 0.17 11.9 7.3 39 4.3 0.0 5.4 3 2 2 6 6 6 0 Peridinin-chlorophyll A binding protein PBP_like_2 PF12849.2 KOO21250.1 - 0.36 10.2 4.3 1.6 8.1 0.0 3.0 2 1 0 2 2 2 0 PBP superfamily domain LRR_7 PF13504.1 KOO21250.1 - 0.39 11.1 13.3 35 5.2 0.0 7.8 8 0 0 8 8 8 0 Leucine rich repeat EIF_2_alpha PF07541.7 KOO21250.1 - 0.42 10.3 1.1 1.6e+02 1.9 0.0 4.4 5 1 0 5 5 5 0 Eukaryotic translation initiation factor 2 alpha subunit Dus PF01207.12 KOO21251.1 - 7e-46 156.4 0.0 9e-46 156.1 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DUF3142 PF11340.3 KOO21251.1 - 0.097 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3142) SAS4 PF15460.1 KOO21252.1 - 0.42 10.5 2.7 1.3 8.9 1.9 1.9 1 1 0 1 1 1 0 Something about silencing, SAS, complex subunit 4 BAH PF01426.13 KOO21253.1 - 1.9e-13 50.2 0.1 2.4e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 BAH domain Na_H_Exchanger PF00999.16 KOO21254.1 - 3.3e-52 177.3 37.1 4.6e-52 176.8 25.7 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family FG-GAP PF01839.18 KOO21254.1 - 0.026 14.1 0.2 0.062 13.0 0.1 1.7 1 0 0 1 1 1 0 FG-GAP repeat NOT2_3_5 PF04153.13 KOO21255.1 - 2.1e-34 118.2 6.0 3.2e-34 117.6 4.2 1.2 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family MFS_1 PF07690.11 KOO21256.1 - 4.4e-19 68.4 21.6 7.7e-19 67.6 14.9 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Oxidored_molyb PF00174.14 KOO21257.1 - 3.2e-54 182.8 0.0 5.3e-54 182.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.11 KOO21257.1 - 1.3e-45 154.2 0.0 2.6e-45 153.2 0.0 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain FAD_binding_6 PF00970.19 KOO21257.1 - 1.9e-26 92.0 0.0 1.6e-25 89.0 0.0 2.3 3 0 0 3 3 3 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.23 KOO21257.1 - 2.4e-26 91.3 0.0 4.8e-26 90.3 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_1 PF00175.16 KOO21257.1 - 1e-23 83.9 0.0 3.1e-23 82.4 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 KOO21257.1 - 0.00015 21.6 0.0 0.0031 17.4 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain NIR_SIR PF01077.17 KOO21258.1 - 2.6e-49 166.5 0.2 4.3e-34 117.1 0.0 2.6 3 0 0 3 3 3 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.12 KOO21258.1 - 4.1e-38 128.8 0.0 5.2e-18 64.4 0.0 2.5 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain FR47 PF08445.5 KOO21258.1 - 0.079 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein EcKinase PF02958.15 KOO21261.1 - 4.5e-15 55.5 0.0 8.9e-15 54.5 0.0 1.5 1 1 0 1 1 1 1 Ecdysteroid kinase APH PF01636.18 KOO21261.1 - 1.3e-09 38.1 0.1 2.7e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.6 KOO21261.1 - 8.8e-06 24.5 0.0 1.4e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) zf-met PF12874.2 KOO21262.1 - 2.3e-05 24.3 0.7 5.8e-05 23.1 0.5 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type UVR PF02151.14 KOO21262.1 - 0.00087 18.7 3.1 0.0023 17.3 2.2 1.7 1 0 0 1 1 1 1 UvrB/uvrC motif zf-C2H2_jaz PF12171.3 KOO21262.1 - 0.0036 17.4 1.7 0.0043 17.1 0.2 1.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 KOO21262.1 - 0.021 15.1 1.6 6.3 7.3 0.4 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type DNA_pol_A_exo1 PF01612.15 KOO21262.1 - 0.032 13.7 0.0 0.051 13.0 0.0 1.3 1 0 0 1 1 1 0 3'-5' exonuclease DUF3449 PF11931.3 KOO21262.1 - 0.13 11.7 0.0 0.28 10.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) Form_Nir_trans PF01226.12 KOO21263.1 - 2.1e-74 249.6 25.3 2.4e-74 249.3 17.6 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter Metallophos_2 PF12850.2 KOO21264.1 - 9.7e-06 25.4 0.2 0.00011 22.0 0.1 2.2 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Methyltransf_23 PF13489.1 KOO21264.1 - 0.0012 18.5 0.0 0.0029 17.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO21264.1 - 0.013 15.4 2.5 0.035 14.1 0.2 2.5 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.1 KOO21264.1 - 0.034 13.7 0.0 0.29 10.7 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.1 KOO21264.1 - 0.068 13.5 0.1 0.29 11.5 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.7 KOO21264.1 - 0.11 13.0 0.0 0.24 11.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Mob_synth_C PF06463.8 KOO21266.1 - 7e-35 119.5 0.0 1.1e-34 118.8 0.0 1.3 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.16 KOO21266.1 - 8.7e-24 84.5 0.0 1.3e-23 83.9 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.1 KOO21266.1 - 3.5e-05 23.9 0.0 5.5e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.1 KOO21266.1 - 7.4e-05 22.7 0.0 0.00014 21.9 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain Aminotran_1_2 PF00155.16 KOO21267.1 - 8.2e-47 159.8 0.0 9.3e-47 159.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 KOO21267.1 - 0.0002 20.6 0.0 0.00023 20.3 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Myb_DNA-binding PF00249.26 KOO21268.1 - 2.4e-26 91.5 3.7 7.2e-14 51.5 0.1 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO21268.1 - 1.3e-25 89.2 2.9 2.5e-15 56.3 0.1 2.5 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 KOO21268.1 - 0.28 11.3 2.9 1.5 9.0 0.1 2.5 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Sec1 PF00995.18 KOO21269.1 - 6.6e-122 407.9 0.7 7.8e-122 407.7 0.5 1.0 1 0 0 1 1 1 1 Sec1 family Crp PF00325.15 KOO21269.1 - 0.039 13.4 0.0 0.11 11.9 0.0 1.8 1 0 0 1 1 1 0 Bacterial regulatory proteins, crp family EF-hand_1 PF00036.27 KOO21270.1 - 7.1e-14 49.9 8.3 3e-06 26.1 0.1 4.6 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 KOO21270.1 - 9.2e-14 50.0 5.6 9.2e-06 25.1 0.1 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.1 KOO21270.1 - 9.6e-12 44.3 4.1 3.7e-05 23.2 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.1 KOO21270.1 - 1.6e-11 44.1 1.0 0.00029 20.8 0.2 3.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO21270.1 - 3.5e-11 41.9 10.1 0.0014 17.8 0.1 4.6 4 0 0 4 4 4 4 EF hand CENP-Q PF13094.1 KOO21270.1 - 0.00076 19.5 8.7 0.00076 19.5 6.1 2.4 2 0 0 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit ERM PF00769.14 KOO21270.1 - 2.5 7.5 32.8 0.042 13.3 17.0 2.0 2 0 0 2 2 2 0 Ezrin/radixin/moesin family IncA PF04156.9 KOO21270.1 - 8.5 5.9 15.4 0.26 10.8 6.1 1.7 2 0 0 2 2 2 0 IncA protein DUF2262 PF10020.4 KOO21270.1 - 9.3 6.4 9.4 17 5.5 6.5 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2262) ABC1 PF03109.11 KOO21271.1 - 1.2e-25 89.8 0.0 2.9e-25 88.5 0.0 1.6 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 KOO21271.1 - 2.2e-05 24.3 4.5 0.00019 21.2 1.7 3.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.20 KOO21271.1 - 0.0093 15.1 0.0 0.016 14.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SNF2_N PF00176.18 KOO21272.1 - 2.2e-53 180.9 0.0 3.7e-53 180.2 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF3578 PF12102.3 KOO21272.1 - 5.3e-32 110.9 0.0 1.3e-31 109.6 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3578) Helicase_C PF00271.26 KOO21272.1 - 1.6e-14 53.4 0.0 3.6e-14 52.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.19 KOO21272.1 - 1.6e-13 50.1 0.0 4.1e-07 29.5 0.1 3.5 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain zf-CXXC PF02008.15 KOO21272.1 - 6.8e-12 44.9 20.4 4.2e-08 32.8 1.2 2.9 3 0 0 3 3 3 2 CXXC zinc finger domain PHD PF00628.24 KOO21272.1 - 2.4e-11 43.1 4.0 5.4e-11 42.0 2.8 1.7 1 0 0 1 1 1 1 PHD-finger Agenet PF05641.7 KOO21272.1 - 4.9e-10 39.4 0.3 1.5e-05 25.0 0.0 3.6 3 0 0 3 3 3 2 Agenet domain HDA2-3 PF11496.3 KOO21272.1 - 7.5e-08 31.5 0.0 1.4e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.24 KOO21272.1 - 1.8e-05 24.3 0.0 4.2e-05 23.0 0.0 1.6 1 1 0 1 1 1 1 DEAD/DEAH box helicase C1_1 PF00130.17 KOO21272.1 - 0.011 15.4 0.4 0.011 15.4 0.3 1.9 2 0 0 2 2 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_2 PF13831.1 KOO21272.1 - 0.088 12.1 0.2 0.18 11.1 0.1 1.6 1 0 0 1 1 1 0 PHD-finger DUF2318 PF10080.4 KOO21272.1 - 0.17 11.6 0.6 0.4 10.4 0.4 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) Pkinase PF00069.20 KOO21273.1 - 1.6e-42 145.4 0.0 3.9e-42 144.2 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21273.1 - 6.6e-20 71.2 0.0 2.7e-19 69.2 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO21273.1 - 0.0027 16.7 0.0 0.017 14.0 0.0 2.2 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOO21273.1 - 0.0098 14.9 0.0 0.018 14.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Nucleotid_trans PF03407.11 KOO21274.1 - 0.00064 19.5 0.1 0.0015 18.3 0.0 1.5 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase EF-hand_1 PF00036.27 KOO21275.1 - 8e-29 96.7 21.1 1.2e-08 33.6 0.5 4.7 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO21275.1 - 1.7e-22 79.3 12.4 2.2e-11 43.7 1.2 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO21275.1 - 6.2e-21 72.3 13.7 2e-07 30.3 0.4 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO21275.1 - 8.3e-21 72.3 21.9 4.2e-07 29.0 0.4 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO21275.1 - 1.2e-19 69.6 15.9 1e-08 34.6 1.5 4.5 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.1 KOO21275.1 - 0.00068 19.4 0.1 0.23 11.4 0.0 3.3 3 0 0 3 3 3 1 EF-hand domain DUF4370 PF14290.1 KOO21275.1 - 0.036 13.5 0.3 0.54 9.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4370) Lyase_8_N PF08124.6 KOO21275.1 - 0.079 11.8 0.1 0.15 10.9 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide lyase family 8, N terminal alpha-helical domain PMBR PF09373.5 KOO21275.1 - 0.11 12.4 0.0 2.5 8.2 0.0 2.4 2 0 0 2 2 2 0 Pseudomurein-binding repeat EF-hand_4 PF12763.2 KOO21275.1 - 1.4 8.7 4.8 4.5 7.0 0.2 2.6 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand NAD_binding_11 PF14833.1 KOO21276.1 - 4.6e-28 97.7 0.4 1.1e-27 96.5 0.3 1.6 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase HAD_2 PF13419.1 KOO21276.1 - 4.1e-08 33.6 0.0 2.4e-05 24.6 0.0 2.3 1 1 1 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOO21276.1 - 4.6e-07 29.4 0.1 8.5e-07 28.5 0.1 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like LRR_4 PF12799.2 KOO21277.1 - 4.5e-51 169.7 32.4 1.3e-07 31.1 0.4 12.0 7 3 3 10 10 10 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO21277.1 - 7.8e-48 160.0 24.9 2e-09 37.0 0.2 9.3 6 2 4 10 10 10 10 Leucine rich repeat LRR_1 PF00560.28 KOO21277.1 - 1.7e-28 94.2 32.5 0.037 14.0 0.0 18.7 19 1 1 20 20 20 8 Leucine Rich Repeat LRR_7 PF13504.1 KOO21277.1 - 1.7e-16 57.4 47.4 0.12 12.6 0.0 17.6 20 1 0 20 20 20 6 Leucine rich repeat LRR_6 PF13516.1 KOO21277.1 - 3.4e-11 42.0 21.6 4.6 7.6 0.1 13.4 15 1 1 16 16 16 2 Leucine Rich repeat LRR_9 PF14580.1 KOO21277.1 - 7.7e-06 25.5 12.6 0.3 10.6 0.1 5.9 4 1 1 6 6 6 3 Leucine-rich repeat TauE PF01925.14 KOO21279.1 - 0.0036 16.7 15.4 0.16 11.3 10.7 2.4 1 1 0 1 1 1 1 Sulfite exporter TauE/SafE CbtB PF09489.5 KOO21279.1 - 0.089 12.7 2.2 7.6 6.5 0.0 3.1 3 0 0 3 3 3 0 Probable cobalt transporter subunit (CbtB) Bacteriocin_IIc PF10439.4 KOO21279.1 - 0.2 11.8 6.4 0.17 12.0 0.5 2.3 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide NfeD PF01957.13 KOO21279.1 - 1.4 9.0 7.9 0.32 11.1 2.1 2.3 1 1 2 3 3 3 0 NfeD-like C-terminal, partner-binding DUF2231 PF09990.4 KOO21279.1 - 8.1 6.8 8.6 5.3 7.4 2.5 2.6 3 1 0 3 3 3 0 Predicted membrane protein (DUF2231) MFS_1 PF07690.11 KOO21280.1 - 1.1e-28 99.9 27.0 2.3e-17 62.7 2.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3918 PF13056.1 KOO21280.1 - 0.7 9.2 2.8 1.5 8.2 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3918) Pam17 PF08566.5 KOO21280.1 - 2.7 7.6 5.7 4.7 6.8 0.3 2.6 2 1 0 2 2 2 0 Mitochondrial import protein Pam17 SKIP_SNW PF02731.10 KOO21281.1 - 2e-63 212.5 1.9 2e-63 212.5 1.3 1.7 2 0 0 2 2 2 1 SKIP/SNW domain VSP PF03302.8 KOO21282.1 - 0.11 11.1 44.9 0.36 9.4 22.1 3.0 1 1 1 2 2 2 0 Giardia variant-specific surface protein SYS1 PF09801.4 KOO21282.1 - 0.25 11.3 0.9 0.36 10.8 0.7 1.2 1 0 0 1 1 1 0 Integral membrane protein S linking to the trans Golgi network DivIC PF04977.10 KOO21283.1 - 0.0082 15.6 0.6 0.015 14.7 0.4 1.4 1 0 0 1 1 1 1 Septum formation initiator DUF904 PF06005.7 KOO21283.1 - 0.046 14.0 0.5 0.085 13.1 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF904) TMF_TATA_bd PF12325.3 KOO21283.1 - 0.09 12.5 0.1 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding EF-hand_7 PF13499.1 KOO21284.1 - 3.5e-14 52.6 0.5 0.0001 22.3 0.2 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO21284.1 - 1.7e-13 48.8 0.9 0.00034 19.7 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 KOO21284.1 - 6.8e-12 44.2 0.6 0.00048 19.7 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain Mpv17_PMP22 PF04117.7 KOO21284.1 - 4.2e-11 42.3 0.0 7.9e-11 41.4 0.0 1.4 1 0 0 1 1 1 1 Mpv17 / PMP22 family EF-hand_8 PF13833.1 KOO21284.1 - 7.2e-10 38.3 0.6 6.4e-05 22.4 0.1 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO21284.1 - 1.3e-08 33.8 6.4 0.00015 20.9 0.2 3.4 3 1 0 3 3 3 2 EF hand EF-hand_9 PF14658.1 KOO21284.1 - 8.1e-05 22.4 0.0 0.002 17.9 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO21284.1 - 0.00072 19.5 0.0 0.12 12.3 0.0 2.2 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Methyltransf_24 PF13578.1 KOO21285.1 - 2.2e-15 57.3 0.0 3.4e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO21285.1 - 0.00076 20.0 0.0 0.0011 19.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO21285.1 - 0.0032 17.9 0.0 0.0058 17.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO21285.1 - 0.018 15.4 0.0 0.03 14.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF2076 PF09849.4 KOO21286.1 - 8e-06 26.0 13.3 1.6e-05 25.1 9.2 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) TPR_11 PF13414.1 KOO21286.1 - 3.2e-05 23.4 0.1 8.3e-05 22.1 0.1 1.7 1 0 0 1 1 1 1 TPR repeat CHCH PF06747.8 KOO21286.1 - 0.0023 17.8 7.5 0.005 16.7 5.2 1.5 1 0 0 1 1 1 1 CHCH domain DUF681 PF05080.7 KOO21286.1 - 0.014 15.8 1.7 0.032 14.6 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF681) TPR_14 PF13428.1 KOO21286.1 - 0.029 15.0 2.4 0.029 15.0 1.6 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Arm PF00514.18 KOO21288.1 - 9.8e-26 88.6 8.3 8.5e-10 38.0 0.1 4.8 4 0 0 4 4 4 3 Armadillo/beta-catenin-like repeat O-FucT PF10250.4 KOO21288.1 - 5.9e-07 28.9 0.0 1.1e-06 27.9 0.0 1.4 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase HEAT_2 PF13646.1 KOO21288.1 - 0.008 16.4 4.2 0.008 16.4 2.9 2.8 1 1 2 3 3 3 3 HEAT repeats HEAT_EZ PF13513.1 KOO21288.1 - 5 7.7 18.9 0.12 12.9 2.9 4.5 3 2 1 4 4 4 0 HEAT-like repeat K-box PF01486.12 KOO21289.1 - 0.0034 17.1 0.5 0.0059 16.3 0.3 1.3 1 0 0 1 1 1 1 K-box region Alpha_TIF PF02232.10 KOO21289.1 - 0.0064 15.3 0.3 0.0094 14.8 0.2 1.2 1 0 0 1 1 1 1 Alpha trans-inducing protein (Alpha-TIF) TBPIP PF07106.8 KOO21289.1 - 0.022 14.3 1.8 0.028 13.9 1.3 1.1 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) OmpH PF03938.9 KOO21289.1 - 0.044 13.7 2.4 0.06 13.2 1.6 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) PRESAN PF09687.5 KOO21289.1 - 0.079 13.0 0.2 0.11 12.5 0.1 1.1 1 0 0 1 1 1 0 Plasmodium RESA N-terminal DUF4340 PF14238.1 KOO21289.1 - 0.12 12.0 0.2 0.21 11.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4340) Trypan_PARP PF05887.6 KOO21290.1 - 0.74 9.6 10.4 0.12 12.2 4.7 1.5 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Brix PF04427.13 KOO21291.1 - 5.7e-44 150.0 0.3 7.1e-44 149.7 0.2 1.1 1 0 0 1 1 1 1 Brix domain Bromodomain PF00439.20 KOO21291.1 - 0.026 14.4 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 Bromodomain CHDCT2 PF08074.6 KOO21292.1 - 0.17 11.5 11.5 0.13 11.9 6.8 1.7 1 1 0 1 1 1 0 CHDCT2 (NUC038) domain XPA_C PF05181.7 KOO21292.1 - 0.9 9.1 4.2 2.6 7.6 0.3 2.8 2 0 0 2 2 2 0 XPA protein C-terminus DUF2304 PF10066.4 KOO21292.1 - 4.1 7.2 9.7 21 4.9 0.2 3.6 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2304) PP2C PF00481.16 KOO21293.1 - 5e-39 134.2 0.0 6.7e-39 133.8 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 KOO21293.1 - 8.4e-08 31.8 0.5 2.1e-07 30.5 0.3 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOO21293.1 - 0.00015 21.5 0.1 0.0028 17.4 0.0 2.1 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) TIG PF01833.19 KOO21294.1 - 1.3e-19 69.9 8.1 7e-09 35.5 0.5 3.9 4 1 0 4 4 4 3 IPT/TIG domain SMK-1 PF04802.10 KOO21296.1 - 1.5e-57 194.2 0.3 2.8e-57 193.3 0.2 1.5 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 LON PF02190.11 KOO21297.1 - 3.2e-08 33.5 0.1 1.1e-07 31.7 0.1 1.9 1 1 0 1 1 1 1 ATP-dependent protease La (LON) domain Mst1_SARAH PF11629.3 KOO21297.1 - 0.016 15.0 1.7 0.57 10.0 0.6 2.5 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 DUF1328 PF07043.8 KOO21297.1 - 0.18 11.8 1.1 0.32 11.0 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1328) TPR_11 PF13414.1 KOO21298.1 - 1e-05 25.0 3.2 0.014 14.9 0.2 3.2 2 1 1 3 3 3 2 TPR repeat MIT PF04212.13 KOO21298.1 - 0.018 14.9 0.1 0.048 13.5 0.1 1.7 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain TPR_1 PF00515.23 KOO21298.1 - 0.026 14.1 1.7 6.7 6.5 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO21298.1 - 0.051 13.5 8.5 0.088 12.7 0.5 3.3 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO21298.1 - 0.38 10.6 10.5 2 8.3 1.7 3.5 2 2 2 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO21298.1 - 0.67 10.0 7.0 40 4.4 0.0 4.5 4 1 1 5 5 5 0 Tetratricopeptide repeat AAA PF00004.24 KOO21299.1 - 1.6e-94 313.0 0.0 3.2e-46 156.7 0.0 2.9 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) EF-hand_1 PF00036.27 KOO21299.1 - 1.2e-28 96.1 12.6 2.2e-06 26.5 0.2 5.0 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO21299.1 - 1.9e-28 98.3 4.6 4.8e-14 52.2 0.0 3.6 4 0 0 4 4 2 2 EF-hand domain pair CDC48_N PF02359.13 KOO21299.1 - 1e-25 89.4 1.0 2.6e-24 84.9 0.1 3.3 3 0 0 3 3 3 1 Cell division protein 48 (CDC48), N-terminal domain EF-hand_8 PF13833.1 KOO21299.1 - 2.2e-25 87.9 5.9 3.9e-12 45.5 0.2 4.3 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO21299.1 - 3.1e-20 70.1 12.3 5.3e-06 25.8 0.1 5.6 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.1 KOO21299.1 - 3.9e-18 63.8 21.1 1.6e-05 23.9 0.0 5.2 5 0 0 5 5 4 4 EF hand AAA_2 PF07724.9 KOO21299.1 - 2.6e-13 50.2 0.0 2.5e-06 27.5 0.0 3.3 4 0 0 4 4 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 KOO21299.1 - 2.8e-13 49.4 0.0 3.2e-05 23.0 0.0 2.8 3 0 0 3 3 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 KOO21299.1 - 1.3e-12 47.7 0.0 1.9e-06 27.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 KOO21299.1 - 1.7e-12 47.5 0.3 0.00013 22.0 0.0 4.6 4 2 0 4 4 2 2 AAA domain AAA_16 PF13191.1 KOO21299.1 - 7.3e-12 45.6 0.1 0.00032 20.7 0.0 3.7 2 2 1 3 3 3 2 AAA ATPase domain AAA_17 PF13207.1 KOO21299.1 - 7.7e-12 46.0 0.0 0.00012 22.9 0.0 3.3 2 0 0 2 2 2 2 AAA domain CDC48_2 PF02933.12 KOO21299.1 - 8.6e-12 44.5 0.0 1.8e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_5 PF07728.9 KOO21299.1 - 9.9e-11 41.5 0.0 2.6e-05 23.9 0.0 3.3 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 KOO21299.1 - 5.4e-09 35.4 0.0 0.0026 16.8 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin AAA_14 PF13173.1 KOO21299.1 - 5.4e-09 36.0 0.0 0.003 17.4 0.0 2.9 3 0 0 3 3 2 2 AAA domain TIP49 PF06068.8 KOO21299.1 - 3.1e-08 32.7 0.0 0.0013 17.4 0.0 2.5 2 0 0 2 2 2 2 TIP49 C-terminus EF-hand_9 PF14658.1 KOO21299.1 - 2.4e-07 30.5 0.2 0.00013 21.7 0.0 2.9 3 0 0 3 3 2 1 EF-hand domain IstB_IS21 PF01695.12 KOO21299.1 - 3.3e-07 29.8 0.0 0.013 14.9 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.16 KOO21299.1 - 3.9e-07 29.4 0.3 0.032 13.3 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Arch_ATPase PF01637.13 KOO21299.1 - 5.9e-07 29.4 1.5 0.31 10.7 0.0 4.6 4 1 1 5 5 4 2 Archaeal ATPase AAA_18 PF13238.1 KOO21299.1 - 7.7e-07 29.4 0.0 0.066 13.5 0.0 3.0 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.13 KOO21299.1 - 1.5e-06 27.9 0.0 0.0023 17.4 0.0 3.2 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.17 KOO21299.1 - 1.7e-06 28.1 0.0 0.0075 16.4 0.0 3.0 3 0 0 3 3 2 2 RNA helicase AAA_19 PF13245.1 KOO21299.1 - 2.3e-06 27.2 0.6 0.12 12.1 0.0 3.2 2 0 0 2 2 2 2 Part of AAA domain Sigma54_activ_2 PF14532.1 KOO21299.1 - 4e-06 26.9 0.0 0.08 12.9 0.0 2.7 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_28 PF13521.1 KOO21299.1 - 1.1e-05 25.5 0.0 0.22 11.4 0.0 3.2 3 0 0 3 3 3 2 AAA domain ABC_tran PF00005.22 KOO21299.1 - 1.1e-05 25.7 0.1 0.023 15.0 0.0 3.3 2 1 0 2 2 2 1 ABC transporter AAA_25 PF13481.1 KOO21299.1 - 1.5e-05 24.5 5.1 0.42 9.9 0.0 4.3 3 2 1 5 5 4 2 AAA domain Vps4_C PF09336.5 KOO21299.1 - 1.9e-05 24.4 0.4 0.00011 21.9 0.0 2.5 3 0 0 3 3 1 1 Vps4 C terminal oligomerisation domain NACHT PF05729.7 KOO21299.1 - 6.8e-05 22.5 0.1 0.18 11.4 0.0 3.6 3 1 0 4 4 4 1 NACHT domain Sigma54_activat PF00158.21 KOO21299.1 - 8.2e-05 22.1 0.0 0.45 9.9 0.0 3.1 2 1 0 2 2 2 2 Sigma-54 interaction domain KaiC PF06745.8 KOO21299.1 - 8.4e-05 21.7 0.4 2.2 7.3 0.0 3.7 2 1 1 3 3 3 1 KaiC ResIII PF04851.10 KOO21299.1 - 0.00012 21.9 0.0 0.028 14.2 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Parvo_NS1 PF01057.12 KOO21299.1 - 0.00012 21.0 0.1 0.031 13.1 0.0 2.4 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 Bac_DnaA PF00308.13 KOO21299.1 - 0.00038 20.1 0.0 0.77 9.3 0.0 2.6 2 0 0 2 2 2 2 Bacterial dnaA protein NB-ARC PF00931.17 KOO21299.1 - 0.0004 19.3 0.0 0.12 11.1 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain SPARC_Ca_bdg PF10591.4 KOO21299.1 - 0.00041 20.3 0.0 1.4 8.9 0.0 2.6 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region AAA_24 PF13479.1 KOO21299.1 - 0.00075 19.1 0.0 0.45 10.0 0.0 2.9 2 0 0 2 2 2 1 AAA domain PhoH PF02562.11 KOO21299.1 - 0.00096 18.4 0.2 1.1 8.4 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein Cytidylate_kin2 PF13189.1 KOO21299.1 - 0.0011 18.8 0.2 0.17 11.7 0.0 2.9 3 0 0 3 3 2 1 Cytidylate kinase-like family NTPase_1 PF03266.10 KOO21299.1 - 0.0012 18.6 1.1 1.7 8.2 0.0 4.5 5 0 0 5 5 4 1 NTPase AAA_3 PF07726.6 KOO21299.1 - 0.0012 18.4 0.0 1.2 8.6 0.0 3.1 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) SKI PF01202.17 KOO21299.1 - 0.0014 18.5 0.0 2.4 8.0 0.0 3.4 3 0 0 3 3 2 0 Shikimate kinase EF-hand_4 PF12763.2 KOO21299.1 - 0.0015 18.2 0.7 0.1 12.3 0.1 2.5 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand DUF2075 PF09848.4 KOO21299.1 - 0.0053 15.7 0.0 2.4 7.0 0.0 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DUF815 PF05673.8 KOO21299.1 - 0.0071 15.2 0.0 0.24 10.2 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) UFD1 PF03152.9 KOO21299.1 - 0.009 15.1 0.0 0.018 14.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 ATP-synt_ab PF00006.20 KOO21299.1 - 0.017 14.6 0.0 1.4 8.3 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_10 PF12846.2 KOO21299.1 - 0.017 14.5 4.6 2.9 7.2 0.0 4.1 5 0 0 5 5 5 0 AAA-like domain TerB PF05099.8 KOO21299.1 - 0.019 14.7 4.8 0.8 9.4 0.3 3.3 2 1 2 4 4 3 0 Tellurite resistance protein TerB T2SE PF00437.15 KOO21299.1 - 0.02 13.8 0.0 3.6 6.4 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_11 PF13086.1 KOO21299.1 - 0.023 14.2 0.0 16 4.9 0.0 3.3 3 0 0 3 3 3 0 AAA domain UPF0079 PF02367.12 KOO21299.1 - 0.035 13.7 0.0 4.1 7.0 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 KTI12 PF08433.5 KOO21299.1 - 0.036 13.2 0.0 7 5.7 0.0 2.7 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_23 PF13476.1 KOO21299.1 - 0.048 13.9 0.0 5.7 7.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.9 KOO21299.1 - 0.063 12.2 0.0 1.1 8.1 0.0 2.5 2 0 0 2 2 2 0 KAP family P-loop domain AAA_30 PF13604.1 KOO21299.1 - 0.068 12.7 0.1 15 5.1 0.0 3.2 4 0 0 4 4 2 0 AAA domain UPF0154 PF03672.8 KOO21299.1 - 0.077 12.6 0.1 6.9 6.3 0.0 2.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.5 KOO21299.1 - 0.096 12.6 0.0 0.35 10.8 0.0 2.0 1 0 0 1 1 1 0 Ca2+ insensitive EF hand PduV-EutP PF10662.4 KOO21299.1 - 0.12 11.8 0.0 4.5 6.7 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Zot PF05707.7 KOO21299.1 - 0.2 11.1 0.1 19 4.6 0.1 3.4 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) Coatomer_WDAD PF04053.9 KOO21300.1 - 0.0004 19.2 3.0 0.0084 14.9 0.2 3.0 3 0 0 3 3 3 1 Coatomer WD associated region TPR_7 PF13176.1 KOO21300.1 - 0.0012 18.4 9.1 81 3.3 0.0 7.1 6 0 0 6 6 6 0 Tetratricopeptide repeat WD40 PF00400.27 KOO21300.1 - 0.0015 18.3 0.0 0.35 10.8 0.0 4.0 4 0 0 4 4 4 1 WD domain, G-beta repeat Clathrin PF00637.15 KOO21300.1 - 0.0017 18.0 0.8 12 5.5 0.0 3.9 3 1 1 4 4 4 2 Region in Clathrin and VPS IKI3 PF04762.7 KOO21300.1 - 0.0083 14.0 0.0 0.031 12.1 0.0 1.8 2 0 0 2 2 2 1 IKI3 family eIF2A PF08662.6 KOO21300.1 - 0.0086 15.8 0.0 0.14 11.9 0.0 2.5 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A TPR_11 PF13414.1 KOO21300.1 - 0.065 12.8 14.8 0.7 9.5 1.1 5.0 6 0 0 6 6 6 0 TPR repeat TPR_12 PF13424.1 KOO21300.1 - 0.38 10.7 17.7 2.9 7.8 0.1 5.7 5 1 0 5 5 5 0 Tetratricopeptide repeat PPR_2 PF13041.1 KOO21302.1 - 4.1e-18 65.1 0.0 6.4e-06 26.0 0.0 6.4 4 2 3 7 7 7 5 PPR repeat family PPR_3 PF13812.1 KOO21302.1 - 6.7e-15 54.0 16.4 0.0039 17.3 0.0 7.8 8 0 0 8 8 8 4 Pentatricopeptide repeat domain PPR_1 PF12854.2 KOO21302.1 - 3.7e-05 23.1 0.2 0.17 11.3 0.0 5.1 6 0 0 6 6 6 1 PPR repeat PPR PF01535.15 KOO21302.1 - 0.00037 20.2 0.9 4.3 7.5 0.0 5.4 4 1 0 4 4 4 1 PPR repeat FtsJ PF01728.14 KOO21302.1 - 0.15 12.0 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase RNA_pol_A_CTD PF03118.10 KOO21302.1 - 0.24 10.8 0.1 0.49 9.8 0.1 1.5 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain TB2_DP1_HVA22 PF03134.14 KOO21303.1 - 0.0013 18.4 15.3 0.025 14.3 2.8 3.9 3 2 0 3 3 3 2 TB2/DP1, HVA22 family HTH_29 PF13551.1 KOO21304.1 - 0.051 13.7 0.2 0.14 12.3 0.1 1.7 1 0 0 1 1 1 0 Winged helix-turn helix IBR PF01485.16 KOO21304.1 - 0.19 11.6 17.7 0.42 10.5 12.2 1.6 1 1 0 1 1 1 0 IBR domain WD40 PF00400.27 KOO21305.1 - 1.2e-51 170.8 8.5 2.4e-13 49.3 0.2 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat Katanin_con80 PF13925.1 KOO21305.1 - 3.5e-25 88.6 1.1 1.1e-24 87.0 0.0 2.2 2 1 0 2 2 2 1 con80 domain of Katanin eIF2A PF08662.6 KOO21305.1 - 8.1e-07 28.9 0.0 0.0017 18.0 0.0 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 KOO21305.1 - 0.00055 18.2 1.7 3.8 5.5 0.0 3.5 3 2 1 4 4 4 3 Nucleoporin Nup120/160 HEAT PF02985.17 KOO21305.1 - 0.0093 15.9 0.4 0.5 10.5 0.1 3.0 2 0 0 2 2 2 1 HEAT repeat Nucleoporin_N PF08801.6 KOO21305.1 - 0.012 14.3 0.0 1.2 7.8 0.0 2.2 1 1 1 2 2 2 0 Nup133 N terminal like HEAT_2 PF13646.1 KOO21305.1 - 0.059 13.6 0.3 2.8 8.3 0.0 2.5 2 0 0 2 2 2 0 HEAT repeats Cytochrom_D1 PF02239.11 KOO21305.1 - 0.14 10.4 0.0 0.25 9.5 0.0 1.5 1 0 0 1 1 1 0 Cytochrome D1 heme domain SlyX PF04102.7 KOO21306.1 - 0.24 11.7 7.8 0.68 10.3 1.8 2.2 2 0 0 2 2 2 0 SlyX Porin_3 PF01459.17 KOO21307.1 - 5.1e-06 25.9 0.1 0.00055 19.3 0.0 2.1 2 0 0 2 2 2 2 Eukaryotic porin DUF1180 PF06679.7 KOO21307.1 - 0.35 10.7 2.5 0.53 10.1 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Isochorismatase PF00857.15 KOO21308.1 - 4.5e-21 75.5 0.1 5.5e-13 49.2 0.0 2.2 2 0 0 2 2 2 2 Isochorismatase family RNase_T PF00929.19 KOO21309.1 - 2.5e-11 44.1 0.0 5.7e-11 42.9 0.0 1.6 1 1 0 1 1 1 1 Exonuclease Pkinase PF00069.20 KOO21310.1 - 1.7e-47 161.7 0.0 2.1e-47 161.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21310.1 - 6.8e-22 77.7 0.1 9.6e-22 77.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 KOO21310.1 - 0.00019 20.8 0.0 0.00037 19.9 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 KOO21310.1 - 0.0039 16.2 0.0 0.013 14.5 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 KOO21310.1 - 0.021 13.8 0.0 0.037 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO21310.1 - 0.094 12.4 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF1227 PF06777.6 KOO21311.1 - 1.9e-45 154.1 0.2 4e-45 153.0 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1227) DEAD_2 PF06733.10 KOO21311.1 - 1.2e-44 151.8 0.0 3.6e-44 150.2 0.0 1.8 1 1 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.1 KOO21311.1 - 3.6e-42 144.1 0.0 7.9e-42 143.0 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain ResIII PF04851.10 KOO21311.1 - 6.5e-07 29.3 0.0 5.6e-05 23.0 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 KOO21311.1 - 0.0001 21.2 0.1 0.11 11.2 0.0 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain DEAD PF00270.24 KOO21311.1 - 0.0061 16.0 0.0 1.3 8.4 0.0 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase AAA_11 PF13086.1 KOO21311.1 - 0.016 14.8 0.0 0.054 13.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.4 KOO21311.1 - 0.16 10.8 0.0 12 4.6 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) PMM PF03332.8 KOO21312.1 - 5.1e-95 317.2 0.0 6e-95 316.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.7 KOO21312.1 - 1.8e-06 27.7 0.0 3e-06 27.0 0.0 1.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOO21312.1 - 0.013 15.8 0.0 0.019 15.3 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Trehalose_PPase PF02358.11 KOO21312.1 - 0.064 12.1 0.0 0.092 11.6 0.0 1.2 1 0 0 1 1 1 0 Trehalose-phosphatase S6PP PF05116.8 KOO21312.1 - 0.07 12.4 0.0 0.93 8.7 0.0 2.0 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase TPR_12 PF13424.1 KOO21313.1 - 4.5e-44 148.2 36.6 9.8e-18 63.8 1.9 4.6 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.1 KOO21313.1 - 6.6e-28 95.7 48.1 9.7e-09 34.8 0.3 6.6 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_1 PF00515.23 KOO21313.1 - 4.7e-21 73.4 7.4 0.00093 18.7 0.5 6.5 7 0 0 7 7 6 5 Tetratricopeptide repeat TPR_2 PF07719.12 KOO21313.1 - 9.4e-21 72.0 17.6 0.003 17.3 0.0 6.8 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_11 PF13414.1 KOO21313.1 - 1.2e-20 72.9 17.4 5.6e-09 35.5 0.4 4.6 2 1 1 4 4 4 4 TPR repeat TPR_7 PF13176.1 KOO21313.1 - 8e-16 56.5 20.7 0.011 15.5 0.1 7.0 6 1 0 6 6 6 6 Tetratricopeptide repeat TPR_16 PF13432.1 KOO21313.1 - 1.4e-11 44.7 44.0 1.4e-06 28.8 3.2 5.2 1 1 5 6 6 6 5 Tetratricopeptide repeat TPR_14 PF13428.1 KOO21313.1 - 2.1e-10 40.2 41.6 0.035 14.7 0.7 7.1 2 2 3 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.1 KOO21313.1 - 5.6e-10 38.2 0.1 0.11 12.3 0.0 5.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOO21313.1 - 1.1e-07 32.0 25.6 3.8e-05 23.9 0.5 5.4 1 1 4 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO21313.1 - 3.3e-05 23.7 6.2 2.5 8.5 0.1 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat Apc3 PF12895.2 KOO21313.1 - 7.1e-05 22.8 1.6 0.06 13.4 0.4 2.9 2 1 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 KOO21313.1 - 0.00014 22.0 7.4 8.3 7.1 0.1 5.7 5 1 0 5 5 5 0 Tetratricopeptide repeat DUF1442 PF07279.6 KOO21313.1 - 0.008 15.2 0.2 0.18 10.9 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1442) DUF3856 PF12968.2 KOO21313.1 - 0.056 13.2 6.8 0.51 10.1 0.7 3.2 1 1 2 3 3 3 0 Domain of Unknown Function (DUF3856) TPR_4 PF07721.9 KOO21313.1 - 0.19 12.2 0.0 0.19 12.2 0.0 9.7 9 2 1 10 10 7 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO21313.1 - 0.4 10.5 29.7 0.27 11.1 1.0 5.7 3 2 3 6 6 6 0 Tetratricopeptide repeat DUF3366 PF11846.3 KOO21313.1 - 0.72 9.7 6.7 1.9 8.3 0.7 3.0 1 1 1 3 3 3 0 Domain of unknown function (DUF3366) Na_Ca_ex PF01699.19 KOO21314.1 - 9.9e-54 180.7 30.6 8.7e-27 93.4 7.4 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Voldacs PF03517.8 KOO21314.1 - 0.038 13.8 0.1 0.073 12.9 0.1 1.4 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling CPSase_L_D2 PF02786.12 KOO21315.1 - 1.3e-105 351.2 0.0 7e-78 260.7 0.0 2.2 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.17 KOO21315.1 - 3.9e-49 165.5 0.0 7.4e-49 164.5 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.23 KOO21315.1 - 5.5e-40 136.8 0.0 1.7e-39 135.2 0.0 1.9 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.14 KOO21315.1 - 5.7e-40 135.8 0.1 1.3e-39 134.7 0.1 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp_4 PF13535.1 KOO21315.1 - 9.5e-38 129.7 0.0 5.3e-23 81.6 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain CPSase_L_chain PF00289.17 KOO21315.1 - 4.7e-32 110.3 0.0 3.9e-16 59.1 0.0 2.8 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, N-terminal domain ATPgrasp_Ter PF15632.1 KOO21315.1 - 5.4e-22 77.9 0.0 7.5e-12 44.6 0.0 3.8 3 1 0 3 3 3 3 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 KOO21315.1 - 7.8e-19 67.6 0.0 7.2e-11 41.7 0.0 2.3 2 0 0 2 2 2 2 ATP-grasp domain MGS PF02142.17 KOO21315.1 - 9.5e-17 60.7 0.0 2.6e-16 59.3 0.0 1.8 1 0 0 1 1 1 1 MGS-like domain Dala_Dala_lig_C PF07478.8 KOO21315.1 - 1.6e-15 57.0 0.0 2e-08 33.8 0.0 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus Peptidase_C26 PF07722.8 KOO21315.1 - 2e-05 24.1 0.1 0.002 17.6 0.1 2.5 1 1 0 1 1 1 1 Peptidase C26 RimK PF08443.6 KOO21315.1 - 0.00013 21.5 0.0 0.00024 20.6 0.0 1.5 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 KOO21315.1 - 0.0046 16.8 0.0 0.089 12.6 0.0 2.5 2 0 0 2 2 2 1 ATP-grasp domain CoA_binding_2 PF13380.1 KOO21315.1 - 0.073 13.2 0.0 0.95 9.6 0.0 2.7 2 0 0 2 2 2 0 CoA binding domain RNase_T PF00929.19 KOO21316.1 - 8.2e-15 55.4 0.0 9.7e-15 55.2 0.0 1.1 1 0 0 1 1 1 1 Exonuclease TPR_11 PF13414.1 KOO21318.1 - 0.00037 20.0 3.6 0.0015 18.1 0.1 3.1 3 1 0 3 3 3 1 TPR repeat TPR_2 PF07719.12 KOO21318.1 - 0.0018 18.0 0.2 0.71 9.9 0.0 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO21318.1 - 0.0029 17.6 0.1 0.63 10.3 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat Sel1 PF08238.7 KOO21318.1 - 0.072 13.7 4.3 0.081 13.5 0.1 3.0 3 0 0 3 3 3 0 Sel1 repeat TPR_14 PF13428.1 KOO21318.1 - 0.17 12.5 0.1 0.17 12.5 0.1 5.2 3 2 3 6 6 6 0 Tetratricopeptide repeat Steroid_dh PF02544.11 KOO21319.1 - 7.3e-51 171.8 0.0 8.5e-51 171.6 0.0 1.0 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.7 KOO21319.1 - 9.3e-05 21.8 0.0 0.00012 21.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.8 KOO21319.1 - 0.38 10.8 1.9 0.36 10.9 0.3 1.8 2 1 0 2 2 2 0 Phospholipid methyltransferase AAA_23 PF13476.1 KOO21320.1 - 3.1e-25 89.6 0.0 3.1e-25 89.6 0.0 7.2 2 2 1 3 3 1 1 AAA domain AAA_15 PF13175.1 KOO21320.1 - 4.9e-12 45.6 0.2 7.7e-06 25.2 0.0 3.3 2 1 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.1 KOO21320.1 - 3.1e-09 37.2 0.9 0.0022 18.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain SbcCD_C PF13558.1 KOO21320.1 - 1.8e-05 24.5 0.1 0.00044 20.1 0.0 3.0 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.1 KOO21320.1 - 0.0023 17.3 0.0 0.0055 16.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.1 KOO21320.1 - 0.0031 16.0 0.4 0.0031 16.0 0.3 7.1 1 1 6 8 8 7 1 AAA domain ABC_tran PF00005.22 KOO21320.1 - 0.0064 16.7 0.0 0.0064 16.7 0.0 6.2 2 1 1 3 3 1 1 ABC transporter AAA_22 PF13401.1 KOO21320.1 - 0.016 15.3 0.0 0.016 15.3 0.0 5.3 5 0 0 5 5 5 0 AAA domain MobB PF03205.9 KOO21320.1 - 0.023 14.4 0.3 0.31 10.7 0.1 3.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B SMC_N PF02463.14 KOO21320.1 - 4.5 6.4 42.3 59 2.7 29.3 2.5 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain MecA_N PF05223.6 KOO21320.1 - 7.6 6.6 12.2 1.1 9.3 0.2 4.7 3 1 0 4 4 4 0 NTF2-like N-terminal transpeptidase domain UPF0029 PF01205.14 KOO21321.1 - 7.5e-26 89.9 0.0 1.1e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 PPR_2 PF13041.1 KOO21323.1 - 0.00088 19.2 0.1 0.0028 17.5 0.1 1.8 1 1 0 1 1 1 1 PPR repeat family zf-C4H2 PF10146.4 KOO21324.1 - 0.014 15.4 0.0 0.029 14.3 0.0 1.6 1 0 0 1 1 1 0 Zinc finger-containing protein Ribosomal_L19e PF01280.15 KOO21324.1 - 0.061 13.1 0.2 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein L19e Histone PF00125.19 KOO21326.1 - 2.8e-32 110.6 0.4 4.1e-32 110.1 0.3 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 KOO21326.1 - 0.00039 20.5 0.0 0.00068 19.7 0.0 1.4 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 KOO21326.1 - 0.0064 16.5 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T PF15511.1 KOO21326.1 - 0.041 13.1 0.1 0.046 12.9 0.1 1.3 1 1 0 1 1 1 0 Centromere kinetochore component CENP-T Aminotran_1_2 PF00155.16 KOO21330.1 - 1.9e-73 247.5 0.0 2.1e-73 247.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II RAP PF08373.5 KOO21331.1 - 3.5e-15 55.5 0.0 5.3e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 RAP domain FAST_2 PF08368.7 KOO21331.1 - 0.025 14.9 0.0 0.044 14.1 0.0 1.4 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 2 FAST_1 PF06743.10 KOO21331.1 - 0.11 12.2 0.0 1.1 8.9 0.0 2.3 1 1 1 2 2 2 0 FAST kinase-like protein, subdomain 1 DUF1601 PF07671.6 KOO21331.1 - 0.17 11.5 1.1 16 5.2 0.0 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1601) Sulfatase PF00884.18 KOO21332.1 - 1.5e-19 70.3 1.1 2.7e-19 69.5 0.8 1.4 1 0 0 1 1 1 1 Sulfatase LRR_6 PF13516.1 KOO21333.1 - 3.8e-47 153.0 9.5 0.00062 19.5 0.0 10.7 11 0 0 11 11 11 10 Leucine Rich repeat LRR_1 PF00560.28 KOO21333.1 - 2.7e-12 44.8 0.0 8.4 6.8 0.0 9.6 9 1 0 9 9 9 1 Leucine Rich Repeat LRR_4 PF12799.2 KOO21333.1 - 2.5e-10 39.7 18.1 0.099 12.2 0.1 7.3 3 3 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO21333.1 - 1.1e-05 24.8 10.8 25 5.6 0.0 9.0 9 0 0 9 9 9 0 Leucine rich repeat LRR_8 PF13855.1 KOO21333.1 - 2.8e-05 23.7 10.0 0.35 10.6 0.2 6.2 3 2 5 8 8 8 3 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO21333.1 - 0.00019 21.5 6.0 0.7 10.1 0.0 4.8 2 2 2 4 4 4 2 RNA 2'-O ribose methyltransferase substrate binding YycC PF14174.1 KOO21333.1 - 0.15 11.7 0.1 2.5e+02 1.4 0.0 5.1 8 0 0 8 8 8 0 YycC-like protein ART PF01129.13 KOO21334.1 - 2.5e-15 56.2 0.0 3.3e-15 55.7 0.0 1.1 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.9 KOO21334.1 - 9.6e-10 37.9 0.0 1.8e-09 37.1 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Toxin_7 PF05980.7 KOO21334.1 - 0.04 13.9 0.3 0.13 12.3 0.2 1.8 1 0 0 1 1 1 0 Toxin 7 Ribosomal_S17 PF00366.15 KOO21335.1 - 1.4e-15 57.0 0.1 1.8e-15 56.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S17 XPG_I_2 PF12813.2 KOO21336.1 - 6.7e-05 22.4 0.0 0.00011 21.7 0.0 1.2 1 0 0 1 1 1 1 XPG domain containing XPG_I PF00867.13 KOO21336.1 - 0.0029 17.6 0.0 0.0074 16.3 0.0 1.8 1 0 0 1 1 1 1 XPG I-region CoA_trans PF01144.18 KOO21337.1 - 3.4e-97 323.8 0.5 4.2e-60 202.6 0.0 2.3 2 0 0 2 2 2 2 Coenzyme A transferase DUF1295 PF06966.7 KOO21337.1 - 2.1e-13 50.1 0.2 3.2e-13 49.5 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.9 KOO21337.1 - 3.4e-05 23.9 0.0 8.3e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family AcetylCoA_hyd_C PF13336.1 KOO21337.1 - 0.00018 21.2 0.0 0.00041 20.0 0.0 1.5 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain PEMT PF04191.8 KOO21337.1 - 0.00018 21.5 0.6 0.0007 19.6 0.2 2.2 1 1 1 2 2 2 1 Phospholipid methyltransferase Crystall PF00030.14 KOO21337.1 - 0.023 14.5 0.0 0.76 9.7 0.0 2.4 2 0 0 2 2 2 0 Beta/Gamma crystallin ERG4_ERG24 PF01222.12 KOO21337.1 - 0.046 12.2 0.1 0.16 10.4 0.1 1.7 1 1 0 1 1 1 0 Ergosterol biosynthesis ERG4/ERG24 family Steroid_dh PF02544.11 KOO21337.1 - 0.15 11.8 0.0 0.29 10.8 0.0 1.4 1 0 0 1 1 1 0 3-oxo-5-alpha-steroid 4-dehydrogenase TIR_2 PF13676.1 KOO21338.1 - 3e-06 27.3 0.0 3.2e-05 24.0 0.0 2.6 2 0 0 2 2 2 1 TIR domain TRP PF06011.7 KOO21339.1 - 1.1e-05 24.2 18.5 0.00017 20.3 10.6 3.3 2 1 0 2 2 2 1 Transient receptor potential (TRP) ion channel Asp PF00026.18 KOO21340.1 - 9.8e-59 199.1 0.0 1.3e-43 149.4 0.0 2.0 1 1 1 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.1 KOO21340.1 - 3.3e-08 33.6 0.0 4.7e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 KOO21340.1 - 0.047 13.2 0.0 0.088 12.3 0.0 1.4 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal RasGAP PF00616.14 KOO21341.1 - 5.3e-13 49.0 0.0 1e-05 25.3 0.0 2.3 2 0 0 2 2 2 2 GTPase-activator protein for Ras-like GTPase PDZ PF00595.19 KOO21341.1 - 1.6e-06 28.1 0.0 4.9e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) UBA PF00627.26 KOO21341.1 - 1.8e-06 27.6 0.0 3e-05 23.7 0.0 3.0 2 0 0 2 2 2 1 UBA/TS-N domain Nucleoplasmin PF03066.10 KOO21341.1 - 0.23 10.9 8.0 0.54 9.7 5.5 1.5 1 0 0 1 1 1 0 Nucleoplasmin Sigma70_ner PF04546.8 KOO21341.1 - 2.3 7.7 6.8 0.59 9.7 1.8 2.0 2 0 0 2 2 2 0 Sigma-70, non-essential region PBP1_TM PF14812.1 KOO21341.1 - 7 7.0 9.8 19 5.6 6.8 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PNK3P PF08645.6 KOO21342.1 - 1.5e-28 99.2 0.0 1.9e-28 98.8 0.0 1.1 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase zf-CCHH PF10283.4 KOO21342.1 - 1.8e-06 27.6 4.0 3.3e-06 26.7 2.8 1.5 1 0 0 1 1 1 1 Zinc-finger (CX5CX6HX5H) motif Hydrolase_6 PF13344.1 KOO21342.1 - 0.043 13.7 0.0 0.08 12.8 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 KOO21342.1 - 0.055 13.6 0.1 0.17 12.0 0.0 1.9 1 1 1 2 2 2 0 Haloacid dehalogenase-like hydrolase TPR_12 PF13424.1 KOO21343.1 - 1.4e-63 210.7 24.5 3e-17 62.3 0.9 4.7 2 1 4 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.1 KOO21343.1 - 1.2e-57 190.2 25.1 5.6e-11 41.9 0.1 7.1 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_1 PF00515.23 KOO21343.1 - 1.1e-20 72.2 2.6 0.0015 18.0 0.1 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.12 KOO21343.1 - 3.5e-17 60.8 9.3 0.0076 16.0 0.1 6.4 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.1 KOO21343.1 - 1.3e-15 55.9 1.9 0.018 14.7 0.0 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.1 KOO21343.1 - 1.1e-14 52.9 11.9 0.0017 17.9 0.0 5.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.1 KOO21343.1 - 4.4e-14 51.8 5.7 2.1e-05 24.0 0.5 4.5 1 1 5 6 6 6 6 TPR repeat TPR_16 PF13432.1 KOO21343.1 - 3.4e-11 43.5 32.5 2.2e-05 25.0 1.3 6.0 4 1 3 7 7 6 4 Tetratricopeptide repeat TPR_4 PF07721.9 KOO21343.1 - 9.8e-09 34.8 8.5 0.33 11.4 0.1 7.8 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO21343.1 - 3.2e-08 33.1 2.8 2.8 8.3 0.0 5.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOO21343.1 - 6.9e-08 32.4 27.7 0.23 12.2 0.2 7.4 4 2 3 7 7 6 4 Tetratricopeptide repeat TPR_19 PF14559.1 KOO21343.1 - 3.6e-06 27.1 15.5 0.083 13.2 3.6 4.2 2 2 1 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOO21343.1 - 0.0002 21.5 4.0 25 5.6 0.1 5.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_3 PF07720.7 KOO21343.1 - 0.002 17.8 0.0 10 6.0 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Osmo_CC PF08946.5 KOO21343.1 - 0.1 12.6 8.3 28 4.8 0.0 6.4 8 0 0 8 8 8 0 Osmosensory transporter coiled coil DUF3368 PF11848.3 KOO21343.1 - 2.4 7.7 7.0 44 3.7 0.2 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF3368) LRR_6 PF13516.1 KOO21344.1 - 0.0021 17.9 0.0 0.0059 16.5 0.0 1.7 1 0 0 1 1 1 1 Leucine Rich repeat TPR_12 PF13424.1 KOO21348.1 - 1.7e-42 143.2 2.8 1.6e-16 59.9 0.0 3.5 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.1 KOO21348.1 - 1.1e-23 82.3 5.8 3.3e-07 30.0 0.0 4.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO21348.1 - 1.1e-09 37.4 1.6 0.017 15.0 0.0 4.3 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO21348.1 - 2e-09 36.9 0.0 2.9e-07 30.0 0.0 2.8 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 KOO21348.1 - 5.6e-09 35.2 0.2 0.0076 15.8 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO21348.1 - 3.9e-08 32.4 0.1 0.0022 17.6 0.0 4.1 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO21348.1 - 2.7e-05 24.3 12.4 0.083 13.5 0.0 6.1 3 2 3 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO21348.1 - 0.0013 19.3 0.1 0.0013 19.3 0.1 4.7 4 2 1 5 5 4 1 Tetratricopeptide repeat DUF3584 PF12128.3 KOO21348.1 - 0.12 9.7 10.5 0.16 9.2 7.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF3138 PF11336.3 KOO21348.1 - 0.16 10.1 7.4 0.28 9.3 5.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Bap31 PF05529.7 KOO21348.1 - 1.5 8.2 6.0 35 3.7 4.1 2.3 1 1 0 1 1 1 0 B-cell receptor-associated protein 31-like Tropomyosin_1 PF12718.2 KOO21348.1 - 3.2 7.5 16.0 0.2 11.5 2.4 2.6 1 1 0 2 2 2 0 Tropomyosin like CCDC144C PF14915.1 KOO21348.1 - 8.2 5.2 11.8 20 3.9 8.2 1.6 1 1 0 1 1 1 0 CCDC144C protein coiled-coil region Glyco_transf_34 PF05637.7 KOO21349.1 - 0.023 14.2 0.1 0.048 13.1 0.1 1.5 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family tRNA-synt_1 PF00133.17 KOO21349.1 - 0.047 11.6 0.2 0.067 11.1 0.1 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) Glyco_tranf_2_3 PF13641.1 KOO21350.1 - 7.1e-31 107.7 0.0 9.7e-31 107.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 KOO21350.1 - 5.5e-20 71.8 15.6 5.5e-20 71.8 10.8 2.5 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.1 KOO21350.1 - 1.2e-10 40.9 0.0 2.2e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 KOO21350.1 - 7.8e-07 28.9 0.0 1.3e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Chitin_synth_2 PF03142.10 KOO21350.1 - 2e-05 23.2 3.0 0.0069 14.8 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase FSH1 PF03959.8 KOO21351.1 - 1.6e-13 50.6 0.0 2.3e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) 2OG-FeII_Oxy_3 PF13640.1 KOO21351.1 - 0.0064 16.9 0.0 0.014 15.9 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DLH PF01738.13 KOO21351.1 - 0.018 14.2 0.6 0.17 11.1 0.1 2.4 2 1 0 2 2 2 0 Dienelactone hydrolase family 2OG-FeII_Oxy_4 PF13661.1 KOO21351.1 - 0.023 14.3 0.0 0.054 13.1 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Abhydrolase_5 PF12695.2 KOO21351.1 - 0.023 14.4 0.3 0.037 13.7 0.2 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Ion_trans PF00520.26 KOO21352.1 - 8.8e-17 61.0 3.7 1.5e-16 60.2 2.6 1.3 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO21352.1 - 1.8e-09 37.2 2.1 1.8e-09 37.2 1.4 2.2 2 0 0 2 2 2 1 Ion channel cNMP_binding PF00027.24 KOO21352.1 - 0.013 15.2 0.0 0.052 13.3 0.0 1.9 1 1 0 1 1 1 0 Cyclic nucleotide-binding domain ARL2_Bind_BART PF11527.3 KOO21353.1 - 3.8e-05 23.4 0.4 5.8e-05 22.8 0.3 1.3 1 1 0 1 1 1 1 The ARF-like 2 binding protein BART RXT2_N PF08595.6 KOO21354.1 - 0.24 11.1 1.7 0.31 10.8 1.2 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal Nop14 PF04147.7 KOO21354.1 - 0.52 8.1 3.7 0.49 8.2 2.5 1.0 1 0 0 1 1 1 0 Nop14-like family DUF4611 PF15387.1 KOO21354.1 - 0.83 9.8 7.0 1.5 9.0 4.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) AA_permease_2 PF13520.1 KOO21355.1 - 9.4e-21 73.8 12.6 1.2e-20 73.4 8.8 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KOO21355.1 - 4.4e-08 31.8 12.9 4.8e-07 28.4 8.9 1.9 1 1 0 1 1 1 1 Amino acid permease MASE2 PF05230.6 KOO21355.1 - 2.9 7.9 8.0 0.48 10.4 1.8 2.3 2 1 0 2 2 2 0 MASE2 domain Fmp27 PF10344.4 KOO21356.1 - 0.012 13.3 1.2 0.011 13.4 0.8 1.1 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 FAM75 PF14650.1 KOO21356.1 - 0.79 9.0 3.8 1 8.7 2.6 1.2 1 0 0 1 1 1 0 FAM75 family LRR_6 PF13516.1 KOO21357.1 - 1.9e-11 42.7 0.4 0.00071 19.3 0.0 4.6 4 0 0 4 4 4 2 Leucine Rich repeat LRR_4 PF12799.2 KOO21357.1 - 2.5e-06 26.9 0.0 0.091 12.4 0.0 3.3 2 2 1 3 3 3 2 Leucine Rich repeats (2 copies) WW PF00397.21 KOO21357.1 - 4.8e-06 26.3 0.0 9.4e-06 25.3 0.0 1.5 1 0 0 1 1 1 1 WW domain MMR_HSR1 PF01926.18 KOO21357.1 - 5.9e-05 23.0 0.0 0.00013 21.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 KOO21357.1 - 0.00077 18.6 0.0 0.0015 17.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Miro PF08477.8 KOO21357.1 - 0.012 16.1 0.0 0.023 15.1 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein Dynamin_N PF00350.18 KOO21357.1 - 0.02 14.7 0.1 0.083 12.6 0.1 2.0 2 1 1 3 3 3 0 Dynamin family IIGP PF05049.8 KOO21357.1 - 0.03 13.1 0.0 0.049 12.4 0.0 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) LRR_7 PF13504.1 KOO21357.1 - 0.031 14.4 1.1 16 6.2 0.0 4.4 5 0 0 5 5 4 0 Leucine rich repeat AAA_16 PF13191.1 KOO21357.1 - 0.05 13.5 5.6 0.023 14.6 0.6 2.6 2 1 0 2 2 2 0 AAA ATPase domain LRR_1 PF00560.28 KOO21357.1 - 0.061 13.3 0.1 16 6.0 0.0 3.8 3 1 1 4 4 4 0 Leucine Rich Repeat LRR_8 PF13855.1 KOO21357.1 - 0.065 12.9 0.6 4.8 7.0 0.0 3.0 2 2 0 2 2 2 0 Leucine rich repeat ABC_tran PF00005.22 KOO21357.1 - 0.097 12.9 0.0 0.27 11.5 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AIG1 PF04548.11 KOO21357.1 - 0.15 11.1 0.1 0.29 10.2 0.0 1.4 1 0 0 1 1 1 0 AIG1 family AAA_23 PF13476.1 KOO21357.1 - 0.25 11.6 0.0 0.39 11.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.1 KOO21358.1 - 5.8e-21 75.1 0.0 3.1e-20 72.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_12 PF13087.1 KOO21358.1 - 2.3e-17 63.0 0.0 3.4e-17 62.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOO21358.1 - 2.4e-05 24.0 0.4 0.00011 21.8 0.3 2.2 1 0 0 1 1 1 1 Part of AAA domain CSD PF00313.17 KOO21358.1 - 5.7e-05 22.8 0.0 9.3e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain AAA_22 PF13401.1 KOO21358.1 - 0.032 14.3 0.4 6.7 6.8 0.0 3.5 3 1 1 4 4 4 0 AAA domain Mito_fiss_reg PF05308.6 KOO21358.1 - 5 6.4 12.4 8.7 5.6 6.9 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator DUF148 PF02520.12 KOO21359.1 - 0.25 11.1 1.5 0.25 11.1 0.4 1.4 2 0 0 2 2 2 0 Domain of unknown function DUF148 FA_desaturase PF00487.19 KOO21360.1 - 1.4e-36 126.2 24.9 1.8e-36 125.8 17.3 1.1 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.23 KOO21360.1 - 9.9e-11 41.2 0.0 3.1e-10 39.7 0.0 1.8 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Cupin_8 PF13621.1 KOO21361.1 - 1.6e-41 142.4 0.0 3.6e-41 141.3 0.0 1.6 2 0 0 2 2 2 1 Cupin-like domain TPR_11 PF13414.1 KOO21361.1 - 1.2e-13 50.4 24.6 0.00014 21.4 0.5 5.1 3 2 3 6 6 6 5 TPR repeat TPR_2 PF07719.12 KOO21361.1 - 2.3e-10 39.5 24.9 0.45 10.5 0.4 8.3 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.23 KOO21361.1 - 1.2e-07 31.0 11.2 0.031 13.8 0.4 5.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOO21361.1 - 3.7e-07 29.9 33.5 0.0062 16.4 2.7 6.8 6 1 2 8 8 8 6 Tetratricopeptide repeat TPR_16 PF13432.1 KOO21361.1 - 0.0004 20.9 1.7 0.0004 20.9 1.2 6.4 4 2 3 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO21361.1 - 0.0004 20.3 0.2 0.049 13.8 0.1 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO21361.1 - 0.00086 18.9 1.5 6.4 6.8 0.0 4.3 5 0 0 5 5 5 2 Tetratricopeptide repeat JmjC PF02373.17 KOO21361.1 - 0.034 14.4 0.0 0.074 13.3 0.0 1.6 1 0 0 1 1 1 0 JmjC domain, hydroxylase Alginate_exp PF13372.1 KOO21361.1 - 0.04 12.5 0.1 0.068 11.7 0.0 1.3 1 0 0 1 1 1 0 Alginate export Cupin_4 PF08007.7 KOO21361.1 - 0.069 12.3 0.0 0.66 9.1 0.0 2.3 2 0 0 2 2 2 0 Cupin superfamily protein TPR_7 PF13176.1 KOO21361.1 - 1.2 9.1 16.3 0.26 11.1 0.2 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO21361.1 - 5.3 7.9 48.9 1.2 9.9 0.4 9.0 6 2 3 9 9 9 0 Tetratricopeptide repeat ABC_tran PF00005.22 KOO21362.1 - 1.8e-46 157.8 0.0 1.5e-28 99.7 0.0 2.7 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 KOO21362.1 - 9e-19 67.9 5.4 1.4e-18 67.2 3.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_17 PF13207.1 KOO21362.1 - 2.2e-08 34.9 0.0 0.014 16.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 KOO21362.1 - 2.4e-06 26.9 5.0 0.019 14.4 0.1 3.3 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_25 PF13481.1 KOO21362.1 - 2.9e-06 26.8 0.4 0.14 11.5 0.4 3.1 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.1 KOO21362.1 - 4.6e-06 26.7 1.6 0.14 12.1 0.1 3.6 4 0 0 4 4 4 2 AAA ATPase domain AAA_21 PF13304.1 KOO21362.1 - 1.1e-05 25.5 0.1 0.44 10.4 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_10 PF12846.2 KOO21362.1 - 1.2e-05 24.9 1.8 0.35 10.2 0.2 3.5 3 0 0 3 3 3 2 AAA-like domain SMC_N PF02463.14 KOO21362.1 - 4.4e-05 22.8 4.4 0.027 13.6 0.0 4.0 3 1 1 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 KOO21362.1 - 5.5e-05 23.3 0.4 1.4 9.0 0.3 3.8 3 1 0 3 3 3 1 AAA domain DUF87 PF01935.12 KOO21362.1 - 6.1e-05 22.9 1.4 0.13 12.1 0.1 2.7 3 0 0 3 3 2 2 Domain of unknown function DUF87 MobB PF03205.9 KOO21362.1 - 0.00013 21.6 0.4 0.26 11.0 0.0 2.6 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 KOO21362.1 - 0.00018 21.8 0.2 0.7 10.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.1 KOO21362.1 - 0.00041 20.2 0.2 1.3 8.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 KOO21362.1 - 0.00066 18.9 0.6 0.62 9.2 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 ArgK PF03308.11 KOO21362.1 - 0.0017 17.1 0.4 0.29 9.8 0.0 2.4 2 0 0 2 2 2 1 ArgK protein ATP-synt_ab PF00006.20 KOO21362.1 - 0.0031 17.0 0.4 0.81 9.1 0.1 2.5 2 1 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain Zeta_toxin PF06414.7 KOO21362.1 - 0.0036 16.4 0.4 2.1 7.3 0.0 2.7 3 0 0 3 3 3 2 Zeta toxin FtsK_SpoIIIE PF01580.13 KOO21362.1 - 0.0052 16.2 1.2 0.94 8.9 0.0 2.8 2 1 0 3 3 3 1 FtsK/SpoIIIE family NB-ARC PF00931.17 KOO21362.1 - 0.0062 15.4 0.8 2.9 6.6 0.0 2.8 3 0 0 3 3 3 1 NB-ARC domain APS_kinase PF01583.15 KOO21362.1 - 0.0074 15.9 0.4 4.4 6.9 0.0 2.5 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_24 PF13479.1 KOO21362.1 - 0.012 15.2 0.1 1.4 8.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 KOO21362.1 - 0.019 14.6 0.1 1.6 8.3 0.1 2.5 2 0 0 2 2 2 0 NTPase MMR_HSR1 PF01926.18 KOO21362.1 - 0.022 14.7 4.3 1.4 8.8 0.8 3.0 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_5 PF07728.9 KOO21362.1 - 0.023 14.4 0.6 15 5.2 0.1 3.3 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) SbcCD_C PF13558.1 KOO21362.1 - 0.047 13.6 0.3 0.22 11.4 0.2 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit ABC_ATPase PF09818.4 KOO21362.1 - 0.053 12.0 0.1 0.053 12.0 0.0 2.0 3 0 0 3 3 3 0 Predicted ATPase of the ABC class NACHT PF05729.7 KOO21362.1 - 0.067 12.8 1.5 9.5 5.8 0.2 2.6 2 0 0 2 2 2 0 NACHT domain ATP_bind_1 PF03029.12 KOO21362.1 - 0.071 12.6 0.8 3.1 7.2 0.1 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Miro PF08477.8 KOO21362.1 - 0.12 12.8 5.5 2 8.9 0.8 2.9 2 1 0 2 2 2 0 Miro-like protein PRK PF00485.13 KOO21362.1 - 0.15 11.5 0.7 7.8 5.9 0.0 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family RNA_helicase PF00910.17 KOO21362.1 - 0.25 11.5 0.3 22 5.2 0.0 2.5 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.1 KOO21362.1 - 0.54 10.2 5.2 9.7 6.1 0.4 3.4 3 1 0 3 3 3 0 AAA domain DnaG_DnaB_bind PF08278.6 KOO21363.1 - 0.12 12.5 2.2 0.19 11.9 0.5 1.9 1 1 0 2 2 2 0 DNA primase DnaG DnaB-binding MRP-L47 PF06984.8 KOO21364.1 - 4.3e-21 74.6 0.4 7.4e-21 73.8 0.3 1.4 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Ribosomal_L29 PF00831.18 KOO21364.1 - 0.0098 15.5 2.3 0.023 14.3 1.6 1.7 1 0 0 1 1 1 1 Ribosomal L29 protein TarH PF02203.10 KOO21364.1 - 0.063 13.1 0.9 0.13 12.1 0.6 1.5 1 0 0 1 1 1 0 Tar ligand binding domain homologue CIA30 PF08547.7 KOO21365.1 - 2.9e-21 75.9 0.0 3.9e-21 75.5 0.0 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) Adaptin_N PF01602.15 KOO21367.1 - 5.5e-86 288.9 0.0 7e-86 288.6 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 KOO21367.1 - 9.9e-10 38.5 16.4 7.1e-05 23.0 0.2 5.9 4 2 2 6 6 6 4 HEAT repeats Cnd1 PF12717.2 KOO21367.1 - 1.3e-08 34.8 0.1 0.0027 17.5 0.0 3.5 1 1 2 3 3 3 3 non-SMC mitotic condensation complex subunit 1 DUF2435 PF10363.4 KOO21367.1 - 0.00028 20.7 0.4 0.61 10.0 0.0 3.8 2 2 2 4 4 4 2 Protein of unknown function (DUF2435) HEAT PF02985.17 KOO21367.1 - 0.0003 20.6 10.1 1.3 9.2 0.1 6.5 7 0 0 7 7 7 2 HEAT repeat HEAT_EZ PF13513.1 KOO21367.1 - 0.031 14.7 27.8 0.16 12.5 0.2 6.4 6 2 1 7 7 7 0 HEAT-like repeat Ric8 PF10165.4 KOO21367.1 - 0.079 11.7 1.0 0.14 10.9 0.7 1.4 1 0 0 1 1 1 0 Guanine nucleotide exchange factor synembryn XPC-binding PF09280.6 KOO21367.1 - 0.081 12.3 0.7 4.2 6.8 0.0 3.8 4 0 0 4 4 4 0 XPC-binding domain Filamin PF00630.14 KOO21368.1 - 2.2e-45 153.3 0.0 9e-13 48.6 0.0 7.3 7 0 0 7 7 7 5 Filamin/ABP280 repeat CAP_GLY PF01302.20 KOO21368.1 - 3e-15 55.6 0.4 6.6e-15 54.5 0.3 1.6 1 0 0 1 1 1 1 CAP-Gly domain C2 PF00168.25 KOO21368.1 - 6.7e-15 54.7 0.0 1.7e-14 53.3 0.0 1.7 1 0 0 1 1 1 1 C2 domain Big_1 PF02369.11 KOO21368.1 - 8.6e-06 25.5 0.0 0.0035 17.2 0.0 3.5 3 0 0 3 3 3 1 Bacterial Ig-like domain (group 1) Y_Y_Y PF07495.8 KOO21368.1 - 0.02 14.6 0.0 1.4 8.7 0.0 2.6 2 0 0 2 2 2 0 Y_Y_Y domain Neurexophilin PF06312.7 KOO21368.1 - 0.092 11.9 0.0 0.46 9.6 0.0 2.0 2 0 0 2 2 2 0 Neurexophilin EF-hand_8 PF13833.1 KOO21369.1 - 3.5e-13 48.9 2.2 4.4e-07 29.4 0.3 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO21369.1 - 4.5e-10 38.5 4.0 0.0023 17.6 0.2 4.0 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.27 KOO21369.1 - 7.7e-10 37.3 3.0 0.016 14.5 0.2 3.9 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.1 KOO21369.1 - 8.7e-10 38.6 2.1 8.6e-05 22.6 0.1 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO21369.1 - 7e-05 21.9 3.7 1.6 8.2 0.2 3.6 3 0 0 3 3 3 3 EF hand Armet PF10208.4 KOO21369.1 - 0.026 14.2 0.4 0.89 9.2 0.0 2.4 2 1 0 2 2 2 0 Degradation arginine-rich protein for mis-folding Ion_trans PF00520.26 KOO21370.1 - 1.5e-15 57.0 3.8 2.7e-15 56.1 2.6 1.4 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO21370.1 - 3.9e-06 26.4 7.5 3.9e-06 26.4 5.2 2.1 2 0 0 2 2 2 1 Ion channel Ion_trans_N PF08412.5 KOO21370.1 - 0.0023 17.1 0.3 0.012 14.9 0.0 2.3 2 1 0 2 2 2 1 Ion transport protein N-terminal EF-hand_7 PF13499.1 KOO21372.1 - 5.7e-12 45.5 0.2 1.8e-06 27.9 0.0 2.5 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO21372.1 - 5.8e-11 40.8 0.0 0.00039 19.5 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO21372.1 - 6.8e-11 41.1 0.1 0.00063 19.4 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO21372.1 - 7.7e-08 31.3 0.0 0.00043 19.4 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO21372.1 - 1.6e-07 30.8 0.0 0.013 15.1 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair Sel1 PF08238.7 KOO21372.1 - 1.5e-06 28.6 7.0 0.89 10.2 0.1 5.4 4 1 1 5 5 5 2 Sel1 repeat Fis1_TPR_N PF14852.1 KOO21372.1 - 0.025 13.8 0.1 0.054 12.8 0.1 1.6 1 0 0 1 1 1 0 Fis1 N-terminal tetratricopeptide repeat EF-hand_10 PF14788.1 KOO21372.1 - 0.13 11.9 0.1 0.4 10.3 0.0 1.8 2 0 0 2 2 2 0 EF hand PapD-like PF14874.1 KOO21374.1 - 0.0001 22.1 0.0 0.0024 17.7 0.0 2.6 3 0 0 3 3 3 1 Flagellar-associated PapD-like Paf67 PF10255.4 KOO21375.1 - 2.3e-140 468.0 0.0 3e-140 467.6 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 NusB PF01029.13 KOO21375.1 - 0.0027 17.6 0.1 0.0076 16.2 0.0 1.7 1 0 0 1 1 1 1 NusB family TPR_2 PF07719.12 KOO21375.1 - 0.043 13.7 0.0 0.18 11.8 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOO21375.1 - 0.084 12.5 0.1 0.24 11.0 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Pkinase PF00069.20 KOO21376.1 - 5.7e-50 169.8 0.0 7.3e-50 169.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21376.1 - 1.4e-20 73.4 0.0 2.1e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase ATP-synt_Eps PF04627.8 KOO21376.1 - 4.9e-17 61.2 0.5 8.7e-17 60.4 0.3 1.4 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain Kinase-like PF14531.1 KOO21376.1 - 0.0017 17.3 0.0 0.0037 16.2 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOO21376.1 - 0.022 13.8 0.0 0.048 12.7 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_1 PF00036.27 KOO21378.1 - 1.9e-08 33.0 0.6 0.0027 16.8 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO21378.1 - 8.1e-08 32.2 0.5 1.2e-07 31.7 0.4 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO21378.1 - 1e-07 31.1 0.1 0.0079 16.0 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO21378.1 - 9.7e-05 21.9 0.8 0.00057 19.4 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO21378.1 - 0.01 15.1 0.2 2.8 7.4 0.1 2.3 2 0 0 2 2 2 0 EF hand Methyltransf_24 PF13578.1 KOO21379.1 - 0.0048 17.7 0.0 0.01 16.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain TP2 PF01254.13 KOO21379.1 - 0.03 14.6 6.8 0.049 13.9 4.7 1.3 1 0 0 1 1 1 0 Nuclear transition protein 2 CS PF04969.11 KOO21380.1 - 1.1e-07 32.2 0.0 2e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 CS domain Myb_DNA-binding PF00249.26 KOO21381.1 - 4.9e-13 48.9 0.0 8.3e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO21381.1 - 4.4e-07 29.8 0.0 8.2e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Trypan_glycop PF00913.14 KOO21381.1 - 0.0016 17.4 8.3 0.003 16.5 5.8 1.4 1 0 0 1 1 1 1 Trypanosome variant surface glycoprotein (A-type) Alveol-reg_P311 PF11092.3 KOO21381.1 - 0.041 13.8 0.1 0.12 12.3 0.1 1.8 1 0 0 1 1 1 0 Neuronal protein 3.1 (p311) TB2_DP1_HVA22 PF03134.14 KOO21382.1 - 1.6e-23 82.2 5.3 1.6e-23 82.2 3.7 1.5 2 0 0 2 2 2 1 TB2/DP1, HVA22 family Ribosomal_60s PF00428.14 KOO21382.1 - 0.03 14.7 3.8 0.043 14.2 2.6 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein zf-H2C2 PF09337.5 KOO21383.1 - 0.15 11.4 0.6 0.35 10.3 0.5 1.6 1 0 0 1 1 1 0 His(2)-Cys(2) zinc finger EF-hand_6 PF13405.1 KOO21384.1 - 0.0027 17.4 0.0 0.0097 15.7 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 KOO21384.1 - 0.014 15.5 0.2 0.093 12.8 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.27 KOO21384.1 - 0.017 14.3 0.0 0.044 13.1 0.0 1.8 1 0 0 1 1 1 0 EF hand EF-hand_5 PF13202.1 KOO21384.1 - 0.031 13.6 0.0 0.072 12.4 0.0 1.7 1 0 0 1 1 1 0 EF hand Exo_endo_phos PF03372.18 KOO21386.1 - 1.4e-09 38.2 0.0 1.8e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TPR_11 PF13414.1 KOO21387.1 - 4.5e-12 45.4 3.9 4.5e-12 45.4 2.7 2.3 2 0 0 2 2 2 1 TPR repeat TPR_1 PF00515.23 KOO21387.1 - 3.2e-08 32.8 2.4 8.4e-06 25.1 0.3 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO21387.1 - 5.6e-08 32.1 5.4 7.6e-06 25.4 0.6 3.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO21387.1 - 5.9e-05 22.9 3.1 5.9e-05 22.9 2.1 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOO21387.1 - 9.4e-05 22.1 2.0 9.4e-05 22.1 1.4 2.6 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO21387.1 - 0.00024 21.6 5.2 0.00024 21.6 3.6 4.8 5 1 1 6 6 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO21387.1 - 0.0056 16.3 0.6 0.045 13.5 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO21387.1 - 0.009 16.1 0.1 0.13 12.5 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat zf-CXXC PF02008.15 KOO21387.1 - 0.0097 15.7 15.7 0.021 14.5 10.9 1.5 1 0 0 1 1 1 1 CXXC zinc finger domain TPR_19 PF14559.1 KOO21387.1 - 0.033 14.5 1.6 0.033 14.5 1.1 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat Apc3 PF12895.2 KOO21387.1 - 0.056 13.5 3.9 0.058 13.5 0.3 2.3 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Exo_endo_phos PF03372.18 KOO21389.1 - 7.2e-20 71.9 0.1 1e-19 71.5 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PH_11 PF15413.1 KOO21389.1 - 0.1 12.8 4.6 0.094 12.9 2.0 1.8 1 1 0 1 1 1 0 Pleckstrin homology domain DUF572 PF04502.8 KOO21389.1 - 3.6 6.7 24.5 5.5 6.1 17.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) ACT PF01842.20 KOO21390.1 - 1.5e-14 53.1 2.7 1.3e-07 30.9 0.0 2.4 2 0 0 2 2 2 2 ACT domain ACT_4 PF13291.1 KOO21390.1 - 5.6e-07 29.8 0.7 0.044 14.1 0.0 2.4 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.1 KOO21390.1 - 0.00056 19.3 0.4 0.28 10.7 0.0 2.6 2 0 0 2 2 2 2 ACT domain ACT_6 PF13740.1 KOO21390.1 - 0.017 14.8 0.8 0.2 11.3 0.0 2.4 2 0 0 2 2 2 0 ACT domain UvrD-helicase PF00580.16 KOO21390.1 - 0.018 14.3 0.0 0.027 13.7 0.0 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Pkinase PF00069.20 KOO21391.1 - 8.3e-68 228.3 0.0 1.4e-66 224.2 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21391.1 - 2.7e-35 121.7 0.0 1e-33 116.5 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO21391.1 - 2.6e-05 23.3 0.0 3.6e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOO21391.1 - 0.00023 20.3 0.0 0.00038 19.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 KOO21391.1 - 0.14 11.4 0.0 0.44 9.8 0.0 1.8 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL DUF964 PF06133.6 KOO21392.1 - 0.046 13.7 2.3 0.056 13.4 1.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF964) SRP-alpha_N PF04086.8 KOO21392.1 - 0.05 12.9 1.1 0.052 12.9 0.8 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF1690 PF07956.6 KOO21392.1 - 0.14 12.1 2.7 0.17 11.8 1.9 1.1 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) DUF2795 PF11387.3 KOO21392.1 - 0.22 11.4 0.9 12 5.8 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2795) ERM PF00769.14 KOO21392.1 - 0.28 10.6 8.2 0.29 10.6 5.7 1.0 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Clusterin PF01093.12 KOO21392.1 - 0.36 9.5 3.5 0.38 9.5 2.4 1.1 1 0 0 1 1 1 0 Clusterin Histone_HNS PF00816.16 KOO21392.1 - 0.57 10.7 3.7 0.79 10.2 2.6 1.3 1 0 0 1 1 1 0 H-NS histone family DUF3395 PF11875.3 KOO21392.1 - 0.86 9.2 3.7 0.93 9.1 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3395) Ribosomal_L10 PF00466.15 KOO21392.1 - 1.2 9.1 5.2 9.5 6.2 0.1 2.8 1 1 2 3 3 3 0 Ribosomal protein L10 DUF4413 PF14372.1 KOO21393.1 - 0.0063 16.4 0.1 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4413) G6B PF15096.1 KOO21393.1 - 0.08 12.4 0.0 0.093 12.2 0.0 1.2 1 0 0 1 1 1 0 G6B family 3HCDH_N PF02737.13 KOO21394.1 - 4.2e-26 91.7 0.0 5.7e-26 91.2 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain zf-C3HC4_3 PF13920.1 KOO21394.1 - 4.5e-14 51.8 6.6 1e-13 50.7 4.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO21394.1 - 8.6e-08 32.0 8.4 2.6e-07 30.5 5.8 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO21394.1 - 2.4e-05 23.9 5.0 2.6e-05 23.7 2.1 2.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO21394.1 - 0.00016 21.3 5.3 0.00037 20.1 3.7 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 KOO21394.1 - 0.00084 19.1 7.5 0.00084 19.1 5.2 2.1 2 0 0 2 2 2 1 Ring finger domain NAD_binding_2 PF03446.10 KOO21394.1 - 0.013 15.3 0.0 0.023 14.5 0.0 1.4 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase GHMP_kinases_N PF00288.21 KOO21395.1 - 6.4e-09 35.7 0.2 2.1e-08 34.0 0.0 2.0 2 0 0 2 2 2 1 GHMP kinases N terminal domain NTP_transferase PF00483.18 KOO21395.1 - 6.3e-07 28.9 0.0 2e-06 27.2 0.0 1.7 2 0 0 2 2 2 1 Nucleotidyl transferase GalKase_gal_bdg PF10509.4 KOO21395.1 - 0.02 14.1 0.0 0.059 12.6 0.0 1.7 1 0 0 1 1 1 0 Galactokinase galactose-binding signature Spc7 PF08317.6 KOO21397.1 - 0.012 14.2 9.6 0.013 14.1 6.6 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein Harakiri PF15196.1 KOO21397.1 - 0.073 13.3 2.0 2 8.7 0.1 2.2 2 0 0 2 2 2 0 Activator of apoptosis harakiri MCC-bdg_PDZ PF10506.4 KOO21397.1 - 0.19 11.5 6.5 4.7 7.1 0.2 3.1 1 1 1 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome YkyA PF10368.4 KOO21397.1 - 0.2 10.9 4.0 0.32 10.3 2.8 1.4 1 1 0 1 1 1 0 Putative cell-wall binding lipoprotein DUF4208 PF13907.1 KOO21397.1 - 0.22 11.7 2.3 0.39 10.9 1.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4208) DUF641 PF04859.7 KOO21397.1 - 0.26 11.0 7.1 0.52 10.0 5.0 1.5 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) Laminin_II PF06009.7 KOO21397.1 - 0.26 11.0 5.5 0.38 10.4 3.8 1.3 1 0 0 1 1 1 0 Laminin Domain II DUF3422 PF11902.3 KOO21397.1 - 0.29 9.9 11.3 0.33 9.7 3.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3422) Phage_GP20 PF06810.6 KOO21397.1 - 0.32 10.4 5.8 0.13 11.7 1.8 1.8 1 1 1 2 2 2 0 Phage minor structural protein GP20 LXG PF04740.7 KOO21397.1 - 0.49 10.1 4.4 3 7.5 0.5 2.0 1 1 1 2 2 2 0 LXG domain of WXG superfamily HAUS-augmin3 PF14932.1 KOO21397.1 - 0.54 9.4 10.3 0.66 9.1 7.1 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF3584 PF12128.3 KOO21397.1 - 0.6 7.3 15.5 0.68 7.1 10.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Prefoldin_2 PF01920.15 KOO21397.1 - 0.63 9.8 10.5 1.1 9.0 1.4 2.2 1 1 0 2 2 2 0 Prefoldin subunit Viral_P18 PF04521.8 KOO21397.1 - 1.6 8.2 11.8 1.3 8.4 1.1 2.1 2 0 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein IncA PF04156.9 KOO21397.1 - 2 7.9 18.4 42 3.6 12.7 2.0 1 1 0 1 1 1 0 IncA protein TMF_DNA_bd PF12329.3 KOO21397.1 - 2.8 7.8 8.8 0.22 11.3 1.3 2.3 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding APG6 PF04111.7 KOO21397.1 - 3.2 6.7 10.9 4.3 6.2 7.6 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 YlqD PF11068.3 KOO21397.1 - 5.7 6.9 12.4 16 5.5 8.6 1.8 1 1 0 1 1 1 0 YlqD protein Vir_act_alpha_C PF10400.4 KOO21397.1 - 5.9 7.3 13.8 1.6 9.1 3.6 2.5 1 1 1 2 2 2 0 Virulence activator alpha C-term DUF972 PF06156.8 KOO21397.1 - 7 7.0 9.8 2.7 8.3 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Fzo_mitofusin PF04799.8 KOO21397.1 - 8.5 5.7 11.1 8.2 5.7 2.1 2.0 1 1 1 2 2 2 0 fzo-like conserved region Fib_alpha PF08702.5 KOO21397.1 - 8.9 6.4 7.2 2.6 8.1 1.4 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Leu_zip PF15294.1 KOO21398.1 - 4.3e-21 75.2 6.9 6.7e-21 74.6 4.8 1.3 1 0 0 1 1 1 1 Leucine zipper LRR_6 PF13516.1 KOO21398.1 - 1.6e-08 33.7 0.7 0.025 14.6 0.0 4.3 4 0 0 4 4 4 2 Leucine Rich repeat LRR_4 PF12799.2 KOO21398.1 - 0.01 15.4 2.4 2.2 8.0 0.4 3.3 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) HALZ PF02183.13 KOO21398.1 - 0.034 13.8 5.4 2.3 7.9 0.2 2.9 1 1 1 2 2 2 0 Homeobox associated leucine zipper DUF4407 PF14362.1 KOO21398.1 - 0.12 11.3 9.9 0.34 9.8 6.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LRR_1 PF00560.28 KOO21398.1 - 0.14 12.2 0.4 11 6.5 0.0 3.3 2 2 0 2 2 2 0 Leucine Rich Repeat BAG PF02179.11 KOO21398.1 - 0.22 11.6 4.6 2.5 8.2 0.2 2.8 2 0 0 2 2 2 0 BAG domain Seryl_tRNA_N PF02403.17 KOO21398.1 - 0.3 11.1 11.8 0.054 13.5 2.2 3.0 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain ALMT PF11744.3 KOO21398.1 - 0.52 8.9 3.2 1.5 7.3 2.2 1.8 1 1 0 1 1 1 0 Aluminium activated malate transporter Dynamitin PF04912.9 KOO21398.1 - 0.93 8.2 10.3 3.4 6.3 2.5 2.4 2 0 0 2 2 2 0 Dynamitin DUF972 PF06156.8 KOO21398.1 - 1.2 9.4 8.8 0.059 13.7 1.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF972) TPR_MLP1_2 PF07926.7 KOO21398.1 - 1.4 8.7 17.0 2.4 7.9 0.3 3.5 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein HAUS6_N PF14661.1 KOO21398.1 - 4.2 6.6 10.2 2.8 7.2 5.4 1.9 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Methyltransf_11 PF08241.7 KOO21399.1 - 8.2e-07 29.4 0.0 8.8e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO21399.1 - 1.2e-06 28.1 0.0 1.2e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO21399.1 - 1.3e-06 27.6 0.0 1.3e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.1 KOO21399.1 - 4.8e-05 23.1 0.0 4.9e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO21399.1 - 5.7e-05 23.5 0.0 6.6e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO21399.1 - 0.0034 17.9 0.0 0.0038 17.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO21399.1 - 0.029 14.7 0.0 0.03 14.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Brix PF04427.13 KOO21402.1 - 3.9e-43 147.3 0.0 5e-43 147.0 0.0 1.1 1 0 0 1 1 1 1 Brix domain TTL PF03133.10 KOO21403.1 - 9.7e-76 254.4 0.0 1.4e-75 253.9 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 KOO21403.1 - 0.00045 19.1 0.4 0.099 11.4 0.0 2.8 3 1 0 3 3 3 2 YheC/D like ATP-grasp ATP-grasp_3 PF02655.9 KOO21403.1 - 0.0037 17.1 0.0 0.016 15.0 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain Mg_trans_NIPA PF05653.9 KOO21406.1 - 3.1e-18 65.7 6.1 4.9e-18 65.1 4.3 1.3 1 1 0 1 1 1 1 Magnesium transporter NIPA VRR_NUC PF08774.6 KOO21407.1 - 3.1e-06 27.1 0.0 4.8e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 VRR-NUC domain Toxin_55 PF15606.1 KOO21407.1 - 0.042 13.8 0.0 0.078 12.9 0.0 1.5 1 1 0 1 1 1 0 Putative toxin 55 EF-hand_5 PF13202.1 KOO21408.1 - 2.8e-05 23.2 0.3 4.7e-05 22.5 0.2 1.4 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 KOO21408.1 - 3.6e-05 23.3 0.2 5.8e-05 22.6 0.2 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO21408.1 - 4e-05 22.6 1.3 4.7e-05 22.4 0.2 1.6 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO21408.1 - 8.7e-05 22.0 0.2 0.00019 21.0 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 KOO21408.1 - 0.035 14.2 0.0 0.057 13.5 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair TPR_10 PF13374.1 KOO21409.1 - 5.7e-80 261.2 51.0 3.7e-12 45.7 0.7 10.0 10 0 0 10 10 9 9 Tetratricopeptide repeat TPR_12 PF13424.1 KOO21409.1 - 2.5e-69 229.2 24.8 2.2e-18 65.9 1.2 6.2 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.23 KOO21409.1 - 1.4e-28 97.3 12.0 0.0012 18.3 0.0 8.6 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.12 KOO21409.1 - 1.5e-23 80.7 20.3 0.0036 17.1 0.4 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_11 PF13414.1 KOO21409.1 - 4.2e-22 77.5 7.2 2e-05 24.1 0.2 4.9 4 1 0 4 4 4 4 TPR repeat TPR_8 PF13181.1 KOO21409.1 - 2.6e-19 67.4 6.0 0.2 11.5 0.1 8.7 9 0 0 9 9 8 6 Tetratricopeptide repeat TPR_17 PF13431.1 KOO21409.1 - 1.1e-16 59.5 9.1 0.76 10.1 0.0 9.1 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_4 PF07721.9 KOO21409.1 - 1.5e-15 55.9 39.1 0.089 13.2 0.1 11.7 11 0 0 11 11 10 6 Tetratricopeptide repeat TPR_7 PF13176.1 KOO21409.1 - 6.6e-14 50.5 34.5 0.063 13.1 0.0 9.7 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_16 PF13432.1 KOO21409.1 - 1.1e-13 51.3 48.0 4.4e-07 30.3 3.0 7.9 6 1 3 9 9 7 5 Tetratricopeptide repeat TPR_19 PF14559.1 KOO21409.1 - 2.5e-08 34.1 27.5 0.00034 20.8 1.3 6.7 3 2 3 6 6 6 5 Tetratricopeptide repeat TPR_3 PF07720.7 KOO21409.1 - 3.2e-06 26.7 0.0 27 4.6 0.0 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat Osmo_CC PF08946.5 KOO21409.1 - 0.0013 18.7 2.6 8.8 6.4 0.0 5.5 5 0 0 5 5 5 1 Osmosensory transporter coiled coil Prok-TraM PF09228.5 KOO21409.1 - 0.01 15.9 0.5 0.067 13.3 0.2 2.4 2 0 0 2 2 2 0 Prokaryotic Transcriptional repressor TraM TPR_14 PF13428.1 KOO21409.1 - 0.018 15.6 57.8 2.5 8.9 0.3 10.7 8 3 3 11 11 9 0 Tetratricopeptide repeat zf-Nse PF11789.3 KOO21410.1 - 6.6e-05 22.3 2.7 0.00021 20.7 1.9 1.8 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-MIZ PF02891.15 KOO21410.1 - 0.13 11.7 4.6 0.18 11.3 2.7 1.7 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger Pectate_lyase_3 PF12708.2 KOO21412.1 - 0.0052 16.9 0.3 0.0064 16.6 0.2 1.1 1 0 0 1 1 1 1 Pectate lyase superfamily protein Phage_lysis PF03245.8 KOO21412.1 - 0.1 12.6 0.9 0.14 12.1 0.6 1.2 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein GCR1_C PF12550.3 KOO21413.1 - 5.8e-06 26.0 0.0 1.2e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes ABC1 PF03109.11 KOO21415.1 - 1.1e-25 89.8 0.0 2.1e-25 89.0 0.0 1.5 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 KOO21415.1 - 3.6e-05 23.5 0.4 0.0001 22.1 0.2 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family AGTRAP PF06396.6 KOO21416.1 - 0.13 11.9 0.9 0.19 11.4 0.2 1.5 1 1 0 1 1 1 0 Angiotensin II, type I receptor-associated protein (AGTRAP) CitMHS PF03600.11 KOO21417.1 - 7.1e-20 70.8 19.4 3.2e-14 52.2 0.0 3.0 1 1 1 3 3 3 3 Citrate transporter Na_sulph_symp PF00939.14 KOO21417.1 - 1.6e-09 37.2 28.2 3e-06 26.3 10.2 2.2 2 0 0 2 2 2 2 Sodium:sulfate symporter transmembrane region PDZ PF00595.19 KOO21419.1 - 2e-09 37.4 0.0 3.6e-09 36.6 0.0 1.5 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO21419.1 - 3.5e-07 30.0 0.0 4.2e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 PDZ domain LRR_5 PF13306.1 KOO21420.1 - 7.3e-91 300.5 0.3 6.2e-35 119.7 0.1 3.0 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO21420.1 - 4.7e-36 122.3 5.1 1.8e-07 30.7 0.0 6.5 1 1 8 9 9 9 9 Leucine rich repeat Fork_head_N PF08430.7 KOO21420.1 - 0.12 12.7 19.8 13 6.1 6.5 3.4 1 1 2 3 3 3 0 Forkhead N-terminal region Sulfatase PF00884.18 KOO21421.1 - 1.7e-34 119.3 0.0 2.4e-34 118.9 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.17 KOO21421.1 - 0.041 13.2 0.0 0.058 12.7 0.0 1.3 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase GAF_3 PF13492.1 KOO21424.1 - 0.0026 17.8 0.0 0.0053 16.8 0.0 1.4 1 0 0 1 1 1 1 GAF domain BAH PF01426.13 KOO21425.1 - 1.5e-14 53.8 0.0 2.4e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 BAH domain AAA PF00004.24 KOO21425.1 - 1.3e-13 51.3 0.0 3.2e-13 50.0 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO21425.1 - 4.4e-11 43.1 2.5 6.7e-11 42.5 0.2 2.4 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 KOO21425.1 - 6.9e-10 39.1 0.1 2.2e-09 37.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 KOO21425.1 - 0.00022 20.9 0.0 0.00045 19.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_19 PF13245.1 KOO21425.1 - 0.00034 20.2 2.8 0.0013 18.3 0.1 3.1 3 0 0 3 3 3 1 Part of AAA domain Arch_ATPase PF01637.13 KOO21425.1 - 0.00057 19.6 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 Archaeal ATPase DUF2075 PF09848.4 KOO21425.1 - 0.071 12.0 0.0 0.15 11.0 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.1 KOO21425.1 - 0.099 12.1 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 KOO21425.1 - 0.1 12.2 0.1 0.28 10.8 0.1 1.9 1 1 0 1 1 1 0 NTPase AAA_32 PF13654.1 KOO21425.1 - 0.11 11.1 0.0 0.2 10.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain DEAD PF00270.24 KOO21425.1 - 0.17 11.3 0.4 2 7.8 0.3 2.1 1 1 0 1 1 1 0 DEAD/DEAH box helicase ABM PF03992.11 KOO21427.1 - 4.9e-14 52.1 0.7 3.9e-06 26.7 0.1 2.2 2 0 0 2 2 2 2 Antibiotic biosynthesis monooxygenase CRAL_TRIO PF00650.15 KOO21428.1 - 1e-08 34.8 0.0 1.5e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain Ank_2 PF12796.2 KOO21430.1 - 1.7e-36 124.4 17.0 1.8e-14 53.8 2.2 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO21430.1 - 4.7e-21 73.4 17.1 2.6e-06 26.9 0.1 5.8 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.1 KOO21430.1 - 2.5e-20 72.0 10.6 2.4e-09 37.1 0.4 4.5 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO21430.1 - 3e-20 72.1 1.0 9.1e-07 29.2 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeats (many copies) zf-C3HC4_3 PF13920.1 KOO21430.1 - 1.8e-11 43.5 8.7 3.2e-11 42.7 6.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Ank_3 PF13606.1 KOO21430.1 - 2.7e-11 42.5 4.2 0.0056 16.7 0.0 5.7 5 0 0 5 5 5 3 Ankyrin repeat Prok-RING_4 PF14447.1 KOO21430.1 - 0.0089 15.5 6.5 0.019 14.4 4.5 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.1 KOO21430.1 - 0.04 13.9 12.0 0.073 13.1 8.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO21430.1 - 0.14 11.8 10.2 0.35 10.6 7.1 1.7 1 1 0 1 1 1 0 zinc-RING finger domain SURF4 PF02077.10 KOO21431.1 - 1.1e-31 110.2 4.6 1.5e-31 109.8 3.2 1.1 1 0 0 1 1 1 1 SURF4 family Ank_2 PF12796.2 KOO21432.1 - 1e-12 48.2 0.9 5.3e-12 45.9 0.6 2.3 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO21432.1 - 7.5e-12 45.4 0.1 1.7e-07 31.5 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO21432.1 - 2.2e-10 40.4 0.7 2.1e-05 24.5 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO21432.1 - 3.8e-10 39.0 7.9 7.9e-07 28.5 0.1 3.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.1 KOO21432.1 - 1.7e-07 30.7 0.0 0.021 15.0 0.0 3.3 2 0 0 2 2 2 2 Ankyrin repeat DUF61 PF01886.11 KOO21432.1 - 0.089 12.6 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF61 ParcG PF10274.4 KOO21433.1 - 1.6e-33 116.1 0.0 5.2e-28 98.1 0.0 2.6 2 0 0 2 2 2 2 Parkin co-regulated protein Ribosomal_L29 PF00831.18 KOO21433.1 - 4.1e-20 71.2 3.4 4.1e-20 71.2 2.3 3.1 3 0 0 3 3 3 1 Ribosomal L29 protein DUF3829 PF12889.2 KOO21433.1 - 0.48 9.5 7.2 0.063 12.4 1.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3829) DUF4208 PF13907.1 KOO21433.1 - 4.8 7.4 8.2 3.7 7.8 0.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4208) Peptidase_M14 PF00246.19 KOO21434.1 - 1.5e-23 83.8 0.0 2.3e-23 83.2 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase Pentapeptide PF00805.17 KOO21434.1 - 0.0015 17.7 0.1 0.2 10.9 0.0 2.4 2 0 0 2 2 2 2 Pentapeptide repeats (8 copies) AstE_AspA PF04952.9 KOO21434.1 - 0.1 11.4 0.1 0.15 10.9 0.1 1.2 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family BTAD PF03704.12 KOO21435.1 - 0.0086 16.3 7.5 0.0086 16.3 5.2 2.1 1 1 1 2 2 2 1 Bacterial transcriptional activator domain Cep57_CLD PF14073.1 KOO21435.1 - 0.011 15.6 12.1 0.026 14.3 8.3 1.7 1 1 1 2 2 2 0 Centrosome localisation domain of Cep57 MAD PF05557.8 KOO21435.1 - 0.025 12.6 13.0 0.032 12.3 9.0 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein Viral_P18 PF04521.8 KOO21435.1 - 0.05 13.0 0.6 0.05 13.0 0.4 2.1 1 1 2 3 3 3 0 ssRNA positive strand viral 18kD cysteine rich protein Baculo_PEP_C PF04513.7 KOO21435.1 - 0.079 12.7 1.4 0.54 10.0 0.3 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus RBD-FIP PF09457.5 KOO21435.1 - 0.097 12.4 0.4 0.097 12.4 0.3 2.9 3 0 0 3 3 3 0 FIP domain IncA PF04156.9 KOO21435.1 - 0.1 12.2 15.1 2.2 7.8 9.0 2.2 1 1 1 2 2 2 0 IncA protein Syntaxin-6_N PF09177.6 KOO21435.1 - 0.27 11.6 8.1 0.13 12.6 1.5 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Rootletin PF15035.1 KOO21435.1 - 0.3 11.0 15.2 0.86 9.5 10.6 1.6 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion BLOC1_2 PF10046.4 KOO21435.1 - 0.33 11.1 2.6 12 6.1 0.1 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.7 KOO21435.1 - 0.44 10.2 5.7 0.15 11.7 0.5 2.0 1 1 1 2 2 2 0 Laminin Domain II FUSC PF04632.7 KOO21435.1 - 0.89 7.9 12.3 3.5 5.9 8.5 1.8 1 1 0 1 1 1 0 Fusaric acid resistance protein family CorA PF01544.13 KOO21435.1 - 3.1 6.7 4.5 3.9 6.4 2.8 1.4 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein Fib_alpha PF08702.5 KOO21435.1 - 5.1 7.1 9.9 6.5 6.8 4.1 2.2 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family APG6 PF04111.7 KOO21435.1 - 8.3 5.3 10.9 4.8 6.1 4.2 1.8 1 1 1 2 2 2 0 Autophagy protein Apg6 SlyX PF04102.7 KOO21435.1 - 8.7 6.8 17.4 4 7.8 0.1 3.9 1 1 1 3 3 3 0 SlyX DSPc PF00782.15 KOO21436.1 - 1.6e-30 105.4 0.0 2.3e-30 104.8 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KOO21436.1 - 8.7e-05 21.9 0.0 0.00015 21.2 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase LRR_4 PF12799.2 KOO21437.1 - 2.6e-08 33.2 4.7 0.0085 15.6 0.0 4.4 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO21437.1 - 1.5e-05 24.6 3.7 0.043 13.5 0.1 3.2 1 1 3 4 4 4 4 Leucine rich repeat LRR_7 PF13504.1 KOO21437.1 - 0.0028 17.5 7.2 8.3 7.1 0.1 5.7 5 0 0 5 5 5 1 Leucine rich repeat LRR_1 PF00560.28 KOO21437.1 - 0.015 15.1 7.2 18 5.8 0.1 4.6 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_9 PF14580.1 KOO21437.1 - 0.39 10.2 1.4 0.82 9.2 0.3 1.8 1 1 0 2 2 2 0 Leucine-rich repeat Peptidase_C65 PF10275.4 KOO21438.1 - 2.5e-12 46.6 0.0 3.9e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain WSC PF01822.14 KOO21438.1 - 2.1e-11 43.6 4.2 4.5e-11 42.5 2.9 1.6 1 0 0 1 1 1 1 WSC domain fn3 PF00041.16 KOO21438.1 - 8.1e-08 32.2 0.0 3.1e-06 27.2 0.0 3.3 2 1 0 2 2 2 1 Fibronectin type III domain Ribosomal_L18e PF00828.14 KOO21439.1 - 7.5e-19 68.3 0.0 1.2e-18 67.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 Bunya_G2 PF03563.8 KOO21439.1 - 0.065 12.1 0.0 0.091 11.6 0.0 1.1 1 0 0 1 1 1 0 Bunyavirus glycoprotein G2 PI3_PI4_kinase PF00454.22 KOO21440.1 - 2.2e-11 43.7 0.0 7.6e-06 25.5 0.0 2.3 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PH PF00169.24 KOO21441.1 - 0.0083 16.3 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_4 PF15404.1 KOO21441.1 - 0.16 11.4 0.0 0.25 10.8 0.0 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain AAA_12 PF13087.1 KOO21442.1 - 4.6e-46 156.7 0.0 6.9e-46 156.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 KOO21442.1 - 1.2e-29 103.5 0.0 1.2e-13 51.2 0.0 2.7 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.1 KOO21442.1 - 5e-13 49.0 0.0 2.6e-12 46.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOO21442.1 - 6.1e-10 38.7 0.1 3.1e-09 36.4 0.1 2.2 2 0 0 2 2 2 1 Part of AAA domain PhoH PF02562.11 KOO21442.1 - 4.3e-05 22.8 0.0 0.029 13.5 0.0 2.3 2 0 0 2 2 2 2 PhoH-like protein ResIII PF04851.10 KOO21442.1 - 5.9e-05 22.9 0.0 0.00016 21.5 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 KOO21442.1 - 0.00021 21.4 0.0 0.00076 19.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain DEAD PF00270.24 KOO21442.1 - 0.00037 20.0 0.0 0.00092 18.7 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase DUF3410 PF11890.3 KOO21442.1 - 0.00088 18.8 0.0 0.0025 17.4 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3410) UvrD_C PF13361.1 KOO21442.1 - 0.0026 17.2 0.0 0.033 13.6 0.0 2.2 1 1 1 2 2 2 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.16 KOO21442.1 - 0.0035 16.7 0.0 0.012 14.9 0.0 1.8 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain FtsK_SpoIIIE PF01580.13 KOO21442.1 - 0.025 14.0 0.0 0.69 9.3 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family T2SE PF00437.15 KOO21442.1 - 0.032 13.1 0.0 0.056 12.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_28 PF13521.1 KOO21442.1 - 0.034 14.0 0.2 1.2 9.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.1 KOO21442.1 - 0.037 13.4 0.0 0.08 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Helicase_RecD PF05127.9 KOO21442.1 - 0.038 13.6 0.0 0.1 12.2 0.0 1.8 1 1 0 1 1 1 0 Helicase AAA PF00004.24 KOO21442.1 - 0.047 13.8 1.1 0.17 12.0 0.7 1.9 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.13 KOO21442.1 - 0.061 12.8 0.1 14 5.0 0.1 3.2 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase SRP54 PF00448.17 KOO21442.1 - 0.08 12.3 0.0 0.21 10.9 0.0 1.7 2 0 0 2 2 1 0 SRP54-type protein, GTPase domain PIF1 PF05970.9 KOO21442.1 - 0.083 11.8 0.0 6 5.7 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase AAA_24 PF13479.1 KOO21442.1 - 0.09 12.3 0.1 0.22 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 KOO21442.1 - 0.094 13.5 0.1 0.27 12.0 0.1 1.8 1 0 0 1 1 1 0 AAA domain IL4Ra_N PF09238.5 KOO21442.1 - 0.18 11.9 0.0 0.37 10.9 0.0 1.4 1 0 0 1 1 1 0 Interleukin-4 receptor alpha chain, N-terminal RNA_helicase PF00910.17 KOO21442.1 - 0.22 11.7 0.0 0.46 10.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase CBFD_NFYB_HMF PF00808.18 KOO21443.1 - 5.4e-09 35.9 0.0 9.7e-09 35.1 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone zf-CXXC PF02008.15 KOO21443.1 - 1.1e-07 31.5 21.1 2.6e-07 30.3 14.6 1.7 1 1 0 1 1 1 1 CXXC zinc finger domain Myosin_head PF00063.16 KOO21444.1 - 3.2e-186 620.4 0.0 4e-186 620.0 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Zeta_toxin PF06414.7 KOO21444.1 - 0.0087 15.1 0.0 0.019 14.0 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.1 KOO21444.1 - 0.046 13.8 0.0 0.22 11.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 KOO21444.1 - 0.07 13.1 0.0 0.49 10.3 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain GAD PF02938.9 KOO21444.1 - 0.61 10.2 6.2 3.7 7.7 0.2 3.3 3 0 0 3 3 3 0 GAD domain EF-hand_1 PF00036.27 KOO21445.1 - 3.8e-11 41.4 1.7 0.00021 20.3 0.6 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO21445.1 - 8.1e-09 35.4 0.3 1.5e-08 34.6 0.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO21445.1 - 1.7e-08 33.6 2.1 0.00023 20.7 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO21445.1 - 9.8e-07 28.2 0.9 5.4e-06 25.9 0.2 2.1 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO21445.1 - 6.8e-06 25.1 0.9 0.071 12.4 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.2 KOO21445.1 - 0.00041 20.0 0.4 0.00091 18.9 0.3 1.6 1 1 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand FAM183 PF14886.1 KOO21446.1 - 0.0034 17.8 0.0 0.0055 17.2 0.0 1.3 1 0 0 1 1 1 1 FAM183A and FAM183B related EF-hand_6 PF13405.1 KOO21446.1 - 0.049 13.5 0.0 12 6.0 0.0 2.6 2 1 0 2 2 2 0 EF-hand domain Lsr2 PF11774.3 KOO21448.1 - 0.07 13.0 0.2 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 Lsr2 FlgN PF05130.7 KOO21448.1 - 0.11 12.7 1.7 0.56 10.4 0.1 2.2 1 1 1 2 2 2 0 FlgN protein Peptidase_M16 PF00675.15 KOO21449.1 - 3.3e-40 137.2 0.1 2.6e-39 134.3 0.0 2.3 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 KOO21449.1 - 4.3e-35 121.0 0.0 1e-18 67.6 0.0 3.0 3 0 0 3 3 3 2 Peptidase M16 inactive domain ZZ PF00569.12 KOO21449.1 - 0.2 11.2 0.1 0.46 10.0 0.1 1.6 1 0 0 1 1 1 0 Zinc finger, ZZ type UPF0029 PF01205.14 KOO21450.1 - 4.6e-15 55.2 0.1 7.8e-15 54.5 0.1 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 Thioredoxin PF00085.15 KOO21451.1 - 0.00043 19.9 0.0 0.021 14.5 0.0 2.8 2 1 1 3 3 3 2 Thioredoxin cNMP_binding PF00027.24 KOO21452.1 - 1.1e-17 63.5 0.0 2e-08 33.9 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain SET PF00856.23 KOO21453.1 - 0.043 14.1 0.1 11 6.2 0.0 3.0 2 1 0 2 2 2 0 SET domain RNase_T PF00929.19 KOO21454.1 - 2.5e-22 79.9 0.0 3e-22 79.6 0.0 1.1 1 0 0 1 1 1 1 Exonuclease Ras PF00071.17 KOO21455.1 - 1.2e-36 125.5 0.0 1.5e-36 125.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO21455.1 - 1.9e-14 54.1 0.0 2.4e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO21455.1 - 4.1e-12 45.6 0.0 4.8e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 KOO21455.1 - 0.0017 17.8 0.0 0.035 13.5 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MoeA_N PF03453.12 KOO21455.1 - 0.0025 17.1 0.0 0.0041 16.4 0.0 1.3 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) ATP-synt_ab PF00006.20 KOO21455.1 - 0.022 14.2 0.0 5.8 6.3 0.0 2.1 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_22 PF13401.1 KOO21455.1 - 0.11 12.5 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain Ax_dynein_light PF10211.4 KOO21456.1 - 4.2e-07 29.9 8.4 1e-06 28.7 4.8 2.2 2 1 0 2 2 2 1 Axonemal dynein light chain EF-hand_1 PF00036.27 KOO21456.1 - 0.00048 19.2 1.3 0.00082 18.5 0.2 2.0 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO21456.1 - 0.00069 19.7 0.3 0.0026 17.8 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO21456.1 - 0.0019 17.9 1.5 0.024 14.4 0.2 3.2 2 1 1 3 3 3 1 EF-hand domain EF-hand_8 PF13833.1 KOO21456.1 - 0.0059 16.1 0.1 0.017 14.7 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO21456.1 - 0.01 15.1 0.8 0.025 13.9 0.6 1.7 1 0 0 1 1 1 0 EF hand YukD PF08817.5 KOO21456.1 - 0.027 15.0 0.3 0.12 12.9 0.2 2.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD Sybindin PF04099.7 KOO21457.1 - 6.8e-27 93.9 0.1 7.3e-27 93.8 0.0 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.8 KOO21457.1 - 3.4e-10 39.9 0.0 3.8e-10 39.7 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region YTH PF04146.10 KOO21458.1 - 1.5e-44 150.9 0.0 2e-44 150.6 0.0 1.1 1 0 0 1 1 1 1 YT521-B-like domain MFS_1 PF07690.11 KOO21459.1 - 1e-15 57.3 21.1 1e-15 57.3 14.6 2.3 1 1 1 2 2 2 1 Major Facilitator Superfamily LRR_5 PF13306.1 KOO21463.1 - 7.9e-08 32.0 0.0 9.4e-08 31.8 0.0 1.0 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) zf-RING_2 PF13639.1 KOO21464.1 - 1.6e-14 53.4 9.3 2.1e-14 53.0 6.5 1.2 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KOO21464.1 - 8.4e-09 35.4 7.2 1.3e-08 34.8 5.0 1.4 1 1 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 KOO21464.1 - 1.2e-08 34.7 9.4 1.7e-08 34.3 6.5 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO21464.1 - 3.8e-08 32.8 6.4 5.3e-08 32.4 4.5 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO21464.1 - 4e-08 32.7 9.4 5.3e-08 32.3 6.5 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO21464.1 - 1.6e-07 30.9 8.3 2.1e-07 30.5 5.7 1.2 1 0 0 1 1 1 1 zinc-RING finger domain RINGv PF12906.2 KOO21464.1 - 0.0031 17.5 6.3 0.0066 16.4 4.4 1.5 1 1 0 1 1 1 1 RING-variant domain zf-Apc11 PF12861.2 KOO21464.1 - 0.0088 15.8 7.0 0.017 14.9 4.8 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.3 KOO21464.1 - 0.02 14.8 9.1 0.15 12.0 6.3 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.1 KOO21464.1 - 0.078 12.5 8.3 0.13 11.8 5.8 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain YdjO PF14169.1 KOO21464.1 - 0.11 11.9 2.4 0.97 8.9 0.1 2.2 2 0 0 2 2 2 0 Cold-inducible protein YdjO zf-RING_UBOX PF13445.1 KOO21464.1 - 0.44 10.3 6.9 0.77 9.5 4.8 1.4 1 0 0 1 1 1 0 RING-type zinc-finger PHD PF00628.24 KOO21464.1 - 3.6 7.3 10.0 6.5 6.5 6.9 1.5 1 0 0 1 1 1 0 PHD-finger Ribosomal_S13 PF00416.17 KOO21465.1 - 1.9e-20 73.2 0.0 2.5e-20 72.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S13/S18 PPPI_inhib PF14895.1 KOO21467.1 - 4.8e-14 51.8 2.5 5.4e-11 41.8 0.4 2.6 2 1 0 2 2 2 2 Protein phosphatase 1 inhibitor Pkinase PF00069.20 KOO21468.1 - 3.2e-64 216.5 0.0 4.5e-64 216.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21468.1 - 2.9e-27 95.3 0.0 4e-27 94.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.24 KOO21468.1 - 1.6e-12 47.5 0.0 3.1e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 PH domain Pkinase_C PF00433.19 KOO21468.1 - 3.4e-07 30.6 0.4 6.5e-07 29.7 0.3 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 KOO21468.1 - 4.6e-07 29.0 0.0 6.5e-06 25.3 0.0 2.2 2 0 0 2 2 2 1 Kinase-like PH_11 PF15413.1 KOO21468.1 - 1.2e-06 28.7 0.1 5.5e-06 26.6 0.0 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.1 KOO21468.1 - 0.00084 19.4 0.0 0.0026 17.8 0.0 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain F_bP_aldolase PF01116.15 KOO21470.1 - 1.2e-95 319.8 0.0 1.4e-95 319.6 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II MR_MLE_C PF13378.1 KOO21470.1 - 0.078 12.9 0.0 0.24 11.4 0.0 1.8 1 0 0 1 1 1 0 Enolase C-terminal domain-like DUF4326 PF14216.1 KOO21471.1 - 2.4e-05 24.7 0.9 0.0017 18.9 0.1 3.0 2 1 0 2 2 2 1 Domain of unknown function (DUF4326) RVT_1 PF00078.22 KOO21471.1 - 0.00031 20.1 0.0 0.00066 19.0 0.0 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.1 KOO21473.1 - 0.049 13.2 0.0 0.096 12.3 0.0 1.6 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase COesterase PF00135.23 KOO21474.1 - 1.5e-59 202.1 0.0 1.8e-59 201.8 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 KOO21474.1 - 6.1e-09 35.7 7.6 0.0003 20.4 0.0 3.8 3 1 0 4 4 4 2 alpha/beta hydrolase fold Rod_cone_degen PF15201.1 KOO21474.1 - 0.13 12.1 0.2 0.3 10.9 0.1 1.6 1 0 0 1 1 1 0 Progressive rod-cone degeneration adh_short PF00106.20 KOO21475.1 - 1.1e-28 100.2 3.0 1.5e-28 99.8 2.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KOO21475.1 - 2.1e-28 99.7 0.1 2.4e-28 99.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KOO21475.1 - 1.2e-12 47.9 2.0 1.7e-12 47.3 1.4 1.2 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.14 KOO21475.1 - 5.8e-05 21.9 1.1 6.9e-05 21.6 0.8 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 KOO21475.1 - 0.00053 18.9 0.3 0.00088 18.2 0.2 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.16 KOO21475.1 - 0.0012 18.3 0.7 0.0023 17.4 0.5 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Pyr_redox PF00070.22 KOO21475.1 - 0.0022 18.3 0.2 0.0059 16.9 0.2 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.1 KOO21475.1 - 0.017 15.3 0.2 0.028 14.6 0.2 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.13 KOO21475.1 - 0.024 14.3 0.3 0.037 13.6 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.14 KOO21475.1 - 0.045 12.8 0.0 0.069 12.2 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TauD PF02668.11 KOO21476.1 - 3.6e-15 56.3 0.1 1.1e-10 41.6 0.0 3.5 2 2 0 2 2 2 2 Taurine catabolism dioxygenase TauD, TfdA family PAS PF00989.19 KOO21477.1 - 0.0061 16.3 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 PAS fold Myosin_head PF00063.16 KOO21478.1 - 5.2e-173 576.7 0.0 7.1e-173 576.3 0.0 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_22 PF13401.1 KOO21478.1 - 0.0011 19.1 0.1 0.038 14.1 0.0 3.0 3 0 0 3 3 3 1 AAA domain TrwB_AAD_bind PF10412.4 KOO21478.1 - 0.0081 14.8 0.0 0.017 13.7 0.0 1.4 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain Zeta_toxin PF06414.7 KOO21478.1 - 0.033 13.3 0.0 0.033 13.3 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin AAA_19 PF13245.1 KOO21478.1 - 0.11 12.2 0.0 0.44 10.3 0.0 2.0 1 0 0 1 1 1 0 Part of AAA domain DUF605 PF04652.11 KOO21479.1 - 1.5e-48 166.1 1.9 5.4e-39 134.6 0.2 2.0 1 1 1 2 2 2 2 Vta1 like Mtp PF03821.11 KOO21480.1 - 0.052 12.9 0.4 0.059 12.7 0.3 1.1 1 0 0 1 1 1 0 Golgi 4-transmembrane spanning transporter TFIIA PF03153.8 KOO21481.1 - 0.4 10.5 1.8 0.43 10.4 1.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit LRR_6 PF13516.1 KOO21482.1 - 2.4e-17 60.9 18.1 0.018 15.0 0.2 10.3 10 0 0 10 10 10 6 Leucine Rich repeat LRR_4 PF12799.2 KOO21482.1 - 6.2e-11 41.6 0.1 0.04 13.5 0.0 6.1 5 1 0 5 5 5 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO21482.1 - 0.00015 21.2 4.0 27 5.3 0.0 7.0 9 0 0 9 9 9 0 Leucine Rich Repeat LRR_8 PF13855.1 KOO21482.1 - 0.00046 19.8 4.6 0.68 9.7 0.0 5.1 3 2 2 5 5 5 1 Leucine rich repeat MobB PF03205.9 KOO21482.1 - 0.025 14.2 0.0 0.047 13.3 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B LRR_7 PF13504.1 KOO21482.1 - 0.032 14.3 12.0 1e+02 3.7 0.0 8.5 10 0 0 10 10 10 0 Leucine rich repeat AAA_33 PF13671.1 KOO21482.1 - 0.056 13.3 0.4 17 5.2 0.1 3.0 3 0 0 3 3 3 0 AAA domain ATP_bind_1 PF03029.12 KOO21482.1 - 0.2 11.1 0.5 0.37 10.2 0.4 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein zf-DHHC PF01529.15 KOO21483.1 - 2.6e-41 140.9 8.5 2.6e-41 140.9 5.9 1.5 2 0 0 2 2 2 1 DHHC palmitoyltransferase LRR_6 PF13516.1 KOO21484.1 - 2.8e-26 88.5 10.2 0.022 14.7 0.0 8.4 9 0 0 9 9 9 7 Leucine Rich repeat LRR_4 PF12799.2 KOO21484.1 - 1e-11 44.1 0.0 0.012 15.1 0.0 4.6 3 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO21484.1 - 3.7e-06 26.6 1.9 0.29 10.9 0.2 4.4 3 1 1 4 4 4 3 Leucine rich repeat LRR_1 PF00560.28 KOO21484.1 - 0.00014 21.4 0.0 76 3.9 0.0 6.6 8 0 0 8 8 8 0 Leucine Rich Repeat Reo_sigmaC PF04582.7 KOO21484.1 - 0.13 11.4 7.9 0.35 10.0 0.6 3.2 1 1 2 3 3 3 0 Reovirus sigma C capsid protein IFT57 PF10498.4 KOO21484.1 - 0.46 9.1 12.7 0.087 11.5 3.9 2.2 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Fib_alpha PF08702.5 KOO21484.1 - 1.8 8.6 5.3 1.8 8.6 0.3 2.9 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family KxDL PF10241.4 KOO21484.1 - 2.5 8.0 9.5 0.29 11.0 1.6 3.1 2 2 2 4 4 4 0 Uncharacterized conserved protein RIH_assoc PF08454.6 KOO21485.1 - 2.2e-21 75.5 0.9 2.2e-21 75.5 0.6 2.9 3 0 0 3 3 3 1 RyR and IP3R Homology associated Ins145_P3_rec PF08709.6 KOO21485.1 - 1.7e-20 73.0 0.0 3.4e-19 68.7 0.0 2.4 1 1 0 1 1 1 1 Inositol 1,4,5-trisphosphate/ryanodine receptor Ion_trans PF00520.26 KOO21485.1 - 2.2e-06 27.0 8.2 5.3e-06 25.8 5.7 1.6 1 0 0 1 1 1 1 Ion transport protein CN_hydrolase PF00795.17 KOO21486.1 - 4.7e-23 81.5 0.0 7.1e-23 80.9 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase ATP-grasp_4 PF13535.1 KOO21487.1 - 2.1e-17 63.4 0.0 5.1e-17 62.1 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_3 PF02655.9 KOO21487.1 - 0.0014 18.5 0.0 0.0027 17.5 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 KOO21487.1 - 0.0037 16.0 0.0 0.0069 15.1 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon APC10 PF03256.11 KOO21489.1 - 4.1e-45 153.7 0.1 4.9e-45 153.4 0.0 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) PITH PF06201.8 KOO21489.1 - 0.015 15.1 0.2 0.025 14.3 0.1 1.5 1 1 0 1 1 1 0 PITH domain PALP PF00291.20 KOO21490.1 - 1.4e-65 221.5 3.9 2e-65 221.0 2.7 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.13 KOO21490.1 - 8.2e-30 102.2 0.0 4.7e-18 64.5 0.0 2.5 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase Acetyltransf_11 PF13720.1 KOO21490.1 - 0.11 12.7 0.0 0.34 11.1 0.0 1.8 1 0 0 1 1 1 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Thioredoxin_8 PF13905.1 KOO21492.1 - 4.7e-11 42.6 0.0 5.4e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 KOO21492.1 - 0.046 13.9 0.0 0.052 13.7 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin-like domain Mg_trans_NIPA PF05653.9 KOO21493.1 - 1e-17 64.0 8.5 2.4e-09 36.6 0.5 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA Multi_Drug_Res PF00893.14 KOO21493.1 - 0.042 14.3 1.4 0.042 14.3 0.9 3.0 2 1 0 2 2 2 0 Small Multidrug Resistance protein Ion_trans PF00520.26 KOO21494.1 - 4e-10 39.2 9.0 4e-10 39.2 4.2 2.2 2 0 0 2 2 2 1 Ion transport protein Ion_trans_N PF08412.5 KOO21494.1 - 0.0013 17.9 0.0 0.0035 16.6 0.0 1.7 1 0 0 1 1 1 1 Ion transport protein N-terminal cNMP_binding PF00027.24 KOO21494.1 - 0.04 13.7 0.0 0.12 12.2 0.0 1.7 2 0 0 2 2 2 0 Cyclic nucleotide-binding domain Spc24 PF08286.6 KOO21495.1 - 3.8e-07 29.8 1.7 3.8e-07 29.8 1.1 2.0 1 1 1 2 2 2 1 Spc24 subunit of Ndc80 V_ATPase_I PF01496.14 KOO21495.1 - 0.035 11.9 1.9 0.041 11.7 1.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.6 KOO21495.1 - 0.048 12.3 6.9 0.064 11.9 4.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF2130 PF09903.4 KOO21495.1 - 0.053 12.2 6.4 0.072 11.8 4.4 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2130) HALZ PF02183.13 KOO21495.1 - 0.057 13.1 0.2 0.15 11.7 0.1 1.7 1 1 0 1 1 1 0 Homeobox associated leucine zipper Ycf4 PF02392.11 KOO21495.1 - 0.11 11.7 0.3 0.21 10.9 0.2 1.4 1 0 0 1 1 1 0 Ycf4 EIAV_Rev PF11129.3 KOO21495.1 - 0.13 12.2 0.6 0.43 10.5 0.0 1.8 1 1 1 2 2 2 0 Rev protein of equine infectious anaemia virus PRCC PF10253.4 KOO21495.1 - 0.26 11.9 5.0 0.35 11.5 3.5 1.2 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Sec34 PF04136.10 KOO21495.1 - 0.27 10.9 2.7 1 9.0 1.9 1.8 1 1 0 1 1 1 0 Sec34-like family APG6 PF04111.7 KOO21495.1 - 0.32 10.0 6.6 0.45 9.5 4.6 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 bZIP_2 PF07716.10 KOO21495.1 - 0.85 9.4 6.7 5.2 6.9 0.3 2.9 2 1 0 2 2 2 0 Basic region leucine zipper Syntaxin-6_N PF09177.6 KOO21495.1 - 1 9.8 8.1 2.8 8.4 4.8 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal UPF0242 PF06785.6 KOO21495.1 - 1.1 7.8 5.5 1.4 7.4 3.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) Ax_dynein_light PF10211.4 KOO21495.1 - 1.2 8.9 10.2 0.38 10.5 4.8 1.7 1 1 1 2 2 2 0 Axonemal dynein light chain Jnk-SapK_ap_N PF09744.4 KOO21495.1 - 2.2 8.2 7.3 5.3 7.0 5.1 1.6 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 ADIP PF11559.3 KOO21495.1 - 2.8 7.8 15.2 6.8 6.5 8.4 2.3 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF972 PF06156.8 KOO21495.1 - 3.7 7.9 7.9 1.8 8.9 2.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) IncA PF04156.9 KOO21495.1 - 4 6.9 10.5 7.4 6.1 3.3 2.1 1 1 0 2 2 2 0 IncA protein DUF948 PF06103.6 KOO21495.1 - 6.1 6.7 6.7 14 5.6 0.9 2.4 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Syntaxin PF00804.20 KOO21495.1 - 7.3 6.8 12.6 2.4 8.3 5.6 2.1 1 1 1 2 2 2 0 Syntaxin Glyco_transf_8 PF01501.15 KOO21496.1 - 4.2e-10 39.3 0.0 2.8e-09 36.6 0.0 2.3 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mito_carr PF00153.22 KOO21497.1 - 3.1e-35 119.7 0.9 1.2e-20 73.0 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF1336 PF07059.7 KOO21499.1 - 2.4e-45 154.7 0.0 3.4e-45 154.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1336) SKG6 PF08693.5 KOO21499.1 - 0.0076 15.5 5.3 0.016 14.5 3.7 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain PP2C PF00481.16 KOO21500.1 - 3.7e-38 131.3 0.0 5e-38 130.9 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 KOO21500.1 - 1.8e-06 27.5 1.5 2.5e-06 27.0 0.0 2.0 2 1 0 2 2 2 1 Protein phosphatase 2C PEMT PF04191.8 KOO21501.1 - 2.7e-09 37.0 0.2 2.7e-09 37.0 0.1 3.4 3 0 0 3 3 3 1 Phospholipid methyltransferase DUF962 PF06127.6 KOO21501.1 - 4.1 7.3 11.5 0.62 9.9 2.9 3.2 2 2 0 2 2 2 0 Protein of unknown function (DUF962) GTP_EFTU PF00009.22 KOO21503.1 - 1.2e-48 165.0 0.0 1.7e-48 164.5 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.19 KOO21503.1 - 3.2e-19 68.5 0.0 7e-19 67.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.1 KOO21503.1 - 0.0019 18.0 0.0 0.0046 16.7 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II Mito_carr PF00153.22 KOO21504.1 - 2.1e-12 46.5 4.1 5e-12 45.3 0.0 3.0 3 0 0 3 3 3 1 Mitochondrial carrier protein Helicase_C PF00271.26 KOO21504.1 - 5.7e-07 29.3 0.0 1.2e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF2116 PF09889.4 KOO21504.1 - 0.06 13.1 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) HNH PF01844.18 KOO21504.1 - 0.076 12.9 0.1 0.71 9.7 0.0 2.3 2 0 0 2 2 2 0 HNH endonuclease Helicase_C_4 PF13871.1 KOO21504.1 - 0.08 12.3 0.5 0.15 11.4 0.3 1.4 1 0 0 1 1 1 0 Helicase_C-like DUF329 PF03884.9 KOO21504.1 - 0.14 11.7 0.6 0.35 10.4 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF329) DUF3752 PF12572.3 KOO21505.1 - 3.1 7.9 8.2 1.3 9.0 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3752) DUF900 PF05990.7 KOO21506.1 - 1.3e-16 60.6 0.0 1.8e-12 47.1 0.0 2.2 2 0 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF900) CKS PF01111.14 KOO21506.1 - 0.083 12.7 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Cyclin-dependent kinase regulatory subunit DivIC PF04977.10 KOO21507.1 - 0.013 15.0 2.4 9.3 5.8 0.0 3.3 3 0 0 3 3 3 0 Septum formation initiator HALZ PF02183.13 KOO21507.1 - 0.41 10.3 6.4 0.96 9.2 0.0 2.9 3 0 0 3 3 3 0 Homeobox associated leucine zipper DNA_methylase PF00145.12 KOO21508.1 - 2.8e-53 181.1 0.0 3.5e-53 180.8 0.0 1.1 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase Methyltransf_26 PF13659.1 KOO21508.1 - 0.0035 17.3 0.5 0.009 16.0 0.4 1.7 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 KOO21508.1 - 0.17 11.4 0.0 0.27 10.7 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein PsbP PF01789.11 KOO21509.1 - 3.1e-07 29.9 0.1 0.00034 20.0 0.0 2.1 2 0 0 2 2 2 2 PsbP tRNA_bind PF01588.15 KOO21510.1 - 9.2e-28 95.9 0.0 1.5e-27 95.2 0.0 1.3 1 0 0 1 1 1 1 Putative tRNA binding domain Myosin_head PF00063.16 KOO21511.1 - 5.7e-168 560.0 1.3 5.1e-130 434.6 0.0 3.1 2 1 1 3 3 3 2 Myosin head (motor domain) Tub PF01167.13 KOO21511.1 - 1.4e-35 122.5 0.0 2.8e-35 121.4 0.0 1.5 1 0 0 1 1 1 1 Tub family DUF3527 PF12043.3 KOO21511.1 - 0.0018 17.8 0.0 0.0018 17.8 0.0 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF3527) AAA_22 PF13401.1 KOO21511.1 - 0.0051 16.9 0.0 0.033 14.3 0.0 2.5 1 0 0 1 1 1 1 AAA domain WW PF00397.21 KOO21511.1 - 0.011 15.5 0.1 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 WW domain IQ PF00612.22 KOO21511.1 - 0.11 12.1 1.2 0.36 10.6 0.9 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif Ycf1 PF05758.7 KOO21511.1 - 0.15 9.7 6.8 0.23 9.1 4.7 1.2 1 0 0 1 1 1 0 Ycf1 DUF572 PF04502.8 KOO21511.1 - 5.1 6.2 25.4 9.4 5.3 17.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) EF-hand_6 PF13405.1 KOO21512.1 - 1.5e-21 74.2 7.5 1e-06 28.1 0.0 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.27 KOO21512.1 - 2.6e-21 73.2 6.9 2.5e-06 26.4 0.0 5.4 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.1 KOO21512.1 - 2e-19 69.5 2.6 1e-12 47.9 0.3 3.5 3 1 2 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO21512.1 - 7.8e-17 59.7 7.1 5e-06 25.6 0.1 4.8 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO21512.1 - 1.1e-15 56.9 9.0 2.2e-09 36.7 0.8 3.8 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_9 PF14658.1 KOO21512.1 - 4.2e-05 23.3 0.1 0.0019 18.0 0.0 3.0 3 0 0 3 3 3 1 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO21512.1 - 0.00026 20.9 1.9 0.06 13.3 0.8 3.3 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region COG6 PF06419.6 KOO21512.1 - 0.13 10.3 8.5 0.27 9.3 5.9 1.4 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 APG6 PF04111.7 KOO21512.1 - 0.5 9.3 17.6 0.091 11.7 9.7 1.7 2 0 0 2 2 2 0 Autophagy protein Apg6 V_ATPase_I PF01496.14 KOO21512.1 - 7.4 4.2 8.2 13 3.5 5.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Sel1 PF08238.7 KOO21514.1 - 5.5e-13 49.0 8.8 2.2e-06 28.1 0.8 3.6 3 0 0 3 3 3 3 Sel1 repeat U-box PF04564.10 KOO21514.1 - 1.9e-11 43.7 0.0 3.3e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO21514.1 - 0.00036 20.0 0.0 0.00065 19.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Methyltransf_16 PF10294.4 KOO21515.1 - 4.3e-05 23.0 0.0 5.8e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase ATP-synt_ab PF00006.20 KOO21518.1 - 2e-56 190.9 0.0 2.6e-56 190.5 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 KOO21518.1 - 9.2e-17 61.5 0.0 2e-16 60.4 0.0 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 KOO21518.1 - 6.1e-11 42.3 0.7 1.3e-10 41.2 0.5 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Ank_2 PF12796.2 KOO21520.1 - 1.8e-19 69.8 0.1 1.3e-10 41.4 0.0 3.9 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO21520.1 - 4.8e-15 55.2 1.3 0.0016 18.6 0.0 4.9 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO21520.1 - 1.4e-14 54.1 2.0 0.00028 21.2 0.0 5.2 3 1 3 6 6 6 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO21520.1 - 3.1e-14 51.9 0.3 0.0001 21.9 0.0 6.2 6 0 0 6 6 6 2 Ankyrin repeat Ion_trans PF00520.26 KOO21520.1 - 8.4e-10 38.2 0.0 1.6e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Ion transport protein Ank_3 PF13606.1 KOO21520.1 - 1.3e-07 31.1 0.0 0.38 11.1 0.0 5.0 5 0 0 5 5 5 2 Ankyrin repeat DUF3584 PF12128.3 KOO21520.1 - 0.081 10.2 5.5 0.11 9.7 3.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Apolipoprotein PF01442.13 KOO21520.1 - 0.093 12.2 9.0 0.18 11.2 6.2 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.7 KOO21520.1 - 0.34 10.7 3.3 0.35 10.6 1.3 1.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus OmpH PF03938.9 KOO21520.1 - 7.8 6.4 10.9 22 4.9 7.6 1.7 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) CAP_GLY PF01302.20 KOO21521.1 - 1.1e-19 69.8 1.4 1.1e-19 69.8 1.0 1.7 2 0 0 2 2 2 1 CAP-Gly domain Arm PF00514.18 KOO21522.1 - 6.4e-08 32.1 0.1 0.0043 16.8 0.0 2.2 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO21522.1 - 0.017 15.4 0.5 0.025 14.8 0.3 1.5 1 1 0 1 1 1 0 HEAT repeats HEAT PF02985.17 KOO21522.1 - 0.083 13.0 0.1 0.84 9.8 0.0 2.2 1 1 1 2 2 2 0 HEAT repeat Ribosomal_L7Ae PF01248.21 KOO21523.1 - 4.5e-05 22.8 0.8 2.8 7.4 0.0 5.1 3 2 3 6 6 6 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family FeoA PF04023.9 KOO21523.1 - 6.2e-05 22.8 5.7 14 5.7 0.0 6.1 7 0 0 7 7 7 1 FeoA domain CENP-H PF05837.7 KOO21523.1 - 0.00048 20.2 0.7 0.93 9.7 0.1 4.0 2 2 3 5 5 5 1 Centromere protein H (CENP-H) Metallophos_2 PF12850.2 KOO21523.1 - 0.00054 19.8 0.0 16 5.2 0.0 4.0 1 1 2 4 4 4 1 Calcineurin-like phosphoesterase superfamily domain Hpr_kinase_N PF02603.11 KOO21523.1 - 0.0068 16.0 0.4 5.9 6.6 0.0 4.0 2 2 3 5 5 5 1 HPr Serine kinase N terminus UMPH-1 PF05822.7 KOO21523.1 - 0.055 12.7 0.0 76 2.4 0.0 4.3 2 2 3 6 6 6 0 Pyrimidine 5'-nucleotidase (UMPH-1) NICE-3 PF07406.6 KOO21523.1 - 0.089 12.2 13.4 3.9 6.9 0.1 5.3 3 2 3 6 6 6 0 NICE-3 protein Sel1 PF08238.7 KOO21524.1 - 3.8e-38 129.0 39.1 4.4e-09 36.6 0.7 6.3 7 0 0 7 7 7 5 Sel1 repeat Metallophos_C PF14008.1 KOO21525.1 - 8.2e-08 32.2 0.3 2.3e-07 30.8 0.0 2.0 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C Metallophos PF00149.23 KOO21525.1 - 1e-06 28.3 0.8 5.2e-05 22.7 0.0 2.2 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase PhoD PF09423.5 KOO21525.1 - 4.2e-06 25.6 0.0 7.9e-06 24.6 0.0 1.4 1 0 0 1 1 1 1 PhoD-like phosphatase Zeta_toxin PF06414.7 KOO21526.1 - 1.3e-16 60.3 0.0 5.4e-16 58.2 0.0 1.9 1 1 1 2 2 2 1 Zeta toxin AAA_33 PF13671.1 KOO21526.1 - 2.4e-05 24.2 0.0 6.2e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 AAA domain MFS_1 PF07690.11 KOO21527.1 - 1.8e-21 76.2 28.7 2.1e-15 56.2 13.4 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 KOO21527.1 - 9.4e-05 21.1 9.2 0.019 13.5 3.3 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_2 PF13347.1 KOO21527.1 - 0.0027 16.1 8.1 0.18 10.1 0.1 2.4 2 1 0 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.2 KOO21527.1 - 0.0057 16.4 0.3 0.042 13.6 0.0 2.3 2 0 0 2 2 2 1 MFS_1 like family Kinesin PF00225.18 KOO21528.1 - 6.1e-37 127.0 0.0 1.7e-36 125.5 0.0 1.7 1 1 0 1 1 1 1 Kinesin motor domain Bac_DnaA PF00308.13 KOO21528.1 - 0.072 12.7 0.1 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein Kinesin PF00225.18 KOO21529.1 - 1.1e-84 284.0 0.0 1.5e-84 283.5 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Homeobox PF00046.24 KOO21529.1 - 9.6e-05 21.9 0.0 0.00019 20.9 0.0 1.5 1 0 0 1 1 1 1 Homeobox domain Peptidase_S9 PF00326.16 KOO21530.1 - 3.2e-47 160.5 0.0 4.9e-47 159.9 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.10 KOO21530.1 - 2.1e-14 52.9 0.0 1.7e-10 40.1 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase, N-terminal beta-propeller domain Abhydrolase_5 PF12695.2 KOO21530.1 - 0.0017 18.1 0.1 0.0089 15.7 0.0 2.2 2 1 1 3 3 3 1 Alpha/beta hydrolase family NDUFA12 PF05071.11 KOO21531.1 - 8.7e-19 67.9 1.9 1.4e-18 67.2 1.3 1.4 1 1 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 LRR_6 PF13516.1 KOO21532.1 - 5.4e-20 69.1 13.1 0.00026 20.7 0.3 7.5 7 1 0 7 7 7 4 Leucine Rich repeat LRR_4 PF12799.2 KOO21532.1 - 0.0003 20.3 9.9 0.32 10.6 0.8 4.7 2 2 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO21532.1 - 0.00079 19.1 0.1 2e+02 2.6 0.0 5.8 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.1 KOO21532.1 - 0.14 11.9 6.3 3.1 7.6 2.0 4.3 3 1 1 4 4 4 0 Leucine rich repeat CbiG_N PF11760.3 KOO21532.1 - 0.17 11.5 9.5 8.3 6.1 0.2 4.2 2 1 2 4 4 4 0 Cobalamin synthesis G N-terminal LRR_7 PF13504.1 KOO21532.1 - 0.3 11.4 11.2 62 4.4 0.0 6.3 6 1 0 6 6 6 0 Leucine rich repeat HGTP_anticodon PF03129.15 KOO21533.1 - 6.5e-12 45.2 0.0 1.1e-11 44.5 0.0 1.4 1 1 0 1 1 1 1 Anticodon binding domain DPM3 PF08285.6 KOO21533.1 - 0.12 12.1 0.1 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Exonuc_VII_L PF02601.10 KOO21534.1 - 1.3 8.0 10.1 1.8 7.7 7.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit TIG PF01833.19 KOO21535.1 - 2.9e-64 213.0 30.8 6.1e-06 26.1 0.1 14.9 13 0 0 13 13 13 12 IPT/TIG domain PTCB-BRCT PF12738.2 KOO21535.1 - 0.00043 20.0 0.0 44 4.0 0.0 7.0 7 0 0 7 7 7 1 twin BRCT domain ATC_hydrolase PF14196.1 KOO21535.1 - 5.7 7.3 0.0 13 6.2 0.0 1.4 1 0 0 1 1 1 0 L-2-amino-thiazoline-4-carboxylic acid hydrolase tRNA-synt_2b PF00587.20 KOO21536.1 - 3.2e-15 56.1 0.0 4e-15 55.8 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Flt3_lig PF02947.9 KOO21537.1 - 6.7 6.6 0.0 14 5.5 0.0 1.5 1 0 0 1 1 1 0 flt3 ligand Trigger_N PF05697.8 KOO21537.1 - 7.5 6.3 0.1 1.4e+02 2.1 0.0 3.1 4 0 0 4 4 4 0 Bacterial trigger factor protein (TF) DNA_methylase PF00145.12 KOO21538.1 - 3.4e-09 36.3 0.0 4.6e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase PHD_2 PF13831.1 KOO21538.1 - 2.2e-07 30.0 5.5 2.2e-07 30.0 3.8 4.2 5 1 0 5 5 5 1 PHD-finger PHD PF00628.24 KOO21538.1 - 5.5e-06 25.9 8.2 5.5e-06 25.9 5.7 4.2 4 0 0 4 4 4 2 PHD-finger zf-HC5HC2H_2 PF13832.1 KOO21538.1 - 5.8e-05 23.0 4.7 5.8e-05 23.0 3.3 3.0 3 1 0 3 3 3 1 PHD-zinc-finger like domain Chorein_N PF12624.2 KOO21540.1 - 6e-25 87.0 0.0 1.2e-24 86.0 0.0 1.4 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter DER1 PF04511.10 KOO21541.1 - 6e-17 61.8 0.0 8.4e-17 61.3 0.0 1.2 1 0 0 1 1 1 1 Der1-like family RNA_pol_I_A49 PF06870.7 KOO21542.1 - 5.1e-27 94.4 0.0 7.5e-27 93.8 0.0 1.1 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor Rubis-subs-bind PF09273.6 KOO21542.1 - 3e-08 33.6 0.3 8.4e-08 32.1 0.2 1.7 2 0 0 2 2 2 1 Rubisco LSMT substrate-binding Thioredoxin PF00085.15 KOO21544.1 - 7e-12 44.9 0.0 1.2e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin APG6 PF04111.7 KOO21544.1 - 0.0083 15.2 0.2 0.0099 14.9 0.1 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 Thioredoxin_6 PF13848.1 KOO21544.1 - 0.0086 15.8 0.0 0.021 14.6 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain FimP PF09766.4 KOO21544.1 - 0.04 12.9 1.4 0.051 12.6 1.0 1.2 1 0 0 1 1 1 0 Fms-interacting protein IncA PF04156.9 KOO21544.1 - 0.083 12.4 1.0 0.098 12.2 0.7 1.1 1 0 0 1 1 1 0 IncA protein Peptidase_S24 PF00717.18 KOO21545.1 - 9.2e-08 31.6 0.0 3.3e-07 29.8 0.0 1.9 2 0 0 2 2 2 1 Peptidase S24-like Peptidase_S26 PF10502.4 KOO21545.1 - 2.1e-05 24.0 0.0 5e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Signal peptidase, peptidase S26 ABC_tran PF00005.22 KOO21547.1 - 4.5e-48 163.0 0.0 1.2e-25 90.3 0.0 2.8 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 KOO21547.1 - 2.8e-21 76.7 0.5 7.9e-06 26.0 0.0 4.2 3 1 0 4 4 4 4 AAA domain ABC_tran_2 PF12848.2 KOO21547.1 - 3.4e-15 55.6 4.4 3.4e-15 55.6 3.0 3.9 4 1 0 4 4 4 1 ABC transporter DUF258 PF03193.11 KOO21547.1 - 1.4e-08 34.0 0.2 1.7e-05 24.0 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 SMC_N PF02463.14 KOO21547.1 - 6.7e-08 32.0 0.7 0.0053 16.0 0.0 4.0 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 KOO21547.1 - 1.5e-07 32.2 1.2 0.0089 16.8 0.0 3.4 4 0 0 4 4 2 2 AAA domain AAA_22 PF13401.1 KOO21547.1 - 5.5e-07 29.7 2.1 0.01 15.9 0.0 3.4 3 1 0 3 3 2 2 AAA domain AAA_29 PF13555.1 KOO21547.1 - 2.5e-06 26.9 0.5 0.0057 16.1 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain Miro PF08477.8 KOO21547.1 - 8.3e-06 26.2 0.0 0.12 12.8 0.0 2.5 2 0 0 2 2 2 2 Miro-like protein AAA_18 PF13238.1 KOO21547.1 - 1.8e-05 25.0 1.4 0.78 10.0 0.0 3.8 3 0 0 3 3 3 2 AAA domain SbcCD_C PF13558.1 KOO21547.1 - 7.4e-05 22.5 0.0 0.0052 16.6 0.0 3.0 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.1 KOO21547.1 - 8.6e-05 22.0 3.3 0.058 12.7 0.0 3.6 4 0 0 4 4 4 2 AAA domain MMR_HSR1 PF01926.18 KOO21547.1 - 9e-05 22.4 0.0 0.061 13.2 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.7 KOO21547.1 - 0.00025 20.7 0.1 0.3 10.7 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_15 PF13175.1 KOO21547.1 - 0.00029 20.0 0.0 1.9 7.4 0.0 3.7 4 0 0 4 4 4 1 AAA ATPase domain MobB PF03205.9 KOO21547.1 - 0.00083 19.0 0.6 0.18 11.5 0.1 3.3 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B AAA PF00004.24 KOO21547.1 - 0.0011 19.1 5.1 0.094 12.9 0.0 3.4 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 KOO21547.1 - 0.0016 18.4 9.2 0.047 13.6 0.1 3.3 4 0 0 4 4 3 2 AAA domain AAA_23 PF13476.1 KOO21547.1 - 0.0018 18.6 10.7 0.13 12.5 0.0 3.4 2 1 1 3 3 3 2 AAA domain SRP54 PF00448.17 KOO21547.1 - 0.0019 17.6 1.3 0.15 11.5 0.2 2.7 2 1 0 2 2 2 1 SRP54-type protein, GTPase domain RNA_helicase PF00910.17 KOO21547.1 - 0.0041 17.2 0.0 0.74 10.0 0.0 2.4 2 0 0 2 2 2 1 RNA helicase AAA_33 PF13671.1 KOO21547.1 - 0.0042 16.9 2.8 1.3 8.8 0.0 3.4 3 0 0 3 3 3 1 AAA domain NTPase_1 PF03266.10 KOO21547.1 - 0.0046 16.6 0.2 0.72 9.5 0.0 2.6 2 0 0 2 2 2 1 NTPase AAA_14 PF13173.1 KOO21547.1 - 0.0053 16.6 0.0 2.5 7.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 KOO21547.1 - 0.014 15.0 0.9 2.9 7.6 0.1 2.9 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.17 KOO21547.1 - 0.015 14.2 0.1 1.7 7.4 0.1 2.4 2 0 0 2 2 2 0 NB-ARC domain Arch_ATPase PF01637.13 KOO21547.1 - 0.016 14.9 0.0 3.4 7.3 0.0 2.6 2 0 0 2 2 2 0 Archaeal ATPase PduV-EutP PF10662.4 KOO21547.1 - 0.021 14.2 0.0 9.9 5.6 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.1 KOO21547.1 - 0.033 13.7 3.2 6.8 6.2 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.1 KOO21547.1 - 0.053 13.5 14.4 0.44 10.5 0.3 3.9 4 1 0 4 4 4 0 AAA ATPase domain KAP_NTPase PF07693.9 KOO21547.1 - 0.077 11.9 0.0 6.7 5.5 0.0 2.5 2 0 0 2 2 2 0 KAP family P-loop domain AAA_10 PF12846.2 KOO21547.1 - 0.13 11.6 4.7 1.1 8.6 0.0 3.1 4 0 0 4 4 3 0 AAA-like domain Ras PF00071.17 KOO21547.1 - 0.15 11.4 0.1 17 4.7 0.0 2.4 2 0 0 2 2 2 0 Ras family ATP-synt_ab PF00006.20 KOO21547.1 - 0.19 11.2 0.0 1.5 8.2 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF904 PF06005.7 KOO21547.1 - 4.1 7.7 9.9 1.8 8.8 3.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF904) DUF3094 PF11293.3 KOO21548.1 - 0.15 11.5 1.0 0.31 10.5 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) DUF3814 PF12769.2 KOO21548.1 - 0.39 10.9 2.1 0.72 10.0 1.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3814) Tetraspannin PF00335.15 KOO21548.1 - 0.39 9.9 7.2 7.3 5.8 4.1 2.1 2 0 0 2 2 2 0 Tetraspanin family SAP PF02037.22 KOO21548.1 - 2.2 7.9 4.6 8.3 6.0 0.1 3.5 4 0 0 4 4 4 0 SAP domain MatE PF01554.13 KOO21549.1 - 7e-16 58.2 9.7 7e-16 58.2 6.8 3.6 4 0 0 4 4 4 2 MatE Polysacc_synt_C PF14667.1 KOO21549.1 - 3.7e-06 26.8 4.8 3.7e-06 26.8 3.3 4.9 3 3 3 6 6 6 1 Polysaccharide biosynthesis C-terminal domain AAA_2 PF07724.9 KOO21551.1 - 2.7e-48 164.1 0.0 1.5e-46 158.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 KOO21551.1 - 1.4e-23 83.5 0.0 1.6e-12 47.7 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KOO21551.1 - 1e-15 57.6 0.0 3.3e-10 39.8 0.0 3.3 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOO21551.1 - 1.5e-13 51.1 12.8 1.1e-05 25.5 0.0 5.5 3 3 1 5 5 4 3 AAA ATPase domain AAA_22 PF13401.1 KOO21551.1 - 2.2e-10 40.7 1.5 0.0011 19.1 0.0 4.7 3 2 0 3 3 3 2 AAA domain AAA_17 PF13207.1 KOO21551.1 - 4.6e-09 37.1 1.0 0.0054 17.5 0.0 3.8 3 1 0 3 3 3 2 AAA domain IstB_IS21 PF01695.12 KOO21551.1 - 1.1e-07 31.4 0.0 0.012 15.0 0.0 2.8 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_14 PF13173.1 KOO21551.1 - 1.6e-07 31.2 0.0 0.0021 17.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.21 KOO21551.1 - 1.6e-07 30.9 0.1 0.00023 20.6 0.0 2.9 3 0 0 3 3 2 2 Sigma-54 interaction domain AAA_18 PF13238.1 KOO21551.1 - 8.7e-07 29.2 0.0 0.032 14.5 0.0 3.0 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 KOO21551.1 - 1.3e-06 28.5 0.0 0.29 11.3 0.0 3.5 3 0 0 3 3 3 2 RNA helicase Mg_chelatase PF01078.16 KOO21551.1 - 1.5e-06 27.4 0.0 0.11 11.6 0.0 3.5 2 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 KOO21551.1 - 1.7e-06 27.6 0.0 0.045 13.5 0.0 3.0 2 0 0 2 2 2 2 Part of AAA domain Arch_ATPase PF01637.13 KOO21551.1 - 1.8e-06 27.8 0.3 0.62 9.7 0.0 3.9 2 2 1 3 3 3 2 Archaeal ATPase ClpB_D2-small PF10431.4 KOO21551.1 - 2.6e-06 27.2 0.0 8.6e-06 25.5 0.0 1.9 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein ABC_tran PF00005.22 KOO21551.1 - 3.9e-05 23.9 0.2 0.0069 16.6 0.0 3.2 3 0 0 3 3 3 1 ABC transporter MobB PF03205.9 KOO21551.1 - 6.9e-05 22.5 0.1 0.07 12.8 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Zeta_toxin PF06414.7 KOO21551.1 - 9e-05 21.6 0.0 0.012 14.7 0.0 2.7 2 0 0 2 2 2 1 Zeta toxin RuvB_N PF05496.7 KOO21551.1 - 0.0001 21.4 1.2 0.21 10.5 0.0 3.3 2 1 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 KOO21551.1 - 0.00011 22.0 1.4 0.065 13.1 0.0 3.6 3 0 0 3 3 3 1 AAA domain AAA_3 PF07726.6 KOO21551.1 - 0.00013 21.5 0.2 0.22 11.1 0.1 3.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.11 KOO21551.1 - 0.00015 20.9 0.0 0.2 10.8 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_25 PF13481.1 KOO21551.1 - 0.00022 20.6 4.1 0.13 11.6 0.1 3.4 3 1 0 3 3 3 2 AAA domain NACHT PF05729.7 KOO21551.1 - 0.00024 20.7 0.0 0.42 10.2 0.0 2.8 2 0 0 2 2 2 2 NACHT domain AAA_10 PF12846.2 KOO21551.1 - 0.00026 20.5 0.2 0.12 11.7 0.0 3.7 3 1 0 4 4 4 1 AAA-like domain UPF0079 PF02367.12 KOO21551.1 - 0.00042 19.9 0.0 0.14 11.8 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_23 PF13476.1 KOO21551.1 - 0.00043 20.6 1.8 0.049 13.9 0.0 2.8 3 0 0 3 3 3 1 AAA domain TniB PF05621.6 KOO21551.1 - 0.00043 19.1 0.0 0.0011 17.8 0.0 1.7 2 0 0 2 2 2 1 Bacterial TniB protein T2SE PF00437.15 KOO21551.1 - 0.00064 18.7 0.0 0.024 13.5 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein MMR_HSR1 PF01926.18 KOO21551.1 - 0.0019 18.1 0.0 1.8 8.5 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase NTPase_1 PF03266.10 KOO21551.1 - 0.002 17.8 0.1 2.3 7.8 0.0 2.8 3 0 0 3 3 2 1 NTPase SRP54 PF00448.17 KOO21551.1 - 0.0022 17.4 0.0 0.21 10.9 0.0 2.5 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_29 PF13555.1 KOO21551.1 - 0.0032 16.9 0.0 2.1 7.9 0.0 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF815 PF05673.8 KOO21551.1 - 0.0044 15.9 3.8 0.26 10.1 0.0 3.3 3 1 0 3 3 2 1 Protein of unknown function (DUF815) Miro PF08477.8 KOO21551.1 - 0.0044 17.5 0.0 3.2 8.2 0.0 2.5 2 0 0 2 2 2 0 Miro-like protein AAA_28 PF13521.1 KOO21551.1 - 0.0045 16.9 8.8 0.42 10.5 0.0 4.2 3 2 0 3 3 2 2 AAA domain AAA_24 PF13479.1 KOO21551.1 - 0.0051 16.4 0.0 0.78 9.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain ATP_bind_1 PF03029.12 KOO21551.1 - 0.0066 16.0 0.0 3.6 7.0 0.0 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein PduV-EutP PF10662.4 KOO21551.1 - 0.0066 15.9 0.0 0.14 11.6 0.0 2.4 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Torsin PF06309.6 KOO21551.1 - 0.0068 16.2 0.0 0.036 13.9 0.0 2.1 2 0 0 2 2 2 1 Torsin CbiA PF01656.18 KOO21551.1 - 0.027 13.8 0.2 6.8 6.0 0.1 2.5 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Ras PF00071.17 KOO21551.1 - 0.029 13.7 0.0 3.2 7.1 0.0 2.3 2 0 0 2 2 2 0 Ras family Bac_DnaA PF00308.13 KOO21551.1 - 0.055 13.0 0.0 5.2 6.6 0.0 2.6 2 0 0 2 2 2 0 Bacterial dnaA protein Borrelia_P83 PF05262.6 KOO21551.1 - 0.061 11.5 6.4 0.11 10.7 4.4 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein VirE PF05272.6 KOO21551.1 - 0.13 11.6 0.0 5.7 6.3 0.0 2.9 3 0 0 3 3 3 0 Virulence-associated protein E AAA_21 PF13304.1 KOO21551.1 - 0.29 11.0 0.0 36 4.1 0.0 2.9 3 0 0 3 3 3 0 AAA domain OEP PF02321.13 KOO21551.1 - 1.1 8.8 13.4 2.7 7.5 9.3 1.6 1 0 0 1 1 1 0 Outer membrane efflux protein V_ATPase_I PF01496.14 KOO21551.1 - 2.6 5.7 2.8 3.8 5.2 2.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peptidase_M16_C PF05193.16 KOO21553.1 - 1.5e-34 119.2 0.0 2.5e-34 118.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 KOO21553.1 - 1.5e-27 96.1 0.2 2.6e-27 95.3 0.1 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) HhH-GPD PF00730.20 KOO21554.1 - 1.1e-12 48.1 0.0 1.7e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 KOO21554.1 - 2.8e-07 29.8 0.0 5.1e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.1 KOO21554.1 - 0.012 15.7 0.0 0.025 14.7 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix domain Orn_Arg_deC_N PF02784.11 KOO21555.1 - 2.7e-59 200.4 0.0 4.7e-59 199.6 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.17 KOO21555.1 - 5.4e-24 84.1 0.0 1.2e-23 83.0 0.0 1.6 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain CMD PF02627.15 KOO21555.1 - 0.021 14.6 0.0 0.062 13.1 0.0 1.8 1 0 0 1 1 1 0 Carboxymuconolactone decarboxylase family HTH_30 PF13556.1 KOO21555.1 - 0.11 12.0 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain EXS PF03124.9 KOO21556.1 - 1.3e-66 225.0 3.4 1.3e-66 225.0 2.3 1.5 2 0 0 2 2 2 1 EXS family PARP PF00644.15 KOO21557.1 - 1.4e-15 57.2 0.0 5.2e-15 55.4 0.0 1.9 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain AAA_11 PF13086.1 KOO21558.1 - 3.1e-17 62.9 0.1 3.5e-09 36.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 KOO21558.1 - 4.4e-05 23.1 0.0 0.00018 21.1 0.0 2.1 1 0 0 1 1 1 1 Part of AAA domain AAA_12 PF13087.1 KOO21558.1 - 7.4e-05 22.2 0.0 0.00013 21.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC_ATPase PF09818.4 KOO21559.1 - 1.9e-57 194.8 0.0 2.9e-44 151.4 0.0 2.1 1 1 1 2 2 2 2 Predicted ATPase of the ABC class Pkinase_Tyr PF07714.12 KOO21559.1 - 1.9e-07 30.4 0.0 3.1e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 KOO21559.1 - 1e-06 28.1 0.0 1.5e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PQ-loop PF04193.9 KOO21560.1 - 1.2e-08 34.3 0.3 2.7e-08 33.2 0.0 1.7 2 0 0 2 2 2 1 PQ loop repeat DUF164 PF02591.10 KOO21560.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Putative zinc ribbon domain DUF4235 PF14019.1 KOO21561.1 - 0.026 14.3 2.4 0.061 13.1 1.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4235) EF-hand_6 PF13405.1 KOO21562.1 - 3.2e-25 85.6 4.6 6e-05 22.6 0.0 6.7 6 1 0 6 6 6 5 EF-hand domain EF-hand_1 PF00036.27 KOO21562.1 - 2.3e-24 82.7 2.4 1.3e-05 24.1 0.1 6.5 5 1 1 6 6 6 3 EF hand EF-hand_7 PF13499.1 KOO21562.1 - 5.4e-20 71.3 0.5 0.00058 19.9 0.0 5.7 5 1 0 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO21562.1 - 2.5e-16 58.1 8.3 0.0003 19.9 0.0 6.3 7 0 0 7 7 7 3 EF hand EF-hand_8 PF13833.1 KOO21562.1 - 3.1e-16 58.7 10.8 0.00022 20.7 0.0 6.0 4 2 2 6 6 6 5 EF-hand domain pair DUF4473 PF14747.1 KOO21562.1 - 5.4e-06 26.5 0.0 0.0057 16.8 0.0 2.8 3 0 0 3 3 3 2 Domain of unknown function (DUF4473) SPARC_Ca_bdg PF10591.4 KOO21562.1 - 0.00082 19.3 0.3 1.9 8.5 0.0 4.2 3 2 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region Endonuc-dimeris PF09124.5 KOO21562.1 - 0.0063 16.1 0.0 15 5.3 0.0 4.0 4 0 0 4 4 4 0 T4 recombination endonuclease VII, dimerisation EF-hand_4 PF12763.2 KOO21562.1 - 0.022 14.4 7.8 1.5 8.5 0.0 4.6 3 2 2 5 5 5 0 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO21562.1 - 0.038 13.9 1.3 1.2e+02 2.6 0.0 4.9 7 0 0 7 7 7 0 EF-hand domain DUF2428 PF10350.4 KOO21562.1 - 0.089 11.8 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) CdCA1 PF10563.4 KOO21563.1 - 8.4e-76 254.2 2.3 1.3e-75 253.7 1.6 1.3 1 0 0 1 1 1 1 Cadmium carbonic anhydrase repeat Acetyltransf_1 PF00583.19 KOO21563.1 - 0.0014 18.5 0.0 0.0039 17.1 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Nucleotid_trans PF03407.11 KOO21563.1 - 0.0018 18.0 0.0 0.0034 17.1 0.0 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Acetyltransf_3 PF13302.1 KOO21563.1 - 0.044 13.9 0.0 0.092 12.9 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Lant_dehyd_C PF04738.8 KOO21564.1 - 0.076 11.2 0.0 0.076 11.2 0.0 1.1 1 0 0 1 1 1 0 Lantibiotic dehydratase, C terminus PBP PF01161.15 KOO21565.1 - 7.8e-07 29.0 0.0 1.5e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein FA_desaturase PF00487.19 KOO21566.1 - 3.6e-19 69.2 15.9 7.6e-19 68.1 11.0 1.5 1 1 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.23 KOO21566.1 - 0.00013 21.7 0.0 0.00029 20.5 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain YccV-like PF08755.6 KOO21567.1 - 1.8e-11 43.8 0.0 3.7e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like PRKCSH PF07915.8 KOO21567.1 - 8.1e-08 32.9 10.0 4.2e-07 30.6 7.0 2.0 1 1 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.1 KOO21567.1 - 3.5e-06 26.5 1.2 5.4e-06 25.9 0.8 1.2 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein UBA PF00627.26 KOO21568.1 - 4.4e-07 29.5 0.2 1.2e-06 28.1 0.1 1.8 1 0 0 1 1 1 1 UBA/TS-N domain TPR_2 PF07719.12 KOO21568.1 - 0.044 13.7 3.8 3.3 7.8 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 KOO21568.1 - 0.057 13.0 4.5 0.58 9.8 0.7 3.0 3 0 0 3 3 3 0 TPR repeat TPR_19 PF14559.1 KOO21568.1 - 0.58 10.5 0.0 0.58 10.5 0.0 3.6 2 2 1 3 3 3 0 Tetratricopeptide repeat DUF952 PF06108.7 KOO21569.1 - 6.4e-05 22.7 0.0 9.3e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF952) Kinesin PF00225.18 KOO21570.1 - 1.5e-99 332.9 0.1 1.7e-99 332.6 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain AAA_22 PF13401.1 KOO21570.1 - 0.076 13.1 0.0 0.18 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain bZIP_1 PF00170.16 KOO21570.1 - 0.1 12.5 1.6 0.33 10.9 1.1 1.8 1 0 0 1 1 1 0 bZIP transcription factor Septin PF00735.13 KOO21571.1 - 2.8e-50 170.9 0.0 5.7e-50 169.9 0.0 1.4 1 1 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 KOO21571.1 - 8.1e-05 22.5 0.0 0.00012 21.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 KOO21571.1 - 0.0016 18.5 0.0 0.044 13.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KOO21571.1 - 0.005 16.8 0.1 0.026 14.5 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain Pox_A32 PF04665.7 KOO21571.1 - 0.015 14.5 0.0 0.025 13.8 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein PduV-EutP PF10662.4 KOO21571.1 - 0.044 13.2 0.0 0.11 11.9 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation MobB PF03205.9 KOO21571.1 - 0.059 13.0 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.22 KOO21571.1 - 0.073 13.3 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.1 KOO21571.1 - 0.083 12.7 0.1 0.29 11.0 0.0 1.9 1 1 0 1 1 1 0 AAA domain Miro PF08477.8 KOO21571.1 - 0.09 13.2 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein AAA_5 PF07728.9 KOO21571.1 - 0.093 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.1 KOO21571.1 - 0.12 11.9 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain UPF0079 PF02367.12 KOO21571.1 - 0.14 11.7 0.0 0.32 10.6 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 G-alpha PF00503.15 KOO21571.1 - 0.27 9.8 0.0 0.36 9.4 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit Form_Nir_trans PF01226.12 KOO21572.1 - 1.7e-69 233.5 21.8 1.9e-69 233.3 15.1 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter PHO4 PF01384.15 KOO21573.1 - 9.5e-81 270.9 13.4 1.2e-80 270.6 9.3 1.1 1 0 0 1 1 1 1 Phosphate transporter family Chloroa_b-bind PF00504.16 KOO21574.1 - 5.4e-26 91.7 0.0 7.3e-26 91.2 0.0 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Mito_carr PF00153.22 KOO21575.1 - 1.8e-40 136.5 9.7 3.5e-18 65.1 0.3 3.0 1 1 2 3 3 3 3 Mitochondrial carrier protein Filament PF00038.16 KOO21576.1 - 1.1e-05 25.0 13.9 2.4e-05 23.9 9.6 1.5 1 0 0 1 1 1 1 Intermediate filament protein BicD PF09730.4 KOO21576.1 - 0.0064 14.9 15.2 0.0097 14.3 10.5 1.2 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D CALCOCO1 PF07888.6 KOO21576.1 - 0.097 10.9 14.0 0.36 9.0 8.3 2.1 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Ycf1 PF05758.7 KOO21576.1 - 0.56 7.8 1.5 0.75 7.4 1.0 1.1 1 0 0 1 1 1 0 Ycf1 CENP-F_leu_zip PF10473.4 KOO21576.1 - 2.8 7.8 24.0 0.26 11.1 9.9 3.1 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IncA PF04156.9 KOO21576.1 - 3.3 7.2 16.9 0.034 13.7 1.2 2.7 1 1 1 2 2 2 0 IncA protein TMF_DNA_bd PF12329.3 KOO21576.1 - 3.8 7.3 10.3 0.21 11.4 1.2 2.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Fez1 PF06818.10 KOO21576.1 - 4.8 7.1 18.9 2.1 8.2 9.5 2.6 1 1 1 2 2 2 0 Fez1 EF-hand_7 PF13499.1 KOO21577.1 - 2.4e-17 62.8 3.8 9.9e-08 32.0 0.1 2.9 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.27 KOO21577.1 - 5.6e-15 53.4 1.6 0.00017 20.6 0.0 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 KOO21577.1 - 2.2e-14 51.9 2.7 0.00015 21.3 0.0 3.9 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.1 KOO21577.1 - 5.2e-09 35.5 3.9 0.00071 19.1 0.0 3.7 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.2 KOO21577.1 - 0.0005 19.7 4.0 0.058 13.1 0.1 3.2 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand Pox_D5 PF03288.11 KOO21577.1 - 0.0064 16.7 0.5 0.61 10.3 0.0 2.9 3 0 0 3 3 3 1 Poxvirus D5 protein-like EF-hand_5 PF13202.1 KOO21577.1 - 0.087 12.2 3.4 8.9 5.8 0.0 3.6 4 0 0 4 4 4 0 EF hand PP2C_2 PF13672.1 KOO21579.1 - 0.66 9.3 5.6 1.2 8.5 3.9 1.3 1 0 0 1 1 1 0 Protein phosphatase 2C Thioredoxin PF00085.15 KOO21580.1 - 9.8e-20 70.1 0.0 5.9e-19 67.6 0.0 2.2 3 0 0 3 3 3 1 Thioredoxin Glyoxalase_2 PF12681.2 KOO21580.1 - 1.3e-10 41.8 0.1 1.7e-06 28.5 0.0 2.9 3 0 0 3 3 3 2 Glyoxalase-like domain Thioredoxin_8 PF13905.1 KOO21580.1 - 1.2e-05 25.3 0.0 0.0018 18.3 0.0 2.3 1 1 1 2 2 2 2 Thioredoxin-like Glyoxalase PF00903.20 KOO21580.1 - 2.1e-05 24.5 0.0 0.22 11.5 0.0 3.5 3 1 0 3 3 3 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Thioredoxin_9 PF14595.1 KOO21580.1 - 5.7e-05 22.6 0.0 9.3e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_3 PF13192.1 KOO21580.1 - 0.00034 20.3 0.0 0.00074 19.2 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin domain TrbC_Ftype PF09673.5 KOO21580.1 - 0.02 14.4 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein Thioredoxin_7 PF13899.1 KOO21580.1 - 0.041 13.8 0.0 0.079 12.9 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin_2 PF13098.1 KOO21580.1 - 0.067 13.3 0.1 0.36 11.0 0.0 2.0 1 1 0 1 1 1 0 Thioredoxin-like domain DIM1 PF02966.11 KOO21580.1 - 0.14 11.6 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 Mitosis protein DIM1 GNT-I PF03071.10 KOO21581.1 - 2.3e-60 204.3 0.0 3.3e-60 203.8 0.0 1.1 1 0 0 1 1 1 1 GNT-I family Glyco_transf_18 PF15024.1 KOO21581.1 - 0.00015 20.2 1.9 0.00021 19.7 1.3 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 18 MORN PF02493.15 KOO21582.1 - 3.1e-24 83.1 29.9 1.3e-05 24.6 1.5 5.2 5 0 0 5 5 5 5 MORN repeat EF-hand_1 PF00036.27 KOO21583.1 - 3.1e-14 51.1 2.0 0.00094 18.3 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 KOO21583.1 - 4.1e-14 51.1 3.4 2.5e-05 23.7 0.1 3.8 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.1 KOO21583.1 - 2.5e-11 43.5 0.1 7.1e-06 26.0 0.0 2.9 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO21583.1 - 6.3e-10 38.5 3.1 0.022 14.3 0.2 3.5 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO21583.1 - 5.7e-08 31.7 3.9 0.13 11.6 0.2 3.5 3 0 0 3 3 3 3 EF hand zf-HC2 PF13490.1 KOO21583.1 - 1.2 9.0 4.9 11 6.0 0.0 2.8 3 0 0 3 3 3 0 Putative zinc-finger KLRAQ PF10205.4 KOO21584.1 - 0.0099 15.8 0.5 0.015 15.3 0.3 1.3 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein Homoserine_dh PF00742.14 KOO21584.1 - 0.051 13.2 2.1 0.059 13.0 1.4 1.2 1 0 0 1 1 1 0 Homoserine dehydrogenase Striatin PF08232.7 KOO21584.1 - 0.058 13.6 2.1 0.075 13.3 1.5 1.2 1 0 0 1 1 1 0 Striatin family HMG14_17 PF01101.13 KOO21584.1 - 0.083 13.5 2.7 0.12 13.0 1.9 1.2 1 0 0 1 1 1 0 HMG14 and HMG17 DASH_Dad2 PF08654.5 KOO21584.1 - 0.088 12.8 0.9 0.16 12.0 0.6 1.5 1 1 0 1 1 1 0 DASH complex subunit Dad2 Fez1 PF06818.10 KOO21584.1 - 0.17 11.8 4.6 0.21 11.5 3.2 1.1 1 0 0 1 1 1 0 Fez1 VSG_B PF13206.1 KOO21584.1 - 0.35 9.9 6.6 0.41 9.7 4.5 1.1 1 0 0 1 1 1 0 Trypanosomal VSG domain ATG16 PF08614.6 KOO21584.1 - 0.65 9.7 7.8 0.59 9.9 2.3 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF3645 PF12359.3 KOO21586.1 - 1.6e-16 59.1 0.3 1.5e-15 56.0 0.1 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3645) Thioredoxin_8 PF13905.1 KOO21586.1 - 1.3e-09 38.0 0.0 2.9e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like C1_3 PF07649.7 KOO21586.1 - 3.7 7.6 18.3 0.045 13.7 7.4 1.9 2 0 0 2 2 2 0 C1-like domain Pkinase PF00069.20 KOO21587.1 - 2.3e-41 141.6 0.0 3.4e-41 141.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21587.1 - 4.8e-29 101.2 0.0 6.6e-29 100.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO21587.1 - 0.021 14.5 0.1 0.048 13.3 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.17 KOO21587.1 - 0.032 13.5 0.3 0.21 10.8 0.0 2.0 1 1 1 2 2 2 0 RIO1 family PIP49_C PF12260.3 KOO21587.1 - 0.14 11.5 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 V-SNARE_C PF12352.3 KOO21588.1 - 0.00017 21.6 1.9 0.00027 20.9 0.5 1.9 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus C2 PF00168.25 KOO21588.1 - 0.00022 20.9 0.0 0.015 15.1 0.0 2.6 1 1 0 1 1 1 1 C2 domain Fn_bind PF02986.9 KOO21588.1 - 0.04 13.4 0.0 0.095 12.2 0.0 1.7 1 0 0 1 1 1 0 Fibronectin binding repeat DnaJ PF00226.26 KOO21590.1 - 9e-20 70.1 0.4 9e-20 70.1 0.3 1.6 2 0 0 2 2 2 1 DnaJ domain MORN PF02493.15 KOO21590.1 - 1.6e-08 33.8 1.4 0.0079 15.8 0.0 3.6 3 0 0 3 3 3 2 MORN repeat Fer2 PF00111.22 KOO21590.1 - 0.071 12.8 0.4 0.14 11.8 0.3 1.6 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain MIB_HERC2 PF06701.8 KOO21591.1 - 5.4e-06 26.2 5.6 1.8e-05 24.6 3.9 1.9 1 0 0 1 1 1 1 Mib_herc2 EF-hand_5 PF13202.1 KOO21591.1 - 0.00012 21.2 0.4 0.00041 19.5 0.1 2.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO21591.1 - 0.0006 19.4 0.2 0.0026 17.4 0.1 2.2 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.27 KOO21591.1 - 0.0023 17.0 0.3 0.014 14.6 0.1 2.3 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO21591.1 - 0.094 12.8 0.0 0.35 11.0 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_8 PF13833.1 KOO21591.1 - 0.13 11.9 0.1 0.33 10.5 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain pair Bestrophin PF01062.16 KOO21592.1 - 3.6e-24 85.2 0.2 1.5e-23 83.1 0.1 1.8 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel DUF608 PF04685.8 KOO21593.1 - 0.11 11.2 0.0 0.2 10.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF608 IncA PF04156.9 KOO21594.1 - 1.7 8.1 31.2 2.3 7.7 5.0 3.0 2 1 1 3 3 3 0 IncA protein DivIC PF04977.10 KOO21594.1 - 5.7 6.5 15.2 1 8.8 0.7 3.4 3 0 0 3 3 3 0 Septum formation initiator TMF_DNA_bd PF12329.3 KOO21594.1 - 6.2 6.7 16.7 3.9 7.3 1.8 3.9 4 0 0 4 4 4 0 TATA element modulatory factor 1 DNA binding ATG16 PF08614.6 KOO21594.1 - 6.6 6.4 32.4 0.19 11.5 7.7 3.6 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) Pkinase PF00069.20 KOO21595.1 - 1.6e-21 76.6 0.0 2.3e-21 76.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21595.1 - 3.7e-16 58.9 0.0 4.5e-16 58.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO21595.1 - 0.0012 18.6 1.3 0.034 13.8 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family ABC_tran PF00005.22 KOO21596.1 - 3.1e-47 160.3 0.0 2.5e-27 95.8 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC_membrane PF00664.18 KOO21596.1 - 2.2e-32 112.5 20.0 1.5e-16 60.6 11.5 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.14 KOO21596.1 - 4.1e-08 32.7 1.4 0.18 11.0 0.0 4.2 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 KOO21596.1 - 5.1e-06 26.5 1.2 0.069 13.1 0.0 3.0 3 0 0 3 3 3 2 AAA ATPase domain DUF258 PF03193.11 KOO21596.1 - 2.1e-05 23.7 0.8 0.001 18.3 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 KOO21596.1 - 2.1e-05 24.4 0.5 0.083 12.8 0.1 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.1 KOO21596.1 - 4.2e-05 22.9 1.0 0.23 10.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.13 KOO21596.1 - 0.00017 21.1 0.1 0.054 12.9 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_22 PF13401.1 KOO21596.1 - 0.00021 21.4 0.2 0.8 9.8 0.0 3.2 2 1 0 2 2 2 1 AAA domain T2SE PF00437.15 KOO21596.1 - 0.0003 19.7 0.3 0.016 14.1 0.0 2.6 2 1 0 2 2 2 1 Type II/IV secretion system protein Miro PF08477.8 KOO21596.1 - 0.00033 21.1 1.7 0.57 10.6 0.1 2.8 2 0 0 2 2 2 2 Miro-like protein AAA_17 PF13207.1 KOO21596.1 - 0.00081 20.2 0.1 1.5 9.6 0.0 2.9 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.18 KOO21596.1 - 0.00087 19.1 0.4 0.13 12.0 0.0 2.6 2 0 0 2 2 2 1 Dynamin family AAA_21 PF13304.1 KOO21596.1 - 0.0011 18.9 0.0 1 9.2 0.0 3.8 4 0 0 4 4 4 1 AAA domain MobB PF03205.9 KOO21596.1 - 0.0015 18.2 3.1 0.48 10.1 0.1 2.8 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B NB-ARC PF00931.17 KOO21596.1 - 0.0017 17.2 1.8 0.74 8.6 0.1 2.3 2 0 0 2 2 2 2 NB-ARC domain AAA_18 PF13238.1 KOO21596.1 - 0.0083 16.4 0.1 1.2 9.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.1 KOO21596.1 - 0.011 16.0 0.0 0.97 9.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 KOO21596.1 - 0.015 14.9 1.3 2.9 7.5 0.1 2.6 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.1 KOO21596.1 - 0.018 14.6 8.3 0.75 9.3 0.0 3.5 4 0 0 4 4 3 0 AAA domain KAP_NTPase PF07693.9 KOO21596.1 - 0.03 13.3 0.0 0.44 9.4 0.0 2.3 2 0 0 2 2 2 0 KAP family P-loop domain DEAD PF00270.24 KOO21596.1 - 0.033 13.6 0.1 6.7 6.1 0.0 2.8 3 0 0 3 3 3 0 DEAD/DEAH box helicase AAA_25 PF13481.1 KOO21596.1 - 0.039 13.3 0.2 8.9 5.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 KOO21596.1 - 0.044 12.8 0.5 2.9 6.9 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin TrwB_AAD_bind PF10412.4 KOO21596.1 - 0.044 12.4 1.1 1.9 7.0 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain DUF87 PF01935.12 KOO21596.1 - 0.045 13.5 4.6 0.25 11.1 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF87 SbcCD_C PF13558.1 KOO21596.1 - 0.064 13.1 0.0 18 5.2 0.0 3.0 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit ATP_bind_1 PF03029.12 KOO21596.1 - 0.066 12.7 1.7 1.2 8.5 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein cobW PF02492.14 KOO21596.1 - 0.086 12.2 2.4 2 7.8 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Pox_A32 PF04665.7 KOO21596.1 - 0.1 11.8 1.2 0.42 9.8 0.1 2.1 2 0 0 2 2 2 0 Poxvirus A32 protein ATP-synt_ab PF00006.20 KOO21596.1 - 0.1 12.0 0.0 17 4.8 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain ResIII PF04851.10 KOO21596.1 - 0.12 12.1 0.2 0.49 10.2 0.0 2.0 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit ArgK PF03308.11 KOO21596.1 - 0.14 10.9 1.8 2.3 6.9 0.1 2.3 2 0 0 2 2 2 0 ArgK protein Arch_ATPase PF01637.13 KOO21596.1 - 0.17 11.5 1.9 2.8 7.5 0.0 2.9 3 0 0 3 3 2 0 Archaeal ATPase AAA_10 PF12846.2 KOO21596.1 - 0.66 9.3 6.2 2 7.7 0.3 2.7 2 1 0 3 3 3 0 AAA-like domain NTPase_1 PF03266.10 KOO21596.1 - 1 9.0 5.4 12 5.6 0.2 3.1 3 0 0 3 3 3 0 NTPase DnaI_N PF07319.6 KOO21597.1 - 0.13 12.5 0.4 0.45 10.8 0.1 2.0 2 0 0 2 2 2 0 Primosomal protein DnaI N-terminus XPG_I_2 PF12813.2 KOO21597.1 - 5.1 6.5 8.1 1.5 8.2 2.7 2.1 2 1 0 2 2 2 0 XPG domain containing IQ PF00612.22 KOO21597.1 - 6.9 6.6 16.1 5 7.0 0.6 3.4 3 0 0 3 3 3 0 IQ calmodulin-binding motif PUF PF00806.14 KOO21598.1 - 3.4e-47 155.3 0.1 1.1e-05 24.6 0.0 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CDK2AP PF09806.4 KOO21598.1 - 0.13 12.5 1.8 0.18 11.9 0.6 1.8 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein ubiquitin PF00240.18 KOO21599.1 - 6.2e-09 35.1 0.0 0.02 14.2 0.0 3.6 4 0 0 4 4 4 3 Ubiquitin family RCC1 PF00415.13 KOO21600.1 - 6.6e-36 122.2 3.2 6.2e-09 35.9 0.2 4.3 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO21600.1 - 1.2e-13 50.2 21.8 1.6e-07 30.7 1.5 5.0 4 1 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat DUF2476 PF10630.4 KOO21600.1 - 0.054 13.3 0.0 0.079 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2476) ETF_QO PF05187.8 KOO21601.1 - 1.6e-40 137.5 0.0 2.7e-40 136.7 0.0 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase DAO PF01266.19 KOO21601.1 - 6.9e-09 35.0 0.4 9.7e-05 21.4 0.2 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 KOO21601.1 - 4.1e-08 33.1 0.0 1.9e-07 31.0 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 KOO21601.1 - 2.4e-05 23.5 0.0 0.0011 18.1 0.0 2.1 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.19 KOO21601.1 - 4.8e-05 22.3 0.7 0.0022 16.8 0.3 2.1 1 1 1 2 2 2 1 FAD binding domain FAD_binding_3 PF01494.14 KOO21601.1 - 5.2e-05 22.4 0.2 0.00011 21.4 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.1 KOO21601.1 - 0.00033 20.4 0.1 0.0007 19.3 0.1 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Fer4_7 PF12838.2 KOO21601.1 - 0.00033 20.9 3.7 0.00074 19.8 2.5 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Pyr_redox PF00070.22 KOO21601.1 - 0.00069 19.9 0.2 0.15 12.5 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 KOO21601.1 - 0.001 17.6 0.2 0.0017 16.9 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein Fer4_9 PF13187.1 KOO21601.1 - 0.0011 19.1 4.1 0.0022 18.2 2.8 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain FAD_oxidored PF12831.2 KOO21601.1 - 0.0023 17.0 0.7 0.0035 16.4 0.5 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.9 KOO21601.1 - 0.0025 16.5 0.9 0.0052 15.4 0.1 1.8 2 0 0 2 2 2 1 Tryptophan halogenase Fer4_10 PF13237.1 KOO21601.1 - 0.0036 17.0 2.4 0.0077 16.0 1.7 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_17 PF13534.1 KOO21601.1 - 0.004 17.4 1.9 0.0079 16.5 1.3 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.1 KOO21601.1 - 0.0061 16.4 1.6 0.013 15.3 1.1 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Pyr_redox_2 PF07992.9 KOO21601.1 - 0.01 15.7 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Fer4_8 PF13183.1 KOO21601.1 - 0.01 15.8 0.7 0.021 14.8 0.5 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Pyr_redox_3 PF13738.1 KOO21601.1 - 0.016 15.2 0.0 0.025 14.6 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Fer4_2 PF12797.2 KOO21601.1 - 0.056 13.3 2.3 0.14 12.1 1.6 1.7 1 0 0 1 1 1 0 4Fe-4S binding domain Lycopene_cycl PF05834.7 KOO21601.1 - 0.073 11.9 0.2 0.11 11.4 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Fer4 PF00037.22 KOO21601.1 - 0.081 12.5 3.7 0.049 13.2 1.1 1.8 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_6 PF12837.2 KOO21601.1 - 2.8 7.9 6.9 0.37 10.7 1.9 1.8 2 0 0 2 2 1 0 4Fe-4S binding domain DUF2040 PF09745.4 KOO21602.1 - 2.3e-26 92.0 21.2 2.3e-26 92.0 14.7 1.9 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 55 (DUF2040) ATP_bind_1 PF03029.12 KOO21603.1 - 8.2e-42 143.3 0.0 1.1e-41 142.8 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein SSF PF00474.12 KOO21603.1 - 6.5e-16 57.9 30.6 3.5e-15 55.5 21.2 1.9 1 1 0 1 1 1 1 Sodium:solute symporter family DUF3529 PF12046.3 KOO21603.1 - 0.37 9.7 0.0 0.37 9.7 0.0 2.8 4 0 0 4 4 4 0 Protein of unknown function (DUF3529) EF-hand_1 PF00036.27 KOO21604.1 - 5.6e-20 69.0 7.4 0.00045 19.3 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO21604.1 - 6e-20 69.2 6.1 9.9e-05 21.9 0.1 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO21604.1 - 1.7e-16 60.0 2.9 3.1e-06 27.2 0.2 3.9 1 1 2 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.1 KOO21604.1 - 1.7e-14 53.1 4.1 9.6e-07 28.3 0.1 3.6 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO21604.1 - 1.9e-13 49.0 10.5 0.0019 17.4 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_4 PF12763.2 KOO21604.1 - 0.027 14.1 1.4 3.7 7.3 0.0 3.2 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO21604.1 - 0.15 11.7 0.8 4.2 7.0 0.1 2.8 3 1 0 3 3 3 0 EF hand GTP_EFTU PF00009.22 KOO21605.1 - 4.5e-46 156.6 0.0 6.2e-46 156.2 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 KOO21605.1 - 3.1e-24 84.8 0.0 5.7e-24 83.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.19 KOO21605.1 - 1.5e-22 79.2 0.0 6.4e-22 77.2 0.0 2.1 3 0 0 3 3 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 KOO21605.1 - 1.9e-10 40.6 0.0 4.5e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 KOO21605.1 - 4.5e-08 33.0 0.0 8.2e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 KOO21605.1 - 1.7e-07 31.7 0.0 3.4e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein EFG_II PF14492.1 KOO21605.1 - 1.5e-05 24.7 0.1 3.8e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II Dynamin_N PF00350.18 KOO21605.1 - 8.9e-05 22.3 0.0 0.099 12.4 0.0 2.3 1 1 1 2 2 2 2 Dynamin family SRPRB PF09439.5 KOO21605.1 - 0.0034 16.6 0.0 1 8.5 0.0 2.4 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit Ras PF00071.17 KOO21605.1 - 0.0077 15.6 0.0 0.077 12.3 0.0 2.1 2 0 0 2 2 2 1 Ras family Septin PF00735.13 KOO21605.1 - 0.079 11.9 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Septin AceK PF06315.6 KOO21605.1 - 0.33 9.1 0.0 0.49 8.6 0.0 1.1 1 0 0 1 1 1 0 Isocitrate dehydrogenase kinase/phosphatase (AceK) TIG PF01833.19 KOO21607.1 - 1.1e-25 89.4 7.9 3.4e-10 39.7 0.8 4.1 4 1 0 4 4 4 3 IPT/TIG domain DENN PF02141.16 KOO21608.1 - 5.1e-37 127.3 1.7 9.5e-37 126.5 1.2 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.14 KOO21608.1 - 5.7e-07 29.5 0.0 1.3e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 dDENN domain Lipase_3 PF01764.20 KOO21608.1 - 0.0013 18.3 0.0 0.0061 16.1 0.0 2.0 2 0 0 2 2 2 1 Lipase (class 3) DUF3530 PF12048.3 KOO21608.1 - 0.055 12.4 0.0 0.088 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) SPA PF08616.5 KOO21608.1 - 0.061 13.0 0.2 0.11 12.1 0.1 1.4 1 0 0 1 1 1 0 Stabilization of polarity axis V-ATPase_H_N PF03224.9 KOO21609.1 - 8.1e-58 195.9 0.0 2.5e-56 191.0 0.0 2.0 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.3 KOO21609.1 - 2.5e-42 143.5 0.0 1.3e-39 134.7 0.0 2.4 2 0 0 2 2 2 2 V-ATPase subunit H Arm PF00514.18 KOO21609.1 - 7.9e-12 44.5 7.4 0.016 15.0 0.0 5.7 6 0 0 6 6 6 4 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO21609.1 - 1e-06 28.9 2.4 0.029 14.6 0.0 3.6 2 1 2 4 4 4 3 HEAT repeats HEAT PF02985.17 KOO21609.1 - 0.015 15.3 0.1 9.6 6.5 0.0 3.8 4 0 0 4 4 4 0 HEAT repeat Aconitase_B_N PF11791.3 KOO21609.1 - 0.02 14.7 0.0 0.37 10.5 0.0 2.8 3 0 0 3 3 3 0 Aconitate B N-terminal domain HEAT_EZ PF13513.1 KOO21609.1 - 0.21 12.1 2.3 14 6.3 0.0 4.1 5 0 0 5 5 5 0 HEAT-like repeat zf-DNL PF05180.7 KOO21610.1 - 8.9e-27 92.6 0.2 1.2e-26 92.1 0.1 1.2 1 0 0 1 1 1 1 DNL zinc finger RuvA_C PF07499.8 KOO21610.1 - 0.02 15.0 0.2 1.5 9.0 0.0 2.4 2 0 0 2 2 2 0 RuvA, C-terminal domain Elf1 PF05129.8 KOO21610.1 - 0.023 14.3 0.5 0.04 13.6 0.4 1.3 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like ALF PF03752.8 KOO21610.1 - 0.039 13.8 0.5 0.11 12.4 0.3 1.7 1 0 0 1 1 1 0 Short repeats of unknown function Lar_restr_allev PF14354.1 KOO21610.1 - 0.062 13.6 0.1 0.12 12.7 0.1 1.5 1 0 0 1 1 1 0 Restriction alleviation protein Lar Zn_Tnp_IS1 PF03811.8 KOO21610.1 - 0.21 11.1 2.5 0.42 10.1 0.1 2.3 2 0 0 2 2 2 0 InsA N-terminal domain Calpain_III PF01067.17 KOO21611.1 - 6.2e-28 97.2 0.0 4.9e-09 35.9 0.0 4.2 4 0 0 4 4 4 4 Calpain large subunit, domain III Peptidase_C2 PF00648.16 KOO21611.1 - 2.2e-11 43.3 0.0 4.9e-11 42.1 0.0 1.5 2 0 0 2 2 2 1 Calpain family cysteine protease NAD_binding_5 PF07994.7 KOO21612.1 - 1.2e-35 123.4 0.0 2.1e-35 122.6 0.0 1.3 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.12 KOO21612.1 - 6.4e-21 74.2 0.0 9.7e-21 73.7 0.0 1.3 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase PfkB PF00294.19 KOO21612.1 - 1.3e-18 67.1 0.0 3e-18 65.9 0.0 1.6 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Med4 PF10018.4 KOO21612.1 - 7.2e-05 22.2 2.9 0.00092 18.6 2.0 2.1 1 1 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 DNA_methylase PF00145.12 KOO21614.1 - 1.4e-12 47.4 0.0 4.7e-09 35.8 0.0 2.0 1 1 1 2 2 2 2 C-5 cytosine-specific DNA methylase Ank_2 PF12796.2 KOO21615.1 - 3.4e-13 49.7 4.7 5.3e-07 29.8 0.7 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO21615.1 - 1.5e-12 46.6 8.8 5e-05 22.8 0.0 4.5 4 1 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 KOO21615.1 - 4e-09 36.7 0.3 0.0046 17.4 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO21615.1 - 4.2e-08 33.1 0.2 0.0026 17.9 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO21615.1 - 0.00016 21.6 1.3 2.6 8.5 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat AA_kinase PF00696.23 KOO21617.1 - 8.3e-37 127.0 2.5 9.2e-37 126.8 1.7 1.0 1 0 0 1 1 1 1 Amino acid kinase family BNR PF02012.15 KOO21618.1 - 2.7e-05 23.3 13.0 2.2 8.4 0.1 5.7 5 0 0 5 5 5 3 BNR/Asp-box repeat PSII_BNR PF14870.1 KOO21618.1 - 0.00063 18.8 4.5 0.038 12.9 0.1 3.4 3 1 1 4 4 4 2 Photosynthesis system II assembly factor YCF48 OprB PF04966.7 KOO21618.1 - 0.0023 17.1 0.1 0.0042 16.2 0.1 1.4 1 0 0 1 1 1 1 Carbohydrate-selective porin, OprB family DUF4185 PF13810.1 KOO21618.1 - 0.016 14.1 0.4 2.4 6.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4185) Neur_chan_memb PF02932.11 KOO21619.1 - 7.9e-06 25.9 0.9 1.2e-05 25.3 0.6 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Annexin PF00191.15 KOO21620.1 - 5.6e-74 243.9 9.7 1.7e-15 56.6 0.1 8.5 8 0 0 8 8 8 8 Annexin Mito_fiss_reg PF05308.6 KOO21620.1 - 2.1 7.6 6.4 4.2 6.6 4.4 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator EF-hand_7 PF13499.1 KOO21621.1 - 8.3e-10 38.6 2.7 2.6e-07 30.6 0.3 1.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO21621.1 - 1.4e-09 36.5 0.3 0.0019 17.4 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO21621.1 - 3.2e-09 35.8 0.5 0.0028 17.4 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO21621.1 - 2e-07 30.0 2.6 0.011 15.0 0.3 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO21621.1 - 5.3e-05 22.7 0.2 0.00077 19.0 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair RII_binding_1 PF10522.4 KOO21621.1 - 0.019 15.0 0.7 6.8 7.2 0.0 3.6 3 0 0 3 3 3 0 RII binding domain C2 PF00168.25 KOO21622.1 - 2.6e-37 126.5 0.0 3.4e-19 68.4 0.0 2.4 2 0 0 2 2 2 2 C2 domain EF-hand_1 PF00036.27 KOO21622.1 - 5.2e-19 66.0 10.2 3.2e-06 26.0 0.2 4.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 KOO21622.1 - 3e-17 60.8 4.2 2.2e-05 23.9 0.1 3.8 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.1 KOO21622.1 - 2e-15 55.2 9.0 0.00011 21.3 0.0 4.0 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.1 KOO21622.1 - 5.4e-13 48.8 5.3 2.4e-10 40.4 0.8 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO21622.1 - 6.7e-13 48.0 7.6 6.2e-10 38.5 0.4 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.2 KOO21622.1 - 0.028 14.1 5.1 1 9.1 0.3 3.0 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand Ank_2 PF12796.2 KOO21623.1 - 5e-33 113.2 0.4 2.6e-17 62.9 0.1 3.0 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO21623.1 - 1.7e-26 90.6 4.6 3.4e-05 23.4 0.2 5.6 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.1 KOO21623.1 - 7.9e-25 86.7 0.6 2.7e-09 37.2 0.0 3.6 1 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO21623.1 - 1e-18 66.8 3.6 1.2e-08 34.9 0.1 4.6 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO21623.1 - 1.2e-15 55.9 1.2 0.089 13.0 0.1 5.8 5 0 0 5 5 5 5 Ankyrin repeat DUF4551 PF15087.1 KOO21623.1 - 1.2 7.3 4.4 1.7 6.9 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) PT PF04886.7 KOO21624.1 - 0.039 13.2 8.3 0.095 12.0 5.8 1.6 1 0 0 1 1 1 0 PT repeat EF-hand_8 PF13833.1 KOO21625.1 - 0.0037 16.8 0.2 0.011 15.3 0.1 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.1 KOO21625.1 - 0.08 13.0 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.1 KOO21625.1 - 0.091 12.6 0.7 6.8 6.8 0.0 3.3 3 0 0 3 3 3 0 EF-hand domain EF-hand_7 PF13499.1 KOO21626.1 - 4e-09 36.4 0.0 0.0015 18.6 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO21626.1 - 2.8e-05 23.6 0.0 0.013 15.1 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO21626.1 - 0.0009 18.3 0.4 3 7.3 0.0 3.8 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.1 KOO21626.1 - 0.013 15.3 0.3 1.6 8.7 0.0 3.5 4 0 0 4 4 4 0 EF-hand domain Aa_trans PF01490.13 KOO21627.1 - 1.2e-11 43.7 8.5 1.4e-11 43.5 5.9 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Ilm1 PF10311.4 KOO21627.1 - 0.0037 16.7 0.5 0.0057 16.1 0.3 1.3 1 1 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 Peptidase_S8 PF00082.17 KOO21628.1 - 8e-27 94.1 13.4 5.2e-26 91.4 5.6 2.7 2 1 0 2 2 2 1 Subtilase family Reprolysin_2 PF13574.1 KOO21628.1 - 0.0008 19.5 0.0 0.0035 17.4 0.0 2.0 1 1 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.1 KOO21628.1 - 0.01 16.3 0.0 0.072 13.6 0.0 2.6 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like stn_TNFRSF12A PF12191.3 KOO21628.1 - 0.57 10.2 6.6 1.7 8.7 0.0 2.7 2 0 0 2 2 2 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain Amino_oxidase PF01593.19 KOO21629.1 - 2.7e-62 211.3 9.7 3.8e-54 184.4 1.4 3.2 2 1 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 KOO21629.1 - 9.5e-08 31.9 1.8 2.8e-07 30.4 0.4 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 KOO21629.1 - 4.7e-07 30.0 4.1 0.0045 17.0 0.1 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 KOO21629.1 - 2.2e-06 27.5 1.1 0.011 15.5 0.1 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding Thi4 PF01946.12 KOO21629.1 - 0.0055 15.8 0.5 0.012 14.7 0.4 1.5 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.9 KOO21629.1 - 0.015 13.8 0.7 3.4 6.0 0.0 2.2 2 0 0 2 2 2 0 HI0933-like protein DAO PF01266.19 KOO21629.1 - 0.02 13.7 4.0 0.051 12.4 1.2 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox PF00070.22 KOO21629.1 - 0.069 13.5 1.0 2.3 8.6 0.2 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Ribosomal_60s PF00428.14 KOO21630.1 - 2.4 8.6 6.9 0.4 11.0 1.2 2.3 1 1 1 2 2 2 0 60s Acidic ribosomal protein Exostosin PF03016.10 KOO21631.1 - 1.2e-14 54.0 0.0 1.4e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 Exostosin family DUF4544 PF15077.1 KOO21632.1 - 1.1 8.7 4.6 0.23 10.9 0.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4544) EF-hand_7 PF13499.1 KOO21633.1 - 1.6e-06 28.1 0.4 3e-06 27.2 0.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO21633.1 - 3.4e-05 23.3 0.1 0.0092 15.7 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO21633.1 - 0.00024 20.1 3.4 0.016 14.5 0.0 2.7 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO21633.1 - 0.006 16.1 0.3 0.018 14.6 0.1 1.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO21633.1 - 0.13 11.6 0.1 0.13 11.6 0.1 2.0 2 0 0 2 2 2 0 EF hand Ank_2 PF12796.2 KOO21636.1 - 1.1e-16 60.9 0.4 5.1e-15 55.5 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO21636.1 - 3.6e-15 54.9 4.4 4.3e-08 32.5 0.2 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 KOO21636.1 - 2.5e-11 43.7 0.1 6.7e-07 29.6 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO21636.1 - 4.4e-11 42.6 2.5 1.4e-07 31.4 0.2 3.9 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO21636.1 - 1e-09 37.6 0.5 0.0018 18.3 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Band_7 PF01145.20 KOO21638.1 - 4.1e-19 69.1 1.7 5.6e-19 68.7 1.2 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family DHHA2 PF02833.9 KOO21638.1 - 0.044 13.9 0.1 0.13 12.4 0.0 1.7 1 1 1 2 2 2 0 DHHA2 domain Band_7_1 PF13421.1 KOO21638.1 - 0.068 12.6 0.1 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family zf-TAZ PF02135.11 KOO21640.1 - 0.00091 19.1 1.7 0.0017 18.2 1.2 1.4 1 0 0 1 1 1 1 TAZ zinc finger Pilus_CpaD PF09476.5 KOO21640.1 - 0.11 12.0 0.2 0.51 9.7 0.1 2.0 2 0 0 2 2 2 0 Pilus biogenesis CpaD protein (pilus_cpaD) Toxin_7 PF05980.7 KOO21641.1 - 0.12 12.3 0.5 0.22 11.5 0.3 1.3 1 0 0 1 1 1 0 Toxin 7 Band_7 PF01145.20 KOO21642.1 - 1.3e-25 90.3 0.7 1.9e-25 89.7 0.4 1.3 1 1 0 1 1 1 1 SPFH domain / Band 7 family DUF3766 PF12611.3 KOO21642.1 - 0.024 14.1 0.8 0.096 12.2 0.6 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3766) DUF1295 PF06966.7 KOO21643.1 - 3.8e-45 154.0 3.6 4.4e-45 153.8 2.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.9 KOO21643.1 - 0.0015 18.6 0.1 0.0072 16.5 0.0 2.0 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 KOO21643.1 - 0.019 15.0 0.0 0.052 13.6 0.0 1.9 1 0 0 1 1 1 0 Phospholipid methyltransferase OmpH PF03938.9 KOO21645.1 - 0.039 13.8 8.4 0.043 13.7 5.8 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Enhancin PF03272.8 KOO21645.1 - 0.048 11.5 0.2 0.055 11.3 0.2 1.1 1 0 0 1 1 1 0 Viral enhancin protein DUF2203 PF09969.4 KOO21645.1 - 0.17 12.0 2.4 0.35 11.1 1.7 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) V_ATPase_I PF01496.14 KOO21645.1 - 0.18 9.6 1.3 0.2 9.5 0.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family KfrA_N PF11740.3 KOO21645.1 - 0.93 9.9 13.3 1.9 8.9 9.2 1.5 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term NDUFB10 PF10249.4 KOO21646.1 - 9.8e-05 22.5 0.0 0.00013 22.0 0.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 DAGAT PF03982.8 KOO21647.1 - 3.9e-30 104.5 0.0 5.3e-30 104.1 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Acyltransferase PF01553.16 KOO21647.1 - 0.021 14.2 0.0 0.034 13.5 0.0 1.4 1 0 0 1 1 1 0 Acyltransferase HATPase_c PF02518.21 KOO21648.1 - 9.2e-07 28.5 0.0 1.7e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_mis_repair PF01119.14 KOO21648.1 - 1.1e-06 28.1 0.0 1.3e-05 24.6 0.0 2.1 1 1 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 KOO21648.1 - 1.6e-05 24.5 0.1 3.3e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase EF-hand_1 PF00036.27 KOO21649.1 - 2.4e-07 29.5 0.1 1.6e-05 23.8 0.0 2.6 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO21649.1 - 1.4e-06 27.7 0.1 0.00023 20.8 0.0 2.9 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.1 KOO21649.1 - 1.5e-06 28.2 0.3 3.2e-05 23.9 0.2 2.4 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_10 PF14788.1 KOO21649.1 - 1.9e-06 27.3 0.6 0.047 13.3 0.0 2.7 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.1 KOO21649.1 - 6.1e-06 25.3 0.3 0.0037 16.5 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO21649.1 - 0.0023 17.5 0.1 0.86 9.2 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair 2OG-FeII_Oxy PF03171.15 KOO21650.1 - 0.024 14.8 0.1 0.04 14.1 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.1 KOO21650.1 - 0.1 12.9 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase zf-DHHC PF01529.15 KOO21652.1 - 6.4e-14 51.7 0.3 5.8e-13 48.5 0.1 2.2 1 1 0 1 1 1 1 DHHC palmitoyltransferase RDD PF06271.7 KOO21652.1 - 2.2 8.1 9.3 8.9 6.2 2.9 3.1 2 1 0 2 2 2 0 RDD family Nucleoplasmin PF03066.10 KOO21653.1 - 0.68 9.4 6.4 1.1 8.7 4.4 1.3 1 0 0 1 1 1 0 Nucleoplasmin CENP-B_dimeris PF09026.5 KOO21653.1 - 1.2 9.4 9.8 2.5 8.3 6.8 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Dicty_REP PF05086.7 KOO21653.1 - 5.7 4.5 6.8 7.5 4.1 4.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Acetyltransf_3 PF13302.1 KOO21654.1 - 5.2e-10 39.6 0.0 1.5e-07 31.6 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Abhydrolase_5 PF12695.2 KOO21654.1 - 1e-08 35.0 0.7 2.2e-08 33.9 0.5 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO21654.1 - 1.1e-08 35.1 4.1 1.1e-07 32.0 0.3 3.5 2 2 2 4 4 4 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO21654.1 - 1.4e-05 24.7 0.1 2.4e-05 24.0 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Acetyltransf_8 PF13523.1 KOO21654.1 - 0.023 14.6 0.0 0.056 13.3 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 KOO21654.1 - 0.075 13.0 0.1 0.22 11.5 0.1 1.9 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family DUF148 PF02520.12 KOO21655.1 - 0.00064 19.4 7.1 0.00064 19.4 4.9 1.8 1 1 1 2 2 2 1 Domain of unknown function DUF148 Macoilin PF09726.4 KOO21655.1 - 0.0066 14.7 12.3 0.0071 14.6 8.5 1.0 1 0 0 1 1 1 1 Transmembrane protein APG6 PF04111.7 KOO21655.1 - 0.055 12.5 17.0 0.072 12.1 11.8 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 zf-His_Me_endon PF05551.6 KOO21655.1 - 0.061 13.3 0.8 0.089 12.7 0.6 1.3 1 0 0 1 1 1 0 Zinc-binding loop region of homing endonuclease CENP-F_leu_zip PF10473.4 KOO21655.1 - 0.44 10.4 15.7 2.5 7.9 1.7 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Occludin_ELL PF07303.8 KOO21655.1 - 0.85 10.3 7.5 25 5.6 0.1 3.1 2 1 1 3 3 3 0 Occludin homology domain Endonuc-BglII PF09195.6 KOO21655.1 - 1.5 8.3 8.2 0.42 10.0 2.0 2.0 1 1 1 2 2 2 0 Restriction endonuclease BglII DUF4201 PF13870.1 KOO21655.1 - 1.9 7.8 21.1 0.44 9.9 4.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) KxDL PF10241.4 KOO21655.1 - 2.1 8.3 11.1 0.17 11.8 0.4 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein IncA PF04156.9 KOO21655.1 - 2.3 7.7 20.1 13 5.3 14.0 1.9 1 1 0 1 1 1 0 IncA protein Nup54 PF13874.1 KOO21655.1 - 2.4 7.8 15.2 0.95 9.1 6.8 2.3 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 DUF2968 PF11180.3 KOO21655.1 - 3 7.1 21.0 5.9 6.2 3.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) FUSC PF04632.7 KOO21655.1 - 3.4 5.9 10.0 3.8 5.8 6.9 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF1664 PF07889.7 KOO21655.1 - 3.7 7.3 5.7 13 5.6 1.3 2.7 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) PDDEXK_1 PF12705.2 KOO21655.1 - 5.2 6.3 8.2 14 4.9 5.7 1.7 1 1 0 1 1 1 0 PD-(D/E)XK nuclease superfamily GAS PF13851.1 KOO21655.1 - 8.5 5.5 19.7 11 5.1 8.9 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Amido_AtzD_TrzD PF09663.5 KOO21656.1 - 0.062 11.8 0.1 0.074 11.6 0.1 1.2 1 0 0 1 1 1 0 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD) TIG PF01833.19 KOO21657.1 - 4.1e-35 119.6 4.6 6.8e-09 35.6 0.5 7.2 6 1 0 6 6 6 6 IPT/TIG domain Myosin_head PF00063.16 KOO21662.1 - 1.3e-189 631.6 0.0 1.6e-189 631.3 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) PH PF00169.24 KOO21662.1 - 2e-13 50.3 0.4 6e-08 32.8 0.1 2.8 2 0 0 2 2 2 2 PH domain PH_11 PF15413.1 KOO21662.1 - 2.4e-07 31.0 0.2 7e-07 29.4 0.1 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain IQ PF00612.22 KOO21662.1 - 0.0088 15.6 13.2 0.16 11.7 0.9 4.0 3 0 0 3 3 3 2 IQ calmodulin-binding motif FERM_N PF09379.5 KOO21662.1 - 0.01 15.8 0.0 0.044 13.8 0.0 2.2 1 0 0 1 1 1 0 FERM N-terminal domain AAA_16 PF13191.1 KOO21662.1 - 0.044 13.7 0.0 0.22 11.4 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain T2SE PF00437.15 KOO21662.1 - 0.06 12.2 0.0 0.12 11.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein YEATS PF03366.11 KOO21663.1 - 4.4e-27 93.6 0.1 6.3e-27 93.1 0.0 1.2 1 0 0 1 1 1 1 YEATS family RINGv PF12906.2 KOO21664.1 - 1.5e-11 44.1 4.7 3.1e-11 43.1 3.3 1.6 1 0 0 1 1 1 1 RING-variant domain DUF179 PF02622.10 KOO21664.1 - 0.00012 21.7 0.0 0.00094 18.8 0.1 2.1 2 0 0 2 2 2 1 Uncharacterized ACR, COG1678 PHD PF00628.24 KOO21664.1 - 0.9 9.2 5.1 2.6 7.8 3.5 1.8 1 1 0 1 1 1 0 PHD-finger TENA_THI-4 PF03070.11 KOO21665.1 - 1e-11 45.0 0.0 1.2e-11 44.7 0.0 1.1 1 0 0 1 1 1 1 TENA/THI-4/PQQC family TIR_2 PF13676.1 KOO21666.1 - 2e-17 63.1 0.2 3.1e-08 33.6 0.0 3.6 3 0 0 3 3 3 2 TIR domain TIR PF01582.15 KOO21666.1 - 0.041 13.3 0.0 5.2 6.5 0.1 2.6 2 0 0 2 2 2 0 TIR domain Arm PF00514.18 KOO21666.1 - 0.054 13.3 15.6 1.2 9.1 0.0 7.8 9 0 0 9 9 9 0 Armadillo/beta-catenin-like repeat Pkinase PF00069.20 KOO21667.1 - 7.1e-50 169.5 0.0 9.8e-50 169.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21667.1 - 3.8e-43 147.4 0.0 6.8e-43 146.6 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO21667.1 - 0.00054 19.0 0.0 0.00084 18.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO21667.1 - 0.005 16.5 0.1 0.015 15.0 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family ADK PF00406.17 KOO21668.1 - 6e-05 22.9 0.0 0.011 15.6 0.0 3.2 3 0 0 3 3 3 1 Adenylate kinase DUF1042 PF06294.6 KOO21668.1 - 0.00092 18.8 0.9 0.042 13.4 0.0 2.5 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1042) ADK_lid PF05191.9 KOO21668.1 - 0.001 18.6 0.0 0.0034 16.9 0.0 1.9 1 0 0 1 1 1 1 Adenylate kinase, active site lid RBM39linker PF15519.1 KOO21668.1 - 0.032 14.4 0.4 0.18 12.1 0.3 2.3 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein DUF2585 PF10755.4 KOO21669.1 - 0.079 12.4 0.1 0.11 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2585) Abhydrolase_6 PF12697.2 KOO21670.1 - 1.1e-21 77.7 8.4 1.2e-21 77.6 5.8 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO21670.1 - 4.9e-11 42.6 0.1 2.8e-10 40.1 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 KOO21670.1 - 2.1e-07 30.8 1.1 3.1e-06 26.9 0.7 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.9 KOO21670.1 - 0.0032 15.9 0.1 0.0044 15.5 0.1 1.2 1 0 0 1 1 1 1 Ndr family Ser_hydrolase PF06821.8 KOO21670.1 - 0.0047 16.5 0.0 0.17 11.4 0.0 2.1 2 0 0 2 2 2 1 Serine hydrolase PGAP1 PF07819.8 KOO21670.1 - 0.0053 16.3 0.0 0.0067 16.0 0.0 1.1 1 0 0 1 1 1 1 PGAP1-like protein Esterase PF00756.15 KOO21670.1 - 0.012 15.0 0.1 0.014 14.8 0.1 1.5 1 1 0 1 1 1 0 Putative esterase Lipase_3 PF01764.20 KOO21670.1 - 0.033 13.8 0.0 0.048 13.2 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Thioesterase PF00975.15 KOO21670.1 - 0.042 14.0 0.1 0.066 13.4 0.1 1.4 1 1 0 1 1 1 0 Thioesterase domain Vps52 PF04129.7 KOO21671.1 - 2.9e-114 382.4 0.0 3.5e-114 382.1 0.0 1.1 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.4 KOO21671.1 - 1.7e-07 29.8 7.3 2.4e-06 26.0 4.3 2.9 3 1 0 3 3 3 1 Exocyst complex component Sec3 COG2 PF06148.6 KOO21671.1 - 0.0012 18.7 1.5 0.0012 18.7 1.0 2.1 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 PF07889.7 KOO21671.1 - 0.18 11.6 2.2 13 5.6 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Complex1_LYR PF05347.10 KOO21672.1 - 1.1e-05 25.1 0.1 1.4e-05 24.7 0.1 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 KOO21672.1 - 4.2e-05 23.6 0.1 5.6e-05 23.2 0.1 1.1 1 0 0 1 1 1 1 Complex1_LYR-like C2 PF00168.25 KOO21673.1 - 1.8e-19 69.3 0.0 2.9e-19 68.6 0.0 1.4 1 0 0 1 1 1 1 C2 domain CH PF00307.26 KOO21673.1 - 6.3e-07 29.4 0.0 9.9e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CDC24 PF06395.6 KOO21673.1 - 0.00096 19.1 0.0 0.0023 17.9 0.0 1.6 2 0 0 2 2 2 1 CDC24 Calponin Aldo_ket_red PF00248.16 KOO21674.1 - 6.4e-66 222.0 0.0 7.8e-66 221.7 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family HHH_5 PF14520.1 KOO21674.1 - 0.081 13.1 0.2 0.44 10.7 0.0 2.3 3 0 0 3 3 3 0 Helix-hairpin-helix domain zf-C2H2_2 PF12756.2 KOO21675.1 - 0.0017 18.4 0.0 0.0023 18.0 0.0 1.1 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.1 KOO21675.1 - 0.031 14.5 0.1 0.054 13.8 0.0 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.21 KOO21675.1 - 0.04 14.2 0.6 0.065 13.6 0.4 1.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type Endonuclease_7 PF02945.10 KOO21675.1 - 0.064 12.9 0.1 0.086 12.5 0.1 1.2 1 0 0 1 1 1 0 Recombination endonuclease VII zf-C2H2_6 PF13912.1 KOO21675.1 - 0.083 12.8 0.1 0.11 12.3 0.1 1.2 1 0 0 1 1 1 0 C2H2-type zinc finger GTP_EFTU PF00009.22 KOO21676.1 - 2e-59 200.1 0.0 3.3e-59 199.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 KOO21676.1 - 4e-38 129.6 0.3 7.2e-38 128.8 0.2 1.4 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.1 KOO21676.1 - 6.1e-33 112.5 0.0 1.2e-32 111.5 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.19 KOO21676.1 - 6.1e-27 93.3 0.2 1.6e-26 91.9 0.1 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 KOO21676.1 - 2.6e-13 49.8 3.2 2.8e-13 49.7 0.5 2.4 3 0 0 3 3 3 1 Elongation factor Tu domain 2 LRR_6 PF13516.1 KOO21677.1 - 0.035 14.1 0.0 0.24 11.5 0.0 2.2 2 0 0 2 2 2 0 Leucine Rich repeat Methyltransf_11 PF08241.7 KOO21678.1 - 3.1e-12 46.8 0.0 6.5e-12 45.7 0.0 1.5 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO21678.1 - 1.4e-07 31.7 0.0 2.5e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO21678.1 - 3.9e-07 29.7 0.0 5.5e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO21678.1 - 2e-06 27.8 1.2 2.1e-06 27.7 0.1 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO21678.1 - 2.6e-06 27.9 0.0 4.5e-06 27.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO21678.1 - 2.8e-06 27.7 0.0 5e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO21678.1 - 1.3e-05 24.9 0.0 1.7e-05 24.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 KOO21678.1 - 0.0023 17.0 0.0 0.0028 16.8 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 KOO21678.1 - 0.02 14.0 0.0 0.063 12.3 0.0 1.7 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family MTS PF05175.9 KOO21678.1 - 0.029 13.7 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.14 KOO21678.1 - 0.068 12.6 0.0 0.09 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) EF-hand_1 PF00036.27 KOO21679.1 - 3.1e-16 57.3 3.5 2e-08 32.9 0.2 2.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO21679.1 - 1.2e-15 56.8 2.2 1e-12 47.4 0.3 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.1 KOO21679.1 - 9.5e-14 51.2 0.3 1.9e-13 50.3 0.2 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO21679.1 - 3e-13 48.4 0.3 6.4e-06 25.6 0.0 3.8 3 1 1 4 4 4 2 EF-hand domain EF-hand_5 PF13202.1 KOO21679.1 - 6e-10 38.0 0.4 0.00027 20.1 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.1 KOO21679.1 - 0.00014 21.6 0.0 0.00031 20.5 0.0 1.6 2 0 0 2 2 2 1 EF-hand domain UPF0154 PF03672.8 KOO21679.1 - 0.00095 18.7 0.1 0.55 9.8 0.0 2.6 2 1 0 2 2 2 2 Uncharacterised protein family (UPF0154) EF-hand_4 PF12763.2 KOO21679.1 - 0.0047 16.6 0.1 0.0092 15.7 0.1 1.6 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand TerB PF05099.8 KOO21679.1 - 0.066 12.9 0.0 0.23 11.1 0.0 1.8 1 1 2 3 3 3 0 Tellurite resistance protein TerB SPARC_Ca_bdg PF10591.4 KOO21679.1 - 0.076 13.0 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO21679.1 - 0.079 12.6 0.2 0.17 11.5 0.1 1.5 1 0 0 1 1 1 0 EF hand EFhand_Ca_insen PF08726.5 KOO21679.1 - 0.11 12.5 0.1 0.25 11.3 0.1 1.6 1 0 0 1 1 1 0 Ca2+ insensitive EF hand TPT PF03151.11 KOO21680.1 - 1.9e-11 43.8 8.9 1.9e-11 43.8 6.2 2.4 2 1 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 KOO21680.1 - 5.7e-09 35.3 18.4 8e-09 34.8 12.7 1.3 1 0 0 1 1 1 1 UAA transporter family DUF3318 PF11780.3 KOO21680.1 - 0.013 15.1 0.5 0.023 14.2 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3318) Chordopox_L2 PF05803.7 KOO21680.1 - 0.12 11.9 2.3 1.1 8.9 0.0 3.1 3 1 0 3 3 3 0 Chordopoxvirus L2 protein 2OG-FeII_Oxy_3 PF13640.1 KOO21682.1 - 5.1e-07 30.1 0.1 9.1e-07 29.3 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily HMG_CoA_synt_N PF01154.12 KOO21683.1 - 2.6e-73 245.2 0.0 4.2e-73 244.5 0.0 1.4 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.5 KOO21683.1 - 2e-65 221.1 0.0 3.5e-65 220.2 0.0 1.3 1 1 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal DDE_Tnp_1_2 PF13586.1 KOO21683.1 - 0.015 15.4 0.0 0.032 14.4 0.0 1.5 1 0 0 1 1 1 0 Transposase DDE domain GHMP_kinases_C PF08544.8 KOO21684.1 - 0.011 15.9 0.7 0.017 15.3 0.5 1.4 1 1 0 1 1 1 0 GHMP kinases C terminal LrgB PF04172.11 KOO21686.1 - 0.036 13.2 0.7 0.23 10.5 0.0 2.1 2 0 0 2 2 2 0 LrgB-like family Auto_anti-p27 PF06677.7 KOO21689.1 - 8.1e-06 25.5 0.5 1.3e-05 24.8 0.1 1.6 2 0 0 2 2 2 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Filamin PF00630.14 KOO21690.1 - 7.7e-61 202.9 1.0 5.4e-17 62.2 0.1 7.4 7 1 0 7 7 7 7 Filamin/ABP280 repeat Big_1 PF02369.11 KOO21690.1 - 4.7e-08 32.8 3.0 0.33 10.8 0.1 4.7 4 0 0 4 4 4 3 Bacterial Ig-like domain (group 1) CarboxypepD_reg PF13620.1 KOO21690.1 - 0.0018 18.2 8.9 1.4 8.9 0.4 4.5 5 0 0 5 5 5 2 Carboxypeptidase regulatory-like domain SH3_3 PF08239.6 KOO21690.1 - 0.039 14.1 0.5 0.16 12.2 0.0 2.2 2 0 0 2 2 2 0 Bacterial SH3 domain Neurexophilin PF06312.7 KOO21690.1 - 0.079 12.1 0.0 8.3 5.5 0.0 2.3 2 0 0 2 2 2 0 Neurexophilin RNA_pol_Rpc4 PF05132.9 KOO21690.1 - 0.12 12.3 4.3 6 6.8 1.9 2.8 3 0 0 3 3 3 0 RNA polymerase III RPC4 YtkA PF13115.1 KOO21690.1 - 9.5 6.6 8.4 25 5.2 0.0 4.9 4 2 0 4 4 4 0 YtkA-like EF-hand_1 PF00036.27 KOO21691.1 - 7.6e-13 46.7 0.6 8.9e-06 24.6 0.0 2.7 2 0 0 2 2 2 2 EF hand ART PF01129.13 KOO21691.1 - 1.6e-10 40.4 1.7 4.3e-08 32.5 0.0 2.4 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase EF-hand_7 PF13499.1 KOO21691.1 - 2.3e-10 40.4 1.6 7.8e-10 38.7 1.1 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO21691.1 - 4.2e-09 35.3 2.3 0.00028 20.1 0.3 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO21691.1 - 1.1e-08 34.5 1.6 0.0043 16.6 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO21691.1 - 3.2e-08 32.7 0.2 0.0071 16.1 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_10 PF14788.1 KOO21691.1 - 0.002 17.7 0.3 0.0052 16.4 0.2 1.8 1 0 0 1 1 1 1 EF hand ADPrib_exo_Tox PF03496.9 KOO21691.1 - 0.0042 16.3 0.0 0.01 15.0 0.0 1.7 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme EF-hand_4 PF12763.2 KOO21691.1 - 0.011 15.4 1.6 1.2 8.8 0.1 2.7 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO21691.1 - 1.5 8.9 7.3 0.1 12.6 0.2 2.5 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Pkinase PF00069.20 KOO21692.1 - 3.6e-56 190.2 0.0 4.6e-56 189.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21692.1 - 3.1e-33 114.9 0.0 1.1e-32 113.1 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO21692.1 - 3.1e-07 29.6 0.0 4.8e-07 29.0 0.0 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO21692.1 - 1.8e-06 27.8 0.4 6e-06 26.1 0.3 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 KOO21692.1 - 0.0039 16.7 0.0 0.014 15.0 0.0 1.8 1 1 0 1 1 1 1 Choline/ethanolamine kinase Kinase-like PF14531.1 KOO21692.1 - 0.0057 15.6 0.0 0.053 12.4 0.0 2.0 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 KOO21692.1 - 0.0073 15.6 0.0 0.016 14.5 0.0 1.5 1 1 0 1 1 1 1 RIO1 family Seadorna_VP7 PF07387.6 KOO21692.1 - 0.047 12.5 0.0 0.069 11.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 SAP PF02037.22 KOO21693.1 - 2.1e-07 30.2 0.3 7e-07 28.6 0.2 1.9 1 0 0 1 1 1 1 SAP domain CBFB_NFYA PF02045.10 KOO21694.1 - 2e-14 53.8 1.5 2.4e-14 53.5 1.0 1.1 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Pkinase PF00069.20 KOO21695.1 - 2.6e-43 148.0 0.0 3.6e-43 147.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21695.1 - 7.4e-19 67.8 0.0 1.2e-18 67.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO21695.1 - 0.0013 18.5 0.0 0.0033 17.1 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 KOO21695.1 - 0.014 14.4 0.3 0.024 13.7 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 KOO21695.1 - 0.079 12.2 0.2 0.13 11.5 0.1 1.3 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.15 KOO21695.1 - 0.14 11.7 0.1 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase ABC_tran PF00005.22 KOO21696.1 - 7.5e-32 110.4 0.0 3.1e-19 69.6 0.0 3.2 3 0 0 3 3 2 2 ABC transporter AAA_21 PF13304.1 KOO21696.1 - 2.9e-16 60.3 0.3 0.00012 22.1 0.0 3.2 3 0 0 3 3 3 3 AAA domain SMC_N PF02463.14 KOO21696.1 - 5.3e-11 42.1 0.0 0.0051 16.0 0.0 3.8 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 KOO21696.1 - 2.6e-09 37.7 6.4 0.0053 17.0 0.0 3.7 4 1 0 4 4 2 2 AAA domain AAA_29 PF13555.1 KOO21696.1 - 3.7e-09 35.9 0.3 0.00029 20.2 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_33 PF13671.1 KOO21696.1 - 5e-07 29.6 0.8 0.0012 18.7 0.0 3.2 3 0 0 3 3 2 2 AAA domain NACHT PF05729.7 KOO21696.1 - 2.5e-06 27.2 0.2 0.094 12.3 0.0 2.7 2 0 0 2 2 2 2 NACHT domain DUF258 PF03193.11 KOO21696.1 - 7.8e-06 25.1 0.1 0.037 13.2 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_17 PF13207.1 KOO21696.1 - 8.9e-06 26.5 2.0 0.024 15.4 0.3 3.6 2 1 0 3 3 2 1 AAA domain RNA_helicase PF00910.17 KOO21696.1 - 2.7e-05 24.2 0.0 0.31 11.2 0.0 3.3 3 0 0 3 3 3 2 RNA helicase AAA_18 PF13238.1 KOO21696.1 - 6.1e-05 23.3 0.0 0.47 10.7 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 KOO21696.1 - 6.6e-05 22.3 2.6 0.62 9.4 0.0 4.1 4 0 0 4 4 4 2 AAA domain AAA_15 PF13175.1 KOO21696.1 - 0.00013 21.1 0.0 4.9 6.0 0.0 3.1 3 0 0 3 3 3 0 AAA ATPase domain AAA PF00004.24 KOO21696.1 - 0.00021 21.5 0.0 0.7 10.0 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOO21696.1 - 0.00023 21.3 0.1 0.65 10.1 0.0 3.2 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 KOO21696.1 - 0.00026 20.9 0.0 1.2 9.0 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 KOO21696.1 - 0.00045 19.9 0.1 0.49 10.1 0.0 3.2 2 0 0 2 2 2 1 Part of AAA domain Rad17 PF03215.10 KOO21696.1 - 0.00063 18.5 0.0 0.59 8.7 0.0 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein DAP3 PF10236.4 KOO21696.1 - 0.00067 18.6 0.1 0.51 9.2 0.0 2.5 2 0 0 2 2 2 2 Mitochondrial ribosomal death-associated protein 3 Arch_ATPase PF01637.13 KOO21696.1 - 0.0015 18.2 0.1 0.65 9.6 0.0 2.9 2 0 0 2 2 2 1 Archaeal ATPase T2SE PF00437.15 KOO21696.1 - 0.0016 17.3 0.3 0.024 13.5 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein MutS_V PF00488.16 KOO21696.1 - 0.002 17.6 0.1 0.26 10.6 0.0 2.3 2 0 0 2 2 2 1 MutS domain V AAA_10 PF12846.2 KOO21696.1 - 0.0021 17.5 0.8 0.93 8.8 0.1 2.6 2 0 0 2 2 2 1 AAA-like domain MMR_HSR1 PF01926.18 KOO21696.1 - 0.0021 18.0 1.4 1.3 9.0 0.1 3.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_24 PF13479.1 KOO21696.1 - 0.0029 17.2 0.0 1.5 8.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.1 KOO21696.1 - 0.0045 16.9 8.1 0.23 11.4 0.0 3.7 3 2 0 3 3 2 2 AAA domain PduV-EutP PF10662.4 KOO21696.1 - 0.0047 16.4 0.2 1.3 8.5 0.0 2.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ABC_tran_2 PF12848.2 KOO21696.1 - 0.006 16.4 0.0 0.006 16.4 0.0 3.8 3 1 0 3 3 2 1 ABC transporter AAA_5 PF07728.9 KOO21696.1 - 0.0063 16.2 3.8 1.1 8.9 0.1 3.2 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) G-alpha PF00503.15 KOO21696.1 - 0.008 14.9 0.3 3 6.4 0.0 2.4 2 0 0 2 2 2 1 G-protein alpha subunit NTPase_1 PF03266.10 KOO21696.1 - 0.01 15.5 0.6 4.4 6.9 0.0 2.9 3 0 0 3 3 2 0 NTPase Zeta_toxin PF06414.7 KOO21696.1 - 0.01 14.9 0.4 0.52 9.3 0.0 3.0 2 0 0 2 2 2 0 Zeta toxin IstB_IS21 PF01695.12 KOO21696.1 - 0.012 15.0 0.6 1.8 7.9 0.0 3.2 3 0 0 3 3 3 0 IstB-like ATP binding protein Mg_chelatase PF01078.16 KOO21696.1 - 0.013 14.6 3.0 0.14 11.3 0.0 2.8 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.8 KOO21696.1 - 0.016 14.1 0.2 1.2 7.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Miro PF08477.8 KOO21696.1 - 0.017 15.6 0.3 10 6.6 0.0 3.2 3 0 0 3 3 3 0 Miro-like protein ArgK PF03308.11 KOO21696.1 - 0.026 13.3 0.4 0.25 10.1 0.0 2.4 2 0 0 2 2 2 0 ArgK protein AAA_16 PF13191.1 KOO21696.1 - 0.055 13.4 15.9 0.2 11.6 0.1 4.0 3 3 1 4 4 3 0 AAA ATPase domain UPF0079 PF02367.12 KOO21696.1 - 0.059 13.0 0.9 0.51 9.9 0.1 2.3 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 cobW PF02492.14 KOO21696.1 - 0.064 12.6 4.0 3.1 7.2 0.0 3.7 3 1 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.18 KOO21696.1 - 0.076 12.8 2.1 5.5 6.7 0.0 3.3 4 0 0 4 4 3 0 Dynamin family ATP-synt_ab PF00006.20 KOO21696.1 - 0.076 12.5 0.4 5.5 6.4 0.0 2.7 3 0 0 3 3 2 0 ATP synthase alpha/beta family, nucleotide-binding domain VirE PF05272.6 KOO21696.1 - 0.1 12.0 0.4 2.5 7.5 0.0 2.6 3 0 0 3 3 2 0 Virulence-associated protein E Viral_helicase1 PF01443.13 KOO21696.1 - 0.13 11.7 0.1 8.1 5.8 0.1 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Guanylate_kin PF00625.16 KOO21696.1 - 0.25 10.7 2.4 1.5 8.2 0.0 2.8 3 0 0 3 3 3 0 Guanylate kinase EF-hand_5 PF13202.1 KOO21697.1 - 0.0087 15.3 0.1 0.019 14.3 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KOO21697.1 - 0.019 14.2 0.1 0.036 13.3 0.1 1.5 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.1 KOO21697.1 - 0.054 13.3 0.0 0.16 11.9 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain LRR_6 PF13516.1 KOO21698.1 - 0.00076 19.3 0.0 0.00099 18.9 0.0 1.2 1 0 0 1 1 1 1 Leucine Rich repeat PAN_4 PF14295.1 KOO21699.1 - 2.3e-14 52.8 5.4 2.5e-08 33.5 0.2 2.9 2 1 0 2 2 2 2 PAN domain PAN_1 PF00024.21 KOO21699.1 - 3.9e-14 52.1 0.1 2.2e-07 30.5 0.0 2.3 2 0 0 2 2 2 2 PAN domain PAN_2 PF08276.6 KOO21699.1 - 0.035 13.9 2.4 0.14 12.0 0.1 2.3 2 0 0 2 2 2 0 PAN-like domain ELMO_CED12 PF04727.8 KOO21700.1 - 2.6e-25 88.9 0.0 3.7e-25 88.4 0.0 1.3 1 0 0 1 1 1 1 ELMO/CED-12 family EF-hand_1 PF00036.27 KOO21701.1 - 1.3e-16 58.5 0.0 0.0021 17.2 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO21701.1 - 1.9e-13 49.0 0.0 0.045 13.6 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO21701.1 - 5e-12 45.7 0.0 0.00024 21.1 0.0 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO21701.1 - 3.1e-10 38.8 3.7 0.017 14.4 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO21701.1 - 0.00089 18.8 0.7 9.2 5.9 0.0 4.3 5 0 0 5 5 5 1 EF-hand domain pair zf-RING_2 PF13639.1 KOO21701.1 - 0.029 14.2 0.0 0.057 13.2 0.0 1.5 1 0 0 1 1 1 0 Ring finger domain 2Fe-2S_thioredx PF01257.14 KOO21702.1 - 0.00013 21.6 0.7 0.00013 21.5 0.5 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin XPG_N PF00752.12 KOO21703.1 - 4.4e-30 103.9 0.0 8.1e-30 103.0 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.13 KOO21703.1 - 1.7e-26 92.0 0.9 3.4e-26 91.1 0.0 1.9 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.15 KOO21703.1 - 4e-08 33.3 0.1 2.7e-07 30.7 0.0 2.3 2 1 1 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.1 KOO21703.1 - 0.00076 19.6 0.4 0.003 17.6 0.0 2.2 3 0 0 3 3 3 1 Helix-hairpin-helix domain 5_3_exonuc_N PF02739.11 KOO21703.1 - 0.0082 15.5 0.0 0.049 13.0 0.0 2.0 1 1 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain DUF106 PF01956.11 KOO21703.1 - 1.1 8.8 3.3 0.99 8.9 0.8 1.9 2 0 0 2 2 2 0 Integral membrane protein DUF106 DnaJ PF00226.26 KOO21704.1 - 5.2e-27 93.3 4.9 7.7e-27 92.8 3.4 1.3 1 0 0 1 1 1 1 DnaJ domain Fork_head_N PF08430.7 KOO21704.1 - 0.072 13.4 13.7 0.16 12.3 9.5 1.7 1 0 0 1 1 1 0 Forkhead N-terminal region NAPRTase PF04095.11 KOO21705.1 - 3e-66 223.1 0.0 3.7e-66 222.8 0.0 1.1 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family zf-Tim10_DDP PF02953.10 KOO21706.1 - 1.9e-21 75.1 2.0 2.3e-21 74.8 1.4 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.8 KOO21706.1 - 0.087 12.2 2.3 0.1 12.0 1.6 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) Pkinase PF00069.20 KOO21707.1 - 1e-51 175.5 0.0 1.9e-51 174.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.24 KOO21707.1 - 1.1e-28 98.8 0.1 2.6e-14 52.8 0.0 3.1 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.12 KOO21707.1 - 4.8e-27 94.6 0.0 8.3e-27 93.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.14 KOO21707.1 - 5.8e-12 45.7 0.0 1.8e-11 44.1 0.0 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain GRAM PF02893.15 KOO21707.1 - 0.0038 16.7 0.0 0.0073 15.7 0.0 1.5 1 0 0 1 1 1 1 GRAM domain Kdo PF06293.9 KOO21707.1 - 0.0052 15.8 0.1 0.011 14.8 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 KOO21707.1 - 0.014 14.3 0.0 0.026 13.5 0.0 1.4 1 0 0 1 1 1 0 Kinase-like PIP49_C PF12260.3 KOO21707.1 - 0.042 13.2 1.4 4 6.8 0.0 3.1 2 1 0 3 3 3 0 Protein-kinase domain of FAM69 DUF179 PF02622.10 KOO21708.1 - 7.8e-11 41.8 0.0 3.3e-10 39.8 0.0 1.9 2 0 0 2 2 2 1 Uncharacterized ACR, COG1678 Cyt-b5 PF00173.23 KOO21709.1 - 2.7e-11 43.0 0.0 3.9e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain SecA_DEAD PF07517.9 KOO21711.1 - 3e-09 36.5 0.0 1.3e-08 34.4 0.0 2.1 1 0 0 1 1 1 1 SecA DEAD-like domain DnaJ PF00226.26 KOO21711.1 - 1.1e-08 34.7 0.2 2.8e-08 33.3 0.1 1.8 1 0 0 1 1 1 1 DnaJ domain MMR_HSR1 PF01926.18 KOO21711.1 - 0.012 15.5 0.0 0.037 14.0 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.22 KOO21711.1 - 0.034 14.4 0.0 0.28 11.4 0.0 2.7 2 0 0 2 2 2 0 ABC transporter AAA_29 PF13555.1 KOO21711.1 - 0.079 12.4 0.7 1.3 8.6 0.1 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain DUF258 PF03193.11 KOO21711.1 - 0.081 12.1 0.0 0.18 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 EF-hand_1 PF00036.27 KOO21712.1 - 2.2e-12 45.2 2.7 2.7e-05 23.1 0.2 2.2 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO21712.1 - 1.5e-11 44.2 0.1 2e-11 43.8 0.1 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO21712.1 - 5.6e-11 41.3 0.1 1.2e-05 24.7 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO21712.1 - 2.4e-09 36.0 0.5 0.00015 20.9 0.2 2.2 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO21712.1 - 4.3e-08 32.6 1.9 4.2e-05 23.0 0.1 2.1 1 1 1 2 2 2 2 EF-hand domain pair DUF3126 PF11324.3 KOO21712.1 - 0.076 12.6 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3126) Brix PF04427.13 KOO21714.1 - 7e-16 58.4 0.0 8.6e-16 58.1 0.0 1.0 1 0 0 1 1 1 1 Brix domain AMP-binding PF00501.23 KOO21715.1 - 1.4e-89 300.3 0.0 1.8e-89 300.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme PAP_central PF04928.12 KOO21716.1 - 5.6e-78 261.2 0.0 7.4e-78 260.8 0.0 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain His_Phos_1 PF00300.17 KOO21716.1 - 2e-07 31.2 0.1 6.5e-07 29.5 0.0 1.8 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) PAP_RNA-bind PF04926.10 KOO21716.1 - 4.2e-05 23.1 0.0 0.0001 21.8 0.0 1.6 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.18 KOO21716.1 - 0.0025 18.1 0.0 0.0058 16.9 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Semialdhyde_dh PF01118.19 KOO21717.1 - 1e-14 54.8 0.5 1.8e-12 47.5 0.1 3.1 2 1 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain F420_oxidored PF03807.12 KOO21717.1 - 0.016 15.5 1.7 0.017 15.5 0.1 1.8 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.13 KOO21717.1 - 0.038 13.9 0.2 0.094 12.7 0.1 1.7 1 0 0 1 1 1 0 TrkA-N domain PFK PF00365.15 KOO21718.1 - 6.6e-22 77.7 0.8 1.2e-21 76.9 0.1 1.7 2 1 0 2 2 2 1 Phosphofructokinase FA_hydroxylase PF04116.8 KOO21719.1 - 1.9e-11 44.3 17.4 2.9e-11 43.7 12.1 1.3 1 1 0 1 1 1 1 Fatty acid hydroxylase superfamily Transp_cyt_pur PF02133.10 KOO21719.1 - 0.016 13.7 1.1 0.018 13.6 0.8 1.1 1 0 0 1 1 1 0 Permease for cytosine/purines, uracil, thiamine, allantoin MFS_1 PF07690.11 KOO21720.1 - 2.8e-39 134.8 12.8 2.6e-25 88.9 1.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KOO21720.1 - 9.5e-06 24.2 26.6 0.00027 19.4 1.3 3.0 2 2 1 3 3 3 2 MFS/sugar transport protein Multi_Drug_Res PF00893.14 KOO21720.1 - 0.009 16.4 0.8 0.009 16.4 0.5 3.5 3 1 1 4 4 4 1 Small Multidrug Resistance protein ATG22 PF11700.3 KOO21720.1 - 0.51 8.7 21.2 0.066 11.6 0.6 3.9 2 2 1 3 3 3 0 Vacuole effluxer Atg22 like Aldo_ket_red PF00248.16 KOO21721.1 - 2.3e-43 148.0 0.0 2.8e-43 147.7 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family 2OG-FeII_Oxy_3 PF13640.1 KOO21722.1 - 5.4e-07 30.0 0.0 9.7e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO21722.1 - 0.00025 20.6 0.0 0.00054 19.5 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily EF-hand_6 PF13405.1 KOO21723.1 - 7.5e-13 47.2 0.0 3.6e-05 23.2 0.0 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO21723.1 - 2.4e-12 45.1 0.2 1.5e-05 23.9 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO21723.1 - 2.6e-09 37.0 0.0 1.4e-08 34.7 0.0 2.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO21723.1 - 2.6e-08 32.8 0.7 6.5e-05 22.1 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO21723.1 - 4.6e-08 32.5 0.4 1.2e-05 24.8 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain pair ApoO PF09769.4 KOO21723.1 - 4.2 7.0 11.3 0.08 12.6 0.8 3.5 3 0 0 3 3 3 0 Apolipoprotein O Sec23_BS PF08033.7 KOO21724.1 - 3.4e-13 49.8 0.0 8.4e-13 48.6 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain T2SI PF02501.12 KOO21724.1 - 2.3e-11 43.4 1.3 16 5.5 0.0 8.1 3 2 5 8 8 8 1 Type II secretion system (T2SS), protein I DUF3935 PF13071.1 KOO21724.1 - 6.2e-09 36.1 0.0 10 6.6 0.0 8.6 10 0 0 10 10 10 1 Protein of unknown function (DUF3935) Sec23_helical PF04815.10 KOO21724.1 - 0.00031 20.1 0.1 0.00063 19.1 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain DUF4160 PF13711.1 KOO21724.1 - 0.0023 17.7 0.0 5.7 6.8 0.0 5.1 7 0 0 7 7 7 1 Domain of unknown function (DUF4160) BAMBI PF06211.7 KOO21724.1 - 0.0038 17.1 0.0 0.016 15.2 0.0 2.0 1 0 0 1 1 1 1 BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain Sec23_trunk PF04811.10 KOO21724.1 - 0.061 12.6 0.0 0.22 10.8 0.0 1.9 1 1 0 1 1 1 0 Sec23/Sec24 trunk domain DUF2587 PF10759.4 KOO21724.1 - 0.29 10.4 1.5 0.33 10.3 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2587) Tubulin PF00091.20 KOO21725.1 - 4.8e-59 199.7 0.0 7.7e-59 199.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 KOO21725.1 - 2e-45 153.9 0.1 8.1e-45 151.9 0.0 2.0 1 1 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.1 KOO21725.1 - 0.065 12.1 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Tubulin like Ank_2 PF12796.2 KOO21726.1 - 6.4e-18 64.8 0.0 2.9e-09 37.1 0.0 2.4 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO21726.1 - 1.3e-14 53.1 1.0 2e-07 30.4 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 KOO21726.1 - 1.8e-12 47.0 0.1 1e-07 31.9 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO21726.1 - 1.8e-10 39.9 0.2 4.8e-06 26.2 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOO21726.1 - 2e-09 37.7 0.0 9.7e-08 32.3 0.0 2.6 1 1 1 2 2 2 1 Ankyrin repeats (many copies) EF-hand_6 PF13405.1 KOO21726.1 - 1.3e-05 24.7 0.5 0.0049 16.6 0.1 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.1 KOO21726.1 - 4.4e-05 22.6 1.0 0.00044 19.4 0.4 2.4 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO21726.1 - 0.00081 19.4 2.8 0.031 14.4 0.2 2.0 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO21726.1 - 0.0014 17.7 1.1 0.0034 16.5 0.1 2.1 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.1 KOO21726.1 - 0.066 12.8 0.1 0.26 10.9 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain pair E2F_TDP PF02319.15 KOO21727.1 - 1.9e-35 120.2 0.0 5.9e-17 61.0 0.0 2.4 2 0 0 2 2 2 2 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.14 KOO21727.1 - 0.0077 15.9 0.1 0.032 13.9 0.0 2.0 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB ZF-HD_dimer PF04770.7 KOO21728.1 - 0.13 12.3 0.8 0.13 12.3 0.6 1.8 2 0 0 2 2 2 0 ZF-HD protein dimerisation region Herpes_capsid PF06112.6 KOO21728.1 - 8.3 6.4 6.9 12 5.9 4.8 1.4 1 1 0 1 1 1 0 Gammaherpesvirus capsid protein LRR_6 PF13516.1 KOO21729.1 - 7.1e-20 68.8 19.8 0.72 10.1 0.1 15.0 16 0 0 16 16 16 5 Leucine Rich repeat LRR_1 PF00560.28 KOO21729.1 - 6.1e-09 34.6 11.4 1.1 9.5 0.0 10.8 13 0 0 13 13 13 2 Leucine Rich Repeat LRR_4 PF12799.2 KOO21729.1 - 7.5e-08 31.8 15.8 0.77 9.4 0.0 8.6 9 1 0 9 9 9 4 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO21729.1 - 1.4e-07 30.5 11.3 3.8 8.1 0.1 11.0 13 0 0 13 13 13 1 Leucine rich repeat LRR_8 PF13855.1 KOO21729.1 - 0.0003 20.4 14.0 18 5.1 0.7 8.6 8 2 0 8 8 8 0 Leucine rich repeat Skp1 PF01466.14 KOO21729.1 - 0.00044 20.2 0.0 0.0013 18.7 0.0 1.8 1 0 0 1 1 1 1 Skp1 family, dimerisation domain DUF2839 PF10999.3 KOO21729.1 - 0.05 13.6 0.0 9.9 6.2 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2839) Mg_chelatase_2 PF13335.1 KOO21729.1 - 0.071 13.5 0.1 4.9 7.6 0.0 2.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ATP1G1_PLM_MAT8 PF02038.11 KOO21729.1 - 3.7 6.6 4.8 29 3.7 0.2 2.7 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family DUF2422 PF10337.4 KOO21730.1 - 1.9 7.1 3.7 3 6.5 2.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) DUF3584 PF12128.3 KOO21730.1 - 3.9 4.6 22.0 5.6 4.1 15.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ERM PF00769.14 KOO21730.1 - 5.8 6.3 35.6 1.4 8.3 20.7 2.3 2 0 0 2 2 2 0 Ezrin/radixin/moesin family DDE_Tnp_ISL3 PF01610.12 KOO21730.1 - 5.9 6.3 7.8 9.4 5.7 5.4 1.2 1 0 0 1 1 1 0 Transposase Atg14 PF10186.4 KOO21730.1 - 6.7 5.5 10.9 12 4.7 7.6 1.4 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 BNR PF02012.15 KOO21731.1 - 6.1e-07 28.3 2.7 1.2 9.2 0.0 5.1 4 0 0 4 4 4 3 BNR/Asp-box repeat BNR_2 PF13088.1 KOO21731.1 - 0.00033 20.0 3.7 0.78 8.9 0.1 4.1 2 2 0 2 2 2 2 BNR repeat-like domain DUF523 PF04463.7 KOO21731.1 - 0.13 12.0 0.8 0.24 11.1 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF523) Galactosyl_T PF01762.16 KOO21732.1 - 3e-05 23.7 0.0 7.8e-05 22.3 0.0 1.7 1 1 0 1 1 1 1 Galactosyltransferase Ofd1_CTDD PF10637.4 KOO21733.1 - 8.1e-48 162.8 0.0 2.6e-39 134.9 0.0 3.2 2 1 1 3 3 3 3 Oxoglutarate and iron-dependent oxygenase degradation C-term WW PF00397.21 KOO21735.1 - 3.2e-24 84.4 21.6 3e-06 26.9 1.6 4.9 5 0 0 5 5 5 4 WW domain Peptidase_S28 PF05577.7 KOO21736.1 - 5.4e-48 163.6 0.4 7.3e-35 120.3 0.0 2.4 1 1 1 2 2 2 2 Serine carboxypeptidase S28 Abhydrolase_6 PF12697.2 KOO21736.1 - 3.1e-06 27.2 0.8 1.9e-05 24.6 0.5 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO21736.1 - 0.0091 15.7 0.0 0.065 12.9 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S37 PF05576.6 KOO21736.1 - 0.016 13.6 0.0 0.087 11.2 0.0 2.1 2 1 0 2 2 2 0 PS-10 peptidase S37 Abhydrolase_1 PF00561.15 KOO21736.1 - 0.041 13.4 0.1 0.33 10.4 0.1 2.0 2 0 0 2 2 2 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 KOO21736.1 - 0.061 12.5 0.1 0.091 11.9 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Ank_2 PF12796.2 KOO21737.1 - 2.8e-98 322.4 66.0 1.2e-18 67.2 0.7 6.7 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO21737.1 - 3.4e-46 154.8 18.5 1.3e-09 38.3 0.0 9.1 6 2 3 10 10 10 7 Ankyrin repeats (many copies) Ank PF00023.25 KOO21737.1 - 1.6e-45 150.7 64.5 1.9e-06 27.3 0.2 13.5 13 0 0 13 13 13 12 Ankyrin repeat Ank_5 PF13857.1 KOO21737.1 - 1.7e-41 139.3 48.4 2.2e-08 34.0 0.3 11.7 1 1 11 12 12 12 11 Ankyrin repeats (many copies) Pkinase PF00069.20 KOO21737.1 - 8.4e-31 107.0 0.0 1.6e-30 106.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ank_3 PF13606.1 KOO21737.1 - 1.5e-25 86.6 30.9 0.00025 20.9 0.0 12.1 11 0 0 11 11 11 9 Ankyrin repeat Pkinase_Tyr PF07714.12 KOO21737.1 - 7e-25 87.5 0.0 1.2e-24 86.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4182 PF13790.1 KOO21737.1 - 3e-06 26.9 13.6 0.73 9.6 0.0 7.9 9 0 0 9 9 9 2 Domain of unknown function (DUF4182) LIN37 PF15306.1 KOO21737.1 - 0.008 16.1 0.1 1.7e+02 2.1 0.0 6.4 9 0 0 9 9 9 0 LIN37 Kinase-like PF14531.1 KOO21737.1 - 0.2 10.5 0.0 0.64 8.9 0.0 1.8 1 0 0 1 1 1 0 Kinase-like Kinesin PF00225.18 KOO21738.1 - 9.7e-22 77.1 0.0 2.4e-21 75.8 0.0 1.6 2 0 0 2 2 2 1 Kinesin motor domain TPR_12 PF13424.1 KOO21738.1 - 6.6e-11 41.9 1.6 7.2e-09 35.4 1.1 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO21738.1 - 8.6e-06 25.1 0.9 0.0017 17.9 0.0 3.3 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_10 PF13374.1 KOO21738.1 - 4.4e-05 23.2 0.8 0.013 15.4 0.3 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOO21738.1 - 0.001 18.6 5.6 0.0018 17.8 1.1 3.1 2 1 1 3 3 3 2 TPR repeat TPR_2 PF07719.12 KOO21738.1 - 0.077 12.9 7.4 0.25 11.3 0.2 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOO21738.1 - 0.16 11.8 5.7 4.5 7.2 1.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat LMBR1 PF04791.11 KOO21738.1 - 0.17 10.4 2.1 0.28 9.7 1.5 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein TPR_1 PF00515.23 KOO21738.1 - 0.25 10.9 9.4 1.8 8.3 0.2 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat V_ATPase_I PF01496.14 KOO21738.1 - 0.31 8.8 6.0 0.58 7.9 4.1 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NPV_P10 PF05531.7 KOO21738.1 - 0.42 10.8 3.8 17 5.7 0.3 3.3 2 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.7 KOO21738.1 - 1.5 8.6 3.8 15 5.3 2.6 2.3 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_16 PF13432.1 KOO21738.1 - 2.3 9.0 9.6 0.06 14.0 1.4 2.5 2 0 0 2 2 1 0 Tetratricopeptide repeat TMCO5 PF14992.1 KOO21738.1 - 3.3 6.7 11.8 6.1 5.8 8.1 1.4 1 0 0 1 1 1 0 TMCO5 family TMPIT PF07851.8 KOO21738.1 - 9 5.2 5.6 19 4.1 3.9 1.5 1 0 0 1 1 1 0 TMPIT-like protein Porphobil_deam PF01379.15 KOO21739.1 - 1.8e-76 255.8 0.0 2.3e-76 255.4 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.10 KOO21739.1 - 2.3e-18 66.0 0.3 4.4e-18 65.1 0.2 1.5 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Pkinase PF00069.20 KOO21741.1 - 1.3e-60 204.7 0.0 2.2e-60 204.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.24 KOO21741.1 - 9.9e-36 121.4 0.0 3.9e-17 61.8 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.12 KOO21741.1 - 7.3e-28 97.3 0.0 1.2e-27 96.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO21741.1 - 1.5e-06 27.4 0.0 1.4e-05 24.2 0.0 2.0 1 1 1 2 2 2 1 Kinase-like bZIP_1 PF00170.16 KOO21741.1 - 0.25 11.3 4.0 0.49 10.3 2.8 1.5 1 0 0 1 1 1 0 bZIP transcription factor TerD PF02342.13 KOO21742.1 - 3e-63 212.5 0.0 1.2e-33 115.9 0.0 2.1 2 0 0 2 2 2 2 TerD domain C2 PF00168.25 KOO21742.1 - 7.7e-13 48.1 0.0 1.3e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 C2 domain RRM_1 PF00076.17 KOO21743.1 - 3.9e-20 71.2 0.0 1.3e-10 40.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO21743.1 - 6.6e-16 58.0 0.0 8.6e-08 32.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO21743.1 - 1.5e-11 43.9 0.0 2.3e-06 27.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Thymidylat_synt PF00303.14 KOO21746.1 - 0.17 10.8 0.0 0.26 10.2 0.0 1.2 1 0 0 1 1 1 0 Thymidylate synthase Pkinase PF00069.20 KOO21747.1 - 3.5e-59 200.0 0.0 4.5e-59 199.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21747.1 - 3e-26 92.0 0.0 7.8e-26 90.6 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO21747.1 - 0.00086 19.1 0.7 0.0032 17.2 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO21747.1 - 0.23 10.4 0.0 0.47 9.3 0.0 1.6 1 1 0 1 1 1 0 Kinase-like Herpes_UL87 PF03043.9 KOO21748.1 - 0.21 9.9 0.5 3.4 5.9 0.0 2.7 2 1 0 2 2 2 0 Herpesvirus UL87 family Nucleotid_trans PF03407.11 KOO21749.1 - 5e-13 49.3 0.0 8e-13 48.6 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Nucleotid_trans PF03407.11 KOO21750.1 - 8.2e-10 38.8 0.5 1.2e-09 38.3 0.4 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Mito_carr PF00153.22 KOO21751.1 - 3.6e-21 74.6 7.9 2.9e-08 33.2 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Glyco_trans_1_4 PF13692.1 KOO21753.1 - 2.5e-08 34.1 0.0 5.4e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 KOO21753.1 - 0.0002 21.5 0.0 0.00051 20.2 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.15 KOO21753.1 - 0.0005 19.5 0.0 0.0019 17.6 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferases group 1 Flavi_capsid PF01003.14 KOO21754.1 - 0.012 15.1 0.2 0.021 14.3 0.1 1.3 1 0 0 1 1 1 0 Flavivirus capsid protein C Acetyltransf_1 PF00583.19 KOO21754.1 - 0.056 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family DUF1802 PF08819.6 KOO21754.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1802) DEC-1_N PF04625.8 KOO21754.1 - 0.19 10.3 3.4 0.061 11.9 0.4 1.6 2 0 0 2 2 2 0 DEC-1 protein, N-terminal region Ndc80_HEC PF03801.8 KOO21755.1 - 6.4e-11 41.9 0.0 1.2e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 HEC/Ndc80p family AAA_13 PF13166.1 KOO21755.1 - 0.00013 20.6 5.1 0.00013 20.6 3.5 2.0 2 0 0 2 2 2 2 AAA domain GAS PF13851.1 KOO21755.1 - 0.0014 17.9 12.7 0.0014 17.9 8.8 3.4 2 1 1 3 3 3 2 Growth-arrest specific micro-tubule binding DUF3584 PF12128.3 KOO21755.1 - 0.013 12.8 36.7 0.051 10.9 9.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Filament PF00038.16 KOO21755.1 - 0.063 12.7 44.0 0.014 14.8 14.3 4.1 2 2 1 3 3 3 0 Intermediate filament protein FlaC_arch PF05377.6 KOO21755.1 - 0.21 11.5 9.8 37 4.3 0.1 5.2 4 2 0 4 4 4 0 Flagella accessory protein C (FlaC) Reo_sigmaC PF04582.7 KOO21755.1 - 0.45 9.6 4.3 0.15 11.2 0.7 1.9 2 0 0 2 2 2 0 Reovirus sigma C capsid protein HALZ PF02183.13 KOO21755.1 - 1.2 8.8 9.4 0.89 9.3 0.2 4.0 3 0 0 3 3 3 0 Homeobox associated leucine zipper Gp58 PF07902.6 KOO21755.1 - 1.5 6.9 15.2 0.31 9.2 0.3 2.5 2 1 1 3 3 3 0 gp58-like protein RasGAP_C PF03836.10 KOO21755.1 - 2.7 7.6 0.0 2.7 7.6 0.0 3.8 3 1 0 3 3 3 0 RasGAP C-terminus EF-hand_1 PF00036.27 KOO21756.1 - 8.1e-10 37.2 3.9 0.00039 19.5 0.2 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO21756.1 - 3.6e-09 36.6 0.3 1.2e-08 34.9 0.2 1.9 1 0 0 1 1 1 1 EF-hand domain pair cNMP_binding PF00027.24 KOO21756.1 - 2.4e-08 33.6 0.0 0.00081 19.1 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain EF-hand_8 PF13833.1 KOO21756.1 - 1.5e-07 30.8 0.1 1.5e-07 30.8 0.1 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO21756.1 - 5.5e-07 28.9 3.0 0.0002 20.9 0.2 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO21756.1 - 2.8e-06 26.4 4.0 0.0068 15.7 0.5 2.9 3 0 0 3 3 3 2 EF hand Nop53 PF07767.6 KOO21757.1 - 5.8e-33 114.4 20.8 3.8e-32 111.7 14.3 2.0 1 1 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) CDC45 PF02724.9 KOO21757.1 - 1.2 7.1 15.6 1.7 6.5 10.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DAGK_cat PF00781.19 KOO21758.1 - 1.6e-25 89.0 0.4 2.6e-25 88.3 0.3 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Ank PF00023.25 KOO21759.1 - 3.4e-19 67.6 0.1 2e-09 36.7 0.1 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 KOO21759.1 - 8.9e-16 57.9 0.0 1e-09 38.6 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO21759.1 - 1.1e-15 57.7 0.2 7.1e-15 55.1 0.2 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO21759.1 - 3.1e-14 52.6 0.3 8.2e-07 29.0 0.1 2.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO21759.1 - 1.1e-11 43.7 0.0 0.0004 20.3 0.0 3.7 3 1 1 4 4 4 2 Ankyrin repeat TPR_16 PF13432.1 KOO21760.1 - 1.9e-26 92.1 51.1 5.1e-07 30.1 3.1 8.2 4 2 5 9 9 9 8 Tetratricopeptide repeat TPR_11 PF13414.1 KOO21760.1 - 1.9e-19 69.0 24.1 3.1e-09 36.3 0.3 7.1 6 2 1 7 7 7 4 TPR repeat TPR_14 PF13428.1 KOO21760.1 - 3.7e-19 67.4 59.5 3e-06 27.3 0.2 11.5 4 3 10 14 14 14 7 Tetratricopeptide repeat TPR_2 PF07719.12 KOO21760.1 - 2.3e-18 64.5 40.1 0.0011 18.7 0.4 10.8 11 1 1 12 12 12 6 Tetratricopeptide repeat TPR_17 PF13431.1 KOO21760.1 - 8.1e-17 59.9 13.4 0.044 13.9 0.0 8.6 10 0 0 10 10 8 4 Tetratricopeptide repeat TPR_12 PF13424.1 KOO21760.1 - 7.3e-16 57.8 36.1 3.8e-06 26.7 0.3 8.1 3 3 5 9 9 9 6 Tetratricopeptide repeat TPR_19 PF14559.1 KOO21760.1 - 2.8e-13 49.9 28.1 0.0071 16.6 0.1 7.8 4 4 3 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.1 KOO21760.1 - 3.5e-13 48.2 1.1 0.29 10.9 0.0 7.1 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO21760.1 - 5.5e-12 44.7 9.4 0.015 14.8 0.0 6.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.1 KOO21760.1 - 1.7e-11 43.0 19.2 0.012 15.3 0.1 8.3 8 1 1 9 9 9 3 Tetratricopeptide repeat TPR_15 PF13429.1 KOO21760.1 - 8e-08 31.6 9.2 8e-08 31.6 6.4 3.2 1 1 1 2 2 2 1 Tetratricopeptide repeat FAT PF02259.18 KOO21760.1 - 0.0024 16.9 4.0 0.23 10.4 0.1 3.5 3 1 0 3 3 3 1 FAT domain TPR_6 PF13174.1 KOO21760.1 - 0.015 15.6 22.4 8.8 7.0 0.4 9.2 8 2 1 9 9 9 0 Tetratricopeptide repeat DUF591 PF04569.9 KOO21760.1 - 0.024 14.6 0.5 0.024 14.6 0.4 2.2 2 0 0 2 2 1 0 Protein of unknown function DUF3366 PF11846.3 KOO21760.1 - 0.041 13.7 0.4 0.041 13.7 0.3 3.4 1 1 2 4 4 4 0 Domain of unknown function (DUF3366) Fis1_TPR_C PF14853.1 KOO21760.1 - 0.055 13.3 2.1 3.5 7.5 0.0 4.0 3 1 1 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.1 KOO21760.1 - 0.061 13.4 4.5 14 5.8 0.0 4.2 3 2 1 4 4 4 0 Tetratricopeptide repeat ChAPs PF09295.5 KOO21760.1 - 0.11 11.2 0.2 6.6 5.3 0.0 2.2 2 0 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_9 PF13371.1 KOO21760.1 - 0.53 10.1 31.4 0.79 9.6 0.6 6.3 3 1 3 6 6 6 0 Tetratricopeptide repeat DUF1465 PF07323.7 KOO21760.1 - 0.92 9.0 6.0 3.9 7.0 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1465) TPR_21 PF09976.4 KOO21760.1 - 3.2 7.7 15.1 1.8 8.5 0.0 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat OAD_gamma PF04277.8 KOO21761.1 - 0.041 14.2 0.1 0.069 13.5 0.1 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Bac_surface_Ag PF01103.18 KOO21762.1 - 1.9e-33 116.2 0.0 2.5e-33 115.9 0.0 1.1 1 0 0 1 1 1 1 Surface antigen Tic22 PF04278.7 KOO21763.1 - 0.00026 20.3 0.0 0.00029 20.2 0.0 1.1 1 0 0 1 1 1 1 Tic22-like family DUF3638 PF12340.3 KOO21764.1 - 3.7e-28 98.0 0.1 7.8e-28 97.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.3 KOO21764.1 - 2.8e-17 61.5 0.1 1.2e-15 56.3 0.1 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3645) DEAD PF00270.24 KOO21764.1 - 0.03 13.7 0.0 0.068 12.6 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase Prefoldin_2 PF01920.15 KOO21764.1 - 0.032 14.0 4.7 0.13 12.0 0.1 3.7 3 1 1 4 4 4 0 Prefoldin subunit Laminin_G_3 PF13385.1 KOO21766.1 - 0.0012 19.1 0.0 0.002 18.3 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF1183 PF06682.7 KOO21766.1 - 3.1 7.3 5.6 5.4 6.5 3.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) DnaJ PF00226.26 KOO21767.1 - 1.8e-24 85.2 2.0 1.8e-24 85.2 1.4 2.3 2 0 0 2 2 2 1 DnaJ domain TPR_11 PF13414.1 KOO21767.1 - 5.3e-13 48.4 2.7 0.00031 20.3 0.0 3.6 3 0 0 3 3 3 3 TPR repeat TPR_2 PF07719.12 KOO21767.1 - 1.2e-12 46.6 7.7 5.8e-05 22.7 0.0 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO21767.1 - 2.3e-11 42.8 5.1 6.1e-05 22.4 0.0 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOO21767.1 - 1.2e-09 37.9 5.0 0.0095 16.4 0.0 4.8 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOO21767.1 - 2.3e-08 34.2 0.7 0.075 13.3 0.0 3.8 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO21767.1 - 1.5e-06 28.0 7.3 0.028 14.3 0.2 4.3 2 1 1 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO21767.1 - 1.6e-06 27.4 0.0 0.099 12.4 0.0 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO21767.1 - 3.9e-05 24.2 10.1 0.071 13.8 0.0 4.1 3 1 2 5 5 4 2 Tetratricopeptide repeat TPR_15 PF13429.1 KOO21767.1 - 0.00013 21.1 0.5 0.054 12.5 0.0 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat Translat_reg PF01818.12 KOO21767.1 - 0.0017 17.8 1.4 0.93 9.0 0.1 2.5 2 0 0 2 2 2 2 Bacteriophage translational regulator TPR_6 PF13174.1 KOO21767.1 - 0.033 14.6 3.1 1.3 9.6 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO21767.1 - 0.83 9.5 6.0 0.76 9.6 0.3 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF2116 PF09889.4 KOO21767.1 - 5.4 6.9 6.7 2.2 8.1 2.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Motile_Sperm PF00635.21 KOO21768.1 - 1.2e-17 63.5 0.0 0.00064 19.3 0.0 8.2 10 0 0 10 10 10 4 MSP (Major sperm protein) domain PapD-like PF14874.1 KOO21768.1 - 8.8e-10 38.4 0.4 0.51 10.3 0.0 5.8 6 0 0 6 6 6 3 Flagellar-associated PapD-like DUF1034 PF06280.7 KOO21768.1 - 1.8e-05 25.0 0.7 6.4 7.2 0.0 6.1 5 1 0 6 6 6 1 Fn3-like domain (DUF1034) Transglut_C PF00927.17 KOO21768.1 - 0.00013 21.9 0.1 0.31 11.1 0.0 4.2 3 0 0 3 3 3 1 Transglutaminase family, C-terminal ig like domain Fn3-like PF14310.1 KOO21768.1 - 0.033 14.1 0.0 1 9.3 0.0 3.1 3 0 0 3 3 3 0 Fibronectin type III-like domain Laminin_G_3 PF13385.1 KOO21769.1 - 1e-05 25.8 0.0 1.4e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily EF-hand_6 PF13405.1 KOO21769.1 - 0.00055 19.6 0.2 0.0021 17.7 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 KOO21769.1 - 0.0026 16.9 0.0 0.035 13.4 0.0 2.4 2 0 0 2 2 2 1 EF hand Pkinase PF00069.20 KOO21770.1 - 3.5e-64 216.4 0.0 6.1e-64 215.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21770.1 - 1.6e-39 135.5 0.0 2.5e-39 134.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase SnoaL PF07366.7 KOO21770.1 - 6.1e-11 42.0 0.2 2.1e-10 40.2 0.0 2.1 2 0 0 2 2 2 1 SnoaL-like polyketide cyclase PAS_9 PF13426.1 KOO21770.1 - 9.7e-09 35.5 0.0 5.8e-05 23.4 0.0 3.7 4 0 0 4 4 4 2 PAS domain Kinase-like PF14531.1 KOO21770.1 - 0.00012 21.2 0.0 0.0025 16.8 0.0 2.3 2 0 0 2 2 2 1 Kinase-like DIE2_ALG10 PF04922.7 KOO21771.1 - 0.026 13.5 0.1 0.039 12.9 0.0 1.3 1 0 0 1 1 1 0 DIE2/ALG10 family JAB PF01398.16 KOO21772.1 - 7.8e-14 51.3 0.0 1.4e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease TRM PF02005.11 KOO21773.1 - 1.3e-11 44.0 0.1 9.1e-11 41.2 0.1 1.9 2 0 0 2 2 2 1 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_26 PF13659.1 KOO21773.1 - 2.4e-05 24.3 0.1 3.3e-05 23.8 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain DUF4653 PF15546.1 KOO21773.1 - 0.38 10.0 1.2 0.47 9.6 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4653) DUF3708 PF12501.3 KOO21775.1 - 0.078 12.8 3.5 0.085 12.6 1.5 1.8 2 0 0 2 2 2 0 Phosphate ATP-binding cassette transporter p25-alpha PF05517.7 KOO21777.1 - 1.4e-06 28.6 21.1 2 8.6 0.0 9.2 10 0 0 10 10 10 4 p25-alpha DnaI_N PF07319.6 KOO21777.1 - 0.7 10.1 6.4 8.5 6.7 0.1 4.1 4 0 0 4 4 4 0 Primosomal protein DnaI N-terminus EF-hand_1 PF00036.27 KOO21778.1 - 5.5e-05 22.1 16.1 0.51 9.7 0.0 10.8 11 0 0 11 11 11 1 EF hand Abhydrolase_5 PF12695.2 KOO21778.1 - 0.0065 16.2 0.0 0.047 13.4 0.0 2.4 2 1 0 2 2 2 1 Alpha/beta hydrolase family UPF0227 PF05728.7 KOO21778.1 - 0.14 11.8 0.0 0.34 10.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) zf-RING_3 PF14369.1 KOO21780.1 - 0.12 12.3 0.7 0.25 11.3 0.5 1.5 1 0 0 1 1 1 0 zinc-finger Siva PF05458.7 KOO21780.1 - 0.18 11.3 2.2 0.32 10.5 1.5 1.3 1 0 0 1 1 1 0 Cd27 binding protein (Siva) U-box PF04564.10 KOO21781.1 - 8.7e-16 57.6 0.0 1.3e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO21781.1 - 6.8e-05 22.3 0.0 0.00012 21.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Peptidase_S30 PF01577.11 KOO21781.1 - 0.19 11.0 4.1 0.29 10.4 2.9 1.2 1 0 0 1 1 1 0 Potyvirus P1 protease DUF4557 PF15101.1 KOO21781.1 - 0.5 10.1 4.6 0.58 9.9 2.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4557) Rtf2 PF04641.7 KOO21781.1 - 0.54 9.4 20.1 4.3 6.4 0.0 2.4 1 1 2 3 3 3 0 Rtf2 RING-finger Herpes_env PF01673.13 KOO21781.1 - 0.57 8.6 3.0 0.68 8.4 2.1 1.1 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein PAT1 PF09770.4 KOO21781.1 - 4.4 5.4 8.9 5.2 5.1 6.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FLO_LFY PF01698.11 KOO21781.1 - 7.1 5.3 11.5 9.2 4.9 7.9 1.1 1 0 0 1 1 1 0 Floricaula / Leafy protein RR_TM4-6 PF06459.7 KOO21781.1 - 9.8 5.9 12.6 17 5.2 8.8 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TIG PF01833.19 KOO21782.1 - 5.2e-43 144.9 4.5 8.2e-09 35.3 0.1 5.2 5 0 0 5 5 5 5 IPT/TIG domain HSP90 PF00183.13 KOO21783.1 - 2.8e-144 481.4 0.1 1.8e-135 452.3 0.0 2.0 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.1 KOO21783.1 - 4.9e-13 48.9 0.2 1.2e-12 47.6 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 KOO21783.1 - 3.8e-10 39.4 0.1 7.8e-10 38.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ank_5 PF13857.1 KOO21784.1 - 2e-05 24.6 0.5 0.00012 22.2 0.2 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) zf-MYND PF01753.13 KOO21784.1 - 5.3e-05 22.9 20.2 0.00016 21.4 14.0 1.9 1 0 0 1 1 1 1 MYND finger Ank_4 PF13637.1 KOO21784.1 - 8.6e-05 22.9 0.0 0.00031 21.1 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO21784.1 - 0.00014 22.0 0.2 0.00031 21.0 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO21784.1 - 0.054 13.3 0.6 0.31 10.9 0.1 2.5 3 0 0 3 3 3 0 Ankyrin repeat Ank_3 PF13606.1 KOO21784.1 - 0.055 13.7 0.8 0.73 10.2 0.0 3.1 4 0 0 4 4 4 0 Ankyrin repeat Peptidase_A24 PF01478.13 KOO21784.1 - 0.14 12.3 0.1 0.32 11.1 0.1 1.5 1 0 0 1 1 1 0 Type IV leader peptidase family IU_nuc_hydro PF01156.14 KOO21785.1 - 5.3e-13 48.8 0.9 2.7e-06 26.8 0.2 2.6 2 1 0 2 2 2 2 Inosine-uridine preferring nucleoside hydrolase Collagen PF01391.13 KOO21785.1 - 0.00065 19.1 5.7 0.0014 18.1 4.0 1.4 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) TraT PF05818.7 KOO21785.1 - 0.053 12.9 0.0 1.6 8.1 0.0 2.4 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein Dynein_light PF01221.13 KOO21786.1 - 2.3e-45 152.5 1.6 2.5e-45 152.3 1.1 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Imm28 PF15574.1 KOO21786.1 - 0.043 13.3 0.1 0.061 12.8 0.1 1.3 1 0 0 1 1 1 0 Immunity protein 28 Ground-like PF04155.13 KOO21786.1 - 0.069 13.4 0.1 0.098 12.9 0.1 1.3 1 1 0 1 1 1 0 Ground-like domain UCH PF00443.24 KOO21786.1 - 0.079 12.0 0.1 0.094 11.8 0.1 1.0 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase HEXIM PF15313.1 KOO21786.1 - 0.099 12.8 0.2 0.12 12.5 0.1 1.1 1 0 0 1 1 1 0 Hexamethylene bis-acetamide-inducible protein SpoIIIAH PF12685.2 KOO21786.1 - 0.26 10.7 2.0 0.31 10.4 1.4 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein SPA PF08616.5 KOO21787.1 - 7.2e-06 25.6 0.0 1.2e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.4 KOO21787.1 - 2e-05 23.2 0.0 3.7e-05 22.3 0.0 1.4 2 0 0 2 2 2 1 Transport protein Avl9 Afi1 PF07792.7 KOO21787.1 - 0.06 13.3 0.0 4.3 7.3 0.0 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking adh_short PF00106.20 KOO21788.1 - 5.8e-15 55.5 7.5 1.1e-14 54.6 3.4 2.7 2 1 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 KOO21788.1 - 3.5e-05 23.5 0.2 0.00011 21.9 0.2 1.8 1 1 0 1 1 1 1 KR domain LRR_4 PF12799.2 KOO21788.1 - 0.001 18.6 0.0 0.24 11.0 0.0 3.3 2 1 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO21788.1 - 0.0017 18.2 0.3 11 6.7 0.0 4.7 4 0 0 4 4 4 1 Leucine rich repeat F-box-like PF12937.2 KOO21788.1 - 0.0025 17.5 0.0 0.0072 16.0 0.0 1.9 1 0 0 1 1 1 1 F-box-like adh_short_C2 PF13561.1 KOO21788.1 - 0.0093 15.7 0.0 0.023 14.4 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase LRR_1 PF00560.28 KOO21788.1 - 0.011 15.6 0.3 57 4.3 0.0 4.1 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.1 KOO21788.1 - 0.027 14.4 0.0 4.4 7.6 0.0 3.8 3 0 0 3 3 3 0 Leucine Rich repeat RE_XamI PF09572.5 KOO21788.1 - 0.1 12.0 0.1 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 XamI restriction endonuclease LRR_8 PF13855.1 KOO21788.1 - 0.11 12.2 0.5 1.5 8.6 0.1 2.6 1 1 1 2 2 2 0 Leucine rich repeat MoeA_N PF03453.12 KOO21788.1 - 0.12 11.7 0.2 0.21 10.9 0.1 1.3 1 0 0 1 1 1 0 MoeA N-terminal region (domain I and II) EF-hand_1 PF00036.27 KOO21790.1 - 4.8e-14 50.4 0.0 2.5e-06 26.3 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO21790.1 - 3.4e-12 46.3 0.0 6e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair Methyltransf_21 PF05050.7 KOO21790.1 - 5.1e-12 46.0 0.0 9.9e-12 45.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase FkbM domain EF-hand_8 PF13833.1 KOO21790.1 - 1.3e-11 43.9 0.8 2.6e-11 42.9 0.2 1.8 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO21790.1 - 1.5e-10 40.0 0.0 8e-05 22.1 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO21790.1 - 2.1e-09 36.2 0.1 0.00033 19.8 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.1 KOO21790.1 - 2.4e-05 24.1 0.0 6.3e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.2 KOO21790.1 - 0.047 13.4 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand TPR_11 PF13414.1 KOO21791.1 - 3.8e-12 45.6 2.7 1.2e-08 34.4 0.3 3.1 2 1 2 4 4 4 3 TPR repeat TPR_17 PF13431.1 KOO21791.1 - 1.4e-08 34.2 2.9 0.05 13.8 0.1 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO21791.1 - 7.6e-07 28.4 2.2 0.012 15.2 0.0 5.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO21791.1 - 5.3e-06 26.6 1.3 0.0021 18.3 0.1 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO21791.1 - 9.8e-06 26.1 8.6 0.01 16.4 1.8 3.6 2 1 2 4 4 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO21791.1 - 1.1e-05 24.9 7.1 0.046 13.6 0.0 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO21791.1 - 3.5e-05 24.0 2.6 0.02 15.4 0.0 4.3 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOO21791.1 - 0.00039 20.2 0.7 0.026 14.4 0.1 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat BTAD PF03704.12 KOO21791.1 - 0.0034 17.6 0.5 0.077 13.2 0.0 2.8 2 1 1 3 3 3 1 Bacterial transcriptional activator domain TPR_6 PF13174.1 KOO21791.1 - 0.075 13.5 0.4 41 4.9 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOO21791.1 - 0.091 12.5 0.1 29 4.7 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat EF-hand_1 PF00036.27 KOO21792.1 - 1.5e-13 49.0 0.0 1.2e-05 24.2 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO21792.1 - 6.5e-12 44.2 0.1 2.5e-06 26.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO21792.1 - 3.8e-11 42.9 0.0 4.1e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO21792.1 - 1e-09 37.3 0.4 4.6e-05 22.5 0.1 2.2 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO21792.1 - 8.8e-09 34.8 0.0 5.5e-06 25.9 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_10 PF14788.1 KOO21792.1 - 0.0075 15.9 0.0 2 8.1 0.0 2.1 2 0 0 2 2 2 2 EF hand GpcrRhopsn4 PF10192.4 KOO21794.1 - 1e-35 123.1 0.1 2.4e-35 121.9 0.1 1.6 1 1 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain Lung_7-TM_R PF06814.8 KOO21794.1 - 0.095 11.6 1.2 0.15 10.9 0.8 1.2 1 0 0 1 1 1 0 Lung seven transmembrane receptor Gryzun PF07919.7 KOO21794.1 - 0.26 9.5 0.1 0.97 7.6 0.0 1.7 2 0 0 2 2 2 0 Gryzun, putative trafficking through Golgi ERM PF00769.14 KOO21796.1 - 0.087 12.3 10.1 0.1 12.0 7.0 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family U1snRNP70_N PF12220.3 KOO21796.1 - 0.13 12.5 2.0 1.6 9.1 0.1 2.1 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal CRAL_TRIO PF00650.15 KOO21797.1 - 3.9e-14 52.4 0.0 5.1e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain PDZ PF00595.19 KOO21798.1 - 0.00029 20.9 0.0 0.00061 19.9 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO21798.1 - 0.036 13.9 0.0 0.062 13.1 0.0 1.4 1 0 0 1 1 1 0 PDZ domain HeH PF12949.2 KOO21800.1 - 0.0022 17.4 0.0 0.0037 16.7 0.0 1.4 1 0 0 1 1 1 1 HeH/LEM domain SAP PF02037.22 KOO21800.1 - 0.0066 15.9 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 SAP domain HSP20 PF00011.16 KOO21802.1 - 1.8e-13 50.2 0.1 3.6e-13 49.2 0.1 1.5 1 0 0 1 1 1 1 Hsp20/alpha crystallin family MMR_HSR1 PF01926.18 KOO21802.1 - 0.00039 20.3 0.1 0.0026 17.7 0.1 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase GBP PF02263.14 KOO21802.1 - 0.0014 17.6 2.1 0.0092 15.0 0.0 2.1 1 1 1 2 2 2 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.18 KOO21802.1 - 0.022 14.6 1.2 1.6 8.5 0.1 2.9 3 0 0 3 3 3 0 Dynamin family HSP20 PF00011.16 KOO21803.1 - 1.1e-13 50.8 0.1 2.3e-13 49.8 0.1 1.5 1 0 0 1 1 1 1 Hsp20/alpha crystallin family GBP PF02263.14 KOO21803.1 - 0.0032 16.5 0.0 0.0054 15.8 0.0 1.4 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.18 KOO21803.1 - 0.012 15.5 0.2 0.084 12.8 0.1 2.1 1 1 0 2 2 2 0 50S ribosome-binding GTPase Methyltransf_21 PF05050.7 KOO21804.1 - 0.0026 17.7 0.0 0.0078 16.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase FkbM domain SET PF00856.23 KOO21804.1 - 0.011 16.0 0.0 0.023 15.0 0.0 1.5 1 0 0 1 1 1 0 SET domain RelA_SpoT PF04607.12 KOO21806.1 - 1.2e-20 73.6 0.0 1.6e-20 73.2 0.0 1.2 1 0 0 1 1 1 1 Region found in RelA / SpoT proteins Orthopox_C10L PF07020.6 KOO21806.1 - 0.11 12.9 0.1 0.2 12.2 0.1 1.4 1 0 0 1 1 1 0 Orthopoxvirus C10L protein CRAL_TRIO_2 PF13716.1 KOO21809.1 - 1.2e-18 67.4 0.0 1.4e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.15 KOO21809.1 - 6.1e-05 22.5 0.0 7.8e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain Nuc_sug_transp PF04142.10 KOO21811.1 - 5.6e-22 78.0 11.0 1.7e-21 76.4 7.7 1.7 1 1 0 1 1 1 1 Nucleotide-sugar transporter EmrE PF13536.1 KOO21811.1 - 0.02 15.0 10.5 0.46 10.6 0.1 2.5 2 0 0 2 2 2 0 Multidrug resistance efflux transporter Chloroa_b-bind PF00504.16 KOO21812.1 - 1.2e-35 123.0 0.0 1.5e-35 122.7 0.0 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Ustilago_mating PF05722.7 KOO21814.1 - 0.29 10.4 3.5 0.31 10.2 2.4 1.0 1 0 0 1 1 1 0 Ustilago B locus mating-type protein C2 PF00168.25 KOO21815.1 - 1.8e-13 50.1 0.1 4e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 C2 domain CPSF_A PF03178.10 KOO21816.1 - 9.7e-87 291.0 0.0 7.7e-86 288.0 0.0 2.1 2 0 0 2 2 2 1 CPSF A subunit region MMS1_N PF10433.4 KOO21816.1 - 1.4e-74 251.1 0.0 2.4e-74 250.3 0.0 1.4 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term EF-hand_1 PF00036.27 KOO21816.1 - 8.8e-11 40.3 1.5 0.0024 17.0 0.2 3.7 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO21816.1 - 9e-09 34.4 1.6 0.0036 17.0 0.0 3.9 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.1 KOO21816.1 - 3.7e-08 33.3 1.9 3.9e-05 23.7 0.1 3.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO21816.1 - 8.7e-06 25.2 1.4 0.00012 21.5 0.3 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO21816.1 - 8.1e-05 21.7 3.8 0.07 12.5 0.1 3.3 3 0 0 3 3 3 2 EF hand FATC PF02260.15 KOO21816.1 - 0.054 12.9 0.1 0.14 11.6 0.0 1.7 1 0 0 1 1 1 0 FATC domain WD40 PF00400.27 KOO21816.1 - 0.078 12.8 0.1 0.35 10.8 0.0 2.2 2 0 0 2 2 2 0 WD domain, G-beta repeat NIF PF03031.13 KOO21817.1 - 2.5e-51 173.4 0.4 3.3e-51 173.1 0.3 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Ank_2 PF12796.2 KOO21817.1 - 4e-28 97.5 2.4 2.4e-15 56.6 0.0 2.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO21817.1 - 2.7e-22 77.4 0.7 2e-08 33.6 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 KOO21817.1 - 5.8e-21 74.4 0.7 9.5e-09 35.5 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO21817.1 - 8.3e-18 64.0 1.8 3.3e-06 27.1 0.1 4.3 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO21817.1 - 1.6e-16 58.7 0.5 3.2e-05 23.7 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat R3H PF01424.17 KOO21818.1 - 8.2e-12 44.6 0.0 1.6e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 R3H domain MAPEG PF01124.13 KOO21818.1 - 1.9e-08 34.0 0.0 4e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 MAPEG family UBA PF00627.26 KOO21818.1 - 0.0016 18.1 0.0 0.19 11.6 0.0 2.7 2 0 0 2 2 2 1 UBA/TS-N domain UBA_4 PF14555.1 KOO21818.1 - 0.064 12.8 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 UBA-like domain DUF4490 PF14892.1 KOO21819.1 - 7.9e-05 22.2 0.1 0.00019 21.0 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4490) LRR_6 PF13516.1 KOO21820.1 - 1.1e-15 55.9 16.3 0.006 16.5 0.0 8.6 8 0 0 8 8 8 5 Leucine Rich repeat Skp1 PF01466.14 KOO21820.1 - 2.7e-05 24.0 0.0 7e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Skp1 family, dimerisation domain LRR_7 PF13504.1 KOO21820.1 - 5.9e-05 22.6 1.2 1.2e+02 3.5 0.0 6.6 6 0 0 6 6 6 0 Leucine rich repeat LRR_1 PF00560.28 KOO21820.1 - 6.8e-05 22.3 5.8 6.4 7.2 0.1 6.5 7 0 0 7 7 7 1 Leucine Rich Repeat LRR_4 PF12799.2 KOO21820.1 - 0.00042 19.8 7.4 1.7 8.3 0.1 5.3 3 3 1 4 4 4 3 Leucine Rich repeats (2 copies) Phage_attach PF05354.6 KOO21820.1 - 0.12 11.9 0.1 0.33 10.5 0.0 1.7 2 0 0 2 2 2 0 Phage Head-Tail Attachment TIG PF01833.19 KOO21822.1 - 1.2e-23 82.8 5.0 1.8e-08 34.2 0.1 4.9 5 0 0 5 5 5 3 IPT/TIG domain Qn_am_d_aIII PF09099.5 KOO21822.1 - 0.056 13.7 0.4 19 5.6 0.0 4.0 4 0 0 4 4 4 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain III EF_TS PF00889.14 KOO21823.1 - 1.9e-39 135.2 2.6 4.3e-28 98.1 0.1 2.3 1 1 1 2 2 2 2 Elongation factor TS UBA PF00627.26 KOO21823.1 - 2.2e-09 36.8 0.3 5.4e-09 35.6 0.2 1.7 1 0 0 1 1 1 1 UBA/TS-N domain Bromo_TP PF07524.8 KOO21823.1 - 0.00072 19.2 0.1 0.1 12.3 0.0 3.2 3 0 0 3 3 3 1 Bromodomain associated ApoLp-III PF07464.6 KOO21823.1 - 0.094 12.7 2.2 0.11 12.4 0.3 1.9 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) TOBE_2 PF08402.5 KOO21823.1 - 0.13 12.2 0.0 0.3 11.1 0.0 1.6 1 0 0 1 1 1 0 TOBE domain Cupin_8 PF13621.1 KOO21824.1 - 1.1e-31 110.1 0.7 3.8e-31 108.4 0.5 1.7 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 KOO21824.1 - 0.0013 18.0 0.0 0.02 14.1 0.0 2.2 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.17 KOO21824.1 - 0.0022 18.2 0.1 0.0045 17.2 0.0 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase Inositol_P PF00459.20 KOO21825.1 - 2.9e-46 157.9 0.2 3.2e-46 157.8 0.1 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family RRP7 PF12923.2 KOO21826.1 - 5.5e-26 91.1 9.7 7.7e-26 90.6 6.7 1.2 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) HrpA_pilin PF09589.5 KOO21826.1 - 0.078 13.3 0.4 0.13 12.6 0.1 1.5 1 1 1 2 2 2 0 HrpA pilus formation protein Vmethyltransf_C PF08456.5 KOO21826.1 - 0.45 9.8 3.5 1.6 8.1 0.3 2.0 1 1 1 2 2 2 0 Viral methyltransferase C-terminal SYF2 PF08231.7 KOO21826.1 - 1.4 9.0 8.0 2.5 8.2 5.5 1.6 1 1 0 1 1 1 0 SYF2 splicing factor TMA7 PF09072.5 KOO21826.1 - 2.1 8.8 10.6 14 6.2 0.0 2.5 2 1 0 2 2 2 0 Translation machinery associated TMA7 Chromo PF00385.19 KOO21827.1 - 1.1e-12 47.4 0.9 7.6e-12 44.7 0.6 2.4 1 1 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow PF01393.14 KOO21827.1 - 7.9e-05 22.4 0.8 0.043 13.6 0.1 2.8 2 1 0 2 2 2 2 Chromo shadow domain ARID PF01388.16 KOO21827.1 - 0.00025 20.8 0.1 0.00047 19.9 0.0 1.4 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Myb_DNA-bind_6 PF13921.1 KOO21827.1 - 0.07 13.2 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain GUN4 PF05419.7 KOO21828.1 - 9.9e-30 103.0 0.0 1.3e-29 102.6 0.0 1.2 1 0 0 1 1 1 1 GUN4-like UPF0172 PF03665.8 KOO21829.1 - 2.1e-43 148.1 0.0 2.8e-43 147.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) Aminotran_1_2 PF00155.16 KOO21830.1 - 0.0028 16.6 0.0 0.33 9.8 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class I and II Methyltrans_RNA PF04452.9 KOO21831.1 - 1.2e-41 142.3 0.0 1.7e-37 128.7 0.0 2.1 1 1 1 2 2 2 2 RNA methyltransferase Glyco_hydro_79n PF03662.9 KOO21831.1 - 0.00046 18.9 0.0 0.0021 16.7 0.0 2.0 2 1 0 2 2 2 1 Glycosyl hydrolase family 79, N-terminal domain Xpo1 PF08389.7 KOO21832.1 - 6.1e-05 22.9 0.0 0.057 13.3 0.0 4.1 3 0 0 3 3 3 2 Exportin 1-like protein Transmemb_17 PF09799.4 KOO21833.1 - 1.6e-12 47.6 11.7 1.8e-12 47.5 7.8 1.3 1 1 0 1 1 1 1 Predicted membrane protein PTR2 PF00854.16 KOO21833.1 - 0.012 14.3 0.4 0.017 13.9 0.3 1.2 1 0 0 1 1 1 0 POT family AWPM-19 PF05512.6 KOO21833.1 - 0.031 14.2 0.1 0.054 13.4 0.1 1.5 1 0 0 1 1 1 0 AWPM-19-like family SBBP PF06739.6 KOO21835.1 - 5.1e-07 29.3 12.9 0.047 13.4 0.5 4.9 5 0 0 5 5 5 3 Beta-propeller repeat DUF2121 PF09894.4 KOO21835.1 - 0.069 12.4 4.0 9 5.5 0.1 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2121) NHL PF01436.16 KOO21835.1 - 0.68 9.9 4.1 27 4.9 0.1 3.2 3 0 0 3 3 3 0 NHL repeat ACP_syn_III PF08545.5 KOO21835.1 - 3.3 7.4 9.1 35 4.1 0.3 3.4 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Fzo_mitofusin PF04799.8 KOO21835.1 - 4.4 6.6 5.2 5.5 6.3 0.1 2.4 3 0 0 3 3 3 0 fzo-like conserved region Pkinase PF00069.20 KOO21837.1 - 1.9e-68 230.4 0.1 4.4e-68 229.2 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21837.1 - 4.5e-35 120.9 2.1 1.1e-34 119.6 0.6 2.1 2 1 1 3 3 3 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO21837.1 - 6.4e-06 25.3 0.5 3.5e-05 22.8 0.3 2.0 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 KOO21837.1 - 0.1 12.3 0.0 0.32 10.7 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pribosyltran PF00156.22 KOO21838.1 - 6e-16 58.2 0.0 7.9e-16 57.9 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.1 KOO21838.1 - 0.064 12.5 0.0 0.091 12.0 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase UPRTase PF14681.1 KOO21838.1 - 0.13 11.4 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase PAP_fibrillin PF04755.7 KOO21840.1 - 2e-09 37.4 0.0 7.5e-05 22.5 0.0 3.0 2 1 0 2 2 2 2 PAP_fibrillin DUF812 PF05667.6 KOO21842.1 - 0.11 11.0 6.5 0.15 10.5 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) EF-hand_7 PF13499.1 KOO21843.1 - 4.4e-13 49.1 0.2 9e-13 48.1 0.2 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO21843.1 - 2.5e-12 45.1 3.8 2.9e-06 26.1 1.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO21843.1 - 1.5e-11 43.1 1.0 7.5e-05 22.2 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO21843.1 - 1.8e-11 43.4 1.6 4.3e-07 29.4 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO21843.1 - 6.1e-07 28.5 2.4 0.01 15.1 0.3 2.5 2 0 0 2 2 2 2 EF hand Toprim_2 PF13155.1 KOO21843.1 - 0.045 14.0 0.1 1.2 9.5 0.0 2.4 1 1 1 2 2 2 0 Toprim-like Kinesin PF00225.18 KOO21844.1 - 2.4e-61 207.2 0.0 3.2e-61 206.8 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain DUF87 PF01935.12 KOO21844.1 - 0.058 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF87 SAM_PNT PF02198.11 KOO21844.1 - 0.072 12.8 0.1 5.8 6.7 0.0 2.5 2 0 0 2 2 2 0 Sterile alpha motif (SAM)/Pointed domain Bac_DnaA PF00308.13 KOO21844.1 - 0.094 12.3 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_22 PF13401.1 KOO21844.1 - 0.1 12.7 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain PIF1 PF05970.9 KOO21844.1 - 0.2 10.5 0.1 0.33 9.8 0.1 1.2 1 0 0 1 1 1 0 PIF1-like helicase PLC-beta_C PF08703.5 KOO21845.1 - 0.0041 16.8 3.8 0.0054 16.4 2.6 1.2 1 0 0 1 1 1 1 PLC-beta C terminal Jnk-SapK_ap_N PF09744.4 KOO21845.1 - 0.022 14.7 1.2 0.031 14.2 0.9 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 PIN_2 PF10130.4 KOO21845.1 - 0.041 13.9 0.7 0.049 13.6 0.5 1.2 1 0 0 1 1 1 0 PIN domain FlxA PF14282.1 KOO21845.1 - 0.041 13.8 4.2 0.074 12.9 2.9 1.5 1 1 0 1 1 1 0 FlxA-like protein DUF164 PF02591.10 KOO21845.1 - 0.043 13.6 0.2 0.1 12.4 0.1 1.6 1 0 0 1 1 1 0 Putative zinc ribbon domain TBPIP PF07106.8 KOO21845.1 - 0.07 12.6 3.2 0.14 11.7 2.2 1.5 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) ATG19_autophagy PF12744.2 KOO21845.1 - 0.071 12.3 0.4 0.089 12.0 0.3 1.2 1 0 0 1 1 1 0 Autophagy protein Atg19, Atg8-binding Syntaxin-6_N PF09177.6 KOO21845.1 - 0.095 13.1 2.3 0.21 12.0 1.3 1.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF16 PF01519.11 KOO21845.1 - 0.1 12.8 1.1 0.13 12.5 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF16 TPR_MLP1_2 PF07926.7 KOO21845.1 - 0.11 12.2 5.1 0.16 11.6 3.5 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein YlqD PF11068.3 KOO21845.1 - 0.11 12.4 3.3 0.16 12.0 2.3 1.3 1 0 0 1 1 1 0 YlqD protein Translin PF01997.11 KOO21845.1 - 0.13 11.8 1.9 0.15 11.5 1.3 1.2 1 0 0 1 1 1 0 Translin family DUF4200 PF13863.1 KOO21845.1 - 0.13 12.2 7.5 0.18 11.7 0.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) LPP20 PF02169.11 KOO21845.1 - 0.15 12.1 1.6 0.33 11.0 1.1 1.7 1 1 0 1 1 1 0 LPP20 lipoprotein DUF4407 PF14362.1 KOO21845.1 - 0.18 10.7 10.2 0.23 10.3 7.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1993 PF09351.5 KOO21845.1 - 0.21 11.4 1.9 0.24 11.2 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1993) SlyX PF04102.7 KOO21845.1 - 0.28 11.6 5.6 4.2 7.8 0.9 2.4 1 1 1 2 2 2 0 SlyX Mnd1 PF03962.10 KOO21845.1 - 0.59 9.7 6.6 0.67 9.5 4.6 1.3 1 0 0 1 1 1 0 Mnd1 family YtxH PF12732.2 KOO21845.1 - 0.9 9.9 4.3 5 7.5 2.9 2.0 1 1 0 1 1 1 0 YtxH-like protein ADIP PF11559.3 KOO21845.1 - 1 9.2 7.0 1.7 8.5 4.8 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF883 PF05957.8 KOO21845.1 - 2.2 8.7 11.2 1.7 9.0 3.1 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DivIC PF04977.10 KOO21845.1 - 2.9 7.4 9.5 6 6.4 0.7 2.4 2 1 1 3 3 2 0 Septum formation initiator Spt5_N PF11942.3 KOO21845.1 - 5.7 7.6 8.1 21 5.8 1.0 2.1 1 1 1 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal TMF_DNA_bd PF12329.3 KOO21845.1 - 9.5 6.1 10.2 7.1 6.5 0.6 2.5 3 0 0 3 3 2 0 TATA element modulatory factor 1 DNA binding EmrE PF13536.1 KOO21846.1 - 0.0015 18.6 7.5 0.0015 18.6 5.2 3.6 2 1 0 3 3 3 1 Multidrug resistance efflux transporter DUF4231 PF14015.1 KOO21846.1 - 0.04 13.9 1.7 0.04 13.9 1.1 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF4231) Sec7_N PF12783.2 KOO21846.1 - 0.041 13.3 0.2 0.093 12.1 0.1 1.5 1 0 0 1 1 1 0 Guanine nucleotide exchange factor in Golgi transport N-terminal RimM PF01782.13 KOO21847.1 - 1.4e-14 53.7 0.1 2.6e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 RimM N-terminal domain Nop14 PF04147.7 KOO21847.1 - 0.44 8.4 5.2 0.52 8.1 3.6 1.1 1 0 0 1 1 1 0 Nop14-like family Daxx PF03344.10 KOO21847.1 - 4.7 5.5 7.8 8.1 4.7 5.4 1.3 1 0 0 1 1 1 0 Daxx Family DUF2457 PF10446.4 KOO21847.1 - 9.5 4.8 12.0 16 4.0 8.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Arc PF03869.9 KOO21848.1 - 0.34 10.5 1.7 0.37 10.4 0.2 1.7 2 0 0 2 2 2 0 Arc-like DNA binding domain Symplekin_C PF12295.3 KOO21849.1 - 1.7e-42 145.4 0.0 4.7e-42 143.9 0.0 1.8 2 0 0 2 2 2 1 Symplekin tight junction protein C terminal DUF3453 PF11935.3 KOO21849.1 - 8.7e-16 58.0 0.0 3.8e-09 36.3 1.3 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF3453) Epimerase PF01370.16 KOO21850.1 - 3e-52 177.3 0.0 4.1e-52 176.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 KOO21850.1 - 1.9e-07 30.2 0.4 1.8e-06 27.0 0.0 2.1 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.12 KOO21850.1 - 8.7e-07 28.1 0.0 1.4e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.14 KOO21850.1 - 0.0001 21.1 0.4 0.0015 17.3 0.3 2.1 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 KOO21850.1 - 0.0013 17.6 0.1 0.0066 15.3 0.0 1.9 1 1 1 2 2 2 1 Male sterility protein EF-hand_1 PF00036.27 KOO21851.1 - 5.4e-19 65.9 5.9 3.1e-05 22.9 0.1 4.4 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.1 KOO21851.1 - 8e-19 67.5 3.0 9.4e-10 38.4 0.2 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO21851.1 - 1.5e-14 52.4 6.2 0.0022 17.7 0.1 4.8 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO21851.1 - 4e-14 51.2 5.5 2.9e-05 23.1 0.1 4.1 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 KOO21851.1 - 3.9e-12 45.6 7.7 1.8e-05 24.2 0.4 3.5 2 1 1 3 3 3 3 EF-hand domain pair Ank_2 PF12796.2 KOO21851.1 - 2.2e-08 34.3 0.0 0.00021 21.5 0.0 3.5 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) EF-hand_4 PF12763.2 KOO21851.1 - 1.5e-05 24.6 3.4 0.01 15.5 0.3 3.7 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand Ion_trans PF00520.26 KOO21851.1 - 5.7e-05 22.4 10.8 0.0001 21.5 7.5 1.4 1 0 0 1 1 1 1 Ion transport protein EF-hand_9 PF14658.1 KOO21851.1 - 8e-05 22.4 0.3 0.00028 20.7 0.1 2.1 2 0 0 2 2 2 1 EF-hand domain Ank_4 PF13637.1 KOO21851.1 - 0.00054 20.4 0.0 14 6.3 0.0 4.3 4 0 0 4 4 3 0 Ankyrin repeats (many copies) SPARC_Ca_bdg PF10591.4 KOO21851.1 - 0.0054 16.7 0.4 3.2 7.8 0.4 3.3 2 2 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region Ank_5 PF13857.1 KOO21851.1 - 0.0098 16.1 0.3 16 5.9 0.0 4.0 3 1 1 4 4 4 0 Ankyrin repeats (many copies) DUF104 PF01954.11 KOO21851.1 - 0.29 11.2 1.6 0.65 10.0 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF104 Ank PF00023.25 KOO21851.1 - 0.31 10.9 2.4 11 6.0 0.0 4.5 5 0 0 5 5 5 0 Ankyrin repeat Metallophos PF00149.23 KOO21852.1 - 3.9e-12 45.9 0.8 4.4e-11 42.5 0.7 2.5 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.1 KOO21852.1 - 8e-10 38.6 0.1 1.9e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Metallophos_2 PF12850.2 KOO21852.1 - 3.8e-08 33.3 0.0 6.2e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PhoD PF09423.5 KOO21852.1 - 0.0004 19.0 0.0 0.00061 18.4 0.0 1.3 1 0 0 1 1 1 1 PhoD-like phosphatase adh_short PF00106.20 KOO21853.1 - 1.4e-28 99.8 5.0 1.4e-28 99.8 3.4 1.5 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 KOO21853.1 - 3.4e-11 43.3 0.2 4.5e-11 42.9 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KOO21853.1 - 1.6e-10 40.9 1.4 2.3e-10 40.4 1.0 1.2 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.3 KOO21853.1 - 0.021 14.6 0.1 0.057 13.2 0.1 1.7 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase THF_DHG_CYH_C PF02882.14 KOO21853.1 - 0.029 13.4 0.4 0.29 10.1 0.0 2.5 2 1 1 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.16 KOO21853.1 - 0.047 13.1 0.1 0.072 12.5 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family UAA PF08449.6 KOO21854.1 - 6.1e-72 242.0 24.2 7.9e-72 241.7 16.8 1.1 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 KOO21854.1 - 2.8e-07 30.2 14.0 2.8e-07 30.2 9.7 2.1 1 1 1 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 KOO21854.1 - 0.00012 22.0 13.0 0.00012 22.0 9.0 3.1 3 1 0 3 3 3 2 EamA-like transporter family Ndr PF03096.9 KOO21854.1 - 0.011 14.2 0.5 0.018 13.5 0.4 1.4 1 0 0 1 1 1 0 Ndr family XPG_N PF00752.12 KOO21855.1 - 6.5e-29 100.1 0.0 1.1e-28 99.3 0.0 1.4 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.13 KOO21855.1 - 5.7e-27 93.6 0.1 1.2e-26 92.6 0.1 1.5 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.15 KOO21855.1 - 0.00061 19.9 0.0 0.0016 18.6 0.0 1.7 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold 5_3_exonuc_N PF02739.11 KOO21855.1 - 0.0028 17.0 0.0 0.005 16.2 0.0 1.4 1 0 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain HHH_2 PF12826.2 KOO21855.1 - 0.096 12.5 0.0 0.31 10.9 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif NAD_binding_10 PF13460.1 KOO21856.1 - 4.9e-21 75.5 0.1 6.5e-21 75.1 0.1 1.2 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 KOO21856.1 - 5.9e-06 25.8 0.0 1.8e-05 24.2 0.0 1.8 3 0 0 3 3 3 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 KOO21856.1 - 5.5e-05 22.5 0.0 0.00043 19.6 0.1 2.1 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.20 KOO21856.1 - 8.6e-05 22.5 0.8 0.00017 21.5 0.6 1.5 1 0 0 1 1 1 1 short chain dehydrogenase 3Beta_HSD PF01073.14 KOO21856.1 - 0.00056 18.6 0.0 0.00075 18.2 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.15 KOO21856.1 - 0.00061 19.7 0.1 0.0031 17.4 0.1 2.1 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus NAD_binding_4 PF07993.7 KOO21856.1 - 0.0014 17.6 0.0 0.028 13.3 0.0 2.2 2 0 0 2 2 2 1 Male sterility protein KR PF08659.5 KOO21856.1 - 0.0089 15.7 0.2 0.017 14.7 0.1 1.5 1 0 0 1 1 1 1 KR domain TrkA_C PF02080.16 KOO21856.1 - 0.016 14.7 0.3 0.042 13.4 0.0 1.7 2 0 0 2 2 2 0 TrkA-C domain TPR_12 PF13424.1 KOO21858.1 - 2.3e-74 245.3 40.1 3.8e-17 61.9 1.2 7.1 3 1 6 9 9 9 7 Tetratricopeptide repeat TPR_10 PF13374.1 KOO21858.1 - 1.7e-64 212.0 50.7 2.2e-11 43.2 0.6 9.8 9 1 1 10 10 10 8 Tetratricopeptide repeat TPR_1 PF00515.23 KOO21858.1 - 9.9e-14 50.2 15.3 0.016 14.8 0.1 7.6 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.12 KOO21858.1 - 7.1e-13 47.4 23.3 0.18 11.7 0.1 8.9 9 0 0 9 9 8 5 Tetratricopeptide repeat 4HBT_2 PF13279.1 KOO21858.1 - 5.2e-11 43.0 0.0 1.2e-10 41.9 0.0 1.5 1 0 0 1 1 1 1 Thioesterase-like superfamily TPR_11 PF13414.1 KOO21858.1 - 5.5e-10 38.7 11.9 0.0072 15.9 0.6 5.6 1 1 5 6 6 6 6 TPR repeat TPR_17 PF13431.1 KOO21858.1 - 2e-09 36.9 8.3 3.6 8.0 0.0 8.3 10 0 0 10 10 8 3 Tetratricopeptide repeat TPR_4 PF07721.9 KOO21858.1 - 5.5e-08 32.4 57.3 0.02 15.2 0.2 11.5 10 0 0 10 10 9 4 Tetratricopeptide repeat Osmo_CC PF08946.5 KOO21858.1 - 6.3e-07 29.3 0.4 15 5.6 0.0 5.9 5 0 0 5 5 5 0 Osmosensory transporter coiled coil TPR_7 PF13176.1 KOO21858.1 - 8.2e-07 28.3 28.6 1.2 9.1 0.2 8.0 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_16 PF13432.1 KOO21858.1 - 2.7e-06 27.8 53.2 0.00064 20.3 1.4 9.2 8 2 3 11 11 10 6 Tetratricopeptide repeat TPR_19 PF14559.1 KOO21858.1 - 9.8e-06 25.8 28.6 0.034 14.4 0.7 6.4 4 1 3 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.1 KOO21858.1 - 7.1e-05 22.3 11.7 3.5 7.6 0.0 7.0 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_3 PF07720.7 KOO21858.1 - 0.00038 20.1 0.0 55 3.7 0.0 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat ApoLp-III PF07464.6 KOO21858.1 - 0.0033 17.4 0.0 16 5.4 0.0 4.6 2 2 3 5 5 5 0 Apolipophorin-III precursor (apoLp-III) TPR_21 PF09976.4 KOO21858.1 - 5.5 6.9 18.7 1.2 9.1 0.6 5.5 3 2 4 7 7 7 0 Tetratricopeptide repeat Asp PF00026.18 KOO21860.1 - 1.8e-82 277.1 0.0 2.1e-82 276.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 KOO21860.1 - 6.2e-06 26.2 0.0 3.5e-05 23.7 0.0 2.0 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 KOO21860.1 - 6.4e-06 25.8 0.0 2.7e-05 23.7 0.0 2.2 2 1 0 2 2 2 1 Xylanase inhibitor C-terminal ABC_membrane_2 PF06472.10 KOO21861.1 - 1.1e-06 28.0 0.1 1.8e-06 27.3 0.1 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 MdcG PF10620.4 KOO21861.1 - 0.074 12.5 0.6 0.093 12.2 0.4 1.2 1 0 0 1 1 1 0 Phosphoribosyl-dephospho-CoA transferase MdcG ABC_membrane_2 PF06472.10 KOO21862.1 - 5.5e-46 156.9 2.2 7.4e-46 156.5 1.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 SbmA_BacA PF05992.7 KOO21862.1 - 6.1e-10 38.7 3.2 3.1e-09 36.4 2.2 1.9 1 1 0 1 1 1 1 SbmA/BacA-like family ABC_tran PF00005.22 KOO21862.1 - 8.9e-08 32.5 0.0 1.7e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.1 KOO21862.1 - 0.00063 19.2 0.0 0.0014 18.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.13 KOO21862.1 - 0.00076 19.0 0.3 0.0015 18.0 0.0 1.5 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_16 PF13191.1 KOO21862.1 - 0.0046 16.9 0.2 0.013 15.5 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain DUF815 PF05673.8 KOO21862.1 - 0.0088 14.9 0.1 0.016 14.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Mg_chelatase PF01078.16 KOO21862.1 - 0.016 14.3 0.1 0.028 13.5 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF258 PF03193.11 KOO21862.1 - 0.021 14.0 0.0 0.035 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_30 PF13604.1 KOO21862.1 - 0.022 14.3 0.0 0.042 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 KOO21862.1 - 0.042 14.3 0.0 0.092 13.2 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein NeA_P2 PF12312.3 KOO21862.1 - 0.05 12.8 0.1 0.094 11.9 0.0 1.5 1 0 0 1 1 1 0 Nepovirus subgroup A polyprotein AAA_22 PF13401.1 KOO21862.1 - 0.054 13.6 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain MCM PF00493.18 KOO21862.1 - 0.063 12.0 0.0 0.099 11.4 0.0 1.2 1 0 0 1 1 1 0 MCM2/3/5 family Rubredoxin PF00301.15 KOO21863.1 - 1.1e-08 34.7 4.2 2.1e-08 33.8 2.9 1.5 1 0 0 1 1 1 1 Rubredoxin Zn_Tnp_IS1595 PF12760.2 KOO21863.1 - 0.017 14.9 2.1 0.017 14.9 1.4 1.7 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Zn-ribbon_8 PF09723.5 KOO21863.1 - 0.022 14.7 2.1 0.024 14.6 0.3 1.9 2 0 0 2 2 2 0 Zinc ribbon domain TF_Zn_Ribbon PF08271.7 KOO21863.1 - 0.059 12.6 0.8 0.56 9.5 0.0 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding HypA PF01155.14 KOO21863.1 - 0.099 12.3 0.6 0.16 11.6 0.4 1.6 1 1 0 1 1 1 0 Hydrogenase expression/synthesis hypA family PhnA_Zn_Ribbon PF08274.7 KOO21863.1 - 0.25 11.1 3.2 17 5.3 0.2 2.8 3 0 0 3 3 3 0 PhnA Zinc-Ribbon A2L_zn_ribbon PF08792.5 KOO21863.1 - 0.73 9.3 2.8 4.4 6.8 0.1 2.7 3 0 0 3 3 3 0 A2L zinc ribbon domain zf-RanBP PF00641.13 KOO21863.1 - 2.2 7.4 8.4 9.9 5.3 0.2 3.1 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others Nudix_N_2 PF14803.1 KOO21863.1 - 2.9 7.6 6.8 13 5.5 0.1 2.7 3 0 0 3 3 3 0 Nudix N-terminal RNA_POL_M_15KD PF02150.11 KOO21863.1 - 3 7.6 4.4 0.67 9.6 0.2 2.0 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit UCR_Fe-S_N PF10399.4 KOO21863.1 - 9.1 5.5 7.5 9.8 5.4 3.4 2.2 2 0 0 2 2 2 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal DUF4207 PF13904.1 KOO21865.1 - 0.57 9.5 29.1 0.87 8.9 20.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) CAF-1_p150 PF11600.3 KOO21865.1 - 6.6 6.0 51.4 25 4.1 35.7 1.8 1 1 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal BPL_LplA_LipB PF03099.14 KOO21866.1 - 6.1e-10 39.1 0.0 9e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family GSIII_N PF12437.3 KOO21867.1 - 1.4e-46 157.9 0.1 1.4e-45 154.6 0.0 2.3 2 0 0 2 2 2 1 Glutamine synthetase type III N terminal Gln-synt_C PF00120.19 KOO21867.1 - 1.3e-26 93.3 0.0 2.7e-26 92.2 0.0 1.5 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain ERp29 PF07749.7 KOO21867.1 - 0.091 13.3 0.0 0.24 12.0 0.0 1.7 1 0 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain TMF_DNA_bd PF12329.3 KOO21867.1 - 0.25 11.1 0.5 3.6 7.4 0.1 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Mg_trans_NIPA PF05653.9 KOO21868.1 - 1e-21 77.2 9.9 1.7e-21 76.4 6.9 1.3 1 0 0 1 1 1 1 Magnesium transporter NIPA EmrE PF13536.1 KOO21868.1 - 0.00032 20.8 7.3 0.00032 20.8 5.0 3.0 2 1 1 3 3 3 1 Multidrug resistance efflux transporter UPF0546 PF10639.4 KOO21868.1 - 0.0074 16.0 4.5 1.1 9.0 0.4 2.4 2 0 0 2 2 2 2 Uncharacterised protein family UPF0546 Cortexin PF11057.3 KOO21868.1 - 0.083 12.4 0.1 0.23 11.0 0.1 1.8 1 0 0 1 1 1 0 Cortexin of kidney Multi_Drug_Res PF00893.14 KOO21868.1 - 7.3 7.1 15.6 0.1 13.1 1.0 2.9 3 1 0 3 3 3 0 Small Multidrug Resistance protein Pkinase PF00069.20 KOO21869.1 - 1.1e-60 205.0 0.0 1.2e-60 204.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21869.1 - 3e-26 92.0 0.0 6.7e-26 90.9 0.0 1.5 1 1 1 2 2 2 1 Protein tyrosine kinase APH PF01636.18 KOO21869.1 - 0.0016 18.1 0.5 0.0055 16.4 0.1 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 KOO21869.1 - 0.016 14.2 0.2 0.027 13.5 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DnaJ PF00226.26 KOO21869.1 - 0.061 13.0 0.4 0.19 11.4 0.3 1.8 2 0 0 2 2 2 0 DnaJ domain DSPc PF00782.15 KOO21871.1 - 7.3e-30 103.2 0.0 9.7e-30 102.8 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KOO21871.1 - 0.00033 20.0 0.1 0.00072 18.9 0.0 1.4 1 1 0 1 1 1 1 Protein-tyrosine phosphatase G-alpha PF00503.15 KOO21872.1 - 1.7e-104 349.5 0.4 2.2e-104 349.2 0.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 KOO21872.1 - 1.1e-14 54.0 3.0 8.9e-12 44.5 0.1 3.1 2 1 1 3 3 3 2 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KOO21872.1 - 0.00012 21.2 2.1 0.013 14.6 0.2 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region AAA_29 PF13555.1 KOO21872.1 - 0.023 14.2 0.0 0.063 12.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ETRAMP PF09716.5 KOO21872.1 - 0.12 12.3 0.2 5 7.1 0.0 2.5 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) MMR_HSR1 PF01926.18 KOO21872.1 - 0.12 12.2 0.0 15 5.6 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase Glyco_transf_64 PF09258.5 KOO21873.1 - 5.2e-06 25.8 0.0 6.9e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain RRM_1 PF00076.17 KOO21874.1 - 1.4e-22 79.0 0.0 1.7e-12 46.7 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO21874.1 - 8.9e-20 70.4 0.0 3e-11 43.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO21874.1 - 4.3e-07 29.6 0.0 0.00011 21.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Arm PF00514.18 KOO21875.1 - 2.9e-08 33.2 1.7 0.05 13.4 0.1 4.3 3 0 0 3 3 3 3 Armadillo/beta-catenin-like repeat UPF0150 PF03681.10 KOO21875.1 - 0.12 12.0 18.3 2.4 7.8 0.0 5.2 5 0 0 5 5 5 0 Uncharacterised protein family (UPF0150) HEAT PF02985.17 KOO21875.1 - 1 9.6 16.0 1.1 9.4 0.1 6.5 6 0 0 6 6 6 0 HEAT repeat Cas_Cas1 PF01867.11 KOO21876.1 - 4.4 6.2 12.7 5.1 6.0 1.8 2.1 2 0 0 2 2 2 0 CRISPR associated protein Cas1 SAP PF02037.22 KOO21877.1 - 0.0017 17.8 1.6 0.0044 16.4 1.1 1.8 1 0 0 1 1 1 1 SAP domain Peptidase_M32 PF02074.10 KOO21877.1 - 0.36 9.3 0.7 2.4 6.6 0.6 1.9 2 0 0 2 2 2 0 Carboxypeptidase Taq (M32) metallopeptidase UAA PF08449.6 KOO21878.1 - 0.0049 15.8 3.7 0.012 14.5 2.6 1.6 1 1 0 1 1 1 1 UAA transporter family Arm PF00514.18 KOO21879.1 - 7.1e-118 380.9 168.3 1.2e-07 31.2 0.3 42.6 41 2 2 43 43 43 31 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 KOO21879.1 - 3.4e-13 49.2 4.6 0.13 11.3 0.0 10.3 9 2 1 10 10 10 4 Armadillo-like Adaptin_N PF01602.15 KOO21879.1 - 0.009 14.3 0.8 64 1.6 0.0 5.8 7 1 0 7 7 7 0 Adaptin N terminal region V-ATPase_H_C PF11698.3 KOO21879.1 - 0.023 14.5 0.0 6.7 6.6 0.0 4.4 3 0 0 3 3 3 0 V-ATPase subunit H DUF383 PF04063.9 KOO21879.1 - 0.2 11.1 0.0 35 3.8 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF383) Proteasom_PSMB PF10508.4 KOO21879.1 - 0.28 9.4 8.7 0.078 11.2 0.1 4.0 4 1 0 4 4 4 0 Proteasome non-ATPase 26S subunit E3_UbLigase_R4 PF13764.1 KOO21879.1 - 0.65 7.8 0.0 2.7 5.7 0.0 2.0 3 0 0 3 3 3 0 E3 ubiquitin-protein ligase UBR4 TPT PF03151.11 KOO21880.1 - 1e-18 67.4 3.6 1.1e-18 67.3 2.5 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.15 KOO21880.1 - 0.0021 18.0 5.2 0.0027 17.7 3.6 1.1 1 0 0 1 1 1 1 EamA-like transporter family UAA PF08449.6 KOO21880.1 - 0.049 12.5 0.6 0.05 12.5 0.4 1.1 1 0 0 1 1 1 0 UAA transporter family GNVR PF13807.1 KOO21880.1 - 0.14 11.9 0.1 0.14 11.9 0.0 1.7 2 0 0 2 2 2 0 G-rich domain on putative tyrosine kinase DUF1726 PF08351.6 KOO21880.1 - 0.5 10.0 2.6 1.8 8.2 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1726) Arm PF00514.18 KOO21881.1 - 1.2e-53 177.1 52.5 9.6e-06 25.2 0.1 16.3 15 1 0 15 15 15 13 Armadillo/beta-catenin-like repeat V-ATPase_H_N PF03224.9 KOO21881.1 - 1.6e-06 27.4 0.0 0.0027 16.8 0.0 3.6 2 1 0 2 2 2 2 V-ATPase subunit H Arm_2 PF04826.8 KOO21881.1 - 3.9e-05 22.8 0.0 0.63 9.1 0.0 4.8 3 2 1 5 5 5 2 Armadillo-like HEAT PF02985.17 KOO21881.1 - 1.1 9.4 0.0 1.1 9.4 0.0 8.8 10 0 0 10 10 10 0 HEAT repeat CDC48_N PF02359.13 KOO21882.1 - 0.035 14.0 0.0 0.39 10.6 0.0 2.0 1 1 1 2 2 2 0 Cell division protein 48 (CDC48), N-terminal domain TOBE_3 PF12857.2 KOO21882.1 - 0.042 13.6 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 TOBE-like domain Response_reg PF00072.19 KOO21883.1 - 0.0037 17.2 0.3 0.015 15.3 0.0 2.2 2 0 0 2 2 2 1 Response regulator receiver domain HATPase_c PF02518.21 KOO21883.1 - 0.12 12.1 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Inhibitor_I36 PF03995.8 KOO21883.1 - 7.1 7.0 8.5 28 5.1 0.1 4.1 3 1 1 4 4 4 0 Peptidase inhibitor family I36 LRR_4 PF12799.2 KOO21884.1 - 1.5e-26 91.4 64.6 8e-07 28.5 2.0 15.2 13 2 2 16 16 16 8 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO21884.1 - 5.8e-19 65.9 81.3 0.0011 18.8 0.1 24.6 25 1 1 26 26 26 5 Leucine Rich repeat LRR_8 PF13855.1 KOO21884.1 - 3e-16 58.9 66.9 6.2e-07 29.0 3.6 12.5 14 1 1 15 15 15 5 Leucine rich repeat LRR_1 PF00560.28 KOO21884.1 - 5.5e-08 31.7 59.4 1.4 9.2 0.1 18.9 21 0 0 21 21 21 4 Leucine Rich Repeat AAA_19 PF13245.1 KOO21884.1 - 6.5e-06 25.8 0.3 0.035 13.8 0.0 3.2 2 0 0 2 2 2 2 Part of AAA domain AAA PF00004.24 KOO21884.1 - 5.2e-05 23.4 0.0 0.0036 17.5 0.0 2.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.17 KOO21884.1 - 0.018 13.9 0.1 0.76 8.5 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain UvrD-helicase PF00580.16 KOO21884.1 - 0.062 12.5 0.0 2.8 7.1 0.0 2.3 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain HC2 PF07382.6 KOO21885.1 - 0.024 14.5 20.2 0.054 13.3 14.0 1.6 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 DENN PF02141.16 KOO21886.1 - 6.2e-05 22.8 0.0 0.0001 22.1 0.0 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.13 KOO21886.1 - 0.027 14.4 0.0 0.042 13.8 0.0 1.3 1 0 0 1 1 1 0 uDENN domain PIGA PF08288.7 KOO21887.1 - 1.5e-28 98.9 0.2 3.4e-28 97.8 0.2 1.6 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_trans_4_4 PF13579.1 KOO21887.1 - 1.6e-23 83.6 7.1 1.6e-23 83.6 4.9 2.3 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain Glycos_transf_1 PF00534.15 KOO21887.1 - 2.5e-23 82.3 0.0 3.7e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 KOO21887.1 - 4.5e-22 78.6 1.6 1.1e-21 77.3 1.1 1.7 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.1 KOO21887.1 - 6.6e-11 42.5 0.2 2.5e-10 40.6 0.0 2.1 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.6 KOO21887.1 - 0.0019 17.7 0.3 0.095 12.1 0.1 2.3 1 1 0 2 2 2 1 Starch synthase catalytic domain Glyco_trans_4_2 PF13477.1 KOO21887.1 - 0.0075 16.1 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase 4-like PTS_2-RNA PF01885.11 KOO21888.1 - 5.5e-51 172.5 0.1 1.1e-50 171.5 0.0 1.5 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Kdo PF06293.9 KOO21888.1 - 0.00062 18.8 0.1 0.002 17.1 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1018 PF06252.7 KOO21888.1 - 0.025 15.0 0.8 0.6 10.6 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1018) Choline_kinase PF01633.15 KOO21888.1 - 0.057 12.9 0.0 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.17 KOO21888.1 - 0.2 10.9 0.0 0.41 9.9 0.0 1.4 1 0 0 1 1 1 0 RIO1 family HEAT_2 PF13646.1 KOO21889.1 - 0.026 14.8 0.6 0.5 10.6 0.1 2.3 1 1 1 2 2 2 0 HEAT repeats MFS_1 PF07690.11 KOO21890.1 - 3.3e-43 147.7 43.9 3.7e-36 124.5 14.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KOO21890.1 - 0.00029 19.3 21.6 0.022 13.1 6.0 2.8 1 1 2 3 3 3 3 MFS/sugar transport protein Uso1_p115_head PF04869.9 KOO21891.1 - 0.0015 17.3 0.0 0.0025 16.6 0.0 1.2 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, head region Filament PF00038.16 KOO21891.1 - 0.0065 15.9 28.5 0.51 9.7 2.2 3.7 2 1 1 3 3 3 3 Intermediate filament protein AAA_13 PF13166.1 KOO21891.1 - 0.0093 14.4 8.3 1.5 7.1 1.0 3.1 2 1 0 3 3 3 3 AAA domain Shugoshin_N PF07558.6 KOO21891.1 - 0.015 14.9 1.8 3.2 7.5 0.1 3.0 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region TBPIP PF07106.8 KOO21891.1 - 0.022 14.2 13.0 0.32 10.5 0.1 3.9 4 0 0 4 4 4 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) CENP-F_leu_zip PF10473.4 KOO21891.1 - 0.87 9.4 32.8 0.018 14.9 3.9 4.4 3 2 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BBP1_C PF15272.1 KOO21891.1 - 1 8.8 7.8 0.96 8.9 0.6 2.9 2 1 1 3 3 3 0 Spindle pole body component BBP1, C-terminal FlaC_arch PF05377.6 KOO21891.1 - 3 7.8 5.1 53 3.8 0.0 3.8 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Reo_sigmaC PF04582.7 KOO21891.1 - 7.6 5.6 15.4 10 5.1 0.4 3.4 2 1 1 3 3 3 0 Reovirus sigma C capsid protein TMEM247 PF15444.1 KOO21891.1 - 8.2 6.1 7.3 1.3 8.8 1.1 2.1 2 0 0 2 2 2 0 Transmembrane protein 247 Hydrolase_3 PF08282.7 KOO21892.1 - 1.6e-07 31.1 0.0 0.005 16.4 0.0 2.6 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase S6PP PF05116.8 KOO21892.1 - 1.7e-06 27.4 0.0 6.1e-06 25.7 0.0 1.9 2 1 0 2 2 2 1 Sucrose-6F-phosphate phosphohydrolase Glycos_transf_1 PF00534.15 KOO21893.1 - 9.7e-24 83.6 0.0 1.2e-23 83.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 KOO21893.1 - 2e-07 31.2 0.1 3e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 KOO21893.1 - 0.014 15.6 0.2 0.035 14.3 0.0 1.7 1 1 0 1 1 1 0 Glycosyl transferases group 1 Ubiquitin_3 PF14836.1 KOO21893.1 - 0.053 13.1 0.0 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain Ank_2 PF12796.2 KOO21894.1 - 9.2e-30 102.8 0.0 6.1e-17 61.7 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO21894.1 - 1.7e-27 93.8 2.0 1.1e-06 28.1 0.0 4.4 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.1 KOO21894.1 - 1.2e-24 85.7 2.2 7.4e-10 38.7 0.0 4.3 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO21894.1 - 1.6e-20 71.1 1.2 6.4e-05 22.8 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 KOO21894.1 - 1.6e-18 66.7 0.4 5.7e-11 42.6 0.0 3.4 3 1 1 4 4 4 3 Ankyrin repeats (many copies) MORN PF02493.15 KOO21895.1 - 1.5e-79 257.2 62.0 2.7e-10 39.3 2.5 14.3 14 0 0 14 14 14 13 MORN repeat Glyco_transf_29 PF00777.13 KOO21896.1 - 1.4e-34 119.4 0.0 2.4e-34 118.6 0.0 1.3 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) GHMP_kinases_N PF00288.21 KOO21897.1 - 9.6e-11 41.5 7.8 9.6e-11 41.5 5.4 3.7 3 1 0 3 3 3 1 GHMP kinases N terminal domain WD40 PF00400.27 KOO21898.1 - 2.9e-39 131.5 22.6 1.4e-09 37.4 0.1 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.3 KOO21898.1 - 0.0056 14.8 2.1 0.28 9.2 1.5 2.7 2 1 0 2 2 2 2 Nucleoporin Nup120/160 PQQ_3 PF13570.1 KOO21898.1 - 0.093 13.0 2.4 29 5.1 0.3 3.8 3 1 0 3 3 3 0 PQQ-like domain Aminotran_1_2 PF00155.16 KOO21900.1 - 3.4e-52 177.5 0.0 3.9e-52 177.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 KOO21900.1 - 0.00067 18.7 0.0 0.00094 18.3 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 KOO21900.1 - 0.0011 18.2 0.0 0.002 17.3 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 KOO21900.1 - 0.0017 16.7 0.0 0.0022 16.3 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_MocR PF12897.2 KOO21900.1 - 0.021 13.3 0.0 0.03 12.8 0.0 1.2 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase Elong-fact-P_C PF09285.6 KOO21901.1 - 0.0028 16.9 0.0 0.0055 16.0 0.0 1.4 1 0 0 1 1 1 1 Elongation factor P, C-terminal NPCBM_assoc PF10633.4 KOO21901.1 - 0.049 13.6 0.7 5.4 7.1 0.1 2.2 2 0 0 2 2 2 0 NPCBM-associated, NEW3 domain of alpha-galactosidase DnaJ PF00226.26 KOO21902.1 - 4.4e-13 48.7 2.2 4.8e-13 48.6 0.0 2.3 2 0 0 2 2 2 1 DnaJ domain DNA_topoisoIV PF00521.15 KOO21903.1 - 3.1e-122 408.5 0.1 7.6e-122 407.2 0.0 1.7 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseB PF00204.20 KOO21903.1 - 2.1e-30 105.1 1.4 3e-30 104.6 0.1 1.9 2 0 0 2 2 2 1 DNA gyrase B Toprim PF01751.17 KOO21903.1 - 1.7e-13 50.3 0.0 5.4e-13 48.7 0.0 1.9 1 0 0 1 1 1 1 Toprim domain HATPase_c PF02518.21 KOO21903.1 - 2.9e-08 33.4 0.0 5.7e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Actin PF00022.14 KOO21904.1 - 3.7e-09 35.5 0.0 3.9e-09 35.4 0.0 1.1 1 0 0 1 1 1 1 Actin Pkinase PF00069.20 KOO21905.1 - 8.7e-41 139.7 0.0 1.3e-40 139.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO21905.1 - 9.2e-13 47.8 0.0 1.4e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase NPL4 PF05021.10 KOO21905.1 - 2.2e-07 30.3 0.0 3.3e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 NPL4 family Choline_kinase PF01633.15 KOO21905.1 - 0.00016 21.3 0.0 0.00025 20.7 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.18 KOO21905.1 - 0.00025 20.8 0.0 0.001 18.8 0.0 2.0 1 0 0 1 1 1 1 Phosphotransferase enzyme family UN_NPL4 PF11543.3 KOO21905.1 - 0.0012 19.0 0.0 0.0023 18.1 0.0 1.4 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 Actin PF00022.14 KOO21905.1 - 0.0014 17.1 0.1 0.24 9.7 0.0 2.2 2 0 0 2 2 2 2 Actin Kdo PF06293.9 KOO21905.1 - 0.014 14.5 0.0 0.027 13.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Myosin_head PF00063.16 KOO21906.1 - 5e-194 646.2 0.0 8.8e-194 645.4 0.0 1.4 1 0 0 1 1 1 1 Myosin head (motor domain) PH PF00169.24 KOO21906.1 - 1.3e-61 205.3 6.9 4.2e-13 49.3 0.0 8.0 8 0 0 8 8 8 6 PH domain PH_11 PF15413.1 KOO21906.1 - 6.6e-22 77.8 18.4 3.4e-07 30.4 0.3 7.6 7 2 0 7 7 6 5 Pleckstrin homology domain PH_8 PF15409.1 KOO21906.1 - 6.4e-21 74.2 16.1 0.00012 22.0 0.1 7.4 7 0 0 7 7 6 5 Pleckstrin homology domain PDZ PF00595.19 KOO21906.1 - 1.1e-06 28.7 0.0 2.2e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PH_6 PF15406.1 KOO21906.1 - 2.3e-05 24.3 0.1 0.26 11.3 0.0 4.5 4 0 0 4 4 4 1 Pleckstrin homology domain Mcp5_PH PF12814.2 KOO21906.1 - 3e-05 23.9 2.5 0.79 9.6 0.1 4.8 6 0 0 6 6 5 2 Meiotic cell cortex C-terminal pleckstrin homology PDZ_2 PF13180.1 KOO21906.1 - 0.00034 20.4 0.1 0.00074 19.3 0.1 1.5 1 0 0 1 1 1 1 PDZ domain AAA_19 PF13245.1 KOO21906.1 - 0.011 15.4 0.5 0.34 10.6 0.0 2.5 2 0 0 2 2 2 0 Part of AAA domain AAA_22 PF13401.1 KOO21906.1 - 0.016 15.3 0.0 0.12 12.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 KOO21906.1 - 0.08 12.0 0.0 0.2 10.7 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin Vps36_ESCRT-II PF11605.3 KOO21906.1 - 0.16 11.8 0.0 13 5.6 0.0 3.1 3 0 0 3 3 3 0 Vacuolar protein sorting protein 36 Vps36 SopD PF11047.3 KOO21908.1 - 0.056 12.4 0.0 0.077 11.9 0.0 1.1 1 0 0 1 1 1 0 Salmonella outer protein D COesterase PF00135.23 KOO21909.1 - 3.9e-70 237.0 0.0 4.1e-70 236.9 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 KOO21909.1 - 2.4e-06 27.2 1.1 0.00015 21.4 0.0 3.1 3 0 0 3 3 3 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 KOO21909.1 - 0.026 13.7 0.0 0.061 12.5 0.0 1.6 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 KOO21909.1 - 0.026 14.2 0.1 0.059 13.1 0.1 1.9 1 1 0 1 1 1 0 Alpha/beta hydrolase family HC2 PF07382.6 KOO21910.1 - 0.0095 15.8 15.8 0.0095 15.8 10.9 2.7 2 0 0 2 2 2 1 Histone H1-like nucleoprotein HC2 Glyco_transf_34 PF05637.7 KOO21910.1 - 0.034 13.6 0.1 0.071 12.6 0.0 1.4 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family DUF2196 PF09962.4 KOO21910.1 - 0.17 11.7 0.1 0.56 10.0 0.1 1.9 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2196) Ycf54 PF10674.4 KOO21911.1 - 0.018 15.1 1.6 0.11 12.6 1.1 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2488) PP2C_2 PF13672.1 KOO21912.1 - 0.25 10.7 1.5 0.3 10.4 1.0 1.1 1 0 0 1 1 1 0 Protein phosphatase 2C GMC_oxred_C PF05199.8 KOO21913.1 - 1.3e-32 113.0 0.0 1.8e-32 112.6 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase WD40 PF00400.27 KOO21915.1 - 8.6e-16 57.1 1.5 0.001 18.8 0.0 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat LRR_6 PF13516.1 KOO21916.1 - 7.1e-18 62.6 8.9 0.0009 19.0 0.2 6.3 6 0 0 6 6 6 4 Leucine Rich repeat LRR_4 PF12799.2 KOO21916.1 - 1.7e-06 27.5 5.4 0.0022 17.5 0.2 4.0 2 1 3 5 5 5 2 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO21916.1 - 0.0047 16.8 9.0 34 5.2 0.0 6.3 7 0 0 7 7 7 0 Leucine rich repeat LRR_1 PF00560.28 KOO21916.1 - 0.025 14.5 1.7 71 4.0 0.1 5.0 4 2 0 4 4 4 0 Leucine Rich Repeat LRR_2 PF07723.8 KOO21916.1 - 0.14 12.6 1.0 1.6e+02 3.0 0.0 4.1 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_8 PF13855.1 KOO21916.1 - 0.32 10.7 8.1 0.24 11.1 1.0 3.3 1 1 3 4 4 4 0 Leucine rich repeat WD40 PF00400.27 KOO21917.1 - 6.6e-49 162.1 17.3 1.9e-12 46.5 0.2 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat DUF3431 PF11913.3 KOO21917.1 - 4.5e-15 55.7 0.1 4.6e-07 29.5 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3431) PD40 PF07676.7 KOO21917.1 - 1.9e-07 30.6 0.1 0.53 10.0 0.0 3.6 3 0 0 3 3 3 3 WD40-like Beta Propeller Repeat Nbas_N PF15492.1 KOO21917.1 - 0.00036 19.7 0.5 1 8.3 0.0 2.9 1 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal DUF1513 PF07433.6 KOO21917.1 - 0.018 13.9 0.1 1 8.1 0.0 2.8 1 1 3 4 4 4 0 Protein of unknown function (DUF1513) Nup160 PF11715.3 KOO21917.1 - 0.036 12.2 1.7 0.22 9.6 0.1 2.2 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Kelch_4 PF13418.1 KOO21918.1 - 4.2e-07 29.6 22.8 0.0046 16.6 0.4 6.4 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.1 KOO21918.1 - 6.8e-05 22.8 2.8 0.74 10.0 0.0 5.4 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.1 KOO21918.1 - 0.00099 19.2 26.8 0.24 11.6 0.1 6.2 5 1 0 5 5 5 4 Galactose oxidase, central domain V_ATPase_I PF01496.14 KOO21920.1 - 4e-205 683.0 0.0 8.5e-144 480.2 0.0 2.0 2 0 0 2 2 2 2 V-type ATPase 116kDa subunit family DUF763 PF05559.6 KOO21920.1 - 0.012 14.5 0.2 0.019 13.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF763) PhyH PF05721.8 KOO21921.1 - 2e-12 47.6 0.1 2.9e-11 43.8 0.1 2.1 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_3 PF13640.1 KOO21921.1 - 0.06 13.8 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DUF1479 PF07350.7 KOO21921.1 - 0.1 11.0 0.1 3.5 6.0 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1479) PP2C PF00481.16 KOO21923.1 - 1.1e-71 241.2 0.1 2e-58 197.7 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.1 KOO21923.1 - 1e-06 28.3 0.2 3.4e-05 23.3 0.0 2.2 2 0 0 2 2 2 1 Protein phosphatase 2C DUF1631 PF07793.6 KOO21923.1 - 0.28 9.2 1.3 0.4 8.7 0.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1631) MMR_HSR1 PF01926.18 KOO21924.1 - 1.9e-15 56.8 0.0 3.1e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KOO21924.1 - 0.0036 16.5 0.0 0.0077 15.5 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B DUF258 PF03193.11 KOO21924.1 - 0.0059 15.8 0.1 0.011 14.9 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function, DUF258 Miro PF08477.8 KOO21924.1 - 0.012 16.0 0.0 0.019 15.4 0.0 1.3 1 0 0 1 1 1 0 Miro-like protein AIG1 PF04548.11 KOO21924.1 - 0.013 14.6 0.0 0.021 13.9 0.0 1.3 1 0 0 1 1 1 0 AIG1 family Dynamin_N PF00350.18 KOO21924.1 - 0.013 15.3 0.0 0.05 13.4 0.0 1.8 2 0 0 2 2 2 0 Dynamin family MFS_1 PF07690.11 KOO21925.1 - 0.0012 17.6 10.0 0.0023 16.7 7.0 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily EcsB PF05975.7 KOO21925.1 - 0.18 10.2 3.0 0.21 9.9 2.1 1.0 1 0 0 1 1 1 0 Bacterial ABC transporter protein EcsB DnaJ PF00226.26 KOO21926.1 - 1.8e-11 43.6 1.0 1.2e-10 40.9 0.1 2.6 2 0 0 2 2 2 1 DnaJ domain Cupin_2 PF07883.6 KOO21927.1 - 3.5e-05 23.2 0.0 4.4e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.7 KOO21927.1 - 0.00085 18.6 0.0 0.0011 18.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF861) ARD PF03079.9 KOO21927.1 - 0.018 15.0 0.0 0.025 14.5 0.0 1.3 1 0 0 1 1 1 0 ARD/ARD' family Cupin_1 PF00190.17 KOO21927.1 - 0.032 13.6 0.0 0.041 13.3 0.0 1.1 1 0 0 1 1 1 0 Cupin Cupin_6 PF12852.2 KOO21927.1 - 0.12 11.9 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 Cupin Aminotran_4 PF01063.14 KOO21931.1 - 6e-23 81.5 0.0 7.8e-23 81.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class IV Bestrophin PF01062.16 KOO21932.1 - 1.2e-22 80.2 0.0 1.8e-22 79.6 0.0 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel PGK PF00162.14 KOO21935.1 - 1.3e-140 468.3 0.4 1.7e-140 467.9 0.3 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase VKOR PF07884.9 KOO21936.1 - 5.1e-19 68.4 8.4 6.7e-19 68.1 5.9 1.1 1 0 0 1 1 1 1 Vitamin K epoxide reductase family Chorismate_bind PF00425.13 KOO21937.1 - 4.6e-63 212.9 0.0 6.3e-63 212.4 0.0 1.1 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.23 KOO21937.1 - 1.2e-09 37.9 0.0 2.2e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.8 KOO21937.1 - 5.3e-09 36.2 0.0 7.1e-07 29.3 0.0 2.7 3 0 0 3 3 3 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.8 KOO21937.1 - 0.029 13.8 0.0 0.05 13.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase C26 XAP5 PF04921.9 KOO21938.1 - 5.9e-09 35.8 7.9 0.00034 20.2 1.5 2.6 2 1 0 2 2 2 2 XAP5, circadian clock regulator DUF3338 PF11819.3 KOO21939.1 - 0.09 12.2 2.7 0.2 11.0 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3338) Metallophos PF00149.23 KOO21940.1 - 1.8e-11 43.8 1.0 4.3e-11 42.5 0.2 1.9 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Glyco_transf_8 PF01501.15 KOO21941.1 - 0.011 15.1 0.1 0.57 9.4 0.0 2.5 2 1 0 2 2 2 0 Glycosyl transferase family 8 TMF_DNA_bd PF12329.3 KOO21942.1 - 0.0052 16.5 9.6 0.0052 16.5 6.7 6.4 6 2 1 7 7 7 1 TATA element modulatory factor 1 DNA binding Orbi_VP2 PF00898.12 KOO21942.1 - 0.19 9.2 13.3 0.19 9.2 8.6 1.3 1 1 0 1 1 1 0 Orbivirus outer capsid protein VP2 Reo_sigmaC PF04582.7 KOO21942.1 - 0.34 10.0 2.7 3.3 6.8 0.2 2.4 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Adeno_PIX PF03955.9 KOO21942.1 - 4.4 7.8 20.7 0.08 13.4 0.7 4.3 1 1 4 5 5 5 0 Adenovirus hexon-associated protein (IX) Metallophos PF00149.23 KOO21943.1 - 4.3e-06 26.2 0.1 0.00037 19.9 0.1 2.3 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase Methyltransf_4 PF02390.12 KOO21944.1 - 3.9e-07 29.3 0.0 2.6e-06 26.6 0.0 1.9 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_26 PF13659.1 KOO21944.1 - 6.5e-06 26.1 1.1 1.1e-05 25.4 0.8 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO21944.1 - 2.4e-05 23.9 0.0 4.3e-05 23.1 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO21944.1 - 6.7e-05 23.4 0.0 0.0001 22.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.8 KOO21944.1 - 0.00018 20.9 0.0 0.00041 19.7 0.0 1.7 1 1 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_2 PF00891.13 KOO21944.1 - 0.00068 18.8 0.2 0.0015 17.8 0.1 1.5 2 0 0 2 2 2 1 O-methyltransferase Methyltransf_11 PF08241.7 KOO21944.1 - 0.0021 18.4 0.1 0.0044 17.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 KOO21944.1 - 0.0088 15.4 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.15 KOO21944.1 - 0.079 12.0 0.0 0.14 11.1 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase GidB PF02527.10 KOO21944.1 - 0.15 11.1 0.0 0.25 10.4 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G PCMT PF01135.14 KOO21944.1 - 0.15 11.5 0.0 0.34 10.4 0.0 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Peptidase_C1 PF00112.18 KOO21945.1 - 5.4e-42 144.1 14.5 9.1e-42 143.3 10.0 1.4 1 1 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.10 KOO21945.1 - 0.00082 18.0 0.7 0.0012 17.4 0.5 1.2 1 0 0 1 1 1 1 Peptidase C1-like family Methyltransf_21 PF05050.7 KOO21947.1 - 3.4e-14 53.1 0.0 7.1e-14 52.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase FkbM domain Neur_chan_memb PF02932.11 KOO21947.1 - 0.00066 19.6 0.1 0.0012 18.7 0.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.18 KOO21947.1 - 0.0071 15.5 0.0 0.63 9.1 0.0 2.3 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel ligand binding domain Hydrolase_like PF13242.1 KOO21949.1 - 0.00019 21.0 0.0 0.00028 20.5 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.1 KOO21949.1 - 0.0038 17.4 2.5 0.5 10.5 0.0 2.1 1 1 1 2 2 2 2 Haloacid dehalogenase-like hydrolase MtrC PF04211.8 KOO21951.1 - 0.0042 16.1 0.4 0.005 15.9 0.3 1.0 1 0 0 1 1 1 1 Tetrahydromethanopterin S-methyltransferase, subunit C Gly-zipper_YMGG PF13441.1 KOO21951.1 - 5.3 6.6 12.1 2.4 7.7 3.6 2.3 1 1 1 2 2 2 0 YMGG-like Gly-zipper Gly-zipper_OmpA PF13436.1 KOO21951.1 - 8.2 6.1 6.4 2 8.1 0.2 2.3 2 1 1 3 3 3 0 Glycine-zipper containing OmpA-like membrane domain Glyco_transf_34 PF05637.7 KOO21952.1 - 0.06 12.8 1.4 0.06 12.8 0.2 1.5 2 0 0 2 2 2 0 galactosyl transferase GMA12/MNN10 family Glyco_hydro_2_C PF02836.12 KOO21953.1 - 1.6e-05 23.9 0.0 3e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.13 KOO21953.1 - 0.0035 16.9 0.0 0.0072 15.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.16 KOO21953.1 - 0.0038 17.6 0.0 0.0081 16.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 CH PF00307.26 KOO21954.1 - 5e-21 74.7 0.0 1.1e-10 41.4 0.0 2.5 2 0 0 2 2 2 2 Calponin homology (CH) domain EF-hand_1 PF00036.27 KOO21954.1 - 0.00024 20.2 0.1 0.13 11.5 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO21954.1 - 0.00062 19.8 0.0 0.0046 17.0 0.0 2.3 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO21954.1 - 0.0038 16.8 0.0 0.042 13.4 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_10 PF14788.1 KOO21954.1 - 0.01 15.4 0.4 3 7.5 0.0 2.6 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.1 KOO21954.1 - 0.019 14.7 0.0 11 6.2 0.0 3.1 3 0 0 3 3 3 0 EF-hand domain PhyH PF05721.8 KOO21955.1 - 7.8e-13 48.9 0.8 7.6e-12 45.7 0.6 1.9 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Methyltransf_12 PF08242.7 KOO21956.1 - 6.7e-08 32.9 0.0 1.7e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO21956.1 - 1e-07 32.3 0.6 2.3e-07 31.1 0.1 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO21956.1 - 2.2e-07 30.6 0.0 3.6e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO21956.1 - 2.2e-06 28.2 1.5 3.6e-06 27.5 0.1 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO21956.1 - 4.1e-06 26.5 0.0 7.2e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO21956.1 - 2.5e-05 24.3 5.3 5.6e-05 23.1 0.3 2.5 2 0 0 2 2 2 1 Methyltransferase domain DUF3259 PF11652.3 KOO21956.1 - 0.0078 16.3 0.1 0.019 15.0 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3259) Methyltransf_25 PF13649.1 KOO21956.1 - 0.01 16.1 2.6 0.036 14.4 0.1 2.3 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.9 KOO21956.1 - 0.021 14.2 0.3 0.092 12.1 0.2 2.1 1 1 0 1 1 1 0 Methyltransferase small domain FlxA PF14282.1 KOO21956.1 - 0.052 13.4 0.2 0.088 12.7 0.2 1.3 1 0 0 1 1 1 0 FlxA-like protein Ubie_methyltran PF01209.13 KOO21956.1 - 0.11 11.5 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.4 KOO21956.1 - 0.17 11.3 0.0 0.39 10.1 0.0 1.5 1 1 0 1 1 1 0 Putative methyltransferase DUF2293 PF10056.4 KOO21956.1 - 0.95 9.4 6.5 0.82 9.6 3.3 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2293) DUF1162 PF06650.7 KOO21958.1 - 9.2e-22 77.5 0.0 8.9e-19 67.7 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1162) DUF3458 PF11940.3 KOO21959.1 - 3.8e-124 414.2 0.7 5.8e-124 413.6 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Peptidase_M1 PF01433.15 KOO21959.1 - 4.3e-63 213.7 0.0 6.8e-63 213.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M1 Peptidase_MA_2 PF13485.1 KOO21959.1 - 5e-17 62.1 0.3 3.3e-16 59.5 0.0 2.4 3 0 0 3 3 3 1 Peptidase MA superfamily CBM_X2 PF03442.9 KOO21959.1 - 0.13 12.0 0.0 0.38 10.6 0.0 1.7 1 0 0 1 1 1 0 Carbohydrate binding domain X2 Ion_trans_2 PF07885.11 KOO21960.1 - 1e-10 41.1 0.9 1e-10 41.1 0.6 2.3 2 0 0 2 2 2 1 Ion channel Ion_trans PF00520.26 KOO21960.1 - 0.00028 20.1 9.8 0.033 13.4 6.6 2.4 1 1 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.24 KOO21960.1 - 0.033 13.9 0.0 0.24 11.2 0.0 2.4 1 1 0 1 1 1 0 Cyclic nucleotide-binding domain PRCC PF10253.4 KOO21960.1 - 0.18 12.5 1.0 0.37 11.4 0.7 1.5 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting ChAPs PF09295.5 KOO21960.1 - 0.26 10.0 0.0 0.41 9.3 0.0 1.2 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) Ion_trans_N PF08412.5 KOO21960.1 - 0.53 9.6 2.3 0.48 9.7 0.0 2.1 2 0 0 2 2 2 0 Ion transport protein N-terminal DUF2360 PF10152.4 KOO21960.1 - 8.5 6.6 8.3 18 5.5 2.2 2.8 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) LRR_5 PF13306.1 KOO21961.1 - 1.5e-168 551.7 0.0 5.2e-38 129.6 0.0 5.5 1 1 4 5 5 5 5 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO21961.1 - 2.3e-48 161.7 0.0 4.9e-05 22.9 0.0 11.7 2 1 13 15 15 15 14 Leucine rich repeat LRR_5 PF13306.1 KOO21962.1 - 2.3e-101 334.5 0.0 1.2e-36 125.2 0.1 3.1 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO21962.1 - 7.9e-35 118.4 1.9 1e-06 28.3 0.0 6.6 2 1 7 9 9 9 8 Leucine rich repeat WW PF00397.21 KOO21962.1 - 1.1e-10 41.1 0.2 1.8e-10 40.4 0.1 1.4 1 0 0 1 1 1 1 WW domain AAA PF00004.24 KOO21963.1 - 3.2e-31 108.2 0.0 4.1e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO21963.1 - 3.4e-07 30.4 0.3 1.9e-06 27.9 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.1 KOO21963.1 - 7.4e-06 25.4 0.6 0.0065 15.8 0.4 2.1 1 1 1 2 2 2 2 AAA domain AAA_2 PF07724.9 KOO21963.1 - 4.2e-05 23.5 0.0 9.1e-05 22.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.12 KOO21963.1 - 6.2e-05 22.4 0.0 8.9e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.1 KOO21963.1 - 9.4e-05 22.5 0.0 0.001 19.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 KOO21963.1 - 0.00016 21.4 0.1 0.00054 19.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 KOO21963.1 - 0.00038 21.2 0.0 0.00051 20.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.8 KOO21963.1 - 0.00098 17.9 0.0 0.0012 17.6 0.0 1.1 1 0 0 1 1 1 1 TIP49 C-terminus RuvB_N PF05496.7 KOO21963.1 - 0.0012 17.9 0.0 0.0016 17.5 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus PhoH PF02562.11 KOO21963.1 - 0.0023 17.2 0.0 0.0046 16.2 0.0 1.5 2 0 0 2 2 2 1 PhoH-like protein RNA_helicase PF00910.17 KOO21963.1 - 0.0029 17.7 0.0 0.004 17.3 0.0 1.4 1 1 0 1 1 1 1 RNA helicase NACHT PF05729.7 KOO21963.1 - 0.0029 17.2 0.1 0.02 14.5 0.0 2.0 2 0 0 2 2 2 1 NACHT domain AAA_33 PF13671.1 KOO21963.1 - 0.0031 17.4 0.0 0.0045 16.8 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOO21963.1 - 0.0032 17.2 0.5 0.0095 15.6 0.4 1.9 1 1 0 1 1 1 1 Part of AAA domain AAA_14 PF13173.1 KOO21963.1 - 0.005 16.7 0.0 0.0064 16.3 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 KOO21963.1 - 0.0071 16.3 0.0 0.0093 15.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.21 KOO21963.1 - 0.015 14.8 0.0 0.035 13.5 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain Mg_chelatase PF01078.16 KOO21963.1 - 0.016 14.3 0.0 0.022 13.9 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.22 KOO21963.1 - 0.017 15.3 0.0 0.023 15.0 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.1 KOO21963.1 - 0.027 14.0 0.1 0.036 13.6 0.1 1.1 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.1 KOO21963.1 - 0.029 14.4 0.0 0.041 13.9 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain Arch_ATPase PF01637.13 KOO21963.1 - 0.031 13.9 0.0 0.19 11.4 0.0 1.8 1 1 1 2 2 2 0 Archaeal ATPase AAA_18 PF13238.1 KOO21963.1 - 0.12 12.7 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 KOO21963.1 - 0.12 11.9 0.1 0.28 10.7 0.0 1.6 1 1 1 2 2 2 0 P-loop containing region of AAA domain SBBP PF06739.6 KOO21965.1 - 1.7e-25 88.5 83.9 3e-05 23.7 1.1 12.4 13 0 0 13 13 13 9 Beta-propeller repeat DUF3712 PF12505.3 KOO21965.1 - 0.011 15.7 1.8 43 4.1 0.0 4.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3712) zf-RanBP PF00641.13 KOO21965.1 - 0.59 9.2 1.8 16 4.6 0.2 2.4 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Ctr PF04145.10 KOO21966.1 - 1.8e-12 47.4 7.2 1.8e-10 41.0 3.7 2.2 1 1 1 2 2 2 2 Ctr copper transporter family HMA PF00403.21 KOO21966.1 - 2.1e-10 40.5 0.6 3e-10 40.0 0.4 1.2 1 0 0 1 1 1 1 Heavy-metal-associated domain TRAM_LAG1_CLN8 PF03798.11 KOO21967.1 - 8.4e-12 45.0 14.1 1e-11 44.8 9.8 1.1 1 0 0 1 1 1 1 TLC domain FAM216B PF15107.1 KOO21969.1 - 0.12 12.2 0.3 11 5.8 0.0 2.3 2 0 0 2 2 2 0 FAM216B protein family Glyco_trans_1_2 PF13524.1 KOO21969.1 - 0.12 12.6 1.1 0.27 11.5 0.0 2.1 3 0 0 3 3 3 0 Glycosyl transferases group 1 LRR_6 PF13516.1 KOO21970.1 - 9.5e-11 40.6 3.2 0.2 11.8 0.0 5.3 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.2 KOO21970.1 - 0.0012 18.4 0.3 2.2 7.9 0.0 3.8 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO21970.1 - 0.013 15.4 4.2 4.6 7.6 0.2 4.7 4 1 0 4 4 4 0 Leucine Rich Repeat LRR_7 PF13504.1 KOO21970.1 - 1.3 9.5 0.1 1.3 9.5 0.1 4.4 5 0 0 5 5 5 0 Leucine rich repeat Methyltransf_21 PF05050.7 KOO21971.1 - 2.3e-15 56.9 0.0 2.8e-15 56.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase FkbM domain PCI PF01399.22 KOO21972.1 - 2.2e-14 53.6 0.3 5.4e-14 52.3 0.1 1.8 2 0 0 2 2 2 1 PCI domain ERp29 PF07749.7 KOO21972.1 - 1.4 9.6 5.4 1.3 9.6 0.3 2.5 2 0 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain WD40 PF00400.27 KOO21973.1 - 1.1e-21 75.8 7.4 2.2e-07 30.5 0.1 5.4 6 0 0 6 6 6 4 WD domain, G-beta repeat DUF962 PF06127.6 KOO21973.1 - 0.00061 19.6 0.3 0.0011 18.8 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF962) HpaP PF09483.5 KOO21974.1 - 0.19 11.6 4.0 0.2 11.5 2.8 1.0 1 0 0 1 1 1 0 Type III secretion protein (HpaP) MFS_1 PF07690.11 KOO21975.1 - 1.5e-17 63.3 19.9 1.5e-17 63.3 13.8 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily LRV PF01816.12 KOO21975.1 - 2.1 8.6 6.3 1.5 9.1 1.7 2.9 2 0 0 2 2 2 0 Leucine rich repeat variant Ion_trans PF00520.26 KOO21976.1 - 7.5e-160 528.0 69.5 1.4e-45 155.0 4.4 4.7 4 1 0 4 4 4 4 Ion transport protein Thioredoxin PF00085.15 KOO21976.1 - 5.5e-23 80.6 0.0 1e-22 79.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin TPR_20 PF14561.1 KOO21976.1 - 5.4e-19 68.0 1.7 1.2e-18 67.0 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat PKD_channel PF08016.7 KOO21976.1 - 7e-09 34.6 65.1 0.00013 20.4 3.2 8.1 6 2 2 8 8 8 5 Polycystin cation channel Thioredoxin_2 PF13098.1 KOO21976.1 - 2e-07 31.1 0.0 7.9e-07 29.2 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 KOO21976.1 - 7.9e-06 25.9 0.0 7e-05 22.8 0.0 2.3 1 1 1 2 2 2 1 Thioredoxin-like AhpC-TSA PF00578.16 KOO21976.1 - 8.3e-05 22.2 0.0 0.00018 21.2 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 KOO21976.1 - 0.0017 17.9 0.0 0.005 16.4 0.0 1.8 1 0 0 1 1 1 1 Redoxin TPR_16 PF13432.1 KOO21976.1 - 0.0093 16.6 5.7 0.0093 16.6 3.9 3.5 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOO21976.1 - 0.015 14.9 1.9 0.42 10.2 0.3 2.6 2 0 0 2 2 2 0 TPR repeat Thioredoxin_7 PF13899.1 KOO21976.1 - 0.022 14.7 0.0 0.051 13.5 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like tRNA_int_end_N2 PF12928.2 KOO21977.1 - 2.1e-07 30.3 0.0 4e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term Ion_trans PF00520.26 KOO21978.1 - 0.0044 16.3 1.1 0.0044 16.3 0.7 2.3 2 0 0 2 2 2 2 Ion transport protein CALCOCO1 PF07888.6 KOO21979.1 - 0.0011 17.3 2.9 0.0011 17.3 2.0 5.6 4 2 2 6 6 6 2 Calcium binding and coiled-coil domain (CALCOCO1) like 2OG-FeII_Oxy PF03171.15 KOO21980.1 - 1.1e-17 64.1 0.0 2.3e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 KOO21980.1 - 2.4e-14 53.8 0.0 3.8e-13 49.9 0.0 2.2 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal EF-hand_1 PF00036.27 KOO21982.1 - 1.9e-12 45.4 0.6 1.9e-05 23.5 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO21982.1 - 4.3e-11 42.7 0.0 3.1e-10 40.0 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO21982.1 - 4.6e-10 38.5 0.4 0.00026 20.6 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO21982.1 - 1.3e-09 36.9 1.1 3.8e-05 22.8 0.4 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO21982.1 - 2.8e-07 30.0 1.4 0.006 16.1 0.1 2.7 1 1 1 2 2 2 2 EF-hand domain pair LRR_4 PF12799.2 KOO21982.1 - 1.4e-05 24.5 1.4 0.026 14.1 0.0 3.2 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO21982.1 - 2.2e-05 24.0 2.2 0.2 11.8 0.1 4.8 5 0 0 5 5 5 1 Leucine Rich repeat LRR_8 PF13855.1 KOO21982.1 - 0.0027 17.4 0.0 2.1 8.1 0.0 2.9 2 0 0 2 2 2 2 Leucine rich repeat Tyr-DNA_phospho PF06087.7 KOO21984.1 - 7.1e-08 31.5 0.0 1.1e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase Hydrolase_like PF13242.1 KOO21984.1 - 3.9e-05 23.2 0.1 9.6e-05 22.0 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.1 KOO21984.1 - 0.024 14.8 0.1 0.08 13.1 0.0 1.9 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Tyr-DNA_phospho PF06087.7 KOO21985.1 - 0.00033 19.4 0.0 0.9 8.0 0.0 3.4 3 1 0 3 3 3 3 Tyrosyl-DNA phosphodiesterase RsbRD_N PF14361.1 KOO21986.1 - 0.07 13.5 0.1 1.1 9.6 0.0 3.0 3 0 0 3 3 3 0 RsbT co-antagonist protein rsbRD N-terminal domain EMP70 PF02990.11 KOO21987.1 - 4e-190 632.7 5.6 4.8e-190 632.4 3.9 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 Band_7 PF01145.20 KOO21989.1 - 0.47 10.3 7.7 2.6 7.8 5.3 2.0 1 1 0 1 1 1 0 SPFH domain / Band 7 family DUF2508 PF10704.4 KOO21989.1 - 3.9 7.7 8.3 1.1 9.5 3.4 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2508) Ank_2 PF12796.2 KOO21990.1 - 4.9e-23 81.2 0.1 9.2e-13 48.3 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO21990.1 - 9.3e-10 37.8 0.0 0.00074 19.2 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 KOO21990.1 - 1.3e-07 31.6 0.0 3.7e-05 23.8 0.0 3.0 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO21990.1 - 4.6e-05 23.8 0.0 0.0011 19.3 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) ART PF01129.13 KOO21990.1 - 6.3e-05 22.1 0.0 0.00013 21.1 0.0 1.4 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Ank_3 PF13606.1 KOO21990.1 - 8.9e-05 22.3 0.0 0.13 12.5 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat ADPrib_exo_Tox PF03496.9 KOO21990.1 - 0.00045 19.4 0.0 0.0019 17.4 0.0 2.0 2 0 0 2 2 2 1 ADP-ribosyltransferase exoenzyme SH3_3 PF08239.6 KOO21990.1 - 0.0013 18.8 0.0 0.0032 17.6 0.0 1.7 1 0 0 1 1 1 1 Bacterial SH3 domain zf-C4H2 PF10146.4 KOO21990.1 - 0.073 13.0 1.7 0.26 11.3 0.4 2.2 2 0 0 2 2 2 0 Zinc finger-containing protein SlyX PF04102.7 KOO21990.1 - 0.14 12.5 3.6 0.83 10.0 2.5 2.5 1 0 0 1 1 1 0 SlyX PC-Esterase PF13839.1 KOO21991.1 - 3.6e-06 27.0 0.0 6.1e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p BLUF PF04940.7 KOO21994.1 - 0.00017 21.2 0.0 0.00027 20.5 0.0 1.3 1 0 0 1 1 1 1 Sensors of blue-light using FAD RBM39linker PF15519.1 KOO21994.1 - 0.067 13.4 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein DnaJ PF00226.26 KOO21995.1 - 0.00053 19.6 0.0 0.00088 18.9 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain DDE_3 PF13358.1 KOO21996.1 - 1.2e-13 51.0 0.0 1.7e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_29 PF13551.1 KOO21996.1 - 1.6e-05 25.0 0.0 3.2e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 KOO21996.1 - 0.0004 19.9 0.3 0.0068 16.0 0.0 2.5 2 1 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 KOO21996.1 - 0.0093 15.9 0.2 0.09 12.7 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_31 PF13560.1 KOO21996.1 - 0.073 13.2 2.7 0.55 10.4 0.0 3.0 3 0 0 3 3 3 0 Helix-turn-helix domain SLBP_RNA_bind PF15247.1 KOO21998.1 - 3.8e-25 87.4 4.4 5.6e-25 86.9 3.1 1.2 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain MMPL PF03176.10 KOO21999.1 - 1.6e-49 168.4 14.8 5.2e-26 91.1 0.4 2.7 2 1 0 2 2 2 2 MMPL family MR_MLE_C PF13378.1 KOO22000.1 - 3.3e-26 91.4 0.0 1.9e-25 88.9 0.0 2.1 2 0 0 2 2 2 1 Enolase C-terminal domain-like MR_MLE PF01188.16 KOO22000.1 - 7.1e-14 52.0 0.0 1.8e-13 50.7 0.0 1.7 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MR_MLE_N PF02746.11 KOO22000.1 - 1.3e-12 47.7 0.1 2.8e-12 46.6 0.0 1.6 2 0 0 2 2 2 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Rootletin PF15035.1 KOO22001.1 - 0.84 9.5 33.9 0.14 12.1 4.5 3.8 2 1 2 4 4 4 0 Ciliary rootlet component, centrosome cohesion DUF4094 PF13334.1 KOO22001.1 - 0.94 9.9 9.7 1.8 9.0 1.8 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) DUF972 PF06156.8 KOO22001.1 - 2.6 8.4 27.1 1.1 9.6 1.1 4.1 2 1 2 4 4 4 0 Protein of unknown function (DUF972) WXG100 PF06013.7 KOO22001.1 - 2.6 8.0 15.3 1.2 9.1 1.8 3.6 3 1 0 3 3 3 0 Proteins of 100 residues with WXG DivIVA PF05103.8 KOO22001.1 - 8.9 6.3 26.9 0.49 10.4 0.5 3.4 2 1 1 3 3 3 0 DivIVA protein DUF4201 PF13870.1 KOO22002.1 - 4.1 6.7 7.1 7.9 5.8 0.2 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) UDPG_MGDP_dh_N PF03721.9 KOO22003.1 - 3e-55 186.4 0.1 6.9e-55 185.3 0.0 1.6 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.10 KOO22003.1 - 3e-35 120.5 0.1 2.3e-34 117.7 0.1 2.3 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.14 KOO22003.1 - 1.2e-31 108.7 0.0 3e-31 107.4 0.0 1.8 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain DUF3456 PF11938.3 KOO22003.1 - 0.00014 21.8 2.3 0.002 18.1 0.2 2.5 1 1 1 2 2 2 2 TLR4 regulator and MIR-interacting MSAP Pkinase PF00069.20 KOO22004.1 - 1.9e-47 161.6 0.0 2.5e-47 161.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22004.1 - 3.3e-24 85.3 0.0 4.3e-24 84.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO22004.1 - 0.0034 16.3 0.0 1.4 7.7 0.0 2.5 3 0 0 3 3 3 2 Kinase-like Kdo PF06293.9 KOO22004.1 - 0.11 11.5 0.3 0.21 10.6 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family ubiquitin PF00240.18 KOO22005.1 - 0.0054 16.1 0.0 0.0096 15.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family LIM PF00412.17 KOO22005.1 - 0.017 15.1 0.8 0.12 12.4 0.5 2.2 1 1 0 1 1 1 0 LIM domain EF-hand_1 PF00036.27 KOO22006.1 - 1.6e-07 30.1 6.0 0.0022 17.1 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO22006.1 - 1.9e-06 27.9 3.4 6.7e-05 22.9 0.3 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO22006.1 - 1.9e-06 26.9 10.6 0.00012 21.2 0.5 2.9 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO22006.1 - 2.3e-06 26.9 1.2 0.077 12.9 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO22006.1 - 0.0017 17.9 1.7 0.17 11.5 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO22006.1 - 0.13 12.2 0.3 17 5.4 0.0 2.4 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF711 PF05167.7 KOO22008.1 - 1e-66 225.3 0.0 1.3e-66 224.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised ACR (DUF711) TFIIF_beta PF02270.10 KOO22010.1 - 6.4e-17 62.2 0.0 4.4e-16 59.5 0.0 1.9 1 1 0 1 1 1 1 Transcription initiation factor IIF, beta subunit CbbQ_C PF08406.5 KOO22011.1 - 0.12 12.3 3.2 0.16 12.0 0.4 2.3 1 1 2 3 3 3 0 CbbQ/NirQ/NorQ C-terminal HSCB_C PF07743.8 KOO22011.1 - 1 9.8 10.5 0.047 14.1 2.3 2.4 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain DUF4140 PF13600.1 KOO22011.1 - 1.4 9.4 5.8 4.5 7.7 0.2 2.5 1 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) IncA PF04156.9 KOO22011.1 - 7.5 6.0 12.9 9.9e+02 -0.9 8.6 2.3 1 1 0 1 1 1 0 IncA protein Pkinase PF00069.20 KOO22012.1 - 5.8e-55 186.2 0.0 6.6e-55 186.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22012.1 - 1.8e-34 119.0 0.0 2.2e-34 118.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO22012.1 - 0.00013 21.0 0.0 0.00023 20.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO22012.1 - 0.015 15.0 0.3 0.015 15.0 0.2 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family CCDC66 PF15236.1 KOO22013.1 - 9.8e-08 31.7 31.5 9.8e-08 31.7 21.8 4.1 4 0 0 4 4 4 1 Coiled-coil domain-containing protein 66 Reo_sigmaC PF04582.7 KOO22014.1 - 9.8 5.2 27.6 0.62 9.1 8.0 3.1 2 1 1 3 3 3 0 Reovirus sigma C capsid protein Hen1_L PF12623.2 KOO22015.1 - 0.046 12.4 0.1 0.092 11.4 0.0 1.5 1 0 0 1 1 1 0 RNA repair, ligase-Pnkp-associating, region of Hen1 bZIP_1 PF00170.16 KOO22015.1 - 0.057 13.3 0.2 0.3 11.0 0.1 2.3 1 0 0 1 1 1 0 bZIP transcription factor DUF2681 PF10883.3 KOO22015.1 - 0.078 13.1 0.8 11 6.2 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Lebercilin PF15619.1 KOO22015.1 - 0.084 12.2 2.1 0.086 12.2 0.1 2.0 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF1843 PF08898.5 KOO22015.1 - 0.22 11.6 9.0 1 9.4 0.1 4.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1843) FKBP_C PF00254.23 KOO22016.1 - 2.4e-26 91.5 0.0 4.5e-26 90.7 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase UBA PF00627.26 KOO22016.1 - 5.9e-05 22.7 0.0 9.4e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 UBA/TS-N domain 2OG-FeII_Oxy_3 PF13640.1 KOO22017.1 - 1.2e-07 32.1 0.0 2.1e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.1 KOO22018.1 - 1e-05 25.9 0.0 2e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Methyltransf_3 PF01596.12 KOO22019.1 - 2.8e-16 59.2 0.0 3.8e-16 58.7 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.1 KOO22019.1 - 3.8e-09 37.3 0.0 6.1e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO22019.1 - 0.0012 19.4 0.0 0.0018 18.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 KOO22019.1 - 0.0014 18.2 0.0 0.0018 17.8 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_26 PF13659.1 KOO22019.1 - 0.003 17.5 0.0 0.0042 17.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DSHCT PF08148.7 KOO22020.1 - 1.4e-35 122.1 0.0 2.5e-35 121.3 0.0 1.4 1 0 0 1 1 1 1 DSHCT (NUC185) domain Helicase_C PF00271.26 KOO22020.1 - 1.1e-08 34.7 0.0 3.1e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Homeobox PF00046.24 KOO22020.1 - 0.041 13.4 0.8 4.4 6.9 0.0 3.6 4 0 0 4 4 4 0 Homeobox domain Pkinase PF00069.20 KOO22021.1 - 1.9e-59 200.9 0.0 3.2e-59 200.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22021.1 - 3.8e-36 124.4 0.0 5.5e-36 123.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO22021.1 - 1.6e-05 23.9 0.0 3.4e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO22021.1 - 0.001 18.8 0.1 0.0072 16.0 0.1 2.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family HEAT_2 PF13646.1 KOO22021.1 - 0.0015 18.7 0.1 0.011 15.9 0.0 2.5 1 1 1 2 2 2 1 HEAT repeats RIO1 PF01163.17 KOO22021.1 - 0.0025 17.2 0.0 0.0049 16.2 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Seadorna_VP7 PF07387.6 KOO22021.1 - 0.023 13.5 0.0 0.042 12.6 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Pox_ser-thr_kin PF05445.6 KOO22021.1 - 0.14 10.9 0.0 0.2 10.4 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DNA_pol_E_B PF04042.11 KOO22022.1 - 3.4e-42 144.0 0.1 4.5e-42 143.6 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B RIIa PF02197.12 KOO22022.1 - 0.012 15.0 0.3 2.9 7.3 0.0 2.7 3 0 0 3 3 3 0 Regulatory subunit of type II PKA R-subunit UDG PF03167.14 KOO22023.1 - 3.3e-23 81.8 0.0 4.4e-23 81.4 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Tropomyosin PF00261.15 KOO22024.1 - 0.62 9.1 35.5 0.29 10.1 8.2 3.2 2 1 0 3 3 3 0 Tropomyosin DUF3250 PF11618.3 KOO22024.1 - 2.1 8.5 3.8 31 4.8 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3250) TFIIA PF03153.8 KOO22024.1 - 7.8 6.2 12.2 11 5.8 8.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RRM_1 PF00076.17 KOO22025.1 - 9.2e-20 70.0 0.0 2.2e-19 68.8 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO22025.1 - 9.9e-16 57.4 0.0 5.2e-14 51.9 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO22025.1 - 4.8e-10 39.1 0.0 1.1e-09 38.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 KOO22025.1 - 0.0038 16.9 0.0 0.0064 16.2 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif NPV_P10 PF05531.7 KOO22025.1 - 0.26 11.5 6.3 10 6.4 2.4 3.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein FliD_C PF07195.7 KOO22025.1 - 0.47 9.7 7.5 3.2 6.9 0.4 2.6 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Baculo_PEP_C PF04513.7 KOO22025.1 - 1.1 9.1 4.3 1.8 8.4 1.8 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus LMBR1 PF04791.11 KOO22025.1 - 8 4.9 5.0 17 3.8 3.5 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein DAP_epimerase PF01678.14 KOO22026.1 - 8.6e-54 180.6 0.0 4.2e-33 113.8 0.0 2.0 2 0 0 2 2 2 2 Diaminopimelate epimerase UDPGP PF01704.13 KOO22027.1 - 1.2e-12 47.0 0.0 1.7e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Hira PF07569.6 KOO22028.1 - 0.14 11.3 0.1 0.17 11.0 0.1 1.1 1 0 0 1 1 1 0 TUP1-like enhancer of split FAA_hydrolase PF01557.13 KOO22029.1 - 9.7e-57 191.9 0.0 1.1e-56 191.7 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Proteasome PF00227.21 KOO22031.1 - 2.3e-48 164.0 0.1 3e-48 163.6 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 KOO22031.1 - 2.2e-15 55.6 0.1 3.5e-15 55.0 0.1 1.3 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature TTL PF03133.10 KOO22032.1 - 2.1e-51 174.5 0.0 2.8e-51 174.1 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATP-grasp_4 PF13535.1 KOO22032.1 - 0.00015 21.5 0.0 0.00023 20.9 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.12 KOO22032.1 - 0.00048 19.4 0.0 0.00074 18.8 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATPgrasp_ST PF14397.1 KOO22032.1 - 0.00088 18.4 0.0 0.0017 17.5 0.0 1.4 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp RimK PF08443.6 KOO22032.1 - 0.0012 18.3 0.0 0.0019 17.7 0.0 1.4 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATPgrasp_Ter PF15632.1 KOO22032.1 - 0.04 12.6 0.0 0.065 11.9 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.9 KOO22032.1 - 0.041 13.7 0.0 0.11 12.2 0.0 1.6 2 0 0 2 2 2 0 ATP-grasp domain ATP-grasp PF02222.17 KOO22032.1 - 0.042 13.2 0.0 0.06 12.7 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain Dala_Dala_lig_C PF07478.8 KOO22032.1 - 0.077 12.3 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus Tic22 PF04278.7 KOO22033.1 - 8.7e-07 28.4 0.1 0.00015 21.0 0.2 2.1 2 0 0 2 2 2 2 Tic22-like family Ala_racemase_N PF01168.15 KOO22034.1 - 3.3e-45 154.3 0.1 4e-45 154.0 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Senescence PF06911.7 KOO22035.1 - 4e-18 65.7 7.0 4.8e-18 65.4 4.5 1.3 1 1 0 1 1 1 1 Senescence-associated protein PP-binding PF00550.20 KOO22036.1 - 1.5e-14 53.9 0.3 2.2e-14 53.4 0.2 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.1 KOO22036.1 - 0.0001 22.2 0.6 0.00016 21.5 0.4 1.5 1 1 0 1 1 1 1 Acyl-carrier DUF1493 PF07377.7 KOO22036.1 - 0.034 14.2 0.0 0.044 13.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) Ank PF00023.25 KOO22037.1 - 3.8e-16 57.9 1.4 5.9e-08 32.1 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.2 KOO22037.1 - 5.4e-15 55.5 0.3 1.2e-14 54.3 0.2 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) EF-hand_1 PF00036.27 KOO22037.1 - 1.2e-11 42.9 1.6 0.01 15.0 0.1 4.4 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.1 KOO22037.1 - 2e-10 40.6 1.1 0.0015 18.6 0.2 3.9 3 1 0 3 3 3 2 EF-hand domain pair Ank_4 PF13637.1 KOO22037.1 - 7.4e-10 39.0 3.4 1.7e-07 31.5 0.4 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO22037.1 - 4e-09 36.4 8.5 4e-06 26.8 0.2 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) EF-hand_5 PF13202.1 KOO22037.1 - 2.4e-08 32.9 3.7 0.35 10.2 0.0 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 KOO22037.1 - 6.1e-07 28.8 2.4 0.34 10.8 0.0 4.3 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.1 KOO22037.1 - 2.6e-06 26.9 2.9 0.35 10.5 0.7 4.5 3 1 0 3 3 3 2 EF-hand domain pair Ank_3 PF13606.1 KOO22037.1 - 5.5e-06 26.1 0.2 0.4 11.0 0.1 3.8 3 0 0 3 3 3 2 Ankyrin repeat EF-hand_10 PF14788.1 KOO22037.1 - 0.00024 20.6 2.3 0.45 10.2 0.2 2.5 2 0 0 2 2 2 2 EF hand MRI PF15325.1 KOO22039.1 - 0.61 11.0 9.4 0.97 10.4 5.8 1.9 1 1 1 2 2 2 0 Modulator of retrovirus infection Esterase PF00756.15 KOO22040.1 - 2.5e-47 161.4 0.0 3.6e-47 160.8 0.0 1.2 1 0 0 1 1 1 1 Putative esterase ADH_zinc_N PF00107.21 KOO22040.1 - 4.6e-23 81.1 0.0 1e-22 80.0 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOO22040.1 - 1e-20 73.5 0.8 2.5e-20 72.2 0.5 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Abhydrolase_5 PF12695.2 KOO22040.1 - 2.1e-05 24.3 1.2 3.2e-05 23.7 0.1 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO22040.1 - 0.01 15.7 1.8 0.017 15.0 0.6 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase family Methyltransf_18 PF12847.2 KOO22040.1 - 0.029 14.9 0.0 0.11 13.1 0.0 2.1 1 0 0 1 1 1 0 Methyltransferase domain TrkA_N PF02254.13 KOO22040.1 - 0.033 14.1 0.0 0.075 13.0 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Peptidase_S9 PF00326.16 KOO22040.1 - 0.069 12.3 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family 2-Hacid_dh_C PF02826.14 KOO22040.1 - 0.079 12.1 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ThiF PF00899.16 KOO22040.1 - 0.15 11.8 0.1 0.45 10.3 0.1 1.9 2 0 0 2 2 2 0 ThiF family PrmA PF06325.8 KOO22040.1 - 0.2 10.7 0.1 0.37 9.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Pyr_redox_3 PF13738.1 KOO22041.1 - 2e-16 60.6 0.0 3.2e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 KOO22041.1 - 4.8e-13 48.7 0.0 9.3e-13 47.8 0.0 1.4 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FMO-like PF00743.14 KOO22041.1 - 2.5e-12 45.7 0.0 1.8e-11 42.9 0.0 1.9 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.9 KOO22041.1 - 2.4e-05 24.3 0.0 4.5e-05 23.4 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 KOO22041.1 - 0.012 14.5 0.0 0.024 13.5 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Shikimate_DH PF01488.15 KOO22041.1 - 0.016 15.3 0.0 0.027 14.5 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.22 KOO22041.1 - 0.071 13.5 0.0 0.18 12.1 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF2338 PF10100.4 KOO22041.1 - 0.1 10.9 0.0 0.13 10.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2338) CAML PF14963.1 KOO22042.1 - 0.067 12.5 0.2 0.11 11.8 0.1 1.3 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand DUF843 PF05814.6 KOO22042.1 - 0.96 9.2 5.7 5.7 6.8 1.6 2.8 2 1 0 2 2 2 0 Baculovirus protein of unknown function (DUF843) Ferric_reduct PF01794.14 KOO22042.1 - 3.1 7.8 14.8 15 5.6 0.1 3.0 1 1 1 2 2 2 0 Ferric reductase like transmembrane component 2OG-FeII_Oxy_3 PF13640.1 KOO22043.1 - 2.7e-16 59.9 0.2 4.5e-16 59.1 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO22043.1 - 5.3e-09 36.2 0.1 7.8e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ion_trans_2 PF07885.11 KOO22044.1 - 9.6e-09 34.8 0.6 9.6e-09 34.8 0.4 2.1 2 0 0 2 2 2 1 Ion channel Ion_trans PF00520.26 KOO22044.1 - 0.001 18.3 0.3 0.0019 17.4 0.2 1.4 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.24 KOO22045.1 - 3.1e-17 62.1 0.4 3e-09 36.5 0.1 3.9 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Ion_trans PF00520.26 KOO22045.1 - 9.1e-05 21.7 0.5 9.1e-05 21.7 0.3 3.1 3 1 0 3 3 3 1 Ion transport protein Ion_trans_2 PF07885.11 KOO22045.1 - 0.0056 16.3 0.5 0.0056 16.3 0.3 3.0 3 0 0 3 3 3 2 Ion channel Fez1 PF06818.10 KOO22045.1 - 0.43 10.5 0.3 1.9 8.4 0.0 1.9 2 0 0 2 2 2 0 Fez1 Filamin PF00630.14 KOO22046.1 - 3.3e-09 37.2 0.1 1.7e-06 28.5 0.0 2.1 2 0 0 2 2 2 2 Filamin/ABP280 repeat Big_1 PF02369.11 KOO22046.1 - 0.02 14.7 0.5 0.04 13.8 0.3 1.6 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) Filamin PF00630.14 KOO22047.1 - 8.8e-13 48.7 0.0 0.00019 21.9 0.0 3.2 2 1 0 3 3 3 3 Filamin/ABP280 repeat LRR_6 PF13516.1 KOO22048.1 - 0.0018 18.1 0.0 0.018 15.0 0.0 2.4 3 0 0 3 3 3 1 Leucine Rich repeat PC-Esterase PF13839.1 KOO22049.1 - 0.1 12.3 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p Lipase_GDSL_2 PF13472.1 KOO22049.1 - 0.19 11.8 2.7 1.8 8.6 1.8 2.2 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family FA_hydroxylase PF04116.8 KOO22051.1 - 0.019 15.3 3.0 0.026 14.8 2.1 1.4 1 0 0 1 1 1 0 Fatty acid hydroxylase superfamily Git3_C PF11970.3 KOO22052.1 - 0.33 10.7 2.9 1.7 8.4 0.1 2.4 2 1 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term Zip PF02535.17 KOO22053.1 - 6.9e-14 51.5 13.9 9.5e-12 44.5 0.2 2.1 2 0 0 2 2 2 2 ZIP Zinc transporter cNMP_binding PF00027.24 KOO22053.1 - 6.4e-09 35.5 0.0 6.2e-05 22.7 0.0 2.5 1 1 1 2 2 2 2 Cyclic nucleotide-binding domain BCCT PF02028.12 KOO22054.1 - 0.059 11.6 0.0 0.062 11.5 0.0 1.1 1 0 0 1 1 1 0 BCCT family transporter Moulting_cycle PF04870.11 KOO22055.1 - 0.051 12.6 0.1 0.064 12.3 0.0 1.1 1 0 0 1 1 1 0 Moulting cycle EF-hand_1 PF00036.27 KOO22056.1 - 2.3e-22 76.5 0.6 0.00037 19.6 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO22056.1 - 1.9e-19 67.7 0.8 0.00097 18.8 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO22056.1 - 1.2e-16 59.2 2.5 0.012 14.9 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO22056.1 - 1.8e-16 60.0 0.4 1.2e-05 25.3 0.0 3.4 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.1 KOO22056.1 - 9.7e-14 50.7 0.6 0.0081 15.7 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain pair Pkinase PF00069.20 KOO22057.1 - 1.7e-55 187.9 0.0 2.6e-55 187.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22057.1 - 1.9e-27 95.9 0.0 2.6e-27 95.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO22057.1 - 8.1e-07 28.2 0.0 2.2e-06 26.8 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.6 KOO22057.1 - 0.018 13.8 0.5 0.062 12.1 0.4 1.8 1 1 0 1 1 1 0 Seadornavirus VP7 WD40 PF00400.27 KOO22059.1 - 5.1e-21 73.7 9.0 0.019 14.8 0.2 9.2 8 1 0 8 8 8 6 WD domain, G-beta repeat Nucleoporin_N PF08801.6 KOO22059.1 - 0.00013 20.8 0.0 0.19 10.4 0.0 2.6 2 0 0 2 2 2 2 Nup133 N terminal like Nuc_sug_transp PF04142.10 KOO22061.1 - 4.2e-45 153.7 5.9 5.9e-45 153.2 4.1 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter TPT PF03151.11 KOO22061.1 - 3.4e-06 26.7 8.5 0.00014 21.5 3.2 2.5 2 2 0 2 2 2 2 Triose-phosphate Transporter family UAA PF08449.6 KOO22061.1 - 1.1e-05 24.5 6.0 1.9e-05 23.7 4.2 1.4 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.15 KOO22061.1 - 0.0003 20.8 3.1 0.0003 20.8 2.1 3.1 3 1 0 3 3 3 1 EamA-like transporter family EmrE PF13536.1 KOO22061.1 - 0.021 15.0 2.9 0.021 15.0 2.0 2.9 2 1 0 2 2 2 0 Multidrug resistance efflux transporter Mog1 PF04603.7 KOO22063.1 - 3.4e-14 53.0 0.0 6.3e-14 52.1 0.0 1.4 1 0 0 1 1 1 1 Ran-interacting Mog1 protein TPR_2 PF07719.12 KOO22063.1 - 1.7e-06 27.4 8.1 3e-05 23.6 1.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO22063.1 - 3.4e-06 27.5 9.1 0.024 15.3 0.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO22063.1 - 5.3e-06 26.6 9.9 0.48 10.7 0.0 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOO22063.1 - 1.2e-05 25.4 11.7 0.19 12.4 0.0 5.7 4 2 2 6 6 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO22063.1 - 1.4e-05 24.6 4.4 0.022 14.4 0.2 4.4 4 0 0 4 4 4 1 TPR repeat TPR_7 PF13176.1 KOO22063.1 - 0.00016 21.2 0.0 0.042 13.6 0.0 3.2 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOO22063.1 - 0.00044 20.1 2.1 0.012 15.5 0.0 3.3 3 1 0 3 3 3 1 Tetratricopeptide repeat ApoL PF05461.6 KOO22063.1 - 0.0013 18.0 0.3 0.0019 17.5 0.2 1.1 1 0 0 1 1 1 1 Apolipoprotein L TPR_8 PF13181.1 KOO22063.1 - 0.0016 18.0 3.9 0.018 14.7 0.5 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO22063.1 - 0.002 17.6 1.4 0.002 17.6 1.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.1 KOO22063.1 - 0.0047 16.0 1.1 2.1 7.3 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO22063.1 - 0.0059 16.4 0.6 0.44 10.4 0.1 2.6 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.1 KOO22063.1 - 0.024 14.7 1.2 0.24 11.5 0.1 3.1 3 1 1 4 4 4 0 Tetratricopeptide repeat Apc3 PF12895.2 KOO22063.1 - 0.027 14.6 2.2 0.31 11.2 0.2 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 KOO22063.1 - 0.068 13.6 4.2 0.66 10.5 0.4 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat DUF2012 PF09430.5 KOO22064.1 - 1.1e-18 67.1 0.0 2.5e-18 66.0 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF2012) CarboxypepD_reg PF13620.1 KOO22064.1 - 8.8e-06 25.6 0.0 1.3e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CitMHS PF03600.11 KOO22064.1 - 0.023 13.2 0.1 0.023 13.2 0.1 1.1 1 0 0 1 1 1 0 Citrate transporter DUF4480 PF13715.1 KOO22064.1 - 0.042 13.9 0.0 0.059 13.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4480) EF-hand_1 PF00036.27 KOO22066.1 - 1.4e-23 80.3 9.1 2.7e-05 23.1 0.3 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO22066.1 - 1.3e-20 73.2 3.0 2.2e-10 40.5 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO22066.1 - 2.6e-20 70.4 6.5 0.0011 18.7 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO22066.1 - 1.5e-19 68.3 7.2 0.00033 19.8 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO22066.1 - 5.7e-17 61.0 8.5 1.8e-05 24.2 0.2 3.5 2 2 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO22066.1 - 0.0013 18.7 0.1 2.7 8.0 0.0 3.4 2 1 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region A_deaminase PF00962.17 KOO22067.1 - 5.7e-27 94.5 0.0 5.7e-17 61.6 0.0 3.3 2 2 0 2 2 2 2 Adenosine/AMP deaminase Ndufs5 PF10200.4 KOO22068.1 - 0.0032 17.4 0.1 0.0079 16.1 0.1 1.7 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa Guanylate_cyc PF00211.15 KOO22069.1 - 7.5e-09 35.2 0.0 1.3e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Ion_trans PF00520.26 KOO22069.1 - 0.00011 21.5 2.5 0.00011 21.5 1.7 2.1 2 0 0 2 2 2 1 Ion transport protein Galactosyl_T PF01762.16 KOO22070.1 - 0.00027 20.6 0.0 0.00042 19.9 0.0 1.3 1 0 0 1 1 1 1 Galactosyltransferase Nucleos_tra2_C PF07662.8 KOO22072.1 - 3.1e-57 193.4 11.4 3e-53 180.4 3.9 2.8 3 0 0 3 3 3 2 Na+ dependent nucleoside transporter C-terminus Methyltransf_23 PF13489.1 KOO22073.1 - 0.021 14.5 0.0 0.035 13.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain ACC_epsilon PF13822.1 KOO22073.1 - 0.034 14.4 0.8 0.034 14.4 0.5 2.1 2 0 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit Na_Ca_ex PF01699.19 KOO22074.1 - 9.3e-38 128.9 20.9 3.6e-20 71.9 6.6 2.5 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Calx-beta PF03160.9 KOO22074.1 - 1.6e-32 111.4 0.2 4.1e-16 58.7 0.0 2.5 2 0 0 2 2 2 2 Calx-beta domain Fasciclin PF02469.17 KOO22075.1 - 2.8e-72 240.7 0.1 6.9e-35 119.8 0.0 2.3 2 0 0 2 2 2 2 Fasciclin domain AAA PF00004.24 KOO22075.1 - 4.1e-39 133.7 0.0 8.1e-39 132.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 KOO22075.1 - 2.7e-05 23.3 0.0 8.2e-05 21.7 0.0 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KOO22075.1 - 4.4e-05 23.6 0.1 0.0026 17.9 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 KOO22075.1 - 6.1e-05 22.7 0.2 0.00027 20.6 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.8 KOO22075.1 - 9.2e-05 21.3 0.0 0.00028 19.7 0.0 1.8 1 0 0 1 1 1 1 TIP49 C-terminus AAA_17 PF13207.1 KOO22075.1 - 0.00012 22.8 0.0 0.00031 21.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOO22075.1 - 0.00014 21.9 2.4 0.0021 18.0 0.1 3.5 4 1 0 4 4 2 1 AAA ATPase domain IstB_IS21 PF01695.12 KOO22075.1 - 0.00016 21.1 0.0 0.00034 20.0 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.9 KOO22075.1 - 0.00027 20.9 0.0 0.00058 19.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Vps4_C PF09336.5 KOO22075.1 - 0.00075 19.3 0.0 0.0018 18.1 0.0 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain Blt1 PF12754.2 KOO22075.1 - 0.0014 18.2 0.1 0.6 9.6 0.0 2.2 2 0 0 2 2 2 1 Cell-cycle control medial ring component AAA_19 PF13245.1 KOO22075.1 - 0.0015 18.2 6.1 0.0018 17.9 0.0 3.7 4 0 0 4 4 3 1 Part of AAA domain AAA_25 PF13481.1 KOO22075.1 - 0.0079 15.6 1.0 0.3 10.4 0.2 2.6 1 1 1 2 2 2 1 AAA domain Mg_chelatase PF01078.16 KOO22075.1 - 0.009 15.1 0.2 0.023 13.8 0.1 1.6 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 KOO22075.1 - 0.016 15.0 0.0 0.037 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 KOO22075.1 - 0.017 15.3 0.0 0.033 14.3 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.1 KOO22075.1 - 0.031 14.1 0.0 0.051 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 KOO22075.1 - 0.054 12.5 0.0 0.099 11.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin PhoH PF02562.11 KOO22075.1 - 0.055 12.6 3.0 0.19 10.9 0.0 2.8 3 0 0 3 3 3 0 PhoH-like protein HpaB_N PF11794.3 KOO22075.1 - 0.06 12.7 5.9 2 7.7 0.3 2.3 2 0 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase N terminal AAA_18 PF13238.1 KOO22075.1 - 0.074 13.3 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 KOO22075.1 - 0.078 12.4 0.1 0.94 8.9 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain Parvo_NS1 PF01057.12 KOO22075.1 - 0.089 11.6 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ResIII PF04851.10 KOO22075.1 - 0.096 12.5 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Arch_ATPase PF01637.13 KOO22075.1 - 0.16 11.6 0.0 13 5.4 0.0 2.7 1 1 0 2 2 2 0 Archaeal ATPase Cloacin_immun PF03513.9 KOO22075.1 - 0.21 11.6 0.2 7.6 6.6 0.0 2.3 2 0 0 2 2 2 0 Cloacin immunity protein DUF211 PF02680.9 KOO22075.1 - 0.57 10.0 8.6 5.7 6.8 1.0 2.6 2 0 0 2 2 2 0 Uncharacterized ArCR, COG1888 TIG PF01833.19 KOO22076.1 - 1.4e-14 53.8 3.9 3.2e-06 27.0 1.0 3.6 3 0 0 3 3 3 3 IPT/TIG domain TIG PF01833.19 KOO22077.1 - 7.4e-79 259.8 49.8 3.4e-08 33.3 0.1 18.1 16 3 0 16 16 16 15 IPT/TIG domain Exostosin PF03016.10 KOO22078.1 - 6.9e-14 51.5 0.0 3.2e-06 26.4 0.0 2.1 1 1 1 2 2 2 2 Exostosin family Filamin PF00630.14 KOO22079.1 - 1.7e-25 89.4 0.0 1.8e-06 28.4 0.0 6.5 6 0 0 6 6 6 5 Filamin/ABP280 repeat SH3_3 PF08239.6 KOO22079.1 - 0.0082 16.3 0.0 0.045 13.9 0.0 2.4 2 0 0 2 2 2 1 Bacterial SH3 domain Drf_FH1 PF06346.7 KOO22080.1 - 0.09 12.2 6.1 0.1 12.0 4.2 1.1 1 0 0 1 1 1 0 Formin Homology Region 1 PKD_channel PF08016.7 KOO22081.1 - 1.6e-17 63.1 6.1 3.9e-16 58.4 3.1 2.2 2 0 0 2 2 2 2 Polycystin cation channel Ion_trans PF00520.26 KOO22081.1 - 0.00012 21.3 9.5 0.00012 21.3 6.6 1.6 2 0 0 2 2 2 1 Ion transport protein Band_7 PF01145.20 KOO22082.1 - 0.023 14.6 4.1 0.44 10.4 2.8 2.6 1 1 0 1 1 1 0 SPFH domain / Band 7 family Myosin_head PF00063.16 KOO22083.1 - 1.1e-141 473.1 0.0 1.1e-140 469.8 0.0 2.1 1 1 0 1 1 1 1 Myosin head (motor domain) AAA_22 PF13401.1 KOO22083.1 - 6.7e-05 23.0 0.0 0.0024 18.0 0.0 3.0 3 0 0 3 3 3 1 AAA domain PRK PF00485.13 KOO22083.1 - 0.064 12.8 0.1 0.54 9.7 0.1 2.1 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family UPF0079 PF02367.12 KOO22083.1 - 0.1 12.1 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 VCBS PF13517.1 KOO22084.1 - 2.6e-11 43.6 5.4 0.013 15.8 0.0 5.3 4 1 1 5 5 5 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO22084.1 - 2.1e-10 39.9 12.2 7e-06 25.5 0.3 4.7 4 0 0 4 4 4 2 FG-GAP repeat EF-hand_7 PF13499.1 KOO22084.1 - 8.4e-07 29.0 0.6 3.2e-06 27.1 0.0 2.3 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO22084.1 - 0.013 15.0 1.1 0.19 11.3 0.0 3.0 3 0 0 3 3 3 0 EF-hand domain pair TIG PF01833.19 KOO22084.1 - 0.014 15.3 0.0 1.6 8.7 0.0 2.5 2 0 0 2 2 2 0 IPT/TIG domain EF-hand_1 PF00036.27 KOO22084.1 - 0.14 11.5 0.0 0.14 11.5 0.0 4.6 6 0 0 6 6 6 0 EF hand EF-hand_5 PF13202.1 KOO22084.1 - 0.22 10.9 0.1 0.22 10.9 0.0 4.0 4 0 0 4 4 4 0 EF hand EF-hand_6 PF13405.1 KOO22084.1 - 2.5 8.2 6.5 2.7 8.1 0.0 3.6 4 0 0 4 4 4 0 EF-hand domain Saccharop_dh PF03435.13 KOO22085.1 - 4.8e-08 32.3 0.0 5.8e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Saccharopine dehydrogenase Shikimate_DH PF01488.15 KOO22085.1 - 0.023 14.8 0.0 0.068 13.2 0.0 1.9 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase SPOR PF05036.8 KOO22085.1 - 0.11 12.6 0.1 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Sporulation related domain Ank_2 PF12796.2 KOO22086.1 - 6.9e-58 192.9 26.1 1.6e-19 70.0 1.1 3.9 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.25 KOO22086.1 - 8.4e-25 85.3 16.0 5.6e-06 25.8 0.1 6.4 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.1 KOO22086.1 - 2.8e-23 81.4 11.7 4.8e-08 32.9 1.0 4.9 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO22086.1 - 7.4e-23 80.4 4.7 6.2e-09 36.1 0.0 4.1 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO22086.1 - 1.8e-13 49.2 3.9 0.011 15.8 0.0 5.3 6 0 0 6 6 6 4 Ankyrin repeat WWE PF02825.15 KOO22087.1 - 6.8e-17 60.6 0.6 1.5e-08 33.8 0.0 2.8 2 1 0 2 2 2 2 WWE domain ART PF01129.13 KOO22087.1 - 3.7e-09 36.0 0.0 9.7e-09 34.6 0.0 1.7 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Peptidase_S9 PF00326.16 KOO22088.1 - 0.0035 16.5 0.0 0.0041 16.3 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase family Ank PF00023.25 KOO22089.1 - 5.4e-65 212.1 21.8 1.4e-08 34.0 0.1 9.1 9 0 0 9 9 9 8 Ankyrin repeat Ank_2 PF12796.2 KOO22089.1 - 1.6e-59 198.2 23.6 4.4e-19 68.6 1.1 4.6 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO22089.1 - 2.7e-59 196.5 8.5 6.2e-10 39.3 0.0 6.3 2 1 6 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO22089.1 - 1.8e-41 139.1 22.6 2.2e-12 46.8 0.2 7.8 2 1 7 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO22089.1 - 8.7e-39 127.6 11.1 5.7e-05 22.9 0.0 8.7 7 1 1 8 8 8 8 Ankyrin repeat THUMP PF02926.12 KOO22089.1 - 2.5e-05 24.2 0.0 5.5e-05 23.0 0.0 1.5 2 0 0 2 2 2 1 THUMP domain DHDPS PF00701.17 KOO22089.1 - 0.037 12.6 0.1 0.065 11.8 0.1 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate synthetase family Calreticulin PF00262.13 KOO22090.1 - 1.5e-34 119.2 0.1 1.8e-34 119.0 0.1 1.0 1 0 0 1 1 1 1 Calreticulin family Metallophos PF00149.23 KOO22091.1 - 1.5e-41 141.9 0.4 2e-41 141.6 0.3 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase LRR_6 PF13516.1 KOO22092.1 - 1.2e-37 123.7 66.6 0.13 12.3 0.0 29.2 34 0 0 34 34 32 10 Leucine Rich repeat LRR_1 PF00560.28 KOO22092.1 - 1e-22 76.6 10.3 2.3 8.5 0.0 18.9 22 0 0 22 22 19 1 Leucine Rich Repeat LRR_4 PF12799.2 KOO22092.1 - 4.2e-09 35.8 38.6 0.028 14.0 0.1 14.4 15 1 0 15 15 15 2 Leucine Rich repeats (2 copies) EF-hand_1 PF00036.27 KOO22092.1 - 1.8e-07 29.9 1.1 0.006 15.8 0.0 3.6 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 KOO22092.1 - 2.8e-07 30.5 0.2 3.6e-06 27.0 0.1 2.8 2 0 0 2 2 2 1 EF-hand domain pair LRR_7 PF13504.1 KOO22092.1 - 1.1e-06 27.8 35.0 56 4.6 0.3 16.2 17 0 0 17 17 17 0 Leucine rich repeat LRR_8 PF13855.1 KOO22092.1 - 9.1e-05 22.1 36.5 7.5 6.3 0.3 14.7 13 4 3 16 16 15 2 Leucine rich repeat EF-hand_6 PF13405.1 KOO22092.1 - 0.00015 21.3 0.7 0.089 12.7 0.0 3.9 2 1 1 3 3 3 1 EF-hand domain EF-hand_8 PF13833.1 KOO22092.1 - 0.0016 18.0 0.3 0.012 15.1 0.1 2.8 2 0 0 2 2 2 1 EF-hand domain pair SpoU_sub_bind PF08032.7 KOO22092.1 - 0.0057 16.8 4.2 39 4.5 0.1 6.1 6 1 0 6 6 6 0 RNA 2'-O ribose methyltransferase substrate binding DUF2202 PF09968.4 KOO22092.1 - 0.21 11.2 0.1 52 3.4 0.0 3.4 3 0 0 3 3 3 0 Uncharacterized protein domain (DUF2202) SPARC_Ca_bdg PF10591.4 KOO22092.1 - 0.28 11.2 0.1 0.89 9.6 0.0 1.8 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region dUTPase PF00692.14 KOO22093.1 - 3.5e-43 146.1 0.0 4.1e-43 145.9 0.0 1.0 1 0 0 1 1 1 1 dUTPase DLH PF01738.13 KOO22094.1 - 7e-24 84.3 0.0 8.7e-24 84.0 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 KOO22094.1 - 3.9e-06 26.6 0.1 6.2e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 KOO22094.1 - 0.00081 19.1 0.2 0.0035 17.1 0.0 2.1 2 1 0 2 2 2 1 Putative lysophospholipase Abhydrolase_6 PF12697.2 KOO22094.1 - 0.018 14.9 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family AXE1 PF05448.7 KOO22094.1 - 0.071 11.5 0.0 0.29 9.5 0.0 1.8 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Kinesin PF00225.18 KOO22096.1 - 3.6e-80 269.1 0.0 9.7e-40 136.2 0.3 3.7 3 0 0 3 3 3 3 Kinesin motor domain SURF4 PF02077.10 KOO22098.1 - 4.6e-26 91.7 0.1 4.6e-19 68.8 0.0 2.0 2 0 0 2 2 2 2 SURF4 family DoxX PF07681.7 KOO22098.1 - 0.025 14.9 1.2 0.025 14.9 0.9 2.7 3 0 0 3 3 3 0 DoxX GST_C_2 PF13410.1 KOO22099.1 - 4.3e-05 23.3 0.0 0.00012 21.8 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 KOO22099.1 - 0.00016 21.5 0.0 0.00026 20.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 KOO22099.1 - 0.00035 20.6 0.0 0.0012 19.0 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 KOO22099.1 - 0.0031 17.9 0.0 0.0064 16.9 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Beta-lactamase PF00144.19 KOO22100.1 - 2.7e-21 75.9 5.0 7.9e-21 74.4 3.5 1.6 1 1 0 1 1 1 1 Beta-lactamase DUF805 PF05656.9 KOO22101.1 - 0.0035 17.1 0.8 0.53 10.1 0.4 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF805) DUF1469 PF07332.6 KOO22101.1 - 0.3 10.8 8.0 1.2 8.9 0.8 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1469) LRR_6 PF13516.1 KOO22103.1 - 3.9e-11 41.8 0.0 0.0015 18.3 0.0 3.3 3 0 0 3 3 3 2 Leucine Rich repeat MR_MLE_C PF13378.1 KOO22103.1 - 0.059 13.3 0.1 0.083 12.8 0.0 1.4 1 1 0 1 1 1 0 Enolase C-terminal domain-like LRR_1 PF00560.28 KOO22103.1 - 0.068 13.2 0.0 64 4.1 0.0 3.0 3 0 0 3 3 3 0 Leucine Rich Repeat YycC PF14174.1 KOO22103.1 - 0.073 12.7 0.1 20 4.9 0.0 2.6 3 0 0 3 3 3 0 YycC-like protein Syntaxin-18_N PF10496.4 KOO22103.1 - 0.19 11.6 0.2 4.5 7.1 0.0 2.6 3 0 0 3 3 3 0 SNARE-complex protein Syntaxin-18 N-terminus CbiG_N PF11760.3 KOO22103.1 - 1.1 9.0 4.0 30 4.4 0.1 3.0 3 0 0 3 3 3 0 Cobalamin synthesis G N-terminal Vitellogenin_N PF01347.17 KOO22105.1 - 0.0023 16.2 0.3 0.0036 15.5 0.2 1.2 1 0 0 1 1 1 1 Lipoprotein amino terminal region IQ PF00612.22 KOO22105.1 - 9.9 6.1 19.3 0.96 9.2 1.1 4.6 4 0 0 4 4 4 0 IQ calmodulin-binding motif zf-RING_2 PF13639.1 KOO22106.1 - 2.2e-10 40.1 13.8 3.8e-10 39.4 9.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 KOO22106.1 - 1.1e-07 31.4 9.3 1.7e-07 30.8 6.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO22106.1 - 1.2e-06 28.0 14.5 2e-06 27.3 10.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO22106.1 - 2.8e-06 27.2 14.3 4.7e-06 26.5 9.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 KOO22106.1 - 4.9e-06 26.3 13.6 8.3e-06 25.5 9.4 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 KOO22106.1 - 4.9e-05 22.9 12.0 7.9e-05 22.2 8.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 KOO22106.1 - 5e-05 22.9 9.1 9.2e-05 22.0 6.3 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.2 KOO22106.1 - 5.6e-05 23.1 9.9 0.00013 21.9 6.9 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 KOO22106.1 - 0.004 16.9 3.1 0.0091 15.8 2.2 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.3 KOO22106.1 - 0.63 9.5 6.1 1 8.9 4.2 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.1 KOO22106.1 - 1.1 9.1 6.7 2.6 7.8 4.6 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-P11 PF03854.9 KOO22106.1 - 5.2 6.6 9.4 27 4.3 5.8 2.5 2 1 1 3 3 3 0 P-11 zinc finger IQ PF00612.22 KOO22107.1 - 0.00079 18.8 0.5 0.002 17.6 0.3 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif PseudoU_synth_1 PF01416.15 KOO22108.1 - 1.9e-23 82.8 0.0 9e-11 42.1 0.0 2.7 2 1 0 2 2 2 2 tRNA pseudouridine synthase SBBP PF06739.6 KOO22109.1 - 5.3e-15 54.9 23.6 0.00011 21.8 0.3 6.5 6 0 0 6 6 6 5 Beta-propeller repeat CcmD PF04995.9 KOO22109.1 - 0.017 14.8 0.7 0.017 14.8 0.5 2.2 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) DUF2681 PF10883.3 KOO22109.1 - 0.34 11.1 0.1 0.58 10.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) DUF2625 PF10946.3 KOO22109.1 - 3 6.7 8.7 2.6 6.9 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function DUF2625 DUF21 PF01595.15 KOO22110.1 - 5.3e-39 133.4 6.5 8.7e-39 132.7 4.5 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF21 CBS PF00571.23 KOO22110.1 - 1.1e-15 57.1 1.9 2e-07 30.6 0.1 2.5 2 0 0 2 2 2 2 CBS domain CorC_HlyC PF03471.12 KOO22110.1 - 1.6e-15 56.6 0.1 3.7e-15 55.4 0.0 1.6 1 0 0 1 1 1 1 Transporter associated domain SapC PF07277.6 KOO22111.1 - 0.003 16.9 0.4 0.0055 16.0 0.3 1.5 1 0 0 1 1 1 1 SapC Endonuc_Holl PF10107.4 KOO22111.1 - 5.6 6.6 6.1 13 5.4 0.1 2.3 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase Glu_synthase PF01645.12 KOO22112.1 - 2.4e-150 500.5 1.0 3.1e-149 496.8 0.0 2.1 2 0 0 2 2 2 1 Conserved region in glutamate synthase GATase_2 PF00310.16 KOO22112.1 - 8.8e-110 366.8 0.0 1.3e-109 366.2 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_syn_central PF04898.9 KOO22112.1 - 4.8e-102 341.1 0.0 1e-101 340.0 0.0 1.6 1 0 0 1 1 1 1 Glutamate synthase central domain GXGXG PF01493.14 KOO22112.1 - 1.4e-52 177.6 2.9 2.2e-52 176.9 2.0 1.3 1 0 0 1 1 1 1 GXGXG motif DUF2681 PF10883.3 KOO22113.1 - 1.7 8.8 5.6 0.51 10.5 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) LRR_6 PF13516.1 KOO22114.1 - 0.0035 17.2 0.1 0.039 14.0 0.0 2.6 3 0 0 3 3 3 1 Leucine Rich repeat BSD PF03909.12 KOO22115.1 - 2.4e-05 23.9 0.0 5.5e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 BSD domain AAA_18 PF13238.1 KOO22115.1 - 0.071 13.4 0.1 0.18 12.1 0.1 1.6 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 KOO22115.1 - 0.09 13.6 0.4 0.27 12.0 0.1 2.2 2 1 0 2 2 2 0 AAA domain APS_kinase PF01583.15 KOO22115.1 - 0.16 11.6 0.1 0.31 10.6 0.1 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase Utp12 PF04003.7 KOO22116.1 - 0.0084 16.0 2.7 0.0091 15.8 0.1 2.2 2 0 0 2 2 2 1 Dip2/Utp12 Family PmbA_TldD PF01523.11 KOO22116.1 - 0.041 13.1 0.4 0.096 11.9 0.0 1.7 1 1 0 1 1 1 0 Putative modulator of DNA gyrase Tricorn_PDZ PF14685.1 KOO22117.1 - 2.8e-05 23.8 0.7 0.026 14.2 0.0 3.0 2 1 1 3 3 3 2 Tricorn protease PDZ domain PDZ PF00595.19 KOO22117.1 - 0.00036 20.6 0.5 0.001 19.1 0.1 2.0 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO22117.1 - 0.031 14.1 0.1 0.85 9.5 0.0 2.3 2 0 0 2 2 2 0 PDZ domain RRM_1 PF00076.17 KOO22118.1 - 0.00065 19.2 0.0 0.0011 18.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO22118.1 - 0.0012 18.7 0.0 0.0023 17.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF3328 PF11807.3 KOO22118.1 - 0.1 12.2 0.2 0.16 11.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) Nup96 PF12110.3 KOO22119.1 - 3.9e-06 26.1 0.0 6.9e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 Nuclear protein 96 FHA PF00498.21 KOO22120.1 - 9.1e-14 51.3 0.0 1.6e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 FHA domain Drf_GBD PF06371.8 KOO22120.1 - 1.8e-06 27.4 0.0 2.7e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain Neurochondrin PF05536.6 KOO22120.1 - 0.04 12.2 0.0 0.073 11.3 0.0 1.4 1 0 0 1 1 1 0 Neurochondrin DUF3361 PF11841.3 KOO22120.1 - 0.061 13.0 0.0 5 6.8 0.0 2.4 2 1 0 3 3 3 0 Domain of unknown function (DUF3361) EF-hand_7 PF13499.1 KOO22121.1 - 3e-15 56.0 0.7 8.4e-14 51.4 0.0 2.7 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO22121.1 - 3.2e-12 44.8 0.7 4.7e-05 22.3 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO22121.1 - 3.6e-11 41.8 3.3 0.00018 20.7 0.0 3.9 5 0 0 5 5 5 2 EF hand EF-hand_6 PF13405.1 KOO22121.1 - 1.3e-09 37.1 0.2 0.00013 21.5 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO22121.1 - 6.2e-08 32.1 0.9 4.2e-07 29.4 0.1 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.1 KOO22121.1 - 4.7e-05 23.2 0.0 8.8e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain Peptidase_M17 PF00883.16 KOO22122.1 - 2.3e-40 138.4 0.0 3.5e-40 137.7 0.0 1.3 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain LRR_6 PF13516.1 KOO22123.1 - 1.1e-19 68.2 16.8 0.00081 19.2 0.1 8.6 9 0 0 9 9 9 6 Leucine Rich repeat LRR_4 PF12799.2 KOO22123.1 - 2.9e-07 29.9 4.9 0.029 14.0 0.0 5.2 2 1 5 7 7 7 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO22123.1 - 1.2e-06 27.6 0.8 9 6.7 0.0 6.5 7 0 0 7 7 7 2 Leucine Rich Repeat LRR_7 PF13504.1 KOO22123.1 - 0.00088 19.0 5.8 17 6.1 0.0 6.7 8 0 0 8 8 8 1 Leucine rich repeat LRR_8 PF13855.1 KOO22123.1 - 0.0034 17.0 5.9 0.52 10.1 0.0 4.8 4 2 1 5 5 5 2 Leucine rich repeat LRR_4 PF12799.2 KOO22124.1 - 6.5e-23 79.8 30.7 8.8e-07 28.4 0.8 9.0 5 2 5 10 10 10 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO22124.1 - 2.3e-18 65.6 32.7 4.3e-07 29.5 0.4 8.3 6 2 0 7 7 7 5 Leucine rich repeat LRR_1 PF00560.28 KOO22124.1 - 1.7e-10 39.4 24.5 0.044 13.8 0.1 12.0 11 0 0 11 11 11 2 Leucine Rich Repeat LRR_6 PF13516.1 KOO22124.1 - 6.7e-10 37.9 37.9 0.97 9.7 0.0 13.9 14 1 0 14 14 14 4 Leucine Rich repeat Ras PF00071.17 KOO22124.1 - 1.5e-07 30.9 0.0 3.3e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO22124.1 - 0.00045 20.7 0.0 0.0017 18.8 0.0 2.1 2 0 0 2 2 1 1 Miro-like protein Arf PF00025.16 KOO22124.1 - 0.006 15.8 0.0 0.014 14.6 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family Med3 PF11593.3 KOO22124.1 - 0.0069 15.6 6.9 0.015 14.6 4.8 1.4 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal AAA PF00004.24 KOO22124.1 - 0.011 15.9 0.0 0.046 13.9 0.0 2.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Gtr1_RagA PF04670.7 KOO22124.1 - 0.069 12.2 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region TruB_N PF01509.13 KOO22124.1 - 0.13 12.4 0.1 0.39 10.8 0.1 1.8 1 0 0 1 1 1 0 TruB family pseudouridylate synthase (N terminal domain) LRR_7 PF13504.1 KOO22124.1 - 0.46 10.8 43.3 4.3 7.9 0.1 12.7 14 0 0 14 14 13 0 Leucine rich repeat Fer4_12 PF13353.1 KOO22125.1 - 1.2e-10 41.6 0.0 1.9e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 4Fe-4S single cluster domain Radical_SAM PF04055.16 KOO22125.1 - 1e-08 35.5 0.0 1.4e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.1 KOO22125.1 - 2.1e-08 34.2 0.0 3.3e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain Tat PF00539.13 KOO22125.1 - 0.15 11.7 2.5 0.27 10.9 1.7 1.3 1 0 0 1 1 1 0 Transactivating regulatory protein (Tat) ThiF PF00899.16 KOO22127.1 - 4.5e-49 165.7 0.1 7.5e-34 116.4 0.0 2.9 2 0 0 2 2 2 2 ThiF family UBACT PF02134.16 KOO22127.1 - 1.8e-31 107.4 0.1 3.2e-26 90.6 0.1 2.8 3 0 0 3 3 3 2 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 KOO22127.1 - 2.8e-16 58.6 0.0 6.4e-16 57.4 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site LRR_6 PF13516.1 KOO22127.1 - 9.2e-10 37.5 0.0 0.067 13.2 0.0 4.9 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.2 KOO22127.1 - 1.5e-05 24.4 0.0 0.2 11.3 0.0 2.9 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO22127.1 - 0.24 11.1 0.0 14 5.5 0.0 3.0 2 0 0 2 2 2 0 Leucine rich repeat CYTH PF01928.16 KOO22128.1 - 2.6e-09 37.0 0.0 3.6e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 CYTH domain DinB_2 PF12867.2 KOO22128.1 - 0.44 10.9 5.8 0.25 11.7 0.9 2.1 2 0 0 2 2 2 0 DinB superfamily KSR1-SAM PF13543.1 KOO22129.1 - 0.12 12.1 0.5 0.38 10.5 0.0 2.0 2 0 0 2 2 2 0 SAM like domain present in kinase suppressor RAS 1 SelR PF01641.13 KOO22131.1 - 2.1e-16 59.7 0.1 5.2e-16 58.4 0.1 1.7 1 0 0 1 1 1 1 SelR domain GAF_2 PF13185.1 KOO22131.1 - 0.00062 20.2 0.1 0.0013 19.2 0.0 1.5 1 0 0 1 1 1 1 GAF domain Endonuclease_7 PF02945.10 KOO22131.1 - 0.062 13.0 1.4 1.4 8.6 1.0 2.4 1 1 0 1 1 1 0 Recombination endonuclease VII Yippee-Mis18 PF03226.9 KOO22131.1 - 0.18 11.8 2.8 1.1 9.3 1.9 2.1 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly TPR_11 PF13414.1 KOO22132.1 - 4.6e-40 135.0 27.8 1.4e-13 50.2 2.4 4.7 2 1 3 5 5 5 5 TPR repeat TPR_1 PF00515.23 KOO22132.1 - 1.6e-35 119.2 9.2 3.1e-06 26.5 0.0 7.4 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.12 KOO22132.1 - 1.9e-32 108.5 15.7 4.4e-05 23.0 0.0 7.6 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.1 KOO22132.1 - 1e-29 100.1 17.9 1.9e-05 24.4 0.3 8.4 7 1 0 8 8 8 6 Tetratricopeptide repeat TPR_12 PF13424.1 KOO22132.1 - 9.7e-25 86.3 21.5 6.5e-09 35.6 2.6 4.7 1 1 4 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.1 KOO22132.1 - 2.5e-21 74.2 33.0 5.3e-05 23.4 0.0 7.8 2 1 4 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.1 KOO22132.1 - 1.1e-20 71.7 9.9 0.00071 19.1 0.8 7.0 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.1 KOO22132.1 - 3.5e-18 65.7 40.8 7.2e-07 29.7 7.2 5.9 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.1 KOO22132.1 - 8e-15 53.4 3.1 0.0076 15.9 0.0 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat Lipase_3 PF01764.20 KOO22132.1 - 6.8e-14 51.6 0.0 1.6e-13 50.4 0.0 1.7 1 0 0 1 1 1 1 Lipase (class 3) TPR_19 PF14559.1 KOO22132.1 - 6.3e-11 42.4 19.4 8.1e-05 22.8 0.1 5.0 3 2 1 5 5 4 3 Tetratricopeptide repeat TPR_10 PF13374.1 KOO22132.1 - 1.5e-09 37.4 40.5 0.0044 16.9 0.1 7.4 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_9 PF13371.1 KOO22132.1 - 1e-07 31.6 12.2 0.00053 19.7 0.1 5.0 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_15 PF13429.1 KOO22132.1 - 4.9e-05 22.5 9.6 0.057 12.4 1.2 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_4 PF07721.9 KOO22132.1 - 0.00041 20.5 31.3 1.1 9.9 0.0 8.2 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOO22132.1 - 0.00058 20.1 13.1 12 6.5 0.9 6.5 5 1 1 6 6 6 0 Tetratricopeptide repeat Abhydrolase_5 PF12695.2 KOO22132.1 - 0.0021 17.8 1.7 0.0062 16.2 0.0 2.4 2 1 0 2 2 2 1 Alpha/beta hydrolase family Methyltransf_18 PF12847.2 KOO22132.1 - 0.024 15.1 0.0 0.15 12.6 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain MIT PF04212.13 KOO22132.1 - 3.7 7.4 10.9 36 4.3 0.0 4.1 3 2 0 3 3 2 0 MIT (microtubule interacting and transport) domain RRM_1 PF00076.17 KOO22133.1 - 0.0004 19.9 0.1 0.0012 18.3 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO22133.1 - 0.0045 16.9 0.0 0.018 15.0 0.0 2.0 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO22133.1 - 0.0055 16.5 0.0 0.013 15.2 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DEAD PF00270.24 KOO22134.1 - 9.4e-46 155.3 0.0 2.3e-45 154.1 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO22134.1 - 3.4e-17 62.0 0.0 7.6e-17 60.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 KOO22134.1 - 0.00071 18.4 0.0 0.0008 18.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain AAA_22 PF13401.1 KOO22134.1 - 0.017 15.2 0.0 2.2 8.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain Helicase_IV_N PF12462.3 KOO22134.1 - 0.39 10.3 2.7 0.73 9.4 1.9 1.4 1 0 0 1 1 1 0 DNA helicase IV / RNA helicase N terminal Pep_deformylase PF01327.16 KOO22135.1 - 4.7e-50 169.0 0.0 6.1e-50 168.6 0.0 1.1 1 0 0 1 1 1 1 Polypeptide deformylase Flu_M1_C PF08289.6 KOO22136.1 - 0.11 12.4 0.1 0.18 11.8 0.1 1.3 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain Aminotran_3 PF00202.16 KOO22136.1 - 0.58 8.9 3.4 0.76 8.5 2.3 1.2 1 0 0 1 1 1 0 Aminotransferase class-III Glyco_hydro_76 PF03663.9 KOO22137.1 - 3.4e-13 49.7 21.7 3e-11 43.3 15.1 3.3 1 1 0 1 1 1 1 Glycosyl hydrolase family 76 Somatomedin_B PF01033.12 KOO22137.1 - 0.33 10.9 16.7 0.044 13.7 6.3 3.3 2 1 0 2 2 2 0 Somatomedin B domain WD40 PF00400.27 KOO22138.1 - 5.9e-63 206.6 20.8 6.6e-10 38.4 0.5 10.3 10 0 0 10 10 10 10 WD domain, G-beta repeat Utp12 PF04003.7 KOO22138.1 - 1.2e-13 50.9 0.7 2.9e-13 49.7 0.5 1.7 1 0 0 1 1 1 1 Dip2/Utp12 Family Nup160 PF11715.3 KOO22138.1 - 0.00067 17.9 5.5 0.024 12.7 0.2 3.9 3 2 0 3 3 3 2 Nucleoporin Nup120/160 PQQ_2 PF13360.1 KOO22138.1 - 0.66 9.3 8.7 1.9 7.8 0.1 3.3 2 1 0 3 3 3 0 PQQ-like domain KOW PF00467.24 KOO22139.1 - 0.051 13.3 0.3 0.13 12.0 0.2 1.7 1 0 0 1 1 1 0 KOW motif NYN PF01936.13 KOO22140.1 - 1.5e-16 61.0 0.0 3.2e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 NYN domain DOPA_dioxygen PF08883.6 KOO22140.1 - 0.064 13.3 0.0 0.27 11.3 0.0 1.9 2 0 0 2 2 2 0 Dopa 4,5-dioxygenase family Pkinase PF00069.20 KOO22141.1 - 4.1e-16 58.9 0.0 9.1e-16 57.7 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22141.1 - 3.9e-07 29.3 0.0 9.8e-07 28.1 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase IQ PF00612.22 KOO22143.1 - 1.3e-09 36.8 11.0 0.027 14.0 0.4 4.6 4 0 0 4 4 4 3 IQ calmodulin-binding motif HEAT_2 PF13646.1 KOO22143.1 - 1.3e-05 25.4 1.3 2.8e-05 24.2 0.1 2.2 1 1 0 1 1 1 1 HEAT repeats Arm PF00514.18 KOO22143.1 - 0.00048 19.8 0.3 0.00048 19.8 0.2 3.1 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat HEAT PF02985.17 KOO22143.1 - 0.0014 18.5 0.1 0.0053 16.7 0.1 2.1 1 0 0 1 1 1 1 HEAT repeat HEAT_EZ PF13513.1 KOO22143.1 - 0.0018 18.7 0.2 0.0018 18.7 0.1 2.7 3 1 1 4 4 4 1 HEAT-like repeat DUF1353 PF07087.6 KOO22143.1 - 0.043 13.2 0.0 0.092 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1353) Peptidase_S10 PF00450.17 KOO22145.1 - 1.6e-82 277.8 0.0 1.9e-82 277.6 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Glycos_transf_1 PF00534.15 KOO22146.1 - 0.0053 16.1 0.0 0.0087 15.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 KOO22146.1 - 0.012 15.8 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 Cupin_4 PF08007.7 KOO22150.1 - 2.2e-25 89.6 0.0 2.5e-25 89.4 0.0 1.0 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.1 KOO22150.1 - 2.5e-05 23.9 0.0 0.00017 21.1 0.0 1.9 1 1 0 1 1 1 1 Cupin-like domain Sulfotransfer_1 PF00685.22 KOO22151.1 - 0.013 14.7 0.0 0.027 13.7 0.0 1.4 1 1 0 1 1 1 0 Sulfotransferase domain HCV_capsid PF01543.12 KOO22151.1 - 0.096 12.6 0.3 0.096 12.6 0.2 1.9 2 0 0 2 2 2 0 Hepatitis C virus capsid protein Abhydrolase_5 PF12695.2 KOO22152.1 - 7.5e-13 48.4 0.3 3.2e-11 43.1 0.0 2.6 3 0 0 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO22152.1 - 2.2e-05 24.4 3.2 6e-05 23.0 2.1 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 KOO22152.1 - 0.0051 16.4 0.0 0.0082 15.7 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Peptidase_S9 PF00326.16 KOO22152.1 - 0.054 12.7 0.1 0.11 11.6 0.1 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_1 PF00561.15 KOO22152.1 - 0.07 12.6 0.1 0.11 12.0 0.1 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.20 KOO22152.1 - 0.23 11.0 1.0 0.39 10.3 0.0 1.7 2 0 0 2 2 2 0 Lipase (class 3) Ion_trans_2 PF07885.11 KOO22153.1 - 3.3e-24 84.3 10.1 3.7e-14 52.1 1.9 3.6 4 0 0 4 4 4 2 Ion channel Sgf11 PF08209.6 KOO22153.1 - 5.9e-11 41.4 0.3 1.6e-10 40.0 0.2 1.8 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) Ion_trans PF00520.26 KOO22153.1 - 0.0036 16.5 21.3 0.014 14.6 0.1 3.8 3 1 0 3 3 3 2 Ion transport protein EF-hand_6 PF13405.1 KOO22153.1 - 0.013 15.3 2.0 0.081 12.8 0.3 2.8 2 0 0 2 2 2 0 EF-hand domain EF-hand_7 PF13499.1 KOO22153.1 - 0.016 15.3 1.0 0.04 14.0 0.7 1.6 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.27 KOO22153.1 - 0.03 13.6 0.3 0.03 13.6 0.2 3.5 3 0 0 3 3 3 0 EF hand OSCP PF00213.13 KOO22154.1 - 7.8e-39 133.2 1.8 9.5e-39 133.0 1.2 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit SET PF00856.23 KOO22155.1 - 5.4e-10 39.8 0.1 2.3e-09 37.7 0.0 2.0 2 0 0 2 2 2 1 SET domain MPC PF03650.8 KOO22156.1 - 3.6e-37 126.9 3.9 3.1e-18 65.8 0.2 2.1 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0041) Abhydrolase_6 PF12697.2 KOO22157.1 - 7.3e-07 29.2 0.5 1.3e-06 28.4 0.1 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO22157.1 - 0.00044 20.0 0.0 0.00059 19.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ank_2 PF12796.2 KOO22160.1 - 8.7e-23 80.4 21.5 4.1e-12 46.2 1.9 4.2 2 1 1 4 4 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO22160.1 - 2.6e-18 64.8 19.0 1.4e-05 24.6 0.6 6.0 5 1 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.1 KOO22160.1 - 4.3e-17 61.7 9.0 3.9e-06 26.9 0.1 5.3 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO22160.1 - 4.1e-15 55.8 2.1 5.1e-06 26.8 0.0 3.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) TPR_12 PF13424.1 KOO22160.1 - 5.8e-12 45.3 0.5 5.8e-12 45.3 0.4 5.1 3 1 3 6 6 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOO22160.1 - 1.5e-10 40.5 3.2 1.5e-10 40.5 2.2 4.0 2 1 1 4 4 2 1 TPR repeat Ank_3 PF13606.1 KOO22160.1 - 8.4e-09 34.8 6.7 0.032 14.4 0.0 5.9 6 0 0 6 6 5 2 Ankyrin repeat TPR_1 PF00515.23 KOO22160.1 - 1.7e-07 30.5 4.7 0.0039 16.7 1.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.1 KOO22160.1 - 3.8e-07 29.8 0.3 3.8e-07 29.8 0.2 6.7 7 1 0 7 7 6 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO22160.1 - 2.6e-06 27.9 2.1 2.6e-06 27.9 1.5 9.0 6 1 4 10 10 5 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO22160.1 - 0.0017 18.0 3.3 0.0017 18.0 2.3 5.3 5 1 1 6 6 4 2 Tetratricopeptide repeat PDZ PF00595.19 KOO22160.1 - 0.0023 18.0 0.1 0.0061 16.7 0.1 1.7 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) TPR_7 PF13176.1 KOO22160.1 - 0.023 14.4 7.0 0.35 10.7 0.0 4.3 3 0 0 3 3 3 0 Tetratricopeptide repeat GAS PF13851.1 KOO22160.1 - 0.03 13.5 0.9 0.071 12.2 0.6 1.7 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding PDZ_2 PF13180.1 KOO22160.1 - 0.15 11.9 0.0 0.43 10.5 0.0 1.8 1 0 0 1 1 1 0 PDZ domain TMCO5 PF14992.1 KOO22160.1 - 0.38 9.8 2.5 0.58 9.2 1.8 1.2 1 0 0 1 1 1 0 TMCO5 family Rootletin PF15035.1 KOO22160.1 - 0.63 9.9 13.3 0.26 11.2 6.5 2.3 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion AAA_13 PF13166.1 KOO22160.1 - 3.7 5.8 7.0 5.8 5.2 4.9 1.2 1 0 0 1 1 1 0 AAA domain Asp-B-Hydro_N PF05279.6 KOO22161.1 - 1.2 8.8 14.7 1.8 8.3 10.2 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF572 PF04502.8 KOO22161.1 - 6.1 5.9 15.2 7.4 5.6 10.5 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF2586 PF10758.4 KOO22161.1 - 7.3 5.5 23.4 9.6 5.1 15.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2586) Neur_chan_LBD PF02931.18 KOO22163.1 - 4.1e-09 35.9 0.0 3.2e-08 32.9 0.0 2.3 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.11 KOO22163.1 - 0.00039 20.3 1.5 0.00062 19.7 1.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region PARG_cat PF05028.9 KOO22164.1 - 1.8e-74 251.0 0.0 2.3e-74 250.6 0.0 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) Mito_carr PF00153.22 KOO22165.1 - 2.9e-46 155.1 6.7 1.4e-16 59.9 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein CPSase_L_chain PF00289.17 KOO22165.1 - 0.13 12.3 0.0 2.3 8.3 0.0 2.4 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, N-terminal domain Tub PF01167.13 KOO22166.1 - 3.8e-20 71.9 0.0 5.8e-20 71.3 0.0 1.3 1 0 0 1 1 1 1 Tub family Presenilin PF01080.12 KOO22168.1 - 7.1e-71 239.1 18.2 1.2e-47 162.6 2.9 2.0 1 1 1 2 2 2 2 Presenilin PH PF00169.24 KOO22170.1 - 2.3e-06 27.7 0.0 3.2e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 PH domain GSHPx PF00255.14 KOO22170.1 - 0.0047 16.2 0.0 0.0081 15.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione peroxidase Mito_carr PF00153.22 KOO22172.1 - 3e-19 68.5 6.0 4.5e-06 26.2 0.1 3.6 2 1 1 3 3 3 3 Mitochondrial carrier protein OmpH PF03938.9 KOO22173.1 - 0.0087 16.0 9.2 0.012 15.5 6.4 1.1 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) DUF4200 PF13863.1 KOO22173.1 - 0.012 15.5 1.7 0.012 15.5 1.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Rootletin PF15035.1 KOO22173.1 - 0.012 15.6 2.6 0.015 15.2 1.8 1.1 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF812 PF05667.6 KOO22173.1 - 0.019 13.5 3.4 0.023 13.2 2.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Atg14 PF10186.4 KOO22173.1 - 0.042 12.8 3.8 0.051 12.5 2.7 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4140 PF13600.1 KOO22173.1 - 0.15 12.4 7.7 0.31 11.5 1.0 2.2 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF3006 PF11213.3 KOO22173.1 - 0.23 11.2 3.4 1.5 8.6 2.4 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3006) DUF3138 PF11336.3 KOO22173.1 - 0.23 9.6 3.0 0.3 9.2 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF3450 PF11932.3 KOO22173.1 - 0.35 10.1 5.7 0.44 9.7 4.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) APG6 PF04111.7 KOO22173.1 - 0.95 8.4 6.8 1.2 8.1 4.7 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 CENP-Q PF13094.1 KOO22173.1 - 1.6 8.6 8.6 2.4 8.1 5.9 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DivIC PF04977.10 KOO22173.1 - 4.4 6.8 8.4 1.5 8.3 2.4 2.1 2 0 0 2 2 2 0 Septum formation initiator FAD_binding_3 PF01494.14 KOO22174.1 - 8e-18 64.6 0.5 9.9e-10 37.9 0.0 3.0 3 0 0 3 3 3 3 FAD binding domain NAD_binding_8 PF13450.1 KOO22174.1 - 5.7e-06 26.2 0.1 1.4e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 KOO22174.1 - 8.3e-05 21.5 0.1 0.00018 20.4 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 KOO22174.1 - 0.00018 20.5 0.2 0.00018 20.5 0.1 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 KOO22174.1 - 0.001 18.9 0.1 0.0016 18.3 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 KOO22174.1 - 0.021 13.9 0.1 0.032 13.3 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Trp_halogenase PF04820.9 KOO22174.1 - 0.024 13.2 0.0 2.8 6.4 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase HI0933_like PF03486.9 KOO22174.1 - 0.069 11.6 0.0 0.1 11.0 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.12 KOO22174.1 - 0.14 11.1 0.0 0.24 10.4 0.0 1.3 1 0 0 1 1 1 0 Thi4 family SE PF08491.5 KOO22174.1 - 0.17 10.6 0.0 0.26 10.0 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase TPR_MLP1_2 PF07926.7 KOO22175.1 - 0.00077 19.2 9.6 0.001 18.8 6.6 1.1 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein DUF3086 PF11285.3 KOO22175.1 - 0.0015 17.3 1.5 0.0016 17.3 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3086) HOOK PF05622.7 KOO22175.1 - 0.002 16.0 3.5 0.0024 15.7 2.4 1.0 1 0 0 1 1 1 1 HOOK protein GAS PF13851.1 KOO22175.1 - 0.0051 16.0 9.2 0.0058 15.8 6.4 1.1 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Spc7 PF08317.6 KOO22175.1 - 0.015 13.9 8.2 0.02 13.5 5.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein TarH PF02203.10 KOO22175.1 - 0.019 14.8 2.7 0.02 14.7 1.9 1.2 1 0 0 1 1 1 0 Tar ligand binding domain homologue APG6 PF04111.7 KOO22175.1 - 0.028 13.4 6.8 0.032 13.2 4.7 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF465 PF04325.8 KOO22175.1 - 0.036 13.7 5.1 0.85 9.3 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF465) SlyX PF04102.7 KOO22175.1 - 0.037 14.3 2.4 0.044 14.1 0.7 1.8 1 1 1 2 2 2 0 SlyX PMC2NT PF08066.7 KOO22175.1 - 0.042 14.1 1.0 0.22 11.8 0.1 2.0 1 1 1 2 2 2 0 PMC2NT (NUC016) domain Metal_resist PF13801.1 KOO22175.1 - 0.066 13.2 1.8 0.098 12.6 0.7 1.6 1 1 1 2 2 2 0 Heavy-metal resistance Bacillus_HBL PF05791.6 KOO22175.1 - 0.1 11.9 3.1 0.14 11.5 2.2 1.2 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) DUF4220 PF13968.1 KOO22175.1 - 0.15 11.1 1.3 0.16 11.0 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) DUF4208 PF13907.1 KOO22175.1 - 0.15 12.2 5.0 0.44 10.7 0.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4208) Syntaxin-6_N PF09177.6 KOO22175.1 - 0.21 12.0 5.1 0.28 11.6 1.4 2.1 1 1 1 2 2 2 0 Syntaxin 6, N-terminal ADIP PF11559.3 KOO22175.1 - 0.24 11.2 9.6 0.41 10.5 6.6 1.5 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding CorA PF01544.13 KOO22175.1 - 0.46 9.4 3.7 0.55 9.2 2.6 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein IncA PF04156.9 KOO22175.1 - 0.47 10.0 9.4 0.83 9.2 6.5 1.4 1 1 0 1 1 1 0 IncA protein DUF342 PF03961.8 KOO22175.1 - 0.5 8.7 6.5 0.58 8.5 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Atg14 PF10186.4 KOO22175.1 - 0.88 8.4 8.2 0.96 8.3 5.7 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Occludin_ELL PF07303.8 KOO22175.1 - 1 10.1 4.1 1.4 9.6 2.7 1.4 1 1 0 1 1 1 0 Occludin homology domain TPX2 PF06886.6 KOO22175.1 - 2.2 8.4 6.1 5.2 7.2 0.2 2.3 2 0 0 2 2 2 0 Targeting protein for Xklp2 (TPX2) Pox_A_type_inc PF04508.7 KOO22175.1 - 2.7 8.0 6.5 2.8 7.9 2.8 2.4 1 1 1 2 2 2 0 Viral A-type inclusion protein repeat DUF972 PF06156.8 KOO22175.1 - 2.9 8.2 5.7 3.5 8.0 3.5 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Spc24 PF08286.6 KOO22175.1 - 4.7 6.9 8.8 89 2.8 6.1 2.2 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 DUF4140 PF13600.1 KOO22175.1 - 5.7 7.4 7.4 2.5 8.5 2.4 2.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) HSP90 PF00183.13 KOO22176.1 - 1.3e-226 753.2 14.5 1.4e-226 753.0 10.0 1.0 1 0 0 1 1 1 1 Hsp90 protein EAP30 PF04157.11 KOO22176.1 - 0.041 13.0 0.1 0.087 11.9 0.1 1.6 1 0 0 1 1 1 0 EAP30/Vps36 family LOH1CR12 PF10158.4 KOO22176.1 - 0.045 13.5 0.1 0.14 11.9 0.1 1.8 1 0 0 1 1 1 0 Tumour suppressor protein Glu_cyclase_2 PF05096.7 KOO22177.1 - 1.2e-43 149.0 0.1 1.3e-24 86.6 0.0 2.0 1 1 1 2 2 2 2 Glutamine cyclotransferase Aminotran_3 PF00202.16 KOO22178.1 - 8.6e-104 347.0 0.0 1.1e-103 346.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III DNA_ligase_A_N PF04675.9 KOO22179.1 - 6.4e-30 104.2 0.0 1.1e-29 103.5 0.0 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_M PF01068.16 KOO22179.1 - 8.9e-30 103.5 0.0 2.4e-26 92.3 0.0 2.5 1 1 1 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_C PF04679.10 KOO22179.1 - 1.3e-14 54.3 0.0 4.9e-14 52.4 0.0 2.1 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region SopD PF11047.3 KOO22179.1 - 0.011 14.6 0.1 0.017 14.0 0.1 1.2 1 0 0 1 1 1 0 Salmonella outer protein D mRNA_cap_enzyme PF01331.14 KOO22179.1 - 0.034 13.8 0.2 0.7 9.5 0.1 3.2 1 1 0 1 1 1 0 mRNA capping enzyme, catalytic domain EIF4E-T PF10477.4 KOO22179.1 - 0.24 10.1 0.1 1.3 7.7 0.0 2.1 3 0 0 3 3 3 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E CLPTM1 PF05602.7 KOO22180.1 - 2.9e-81 273.4 0.0 3.9e-81 273.0 0.0 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.9 KOO22180.1 - 0.015 14.8 0.5 0.23 11.0 0.0 2.5 2 0 0 2 2 2 0 PQ loop repeat Metallophos PF00149.23 KOO22181.1 - 5.9e-09 35.5 0.1 1.4e-08 34.4 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KOO22181.1 - 1.7e-05 24.7 0.1 5.2e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain AAA PF00004.24 KOO22182.1 - 1.1e-14 54.7 0.0 1.8e-14 54.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOO22182.1 - 8.4e-06 25.9 0.0 0.0011 19.1 0.0 2.6 1 1 0 1 1 1 1 AAA domain EF-hand_6 PF13405.1 KOO22182.1 - 1e-05 25.0 0.1 3.6e-05 23.2 0.0 2.0 2 0 0 2 2 1 1 EF-hand domain EF-hand_5 PF13202.1 KOO22182.1 - 1.1e-05 24.5 1.1 3.2e-05 23.0 0.8 1.8 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KOO22182.1 - 1.3e-05 24.1 0.3 0.00012 21.1 0.1 2.4 2 0 0 2 2 2 1 EF hand Mg_chelatase PF01078.16 KOO22182.1 - 4e-05 22.8 0.2 0.025 13.7 0.1 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI RuvB_N PF05496.7 KOO22182.1 - 0.00012 21.2 0.0 0.00098 18.2 0.0 2.3 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 KOO22182.1 - 0.001 19.8 0.0 0.0049 17.6 0.0 2.2 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.1 KOO22182.1 - 0.0012 18.8 0.4 0.0036 17.3 0.0 2.1 2 1 0 2 2 2 1 AAA ATPase domain EF-hand_7 PF13499.1 KOO22182.1 - 0.0017 18.4 0.1 0.0054 16.8 0.0 1.8 1 1 0 1 1 1 1 EF-hand domain pair Sigma54_activat PF00158.21 KOO22182.1 - 0.0021 17.5 0.0 0.026 13.9 0.0 2.4 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_2 PF07724.9 KOO22182.1 - 0.0026 17.6 0.0 0.0048 16.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_19 PF13245.1 KOO22182.1 - 0.003 17.2 0.8 0.012 15.2 0.1 2.4 2 0 0 2 2 1 1 Part of AAA domain Viral_helicase1 PF01443.13 KOO22182.1 - 0.004 16.7 0.0 0.0064 16.0 0.0 1.2 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.9 KOO22182.1 - 0.0061 16.2 0.0 0.016 14.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF2075 PF09848.4 KOO22182.1 - 0.0098 14.9 0.0 0.051 12.5 0.0 1.9 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_10 PF12846.2 KOO22182.1 - 0.012 15.0 0.1 3.9 6.8 0.0 2.6 1 1 1 3 3 3 0 AAA-like domain AAA_18 PF13238.1 KOO22182.1 - 0.022 15.0 0.0 0.041 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.15 KOO22182.1 - 0.025 14.2 0.0 0.54 9.8 0.0 2.2 2 0 0 2 2 2 0 Adenylylsulphate kinase EF-hand_8 PF13833.1 KOO22182.1 - 0.027 14.0 0.4 0.4 10.3 0.0 3.0 4 0 0 4 4 4 0 EF-hand domain pair Zeta_toxin PF06414.7 KOO22182.1 - 0.062 12.3 0.1 0.44 9.6 0.0 2.2 3 0 0 3 3 3 0 Zeta toxin AAA_28 PF13521.1 KOO22182.1 - 0.077 12.9 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.8 KOO22182.1 - 0.093 11.6 0.0 3.5 6.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) RNA_helicase PF00910.17 KOO22182.1 - 0.21 11.7 0.0 1.4 9.1 0.0 2.1 2 0 0 2 2 2 0 RNA helicase EF-hand_1 PF00036.27 KOO22183.1 - 7.7e-21 71.7 15.6 1.8e-07 29.9 1.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.1 KOO22183.1 - 1.3e-19 68.5 8.0 8.9e-08 31.1 0.2 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO22183.1 - 2.5e-19 67.3 7.2 6.2e-06 25.6 0.1 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO22183.1 - 3.8e-19 68.5 4.0 4.1e-09 36.4 0.1 3.5 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO22183.1 - 1.8e-15 56.2 14.5 7.6e-06 25.4 0.4 4.4 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_10 PF14788.1 KOO22183.1 - 0.0027 17.3 0.8 6.4 6.5 0.0 3.6 3 1 1 4 4 4 1 EF hand p25-alpha PF05517.7 KOO22183.1 - 0.007 16.6 1.9 0.007 16.6 1.3 2.0 2 1 0 2 2 2 1 p25-alpha EF-hand_9 PF14658.1 KOO22183.1 - 0.09 12.7 0.0 0.58 10.1 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain OmpH PF03938.9 KOO22183.1 - 0.55 10.1 12.7 0.068 13.1 2.4 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Hydrolase PF00702.21 KOO22184.1 - 1.5e-19 71.2 0.0 1.2e-17 65.0 0.0 3.1 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO22184.1 - 8.2e-19 68.5 0.0 4e-18 66.2 0.0 2.2 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 KOO22184.1 - 0.00062 18.8 2.6 0.0007 18.6 0.2 2.3 2 0 0 2 2 2 1 E1-E2 ATPase CPSase_L_D2 PF02786.12 KOO22185.1 - 8.8e-104 345.3 0.3 1.2e-78 263.2 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.17 KOO22185.1 - 9.8e-48 160.9 0.0 2e-47 159.9 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.23 KOO22185.1 - 1.6e-40 138.6 0.0 8.4e-40 136.2 0.0 2.1 2 0 0 2 2 2 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.14 KOO22185.1 - 7.4e-40 135.5 0.0 1.8e-39 134.2 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain CPSase_L_chain PF00289.17 KOO22185.1 - 2.2e-38 130.7 0.1 4.1e-19 68.6 0.0 2.7 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, N-terminal domain ATP-grasp_4 PF13535.1 KOO22185.1 - 2.8e-28 98.9 0.7 5.2e-16 58.9 0.1 2.4 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.1 KOO22185.1 - 5.8e-18 64.7 0.4 1.8e-10 40.0 0.1 3.2 3 1 0 3 3 3 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 KOO22185.1 - 1.2e-14 54.0 0.1 1.5e-08 34.1 0.1 2.6 2 0 0 2 2 2 2 ATP-grasp domain MGS PF02142.17 KOO22185.1 - 2.1e-13 49.9 0.0 8.3e-13 48.0 0.0 2.1 2 0 0 2 2 2 1 MGS-like domain Dala_Dala_lig_C PF07478.8 KOO22185.1 - 8.3e-11 41.6 0.2 0.00032 20.1 0.1 2.6 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.9 KOO22185.1 - 4.3e-07 29.9 0.4 0.0006 19.7 0.1 2.6 2 0 0 2 2 2 2 ATP-grasp domain Peptidase_C26 PF07722.8 KOO22185.1 - 4.9e-05 22.8 0.7 0.0085 15.5 0.2 3.4 2 1 0 2 2 2 1 Peptidase C26 Nif11 PF07862.6 KOO22185.1 - 0.0049 16.7 1.0 0.18 11.7 0.0 3.7 5 0 0 5 5 4 1 Nitrogen fixation protein of unknown function RimK PF08443.6 KOO22185.1 - 0.029 13.8 0.0 0.49 9.8 0.1 2.9 3 1 0 3 3 3 0 RimK-like ATP-grasp domain GPS PF01825.16 KOO22186.1 - 2.5e-09 37.1 6.6 4.9e-09 36.1 4.5 1.4 1 0 0 1 1 1 1 Latrophilin/CL-1-like GPS domain cNMP_binding PF00027.24 KOO22187.1 - 1.9e-10 40.3 0.1 7.4e-10 38.5 0.1 1.9 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain AAA_16 PF13191.1 KOO22187.1 - 3.9e-09 36.7 0.2 1.2e-08 35.1 0.2 1.8 1 0 0 1 1 1 1 AAA ATPase domain Guanylate_cyc PF00211.15 KOO22187.1 - 1.4e-05 24.5 0.0 2.9e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain IstB_IS21 PF01695.12 KOO22187.1 - 0.00027 20.4 0.3 0.00069 19.0 0.2 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF815 PF05673.8 KOO22187.1 - 0.001 18.0 0.1 0.0017 17.3 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_28 PF13521.1 KOO22187.1 - 0.0022 17.9 0.2 0.0066 16.4 0.2 1.9 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 KOO22187.1 - 0.0028 17.5 0.9 0.008 16.0 0.2 2.1 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 KOO22187.1 - 0.0065 16.2 0.0 0.016 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Miro PF08477.8 KOO22187.1 - 0.01 16.3 0.0 0.042 14.3 0.0 2.0 2 0 0 2 2 2 0 Miro-like protein AAA_29 PF13555.1 KOO22187.1 - 0.011 15.2 0.1 0.026 14.0 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.22 KOO22187.1 - 0.078 13.2 0.0 0.33 11.2 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_22 PF13401.1 KOO22187.1 - 0.093 12.8 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.14 KOO22187.1 - 0.11 11.7 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain DUF2791 PF10923.3 KOO22187.1 - 0.11 11.1 0.1 0.17 10.4 0.1 1.2 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) MobB PF03205.9 KOO22187.1 - 0.11 12.2 0.0 0.57 9.8 0.0 2.2 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B PKD_channel PF08016.7 KOO22189.1 - 7.5e-30 103.6 14.3 7.5e-30 103.6 9.9 1.5 2 0 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.26 KOO22189.1 - 8.5e-07 28.4 19.2 1.7e-06 27.3 13.3 1.5 1 1 0 1 1 1 1 Ion transport protein Myelin-PO_C PF10570.4 KOO22189.1 - 0.076 13.0 1.1 0.2 11.7 0.7 1.6 1 0 0 1 1 1 0 Myelin-PO cytoplasmic C-term p65 binding region Anoctamin PF04547.7 KOO22190.1 - 1.1e-103 347.3 9.4 1.4e-103 347.0 6.5 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel TPT PF03151.11 KOO22191.1 - 1.4e-16 60.5 4.8 1.4e-16 60.5 3.3 2.9 2 2 0 2 2 2 1 Triose-phosphate Transporter family DUF3318 PF11780.3 KOO22191.1 - 0.091 12.3 1.0 0.17 11.4 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3318) Metallophos PF00149.23 KOO22192.1 - 4.6e-30 104.5 0.0 1.5e-26 93.0 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase DUF4368 PF14287.1 KOO22192.1 - 0.038 13.8 0.0 0.065 13.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4368) PAS_9 PF13426.1 KOO22194.1 - 2.3e-11 43.9 0.0 5.6e-11 42.7 0.0 1.7 2 0 0 2 2 2 1 PAS domain PAS PF00989.19 KOO22194.1 - 0.01 15.6 0.0 0.025 14.3 0.0 1.7 1 0 0 1 1 1 0 PAS fold Na_Ca_ex PF01699.19 KOO22195.1 - 2.6e-23 82.1 26.3 1.4e-13 50.6 2.8 2.9 3 0 0 3 3 3 2 Sodium/calcium exchanger protein DNA_pol_A PF00476.15 KOO22196.1 - 2e-59 201.1 0.0 5e-59 199.8 0.0 1.6 1 1 0 1 1 1 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.15 KOO22196.1 - 3.6e-09 36.3 0.0 1.2e-08 34.5 0.0 1.9 1 1 0 1 1 1 1 3'-5' exonuclease 2OG-FeII_Oxy PF03171.15 KOO22197.1 - 0.06 13.6 0.1 0.18 12.1 0.1 1.9 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Ank_2 PF12796.2 KOO22198.1 - 2.8e-34 117.3 0.1 6e-15 55.3 0.0 2.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO22198.1 - 1.3e-22 78.4 1.3 3.5e-06 26.5 0.0 3.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 KOO22198.1 - 4.5e-19 68.0 1.6 2.8e-12 46.4 0.0 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO22198.1 - 1.4e-16 60.4 0.0 1e-10 41.8 0.0 2.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO22198.1 - 7.8e-15 53.5 0.1 0.003 17.6 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat DUF3263 PF11662.3 KOO22198.1 - 0.1 12.0 0.1 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3263) DUF1840 PF08895.6 KOO22198.1 - 2.1 8.4 4.6 0.7 9.9 1.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) TauE PF01925.14 KOO22199.1 - 2.9e-16 59.6 33.6 2.1e-15 56.8 21.6 2.6 1 1 0 1 1 1 1 Sulfite exporter TauE/SafE Glyco_transf_90 PF05686.7 KOO22200.1 - 1.2e-32 113.1 0.0 5e-32 111.0 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.1 KOO22200.1 - 0.00033 20.8 0.0 0.0011 19.2 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Ribosomal_S7 PF00177.16 KOO22201.1 - 1.1e-26 93.1 0.0 1.4e-26 92.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e DUF4231 PF14015.1 KOO22202.1 - 0.005 16.8 0.7 0.1 12.5 0.0 3.0 2 2 0 2 2 2 1 Protein of unknown function (DUF4231) CytB6-F_Fe-S PF08802.5 KOO22203.1 - 5.1e-18 64.7 1.1 1.5e-17 63.3 0.7 1.8 1 0 0 1 1 1 1 Cytochrome B6-F complex Fe-S subunit Rieske PF00355.21 KOO22203.1 - 1.7e-17 62.7 0.2 2.6e-17 62.1 0.2 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain PH_2 PF08458.5 KOO22204.1 - 0.021 14.7 0.0 0.039 13.8 0.0 1.4 1 0 0 1 1 1 0 Plant pleckstrin homology-like region IQ PF00612.22 KOO22204.1 - 0.025 14.1 2.6 0.025 14.1 1.8 2.7 2 0 0 2 2 2 0 IQ calmodulin-binding motif 2-Hacid_dh_C PF02826.14 KOO22205.1 - 6.9e-38 129.5 0.0 9.6e-38 129.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.12 KOO22205.1 - 0.00018 21.8 0.2 0.00079 19.8 0.0 2.3 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh PF00389.25 KOO22205.1 - 0.08 12.4 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain SepQ PF06622.6 KOO22205.1 - 0.11 11.4 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 SepQ protein AdoHcyase_NAD PF00670.16 KOO22205.1 - 0.17 11.7 0.0 0.31 10.8 0.0 1.3 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Aminotran_3 PF00202.16 KOO22206.1 - 6.3e-79 265.2 0.0 7.4e-79 265.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.16 KOO22206.1 - 3.8e-06 26.2 0.0 6.1e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase SelR PF01641.13 KOO22207.1 - 1.4e-39 134.5 0.0 3.3e-39 133.3 0.1 1.5 2 0 0 2 2 2 1 SelR domain Methyltransf_16 PF10294.4 KOO22207.1 - 2.3e-13 49.9 0.0 3.5e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 KOO22207.1 - 8.8e-05 23.0 0.0 0.0002 21.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOO22207.1 - 0.0021 17.4 0.3 0.0042 16.4 0.2 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 KOO22207.1 - 0.025 14.5 2.6 0.049 13.6 0.5 2.2 2 0 0 2 2 2 0 Methyltransferase domain Met_10 PF02475.11 KOO22207.1 - 0.036 13.6 0.0 0.057 12.9 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein GidB PF02527.10 KOO22207.1 - 0.12 11.4 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G ABC_transp_aux PF09822.4 KOO22208.1 - 5.9e-08 32.4 0.0 8.7e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 ABC-type uncharacterized transport system DDOST_48kD PF03345.9 KOO22208.1 - 0.0037 15.8 0.0 1.7 7.1 0.0 2.1 2 0 0 2 2 2 2 Oligosaccharyltransferase 48 kDa subunit beta DUF4159 PF13709.1 KOO22208.1 - 0.0054 15.8 0.0 0.02 14.0 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4159) SHIPPO-rpt PF07004.7 KOO22209.1 - 4.5e-08 33.6 13.5 0.71 10.8 0.2 5.9 6 0 0 6 6 6 5 Sperm-tail PG-rich repeat Guanylate_cyc_2 PF09778.4 KOO22210.1 - 1.3e-45 155.2 0.0 1.7e-45 154.8 0.0 1.1 1 0 0 1 1 1 1 Guanylylate cyclase Peptidase_C39_2 PF13529.1 KOO22210.1 - 5.5e-08 33.2 0.0 1.4e-07 31.9 0.0 1.7 1 1 0 1 1 1 1 Peptidase_C39 like family Transpep_BrtH PF14399.1 KOO22210.1 - 6.5e-06 25.6 0.0 1e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 NlpC/p60-like transpeptidase Peptidase_C39 PF03412.10 KOO22210.1 - 0.00035 20.3 0.0 0.077 12.8 0.0 2.3 2 0 0 2 2 2 2 Peptidase C39 family DUF3335 PF11814.3 KOO22210.1 - 0.054 12.6 0.2 5.3 6.1 0.0 2.6 3 0 0 3 3 3 0 Peptidase_C39 like family Amino_oxidase PF01593.19 KOO22211.1 - 3.9e-61 207.4 11.0 2.2e-59 201.7 7.6 2.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.1 KOO22211.1 - 4.7e-08 32.9 1.0 0.0034 17.1 0.1 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 KOO22211.1 - 5.6e-08 32.7 0.4 1.9e-07 31.0 0.2 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 KOO22211.1 - 3.5e-07 30.5 1.7 0.019 15.0 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 KOO22211.1 - 0.00048 19.2 0.1 0.0009 18.4 0.1 1.4 1 0 0 1 1 1 1 Thi4 family DAO PF01266.19 KOO22211.1 - 0.0012 17.8 6.2 0.025 13.4 4.3 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 KOO22211.1 - 0.0012 17.3 0.1 0.83 8.0 0.0 2.2 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.9 KOO22211.1 - 0.031 14.1 0.1 0.37 10.6 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOO22211.1 - 0.049 14.0 0.2 1.2 9.6 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AAA_34 PF13872.1 KOO22212.1 - 2.5e-104 348.3 0.0 4.3e-104 347.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.1 KOO22212.1 - 1.5e-94 316.5 0.1 5.6e-94 314.6 0.0 2.0 2 0 0 2 2 2 1 Helicase_C-like Helicase_C PF00271.26 KOO22212.1 - 1.8e-05 24.5 0.0 4.5e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Cytadhesin_P30 PF07271.6 KOO22212.1 - 0.11 11.7 0.3 0.23 10.6 0.2 1.5 1 0 0 1 1 1 0 Cytadhesin P30/P32 Metallophos PF00149.23 KOO22213.1 - 3.9e-11 42.7 0.0 9.4e-11 41.4 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase WD40 PF00400.27 KOO22214.1 - 6.4e-14 51.2 0.3 0.0072 16.1 0.1 5.7 6 0 0 6 6 6 3 WD domain, G-beta repeat Gmad1 PF10647.4 KOO22214.1 - 0.00013 21.4 1.9 0.41 9.9 0.0 2.9 1 1 2 3 3 3 3 Lipoprotein LpqB beta-propeller domain Cytochrom_D1 PF02239.11 KOO22214.1 - 0.00047 18.5 0.0 0.0091 14.3 0.0 2.1 2 0 0 2 2 2 1 Cytochrome D1 heme domain Aldo_ket_red PF00248.16 KOO22215.1 - 1.1e-29 103.1 0.0 1.5e-28 99.4 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family VWA_2 PF13519.1 KOO22216.1 - 3.9e-10 40.1 0.0 7.8e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT PF08487.5 KOO22216.1 - 0.023 14.3 0.0 0.041 13.5 0.0 1.4 1 0 0 1 1 1 0 Vault protein inter-alpha-trypsin domain VWA PF00092.23 KOO22216.1 - 0.045 13.4 0.0 0.086 12.5 0.0 1.4 1 1 0 1 1 1 0 von Willebrand factor type A domain Phage_integrase PF00589.17 KOO22218.1 - 0.047 13.3 0.0 0.09 12.4 0.0 1.4 1 0 0 1 1 1 0 Phage integrase family RCC1 PF00415.13 KOO22219.1 - 8.9e-64 211.5 11.1 1.2e-09 38.2 0.0 8.5 8 1 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO22219.1 - 2.2e-38 129.0 31.5 6.1e-08 32.0 0.0 8.2 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat CBM_X PF06204.6 KOO22219.1 - 0.071 12.6 2.3 33 4.0 0.0 3.9 3 0 0 3 3 3 0 Putative carbohydrate binding domain IBN_N PF03810.14 KOO22220.1 - 2e-12 46.8 1.7 1.6e-11 43.9 0.8 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT_2 PF13646.1 KOO22220.1 - 7.7e-07 29.3 17.2 0.013 15.8 0.4 7.3 6 1 2 8 8 8 2 HEAT repeats HEAT PF02985.17 KOO22220.1 - 0.022 14.8 23.9 1.2 9.3 0.0 10.7 13 0 0 13 13 13 0 HEAT repeat HEAT_EZ PF13513.1 KOO22220.1 - 0.022 15.2 24.1 0.93 10.0 0.0 8.6 10 2 2 12 12 12 0 HEAT-like repeat CheX PF13690.1 KOO22220.1 - 0.027 14.3 0.0 0.11 12.3 0.0 2.1 1 0 0 1 1 1 0 Chemotaxis phosphatase CheX CLASP_N PF12348.3 KOO22220.1 - 0.1 11.9 2.3 3.4 6.9 0.0 3.8 4 0 0 4 4 4 0 CLASP N terminal OTU PF02338.14 KOO22221.1 - 0.00044 20.8 0.2 0.0011 19.5 0.0 1.8 2 0 0 2 2 2 1 OTU-like cysteine protease ERCC4 PF02732.10 KOO22221.1 - 0.12 12.1 0.1 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 ERCC4 domain ApoLp-III PF07464.6 KOO22222.1 - 0.23 11.5 3.1 0.11 12.4 0.4 1.8 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) DIOX_N PF14226.1 KOO22223.1 - 1.2e-05 25.8 0.0 0.00014 22.3 0.0 2.3 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal Glyco_transf_90 PF05686.7 KOO22224.1 - 4e-27 94.9 0.0 1.5e-16 60.0 0.0 2.7 2 1 0 3 3 3 2 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.1 KOO22224.1 - 0.055 13.7 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 AP2 PF00847.15 KOO22228.1 - 4.6e-48 161.1 47.8 9.6e-05 22.4 0.5 15.8 13 3 1 14 14 14 12 AP2 domain zf-RING_2 PF13639.1 KOO22228.1 - 6.2e-09 35.5 5.9 1.2e-08 34.6 4.1 1.5 1 0 0 1 1 1 1 Ring finger domain IF3_N PF05198.11 KOO22228.1 - 3.9e-07 29.9 15.0 5.7 6.9 0.0 10.8 12 0 0 12 12 12 1 Translation initiation factor IF-3, N-terminal domain zf-rbx1 PF12678.2 KOO22228.1 - 0.00023 21.2 0.6 0.00048 20.1 0.4 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger FANCL_C PF11793.3 KOO22228.1 - 0.00051 19.9 3.8 0.0023 17.8 1.8 3.0 2 0 0 2 2 2 1 FANCL C-terminal domain zf-C3HC4_2 PF13923.1 KOO22228.1 - 0.0019 18.2 4.4 0.0088 16.0 3.1 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO22228.1 - 0.055 13.1 4.8 0.12 12.0 3.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO22228.1 - 0.14 11.9 5.6 0.26 11.0 3.9 1.5 1 0 0 1 1 1 0 zinc-RING finger domain RINGv PF12906.2 KOO22228.1 - 0.36 10.8 6.2 0.69 9.9 4.3 1.5 1 0 0 1 1 1 0 RING-variant domain Ank_2 PF12796.2 KOO22231.1 - 0.0013 19.0 0.1 0.0022 18.2 0.0 1.5 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO22231.1 - 0.004 16.9 0.0 0.016 15.0 0.0 2.1 1 1 0 1 1 1 1 Ankyrin repeat FlgN PF05130.7 KOO22231.1 - 0.011 15.9 0.0 0.016 15.4 0.0 1.2 1 0 0 1 1 1 0 FlgN protein AF0941-like PF14591.1 KOO22231.1 - 0.026 14.5 1.0 0.036 14.1 0.7 1.1 1 0 0 1 1 1 0 AF0941-like Stathmin PF00836.14 KOO22231.1 - 0.03 13.9 2.7 0.046 13.3 1.8 1.3 1 0 0 1 1 1 0 Stathmin family RmuC PF02646.11 KOO22231.1 - 0.034 12.9 0.2 0.04 12.7 0.1 1.1 1 0 0 1 1 1 0 RmuC family SQS_PSY PF00494.14 KOO22231.1 - 0.054 12.7 1.7 0.055 12.7 0.1 1.7 2 0 0 2 2 2 0 Squalene/phytoene synthase Foamy_virus_ENV PF03408.9 KOO22231.1 - 0.056 10.9 0.0 0.065 10.7 0.0 1.0 1 0 0 1 1 1 0 Foamy virus envelope protein IncA PF04156.9 KOO22231.1 - 0.063 12.8 6.3 1.2 8.6 0.2 2.1 2 0 0 2 2 2 0 IncA protein Vps53_N PF04100.7 KOO22231.1 - 0.079 11.7 0.9 0.092 11.5 0.6 1.0 1 0 0 1 1 1 0 Vps53-like, N-terminal Tektin PF03148.9 KOO22231.1 - 0.11 10.9 0.7 0.13 10.7 0.5 1.1 1 0 0 1 1 1 0 Tektin family DAP10 PF07213.6 KOO22231.1 - 0.12 12.1 0.4 0.19 11.4 0.2 1.3 1 0 0 1 1 1 0 DAP10 membrane protein DUF883 PF05957.8 KOO22231.1 - 0.14 12.6 6.2 0.42 11.0 4.3 1.9 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Ank_5 PF13857.1 KOO22231.1 - 0.17 12.1 0.5 2.3 8.6 0.0 2.7 2 1 1 3 3 3 0 Ankyrin repeats (many copies) IQ PF00612.22 KOO22232.1 - 0.00014 21.1 10.5 0.037 13.6 0.4 3.4 3 0 0 3 3 3 3 IQ calmodulin-binding motif TPMT PF05724.6 KOO22233.1 - 3.6e-37 127.9 0.0 8.2e-19 67.9 0.0 2.0 2 0 0 2 2 2 2 Thiopurine S-methyltransferase (TPMT) Methyltransf_18 PF12847.2 KOO22233.1 - 0.035 14.6 0.0 0.073 13.6 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 KOO22233.1 - 0.062 13.0 0.0 0.26 11.0 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain SelR PF01641.13 KOO22234.1 - 2.2e-44 150.1 0.1 2.7e-44 149.8 0.1 1.1 1 0 0 1 1 1 1 SelR domain DZR PF12773.2 KOO22234.1 - 0.02 14.7 0.9 0.094 12.5 0.6 2.1 1 1 0 1 1 1 0 Double zinc ribbon GFA PF04828.9 KOO22234.1 - 0.034 14.1 0.7 3.1 7.7 0.1 2.3 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme zf-Mss51 PF13824.1 KOO22234.1 - 0.037 13.8 1.4 0.43 10.4 0.2 2.8 2 1 1 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 Yippee-Mis18 PF03226.9 KOO22234.1 - 0.067 13.2 0.3 0.2 11.7 0.2 1.9 1 1 1 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Ribosomal_L37e PF01907.14 KOO22234.1 - 0.078 12.7 1.6 0.22 11.3 0.1 2.1 2 0 0 2 2 2 0 Ribosomal protein L37e TF_Zn_Ribbon PF08271.7 KOO22234.1 - 0.079 12.2 1.7 3.2 7.1 0.1 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding DUF2296 PF10058.4 KOO22234.1 - 0.082 12.6 0.9 3.7 7.3 0.0 2.3 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) zinc_ribbon_2 PF13240.1 KOO22234.1 - 0.1 12.1 1.6 2.6 7.6 0.4 2.6 2 0 0 2 2 2 0 zinc-ribbon domain RRN7 PF11781.3 KOO22234.1 - 0.11 12.0 1.9 4.2 6.9 0.3 2.4 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 zf-RanBP PF00641.13 KOO22235.1 - 1.8e-08 33.2 1.2 1.8e-08 33.2 0.9 1.9 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others ADH_N PF08240.7 KOO22235.1 - 0.11 12.2 0.3 0.2 11.4 0.2 1.4 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain GATA PF00320.22 KOO22235.1 - 0.12 11.7 3.0 3.5 7.0 0.1 2.4 2 0 0 2 2 2 0 GATA zinc finger Reo_sigmaC PF04582.7 KOO22235.1 - 0.15 11.2 0.3 0.22 10.6 0.2 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DZR PF12773.2 KOO22235.1 - 0.22 11.3 1.9 3.1 7.6 0.5 2.3 2 0 0 2 2 2 0 Double zinc ribbon DUF4094 PF13334.1 KOO22235.1 - 7.9 6.9 14.0 2.1 8.8 1.4 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4094) NHL PF01436.16 KOO22236.1 - 7.5e-24 82.4 0.0 3.7e-05 23.4 0.0 5.6 5 0 0 5 5 5 5 NHL repeat Arylesterase PF01731.15 KOO22236.1 - 2.8e-08 33.6 0.0 1.3 9.0 0.0 5.1 5 0 0 5 5 5 2 Arylesterase SGL PF08450.7 KOO22236.1 - 1.1e-07 31.5 0.2 0.23 10.8 0.0 4.3 1 1 0 3 3 3 2 SMP-30/Gluconolaconase/LRE-like region EF-hand_6 PF13405.1 KOO22236.1 - 5.2e-06 25.9 0.2 0.00055 19.6 0.0 2.8 2 0 0 2 2 2 1 EF-hand domain Lactonase PF10282.4 KOO22236.1 - 3.2e-05 23.1 1.2 0.25 10.3 0.0 2.8 1 1 1 2 2 2 2 Lactonase, 7-bladed beta-propeller EF-hand_1 PF00036.27 KOO22236.1 - 4.1e-05 22.5 0.0 0.00013 21.0 0.0 1.9 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO22236.1 - 8.6e-05 22.6 0.0 0.00018 21.5 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair Str_synth PF03088.11 KOO22236.1 - 0.00018 21.4 0.0 6.6 6.8 0.0 4.7 5 0 0 5 5 5 1 Strictosidine synthase EF-hand_8 PF13833.1 KOO22236.1 - 0.0012 18.3 0.0 0.0028 17.2 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair DUF839 PF05787.8 KOO22236.1 - 0.012 14.5 0.6 3 6.6 0.0 3.1 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF839) EF-hand_5 PF13202.1 KOO22236.1 - 0.036 13.4 0.0 0.096 12.0 0.0 1.7 1 0 0 1 1 1 0 EF hand PQQ_3 PF13570.1 KOO22236.1 - 0.055 13.7 8.0 0.66 10.3 0.2 4.9 5 1 1 6 6 5 0 PQQ-like domain DUF525 PF04379.9 KOO22236.1 - 0.068 13.1 0.0 0.73 9.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF525) PepSY_TM_2 PF13703.1 KOO22237.1 - 0.015 15.4 1.7 0.98 9.6 1.2 2.3 1 1 0 1 1 1 0 PepSY-associated TM helix Adeno_E3_CR2 PF02439.10 KOO22237.1 - 0.15 11.6 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Sir1 PF11603.3 KOO22238.1 - 0.0019 18.3 0.0 1.8 8.6 0.0 3.4 3 2 1 4 4 4 2 Regulatory protein Sir1 DUF2636 PF11120.3 KOO22238.1 - 0.0022 17.4 0.1 9.2 5.8 0.0 3.8 4 0 0 4 4 4 2 Protein of unknown function (DUF2636) Chisel PF15355.1 KOO22238.1 - 0.043 13.8 1.4 16 5.5 0.1 3.5 1 1 1 3 3 3 0 Stretch-responsive small skeletal muscle X protein, Chisel C2 PF00168.25 KOO22239.1 - 1.1e-52 175.8 0.0 1.8e-13 50.0 0.0 6.4 7 0 0 7 7 7 5 C2 domain NT-C2 PF10358.4 KOO22239.1 - 0.093 12.2 0.0 0.38 10.2 0.0 2.0 2 0 0 2 2 2 0 N-terminal C2 in EEIG1 and EHBP1 proteins DOCK-C2 PF14429.1 KOO22239.1 - 0.13 11.9 0.0 3 7.4 0.0 3.0 4 0 0 4 4 4 0 C2 domain in Dock180 and Zizimin proteins 2OG-FeII_Oxy_3 PF13640.1 KOO22240.1 - 3e-12 46.9 0.1 5.1e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO22240.1 - 0.00028 21.1 0.0 0.00048 20.3 0.0 1.4 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily LRR_5 PF13306.1 KOO22241.1 - 2.6e-100 331.1 7.5 1.9e-38 131.1 3.1 3.4 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO22241.1 - 5.2e-31 106.2 0.8 3.8e-05 23.3 0.1 7.3 1 1 7 8 8 8 8 Leucine rich repeat Pkinase PF00069.20 KOO22241.1 - 1.8e-30 105.9 0.0 1.9e-19 69.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Kelch_3 PF13415.1 KOO22241.1 - 2.5e-30 103.9 33.2 3.5e-07 30.2 0.1 9.5 9 1 0 9 9 9 6 Galactose oxidase, central domain Kelch_4 PF13418.1 KOO22241.1 - 7e-28 96.1 22.0 1.5e-06 27.8 0.0 8.2 7 0 0 7 7 7 7 Galactose oxidase, central domain Kelch_1 PF01344.20 KOO22241.1 - 4.4e-27 93.3 10.0 0.00088 18.7 0.0 8.6 8 0 0 8 8 8 7 Kelch motif Kelch_5 PF13854.1 KOO22241.1 - 6.6e-24 83.4 17.1 0.0056 16.6 0.0 8.7 8 0 0 8 8 8 6 Kelch motif Kelch_2 PF07646.10 KOO22241.1 - 6.9e-22 76.3 15.4 0.0029 17.3 0.0 8.2 8 0 0 8 8 8 7 Kelch motif Kelch_6 PF13964.1 KOO22241.1 - 1.1e-19 69.7 14.5 0.00047 20.2 0.0 8.6 7 1 1 8 8 8 5 Kelch motif Nol1_Nop2_Fmu PF01189.12 KOO22241.1 - 1.6e-14 53.9 0.0 6.1e-14 52.0 0.0 1.8 2 0 0 2 2 2 1 NOL1/NOP2/sun family SAM_1 PF00536.25 KOO22241.1 - 4.1e-11 42.8 0.1 1e-10 41.6 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 KOO22241.1 - 7.4e-09 35.3 0.1 1.7e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pkinase_Tyr PF07714.12 KOO22241.1 - 1.5e-07 30.7 0.0 0.0031 16.6 0.0 2.4 3 0 0 3 3 3 2 Protein tyrosine kinase Methyltransf_26 PF13659.1 KOO22241.1 - 0.0087 16.0 0.0 0.12 12.3 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain IPT PF01745.11 KOO22241.1 - 0.48 9.5 0.0 0.88 8.6 0.0 1.3 1 0 0 1 1 1 0 Isopentenyl transferase NOA36 PF06524.7 KOO22241.1 - 2.9 7.0 1.6 4.7 6.3 1.1 1.2 1 0 0 1 1 1 0 NOA36 protein MSP1_C PF07462.6 KOO22241.1 - 2.9 6.1 3.5 4.4 5.5 2.5 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Atg8 PF02991.11 KOO22243.1 - 4e-74 245.2 0.0 2.5e-37 126.9 0.0 2.3 2 1 0 2 2 2 2 Autophagy protein Atg8 ubiquitin like APG12 PF04110.8 KOO22243.1 - 1.8e-09 37.6 0.0 0.0019 18.3 0.0 2.4 2 1 0 2 2 2 2 Ubiquitin-like autophagy protein Apg12 Metallophos_2 PF12850.2 KOO22244.1 - 6.4e-08 32.5 0.1 2e-06 27.6 0.1 2.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 KOO22244.1 - 1.4e-06 27.8 1.1 5.1e-06 26.0 0.7 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase ECH PF00378.15 KOO22245.1 - 5.4e-42 143.6 2.9 1.2e-34 119.5 0.0 4.0 4 0 0 4 4 4 3 Enoyl-CoA hydratase/isomerase family ABC_tran PF00005.22 KOO22245.1 - 9.2e-42 142.5 0.0 1.5e-20 73.8 0.0 2.7 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 KOO22245.1 - 1.9e-21 77.3 0.0 8.7e-07 29.1 0.0 4.1 4 0 0 4 4 4 4 AAA domain Chal_sti_synt_N PF00195.14 KOO22245.1 - 2.2e-15 56.5 0.9 1.7e-14 53.6 0.3 2.3 2 0 0 2 2 2 1 Chalcone and stilbene synthases, N-terminal domain FAE1_CUT1_RppA PF08392.7 KOO22245.1 - 3.5e-13 49.2 0.0 8.2e-13 48.0 0.0 1.5 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein ABC_tran_2 PF12848.2 KOO22245.1 - 3.7e-13 49.1 6.1 7.1e-13 48.2 4.3 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 KOO22245.1 - 1.1e-11 44.4 0.0 0.12 11.5 0.0 4.4 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain Chal_sti_synt_C PF02797.10 KOO22245.1 - 2.1e-11 43.9 0.0 4.5e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain ACP_syn_III_C PF08541.5 KOO22245.1 - 7.7e-10 38.6 0.3 3.3e-09 36.6 0.0 2.3 2 0 0 2 2 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal AAA_29 PF13555.1 KOO22245.1 - 7.9e-08 31.7 0.2 0.014 14.9 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.1 KOO22245.1 - 7.8e-07 28.4 0.0 0.39 9.7 0.0 4.0 4 0 0 4 4 4 1 AAA ATPase domain NACHT PF05729.7 KOO22245.1 - 1.2e-06 28.2 0.0 0.0047 16.5 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_17 PF13207.1 KOO22245.1 - 6.2e-06 27.0 0.1 0.11 13.3 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.1 KOO22245.1 - 9.1e-06 26.1 4.6 0.022 15.0 0.1 2.6 3 0 0 3 3 2 2 AAA domain AAA_30 PF13604.1 KOO22245.1 - 9.2e-06 25.3 0.6 0.0036 16.8 0.0 2.9 3 0 0 3 3 2 1 AAA domain AAA_18 PF13238.1 KOO22245.1 - 5.2e-05 23.5 0.5 0.14 12.4 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.1 KOO22245.1 - 0.00012 22.1 0.1 0.25 11.2 0.0 3.3 2 0 0 2 2 2 1 AAA ATPase domain DUF258 PF03193.11 KOO22245.1 - 0.00014 21.1 0.0 0.11 11.7 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA PF00004.24 KOO22245.1 - 0.00017 21.7 0.1 0.78 9.9 0.0 3.1 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.1 KOO22245.1 - 0.00019 21.2 0.0 0.032 14.1 0.0 3.1 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_28 PF13521.1 KOO22245.1 - 0.0002 21.3 0.2 0.092 12.6 0.1 2.8 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 KOO22245.1 - 0.0015 18.4 0.0 2.8 7.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain DAP3 PF10236.4 KOO22245.1 - 0.0031 16.4 0.1 0.57 9.0 0.0 2.2 2 0 0 2 2 2 1 Mitochondrial ribosomal death-associated protein 3 FtsK_SpoIIIE PF01580.13 KOO22245.1 - 0.0037 16.7 3.0 0.038 13.4 0.0 2.8 3 0 0 3 3 3 1 FtsK/SpoIIIE family AAA_22 PF13401.1 KOO22245.1 - 0.0045 17.1 1.3 6.2 6.9 0.0 3.5 4 0 0 4 4 2 0 AAA domain MutS_V PF00488.16 KOO22245.1 - 0.005 16.2 0.0 1.3 8.3 0.0 2.4 2 0 0 2 2 2 1 MutS domain V AAA_33 PF13671.1 KOO22245.1 - 0.0056 16.5 0.5 4.2 7.2 0.0 3.0 3 0 0 3 3 2 0 AAA domain T2SE PF00437.15 KOO22245.1 - 0.0065 15.4 0.2 0.2 10.4 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein RNA_helicase PF00910.17 KOO22245.1 - 0.0073 16.4 0.0 5 7.3 0.0 2.4 2 0 0 2 2 2 0 RNA helicase MMR_HSR1 PF01926.18 KOO22245.1 - 0.0081 16.1 0.2 6 6.8 0.0 2.8 2 1 0 2 2 2 0 50S ribosome-binding GTPase DUF815 PF05673.8 KOO22245.1 - 0.0094 14.9 0.1 4.1 6.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_25 PF13481.1 KOO22245.1 - 0.016 14.6 2.3 4 6.7 0.0 3.5 3 1 0 3 3 3 0 AAA domain SRP54 PF00448.17 KOO22245.1 - 0.017 14.5 0.9 0.3 10.5 0.2 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Miro PF08477.8 KOO22245.1 - 0.027 14.9 0.0 6.8 7.2 0.0 2.7 2 0 0 2 2 2 0 Miro-like protein MobB PF03205.9 KOO22245.1 - 0.047 13.3 0.0 4.2 7.0 0.0 3.4 4 0 0 4 4 3 0 Molybdopterin guanine dinucleotide synthesis protein B Arch_ATPase PF01637.13 KOO22245.1 - 0.052 13.2 0.3 5.1 6.7 0.0 3.0 3 0 0 3 3 3 0 Archaeal ATPase DUF2791 PF10923.3 KOO22245.1 - 0.052 12.1 0.1 0.093 11.3 0.0 1.3 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) Zeta_toxin PF06414.7 KOO22245.1 - 0.067 12.2 0.1 4.7 6.2 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin NTPase_1 PF03266.10 KOO22245.1 - 0.072 12.7 0.1 13 5.4 0.0 2.7 2 0 0 2 2 2 0 NTPase AAA_5 PF07728.9 KOO22245.1 - 0.077 12.7 0.2 12 5.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_13 PF13166.1 KOO22245.1 - 0.093 11.1 2.0 2.9 6.2 0.0 2.5 3 0 0 3 3 2 0 AAA domain Rad17 PF03215.10 KOO22245.1 - 0.1 11.2 0.3 1.7 7.2 0.1 2.3 2 1 1 3 3 3 0 Rad17 cell cycle checkpoint protein Arf PF00025.16 KOO22245.1 - 0.11 11.7 0.0 0.3 10.2 0.0 1.8 1 0 0 1 1 1 0 ADP-ribosylation factor family Viral_helicase1 PF01443.13 KOO22245.1 - 0.12 11.8 0.0 1.9 7.9 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase cobW PF02492.14 KOO22245.1 - 0.15 11.5 0.1 26 4.1 0.0 2.9 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain G-alpha PF00503.15 KOO22245.1 - 0.38 9.4 0.4 7.3 5.1 0.1 2.2 2 0 0 2 2 2 0 G-protein alpha subunit ABC_ATPase PF09818.4 KOO22245.1 - 0.72 8.3 4.1 7 5.1 0.0 3.0 3 0 0 3 3 3 0 Predicted ATPase of the ABC class Adeno_IVa2 PF02456.10 KOO22245.1 - 1 7.9 0.0 7.2 5.1 0.0 2.1 2 0 0 2 2 2 0 Adenovirus IVa2 protein Actin PF00022.14 KOO22248.1 - 8e-117 389.9 0.0 9.1e-117 389.8 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 KOO22248.1 - 1.2e-05 24.1 0.1 0.00057 18.5 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FTCD_C PF04961.7 KOO22248.1 - 4.4 6.6 5.8 9.8 5.5 2.4 2.1 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase RabGAP-TBC PF00566.13 KOO22249.1 - 7.6e-39 133.3 0.0 1e-38 132.9 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF830 PF05708.7 KOO22250.1 - 3e-07 30.5 0.0 2e-06 27.8 0.0 2.2 1 1 0 1 1 1 1 Orthopoxvirus protein of unknown function (DUF830) TIM PF00121.13 KOO22251.1 - 1.6e-64 217.3 0.0 1.8e-64 217.1 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase DUF1719 PF08224.6 KOO22251.1 - 0.045 12.8 0.0 0.063 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1719) DUF4102 PF13356.1 KOO22251.1 - 0.085 12.7 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4102) Pkinase PF00069.20 KOO22253.1 - 1.7e-33 115.8 0.0 1.9e-30 105.9 0.0 2.4 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22253.1 - 1.1e-15 57.4 0.0 2.1e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO22253.1 - 0.0032 16.5 2.5 0.023 13.7 1.7 2.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3953 PF13129.1 KOO22254.1 - 0.12 12.0 0.8 0.35 10.5 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3953) Na_Ca_ex PF01699.19 KOO22255.1 - 1.5e-33 115.3 32.5 2e-18 66.3 8.8 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Amino_oxidase PF01593.19 KOO22256.1 - 1.3e-13 50.8 2.6 2.5e-08 33.4 0.2 3.0 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 KOO22256.1 - 5.3e-12 45.5 1.7 6.3e-12 45.3 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOO22256.1 - 3.4e-08 32.7 3.3 0.0015 17.5 0.3 2.3 2 1 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 KOO22256.1 - 6.8e-06 25.1 0.3 0.0095 14.8 0.1 2.4 2 0 0 2 2 2 2 FAD binding domain GDI PF00996.13 KOO22256.1 - 0.067 11.5 0.0 0.16 10.2 0.0 1.5 2 0 0 2 2 2 0 GDP dissociation inhibitor Thi4 PF01946.12 KOO22256.1 - 0.14 11.2 0.1 0.5 9.4 0.0 1.8 2 0 0 2 2 2 0 Thi4 family LRR_6 PF13516.1 KOO22257.1 - 7.1e-07 28.6 0.0 1.4 9.1 0.0 6.5 6 0 0 6 6 6 1 Leucine Rich repeat NACHT PF05729.7 KOO22257.1 - 0.00038 20.1 0.1 0.00071 19.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_19 PF13245.1 KOO22257.1 - 0.0017 18.0 0.7 0.0069 16.1 0.1 2.4 2 0 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 KOO22257.1 - 0.079 13.0 0.0 0.27 11.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.20 KOO22258.1 - 4.6e-39 134.1 0.0 7.2e-39 133.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22258.1 - 1.5e-13 50.3 0.0 2.9e-13 49.4 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.1 KOO22258.1 - 0.0014 18.6 1.8 0.003 17.6 0.5 2.2 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO22258.1 - 0.0063 15.7 1.2 1.9 7.9 1.2 2.7 2 0 0 2 2 2 1 EF hand GAS PF13851.1 KOO22258.1 - 0.18 10.9 10.3 0.3 10.2 7.1 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding APG6 PF04111.7 KOO22258.1 - 3.3 6.6 9.3 5.1 6.0 6.5 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Arm PF00514.18 KOO22260.1 - 1.5e-08 34.1 7.5 0.0057 16.4 0.1 4.6 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 KOO22260.1 - 0.0014 17.8 0.5 0.016 14.3 0.0 2.6 4 0 0 4 4 4 1 Armadillo-like HEAT_2 PF13646.1 KOO22260.1 - 0.002 18.3 13.8 0.87 9.9 0.5 4.3 2 1 1 4 4 4 2 HEAT repeats HEAT PF02985.17 KOO22260.1 - 0.05 13.7 9.2 3.7 7.8 0.1 4.6 5 0 0 5 5 5 0 HEAT repeat DUF92 PF01940.11 KOO22261.1 - 1e-64 217.7 7.4 1e-64 217.7 5.1 1.4 2 0 0 2 2 2 1 Integral membrane protein DUF92 Tetraspannin PF00335.15 KOO22261.1 - 2.5 7.3 7.0 0.43 9.8 0.5 2.2 2 0 0 2 2 2 0 Tetraspanin family Prefoldin PF02996.12 KOO22262.1 - 8e-24 83.5 0.7 1.2e-23 82.9 0.5 1.3 1 0 0 1 1 1 1 Prefoldin subunit DUF4533 PF15047.1 KOO22262.1 - 0.016 14.6 1.5 0.026 13.9 0.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4533) LRR_6 PF13516.1 KOO22263.1 - 8.9e-26 87.0 5.7 0.00017 21.3 0.0 7.5 6 1 0 6 6 6 5 Leucine Rich repeat LRR_4 PF12799.2 KOO22263.1 - 0.0005 19.6 0.8 0.93 9.1 0.0 3.8 3 2 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO22263.1 - 0.0043 16.7 0.2 9.9 6.0 0.0 4.0 3 1 2 5 5 5 2 Leucine rich repeat LRR_7 PF13504.1 KOO22263.1 - 0.0047 16.9 0.2 19 6.0 0.0 4.8 5 0 0 5 5 5 1 Leucine rich repeat LRR_1 PF00560.28 KOO22263.1 - 0.0062 16.4 0.0 6.8 7.1 0.0 4.7 6 0 0 6 6 6 1 Leucine Rich Repeat CbiG_N PF11760.3 KOO22263.1 - 0.56 9.9 8.3 15 5.3 0.0 4.7 4 1 1 5 5 5 0 Cobalamin synthesis G N-terminal zf-C3HC4_2 PF13923.1 KOO22264.1 - 2.6e-09 36.9 10.0 4.3e-09 36.2 7.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO22264.1 - 1.5e-08 34.1 8.9 2.3e-08 33.5 6.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO22264.1 - 1.8e-08 33.9 13.0 2.5e-08 33.4 9.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO22264.1 - 4.5e-08 32.7 12.5 7.1e-08 32.1 8.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 KOO22264.1 - 1.7e-06 27.6 12.0 2.8e-06 26.9 8.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 KOO22264.1 - 4.4e-05 23.2 10.2 7e-05 22.6 7.1 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 KOO22264.1 - 0.00032 20.3 7.7 0.0013 18.3 2.6 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-Apc11 PF12861.2 KOO22264.1 - 0.00055 19.7 2.3 0.0008 19.2 1.6 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.1 KOO22264.1 - 0.0016 18.1 6.6 0.003 17.3 4.6 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein SNF2_N PF00176.18 KOO22264.1 - 0.039 12.7 0.0 0.057 12.2 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain zf-rbx1 PF12678.2 KOO22264.1 - 0.11 12.5 6.9 0.26 11.4 4.7 1.6 1 1 0 1 1 1 0 RING-H2 zinc finger Coronavirus_5 PF05528.6 KOO22264.1 - 0.12 12.2 1.0 0.22 11.3 0.7 1.4 1 0 0 1 1 1 0 Coronavirus gene 5 protein zf-RING_4 PF14570.1 KOO22264.1 - 0.32 10.5 10.2 0.57 9.8 7.1 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Nse PF11789.3 KOO22264.1 - 0.47 10.0 5.4 0.8 9.2 3.7 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.1 KOO22264.1 - 1.8 8.1 11.4 4.4 6.9 7.9 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 DUF1644 PF07800.7 KOO22264.1 - 2.1 8.2 9.6 6.3 6.6 3.4 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1644) Lycopene_cycl PF05834.7 KOO22265.1 - 2.7e-63 214.1 0.0 4.2e-63 213.5 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.9 KOO22265.1 - 2.6e-06 27.4 0.0 6.3e-06 26.1 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 KOO22265.1 - 2.6e-06 26.5 0.0 0.00047 19.1 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 KOO22265.1 - 3.6e-05 23.6 0.1 0.00025 20.9 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 KOO22265.1 - 4.1e-05 22.8 0.1 0.012 14.6 0.0 2.2 2 0 0 2 2 2 2 Thi4 family FAD_oxidored PF12831.2 KOO22265.1 - 0.00012 21.3 0.7 0.0012 18.0 0.5 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.9 KOO22265.1 - 0.00021 20.0 0.0 0.032 12.8 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase HI0933_like PF03486.9 KOO22265.1 - 0.00033 19.2 0.0 0.00048 18.7 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.19 KOO22265.1 - 0.00092 18.1 0.1 0.0065 15.3 0.0 2.3 3 0 0 3 3 3 1 FAD binding domain GIDA PF01134.17 KOO22265.1 - 0.0025 16.7 0.0 0.0036 16.2 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_3 PF01494.14 KOO22265.1 - 0.0051 15.9 0.0 0.0096 15.0 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain 3HCDH_N PF02737.13 KOO22265.1 - 0.0071 16.0 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.22 KOO22265.1 - 0.0084 16.4 0.0 0.044 14.1 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.18 KOO22265.1 - 0.031 14.0 0.0 0.058 13.1 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus TrkA_N PF02254.13 KOO22265.1 - 0.069 13.1 0.0 0.25 11.3 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_9 PF13454.1 KOO22265.1 - 0.13 11.9 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding E1_dh PF00676.15 KOO22268.1 - 9.6e-77 257.6 0.0 1.2e-76 257.3 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.16 KOO22268.1 - 0.00056 19.5 0.0 0.0024 17.4 0.0 2.0 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Mto2_bdg PF12808.2 KOO22268.1 - 0.015 15.3 3.5 0.027 14.5 2.4 1.4 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region tRNA-synt_2b PF00587.20 KOO22269.1 - 5.2e-39 133.5 0.0 8.6e-39 132.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 KOO22269.1 - 1.5e-11 44.1 0.0 3.9e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.9 KOO22269.1 - 7.3e-10 38.5 0.0 1.4e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Glyco_hydro_42 PF02449.10 KOO22269.1 - 0.002 17.3 0.0 0.0034 16.5 0.0 1.2 1 0 0 1 1 1 1 Beta-galactosidase CCER1 PF15482.1 KOO22269.1 - 0.014 15.0 0.7 0.032 13.8 0.5 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 Mito_fiss_reg PF05308.6 KOO22269.1 - 0.3 10.4 2.0 0.66 9.2 1.4 1.5 1 0 0 1 1 1 0 Mitochondrial fission regulator RNA_lig_T4_1 PF09511.5 KOO22271.1 - 1.1e-11 44.7 0.0 6.6e-09 35.5 0.0 2.2 2 0 0 2 2 2 2 RNA ligase Helicase_C PF00271.26 KOO22272.1 - 1.3e-09 37.7 0.0 2.1e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF3701 PF12482.3 KOO22272.1 - 0.077 12.7 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 Phage integrase protein DER1 PF04511.10 KOO22273.1 - 1.6e-27 96.2 5.8 2e-27 95.9 4.0 1.0 1 0 0 1 1 1 1 Der1-like family DUF3092 PF11289.3 KOO22273.1 - 0.03 13.5 2.7 0.046 12.9 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3092) RFamide_26RFa PF11109.3 KOO22274.1 - 0.0027 17.5 0.1 0.0042 16.9 0.0 1.2 1 0 0 1 1 1 1 Orexigenic neuropeptide Qrfp/P518 DUF3119 PF11317.3 KOO22275.1 - 3.3e-16 59.3 0.1 1.9e-15 56.9 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3119) Mito_carr PF00153.22 KOO22276.1 - 4.2e-60 199.4 1.9 2.2e-20 72.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Epimerase PF01370.16 KOO22277.1 - 3.1e-52 177.3 0.0 3.7e-52 177.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Epimerase_Csub PF13950.1 KOO22277.1 - 2.3e-26 91.5 0.2 4.1e-26 90.6 0.1 1.4 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit 3Beta_HSD PF01073.14 KOO22277.1 - 1.7e-14 53.1 0.0 2.9e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 KOO22277.1 - 2e-11 43.3 0.0 1.3e-10 40.7 0.0 2.1 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.1 KOO22277.1 - 6.2e-10 39.3 0.0 9.6e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding RmlD_sub_bind PF04321.12 KOO22277.1 - 6.3e-10 38.4 0.0 1.1e-09 37.5 0.0 1.4 2 0 0 2 2 2 1 RmlD substrate binding domain NAD_binding_4 PF07993.7 KOO22277.1 - 1.2e-08 34.1 0.0 5.6e-07 28.7 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.20 KOO22277.1 - 2.5e-08 34.0 0.0 5.4e-08 32.9 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOO22277.1 - 3e-05 23.7 0.1 0.00011 21.8 0.1 1.9 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.13 KOO22277.1 - 0.0017 18.0 0.1 0.0034 17.0 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NmrA PF05368.8 KOO22277.1 - 0.0022 17.3 0.1 0.0089 15.3 0.0 1.9 2 0 0 2 2 2 1 NmrA-like family UDPG_MGDP_dh_N PF03721.9 KOO22277.1 - 0.052 12.9 0.0 0.078 12.3 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.10 KOO22277.1 - 0.1 12.4 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Ion_trans PF00520.26 KOO22278.1 - 1.5e-30 105.9 19.3 8.8e-17 61.0 3.6 3.1 2 1 0 2 2 2 2 Ion transport protein Ion_trans_2 PF07885.11 KOO22278.1 - 4.8e-22 77.4 10.1 3.1e-13 49.2 0.8 3.3 4 0 0 4 4 4 2 Ion channel cNMP_binding PF00027.24 KOO22278.1 - 1.4e-14 53.6 0.0 3.1e-14 52.5 0.0 1.7 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_N PF08412.5 KOO22278.1 - 9.1e-08 31.3 0.0 6.6e-07 28.5 0.0 2.5 2 0 0 2 2 2 1 Ion transport protein N-terminal OPA3 PF07047.7 KOO22279.1 - 4.5e-24 84.7 1.0 7.2e-24 84.0 0.1 1.7 1 1 1 2 2 2 1 Optic atrophy 3 protein (OPA3) DUF1631 PF07793.6 KOO22279.1 - 0.002 16.3 0.6 0.0026 16.0 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1631) RIC3 PF15361.1 KOO22279.1 - 0.072 13.3 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 DUF2681 PF10883.3 KOO22279.1 - 0.28 11.4 3.0 0.35 11.0 1.0 1.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2681) Macoilin PF09726.4 KOO22279.1 - 0.56 8.4 3.8 0.72 8.0 2.6 1.1 1 0 0 1 1 1 0 Transmembrane protein PFK PF00365.15 KOO22280.1 - 2.9e-08 33.0 0.0 7.2e-08 31.7 0.0 1.7 1 1 0 1 1 1 1 Phosphofructokinase DUF4259 PF14078.1 KOO22280.1 - 0.073 13.5 0.4 2 8.9 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4259) IncA PF04156.9 KOO22281.1 - 0.0015 18.1 2.7 0.0015 18.1 1.9 2.2 2 0 0 2 2 2 1 IncA protein LRR_6 PF13516.1 KOO22281.1 - 0.093 12.8 0.1 24 5.3 0.0 3.5 3 0 0 3 3 3 0 Leucine Rich repeat MFS_1 PF07690.11 KOO22284.1 - 0.00063 18.5 9.6 0.00063 18.5 6.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily LRR_5 PF13306.1 KOO22285.1 - 1.8e-137 451.3 0.0 2.3e-36 124.3 0.0 4.0 1 1 3 4 4 4 4 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO22285.1 - 1.7e-34 117.3 0.0 0.00015 21.4 0.0 8.4 2 1 7 9 9 9 6 Leucine rich repeat DUF2240 PF09999.4 KOO22285.1 - 0.014 14.8 0.0 1.1 8.6 0.0 3.4 4 0 0 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2240) Skp1 PF01466.14 KOO22285.1 - 0.057 13.4 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Skp1 family, dimerisation domain Fork_head_N PF08430.7 KOO22285.1 - 0.14 12.5 26.0 4.4e+02 1.2 7.8 4.5 1 1 1 2 2 2 0 Forkhead N-terminal region Pkinase PF00069.20 KOO22287.1 - 6.3e-35 120.5 0.0 8.9e-35 120.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22287.1 - 7.2e-28 97.3 0.0 1.1e-27 96.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO22287.1 - 0.00012 21.1 0.0 0.00019 20.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOO22287.1 - 0.052 12.5 0.0 0.088 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PAT1 PF09770.4 KOO22287.1 - 0.14 10.4 2.1 0.18 10.0 1.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MIT PF04212.13 KOO22287.1 - 0.17 11.7 0.8 0.35 10.7 0.6 1.5 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain GATase_5 PF13507.1 KOO22288.1 - 6e-98 326.8 0.0 9.3e-98 326.2 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.17 KOO22288.1 - 1.8e-20 73.4 0.5 2.9e-20 72.8 0.3 1.4 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain DUF3584 PF12128.3 KOO22289.1 - 0.073 10.4 9.0 0.12 9.6 6.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Atg14 PF10186.4 KOO22289.1 - 0.32 9.9 7.6 0.64 8.9 5.2 1.4 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Filament PF00038.16 KOO22289.1 - 0.57 9.5 12.0 0.19 11.1 6.1 1.8 2 0 0 2 2 2 0 Intermediate filament protein Lectin_legB PF00139.14 KOO22290.1 - 5.4e-13 48.8 0.0 1.7e-06 27.6 0.0 2.3 2 0 0 2 2 2 2 Legume lectin domain PLAT PF01477.18 KOO22290.1 - 0.012 15.9 0.1 3.8 7.9 0.0 2.5 2 0 0 2 2 2 0 PLAT/LH2 domain DUF972 PF06156.8 KOO22290.1 - 0.056 13.7 0.2 0.27 11.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF972) SLAIN PF15301.1 KOO22291.1 - 0.018 14.2 3.4 0.02 14.1 2.4 1.1 1 0 0 1 1 1 0 SLAIN motif-containing family DNA_pol_viral_N PF00242.12 KOO22291.1 - 0.38 9.7 6.3 0.52 9.2 4.4 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain EF-hand_1 PF00036.27 KOO22294.1 - 3.5e-12 44.6 0.0 3.1e-05 22.9 0.1 2.8 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO22294.1 - 9.4e-12 43.7 0.1 8.8e-05 22.0 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.1 KOO22294.1 - 1.1e-11 43.4 1.6 8.7e-06 24.8 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO22294.1 - 9e-11 41.7 0.0 4.6e-10 39.4 0.1 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO22294.1 - 5.5e-08 32.3 0.6 0.00089 18.8 0.2 2.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.2 KOO22294.1 - 0.00042 20.0 0.6 0.001 18.7 0.0 2.0 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO22294.1 - 0.056 13.4 0.0 0.056 13.4 0.0 4.4 2 2 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO22294.1 - 0.18 11.4 1.4 2.2 7.9 0.0 2.7 3 0 0 3 3 3 0 EF hand Shadoo PF14999.1 KOO22295.1 - 0.045 13.6 11.3 1.1 9.1 0.1 2.4 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective Acetyltransf_10 PF13673.1 KOO22295.1 - 0.14 12.3 0.1 0.31 11.1 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DUF4326 PF14216.1 KOO22296.1 - 0.0013 19.2 0.4 0.0039 17.7 0.3 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4326) Exo_endo_phos PF03372.18 KOO22296.1 - 0.026 14.4 0.0 0.053 13.4 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family GLF PF03275.8 KOO22298.1 - 3.1e-72 242.3 0.3 4.2e-72 241.9 0.2 1.2 1 0 0 1 1 1 1 UDP-galactopyranose mutase NAD_binding_8 PF13450.1 KOO22298.1 - 5e-16 58.4 0.2 8.9e-16 57.6 0.1 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 KOO22298.1 - 0.016 14.1 0.0 0.025 13.5 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_oxidored PF12831.2 KOO22298.1 - 0.019 14.0 0.0 0.24 10.4 0.0 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 KOO22298.1 - 0.086 12.8 0.0 0.18 11.8 0.0 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 KOO22298.1 - 0.11 11.3 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Thi4 PF01946.12 KOO22298.1 - 0.2 10.7 0.1 0.36 9.8 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Rad51 PF08423.6 KOO22299.1 - 7.1e-21 74.2 0.0 1.8e-13 50.0 0.0 2.1 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.1 KOO22299.1 - 2.6e-13 49.8 1.0 6.4e-13 48.5 0.7 1.5 1 1 0 1 1 1 1 AAA domain KaiC PF06745.8 KOO22299.1 - 9.8e-08 31.3 0.0 1.4e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 KaiC RecA PF00154.16 KOO22299.1 - 2.2e-06 26.9 0.1 4.2e-06 26.0 0.1 1.4 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_19 PF13245.1 KOO22299.1 - 0.00064 19.4 1.6 0.0018 17.9 1.1 1.9 1 1 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 KOO22299.1 - 0.0011 19.1 0.0 0.0032 17.6 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_10 PF12846.2 KOO22299.1 - 0.0038 16.7 0.0 0.0057 16.1 0.0 1.2 1 0 0 1 1 1 1 AAA-like domain PhoH PF02562.11 KOO22299.1 - 0.011 14.9 0.1 0.022 13.9 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein ATP_bind_1 PF03029.12 KOO22299.1 - 0.022 14.2 0.1 0.035 13.6 0.1 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_16 PF13191.1 KOO22299.1 - 0.026 14.4 0.1 0.041 13.8 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.24 KOO22299.1 - 0.04 14.1 0.1 0.072 13.2 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MFS_1 PF07690.11 KOO22299.1 - 0.048 12.3 20.1 0.068 11.8 13.9 1.3 1 0 0 1 1 1 0 Major Facilitator Superfamily AAA_33 PF13671.1 KOO22299.1 - 0.057 13.2 0.0 0.098 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 KOO22299.1 - 0.11 13.3 0.1 0.19 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 KOO22299.1 - 0.14 11.7 0.4 0.44 10.1 0.3 1.9 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 KOO22299.1 - 0.15 11.4 0.3 0.32 10.4 0.1 1.6 2 0 0 2 2 2 0 IstB-like ATP binding protein MobB PF03205.9 KOO22299.1 - 0.18 11.5 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Pkinase PF00069.20 KOO22300.1 - 2.4e-74 249.7 0.0 3.1e-74 249.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22300.1 - 1.7e-35 122.3 0.1 1.1e-34 119.7 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO22300.1 - 7.2e-07 28.4 0.0 6e-05 22.1 0.0 2.2 1 1 1 2 2 2 2 Kinase-like RIO1 PF01163.17 KOO22300.1 - 0.0033 16.8 0.1 0.0057 16.0 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 KOO22300.1 - 0.086 12.5 0.1 0.34 10.6 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 KOO22300.1 - 0.21 10.3 0.0 0.32 9.7 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 tRNA-synt_2c PF01411.14 KOO22301.1 - 1.2e-201 670.8 0.0 1.4e-201 670.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.9 KOO22301.1 - 1.1e-15 57.1 0.0 2.7e-15 55.9 0.0 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.14 KOO22301.1 - 5.4e-06 26.0 1.2 5.4e-06 26.0 0.8 2.7 3 0 0 3 3 3 1 DHHA1 domain Vps35 PF03635.12 KOO22302.1 - 4.9e-66 223.4 1.8 1.3e-47 162.4 0.8 3.0 1 1 1 3 3 3 3 Vacuolar protein sorting-associated protein 35 NMT_C PF02799.10 KOO22303.1 - 2.4e-56 190.1 0.2 3.5e-56 189.6 0.1 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.14 KOO22303.1 - 1.6e-39 135.0 1.4 2.6e-26 92.1 0.1 2.5 1 1 1 2 2 2 2 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain MCM PF00493.18 KOO22304.1 - 2.8e-128 427.4 0.1 3.4e-128 427.1 0.0 1.1 1 0 0 1 1 1 1 MCM2/3/5 family Mg_chelatase PF01078.16 KOO22304.1 - 2.2e-08 33.5 0.2 1.1e-06 27.9 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 KOO22304.1 - 0.012 15.2 0.0 0.026 14.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 KOO22304.1 - 0.013 14.9 0.1 0.054 12.9 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_5 PF07728.9 KOO22304.1 - 0.015 14.9 0.0 0.041 13.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Peptidase_M90 PF06167.7 KOO22305.1 - 0.24 10.7 0.7 1.8 7.8 0.5 2.0 1 1 0 1 1 1 0 Glucose-regulated metallo-peptidase M90 Baculo_PEP_C PF04513.7 KOO22307.1 - 1.5 8.6 12.2 7.5 6.3 0.6 3.0 1 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus FliD_C PF07195.7 KOO22307.1 - 7.2 5.8 16.2 1.2 8.3 1.9 3.0 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 C-terminus DUF2456 PF10445.4 KOO22308.1 - 0.0095 15.8 0.3 0.015 15.2 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2456) Cytochrome-c551 PF10643.4 KOO22308.1 - 0.045 13.0 0.3 5.4 6.2 0.2 2.0 2 0 0 2 2 2 0 Photosystem P840 reaction-centre cytochrome c-551 Syntaxin PF00804.20 KOO22308.1 - 0.078 13.1 1.9 0.081 13.0 0.3 1.7 2 0 0 2 2 2 0 Syntaxin DUF4398 PF14346.1 KOO22308.1 - 2 8.5 12.3 0.57 10.2 3.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) DALR_2 PF09190.6 KOO22308.1 - 4.2 7.7 7.7 0.75 10.0 2.0 2.0 2 0 0 2 2 2 0 DALR domain IQ PF00612.22 KOO22309.1 - 0.014 14.9 0.7 0.036 13.7 0.5 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif Ank_3 PF13606.1 KOO22309.1 - 0.22 11.8 1.7 32 5.1 0.1 4.2 4 1 0 4 4 4 0 Ankyrin repeat HhH-GPD PF00730.20 KOO22310.1 - 3.5e-18 65.8 0.0 9e-18 64.5 0.0 1.7 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 KOO22310.1 - 1.3e-05 24.6 0.0 3.6e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif CCDC50_N PF15295.1 KOO22310.1 - 0.25 11.2 3.7 45 3.9 0.1 3.1 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 50 N-terminus ADH_zinc_N PF00107.21 KOO22311.1 - 5.6e-19 67.9 1.4 1.2e-18 66.8 0.6 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOO22311.1 - 2.6e-16 59.3 1.3 9.5e-16 57.5 0.6 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain 2-Hacid_dh_C PF02826.14 KOO22311.1 - 0.0009 18.4 0.4 0.0015 17.7 0.3 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.16 KOO22311.1 - 0.023 14.2 0.6 0.023 14.2 0.4 1.8 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain CoA_binding PF02629.14 KOO22311.1 - 0.041 14.3 0.0 4.7 7.7 0.0 2.5 2 0 0 2 2 2 0 CoA binding domain Shikimate_DH PF01488.15 KOO22311.1 - 0.091 12.8 0.1 0.24 11.5 0.0 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Arm PF00514.18 KOO22312.1 - 6.6e-53 174.8 4.5 2.9e-13 49.1 0.0 5.6 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO22312.1 - 1.8e-20 73.0 0.1 2.8e-09 37.1 0.0 4.0 1 1 3 4 4 4 4 HEAT repeats HEAT_EZ PF13513.1 KOO22312.1 - 1.2e-15 57.4 0.8 1.8e-10 40.9 0.0 3.6 3 1 1 4 4 4 2 HEAT-like repeat IBB PF01749.15 KOO22312.1 - 5.2e-15 55.3 1.4 8.5e-15 54.6 0.9 1.3 1 0 0 1 1 1 1 Importin beta binding domain HEAT PF02985.17 KOO22312.1 - 2.2e-10 39.6 3.1 2.4e-06 27.1 0.0 5.0 5 1 0 5 5 5 1 HEAT repeat HEAT_PBS PF03130.11 KOO22312.1 - 0.00019 21.5 0.1 0.14 12.6 0.0 3.8 3 0 0 3 3 3 1 PBS lyase HEAT-like repeat V-ATPase_H_C PF11698.3 KOO22312.1 - 0.0018 18.1 0.0 0.13 12.1 0.0 2.3 2 0 0 2 2 2 1 V-ATPase subunit H Arm_2 PF04826.8 KOO22312.1 - 0.011 14.8 0.0 0.035 13.2 0.0 1.7 1 1 1 2 2 2 0 Armadillo-like RICTOR_V PF14668.1 KOO22312.1 - 0.079 12.8 0.2 8.9 6.3 0.0 2.9 2 1 2 4 4 4 0 Rapamycin-insensitive companion of mTOR, domain 5 Nuc_sug_transp PF04142.10 KOO22313.1 - 8.6e-51 172.3 3.9 1.2e-50 171.8 2.7 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.6 KOO22313.1 - 6.6e-05 21.9 8.0 0.00026 20.0 5.6 1.8 1 1 0 1 1 1 1 UAA transporter family TPT PF03151.11 KOO22313.1 - 0.00059 19.4 16.3 0.078 12.6 3.8 2.7 2 1 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.15 KOO22313.1 - 0.0015 18.5 4.4 0.0015 18.5 3.0 2.5 2 0 0 2 2 2 1 EamA-like transporter family EmrE PF13536.1 KOO22313.1 - 0.038 14.1 1.4 0.038 14.1 1.0 3.4 3 1 1 4 4 4 0 Multidrug resistance efflux transporter Pkinase PF00069.20 KOO22314.1 - 7.7e-48 162.9 0.0 9e-48 162.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22314.1 - 5.4e-28 97.7 0.0 6.3e-28 97.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO22314.1 - 3.1e-06 27.1 0.1 7.7e-06 25.8 0.1 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO22314.1 - 0.00019 20.4 0.0 0.00031 19.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOO22314.1 - 0.0012 17.9 0.0 0.0019 17.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Astro_capsid_p PF12226.3 KOO22314.1 - 0.17 11.1 0.0 0.27 10.4 0.0 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein RIO1 PF01163.17 KOO22314.1 - 0.17 11.2 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 RIO1 family LSM PF01423.17 KOO22315.1 - 1.8e-16 59.4 0.4 2.3e-16 59.0 0.3 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 KOO22315.1 - 0.0046 16.8 0.2 0.006 16.4 0.1 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain Gemin7 PF11095.3 KOO22315.1 - 0.034 13.8 0.1 0.048 13.3 0.0 1.3 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) Tail_tube PF10618.4 KOO22315.1 - 0.038 13.7 0.1 0.055 13.2 0.1 1.3 1 0 0 1 1 1 0 Phage tail tube protein BPL_C PF02237.12 KOO22315.1 - 0.042 13.5 0.7 0.071 12.7 0.2 1.6 2 0 0 2 2 2 0 Biotin protein ligase C terminal domain Na_H_antiport_2 PF13726.1 KOO22315.1 - 0.12 12.3 0.1 0.18 11.7 0.1 1.2 1 0 0 1 1 1 0 Na+-H+ antiporter family Glyco_hydro_30 PF02055.11 KOO22316.1 - 7.8e-86 288.2 0.1 4.5e-85 285.7 0.0 1.8 2 0 0 2 2 2 1 O-Glycosyl hydrolase family 30 Ricin_B_lectin PF00652.17 KOO22316.1 - 5.9e-08 32.7 0.0 1.3e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.1 KOO22316.1 - 0.0032 17.7 0.0 0.73 10.2 0.0 2.8 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like Ribosomal_60s PF00428.14 KOO22316.1 - 1.1 9.7 17.4 2.9 8.3 12.0 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein UvrD-helicase PF00580.16 KOO22317.1 - 1.2e-53 182.5 0.0 3.1e-53 181.1 0.0 1.7 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.1 KOO22317.1 - 1.2e-36 126.9 0.0 2.4e-20 73.2 0.0 2.4 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.1 KOO22317.1 - 3.9e-11 43.0 0.0 1e-10 41.6 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.1 KOO22317.1 - 1.2e-10 40.9 0.5 1.2e-10 40.9 0.3 2.7 2 0 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 KOO22317.1 - 0.012 15.7 0.1 5.3 7.1 0.0 3.1 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.1 KOO22317.1 - 0.19 11.2 0.0 0.47 9.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain DDT PF02791.12 KOO22318.1 - 5.1e-10 38.9 0.0 2.5e-09 36.7 0.1 1.9 2 0 0 2 2 2 1 DDT domain HMG_box PF00505.14 KOO22318.1 - 1.4e-05 25.2 3.3 2.3e-05 24.5 1.2 2.0 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO22318.1 - 0.0002 21.6 3.7 0.00046 20.5 0.9 2.4 2 0 0 2 2 2 1 HMG-box domain WHIM1 PF15612.1 KOO22318.1 - 0.06 13.3 0.4 0.13 12.2 0.3 1.5 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 EF-hand_1 PF00036.27 KOO22319.1 - 3.1e-26 88.6 2.7 1.8e-08 33.1 0.0 4.6 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 KOO22319.1 - 2.8e-20 70.3 0.7 9.2e-07 28.2 0.0 4.9 4 1 1 5 5 5 3 EF-hand domain EF-hand_7 PF13499.1 KOO22319.1 - 4.7e-19 68.2 2.0 3.3e-11 43.1 0.1 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO22319.1 - 1.2e-16 60.0 12.0 6.5e-06 25.6 0.2 4.9 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO22319.1 - 2.4e-16 58.2 0.9 5.1e-05 22.4 0.0 5.3 4 1 1 5 5 5 3 EF hand EF-hand_9 PF14658.1 KOO22319.1 - 2.3e-06 27.4 0.0 0.07 13.0 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 KOO22319.1 - 1e-05 25.1 1.6 1.3 8.7 0.1 3.2 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand LETM1 PF07766.8 KOO22319.1 - 0.066 12.2 0.3 0.1 11.6 0.2 1.3 1 1 0 1 1 1 0 LETM1-like protein EF-hand_10 PF14788.1 KOO22319.1 - 0.09 12.4 1.0 0.25 11.0 0.2 2.2 2 0 0 2 2 2 0 EF hand FKBP_C PF00254.23 KOO22320.1 - 1.4e-19 69.9 0.0 2.4e-19 69.1 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF4163 PF13739.1 KOO22320.1 - 0.22 12.3 2.7 3.3 8.5 1.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4163) RNase_H2-Ydr279 PF09468.5 KOO22320.1 - 9.1 5.3 7.2 12 4.9 5.0 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) TIG PF01833.19 KOO22321.1 - 7e-149 484.2 85.1 7e-09 35.5 1.3 31.5 31 1 0 31 31 31 24 IPT/TIG domain hemP PF10636.4 KOO22321.1 - 0.044 13.3 0.3 34 4.1 0.0 4.6 4 0 0 4 4 4 0 Hemin uptake protein hemP DUF2760 PF10816.3 KOO22321.1 - 2.9 7.3 0.0 6.3 6.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2760) RCC_reductase PF06405.6 KOO22321.1 - 3.5 6.4 0.0 8.9 5.1 0.0 1.6 1 0 0 1 1 1 0 Red chlorophyll catabolite reductase (RCC reductase) NQRA PF05896.6 KOO22321.1 - 8.2 5.5 0.0 14 4.7 0.0 1.3 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) La PF05383.12 KOO22321.1 - 8.8 6.2 0.0 20 5.0 0.0 1.5 1 0 0 1 1 1 0 La domain Pkinase PF00069.20 KOO22322.1 - 9.2e-42 142.9 0.0 1.6e-41 142.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22322.1 - 5.8e-37 127.1 0.0 3.4e-36 124.6 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase DUF4448 PF14610.1 KOO22322.1 - 0.0012 18.4 0.2 0.0026 17.2 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF4381 PF14316.1 KOO22322.1 - 0.012 15.6 1.1 0.98 9.5 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) Herpes_gE PF02480.11 KOO22322.1 - 0.061 11.5 0.4 0.1 10.8 0.3 1.4 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Methyltransf_5 PF01795.14 KOO22323.1 - 5.8e-86 288.5 0.0 7.1e-46 156.8 0.0 2.0 2 0 0 2 2 2 2 MraW methylase family Methyltransf_18 PF12847.2 KOO22323.1 - 0.00035 21.1 0.1 0.098 13.2 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO22323.1 - 0.00069 19.6 7.7 0.018 15.0 4.9 2.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO22323.1 - 0.00076 19.0 0.0 0.16 11.5 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.7 KOO22323.1 - 0.00083 19.7 0.1 0.39 11.2 0.0 2.6 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.1 KOO22323.1 - 0.038 13.6 0.0 6.8 6.3 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain ADH_zinc_N PF00107.21 KOO22323.1 - 0.083 12.4 0.4 2.8 7.5 0.0 2.7 3 0 0 3 3 3 0 Zinc-binding dehydrogenase Methyltransf_12 PF08242.7 KOO22323.1 - 0.087 13.3 0.1 5 7.6 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain WD40 PF00400.27 KOO22324.1 - 5.2e-31 105.3 0.1 4.5e-11 42.1 0.2 4.2 4 0 0 4 4 4 4 WD domain, G-beta repeat PQQ_3 PF13570.1 KOO22324.1 - 8.7e-05 22.6 1.2 0.0014 18.8 0.0 3.0 3 0 0 3 3 3 1 PQQ-like domain CPSF_A PF03178.10 KOO22324.1 - 0.0047 16.0 0.0 2.3 7.2 0.0 2.1 2 0 0 2 2 2 2 CPSF A subunit region Nup160 PF11715.3 KOO22324.1 - 0.0075 14.4 0.2 0.018 13.2 0.2 1.7 1 1 0 1 1 1 1 Nucleoporin Nup120/160 TruB_C PF09142.6 KOO22324.1 - 0.012 15.2 0.3 4.7 6.9 0.0 2.5 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal DUF3312 PF11768.3 KOO22324.1 - 0.024 12.8 0.1 0.033 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3312) Cytochrom_D1 PF02239.11 KOO22324.1 - 0.046 12.0 0.2 0.14 10.4 0.1 1.7 1 1 0 1 1 1 0 Cytochrome D1 heme domain CNH PF00780.17 KOO22324.1 - 0.12 11.8 0.0 0.28 10.5 0.0 1.6 2 0 0 2 2 2 0 CNH domain Methyltransf_22 PF13383.1 KOO22326.1 - 8.6e-05 22.1 0.0 0.00012 21.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Pkinase PF00069.20 KOO22328.1 - 2.6e-45 154.6 0.0 4.6e-45 153.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22328.1 - 1.1e-15 57.4 0.0 2.4e-15 56.3 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO22328.1 - 3.4e-08 32.7 0.0 0.0001 21.4 0.0 2.6 2 1 0 2 2 2 2 Kinase-like YrbL-PhoP_reg PF10707.4 KOO22328.1 - 0.00087 18.6 0.0 0.0021 17.4 0.0 1.6 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Choline_kinase PF01633.15 KOO22328.1 - 0.011 15.3 0.0 0.029 13.9 0.0 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pox_ser-thr_kin PF05445.6 KOO22328.1 - 0.26 10.0 0.0 0.38 9.4 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase VCBS PF13517.1 KOO22330.1 - 2.2e-64 213.6 61.7 3e-14 53.1 3.1 6.4 2 2 4 6 6 6 6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO22330.1 - 2.2e-42 141.7 65.4 3.5e-06 26.5 1.5 7.3 7 0 0 7 7 7 7 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO22330.1 - 4.5e-17 62.0 23.2 0.066 12.6 0.0 7.1 1 1 6 7 7 7 7 Insecticide toxin TcdB middle/N-terminal region DUF4384 PF14326.1 KOO22330.1 - 9.5e-07 28.5 0.1 4.5 7.1 0.0 6.2 1 1 6 7 7 7 1 Domain of unknown function (DUF4384) EF-hand_1 PF00036.27 KOO22330.1 - 0.034 13.4 31.6 17 5.0 0.2 7.2 7 0 0 7 7 7 0 EF hand Phage_AlpA PF05930.7 KOO22330.1 - 0.051 13.3 0.0 6.5 6.5 0.0 4.0 6 0 0 6 6 6 0 Prophage CP4-57 regulatory protein (AlpA) EF-hand_5 PF13202.1 KOO22330.1 - 0.053 12.8 45.9 6 6.3 0.6 7.3 7 0 0 7 7 7 0 EF hand Excalibur PF05901.6 KOO22330.1 - 2.4 8.5 13.0 2.9e+02 1.8 0.0 6.5 7 0 0 7 7 7 0 Excalibur calcium-binding domain FTCD_C PF04961.7 KOO22332.1 - 0.082 12.3 0.2 0.082 12.3 0.2 1.7 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase DUF1840 PF08895.6 KOO22332.1 - 1.4 8.9 6.2 0.43 10.6 0.8 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF1840) GDA1_CD39 PF01150.12 KOO22333.1 - 6.7e-57 192.9 0.0 1.7e-45 155.3 0.0 2.6 1 1 1 2 2 2 2 GDA1/CD39 (nucleoside phosphatase) family PMSR PF01625.16 KOO22334.1 - 4.4e-55 185.8 0.0 5.8e-55 185.4 0.0 1.1 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Metallophos PF00149.23 KOO22335.1 - 1.8e-14 53.6 0.0 3e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.1 KOO22335.1 - 2.9e-10 40.0 0.0 8.8e-10 38.5 0.0 1.9 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C PhoD PF09423.5 KOO22335.1 - 1.4e-05 23.8 0.1 2.5e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 PhoD-like phosphatase Metallophos_2 PF12850.2 KOO22335.1 - 0.00023 21.0 0.0 0.00054 19.8 0.0 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain TPR_12 PF13424.1 KOO22336.1 - 4.7e-31 106.5 7.3 9.1e-18 63.9 0.3 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.1 KOO22336.1 - 6.3e-27 92.6 8.2 4.3e-09 36.0 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO22336.1 - 2.2e-08 33.3 2.3 0.034 13.7 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO22336.1 - 2.4e-07 30.1 4.3 0.26 11.3 0.1 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_4 PF07721.9 KOO22336.1 - 9.1e-07 28.7 7.5 1.4 9.5 0.0 5.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO22336.1 - 1.7e-05 24.2 0.3 0.25 11.2 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO22336.1 - 4.4e-05 23.0 1.5 0.0019 17.7 0.2 2.7 1 1 1 2 2 2 2 TPR repeat TPR_17 PF13431.1 KOO22336.1 - 5e-05 23.1 1.9 3.5 8.0 0.0 4.3 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO22336.1 - 0.00014 21.3 9.1 0.0027 17.3 0.1 3.9 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO22336.1 - 0.00015 21.9 1.9 0.0031 17.8 0.3 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO22336.1 - 0.00064 20.3 13.6 0.0014 19.2 0.6 4.2 3 1 2 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO22336.1 - 0.0065 17.0 14.8 1.5 9.6 0.4 4.9 5 0 0 5 5 3 2 Tetratricopeptide repeat Osmo_CC PF08946.5 KOO22336.1 - 0.0082 16.1 1.6 3.6 7.6 0.0 3.8 4 0 0 4 4 4 1 Osmosensory transporter coiled coil Orexin PF02072.10 KOO22336.1 - 0.028 14.1 0.9 4 7.2 0.1 2.5 2 0 0 2 2 2 0 Prepro-orexin TPR_3 PF07720.7 KOO22336.1 - 0.03 14.1 0.1 7.1 6.5 0.0 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat ApoLp-III PF07464.6 KOO22336.1 - 0.1 12.6 0.0 17 5.3 0.0 2.4 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) HisKA_3 PF07730.8 KOO22336.1 - 0.28 11.5 3.0 12 6.2 0.5 3.3 2 0 0 2 2 2 0 Histidine kinase EF-hand_5 PF13202.1 KOO22337.1 - 6.5e-13 47.3 0.1 2.5e-06 26.5 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.27 KOO22337.1 - 6.5e-11 40.7 0.1 5e-05 22.3 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO22337.1 - 8.5e-11 40.7 0.6 3.8e-05 23.2 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO22337.1 - 4.6e-10 39.4 0.4 3.5e-08 33.4 0.1 3.0 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO22337.1 - 4.1e-07 29.5 0.4 0.027 14.0 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair RIIa PF02197.12 KOO22337.1 - 6.4e-06 25.4 0.2 1.4e-05 24.4 0.2 1.5 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit zf-C3HC4_3 PF13920.1 KOO22338.1 - 1.6e-07 30.8 5.5 3e-07 30.0 3.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO22338.1 - 0.00036 20.4 6.5 0.00083 19.3 4.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF2207 PF09972.4 KOO22338.1 - 0.54 8.7 3.0 0.8 8.2 2.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Histone PF00125.19 KOO22339.1 - 1.7e-14 53.6 0.2 2.1e-14 53.4 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 KOO22339.1 - 2.9e-05 24.1 0.1 3.9e-05 23.7 0.1 1.3 1 1 0 1 1 1 1 Kinetochore component CENP-S TAF PF02969.12 KOO22339.1 - 0.0002 21.2 0.2 0.00028 20.7 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.18 KOO22339.1 - 0.00049 20.0 0.1 0.0008 19.4 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 KOO22339.1 - 0.0061 16.2 0.0 0.0085 15.7 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.10 KOO22339.1 - 0.034 13.9 0.0 0.041 13.6 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit CENP-T PF15511.1 KOO22339.1 - 0.035 13.3 0.0 0.035 13.3 0.0 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Ank_5 PF13857.1 KOO22340.1 - 0.0022 18.1 0.7 0.29 11.4 0.0 3.1 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO22340.1 - 0.038 14.2 0.0 6.7 7.2 0.0 3.1 2 0 0 2 2 2 0 Ankyrin repeat zf-RING_2 PF13639.1 KOO22342.1 - 0.0076 16.0 0.5 0.015 15.1 0.3 1.5 1 0 0 1 1 1 1 Ring finger domain Mito_carr PF00153.22 KOO22343.1 - 6.3e-36 121.9 2.6 3.7e-20 71.4 0.1 2.4 3 0 0 3 3 3 2 Mitochondrial carrier protein O-ag_pol_Wzy PF14296.1 KOO22343.1 - 0.098 11.2 0.0 0.12 10.8 0.0 1.1 1 0 0 1 1 1 0 O-antigen polysaccharide polymerase Wzy TPR_11 PF13414.1 KOO22344.1 - 5.3e-08 32.4 0.3 0.0047 16.5 0.0 3.6 3 0 0 3 3 3 2 TPR repeat TPR_19 PF14559.1 KOO22344.1 - 0.0063 16.8 6.8 0.095 13.0 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO22344.1 - 0.0071 16.0 0.6 0.19 11.5 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOO22344.1 - 0.0072 16.2 0.5 0.029 14.3 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO22344.1 - 0.0098 15.7 0.0 0.0098 15.7 0.0 5.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO22344.1 - 0.011 15.2 0.1 0.25 11.0 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1446 PF07287.6 KOO22344.1 - 0.092 11.1 0.5 2.2 6.6 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1446) TPR_14 PF13428.1 KOO22344.1 - 0.097 13.3 0.1 0.097 13.3 0.1 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat zf-ZPR1 PF03367.8 KOO22345.1 - 0.0056 15.8 0.1 0.012 14.7 0.0 1.6 2 0 0 2 2 2 1 ZPR1 zinc-finger domain Rsc14 PF08586.5 KOO22346.1 - 0.064 13.7 0.1 13 6.3 0.0 3.4 2 1 2 4 4 4 0 RSC complex, Rsc14/Ldb7 subunit Auxin_inducible PF02519.9 KOO22346.1 - 0.17 11.9 25.7 1.2 9.2 1.2 4.2 1 1 3 4 4 4 0 Auxin responsive protein HlyD_3 PF13437.1 KOO22346.1 - 0.19 12.0 1.7 4.8 7.5 0.1 2.8 1 1 2 3 3 3 0 HlyD family secretion protein BPD_transp_1 PF00528.17 KOO22346.1 - 0.23 10.9 1.5 9.6 5.6 0.0 3.5 4 0 0 4 4 4 0 Binding-protein-dependent transport system inner membrane component RPE65 PF03055.10 KOO22347.1 - 1.4e-72 244.8 0.0 4.7e-72 243.1 0.0 1.7 1 1 0 1 1 1 1 Retinal pigment epithelial membrane protein SNF2_N PF00176.18 KOO22349.1 - 2.2e-65 220.4 0.0 3.2e-65 219.8 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF3578 PF12102.3 KOO22349.1 - 2e-30 105.8 0.0 3.7e-30 104.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3578) Chromo PF00385.19 KOO22349.1 - 5.1e-13 48.4 0.0 3.1e-07 29.9 0.0 3.9 4 0 0 4 4 3 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.26 KOO22349.1 - 8.1e-13 48.0 0.0 1.6e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.24 KOO22349.1 - 4e-09 36.0 5.0 8.6e-09 34.9 3.5 1.6 1 0 0 1 1 1 1 PHD-finger HDA2-3 PF11496.3 KOO22349.1 - 1.4e-05 24.0 0.5 3.1e-05 22.9 0.0 1.8 2 0 0 2 2 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.24 KOO22349.1 - 3.1e-05 23.5 0.0 0.00023 20.6 0.0 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 KOO22349.1 - 4.1e-05 23.5 1.6 0.051 13.4 0.0 3.1 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit AAA_22 PF13401.1 KOO22349.1 - 0.0096 16.0 0.0 0.089 12.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain zf-RING-like PF08746.6 KOO22349.1 - 0.077 13.0 0.6 0.18 11.8 0.4 1.6 1 0 0 1 1 1 0 RING-like domain zf-rbx1 PF12678.2 KOO22349.1 - 0.17 12.0 1.3 0.4 10.8 0.9 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger zf-RING_2 PF13639.1 KOO22349.1 - 2.9 7.8 6.0 8.6 6.2 4.1 1.9 1 0 0 1 1 1 0 Ring finger domain Nucleoside_tran PF01733.13 KOO22349.1 - 7.8 5.5 4.6 14 4.7 3.2 1.3 1 0 0 1 1 1 0 Nucleoside transporter His_Phos_1 PF00300.17 KOO22350.1 - 1.2e-14 54.7 1.3 4.4e-14 52.8 0.0 2.1 1 1 1 2 2 2 1 Histidine phosphatase superfamily (branch 1) DUF4336 PF14234.1 KOO22351.1 - 0.00065 18.9 0.0 0.0026 17.0 0.0 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF4336) PP2C PF00481.16 KOO22352.1 - 3.4e-34 118.3 0.0 5.7e-34 117.6 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C Methyltransf_16 PF10294.4 KOO22353.1 - 1.8e-17 63.3 0.0 3.6e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Neur_chan_memb PF02932.11 KOO22353.1 - 5.7e-07 29.6 1.5 5.7e-07 29.6 1.1 2.0 1 1 1 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region TehB PF03848.9 KOO22353.1 - 0.052 12.7 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Tellurite resistance protein TehB MTS PF05175.9 KOO22353.1 - 0.13 11.5 0.0 0.29 10.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain ALIX_LYPXL_bnd PF13949.1 KOO22353.1 - 0.27 10.1 1.8 0.4 9.5 1.2 1.2 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV ATP-synt_C PF00137.16 KOO22355.1 - 3.3e-23 81.3 22.7 2.6e-14 52.8 3.5 2.2 2 0 0 2 2 2 2 ATP synthase subunit C DUF4064 PF13273.1 KOO22355.1 - 1 9.4 9.0 0.17 11.9 1.3 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF4064) MFS_1 PF07690.11 KOO22357.1 - 3.9e-15 55.4 33.0 3.9e-15 55.4 22.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily IQ PF00612.22 KOO22358.1 - 0.075 12.7 0.8 0.19 11.4 0.6 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif Lactonase PF10282.4 KOO22359.1 - 2.4e-39 135.3 0.0 2.8e-37 128.5 0.0 2.9 2 1 0 2 2 2 2 Lactonase, 7-bladed beta-propeller SET PF00856.23 KOO22360.1 - 0.0012 19.1 0.0 0.81 9.9 0.0 2.2 2 0 0 2 2 2 2 SET domain Peptidase_S10 PF00450.17 KOO22361.1 - 5.1e-115 384.9 0.0 5.9e-115 384.7 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.2 KOO22361.1 - 9.1e-05 22.4 0.2 0.0011 18.9 0.1 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO22361.1 - 0.00055 19.7 0.0 0.0045 16.7 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family WD40 PF00400.27 KOO22363.1 - 4.9e-11 42.0 3.9 0.00015 21.5 0.4 3.6 2 1 0 2 2 2 2 WD domain, G-beta repeat DUF3326 PF11805.3 KOO22363.1 - 0.13 10.9 0.1 0.2 10.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3326) PQQ_3 PF13570.1 KOO22363.1 - 0.54 10.6 0.1 0.54 10.6 0.1 3.7 3 1 1 4 4 4 0 PQQ-like domain IFP_35_N PF07334.8 KOO22364.1 - 0.0022 17.9 0.1 7.2 6.6 0.0 3.5 4 0 0 4 4 4 2 Interferon-induced 35 kDa protein (IFP 35) N-terminus NUDIX PF00293.23 KOO22364.1 - 0.0025 17.4 0.1 2.7 7.6 0.0 2.3 2 0 0 2 2 2 2 NUDIX domain DUF1344 PF07076.6 KOO22364.1 - 0.016 14.7 0.0 4.8 6.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1344) Rnk_N PF14760.1 KOO22364.1 - 0.037 14.1 0.3 2.4 8.2 0.1 2.5 2 0 0 2 2 2 0 Rnk N-terminus Usg PF06233.7 KOO22364.1 - 0.039 13.7 0.0 15 5.5 0.0 2.5 2 0 0 2 2 2 0 Usg-like family TBP-binding PF09247.6 KOO22364.1 - 0.047 13.9 0.0 17 5.7 0.0 2.4 2 0 0 2 2 2 0 TATA box-binding protein binding Suc_Fer-like PF06999.7 KOO22364.1 - 0.12 12.3 0.1 1.1 9.2 0.0 2.4 3 1 1 4 4 4 0 Sucrase/ferredoxin-like Exonuc_VII_S PF02609.11 KOO22364.1 - 3.8 7.3 6.4 15 5.4 0.6 2.5 2 0 0 2 2 2 0 Exonuclease VII small subunit AIG1 PF04548.11 KOO22365.1 - 2e-20 72.8 0.0 2.6e-20 72.4 0.0 1.1 1 0 0 1 1 1 1 AIG1 family GBP PF02263.14 KOO22365.1 - 0.018 14.0 0.0 0.025 13.6 0.0 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.18 KOO22365.1 - 0.039 13.9 0.0 0.07 13.0 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF258 PF03193.11 KOO22365.1 - 0.049 12.8 0.0 0.09 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_16 PF13191.1 KOO22365.1 - 0.15 12.0 2.7 1.4 8.8 0.1 2.1 2 0 0 2 2 2 0 AAA ATPase domain 2OG-FeII_Oxy_3 PF13640.1 KOO22366.1 - 1.6e-11 44.5 0.1 3.4e-11 43.5 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO22366.1 - 1.7e-05 24.9 0.0 4.1e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ShK PF01549.19 KOO22366.1 - 7e-05 23.1 4.1 0.00022 21.5 2.8 1.9 1 0 0 1 1 1 1 ShK domain-like Pkinase PF00069.20 KOO22367.1 - 3.8e-61 206.5 0.0 7.6e-61 205.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.24 KOO22367.1 - 2.1e-33 113.9 0.2 2.7e-19 68.7 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.12 KOO22367.1 - 1.9e-25 89.4 0.0 2.8e-25 88.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO22367.1 - 1.4e-05 24.2 0.0 2.4e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 KOO22367.1 - 0.17 10.7 0.0 0.26 10.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 DUF2587 PF10759.4 KOO22367.1 - 6.1 6.2 11.0 0.31 10.4 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2587) PPR_2 PF13041.1 KOO22369.1 - 1.6e-06 28.0 0.0 0.0026 17.6 0.0 3.6 4 0 0 4 4 4 2 PPR repeat family PPR_3 PF13812.1 KOO22369.1 - 0.062 13.6 4.9 62 4.2 0.1 5.7 5 1 0 5 5 5 0 Pentatricopeptide repeat domain Saccharop_dh_N PF04455.7 KOO22369.1 - 0.38 10.9 2.0 12 6.1 0.1 3.3 4 0 0 4 4 4 0 LOR/SDH bifunctional enzyme conserved region RPE65 PF03055.10 KOO22370.1 - 8.7e-74 248.8 0.0 9.7e-74 248.6 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein DUF1546 PF07571.8 KOO22371.1 - 0.14 12.3 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1546) CheR PF01739.13 KOO22373.1 - 0.016 14.5 0.1 0.023 13.9 0.1 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Methyltransf_2 PF00891.13 KOO22373.1 - 0.064 12.4 0.0 0.082 12.0 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase HEAT_2 PF13646.1 KOO22375.1 - 0.00067 19.8 1.7 0.0032 17.7 0.4 2.6 2 1 0 2 2 2 1 HEAT repeats DUF1217 PF06748.7 KOO22375.1 - 0.0087 16.1 1.7 0.022 14.8 0.2 2.2 2 1 1 3 3 3 1 Protein of unknown function (DUF1217) LIP PF03583.9 KOO22375.1 - 0.0088 15.2 0.1 0.015 14.4 0.0 1.3 1 1 0 1 1 1 1 Secretory lipase XPC-binding PF09280.6 KOO22375.1 - 0.024 14.0 16.4 0.15 11.5 0.2 4.2 3 1 1 4 4 4 0 XPC-binding domain tRNA-synt_His PF13393.1 KOO22375.1 - 0.028 13.4 1.3 0.094 11.7 0.3 2.0 1 1 1 2 2 2 0 Histidyl-tRNA synthetase FANCI_S1-cap PF14674.1 KOO22375.1 - 0.081 12.9 3.7 11 6.1 0.0 4.2 3 2 0 3 3 3 0 FANCI solenoid 1 cap PEP-utilisers_N PF05524.8 KOO22375.1 - 1.4 8.6 6.0 18 5.1 0.2 3.3 2 1 2 4 4 4 0 PEP-utilising enzyme, N-terminal GED PF02212.13 KOO22375.1 - 5 7.0 9.5 15 5.5 0.3 3.2 2 1 1 3 3 3 0 Dynamin GTPase effector domain Aminotran_4 PF01063.14 KOO22376.1 - 8e-21 74.5 0.0 1.1e-20 74.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class IV SURF1 PF02104.10 KOO22377.1 - 4.1e-38 131.3 0.0 5.3e-38 130.9 0.0 1.1 1 0 0 1 1 1 1 SURF1 family LRR_6 PF13516.1 KOO22378.1 - 2.5e-13 48.6 7.0 0.00059 19.6 0.0 6.4 7 1 0 7 7 7 3 Leucine Rich repeat NACHT PF05729.7 KOO22378.1 - 1.8e-06 27.7 0.1 3.3e-06 26.8 0.1 1.4 1 0 0 1 1 1 1 NACHT domain LRR_4 PF12799.2 KOO22378.1 - 0.0038 16.8 10.4 10 5.8 0.1 5.5 2 2 1 4 4 4 1 Leucine Rich repeats (2 copies) AAA_22 PF13401.1 KOO22378.1 - 0.039 14.0 0.0 0.13 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain LRR_7 PF13504.1 KOO22378.1 - 0.16 12.2 6.8 1.1e+02 3.7 0.0 6.1 7 0 0 7 7 7 0 Leucine rich repeat DUF4244 PF14029.1 KOO22379.1 - 0.031 13.3 0.1 0.05 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4244) Flavodoxin_2 PF02525.12 KOO22380.1 - 2.8e-28 98.8 0.0 3.1e-28 98.6 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.10 KOO22380.1 - 3.2e-12 46.2 0.0 3.7e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase WW PF00397.21 KOO22381.1 - 2.4e-10 40.0 0.2 3.7e-10 39.4 0.1 1.3 1 0 0 1 1 1 1 WW domain PDZ_2 PF13180.1 KOO22381.1 - 0.063 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 PDZ domain GSHPx PF00255.14 KOO22382.1 - 9.6e-30 102.1 0.0 1.1e-29 101.9 0.0 1.0 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.16 KOO22382.1 - 0.0092 15.6 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Enolase_C PF00113.17 KOO22383.1 - 4e-156 518.4 0.2 6.6e-156 517.7 0.2 1.3 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.11 KOO22383.1 - 2.1e-55 186.2 0.3 4.7e-55 185.1 0.2 1.6 1 0 0 1 1 1 1 Enolase, N-terminal domain MAAL_C PF07476.6 KOO22383.1 - 3.4e-07 29.4 0.1 6.8e-07 28.4 0.0 1.5 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus MR_MLE_C PF13378.1 KOO22383.1 - 5.8e-06 26.2 0.0 1.6e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 Enolase C-terminal domain-like WD40 PF00400.27 KOO22384.1 - 8.3e-42 139.6 21.6 4.7e-09 35.7 0.1 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat PFU PF09070.6 KOO22384.1 - 1.3e-29 102.5 0.1 2.1e-29 101.8 0.1 1.3 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) PUL PF08324.6 KOO22384.1 - 4.9e-23 81.2 0.2 7.1e-23 80.7 0.2 1.2 1 0 0 1 1 1 1 PUL domain BBS2_Mid PF14783.1 KOO22384.1 - 8.6e-05 22.2 0.0 0.25 11.1 0.0 3.4 3 0 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region Dimerisation PF08100.6 KOO22384.1 - 0.45 10.3 5.2 3.2 7.6 0.3 3.6 3 0 0 3 3 3 0 Dimerisation domain YebO PF13974.1 KOO22385.1 - 0.72 9.6 7.3 0.13 12.0 0.7 2.7 2 1 0 2 2 2 0 YebO-like protein HTH_37 PF13744.1 KOO22385.1 - 5.1 6.9 11.0 0.37 10.6 0.3 3.2 3 0 0 3 3 3 0 Helix-turn-helix domain TIG PF01833.19 KOO22386.1 - 5.6e-169 548.6 35.7 1.4e-08 34.6 0.0 35.2 33 4 0 33 33 33 27 IPT/TIG domain PAN_1 PF00024.21 KOO22386.1 - 0.015 15.0 4.4 0.038 13.7 3.1 1.6 1 0 0 1 1 1 0 PAN domain PAN_4 PF14295.1 KOO22386.1 - 0.23 11.2 3.6 0.72 9.6 2.5 1.8 1 0 0 1 1 1 0 PAN domain Qn_am_d_aIII PF09099.5 KOO22386.1 - 0.34 11.2 4.2 18 5.7 0.0 4.9 5 0 0 5 5 5 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain III Anth_Ig PF05587.8 KOO22386.1 - 0.48 10.3 0.0 1.8e+02 2.0 0.0 5.3 6 0 0 6 6 6 0 Anthrax receptor extracellular domain Popeye PF04831.8 KOO22386.1 - 0.81 9.4 0.0 2.1 8.0 0.0 1.6 1 0 0 1 1 1 0 Popeye protein conserved region IF4E PF01652.13 KOO22387.1 - 3.8e-08 33.0 0.0 4.3e-08 32.8 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E BT1 PF03092.11 KOO22388.1 - 3.3e-104 348.9 3.8 4.2e-104 348.6 2.7 1.0 1 0 0 1 1 1 1 BT1 family MFS_1 PF07690.11 KOO22388.1 - 5.6e-11 41.7 33.5 8.9e-11 41.0 23.2 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Transgly PF00912.17 KOO22388.1 - 0.015 14.6 0.0 0.026 13.8 0.0 1.3 1 0 0 1 1 1 0 Transglycosylase Abhydrolase_6 PF12697.2 KOO22389.1 - 6.2e-35 121.1 0.4 7.3e-35 120.9 0.3 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO22389.1 - 8.5e-17 61.2 0.0 1.6e-16 60.4 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO22389.1 - 9.6e-17 61.2 0.1 7.6e-10 38.7 0.0 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 KOO22389.1 - 5.6e-05 22.4 0.2 0.00087 18.5 0.1 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Thioesterase PF00975.15 KOO22389.1 - 0.00018 21.8 0.1 0.00022 21.5 0.1 1.2 1 0 0 1 1 1 1 Thioesterase domain DLH PF01738.13 KOO22389.1 - 0.0037 16.5 0.0 0.44 9.7 0.0 2.1 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_4 PF08386.5 KOO22389.1 - 0.0096 15.7 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_2 PF02230.11 KOO22389.1 - 0.025 14.0 0.1 0.29 10.5 0.0 2.0 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase PhoPQ_related PF10142.4 KOO22389.1 - 0.083 11.3 0.0 0.1 11.0 0.0 1.2 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein Esterase PF00756.15 KOO22389.1 - 0.13 11.6 0.2 0.19 11.1 0.1 1.2 1 0 0 1 1 1 0 Putative esterase GH3 PF03321.8 KOO22391.1 - 1.5e-93 314.1 0.0 1.4e-91 307.6 0.0 2.0 1 1 0 1 1 1 1 GH3 auxin-responsive promoter Pro_isomerase PF00160.16 KOO22392.1 - 9.5e-37 126.5 0.2 1.1e-36 126.3 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Myb_DNA-binding PF00249.26 KOO22393.1 - 3e-23 81.6 0.0 2.1e-10 40.4 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO22393.1 - 3.3e-19 68.7 0.4 1.4e-08 34.6 0.0 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Herpes_TAF50 PF03326.8 KOO22393.1 - 8.4 5.2 12.9 0.058 12.3 3.0 1.6 2 0 0 2 2 2 0 Herpesvirus transcription activation factor (transactivator) LRR_6 PF13516.1 KOO22394.1 - 1.8e-09 36.6 16.9 1 9.6 0.0 8.9 9 0 0 9 9 9 3 Leucine Rich repeat LRR_1 PF00560.28 KOO22394.1 - 5.5e-08 31.7 3.7 3.9 7.8 0.0 6.9 8 0 0 8 8 8 2 Leucine Rich Repeat LRR_4 PF12799.2 KOO22394.1 - 4.1e-07 29.4 7.8 1 9.0 0.3 5.6 4 2 0 4 4 4 4 Leucine Rich repeats (2 copies) Skp1 PF01466.14 KOO22394.1 - 0.0031 17.5 0.0 0.0076 16.2 0.0 1.6 1 0 0 1 1 1 1 Skp1 family, dimerisation domain LRR_8 PF13855.1 KOO22394.1 - 0.007 16.1 8.7 31 4.4 0.0 6.0 5 2 0 5 5 5 0 Leucine rich repeat LRR_7 PF13504.1 KOO22394.1 - 0.17 12.1 9.2 1.3e+02 3.5 0.0 6.8 8 0 0 8 8 8 0 Leucine rich repeat A_deaminase PF00962.17 KOO22395.1 - 1e-43 149.5 0.0 1.3e-43 149.1 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase MutL_C PF08676.6 KOO22395.1 - 0.0031 17.1 0.0 0.74 9.4 0.0 2.3 2 0 0 2 2 2 2 MutL C terminal dimerisation domain Amidohydro_3 PF07969.6 KOO22395.1 - 0.0044 16.2 2.5 0.0068 15.6 0.3 2.2 1 1 1 2 2 2 1 Amidohydrolase family Amidohydro_1 PF01979.15 KOO22395.1 - 0.035 13.7 0.0 0.067 12.8 0.0 1.5 1 0 0 1 1 1 0 Amidohydrolase family DUF3349 PF11829.3 KOO22395.1 - 0.13 12.6 0.2 1.2 9.6 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3349) EF-hand_1 PF00036.27 KOO22396.1 - 6e-11 40.8 4.4 7.3e-05 21.7 0.0 3.1 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO22396.1 - 1.1e-10 41.4 1.0 6.9e-10 38.9 0.3 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO22396.1 - 1.8e-09 36.5 6.6 7.4e-06 25.0 0.1 3.1 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO22396.1 - 3.4e-07 29.5 2.9 0.0045 16.7 0.0 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO22396.1 - 0.0001 21.8 2.9 0.24 11.0 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair UBA PF00627.26 KOO22396.1 - 0.012 15.4 1.4 3.7 7.5 0.1 3.7 3 0 0 3 3 3 0 UBA/TS-N domain DUF666 PF05006.7 KOO22396.1 - 0.051 13.5 0.0 0.099 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF666) Sel1 PF08238.7 KOO22397.1 - 1e-60 200.8 55.4 1.2e-08 35.2 1.6 11.9 12 0 0 12 12 12 11 Sel1 repeat Peptidase_M16 PF00675.15 KOO22398.1 - 1.4e-27 96.3 0.1 4.3e-27 94.7 0.0 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 KOO22398.1 - 4.5e-24 85.1 0.0 2.8e-14 53.2 0.0 2.7 2 0 0 2 2 2 2 Peptidase M16 inactive domain NUDIX PF00293.23 KOO22398.1 - 0.0058 16.2 0.5 0.02 14.5 0.1 2.0 2 0 0 2 2 2 1 NUDIX domain Met_10 PF02475.11 KOO22399.1 - 3e-44 151.0 0.0 1.6e-43 148.6 0.0 2.0 1 1 0 1 1 1 1 Met-10+ like-protein Pyr_redox_2 PF07992.9 KOO22399.1 - 2.3e-34 119.0 0.7 3.8e-34 118.3 0.5 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 KOO22399.1 - 3.4e-33 113.9 0.2 8.2e-33 112.7 0.2 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 KOO22399.1 - 6.7e-18 64.8 3.0 9.1e-15 54.8 0.1 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOO22399.1 - 1.9e-05 24.8 0.3 9.2e-05 22.5 0.2 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 KOO22399.1 - 2.1e-05 23.5 5.2 0.00059 18.8 0.5 3.1 3 0 0 3 3 3 1 FAD binding domain FAD_oxidored PF12831.2 KOO22399.1 - 5.2e-05 22.5 0.8 0.00013 21.2 0.5 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.19 KOO22399.1 - 0.0012 17.8 1.9 0.0012 17.8 1.3 3.4 3 1 1 4 4 4 1 FAD dependent oxidoreductase HI0933_like PF03486.9 KOO22399.1 - 0.0014 17.1 2.5 0.015 13.7 0.5 2.8 3 0 0 3 3 3 1 HI0933-like protein FAD_binding_3 PF01494.14 KOO22399.1 - 0.0043 16.1 4.4 0.14 11.1 0.1 2.4 2 0 0 2 2 2 2 FAD binding domain Methyltransf_26 PF13659.1 KOO22399.1 - 0.0047 16.9 6.4 0.019 15.0 0.2 3.9 4 1 0 4 4 4 1 Methyltransferase domain NAD_binding_8 PF13450.1 KOO22399.1 - 0.013 15.5 0.7 0.013 15.5 0.5 2.3 2 0 0 2 2 1 0 NAD(P)-binding Rossmann-like domain GIDA PF01134.17 KOO22399.1 - 0.053 12.3 4.7 0.021 13.7 0.6 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A 3HCDH_N PF02737.13 KOO22399.1 - 0.077 12.6 2.5 5.4 6.6 0.3 2.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K_oxygenase PF13434.1 KOO22399.1 - 0.095 11.5 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Methyltransf_18 PF12847.2 KOO22399.1 - 0.097 13.2 0.1 11 6.5 0.0 2.7 2 0 0 2 2 2 0 Methyltransferase domain 2-Hacid_dh_C PF02826.14 KOO22399.1 - 0.13 11.4 1.4 3.3 6.8 0.0 2.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FmrO PF07091.6 KOO22399.1 - 0.17 10.8 0.0 0.29 10.0 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) AlaDh_PNT_C PF01262.16 KOO22399.1 - 0.18 11.3 0.7 14 5.1 0.1 2.4 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain TRM PF02005.11 KOO22399.1 - 0.25 10.1 0.0 0.41 9.5 0.0 1.2 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Clat_adaptor_s PF01217.15 KOO22400.1 - 3.1e-23 82.0 2.0 3.6e-23 81.8 1.4 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain ADP_ribosyl_GH PF03747.9 KOO22400.1 - 0.053 13.2 0.0 0.063 13.0 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosylglycohydrolase Methyltransf_21 PF05050.7 KOO22401.1 - 1.1e-10 41.6 0.0 1.4e-10 41.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase FkbM domain Adeno_E3_CR2 PF02439.10 KOO22401.1 - 0.078 12.5 0.5 0.13 11.8 0.3 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Abhydrolase_6 PF12697.2 KOO22402.1 - 2e-24 86.7 7.4 3.5e-24 85.9 5.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO22402.1 - 1.1e-23 83.9 0.0 1.3e-22 80.5 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 KOO22402.1 - 2.1e-10 40.5 0.0 9.4e-10 38.4 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.5 KOO22402.1 - 0.0014 18.5 0.0 0.0034 17.2 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein Peptidase_S9 PF00326.16 KOO22402.1 - 0.021 14.0 0.0 0.16 11.2 0.0 2.0 2 0 0 2 2 2 0 Prolyl oligopeptidase family EF-hand_6 PF13405.1 KOO22403.1 - 7.1e-14 50.3 0.1 0.001 18.7 0.0 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.27 KOO22403.1 - 3.5e-13 47.8 0.0 0.00049 19.2 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_5 PF13202.1 KOO22403.1 - 5.7e-11 41.2 0.4 0.017 14.4 0.1 3.7 3 0 0 3 3 3 3 EF hand Kelch_3 PF13415.1 KOO22403.1 - 1.3e-09 37.9 0.4 1.7e-07 31.2 0.0 3.0 2 0 0 2 2 2 1 Galactose oxidase, central domain EF-hand_7 PF13499.1 KOO22403.1 - 1.3e-09 38.0 0.0 3.4e-06 27.1 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO22403.1 - 3.1e-08 33.0 0.0 0.00049 19.6 0.0 3.4 2 1 1 3 3 3 2 EF-hand domain pair Kelch_4 PF13418.1 KOO22403.1 - 2.6e-07 30.2 2.7 0.003 17.3 0.0 3.8 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO22403.1 - 6.5e-06 25.9 0.6 0.026 14.4 0.0 3.5 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.10 KOO22403.1 - 0.032 14.0 0.0 13 5.7 0.0 2.8 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.1 KOO22403.1 - 0.041 14.0 0.0 13 6.1 0.0 2.6 2 0 0 2 2 2 0 Kelch motif Sigma54_activat PF00158.21 KOO22403.1 - 0.09 12.2 0.8 0.19 11.1 0.6 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain FKBP_C PF00254.23 KOO22404.1 - 4.4e-18 65.0 0.0 8e-18 64.2 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase PapD-like PF14874.1 KOO22405.1 - 1.3e-09 37.8 0.1 2.6e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Flagellar-associated PapD-like PT PF04886.7 KOO22407.1 - 0.006 15.8 16.5 0.015 14.5 11.4 1.7 1 0 0 1 1 1 1 PT repeat TFIIA PF03153.8 KOO22407.1 - 2.1 8.1 17.4 2.3 8.0 7.3 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit WD40 PF00400.27 KOO22408.1 - 1.8e-41 138.5 13.9 6e-10 38.6 0.0 7.0 8 0 0 8 8 8 6 WD domain, G-beta repeat eIF2A PF08662.6 KOO22408.1 - 2.3e-11 43.7 0.0 0.00014 21.6 0.0 2.9 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.11 KOO22408.1 - 5.9e-06 24.8 0.1 0.035 12.3 0.1 2.2 1 1 1 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.3 KOO22408.1 - 0.001 17.3 1.4 0.07 11.2 0.0 2.7 1 1 2 3 3 3 2 Nucleoporin Nup120/160 IKI3 PF04762.7 KOO22408.1 - 0.011 13.6 0.2 0.052 11.3 0.1 2.2 1 1 0 2 2 2 0 IKI3 family PD40 PF07676.7 KOO22408.1 - 0.014 15.0 0.2 0.24 11.0 0.0 3.0 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.9 KOO22408.1 - 0.016 13.9 0.0 0.13 11.0 0.0 2.3 1 1 2 3 3 3 0 Coatomer WD associated region DPPIV_N PF00930.16 KOO22408.1 - 0.065 11.7 0.1 1.8 7.0 0.0 3.0 3 1 1 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region GH114_assoc PF14741.1 KOO22408.1 - 0.072 12.8 0.1 3.1 7.5 0.0 2.5 2 0 0 2 2 2 0 N-terminal glycosyl-hydrolase-114-associated domain FlgD_ig PF13860.1 KOO22408.1 - 0.1 12.3 0.1 16 5.2 0.0 2.8 2 1 0 2 2 2 0 FlgD Ig-like domain Myb_DNA-binding PF00249.26 KOO22409.1 - 4.6e-28 97.0 2.8 2.6e-14 52.9 0.9 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO22409.1 - 1.1e-21 76.7 0.6 8.9e-15 54.5 0.2 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.5 KOO22409.1 - 0.011 15.5 0.0 0.098 12.3 0.0 2.1 2 0 0 2 2 2 0 SLIDE Myb_DNA-bind_4 PF13837.1 KOO22409.1 - 0.69 10.0 6.1 2 8.6 0.2 2.9 2 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain Shisa PF13908.1 KOO22410.1 - 0.016 15.4 3.6 0.019 15.1 2.5 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator G3P_acyltransf PF02660.10 KOO22410.1 - 0.024 14.2 0.2 0.03 13.9 0.1 1.1 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase DUF677 PF05055.7 KOO22410.1 - 3 6.4 5.1 3.7 6.1 3.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF677) FAP PF07174.6 KOO22410.1 - 7.5 5.7 26.9 8.3 5.6 18.6 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) CDC27 PF09507.5 KOO22410.1 - 8.1 5.5 8.0 9.8 5.2 5.5 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 LsmAD PF06741.8 KOO22411.1 - 5.9e-17 61.5 1.9 1.1e-16 60.6 1.3 1.5 1 0 0 1 1 1 1 LsmAD domain SM-ATX PF14438.1 KOO22411.1 - 1.4e-07 31.2 0.0 2.9e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Ataxin 2 SM domain PAM2 PF07145.10 KOO22411.1 - 0.0044 16.4 0.3 0.0083 15.5 0.2 1.5 1 0 0 1 1 1 1 Ataxin-2 C-terminal region CotE PF10628.4 KOO22411.1 - 0.13 11.5 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 Outer spore coat protein E (CotE) PsbP PF01789.11 KOO22412.1 - 1.1e-05 24.8 0.0 1.4e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 PsbP Arf PF00025.16 KOO22413.1 - 2.5e-29 101.7 0.0 3.3e-29 101.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 KOO22413.1 - 9.2e-07 28.3 0.0 1.1e-06 28.1 0.0 1.4 1 1 0 1 1 1 1 Ras family NACHT PF05729.7 KOO22413.1 - 4.5e-05 23.1 0.2 0.17 11.5 0.0 2.2 1 1 1 2 2 2 2 NACHT domain Miro PF08477.8 KOO22413.1 - 0.00011 22.6 0.0 0.00021 21.7 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein SRP54 PF00448.17 KOO22413.1 - 0.0032 16.9 0.1 0.0069 15.8 0.1 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain G-alpha PF00503.15 KOO22413.1 - 0.1 11.2 5.1 0.34 9.5 0.0 2.8 3 0 0 3 3 3 0 G-protein alpha subunit DUF3138 PF11336.3 KOO22413.1 - 0.1 10.7 5.7 0.15 10.2 4.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) NTPase_1 PF03266.10 KOO22413.1 - 0.11 12.1 0.4 0.33 10.6 0.1 1.8 2 0 0 2 2 2 0 NTPase MobB PF03205.9 KOO22413.1 - 0.16 11.6 0.5 0.54 9.9 0.0 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Septin PF00735.13 KOO22413.1 - 0.34 9.8 1.3 0.41 9.6 0.1 1.7 2 0 0 2 2 2 0 Septin AAA_25 PF13481.1 KOO22413.1 - 0.45 9.8 3.6 0.2 11.0 0.2 2.0 2 1 0 2 2 2 0 AAA domain PH_6 PF15406.1 KOO22413.1 - 0.54 10.3 2.8 0.71 9.9 0.0 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain PV-1 PF06637.6 KOO22413.1 - 2.1 6.8 6.2 2.9 6.3 4.3 1.1 1 0 0 1 1 1 0 PV-1 protein (PLVAP) IKI3 PF04762.7 KOO22414.1 - 0.0073 14.1 0.1 0.015 13.1 0.1 1.3 1 1 0 1 1 1 1 IKI3 family HSP70 PF00012.15 KOO22416.1 - 2.5e-43 147.9 0.1 2.5e-43 147.9 0.1 3.2 2 1 0 2 2 2 1 Hsp70 protein ParG PF09274.5 KOO22416.1 - 0.022 14.6 0.4 12 5.8 0.0 2.8 3 0 0 3 3 3 0 ParG EF-hand_1 PF00036.27 KOO22417.1 - 1.3e-15 55.3 1.0 2.2e-05 23.4 0.0 4.9 6 0 0 6 6 6 2 EF hand EF-hand_6 PF13405.1 KOO22417.1 - 4.6e-14 50.9 3.0 8.1e-06 25.3 0.0 4.4 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.1 KOO22417.1 - 2.3e-13 50.0 2.5 6e-10 39.1 0.1 4.1 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO22417.1 - 5.3e-12 45.1 0.2 1.5e-07 30.9 0.1 4.2 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO22417.1 - 1.3e-11 43.2 2.0 0.00011 21.3 0.0 4.2 4 0 0 4 4 4 2 EF hand HEAT_2 PF13646.1 KOO22417.1 - 0.18 12.1 6.7 0.13 12.5 0.2 3.8 3 2 0 3 3 3 0 HEAT repeats RRP7 PF12923.2 KOO22417.1 - 2.1 8.3 7.2 1.9 8.5 0.1 2.7 2 1 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) LRR_6 PF13516.1 KOO22418.1 - 1.5e-05 24.5 0.4 0.39 10.9 0.0 4.6 4 0 0 4 4 4 2 Leucine Rich repeat SusD-like_2 PF12771.2 KOO22419.1 - 0.01 14.2 0.0 0.015 13.6 0.0 1.1 1 0 0 1 1 1 0 Starch-binding associating with outer membrane TPR_14 PF13428.1 KOO22420.1 - 5.7e-08 32.7 31.2 0.25 12.1 0.4 9.4 5 2 6 11 11 11 4 Tetratricopeptide repeat TPR_19 PF14559.1 KOO22420.1 - 4.1e-06 27.0 9.8 0.092 13.0 0.0 6.6 5 2 3 8 8 8 2 Tetratricopeptide repeat Suf PF05843.9 KOO22420.1 - 6.9e-06 25.9 0.0 0.0028 17.4 0.0 3.1 3 0 0 3 3 3 1 Suppressor of forked protein (Suf) Apc3 PF12895.2 KOO22420.1 - 8.8e-05 22.5 1.1 0.027 14.6 0.2 2.6 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 KOO22420.1 - 0.001 18.8 15.0 1.6 8.7 0.3 6.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO22420.1 - 0.0096 16.5 25.7 0.031 14.9 0.1 6.3 4 2 4 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.1 KOO22420.1 - 0.14 11.8 6.3 2.8 7.6 0.2 4.2 3 1 0 3 3 3 0 TPR repeat DUF3703 PF12487.3 KOO22420.1 - 0.28 10.8 5.1 2.1 8.0 0.3 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3703) TPR_12 PF13424.1 KOO22420.1 - 0.77 9.7 15.5 5.1 7.1 0.2 5.7 4 2 3 7 7 6 0 Tetratricopeptide repeat DSHCT PF08148.7 KOO22421.1 - 7.6e-51 171.8 0.0 3.6e-49 166.4 0.0 2.5 2 0 0 2 2 2 1 DSHCT (NUC185) domain rRNA_proc-arch PF13234.1 KOO22421.1 - 7.2e-32 110.6 0.0 7.2e-31 107.3 0.0 2.1 1 1 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.24 KOO22421.1 - 1.1e-19 70.6 0.0 2.1e-19 69.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO22421.1 - 1.6e-08 34.2 0.0 3.8e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO22421.1 - 0.0021 17.9 0.0 0.0037 17.1 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit LRR_6 PF13516.1 KOO22422.1 - 3e-06 26.7 11.7 3 8.1 0.0 8.1 7 0 0 7 7 7 1 Leucine Rich repeat LRR_8 PF13855.1 KOO22422.1 - 0.059 13.1 12.3 0.077 12.7 1.7 4.4 3 2 1 4 4 4 0 Leucine rich repeat LRR_1 PF00560.28 KOO22422.1 - 0.21 11.7 9.4 1.2e+02 3.3 0.0 7.0 7 1 1 8 8 8 0 Leucine Rich Repeat LRR_7 PF13504.1 KOO22422.1 - 0.46 10.9 6.0 81 4.1 0.2 6.2 6 0 0 6 6 6 0 Leucine rich repeat Band_7 PF01145.20 KOO22423.1 - 7.4e-30 104.1 0.7 7.4e-30 104.1 0.5 1.8 1 1 1 2 2 2 1 SPFH domain / Band 7 family EF-hand_8 PF13833.1 KOO22423.1 - 5.8e-10 38.6 0.8 4.5e-09 35.7 0.1 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO22423.1 - 1e-09 36.9 0.2 0.00082 18.5 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO22423.1 - 8.9e-09 34.3 0.4 0.0029 16.8 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO22423.1 - 2e-08 33.4 0.1 0.0063 16.2 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO22423.1 - 8.4e-07 29.0 0.0 1.5e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair Band_7_1 PF13421.1 KOO22423.1 - 0.016 14.7 0.0 0.028 13.9 0.0 1.4 1 0 0 1 1 1 0 SPFH domain-Band 7 family Beta_helix PF13229.1 KOO22424.1 - 1.3e-39 135.5 10.9 2.7e-17 62.9 0.1 3.6 2 1 2 4 4 4 3 Right handed beta helix region cNMP_binding PF00027.24 KOO22424.1 - 1.2e-31 108.3 0.0 9.9e-16 57.3 0.0 3.6 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain Pkinase PF00069.20 KOO22424.1 - 9e-24 84.0 0.0 1.6e-23 83.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain NosD PF05048.8 KOO22424.1 - 2.1e-19 69.6 0.0 1e-07 31.3 0.0 3.3 1 1 2 3 3 3 3 Periplasmic copper-binding protein (NosD) Ax_dynein_light PF10211.4 KOO22424.1 - 2.7e-07 30.6 2.9 7e-07 29.2 2.0 1.7 1 0 0 1 1 1 1 Axonemal dynein light chain Pkinase_Tyr PF07714.12 KOO22424.1 - 0.001 18.1 0.0 0.002 17.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Patched PF02460.13 KOO22425.1 - 1.5e-05 23.2 0.1 2.3e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.3 KOO22425.1 - 0.0058 16.1 5.1 0.0058 16.1 3.5 2.2 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation RRM_1 PF00076.17 KOO22428.1 - 2.5e-11 43.0 0.1 6.2e-10 38.5 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO22428.1 - 1.6e-09 37.6 0.0 3.2e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO22428.1 - 6.2e-06 25.9 0.0 1.4e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PWI PF01480.12 KOO22428.1 - 0.0028 17.7 0.0 0.0055 16.7 0.0 1.4 1 0 0 1 1 1 1 PWI domain Nup35_RRM_2 PF14605.1 KOO22428.1 - 0.091 12.5 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF1330 PF07045.6 KOO22428.1 - 0.16 11.8 0.0 0.16 11.8 0.0 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1330) Amidase PF01425.16 KOO22429.1 - 3.3e-85 286.5 3.9 3.8e-85 286.3 2.7 1.0 1 0 0 1 1 1 1 Amidase Ion_trans PF00520.26 KOO22430.1 - 1.9e-163 539.8 44.2 1.4e-45 154.9 2.9 4.4 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 KOO22430.1 - 0.0014 17.1 1.6 0.0014 17.1 1.1 9.7 10 1 1 11 11 11 7 Polycystin cation channel Pkinase_Tyr PF07714.12 KOO22431.1 - 4.8e-08 32.3 0.0 1.1e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 KOO22431.1 - 1.5e-07 30.8 0.0 3.1e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 KOO22431.1 - 2.5e-06 26.7 0.0 5.4e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Kinase-like HEAT PF02985.17 KOO22431.1 - 7.3e-06 25.6 2.2 0.64 10.2 0.0 4.8 5 0 0 5 5 5 2 HEAT repeat Vac14_Fab1_bd PF12755.2 KOO22431.1 - 0.1 12.9 0.2 5.4 7.4 0.0 3.0 1 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region Imm16 PF15565.1 KOO22431.1 - 0.12 12.2 0.0 1.1 9.1 0.0 2.4 2 0 0 2 2 2 0 Immunity protein 16 ShK PF01549.19 KOO22432.1 - 8.2e-19 67.6 37.9 2.1e-08 34.3 5.3 3.7 3 0 0 3 3 3 3 ShK domain-like 2OG-FeII_Oxy_3 PF13640.1 KOO22432.1 - 2.9e-08 34.1 0.1 8.6e-08 32.6 0.0 1.9 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO22432.1 - 3.1e-05 24.1 0.0 5.8e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily LRR_6 PF13516.1 KOO22433.1 - 2.4e-13 48.6 18.1 0.00093 19.0 0.0 6.7 5 2 0 5 5 5 4 Leucine Rich repeat LRR_4 PF12799.2 KOO22433.1 - 0.0001 21.8 3.7 4.7 6.9 0.6 4.5 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO22433.1 - 0.0002 20.9 0.5 42 4.7 0.0 5.6 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_7 PF13504.1 KOO22433.1 - 1.4 9.4 10.6 25 5.6 0.0 5.3 5 1 0 5 5 5 0 Leucine rich repeat H_PPase PF03030.11 KOO22434.1 - 7.1e-137 457.5 22.6 8.3e-137 457.2 15.7 1.0 1 0 0 1 1 1 1 Inorganic H+ pyrophosphatase PAGK PF15284.1 KOO22434.1 - 0.063 13.0 0.0 0.2 11.3 0.0 1.8 1 0 0 1 1 1 0 Phage-encoded virulence factor HCaRG PF07258.9 KOO22435.1 - 9.8e-19 67.5 0.0 1.2e-18 67.2 0.0 1.0 1 0 0 1 1 1 1 HCaRG protein Hpt PF01627.18 KOO22435.1 - 0.27 11.2 3.4 6.9 6.7 0.1 3.1 2 1 0 2 2 2 0 Hpt domain THDPS_M PF14789.1 KOO22437.1 - 0.07 13.0 1.4 0.25 11.3 0.0 2.6 2 1 1 3 3 3 0 Tetrahydrodipicolinate N-succinyltransferase middle PRA1 PF03208.14 KOO22438.1 - 4.8e-21 74.7 0.7 6e-21 74.3 0.5 1.1 1 0 0 1 1 1 1 PRA1 family protein UBA PF00627.26 KOO22438.1 - 3.5e-07 29.8 0.1 6.3e-07 29.0 0.1 1.4 1 0 0 1 1 1 1 UBA/TS-N domain HTH_8 PF02954.14 KOO22438.1 - 0.0071 15.8 0.6 0.014 14.9 0.4 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family Ribosomal_L20 PF00453.13 KOO22438.1 - 0.065 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L20 BACK PF07707.10 KOO22439.1 - 1.1e-19 70.1 1.0 1.6e-19 69.6 0.7 1.2 1 0 0 1 1 1 1 BTB And C-terminal Kelch DUF2153 PF09921.4 KOO22439.1 - 0.057 13.0 0.3 0.14 11.7 0.1 1.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2153) 2OG-FeII_Oxy_3 PF13640.1 KOO22440.1 - 5.6e-10 39.6 0.1 1.9e-09 37.9 0.1 1.9 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO22440.1 - 0.00014 21.4 0.5 0.00036 20.1 0.4 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO22440.1 - 0.11 12.8 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DUF4586 PF15239.1 KOO22442.1 - 9.7e-42 143.5 21.8 8.6e-41 140.4 15.1 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4586) DUF730 PF05325.6 KOO22443.1 - 0.12 12.2 3.3 0.37 10.6 0.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF730) DUF1811 PF08838.5 KOO22443.1 - 0.42 10.5 5.9 0.081 12.8 0.7 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1811) DUF3512 PF12024.3 KOO22443.1 - 0.74 9.0 0.0 0.74 9.0 0.0 3.4 2 2 2 5 5 5 0 Domain of unknown function (DUF3512) Glu_syn_central PF04898.9 KOO22443.1 - 1.6 7.9 6.8 1 8.5 1.8 2.1 2 0 0 2 2 2 0 Glutamate synthase central domain His_biosynth PF00977.16 KOO22445.1 - 1.7e-45 155.0 0.8 1.2e-44 152.2 0.5 2.4 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.23 KOO22445.1 - 3.1e-31 108.3 0.0 4.4e-31 107.8 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.9 KOO22445.1 - 1.3e-09 37.8 0.0 2.4e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.14 KOO22445.1 - 7.8e-07 28.9 0.0 1.1e-05 25.1 0.0 2.2 1 1 0 1 1 1 1 SNO glutamine amidotransferase family Peptidase_C26 PF07722.8 KOO22445.1 - 0.0011 18.5 0.0 0.0082 15.6 0.0 2.1 1 1 0 1 1 1 1 Peptidase C26 Dus PF01207.12 KOO22445.1 - 0.074 11.8 0.1 0.14 10.9 0.1 1.4 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) ThiG PF05690.9 KOO22445.1 - 1.8 7.5 4.9 0.23 10.5 0.3 1.9 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG TPR_11 PF13414.1 KOO22446.1 - 5.9e-12 45.0 7.4 1.6e-10 40.4 3.3 2.4 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.12 KOO22446.1 - 1.6e-06 27.5 6.4 0.0057 16.4 0.1 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO22446.1 - 2e-06 28.2 8.2 0.00016 22.2 0.2 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO22446.1 - 7.5e-06 25.3 6.7 0.0065 16.0 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO22446.1 - 1.2e-05 25.1 0.4 0.00076 19.4 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO22446.1 - 6.8e-05 23.1 3.0 0.013 16.0 0.1 3.0 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO22446.1 - 0.0025 18.0 4.9 0.19 12.0 0.3 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO22446.1 - 0.019 14.7 2.9 2.7 7.9 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO22446.1 - 0.024 14.4 0.1 0.69 9.8 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_15 PF13429.1 KOO22446.1 - 0.042 12.8 1.3 0.18 10.8 0.1 2.3 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO22446.1 - 0.093 12.6 3.2 0.46 10.4 0.1 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat zf-C4H2 PF10146.4 KOO22446.1 - 1.1 9.1 4.4 2.3 8.1 3.0 1.5 1 0 0 1 1 1 0 Zinc finger-containing protein DUF2360 PF10152.4 KOO22446.1 - 8.1 6.7 6.9 1.2 9.4 1.5 1.9 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) KIAA1430 PF13879.1 KOO22447.1 - 0.00067 20.0 0.0 0.00067 20.0 0.0 2.5 2 1 0 2 2 2 1 KIAA1430 homologue EF-hand_1 PF00036.27 KOO22447.1 - 0.0084 15.3 0.2 0.031 13.5 0.0 2.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO22447.1 - 0.078 12.9 0.1 0.43 10.5 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain Trehalase PF01204.13 KOO22449.1 - 0.0053 15.4 0.0 0.008 14.8 0.0 1.1 1 0 0 1 1 1 1 Trehalase Glyco_hydro_92 PF07971.7 KOO22449.1 - 0.14 10.7 3.4 0.99 7.9 2.4 1.8 1 1 1 2 2 2 0 Glycosyl hydrolase family 92 Asp_protease_2 PF13650.1 KOO22450.1 - 9.3e-05 22.8 0.0 0.00019 21.8 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease EF-hand_7 PF13499.1 KOO22451.1 - 5.8e-29 100.0 3.2 1.3e-10 41.2 0.2 5.3 4 1 1 5 5 5 5 EF-hand domain pair EF-hand_6 PF13405.1 KOO22451.1 - 1.5e-26 89.8 7.1 0.0035 17.1 0.0 7.9 8 0 0 8 8 8 6 EF-hand domain EF-hand_1 PF00036.27 KOO22451.1 - 7e-26 87.5 0.7 0.00028 19.9 0.2 7.6 7 1 0 7 7 7 6 EF hand EF-hand_5 PF13202.1 KOO22451.1 - 2.5e-20 70.8 4.1 0.0016 17.6 0.2 6.7 6 1 0 6 6 6 6 EF hand EF-hand_8 PF13833.1 KOO22451.1 - 5.5e-20 70.7 2.2 5.8e-10 38.6 0.3 5.9 5 1 1 6 6 6 4 EF-hand domain pair EF-hand_10 PF14788.1 KOO22451.1 - 4.3e-05 23.0 0.2 5.9 6.6 0.0 4.7 5 0 0 5 5 5 2 EF hand SPARC_Ca_bdg PF10591.4 KOO22451.1 - 0.012 15.6 0.0 0.94 9.5 0.0 3.6 4 2 0 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOO22451.1 - 0.017 15.0 0.1 1.1 9.2 0.0 3.3 3 1 1 4 4 4 0 EF-hand domain HTH_20 PF12840.2 KOO22452.1 - 0.085 12.6 0.0 0.41 10.4 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain L-fibroin PF05849.6 KOO22452.1 - 0.086 12.1 0.2 0.32 10.2 0.1 1.8 2 0 0 2 2 2 0 Fibroin light chain (L-fibroin) Epimerase PF01370.16 KOO22454.1 - 3.8e-17 62.5 0.0 6.5e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 KOO22454.1 - 8e-10 38.0 0.0 3.4e-09 36.0 0.0 1.8 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.14 KOO22454.1 - 9.6e-08 31.0 0.0 2.9e-07 29.4 0.0 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 KOO22454.1 - 3.5e-07 30.3 0.0 1.1e-06 28.6 0.0 1.9 1 0 0 1 1 1 1 short chain dehydrogenase RmlD_sub_bind PF04321.12 KOO22454.1 - 0.0023 16.8 0.0 0.0077 15.1 0.0 1.7 1 1 0 1 1 1 1 RmlD substrate binding domain KR PF08659.5 KOO22454.1 - 0.0024 17.5 1.0 0.021 14.4 0.7 2.3 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 KOO22454.1 - 0.01 15.8 0.3 1.1 9.2 0.2 2.4 1 1 0 1 1 1 0 NADH(P)-binding PI3Ka PF00613.15 KOO22456.1 - 9.4e-59 197.6 0.1 1.8e-58 196.7 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.22 KOO22456.1 - 8.7e-49 166.1 0.0 1.8e-48 165.0 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase cNMP_binding PF00027.24 KOO22456.1 - 5.3e-18 64.6 0.0 8.9e-09 35.0 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain TPR_11 PF13414.1 KOO22458.1 - 3.7e-12 45.7 3.7 6.3e-12 44.9 2.5 1.3 1 0 0 1 1 1 1 TPR repeat TPR_12 PF13424.1 KOO22458.1 - 0.00036 20.4 2.6 0.0012 18.7 1.6 1.9 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO22458.1 - 0.00089 18.9 9.1 0.013 15.3 1.4 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO22458.1 - 0.002 17.6 8.7 0.0027 17.2 1.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO22458.1 - 0.018 15.2 2.4 4.1 7.8 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO22458.1 - 0.065 13.9 1.7 0.065 13.9 1.2 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOO22458.1 - 0.14 11.9 0.4 0.33 10.8 0.3 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Apc3 PF12895.2 KOO22458.1 - 0.32 11.1 5.0 1.5 9.0 3.2 1.9 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 KOO22458.1 - 0.33 11.6 4.3 1.6 9.5 3.0 2.1 1 1 0 1 1 1 0 Tetratricopeptide repeat RNase_PH_C PF03725.10 KOO22461.1 - 4.4e-06 26.5 0.0 6.2e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Ribonuc_red_lgC PF02867.10 KOO22462.1 - 1.6e-206 687.0 0.0 2e-206 686.7 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 KOO22462.1 - 8.2e-22 76.8 0.0 2.1e-21 75.4 0.0 1.8 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain Engrail_1_C_sig PF10525.4 KOO22462.1 - 0.031 13.3 0.1 0.098 11.8 0.1 1.8 1 0 0 1 1 1 0 Engrailed homeobox C-terminal signature domain HTH_29 PF13551.1 KOO22463.1 - 0.00032 20.7 0.0 0.00072 19.6 0.0 1.7 1 1 1 2 2 2 1 Winged helix-turn helix HTH_23 PF13384.1 KOO22463.1 - 0.00038 20.0 0.2 0.47 10.1 0.0 3.2 3 0 0 3 3 3 2 Homeodomain-like domain HTH_32 PF13565.1 KOO22463.1 - 0.01 16.6 0.0 0.047 14.4 0.0 1.9 2 0 0 2 2 2 0 Homeodomain-like domain HTH_28 PF13518.1 KOO22463.1 - 0.087 12.8 0.2 1.2 9.1 0.0 2.7 2 1 0 2 2 2 0 Helix-turn-helix domain Na_Ca_ex PF01699.19 KOO22465.1 - 5.6e-44 149.1 24.2 1.7e-26 92.4 7.6 2.6 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Calx-beta PF03160.9 KOO22465.1 - 9.6e-20 70.4 0.0 3.4e-17 62.2 0.0 2.6 2 0 0 2 2 2 2 Calx-beta domain DUF1680 PF07944.7 KOO22466.1 - 1.5e-39 135.7 0.0 1.9e-39 135.3 0.0 1.1 1 0 0 1 1 1 1 Putative glycosyl hydrolase of unknown function (DUF1680) Sulfotransfer_3 PF13469.1 KOO22467.1 - 0.00039 21.3 0.3 0.00052 20.9 0.2 1.3 1 0 0 1 1 1 1 Sulfotransferase family adh_short PF00106.20 KOO22468.1 - 8.3e-15 55.0 0.0 1.6e-14 54.1 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOO22468.1 - 5.6e-06 26.1 0.0 1.6e-05 24.6 0.0 1.8 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 KOO22468.1 - 1.5e-05 25.1 0.0 3.2e-05 24.0 0.0 1.6 2 0 0 2 2 2 1 NADH(P)-binding adh_short_C2 PF13561.1 KOO22468.1 - 2.6e-05 24.1 0.0 4.4e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 KOO22468.1 - 4.6e-05 22.9 0.0 7e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 KOO22468.1 - 0.00061 18.7 0.0 0.0011 17.8 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain Oxidored_nitro PF00148.14 KOO22468.1 - 0.0022 16.6 0.0 0.0033 16.1 0.0 1.2 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase Eno-Rase_NADH_b PF12242.3 KOO22468.1 - 0.017 14.9 0.1 0.048 13.4 0.0 1.8 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF309 PF03745.9 KOO22468.1 - 0.037 13.4 0.1 0.082 12.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF309) 3Beta_HSD PF01073.14 KOO22468.1 - 0.14 10.8 0.2 0.2 10.3 0.2 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family zf-C2HC_2 PF13913.1 KOO22469.1 - 6e-14 51.2 13.3 2.6e-08 33.3 1.7 2.4 2 0 0 2 2 2 2 zinc-finger of a C2HC-type TIP39 PF14980.1 KOO22469.1 - 0.067 12.8 1.7 0.22 11.1 1.1 1.9 1 0 0 1 1 1 0 TIP39 peptide Histone_HNS PF00816.16 KOO22470.1 - 0.0025 18.2 2.6 0.13 12.7 0.2 2.3 1 1 0 2 2 2 2 H-NS histone family MerR-DNA-bind PF09278.6 KOO22470.1 - 0.035 14.5 0.6 0.11 12.9 0.1 2.0 2 0 0 2 2 2 0 MerR, DNA binding Methyltransf_23 PF13489.1 KOO22471.1 - 1.5e-05 24.7 0.0 2.3e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO22471.1 - 0.12 12.9 0.0 0.29 11.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Synuclein PF01387.12 KOO22471.1 - 0.17 11.8 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 Synuclein TauD PF02668.11 KOO22474.1 - 2.6e-33 115.7 0.0 3.7e-33 115.2 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Aldo_ket_red PF00248.16 KOO22474.1 - 9.5e-13 47.5 0.0 1.7e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 Aldo/keto reductase family Arm PF00514.18 KOO22475.1 - 0.00013 21.6 0.6 1 9.2 0.0 3.6 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Alkyl_sulf_dimr PF14863.1 KOO22475.1 - 0.97 9.6 3.5 19 5.4 0.3 2.3 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation Histidinol_dh PF00815.15 KOO22475.1 - 6.7 5.2 12.9 3.2 6.2 1.1 2.5 1 1 2 3 3 3 0 Histidinol dehydrogenase ABC_tran PF00005.22 KOO22476.1 - 2.9e-44 150.6 0.0 6.6e-21 75.0 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.2 KOO22476.1 - 3.8e-43 147.8 27.6 2e-24 86.2 4.1 3.3 3 0 0 3 3 3 2 ABC-2 family transporter protein AAA_21 PF13304.1 KOO22476.1 - 1.5e-21 77.6 0.0 5.4e-08 33.1 0.0 4.2 4 0 0 4 4 4 3 AAA domain SRCR PF00530.13 KOO22476.1 - 2.6e-15 56.5 0.4 6.4e-15 55.2 0.3 1.7 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain AAA_23 PF13476.1 KOO22476.1 - 9.8e-05 22.7 0.2 0.041 14.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.14 KOO22476.1 - 0.00012 21.4 0.0 0.47 9.6 0.0 3.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.1 KOO22476.1 - 0.001 18.9 0.0 4.6 7.2 0.0 3.8 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit SRP54 PF00448.17 KOO22476.1 - 0.16 11.3 0.2 19 4.6 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_29 PF13555.1 KOO22476.1 - 0.24 10.9 5.0 3.2 7.3 0.1 3.1 3 0 0 3 3 3 0 P-loop containing region of AAA domain DUF258 PF03193.11 KOO22476.1 - 0.28 10.3 0.1 4.8 6.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Miro PF08477.8 KOO22476.1 - 0.37 11.2 0.1 19 5.7 0.0 2.5 2 0 0 2 2 2 0 Miro-like protein DUF87 PF01935.12 KOO22476.1 - 1.4 8.6 1.0 31 4.2 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_24 PF13479.1 KOO22476.1 - 2.6 7.5 0.5 32 4.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.1 KOO22476.1 - 2.7 6.9 0.0 25 3.7 0.0 2.3 4 0 0 4 4 4 0 AAA ATPase domain Gcd10p PF04189.8 KOO22476.1 - 3.7 6.5 0.0 6 5.9 0.0 1.2 1 0 0 1 1 1 0 Gcd10p family DUF3584 PF12128.3 KOO22476.1 - 3.7 4.7 0.8 28 1.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) DAGK_acc PF00609.14 KOO22477.1 - 0.037 14.1 1.3 0.16 12.1 0.2 2.2 2 0 0 2 2 2 0 Diacylglycerol kinase accessory domain Flu_NS2 PF00601.14 KOO22477.1 - 2.7 8.2 8.7 4.7 7.4 0.4 3.2 3 1 0 3 3 3 0 Influenza non-structural protein (NS2) ATP-synt_B PF00430.13 KOO22478.1 - 9 6.1 11.1 12 5.6 7.7 1.3 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Apolipoprotein PF01442.13 KOO22479.1 - 0.00014 21.4 39.4 0.00014 21.4 27.3 3.5 2 1 1 3 3 3 2 Apolipoprotein A1/A4/E domain GAS PF13851.1 KOO22479.1 - 3.4 6.8 33.2 6.5 5.9 3.7 3.2 1 1 3 4 4 4 0 Growth-arrest specific micro-tubule binding UxaC PF02614.9 KOO22480.1 - 8.5e-80 268.6 0.0 1e-79 268.3 0.0 1.0 1 0 0 1 1 1 1 Glucuronate isomerase DnaJ PF00226.26 KOO22481.1 - 8.4e-21 73.4 0.0 1.3e-20 72.9 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 KOO22481.1 - 3.7e-16 58.8 0.1 6.3e-15 54.8 0.0 2.4 2 0 0 2 2 2 1 DnaJ C terminal domain GAS PF13851.1 KOO22482.1 - 0.02 14.0 20.6 0.021 14.0 11.0 2.3 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding TruB_N PF01509.13 KOO22482.1 - 2.1 8.5 9.1 4.3 7.4 0.5 2.4 1 1 1 2 2 2 0 TruB family pseudouridylate synthase (N terminal domain) ATG16 PF08614.6 KOO22482.1 - 6.9 6.4 44.2 1 9.1 12.9 3.1 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) HEAT PF02985.17 KOO22483.1 - 2e-22 77.2 10.2 8.5e-05 22.3 0.0 11.6 13 0 0 13 13 13 4 HEAT repeat HEAT_2 PF13646.1 KOO22483.1 - 4.5e-21 74.9 10.7 5.5e-07 29.7 0.0 8.4 6 2 4 10 10 10 6 HEAT repeats HEAT_EZ PF13513.1 KOO22483.1 - 2.3e-10 40.6 30.2 0.00099 19.5 0.1 12.2 10 6 8 18 18 18 5 HEAT-like repeat Vac14_Fab1_bd PF12755.2 KOO22483.1 - 1.3e-08 35.0 0.2 0.056 13.8 0.0 6.5 5 3 1 6 6 6 1 Vacuolar 14 Fab1-binding region RIX1 PF08167.7 KOO22483.1 - 0.00016 21.4 0.1 0.3 10.7 0.0 5.0 5 1 0 6 6 6 1 rRNA processing/ribosome biogenesis MMS19_C PF12460.3 KOO22483.1 - 0.0054 15.5 0.0 0.22 10.1 0.0 3.5 3 2 1 4 4 4 1 RNAPII transcription regulator C-terminal Cohesin_HEAT PF12765.2 KOO22483.1 - 0.013 15.4 0.0 8.5 6.4 0.0 3.7 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion CLASP_N PF12348.3 KOO22483.1 - 0.054 12.8 9.6 0.54 9.5 0.0 4.9 6 1 0 6 6 6 0 CLASP N terminal HEAT_PBS PF03130.11 KOO22483.1 - 0.065 13.7 6.1 6.8 7.4 0.7 5.7 4 1 0 4 4 4 0 PBS lyase HEAT-like repeat Arm PF00514.18 KOO22483.1 - 0.082 12.7 12.0 21 5.1 0.1 7.4 8 0 0 8 8 8 0 Armadillo/beta-catenin-like repeat EF-hand_6 PF13405.1 KOO22485.1 - 2.4e-16 58.0 0.1 0.039 13.8 0.0 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO22485.1 - 4.4e-16 58.7 0.2 3.7e-07 30.1 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO22485.1 - 1.1e-14 52.4 0.0 0.0091 15.2 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO22485.1 - 7.1e-12 44.7 0.0 0.0016 17.9 0.0 3.6 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO22485.1 - 3.4e-05 22.9 1.8 8.1 5.9 0.0 4.7 4 0 0 4 4 4 4 EF hand DUF4205 PF13898.1 KOO22487.1 - 2e-47 161.6 0.0 6.2e-36 123.8 0.0 2.8 3 0 0 3 3 3 2 Domain of unknown function (DUF4205) EF-hand_1 PF00036.27 KOO22487.1 - 0.016 14.4 0.0 0.062 12.6 0.0 2.1 3 0 0 3 3 3 0 EF hand EF-hand_9 PF14658.1 KOO22487.1 - 0.019 14.8 0.0 0.05 13.5 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain EF-hand_6 PF13405.1 KOO22487.1 - 0.055 13.3 0.0 0.36 10.8 0.0 2.3 3 0 0 3 3 3 0 EF-hand domain EF-hand_7 PF13499.1 KOO22487.1 - 0.17 12.0 0.0 0.39 10.8 0.0 1.6 1 1 0 1 1 1 0 EF-hand domain pair GHMP_kinases_C PF08544.8 KOO22487.1 - 1 9.5 0.0 1 9.5 0.0 3.2 4 0 0 4 4 4 0 GHMP kinases C terminal COX5B PF01215.14 KOO22488.1 - 3.8e-05 23.3 0.0 0.00012 21.7 0.0 1.7 2 0 0 2 2 2 1 Cytochrome c oxidase subunit Vb zf-ZPR1 PF03367.8 KOO22489.1 - 1.2e-10 40.7 0.0 1.8e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 ZPR1 zinc-finger domain YjgF_endoribonc PF14588.1 KOO22491.1 - 3.7e-26 91.8 0.0 4.1e-26 91.6 0.0 1.0 1 0 0 1 1 1 1 YjgF/chorismate_mutase-like, putative endoribonuclease Ribonuc_L-PSP PF01042.16 KOO22491.1 - 2.7e-17 62.6 0.0 4.3e-17 61.9 0.0 1.3 1 1 0 1 1 1 1 Endoribonuclease L-PSP Ank_2 PF12796.2 KOO22492.1 - 1.5e-15 57.2 0.3 3.3e-15 56.1 0.2 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO22492.1 - 6.4e-15 54.1 1.2 1.6e-06 27.6 0.1 3.8 3 0 0 3 3 3 2 Ankyrin repeat 2OG-FeII_Oxy PF03171.15 KOO22492.1 - 3e-14 53.1 0.0 4.9e-14 52.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 KOO22492.1 - 4.6e-13 49.7 0.0 7.7e-13 48.9 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Ank_4 PF13637.1 KOO22492.1 - 4.8e-13 49.2 0.0 2.4e-08 34.2 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO22492.1 - 6.3e-10 38.9 0.5 5e-08 32.9 0.1 3.4 1 1 2 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO22492.1 - 2.6e-07 30.2 0.1 0.0055 16.8 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Hist_deacetyl PF00850.14 KOO22493.1 - 9.4e-56 189.3 0.5 1.2e-55 189.0 0.3 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Optomotor-blind PF11078.3 KOO22493.1 - 0.23 11.8 2.9 0.51 10.7 2.0 1.5 1 0 0 1 1 1 0 Optomotor-blind protein N-terminal region mRNA_cap_enzyme PF01331.14 KOO22495.1 - 2.3e-13 50.2 0.0 2.8e-13 49.9 0.0 1.0 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain DNA_ligase_A_M PF01068.16 KOO22495.1 - 0.013 14.9 0.0 0.025 13.9 0.0 1.5 1 1 0 1 1 1 0 ATP dependent DNA ligase domain Img2 PF05046.9 KOO22496.1 - 3.8e-16 59.1 0.0 6.2e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) SUI1 PF01253.17 KOO22496.1 - 0.0014 18.3 0.0 0.0019 17.9 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 LRR_6 PF13516.1 KOO22497.1 - 2.3e-12 45.6 11.5 0.22 11.6 0.1 8.3 9 0 0 9 9 9 5 Leucine Rich repeat LRR_8 PF13855.1 KOO22497.1 - 0.00021 20.9 3.8 0.15 11.8 0.5 3.0 2 0 0 2 2 2 2 Leucine rich repeat LRR_1 PF00560.28 KOO22497.1 - 0.00035 20.2 1.2 12 6.3 0.1 5.7 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_4 PF12799.2 KOO22497.1 - 0.0004 19.9 5.6 0.18 11.4 0.1 3.7 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO22497.1 - 0.18 12.1 4.0 2e+02 2.9 0.0 5.8 6 0 0 6 6 6 0 Leucine rich repeat WD40 PF00400.27 KOO22498.1 - 3.4e-49 163.0 15.1 1.4e-11 43.7 0.2 8.0 7 1 1 8 8 8 7 WD domain, G-beta repeat Nup160 PF11715.3 KOO22498.1 - 0.0005 18.3 0.3 0.63 8.1 0.0 3.1 2 1 1 3 3 3 3 Nucleoporin Nup120/160 Viral_env_E26 PF11050.3 KOO22499.1 - 0.0079 15.4 0.0 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 Virus envelope protein E26 Fib_alpha PF08702.5 KOO22499.1 - 0.057 13.5 4.1 0.098 12.7 2.8 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family RHD3 PF05879.7 KOO22500.1 - 0.0019 16.2 0.0 0.0025 15.8 0.0 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) PNPase PF03726.9 KOO22502.1 - 2.1 8.6 8.7 0.48 10.7 0.7 2.8 2 0 0 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain Anoctamin PF04547.7 KOO22503.1 - 2.5e-98 329.6 0.0 5.4e-98 328.5 0.0 1.6 1 1 0 1 1 1 1 Calcium-activated chloride channel DnaJ PF00226.26 KOO22504.1 - 6.9e-14 51.3 0.9 1.4e-13 50.3 0.2 1.8 2 0 0 2 2 2 1 DnaJ domain HSP90 PF00183.13 KOO22505.1 - 2e-82 277.3 0.0 4.7e-81 272.8 0.0 2.0 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.1 KOO22505.1 - 1.2e-14 54.1 0.5 2.2e-14 53.2 0.3 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 KOO22505.1 - 1.4e-09 37.6 0.2 3e-09 36.5 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ATP-synt_C PF00137.16 KOO22507.1 - 5.5e-28 96.6 35.9 2.3e-14 53.0 9.2 2.1 2 0 0 2 2 2 2 ATP synthase subunit C PT-VENN PF04829.8 KOO22507.1 - 0.94 9.0 10.1 61 3.2 6.5 2.7 1 1 0 1 1 1 0 Pre-toxin domain with VENN motif EF-hand_6 PF13405.1 KOO22510.1 - 1.6e-05 24.3 0.3 6.6e-05 22.4 0.1 2.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.1 KOO22510.1 - 8e-05 22.7 0.0 0.00019 21.4 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO22510.1 - 0.00019 20.5 0.1 0.00055 19.0 0.1 1.9 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.1 KOO22510.1 - 0.00056 19.1 0.4 0.0027 16.9 0.2 2.2 2 0 0 2 2 2 1 EF hand UPF0197 PF05251.7 KOO22510.1 - 0.0063 16.7 3.1 0.0097 16.1 1.2 2.0 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0197) UT PF03253.9 KOO22511.1 - 9.2e-51 172.5 28.0 1.3e-50 171.9 19.4 1.2 1 0 0 1 1 1 1 Urea transporter Methyltransf_31 PF13847.1 KOO22511.1 - 0.0041 16.7 0.0 0.0071 15.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO22511.1 - 0.0048 17.3 0.0 0.014 15.8 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO22511.1 - 0.0067 16.9 0.0 0.032 14.8 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO22511.1 - 0.071 13.4 0.3 0.48 10.8 0.2 2.4 1 1 0 1 1 1 0 Methyltransferase domain Rsm22 PF09243.5 KOO22511.1 - 0.13 11.3 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 FAA_hydrolase PF01557.13 KOO22513.1 - 3.1e-51 173.9 0.0 4e-51 173.5 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Tub_2 PF04525.7 KOO22514.1 - 0.019 14.3 0.0 0.024 14.0 0.0 1.1 1 0 0 1 1 1 0 Tubby C 2 TPR_11 PF13414.1 KOO22515.1 - 3.2e-07 29.8 3.4 5.6e-06 25.9 0.3 3.1 4 0 0 4 4 4 1 TPR repeat TPR_2 PF07719.12 KOO22515.1 - 0.00022 20.9 2.3 0.04 13.8 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO22515.1 - 0.0022 17.5 0.0 0.0089 15.5 0.0 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO22515.1 - 0.0024 17.9 0.4 0.16 12.2 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO22515.1 - 0.0062 17.0 3.0 0.0062 17.0 2.1 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO22515.1 - 0.0072 16.9 20.9 0.017 15.7 3.0 4.7 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO22515.1 - 0.0091 15.8 3.4 0.0091 15.8 2.3 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO22515.1 - 0.25 11.6 7.2 0.14 12.5 0.7 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO22515.1 - 7.5 6.5 8.1 1.3 8.9 0.4 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3275 PF11679.3 KOO22516.1 - 0.1 12.2 3.3 0.15 11.6 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) Phospholamban PF04272.9 KOO22516.1 - 0.63 9.5 2.9 56 3.2 0.1 3.2 1 1 2 3 3 3 0 Phospholamban TPR_11 PF13414.1 KOO22517.1 - 1.8e-12 46.7 13.6 9.7e-11 41.1 2.5 3.7 1 1 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 KOO22517.1 - 1.3e-09 37.2 3.4 0.0087 15.6 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.1 KOO22517.1 - 2.5e-07 30.4 3.7 2.5e-07 30.4 2.5 3.5 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO22517.1 - 7e-07 28.6 15.7 0.003 17.3 0.1 4.6 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO22517.1 - 7.2e-06 26.5 1.1 7.2e-06 26.5 0.8 6.3 4 1 4 8 8 4 3 Tetratricopeptide repeat Aha1_N PF09229.6 KOO22517.1 - 1.4e-05 24.9 0.0 3.5e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal TPR_12 PF13424.1 KOO22517.1 - 0.00048 20.0 0.2 0.00048 20.0 0.1 3.6 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO22517.1 - 0.0013 18.9 1.7 0.0013 18.9 1.2 3.9 3 1 0 3 3 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO22517.1 - 0.011 16.3 0.4 0.011 16.3 0.3 7.3 5 2 2 7 7 7 0 Tetratricopeptide repeat TPR_17 PF13431.1 KOO22517.1 - 0.062 13.5 0.1 6.2 7.2 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Viral_NABP PF05515.6 KOO22517.1 - 0.12 12.6 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 Viral nucleic acid binding O-FucT PF10250.4 KOO22517.1 - 0.2 10.7 0.0 1 8.4 0.0 2.1 1 1 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase TPR_8 PF13181.1 KOO22517.1 - 0.31 10.9 2.8 55 3.8 0.2 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO22517.1 - 6.8 6.6 6.7 11 6.0 0.1 3.1 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Ion_trans PF00520.26 KOO22518.1 - 1.9e-13 50.1 1.9 3e-13 49.4 1.3 1.3 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO22518.1 - 1.2e-06 28.0 4.1 1.2e-06 28.0 2.8 2.5 3 0 0 3 3 3 1 Ion channel cNMP_binding PF00027.24 KOO22518.1 - 0.041 13.7 0.0 0.077 12.8 0.0 1.4 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain TTL PF03133.10 KOO22520.1 - 4.3e-07 29.1 0.0 5.1e-07 28.8 0.0 1.0 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family N2227 PF07942.7 KOO22521.1 - 5.3e-53 179.7 0.0 7.2e-53 179.2 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein NNMT_PNMT_TEMT PF01234.12 KOO22521.1 - 0.0055 15.7 0.0 0.0082 15.1 0.0 1.2 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_11 PF08241.7 KOO22521.1 - 0.03 14.8 0.1 0.26 11.7 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_18 PF12847.2 KOO22521.1 - 0.036 14.6 0.1 0.15 12.6 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 KOO22521.1 - 0.098 12.3 0.0 0.2 11.3 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_26 PF13659.1 KOO22522.1 - 1.1e-09 38.3 1.9 2.4e-09 37.2 0.3 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO22522.1 - 1.5e-07 32.0 0.2 6.6e-07 29.8 0.0 2.2 3 0 0 3 3 2 1 Methyltransferase domain PrmA PF06325.8 KOO22522.1 - 0.00012 21.3 0.0 0.00019 20.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 KOO22522.1 - 0.00015 21.1 0.0 0.00027 20.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.1 KOO22522.1 - 0.00043 19.8 0.0 0.00075 19.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO22522.1 - 0.0023 17.6 0.0 0.004 16.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO22522.1 - 0.0065 16.9 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 KOO22522.1 - 0.0075 15.3 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_24 PF13578.1 KOO22522.1 - 0.0083 16.9 0.1 0.052 14.3 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_16 PF10294.4 KOO22522.1 - 0.016 14.6 0.0 0.033 13.6 0.0 1.5 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_25 PF13649.1 KOO22522.1 - 0.072 13.4 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain RabGAP-TBC PF00566.13 KOO22524.1 - 5e-13 49.0 0.0 5.9e-13 48.7 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain FliG_N PF14842.1 KOO22525.1 - 0.023 14.7 0.1 0.094 12.8 0.1 2.0 2 1 0 2 2 2 0 FliG N-terminal domain p25-alpha PF05517.7 KOO22525.1 - 0.11 12.7 0.1 0.28 11.4 0.1 1.7 1 1 0 1 1 1 0 p25-alpha DUF3708 PF12501.3 KOO22527.1 - 0.0055 16.5 2.4 0.0055 16.5 1.7 2.0 1 1 1 2 2 2 1 Phosphate ATP-binding cassette transporter RNase_H2-Ydr279 PF09468.5 KOO22527.1 - 0.031 13.4 8.1 0.048 12.8 5.6 1.3 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) DUF1501 PF07394.7 KOO22527.1 - 0.87 8.3 4.9 0.94 8.2 3.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Peptidase_S30 PF01577.11 KOO22527.1 - 1.4 8.2 15.3 1.7 7.9 10.6 1.0 1 0 0 1 1 1 0 Potyvirus P1 protease DUF572 PF04502.8 KOO22527.1 - 2 7.5 16.1 2.5 7.2 11.1 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) RR_TM4-6 PF06459.7 KOO22527.1 - 2.4 7.9 12.3 3.4 7.4 8.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ycf1 PF05758.7 KOO22527.1 - 4.9 4.7 6.8 5.4 4.6 4.7 1.0 1 0 0 1 1 1 0 Ycf1 DUF4407 PF14362.1 KOO22527.1 - 6.4 5.6 17.0 8.8 5.1 11.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TATR PF03430.8 KOO22527.1 - 6.6 5.2 10.1 8.4 4.8 7.0 1.0 1 0 0 1 1 1 0 Trans-activating transcriptional regulator mTERF PF02536.9 KOO22528.1 - 1e-10 40.7 0.0 1.7e-05 23.6 0.0 2.5 1 1 1 2 2 2 2 mTERF cNMP_binding PF00027.24 KOO22529.1 - 8.2e-09 35.1 0.0 1.2e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain TBPIP PF07106.8 KOO22530.1 - 2e-18 66.5 0.0 2.6e-18 66.1 0.0 1.1 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Swi5 PF07061.6 KOO22530.1 - 0.011 15.5 5.0 0.032 14.0 0.3 2.5 1 1 1 2 2 2 0 Swi5 IncA PF04156.9 KOO22530.1 - 0.013 15.0 7.7 0.018 14.6 5.3 1.1 1 0 0 1 1 1 0 IncA protein HTH_IclR PF09339.5 KOO22530.1 - 0.024 14.2 3.6 0.42 10.2 0.0 3.2 3 0 0 3 3 3 0 IclR helix-turn-helix domain Mnd1 PF03962.10 KOO22530.1 - 0.11 12.1 3.0 0.16 11.6 2.1 1.3 1 0 0 1 1 1 0 Mnd1 family DUF724 PF05266.9 KOO22530.1 - 0.95 9.0 4.1 1.7 8.2 2.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) MORN PF02493.15 KOO22531.1 - 0.00012 21.6 4.3 0.0052 16.4 0.5 3.2 3 0 0 3 3 3 2 MORN repeat DUF922 PF06037.6 KOO22531.1 - 0.089 12.1 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF922) Kinesin PF00225.18 KOO22532.1 - 3.6e-100 334.9 0.0 4.7e-100 334.5 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain CRAL_TRIO PF00650.15 KOO22532.1 - 4.6e-30 104.2 0.0 9.3e-30 103.2 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 KOO22532.1 - 0.004 17.2 0.0 0.012 15.7 0.0 1.8 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain GATase_4 PF13230.1 KOO22532.1 - 0.08 11.6 0.0 0.25 9.9 0.0 1.7 2 0 0 2 2 2 0 Glutamine amidotransferases class-II PIF1 PF05970.9 KOO22532.1 - 0.14 11.0 0.2 0.29 10.0 0.1 1.4 1 0 0 1 1 1 0 PIF1-like helicase zf-CCHC_3 PF13917.1 KOO22533.1 - 0.00015 21.3 0.7 0.00015 21.3 0.5 2.4 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.18 KOO22533.1 - 0.0013 18.5 5.1 0.0013 18.5 3.5 2.4 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_5 PF14787.1 KOO22533.1 - 0.011 15.1 2.4 0.011 15.1 1.6 1.9 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Fer4_9 PF13187.1 KOO22533.1 - 0.07 13.4 1.3 0.13 12.5 0.5 1.8 2 0 0 2 2 2 0 4Fe-4S dicluster domain Phage_Gp19 PF09355.5 KOO22533.1 - 1.3 8.8 4.5 12 5.7 0.3 2.5 2 0 0 2 2 2 0 Phage protein Gp19/Gp15/Gp42 Rotamase_2 PF13145.1 KOO22533.1 - 9.5 6.8 10.9 0.58 10.8 0.2 2.8 3 0 0 3 3 3 0 PPIC-type PPIASE domain RPAP2_Rtr1 PF04181.8 KOO22534.1 - 7.7e-18 64.3 0.0 1.4e-17 63.4 0.0 1.5 1 0 0 1 1 1 1 Rtr1/RPAP2 family Ank PF00023.25 KOO22535.1 - 6.9e-163 521.0 70.9 4.7e-09 35.6 0.0 21.7 21 1 0 21 21 21 21 Ankyrin repeat Ank_2 PF12796.2 KOO22535.1 - 3.4e-150 488.8 60.7 4.6e-20 71.7 2.2 10.9 1 1 8 10 10 10 10 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO22535.1 - 8.3e-111 350.6 34.8 6.3e-05 22.8 0.0 21.1 21 0 0 21 21 21 20 Ankyrin repeat Ank_5 PF13857.1 KOO22535.1 - 1.3e-102 333.5 47.8 1.2e-09 38.0 0.2 19.2 2 2 18 20 20 20 19 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO22535.1 - 6.3e-99 322.8 21.0 1.4e-10 41.3 0.1 13.1 6 3 7 14 14 14 14 Ankyrin repeats (many copies) UBA PF00627.26 KOO22535.1 - 2.9e-09 36.4 26.9 36 4.3 0.0 16.1 18 0 0 18 18 18 0 UBA/TS-N domain p25-alpha PF05517.7 KOO22536.1 - 0.00027 21.1 0.0 18 5.5 0.0 4.3 4 0 0 4 4 4 2 p25-alpha EF-hand_1 PF00036.27 KOO22536.1 - 0.47 9.8 4.1 7.9 6.0 0.0 4.2 4 0 0 4 4 4 0 EF hand EF-hand_1 PF00036.27 KOO22538.1 - 3.2e-12 44.7 0.0 5.4e-05 22.2 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO22538.1 - 3.3e-12 45.1 0.1 3e-05 23.5 0.0 2.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO22538.1 - 5.3e-11 42.4 0.3 1.3e-07 31.5 0.0 2.0 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO22538.1 - 9.8e-11 40.4 0.1 1.7e-05 23.9 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO22538.1 - 6.3e-10 38.5 0.2 5.4e-05 22.7 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair Peptidase_M50B PF13398.1 KOO22539.1 - 0.098 12.0 0.6 0.13 11.5 0.4 1.2 1 0 0 1 1 1 0 Peptidase M50B-like CHZ PF09649.5 KOO22539.1 - 0.34 10.1 0.1 0.34 10.1 0.1 2.1 3 0 0 3 3 3 0 Histone chaperone domain CHZ Apc4_WD40 PF12894.2 KOO22540.1 - 3.8e-15 55.1 0.0 3.1e-14 52.1 0.0 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.27 KOO22540.1 - 2.6e-08 33.4 0.4 7.5e-06 25.6 0.1 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat Apc4 PF12896.2 KOO22540.1 - 6.5e-08 32.1 0.2 9.5e-08 31.5 0.2 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 TPR_MLP1_2 PF07926.7 KOO22540.1 - 0.045 13.4 0.1 0.074 12.8 0.0 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein IKI3 PF04762.7 KOO22540.1 - 0.056 11.2 0.1 0.4 8.4 0.0 1.9 1 1 1 2 2 2 0 IKI3 family TPR_MLP1_2 PF07926.7 KOO22541.1 - 0.016 14.9 0.2 0.029 14.1 0.1 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Rootletin PF15035.1 KOO22541.1 - 0.045 13.7 0.2 0.092 12.7 0.2 1.4 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion CRAL_TRIO PF00650.15 KOO22543.1 - 8.4e-17 61.1 0.0 9.5e-17 60.9 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.1 KOO22543.1 - 5.1e-06 26.4 0.0 5.6e-06 26.3 0.0 1.0 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain TcpE PF12648.2 KOO22543.1 - 0.069 13.2 0.3 0.092 12.9 0.2 1.2 1 0 0 1 1 1 0 TcpE family UPF0051 PF01458.12 KOO22544.1 - 6.8e-69 231.8 0.0 9.4e-69 231.3 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein family (UPF0051) LRR_4 PF12799.2 KOO22545.1 - 6.6e-15 54.3 0.5 6.6e-05 22.4 0.0 3.7 2 2 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO22545.1 - 7.8e-09 35.1 2.2 4.3e-05 23.1 0.0 2.9 2 1 2 4 4 4 3 Leucine rich repeat LRR_9 PF14580.1 KOO22545.1 - 2.3e-07 30.5 0.0 4.5e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Leucine-rich repeat LRR_1 PF00560.28 KOO22545.1 - 0.0001 21.8 2.0 6.2 7.2 0.2 4.8 4 1 0 4 4 4 2 Leucine Rich Repeat LRR_6 PF13516.1 KOO22545.1 - 0.0013 18.5 0.9 37 4.8 0.1 4.3 3 1 1 4 4 4 0 Leucine Rich repeat LRR_7 PF13504.1 KOO22545.1 - 0.0061 16.5 7.8 5.7 7.6 0.2 5.3 4 1 0 4 4 4 1 Leucine rich repeat Ank_2 PF12796.2 KOO22546.1 - 4.1e-13 49.4 0.2 5e-05 23.5 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO22546.1 - 6.4e-08 32.5 6.1 0.00033 20.8 0.1 4.5 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO22546.1 - 2.3e-07 31.1 4.8 0.0062 17.0 0.1 4.8 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO22546.1 - 3.1e-07 29.8 8.5 0.62 9.9 0.2 4.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.1 KOO22546.1 - 3.6e-05 23.5 2.6 3.7 8.0 0.0 5.2 5 0 0 5 5 5 1 Ankyrin repeat zf-DHHC PF01529.15 KOO22546.1 - 0.081 12.3 0.0 0.14 11.5 0.0 1.4 1 1 0 1 1 1 0 DHHC palmitoyltransferase LRR_6 PF13516.1 KOO22547.1 - 3.4e-51 165.5 7.9 0.00076 19.2 0.0 10.5 10 0 0 10 10 10 9 Leucine Rich repeat LRR_1 PF00560.28 KOO22547.1 - 1.3e-07 30.6 0.0 68 4.0 0.0 8.6 10 0 0 10 10 10 0 Leucine Rich Repeat LRR_4 PF12799.2 KOO22547.1 - 3.6e-06 26.4 12.9 1.2 8.8 0.0 6.8 4 2 4 8 8 8 3 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO22547.1 - 9.4e-06 25.0 13.9 54 4.6 0.0 9.8 10 0 0 10 10 10 0 Leucine rich repeat Flu_M1 PF00598.14 KOO22547.1 - 0.0005 19.4 4.2 11 5.3 0.2 4.7 2 1 2 5 5 5 2 Influenza Matrix protein (M1) LRR_8 PF13855.1 KOO22547.1 - 0.00096 18.8 15.1 2 8.2 0.3 6.1 4 3 2 6 6 6 3 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO22547.1 - 0.0059 16.7 7.8 7.5 6.8 0.3 5.5 3 1 3 6 6 6 2 RNA 2'-O ribose methyltransferase substrate binding DUF4396 PF14342.1 KOO22547.1 - 0.015 15.3 2.6 1.7 8.7 0.1 3.2 2 2 1 3 3 3 0 Domain of unknown function (DUF4396) CbiG_N PF11760.3 KOO22547.1 - 0.082 12.6 30.2 11 5.8 0.1 8.4 3 3 6 9 9 9 0 Cobalamin synthesis G N-terminal DUF2202 PF09968.4 KOO22547.1 - 0.3 10.7 7.0 57 3.3 0.0 5.2 1 1 3 5 5 5 0 Uncharacterized protein domain (DUF2202) 2-Hacid_dh_C PF02826.14 KOO22549.1 - 4.3e-33 113.9 0.0 6.9e-33 113.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 KOO22549.1 - 3.4e-18 65.3 0.0 5.7e-18 64.6 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 KOO22549.1 - 4.1e-05 23.4 0.1 0.00015 21.6 0.0 2.0 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase ACT PF01842.20 KOO22549.1 - 0.00044 19.6 0.0 0.001 18.4 0.0 1.6 1 0 0 1 1 1 1 ACT domain ELFV_dehydrog PF00208.16 KOO22549.1 - 0.022 14.3 0.0 0.047 13.2 0.0 1.5 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase DUF1350 PF07082.6 KOO22549.1 - 0.038 13.0 0.0 0.092 11.7 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1350) SNF2_N PF00176.18 KOO22550.1 - 2.6e-44 151.2 0.0 1.4e-43 148.8 0.0 2.1 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOO22550.1 - 7.9e-10 38.4 0.0 2.3e-09 36.9 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO22550.1 - 3.5e-06 26.9 0.0 8.6e-06 25.6 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF3138 PF11336.3 KOO22550.1 - 0.034 12.3 1.1 0.21 9.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) p25-alpha PF05517.7 KOO22551.1 - 0.0016 18.7 0.0 0.002 18.3 0.0 1.2 1 0 0 1 1 1 1 p25-alpha DUF3142 PF11340.3 KOO22552.1 - 0.13 11.8 0.2 0.22 11.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3142) DUF3016 PF11454.3 KOO22552.1 - 0.14 11.7 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3016) DUF2109 PF09882.4 KOO22552.1 - 0.96 9.4 11.7 0.79 9.6 5.4 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2109) ATP_synt_H PF05493.8 KOO22553.1 - 0.0071 16.3 0.3 0.022 14.8 0.2 1.8 1 0 0 1 1 1 1 ATP synthase subunit H TB PF00683.12 KOO22554.1 - 0.068 12.7 0.1 0.11 12.0 0.1 1.3 1 0 0 1 1 1 0 TB domain TerC PF03741.11 KOO22555.1 - 4e-51 173.0 7.8 6.6e-51 172.3 5.4 1.4 1 0 0 1 1 1 1 Integral membrane protein TerC family DUF475 PF04332.10 KOO22555.1 - 0.004 16.7 8.3 0.0056 16.2 5.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF475) Metallophos PF00149.23 KOO22556.1 - 3.8e-27 94.9 0.0 5.8e-27 94.3 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KOO22556.1 - 0.003 17.3 0.0 0.0091 15.8 0.0 1.9 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain rve_3 PF13683.1 KOO22556.1 - 0.023 14.2 0.2 1.7 8.2 0.0 3.2 3 0 0 3 3 3 0 Integrase core domain DUF2026 PF09641.5 KOO22556.1 - 0.026 13.8 0.0 0.046 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2026) EF-hand_1 PF00036.27 KOO22557.1 - 0.082 12.2 0.1 0.23 10.8 0.1 1.7 1 0 0 1 1 1 0 EF hand Ank_2 PF12796.2 KOO22558.1 - 9.8e-27 93.1 6.1 5.4e-16 58.6 0.6 3.1 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO22558.1 - 2.4e-24 83.8 4.4 9.2e-08 31.5 0.2 5.0 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.1 KOO22558.1 - 3.1e-24 84.4 4.7 1.4e-09 37.8 0.4 3.8 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO22558.1 - 1.9e-22 79.1 0.6 9.7e-12 45.0 0.2 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) TPR_11 PF13414.1 KOO22558.1 - 4.9e-20 70.9 10.4 3.1e-15 55.5 0.5 3.0 3 0 0 3 3 3 2 TPR repeat Ank_3 PF13606.1 KOO22558.1 - 4.1e-18 63.6 0.4 0.00032 20.6 0.1 5.1 5 0 0 5 5 5 3 Ankyrin repeat TPR_2 PF07719.12 KOO22558.1 - 8.3e-15 53.4 3.9 0.00032 20.3 0.4 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO22558.1 - 3.7e-12 45.3 2.6 2e-05 24.0 0.6 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO22558.1 - 2.4e-07 30.0 2.1 0.047 13.4 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO22558.1 - 4.1e-07 30.4 14.1 1.6e-05 25.4 0.1 3.5 4 0 0 4 4 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO22558.1 - 4.9e-06 26.7 7.9 0.012 16.1 0.2 4.7 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO22558.1 - 2.6e-05 24.4 1.7 0.3 11.4 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO22558.1 - 3.1e-05 23.8 0.8 0.073 13.2 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOO22558.1 - 3.3e-05 23.7 0.8 0.0015 18.4 0.3 2.6 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO22558.1 - 0.004 16.8 0.2 3.4 7.7 0.1 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO22558.1 - 0.0084 15.9 0.1 0.64 9.9 0.0 3.2 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat SAP PF02037.22 KOO22558.1 - 0.027 14.0 0.5 0.06 12.8 0.4 1.6 1 0 0 1 1 1 0 SAP domain Pro_isomerase PF00160.16 KOO22559.1 - 1.7e-22 80.2 0.0 2.9e-22 79.5 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD ELO PF01151.13 KOO22560.1 - 3.5e-50 170.6 9.6 4.2e-50 170.3 6.6 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Ank PF00023.25 KOO22561.1 - 1.5e-59 194.9 17.6 9.7e-08 31.4 0.0 10.7 11 0 0 11 11 11 10 Ankyrin repeat Ank_2 PF12796.2 KOO22561.1 - 5.9e-56 186.7 12.4 9.7e-16 57.8 0.0 6.4 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO22561.1 - 6e-48 160.4 2.6 3e-08 33.9 0.0 8.4 5 2 4 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO22561.1 - 4.3e-41 134.8 12.3 5.4e-05 23.0 0.0 11.1 11 1 0 11 11 11 9 Ankyrin repeat Ank_5 PF13857.1 KOO22561.1 - 2.8e-33 113.1 14.0 2.1e-07 30.9 0.0 7.6 5 2 3 8 8 8 7 Ankyrin repeats (many copies) BLOC1_2 PF10046.4 KOO22562.1 - 0.0023 18.0 1.0 0.048 13.7 0.1 2.1 2 0 0 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 LZ_Tnp_IS66 PF13007.2 KOO22562.1 - 0.097 13.3 0.4 0.097 13.3 0.2 1.6 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain Syntaxin-6_N PF09177.6 KOO22562.1 - 0.5 10.8 2.7 2.3 8.6 1.9 2.0 1 1 0 1 1 1 0 Syntaxin 6, N-terminal ERM PF00769.14 KOO22563.1 - 0.00042 19.9 4.9 0.00042 19.9 3.4 2.4 2 1 0 2 2 2 1 Ezrin/radixin/moesin family DUF641 PF04859.7 KOO22563.1 - 0.37 10.5 10.7 0.76 9.5 3.2 2.7 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) TMF_DNA_bd PF12329.3 KOO22563.1 - 2.6 7.9 11.6 5.1 6.9 3.9 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding EMP24_GP25L PF01105.19 KOO22564.1 - 4.8e-23 81.8 0.9 5.3e-23 81.6 0.6 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD HXXEE PF13787.1 KOO22564.1 - 0.091 13.1 0.1 0.13 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function with HXXEE motif Ribosomal_L18e PF00828.14 KOO22565.1 - 3.9e-21 75.7 0.1 4.2e-21 75.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 IQ PF00612.22 KOO22566.1 - 0.054 13.1 0.4 0.054 13.1 0.3 4.3 4 0 0 4 4 4 0 IQ calmodulin-binding motif Pept_tRNA_hydro PF01195.14 KOO22567.1 - 1.3e-27 96.5 0.0 1.6e-27 96.2 0.0 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase Myb_DNA-binding PF00249.26 KOO22568.1 - 5.5e-23 80.7 2.1 1.5e-10 40.9 0.1 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO22568.1 - 8.2e-18 64.2 0.3 1.4e-07 31.4 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain PmbA_TldD PF01523.11 KOO22568.1 - 0.0046 16.2 0.0 0.0074 15.6 0.0 1.2 1 0 0 1 1 1 1 Putative modulator of DNA gyrase BTG PF07742.7 KOO22569.1 - 2.7e-15 55.9 0.0 5.1e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 BTG family WD40 PF00400.27 KOO22570.1 - 6.6e-12 44.8 0.2 0.027 14.3 0.0 4.0 3 1 0 3 3 3 3 WD domain, G-beta repeat FPL PF09758.4 KOO22571.1 - 4e-44 149.9 1.3 4.7e-36 123.7 0.3 2.2 2 0 0 2 2 2 2 Uncharacterised conserved protein CRAL_TRIO PF00650.15 KOO22571.1 - 5.9e-08 32.3 0.0 1.2e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain RAI16-like PF10257.4 KOO22571.1 - 1.4e-07 30.8 1.7 3.4e-07 29.5 0.3 2.3 3 0 0 3 3 3 1 Retinoic acid induced 16-like protein GBP PF02263.14 KOO22572.1 - 1.7e-61 207.5 0.0 2.3e-61 207.0 0.0 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.9 KOO22572.1 - 1.1e-16 60.9 0.0 1.1e-16 60.9 0.0 3.7 2 1 2 4 4 4 1 Guanylate-binding protein, C-terminal domain LRR_6 PF13516.1 KOO22573.1 - 8.3e-21 71.6 0.1 0.012 15.5 0.0 6.4 6 0 0 6 6 6 5 Leucine Rich repeat SAP PF02037.22 KOO22573.1 - 1.6e-07 30.6 0.1 5e-07 29.0 0.1 1.9 1 0 0 1 1 1 1 SAP domain LRR_4 PF12799.2 KOO22573.1 - 0.0016 18.0 0.4 0.26 10.9 0.0 3.7 3 2 1 4 4 4 1 Leucine Rich repeats (2 copies) SpoU_sub_bind PF08032.7 KOO22573.1 - 0.029 14.5 3.8 2.2 8.4 0.1 3.9 2 1 2 4 4 4 0 RNA 2'-O ribose methyltransferase substrate binding LRR_8 PF13855.1 KOO22573.1 - 0.03 14.0 0.0 10 5.9 0.0 3.4 3 1 0 3 3 3 0 Leucine rich repeat Skp1 PF01466.14 KOO22573.1 - 0.14 12.2 0.0 0.61 10.1 0.0 2.1 1 0 0 1 1 1 0 Skp1 family, dimerisation domain CbiG_N PF11760.3 KOO22573.1 - 2.8 7.7 9.1 31 4.3 0.2 4.2 3 1 1 4 4 4 0 Cobalamin synthesis G N-terminal CytB6-F_Fe-S PF08802.5 KOO22576.1 - 0.42 10.6 2.3 0.41 10.7 0.3 2.0 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit TPR_MLP1_2 PF07926.7 KOO22577.1 - 0.0047 16.6 8.5 0.0047 16.6 5.9 2.5 2 1 0 2 2 2 1 TPR/MLP1/MLP2-like protein UPF0184 PF03670.8 KOO22577.1 - 0.059 13.5 2.1 0.12 12.5 0.7 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0184) Syntaxin PF00804.20 KOO22577.1 - 0.25 11.5 11.1 2 8.6 7.7 2.5 1 1 0 1 1 1 0 Syntaxin Stk19 PF10494.4 KOO22577.1 - 0.35 10.2 6.1 14 4.9 0.0 3.0 1 1 2 3 3 3 0 Serine-threonine protein kinase 19 Tropomyosin PF00261.15 KOO22577.1 - 0.95 8.5 34.6 2.1 7.3 24.0 1.9 1 1 0 1 1 1 0 Tropomyosin Pox_A_type_inc PF04508.7 KOO22577.1 - 4.4 7.3 7.1 23 5.1 0.4 3.9 2 1 1 3 3 3 0 Viral A-type inclusion protein repeat Lge1 PF11488.3 KOO22577.1 - 6.2 7.1 13.7 2.2 8.5 1.5 3.3 3 0 0 3 3 3 0 Transcriptional regulatory protein LGE1 SPT16 PF08644.6 KOO22577.1 - 7.1 6.4 11.3 6 6.6 1.1 2.3 1 1 1 2 2 2 0 FACT complex subunit (SPT16/CDC68) Spore_coat_CotO PF14153.1 KOO22577.1 - 8.7 5.7 14.7 3.7 6.9 1.9 2.1 2 0 0 2 2 2 0 Spore coat protein CotO Thioredoxin PF00085.15 KOO22578.1 - 4.6e-11 42.3 0.0 5.5e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.11 KOO22578.1 - 0.015 14.0 0.0 0.017 13.8 0.0 1.1 1 0 0 1 1 1 0 Phosducin DUF2997 PF11211.3 KOO22578.1 - 0.065 12.6 0.1 0.12 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2997) DUF4637 PF15470.1 KOO22579.1 - 0.71 9.4 4.4 1.6 8.3 3.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) NOA36 PF06524.7 KOO22579.1 - 2 7.6 6.2 2.3 7.3 4.3 1.2 1 0 0 1 1 1 0 NOA36 protein Fasciclin PF02469.17 KOO22580.1 - 2.6e-35 121.2 0.0 5.8e-35 120.0 0.0 1.6 1 0 0 1 1 1 1 Fasciclin domain Cytadhesin_P30 PF07271.6 KOO22581.1 - 0.0072 15.6 3.1 0.0089 15.3 1.9 1.4 1 1 0 1 1 1 1 Cytadhesin P30/P32 DDRGK PF09756.4 KOO22581.1 - 0.011 15.1 7.7 0.018 14.4 5.4 1.3 1 0 0 1 1 1 0 DDRGK domain DUF385 PF04075.9 KOO22581.1 - 1.5 8.7 6.6 22 5.0 3.6 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF385) Hema_stalk PF08720.5 KOO22582.1 - 0.0044 16.5 0.1 0.012 15.0 0.0 1.8 1 0 0 1 1 1 1 Influenza C hemagglutinin stalk GAS PF13851.1 KOO22582.1 - 0.03 13.5 0.5 0.03 13.5 0.4 5.2 1 1 5 7 7 7 0 Growth-arrest specific micro-tubule binding NPV_P10 PF05531.7 KOO22582.1 - 0.37 11.0 25.0 3.6 7.8 0.5 6.0 4 1 1 5 5 5 0 Nucleopolyhedrovirus P10 protein Reo_sigmaC PF04582.7 KOO22582.1 - 1 8.4 14.9 2 7.5 3.2 3.7 2 2 3 5 5 5 0 Reovirus sigma C capsid protein FdhD-NarQ PF02634.10 KOO22582.1 - 1.3 8.3 7.2 0.39 10.1 1.9 2.1 1 1 1 2 2 2 0 FdhD/NarQ family ART PF01129.13 KOO22583.1 - 2.6e-05 23.4 0.0 4.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.9 KOO22583.1 - 0.00062 19.0 0.0 0.0013 17.9 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme NDK PF00334.14 KOO22584.1 - 3.6e-54 182.1 0.0 4.5e-54 181.9 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Pkinase PF00069.20 KOO22585.1 - 0.0026 16.9 0.1 0.22 10.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain LRR_4 PF12799.2 KOO22585.1 - 0.015 14.9 0.1 0.17 11.5 0.0 2.3 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO22585.1 - 0.017 14.8 0.5 0.25 11.1 0.1 1.9 1 1 1 2 2 2 0 Leucine rich repeat LRR_1 PF00560.28 KOO22585.1 - 0.15 12.2 0.1 1.6 9.0 0.0 2.5 2 0 0 2 2 2 0 Leucine Rich Repeat TFIIS_C PF01096.13 KOO22586.1 - 1.9e-22 78.6 5.1 1.9e-22 78.6 3.5 2.5 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.11 KOO22586.1 - 5.6e-06 25.9 1.1 5.6e-06 25.9 0.7 2.9 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.2 KOO22586.1 - 0.00024 20.8 9.0 0.00058 19.6 1.4 2.3 2 0 0 2 2 2 1 Transposase zinc-ribbon domain C1_1 PF00130.17 KOO22586.1 - 0.00035 20.2 5.9 0.001 18.7 0.1 2.6 2 1 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DZR PF12773.2 KOO22586.1 - 0.0038 17.0 8.1 0.28 11.0 0.1 2.5 2 1 0 2 2 2 2 Double zinc ribbon Nudix_N_2 PF14803.1 KOO22586.1 - 0.01 15.4 8.2 0.029 14.0 0.6 3.2 3 0 0 3 3 3 0 Nudix N-terminal Zn-ribbon_8 PF09723.5 KOO22586.1 - 0.016 15.1 5.1 2.2 8.2 0.3 3.3 3 0 0 3 3 3 0 Zinc ribbon domain Zn_ribbon_recom PF13408.1 KOO22586.1 - 0.017 15.3 3.4 0.53 10.5 0.1 2.9 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain Terminase_GpA PF05876.7 KOO22586.1 - 0.021 13.2 2.6 0.027 12.8 1.8 1.2 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) PHD PF00628.24 KOO22586.1 - 0.036 13.7 5.4 0.22 11.2 0.1 2.9 3 0 0 3 3 3 0 PHD-finger PhnA_Zn_Ribbon PF08274.7 KOO22586.1 - 0.045 13.5 0.3 0.045 13.5 0.2 2.0 2 0 0 2 2 2 0 PhnA Zinc-Ribbon DUF2387 PF09526.5 KOO22586.1 - 0.047 13.6 0.8 0.047 13.6 0.5 1.8 2 0 0 2 2 2 0 Probable metal-binding protein (DUF2387) Lar_restr_allev PF14354.1 KOO22586.1 - 0.19 12.0 3.1 1.6 9.0 0.3 2.2 2 0 0 2 2 2 0 Restriction alleviation protein Lar Tnp_zf-ribbon_2 PF13842.1 KOO22586.1 - 0.36 11.2 0.2 0.36 11.2 0.2 2.8 2 1 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon zinc_ribbon_5 PF13719.1 KOO22586.1 - 0.37 10.4 9.1 0.92 9.1 0.5 3.2 3 0 0 3 3 3 0 zinc-ribbon domain zinc-ribbons_6 PF07191.7 KOO22586.1 - 0.39 10.5 4.6 3.1 7.6 0.9 2.3 2 0 0 2 2 2 0 zinc-ribbons C1_4 PF07975.7 KOO22586.1 - 0.46 10.5 8.6 15 5.7 0.2 3.1 2 1 1 3 3 3 0 TFIIH C1-like domain Rpr2 PF04032.11 KOO22586.1 - 0.66 9.8 5.1 0.54 10.1 0.8 2.4 1 1 1 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain DRP PF06044.7 KOO22586.1 - 0.67 8.9 5.0 4.4 6.2 0.1 2.0 1 1 1 2 2 2 0 Dam-replacing family zinc_ribbon_4 PF13717.1 KOO22586.1 - 0.68 9.6 10.1 1.1 8.9 0.7 3.2 3 0 0 3 3 3 0 zinc-ribbon domain C1_3 PF07649.7 KOO22586.1 - 0.81 9.7 11.5 1.1 9.3 0.1 3.4 4 0 0 4 4 3 0 C1-like domain Elf1 PF05129.8 KOO22586.1 - 2.1 8.0 5.3 2.1 8.1 0.5 2.5 2 2 0 2 2 2 0 Transcription elongation factor Elf1 like Desulfoferrod_N PF06397.7 KOO22586.1 - 2.2 7.7 7.9 2.6 7.4 0.1 2.7 3 0 0 3 3 2 0 Desulfoferrodoxin, N-terminal domain zf-Mss51 PF13824.1 KOO22586.1 - 2.2 8.2 7.3 16 5.4 1.7 2.6 2 1 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 HypA PF01155.14 KOO22586.1 - 2.2 7.9 5.9 2.8 7.6 1.0 2.5 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family DUF4379 PF14311.1 KOO22586.1 - 2.5 7.9 7.8 0.76 9.6 0.5 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4379) OrfB_Zn_ribbon PF07282.6 KOO22586.1 - 3.5 7.3 9.2 7.4 6.3 2.6 2.6 2 1 0 2 2 2 0 Putative transposase DNA-binding domain zf-H2C2_2 PF13465.1 KOO22586.1 - 3.7 8.0 8.5 36 4.8 0.3 3.4 3 0 0 3 3 3 0 Zinc-finger double domain Rubredoxin PF00301.15 KOO22586.1 - 5.2 7.0 12.6 4.1 7.3 0.2 3.8 4 0 0 4 4 4 0 Rubredoxin zf-HIT PF04438.11 KOO22586.1 - 9.4 5.9 15.0 7.1 6.3 0.2 3.9 4 0 0 4 4 4 0 HIT zinc finger TF_Zn_Ribbon PF08271.7 KOO22586.1 - 9.7 5.6 11.5 0.26 10.6 1.3 2.8 2 2 0 2 2 2 0 TFIIB zinc-binding SH2_2 PF14633.1 KOO22587.1 - 5.1e-30 104.1 1.2 1e-29 103.2 0.0 1.9 2 0 0 2 2 2 1 SH2 domain DLD PF14878.1 KOO22587.1 - 4.2e-15 55.8 0.3 4.2e-15 55.8 0.2 3.1 3 0 0 3 3 3 1 Death-like domain of SPT6 HHH_7 PF14635.1 KOO22587.1 - 5.2e-15 55.4 0.0 1.1e-14 54.3 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif SPT6_acidic PF14632.1 KOO22587.1 - 2.9e-05 24.1 33.7 0.0002 21.4 1.4 6.0 5 1 1 6 6 6 2 Acidic N-terminal SPT6 YqgF PF14639.1 KOO22587.1 - 0.044 13.3 0.1 0.23 10.9 0.0 2.3 1 1 1 2 2 2 0 Holliday-junction resolvase-like of SPT6 Trp_Tyr_perm PF03222.8 KOO22588.1 - 1.1e-13 50.8 15.8 2.9e-13 49.4 10.9 1.6 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family PHY PF00360.15 KOO22588.1 - 0.08 12.0 0.1 0.14 11.3 0.1 1.3 1 0 0 1 1 1 0 Phytochrome region Dicistro_VP4 PF11492.3 KOO22588.1 - 1.7 8.6 8.0 0.8 9.7 0.6 2.8 2 0 0 2 2 2 0 Cricket paralysis virus, VP4 ArgJ PF01960.13 KOO22589.1 - 2.4e-107 358.7 0.0 3.2e-107 358.3 0.0 1.2 1 0 0 1 1 1 1 ArgJ family TIG PF01833.19 KOO22590.1 - 4.9e-10 39.2 0.2 7.8e-10 38.6 0.1 1.3 1 0 0 1 1 1 1 IPT/TIG domain Ank_5 PF13857.1 KOO22590.1 - 1.7e-05 24.8 0.1 4.7e-05 23.4 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO22590.1 - 0.00024 21.3 0.0 0.00055 20.2 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO22590.1 - 0.001 19.5 0.1 0.0028 18.1 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.25 KOO22590.1 - 0.003 17.2 0.2 0.0082 15.9 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.1 KOO22590.1 - 0.0035 17.4 0.1 0.0099 16.0 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeat PBD PF00786.23 KOO22591.1 - 0.049 14.0 0.5 1.5 9.3 0.0 2.9 3 0 0 3 3 3 0 P21-Rho-binding domain CBFD_NFYB_HMF PF00808.18 KOO22593.1 - 2.1e-12 46.9 0.0 3.1e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 KOO22593.1 - 0.0053 16.8 0.0 0.0073 16.4 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Kinesin PF00225.18 KOO22594.1 - 1.1e-117 392.5 0.0 1.1e-117 392.5 0.0 1.7 2 0 0 2 2 2 1 Kinesin motor domain Acyl-CoA_ox_N PF14749.1 KOO22594.1 - 3.4 7.9 14.8 0.25 11.6 4.1 2.7 2 0 0 2 2 2 0 Acyl-coenzyme A oxidase N-terminal HAUS6_N PF14661.1 KOO22594.1 - 5.2 6.3 24.0 8.6 5.6 10.0 2.5 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Corona_S2 PF01601.11 KOO22594.1 - 7.2 4.5 7.7 0.46 8.5 1.1 1.9 2 0 0 2 2 2 0 Coronavirus S2 glycoprotein CTP_transf_3 PF02348.14 KOO22596.1 - 1.8e-44 151.9 0.0 2.4e-44 151.5 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transf_3 PF12804.2 KOO22596.1 - 3.9e-10 40.0 8.0 4.7e-09 36.5 5.6 2.4 1 1 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.14 KOO22596.1 - 1.3e-05 24.8 0.8 2.3e-05 24.0 0.5 1.4 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase QRPTase_C PF01729.14 KOO22596.1 - 0.045 13.2 0.6 0.12 11.8 0.1 1.8 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain Methyltransf_11 PF08241.7 KOO22597.1 - 7.4e-08 32.7 0.0 2.2e-07 31.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO22597.1 - 0.00089 18.4 0.0 0.083 11.9 0.0 2.1 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 KOO22597.1 - 0.0023 18.2 0.0 0.0054 17.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 KOO22597.1 - 0.0056 16.3 0.0 0.61 9.6 0.0 2.1 2 0 0 2 2 2 2 Hypothetical methyltransferase Methyltransf_26 PF13659.1 KOO22597.1 - 0.018 15.0 0.0 0.04 13.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 KOO22597.1 - 0.13 11.8 0.0 0.23 11.0 0.0 1.3 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_26 PF13659.1 KOO22599.1 - 2e-12 47.1 0.2 2.9e-12 46.6 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO22599.1 - 1.5e-07 31.9 0.0 4.2e-07 30.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Spermine_synth PF01564.12 KOO22599.1 - 3.6e-07 29.3 0.0 3.9e-07 29.2 0.0 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_30 PF05430.6 KOO22599.1 - 2.8e-05 23.7 0.0 5.1e-05 22.9 0.0 1.6 2 0 0 2 2 2 1 S-adenosyl-L-methionine-dependent methyltransferase MTS PF05175.9 KOO22599.1 - 0.00029 20.2 0.0 0.00089 18.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.1 KOO22599.1 - 0.0003 20.3 0.0 0.00046 19.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO22599.1 - 0.0043 17.5 0.0 0.01 16.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.1 KOO22599.1 - 0.01 16.6 0.0 0.018 15.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain NHL PF01436.16 KOO22600.1 - 6.2e-09 35.3 0.0 1.2e-05 25.0 0.0 3.5 3 0 0 3 3 3 3 NHL repeat PWWP PF00855.12 KOO22602.1 - 9.6e-13 48.1 0.0 9.6e-13 48.1 0.0 2.6 3 0 0 3 3 3 1 PWWP domain HMG_box PF00505.14 KOO22602.1 - 3.7e-11 43.1 0.9 3.7e-11 43.1 0.6 2.9 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO22602.1 - 9.5e-06 25.8 1.6 9.5e-06 25.8 1.1 3.0 2 1 1 3 3 3 1 HMG-box domain PLRV_ORF5 PF01690.12 KOO22602.1 - 9.9 5.1 9.3 16 4.5 6.5 1.4 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein TauD PF02668.11 KOO22603.1 - 3.5e-31 108.8 0.0 5.8e-31 108.0 0.0 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Leu_Phe_trans PF03588.9 KOO22603.1 - 0.0015 17.6 0.0 0.0026 16.9 0.0 1.3 1 0 0 1 1 1 1 Leucyl/phenylalanyl-tRNA protein transferase Trigger_C PF05698.9 KOO22604.1 - 0.054 13.3 0.6 0.12 12.2 0.1 1.7 1 1 1 2 2 2 0 Bacterial trigger factor protein (TF) C-terminus Pro-kuma_activ PF09286.6 KOO22605.1 - 3.8e-31 108.0 0.0 6.3e-31 107.3 0.0 1.4 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.17 KOO22605.1 - 2.9e-07 29.9 0.7 4.6e-07 29.2 0.5 1.3 1 0 0 1 1 1 1 Subtilase family ABC_tran PF00005.22 KOO22606.1 - 1.7e-29 102.8 0.0 4.5e-14 52.9 0.0 2.6 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 KOO22606.1 - 7.6e-24 85.1 4.5 8.3e-07 29.2 0.0 4.1 4 0 0 4 4 4 4 AAA domain AAA_15 PF13175.1 KOO22606.1 - 8.5e-13 48.1 0.0 0.011 14.8 0.0 4.0 4 0 0 4 4 4 4 AAA ATPase domain SMC_N PF02463.14 KOO22606.1 - 7.4e-09 35.1 3.1 0.0059 15.8 0.3 3.9 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 KOO22606.1 - 7e-08 31.8 0.1 0.0045 16.4 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_17 PF13207.1 KOO22606.1 - 1.3e-06 29.2 0.1 0.00096 19.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.4 KOO22606.1 - 2.1e-06 27.2 0.2 0.056 12.9 0.0 2.7 3 0 0 3 3 2 2 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.1 KOO22606.1 - 9.2e-06 25.1 4.0 0.071 12.5 0.3 3.3 3 1 0 3 3 3 2 AAA domain AAA_23 PF13476.1 KOO22606.1 - 1.9e-05 25.1 0.5 0.14 12.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA PF00004.24 KOO22606.1 - 2.5e-05 24.4 0.8 0.64 10.2 0.0 3.5 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) DUF3584 PF12128.3 KOO22606.1 - 3.5e-05 21.3 2.9 0.015 12.6 0.2 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3584) DUF258 PF03193.11 KOO22606.1 - 4.3e-05 22.7 0.0 0.097 11.8 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Arf PF00025.16 KOO22606.1 - 0.00011 21.5 0.1 0.075 12.2 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family Miro PF08477.8 KOO22606.1 - 0.00026 21.4 0.1 0.67 10.4 0.0 2.3 2 0 0 2 2 2 2 Miro-like protein AAA_28 PF13521.1 KOO22606.1 - 0.00029 20.8 1.7 0.32 10.9 0.0 2.8 3 0 0 3 3 3 2 AAA domain AAA_14 PF13173.1 KOO22606.1 - 0.00053 19.8 0.4 4.1 7.3 0.0 3.6 4 0 0 4 4 4 0 AAA domain AAA_33 PF13671.1 KOO22606.1 - 0.00057 19.7 0.3 0.98 9.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain SRP54 PF00448.17 KOO22606.1 - 0.00067 19.1 2.0 0.42 10.0 0.1 2.3 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain Zeta_toxin PF06414.7 KOO22606.1 - 0.00096 18.3 0.5 0.71 8.9 0.0 2.2 2 0 0 2 2 2 2 Zeta toxin AAA_30 PF13604.1 KOO22606.1 - 0.0013 18.3 1.0 0.79 9.2 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.1 KOO22606.1 - 0.0015 18.6 11.2 1.4 9.0 1.6 4.1 3 1 0 3 3 3 1 AAA domain AAA_5 PF07728.9 KOO22606.1 - 0.0033 17.1 3.1 7.1 6.3 0.0 4.1 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) UPF0079 PF02367.12 KOO22606.1 - 0.0038 16.8 0.3 2 8.0 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 FtsK_SpoIIIE PF01580.13 KOO22606.1 - 0.0041 16.6 0.1 0.26 10.7 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family MobB PF03205.9 KOO22606.1 - 0.005 16.5 0.7 2.6 7.7 0.1 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_13 PF13166.1 KOO22606.1 - 0.006 15.1 0.0 1.7 7.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.1 KOO22606.1 - 0.0091 15.5 1.2 1.9 7.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 KOO22606.1 - 0.0099 15.8 0.1 4.1 7.3 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase cobW PF02492.14 KOO22606.1 - 0.014 14.8 3.3 1.9 7.8 0.3 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_10 PF12846.2 KOO22606.1 - 0.02 14.3 2.1 1.4 8.2 0.0 2.4 2 0 0 2 2 2 0 AAA-like domain Septin PF00735.13 KOO22606.1 - 0.027 13.5 0.1 2.6 6.9 0.0 2.2 2 0 0 2 2 2 0 Septin ATP-synt_ab PF00006.20 KOO22606.1 - 0.032 13.7 0.0 2.7 7.4 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_18 PF13238.1 KOO22606.1 - 0.045 14.0 0.4 2.1 8.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF615 PF04751.9 KOO22606.1 - 0.076 12.6 0.1 7.8 6.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF615) Dynamin_N PF00350.18 KOO22606.1 - 0.099 12.4 0.4 2.5 7.9 0.0 2.3 2 0 0 2 2 2 0 Dynamin family AAA_19 PF13245.1 KOO22606.1 - 0.15 11.8 1.5 14 5.5 0.1 2.7 2 0 0 2 2 2 0 Part of AAA domain RNA_helicase PF00910.17 KOO22606.1 - 0.16 12.1 0.2 14 5.9 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA_16 PF13191.1 KOO22606.1 - 0.16 11.9 13.1 1.6 8.6 2.7 3.5 2 2 0 2 2 2 0 AAA ATPase domain DLIC PF05783.6 KOO22606.1 - 0.25 9.9 0.1 14 4.2 0.0 2.4 3 0 0 3 3 3 0 Dynein light intermediate chain (DLIC) Gtr1_RagA PF04670.7 KOO22606.1 - 0.27 10.3 0.7 3.9 6.5 0.0 2.1 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region NACHT PF05729.7 KOO22606.1 - 1.8 8.1 13.5 0.9 9.1 0.3 3.2 4 1 0 4 4 2 0 NACHT domain HMG_box PF00505.14 KOO22608.1 - 2.2e-16 59.8 0.3 2.2e-16 59.8 0.2 2.6 2 1 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO22608.1 - 1e-11 45.0 0.8 1e-11 45.0 0.6 2.5 2 1 0 2 2 2 1 HMG-box domain Myb_DNA-binding PF00249.26 KOO22608.1 - 2.6e-10 40.1 0.0 5.3e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO22608.1 - 3.6e-06 26.9 0.0 1e-05 25.5 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain SpoVR PF04293.8 KOO22608.1 - 0.6 8.4 4.5 1.4 7.2 3.1 1.5 1 0 0 1 1 1 0 SpoVR like protein Ion_trans_2 PF07885.11 KOO22609.1 - 1.7e-28 98.1 15.7 1.1e-15 57.0 5.0 2.3 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.26 KOO22609.1 - 6e-06 25.6 6.7 0.0072 15.6 0.1 2.5 2 1 1 3 3 3 2 Ion transport protein DUF1356 PF07092.7 KOO22610.1 - 5.2e-08 32.3 3.2 0.00015 21.0 0.2 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1356) DnaJ_CXXCXGXG PF00684.14 KOO22610.1 - 0.0066 16.4 16.3 0.73 9.9 3.5 3.3 2 2 1 3 3 3 3 DnaJ central domain CCDC-167 PF15188.1 KOO22611.1 - 0.16 11.9 0.4 0.23 11.4 0.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 Peptidase_C2 PF00648.16 KOO22612.1 - 2.8e-35 121.7 0.0 4.7e-35 121.0 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease TPR_12 PF13424.1 KOO22612.1 - 0.032 14.1 0.1 0.072 13.0 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOO22612.1 - 0.06 12.9 0.2 0.16 11.6 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.1 KOO22612.1 - 0.089 12.4 0.4 0.18 11.4 0.3 1.5 1 0 0 1 1 1 0 TPR repeat Pkinase PF00069.20 KOO22613.1 - 7.6e-40 136.6 0.0 1.1e-39 136.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22613.1 - 3.5e-38 131.1 0.0 4.9e-38 130.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase LRR_4 PF12799.2 KOO22613.1 - 1.6e-07 30.7 0.1 0.00032 20.2 0.0 3.2 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO22613.1 - 3.1e-06 26.8 0.5 9.4e-06 25.2 0.3 1.8 2 0 0 2 2 2 1 Leucine rich repeat APH PF01636.18 KOO22613.1 - 0.047 13.4 0.0 0.16 11.7 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family LRR_1 PF00560.28 KOO22613.1 - 0.14 12.2 3.9 8.4 6.8 0.1 3.7 3 0 0 3 3 3 0 Leucine Rich Repeat Mrr_cat PF04471.7 KOO22614.1 - 3e-17 62.4 0.0 1.5e-16 60.2 0.0 2.0 2 0 0 2 2 2 1 Restriction endonuclease IncA PF04156.9 KOO22614.1 - 0.041 13.4 12.5 0.083 12.4 8.6 1.4 1 0 0 1 1 1 0 IncA protein Spc7 PF08317.6 KOO22614.1 - 0.21 10.1 4.5 0.37 9.3 3.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4200 PF13863.1 KOO22614.1 - 2.9 7.8 18.0 19 5.2 8.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF3584 PF12128.3 KOO22614.1 - 6.3 3.9 16.5 9.3 3.4 11.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) SprT-like PF10263.4 KOO22615.1 - 2.9e-17 62.7 1.7 3.9e-17 62.3 1.2 1.2 1 0 0 1 1 1 1 SprT-like family Zn-ribbon_8 PF09723.5 KOO22615.1 - 8.6e-05 22.4 3.4 0.0002 21.2 2.3 1.5 1 0 0 1 1 1 1 Zinc ribbon domain HMG_box PF00505.14 KOO22615.1 - 0.00022 21.4 0.0 0.00041 20.5 0.0 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO22615.1 - 0.016 15.5 0.0 0.025 14.9 0.0 1.3 1 0 0 1 1 1 0 HMG-box domain DUF2072 PF09845.4 KOO22615.1 - 0.06 13.2 0.4 0.077 12.9 0.3 1.2 1 0 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) zf-H2C2_2 PF13465.1 KOO22615.1 - 6.9 7.1 7.2 1.2 9.5 0.8 2.2 1 1 1 2 2 2 0 Zinc-finger double domain NAD_binding_1 PF00175.16 KOO22616.1 - 2.3e-29 102.1 0.0 4.1e-29 101.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 KOO22616.1 - 1.4e-23 82.9 0.0 5e-21 74.6 0.0 2.4 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain FAD_binding_9 PF08021.6 KOO22616.1 - 8.3e-07 28.9 0.0 1.3e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Siderophore-interacting FAD-binding domain NAD_binding_6 PF08030.7 KOO22616.1 - 0.00022 21.1 0.0 0.014 15.3 0.0 2.3 2 0 0 2 2 2 1 Ferric reductase NAD binding domain PX PF00787.19 KOO22617.1 - 1.4e-14 53.8 0.0 2.2e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 PX domain CUE PF02845.11 KOO22617.1 - 0.015 14.7 0.7 0.028 13.9 0.0 1.9 2 0 0 2 2 2 0 CUE domain Helicase_C PF00271.26 KOO22618.1 - 5.6e-11 42.1 0.0 1.1e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain INCENP_ARK-bind PF03941.10 KOO22618.1 - 9.2 6.1 11.1 0.21 11.4 0.7 2.8 2 1 1 3 3 3 0 Inner centromere protein, ARK binding region DEAD PF00270.24 KOO22619.1 - 2.8e-24 85.5 0.1 3.8e-24 85.0 0.1 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 KOO22619.1 - 9.4e-06 25.5 0.0 0.00047 20.0 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 KOO22619.1 - 0.09 12.9 0.3 0.74 9.9 0.2 2.2 1 1 0 1 1 1 0 AAA domain SecA_DEAD PF07517.9 KOO22619.1 - 0.2 10.9 0.4 8.2 5.6 0.0 2.5 2 1 1 3 3 3 0 SecA DEAD-like domain EF-hand_1 PF00036.27 KOO22620.1 - 8.9e-10 37.1 0.2 5.2e-05 22.2 0.0 3.1 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO22620.1 - 1e-07 31.9 0.5 3.3e-07 30.3 0.4 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO22620.1 - 1.3e-07 31.0 0.8 2.3e-06 27.1 0.1 2.6 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO22620.1 - 3.4e-07 29.3 0.2 0.0022 17.2 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO22620.1 - 1.1e-05 24.8 0.1 0.28 11.1 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain Peptidase_C1 PF00112.18 KOO22621.1 - 4.7e-50 170.4 8.1 9.5e-50 169.4 5.6 1.5 1 1 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KOO22621.1 - 1.7e-08 34.5 1.0 2.6e-08 33.9 0.7 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.10 KOO22621.1 - 0.0082 14.7 1.1 0.8 8.1 0.0 2.6 3 0 0 3 3 3 2 Peptidase C1-like family PFEMP PF03011.10 KOO22621.1 - 0.19 12.0 1.8 0.33 11.2 1.3 1.3 1 0 0 1 1 1 0 PFEMP DBL domain Acyl-CoA_dh_1 PF00441.19 KOO22622.1 - 5.6e-52 175.8 2.2 1.1e-51 174.9 1.5 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 KOO22622.1 - 6.9e-26 91.0 0.7 2.9e-25 89.0 0.1 2.5 3 0 0 3 3 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 KOO22622.1 - 8.5e-22 76.4 0.9 1.8e-21 75.3 0.6 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 KOO22622.1 - 5.3e-21 75.2 1.9 1.3e-20 74.0 1.3 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Amino_oxidase PF01593.19 KOO22622.1 - 3.6e-17 62.5 0.7 3.1e-16 59.5 0.5 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 KOO22622.1 - 3.1e-14 52.7 0.5 1.8e-13 50.3 0.5 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOO22622.1 - 6.6e-11 41.7 4.6 1.8e-09 36.9 3.2 2.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 KOO22622.1 - 1.9e-10 40.9 0.0 8.3e-06 25.8 0.1 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 KOO22622.1 - 4.9e-07 28.5 1.4 0.013 13.9 0.4 2.7 3 0 0 3 3 3 2 HI0933-like protein NAD_binding_9 PF13454.1 KOO22622.1 - 2.7e-05 24.0 1.2 0.27 11.0 0.2 2.7 3 0 0 3 3 3 2 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 KOO22622.1 - 0.00017 21.7 0.4 0.0045 17.0 0.5 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 KOO22622.1 - 0.00032 19.9 0.1 0.0011 18.1 0.1 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.12 KOO22622.1 - 0.00092 18.3 0.3 0.0021 17.1 0.2 1.5 1 0 0 1 1 1 1 Thi4 family HpaB_N PF11794.3 KOO22622.1 - 0.0016 17.8 0.2 0.0041 16.5 0.1 1.5 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal FAD_binding_2 PF00890.19 KOO22622.1 - 0.0017 17.2 2.0 0.0017 17.2 1.4 1.7 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.17 KOO22622.1 - 0.0024 16.7 1.2 0.035 12.9 0.7 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox PF00070.22 KOO22622.1 - 0.0024 18.2 0.0 0.046 14.1 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 KOO22622.1 - 0.003 16.6 1.8 0.0059 15.7 0.6 1.9 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.7 KOO22622.1 - 0.0037 16.2 2.6 0.0044 15.9 0.3 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein 3HCDH_N PF02737.13 KOO22622.1 - 0.098 12.3 0.3 0.18 11.4 0.2 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Dev_Cell_Death PF10539.4 KOO22623.1 - 9e-28 96.4 0.0 2.2e-27 95.1 0.0 1.7 1 1 0 1 1 1 1 Development and cell death domain HMG_box PF00505.14 KOO22623.1 - 7.3e-06 26.1 1.1 1.4e-05 25.2 0.8 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO22623.1 - 0.0051 17.1 1.0 0.013 15.8 0.7 1.7 1 0 0 1 1 1 1 HMG-box domain G6PD_C PF02781.11 KOO22624.1 - 3.2e-85 285.5 0.0 4e-85 285.2 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.17 KOO22624.1 - 4.9e-48 163.7 0.0 7.8e-48 163.1 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain EF-hand_1 PF00036.27 KOO22624.1 - 3.3e-07 29.1 0.1 3.8e-06 25.8 0.1 2.7 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO22624.1 - 4.1e-07 29.3 0.3 2e-05 24.1 0.1 3.1 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.1 KOO22624.1 - 1.1e-06 28.6 0.3 5.3e-06 26.4 0.2 2.1 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO22624.1 - 2.3e-05 23.5 0.1 6.9e-05 22.0 0.1 1.8 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 KOO22624.1 - 0.0021 17.6 0.3 0.0091 15.5 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain pair MutS_V PF00488.16 KOO22625.1 - 7.4e-50 169.5 0.0 6.7e-49 166.4 0.0 2.2 1 1 0 1 1 1 1 MutS domain V MutS_III PF05192.13 KOO22625.1 - 1.6e-24 86.8 0.1 8.9e-24 84.4 0.0 2.2 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.13 KOO22625.1 - 0.013 15.6 0.0 0.031 14.4 0.0 1.6 1 0 0 1 1 1 0 MutS family domain IV AAA_21 PF13304.1 KOO22625.1 - 0.041 13.8 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 KOO22625.1 - 0.049 13.5 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 KOO22625.1 - 0.072 13.4 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 KOO22625.1 - 0.12 12.0 0.0 18 4.9 0.0 2.3 2 0 0 2 2 2 0 Archaeal ATPase AAA_22 PF13401.1 KOO22625.1 - 0.18 11.9 0.0 0.62 10.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain Glyco_transf_34 PF05637.7 KOO22626.1 - 8e-14 51.7 0.1 1.6e-08 34.3 0.1 2.1 1 1 0 2 2 2 2 galactosyl transferase GMA12/MNN10 family Pkinase PF00069.20 KOO22627.1 - 1e-56 192.0 0.0 1.3e-56 191.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22627.1 - 3.6e-40 137.6 0.0 5.3e-40 137.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO22627.1 - 1.1e-05 24.5 0.0 2.3e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Kinase-like VHP PF02209.14 KOO22627.1 - 3.5e-05 23.3 0.0 6.5e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Villin headpiece domain LRR_4 PF12799.2 KOO22627.1 - 0.041 13.5 1.5 13 5.5 0.0 4.1 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO22627.1 - 0.14 12.3 2.1 5.1 7.4 0.0 4.6 6 0 0 6 6 6 0 Leucine Rich repeat ADPrib_exo_Tox PF03496.9 KOO22628.1 - 9.3e-06 24.9 0.0 7.8e-05 21.9 0.0 2.1 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme ART PF01129.13 KOO22628.1 - 4.1e-05 22.7 0.0 0.0004 19.5 0.0 2.2 1 1 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Pox_A_type_inc PF04508.7 KOO22629.1 - 0.18 11.6 0.1 0.18 11.6 0.1 2.9 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat FUSC PF04632.7 KOO22629.1 - 0.23 9.8 14.0 0.27 9.6 9.7 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family IncA PF04156.9 KOO22629.1 - 0.49 9.9 14.3 0.77 9.3 9.9 1.2 1 0 0 1 1 1 0 IncA protein UIM PF02809.15 KOO22630.1 - 0.022 14.2 7.4 0.038 13.5 5.2 1.4 1 0 0 1 1 1 0 Ubiquitin interaction motif HSP70 PF00012.15 KOO22631.1 - 2.5e-265 881.1 8.4 2.5e-265 881.1 5.8 2.5 3 0 0 3 3 2 1 Hsp70 protein AAA PF00004.24 KOO22631.1 - 8e-93 307.5 0.0 2.5e-46 157.1 0.0 3.3 4 0 0 4 4 2 2 ATPase family associated with various cellular activities (AAA) PGM_PMM_I PF02878.11 KOO22631.1 - 7.7e-18 64.2 0.1 9.4e-08 31.6 0.0 2.9 2 0 0 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I MreB_Mbl PF06723.8 KOO22631.1 - 1.6e-12 46.6 0.1 7.5e-12 44.4 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein RuvB_N PF05496.7 KOO22631.1 - 2e-12 46.6 0.0 3.2e-05 23.0 0.0 3.0 3 0 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 KOO22631.1 - 1.3e-11 44.5 4.3 5.9e-06 26.2 0.0 4.0 4 0 0 4 4 2 2 AAA domain CDC48_N PF02359.13 KOO22631.1 - 2.7e-11 43.2 0.0 1.1e-10 41.2 0.0 2.2 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_17 PF13207.1 KOO22631.1 - 4.7e-11 43.5 0.2 0.00017 22.3 0.0 3.4 3 0 0 3 3 2 2 AAA domain PGM_PMM_IV PF00408.15 KOO22631.1 - 9.8e-11 41.5 0.5 7.5e-10 38.6 0.1 2.8 2 0 0 2 2 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain AAA_2 PF07724.9 KOO22631.1 - 2.3e-10 40.6 0.0 0.00093 19.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 KOO22631.1 - 5.8e-10 39.4 0.2 0.0094 16.0 0.0 4.7 2 2 0 2 2 2 2 AAA domain AAA_5 PF07728.9 KOO22631.1 - 2.9e-09 36.7 0.0 0.00081 19.1 0.0 3.4 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 KOO22631.1 - 4.1e-09 36.3 0.0 0.0021 17.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.7 KOO22631.1 - 5.8e-08 32.0 0.0 0.0073 15.4 0.0 2.9 2 0 0 2 2 2 2 Zeta toxin TIP49 PF06068.8 KOO22631.1 - 2.1e-07 29.9 0.0 0.0044 15.8 0.0 2.5 2 0 0 2 2 2 2 TIP49 C-terminus RNA_helicase PF00910.17 KOO22631.1 - 3.3e-07 30.4 0.0 0.014 15.5 0.0 3.1 3 0 0 3 3 2 2 RNA helicase IstB_IS21 PF01695.12 KOO22631.1 - 3.6e-07 29.7 0.0 0.011 15.1 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_28 PF13521.1 KOO22631.1 - 6e-07 29.5 0.5 0.02 14.8 0.0 3.6 3 0 0 3 3 2 2 AAA domain Viral_helicase1 PF01443.13 KOO22631.1 - 1.1e-06 28.3 0.0 0.01 15.4 0.0 2.6 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.1 KOO22631.1 - 1.3e-06 28.5 0.0 0.00032 20.7 0.0 6.0 4 2 1 5 5 3 2 AAA ATPase domain PGM_PMM_III PF02880.11 KOO22631.1 - 2.6e-06 27.4 1.3 4.4e-06 26.7 0.1 2.1 2 0 0 2 2 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III NACHT PF05729.7 KOO22631.1 - 2.9e-06 27.0 1.0 0.36 10.4 0.1 4.1 5 0 0 5 5 3 2 NACHT domain Mg_chelatase PF01078.16 KOO22631.1 - 2.9e-06 26.5 0.5 0.077 12.1 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI ABC_tran PF00005.22 KOO22631.1 - 3.4e-06 27.3 1.2 0.12 12.6 0.0 4.1 3 0 0 3 3 3 2 ABC transporter AAA_18 PF13238.1 KOO22631.1 - 3.5e-06 27.3 0.0 0.16 12.3 0.0 3.1 2 0 0 2 2 2 2 AAA domain Molydop_binding PF01568.16 KOO22631.1 - 4.9e-06 26.3 0.1 0.00017 21.3 0.0 2.6 2 0 0 2 2 2 1 Molydopterin dinucleotide binding domain PGM_PMM_II PF02879.11 KOO22631.1 - 1.5e-05 25.2 0.0 0.00021 21.5 0.0 3.0 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Sigma54_activ_2 PF14532.1 KOO22631.1 - 5.3e-05 23.2 0.0 0.34 10.9 0.0 2.8 2 0 0 2 2 2 2 Sigma-54 interaction domain NB-ARC PF00931.17 KOO22631.1 - 0.00012 20.9 0.0 0.32 9.7 0.0 2.6 2 0 0 2 2 2 2 NB-ARC domain AAA_25 PF13481.1 KOO22631.1 - 0.00025 20.5 9.6 0.84 9.0 0.0 5.4 3 2 2 5 5 5 2 AAA domain Bac_DnaA PF00308.13 KOO22631.1 - 0.00028 20.5 0.0 1.2 8.7 0.0 2.7 2 0 0 2 2 2 2 Bacterial dnaA protein ResIII PF04851.10 KOO22631.1 - 0.00032 20.5 0.5 0.15 11.8 0.0 3.1 3 0 0 3 3 2 1 Type III restriction enzyme, res subunit Parvo_NS1 PF01057.12 KOO22631.1 - 0.00036 19.4 0.3 0.11 11.3 0.0 2.4 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 Arch_ATPase PF01637.13 KOO22631.1 - 0.0006 19.5 2.3 1.5 8.4 0.0 4.2 3 2 1 4 4 4 1 Archaeal ATPase AAA_19 PF13245.1 KOO22631.1 - 0.00079 19.1 12.3 0.03 14.0 0.1 4.3 4 0 0 4 4 3 2 Part of AAA domain Cytidylate_kin2 PF13189.1 KOO22631.1 - 0.00096 19.1 2.5 0.53 10.1 0.0 3.4 3 0 0 3 3 2 1 Cytidylate kinase-like family PhoH PF02562.11 KOO22631.1 - 0.0011 18.2 0.3 2 7.5 0.0 3.1 3 0 0 3 3 3 1 PhoH-like protein Reo_sigmaC PF04582.7 KOO22631.1 - 0.0016 17.6 8.5 0.0021 17.3 1.2 2.8 2 1 0 2 2 2 1 Reovirus sigma C capsid protein Sigma54_activat PF00158.21 KOO22631.1 - 0.0018 17.7 0.0 2.5 7.5 0.0 2.8 2 1 0 2 2 2 1 Sigma-54 interaction domain ATP-synt_ab PF00006.20 KOO22631.1 - 0.0021 17.6 0.0 2.1 7.7 0.0 3.1 2 1 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_3 PF07726.6 KOO22631.1 - 0.0023 17.5 0.0 2.6 7.6 0.0 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) KaiC PF06745.8 KOO22631.1 - 0.0025 16.9 0.0 3.8 6.5 0.0 3.3 3 0 0 3 3 3 0 KaiC AAA_24 PF13479.1 KOO22631.1 - 0.003 17.1 0.2 1 8.8 0.0 2.8 3 0 0 3 3 2 1 AAA domain Rad17 PF03215.10 KOO22631.1 - 0.005 15.5 0.0 0.89 8.1 0.0 2.3 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein Vps4_C PF09336.5 KOO22631.1 - 0.0051 16.6 1.8 0.04 13.8 0.0 3.0 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain NTPase_1 PF03266.10 KOO22631.1 - 0.016 14.8 0.0 2.8 7.6 0.0 2.9 2 0 0 2 2 2 0 NTPase AAA_23 PF13476.1 KOO22631.1 - 3.5 7.8 21.8 4.5 7.5 0.0 4.8 6 0 0 6 6 4 0 AAA domain Baculo_PEP_C PF04513.7 KOO22631.1 - 7.7 6.3 15.1 0.82 9.4 2.2 4.0 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Beta_helix PF13229.1 KOO22632.1 - 0.00029 20.6 0.0 0.029 14.1 0.0 2.3 1 1 1 2 2 2 2 Right handed beta helix region Neuroparsin PF07327.6 KOO22632.1 - 0.034 14.3 0.1 0.11 12.7 0.1 1.8 1 0 0 1 1 1 0 Neuroparsin UCH PF00443.24 KOO22633.1 - 8.3e-35 120.1 0.0 1.1e-34 119.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOO22633.1 - 2e-12 47.2 0.0 2.5e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Zn-ribbon_8 PF09723.5 KOO22633.1 - 0.013 15.4 1.7 0.26 11.2 0.3 2.5 2 0 0 2 2 2 0 Zinc ribbon domain DUF3371 PF11851.3 KOO22634.1 - 0.073 13.7 3.0 0.055 14.1 1.0 1.7 2 1 0 2 2 2 0 Domain of unknown function (DUF3371) GvpK PF05121.7 KOO22634.1 - 0.087 12.6 3.8 0.59 9.9 2.7 2.2 1 1 0 1 1 1 0 Gas vesicle protein K V_ATPase_I PF01496.14 KOO22634.1 - 0.097 10.5 1.7 0.12 10.2 1.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GLE1 PF07817.8 KOO22634.1 - 0.1 11.5 0.5 0.15 10.9 0.4 1.2 1 0 0 1 1 1 0 GLE1-like protein SlyX PF04102.7 KOO22634.1 - 2.5 8.5 9.9 5.6 7.4 0.3 2.9 2 1 1 3 3 3 0 SlyX ACBP PF00887.14 KOO22635.1 - 0.19 11.4 0.2 1.9 8.1 0.0 2.5 3 0 0 3 3 3 0 Acyl CoA binding protein ubiquitin PF00240.18 KOO22636.1 - 1.4e-06 27.5 0.0 3.2e-05 23.2 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin family zf-AN1 PF01428.11 KOO22636.1 - 0.00021 21.0 6.9 0.00052 19.8 4.8 1.6 1 0 0 1 1 1 1 AN1-like Zinc finger Rad60-SLD PF11976.3 KOO22636.1 - 0.0081 15.8 0.0 0.37 10.5 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ribosomal_L18ae PF01775.12 KOO22638.1 - 4.1e-46 155.9 3.1 4.1e-46 155.9 2.2 1.7 2 0 0 2 2 2 1 Ribosomal L18ae/LX protein domain Bundlin PF05307.6 KOO22638.1 - 0.017 14.9 0.0 0.038 13.8 0.0 1.6 1 0 0 1 1 1 0 Bundlin Ferrochelatase PF00762.14 KOO22639.1 - 1.5e-87 293.5 0.0 2.3e-87 292.9 0.0 1.3 1 0 0 1 1 1 1 Ferrochelatase Rieske PF00355.21 KOO22639.1 - 2.3e-11 43.0 0.0 4.5e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.1 KOO22639.1 - 5.3e-06 26.0 0.0 1.1e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Chloroa_b-bind PF00504.16 KOO22639.1 - 0.0016 18.7 0.0 0.0031 17.8 0.0 1.5 1 0 0 1 1 1 1 Chlorophyll A-B binding protein CbiX PF01903.12 KOO22639.1 - 0.057 13.5 0.0 5.6 7.1 0.0 2.7 2 0 0 2 2 2 0 CbiX NUDIX PF00293.23 KOO22643.1 - 4.3e-14 52.3 0.6 7.3e-14 51.5 0.4 1.3 1 0 0 1 1 1 1 NUDIX domain zf-NADH-PPase PF09297.6 KOO22643.1 - 3.2e-05 23.3 4.8 3.2e-05 23.3 3.3 2.2 2 0 0 2 2 2 1 NADH pyrophosphatase zinc ribbon domain OrfB_Zn_ribbon PF07282.6 KOO22643.1 - 0.012 15.2 2.2 0.025 14.2 1.5 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Zn_Tnp_IS91 PF14319.1 KOO22643.1 - 0.084 12.3 0.7 0.19 11.2 0.5 1.5 1 0 0 1 1 1 0 Transposase zinc-binding domain GRIP PF01465.15 KOO22645.1 - 5.6e-13 48.1 0.2 9.2e-13 47.4 0.2 1.4 1 0 0 1 1 1 1 GRIP domain ACCA PF03255.9 KOO22645.1 - 0.058 12.9 0.1 0.075 12.5 0.0 1.2 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit PPP1R35_C PF15503.1 KOO22645.1 - 0.085 12.3 0.2 0.085 12.3 0.1 1.8 2 1 0 2 2 2 0 Protein phosphatase 1 regulatory subunit 35 C-terminus tRNA_edit PF04073.10 KOO22648.1 - 9.4e-26 90.0 0.1 1.9e-25 89.0 0.1 1.5 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain HGTP_anticodon PF03129.15 KOO22648.1 - 2.8e-20 72.0 0.0 6.4e-20 70.8 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain ProRS-C_1 PF09180.6 KOO22648.1 - 5.3e-18 64.6 0.3 2e-17 62.8 0.2 2.1 1 1 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.20 KOO22648.1 - 2.4e-16 59.7 0.0 4.3e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Sel1 PF08238.7 KOO22649.1 - 2.1e-53 177.5 59.6 2.2e-09 37.6 0.3 8.9 9 0 0 9 9 9 7 Sel1 repeat Toxin-JAB1 PF15659.1 KOO22649.1 - 0.016 15.0 1.0 43 3.9 0.0 4.7 5 1 1 6 6 6 0 JAB-like toxin 1 GSP_synth PF03738.9 KOO22649.1 - 0.019 15.1 0.4 46 4.3 0.0 3.7 2 1 0 3 3 3 0 Glutathionylspermidine synthase preATP-grasp YrzO PF14142.1 KOO22649.1 - 0.12 12.0 0.5 21 4.8 0.0 3.7 4 0 0 4 4 4 0 YrzO-like protein YjbE PF11106.3 KOO22649.1 - 0.27 11.2 8.1 1.5 8.8 2.7 2.5 2 0 0 2 2 2 0 Exopolysaccharide production protein YjbE AdoMet_dc PF02675.10 KOO22650.1 - 0.07 13.0 0.3 0.14 12.0 0.2 1.4 1 0 0 1 1 1 0 S-adenosylmethionine decarboxylase TPR_11 PF13414.1 KOO22651.1 - 1.7e-12 46.7 3.9 3.4e-12 45.8 2.7 1.5 1 0 0 1 1 1 1 TPR repeat TPR_1 PF00515.23 KOO22651.1 - 2.7e-08 33.0 2.8 0.0073 15.8 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO22651.1 - 1.1e-05 25.0 3.8 0.053 13.4 2.2 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO22651.1 - 0.0023 17.8 4.4 0.13 12.2 1.1 2.3 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO22651.1 - 0.012 16.2 3.0 0.035 14.8 1.8 2.0 1 1 0 1 1 1 0 Tetratricopeptide repeat DUF2239 PF09998.4 KOO22651.1 - 0.03 13.9 0.2 0.059 12.9 0.1 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2239) TPR_9 PF13371.1 KOO22651.1 - 0.059 13.2 3.4 0.39 10.5 1.8 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO22651.1 - 0.078 12.8 1.8 0.58 10.1 0.8 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO22651.1 - 0.2 12.3 6.3 5.6 7.8 0.9 2.9 1 1 1 2 2 2 0 Tetratricopeptide repeat Methyltransf_23 PF13489.1 KOO22652.1 - 1.4e-13 50.8 0.0 1.9e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO22652.1 - 6.7e-10 38.7 0.0 9e-10 38.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO22652.1 - 2.4e-09 36.6 0.0 3.2e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 KOO22652.1 - 2.2e-08 34.4 0.0 3.4e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO22652.1 - 7.1e-08 33.0 0.0 1.3e-07 32.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO22652.1 - 8.9e-08 32.5 0.0 1.5e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO22652.1 - 4.5e-06 26.9 0.0 7.7e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO22652.1 - 0.00012 22.1 0.0 0.00026 21.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PTS_IIA PF02255.11 KOO22652.1 - 0.18 11.6 0.5 0.32 10.8 0.4 1.3 1 0 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIA subunit SBBP PF06739.6 KOO22654.1 - 3.9e-16 58.5 89.1 0.0032 17.2 0.4 12.5 13 0 0 13 13 13 9 Beta-propeller repeat DUF3712 PF12505.3 KOO22654.1 - 6.6e-05 22.9 0.8 14 5.7 0.0 7.2 9 0 0 9 9 9 1 Protein of unknown function (DUF3712) DUF4357 PF14267.1 KOO22654.1 - 0.012 15.1 7.5 0.57 9.8 0.2 6.3 10 0 0 10 10 10 0 Domain of unknown function (DUF4357) V-SNARE PF05008.10 KOO22654.1 - 0.19 11.9 2.1 0.44 10.7 1.5 1.5 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus Filament PF00038.16 KOO22654.1 - 0.57 9.5 14.3 3.9 6.8 9.5 2.0 1 1 0 1 1 1 0 Intermediate filament protein Fib_alpha PF08702.5 KOO22654.1 - 1.6 8.8 2.0 3.1 7.9 1.4 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family CENP-F_leu_zip PF10473.4 KOO22654.1 - 2 8.2 13.5 0.64 9.8 7.5 1.5 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MAT1 PF06391.8 KOO22654.1 - 2.1 7.9 6.5 3.1 7.3 4.5 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Pox_A_type_inc PF04508.7 KOO22654.1 - 3.7 7.5 6.9 9.8 6.2 1.6 2.6 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat DUF3391 PF11871.3 KOO22654.1 - 7.9 6.7 7.8 1.7 8.8 2.3 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3391) Fer2_4 PF13510.1 KOO22655.1 - 0.03 14.1 0.1 6.5 6.6 0.0 2.3 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Metallophos_2 PF12850.2 KOO22655.1 - 0.11 12.3 0.0 3.5 7.4 0.0 1.9 1 1 1 2 2 2 0 Calcineurin-like phosphoesterase superfamily domain LRR_6 PF13516.1 KOO22656.1 - 9.5e-45 145.6 9.2 0.00053 19.7 0.0 12.3 11 1 0 11 11 11 11 Leucine Rich repeat PhzC-PhzF PF02567.11 KOO22656.1 - 7.1e-31 107.4 0.2 1.3e-30 106.6 0.1 1.3 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein LRR_4 PF12799.2 KOO22656.1 - 5.5e-07 29.0 3.6 2.5 7.7 0.1 6.3 5 2 1 7 7 7 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO22656.1 - 1.3e-05 24.5 0.0 4.1 7.8 0.0 6.5 8 0 0 8 8 8 1 Leucine Rich Repeat LRR_8 PF13855.1 KOO22656.1 - 0.0016 18.1 0.7 37 4.1 0.0 5.1 4 2 0 4 4 4 0 Leucine rich repeat LRR_7 PF13504.1 KOO22656.1 - 0.14 12.4 7.7 29 5.4 0.0 6.5 8 0 0 8 8 8 0 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO22656.1 - 0.15 12.2 5.1 20 5.4 0.2 4.8 2 1 1 4 4 4 0 RNA 2'-O ribose methyltransferase substrate binding CbiG_N PF11760.3 KOO22656.1 - 1.2 8.8 28.4 9.2 6.0 0.3 7.9 7 2 2 9 9 9 0 Cobalamin synthesis G N-terminal DivIVA PF05103.8 KOO22657.1 - 0.037 14.0 0.7 0.043 13.8 0.5 1.1 1 0 0 1 1 1 0 DivIVA protein Cytochrom_B562 PF07361.6 KOO22657.1 - 0.066 13.6 0.4 0.093 13.1 0.3 1.3 1 0 0 1 1 1 0 Cytochrome b562 DUF4139 PF13598.1 KOO22657.1 - 0.26 10.5 2.9 0.29 10.3 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4139) PH PF00169.24 KOO22658.1 - 2.7e-17 62.8 0.0 6.3e-08 32.7 0.0 2.3 2 0 0 2 2 2 2 PH domain PH_11 PF15413.1 KOO22658.1 - 3.6e-08 33.6 0.1 0.00089 19.4 0.0 3.1 2 1 0 2 2 2 2 Pleckstrin homology domain Mito_carr PF00153.22 KOO22659.1 - 4e-12 45.6 6.4 0.00019 21.0 0.3 4.7 3 3 0 3 3 3 3 Mitochondrial carrier protein Nucleo_LEF-12 PF06256.6 KOO22660.1 - 0.23 11.1 1.0 0.36 10.5 0.7 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus LEF-12 protein Annexin PF00191.15 KOO22661.1 - 8.9e-55 182.4 0.1 3.7e-10 39.5 0.1 8.4 7 1 2 9 9 9 7 Annexin RUN PF02759.14 KOO22661.1 - 0.045 13.5 0.3 0.29 10.8 0.0 2.3 2 0 0 2 2 2 0 RUN domain Ion_trans PF00520.26 KOO22662.1 - 5.6e-12 45.3 10.0 8.4e-12 44.7 6.3 1.9 2 1 0 2 2 2 1 Ion transport protein DUF4131 PF13567.1 KOO22662.1 - 0.094 12.1 6.1 0.2 11.0 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF3816 PF12822.2 KOO22662.1 - 0.12 12.2 6.3 0.16 11.8 1.5 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3816) DUF4355 PF14265.1 KOO22663.1 - 0.064 13.2 7.5 0.31 11.0 2.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) Alginate_lyase PF05426.7 KOO22664.1 - 0.079 12.3 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Alginate lyase Homeobox PF00046.24 KOO22665.1 - 3.3e-18 65.0 1.4 4.9e-18 64.4 0.9 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 KOO22665.1 - 0.0002 20.9 0.2 0.00038 20.0 0.1 1.4 1 0 0 1 1 1 1 Homeobox KN domain DUF4611 PF15387.1 KOO22665.1 - 0.025 14.6 0.1 0.039 14.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Homez PF11569.3 KOO22665.1 - 0.084 11.9 0.1 0.16 11.0 0.1 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez PALP PF00291.20 KOO22666.1 - 8.7e-11 41.5 0.0 3.3e-10 39.7 0.0 1.8 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme MtrG PF04210.8 KOO22667.1 - 0.023 14.3 0.6 0.18 11.4 0.0 2.3 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G ATG16 PF08614.6 KOO22667.1 - 0.065 13.0 11.2 0.027 14.2 4.8 1.9 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) EMP24_GP25L PF01105.19 KOO22667.1 - 0.1 12.3 3.7 1.9 8.1 0.7 2.1 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD HAUS6_N PF14661.1 KOO22667.1 - 0.52 9.6 9.8 5.3 6.3 0.1 2.0 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus TMCO5 PF14992.1 KOO22667.1 - 1.4 7.9 5.9 1.9 7.5 0.1 2.1 2 0 0 2 2 2 0 TMCO5 family Nop25 PF09805.4 KOO22667.1 - 1.5 8.9 9.1 3.2 7.8 6.3 1.5 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) GrpE PF01025.14 KOO22667.1 - 1.5 8.3 8.9 6.3 6.3 0.1 2.1 2 0 0 2 2 2 0 GrpE Gelsolin PF00626.17 KOO22668.1 - 1.5e-29 101.5 0.0 2.1e-12 46.5 0.0 3.3 3 0 0 3 3 3 3 Gelsolin repeat Cation_efflux PF01545.16 KOO22668.1 - 7.6e-09 35.0 0.0 1.1e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Cation efflux family IQ PF00612.22 KOO22668.1 - 0.17 11.6 0.6 0.39 10.4 0.0 2.0 2 0 0 2 2 2 0 IQ calmodulin-binding motif Aminotran_4 PF01063.14 KOO22669.1 - 5.2e-25 88.2 0.0 6.5e-25 87.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class IV Filamin PF00630.14 KOO22670.1 - 4.4e-31 107.4 0.7 1.9e-06 28.3 0.0 5.3 5 0 0 5 5 5 5 Filamin/ABP280 repeat Big_3_4 PF13754.1 KOO22670.1 - 0.041 14.2 5.0 5.6 7.3 0.1 3.5 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 3) DnaJ PF00226.26 KOO22671.1 - 5.3e-19 67.7 0.1 1e-18 66.7 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Kinesin PF00225.18 KOO22672.1 - 3.9e-45 154.0 0.0 2.5e-24 85.6 0.0 2.3 2 1 0 2 2 2 2 Kinesin motor domain SAM_2 PF07647.12 KOO22672.1 - 0.0012 18.6 0.0 0.0025 17.6 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF87 PF01935.12 KOO22672.1 - 0.0031 17.3 0.0 0.0077 16.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function DUF87 AAA_16 PF13191.1 KOO22672.1 - 0.027 14.4 1.0 0.065 13.2 0.1 2.1 2 0 0 2 2 2 0 AAA ATPase domain SAM_PNT PF02198.11 KOO22672.1 - 0.04 13.6 0.0 0.086 12.6 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain AAA_22 PF13401.1 KOO22672.1 - 0.053 13.6 0.0 0.22 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain ResIII PF04851.10 KOO22672.1 - 0.2 11.4 0.0 0.4 10.4 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DUF1471 PF07338.8 KOO22672.1 - 0.28 10.8 4.7 0.71 9.5 3.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1471) AHH PF14412.1 KOO22673.1 - 0.011 15.7 5.5 0.32 10.9 0.2 3.8 2 0 0 2 2 2 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH PhaP_Bmeg PF09602.5 KOO22674.1 - 0.0095 15.7 6.5 0.014 15.2 4.4 1.3 1 1 0 1 1 1 1 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF4466 PF14725.1 KOO22674.1 - 0.028 13.7 0.1 0.03 13.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4466) DUF948 PF06103.6 KOO22674.1 - 0.038 13.8 2.0 0.11 12.3 0.2 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF2853 PF11015.3 KOO22674.1 - 0.049 14.1 0.4 0.18 12.2 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2853) Fez1 PF06818.10 KOO22674.1 - 0.05 13.6 9.0 0.079 12.9 6.2 1.3 1 0 0 1 1 1 0 Fez1 TMEM220 PF15071.1 KOO22674.1 - 0.059 13.8 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 Transmembrane family 220, helix YgaB PF14182.1 KOO22674.1 - 0.097 12.9 0.5 0.097 12.9 0.4 2.6 1 1 1 2 2 2 0 YgaB-like protein Exonuc_VII_L PF02601.10 KOO22674.1 - 0.34 10.0 5.2 0.44 9.7 3.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Med28 PF11594.3 KOO22674.1 - 0.48 10.6 4.6 0.67 10.2 3.2 1.3 1 0 0 1 1 1 0 Mediator complex subunit 28 Tropomyosin PF00261.15 KOO22674.1 - 0.5 9.4 14.6 0.31 10.0 8.4 1.7 1 1 1 2 2 2 0 Tropomyosin UAA PF08449.6 KOO22675.1 - 7.9e-69 231.8 11.5 9.1e-69 231.6 8.0 1.0 1 0 0 1 1 1 1 UAA transporter family DUF2619 PF10942.3 KOO22675.1 - 0.16 11.9 5.3 4.6 7.2 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2619) EF-hand_6 PF13405.1 KOO22676.1 - 6.7e-29 97.1 19.2 2.6e-06 26.8 0.4 5.5 6 0 0 6 6 6 5 EF-hand domain EF-hand_1 PF00036.27 KOO22676.1 - 1.5e-27 92.7 16.0 2.9e-06 26.1 0.1 5.3 5 0 0 5 5 5 5 EF hand EF-hand_7 PF13499.1 KOO22676.1 - 2.2e-25 88.5 9.0 2.3e-10 40.4 0.1 3.9 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.1 KOO22676.1 - 1.6e-21 75.6 3.1 6.8e-07 28.8 0.1 3.5 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO22676.1 - 2e-18 64.8 21.6 2.5e-05 23.4 0.2 5.3 5 0 0 5 5 5 5 EF hand EF-hand_10 PF14788.1 KOO22676.1 - 0.0035 16.9 5.0 19 4.9 0.0 4.6 5 0 0 5 5 5 0 EF hand SPARC_Ca_bdg PF10591.4 KOO22676.1 - 0.0084 16.1 2.7 4.7 7.2 0.7 3.4 2 2 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region DUF3597 PF12200.3 KOO22676.1 - 0.23 11.8 2.3 8.2 6.8 0.2 3.2 1 1 0 2 2 2 0 Domain of unknown function (DUF3597) DUF3847 PF12958.2 KOO22676.1 - 0.27 11.0 2.7 0.19 11.5 0.5 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3847) Toprim_2 PF13155.1 KOO22676.1 - 0.92 9.8 7.1 64 3.9 0.3 4.3 1 1 3 4 4 4 0 Toprim-like RbsD_FucU PF05025.8 KOO22677.1 - 2e-11 44.4 0.0 2.1e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 RbsD / FucU transport protein family Ycf1 PF05758.7 KOO22679.1 - 0.033 11.9 0.0 0.033 11.9 0.0 1.0 1 0 0 1 1 1 0 Ycf1 CTP_transf_2 PF01467.21 KOO22680.1 - 2.1e-14 53.8 0.0 3.7e-14 53.0 0.0 1.4 1 1 0 1 1 1 1 Cytidylyltransferase AIG2 PF06094.7 KOO22681.1 - 0.036 14.5 0.0 0.053 14.0 0.0 1.3 1 0 0 1 1 1 0 AIG2-like family Pkinase PF00069.20 KOO22683.1 - 4.2e-40 137.5 0.0 6.1e-40 137.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22683.1 - 2.7e-27 95.4 0.0 4.2e-27 94.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase ADH_zinc_N_2 PF13602.1 KOO22684.1 - 1.1e-12 49.0 0.0 2.2e-12 47.9 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 KOO22684.1 - 1.3e-12 47.3 0.0 2.4e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOO22684.1 - 0.00099 18.8 0.1 0.0023 17.6 0.0 1.7 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Methyltransf_16 PF10294.4 KOO22684.1 - 0.076 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase TIG PF01833.19 KOO22685.1 - 0.00028 20.8 0.0 1.9 8.5 0.0 3.0 3 0 0 3 3 3 2 IPT/TIG domain Sugar_tr PF00083.19 KOO22686.1 - 1.9e-82 277.2 20.2 2.3e-82 276.9 14.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOO22686.1 - 8.8e-16 57.5 60.8 9.8e-14 50.8 24.0 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_C1 PF00112.18 KOO22687.1 - 1.9e-35 122.7 7.7 2.8e-35 122.2 5.3 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.10 KOO22687.1 - 0.0048 15.4 0.1 0.0074 14.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase C1-like family ShK PF01549.19 KOO22688.1 - 4.2e-44 148.6 77.5 1.5e-08 34.8 4.7 6.1 6 0 0 6 6 6 6 ShK domain-like EF-hand_7 PF13499.1 KOO22689.1 - 2.9e-70 232.3 37.0 2.8e-10 40.1 0.4 11.4 8 3 1 10 10 10 8 EF-hand domain pair EF-hand_6 PF13405.1 KOO22689.1 - 3.6e-68 219.3 51.0 9e-05 22.0 0.1 19.5 20 0 0 20 20 20 15 EF-hand domain EF-hand_1 PF00036.27 KOO22689.1 - 4.3e-64 207.0 68.5 3.9e-05 22.6 0.0 19.2 19 0 0 19 19 19 15 EF hand EF-hand_8 PF13833.1 KOO22689.1 - 1.2e-35 120.8 55.2 1.4e-06 27.7 0.6 16.6 11 7 7 18 18 18 12 EF-hand domain pair EF-hand_5 PF13202.1 KOO22689.1 - 8.2e-34 113.4 66.5 0.0056 15.9 0.6 17.3 17 0 0 17 17 17 14 EF hand Abhydrolase_2 PF02230.11 KOO22689.1 - 8.6e-12 44.9 0.0 1.5e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 KOO22689.1 - 2.1e-08 34.0 0.0 6.3e-08 32.4 0.0 1.8 1 0 0 1 1 1 1 Alpha/beta hydrolase family EF-hand_10 PF14788.1 KOO22689.1 - 3.6e-06 26.5 10.8 6.2 6.5 0.0 10.0 11 1 0 11 11 11 1 EF hand Abhydrolase_6 PF12697.2 KOO22689.1 - 9.4e-05 22.3 0.5 0.47 10.2 0.2 2.7 1 1 1 2 2 2 2 Alpha/beta hydrolase family SPARC_Ca_bdg PF10591.4 KOO22689.1 - 0.00072 19.5 13.1 0.24 11.4 0.0 6.9 7 2 0 7 7 6 1 Secreted protein acidic and rich in cysteine Ca binding region LIP PF03583.9 KOO22689.1 - 0.0011 18.2 0.0 0.002 17.3 0.0 1.3 1 0 0 1 1 1 1 Secretory lipase Peptidase_S9 PF00326.16 KOO22689.1 - 0.0013 18.0 0.0 0.0058 15.8 0.0 2.0 2 0 0 2 2 2 1 Prolyl oligopeptidase family EF-hand_4 PF12763.2 KOO22689.1 - 0.021 14.5 13.6 3.2 7.5 0.0 7.0 6 2 0 6 6 6 0 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.8 KOO22689.1 - 0.09 12.3 0.3 38 3.7 0.0 4.6 7 0 0 7 7 7 0 Caleosin related protein EF-hand_7 PF13499.1 KOO22691.1 - 2.3e-22 78.9 15.6 1e-05 25.5 1.2 7.2 5 2 3 8 8 8 7 EF-hand domain pair EF-hand_1 PF00036.27 KOO22691.1 - 6.8e-22 75.0 15.2 0.0018 17.4 0.0 8.4 8 0 0 8 8 8 6 EF hand EF-hand_6 PF13405.1 KOO22691.1 - 2.2e-20 70.6 17.9 0.0062 16.3 0.0 8.2 8 0 0 8 8 8 6 EF-hand domain EF-hand_8 PF13833.1 KOO22691.1 - 1.9e-13 49.8 15.2 0.0051 16.3 0.1 7.0 6 1 1 7 7 7 5 EF-hand domain pair EF-hand_5 PF13202.1 KOO22691.1 - 2.4e-10 39.2 13.6 0.23 10.8 0.1 7.2 7 0 0 7 7 7 5 EF hand EF-hand_10 PF14788.1 KOO22691.1 - 0.0024 17.5 0.5 6.2 6.5 0.0 4.6 5 1 1 6 6 6 2 EF hand Metallophos PF00149.23 KOO22692.1 - 0.00038 19.9 0.0 0.00074 18.9 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Lumazine_bd_2 PF12893.2 KOO22693.1 - 1.1e-28 100.0 0.0 1.5e-15 57.7 0.0 2.5 2 1 0 2 2 2 2 Putative lumazine-binding DUF4440 PF14534.1 KOO22693.1 - 0.004 17.3 0.0 0.11 12.6 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4440) SnoaL_4 PF13577.1 KOO22693.1 - 0.01 15.7 0.0 0.25 11.2 0.0 2.2 2 0 0 2 2 2 0 SnoaL-like domain Pkinase PF00069.20 KOO22694.1 - 7.6e-19 67.8 0.0 1.7e-11 43.7 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22694.1 - 1.2e-08 34.3 0.2 2.2e-08 33.5 0.2 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase CS PF04969.11 KOO22694.1 - 0.00092 19.7 0.0 0.0021 18.5 0.0 1.7 1 0 0 1 1 1 1 CS domain Trypan_PARP PF05887.6 KOO22694.1 - 0.007 16.1 19.0 0.007 16.1 13.2 4.3 4 0 0 4 4 4 2 Procyclic acidic repetitive protein (PARP) SPOC PF07744.8 KOO22694.1 - 0.12 12.8 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 SPOC domain Thioredoxin PF00085.15 KOO22695.1 - 0.01 15.4 0.0 0.021 14.4 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_8 PF13905.1 KOO22695.1 - 0.16 12.0 0.0 0.28 11.3 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like GPS PF01825.16 KOO22698.1 - 6.6e-10 38.9 4.5 1.3e-09 37.9 3.1 1.4 1 0 0 1 1 1 1 Latrophilin/CL-1-like GPS domain zf-C3HC4_3 PF13920.1 KOO22699.1 - 8.6e-07 28.5 11.6 8.6e-07 28.5 8.0 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO22699.1 - 9.1e-07 28.6 14.7 9.1e-07 28.6 10.2 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 KOO22699.1 - 0.00013 21.9 14.7 0.00013 21.9 10.2 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO22699.1 - 0.00014 21.4 12.1 0.00014 21.4 8.4 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.20 KOO22699.1 - 0.00019 20.9 11.8 0.00019 20.9 8.2 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 KOO22699.1 - 0.00064 19.3 9.2 0.0013 18.3 6.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger PA PF02225.17 KOO22699.1 - 0.022 14.4 0.5 0.053 13.2 0.3 1.6 1 0 0 1 1 1 0 PA domain DUF1192 PF06698.6 KOO22699.1 - 0.024 14.4 2.3 0.054 13.3 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) DUF837 PF05769.6 KOO22699.1 - 0.16 11.5 0.1 0.24 10.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF837) zf-C3HC4_4 PF15227.1 KOO22699.1 - 4.8 7.1 17.5 9 6.2 10.2 2.4 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING THUMP PF02926.12 KOO22701.1 - 1.9e-10 40.7 0.0 2.6e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 THUMP domain DUF2378 PF09536.5 KOO22701.1 - 0.033 13.6 0.1 0.064 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2378) Chloroa_b-bind PF00504.16 KOO22702.1 - 5.4e-09 36.4 0.4 9.6e-09 35.6 0.2 1.4 1 1 0 1 1 1 1 Chlorophyll A-B binding protein EF-hand_7 PF13499.1 KOO22703.1 - 5.2e-16 58.5 6.8 2.6e-07 30.6 0.0 3.8 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO22703.1 - 1.7e-14 51.9 2.6 0.00011 21.2 0.5 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 KOO22703.1 - 2.1e-14 52.0 1.5 0.0026 17.5 0.2 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.1 KOO22703.1 - 1.6e-10 39.8 1.5 0.00093 18.4 0.3 3.4 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO22703.1 - 5.8e-08 32.2 3.8 0.0019 17.7 0.1 4.2 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.2 KOO22703.1 - 3.9e-06 26.5 0.1 0.0012 18.5 0.0 2.6 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO22703.1 - 0.0025 17.7 0.0 0.12 12.2 0.0 2.7 2 2 0 2 2 2 1 EF-hand domain Hypoth_Ymh PF09509.5 KOO22703.1 - 0.059 13.0 1.8 3.3 7.3 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (Hypoth_ymh) Pkinase PF00069.20 KOO22704.1 - 4.7e-58 196.3 0.0 5.8e-58 196.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22704.1 - 5.6e-30 104.2 0.0 6.6e-30 104.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO22704.1 - 4.6e-08 33.0 0.0 0.0018 18.0 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO22704.1 - 5e-07 28.9 0.0 1.8e-06 27.1 0.0 1.8 2 0 0 2 2 2 1 Kinase-like YrbL-PhoP_reg PF10707.4 KOO22704.1 - 0.015 14.6 0.0 0.028 13.7 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Kdo PF06293.9 KOO22704.1 - 0.085 11.9 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Aminotran_3 PF00202.16 KOO22705.1 - 2.5e-32 112.0 0.0 3.6e-32 111.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.16 KOO22705.1 - 0.053 12.6 0.0 0.18 10.9 0.0 1.8 1 1 0 1 1 1 0 Beta-eliminating lyase Aminotran_1_2 PF00155.16 KOO22705.1 - 0.054 12.4 0.1 0.13 11.1 0.0 1.6 2 0 0 2 2 2 0 Aminotransferase class I and II ketoacyl-synt PF00109.21 KOO22706.1 - 2.6e-09 36.9 0.3 5.3e-09 35.9 0.1 1.5 1 1 1 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Pkinase PF00069.20 KOO22707.1 - 5.4e-17 61.8 0.0 1.1e-16 60.7 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 KOO22707.1 - 0.00045 20.0 0.0 0.0027 17.4 0.0 2.2 3 1 1 4 4 4 1 Phosphotransferase enzyme family Kdo PF06293.9 KOO22707.1 - 0.00067 18.7 0.0 0.0011 18.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.12 KOO22707.1 - 0.024 13.7 0.0 0.069 12.2 0.0 1.7 1 1 0 1 1 1 0 Protein tyrosine kinase PaO PF08417.7 KOO22708.1 - 3.3e-18 65.3 0.0 1.1e-17 63.6 0.0 1.9 2 0 0 2 2 2 1 Pheophorbide a oxygenase Rieske PF00355.21 KOO22708.1 - 6.5e-18 64.1 0.0 1.2e-17 63.2 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain FA_desaturase PF00487.19 KOO22710.1 - 6.1e-13 48.8 1.7 8e-13 48.4 1.2 1.1 1 0 0 1 1 1 1 Fatty acid desaturase ShK PF01549.19 KOO22711.1 - 3.8e-36 123.1 60.8 6.1e-11 42.4 4.6 5.1 5 0 0 5 5 5 5 ShK domain-like NYD-SP28_assoc PF14775.1 KOO22712.1 - 9e-13 47.7 0.1 9e-13 47.7 0.1 2.9 4 0 0 4 4 4 1 Sperm tail C-terminal domain NYD-SP28 PF14772.1 KOO22712.1 - 2.7e-09 37.0 16.8 2.7e-09 37.0 11.7 4.7 2 2 2 4 4 4 1 Sperm tail Pox_LP_H2 PF03356.10 KOO22712.1 - 1.2 8.7 4.7 0.51 10.0 0.4 2.3 2 0 0 2 2 2 0 Viral late protein H2 LMBR1 PF04791.11 KOO22712.1 - 7.9 4.9 10.6 0.16 10.5 1.1 2.1 1 1 0 2 2 2 0 LMBR1-like membrane protein Choline_transpo PF04515.7 KOO22713.1 - 5.5e-55 186.4 11.9 5.5e-55 186.4 8.2 2.1 2 1 0 2 2 2 1 Plasma-membrane choline transporter DUF3413 PF11893.3 KOO22713.1 - 3.8 6.3 10.9 1.3 7.7 5.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3413) tRNA-synt_1c PF00749.16 KOO22715.1 - 1.3e-98 329.5 0.0 1.7e-98 329.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 KOO22715.1 - 5.9e-57 192.1 0.0 1e-56 191.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain CLASP_N PF12348.3 KOO22717.1 - 4.3e-19 68.7 0.4 5.6e-19 68.4 0.3 1.1 1 0 0 1 1 1 1 CLASP N terminal HEAT_2 PF13646.1 KOO22717.1 - 0.00087 19.5 1.4 0.00087 19.5 1.0 3.3 1 1 2 3 3 3 2 HEAT repeats Apolipoprotein PF01442.13 KOO22717.1 - 0.045 13.2 2.1 0.079 12.4 0.6 1.9 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain HEAT PF02985.17 KOO22717.1 - 0.19 11.9 0.2 0.19 11.9 0.2 4.9 5 2 1 6 6 6 0 HEAT repeat WD40 PF00400.27 KOO22718.1 - 7.5e-22 76.3 2.5 2.9e-08 33.2 0.7 5.7 6 0 0 6 6 6 3 WD domain, G-beta repeat Lipase_3 PF01764.20 KOO22720.1 - 4.4e-25 87.9 0.0 6.2e-25 87.4 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.2 KOO22720.1 - 0.0061 16.4 0.2 0.0071 16.2 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO22720.1 - 0.19 11.4 1.6 0.26 11.0 1.1 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family Defensin_2 PF01097.13 KOO22720.1 - 2.2 8.0 10.1 0.56 9.9 4.1 2.1 2 0 0 2 2 2 0 Arthropod defensin FdhE PF04216.7 KOO22721.1 - 0.021 14.5 1.6 0.03 14.0 1.1 1.3 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation TrkA_N PF02254.13 KOO22721.1 - 0.081 12.9 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain EF-hand_7 PF13499.1 KOO22722.1 - 1.2e-08 35.0 0.0 0.00043 20.3 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO22722.1 - 6.7e-08 31.2 2.8 0.0016 17.5 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO22722.1 - 4.1e-07 29.3 0.1 0.014 15.2 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO22722.1 - 2.7e-06 26.4 5.0 0.0023 17.1 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO22722.1 - 0.00086 18.8 1.7 0.83 9.3 0.2 2.3 2 0 0 2 2 2 2 EF-hand domain pair PCIF1_WW PF12237.3 KOO22723.1 - 9.1e-50 168.3 0.0 1.3e-49 167.8 0.0 1.2 1 0 0 1 1 1 1 Phosphorylated CTD interacting factor 1 WW domain Dam PF05869.6 KOO22723.1 - 0.11 11.8 0.0 0.25 10.7 0.0 1.5 1 0 0 1 1 1 0 DNA N-6-adenine-methyltransferase (Dam) Pkinase PF00069.20 KOO22724.1 - 1e-30 106.7 0.0 1.3e-30 106.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22724.1 - 3.1e-14 52.6 0.0 3.8e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO22724.1 - 0.0038 16.2 0.0 0.0052 15.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like EF-hand_1 PF00036.27 KOO22725.1 - 0.016 14.4 0.2 0.2 11.0 0.0 2.4 2 0 0 2 2 2 0 EF hand TPR_11 PF13414.1 KOO22726.1 - 3.4e-12 45.8 6.9 5.5e-07 29.1 1.7 2.5 1 1 1 2 2 2 2 TPR repeat TPR_9 PF13371.1 KOO22726.1 - 6.5e-12 45.1 4.4 3.4e-05 23.5 0.2 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO22726.1 - 1.2e-06 27.8 6.2 0.0014 18.1 0.1 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO22726.1 - 2.6e-05 23.7 15.5 0.0033 17.2 0.1 3.9 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO22726.1 - 3.7e-05 24.2 11.9 0.00027 21.5 1.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO22726.1 - 0.00024 20.9 1.4 0.00062 19.6 1.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO22726.1 - 0.00095 18.9 0.0 1.4 8.8 0.0 2.6 2 1 0 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.1 KOO22726.1 - 0.0034 17.4 2.2 3.6 8.0 0.2 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO22726.1 - 0.12 12.2 1.1 6.9 6.7 0.0 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat BTAD PF03704.12 KOO22726.1 - 0.14 12.4 4.5 2.5 8.4 0.1 2.8 3 0 0 3 3 3 0 Bacterial transcriptional activator domain ENOD40 PF08247.6 KOO22726.1 - 0.15 11.8 1.0 0.3 10.9 0.7 1.5 1 0 0 1 1 1 0 ENOD40 protein TPR_14 PF13428.1 KOO22726.1 - 2 9.2 10.6 2.8 8.8 0.0 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat CBFB_NFYA PF02045.10 KOO22727.1 - 1.2e-14 54.5 5.8 2.1e-14 53.8 4.0 1.4 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B ATG16 PF08614.6 KOO22728.1 - 0.084 12.6 48.8 1.3 8.8 1.0 5.2 2 1 3 5 5 5 0 Autophagy protein 16 (ATG16) DUF4201 PF13870.1 KOO22728.1 - 1.1 8.6 22.6 0.4 10.1 2.3 4.8 3 1 2 5 5 5 0 Domain of unknown function (DUF4201) Nsp1_C PF05064.8 KOO22728.1 - 1.4 8.5 19.2 0.77 9.4 1.5 4.7 3 2 2 5 5 5 0 Nsp1-like C-terminal region PLDc_2 PF13091.1 KOO22730.1 - 2.9e-13 49.6 0.0 2.2e-06 27.4 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.17 KOO22730.1 - 0.045 13.5 0.7 0.7 9.7 0.0 2.5 2 0 0 2 2 2 0 Phospholipase D Active site motif AA_permease_2 PF13520.1 KOO22731.1 - 1.7e-36 125.7 19.9 1.7e-36 125.7 13.8 2.2 3 0 0 3 3 3 1 Amino acid permease MFS_1 PF07690.11 KOO22731.1 - 2.2e-20 72.6 47.8 1e-19 70.4 15.5 4.5 2 2 1 3 3 3 2 Major Facilitator Superfamily AA_permease PF00324.16 KOO22731.1 - 9.1e-20 70.4 18.5 9.1e-20 70.4 12.8 2.8 3 0 0 3 3 3 2 Amino acid permease EcKinase PF02958.15 KOO22732.1 - 2.7e-12 46.4 0.0 4.9e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 Ecdysteroid kinase APH PF01636.18 KOO22732.1 - 1.2e-08 35.0 0.1 1.8e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.6 KOO22732.1 - 0.00014 20.6 0.0 0.00018 20.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) 2OG-FeII_Oxy_2 PF13532.1 KOO22733.1 - 1.3e-38 132.8 0.0 2.3e-38 132.0 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-C2HC5 PF06221.8 KOO22733.1 - 2e-15 56.2 6.8 3.8e-15 55.3 4.7 1.4 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type ASCH PF04266.9 KOO22733.1 - 3.3e-15 56.3 0.0 6.3e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 ASCH domain 2OG-FeII_Oxy_3 PF13640.1 KOO22733.1 - 0.098 13.1 0.0 0.26 11.8 0.0 1.7 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily tRNA-synt_2 PF00152.15 KOO22734.1 - 7.4e-77 258.3 0.0 1e-76 257.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 KOO22734.1 - 1.6e-06 27.8 0.0 2.7e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 KOO22734.1 - 0.00013 21.2 0.1 0.056 12.6 0.0 2.5 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) tRNA_anti_2 PF13742.1 KOO22734.1 - 0.012 15.4 0.0 0.027 14.3 0.0 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain NARP1 PF12569.3 KOO22734.1 - 0.13 10.9 0.8 0.19 10.4 0.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF3987 PF13148.1 KOO22734.1 - 2.3 6.7 5.6 3.5 6.0 3.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) HMG_box PF00505.14 KOO22735.1 - 2.7e-15 56.3 0.1 2.7e-15 56.3 0.1 2.4 2 1 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO22735.1 - 2.2e-11 43.9 0.4 2.2e-11 43.9 0.2 2.2 2 1 1 3 3 3 1 HMG-box domain CAF-1_p150 PF11600.3 KOO22735.1 - 0.5 9.7 35.4 0.12 11.7 0.3 3.1 3 0 0 3 3 3 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal TMPIT PF07851.8 KOO22735.1 - 2.6 7.0 3.9 3.8 6.5 2.7 1.2 1 0 0 1 1 1 0 TMPIT-like protein LRR_4 PF12799.2 KOO22736.1 - 2.4e-09 36.5 1.0 1.6e-05 24.3 0.0 2.8 1 1 3 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO22736.1 - 5e-09 35.7 3.0 8.5e-09 35.0 0.6 2.5 2 0 0 2 2 2 1 Leucine rich repeat LRR_9 PF14580.1 KOO22736.1 - 5.9e-05 22.6 0.1 0.00013 21.5 0.0 1.6 1 0 0 1 1 1 1 Leucine-rich repeat LRR_1 PF00560.28 KOO22736.1 - 0.002 17.8 1.0 3.6 7.9 0.0 3.9 3 0 0 3 3 3 1 Leucine Rich Repeat IQ PF00612.22 KOO22736.1 - 0.012 15.2 27.3 0.016 14.7 0.1 5.8 6 0 0 6 6 6 0 IQ calmodulin-binding motif LRR_7 PF13504.1 KOO22736.1 - 0.014 15.4 5.3 0.29 11.4 0.0 3.9 4 0 0 4 4 4 0 Leucine rich repeat LRR_6 PF13516.1 KOO22736.1 - 0.51 10.5 2.2 9.9 6.5 0.0 3.1 3 0 0 3 3 3 0 Leucine Rich repeat Glyco_hydro_43 PF04616.9 KOO22737.1 - 8.4e-07 28.3 0.0 1.3e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Bromodomain PF00439.20 KOO22738.1 - 1e-40 137.5 0.0 1e-19 70.2 0.0 2.4 2 0 0 2 2 2 2 Bromodomain YscJ_FliF PF01514.12 KOO22738.1 - 0.055 12.6 0.1 0.085 12.0 0.0 1.2 1 0 0 1 1 1 0 Secretory protein of YscJ/FliF family tRNA_synt_1c_R2 PF04557.10 KOO22739.1 - 9.4 7.0 6.9 4.2 8.1 0.2 2.8 1 1 1 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 PCRF PF03462.13 KOO22740.1 - 0.00087 18.9 0.0 0.0019 17.8 0.0 1.6 1 0 0 1 1 1 1 PCRF domain IATP PF04568.7 KOO22740.1 - 0.06 13.3 0.8 0.11 12.5 0.6 1.4 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP Exo_endo_phos PF03372.18 KOO22741.1 - 2.8e-10 40.5 1.1 5.4e-10 39.6 0.8 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 KOO22741.1 - 0.036 13.6 0.0 0.063 12.8 0.0 1.4 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase tRNA-synt_1 PF00133.17 KOO22742.1 - 4.8e-187 622.6 0.0 2.2e-186 620.4 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 KOO22742.1 - 1.1e-38 132.3 0.1 2.1e-38 131.4 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 KOO22742.1 - 7.9e-16 57.6 0.1 1.8e-06 26.9 0.1 4.6 3 2 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.1 KOO22742.1 - 5.9e-10 38.7 0.0 1.1e-05 24.8 0.0 2.4 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.4 KOO22742.1 - 1.1e-08 35.0 0.9 2.3e-08 34.0 0.1 2.0 2 0 0 2 2 2 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1e PF01406.14 KOO22742.1 - 0.00049 19.3 0.0 0.38 9.8 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1c PF00749.16 KOO22742.1 - 0.038 12.6 0.1 0.091 11.4 0.1 1.6 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain DUF4124 PF13511.1 KOO22742.1 - 0.06 13.4 0.0 0.19 11.8 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4124) Pribosyltran PF00156.22 KOO22743.1 - 6.2e-18 64.7 0.0 1.2e-17 63.8 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Ham1p_like PF01725.11 KOO22743.1 - 0.1 11.9 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Ham1 family Trypsin_2 PF13365.1 KOO22744.1 - 8.8e-17 61.1 0.2 1.7e-16 60.2 0.1 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.21 KOO22744.1 - 4.7e-13 49.2 0.0 7.5e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 Trypsin Peptidase_S46 PF10459.4 KOO22744.1 - 0.0018 16.7 0.5 0.0071 14.8 0.3 1.7 2 0 0 2 2 2 1 Peptidase S46 Peptidase_S7 PF00949.16 KOO22744.1 - 0.073 12.4 0.4 0.14 11.6 0.3 1.4 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease CBS PF00571.23 KOO22745.1 - 1.7e-25 88.4 0.6 1.4e-12 47.1 0.1 2.7 2 0 0 2 2 2 2 CBS domain DHH PF01368.15 KOO22745.1 - 3.1e-11 43.1 0.0 7.2e-11 41.9 0.0 1.6 1 1 0 1 1 1 1 DHH family Lactonase PF10282.4 KOO22745.1 - 0.0089 15.1 0.0 0.013 14.5 0.0 1.2 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller EF-hand_7 PF13499.1 KOO22747.1 - 2.5e-29 101.1 15.2 1.6e-10 40.9 0.0 3.6 1 1 3 4 4 4 4 EF-hand domain pair Thioredoxin PF00085.15 KOO22747.1 - 1.2e-26 92.4 0.2 2.1e-26 91.6 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin EF-hand_5 PF13202.1 KOO22747.1 - 1.3e-25 87.4 16.7 2.5e-07 29.7 0.5 4.9 5 0 0 5 5 5 4 EF hand EF-hand_1 PF00036.27 KOO22747.1 - 3.9e-24 82.0 11.1 2.1e-05 23.4 0.2 5.3 5 1 0 5 5 5 4 EF hand EF-hand_6 PF13405.1 KOO22747.1 - 8.2e-24 81.3 8.5 5.9e-06 25.7 0.3 5.3 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.1 KOO22747.1 - 5.2e-18 64.4 6.4 0.0022 17.5 0.0 4.5 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO22747.1 - 3.9e-06 26.8 0.1 0.014 15.4 0.0 3.0 2 1 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region Thioredoxin_2 PF13098.1 KOO22747.1 - 5.1e-05 23.4 0.2 0.00043 20.4 0.1 2.5 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 KOO22747.1 - 6.3e-05 23.0 0.0 0.00012 22.0 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_7 PF13899.1 KOO22747.1 - 0.0014 18.5 0.1 0.0037 17.2 0.1 1.7 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.1 KOO22747.1 - 0.028 13.9 0.0 0.044 13.3 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin Glutaredoxin PF00462.19 KOO22747.1 - 0.052 13.5 0.1 4.8 7.2 0.0 3.2 3 0 0 3 3 3 0 Glutaredoxin AhpC-TSA PF00578.16 KOO22747.1 - 0.1 12.2 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 AhpC/TSA family Pentapeptide_4 PF13599.1 KOO22748.1 - 6.4e-15 54.7 0.0 0.1 12.3 0.0 6.5 5 1 1 6 6 6 3 Pentapeptide repeats (9 copies) EF-hand_1 PF00036.27 KOO22748.1 - 1.7e-09 36.2 1.1 0.00092 18.3 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO22748.1 - 4.1e-09 36.4 0.3 3.5e-08 33.4 0.2 2.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO22748.1 - 3.5e-06 26.4 0.2 0.017 14.9 0.1 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.1 KOO22748.1 - 8e-06 24.9 0.6 0.2 11.0 0.3 3.0 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO22748.1 - 0.00055 19.5 2.5 0.079 12.5 0.1 3.5 2 1 1 3 3 3 2 EF-hand domain pair SinI PF08671.5 KOO22748.1 - 0.0013 18.0 0.0 0.0062 15.9 0.0 2.2 1 0 0 1 1 1 1 Anti-repressor SinI MerR-DNA-bind PF09278.6 KOO22748.1 - 0.005 17.2 5.1 38 4.7 0.2 5.4 5 0 0 5 5 5 0 MerR, DNA binding SH3_3 PF08239.6 KOO22748.1 - 0.024 14.8 0.0 0.066 13.4 0.0 1.8 1 0 0 1 1 1 0 Bacterial SH3 domain MerR_1 PF13411.1 KOO22748.1 - 0.42 10.4 5.5 25 4.7 0.0 6.0 7 0 0 7 7 7 0 MerR HTH family regulatory protein EF-hand_6 PF13405.1 KOO22749.1 - 3.5e-20 70.0 2.2 1.8e-05 24.2 0.1 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.27 KOO22749.1 - 1.9e-17 61.1 5.1 6e-06 25.1 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO22749.1 - 4.2e-14 52.4 8.1 1.7e-06 28.0 0.3 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO22749.1 - 6.5e-11 41.0 7.7 1.9e-05 23.8 0.3 4.7 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO22749.1 - 6e-08 32.1 8.8 0.14 11.7 0.1 5.0 4 1 0 4 4 4 3 EF-hand domain pair Transcrip_act PF04949.8 KOO22749.1 - 0.0068 16.0 1.3 0.0068 16.0 0.9 2.6 3 0 0 3 3 3 1 Transcriptional activator Med9 PF07544.8 KOO22749.1 - 0.084 12.6 2.0 0.2 11.4 0.3 2.5 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Syntaxin-6_N PF09177.6 KOO22749.1 - 0.24 11.8 4.7 3.6 8.0 0.2 3.1 3 0 0 3 3 3 0 Syntaxin 6, N-terminal SPARC_Ca_bdg PF10591.4 KOO22749.1 - 0.58 10.2 3.3 4 7.4 0.7 2.9 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region DUF4618 PF15397.1 KOO22749.1 - 0.76 9.0 5.8 0.35 10.1 0.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4618) TPR_MLP1_2 PF07926.7 KOO22749.1 - 7.9 6.2 8.1 4.6 6.9 0.7 3.2 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein Pyridoxal_deC PF00282.14 KOO22750.1 - 5.7e-18 64.4 0.0 8.6e-18 63.9 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.14 KOO22750.1 - 1.4e-07 30.6 0.0 3.5e-07 29.3 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class-V Na_Ca_ex PF01699.19 KOO22751.1 - 4.1e-23 81.5 9.5 6.3e-23 80.9 6.6 1.3 1 0 0 1 1 1 1 Sodium/calcium exchanger protein EF-hand_7 PF13499.1 KOO22751.1 - 1.3e-13 50.8 0.4 5.3e-08 32.8 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO22751.1 - 5e-11 41.0 0.1 0.02 14.1 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 KOO22751.1 - 7.9e-10 37.7 0.4 0.048 13.5 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.1 KOO22751.1 - 6.4e-09 34.7 1.9 0.032 13.5 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 KOO22751.1 - 1.1e-05 24.9 1.5 0.041 13.4 0.4 2.9 2 1 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO22751.1 - 0.0083 16.1 0.0 0.37 10.8 0.0 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Cbl_N2 PF02761.9 KOO22751.1 - 0.14 12.2 0.0 0.35 10.9 0.0 1.7 2 0 0 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain MadL PF03817.8 KOO22751.1 - 2.3 8.0 9.1 0.11 12.3 1.3 2.3 2 1 1 3 3 3 0 Malonate transporter MadL subunit Na_Ca_ex PF01699.19 KOO22752.1 - 2.9e-20 72.2 12.6 4.5e-20 71.6 8.7 1.2 1 0 0 1 1 1 1 Sodium/calcium exchanger protein HEAT PF02985.17 KOO22753.1 - 2.3e-05 24.1 15.2 0.45 10.7 0.0 6.8 6 0 0 6 6 6 3 HEAT repeat Vac14_Fab1_bd PF12755.2 KOO22753.1 - 0.0062 16.8 0.0 0.92 9.9 0.0 2.9 2 1 0 2 2 2 1 Vacuolar 14 Fab1-binding region HECT PF00632.20 KOO22754.1 - 2.2e-08 33.6 0.0 3.3e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Kelch_3 PF13415.1 KOO22755.1 - 1.8e-20 72.4 13.1 1.8e-06 27.9 0.1 5.7 4 1 1 5 5 5 5 Galactose oxidase, central domain Kelch_4 PF13418.1 KOO22755.1 - 7.6e-19 67.2 7.3 7.5e-06 25.6 0.0 5.2 4 1 1 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO22755.1 - 5.9e-15 54.8 9.8 0.0005 19.9 0.0 5.0 4 1 1 5 5 5 4 Kelch motif CUB PF00431.15 KOO22755.1 - 9.3e-15 54.6 0.0 1.6e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 CUB domain Kelch_1 PF01344.20 KOO22755.1 - 1.2e-12 47.1 0.4 0.00022 20.7 0.0 5.0 5 0 0 5 5 5 4 Kelch motif Kelch_6 PF13964.1 KOO22755.1 - 4.3e-11 42.4 8.5 0.00036 20.5 0.0 5.4 4 1 2 6 6 6 3 Kelch motif Kelch_2 PF07646.10 KOO22755.1 - 8.1e-09 34.9 8.5 0.036 13.8 0.0 5.4 3 1 2 5 5 5 4 Kelch motif DPM3 PF08285.6 KOO22756.1 - 4.8e-19 67.9 0.0 5.5e-19 67.8 0.0 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) DUF3094 PF11293.3 KOO22757.1 - 0.27 10.7 1.8 4.2 6.9 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) LysE PF01810.13 KOO22757.1 - 2.1 7.5 7.3 0.12 11.5 1.3 1.7 2 0 0 2 2 2 0 LysE type translocator RRM_DME PF15628.1 KOO22758.1 - 6.8e-07 28.9 0.0 1.7e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 RRM in Demeter PHD PF00628.24 KOO22758.1 - 2.9e-05 23.6 10.9 2.9e-05 23.6 7.5 2.5 2 0 0 2 2 2 1 PHD-finger HMG_box PF00505.14 KOO22758.1 - 0.00059 20.0 0.0 0.0015 18.7 0.0 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box Acetyltransf_1 PF00583.19 KOO22758.1 - 0.0044 17.0 0.1 0.013 15.5 0.1 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family HMG_box_2 PF09011.5 KOO22758.1 - 0.024 14.9 0.0 0.057 13.7 0.0 1.6 1 0 0 1 1 1 0 HMG-box domain HhH-GPD PF00730.20 KOO22758.1 - 0.03 14.6 0.0 1.4 9.1 0.0 2.6 2 0 0 2 2 2 0 HhH-GPD superfamily base excision DNA repair protein FR47 PF08445.5 KOO22758.1 - 0.11 12.2 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Glyco_hydro_3 PF00933.16 KOO22760.1 - 3.3e-40 137.9 0.0 5.2e-40 137.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain WW PF00397.21 KOO22761.1 - 0.0039 17.0 0.3 0.011 15.5 0.2 1.8 1 0 0 1 1 1 1 WW domain UPF0180 PF03698.8 KOO22762.1 - 0.1 12.4 4.3 6.4 6.7 0.0 3.6 4 0 0 4 4 4 0 Uncharacterised protein family (UPF0180) AMP-binding PF00501.23 KOO22763.1 - 3e-87 292.7 0.1 3.6e-87 292.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 KOO22763.1 - 1.2e-19 70.9 0.5 3.6e-19 69.4 0.4 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Nitroreductase PF00881.19 KOO22765.1 - 5.6e-17 62.0 0.0 7.8e-17 61.5 0.0 1.2 1 0 0 1 1 1 1 Nitroreductase family EF-hand_7 PF13499.1 KOO22766.1 - 5e-15 55.3 3.7 1.1e-06 28.7 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO22766.1 - 2.6e-13 49.3 6.3 1.3e-10 40.7 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO22766.1 - 7.2e-12 44.1 2.9 0.00038 20.0 0.2 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.27 KOO22766.1 - 3.7e-10 38.3 11.2 0.005 16.0 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.1 KOO22766.1 - 0.02 14.2 3.3 1.7 8.1 0.0 4.0 4 0 0 4 4 4 0 EF hand DMAP1 PF05499.7 KOO22767.1 - 6.5e-06 25.8 0.9 1.6e-05 24.4 0.1 1.9 2 0 0 2 2 2 1 DNA methyltransferase 1-associated protein 1 (DMAP1) Myb_DNA-binding PF00249.26 KOO22767.1 - 0.00039 20.4 0.5 0.0021 18.0 0.0 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO22767.1 - 0.013 15.6 0.1 0.035 14.1 0.0 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain EF-hand_1 PF00036.27 KOO22769.1 - 1.5e-18 64.6 0.8 2.6e-06 26.3 0.1 4.0 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.1 KOO22769.1 - 2.5e-16 59.5 0.3 1.7e-10 40.8 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO22769.1 - 1.4e-13 50.1 7.7 5.4e-08 32.3 0.2 4.1 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO22769.1 - 1.1e-11 43.5 4.9 0.024 14.5 0.1 4.3 3 1 1 4 4 4 3 EF-hand domain EF-hand_5 PF13202.1 KOO22769.1 - 2e-10 39.5 3.8 0.0084 15.4 0.0 4.6 4 1 1 5 5 5 3 EF hand EF-hand_4 PF12763.2 KOO22769.1 - 0.0036 16.9 1.0 1.1 8.9 0.1 2.9 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO22769.1 - 0.024 14.5 0.0 3.3 7.6 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain Ribosomal_L7Ae PF01248.21 KOO22770.1 - 3.1e-27 93.9 1.3 3.9e-27 93.6 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family X8 PF07983.8 KOO22770.1 - 0.041 14.3 0.1 0.062 13.8 0.0 1.3 1 0 0 1 1 1 0 X8 domain DUF4527 PF15030.1 KOO22770.1 - 0.049 12.9 0.2 0.061 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4527) PFK PF00365.15 KOO22771.1 - 1.5e-33 115.9 2.2 2.3e-33 115.3 1.6 1.2 1 0 0 1 1 1 1 Phosphofructokinase DUF2475 PF10629.4 KOO22772.1 - 2.7e-12 46.7 9.5 0.024 14.8 0.1 4.5 4 0 0 4 4 4 4 Protein of unknown function (DUF2475) Pax2_C PF12403.3 KOO22772.1 - 0.00086 18.9 11.1 0.83 9.3 0.1 4.4 2 2 2 4 4 4 3 Paired-box protein 2 C terminal Helicase_C PF00271.26 KOO22775.1 - 1.5e-14 53.5 0.0 2.4e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Sulfotransfer_1 PF00685.22 KOO22776.1 - 0.26 10.5 0.0 0.47 9.6 0.0 1.3 1 0 0 1 1 1 0 Sulfotransferase domain Glyco_hydro_39 PF01229.12 KOO22776.1 - 0.35 9.1 0.1 0.75 8.1 0.1 1.5 1 0 0 1 1 1 0 Glycosyl hydrolases family 39 DUF3638 PF12340.3 KOO22777.1 - 2e-20 72.7 0.5 5.6e-15 54.9 0.2 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF3638) DUF3645 PF12359.3 KOO22777.1 - 9.4e-17 59.8 0.2 2.7e-16 58.3 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) EF-hand_7 PF13499.1 KOO22777.1 - 1e-06 28.7 0.0 0.002 18.2 0.0 3.5 3 0 0 3 3 3 1 EF-hand domain pair Alpha_adaptin_C PF02296.11 KOO22777.1 - 7.6e-05 22.6 0.0 0.00019 21.3 0.0 1.6 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain DUF946 PF06101.6 KOO22777.1 - 0.00017 19.7 0.0 0.00029 18.9 0.0 1.2 1 0 0 1 1 1 1 Plant protein of unknown function (DUF946) EF-hand_6 PF13405.1 KOO22777.1 - 0.00032 20.3 0.3 2.1 8.4 0.0 4.7 5 0 0 5 5 5 1 EF-hand domain EF-hand_1 PF00036.27 KOO22777.1 - 0.0062 15.7 0.1 4.1 6.9 0.0 4.2 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.1 KOO22777.1 - 0.0063 16.1 0.7 0.14 11.8 0.0 3.1 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO22777.1 - 0.059 12.7 1.6 15 5.1 0.0 3.4 3 0 0 3 3 3 0 EF hand RmuC PF02646.11 KOO22777.1 - 0.11 11.2 0.0 0.22 10.3 0.0 1.4 1 0 0 1 1 1 0 RmuC family PurA PF04845.8 KOO22777.1 - 1.6 7.7 0.0 3.1 6.8 0.0 1.4 1 0 0 1 1 1 0 PurA ssDNA and RNA-binding protein 2-Hacid_dh_C PF02826.14 KOO22778.1 - 2.7e-52 176.4 0.1 4.1e-52 175.9 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 KOO22778.1 - 3.6e-24 84.7 0.2 5.2e-24 84.2 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 KOO22778.1 - 1.5e-06 28.1 0.2 4.1e-06 26.7 0.1 1.7 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.7 KOO22778.1 - 0.00044 19.6 0.0 0.0012 18.2 0.0 1.8 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_7 PF13241.1 KOO22778.1 - 0.0071 16.5 0.3 0.034 14.4 0.1 2.2 2 0 0 2 2 2 1 Putative NAD(P)-binding AlaDh_PNT_C PF01262.16 KOO22778.1 - 0.01 15.3 1.3 0.028 13.9 0.2 2.2 2 1 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain F420_oxidored PF03807.12 KOO22778.1 - 0.012 16.0 2.3 0.029 14.8 0.1 2.5 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.15 KOO22778.1 - 0.018 15.1 0.1 0.062 13.3 0.1 1.9 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.13 KOO22778.1 - 0.053 13.1 1.2 0.21 11.2 0.0 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.22 KOO22778.1 - 0.13 12.6 1.7 0.56 10.6 1.2 2.2 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase CH PF00307.26 KOO22779.1 - 9e-10 38.5 0.0 1.6e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CDC24 PF06395.6 KOO22779.1 - 0.004 17.1 0.0 0.0071 16.3 0.0 1.3 1 0 0 1 1 1 1 CDC24 Calponin Aa_trans PF01490.13 KOO22781.1 - 2.6e-62 210.6 21.7 3.1e-62 210.3 15.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 KOO22781.1 - 1.7e-09 36.9 16.9 2.1e-07 30.1 8.4 2.2 2 0 0 2 2 2 2 Tryptophan/tyrosine permease family DUF3733 PF12534.3 KOO22781.1 - 0.049 12.9 0.2 0.92 8.8 0.0 2.5 2 0 0 2 2 2 0 Leucine-rich repeat containing protein 8 SnoaL_2 PF12680.2 KOO22782.1 - 0.063 13.6 0.0 0.2 12.1 0.0 1.9 1 0 0 1 1 1 0 SnoaL-like domain AAA_13 PF13166.1 KOO22782.1 - 2.4 6.4 17.8 0.41 9.0 7.5 2.2 1 1 1 2 2 2 0 AAA domain DUF342 PF03961.8 KOO22782.1 - 4.1 5.7 17.7 0.66 8.3 4.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF342) Lumazine_bd PF12870.2 KOO22782.1 - 6.1 6.9 7.3 1.5 8.8 0.3 2.6 2 0 0 2 2 2 0 Lumazine-binding domain Sec8_exocyst PF04048.9 KOO22782.1 - 8.7 5.9 16.3 11 5.6 0.3 4.3 3 1 1 4 4 4 0 Sec8 exocyst complex component specific domain DUF4231 PF14015.1 KOO22784.1 - 0.014 15.3 2.5 0.3 11.1 0.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) DUF3040 PF11239.3 KOO22784.1 - 2.6 8.1 8.9 0.48 10.4 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) Cupin_4 PF08007.7 KOO22785.1 - 5.4e-33 114.5 0.0 8.7e-33 113.9 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.1 KOO22785.1 - 0.15 11.5 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Cupin-like domain HpaP PF09483.5 KOO22785.1 - 1.6 8.6 9.2 2.8 7.8 6.4 1.4 1 0 0 1 1 1 0 Type III secretion protein (HpaP) DEAD PF00270.24 KOO22787.1 - 1.5e-31 109.1 0.0 1.9e-31 108.8 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase CMS1 PF14617.1 KOO22787.1 - 0.00013 21.1 0.1 0.0015 17.6 0.0 2.1 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.1 KOO22787.1 - 0.00068 19.7 0.4 0.019 15.1 0.3 2.3 1 1 0 1 1 1 1 AAA domain ResIII PF04851.10 KOO22787.1 - 0.026 14.3 0.0 0.038 13.8 0.0 1.4 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit cNMP_binding PF00027.24 KOO22789.1 - 3.1e-06 26.9 0.3 0.00022 20.9 0.1 2.7 2 1 1 3 3 3 1 Cyclic nucleotide-binding domain DUF365 PF04033.7 KOO22789.1 - 0.036 14.0 0.3 0.087 12.8 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF365) DUF4609 PF15382.1 KOO22789.1 - 0.048 13.3 0.1 0.084 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4609) Peptidase_C69 PF03577.10 KOO22791.1 - 4.2e-51 174.0 0.0 6.4e-50 170.1 0.0 2.5 1 1 0 1 1 1 1 Peptidase family C69 BING4CT PF08149.6 KOO22791.1 - 1.7e-35 120.3 0.0 6.9e-34 115.2 0.0 2.4 2 0 0 2 2 2 1 BING4CT (NUC141) domain WD40 PF00400.27 KOO22791.1 - 1.1e-07 31.4 0.0 3.3e-06 26.7 0.0 3.3 3 0 0 3 3 3 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 KOO22791.1 - 0.097 11.4 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 Coatomer WD associated region Suppressor_APC PF11414.3 KOO22792.1 - 0.036 13.8 0.4 0.036 13.8 0.3 2.8 2 2 1 3 3 3 0 Adenomatous polyposis coli tumour suppressor protein PGC7_Stella PF15549.1 KOO22792.1 - 0.67 9.9 4.0 14 5.6 0.8 2.3 2 0 0 2 2 2 0 PGC7/Stella/Dppa3 domain Lge1 PF11488.3 KOO22792.1 - 1.1 9.4 9.5 0.18 12.0 2.2 2.7 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 AAA_23 PF13476.1 KOO22792.1 - 4.2 7.6 7.5 0.2 11.9 1.2 1.7 2 0 0 2 2 2 0 AAA domain Atg14 PF10186.4 KOO22792.1 - 4.3 6.1 8.1 1.5 7.6 2.1 2.0 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 HC2 PF07382.6 KOO22793.1 - 6.6 6.5 62.0 0.023 14.5 36.2 1.9 2 0 0 2 2 2 0 Histone H1-like nucleoprotein HC2 SHIPPO-rpt PF07004.7 KOO22795.1 - 6e-07 30.0 31.1 0.013 16.3 0.1 6.9 7 0 0 7 7 7 5 Sperm-tail PG-rich repeat DUF229 PF02995.12 KOO22796.1 - 4.8e-10 38.4 0.0 6.7e-10 37.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Pyr_redox_2 PF07992.9 KOO22798.1 - 1.2e-14 54.7 0.0 1.6e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOO22798.1 - 1e-10 41.8 0.0 3.3e-10 40.2 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase WD40 PF00400.27 KOO22799.1 - 6.6e-30 101.8 17.1 4.7e-09 35.7 0.0 9.2 9 0 0 9 9 9 6 WD domain, G-beta repeat Clathrin PF00637.15 KOO22799.1 - 0.00053 19.5 0.4 0.028 14.0 0.1 2.5 1 1 1 2 2 2 1 Region in Clathrin and VPS Coatomer_WDAD PF04053.9 KOO22799.1 - 0.002 16.9 0.5 2.8 6.6 0.0 4.3 5 0 0 5 5 5 1 Coatomer WD associated region zf-RING_2 PF13639.1 KOO22799.1 - 0.0022 17.7 4.9 0.0022 17.7 3.4 2.2 2 0 0 2 2 2 1 Ring finger domain Apc3 PF12895.2 KOO22799.1 - 0.036 14.2 7.7 4.5 7.4 0.1 4.0 4 1 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 KOO22799.1 - 0.052 13.8 5.5 0.13 12.5 0.1 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat PPR_2 PF13041.1 KOO22799.1 - 0.12 12.3 0.2 0.56 10.2 0.1 2.2 2 0 0 2 2 2 0 PPR repeat family Me-amine-dh_H PF06433.6 KOO22799.1 - 0.17 10.4 0.0 0.32 9.5 0.0 1.4 1 0 0 1 1 1 0 Methylamine dehydrogenase heavy chain (MADH) TPR_12 PF13424.1 KOO22799.1 - 0.48 10.3 5.5 5.5 6.9 0.1 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat Mito_carr PF00153.22 KOO22801.1 - 6.3e-42 141.2 3.8 1.1e-21 76.2 0.2 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein DUF1072 PF06380.6 KOO22801.1 - 2.8 7.6 5.5 0.5 10.0 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1072) PXPV PF12778.2 KOO22802.1 - 0.63 9.7 3.6 1.2 8.8 2.5 1.4 1 0 0 1 1 1 0 PXPV repeat (3 copies) LRR_8 PF13855.1 KOO22803.1 - 0.069 12.9 1.8 0.54 10.0 0.5 2.5 2 0 0 2 2 2 0 Leucine rich repeat F-box PF00646.28 KOO22803.1 - 0.1 12.3 0.2 0.3 10.7 0.2 1.9 1 0 0 1 1 1 0 F-box domain SNF2_N PF00176.18 KOO22805.1 - 3e-64 216.6 0.0 4.7e-64 216.0 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOO22805.1 - 4.6e-13 48.8 3.4 5.1e-13 48.6 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO22805.1 - 5e-05 23.2 0.0 0.00014 21.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 KOO22805.1 - 0.0022 17.5 0.0 0.0041 16.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SM_b PF10741.4 KOO22805.1 - 0.0036 16.8 0.1 0.024 14.2 0.1 2.2 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein M subtype b HDA2-3 PF11496.3 KOO22805.1 - 0.019 13.7 0.0 0.21 10.3 0.0 2.4 2 1 0 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 Pkinase PF00069.20 KOO22806.1 - 1.8e-25 89.5 0.0 3.7e-25 88.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22806.1 - 1.3e-24 86.7 0.0 2.4e-24 85.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4576 PF15144.1 KOO22808.1 - 1.5 8.4 3.9 2.7 7.7 2.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4576) Methyltransf_11 PF08241.7 KOO22809.1 - 1.7e-13 50.8 1.0 2.2e-13 50.4 0.1 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO22809.1 - 6.5e-12 45.7 0.8 2.2e-11 44.0 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO22809.1 - 7.7e-12 45.2 0.0 1.1e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO22809.1 - 1.9e-11 43.7 0.0 4e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO22809.1 - 1e-08 35.7 2.2 1.2e-08 35.4 0.2 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO22809.1 - 8.5e-06 26.0 0.4 2.2e-05 24.7 0.3 1.7 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.6 KOO22809.1 - 3.7e-05 23.1 0.0 8.5e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_26 PF13659.1 KOO22809.1 - 0.0011 18.9 0.9 0.0036 17.3 0.6 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO22809.1 - 0.0073 15.4 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Fmp27_WPPW PF10359.4 KOO22809.1 - 0.16 10.3 0.9 0.22 9.9 0.7 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain HMG_CoA_synt_N PF01154.12 KOO22813.1 - 6.8e-46 155.9 0.0 1.1e-45 155.3 0.0 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.5 KOO22813.1 - 1.1e-31 110.4 0.0 2.6e-29 102.6 0.0 2.3 1 1 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal WD40 PF00400.27 KOO22814.1 - 6.3e-20 70.2 5.5 4.5e-07 29.5 0.0 4.2 4 0 0 4 4 4 4 WD domain, G-beta repeat eIF2A PF08662.6 KOO22814.1 - 0.012 15.3 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A HEAT PF02985.17 KOO22815.1 - 1.8e-39 130.2 33.7 7.1e-05 22.5 0.1 13.1 13 0 0 13 13 13 8 HEAT repeat HEAT_2 PF13646.1 KOO22815.1 - 1.5e-26 92.5 16.9 0.00011 22.3 0.0 6.4 4 1 2 6 6 6 6 HEAT repeats TB2_DP1_HVA22 PF03134.14 KOO22815.1 - 5.4e-17 61.3 3.2 1.1e-16 60.3 2.2 1.5 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Vac14_Fab1_bd PF12755.2 KOO22815.1 - 2e-09 37.6 0.5 0.057 13.8 0.0 6.8 4 3 3 7 7 7 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.1 KOO22815.1 - 6.2e-05 23.3 30.9 1.6 9.2 0.3 9.2 6 3 4 10 10 10 4 HEAT-like repeat Arm PF00514.18 KOO22815.1 - 0.0006 19.5 1.8 1.1 9.2 0.0 4.8 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.15 KOO22815.1 - 0.0012 17.3 7.3 0.85 7.8 0.0 3.7 3 1 0 3 3 3 3 Adaptin N terminal region Proteasom_PSMB PF10508.4 KOO22815.1 - 0.021 13.1 2.6 0.31 9.2 0.1 2.9 3 0 0 3 3 3 0 Proteasome non-ATPase 26S subunit MMS19_N PF14500.1 KOO22815.1 - 0.044 13.0 0.2 42 3.2 0.0 4.1 5 0 0 5 5 5 0 Dos2-interacting transcription regulator of RNA-Pol-II Dus PF01207.12 KOO22816.1 - 3.8e-22 78.4 0.1 6.5e-22 77.7 0.1 1.4 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) DUF2967 PF11179.3 KOO22816.1 - 0.32 10.4 7.2 0.35 10.3 4.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2967) DUF1619 PF07773.6 KOO22817.1 - 1.4e-05 25.0 0.0 3.8e-05 23.6 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1619) SHIPPO-rpt PF07004.7 KOO22819.1 - 0.02 15.7 29.3 0.097 13.6 0.1 7.2 7 2 0 7 7 7 0 Sperm-tail PG-rich repeat Bestrophin PF01062.16 KOO22821.1 - 4.2e-19 68.5 1.4 6.6e-19 67.9 1.0 1.2 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Beta-lactamase PF00144.19 KOO22822.1 - 6.2e-14 51.7 0.2 6.6e-13 48.3 0.0 2.7 2 1 0 2 2 2 1 Beta-lactamase Peptidase_S11 PF00768.15 KOO22822.1 - 0.19 11.0 0.0 0.36 10.0 0.0 1.4 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase Helicase_C_2 PF13307.1 KOO22823.1 - 8.3e-51 172.2 0.0 1.3e-50 171.5 0.0 1.3 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.10 KOO22823.1 - 3.3e-31 108.0 0.2 4.9e-31 107.4 0.1 1.3 1 0 0 1 1 1 1 DEAD_2 tRNA_edit PF04073.10 KOO22824.1 - 0.072 12.9 0.9 94 2.8 0.0 5.1 5 2 2 7 7 7 0 Aminoacyl-tRNA editing domain FKBP_C PF00254.23 KOO22825.1 - 4.1e-27 94.0 0.0 2e-11 43.7 0.0 3.5 3 0 0 3 3 3 3 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_11 PF13414.1 KOO22825.1 - 2.1e-06 27.2 7.6 0.00096 18.7 3.0 3.0 2 1 1 3 3 3 3 TPR repeat TPR_2 PF07719.12 KOO22825.1 - 0.0026 17.5 6.0 0.21 11.6 0.5 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO22825.1 - 0.0066 16.0 6.9 1.7 8.3 0.3 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO22825.1 - 2.4 9.0 8.3 2.5 8.9 1.2 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat LRR_6 PF13516.1 KOO22826.1 - 5e-59 189.7 2.3 0.00098 18.9 0.0 12.4 12 0 0 12 12 12 12 Leucine Rich repeat LRR_1 PF00560.28 KOO22826.1 - 3e-06 26.4 0.0 44 4.6 0.0 8.2 10 1 0 10 10 10 0 Leucine Rich Repeat LRR_4 PF12799.2 KOO22826.1 - 4.6e-06 26.1 1.6 6.5 6.4 0.0 6.7 4 3 3 7 7 7 3 Leucine Rich repeats (2 copies) EIF_2_alpha PF07541.7 KOO22826.1 - 7.3e-05 22.4 8.3 0.79 9.4 0.1 5.4 1 1 2 6 6 6 3 Eukaryotic translation initiation factor 2 alpha subunit LRR_7 PF13504.1 KOO22826.1 - 0.00037 20.2 0.3 1.6e+02 3.2 0.0 6.6 7 0 0 7 7 7 0 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO22826.1 - 0.00046 20.3 7.5 2.2 8.5 0.1 5.5 3 2 3 6 6 6 2 RNA 2'-O ribose methyltransferase substrate binding CbiG_N PF11760.3 KOO22826.1 - 0.31 10.7 35.6 5.8 6.6 0.2 9.6 7 4 4 11 11 11 0 Cobalamin synthesis G N-terminal CCDC71L PF15374.1 KOO22826.1 - 3.8 6.7 4.6 36 3.5 0.0 3.9 4 2 1 6 6 6 0 Coiled-coil domain-containing protein 71L Peptidase_M16_C PF05193.16 KOO22827.1 - 2.9e-15 56.4 0.0 6.8e-08 32.4 0.0 3.6 2 1 1 3 3 3 3 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 KOO22827.1 - 1.1e-13 51.1 0.0 3.1e-13 49.7 0.0 1.8 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) AMP-binding PF00501.23 KOO22828.1 - 2.6e-45 154.5 0.2 6.7e-45 153.2 0.2 1.6 1 1 0 1 1 1 1 AMP-binding enzyme GH3 PF03321.8 KOO22828.1 - 0.018 13.6 0.0 0.92 7.9 0.0 2.1 2 0 0 2 2 2 0 GH3 auxin-responsive promoter Abhydrolase_5 PF12695.2 KOO22829.1 - 0.058 13.1 2.3 0.088 12.5 1.6 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family Ion_trans PF00520.26 KOO22830.1 - 3.7e-16 58.9 7.2 4.9e-16 58.5 5.0 1.2 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.24 KOO22830.1 - 1.2e-11 44.2 0.0 2.4e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.11 KOO22830.1 - 4.1e-07 29.6 2.9 4.1e-07 29.6 2.0 2.3 2 0 0 2 2 2 1 Ion channel FA_hydroxylase PF04116.8 KOO22831.1 - 4.5e-12 46.3 13.8 4.5e-12 46.3 9.6 1.6 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily UPF0154 PF03672.8 KOO22831.1 - 0.019 14.5 0.1 0.038 13.6 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) PNTB PF02233.11 KOO22831.1 - 0.048 12.4 1.3 0.059 12.1 0.9 1.1 1 0 0 1 1 1 0 NAD(P) transhydrogenase beta subunit ATPase_gene1 PF09527.5 KOO22831.1 - 0.06 13.1 0.8 0.21 11.4 0.6 1.9 1 0 0 1 1 1 0 Putative F0F1-ATPase subunit (ATPase_gene1) Esterase_phd PF10503.4 KOO22832.1 - 3.2e-10 39.6 0.6 5.1e-10 38.9 0.4 1.2 1 0 0 1 1 1 1 Esterase PHB depolymerase Abhydrolase_6 PF12697.2 KOO22832.1 - 7.5e-08 32.5 1.6 2.7e-07 30.6 1.1 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO22832.1 - 9.3e-08 31.9 0.1 1.6e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 KOO22832.1 - 1.8e-06 27.5 0.0 2.9e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Peptidase_S15 PF02129.13 KOO22832.1 - 1.4e-05 24.7 0.1 0.0019 17.6 0.1 2.2 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.16 KOO22832.1 - 0.00013 21.2 0.0 0.00027 20.2 0.0 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.11 KOO22832.1 - 0.00017 21.1 0.0 0.00035 20.0 0.0 1.4 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase DUF2048 PF09752.4 KOO22832.1 - 0.0028 16.5 0.1 0.0047 15.8 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2048) Lipase_3 PF01764.20 KOO22832.1 - 0.023 14.3 0.0 0.19 11.3 0.0 2.0 2 0 0 2 2 2 0 Lipase (class 3) AXE1 PF05448.7 KOO22832.1 - 0.06 11.8 0.0 0.1 11.0 0.0 1.4 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) DUF2974 PF11187.3 KOO22832.1 - 0.077 12.3 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) CBM_48 PF02922.13 KOO22832.1 - 0.084 12.9 0.1 1.4 9.0 0.0 2.3 2 0 0 2 2 2 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Abhydrolase_1 PF00561.15 KOO22832.1 - 0.09 12.3 1.6 0.15 11.6 0.7 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold 2OG-FeII_Oxy_3 PF13640.1 KOO22833.1 - 6.7e-07 29.7 0.0 9.2e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO22833.1 - 0.00083 18.9 0.0 0.0015 18.1 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Kinesin PF00225.18 KOO22834.1 - 1.2e-80 270.8 0.0 1.9e-80 270.0 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain IQ PF00612.22 KOO22834.1 - 0.00041 19.7 0.0 0.0014 18.0 0.0 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif TPR_MLP1_2 PF07926.7 KOO22834.1 - 0.04 13.6 16.5 0.092 12.4 11.4 1.6 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein LOH1CR12 PF10158.4 KOO22834.1 - 0.24 11.1 4.9 0.5 10.1 3.4 1.5 1 0 0 1 1 1 0 Tumour suppressor protein TSC22 PF01166.13 KOO22834.1 - 0.5 10.3 7.0 0.22 11.5 2.1 2.3 1 1 1 2 2 2 0 TSC-22/dip/bun family APG6 PF04111.7 KOO22834.1 - 3.1 6.7 14.2 4.9 6.0 9.8 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Lge1 PF11488.3 KOO22834.1 - 3.4 7.9 6.5 21 5.4 4.4 2.4 1 1 0 1 1 1 0 Transcriptional regulatory protein LGE1 DUF940 PF06082.6 KOO22835.1 - 1.2 7.6 5.0 2 6.8 3.5 1.5 1 0 0 1 1 1 0 Bacterial putative lipoprotein (DUF940) DAO PF01266.19 KOO22835.1 - 6.4 5.5 6.7 9.7 4.9 4.6 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase UbiA PF01040.13 KOO22836.1 - 1.4e-11 44.0 0.8 6.3e-08 32.1 0.1 2.3 1 1 1 2 2 2 2 UbiA prenyltransferase family Bac_rhodopsin PF01036.13 KOO22837.1 - 5.6e-26 91.2 8.5 7.3e-26 90.8 5.9 1.1 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein Vma12 PF11712.3 KOO22838.1 - 0.0011 18.7 0.0 0.0014 18.3 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase MFS_2 PF13347.1 KOO22838.1 - 0.0033 15.8 0.0 0.0038 15.7 0.0 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein Coiled PF05710.7 KOO22838.1 - 0.054 13.9 0.0 0.07 13.5 0.0 1.2 1 0 0 1 1 1 0 Coiled coil Cpn60_TCP1 PF00118.19 KOO22839.1 - 8.9e-145 483.0 1.0 1e-144 482.7 0.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DnaJ PF00226.26 KOO22840.1 - 3.9e-21 74.5 0.0 6.9e-21 73.7 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain Ank_2 PF12796.2 KOO22840.1 - 5.5e-21 74.7 9.0 1e-13 51.3 2.6 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO22840.1 - 6.2e-15 54.1 19.1 0.00033 20.3 0.3 5.9 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.1 KOO22840.1 - 1.5e-14 54.0 11.5 5.2e-08 33.1 0.3 4.4 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO22840.1 - 8.7e-14 51.2 14.0 8.6e-05 22.6 1.5 5.2 2 1 4 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO22840.1 - 8.6e-06 25.5 7.1 4 7.9 0.0 5.7 6 0 0 6 6 6 3 Ankyrin repeat Helicase_C PF00271.26 KOO22841.1 - 1.9e-11 43.6 0.0 3.6e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOO22841.1 - 2.1e-05 24.1 0.0 3.3e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase CKS PF01111.14 KOO22843.1 - 1.6e-38 130.3 0.1 1.9e-38 130.1 0.1 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit UPF0564 PF10595.4 KOO22844.1 - 1.6e-23 83.1 52.8 1.6e-23 83.1 36.6 2.0 2 0 0 2 2 2 1 Uncharacterised protein family UPF0564 TAF8_C PF10406.4 KOO22844.1 - 6.4 6.9 12.0 8.3 6.5 0.6 4.5 3 0 0 3 3 3 0 Transcription factor TFIID complex subunit 8 C-term HYLS1_C PF15311.1 KOO22845.1 - 1.3e-06 28.5 12.6 0.001 19.2 1.1 3.6 2 1 1 3 3 3 2 Hydrolethalus syndrome protein 1 C-terminus Abhydrolase_5 PF12695.2 KOO22846.1 - 3e-19 69.2 0.1 4e-19 68.8 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO22846.1 - 2.9e-08 33.8 2.1 1.5e-06 28.2 0.1 2.2 1 1 0 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO22846.1 - 4.8e-05 23.0 0.1 0.015 14.8 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold DUF818 PF05677.7 KOO22846.1 - 0.0069 15.1 0.0 0.0094 14.7 0.0 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Peptidase_S9 PF00326.16 KOO22846.1 - 0.018 14.2 0.1 0.23 10.6 0.1 2.1 1 1 0 1 1 1 0 Prolyl oligopeptidase family UPF0227 PF05728.7 KOO22846.1 - 0.037 13.7 0.0 2.7 7.6 0.0 2.2 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0227) DLH PF01738.13 KOO22846.1 - 0.048 12.9 0.0 0.073 12.3 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family Hydrolase_4 PF12146.3 KOO22846.1 - 0.086 12.7 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Putative lysophospholipase LIP PF03583.9 KOO22846.1 - 0.13 11.4 0.1 1.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Secretory lipase EF-hand_1 PF00036.27 KOO22847.1 - 1.1e-11 43.1 0.0 3.4e-06 25.9 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO22847.1 - 1.4e-09 37.0 0.0 5.6e-05 22.6 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO22847.1 - 5.7e-09 35.9 0.1 0.00027 21.0 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO22847.1 - 5.9e-09 34.8 0.0 5.4e-06 25.5 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO22847.1 - 3.1e-05 23.4 0.0 7.2e-05 22.3 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair Mod_r PF07200.8 KOO22847.1 - 0.0005 20.0 1.1 0.0011 18.9 0.8 1.5 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein Snapin_Pallidin PF14712.1 KOO22847.1 - 0.0019 18.4 0.3 0.0019 18.4 0.2 1.5 2 0 0 2 2 1 1 Snapin/Pallidin TMF_DNA_bd PF12329.3 KOO22847.1 - 0.0032 17.2 7.3 0.011 15.5 1.1 2.4 1 1 1 2 2 2 1 TATA element modulatory factor 1 DNA binding SlyX PF04102.7 KOO22847.1 - 0.0045 17.3 0.2 0.0094 16.2 0.1 1.5 1 0 0 1 1 1 1 SlyX TBPIP PF07106.8 KOO22847.1 - 0.0053 16.3 0.4 0.0083 15.6 0.3 1.3 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Matrilin_ccoil PF10393.4 KOO22847.1 - 0.0064 15.8 0.2 0.053 12.9 0.0 2.3 2 0 0 2 2 2 1 Trimeric coiled-coil oligomerisation domain of matrilin Tropomyosin_1 PF12718.2 KOO22847.1 - 0.0072 16.1 1.4 0.012 15.5 0.9 1.3 1 0 0 1 1 1 1 Tropomyosin like WEMBL PF05701.6 KOO22847.1 - 0.009 14.5 2.3 0.013 13.9 1.6 1.1 1 0 0 1 1 1 1 Weak chloroplast movement under blue light DUF812 PF05667.6 KOO22847.1 - 0.012 14.1 0.2 0.012 14.1 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Seryl_tRNA_N PF02403.17 KOO22847.1 - 0.014 15.4 2.1 0.025 14.6 1.5 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain MscS_porin PF12795.2 KOO22847.1 - 0.018 14.3 0.5 0.03 13.6 0.3 1.4 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain IncA PF04156.9 KOO22847.1 - 0.019 14.5 0.2 0.029 13.9 0.1 1.2 1 0 0 1 1 1 0 IncA protein HemX PF04375.9 KOO22847.1 - 0.029 12.9 0.4 0.043 12.3 0.3 1.2 1 0 0 1 1 1 0 HemX ALIX_LYPXL_bnd PF13949.1 KOO22847.1 - 0.034 13.1 1.5 0.047 12.6 1.1 1.2 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV Sigma70_ner PF04546.8 KOO22847.1 - 0.034 13.7 0.3 0.059 12.9 0.2 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region EzrA PF06160.7 KOO22847.1 - 0.04 12.0 0.9 0.055 11.6 0.6 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Nup54 PF13874.1 KOO22847.1 - 0.045 13.4 0.5 0.089 12.4 0.3 1.5 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Not3 PF04065.10 KOO22847.1 - 0.071 12.3 0.7 0.11 11.7 0.4 1.4 1 1 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component Atg14 PF10186.4 KOO22847.1 - 0.078 11.9 2.5 0.11 11.3 1.7 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Atx10homo_assoc PF09759.4 KOO22847.1 - 0.095 12.4 1.1 5.1 6.8 0.3 2.5 2 1 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain DUF3923 PF13061.1 KOO22847.1 - 0.12 12.2 0.1 17 5.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3923) SPARC_Ca_bdg PF10591.4 KOO22847.1 - 0.12 12.3 0.1 0.45 10.5 0.0 1.9 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region AAA_23 PF13476.1 KOO22847.1 - 0.14 12.4 0.6 0.17 12.1 0.4 1.2 1 0 0 1 1 1 0 AAA domain DUF16 PF01519.11 KOO22847.1 - 0.18 12.0 1.1 0.51 10.5 0.8 1.8 1 1 0 1 1 1 0 Protein of unknown function DUF16 BMFP PF04380.8 KOO22847.1 - 7.1 6.8 7.8 21 5.3 0.7 3.1 3 0 0 3 3 3 0 Membrane fusogenic activity Nol1_Nop2_Fmu PF01189.12 KOO22848.1 - 4e-42 144.5 0.0 5.1e-42 144.1 0.0 1.1 1 0 0 1 1 1 1 NOL1/NOP2/sun family Methyltransf_26 PF13659.1 KOO22848.1 - 1.2e-07 31.7 0.7 1.2e-07 31.7 0.5 1.8 2 0 0 2 2 2 1 Methyltransferase domain NusB PF01029.13 KOO22848.1 - 1.6e-05 24.9 0.0 2.6e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 NusB family FtsJ PF01728.14 KOO22848.1 - 2.2e-05 24.5 0.0 5.6e-05 23.2 0.0 1.6 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.1 KOO22848.1 - 0.00058 19.4 0.0 0.00085 18.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.5 KOO22848.1 - 0.011 15.2 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase PCMT PF01135.14 KOO22848.1 - 0.013 15.0 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Bile_Hydr_Trans PF04775.9 KOO22849.1 - 0.29 10.8 1.5 4.9 6.8 0.0 2.5 2 1 1 3 3 3 0 Acyl-CoA thioester hydrolase/BAAT N-terminal region DUF616 PF04765.8 KOO22850.1 - 3.5e-38 131.4 0.0 1.2e-37 129.7 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF616) EF-hand_6 PF13405.1 KOO22851.1 - 2.2e-08 33.2 0.0 0.00016 21.3 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO22851.1 - 1.2e-07 31.7 0.0 3.2e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO22851.1 - 4.1e-07 28.8 0.0 0.00034 19.6 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO22851.1 - 2e-06 27.2 0.0 0.0051 16.3 0.0 3.5 2 1 1 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO22851.1 - 6e-05 23.0 0.0 0.00012 22.0 0.0 1.5 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.1 KOO22851.1 - 0.00015 20.8 0.0 0.074 12.4 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.1 KOO22851.1 - 0.073 12.7 0.0 0.2 11.3 0.0 1.7 1 1 1 2 2 2 0 EF hand DUF3652 PF12372.3 KOO22851.1 - 0.12 12.0 0.9 0.38 10.3 0.1 2.3 2 0 0 2 2 2 0 Huntingtin protein region GSHPx PF00255.14 KOO22852.1 - 7.7e-23 79.9 0.0 1e-22 79.5 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase Thioredoxin PF00085.15 KOO22853.1 - 2.6e-18 65.6 0.0 3.2e-18 65.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 KOO22853.1 - 0.00054 20.0 0.0 0.0011 19.0 0.0 1.4 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 KOO22853.1 - 0.00096 19.3 0.0 0.0039 17.3 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.1 KOO22853.1 - 0.0082 16.1 0.1 0.05 13.6 0.0 2.1 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_4 PF13462.1 KOO22853.1 - 0.017 15.1 0.0 0.023 14.6 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin DUF164 PF02591.10 KOO22853.1 - 0.018 14.8 1.0 0.094 12.5 0.9 2.0 2 0 0 2 2 2 0 Putative zinc ribbon domain AhpC-TSA PF00578.16 KOO22853.1 - 0.03 14.0 0.0 0.035 13.7 0.0 1.1 1 0 0 1 1 1 0 AhpC/TSA family DUF4483 PF14825.1 KOO22854.1 - 0.033 13.8 9.0 0.11 12.0 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4483) ProSAAS PF07259.7 KOO22854.1 - 0.63 9.5 6.1 0.037 13.5 0.5 1.8 2 0 0 2 2 2 0 ProSAAS precursor Abhydrolase_5 PF12695.2 KOO22856.1 - 1.1e-22 80.3 0.0 2.2e-22 79.3 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO22856.1 - 6.2e-14 52.4 0.9 2.6e-12 47.1 0.6 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 KOO22856.1 - 5.8e-12 45.2 0.0 8.5e-12 44.7 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.15 KOO22856.1 - 0.00012 21.6 0.1 0.25 10.8 0.0 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 KOO22856.1 - 0.0006 19.3 0.0 0.39 10.1 0.0 2.2 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase BAAT_C PF08840.6 KOO22856.1 - 0.003 17.2 0.0 1.1 8.8 0.0 2.2 2 0 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Hydrolase_4 PF12146.3 KOO22856.1 - 0.0059 16.4 0.6 0.19 11.5 0.0 2.6 3 0 0 3 3 3 1 Putative lysophospholipase LIP PF03583.9 KOO22856.1 - 0.049 12.8 0.5 0.26 10.4 0.3 1.9 2 0 0 2 2 2 0 Secretory lipase DUF818 PF05677.7 KOO22856.1 - 0.083 11.6 0.1 0.12 11.0 0.1 1.1 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) DUF3089 PF11288.3 KOO22856.1 - 0.086 11.9 0.1 0.14 11.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) FSH1 PF03959.8 KOO22856.1 - 0.11 11.8 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Peptidase_S15 PF02129.13 KOO22856.1 - 0.13 11.6 0.0 0.27 10.6 0.0 1.5 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) EF-hand_7 PF13499.1 KOO22857.1 - 2.7e-10 40.2 0.9 4.4e-10 39.5 0.6 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO22857.1 - 5.5e-08 31.5 0.8 0.006 15.8 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO22857.1 - 1.3e-07 30.8 0.5 0.00028 20.5 0.0 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 KOO22857.1 - 1.3e-06 27.9 0.2 3.1e-06 26.7 0.1 1.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO22857.1 - 3e-05 23.1 0.6 0.00049 19.3 0.0 2.6 2 1 0 2 2 2 1 EF hand EF-hand_10 PF14788.1 KOO22857.1 - 0.05 13.2 0.4 0.23 11.1 0.0 2.1 1 1 1 2 2 2 0 EF hand EF-hand_6 PF13405.1 KOO22859.1 - 0.0013 18.4 0.2 0.25 11.3 0.0 2.7 1 1 1 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO22859.1 - 0.0088 15.2 0.0 5.7 6.5 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO22859.1 - 0.12 12.5 0.3 1.5 9.0 0.1 2.4 1 1 1 2 2 2 0 EF-hand domain pair DEAD PF00270.24 KOO22860.1 - 1.4e-36 125.5 0.0 4e-36 124.0 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO22860.1 - 4.9e-19 67.9 0.1 1.1e-18 66.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PCAF_N PF06466.6 KOO22860.1 - 0.0053 16.1 0.0 0.0082 15.4 0.0 1.3 1 0 0 1 1 1 1 PCAF (P300/CBP-associated factor) N-terminal domain DUF2868 PF11067.3 KOO22860.1 - 1.6 7.7 7.1 3.5 6.6 4.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) PKD_channel PF08016.7 KOO22863.1 - 4e-29 101.3 14.1 5.6e-26 90.9 12.1 2.2 2 0 0 2 2 2 2 Polycystin cation channel NPV_P10 PF05531.7 KOO22863.1 - 0.2 11.8 0.0 0.45 10.7 0.0 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF4577 PF15145.1 KOO22863.1 - 0.5 10.2 1.4 14 5.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) Miro PF08477.8 KOO22864.1 - 2.9e-05 24.5 0.0 0.0033 17.9 0.0 3.0 2 1 0 2 2 2 1 Miro-like protein IIGP PF05049.8 KOO22864.1 - 0.015 14.1 0.1 0.08 11.7 0.0 1.9 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) Mcm10 PF09332.6 KOO22865.1 - 3.5e-24 85.7 3.6 5.8e-24 85.0 2.5 1.3 1 0 0 1 1 1 1 Mcm10 replication factor zf-primase PF09329.6 KOO22865.1 - 1e-15 57.0 0.5 2.5e-15 55.8 0.3 1.6 1 0 0 1 1 1 1 Primase zinc finger MafB19-deam PF14437.1 KOO22865.1 - 0.12 12.0 0.5 0.48 10.0 0.2 2.1 2 0 0 2 2 2 0 MafB19-like deaminase GRASP55_65 PF04495.9 KOO22866.1 - 3e-46 156.8 0.0 6.6e-28 97.4 0.0 2.0 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.1 KOO22866.1 - 3.4e-05 23.6 0.1 0.035 13.9 0.0 2.2 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.19 KOO22866.1 - 0.0015 18.7 0.1 1.2 9.4 0.0 2.2 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) CofC PF01983.11 KOO22866.1 - 0.049 12.5 0.0 5.4 5.9 0.0 2.4 2 1 1 3 3 3 0 Guanylyl transferase CofC like tRNA-synt_2 PF00152.15 KOO22867.1 - 1.6e-78 263.8 0.0 2e-78 263.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 KOO22867.1 - 3.7e-07 29.8 0.0 6.2e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 KOO22867.1 - 0.002 17.3 0.2 0.21 10.7 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) 7TMR-DISMED2 PF07696.6 KOO22867.1 - 0.11 11.8 0.1 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 7TMR-DISM extracellular 2 UCH PF00443.24 KOO22868.1 - 1.3e-47 162.2 0.0 1.5e-47 161.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOO22868.1 - 1.7e-24 86.7 0.0 4.4e-24 85.4 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Galactosyl_T PF01762.16 KOO22869.1 - 2.4e-06 27.2 0.0 7.2e-06 25.7 0.0 1.8 2 0 0 2 2 2 1 Galactosyltransferase Ldl_recept_b PF00058.12 KOO22870.1 - 3.2e-07 30.5 0.1 0.0003 21.0 0.0 3.7 3 1 0 3 3 3 2 Low-density lipoprotein receptor repeat class B Acylphosphatase PF00708.13 KOO22871.1 - 5e-09 36.1 0.0 0.00027 20.9 0.0 2.9 2 1 1 3 3 3 2 Acylphosphatase IQ PF00612.22 KOO22874.1 - 0.14 11.8 1.9 0.5 10.1 1.3 2.0 1 0 0 1 1 1 0 IQ calmodulin-binding motif HAD PF12710.2 KOO22876.1 - 0.016 15.3 0.3 5.4 7.1 0.0 2.2 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase NIF PF03031.13 KOO22876.1 - 0.13 11.9 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 NLI interacting factor-like phosphatase PI3_PI4_kinase PF00454.22 KOO22877.1 - 1.8e-28 99.5 0.0 6.6e-28 97.7 0.0 1.8 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.15 KOO22877.1 - 0.061 12.4 0.0 0.13 11.4 0.0 1.5 1 0 0 1 1 1 0 Phosphoinositide 3-kinase family, accessory domain (PIK domain) tRNA-synt_1b PF00579.20 KOO22878.1 - 2e-48 165.0 0.0 1.1e-42 146.2 0.0 3.1 3 0 0 3 3 3 3 tRNA synthetases class I (W and Y) 2OG-FeII_Oxy_3 PF13640.1 KOO22879.1 - 5.7e-09 36.3 0.2 1.2e-08 35.3 0.2 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ShK PF01549.19 KOO22879.1 - 1.6e-07 31.5 10.7 1.6e-07 31.5 7.4 3.0 2 1 0 2 2 2 1 ShK domain-like 2OG-FeII_Oxy PF03171.15 KOO22879.1 - 3.5e-07 30.4 0.1 6e-07 29.6 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Sec23_trunk PF04811.10 KOO22881.1 - 1.5e-41 142.3 0.0 2.5e-41 141.6 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 KOO22881.1 - 1.1e-22 79.3 0.4 1.9e-22 78.6 0.3 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.10 KOO22881.1 - 6.9e-18 63.9 2.9 1.4e-17 62.9 2.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.7 KOO22881.1 - 1.3e-17 64.0 0.0 2.9e-17 62.9 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.17 KOO22881.1 - 1.9e-07 30.6 0.0 4.3e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat RRN7 PF11781.3 KOO22881.1 - 0.063 12.7 3.5 0.15 11.5 2.4 1.6 1 0 0 1 1 1 0 RNA polymerase I-specific transcription initiation factor Rrn7 ACT_6 PF13740.1 KOO22882.1 - 1.2e-08 34.5 0.0 1.3e-07 31.2 0.0 2.2 3 0 0 3 3 3 1 ACT domain ACT_4 PF13291.1 KOO22882.1 - 0.00027 21.1 0.0 0.25 11.6 0.0 2.2 2 0 0 2 2 2 2 ACT domain Exo_endo_phos PF03372.18 KOO22884.1 - 6e-18 65.6 0.6 7.4e-18 65.3 0.4 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SAP PF02037.22 KOO22884.1 - 2e-08 33.5 0.1 9.7e-08 31.3 0.1 2.1 2 0 0 2 2 2 1 SAP domain Exo_endo_phos_2 PF14529.1 KOO22884.1 - 1.2e-06 28.0 0.0 5.7e-06 25.9 0.0 2.2 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase GTP_EFTU PF00009.22 KOO22886.1 - 9e-32 110.0 0.0 3.4e-31 108.1 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 KOO22886.1 - 1.3e-16 60.3 2.2 1.6e-16 60.1 0.1 2.2 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 KOO22886.1 - 6.5e-10 38.9 5.7 1e-08 35.1 0.0 3.1 3 0 0 3 3 3 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 KOO22886.1 - 2.7e-06 27.3 0.1 9.8e-06 25.5 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.1 KOO22886.1 - 0.0018 18.2 2.4 0.012 15.5 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain ATP_bind_1 PF03029.12 KOO22886.1 - 0.004 16.7 0.0 0.023 14.2 0.0 2.2 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Ras PF00071.17 KOO22886.1 - 0.015 14.6 0.0 0.11 11.8 0.0 2.4 2 1 0 2 2 2 0 Ras family Miro PF08477.8 KOO22886.1 - 0.016 15.6 0.1 0.11 13.0 0.0 2.4 2 0 0 2 2 2 0 Miro-like protein GTP_EFTU_D4 PF14578.1 KOO22886.1 - 0.021 14.4 4.0 0.096 12.3 2.8 2.1 1 1 0 1 1 1 0 Elongation factor Tu domain 4 AAA_22 PF13401.1 KOO22886.1 - 0.023 14.8 0.4 0.13 12.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain SURF4 PF02077.10 KOO22887.1 - 1.9e-19 70.0 10.4 1.3e-09 37.8 0.3 3.3 3 1 0 3 3 3 3 SURF4 family DoxX PF07681.7 KOO22887.1 - 0.029 14.7 5.6 0.029 14.7 3.9 3.5 3 1 1 4 4 4 0 DoxX Exo_endo_phos PF03372.18 KOO22888.1 - 1.4e-26 93.9 0.0 1.8e-26 93.5 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Fasciclin PF02469.17 KOO22889.1 - 9.8e-72 238.9 0.1 1.5e-34 118.7 0.0 2.1 2 0 0 2 2 2 2 Fasciclin domain DLD PF14878.1 KOO22889.1 - 0.12 12.5 0.0 18 5.4 0.0 2.4 2 0 0 2 2 2 0 Death-like domain of SPT6 DUF211 PF02680.9 KOO22889.1 - 0.78 9.5 6.8 8.7 6.2 0.3 2.5 2 0 0 2 2 2 0 Uncharacterized ArCR, COG1888 PG_binding_4 PF12229.3 KOO22889.1 - 1.9 8.7 5.5 18 5.5 0.5 2.4 2 0 0 2 2 2 0 Putative peptidoglycan binding domain DUF4098 PF13345.1 KOO22889.1 - 5 7.1 10.3 5.8 6.9 0.9 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4098) Nucleotid_trans PF03407.11 KOO22890.1 - 8.9e-34 117.1 0.0 1.3e-33 116.5 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase DUF2094 PF09867.4 KOO22890.1 - 0.011 15.5 1.3 0.026 14.4 0.9 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2094) MSP1_C PF07462.6 KOO22890.1 - 0.51 8.6 0.8 0.92 7.8 0.6 1.3 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus tRNA_bind PF01588.15 KOO22891.1 - 3.3e-11 42.8 0.0 6.2e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain SAM_2 PF07647.12 KOO22891.1 - 0.0031 17.3 0.0 1.7 8.5 0.0 2.3 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) Glyco_transf_8 PF01501.15 KOO22892.1 - 1.9e-08 33.9 0.0 2.5e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.3 KOO22892.1 - 0.00011 21.6 0.0 0.00021 20.7 0.0 1.4 1 0 0 1 1 1 1 Mannosyltransferase putative Nucleotid_trans PF03407.11 KOO22892.1 - 0.048 13.4 0.1 0.073 12.8 0.1 1.3 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Ribosomal_L11_N PF03946.9 KOO22893.1 - 1.1e-25 88.8 0.0 1.8e-25 88.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 KOO22893.1 - 4.2e-25 87.6 0.0 6.5e-25 87.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain RabGAP-TBC PF00566.13 KOO22894.1 - 2.2e-45 154.7 0.0 3.1e-45 154.2 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain UBA_4 PF14555.1 KOO22894.1 - 4.5e-08 32.4 0.2 8.6e-08 31.5 0.1 1.5 1 0 0 1 1 1 1 UBA-like domain WWE PF02825.15 KOO22894.1 - 6.7e-08 31.8 0.0 6.7e-08 31.8 0.0 1.7 2 0 0 2 2 2 1 WWE domain TPR_11 PF13414.1 KOO22895.1 - 1e-07 31.4 8.5 3.7e-07 29.6 0.7 3.4 4 0 0 4 4 4 1 TPR repeat TPR_1 PF00515.23 KOO22895.1 - 0.0064 16.0 1.6 0.95 9.1 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO22895.1 - 0.1 12.9 8.1 0.46 10.8 0.6 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO22895.1 - 0.42 11.1 4.0 14 6.4 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Nop14 PF04147.7 KOO22895.1 - 0.56 8.0 16.0 0.69 7.7 11.1 1.2 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.7 KOO22895.1 - 0.97 8.6 17.1 1.4 8.1 11.8 1.2 1 0 0 1 1 1 0 SDA1 TPR_2 PF07719.12 KOO22895.1 - 1.4 9.0 13.9 3.8 7.6 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat Daxx PF03344.10 KOO22895.1 - 2.3 6.6 11.2 2.6 6.4 7.8 1.1 1 0 0 1 1 1 0 Daxx Family CDV3 PF15359.1 KOO22897.1 - 0.4 10.7 2.9 0.49 10.4 2.0 1.1 1 0 0 1 1 1 0 Carnitine deficiency-associated protein 3 zf-UBR PF02207.15 KOO22898.1 - 3.5e-18 65.0 12.6 6.2e-18 64.2 8.7 1.4 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Glyco_trans_1_4 PF13692.1 KOO22898.1 - 0.014 15.4 0.1 0.26 11.4 0.0 2.8 2 0 0 2 2 2 0 Glycosyl transferases group 1 Glyco_transf_8 PF01501.15 KOO22899.1 - 5.2e-07 29.2 0.0 2.1e-06 27.2 0.0 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 8 DUF647 PF04884.9 KOO22900.1 - 3.5e-52 177.0 0.3 4.8e-52 176.6 0.2 1.1 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis Mito_carr PF00153.22 KOO22901.1 - 1.2e-43 146.7 0.6 2.3e-16 59.2 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF1785 PF08699.5 KOO22901.1 - 0.058 12.7 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1785) UQ_con PF00179.21 KOO22903.1 - 9.7e-25 86.6 0.0 1.6e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Anthrax_toxA PF03497.11 KOO22904.1 - 0.002 18.0 0.0 0.0029 17.4 0.0 1.3 1 0 0 1 1 1 1 Anthrax toxin LF subunit cNMP_binding PF00027.24 KOO22905.1 - 9e-21 73.4 0.1 1.2e-20 73.1 0.1 1.2 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain EF-hand_1 PF00036.27 KOO22905.1 - 0.00068 18.7 2.1 0.00074 18.6 0.3 2.1 2 1 1 3 3 3 1 EF hand EF-hand_6 PF13405.1 KOO22905.1 - 0.0022 17.7 0.8 0.0063 16.3 0.6 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.1 KOO22905.1 - 0.003 16.8 0.1 0.0086 15.3 0.1 1.8 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 KOO22905.1 - 0.0057 16.2 0.4 0.014 14.9 0.3 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.1 KOO22905.1 - 0.0072 16.4 0.4 0.017 15.2 0.3 1.6 1 0 0 1 1 1 1 EF-hand domain pair DUF3954 PF13128.1 KOO22905.1 - 0.057 12.8 0.3 0.13 11.7 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3954) Radical_SAM PF04055.16 KOO22907.1 - 1.2e-13 51.5 0.0 3.3e-13 50.1 0.0 1.7 1 0 0 1 1 1 1 Radical SAM superfamily Acetyltransf_1 PF00583.19 KOO22907.1 - 1.5e-09 37.7 2.4 3.3e-07 30.2 1.3 3.4 3 0 0 3 3 3 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 KOO22907.1 - 0.0043 17.1 0.1 0.02 15.0 0.1 2.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 KOO22907.1 - 0.021 14.9 0.0 0.4 10.8 0.1 2.5 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Anoctamin PF04547.7 KOO22908.1 - 6.9e-91 305.1 2.3 5.6e-57 193.3 0.0 2.1 1 1 1 2 2 2 2 Calcium-activated chloride channel Ank_2 PF12796.2 KOO22909.1 - 1.2e-27 96.0 21.8 3.7e-08 33.6 0.5 4.2 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO22909.1 - 7.2e-27 92.8 12.9 0.00011 22.3 0.0 7.7 1 1 7 8 8 8 8 Ankyrin repeats (many copies) Ank PF00023.25 KOO22909.1 - 4.9e-17 60.8 15.9 0.02 14.6 0.0 7.8 8 0 0 8 8 8 5 Ankyrin repeat Ank_3 PF13606.1 KOO22909.1 - 2.7e-14 51.8 13.5 0.23 11.8 0.0 7.8 8 0 0 8 8 8 5 Ankyrin repeat Ank_4 PF13637.1 KOO22909.1 - 3.6e-11 43.2 6.1 0.014 15.9 0.1 4.9 4 1 1 5 5 5 3 Ankyrin repeats (many copies) DUF3349 PF11829.3 KOO22909.1 - 7.5e-10 39.1 0.2 2.7 8.4 0.0 7.0 6 1 1 7 7 7 1 Protein of unknown function (DUF3349) DUF2251 PF10008.4 KOO22909.1 - 0.018 15.1 0.6 3.1 7.9 0.0 3.3 1 1 3 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2251) DUF3223 PF11523.3 KOO22909.1 - 0.024 14.9 0.6 50 4.2 0.0 5.0 4 2 2 6 6 6 0 Protein of unknown function (DUF3223) DUF976 PF06162.7 KOO22909.1 - 0.04 13.4 0.0 8.4 5.8 0.0 3.4 2 2 3 5 5 5 0 Caenorhabditis elegans protein of unknown function (DUF976) AMNp_N PF10423.4 KOO22909.1 - 0.075 12.6 0.1 2.9 7.4 0.0 3.3 3 2 0 3 3 3 0 Bacterial AMP nucleoside phosphorylase N-terminus DUF2877 PF11392.3 KOO22909.1 - 0.21 11.8 0.7 9 6.5 0.1 2.7 2 2 0 2 2 2 0 Protein of unknown function (DUF2877) HMG-CoA_red PF00368.13 KOO22910.1 - 1.1e-130 435.6 11.7 1.4e-70 237.8 0.0 2.0 1 1 1 2 2 2 2 Hydroxymethylglutaryl-coenzyme A reductase SSI PF00720.12 KOO22910.1 - 1 9.2 7.0 1 9.3 0.1 3.6 3 1 1 4 4 4 0 Subtilisin inhibitor-like Ion_trans PF00520.26 KOO22911.1 - 4e-110 365.7 64.7 3.3e-35 121.1 5.4 5.5 5 0 0 5 5 5 5 Ion transport protein EF-hand_1 PF00036.27 KOO22911.1 - 6.3e-27 90.8 7.2 5.7e-05 22.1 0.1 6.7 7 0 0 7 7 7 5 EF hand EF-hand_7 PF13499.1 KOO22911.1 - 1.6e-23 82.6 11.6 4.3e-09 36.3 0.7 3.9 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO22911.1 - 1e-20 71.6 18.7 4.2e-05 23.0 0.3 7.3 8 0 0 8 8 8 5 EF-hand domain EF-hand_5 PF13202.1 KOO22911.1 - 6.7e-19 66.3 11.8 4.1e-05 22.7 0.1 5.0 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO22911.1 - 1.3e-10 40.6 10.8 2.9e-06 26.7 0.4 5.0 4 1 1 5 5 5 3 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO22911.1 - 8.1e-09 35.5 1.3 0.00038 20.4 0.0 3.6 4 0 0 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region PKD_channel PF08016.7 KOO22911.1 - 0.00021 19.8 7.0 0.00021 19.8 4.9 8.4 8 2 0 8 8 8 3 Polycystin cation channel EF-hand_9 PF14658.1 KOO22911.1 - 0.17 11.8 0.4 1.6 8.7 0.0 2.8 3 0 0 3 3 3 0 EF-hand domain Pyr_redox_2 PF07992.9 KOO22912.1 - 2.9e-14 53.4 0.0 5.4e-14 52.5 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOO22912.1 - 8.5e-08 32.4 1.9 0.00025 21.3 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOO22912.1 - 7e-07 29.5 3.2 4.2e-06 26.9 0.0 2.7 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 KOO22912.1 - 1.7e-05 23.9 4.4 0.028 13.3 0.0 2.5 2 1 0 2 2 2 2 FAD dependent oxidoreductase K_oxygenase PF13434.1 KOO22912.1 - 5.7e-05 22.1 1.5 0.00024 20.1 0.1 2.5 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.9 KOO22912.1 - 0.00033 19.4 4.5 0.015 13.9 0.6 2.2 2 0 0 2 2 2 2 Tryptophan halogenase NAD_binding_9 PF13454.1 KOO22912.1 - 0.00057 19.6 2.6 0.34 10.6 0.0 2.9 3 0 0 3 3 3 2 FAD-NAD(P)-binding Lycopene_cycl PF05834.7 KOO22912.1 - 0.0023 16.9 0.7 1.3 7.8 0.2 2.6 2 1 1 3 3 3 2 Lycopene cyclase protein NAD_binding_8 PF13450.1 KOO22912.1 - 0.0045 16.9 1.6 0.79 9.7 0.3 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 KOO22912.1 - 3.3 6.6 6.3 3.5 6.5 1.1 2.3 2 0 0 2 2 2 0 FAD binding domain Methyltransf_25 PF13649.1 KOO22913.1 - 4.1e-09 36.6 0.0 1.1e-08 35.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO22913.1 - 1e-07 32.3 0.0 8.5e-07 29.3 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO22913.1 - 1.8e-07 31.0 0.0 4.4e-06 26.5 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO22913.1 - 1.6e-06 28.4 0.0 4.6e-06 27.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO22913.1 - 4.8e-06 27.1 0.0 1.4e-05 25.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO22913.1 - 5.6e-06 26.0 0.0 1e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain TPMT PF05724.6 KOO22913.1 - 0.021 14.2 0.0 0.045 13.1 0.0 1.5 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) CMAS PF02353.15 KOO22913.1 - 0.024 13.7 0.0 0.043 12.9 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase CheR PF01739.13 KOO22913.1 - 0.078 12.2 0.0 0.33 10.2 0.0 1.9 1 1 0 1 1 1 0 CheR methyltransferase, SAM binding domain MTS PF05175.9 KOO22913.1 - 0.17 11.2 0.6 0.61 9.4 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase small domain Pkinase PF00069.20 KOO22915.1 - 2.2e-45 154.8 0.0 6.2e-44 150.1 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22915.1 - 4e-22 78.5 0.0 7.6e-22 77.6 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase fn3 PF00041.16 KOO22917.1 - 2.9e-09 36.9 0.0 5.3e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain TPR_11 PF13414.1 KOO22917.1 - 3.2e-07 29.8 0.1 0.0015 18.1 0.0 2.6 1 1 2 3 3 3 3 TPR repeat TPR_2 PF07719.12 KOO22917.1 - 5.2e-05 22.8 0.0 0.046 13.6 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO22917.1 - 0.0041 16.6 0.0 3.4 7.4 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO22917.1 - 0.011 15.9 0.0 25 5.3 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 KOO22917.1 - 0.018 15.6 0.0 0.038 14.6 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_20 PF14561.1 KOO22917.1 - 0.051 13.6 0.3 0.27 11.3 0.1 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat Interfer-bind PF09294.5 KOO22917.1 - 0.091 12.8 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Interferon-alpha/beta receptor, fibronectin type III PK_C PF02887.11 KOO22919.1 - 3.8e-22 78.0 0.2 4.9e-22 77.6 0.1 1.1 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain APH PF01636.18 KOO22920.1 - 8.9e-18 64.8 4.8 8.9e-18 64.8 3.3 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.20 KOO22921.1 - 7.7e-35 120.2 0.0 1.1e-34 119.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22921.1 - 5.3e-16 58.4 0.0 1.1e-15 57.4 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase DnaJ PF00226.26 KOO22921.1 - 4.2e-05 23.1 0.0 8.8e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain Kdo PF06293.9 KOO22921.1 - 0.0036 16.3 0.2 0.0062 15.6 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Nop16 PF09420.5 KOO22922.1 - 1.5e-19 70.6 0.1 3.5e-19 69.4 0.1 1.6 1 1 0 1 1 1 1 Ribosome biogenesis protein Nop16 UPF0029 PF01205.14 KOO22923.1 - 2.3e-23 81.9 0.5 6.5e-23 80.5 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized protein family UPF0029 RWD PF05773.17 KOO22923.1 - 0.0012 18.6 0.0 0.0048 16.7 0.0 1.9 1 1 0 1 1 1 1 RWD domain Glyco_transf_8 PF01501.15 KOO22923.1 - 0.016 14.5 0.0 0.03 13.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 8 DUF1663 PF07909.6 KOO22923.1 - 0.022 13.3 0.6 0.03 12.8 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1663) BHD_3 PF10405.4 KOO22924.1 - 0.0012 18.5 0.0 0.0016 18.0 0.0 1.2 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BTAD PF03704.12 KOO22924.1 - 0.0058 16.9 2.7 0.0066 16.7 1.8 1.0 1 0 0 1 1 1 1 Bacterial transcriptional activator domain DUF1470 PF07336.6 KOO22924.1 - 0.022 15.0 1.9 0.023 15.0 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1470) Phage_GPL PF05926.6 KOO22924.1 - 0.059 13.2 0.5 0.065 13.0 0.3 1.1 1 0 0 1 1 1 0 Phage head completion protein (GPL) Acetyltransf_6 PF13480.1 KOO22924.1 - 0.066 13.1 0.8 0.075 12.9 0.6 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF501 PF04417.7 KOO22924.1 - 0.075 12.8 1.0 0.087 12.6 0.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF501) Transpep_BrtH PF14399.1 KOO22924.1 - 0.1 11.8 0.7 0.11 11.7 0.5 1.1 1 0 0 1 1 1 0 NlpC/p60-like transpeptidase CSS-motif PF12792.2 KOO22924.1 - 0.16 11.2 0.8 0.2 10.9 0.5 1.1 1 0 0 1 1 1 0 CSS motif domain associated with EAL Ldh_1_C PF02866.13 KOO22925.1 - 3.6e-38 131.0 0.1 7.5e-38 129.9 0.0 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.18 KOO22925.1 - 1e-29 103.1 0.1 1.7e-29 102.4 0.1 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Pkinase PF00069.20 KOO22926.1 - 1e-48 165.7 0.0 1.4e-48 165.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO22926.1 - 3.2e-27 95.2 0.0 4e-27 94.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO22926.1 - 0.004 16.9 0.1 1.9 8.1 0.0 3.1 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.9 KOO22926.1 - 0.025 13.6 0.0 0.042 12.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-TFIIB PF13453.1 KOO22926.1 - 0.051 12.7 0.3 0.15 11.2 0.2 1.8 1 0 0 1 1 1 0 Transcription factor zinc-finger CBF PF03914.12 KOO22926.1 - 0.11 11.8 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 CBF/Mak21 family peroxidase PF00141.18 KOO22927.1 - 9.6e-48 162.6 0.0 1.9e-47 161.6 0.0 1.4 1 1 0 1 1 1 1 Peroxidase SPOUT_MTase_2 PF14419.1 KOO22928.1 - 0.031 13.4 0.1 0.058 12.5 0.0 1.4 1 0 0 1 1 1 0 AF2226-like SPOUT RNA Methylase fused to THUMP DUF848 PF05852.6 KOO22928.1 - 0.24 11.2 2.0 0.37 10.6 0.3 1.9 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Myosin_tail_1 PF01576.14 KOO22928.1 - 0.97 7.0 5.1 0.78 7.3 1.0 1.9 2 0 0 2 2 2 0 Myosin tail DUF4231 PF14015.1 KOO22928.1 - 1.7 8.6 10.7 3.8 7.5 3.8 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF4231) MT0933_antitox PF14013.1 KOO22928.1 - 2 8.5 7.3 4.5 7.4 5.1 1.5 1 0 0 1 1 1 0 MT0933-like antitoxin protein Ank_2 PF12796.2 KOO22929.1 - 9.7e-23 80.3 3.1 3.2e-15 56.2 0.4 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO22929.1 - 1.1e-17 63.6 4.8 2.3e-06 27.6 0.1 3.9 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO22929.1 - 1.1e-16 60.8 2.4 0.00015 22.1 0.1 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO22929.1 - 1e-15 56.6 9.1 7.1e-06 25.5 0.2 5.0 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.1 KOO22929.1 - 6.1e-13 47.6 4.0 0.0031 17.5 0.1 5.0 5 1 0 5 5 5 3 Ankyrin repeat GlnE PF03710.10 KOO22931.1 - 0.012 14.8 0.3 0.018 14.3 0.2 1.2 1 0 0 1 1 1 0 Glutamate-ammonia ligase adenylyltransferase PRP1_N PF06424.7 KOO22931.1 - 2.1 8.7 17.5 46 4.3 12.1 2.7 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal fn3 PF00041.16 KOO22932.1 - 3.6e-09 36.6 0.0 6.8e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain EF-hand_1 PF00036.27 KOO22932.1 - 5.3e-08 31.6 0.1 5e-07 28.5 0.1 2.5 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO22932.1 - 2.3e-05 24.4 0.0 9.4e-05 22.4 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO22932.1 - 2.9e-05 23.1 0.2 0.0001 21.4 0.1 1.9 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 KOO22932.1 - 3e-05 23.5 0.8 0.00036 20.0 0.0 3.0 4 0 0 4 4 4 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO22932.1 - 7.8e-05 22.2 0.3 0.011 15.5 0.1 3.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_4 PF12763.2 KOO22932.1 - 0.077 12.7 0.0 0.2 11.3 0.0 1.6 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand ATP_bind_3 PF01171.15 KOO22933.1 - 2.8e-34 118.1 0.0 4.5e-34 117.5 0.0 1.3 1 0 0 1 1 1 1 PP-loop family QueC PF06508.8 KOO22933.1 - 0.001 18.4 0.1 0.0032 16.7 0.1 1.7 1 1 1 2 2 2 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.16 KOO22933.1 - 0.0051 16.3 0.0 0.0095 15.4 0.0 1.4 1 0 0 1 1 1 1 Asparagine synthase Methyltransf_28 PF02636.12 KOO22935.1 - 7.1e-23 81.2 0.0 3.5e-22 79.0 0.0 2.1 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Rsm22 PF09243.5 KOO22936.1 - 2e-17 63.1 0.0 4.1e-17 62.1 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 Hydrolase_like PF13242.1 KOO22936.1 - 4.6e-13 48.6 0.0 1.4e-12 47.1 0.0 1.9 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.1 KOO22936.1 - 2.1e-08 33.9 0.0 4.5e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 KOO22936.1 - 0.0046 17.2 2.3 0.009 16.2 0.0 2.6 3 1 1 4 4 4 1 Haloacid dehalogenase-like hydrolase DUF4143 PF13635.1 KOO22936.1 - 0.16 12.1 0.0 2.1 8.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4143) BRE1 PF08647.6 KOO22937.1 - 0.038 13.9 0.4 0.066 13.1 0.2 1.4 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase Coatomer_E PF04733.9 KOO22937.1 - 0.06 12.5 2.8 0.066 12.3 2.0 1.1 1 0 0 1 1 1 0 Coatomer epsilon subunit DUF3186 PF11382.3 KOO22937.1 - 0.078 12.0 3.8 0.086 11.9 2.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3186) 2-Hacid_dh PF00389.25 KOO22937.1 - 2 7.8 4.1 7.3 6.0 2.9 1.7 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain RCC1 PF00415.13 KOO22938.1 - 9.3e-49 163.4 25.4 4.7e-13 49.1 0.3 7.9 7 2 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO22938.1 - 4.5e-17 61.1 44.0 1e-05 24.9 0.7 7.3 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat TauE PF01925.14 KOO22939.1 - 2.6e-11 43.4 20.8 4e-11 42.8 14.4 1.2 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE URO-D PF01208.12 KOO22940.1 - 2.7e-101 338.9 0.1 3.2e-101 338.6 0.0 1.1 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) BNR_2 PF13088.1 KOO22942.1 - 8e-26 90.9 0.1 1.1e-25 90.4 0.1 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 KOO22942.1 - 3.6e-07 29.5 0.0 8e-06 25.1 0.0 2.1 2 0 0 2 2 2 1 BNR repeat-like domain BNR PF02012.15 KOO22942.1 - 0.0015 18.0 28.5 0.082 12.7 0.3 5.6 5 0 0 5 5 5 4 BNR/Asp-box repeat DUF4185 PF13810.1 KOO22942.1 - 0.021 13.7 0.1 0.081 11.8 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4185) Beta_helix PF13229.1 KOO22943.1 - 2.2e-13 50.2 0.5 3.5e-13 49.6 0.4 1.3 1 0 0 1 1 1 1 Right handed beta helix region NosD PF05048.8 KOO22943.1 - 6.4e-07 28.7 0.0 8.1e-07 28.4 0.0 1.2 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) DUF1565 PF07602.6 KOO22943.1 - 0.031 13.4 0.0 1.4 8.0 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1565) CS PF04969.11 KOO22944.1 - 1.5e-06 28.6 0.0 1.9e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 CS domain Cytotoxic PF09000.5 KOO22944.1 - 0.026 14.5 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 Cytotoxic DNA_pol_B_thumb PF14791.1 KOO22945.1 - 0.00063 19.3 0.0 0.0025 17.4 0.0 2.1 2 0 0 2 2 2 1 DNA polymerase beta thumb Kinesin PF00225.18 KOO22946.1 - 7.3e-79 264.8 0.0 1e-78 264.3 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain FG-GAP PF01839.18 KOO22946.1 - 1.1e-14 53.6 14.9 0.00078 19.0 0.8 6.0 5 0 0 5 5 5 4 FG-GAP repeat VCBS PF13517.1 KOO22946.1 - 3e-13 49.9 8.0 0.0015 18.8 2.4 5.6 3 1 1 5 5 5 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella PQQ_2 PF13360.1 KOO22946.1 - 6.4e-08 32.3 9.9 6e-06 25.9 2.1 3.0 2 1 1 3 3 3 2 PQQ-like domain PQQ PF01011.16 KOO22946.1 - 7.3e-07 28.4 0.4 0.071 12.6 0.0 4.5 3 0 0 3 3 3 2 PQQ enzyme repeat PQQ_3 PF13570.1 KOO22946.1 - 0.001 19.2 18.5 2.1 8.7 0.3 6.7 6 0 0 6 6 6 3 PQQ-like domain TcdB_toxin_midN PF12256.3 KOO22946.1 - 0.0048 16.3 4.9 21 4.4 0.1 4.4 3 1 1 4 4 4 0 Insecticide toxin TcdB middle/N-terminal region UvrD-helicase PF00580.16 KOO22947.1 - 1.1e-67 228.5 0.0 1.6e-67 228.0 0.0 1.2 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.1 KOO22947.1 - 5e-54 184.0 0.0 1.4e-49 169.4 0.0 2.5 2 1 0 2 2 2 2 UvrD-like helicase C-terminal domain SRF-TF PF00319.13 KOO22947.1 - 6.6e-18 63.6 0.1 1.2e-17 62.8 0.1 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) AAA_19 PF13245.1 KOO22947.1 - 2.8e-15 55.8 5.3 4.4e-15 55.1 2.2 2.6 2 0 0 2 2 2 1 Part of AAA domain UvrD_C_2 PF13538.1 KOO22947.1 - 1e-11 44.8 0.0 5.9e-11 42.4 0.0 2.1 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_12 PF13087.1 KOO22947.1 - 0.00017 20.9 0.0 0.0007 19.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 KOO22947.1 - 0.00028 20.5 0.1 0.00071 19.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 KOO22947.1 - 0.00046 19.7 0.3 0.023 14.1 0.0 2.8 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase p450 PF00067.17 KOO22948.1 - 2e-11 43.1 0.2 9.6e-10 37.5 0.3 2.0 2 0 0 2 2 2 2 Cytochrome P450 Ras PF00071.17 KOO22949.1 - 0.09 12.1 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Ras family Steroid_dh PF02544.11 KOO22951.1 - 1.1e-35 122.5 0.1 1.3e-35 122.3 0.0 1.0 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.7 KOO22951.1 - 0.0091 15.3 0.0 0.01 15.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.8 KOO22951.1 - 0.053 13.6 1.1 0.08 13.0 0.8 1.4 1 1 0 1 1 1 0 Phospholipid methyltransferase EF-hand_1 PF00036.27 KOO22954.1 - 1e-25 87.0 6.2 4.1e-05 22.5 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO22954.1 - 8.1e-23 78.2 4.3 8.2e-05 22.1 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO22954.1 - 1.5e-22 77.8 2.4 2.8e-05 23.2 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO22954.1 - 4e-20 71.7 4.5 5.8e-10 39.1 0.4 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO22954.1 - 1.1e-16 60.1 10.6 6.5e-06 25.6 1.2 3.9 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO22954.1 - 7.2e-05 22.7 0.9 0.24 11.4 0.0 3.2 2 1 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region RAP PF08373.5 KOO22955.1 - 6.3e-13 48.3 0.0 3.7e-12 45.8 0.0 2.2 2 0 0 2 2 2 1 RAP domain FAST_1 PF06743.10 KOO22955.1 - 0.025 14.2 2.3 0.052 13.2 0.0 2.8 3 1 0 3 3 3 0 FAST kinase-like protein, subdomain 1 NHL PF01436.16 KOO22956.1 - 2.8e-12 45.9 2.4 0.048 13.6 0.0 5.4 6 0 0 6 6 6 3 NHL repeat SGL PF08450.7 KOO22956.1 - 1.1e-09 38.0 0.0 0.077 12.3 0.0 4.1 2 2 2 4 4 4 4 SMP-30/Gluconolaconase/LRE-like region SdiA-regulated PF06977.6 KOO22956.1 - 0.0032 16.4 0.0 0.45 9.4 0.0 2.2 2 0 0 2 2 2 2 SdiA-regulated Reg_prop PF07494.6 KOO22956.1 - 0.12 12.4 0.0 7.9 6.8 0.0 2.9 2 0 0 2 2 2 0 Two component regulator propeller VPS9 PF02204.13 KOO22957.1 - 0.01 15.8 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 Vacuolar sorting protein 9 (VPS9) domain Asp PF00026.18 KOO22959.1 - 4.9e-29 101.5 0.0 1.6e-28 99.8 0.0 1.8 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 KOO22959.1 - 6e-06 26.3 0.2 1.3e-05 25.1 0.0 1.7 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal DUF3359 PF11839.3 KOO22960.1 - 0.025 14.9 5.2 0.028 14.7 3.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3359) DUF4140 PF13600.1 KOO22960.1 - 0.099 13.1 1.7 0.12 12.7 1.2 1.2 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) PTS_IIA PF02255.11 KOO22960.1 - 0.33 10.8 2.3 0.44 10.4 1.6 1.2 1 0 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIA subunit Methyltransf_24 PF13578.1 KOO22962.1 - 5.1e-10 40.1 2.0 5.4e-10 40.0 0.2 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_3 PF01596.12 KOO22962.1 - 3.1e-08 32.9 0.0 3.9e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Nuc_sug_transp PF04142.10 KOO22963.1 - 5.2e-25 87.9 3.3 6.2e-25 87.7 2.3 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter DUF4079 PF13301.1 KOO22963.1 - 0.016 15.2 1.1 0.021 14.8 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4079) UAA PF08449.6 KOO22963.1 - 0.04 12.8 0.9 0.043 12.7 0.6 1.2 1 0 0 1 1 1 0 UAA transporter family Kinesin PF00225.18 KOO22964.1 - 1.2e-83 280.5 0.0 1.5e-83 280.3 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain HALZ PF02183.13 KOO22964.1 - 0.00096 18.8 7.3 0.69 9.6 0.1 4.0 3 1 1 4 4 4 2 Homeobox associated leucine zipper bZIP_1 PF00170.16 KOO22964.1 - 0.32 10.9 5.4 3 7.8 0.1 3.3 3 0 0 3 3 3 0 bZIP transcription factor Mto2_bdg PF12808.2 KOO22964.1 - 0.76 9.9 4.5 46 4.2 0.1 3.7 3 0 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DivIC PF04977.10 KOO22964.1 - 1 8.8 13.2 0.78 9.2 0.1 3.5 3 0 0 3 3 3 0 Septum formation initiator DUF972 PF06156.8 KOO22964.1 - 2.3 8.6 6.7 7.2 7.0 0.1 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF972) TMF_TATA_bd PF12325.3 KOO22964.1 - 2.8 7.7 8.4 7.8 6.2 0.1 3.3 2 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF4200 PF13863.1 KOO22964.1 - 3 7.7 8.7 2.8 7.8 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) Adeno_PIX PF03955.9 KOO22964.1 - 3.8 8.0 7.9 1.7 9.1 0.3 3.3 3 0 0 3 3 3 0 Adenovirus hexon-associated protein (IX) Methyltransf_11 PF08241.7 KOO22965.1 - 1e-12 48.3 0.0 2.3e-12 47.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO22965.1 - 4.8e-08 32.8 0.0 7.5e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO22965.1 - 7.6e-05 23.0 0.0 0.00017 21.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO22965.1 - 0.00019 20.6 0.0 0.00044 19.4 0.0 1.5 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 KOO22965.1 - 0.00023 20.7 0.0 0.00037 20.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO22965.1 - 0.00052 20.4 0.0 0.001 19.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 KOO22965.1 - 0.016 14.8 0.0 0.027 14.1 0.0 1.3 1 0 0 1 1 1 0 Hypothetical methyltransferase CMAS PF02353.15 KOO22965.1 - 0.019 14.0 0.0 0.034 13.2 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase DUF4538 PF15061.1 KOO22965.1 - 0.046 13.0 0.0 0.096 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) Methyltransf_18 PF12847.2 KOO22965.1 - 0.1 13.1 0.0 0.19 12.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_29 PF03141.11 KOO22965.1 - 0.18 10.0 0.0 0.25 9.6 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase CAP_N PF01213.14 KOO22965.1 - 0.97 8.6 2.6 1.6 7.9 1.8 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal S1 PF00575.18 KOO22966.1 - 8.7e-07 28.9 0.2 1.3e-06 28.4 0.2 1.3 1 0 0 1 1 1 1 S1 RNA binding domain UQ_con PF00179.21 KOO22967.1 - 7.8e-34 116.0 0.0 9e-34 115.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Bestrophin PF01062.16 KOO22968.1 - 1.7e-27 96.1 0.7 9.1e-27 93.7 0.5 1.9 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel ADH_zinc_N_2 PF13602.1 KOO22969.1 - 2.3e-10 41.4 0.5 6.1e-10 40.0 0.1 1.9 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 KOO22969.1 - 2.2e-09 36.9 0.3 8.8e-09 35.0 0.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Eno-Rase_NADH_b PF12242.3 KOO22969.1 - 0.00062 19.5 2.2 0.041 13.6 0.3 2.5 2 0 0 2 2 2 2 NAD(P)H binding domain of trans-2-enoyl-CoA reductase AlaDh_PNT_C PF01262.16 KOO22969.1 - 0.069 12.7 0.4 0.11 12.0 0.2 1.4 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_10 PF13460.1 KOO22969.1 - 0.11 12.5 1.3 0.21 11.6 0.9 1.5 1 1 0 1 1 1 0 NADH(P)-binding Arm PF00514.18 KOO22970.1 - 7.4e-05 22.4 7.5 0.069 13.0 0.1 3.8 3 0 0 3 3 3 3 Armadillo/beta-catenin-like repeat Kinesin PF00225.18 KOO22971.1 - 2.8e-44 151.1 0.0 4.3e-44 150.5 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain IQ PF00612.22 KOO22971.1 - 3.9e-08 32.2 29.9 0.033 13.8 0.8 6.6 6 0 0 6 6 6 5 IQ calmodulin-binding motif EF-hand_6 PF13405.1 KOO22971.1 - 0.00091 18.9 2.0 0.019 14.8 0.3 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.1 KOO22971.1 - 0.0015 18.5 1.3 0.0039 17.2 0.9 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO22971.1 - 0.18 11.2 2.2 0.3 10.5 0.4 2.2 2 0 0 2 2 2 0 EF hand EF-hand_5 PF13202.1 KOO22971.1 - 0.31 10.4 0.7 16 5.0 0.0 2.6 2 0 0 2 2 2 0 EF hand Nuc_sug_transp PF04142.10 KOO22972.1 - 1.5e-63 214.2 1.4 2.2e-63 213.6 1.0 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter TPT PF03151.11 KOO22972.1 - 1.8e-08 34.1 12.9 8.1e-08 32.0 2.7 2.7 2 1 0 2 2 2 2 Triose-phosphate Transporter family UAA PF08449.6 KOO22972.1 - 2.9e-08 32.9 4.3 5.4e-08 32.1 2.8 1.6 2 0 0 2 2 2 1 UAA transporter family EmrE PF13536.1 KOO22972.1 - 1.1e-07 32.0 1.2 1.1e-07 32.0 0.8 3.2 2 1 1 3 3 3 1 Multidrug resistance efflux transporter EamA PF00892.15 KOO22972.1 - 4.6e-07 29.9 2.4 4.6e-07 29.9 1.6 3.0 2 1 0 2 2 2 1 EamA-like transporter family Sugar_transport PF06800.7 KOO22972.1 - 0.0056 15.7 3.9 0.072 12.1 0.1 2.5 2 0 0 2 2 2 2 Sugar transport protein Ribosomal_L1 PF00687.16 KOO22974.1 - 7e-45 153.0 2.3 8.3e-45 152.8 1.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family CIAPIN1 PF05093.8 KOO22974.1 - 0.03 14.4 0.0 0.096 12.7 0.0 1.9 2 0 0 2 2 2 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Tubulin PF00091.20 KOO22975.1 - 3.4e-35 121.8 1.1 8.4e-35 120.5 0.8 1.6 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain FtsZ_C PF12327.3 KOO22975.1 - 6e-32 109.5 0.7 6e-32 109.5 0.5 2.1 2 0 0 2 2 2 1 FtsZ family, C-terminal domain Tubulin_2 PF13809.1 KOO22975.1 - 0.0027 16.7 5.3 0.038 12.9 1.1 2.2 1 1 0 2 2 2 2 Tubulin like AAA_16 PF13191.1 KOO22977.1 - 0.074 13.0 0.0 3.8 7.4 0.0 2.5 2 1 1 3 3 3 0 AAA ATPase domain Ribosomal_S9 PF00380.14 KOO22978.1 - 6.9e-37 126.3 0.3 8e-37 126.1 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 HEAT_2 PF13646.1 KOO22979.1 - 9.8e-36 121.9 97.8 1.2e-10 41.5 0.5 18.7 10 5 5 15 15 14 10 HEAT repeats HEAT PF02985.17 KOO22979.1 - 3.1e-35 117.0 44.3 0.00014 21.6 0.0 20.1 21 0 0 21 21 19 8 HEAT repeat HEAT_EZ PF13513.1 KOO22979.1 - 1.5e-24 85.7 136.0 1.4e-06 28.5 0.0 26.7 20 6 8 28 28 26 12 HEAT-like repeat DUF3554 PF12074.3 KOO22979.1 - 1.5e-15 57.5 6.0 1.8e-13 50.6 0.0 4.6 5 0 0 5 5 5 1 Domain of unknown function (DUF3554) CLASP_N PF12348.3 KOO22979.1 - 6.8e-14 51.7 0.0 0.031 13.6 0.0 6.4 6 1 1 7 7 7 4 CLASP N terminal Vac14_Fab1_bd PF12755.2 KOO22979.1 - 2.9e-12 46.8 0.0 0.26 11.7 0.0 7.5 8 2 1 9 9 7 3 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.15 KOO22979.1 - 5.2e-12 44.8 0.1 0.038 12.3 0.0 6.6 8 1 0 8 8 8 3 Adaptin N terminal region Cnd1 PF12717.2 KOO22979.1 - 6.1e-12 45.7 0.0 0.011 15.5 0.0 7.3 5 3 1 6 6 6 3 non-SMC mitotic condensation complex subunit 1 Ipi1_N PF12333.3 KOO22979.1 - 2.1e-07 30.8 2.1 9 6.3 0.1 8.7 9 0 0 9 9 9 1 Rix1 complex component involved in 60S ribosome maturation ParcG PF10274.4 KOO22979.1 - 1.7e-06 28.0 0.1 0.83 9.5 0.0 5.4 2 2 4 6 6 6 2 Parkin co-regulated protein Cohesin_HEAT PF12765.2 KOO22979.1 - 9.7e-05 22.2 1.5 3.4 7.7 0.1 4.8 4 0 0 4 4 4 2 HEAT repeat associated with sister chromatid cohesion Dopey_N PF04118.9 KOO22979.1 - 0.27 9.9 0.0 8.4 5.0 0.0 2.9 2 1 1 3 3 3 0 Dopey, N-terminal DUF4557 PF15101.1 KOO22979.1 - 0.38 10.5 0.9 2.5 7.8 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) PapD-like PF14874.1 KOO22980.1 - 5.8e-08 32.6 0.2 0.00037 20.3 0.0 5.4 6 0 0 6 6 6 1 Flagellar-associated PapD-like Motile_Sperm PF00635.21 KOO22980.1 - 0.00011 21.8 0.1 5.6 6.6 0.0 6.5 8 0 0 8 8 8 1 MSP (Major sperm protein) domain DUF1034 PF06280.7 KOO22980.1 - 0.22 11.9 0.0 1.2e+02 3.1 0.0 5.0 6 0 0 6 6 6 0 Fn3-like domain (DUF1034) Agenet PF05641.7 KOO22981.1 - 1.1e-15 57.5 9.8 9.7e-14 51.2 0.6 3.1 3 0 0 3 3 3 2 Agenet domain Chromo PF00385.19 KOO22981.1 - 1.6e-06 27.6 1.5 2.2e-06 27.2 0.0 2.1 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Lzipper-MIP1 PF14389.1 KOO22981.1 - 0.044 13.8 0.8 0.1 12.6 0.1 2.0 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Dynamin_N PF00350.18 KOO22982.1 - 6e-21 74.9 0.0 1.1e-20 74.0 0.0 1.5 1 0 0 1 1 1 1 Dynamin family U-box PF04564.10 KOO22982.1 - 4.4e-13 48.9 0.0 1.3e-12 47.5 0.0 1.8 1 0 0 1 1 1 1 U-box domain Dynamin_M PF01031.15 KOO22982.1 - 6e-07 28.5 0.0 3.5e-05 22.7 0.0 2.3 2 0 0 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.18 KOO22982.1 - 2.2e-05 24.3 0.0 0.00017 21.4 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase zf-Nse PF11789.3 KOO22982.1 - 5.3e-05 22.6 0.0 0.00012 21.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Miro PF08477.8 KOO22982.1 - 0.00031 21.2 0.0 0.0025 18.2 0.0 2.3 2 0 0 2 2 2 1 Miro-like protein zf-RING_UBOX PF13445.1 KOO22982.1 - 0.00068 19.2 0.0 0.0016 18.1 0.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger FdsD PF11390.3 KOO22982.1 - 0.016 15.2 0.0 0.048 13.7 0.0 1.8 1 0 0 1 1 1 0 NADH-dependant formate dehydrogenase delta subunit FdsD CO_deh_flav_C PF03450.12 KOO22982.1 - 0.034 14.0 0.5 0.11 12.3 0.4 1.9 1 0 0 1 1 1 0 CO dehydrogenase flavoprotein C-terminal domain Phage_lysozyme PF00959.14 KOO22983.1 - 0.081 13.2 0.0 0.22 11.8 0.0 1.5 1 1 1 2 2 2 0 Phage lysozyme UvrD_C PF13361.1 KOO22984.1 - 4.2e-11 42.9 0.0 1.2e-09 38.1 0.0 2.2 1 1 1 2 2 2 1 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.1 KOO22984.1 - 1.1e-09 38.2 0.1 0.00053 20.0 0.0 2.5 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.16 KOO22984.1 - 0.00031 20.1 0.0 0.00053 19.3 0.0 1.3 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain Dermcidin PF15291.1 KOO22984.1 - 0.0086 16.2 0.9 0.023 14.8 0.7 1.7 1 0 0 1 1 1 1 Dermcidin, antibiotic peptide Viral_helicase1 PF01443.13 KOO22984.1 - 0.13 11.7 0.2 13 5.1 0.0 2.8 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase DUF3639 PF12341.3 KOO22986.1 - 0.016 15.2 0.1 0.016 15.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3639) SdiA-regulated PF06977.6 KOO22986.1 - 0.047 12.6 0.0 0.4 9.5 0.0 2.4 2 0 0 2 2 2 0 SdiA-regulated WD40 PF00400.27 KOO22986.1 - 0.067 13.1 8.7 36 4.4 0.1 6.4 7 0 0 7 7 7 0 WD domain, G-beta repeat SRP14 PF02290.10 KOO22987.1 - 8e-19 67.3 0.1 1.6e-18 66.3 0.0 1.6 2 0 0 2 2 2 1 Signal recognition particle 14kD protein Ank_2 PF12796.2 KOO22988.1 - 3.4e-23 81.7 0.0 1.3e-16 60.7 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO22988.1 - 7.1e-16 57.1 0.1 1.1e-06 28.1 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 KOO22988.1 - 1.3e-12 47.5 0.7 3.5e-08 33.4 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO22988.1 - 1.2e-11 44.7 0.4 5.1e-06 26.8 0.0 3.3 1 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO22988.1 - 2.8e-11 42.5 0.0 0.00073 19.5 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat ADH_N PF08240.7 KOO22989.1 - 1.1e-21 76.6 1.9 1.6e-21 76.1 1.3 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 KOO22989.1 - 7.2e-17 61.1 0.0 1.3e-16 60.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 KOO22989.1 - 4.2e-06 27.6 0.0 9e-06 26.5 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 KOO22989.1 - 0.0059 15.7 0.0 0.0098 15.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Glyco_transf_28 PF03033.15 KOO22990.1 - 0.02 14.6 6.7 2 8.1 0.1 3.2 3 0 0 3 3 3 0 Glycosyltransferase family 28 N-terminal domain PEP-utilisers_N PF05524.8 KOO22990.1 - 0.67 9.7 5.3 2.2 8.1 0.0 2.9 3 0 0 3 3 3 0 PEP-utilising enzyme, N-terminal YrhK PF14145.1 KOO22991.1 - 2.2e-08 33.6 28.2 0.0014 18.2 3.9 3.8 3 1 0 3 3 3 3 YrhK-like protein EF-hand_5 PF13202.1 KOO22992.1 - 1.5e-15 55.7 5.5 5e-07 28.7 0.1 2.2 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.27 KOO22992.1 - 2.5e-15 54.5 2.2 4.1e-07 28.8 0.8 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO22992.1 - 7.3e-13 47.2 1.3 1.6e-06 27.4 0.2 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO22992.1 - 2.2e-11 43.7 1.7 2.9e-05 24.1 0.3 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO22992.1 - 7e-11 41.5 1.3 0.00011 21.7 0.4 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.2 KOO22992.1 - 3.5e-06 26.6 0.1 7.5e-05 22.4 0.0 2.1 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO22992.1 - 0.0017 18.3 0.2 0.12 12.4 0.1 2.2 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region VCBS PF13517.1 KOO22992.1 - 0.076 13.3 1.6 1.4 9.3 0.0 2.2 2 0 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella EF-hand_10 PF14788.1 KOO22992.1 - 0.1 12.2 0.2 1.6 8.4 0.1 2.1 2 0 0 2 2 2 0 EF hand Excalibur PF05901.6 KOO22992.1 - 8.6 6.8 6.4 35 4.8 0.1 2.9 2 1 0 2 2 2 0 Excalibur calcium-binding domain Drf_FH3 PF06367.11 KOO22993.1 - 0.036 13.4 0.0 0.055 12.8 0.0 1.2 1 0 0 1 1 1 0 Diaphanous FH3 Domain Tic22 PF04278.7 KOO22994.1 - 2.4e-21 76.2 0.0 3.2e-21 75.8 0.0 1.1 1 0 0 1 1 1 1 Tic22-like family Phe_tRNA-synt_N PF02912.13 KOO22995.1 - 0.0089 15.7 0.3 0.024 14.3 0.1 1.9 2 0 0 2 2 2 1 Aminoacyl tRNA synthetase class II, N-terminal domain PALP PF00291.20 KOO22997.1 - 1.3e-72 244.5 2.0 1.7e-72 244.2 1.4 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ACT PF01842.20 KOO22997.1 - 0.00041 19.7 0.7 0.0034 16.8 0.0 2.7 3 0 0 3 3 3 1 ACT domain ACT_4 PF13291.1 KOO22997.1 - 0.0069 16.7 0.0 0.017 15.4 0.0 1.6 1 0 0 1 1 1 1 ACT domain TPMT PF05724.6 KOO22997.1 - 0.094 12.1 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) E2F_TDP PF02319.15 KOO22998.1 - 1.4e-19 69.4 0.0 2.7e-19 68.5 0.0 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain DP PF08781.5 KOO22998.1 - 1.8e-06 27.6 0.0 3.5e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Transcription factor DP GPP34 PF05719.6 KOO22998.1 - 0.047 13.7 1.1 0.086 12.8 0.6 1.4 1 1 0 1 1 1 0 Golgi phosphoprotein 3 (GPP34) PHD PF00628.24 KOO22999.1 - 8.9e-05 22.1 4.1 8.9e-05 22.1 2.9 3.0 2 1 1 3 3 3 1 PHD-finger zf-C2H2_jaz PF12171.3 KOO22999.1 - 1.6 8.9 5.2 12 6.1 0.1 2.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding DUF605 PF04652.11 KOO22999.1 - 3.7 6.8 17.0 4.6 6.5 11.8 1.1 1 0 0 1 1 1 0 Vta1 like C1_1 PF00130.17 KOO22999.1 - 5.7 6.7 11.2 0.45 10.2 0.8 2.7 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF2489 PF10675.4 KOO23000.1 - 0.0013 18.4 2.9 0.0013 18.4 2.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF2489) Pex14_N PF04695.8 KOO23000.1 - 1.5 8.9 5.4 0.41 10.6 0.2 2.4 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region LRR_6 PF13516.1 KOO23001.1 - 1.4e-19 67.9 9.7 0.00045 19.9 0.0 8.9 10 0 0 10 10 10 5 Leucine Rich repeat LRR_1 PF00560.28 KOO23001.1 - 6.9e-08 31.4 1.6 5.9 7.3 0.0 6.7 8 0 0 8 8 8 2 Leucine Rich Repeat LRR_4 PF12799.2 KOO23001.1 - 4.6e-07 29.3 3.2 0.012 15.2 0.0 5.3 6 1 2 8 8 8 3 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO23001.1 - 4.8e-06 25.9 9.0 2.7 8.5 0.0 7.9 9 0 0 9 9 9 1 Leucine rich repeat LRR_8 PF13855.1 KOO23001.1 - 5.7e-05 22.7 3.0 1 9.1 0.0 5.3 4 1 1 5 5 5 3 Leucine rich repeat Exostosin PF03016.10 KOO23002.1 - 7.2e-22 77.8 0.0 9.8e-22 77.3 0.0 1.2 1 0 0 1 1 1 1 Exostosin family LRR_8 PF13855.1 KOO23003.1 - 9.2e-09 34.9 2.8 0.15 11.8 0.0 4.7 3 2 2 5 5 5 4 Leucine rich repeat LRR_4 PF12799.2 KOO23003.1 - 8.5e-07 28.4 0.2 0.22 11.2 0.0 5.2 5 1 1 6 6 6 2 Leucine Rich repeats (2 copies) Aldo_ket_red PF00248.16 KOO23004.1 - 2.7e-34 118.3 0.0 4.2e-34 117.6 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family BCLP PF12304.3 KOO23004.1 - 0.027 13.9 0.2 0.042 13.2 0.1 1.3 1 0 0 1 1 1 0 Beta-casein like protein Dynein_heavy PF03028.10 KOO23005.1 - 2.6e-177 591.0 0.0 3.5e-131 438.5 0.0 2.3 2 0 0 2 2 2 2 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.8 KOO23005.1 - 4.1e-135 450.4 0.5 4.1e-135 450.4 0.4 2.1 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 KOO23005.1 - 9.8e-91 303.3 0.1 2e-90 302.3 0.1 1.5 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_9 PF12781.2 KOO23005.1 - 1.5e-58 197.3 0.4 3.2e-58 196.2 0.3 1.6 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 MT PF12777.2 KOO23005.1 - 1.5e-53 181.8 9.1 4.1e-53 180.3 6.3 1.8 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_8 PF12780.2 KOO23005.1 - 1.6e-52 178.1 0.1 3.7e-47 160.5 0.0 2.4 1 1 1 2 2 2 2 P-loop containing dynein motor region D4 AAA_7 PF12775.2 KOO23005.1 - 8.5e-51 172.6 0.0 2e-50 171.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_5 PF07728.9 KOO23005.1 - 3.7e-10 39.6 0.0 0.014 15.1 0.0 5.7 4 2 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA PF00004.24 KOO23005.1 - 0.00013 22.1 0.1 1.1 9.4 0.0 3.9 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 KOO23005.1 - 0.0007 20.4 0.0 0.026 15.3 0.0 3.6 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.1 KOO23005.1 - 0.0011 18.6 2.7 0.74 9.6 0.0 3.2 3 0 0 3 3 2 2 Part of AAA domain AAA_22 PF13401.1 KOO23005.1 - 0.0012 18.9 0.0 6.2 6.9 0.0 4.4 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.1 KOO23005.1 - 0.0014 18.6 0.4 3.8 7.4 0.1 3.9 2 1 1 3 3 3 1 AAA ATPase domain RNA_helicase PF00910.17 KOO23005.1 - 0.0082 16.3 0.1 3.6 7.8 0.0 3.6 3 0 0 3 3 3 1 RNA helicase AAA_18 PF13238.1 KOO23005.1 - 0.047 13.9 0.0 0.72 10.1 0.0 2.9 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.21 KOO23005.1 - 0.052 13.0 0.1 1.4 8.3 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_33 PF13671.1 KOO23005.1 - 0.066 13.0 0.0 16 5.3 0.0 3.4 3 0 0 3 3 3 0 AAA domain UPF0079 PF02367.12 KOO23005.1 - 0.087 12.4 0.8 30 4.2 0.0 3.2 3 0 0 3 3 3 0 Uncharacterised P-loop hydrolase UPF0079 TPR_MLP1_2 PF07926.7 KOO23005.1 - 6.9 6.4 25.6 0.19 11.4 1.4 4.4 4 1 0 4 4 3 0 TPR/MLP1/MLP2-like protein Pkinase PF00069.20 KOO23006.1 - 2.4e-34 118.6 0.0 2e-33 115.6 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO23006.1 - 1.1e-10 41.0 0.0 9.7e-07 28.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.9 KOO23006.1 - 0.087 11.8 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_7 PF13499.1 KOO23007.1 - 1.2e-08 34.9 0.1 2.8e-06 27.3 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO23007.1 - 7.2e-08 31.6 0.1 0.0093 15.7 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.1 KOO23007.1 - 2e-06 27.3 0.0 0.012 15.1 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO23007.1 - 5.3e-06 25.3 0.6 0.028 13.6 0.0 3.4 3 0 0 3 3 3 2 EF hand DUF490 PF04357.8 KOO23007.1 - 0.021 13.9 0.0 0.03 13.4 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF490) EF-hand_7 PF13499.1 KOO23008.1 - 2.3e-24 85.3 0.1 4.7e-11 42.6 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO23008.1 - 5.8e-19 65.8 4.5 0.0015 17.6 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO23008.1 - 2.4e-16 59.0 0.4 3.8e-07 29.6 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO23008.1 - 4.1e-16 57.4 3.8 0.0049 16.1 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO23008.1 - 1e-15 56.0 3.0 0.0025 17.5 0.0 4.8 4 0 0 4 4 4 4 EF-hand domain Ion_trans PF00520.26 KOO23008.1 - 1.5e-09 37.3 5.6 2.6e-09 36.6 3.9 1.3 1 0 0 1 1 1 1 Ion transport protein EF-hand_9 PF14658.1 KOO23008.1 - 5.5e-08 32.6 0.0 0.011 15.6 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain cNMP_binding PF00027.24 KOO23008.1 - 5.4e-05 22.9 0.0 0.00012 21.7 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain EF-hand_4 PF12763.2 KOO23008.1 - 0.0081 15.8 0.5 1.2 8.9 0.0 2.6 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO23008.1 - 0.01 15.8 0.0 6.4 6.8 0.0 2.4 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF4473 PF14747.1 KOO23008.1 - 0.031 14.4 0.7 9.3 6.5 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4473) DUF3349 PF11829.3 KOO23008.1 - 0.16 12.4 0.0 20 5.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3349) Gar1 PF04410.9 KOO23009.1 - 5.3e-24 84.4 0.0 3.5e-20 72.0 0.0 2.4 2 0 0 2 2 2 2 Gar1/Naf1 RNA binding region Thioredoxin PF00085.15 KOO23010.1 - 4.9e-35 119.3 0.0 3.2e-16 58.9 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_7 PF13899.1 KOO23010.1 - 2.5e-07 30.6 0.0 0.0041 17.1 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.1 KOO23010.1 - 2.9e-05 24.0 0.0 0.37 10.9 0.0 3.3 2 1 1 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.16 KOO23010.1 - 0.00016 21.3 0.0 0.022 14.4 0.0 2.3 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_2 PF13098.1 KOO23010.1 - 0.00024 21.2 0.0 0.16 12.2 0.0 3.0 2 2 0 2 2 2 2 Thioredoxin-like domain Glyco_transf_29 PF00777.13 KOO23011.1 - 0.00053 19.2 0.0 0.00061 19.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) zf-SNAP50_C PF12251.3 KOO23012.1 - 1.5e-23 83.2 0.8 1.8e-23 82.9 0.6 1.1 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal MtN3_slv PF03083.11 KOO23013.1 - 1.2e-32 111.6 0.7 3.8e-18 65.1 0.1 2.1 2 0 0 2 2 2 2 Sugar efflux transporter for intercellular exchange DUF1939 PF09154.5 KOO23014.1 - 0.037 13.9 0.4 11 6.0 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1939) Orai-1 PF07856.7 KOO23015.1 - 0.0011 18.5 2.3 0.0098 15.4 0.1 2.1 2 0 0 2 2 2 2 Mediator of CRAC channel activity DEAD PF00270.24 KOO23018.1 - 5.8e-36 123.5 0.1 2.2e-34 118.3 0.0 2.5 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO23018.1 - 4.7e-26 90.4 0.0 9.2e-26 89.5 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SecA_DEAD PF07517.9 KOO23018.1 - 0.0087 15.3 0.0 0.017 14.3 0.0 1.4 1 0 0 1 1 1 1 SecA DEAD-like domain DUF1253 PF06862.7 KOO23018.1 - 0.042 12.2 0.1 0.23 9.8 0.0 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1253) Helicase_C_2 PF13307.1 KOO23018.1 - 0.047 13.6 0.0 0.093 12.6 0.0 1.5 1 0 0 1 1 1 0 Helicase C-terminal domain ResIII PF04851.10 KOO23018.1 - 0.089 12.6 0.0 0.49 10.2 0.0 2.2 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit zf-CCHC PF00098.18 KOO23018.1 - 2.2 8.3 8.4 0.22 11.5 1.6 2.3 2 0 0 2 2 2 0 Zinc knuckle HEAT_2 PF13646.1 KOO23019.1 - 2e-05 24.8 7.4 3.3e-05 24.1 1.5 3.5 3 0 0 3 3 3 1 HEAT repeats HEAT_PBS PF03130.11 KOO23019.1 - 4.6 8.0 19.6 1 9.9 0.0 5.0 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat GTP_EFTU PF00009.22 KOO23020.1 - 3.4e-07 29.8 0.0 5e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 KOO23020.1 - 0.0023 17.7 0.0 0.0049 16.7 0.0 1.5 1 0 0 1 1 1 1 Translation-initiation factor 2 Viral_Rep PF02407.11 KOO23021.1 - 0.00026 20.9 0.0 0.0004 20.3 0.0 1.4 1 0 0 1 1 1 1 Putative viral replication protein DSPc PF00782.15 KOO23022.1 - 1.6e-16 60.0 0.0 2.1e-16 59.7 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KOO23022.1 - 0.00054 19.3 0.0 0.00072 18.9 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 KOO23022.1 - 0.02 15.1 0.1 0.033 14.4 0.1 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF3486 PF11985.3 KOO23022.1 - 0.021 14.8 0.0 0.03 14.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3486) DUF969 PF06149.7 KOO23023.1 - 0.018 14.3 1.2 0.034 13.3 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF969) DEC-1_N PF04625.8 KOO23023.1 - 0.28 9.8 10.6 0.52 8.9 7.3 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region HAD_2 PF13419.1 KOO23024.1 - 4e-17 63.0 0.0 5.2e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOO23024.1 - 3.8e-11 42.5 0.0 7.6e-11 41.5 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 KOO23024.1 - 4.2e-11 43.6 0.5 1.1e-08 35.8 0.2 2.1 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO23024.1 - 1.5e-05 25.2 0.0 2e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Pkinase PF00069.20 KOO23026.1 - 1.6e-32 112.7 0.0 1.9e-30 105.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO23026.1 - 2.2e-19 69.5 0.0 1.2e-18 67.1 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Abhydrolase_6 PF12697.2 KOO23027.1 - 6.7e-06 26.1 1.6 8.3e-06 25.8 1.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.13 KOO23027.1 - 0.052 12.8 0.3 0.21 10.8 0.0 2.0 2 0 0 2 2 2 0 Dienelactone hydrolase family ASXH PF13919.1 KOO23028.1 - 0.0082 15.9 0.1 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 Asx homology domain Aminotran_3 PF00202.16 KOO23030.1 - 2e-68 230.7 0.1 4.1e-68 229.7 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class-III Aminotran_1_2 PF00155.16 KOO23030.1 - 0.0011 18.0 0.0 0.0015 17.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II SNF2_N PF00176.18 KOO23031.1 - 1e-16 60.6 0.0 1.4e-16 60.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOO23031.1 - 3.4e-08 33.2 0.0 6.3e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOO23031.1 - 0.0011 18.4 0.0 0.0026 17.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase PqqA PF08042.6 KOO23031.1 - 0.15 11.7 0.2 0.48 10.1 0.2 1.9 1 0 0 1 1 1 0 PqqA family TTL PF03133.10 KOO23032.1 - 1.3e-94 316.3 0.0 1.9e-94 315.9 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 KOO23032.1 - 1.2e-05 24.2 0.2 0.0023 16.7 0.0 2.7 2 1 0 2 2 2 2 YheC/D like ATP-grasp ATP-grasp_4 PF13535.1 KOO23032.1 - 0.054 13.2 0.0 0.12 12.1 0.0 1.6 1 1 0 1 1 1 0 ATP-grasp domain EnY2 PF10163.4 KOO23033.1 - 2.4e-28 97.8 0.5 2.7e-28 97.7 0.4 1.0 1 0 0 1 1 1 1 Transcription factor e(y)2 Chromo PF00385.19 KOO23034.1 - 9.6e-06 25.1 0.1 1.7e-05 24.4 0.1 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain 2OG-FeII_Oxy_3 PF13640.1 KOO23035.1 - 3.5e-05 24.2 0.0 6.5e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Methyltransf_18 PF12847.2 KOO23035.1 - 3.6e-05 24.3 0.1 7e-05 23.3 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO23035.1 - 0.0019 18.4 0.2 0.0042 17.4 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO23035.1 - 0.0032 17.9 0.2 0.0088 16.5 0.1 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO23035.1 - 0.0051 17.2 0.0 0.0089 16.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO23035.1 - 0.011 15.7 0.8 0.011 15.7 0.5 2.1 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.1 KOO23035.1 - 0.019 14.5 0.7 0.028 13.9 0.5 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 KOO23035.1 - 0.043 13.5 0.0 0.074 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.7 KOO23035.1 - 0.086 12.2 0.3 0.15 11.4 0.2 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Retinal PF15449.1 KOO23035.1 - 5.8 4.4 9.4 3.5 5.1 0.1 2.0 2 0 0 2 2 2 0 Retinal protein WD40 PF00400.27 KOO23036.1 - 8.9e-90 291.6 33.0 9.6e-13 47.4 0.3 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat Chloroa_b-bind PF00504.16 KOO23036.1 - 2.8e-28 99.1 0.0 5.4e-28 98.2 0.0 1.5 1 0 0 1 1 1 1 Chlorophyll A-B binding protein PD40 PF07676.7 KOO23036.1 - 6.7e-14 51.1 6.6 2 8.1 0.0 7.5 7 0 0 7 7 7 6 WD40-like Beta Propeller Repeat Dfp1_Him1_M PF08630.5 KOO23036.1 - 1.7e-06 27.8 5.1 4.7 7.0 0.0 5.5 5 0 0 5 5 5 3 Dfp1/Him1, central region DUF3312 PF11768.3 KOO23036.1 - 1.5e-05 23.4 0.0 5.4 5.1 0.0 4.4 1 1 5 6 6 6 5 Protein of unknown function (DUF3312) PAN_1 PF00024.21 KOO23037.1 - 3.2e-05 23.5 0.3 6.9e-05 22.5 0.2 1.5 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.1 KOO23037.1 - 8.9e-05 22.1 0.4 0.00022 20.8 0.3 1.7 1 0 0 1 1 1 1 PAN domain fn3 PF00041.16 KOO23037.1 - 0.0023 18.0 0.0 2.2 8.4 0.0 2.6 2 0 0 2 2 2 2 Fibronectin type III domain DUF897 PF05982.7 KOO23038.1 - 0.07 11.9 0.1 0.08 11.7 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF897) DUF726 PF05277.7 KOO23039.1 - 1.8e-69 234.2 23.8 2.2e-60 204.3 0.0 3.6 3 1 0 3 3 3 2 Protein of unknown function (DUF726) UBA PF00627.26 KOO23039.1 - 0.0053 16.5 0.4 0.05 13.4 0.0 2.9 3 0 0 3 3 3 1 UBA/TS-N domain Ion_trans PF00520.26 KOO23040.1 - 0.00049 19.4 1.7 0.00049 19.4 1.2 1.9 3 0 0 3 3 3 1 Ion transport protein TrkH PF02386.11 KOO23040.1 - 0.034 12.7 0.2 0.034 12.7 0.1 2.4 3 0 0 3 3 3 0 Cation transport protein Ank_2 PF12796.2 KOO23042.1 - 4e-36 123.2 6.3 1.7e-14 53.8 0.0 4.1 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO23042.1 - 1.9e-35 118.8 12.0 3.3e-08 32.9 0.0 7.2 6 1 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.1 KOO23042.1 - 2.3e-26 91.6 6.3 4.4e-08 33.4 0.0 5.8 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO23042.1 - 2.1e-22 78.5 12.9 1.6e-07 31.3 0.1 5.0 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO23042.1 - 1.4e-21 74.4 3.1 0.00014 21.7 0.0 6.0 6 0 0 6 6 6 5 Ankyrin repeat DUF4486 PF14858.1 KOO23043.1 - 4.7e-29 101.0 0.0 6.8e-27 93.9 0.0 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4486) Cellulase PF00150.13 KOO23044.1 - 2.4e-11 43.3 2.0 6.2e-11 42.0 1.4 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF4231 PF14015.1 KOO23045.1 - 5.9e-05 23.0 0.4 0.00022 21.1 0.3 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF4231) Mre11_DNA_bind PF04152.9 KOO23046.1 - 6.5e-39 133.5 0.0 1.6e-38 132.2 0.0 1.7 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.23 KOO23046.1 - 5.6e-19 68.3 0.1 8.2e-19 67.7 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KOO23046.1 - 0.00027 20.8 0.0 0.0024 17.7 0.0 2.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Macro PF01661.16 KOO23047.1 - 6.4e-22 77.6 0.0 1.2e-21 76.8 0.0 1.4 1 0 0 1 1 1 1 Macro domain YtzH PF14165.1 KOO23047.1 - 0.05 13.8 0.1 0.082 13.1 0.1 1.3 1 0 0 1 1 1 0 YtzH-like protein LRR_6 PF13516.1 KOO23048.1 - 1.4e-05 24.6 0.1 0.083 13.0 0.0 3.8 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.28 KOO23048.1 - 0.11 12.5 0.3 22 5.5 0.0 3.5 2 1 0 2 2 2 0 Leucine Rich Repeat COPI_C PF06957.6 KOO23048.1 - 6 5.2 8.2 8.4 4.7 5.7 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus Nbl1_Borealin_N PF10444.4 KOO23050.1 - 1.1e-07 31.1 0.4 1.1e-07 31.1 0.3 1.6 2 0 0 2 2 2 1 Nbl1 / Borealin N terminal NLE PF08154.7 KOO23050.1 - 0.0058 16.6 0.2 0.19 11.7 0.1 2.2 2 0 0 2 2 2 1 NLE (NUC135) domain DC_STAMP PF07782.8 KOO23050.1 - 0.18 11.4 0.0 0.27 10.8 0.0 1.2 1 0 0 1 1 1 0 DC-STAMP-like protein PKD_channel PF08016.7 KOO23051.1 - 1.2e-20 73.3 9.8 7.6e-19 67.4 7.9 2.1 2 0 0 2 2 2 1 Polycystin cation channel EF-hand_7 PF13499.1 KOO23051.1 - 2.9e-09 36.9 1.5 7.2e-09 35.6 1.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO23051.1 - 3.4e-08 32.7 0.5 0.0027 17.4 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO23051.1 - 3.5e-08 32.9 0.2 8.5e-08 31.6 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO23051.1 - 1.4e-07 30.2 0.9 0.00028 19.9 0.1 2.8 2 0 0 2 2 2 2 EF hand Ion_trans PF00520.26 KOO23051.1 - 3.1e-06 26.5 19.1 3.1e-06 26.5 13.2 1.8 2 0 0 2 2 2 1 Ion transport protein EF-hand_5 PF13202.1 KOO23051.1 - 5.3e-06 25.5 1.6 0.00012 21.2 0.1 2.9 2 0 0 2 2 2 1 EF hand MRP-S24 PF14955.1 KOO23051.1 - 0.22 11.3 0.0 0.47 10.2 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S24 PqiA PF04403.8 KOO23052.1 - 2.1e-13 50.1 22.8 3.6e-08 33.1 5.6 2.7 3 0 0 3 3 3 2 Paraquat-inducible protein A JHBP PF06585.6 KOO23053.1 - 0.035 12.9 0.0 0.067 11.9 0.0 1.4 1 0 0 1 1 1 0 Haemolymph juvenile hormone binding protein (JHBP) WW PF00397.21 KOO23055.1 - 0.021 14.6 0.2 0.049 13.5 0.1 1.6 1 0 0 1 1 1 0 WW domain Arm PF00514.18 KOO23056.1 - 1.3e-92 300.7 103.2 3.2e-09 36.2 0.2 31.3 32 2 0 32 32 32 21 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.4 KOO23056.1 - 2.1e-08 33.8 0.6 0.49 10.1 0.0 7.8 10 0 0 10 10 10 2 Spinocerebellar ataxia type 10 protein domain V-ATPase_H_N PF03224.9 KOO23056.1 - 6.8e-06 25.4 7.2 0.77 8.8 0.6 6.5 4 2 1 5 5 5 3 V-ATPase subunit H Arm_2 PF04826.8 KOO23056.1 - 5e-05 22.5 14.2 2.1 7.3 0.1 8.7 8 2 3 11 11 11 2 Armadillo-like HEAT_2 PF13646.1 KOO23056.1 - 0.00011 22.4 98.3 0.00022 21.4 1.5 13.6 7 3 7 14 14 14 4 HEAT repeats EF-hand_5 PF13202.1 KOO23056.1 - 0.0026 17.0 0.0 0.0071 15.6 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KOO23056.1 - 0.078 12.3 0.0 0.24 10.8 0.0 1.7 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.1 KOO23056.1 - 0.34 11.0 0.0 0.91 9.7 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair HEAT PF02985.17 KOO23056.1 - 2.1 8.6 35.6 2.7 8.2 0.0 10.6 12 0 0 12 12 12 0 HEAT repeat TauD PF02668.11 KOO23057.1 - 2.6e-18 66.6 0.0 3.9e-18 66.0 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.7 KOO23057.1 - 0.00011 22.5 0.0 0.0072 16.7 0.0 2.4 1 1 1 2 2 2 1 Protein of unknown function (DUF971) Arm PF00514.18 KOO23059.1 - 7.7e-49 161.9 32.9 2e-07 30.5 0.4 10.3 10 0 0 10 10 10 10 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO23059.1 - 1.9e-10 40.8 43.6 0.0011 19.1 3.1 5.8 2 2 3 6 6 6 5 HEAT repeats Atx10homo_assoc PF09759.4 KOO23059.1 - 3e-07 30.1 0.0 0.0015 18.1 0.0 4.3 4 1 1 5 5 5 1 Spinocerebellar ataxia type 10 protein domain V-ATPase_H_N PF03224.9 KOO23059.1 - 4.4e-06 26.0 0.0 0.2 10.7 0.0 3.1 1 1 1 2 2 2 2 V-ATPase subunit H Adaptin_N PF01602.15 KOO23059.1 - 4.5e-05 21.9 0.1 0.2 9.9 0.1 3.8 1 1 0 2 2 2 2 Adaptin N terminal region DUF3361 PF11841.3 KOO23059.1 - 0.0043 16.7 4.8 2.6 7.7 0.0 3.8 3 1 1 4 4 4 1 Domain of unknown function (DUF3361) RYDR_ITPR PF01365.16 KOO23059.1 - 0.027 13.7 0.1 0.074 12.2 0.1 1.8 1 1 0 1 1 1 0 RIH domain Peptidase_C25_C PF03785.9 KOO23059.1 - 0.033 13.9 0.2 14 5.5 0.0 2.7 2 0 0 2 2 2 0 Peptidase family C25, C terminal ig-like domain HEAT_EZ PF13513.1 KOO23059.1 - 1.3 9.6 45.4 2.4 8.7 3.5 7.6 4 3 4 8 8 8 0 HEAT-like repeat HEAT PF02985.17 KOO23059.1 - 8 6.8 24.8 4.4 7.6 0.0 8.4 10 0 0 10 10 10 0 HEAT repeat Arm PF00514.18 KOO23060.1 - 0.0036 17.0 0.2 2.6 8.0 0.0 2.9 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO23060.1 - 0.046 13.9 0.5 0.073 13.3 0.4 1.3 1 1 0 1 1 1 0 HEAT repeats Chromo PF00385.19 KOO23061.1 - 4.1e-13 48.7 1.3 1.6e-12 46.9 0.5 2.4 3 0 0 3 3 3 1 Chromo (CHRromatin Organisation MOdifier) domain Spectrin PF00435.16 KOO23061.1 - 0.034 14.4 6.0 0.084 13.1 3.9 1.9 1 1 0 1 1 1 0 Spectrin repeat Fe-S_assembly PF04384.8 KOO23061.1 - 0.073 13.4 0.4 0.21 11.9 0.3 1.7 1 0 0 1 1 1 0 Iron-sulphur cluster assembly FlgN PF05130.7 KOO23061.1 - 0.11 12.7 0.2 0.11 12.7 0.2 2.8 2 0 0 2 2 2 0 FlgN protein FERM_M PF00373.13 KOO23062.1 - 1.1e-07 32.0 0.4 3.9e-07 30.3 0.0 2.0 2 0 0 2 2 2 1 FERM central domain FERM_N PF09379.5 KOO23062.1 - 0.0044 17.0 0.0 0.011 15.8 0.0 1.7 1 0 0 1 1 1 1 FERM N-terminal domain DUF2443 PF10398.4 KOO23062.1 - 0.18 11.6 1.6 2.5 7.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2443) HALZ PF02183.13 KOO23062.1 - 7.8 6.3 10.1 0.15 11.8 0.5 2.9 2 1 1 3 3 3 0 Homeobox associated leucine zipper DUF972 PF06156.8 KOO23062.1 - 8.9 6.7 8.9 0.47 10.8 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Arm PF00514.18 KOO23065.1 - 7.2e-17 60.5 10.5 0.00014 21.5 0.0 6.7 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO23065.1 - 0.00073 19.7 19.5 0.11 12.7 3.1 3.6 2 2 1 3 3 3 2 HEAT repeats HEAT PF02985.17 KOO23065.1 - 0.00088 19.1 0.9 0.31 11.2 0.1 3.8 3 0 0 3 3 3 1 HEAT repeat Patatin PF01734.17 KOO23067.1 - 6.8e-18 65.3 0.6 1.5e-17 64.1 0.1 1.8 2 0 0 2 2 2 1 Patatin-like phospholipase DUF3336 PF11815.3 KOO23067.1 - 5.4e-12 45.4 0.0 8.8e-12 44.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Nucleotid_trans PF03407.11 KOO23068.1 - 7.9e-07 29.0 0.2 1.1e-06 28.5 0.1 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase LptE PF04390.7 KOO23069.1 - 0.0055 16.4 0.3 0.013 15.2 0.2 1.6 1 0 0 1 1 1 1 Lipopolysaccharide-assembly Pescadillo_N PF06732.6 KOO23069.1 - 0.063 12.5 0.0 0.096 11.9 0.0 1.2 1 0 0 1 1 1 0 Pescadillo N-terminus LRR_6 PF13516.1 KOO23070.1 - 1.1e-20 71.2 20.5 0.049 13.7 0.1 9.5 10 0 0 10 10 10 7 Leucine Rich repeat LRR_4 PF12799.2 KOO23070.1 - 4.9e-11 41.9 5.0 0.15 11.7 0.0 5.9 5 1 0 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO23070.1 - 1.3e-05 24.5 10.0 8.7 6.8 0.0 7.7 8 1 0 8 8 8 2 Leucine Rich Repeat LRR_8 PF13855.1 KOO23070.1 - 0.00016 21.3 15.5 0.47 10.2 0.0 6.5 5 3 0 5 5 5 2 Leucine rich repeat LRR_7 PF13504.1 KOO23070.1 - 0.05 13.7 17.5 60 4.5 0.0 7.9 10 0 0 10 10 10 0 Leucine rich repeat DNA_pol_B_thumb PF14791.1 KOO23071.1 - 3.1e-22 78.0 0.2 9.4e-22 76.4 0.0 1.9 2 0 0 2 2 2 1 DNA polymerase beta thumb DNA_pol_B_palm PF14792.1 KOO23071.1 - 2.3e-18 66.2 0.0 6.4e-18 64.8 0.0 1.8 1 1 0 1 1 1 1 DNA polymerase beta palm DNA_pol_lambd_f PF10391.4 KOO23071.1 - 2.1e-10 39.9 0.2 1.1e-09 37.6 0.0 2.3 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.1 KOO23071.1 - 2.7e-10 40.2 0.2 3.6e-08 33.4 0.0 2.7 1 1 1 2 2 2 1 Helix-hairpin-helix domain HHH_5 PF14520.1 KOO23071.1 - 0.019 15.1 0.1 8 6.7 0.0 2.5 2 0 0 2 2 2 0 Helix-hairpin-helix domain RNA_pol_A_CTD PF03118.10 KOO23071.1 - 0.047 13.1 0.0 0.1 12.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain Ribosomal_L4 PF00573.17 KOO23072.1 - 1.2e-47 161.8 1.6 1.4e-47 161.5 1.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Methyltransf_26 PF13659.1 KOO23073.1 - 8.6e-15 54.8 2.7 8.6e-15 54.8 1.9 1.7 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 KOO23073.1 - 1.8e-14 53.4 0.1 3.9e-14 52.3 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 KOO23073.1 - 5.2e-10 38.9 0.1 8.6e-10 38.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.10 KOO23073.1 - 2e-08 33.8 0.0 3.3e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_23 PF13489.1 KOO23073.1 - 2e-06 27.6 0.1 0.0022 17.7 0.0 2.8 2 1 0 3 3 3 2 Methyltransferase domain Methyltransf_18 PF12847.2 KOO23073.1 - 5.2e-06 27.0 0.1 1e-05 26.0 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 KOO23073.1 - 6e-06 25.9 0.0 9.2e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_31 PF13847.1 KOO23073.1 - 1.9e-05 24.3 0.0 2.4e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TRM PF02005.11 KOO23073.1 - 0.00081 18.4 0.0 0.0012 17.9 0.0 1.2 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_11 PF08241.7 KOO23073.1 - 0.0051 17.2 0.0 0.012 16.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO23073.1 - 0.0062 16.8 0.0 0.012 15.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 KOO23073.1 - 0.02 14.3 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase DUF4267 PF14087.1 KOO23073.1 - 0.057 13.0 4.1 0.41 10.2 0.2 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4267) ADH_zinc_N PF00107.21 KOO23073.1 - 2.1 7.8 5.9 2.5 7.6 1.7 2.6 2 1 0 2 2 2 0 Zinc-binding dehydrogenase Ion_trans PF00520.26 KOO23074.1 - 2.2e-10 40.1 3.2 2.2e-10 40.1 2.2 2.4 2 0 0 2 2 2 2 Ion transport protein Ion_trans_2 PF07885.11 KOO23074.1 - 3e-07 30.0 5.8 7.8e-07 28.7 4.0 1.7 1 0 0 1 1 1 1 Ion channel Ion_trans_N PF08412.5 KOO23074.1 - 0.089 12.1 0.0 0.24 10.7 0.0 1.7 1 0 0 1 1 1 0 Ion transport protein N-terminal Reticulon PF02453.12 KOO23075.1 - 2.1e-08 33.9 0.7 2.1e-08 33.9 0.5 2.1 2 0 0 2 2 2 1 Reticulon AIP3 PF03915.8 KOO23076.1 - 0.0034 16.3 1.0 0.13 11.1 0.2 2.1 2 0 0 2 2 2 2 Actin interacting protein 3 Cep57_MT_bd PF06657.8 KOO23076.1 - 0.11 12.4 3.9 0.15 12.0 0.0 2.8 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 ERM PF00769.14 KOO23076.1 - 4.3 6.7 22.3 0.19 11.2 8.2 2.3 2 0 0 2 2 2 0 Ezrin/radixin/moesin family IFT20 PF14931.1 KOO23076.1 - 9.1 6.2 10.2 0.71 9.7 1.4 3.0 3 1 0 3 3 3 0 Intraflagellar transport complex B, subunit 20 DUF3321 PF11968.3 KOO23077.1 - 1.5e-28 99.9 0.0 2e-28 99.5 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase (DUF3321) Methyltransf_23 PF13489.1 KOO23077.1 - 2.2e-05 24.2 0.0 3.3e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO23077.1 - 0.032 14.7 0.0 0.071 13.5 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain HGTP_anticodon PF03129.15 KOO23078.1 - 5.9e-12 45.3 0.0 1.1e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain Siva PF05458.7 KOO23078.1 - 0.067 12.7 0.4 0.29 10.6 0.2 2.1 2 0 0 2 2 2 0 Cd27 binding protein (Siva) Protamine_P2 PF00841.14 KOO23078.1 - 0.73 10.4 6.4 1.5 9.3 4.4 1.5 1 0 0 1 1 1 0 Sperm histone P2 Atx10homo_assoc PF09759.4 KOO23079.1 - 0.0026 17.4 0.0 1.4 8.7 0.0 2.6 2 0 0 2 2 2 2 Spinocerebellar ataxia type 10 protein domain SR-25 PF10500.4 KOO23079.1 - 0.0028 17.1 7.1 0.0037 16.7 4.9 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Arm PF00514.18 KOO23079.1 - 0.011 15.5 0.1 1.9 8.4 0.0 3.5 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat DDHD PF02862.12 KOO23079.1 - 0.42 10.3 3.3 0.51 10.0 2.3 1.2 1 0 0 1 1 1 0 DDHD domain Pkinase PF00069.20 KOO23080.1 - 1.3e-37 129.3 0.0 2e-37 128.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO23080.1 - 9.8e-31 106.7 0.0 1.5e-30 106.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pro_isomerase PF00160.16 KOO23080.1 - 1.5e-19 70.7 0.0 2.6e-19 69.9 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD APH PF01636.18 KOO23080.1 - 0.00028 20.7 0.2 0.0076 16.0 0.1 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Dpy-30 PF05186.8 KOO23081.1 - 0.00013 21.4 0.0 0.00026 20.4 0.0 1.6 1 0 0 1 1 1 1 Dpy-30 motif Ebp2 PF05890.7 KOO23084.1 - 3.4e-57 193.8 3.3 3.9e-57 193.6 2.3 1.0 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 Tom37_C PF11801.3 KOO23084.1 - 0.051 13.4 2.0 0.073 12.9 1.4 1.2 1 0 0 1 1 1 0 Tom37 C-terminal domain WD40 PF00400.27 KOO23085.1 - 2.5e-23 81.0 11.8 4e-08 32.8 0.0 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat CAF1C_H4-bd PF12265.3 KOO23085.1 - 1e-16 60.5 0.0 2e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex LRR_6 PF13516.1 KOO23085.1 - 6.7e-11 41.0 6.5 0.15 12.1 0.0 6.2 6 0 0 6 6 6 4 Leucine Rich repeat LRR_8 PF13855.1 KOO23085.1 - 2.3e-05 24.0 0.3 0.57 9.9 0.4 4.1 3 1 1 4 4 4 1 Leucine rich repeat LRR_4 PF12799.2 KOO23085.1 - 2.8e-05 23.6 0.2 0.26 10.9 0.1 4.3 4 0 0 4 4 4 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO23085.1 - 0.00049 19.7 1.4 18 5.8 0.0 5.2 5 0 0 5 5 5 1 Leucine Rich Repeat DNA_pol_E_B PF04042.11 KOO23086.1 - 2e-29 102.3 0.2 2.7e-29 101.9 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Pol_alpha_B_N PF08418.5 KOO23086.1 - 4.5e-07 29.6 0.0 1.2e-06 28.2 0.0 1.7 1 1 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DUF399 PF04187.8 KOO23087.1 - 4.3e-45 153.8 0.0 5.9e-45 153.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF399 LRV PF01816.12 KOO23087.1 - 0.3 11.3 0.1 0.3 11.3 0.1 2.6 2 0 0 2 2 2 0 Leucine rich repeat variant HlyIII PF03006.15 KOO23088.1 - 0.0023 17.3 6.5 0.0025 17.2 4.5 1.1 1 0 0 1 1 1 1 Haemolysin-III related YrhC PF14143.1 KOO23088.1 - 0.0023 17.8 0.1 0.0038 17.1 0.1 1.3 1 0 0 1 1 1 1 YrhC-like protein DUF3814 PF12769.2 KOO23088.1 - 0.05 13.7 1.1 0.073 13.2 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3814) Ceramidase PF05875.7 KOO23088.1 - 0.2 10.7 5.5 0.21 10.6 3.4 1.3 1 1 0 1 1 1 0 Ceramidase Voltage_CLC PF00654.15 KOO23091.1 - 4.5e-26 91.7 15.6 6.7e-26 91.1 10.8 1.2 1 0 0 1 1 1 1 Voltage gated chloride channel UBA PF00627.26 KOO23092.1 - 0.071 12.9 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 UBA/TS-N domain DUF393 PF04134.7 KOO23093.1 - 5.3e-16 59.7 0.1 1.1e-15 58.7 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF393 Colicin_V PF02674.11 KOO23094.1 - 0.01 15.7 0.0 0.01 15.7 0.0 2.4 1 1 0 2 2 2 1 Colicin V production protein Orthoreo_P10 PF07204.6 KOO23094.1 - 0.074 12.8 0.6 0.2 11.4 0.0 1.9 2 0 0 2 2 2 0 Orthoreovirus membrane fusion protein p10 UPF0220 PF05255.6 KOO23094.1 - 0.38 10.0 6.7 0.47 9.6 0.1 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0220) DUF4345 PF14248.1 KOO23094.1 - 1.3 8.5 8.6 2.2 7.7 3.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4345) DUF3464 PF11947.3 KOO23094.1 - 1.9 7.9 4.2 3.8 6.9 2.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) Claudin_2 PF13903.1 KOO23094.1 - 8.7 5.9 15.6 8.7 6.0 4.2 2.6 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction TCR PF03638.10 KOO23095.1 - 2.4e-23 81.6 55.0 3.4e-13 49.2 14.2 2.6 3 0 0 3 3 3 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain CDC37_N PF03234.9 KOO23096.1 - 0.17 12.1 3.1 0.23 11.7 2.1 1.2 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding Methyltransf_23 PF13489.1 KOO23097.1 - 2.6e-08 33.7 0.3 7.5e-08 32.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO23097.1 - 5.4e-08 33.2 0.1 1.8e-07 31.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO23097.1 - 3.9e-05 24.0 0.1 0.00013 22.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO23097.1 - 0.0045 16.5 0.0 0.0071 15.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO23097.1 - 0.03 13.4 0.0 0.056 12.5 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Glyco_tranf_2_3 PF13641.1 KOO23098.1 - 7.9e-23 81.4 0.0 1.1e-22 80.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 KOO23098.1 - 3.2e-20 72.6 2.0 5.2e-20 71.9 1.4 1.3 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.1 KOO23098.1 - 4.9e-10 38.9 0.0 8.4e-10 38.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 KOO23098.1 - 7.4e-07 29.0 0.0 1e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 AIG1 PF04548.11 KOO23099.1 - 2.4e-08 33.3 0.0 4.7e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 KOO23099.1 - 3.5e-07 30.1 0.0 9.7e-07 28.7 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 KOO23099.1 - 0.00042 20.1 1.4 0.71 9.6 0.0 2.7 2 1 1 3 3 3 2 Dynamin family IIGP PF05049.8 KOO23099.1 - 0.00075 18.4 0.0 0.0018 17.1 0.0 1.5 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) DUF258 PF03193.11 KOO23099.1 - 0.01 15.0 0.0 0.02 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 FtsK_SpoIIIE PF01580.13 KOO23099.1 - 0.014 14.8 2.7 0.92 8.9 0.0 3.2 3 0 0 3 3 3 0 FtsK/SpoIIIE family AAA_29 PF13555.1 KOO23099.1 - 0.056 12.9 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Septin PF00735.13 KOO23099.1 - 0.063 12.2 0.0 0.13 11.2 0.0 1.4 1 0 0 1 1 1 0 Septin Mei5 PF10376.4 KOO23099.1 - 0.097 12.1 4.7 0.19 11.2 3.3 1.4 1 0 0 1 1 1 0 Double-strand recombination repair protein Herpes_Helicase PF02689.9 KOO23099.1 - 0.11 10.1 0.0 0.23 9.1 0.0 1.4 1 0 0 1 1 1 0 Helicase OmpH PF03938.9 KOO23099.1 - 0.38 10.6 5.0 0.11 12.3 1.3 1.7 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Tup_N PF08581.5 KOO23099.1 - 0.41 10.8 6.1 0.13 12.4 1.9 1.9 2 0 0 2 2 2 0 Tup N-terminal AAA PF00004.24 KOO23100.1 - 5.2e-27 94.6 0.0 8e-27 94.0 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO23100.1 - 0.0062 16.5 0.4 0.017 15.1 0.1 1.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 KOO23100.1 - 0.13 12.3 0.0 0.36 10.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain MGDG_synth PF06925.6 KOO23102.1 - 2.2e-23 82.9 0.0 2.2e-22 79.7 0.0 2.0 1 1 0 1 1 1 1 Monogalactosyldiacylglycerol (MGDG) synthase Glyco_tran_28_C PF04101.11 KOO23102.1 - 7.8e-10 38.6 0.0 1.5e-09 37.7 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 KOO23102.1 - 4.9e-08 32.5 0.1 0.0045 16.2 0.0 2.5 2 1 0 2 2 2 2 Glycosyl transferase family 1 Glyco_trans_4_4 PF13579.1 KOO23102.1 - 0.0047 17.0 9.0 0.022 14.9 4.5 3.0 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain Fis1_TPR_C PF14853.1 KOO23103.1 - 5.6e-07 29.3 0.5 5.6e-07 29.3 0.3 1.8 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.23 KOO23103.1 - 1.4e-05 24.5 0.1 1.4e-05 24.5 0.1 2.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOO23103.1 - 1.7e-05 24.3 3.8 1.8e-05 24.2 1.2 2.0 1 1 1 2 2 2 1 TPR repeat TPR_2 PF07719.12 KOO23103.1 - 3.5e-05 23.3 3.5 6.8e-05 22.4 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO23103.1 - 0.003 18.0 6.0 0.0051 17.3 0.1 2.9 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO23103.1 - 0.04 13.7 0.6 0.27 11.0 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.1 KOO23103.1 - 0.26 11.9 4.7 0.2 12.4 1.4 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat Pkinase PF00069.20 KOO23104.1 - 2.3e-24 85.9 0.0 3.2e-17 62.5 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO23104.1 - 2.8e-07 29.8 0.0 6e-06 25.5 0.0 2.3 1 1 1 2 2 2 1 Protein tyrosine kinase Uso1_p115_C PF04871.8 KOO23104.1 - 0.47 10.3 13.5 2 8.3 0.2 3.2 3 0 0 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region FA_hydroxylase PF04116.8 KOO23105.1 - 2e-14 53.9 21.3 3e-14 53.3 12.7 2.4 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Beta_helix PF13229.1 KOO23106.1 - 1.1e-96 320.9 38.6 1.5e-18 67.0 2.4 9.1 1 1 7 8 8 8 8 Right handed beta helix region NosD PF05048.8 KOO23106.1 - 1.4e-72 243.6 7.2 6.6e-14 51.6 1.9 7.2 3 3 4 7 7 7 7 Periplasmic copper-binding protein (NosD) Glycolytic PF00274.14 KOO23108.1 - 2.3e-149 496.5 0.0 2.6e-149 496.3 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I EMP24_GP25L PF01105.19 KOO23109.1 - 0.62 9.7 8.2 14 5.2 0.2 3.7 3 0 0 3 3 3 0 emp24/gp25L/p24 family/GOLD DUF1992 PF09350.5 KOO23109.1 - 1.3 8.8 5.0 10 6.0 0.4 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1992) DUF3584 PF12128.3 KOO23110.1 - 0.011 13.1 12.2 0.015 12.7 8.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4242 PF14026.1 KOO23110.1 - 0.37 10.9 3.6 0.4 10.8 1.6 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4242) AAA_13 PF13166.1 KOO23110.1 - 0.42 9.0 6.4 0.52 8.6 4.5 1.0 1 0 0 1 1 1 0 AAA domain PolyA_pol PF01743.15 KOO23110.1 - 1.2 9.3 3.6 0.88 9.7 0.9 1.8 1 1 1 2 2 2 0 Poly A polymerase head domain TPR_MLP1_2 PF07926.7 KOO23110.1 - 2.6 7.8 20.1 2.8 7.7 11.8 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein F_bP_aldolase PF01116.15 KOO23111.1 - 8.6e-91 303.9 0.0 9.9e-91 303.7 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II NPBW PF15180.1 KOO23114.1 - 0.2 11.3 3.6 0.078 12.6 0.4 1.8 2 0 0 2 2 2 0 Neuropeptides B and W ASFV_J13L PF05568.6 KOO23115.1 - 0.057 12.9 0.3 0.061 12.8 0.2 1.1 1 0 0 1 1 1 0 African swine fever virus J13L protein Glyco_transf_8 PF01501.15 KOO23116.1 - 7.8e-11 41.7 0.0 5.3e-10 39.0 0.0 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 8 Sulfotransfer_3 PF13469.1 KOO23116.1 - 0.0082 17.0 1.7 0.19 12.6 0.0 3.0 2 1 0 2 2 2 1 Sulfotransferase family FKBP_C PF00254.23 KOO23117.1 - 2.3e-24 85.1 0.0 4.3e-24 84.3 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase SR-25 PF10500.4 KOO23117.1 - 0.012 15.1 21.5 0.017 14.5 14.9 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Herpes_DNAp_acc PF04929.7 KOO23117.1 - 0.2 10.5 6.3 0.23 10.4 4.3 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor DUF1635 PF07795.6 KOO23117.1 - 0.24 10.7 3.7 0.4 10.0 2.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Med19 PF10278.4 KOO23117.1 - 1.7 8.2 9.5 2.5 7.7 6.6 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 SpoIIIAH PF12685.2 KOO23117.1 - 5.6 6.4 9.4 7.5 5.9 6.5 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein Beta_helix PF13229.1 KOO23118.1 - 1e-38 132.6 0.0 8.4e-15 54.8 0.0 5.0 3 2 2 5 5 5 4 Right handed beta helix region NosD PF05048.8 KOO23118.1 - 1e-17 64.1 0.0 3.5e-07 29.6 0.0 3.5 3 0 0 3 3 3 3 Periplasmic copper-binding protein (NosD) Cellulase-like PF12876.2 KOO23119.1 - 8.8e-08 32.4 0.0 3.2e-07 30.6 0.0 2.0 2 0 0 2 2 2 1 Sugar-binding cellulase-like Cellulase PF00150.13 KOO23119.1 - 0.00011 21.4 0.0 0.00027 20.2 0.0 1.7 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Thioredoxin PF00085.15 KOO23120.1 - 2.1e-12 46.6 0.1 3.7e-11 42.6 0.0 2.3 2 1 0 2 2 2 1 Thioredoxin Arfaptin PF06456.8 KOO23120.1 - 0.00054 19.3 4.1 0.00075 18.9 2.9 1.2 1 0 0 1 1 1 1 Arfaptin-like domain DUF4618 PF15397.1 KOO23120.1 - 0.003 16.9 2.6 0.0049 16.2 1.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) Thioredoxin_2 PF13098.1 KOO23120.1 - 0.0059 16.7 0.1 0.13 12.5 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin-like domain RRF_GI PF12614.3 KOO23120.1 - 0.098 12.4 1.2 0.14 11.9 0.8 1.2 1 0 0 1 1 1 0 Ribosome recycling factor DUF342 PF03961.8 KOO23120.1 - 0.098 11.0 1.2 0.12 10.8 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Spc7 PF08317.6 KOO23120.1 - 0.18 10.4 5.5 0.24 10.0 3.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF148 PF02520.12 KOO23120.1 - 0.21 11.4 3.5 0.32 10.7 2.4 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF148 Med30 PF11315.3 KOO23120.1 - 0.28 11.3 3.4 0.4 10.7 2.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit 30 APG6 PF04111.7 KOO23120.1 - 0.32 10.0 7.6 0.42 9.6 5.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.9 KOO23120.1 - 0.32 10.5 4.7 0.41 10.2 3.3 1.1 1 0 0 1 1 1 0 IncA protein OmpH PF03938.9 KOO23120.1 - 0.72 9.7 7.2 0.24 11.3 3.2 1.5 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Mnd1 PF03962.10 KOO23120.1 - 0.83 9.2 7.0 1.1 8.8 4.8 1.1 1 0 0 1 1 1 0 Mnd1 family TMF_DNA_bd PF12329.3 KOO23120.1 - 2.3 8.0 13.6 0.33 10.7 3.8 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Ferric_reduct PF01794.14 KOO23121.1 - 0.091 12.8 0.2 0.36 10.9 0.1 1.9 2 0 0 2 2 2 0 Ferric reductase like transmembrane component Filamin PF00630.14 KOO23122.1 - 1.5e-23 83.3 0.0 1.3e-07 32.1 0.0 4.9 5 1 0 5 5 5 4 Filamin/ABP280 repeat EF-hand_6 PF13405.1 KOO23123.1 - 1.8e-07 30.4 0.2 0.0076 16.0 0.1 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO23123.1 - 3.6e-07 30.2 0.2 0.00031 20.8 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO23123.1 - 0.0001 21.3 0.3 0.048 12.9 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO23123.1 - 0.0002 20.9 0.2 0.0014 18.1 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO23123.1 - 0.039 13.3 0.7 0.22 10.9 0.2 2.3 2 0 0 2 2 2 0 EF hand DNA_pol3_a_NII PF11490.3 KOO23123.1 - 0.89 9.1 4.3 0.43 10.1 0.4 2.2 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II SNF2_N PF00176.18 KOO23124.1 - 4.7e-65 219.3 0.0 7.6e-65 218.6 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOO23124.1 - 1.9e-14 53.2 0.0 4e-13 49.0 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 KOO23124.1 - 2.3e-10 39.8 0.0 3.5e-10 39.1 0.0 1.2 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.10 KOO23124.1 - 0.00011 22.1 0.0 0.00041 20.2 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.24 KOO23124.1 - 0.0003 20.3 0.0 0.00088 18.7 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase ACT_3 PF10000.4 KOO23124.1 - 0.091 12.5 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 ACT domain His_Phos_1 PF00300.17 KOO23125.1 - 1.5e-22 80.3 0.0 4.5e-10 39.8 0.0 2.4 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) 6PF2K PF01591.13 KOO23125.1 - 2.9e-19 69.0 0.0 1.3e-17 63.5 0.0 2.1 2 0 0 2 2 2 2 6-phosphofructo-2-kinase Glyco_trans_1_4 PF13692.1 KOO23126.1 - 7.8e-13 48.7 0.0 2.7e-12 46.9 0.0 2.0 1 1 0 1 1 1 1 Glycosyl transferases group 1 FKBP_C PF00254.23 KOO23127.1 - 1.3e-12 47.5 0.0 2.1e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DAO PF01266.19 KOO23127.1 - 0.0036 16.2 0.1 0.0072 15.2 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase DUF3326 PF11805.3 KOO23128.1 - 1.2e-59 201.7 0.3 1.5e-59 201.4 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3326) Ribosomal_60s PF00428.14 KOO23128.1 - 2.9 8.3 5.7 0.52 10.7 1.2 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein MutS_V PF00488.16 KOO23129.1 - 5.1e-41 140.6 0.0 8.3e-41 139.9 0.0 1.2 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.15 KOO23129.1 - 1.6e-10 41.0 0.0 3.2e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 MutS domain I GIY-YIG PF01541.19 KOO23129.1 - 0.024 15.0 0.0 0.054 13.8 0.0 1.5 1 0 0 1 1 1 0 GIY-YIG catalytic domain CSD PF00313.17 KOO23130.1 - 2.7e-08 33.4 0.1 5.8e-08 32.3 0.1 1.5 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.6 KOO23130.1 - 0.022 14.2 0.6 0.046 13.2 0.4 1.5 1 0 0 1 1 1 0 Ribonuclease B OB domain TFIIA PF03153.8 KOO23131.1 - 5.2e-05 23.3 36.2 0.00048 20.1 25.1 2.4 1 1 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit TFIIA_gamma_C PF02751.9 KOO23131.1 - 7.7e-05 22.4 0.0 0.00016 21.4 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit BUD22 PF09073.5 KOO23131.1 - 7 5.5 15.0 9 5.2 10.4 1.1 1 0 0 1 1 1 0 BUD22 Pkinase PF00069.20 KOO23132.1 - 2.3e-52 177.7 0.0 3.1e-52 177.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RCC1 PF00415.13 KOO23132.1 - 6.3e-43 144.7 27.0 8.5e-10 38.6 0.1 9.5 9 1 1 10 10 10 7 Regulator of chromosome condensation (RCC1) repeat Pkinase_Tyr PF07714.12 KOO23132.1 - 2.7e-31 108.5 0.1 2.9e-30 105.2 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase RCC1_2 PF13540.1 KOO23132.1 - 1.3e-23 82.0 41.9 2.7e-06 26.8 1.4 6.9 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat Kinase-like PF14531.1 KOO23132.1 - 0.00026 20.0 0.0 0.0008 18.4 0.0 1.6 1 1 0 1 1 1 1 Kinase-like DUF2795 PF11387.3 KOO23132.1 - 0.084 12.7 0.0 0.24 11.3 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2795) EF-hand_1 PF00036.27 KOO23133.1 - 3.8e-34 113.3 11.1 3.2e-05 22.9 0.0 7.8 7 0 0 7 7 7 6 EF hand EF-hand_7 PF13499.1 KOO23133.1 - 7.3e-30 102.9 9.4 3.1e-10 40.0 1.0 4.5 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO23133.1 - 3.5e-26 90.5 12.5 7.1e-11 41.5 0.8 6.1 4 2 2 6 6 6 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO23133.1 - 5.2e-25 85.0 10.2 2.2e-05 23.9 0.0 7.7 7 0 0 7 7 7 6 EF-hand domain EF-hand_5 PF13202.1 KOO23133.1 - 2.5e-21 73.9 7.7 5.4e-06 25.4 0.0 6.9 6 0 0 6 6 6 4 EF hand AKAP28 PF14469.1 KOO23133.1 - 1.4e-09 37.5 0.0 2.7e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 28 kDa A-kinase anchor EF-hand_4 PF12763.2 KOO23133.1 - 3e-09 36.5 4.9 0.026 14.2 0.1 5.0 4 1 1 5 5 5 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO23133.1 - 7.7e-08 32.3 0.3 0.03 14.3 0.0 3.3 3 0 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO23133.1 - 0.00039 20.0 5.1 1.1 9.0 0.0 4.7 4 1 1 5 5 5 2 EF hand p25-alpha PF05517.7 KOO23133.1 - 0.13 12.4 0.2 4.2 7.5 0.0 2.5 2 0 0 2 2 2 0 p25-alpha DUF718 PF05336.8 KOO23134.1 - 0.029 14.1 0.0 0.06 13.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF718) Gram_pos_anchor PF00746.16 KOO23136.1 - 2.1 8.2 4.5 0.68 9.8 0.6 1.9 2 0 0 2 2 2 0 Gram positive anchor Shufflon_N PF04917.7 KOO23137.1 - 0.12 11.4 0.3 0.15 11.1 0.2 1.2 1 0 0 1 1 1 0 Bacterial shufflon protein, N-terminal constant region TGFb_propeptide PF00688.13 KOO23137.1 - 0.14 11.3 0.1 0.86 8.8 0.0 1.9 2 0 0 2 2 2 0 TGF-beta propeptide TGFb_propeptide PF00688.13 KOO23138.1 - 6.1e-05 22.4 0.2 0.031 13.5 0.1 2.3 2 0 0 2 2 2 2 TGF-beta propeptide NPV_P10 PF05531.7 KOO23139.1 - 0.12 12.6 8.1 4.2 7.6 0.2 3.9 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Nup54 PF13874.1 KOO23139.1 - 0.16 11.6 28.0 0.096 12.3 4.0 3.1 2 1 1 3 3 3 0 Nucleoporin complex subunit 54 IncA PF04156.9 KOO23139.1 - 0.21 11.1 31.5 1.3 8.6 12.5 2.5 2 1 0 2 2 2 0 IncA protein APG6 PF04111.7 KOO23139.1 - 0.61 9.0 33.3 0.12 11.3 12.0 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 IFT57 PF10498.4 KOO23139.1 - 1.2 7.8 15.1 0.071 11.8 6.0 1.8 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 DUF2096 PF09869.4 KOO23139.1 - 1.9 8.3 6.9 4.3 7.1 4.0 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2096) FimP PF09766.4 KOO23139.1 - 3.9 6.4 13.5 1 8.3 5.9 2.0 1 1 1 2 2 2 0 Fms-interacting protein NUDIX PF00293.23 KOO23140.1 - 2.7e-14 52.9 0.2 5.8e-10 38.9 0.0 2.7 2 0 0 2 2 2 2 NUDIX domain Ion_trans PF00520.26 KOO23140.1 - 1.9 7.7 6.2 0.069 12.3 0.2 1.6 2 0 0 2 2 2 0 Ion transport protein AAA PF00004.24 KOO23141.1 - 7.2e-25 87.7 0.0 3.2e-12 46.7 0.0 4.7 4 1 0 4 4 4 4 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOO23141.1 - 1.2e-14 54.5 0.0 0.0055 16.8 0.0 6.0 5 2 0 5 5 5 3 AAA domain AAA_19 PF13245.1 KOO23141.1 - 8.7e-09 35.0 1.4 0.0081 15.8 0.1 4.0 3 0 0 3 3 3 2 Part of AAA domain AAA_17 PF13207.1 KOO23141.1 - 4.1e-06 27.6 0.8 0.98 10.2 0.0 4.8 5 0 0 5 5 4 2 AAA domain AAA_28 PF13521.1 KOO23141.1 - 1.9e-05 24.6 5.1 1.4 8.9 0.1 4.5 4 0 0 4 4 4 2 AAA domain AAA_5 PF07728.9 KOO23141.1 - 3e-05 23.7 0.8 0.2 11.3 0.1 3.3 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 KOO23141.1 - 5.4e-05 22.4 0.2 0.19 10.8 0.0 2.7 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Torsin PF06309.6 KOO23141.1 - 0.00017 21.4 0.0 0.37 10.6 0.0 2.5 2 0 0 2 2 2 2 Torsin Sigma54_activat PF00158.21 KOO23141.1 - 0.00025 20.5 0.1 0.3 10.5 0.0 3.1 2 1 0 2 2 2 1 Sigma-54 interaction domain Zot PF05707.7 KOO23141.1 - 0.0011 18.5 0.1 16 4.8 0.0 4.2 4 0 0 4 4 4 0 Zonular occludens toxin (Zot) Zeta_toxin PF06414.7 KOO23141.1 - 0.0019 17.3 0.1 0.46 9.5 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_33 PF13671.1 KOO23141.1 - 0.0026 17.6 0.1 0.34 10.7 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 KOO23141.1 - 0.0057 16.9 1.5 0.46 10.7 0.0 3.1 4 0 0 4 4 2 1 AAA domain RNA_helicase PF00910.17 KOO23141.1 - 0.012 15.7 0.0 7.7 6.7 0.0 2.8 2 0 0 2 2 2 0 RNA helicase AAA_16 PF13191.1 KOO23141.1 - 0.021 14.8 16.7 0.033 14.1 0.2 5.6 4 3 0 4 4 4 0 AAA ATPase domain DUF2075 PF09848.4 KOO23141.1 - 0.022 13.7 1.5 11 4.9 0.0 3.4 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.12 KOO23141.1 - 0.038 13.4 0.0 8.6 5.7 0.0 3.1 3 0 0 3 3 3 0 IstB-like ATP binding protein EF-hand_6 PF13405.1 KOO23141.1 - 0.055 13.3 0.2 3.8 7.6 0.0 3.0 2 0 0 2 2 2 0 EF-hand domain KTI12 PF08433.5 KOO23141.1 - 0.058 12.5 0.1 8.5 5.4 0.0 2.4 2 0 0 2 2 2 0 Chromatin associated protein KTI12 NACHT PF05729.7 KOO23141.1 - 0.064 12.9 0.1 6.4 6.4 0.0 3.4 4 0 0 4 4 3 0 NACHT domain KaiC PF06745.8 KOO23141.1 - 0.2 10.7 0.0 5.9 5.9 0.0 2.5 2 0 0 2 2 2 0 KaiC DAP3 PF10236.4 KOO23141.1 - 0.22 10.4 0.0 0.53 9.1 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_11 PF13086.1 KOO23141.1 - 0.26 10.8 0.0 3.9 6.9 0.0 2.8 2 0 0 2 2 2 0 AAA domain Ion_trans PF00520.26 KOO23142.1 - 3.9e-144 476.7 35.9 5.9e-46 156.2 1.9 4.2 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 KOO23142.1 - 0.066 11.6 58.4 0.066 11.6 2.6 8.6 6 2 2 8 8 8 0 Polycystin cation channel PAN_2 PF08276.6 KOO23144.1 - 0.0024 17.6 4.8 0.011 15.5 3.2 2.2 2 1 0 2 2 2 1 PAN-like domain PAN_4 PF14295.1 KOO23144.1 - 0.0056 16.3 1.9 0.012 15.3 1.3 1.5 1 0 0 1 1 1 1 PAN domain PAN_1 PF00024.21 KOO23144.1 - 0.0057 16.3 0.1 0.017 14.8 0.1 1.8 2 0 0 2 2 2 1 PAN domain Haemolytic PF01809.13 KOO23144.1 - 0.05 13.2 0.4 0.1 12.2 0.2 1.4 1 0 0 1 1 1 0 Haemolytic domain Chromate_transp PF02417.10 KOO23145.1 - 3.1e-32 111.4 11.4 3.1e-32 111.4 7.9 2.3 3 0 0 3 3 3 2 Chromate transporter ClpS PF02617.12 KOO23146.1 - 1.2e-12 47.4 0.0 1.7e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS PAN_4 PF14295.1 KOO23147.1 - 0.011 15.4 1.4 0.02 14.6 1.0 1.4 1 0 0 1 1 1 0 PAN domain PAN_2 PF08276.6 KOO23147.1 - 0.011 15.5 2.1 0.028 14.2 1.0 2.1 3 0 0 3 3 3 0 PAN-like domain CoaE PF01121.15 KOO23148.1 - 2.4e-38 131.3 1.0 7.3e-31 106.9 0.0 2.6 2 0 0 2 2 2 2 Dephospho-CoA kinase CTP_transf_2 PF01467.21 KOO23148.1 - 8.8e-06 25.8 0.0 2.6e-05 24.3 0.0 1.9 2 0 0 2 2 2 1 Cytidylyltransferase HD PF01966.17 KOO23148.1 - 0.0037 17.2 0.3 0.0088 16.0 0.2 1.6 1 0 0 1 1 1 1 HD domain AAA_18 PF13238.1 KOO23148.1 - 0.11 12.7 0.1 10 6.4 0.3 2.3 2 0 0 2 2 2 0 AAA domain LRR_6 PF13516.1 KOO23149.1 - 6.3e-13 47.3 14.4 0.23 11.6 0.2 7.1 8 0 0 8 8 8 5 Leucine Rich repeat LRR_1 PF00560.28 KOO23149.1 - 4.3e-07 29.0 1.8 10 6.6 0.1 5.9 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_7 PF13504.1 KOO23149.1 - 1.1e-05 24.8 7.9 9.8 6.8 0.1 6.0 6 0 0 6 6 6 1 Leucine rich repeat LRR_4 PF12799.2 KOO23149.1 - 4.9e-05 22.8 13.5 0.083 12.5 0.1 4.7 4 1 0 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO23149.1 - 0.00028 20.5 6.6 1.2 8.9 0.1 4.6 3 1 0 4 4 4 1 Leucine rich repeat 5_nucleotid_C PF02872.13 KOO23149.1 - 0.14 12.1 0.1 0.56 10.1 0.0 2.0 2 0 0 2 2 2 0 5'-nucleotidase, C-terminal domain AMP-binding PF00501.23 KOO23150.1 - 6.2e-12 44.6 0.5 1e-11 43.9 0.4 1.4 1 1 0 1 1 1 1 AMP-binding enzyme GH3 PF03321.8 KOO23150.1 - 0.022 13.3 0.0 0.029 12.8 0.0 1.2 1 0 0 1 1 1 0 GH3 auxin-responsive promoter AMP-binding_C PF13193.1 KOO23150.1 - 0.022 15.6 0.4 0.036 15.0 0.3 1.4 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain SH3_2 PF07653.12 KOO23151.1 - 5.2e-12 45.0 0.0 1.1e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 KOO23151.1 - 4.6e-10 38.9 0.0 1e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 KOO23151.1 - 1.4e-08 33.9 0.1 2.8e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain MORN PF02493.15 KOO23151.1 - 0.36 10.6 7.6 0.68 9.7 0.3 4.1 3 0 0 3 3 3 0 MORN repeat CBM_20 PF00686.14 KOO23154.1 - 1.1e-12 47.4 0.0 1.3e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 Starch binding domain WW PF00397.21 KOO23155.1 - 2.3e-06 27.3 1.9 4.8e-06 26.3 1.3 1.5 1 0 0 1 1 1 1 WW domain ubiquitin PF00240.18 KOO23156.1 - 2.9e-14 52.1 0.0 1.7e-11 43.3 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.3 KOO23156.1 - 6.8e-08 32.0 0.0 7.5e-06 25.5 0.0 2.5 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.5 KOO23156.1 - 0.00014 22.3 0.1 0.035 14.6 0.0 2.5 2 0 0 2 2 2 2 WXG100 protein secretion system (Wss), protein YukD DUF1399 PF07173.7 KOO23156.1 - 0.024 14.9 0.0 0.038 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1399) Ank_2 PF12796.2 KOO23158.1 - 9.2e-15 54.7 7.5 1e-07 32.1 0.8 3.9 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO23158.1 - 8.8e-11 40.9 6.0 0.00095 19.1 0.0 5.7 5 0 0 5 5 5 3 Ankyrin repeat LRR_6 PF13516.1 KOO23158.1 - 7.7e-08 31.6 8.1 4.9 7.5 0.0 8.2 9 0 0 9 9 9 3 Leucine Rich repeat Ank_4 PF13637.1 KOO23158.1 - 1.4e-07 31.7 4.7 0.00053 20.4 0.0 4.3 3 2 2 5 5 4 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO23158.1 - 1.7e-07 30.7 13.8 1.3e-05 24.7 0.1 5.7 5 1 0 5 5 5 1 Ankyrin repeat Ank_5 PF13857.1 KOO23158.1 - 9.5e-06 25.6 9.5 0.013 15.7 0.1 5.2 4 1 1 5 5 5 3 Ankyrin repeats (many copies) SPRY PF00622.23 KOO23158.1 - 0.00035 20.6 0.0 0.00097 19.2 0.0 1.8 1 1 0 1 1 1 1 SPRY domain LRR_1 PF00560.28 KOO23158.1 - 0.00047 19.8 0.9 15 6.0 0.4 5.3 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_4 PF12799.2 KOO23158.1 - 0.16 11.6 0.3 37 4.0 0.0 3.3 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO23158.1 - 0.36 11.2 3.5 33 5.3 0.1 4.0 3 0 0 3 3 3 0 Leucine rich repeat Dispanin PF04505.7 KOO23158.1 - 0.83 9.2 3.5 18 4.9 0.3 2.9 2 0 0 2 2 2 0 Interferon-induced transmembrane protein DUF964 PF06133.6 KOO23159.1 - 1 9.4 14.4 0.092 12.7 5.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF964) Ran_BP1 PF00638.13 KOO23160.1 - 7.3e-45 151.9 4.9 1.1e-44 151.3 3.4 1.3 1 0 0 1 1 1 1 RanBP1 domain DUF1681 PF07933.9 KOO23160.1 - 0.016 14.8 0.7 0.021 14.3 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1681) WH1 PF00568.18 KOO23160.1 - 0.038 13.7 1.1 0.19 11.4 0.7 1.9 1 1 0 1 1 1 0 WH1 domain Mito_carr PF00153.22 KOO23161.1 - 3.6e-57 190.0 4.2 3.8e-19 68.2 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Ammonium_transp PF00909.16 KOO23161.1 - 0.027 12.9 0.6 0.13 10.6 0.1 2.3 3 0 0 3 3 3 0 Ammonium Transporter Family 2CSK_N PF08521.5 KOO23161.1 - 0.12 11.8 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Two-component sensor kinase N-terminal Carboxyl_trans PF01039.17 KOO23162.1 - 1.1e-139 465.9 0.0 4.2e-139 464.0 0.0 1.8 1 1 0 1 1 1 1 Carboxyl transferase domain ACC_central PF08326.7 KOO23162.1 - 1.9e-102 343.6 0.0 2.8e-102 343.1 0.0 1.2 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region CPSase_L_D2 PF02786.12 KOO23162.1 - 9.3e-47 159.0 0.0 2e-46 157.9 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.14 KOO23162.1 - 3.7e-23 81.5 0.0 2e-22 79.2 0.0 2.4 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain CPSase_L_chain PF00289.17 KOO23162.1 - 9.9e-20 70.6 0.0 2.4e-19 69.4 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain ATP-grasp_4 PF13535.1 KOO23162.1 - 9.3e-12 45.0 0.0 2.3e-11 43.7 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl PF00364.17 KOO23162.1 - 1.1e-10 40.9 0.2 3.2e-10 39.4 0.1 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.1 KOO23162.1 - 2.3e-06 26.5 0.0 0.0059 15.3 0.0 3.3 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.9 KOO23162.1 - 0.00013 21.8 0.0 0.00029 20.7 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 KOO23162.1 - 0.0076 15.6 0.0 0.016 14.6 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 KOO23162.1 - 0.016 14.5 0.0 0.061 12.6 0.0 1.9 1 1 0 1 1 1 0 ATP-grasp domain DUF4169 PF13770.1 KOO23162.1 - 4.1 7.4 4.8 0.45 10.4 0.1 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF4169) MMPL PF03176.10 KOO23163.1 - 1.9e-23 82.7 11.3 3.7e-23 81.7 7.8 1.5 1 0 0 1 1 1 1 MMPL family UQ_con PF00179.21 KOO23164.1 - 1e-35 122.2 0.0 1.4e-35 121.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 KOO23164.1 - 0.042 13.7 0.0 0.071 13.0 0.0 1.4 1 0 0 1 1 1 0 RWD domain Prok-E2_B PF14461.1 KOO23164.1 - 0.056 13.2 0.0 0.082 12.6 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B Hist_deacetyl PF00850.14 KOO23165.1 - 9e-77 258.4 0.2 1.2e-76 257.9 0.2 1.2 1 0 0 1 1 1 1 Histone deacetylase domain MMPL PF03176.10 KOO23166.1 - 4.5e-08 32.1 2.1 5.1e-08 32.0 1.0 1.4 1 1 0 1 1 1 1 MMPL family TMEM238 PF15125.1 KOO23166.1 - 0.54 10.2 3.7 0.48 10.3 0.9 1.9 1 1 1 2 2 2 0 TMEM238 protein family PDZ PF00595.19 KOO23167.1 - 1.1e-13 51.1 0.0 7.5e-06 26.0 0.0 2.5 2 1 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO23167.1 - 3.7e-09 36.3 0.8 0.0035 17.1 0.0 3.2 2 1 0 2 2 2 2 PDZ domain Beta_elim_lyase PF01212.16 KOO23167.1 - 0.0028 16.8 0.3 0.026 13.6 0.1 2.0 1 1 0 1 1 1 1 Beta-eliminating lyase DUF764 PF05561.6 KOO23167.1 - 0.14 11.5 0.0 17 4.7 0.0 2.3 2 0 0 2 2 2 0 Borrelia burgdorferi protein of unknown function (DUF764) TSC21 PF15217.1 KOO23173.1 - 0.04 13.5 0.0 0.047 13.3 0.0 1.0 1 0 0 1 1 1 0 TSC21 family Gag_spuma PF03276.9 KOO23175.1 - 0.013 13.8 4.5 0.018 13.4 3.1 1.2 1 0 0 1 1 1 0 Spumavirus gag protein Ank_2 PF12796.2 KOO23176.1 - 4.2e-30 103.9 0.4 1.9e-17 63.3 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO23176.1 - 2.7e-28 97.8 2.7 5.9e-10 39.3 0.0 5.7 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.25 KOO23176.1 - 2e-27 93.5 9.4 3.4e-07 29.7 0.0 4.9 4 1 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.1 KOO23176.1 - 2.5e-23 81.5 5.7 8.5e-08 32.2 0.1 5.0 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO23176.1 - 6.7e-19 66.1 0.8 0.0029 17.6 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat NESP55 PF06390.7 KOO23176.1 - 0.28 10.5 2.9 0.41 9.9 2.0 1.4 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) DUF791 PF05631.9 KOO23177.1 - 6.6e-74 248.7 2.3 9.4e-74 248.2 1.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF791) MFS_1 PF07690.11 KOO23177.1 - 1.6e-09 36.9 33.8 3.5e-07 29.2 9.8 2.0 1 1 0 2 2 2 2 Major Facilitator Superfamily CDC50 PF03381.10 KOO23178.1 - 7.1e-63 212.3 0.2 8.8e-43 146.4 0.0 2.4 2 1 0 2 2 2 2 LEM3 (ligand-effect modulator 3) family / CDC50 family SelR PF01641.13 KOO23179.1 - 1.1e-28 99.4 0.0 2.9e-28 98.0 0.0 1.6 1 1 0 1 1 1 1 SelR domain MOZ_SAS PF01853.13 KOO23180.1 - 3.7e-75 251.3 0.0 6e-75 250.6 0.0 1.3 1 0 0 1 1 1 1 MOZ/SAS family Acetyltransf_1 PF00583.19 KOO23180.1 - 0.0031 17.5 0.0 0.0065 16.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 KOO23180.1 - 0.023 14.4 0.0 0.044 13.5 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_7 PF13508.1 KOO23180.1 - 0.033 14.3 0.0 0.075 13.2 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain IF2_N PF04760.10 KOO23180.1 - 0.085 12.5 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region DnaJ-X PF14308.1 KOO23181.1 - 9.9e-30 103.3 0.0 3.6e-29 101.4 0.0 1.9 1 1 0 1 1 1 1 X-domain of DnaJ-containing DnaJ PF00226.26 KOO23181.1 - 7.4e-24 83.2 2.1 1.3e-23 82.4 1.5 1.5 1 0 0 1 1 1 1 DnaJ domain ATG_C PF09333.6 KOO23181.1 - 0.0045 17.1 0.9 0.014 15.5 0.0 2.2 2 0 0 2 2 2 1 ATG C terminal domain PRK PF00485.13 KOO23182.1 - 2.7e-08 33.6 0.0 2.7e-07 30.3 0.0 2.0 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family LRR_6 PF13516.1 KOO23183.1 - 8.1e-47 152.0 59.1 0.15 12.2 0.0 29.3 31 0 0 31 31 30 10 Leucine Rich repeat LRR_4 PF12799.2 KOO23183.1 - 4.9e-16 57.9 30.6 1.4 8.6 0.0 14.4 13 2 1 14 14 14 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO23183.1 - 2.4e-15 54.1 13.1 3.7 7.9 0.3 17.9 24 0 0 24 24 21 1 Leucine Rich Repeat LRR_8 PF13855.1 KOO23183.1 - 6e-11 41.9 21.7 0.035 13.8 0.0 13.7 12 5 3 15 15 15 2 Leucine rich repeat LRR_7 PF13504.1 KOO23183.1 - 1.4e-06 27.4 25.7 3.8 8.1 0.1 15.7 19 0 0 19 19 17 1 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO23183.1 - 1.3e-05 25.2 5.0 87 3.3 0.0 8.5 8 1 1 9 9 9 0 RNA 2'-O ribose methyltransferase substrate binding Metal_CEHH PF14455.1 KOO23183.1 - 0.0022 17.4 0.7 0.15 11.4 0.0 3.1 2 1 1 3 3 3 1 Predicted metal binding domain 5_nucleotid_C PF02872.13 KOO23183.1 - 0.014 15.3 0.5 0.17 11.8 0.0 2.9 2 0 0 2 2 2 0 5'-nucleotidase, C-terminal domain FIBP PF05427.6 KOO23183.1 - 0.019 14.2 0.0 5.9 6.0 0.0 2.7 3 0 0 3 3 3 0 Acidic fibroblast growth factor binding (FIBP) Dispanin PF04505.7 KOO23183.1 - 0.22 11.0 3.1 23 4.6 0.0 4.3 4 0 0 4 4 4 0 Interferon-induced transmembrane protein HCaRG PF07258.9 KOO23183.1 - 0.25 10.8 6.7 21 4.5 0.0 5.8 7 0 0 7 7 7 0 HCaRG protein DUF902 PF06001.8 KOO23183.1 - 0.49 10.5 1.3 1.6e+02 2.5 0.0 4.2 5 0 0 5 5 4 0 Domain of Unknown Function (DUF902) PAD_M PF08527.5 KOO23183.1 - 0.63 9.4 4.3 78 2.6 0.1 4.0 4 0 0 4 4 4 0 Protein-arginine deiminase (PAD) middle domain EF-hand_1 PF00036.27 KOO23184.1 - 6.6e-11 40.6 0.2 8.6e-05 21.5 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO23184.1 - 1.6e-08 34.5 0.7 9.3e-08 32.1 0.2 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO23184.1 - 2.2e-07 30.1 0.6 0.0059 16.3 0.0 3.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.1 KOO23184.1 - 2.4e-05 23.8 4.5 0.071 12.7 0.0 4.3 3 2 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO23184.1 - 0.0081 15.4 0.1 0.35 10.2 0.0 2.5 2 0 0 2 2 2 1 EF hand SPARC_Ca_bdg PF10591.4 KOO23184.1 - 0.012 15.6 0.1 0.069 13.1 0.1 2.0 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region NIPSNAP PF07978.8 KOO23185.1 - 6.5e-13 48.5 0.0 4e-07 29.9 0.0 2.3 2 0 0 2 2 2 2 NIPSNAP DIOX_N PF14226.1 KOO23186.1 - 0.094 13.2 0.0 0.13 12.7 0.0 1.2 1 0 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal Molybdopterin PF00384.17 KOO23187.1 - 0.094 11.4 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 Molybdopterin oxidoreductase DUF303 PF03629.13 KOO23188.1 - 5.8e-61 205.9 0.0 8.2e-61 205.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF303) PQ-loop PF04193.9 KOO23188.1 - 2.3e-12 46.2 6.7 5.9e-06 25.7 0.1 3.0 3 0 0 3 3 3 2 PQ loop repeat MtN3_slv PF03083.11 KOO23188.1 - 0.34 10.8 2.3 1.4 8.8 0.4 2.4 2 0 0 2 2 2 0 Sugar efflux transporter for intercellular exchange ADH_zinc_N_2 PF13602.1 KOO23189.1 - 9.8e-16 58.8 0.0 1.9e-15 57.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 KOO23189.1 - 3.1e-14 52.6 0.1 8.5e-14 51.2 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOO23189.1 - 0.0034 17.1 2.0 0.007 16.1 1.2 1.6 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain TPR_1 PF00515.23 KOO23190.1 - 3.4e-12 45.4 7.5 5.8e-06 25.6 0.1 3.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO23190.1 - 1.3e-11 43.5 6.1 0.00033 20.3 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO23190.1 - 2.2e-10 40.0 9.7 6.1e-05 22.5 0.6 2.4 2 0 0 2 2 2 2 TPR repeat TPR_7 PF13176.1 KOO23190.1 - 1.1e-09 37.3 0.2 0.00085 18.9 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO23190.1 - 4e-09 36.2 0.1 9.5e-09 35.0 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO23190.1 - 3e-07 29.7 0.1 0.021 14.5 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO23190.1 - 0.00036 21.1 7.0 0.0059 17.2 0.6 2.8 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 KOO23190.1 - 0.0011 19.2 0.6 0.54 10.8 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.1 KOO23190.1 - 0.0057 16.5 1.0 0.0057 16.5 0.7 2.6 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_3 PF07720.7 KOO23190.1 - 0.034 13.9 0.1 0.65 9.8 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO23190.1 - 0.086 13.5 6.9 1.7 9.4 0.3 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat LRR_4 PF12799.2 KOO23191.1 - 9.1e-18 63.4 26.9 0.00014 21.3 0.6 6.9 2 1 4 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO23191.1 - 4.1e-12 45.6 15.1 0.0001 22.0 1.1 4.5 3 2 1 4 4 4 4 Leucine rich repeat LRR_1 PF00560.28 KOO23191.1 - 3.2e-11 41.6 17.8 0.028 14.3 0.1 8.7 9 0 0 9 9 9 4 Leucine Rich Repeat LRR_6 PF13516.1 KOO23191.1 - 0.00016 21.4 12.8 3.2 8.1 0.0 6.8 5 1 2 7 7 7 2 Leucine Rich repeat LRR_7 PF13504.1 KOO23191.1 - 0.13 12.5 16.5 92 3.9 0.0 8.4 8 1 1 9 9 9 0 Leucine rich repeat AAA_2 PF07724.9 KOO23192.1 - 5.1e-43 146.9 1.2 1.5e-34 119.3 0.1 2.7 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA PF00004.24 KOO23192.1 - 1.2e-15 57.8 0.9 1e-06 28.9 0.1 2.7 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KOO23192.1 - 1.3e-06 28.1 0.2 4e-05 23.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 KOO23192.1 - 7.3e-06 25.9 0.1 2e-05 24.5 0.0 1.7 2 0 0 2 2 1 1 AAA domain ClpB_D2-small PF10431.4 KOO23192.1 - 9.4e-06 25.4 0.5 9.4e-06 25.4 0.3 2.0 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA_22 PF13401.1 KOO23192.1 - 1.2e-05 25.4 0.5 0.0002 21.5 0.0 2.7 2 1 0 3 3 3 1 AAA domain AAA_17 PF13207.1 KOO23192.1 - 1.2e-05 26.0 0.2 3.4e-05 24.6 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOO23192.1 - 1.6e-05 24.9 1.6 0.00011 22.3 0.1 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.1 KOO23192.1 - 6.4e-05 23.2 0.5 0.00024 21.4 0.0 2.1 2 1 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 KOO23192.1 - 0.0016 17.6 0.0 0.0068 15.5 0.0 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 KOO23192.1 - 0.0019 17.7 0.3 1.9 8.0 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 KOO23192.1 - 0.003 17.0 0.3 0.049 13.0 0.0 2.6 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_14 PF13173.1 KOO23192.1 - 0.0034 17.2 0.2 1.6 8.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 KOO23192.1 - 0.0034 17.0 0.1 0.0081 15.8 0.0 1.7 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B IstB_IS21 PF01695.12 KOO23192.1 - 0.0037 16.6 0.0 0.011 15.2 0.0 1.8 2 0 0 2 2 2 1 IstB-like ATP binding protein Zeta_toxin PF06414.7 KOO23192.1 - 0.0099 14.9 0.0 0.02 13.9 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin NACHT PF05729.7 KOO23192.1 - 0.013 15.1 0.2 2.2 7.9 0.0 2.5 2 0 0 2 2 2 0 NACHT domain GRDB PF07355.7 KOO23192.1 - 0.025 13.5 0.1 0.53 9.1 0.0 2.1 2 0 0 2 2 2 0 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) RuvB_N PF05496.7 KOO23192.1 - 0.027 13.4 1.1 1.1 8.2 0.0 2.9 2 1 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus IPT PF01745.11 KOO23192.1 - 0.028 13.5 0.3 0.2 10.7 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase SRP54 PF00448.17 KOO23192.1 - 0.034 13.5 0.7 0.071 12.5 0.0 1.8 2 1 0 2 2 2 0 SRP54-type protein, GTPase domain SKI PF01202.17 KOO23192.1 - 0.042 13.7 0.1 0.12 12.2 0.1 1.8 1 0 0 1 1 1 0 Shikimate kinase AAA_28 PF13521.1 KOO23192.1 - 0.062 13.2 0.1 0.2 11.6 0.1 1.9 1 1 0 1 1 1 0 AAA domain DEAD PF00270.24 KOO23192.1 - 0.1 12.0 3.9 0.79 9.2 0.0 2.9 2 1 0 3 3 3 0 DEAD/DEAH box helicase ATP-synt_ab PF00006.20 KOO23192.1 - 0.13 11.7 0.8 0.22 10.9 0.0 1.6 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain FAD_binding_3 PF01494.14 KOO23193.1 - 9.5e-20 70.9 0.1 1.1e-18 67.4 0.1 2.3 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 KOO23193.1 - 1.3e-05 25.1 0.1 3.2e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOO23193.1 - 9.1e-05 21.5 0.5 0.0073 15.2 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 KOO23193.1 - 0.00046 19.1 0.1 0.00094 18.1 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain SE PF08491.5 KOO23193.1 - 0.0042 15.9 0.0 0.0063 15.3 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase Amino_oxidase PF01593.19 KOO23193.1 - 0.0066 15.5 0.0 0.059 12.4 0.0 2.0 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.9 KOO23193.1 - 0.058 13.2 0.1 0.12 12.2 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.27 KOO23194.1 - 3.8e-33 110.2 15.4 6.4e-09 34.4 0.6 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO23194.1 - 9.3e-30 102.5 11.8 3.3e-16 59.1 1.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO23194.1 - 2.3e-27 92.3 11.0 1.1e-09 37.3 0.1 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 KOO23194.1 - 1.1e-26 92.1 17.3 3.3e-12 45.8 1.0 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO23194.1 - 5.1e-23 79.3 16.0 3.9e-06 25.9 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.1 KOO23194.1 - 3.9e-14 52.3 0.3 5.3e-07 29.4 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 KOO23194.1 - 1.8e-07 30.8 7.8 0.046 13.4 0.5 3.5 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand TerB PF05099.8 KOO23194.1 - 0.013 15.2 1.5 3.6 7.3 0.0 3.2 1 1 3 4 4 4 0 Tellurite resistance protein TerB SPARC_Ca_bdg PF10591.4 KOO23194.1 - 0.024 14.6 0.4 6.1 6.9 0.0 2.1 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.8 KOO23194.1 - 0.025 14.1 0.0 0.25 10.8 0.0 2.1 2 0 0 2 2 2 0 Caleosin related protein Toprim_2 PF13155.1 KOO23194.1 - 0.075 13.3 1.1 6.6 7.1 0.1 2.3 1 1 1 2 2 2 0 Toprim-like MgtE_N PF03448.12 KOO23194.1 - 0.085 13.1 0.4 0.16 12.2 0.1 1.7 2 0 0 2 2 2 0 MgtE intracellular N domain UPF0154 PF03672.8 KOO23194.1 - 0.089 12.4 0.1 2.2 7.9 0.0 2.6 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0154) EF-hand_10 PF14788.1 KOO23194.1 - 1.8 8.3 4.5 11 5.7 0.4 2.8 2 1 1 3 3 3 0 EF hand PAP_fibrillin PF04755.7 KOO23196.1 - 0.0006 19.5 0.2 0.13 11.9 0.0 2.9 3 0 0 3 3 3 2 PAP_fibrillin Nucleotid_trans PF03407.11 KOO23197.1 - 5.2e-64 215.9 0.0 3.3e-39 134.8 0.0 2.2 2 0 0 2 2 2 2 Nucleotide-diphospho-sugar transferase O-FucT PF10250.4 KOO23199.1 - 4.2e-05 22.8 0.0 0.00031 19.9 0.0 2.2 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase RRM_5 PF13893.1 KOO23201.1 - 0.0018 18.0 0.0 0.0033 17.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO23201.1 - 0.011 15.6 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOO23201.1 - 0.017 14.7 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PhyH PF05721.8 KOO23202.1 - 3.6e-23 82.7 0.0 5.4e-23 82.1 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Tnp_DNA_bind PF14706.1 KOO23202.1 - 0.094 12.4 0.0 0.38 10.5 0.0 2.0 1 0 0 1 1 1 0 Transposase DNA-binding DUF106 PF01956.11 KOO23203.1 - 5.8e-29 100.7 12.9 5.8e-29 100.7 9.0 1.5 2 0 0 2 2 2 1 Integral membrane protein DUF106 Laminin_G_3 PF13385.1 KOO23205.1 - 2.9e-16 60.0 0.2 4.3e-16 59.5 0.1 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily zf-piccolo PF05715.8 KOO23206.1 - 0.066 13.2 0.4 0.19 11.7 0.3 1.8 1 0 0 1 1 1 0 Piccolo Zn-finger EF-hand_7 PF13499.1 KOO23207.1 - 1.2e-10 41.4 1.8 6.2e-08 32.6 0.4 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO23207.1 - 1.1e-09 37.7 1.0 9.6e-05 21.9 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO23207.1 - 5.8e-09 34.6 1.1 0.0035 16.5 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO23207.1 - 5e-07 28.7 0.8 0.0022 17.2 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO23207.1 - 3.4e-06 26.4 0.7 0.0043 16.8 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain AA_permease_2 PF13520.1 KOO23208.1 - 8.4e-30 103.6 22.1 1e-29 103.3 15.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KOO23208.1 - 2.6e-17 62.3 19.8 3.7e-17 61.8 13.8 1.1 1 0 0 1 1 1 1 Amino acid permease Phosphodiest PF01663.17 KOO23209.1 - 1e-09 38.2 0.1 0.00026 20.4 0.0 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 KOO23209.1 - 0.002 17.4 0.0 0.004 16.3 0.0 1.6 1 1 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.13 KOO23209.1 - 0.057 12.8 0.0 0.14 11.4 0.0 1.6 2 0 0 2 2 2 0 Metalloenzyme superfamily CDC45 PF02724.9 KOO23209.1 - 1.6 6.6 1.9 2.9 5.8 1.3 1.3 1 0 0 1 1 1 0 CDC45-like protein EF-hand_7 PF13499.1 KOO23210.1 - 3.8e-26 90.9 2.7 3.7e-08 33.3 0.0 3.7 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO23210.1 - 6.3e-22 75.1 4.0 2.5e-05 23.2 0.0 6.2 6 0 0 6 6 6 4 EF hand EF-hand_6 PF13405.1 KOO23210.1 - 9.1e-22 74.9 8.2 7.6e-05 22.2 0.1 6.3 5 1 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.1 KOO23210.1 - 1.2e-16 59.2 8.7 0.00054 19.1 0.0 6.4 5 1 1 6 6 6 4 EF hand EF-hand_8 PF13833.1 KOO23210.1 - 9.9e-09 34.6 0.1 0.18 11.4 0.0 5.0 4 1 0 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO23210.1 - 0.0012 18.8 0.0 0.97 9.4 0.0 3.3 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.8 KOO23210.1 - 0.0078 15.7 0.1 2.4 7.6 0.0 3.1 3 0 0 3 3 3 1 Caleosin related protein EF-hand_10 PF14788.1 KOO23210.1 - 0.019 14.6 0.9 12 5.6 0.1 3.5 3 0 0 3 3 3 0 EF hand EF-hand_1 PF00036.27 KOO23211.1 - 9.2e-09 33.9 0.6 1.6e-06 26.9 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO23211.1 - 4.3e-08 33.1 0.0 6.5e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO23211.1 - 4.4e-08 32.3 1.0 5.3e-07 28.9 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.1 KOO23211.1 - 3.1e-07 29.4 2.0 0.00035 19.7 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO23211.1 - 0.00039 19.9 1.3 0.0043 16.6 0.1 2.2 1 1 1 2 2 2 1 EF-hand domain pair Peptidase_C2 PF00648.16 KOO23213.1 - 5.6e-18 64.9 0.0 8.3e-18 64.4 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease HhH-GPD PF00730.20 KOO23215.1 - 1.7e-13 50.7 0.0 3.8e-13 49.6 0.0 1.7 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 KOO23215.1 - 5.6e-05 22.6 0.1 0.00093 18.7 0.0 2.6 2 0 0 2 2 2 1 Helix-hairpin-helix motif Cytochrom_B_N PF00033.14 KOO23216.1 - 0.021 14.2 1.9 0.059 12.7 1.3 1.6 1 1 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB MFS_1 PF07690.11 KOO23216.1 - 0.021 13.5 4.2 0.049 12.3 2.9 1.6 1 1 0 1 1 1 0 Major Facilitator Superfamily Ni_hydr_CYTB PF01292.15 KOO23216.1 - 0.026 13.9 1.0 0.048 13.0 0.7 1.4 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 7tm_1 PF00001.16 KOO23216.1 - 0.059 12.5 4.4 0.091 11.8 3.0 1.3 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) SUR7 PF06687.7 KOO23216.1 - 0.1 12.1 8.2 0.06 12.8 1.6 2.0 2 0 0 2 2 2 0 SUR7/PalI family DUF898 PF05987.8 KOO23216.1 - 2.2 7.0 8.9 14 4.4 6.4 1.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF898) DUF4064 PF13273.1 KOO23216.1 - 2.9 8.0 7.5 0.8 9.8 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) DUF2101 PF09874.4 KOO23216.1 - 6.9 6.0 7.1 0.94 8.9 1.9 1.8 2 1 0 2 2 2 0 Predicted membrane protein (DUF2101) ERO1 PF04137.10 KOO23217.1 - 1.3e-43 149.4 0.0 4.7e-34 117.9 0.0 2.1 1 1 1 2 2 2 2 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) B PF02216.11 KOO23217.1 - 0.16 11.7 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 B domain YbaB_DNA_bd PF02575.11 KOO23218.1 - 1.3e-13 50.6 4.2 1.8e-13 50.2 2.9 1.1 1 0 0 1 1 1 1 YbaB/EbfC DNA-binding family 7kD_coat PF02495.12 KOO23218.1 - 0.14 11.5 1.6 0.18 11.2 0.1 1.8 2 0 0 2 2 2 0 7kD viral coat protein EF-hand_6 PF13405.1 KOO23219.1 - 7e-18 62.8 19.5 6.3e-05 22.5 0.0 5.3 5 0 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.27 KOO23219.1 - 3.4e-17 60.3 21.3 3.4e-05 22.8 0.0 5.5 6 0 0 6 6 6 4 EF hand EF-hand_7 PF13499.1 KOO23219.1 - 1e-16 60.8 11.6 1.4e-09 37.9 1.5 3.8 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO23219.1 - 2.9e-15 55.6 7.9 0.00056 19.4 0.0 4.6 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO23219.1 - 2.2e-14 52.0 18.7 3.4e-05 22.9 0.0 5.4 6 0 0 6 6 6 3 EF hand SPARC_Ca_bdg PF10591.4 KOO23219.1 - 9.9e-06 25.5 0.4 0.02 14.9 0.0 2.8 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO23219.1 - 0.0032 17.0 5.2 0.12 12.0 0.2 3.6 3 1 1 4 4 4 2 EF hand Sec16_N PF12935.2 KOO23219.1 - 0.0048 16.8 5.5 0.72 9.6 0.3 2.3 1 1 1 2 2 2 2 Vesicle coat trafficking protein Sec16 N-terminus PARP PF00644.15 KOO23219.1 - 0.0049 16.3 0.1 0.008 15.6 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain LRR_5 PF13306.1 KOO23220.1 - 4.9e-69 229.9 0.0 8.3e-35 119.3 0.0 2.1 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO23220.1 - 2.6e-19 68.7 0.0 6.6e-05 22.5 0.0 5.3 2 1 4 6 6 6 4 Leucine rich repeat DUF1068 PF06364.7 KOO23220.1 - 2.3 7.7 9.6 8.6 5.9 0.4 3.4 1 1 1 3 3 3 0 Protein of unknown function (DUF1068) EF-hand_7 PF13499.1 KOO23221.1 - 1.8e-09 37.5 1.7 3.4e-07 30.2 0.1 2.5 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO23221.1 - 8.3e-08 31.0 0.2 0.0083 15.3 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO23221.1 - 3.1e-06 26.2 2.6 0.0018 17.5 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO23221.1 - 3.5e-06 26.5 0.2 0.083 12.5 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO23221.1 - 3e-05 23.5 0.5 0.031 14.1 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain Aldo_ket_red PF00248.16 KOO23222.1 - 1.5e-21 76.4 0.0 2.4e-21 75.7 0.0 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family NT-C2 PF10358.4 KOO23222.1 - 0.12 11.8 0.0 0.3 10.5 0.0 1.7 1 0 0 1 1 1 0 N-terminal C2 in EEIG1 and EHBP1 proteins Guanylate_cyc PF00211.15 KOO23223.1 - 1.3e-21 76.7 0.4 1.7e-09 37.2 0.0 2.7 2 1 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AAA_16 PF13191.1 KOO23223.1 - 5.4e-11 42.8 1.2 5.4e-11 42.8 0.9 3.1 3 1 0 3 3 3 1 AAA ATPase domain TPR_2 PF07719.12 KOO23223.1 - 0.0012 18.5 13.0 0.28 11.1 0.0 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat NB-ARC PF00931.17 KOO23223.1 - 0.0039 16.0 0.0 1.7 7.4 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain AAA_22 PF13401.1 KOO23223.1 - 0.0046 17.0 0.0 0.58 10.3 0.0 2.9 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.22 KOO23223.1 - 0.012 15.8 0.0 0.032 14.5 0.0 1.7 1 0 0 1 1 1 0 ABC transporter UPF0079 PF02367.12 KOO23223.1 - 0.04 13.5 0.0 0.089 12.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Arch_ATPase PF01637.13 KOO23223.1 - 0.22 11.1 0.0 0.58 9.8 0.0 1.7 1 0 0 1 1 1 0 Archaeal ATPase Myb_DNA-bind_6 PF13921.1 KOO23224.1 - 1.4e-23 82.6 9.2 1.4e-17 63.4 1.1 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 KOO23224.1 - 8.5e-23 80.1 4.3 3.5e-13 49.3 0.4 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.4 KOO23224.1 - 0.015 15.4 4.9 0.9 9.7 0.3 2.6 1 1 1 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_5 PF13873.1 KOO23224.1 - 0.54 10.2 7.3 2.3 8.1 0.4 2.6 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 KOO23224.1 - 1.9 8.7 7.9 2.7 8.1 0.8 2.6 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain DUF1825 PF08855.5 KOO23225.1 - 9e-11 41.7 0.2 6.4e-09 35.7 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF1825) TPR_12 PF13424.1 KOO23226.1 - 3.5e-13 49.2 14.5 1.5e-06 27.9 1.4 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO23226.1 - 4.1e-06 26.3 7.2 0.045 13.3 1.0 3.3 1 1 2 3 3 3 3 TPR repeat TPR_16 PF13432.1 KOO23226.1 - 6.5e-06 26.6 14.6 0.00085 19.9 0.6 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO23226.1 - 8.2e-05 22.1 5.6 0.014 15.1 0.1 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO23226.1 - 0.0003 21.1 16.2 1.1 10.0 0.1 4.6 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO23226.1 - 0.0022 17.7 16.6 0.097 12.6 0.1 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.1 KOO23226.1 - 0.0094 15.8 11.0 0.013 15.3 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO23226.1 - 0.08 12.7 7.2 3.1 7.7 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO23226.1 - 0.27 11.7 0.5 0.27 11.7 0.3 4.8 4 2 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.1 KOO23226.1 - 0.67 10.3 16.4 10 6.5 4.3 3.7 1 1 2 4 4 4 0 Tetratricopeptide repeat Ion_trans_2 PF07885.11 KOO23227.1 - 1.6e-15 56.5 8.9 3.9e-13 48.9 1.6 2.5 2 0 0 2 2 2 2 Ion channel NYN PF01936.13 KOO23227.1 - 3e-05 24.3 0.0 6.3e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 NYN domain EF-hand_1 PF00036.27 KOO23227.1 - 0.00011 21.2 7.0 0.0024 17.0 0.1 3.5 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.1 KOO23227.1 - 0.00023 21.2 1.4 0.0015 18.5 0.6 2.3 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO23227.1 - 0.0099 15.6 0.0 0.0099 15.6 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.1 KOO23227.1 - 0.19 11.1 7.2 0.27 10.6 0.0 3.4 3 0 0 3 3 3 0 EF hand Ion_trans PF00520.26 KOO23227.1 - 0.25 10.5 5.1 0.78 8.9 0.3 2.3 2 0 0 2 2 2 0 Ion transport protein ELO PF01151.13 KOO23228.1 - 9.3e-48 162.7 3.5 1.1e-47 162.4 2.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family PAN_1 PF00024.21 KOO23229.1 - 0.0019 17.9 1.7 0.0034 17.1 1.2 1.4 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.1 KOO23229.1 - 1.1 9.0 7.6 2.7 7.7 5.3 1.7 1 0 0 1 1 1 0 PAN domain DUF4169 PF13770.1 KOO23230.1 - 0.041 13.8 0.4 0.094 12.6 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4169) CBM_2 PF00553.14 KOO23231.1 - 0.089 12.8 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Cellulose binding domain YchF-GTPase_C PF06071.8 KOO23232.1 - 2.8e-39 132.7 1.2 3.6e-39 132.4 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.18 KOO23232.1 - 3.9e-20 71.9 0.0 9.3e-20 70.7 0.0 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KOO23232.1 - 5.1e-08 32.3 0.3 2.4e-07 30.1 0.0 2.2 2 1 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.18 KOO23232.1 - 0.0074 16.1 0.1 6.1 6.6 0.0 2.9 1 1 2 3 3 3 2 Dynamin family AAA_17 PF13207.1 KOO23232.1 - 0.019 15.7 0.1 0.1 13.4 0.1 2.6 1 1 0 1 1 1 0 AAA domain Miro PF08477.8 KOO23232.1 - 0.032 14.7 0.0 0.098 13.1 0.0 1.9 1 1 0 1 1 1 0 Miro-like protein DUF1471 PF07338.8 KOO23232.1 - 0.81 9.3 5.5 0.45 10.1 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1471) EF-hand_1 PF00036.27 KOO23233.1 - 5.1e-05 22.2 0.1 0.014 14.6 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO23233.1 - 0.00012 21.2 0.2 0.035 13.4 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO23233.1 - 0.00054 20.0 0.0 0.001 19.1 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair 5_nucleotid_C PF02872.13 KOO23233.1 - 0.0028 17.6 0.0 0.0083 16.1 0.0 1.7 2 0 0 2 2 2 1 5'-nucleotidase, C-terminal domain EF-hand_6 PF13405.1 KOO23233.1 - 0.005 16.6 0.0 1.3 9.1 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.1 KOO23233.1 - 0.046 13.3 0.2 0.12 11.9 0.1 1.7 1 1 1 2 2 2 0 EF-hand domain pair Kinesin PF00225.18 KOO23234.1 - 1.2e-99 333.1 0.0 2.1e-99 332.4 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain PARP PF00644.15 KOO23234.1 - 1.8e-12 47.1 0.0 5.8e-12 45.4 0.0 1.9 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain AstE_AspA PF04952.9 KOO23235.1 - 4.6e-44 150.4 0.0 5.6e-44 150.1 0.0 1.0 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family DHHA1 PF02272.14 KOO23237.1 - 6.2e-05 22.6 0.0 0.66 9.7 0.0 3.1 3 0 0 3 3 3 2 DHHA1 domain DUF4267 PF14087.1 KOO23237.1 - 0.026 14.1 0.0 0.047 13.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4267) EF-hand_1 PF00036.27 KOO23238.1 - 6e-07 28.3 0.2 0.069 12.4 0.0 4.9 5 0 0 5 5 5 2 EF hand EF-hand_7 PF13499.1 KOO23238.1 - 6.6e-07 29.3 4.6 0.23 11.6 0.1 5.3 3 3 1 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO23238.1 - 2.9e-06 26.6 3.4 0.056 13.3 0.0 5.6 7 0 0 7 7 7 2 EF-hand domain EF-hand_5 PF13202.1 KOO23238.1 - 0.00013 21.1 4.2 0.094 12.0 0.0 4.2 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.1 KOO23238.1 - 0.0044 16.5 0.7 15 5.3 0.0 4.6 5 0 0 5 5 5 1 EF-hand domain pair SCA7 PF08313.7 KOO23238.1 - 0.078 12.5 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 SCA7, zinc-binding domain NHL PF01436.16 KOO23239.1 - 6.9e-05 22.6 0.1 0.032 14.2 0.0 3.4 3 0 0 3 3 3 2 NHL repeat Aa_trans PF01490.13 KOO23241.1 - 4.9e-50 170.1 12.1 5.8e-50 169.9 8.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 KOO23241.1 - 4e-06 25.9 13.4 1.6e-05 23.8 9.3 1.9 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family PI-PLC-X PF00388.14 KOO23242.1 - 1.2e-47 160.9 0.0 3.3e-47 159.5 0.0 1.7 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain NADH-u_ox-rdase PF10785.4 KOO23242.1 - 0.033 14.4 0.1 0.16 12.1 0.1 2.3 1 1 0 1 1 1 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit EF-hand_7 PF13499.1 KOO23242.1 - 0.043 13.9 0.0 0.18 11.9 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain pair PI-PLC-Y PF00387.14 KOO23243.1 - 1.7e-13 50.5 0.0 3e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain Fumble PF03630.9 KOO23244.1 - 1.9e-80 270.2 0.0 2.8e-64 217.1 0.0 2.1 2 0 0 2 2 2 2 Fumble DUF3411 PF11891.3 KOO23245.1 - 2.9e-28 98.7 0.1 3.5e-28 98.5 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3411) Orai-1 PF07856.7 KOO23247.1 - 7.9e-08 32.0 3.0 3.2e-07 30.0 0.2 2.0 2 0 0 2 2 2 1 Mediator of CRAC channel activity DUF3487 PF11990.3 KOO23247.1 - 2.4 7.5 7.7 4.5 6.7 0.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3487) AAA_16 PF13191.1 KOO23248.1 - 0.0029 17.5 0.6 0.008 16.1 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.1 KOO23248.1 - 0.02 14.3 0.0 0.043 13.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_activat PF00158.21 KOO23248.1 - 0.05 13.0 0.0 0.082 12.3 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain MobB PF03205.9 KOO23248.1 - 0.095 12.4 0.1 0.17 11.6 0.1 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Opi1 PF08618.5 KOO23248.1 - 0.34 9.7 4.2 0.55 9.0 2.9 1.3 1 0 0 1 1 1 0 Transcription factor Opi1 DUF4440 PF14534.1 KOO23249.1 - 3.7e-06 27.1 0.7 0.071 13.3 0.1 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF4440) SnoaL_3 PF13474.1 KOO23249.1 - 0.0051 16.8 0.0 2.6 8.1 0.0 2.4 2 0 0 2 2 2 2 SnoaL-like domain SnoaL_2 PF12680.2 KOO23249.1 - 0.055 13.8 2.9 2.3 8.6 0.5 2.7 2 1 1 3 3 3 0 SnoaL-like domain CSD PF00313.17 KOO23249.1 - 0.091 12.5 0.2 20 5.0 0.1 2.5 2 0 0 2 2 2 0 'Cold-shock' DNA-binding domain CaMKII_AD PF08332.5 KOO23249.1 - 0.15 11.9 0.1 17 5.2 0.0 2.6 3 0 0 3 3 3 0 Calcium/calmodulin dependent protein kinase II Association Proteasom_Rpn13 PF04683.8 KOO23252.1 - 1.3e-20 73.2 0.0 1.9e-20 72.7 0.0 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor ATP-grasp_4 PF13535.1 KOO23253.1 - 2.5e-32 112.0 0.0 4.1e-32 111.3 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 KOO23253.1 - 1.7e-07 30.3 0.0 3e-07 29.5 0.0 1.4 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.9 KOO23253.1 - 3.4e-06 27.0 0.0 5e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.14 KOO23253.1 - 0.0071 15.9 0.0 0.021 14.3 0.0 1.7 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain 2_5_RNA_ligase2 PF13563.1 KOO23254.1 - 1.5e-06 28.0 0.3 0.049 13.3 0.1 3.0 1 1 2 3 3 3 2 2'-5' RNA ligase superfamily LigT_PEase PF02834.11 KOO23254.1 - 0.00025 20.9 0.0 0.55 10.2 0.0 2.5 2 0 0 2 2 2 2 LigT like Phosphoesterase EF-hand_7 PF13499.1 KOO23257.1 - 6.3e-13 48.6 1.5 2.5e-07 30.7 0.2 2.5 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO23257.1 - 2.4e-09 36.6 0.7 1.4e-05 24.6 0.1 2.6 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO23257.1 - 9.5e-09 33.9 4.4 0.071 12.4 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO23257.1 - 2.5e-07 29.9 5.3 0.025 14.4 0.2 4.7 3 1 2 5 5 5 2 EF-hand domain EF-hand_9 PF14658.1 KOO23257.1 - 7.7e-07 28.9 0.0 0.00014 21.7 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain PK PF00224.16 KOO23258.1 - 2.6e-103 345.2 0.0 3.2e-103 344.9 0.0 1.0 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain HpcH_HpaI PF03328.9 KOO23258.1 - 0.0003 19.7 0.2 0.0012 17.7 0.1 1.9 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family GDPD_2 PF13653.1 KOO23258.1 - 0.044 13.9 0.1 0.91 9.7 0.0 2.4 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.2 KOO23259.1 - 2.3e-19 69.5 2.8 8.7e-13 48.4 0.2 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO23259.1 - 2.9e-18 64.6 0.2 2.4e-05 23.9 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.1 KOO23259.1 - 1.3e-15 55.8 0.0 0.0014 18.7 0.0 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 KOO23259.1 - 7.9e-13 48.1 0.2 0.00056 20.0 0.0 3.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO23259.1 - 8.4e-13 48.4 0.2 6.6e-07 29.6 0.1 3.1 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Pkinase PF00069.20 KOO23260.1 - 1.8e-28 99.4 0.0 5e-28 97.9 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain PARP PF00644.15 KOO23260.1 - 5e-15 55.4 0.0 1e-14 54.4 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Pkinase_Tyr PF07714.12 KOO23260.1 - 1.5e-10 40.5 0.0 3.8e-10 39.2 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Motile_Sperm PF00635.21 KOO23260.1 - 9.1e-07 28.5 0.0 0.019 14.6 0.0 2.3 2 0 0 2 2 2 2 MSP (Major sperm protein) domain Dynamin_N PF00350.18 KOO23261.1 - 4.4e-18 65.6 0.0 7e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Dynamin family Arm PF00514.18 KOO23261.1 - 1.2e-09 37.5 1.1 0.00013 21.6 0.2 3.0 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat U-box PF04564.10 KOO23261.1 - 0.00029 20.7 0.0 0.00081 19.3 0.0 1.8 1 0 0 1 1 1 1 U-box domain HEAT PF02985.17 KOO23261.1 - 0.00045 20.0 3.1 0.0011 18.8 0.0 3.3 3 0 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.1 KOO23261.1 - 0.0051 17.0 7.2 0.0051 17.0 5.0 3.4 3 1 1 4 4 4 2 HEAT repeats MMR_HSR1 PF01926.18 KOO23261.1 - 0.0076 16.2 0.0 0.038 13.9 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 KOO23261.1 - 0.061 13.8 0.0 0.28 11.7 0.0 2.1 2 0 0 2 2 2 0 Miro-like protein Arch_ATPase PF01637.13 KOO23261.1 - 0.27 10.8 0.0 0.53 9.9 0.0 1.4 1 0 0 1 1 1 0 Archaeal ATPase HEAT_EZ PF13513.1 KOO23261.1 - 3 8.4 18.7 0.095 13.2 0.8 4.5 4 1 1 5 5 5 0 HEAT-like repeat TauD PF02668.11 KOO23262.1 - 2.9e-05 23.8 0.0 2.9e-05 23.8 0.0 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family HrpB7 PF09486.5 KOO23263.1 - 0.15 11.9 3.1 9.2 6.1 0.0 3.2 3 1 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) Lzipper-MIP1 PF14389.1 KOO23263.1 - 5 7.3 7.7 11 6.2 0.1 3.7 3 2 0 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 SMC_N PF02463.14 KOO23264.1 - 1.2e-16 60.6 0.0 2.4e-11 43.2 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 KOO23264.1 - 0.01 15.7 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.1 KOO23264.1 - 0.027 14.3 0.5 0.48 10.3 0.3 2.5 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit SMC_N PF02463.14 KOO23265.1 - 9e-19 67.5 0.0 2.1e-18 66.3 0.0 1.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 KOO23265.1 - 2.7e-07 31.1 0.0 4.1e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 KOO23265.1 - 2e-05 24.0 0.0 3.5e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain NACHT PF05729.7 KOO23265.1 - 0.0038 16.8 0.0 0.012 15.2 0.0 1.9 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.1 KOO23265.1 - 0.01 15.9 0.8 0.17 12.0 0.1 2.8 2 1 0 2 2 2 0 AAA domain AAA_21 PF13304.1 KOO23265.1 - 0.012 15.5 0.0 0.016 15.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 KOO23265.1 - 0.018 15.3 0.0 0.051 13.8 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_25 PF13481.1 KOO23265.1 - 0.81 9.0 5.0 1.1 8.5 0.1 2.9 3 0 0 3 3 3 0 AAA domain Hint PF01079.15 KOO23266.1 - 1e-19 70.6 0.1 1.4e-19 70.1 0.0 1.1 1 0 0 1 1 1 1 Hint module Peptidase_M8 PF01457.11 KOO23267.1 - 9.3e-58 195.8 0.0 1e-56 192.3 0.0 2.0 2 0 0 2 2 2 2 Leishmanolysin PKD_channel PF08016.7 KOO23268.1 - 1.4e-29 102.8 15.3 9.2e-28 96.8 11.4 2.2 2 0 0 2 2 2 2 Polycystin cation channel SMI1_KNR4 PF09346.5 KOO23269.1 - 1.5e-08 34.6 0.0 2.3e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) ART PF01129.13 KOO23271.1 - 1.7e-07 30.6 0.0 3e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.9 KOO23271.1 - 6.6e-05 22.2 0.0 0.00012 21.3 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme TPR_11 PF13414.1 KOO23273.1 - 3.9e-19 68.0 6.5 7.1e-06 25.5 0.4 3.0 2 1 0 3 3 3 3 TPR repeat TPR_1 PF00515.23 KOO23273.1 - 3.2e-18 64.4 8.6 4.6e-09 35.5 0.0 3.9 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO23273.1 - 3.4e-16 57.7 6.5 2.2e-08 33.3 0.1 3.7 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO23273.1 - 1.4e-10 40.1 2.4 7.1e-07 28.5 0.0 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO23273.1 - 1e-09 38.7 3.1 7.1e-06 26.5 0.1 3.0 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO23273.1 - 3.1e-09 37.0 0.7 1.7e-06 28.2 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO23273.1 - 3.5e-09 36.4 2.2 0.0042 17.0 0.0 3.1 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOO23273.1 - 7.5e-09 35.4 2.1 1.7e-05 24.9 0.1 3.7 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO23273.1 - 2.2e-08 33.6 2.3 4.2e-06 26.5 0.1 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOO23273.1 - 5e-08 32.6 0.8 3.1e-07 30.1 0.2 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO23273.1 - 1.6e-05 25.1 3.2 0.00039 20.7 0.1 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO23273.1 - 0.00063 19.3 3.0 1.3 8.9 0.1 3.6 3 1 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO23273.1 - 0.00064 19.5 0.4 1 9.3 0.0 2.5 1 1 1 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.1 KOO23273.1 - 0.027 13.5 0.1 0.052 12.6 0.1 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Apc3 PF12895.2 KOO23273.1 - 0.032 14.3 0.8 0.032 14.3 0.6 2.4 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 FKBP_C PF00254.23 KOO23274.1 - 2.1e-19 69.3 0.0 4.7e-19 68.1 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.13 KOO23274.1 - 1.8e-06 28.0 0.0 3.6e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase SAP PF02037.22 KOO23274.1 - 0.00071 19.0 0.1 0.0013 18.1 0.1 1.5 1 0 0 1 1 1 1 SAP domain SurA_N PF09312.6 KOO23274.1 - 0.15 11.9 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 SurA N-terminal domain Auts2 PF15336.1 KOO23274.1 - 0.55 10.2 5.5 0.081 12.9 1.0 1.6 2 0 0 2 2 2 0 Autism susceptibility gene 2 protein LRR_4 PF12799.2 KOO23275.1 - 9.8e-35 117.6 26.1 1.1e-08 34.4 0.1 8.0 4 1 2 7 7 7 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO23275.1 - 7.8e-34 115.2 18.2 9.3e-09 34.9 0.3 6.4 5 1 1 6 6 6 5 Leucine rich repeat LRR_1 PF00560.28 KOO23275.1 - 1.6e-19 66.8 21.5 0.21 11.7 0.1 13.2 13 0 0 13 13 13 8 Leucine Rich Repeat PSII_BNR PF14870.1 KOO23275.1 - 0.00013 21.1 0.2 0.68 8.8 0.0 3.7 3 1 1 4 4 4 2 Photosynthesis system II assembly factor YCF48 LRR_6 PF13516.1 KOO23275.1 - 0.00035 20.3 23.8 13 6.1 0.5 9.8 11 0 0 11 11 11 2 Leucine Rich repeat LRR_7 PF13504.1 KOO23275.1 - 0.012 15.6 23.6 18 6.1 0.2 9.4 10 0 0 10 10 10 0 Leucine rich repeat FMN_dh PF01070.13 KOO23277.1 - 4.9e-120 400.6 0.0 6.2e-120 400.2 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.12 KOO23277.1 - 0.00021 20.3 0.6 0.00034 19.6 0.4 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.20 KOO23277.1 - 0.0006 18.8 1.4 0.001 18.0 1.0 1.3 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain ZF-HD_dimer PF04770.7 KOO23277.1 - 0.0088 16.0 1.7 2.7 8.1 0.2 2.4 2 0 0 2 2 2 2 ZF-HD protein dimerisation region DHO_dh PF01180.16 KOO23277.1 - 0.027 13.4 0.1 0.07 12.0 0.1 1.6 1 1 1 2 2 2 0 Dihydroorotate dehydrogenase NMO PF03060.10 KOO23277.1 - 0.059 12.5 4.8 0.055 12.6 2.4 1.6 2 0 0 2 2 2 0 Nitronate monooxygenase His_biosynth PF00977.16 KOO23277.1 - 0.12 11.6 0.0 0.3 10.3 0.0 1.6 1 1 1 2 2 2 0 Histidine biosynthesis protein ThiG PF05690.9 KOO23277.1 - 0.14 11.2 0.1 3.4 6.6 0.1 2.1 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG DUF16 PF01519.11 KOO23278.1 - 0.35 11.0 1.6 0.86 9.8 1.1 1.6 1 0 0 1 1 1 0 Protein of unknown function DUF16 Seryl_tRNA_N PF02403.17 KOO23278.1 - 6.6 6.8 13.7 3.2 7.8 5.8 2.9 3 1 1 4 4 4 0 Seryl-tRNA synthetase N-terminal domain Glycos_transf_1 PF00534.15 KOO23279.1 - 2.2e-33 115.0 0.0 4.9e-33 113.9 0.0 1.5 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 KOO23279.1 - 6.8e-17 61.8 0.0 1.7e-16 60.5 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 KOO23279.1 - 4.7e-15 56.0 0.0 1.6e-14 54.3 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.1 KOO23279.1 - 1.8e-12 47.3 0.0 4.5e-12 46.0 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 KOO23279.1 - 1e-05 25.3 0.0 1.7e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_2 PF13477.1 KOO23279.1 - 0.00043 20.1 0.0 0.00069 19.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like ATP_synt_H PF05493.8 KOO23280.1 - 2.8e-16 59.3 9.3 3.8e-16 58.9 6.4 1.1 1 0 0 1 1 1 1 ATP synthase subunit H VirB3 PF05101.8 KOO23280.1 - 0.087 12.8 2.9 0.27 11.2 0.2 2.0 1 1 1 2 2 2 0 Type IV secretory pathway, VirB3-like protein DUF1632 PF07857.7 KOO23280.1 - 0.11 11.6 1.3 0.14 11.4 0.9 1.2 1 0 0 1 1 1 0 CEO family (DUF1632) DUF751 PF05421.6 KOO23280.1 - 0.19 12.0 1.2 0.24 11.7 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF751) UPF0047 PF01894.12 KOO23283.1 - 3.1e-12 46.3 0.0 2.5e-05 24.0 0.0 2.2 2 0 0 2 2 2 2 Uncharacterised protein family UPF0047 EF-hand_1 PF00036.27 KOO23284.1 - 3.5e-35 116.6 12.9 3.5e-07 29.0 0.7 8.3 8 0 0 8 8 8 6 EF hand EF-hand_7 PF13499.1 KOO23284.1 - 8.6e-35 118.6 10.5 2.6e-11 43.4 0.1 4.6 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO23284.1 - 5.5e-33 109.8 16.2 1.3e-05 24.7 0.0 8.3 8 0 0 8 8 8 6 EF-hand domain EF-hand_5 PF13202.1 KOO23284.1 - 1.1e-23 81.4 26.5 7.5e-05 21.8 0.1 8.0 8 0 0 8 8 8 6 EF hand EF-hand_8 PF13833.1 KOO23284.1 - 1.4e-21 75.8 11.0 3.3e-08 32.9 0.2 5.4 4 2 2 6 6 6 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO23284.1 - 6.7e-08 32.5 0.0 0.0045 17.0 0.0 3.8 4 0 0 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region DNA_circ_N PF07157.7 KOO23284.1 - 0.035 14.2 0.1 8.3 6.6 0.0 3.3 3 0 0 3 3 3 0 DNA circularisation protein N-terminus EF-hand_2 PF09068.6 KOO23284.1 - 0.077 13.0 0.0 1.3 9.1 0.0 2.7 3 0 0 3 3 3 0 EF hand DUF1707 PF08044.6 KOO23284.1 - 0.1 12.3 4.1 3.2 7.5 0.1 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF1707) DUF440 PF04269.7 KOO23284.1 - 0.12 12.4 0.4 0.5 10.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF440 cNMP_binding PF00027.24 KOO23285.1 - 7.9e-14 51.2 0.4 8.9e-07 28.6 0.1 3.9 3 1 0 3 3 3 2 Cyclic nucleotide-binding domain Helicase_C PF00271.26 KOO23287.1 - 5.1e-19 67.9 0.0 4.4e-11 42.4 0.1 2.5 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.24 KOO23287.1 - 1.9e-10 40.4 0.0 3.6e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase EF-hand_7 PF13499.1 KOO23288.1 - 6.2e-07 29.4 0.4 0.062 13.4 0.1 2.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO23288.1 - 2.5e-06 26.5 0.1 0.0022 17.2 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.27 KOO23288.1 - 2.5e-06 26.4 0.1 0.017 14.4 0.0 3.1 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO23288.1 - 0.00036 20.0 0.2 0.12 12.0 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO23288.1 - 0.00045 19.8 0.2 0.28 11.1 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain PrmA PF06325.8 KOO23289.1 - 4.2e-11 42.5 0.0 6.3e-11 41.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PRMT5 PF05185.11 KOO23289.1 - 8.4e-11 41.4 0.0 1.1e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_26 PF13659.1 KOO23289.1 - 1.3e-10 41.3 0.0 3.3e-10 40.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO23289.1 - 3.5e-10 40.4 0.0 1.1e-09 38.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO23289.1 - 1.1e-08 34.7 0.0 1.7e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOO23289.1 - 1.8e-08 33.9 0.0 3.2e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.7 KOO23289.1 - 8.5e-07 29.3 0.0 1.7e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 KOO23289.1 - 3.2e-06 26.4 0.3 8e-06 25.1 0.0 1.7 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 KOO23289.1 - 2.2e-05 24.2 0.0 3.9e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 KOO23289.1 - 0.00026 20.6 0.0 0.00039 20.0 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.10 KOO23289.1 - 0.00034 20.0 0.1 0.00062 19.1 0.1 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_12 PF08242.7 KOO23289.1 - 0.0013 19.1 0.0 0.0028 18.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 KOO23289.1 - 0.0032 17.0 0.1 0.0059 16.1 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 TehB PF03848.9 KOO23289.1 - 0.0041 16.2 0.0 0.0061 15.7 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_25 PF13649.1 KOO23289.1 - 0.0049 17.2 0.0 0.013 15.8 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain PCMT PF01135.14 KOO23289.1 - 0.0068 15.9 0.2 0.011 15.3 0.2 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.13 KOO23289.1 - 0.011 14.8 0.0 0.017 14.2 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_24 PF13578.1 KOO23289.1 - 0.012 16.4 0.0 0.024 15.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_9 PF08003.6 KOO23289.1 - 0.034 12.8 0.0 0.067 11.8 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1698) RrnaAD PF00398.15 KOO23289.1 - 0.038 12.9 0.1 0.075 12.0 0.0 1.4 2 0 0 2 2 2 0 Ribosomal RNA adenine dimethylase NNMT_PNMT_TEMT PF01234.12 KOO23289.1 - 0.052 12.5 0.0 6.7 5.6 0.0 2.1 1 1 1 2 2 2 0 NNMT/PNMT/TEMT family GCD14 PF08704.5 KOO23289.1 - 0.085 12.3 0.1 0.28 10.6 0.0 1.7 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_16 PF10294.4 KOO23289.1 - 0.13 11.6 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase PDZ PF00595.19 KOO23290.1 - 5.4e-25 87.3 4.0 3.3e-06 27.1 0.1 4.3 4 0 0 4 4 4 4 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO23290.1 - 3.8e-07 29.9 0.3 1.1 9.2 0.0 4.2 4 0 0 4 4 4 3 PDZ domain UIM PF02809.15 KOO23290.1 - 0.00079 18.7 11.6 0.12 11.9 1.6 2.7 2 0 0 2 2 2 2 Ubiquitin interaction motif PDZ_1 PF12812.2 KOO23290.1 - 0.034 14.0 0.0 13 5.8 0.0 3.1 3 0 0 3 3 3 0 PDZ-like domain SOUL PF04832.7 KOO23290.1 - 0.05 13.1 0.2 0.18 11.3 0.1 1.9 2 0 0 2 2 2 0 SOUL heme-binding protein zf-NADH-PPase PF09297.6 KOO23291.1 - 1.5 8.4 14.1 0.14 11.7 4.2 2.6 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Alpha_kinase PF02816.13 KOO23292.1 - 9.6e-43 146.0 0.0 1.3e-42 145.5 0.0 1.2 1 0 0 1 1 1 1 Alpha-kinase family DEAD PF00270.24 KOO23293.1 - 2.6e-19 69.3 0.0 2.2e-16 59.8 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO23293.1 - 8.1e-14 51.2 0.1 2.1e-13 49.9 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO23293.1 - 1.9e-09 37.6 0.0 1.4e-08 34.7 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit dsrm PF00035.20 KOO23293.1 - 4e-05 24.1 0.2 0.00014 22.3 0.1 2.0 2 0 0 2 2 2 1 Double-stranded RNA binding motif DUF2383 PF09537.5 KOO23293.1 - 0.0089 16.2 0.1 0.079 13.2 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF2383) SNF2_N PF00176.18 KOO23293.1 - 0.02 13.6 0.0 0.036 12.8 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain PAS_9 PF13426.1 KOO23294.1 - 9.8e-11 41.9 0.0 1.8e-10 41.0 0.0 1.5 1 1 0 1 1 1 1 PAS domain PAS PF00989.19 KOO23294.1 - 4.1e-06 26.5 0.0 8.4e-06 25.5 0.0 1.5 1 1 0 1 1 1 1 PAS fold PAS_4 PF08448.5 KOO23294.1 - 0.00065 19.7 0.1 0.0031 17.5 0.0 1.9 1 1 0 1 1 1 1 PAS fold PAS_8 PF13188.1 KOO23294.1 - 0.0024 17.6 0.0 0.0045 16.8 0.0 1.4 1 0 0 1 1 1 1 PAS domain DUF2102 PF09875.4 KOO23294.1 - 0.088 12.3 0.1 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2102) SH3_4 PF06347.8 KOO23294.1 - 0.094 12.2 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain Laminin_G_3 PF13385.1 KOO23295.1 - 5.1e-09 36.5 0.0 6.7e-08 32.9 0.0 2.6 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Peptidase_M16 PF00675.15 KOO23295.1 - 0.0026 17.5 0.1 0.0054 16.4 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) BAGE PF08180.6 KOO23296.1 - 0.3 10.8 0.2 0.3 10.8 0.1 2.0 2 0 0 2 2 2 0 B melanoma antigen family Spectrin PF00435.16 KOO23297.1 - 0.0014 18.8 0.4 0.0017 18.6 0.3 1.2 1 0 0 1 1 1 1 Spectrin repeat LMP PF04778.7 KOO23297.1 - 0.022 14.4 0.0 0.027 14.2 0.0 1.1 1 0 0 1 1 1 0 LMP repeated region Mit_ribos_Mrp51 PF11709.3 KOO23297.1 - 0.051 12.7 0.1 0.056 12.6 0.1 1.0 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit Baculo_PEP_C PF04513.7 KOO23297.1 - 0.083 12.7 0.2 0.1 12.4 0.1 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus IncA PF04156.9 KOO23297.1 - 0.11 12.0 3.9 0.14 11.7 2.7 1.1 1 0 0 1 1 1 0 IncA protein DivIC PF04977.10 KOO23297.1 - 0.14 11.6 0.4 1.1 8.7 0.0 2.1 1 1 1 2 2 2 0 Septum formation initiator TPR_14 PF13428.1 KOO23297.1 - 0.14 12.8 2.3 1.6 9.5 0.2 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat SlyX PF04102.7 KOO23297.1 - 0.16 12.3 1.1 5 7.5 0.1 2.4 1 1 1 2 2 2 0 SlyX DUF2968 PF11180.3 KOO23297.1 - 0.65 9.3 4.9 0.77 9.1 3.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) HisKA_3 PF07730.8 KOO23297.1 - 1.9 8.9 5.5 29 5.1 3.8 2.3 1 1 0 1 1 1 0 Histidine kinase FUSC PF04632.7 KOO23297.1 - 1.9 6.7 6.0 1.9 6.8 4.2 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF3684 PF12449.3 KOO23298.1 - 2.4e-16 58.5 0.0 1.4e-06 26.2 0.0 3.0 1 1 2 3 3 3 3 Protein of unknown function (DUF3684) HATPase_c PF02518.21 KOO23298.1 - 4.3e-07 29.6 0.0 1.1e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 KOO23298.1 - 0.00048 19.7 0.0 0.00083 19.0 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ank_4 PF13637.1 KOO23299.1 - 0.00032 21.1 0.1 0.012 16.0 0.0 2.8 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO23299.1 - 0.0067 16.7 0.1 0.18 12.1 0.0 2.6 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO23299.1 - 0.05 13.8 1.0 0.72 10.2 0.0 3.3 4 1 0 4 4 4 0 Ankyrin repeat Ank PF00023.25 KOO23299.1 - 0.12 12.1 0.8 2.6 8.0 0.1 3.2 3 0 0 3 3 3 0 Ankyrin repeat EMP24_GP25L PF01105.19 KOO23300.1 - 1.6e-33 115.9 0.0 1.9e-33 115.7 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Pro_isomerase PF00160.16 KOO23301.1 - 2.3e-22 79.8 0.0 3.9e-22 79.1 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD IMS PF00817.15 KOO23302.1 - 3.1e-35 121.1 0.4 4.2e-35 120.7 0.2 1.2 1 0 0 1 1 1 1 impB/mucB/samB family IMS_HHH PF11798.3 KOO23302.1 - 0.0012 18.7 0.0 0.0029 17.5 0.0 1.7 1 0 0 1 1 1 1 IMS family HHH motif Cdd1 PF11731.3 KOO23302.1 - 0.083 12.8 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 Pathogenicity locus DUF4332 PF14229.1 KOO23302.1 - 0.12 12.3 0.1 0.12 12.3 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4332) Methyltransf_21 PF05050.7 KOO23303.1 - 7.8e-15 55.2 0.0 2.3e-14 53.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase FkbM domain TMCO5 PF14992.1 KOO23304.1 - 0.045 12.8 2.4 0.061 12.4 1.7 1.2 1 0 0 1 1 1 0 TMCO5 family Sigma70_ner PF04546.8 KOO23304.1 - 0.63 9.6 9.4 1.2 8.6 6.5 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region Nop14 PF04147.7 KOO23304.1 - 7.5 4.3 11.3 9.5 3.9 7.9 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.7 KOO23304.1 - 8.7 5.5 10.9 13 4.9 7.6 1.2 1 0 0 1 1 1 0 SDA1 Methyltransf_32 PF13679.1 KOO23305.1 - 5.9e-29 100.5 0.0 1.3e-28 99.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO23305.1 - 1.4e-06 27.9 0.0 2.7e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO23305.1 - 2.3e-06 28.1 0.2 7.5e-06 26.5 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain TRM13 PF05206.9 KOO23305.1 - 1.3e-05 24.6 0.7 0.082 12.1 0.1 3.7 4 0 0 4 4 4 2 Methyltransferase TRM13 Methyltransf_25 PF13649.1 KOO23305.1 - 0.00097 19.4 0.1 0.0022 18.3 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO23305.1 - 0.031 14.3 0.4 0.053 13.5 0.2 1.7 1 1 0 1 1 1 0 Methyltransferase domain HTH_Tnp_1 PF01527.15 KOO23305.1 - 0.037 13.9 0.2 0.084 12.8 0.2 1.5 1 0 0 1 1 1 0 Transposase PCMT PF01135.14 KOO23305.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF3651 PF12371.3 KOO23306.1 - 1e-13 51.0 0.2 5.3e-13 48.7 0.1 2.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3651) FH2 PF02181.18 KOO23308.1 - 2.2e-47 161.7 0.0 1.6e-31 109.5 0.0 3.8 2 2 0 2 2 2 2 Formin Homology 2 Domain NiFeSe_Hases PF00374.14 KOO23308.1 - 0.038 12.7 0.0 0.055 12.2 0.0 1.1 1 0 0 1 1 1 0 Nickel-dependent hydrogenase FliD_N PF02465.13 KOO23308.1 - 3.8 7.9 9.8 0.36 11.2 1.1 2.6 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Proteasome PF00227.21 KOO23309.1 - 3.4e-59 199.3 0.0 4.1e-59 199.0 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit zf-DHHC PF01529.15 KOO23310.1 - 8.7e-16 57.8 3.9 8.7e-16 57.8 2.7 1.7 1 1 1 2 2 2 1 DHHC palmitoyltransferase DSPc PF00782.15 KOO23312.1 - 9.3e-11 41.4 0.0 1.3e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 KOO23312.1 - 1.4e-07 31.6 0.0 1.6e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.22 KOO23312.1 - 0.0011 18.4 0.0 0.0013 18.0 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 KOO23312.1 - 0.0038 17.4 0.0 0.0052 17.0 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Man-6-P_recep PF02157.10 KOO23315.1 - 2.7e-10 39.7 0.0 3.8e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.5 KOO23315.1 - 0.001 18.3 0.6 0.093 11.9 0.2 2.1 2 0 0 2 2 2 2 Autophagy-related protein 27 APG6 PF04111.7 KOO23316.1 - 0.0018 17.3 14.2 0.0018 17.3 9.9 7.2 1 1 5 7 7 7 3 Autophagy protein Apg6 DnaJ PF00226.26 KOO23317.1 - 7.4e-29 99.2 0.9 2e-28 97.9 0.9 1.5 2 0 0 2 2 2 1 DnaJ domain LRR_6 PF13516.1 KOO23318.1 - 5.6e-10 38.2 3.3 1 9.6 0.2 8.5 8 1 1 9 9 9 2 Leucine Rich repeat LRR_4 PF12799.2 KOO23318.1 - 2.6e-05 23.7 0.1 0.15 11.7 0.0 4.5 3 1 0 3 3 3 1 Leucine Rich repeats (2 copies) PAS PF00989.19 KOO23318.1 - 0.0014 18.3 0.0 0.0048 16.6 0.0 1.9 1 0 0 1 1 1 1 PAS fold LRR_1 PF00560.28 KOO23318.1 - 0.022 14.7 0.3 30 5.1 0.0 5.3 6 0 0 6 6 6 0 Leucine Rich Repeat Zeta_toxin PF06414.7 KOO23318.1 - 0.061 12.4 0.1 1.1 8.3 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin PAS_9 PF13426.1 KOO23318.1 - 0.071 13.4 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 PAS domain AAA_17 PF13207.1 KOO23318.1 - 0.11 13.3 0.0 0.38 11.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain PDZ PF00595.19 KOO23319.1 - 3.3e-20 72.0 0.0 3.1e-06 27.2 0.0 3.3 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO23319.1 - 4.9e-18 64.7 0.3 8.5e-06 25.5 0.0 3.5 3 0 0 3 3 3 3 PDZ domain EF-hand_1 PF00036.27 KOO23319.1 - 1.8e-11 42.4 0.7 5.7e-05 22.1 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO23319.1 - 1.1e-08 34.2 0.8 0.00047 19.8 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO23319.1 - 3.7e-08 33.3 0.2 7.7e-08 32.3 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO23319.1 - 8.3e-07 28.5 0.4 1.7e-05 24.3 0.0 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO23319.1 - 1.3e-06 27.4 2.3 0.0035 16.6 0.3 2.5 2 0 0 2 2 2 2 EF hand Tricorn_PDZ PF14685.1 KOO23319.1 - 1.9e-06 27.5 0.0 1.6 8.6 0.0 3.6 3 0 0 3 3 3 3 Tricorn protease PDZ domain TPR_10 PF13374.1 KOO23320.1 - 6.2e-63 207.0 23.5 4.1e-12 45.6 0.1 6.6 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_12 PF13424.1 KOO23320.1 - 1.9e-56 187.9 11.6 1.5e-19 69.6 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO23320.1 - 3.2e-27 92.9 13.9 6.8e-06 25.4 0.2 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.12 KOO23320.1 - 2.6e-23 80.0 17.2 0.0001 21.9 0.5 7.0 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.1 KOO23320.1 - 3.4e-20 70.1 15.1 0.00029 20.3 0.1 6.1 6 0 0 6 6 5 5 Tetratricopeptide repeat TPR_11 PF13414.1 KOO23320.1 - 1e-19 69.9 13.1 1.8e-07 30.6 1.6 4.8 2 1 1 4 4 4 3 TPR repeat TPR_16 PF13432.1 KOO23320.1 - 7.9e-19 67.8 25.5 2.8e-07 31.0 0.9 4.7 2 1 4 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.1 KOO23320.1 - 5.3e-16 57.4 3.3 0.12 12.6 0.0 7.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.1 KOO23320.1 - 1.2e-12 46.6 9.7 0.0095 15.6 0.1 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_4 PF07721.9 KOO23320.1 - 1.7e-12 46.5 16.3 0.16 12.4 0.0 7.6 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_19 PF14559.1 KOO23320.1 - 7e-10 39.0 15.8 0.0022 18.3 0.1 4.8 1 1 4 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.1 KOO23320.1 - 2.1e-08 34.0 40.6 0.036 14.7 0.7 8.3 5 2 3 8 8 7 4 Tetratricopeptide repeat TPR_5 PF12688.2 KOO23320.1 - 9.5e-05 22.4 11.0 0.31 11.0 0.3 4.3 1 1 1 3 3 3 2 Tetratrico peptide repeat HisKA_3 PF07730.8 KOO23320.1 - 0.00012 22.3 15.2 0.78 10.1 0.0 5.5 4 1 1 5 5 5 1 Histidine kinase TPR_3 PF07720.7 KOO23320.1 - 0.0033 17.1 0.0 4.8 7.0 0.0 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat Osmo_CC PF08946.5 KOO23320.1 - 0.019 14.9 0.1 14 5.7 0.0 3.8 4 0 0 4 4 3 0 Osmosensory transporter coiled coil ApoLp-III PF07464.6 KOO23320.1 - 0.043 13.8 1.6 1.8 8.5 0.4 3.2 2 1 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) TPR_21 PF09976.4 KOO23320.1 - 0.092 12.6 5.9 16 5.4 1.1 4.2 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO23320.1 - 0.95 10.0 12.1 1.1 9.8 0.1 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF4404 PF14357.1 KOO23320.1 - 1.5 9.2 4.4 7.4 7.0 0.5 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4404) Lambda_Kil PF06301.6 KOO23320.1 - 2.5 7.6 5.8 11 5.4 0.0 4.1 4 0 0 4 4 4 0 Bacteriophage lambda Kil protein Glucosamine_iso PF01182.15 KOO23322.1 - 1.4e-26 93.4 0.0 1.9e-26 93.0 0.0 1.1 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase TPR_12 PF13424.1 KOO23324.1 - 2e-82 271.1 27.2 2.6e-16 59.3 0.0 5.3 1 1 5 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.1 KOO23324.1 - 4.3e-78 255.2 41.0 3.6e-13 48.9 0.8 9.3 9 1 1 10 10 9 8 Tetratricopeptide repeat TPR_1 PF00515.23 KOO23324.1 - 3.9e-25 86.3 6.0 0.0049 16.4 0.0 8.5 7 1 1 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.12 KOO23324.1 - 1.4e-17 62.0 14.1 0.17 11.8 0.0 8.9 7 1 1 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.1 KOO23324.1 - 2.7e-17 61.1 15.4 0.022 14.5 0.0 8.4 7 1 0 7 7 7 5 Tetratricopeptide repeat TPR_11 PF13414.1 KOO23324.1 - 1.7e-15 56.4 9.3 0.0002 20.9 0.5 5.6 2 2 3 5 5 5 5 TPR repeat TPR_17 PF13431.1 KOO23324.1 - 1.7e-15 55.8 3.3 1.1 9.6 0.0 8.3 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO23324.1 - 1.3e-13 51.2 31.1 0.00039 21.0 0.0 6.3 3 2 4 7 7 7 6 Tetratricopeptide repeat TPR_4 PF07721.9 KOO23324.1 - 3.9e-12 45.3 27.6 0.025 14.9 0.2 10.1 9 1 1 10 10 8 4 Tetratricopeptide repeat TPR_3 PF07720.7 KOO23324.1 - 8.7e-11 41.3 0.0 0.54 10.1 0.0 6.9 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO23324.1 - 1.3e-09 37.1 7.1 0.14 12.0 0.0 7.7 7 1 1 8 8 8 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO23324.1 - 4.7e-08 33.2 18.1 0.036 14.3 0.5 5.5 3 2 2 5 5 5 3 Tetratricopeptide repeat Osmo_CC PF08946.5 KOO23324.1 - 3.8e-07 30.0 8.2 2.9 8.0 0.1 6.4 6 0 0 6 6 6 2 Osmosensory transporter coiled coil Rab5-bind PF09311.6 KOO23324.1 - 0.0002 21.2 1.1 1.4 8.7 0.0 3.6 2 1 0 3 3 3 2 Rabaptin-like protein TPR_14 PF13428.1 KOO23324.1 - 0.00059 20.2 40.4 0.13 12.9 0.2 9.4 7 2 3 10 10 7 3 Tetratricopeptide repeat TPR_5 PF12688.2 KOO23324.1 - 0.00081 19.4 12.8 0.23 11.5 0.4 4.6 1 1 2 4 4 4 2 Tetratrico peptide repeat ApoLp-III PF07464.6 KOO23324.1 - 0.00083 19.4 7.5 2.3 8.2 0.1 4.9 1 1 4 5 5 5 1 Apolipophorin-III precursor (apoLp-III) YTV PF07639.6 KOO23324.1 - 0.11 12.2 0.1 0.22 11.2 0.1 1.4 1 0 0 1 1 1 0 YTV DUF3368 PF11848.3 KOO23324.1 - 0.72 9.4 12.1 21 4.7 0.0 6.4 7 1 1 8 8 8 0 Domain of unknown function (DUF3368) HisKA_3 PF07730.8 KOO23324.1 - 0.86 9.9 21.3 16 5.9 0.7 6.3 2 2 3 5 5 5 0 Histidine kinase Ion_trans PF00520.26 KOO23325.1 - 0.00096 18.4 5.4 0.00096 18.4 3.7 2.0 2 0 0 2 2 2 1 Ion transport protein Ank_3 PF13606.1 KOO23325.1 - 0.019 15.1 0.0 5 7.6 0.0 3.7 4 0 0 4 4 4 0 Ankyrin repeat Ank PF00023.25 KOO23325.1 - 0.034 13.9 0.0 2.4 8.0 0.0 3.5 4 0 0 4 4 4 0 Ankyrin repeat Ank_2 PF12796.2 KOO23325.1 - 0.073 13.4 0.0 0.61 10.4 0.0 2.2 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) Plasmid_stabil PF05016.9 KOO23326.1 - 0.13 12.6 1.7 17 5.9 0.0 2.2 2 0 0 2 2 2 0 Plasmid stabilisation system protein Sulfotransfer_3 PF13469.1 KOO23327.1 - 5.7e-07 30.5 1.9 5.7e-07 30.5 1.3 2.6 2 1 1 3 3 3 1 Sulfotransferase family Sulfotransfer_1 PF00685.22 KOO23327.1 - 2.8e-05 23.5 0.0 0.047 12.9 0.0 2.2 2 0 0 2 2 2 2 Sulfotransferase domain Sulfotransfer_3 PF13469.1 KOO23328.1 - 2.2e-06 28.6 4.1 2.2e-06 28.6 2.8 2.6 2 1 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.22 KOO23328.1 - 3.1e-05 23.3 0.0 0.047 12.9 0.0 2.2 2 0 0 2 2 2 2 Sulfotransferase domain zf-RanBP PF00641.13 KOO23329.1 - 1.3e-05 24.2 2.3 2.2e-05 23.4 1.6 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others DZR PF12773.2 KOO23329.1 - 8.2e-05 22.3 0.8 0.00015 21.4 0.6 1.4 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.1 KOO23329.1 - 0.00081 18.5 0.5 0.0017 17.5 0.4 1.6 1 0 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_2 PF13240.1 KOO23329.1 - 0.008 15.6 1.6 0.018 14.5 1.1 1.6 1 0 0 1 1 1 1 zinc-ribbon domain EmrE PF13536.1 KOO23330.1 - 0.14 12.4 6.2 0.15 12.2 4.3 1.2 1 0 0 1 1 1 0 Multidrug resistance efflux transporter Ribosomal_60s PF00428.14 KOO23330.1 - 1.5 9.2 8.0 1.8 9.0 5.5 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein TruD PF01142.13 KOO23332.1 - 3.9e-60 203.5 0.0 6.6e-56 189.5 0.0 2.9 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) DEAD PF00270.24 KOO23333.1 - 3.3e-37 127.5 0.0 4.7e-36 123.8 0.0 2.7 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO23333.1 - 2.1e-21 75.5 0.0 3.8e-21 74.7 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DBP10CT PF08147.7 KOO23333.1 - 3.5e-11 42.7 4.7 7.3e-11 41.7 3.3 1.5 1 0 0 1 1 1 1 DBP10CT (NUC160) domain ResIII PF04851.10 KOO23333.1 - 0.036 13.9 0.0 0.14 11.9 0.0 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Aha1_N PF09229.6 KOO23334.1 - 9.4e-14 51.3 0.8 3e-13 49.7 0.0 2.3 3 0 0 3 3 3 1 Activator of Hsp90 ATPase, N-terminal TPR_11 PF13414.1 KOO23334.1 - 2.1e-09 36.8 12.3 2.7e-07 30.1 3.9 3.3 2 1 2 4 4 4 3 TPR repeat TPR_2 PF07719.12 KOO23334.1 - 3.7e-07 29.5 7.3 0.047 13.6 0.0 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO23334.1 - 9e-07 28.2 6.0 0.16 11.6 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.1 KOO23334.1 - 0.00049 19.8 13.1 0.019 14.7 1.3 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO23334.1 - 0.0064 16.4 5.7 1.3 9.0 0.4 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO23334.1 - 0.22 11.4 4.6 1 9.3 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO23334.1 - 2.2 8.9 11.8 8.5 7.0 0.1 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat Galactosyl_T PF01762.16 KOO23335.1 - 1.5e-05 24.6 0.0 3.8e-05 23.3 0.0 1.7 1 1 0 1 1 1 1 Galactosyltransferase Fringe PF02434.11 KOO23335.1 - 0.08 12.1 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Fringe-like Methyltransf_21 PF05050.7 KOO23336.1 - 3.4e-09 36.8 0.0 6.6e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase FkbM domain Peroxin-3 PF04882.7 KOO23337.1 - 1.8e-26 92.8 0.3 4.4e-11 42.1 0.1 3.4 2 2 1 3 3 3 3 Peroxin-3 DUF2849 PF11011.3 KOO23337.1 - 0.076 13.2 0.1 0.22 11.8 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2849) Trehalase PF01204.13 KOO23338.1 - 1.2e-05 24.2 0.0 0.00079 18.1 0.0 2.8 2 1 0 2 2 2 2 Trehalase MOR2-PAG1_N PF14222.1 KOO23339.1 - 1.3e-11 43.9 0.3 2.9e-11 42.7 0.2 1.5 1 0 0 1 1 1 1 Cell morphogenesis N-terminal DDE_Tnp_IS1595 PF12762.2 KOO23339.1 - 0.06 13.1 0.1 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 ISXO2-like transposase domain zf-DHHC PF01529.15 KOO23340.1 - 4.3e-36 123.9 13.0 8.7e-36 122.9 9.0 1.5 1 0 0 1 1 1 1 DHHC palmitoyltransferase SKG6 PF08693.5 KOO23340.1 - 7.3 5.9 8.3 1.6 8.1 2.4 2.3 2 0 0 2 2 2 0 Transmembrane alpha-helix domain RRM_6 PF14259.1 KOO23341.1 - 2.1e-23 82.0 0.0 1.9e-10 40.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOO23341.1 - 4.7e-22 77.3 0.0 1.6e-11 43.6 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO23341.1 - 1.4e-05 24.8 0.0 0.0012 18.6 0.0 2.7 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Kinesin PF00225.18 KOO23342.1 - 7.4e-79 264.8 0.0 1.2e-78 264.1 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Tet_JBP PF12851.2 KOO23343.1 - 0.003 16.8 0.0 0.0047 16.2 0.0 1.3 1 0 0 1 1 1 1 Oxygenase domain of the 2OGFeDO superfamily Tudor-knot PF11717.3 KOO23344.1 - 0.0043 16.7 0.0 0.0096 15.6 0.0 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Prp19_bind PF06991.6 KOO23344.1 - 0.025 13.8 4.0 0.033 13.4 2.8 1.2 1 0 0 1 1 1 0 Splicing factor, Prp19-binding domain DUF3391 PF11871.3 KOO23344.1 - 4.4 7.5 9.0 2.7 8.2 4.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) Borrelia_P83 PF05262.6 KOO23344.1 - 4.7 5.3 8.0 6.5 4.9 5.6 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Filamin PF00630.14 KOO23345.1 - 9.1e-48 160.9 0.1 3.5e-17 62.8 0.0 7.2 5 2 1 6 6 6 5 Filamin/ABP280 repeat Big_1 PF02369.11 KOO23345.1 - 0.00011 22.0 3.0 0.026 14.4 0.1 4.6 5 0 0 5 5 5 1 Bacterial Ig-like domain (group 1) Neurexophilin PF06312.7 KOO23345.1 - 0.00044 19.5 0.4 0.0069 15.6 0.1 2.2 2 0 0 2 2 2 1 Neurexophilin Big_3_4 PF13754.1 KOO23345.1 - 1 9.7 3.4 26 5.2 0.0 4.7 7 0 0 7 7 7 0 Bacterial Ig-like domain (group 3) Metallophos_2 PF12850.2 KOO23346.1 - 6.9e-07 29.2 0.0 1.2e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain MOSC PF03473.12 KOO23346.1 - 0.00059 19.3 0.0 0.001 18.5 0.0 1.4 1 0 0 1 1 1 1 MOSC domain AAA PF00004.24 KOO23349.1 - 4.4e-16 59.2 0.2 1.6e-07 31.6 0.0 3.7 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KOO23349.1 - 5.1e-06 26.2 0.0 1.4e-05 24.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOO23349.1 - 8e-05 22.6 0.1 0.001 19.1 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 KOO23349.1 - 0.0002 22.1 0.0 0.0015 19.3 0.0 2.5 3 0 0 3 3 1 1 AAA domain AAA_19 PF13245.1 KOO23349.1 - 0.00046 19.8 0.3 0.002 17.8 0.0 2.2 2 0 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 KOO23349.1 - 0.0025 17.9 0.1 0.027 14.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 KOO23349.1 - 0.0035 17.2 0.0 0.01 15.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 KOO23349.1 - 0.0044 17.1 0.0 0.041 14.0 0.0 2.6 3 0 0 3 3 3 1 RNA helicase AAA_30 PF13604.1 KOO23349.1 - 0.0065 16.0 0.4 0.057 12.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.1 KOO23349.1 - 0.0067 16.3 0.0 0.02 14.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 KOO23349.1 - 0.0093 15.5 0.0 0.02 14.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.8 KOO23349.1 - 0.029 13.2 0.0 0.064 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Zeta_toxin PF06414.7 KOO23349.1 - 0.03 13.4 0.1 0.078 12.0 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin RuvB_N PF05496.7 KOO23349.1 - 0.042 12.9 0.0 0.077 12.0 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_18 PF13238.1 KOO23349.1 - 0.049 13.9 0.0 0.15 12.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 KOO23349.1 - 0.066 12.6 0.0 0.15 11.4 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_14 PF13173.1 KOO23349.1 - 0.086 12.7 0.1 0.48 10.3 0.0 2.3 3 0 0 3 3 2 0 AAA domain AAA_24 PF13479.1 KOO23349.1 - 0.18 11.3 1.1 0.47 10.0 0.1 2.1 2 0 0 2 2 2 0 AAA domain IBR PF01485.16 KOO23350.1 - 0.0007 19.4 10.0 0.0014 18.4 6.9 1.4 1 0 0 1 1 1 1 IBR domain Slu7 PF11708.3 KOO23351.1 - 1e-56 192.4 17.0 7.6e-56 189.5 11.8 2.2 1 1 0 1 1 1 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.1 KOO23351.1 - 0.0057 16.2 0.5 0.015 14.9 0.3 1.7 1 0 0 1 1 1 1 Zinc knuckle Bud13 PF09736.4 KOO23351.1 - 0.051 13.8 0.8 0.051 13.8 0.5 3.2 4 1 0 4 4 4 0 Pre-mRNA-splicing factor of RES complex zf-CCHC_5 PF14787.1 KOO23351.1 - 1.7 8.1 6.4 1.2 8.6 0.9 2.4 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Fer2 PF00111.22 KOO23352.1 - 7.3e-07 28.8 1.6 1e-06 28.3 1.1 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain DUF1364 PF07102.7 KOO23352.1 - 0.02 14.7 1.0 0.032 14.1 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1364) Pkinase PF00069.20 KOO23354.1 - 1.8e-46 158.3 0.0 2.2e-46 158.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO23354.1 - 3.8e-34 117.9 0.0 4.9e-34 117.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO23354.1 - 0.00011 21.2 0.0 0.00015 20.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 KOO23354.1 - 0.043 12.6 0.0 0.063 12.1 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 DEAD PF00270.24 KOO23355.1 - 5.7e-44 149.5 0.0 1e-43 148.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 KOO23355.1 - 1.9e-05 24.5 0.0 5.2e-05 23.1 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 KOO23355.1 - 0.012 15.7 0.2 0.16 12.1 0.2 2.4 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 KOO23355.1 - 0.14 11.9 5.1 1.2 8.9 1.8 3.2 2 1 0 2 2 2 0 Part of AAA domain CMS1 PF14617.1 KOO23355.1 - 0.15 11.0 0.0 0.7 8.9 0.0 1.8 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit ABC_membrane PF00664.18 KOO23356.1 - 1e-55 189.1 30.3 2.7e-28 99.1 7.2 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 KOO23356.1 - 1e-33 116.5 0.0 2.1e-33 115.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 KOO23356.1 - 1.1e-06 28.0 1.9 4.7e-05 22.7 1.3 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 KOO23356.1 - 0.00012 22.1 0.0 0.013 15.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 KOO23356.1 - 0.00071 19.0 0.1 0.0017 17.8 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.1 KOO23356.1 - 0.0012 18.9 0.1 0.016 15.3 0.2 2.5 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 KOO23356.1 - 0.0017 19.1 0.1 0.0048 17.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain SbcCD_C PF13558.1 KOO23356.1 - 0.0045 16.8 0.2 0.039 13.8 0.2 2.6 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.1 KOO23356.1 - 0.0065 16.4 1.0 0.029 14.3 0.6 2.2 1 1 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 KOO23356.1 - 0.011 14.9 0.0 0.02 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_18 PF13238.1 KOO23356.1 - 0.016 15.4 0.1 0.042 14.1 0.0 1.7 2 0 0 2 2 1 0 AAA domain APS_kinase PF01583.15 KOO23356.1 - 0.034 13.8 0.0 0.083 12.5 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase G-alpha PF00503.15 KOO23356.1 - 0.071 11.7 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA PF00004.24 KOO23356.1 - 0.073 13.2 1.2 0.96 9.6 0.8 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 KOO23356.1 - 0.29 10.5 2.7 3.8 6.8 1.9 2.2 1 1 0 1 1 1 0 AAA domain DUF378 PF04070.7 KOO23357.1 - 0.1 12.2 0.1 0.18 11.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF378) Methyltransf_23 PF13489.1 KOO23358.1 - 4.5e-09 36.2 0.0 4.8e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO23358.1 - 4.4e-07 30.2 0.0 5.6e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO23358.1 - 2e-06 28.1 0.0 2.6e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO23358.1 - 0.0011 18.6 0.0 0.0012 18.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO23358.1 - 0.027 14.8 0.0 0.037 14.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.13 KOO23358.1 - 0.051 12.6 0.0 0.059 12.4 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_29 PF03141.11 KOO23358.1 - 0.063 11.6 0.0 0.081 11.2 0.0 1.0 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase TIR_2 PF13676.1 KOO23359.1 - 5.8e-18 64.9 0.0 4.7e-08 33.0 0.0 3.7 2 0 0 2 2 2 2 TIR domain Proteasom_PSMB PF10508.4 KOO23359.1 - 1.8e-08 33.1 3.6 0.0011 17.3 0.3 3.5 4 0 0 4 4 4 2 Proteasome non-ATPase 26S subunit DUF2922 PF11148.3 KOO23359.1 - 0.00064 19.3 0.0 0.01 15.4 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2922) Arm PF00514.18 KOO23359.1 - 0.00084 19.0 24.6 0.21 11.4 0.0 11.7 14 0 0 14 14 14 1 Armadillo/beta-catenin-like repeat Anti-adapt_IraP PF10796.4 KOO23359.1 - 0.0017 18.6 1.7 10 6.6 0.0 4.3 3 0 0 3 3 3 2 Sigma-S stabilisation anti-adaptor protein TIR PF01582.15 KOO23359.1 - 0.013 14.9 0.3 7.6 5.9 0.0 3.1 3 0 0 3 3 3 0 TIR domain Npa1 PF11707.3 KOO23359.1 - 0.66 8.9 0.2 5.4 5.9 0.1 2.3 2 0 0 2 2 2 0 Ribosome 60S biogenesis N-terminal Dicty_spore_N PF04562.7 KOO23359.1 - 0.76 10.0 1.4 1.3 9.2 0.3 1.8 2 0 0 2 2 2 0 Dictyostelium spore coat protein, N terminus Pro_isomerase PF00160.16 KOO23360.1 - 2e-41 141.7 0.0 3.8e-41 140.8 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Glyco_transf_8 PF01501.15 KOO23361.1 - 0.0002 20.7 0.0 0.00034 20.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.3 KOO23361.1 - 0.0048 16.2 0.0 0.0065 15.8 0.0 1.3 1 0 0 1 1 1 1 Mannosyltransferase putative PP_kinase PF02503.12 KOO23362.1 - 0.0074 15.8 0.1 0.0099 15.4 0.0 1.2 1 0 0 1 1 1 1 Polyphosphate kinase middle domain YccV-like PF08755.6 KOO23364.1 - 2.7e-15 56.1 0.0 3.9e-15 55.5 0.0 1.3 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like DUF4099 PF13351.1 KOO23365.1 - 0.074 12.9 0.1 0.21 11.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4099) TPR_MLP1_2 PF07926.7 KOO23365.1 - 0.34 10.6 27.4 0.99 9.1 15.8 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF572 PF04502.8 KOO23365.1 - 2.1 7.5 12.9 2.3 7.3 8.9 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) FUSC PF04632.7 KOO23365.1 - 2.2 6.6 20.7 2.6 6.3 14.3 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Exonuc_VII_L PF02601.10 KOO23365.1 - 3.8 6.6 13.0 4.7 6.3 9.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Cauli_AT PF03233.8 KOO23365.1 - 4.9 6.8 7.0 11 5.7 1.1 2.1 1 1 1 2 2 2 0 Aphid transmission protein Macoilin PF09726.4 KOO23365.1 - 5.3 5.1 17.7 6.2 4.9 12.2 1.1 1 0 0 1 1 1 0 Transmembrane protein UPAR_LY6 PF00021.16 KOO23365.1 - 5.7 7.4 7.3 19 5.7 4.2 2.3 1 1 1 2 2 2 0 u-PAR/Ly-6 domain MscS_porin PF12795.2 KOO23365.1 - 6.1 6.0 36.5 2.2 7.5 22.7 1.9 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Asp-B-Hydro_N PF05279.6 KOO23365.1 - 9.8 5.9 10.3 12 5.5 7.2 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Aldo_ket_red PF00248.16 KOO23366.1 - 1.3e-27 96.3 0.0 1e-19 70.4 0.0 2.1 1 1 1 2 2 2 2 Aldo/keto reductase family PAP_fibrillin PF04755.7 KOO23367.1 - 6.5e-05 22.7 0.0 0.09 12.4 0.0 2.8 2 1 0 2 2 2 2 PAP_fibrillin XPA_C PF05181.7 KOO23369.1 - 1.1e-11 44.0 0.0 2.1e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 XPA protein C-terminus EF-hand_1 PF00036.27 KOO23369.1 - 6.1e-06 25.1 0.0 4.8e-05 22.3 0.1 2.2 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO23369.1 - 9e-06 25.1 0.0 6.7e-05 22.4 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.1 KOO23369.1 - 0.00039 20.4 0.1 0.0011 19.0 0.0 1.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO23369.1 - 0.0057 15.9 0.1 0.012 14.9 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 KOO23369.1 - 0.0096 15.5 0.0 0.017 14.7 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair Ank_2 PF12796.2 KOO23372.1 - 2.2e-34 117.6 9.3 4.4e-21 75.0 0.7 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO23372.1 - 4.3e-24 83.0 5.0 3.2e-09 36.1 0.7 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.1 KOO23372.1 - 3.3e-18 63.9 3.0 2.5e-07 30.2 0.4 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.1 KOO23372.1 - 5.8e-18 64.5 7.2 1.7e-09 37.6 0.6 4.1 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO23372.1 - 1.9e-17 63.2 3.5 2.7e-10 40.4 0.4 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) U-box PF04564.10 KOO23372.1 - 8.1e-13 48.1 0.0 1.4e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO23372.1 - 2.3e-06 27.0 0.1 4.2e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit DUF1110 PF06533.7 KOO23372.1 - 3.5 7.3 7.3 7.3 6.3 0.4 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1110) SHIPPO-rpt PF07004.7 KOO23373.1 - 8.6e-11 42.1 50.5 0.0037 18.0 1.5 10.6 10 2 0 10 10 10 7 Sperm-tail PG-rich repeat CHAD PF05235.9 KOO23373.1 - 0.071 12.6 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 CHAD domain ECR1_N PF14382.1 KOO23373.1 - 4.2 6.7 9.7 18 4.7 0.0 5.4 7 0 0 7 7 7 0 Exosome complex exonuclease RRP4 N-terminal region VWA_2 PF13519.1 KOO23374.1 - 9.7e-13 48.5 0.0 9.7e-13 48.5 0.0 3.1 4 0 0 4 4 4 1 von Willebrand factor type A domain VWA PF00092.23 KOO23374.1 - 5e-09 36.1 0.0 1.5e-08 34.5 0.0 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain AAA PF00004.24 KOO23374.1 - 1.5e-08 34.8 0.1 1.4e-05 25.3 0.0 4.6 5 0 0 5 5 5 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOO23374.1 - 0.00012 22.2 0.1 0.67 10.1 0.0 4.5 5 0 0 5 5 5 2 AAA domain Arch_ATPase PF01637.13 KOO23374.1 - 0.15 11.7 0.0 0.43 10.2 0.0 1.8 1 0 0 1 1 1 0 Archaeal ATPase AAA_11 PF13086.1 KOO23374.1 - 0.22 11.0 0.0 6 6.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain Bunya_RdRp PF04196.7 KOO23374.1 - 3.4 5.5 0.1 5.5 4.8 0.1 1.2 1 0 0 1 1 1 0 Bunyavirus RNA dependent RNA polymerase Exostosin PF03016.10 KOO23375.1 - 0.0037 16.3 0.1 0.017 14.1 0.0 1.9 2 0 0 2 2 2 1 Exostosin family GBP PF02263.14 KOO23376.1 - 4.4e-64 216.0 0.0 5.6e-64 215.6 0.0 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.9 KOO23376.1 - 5.7e-12 45.4 0.0 8.1e-12 44.9 0.0 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain RHD3 PF05879.7 KOO23376.1 - 0.042 11.7 0.0 0.064 11.1 0.0 1.2 1 0 0 1 1 1 0 Root hair defective 3 GTP-binding protein (RHD3) Pkinase PF00069.20 KOO23377.1 - 0.00026 20.2 0.0 0.00042 19.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF1811 PF08838.5 KOO23378.1 - 0.19 11.6 1.5 0.52 10.2 0.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1811) HALZ PF02183.13 KOO23378.1 - 1.7 8.4 5.6 0.57 9.9 0.7 2.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper ThiF PF00899.16 KOO23379.1 - 8.1e-54 181.1 0.0 1.3e-38 131.9 0.0 2.4 2 0 0 2 2 2 2 ThiF family UBACT PF02134.16 KOO23379.1 - 2.9e-32 110.0 0.0 1.9e-26 91.4 0.0 2.5 2 0 0 2 2 2 2 Repeat in ubiquitin-activating (UBA) protein UBA_e1_C PF09358.5 KOO23379.1 - 1.8e-24 86.2 0.0 2.9e-24 85.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme e1 C-terminal domain UBA_e1_thiolCys PF10585.4 KOO23379.1 - 9.4e-20 69.7 0.7 9e-19 66.5 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site 2-Hacid_dh_C PF02826.14 KOO23379.1 - 0.041 13.0 0.0 6 5.9 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 KOO23379.1 - 0.1 12.6 0.5 1.9 8.5 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Filamin PF00630.14 KOO23380.1 - 2.8e-53 178.6 0.0 6e-19 68.4 0.0 7.5 7 1 0 7 7 7 7 Filamin/ABP280 repeat Big_1 PF02369.11 KOO23380.1 - 1.2e-06 28.3 2.0 0.59 10.0 0.0 3.9 4 0 0 4 4 4 3 Bacterial Ig-like domain (group 1) Big_3_4 PF13754.1 KOO23380.1 - 1.7e-06 28.2 9.0 0.082 13.2 0.0 5.4 7 0 0 7 7 7 3 Bacterial Ig-like domain (group 3) YtkA PF13115.1 KOO23380.1 - 0.016 15.5 0.1 4.2 7.7 0.0 3.7 3 0 0 3 3 3 0 YtkA-like DUF3603 PF12227.3 KOO23380.1 - 0.36 9.9 0.0 0.79 8.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3603) Thioredoxin PF00085.15 KOO23381.1 - 6.6e-09 35.3 0.0 1.8e-08 34.0 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_6 PF13848.1 KOO23381.1 - 0.0013 18.5 0.1 0.035 13.9 0.0 2.6 2 1 1 3 3 3 1 Thioredoxin-like domain Mod_r PF07200.8 KOO23381.1 - 0.14 12.0 4.6 0.19 11.6 3.2 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein zf-DHHC PF01529.15 KOO23382.1 - 4.8e-38 130.2 7.2 4.8e-38 130.2 5.0 1.4 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF2208 PF09973.4 KOO23382.1 - 0.2 10.8 3.8 1.7 7.8 1.2 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) DUF3568 PF12092.3 KOO23383.1 - 0.027 14.2 0.8 0.036 13.7 0.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3568) MFS_3 PF05977.8 KOO23383.1 - 0.036 12.2 1.9 0.039 12.0 1.3 1.0 1 0 0 1 1 1 0 Transmembrane secretion effector TOBE PF03459.12 KOO23383.1 - 0.25 11.4 7.0 0.28 11.3 3.2 2.3 1 1 1 2 2 2 0 TOBE domain KdpC PF02669.10 KOO23383.1 - 0.47 10.1 4.0 0.51 10.0 2.8 1.1 1 0 0 1 1 1 0 K+-transporting ATPase, c chain Bactofilin PF04519.8 KOO23383.1 - 0.71 9.9 4.3 1.4 8.9 3.0 1.6 1 1 0 1 1 1 0 Polymer-forming cytoskeletal DUF3234 PF11572.3 KOO23383.1 - 0.85 9.7 3.9 15 5.7 0.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3234) AP2 PF00847.15 KOO23385.1 - 9.6e-06 25.6 1.8 0.0018 18.4 0.2 5.2 6 2 0 6 6 6 2 AP2 domain IF3_N PF05198.11 KOO23385.1 - 0.0019 18.0 0.5 3.1 7.7 0.0 3.4 3 0 0 3 3 3 1 Translation initiation factor IF-3, N-terminal domain DUF2960 PF11173.3 KOO23385.1 - 0.009 16.2 1.2 31 4.9 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2960) VARLMGL PF14383.1 KOO23385.1 - 0.16 11.1 0.4 18 4.5 0.0 2.4 2 0 0 2 2 2 0 DUF761-associated sequence motif DUF1906 PF08924.6 KOO23385.1 - 0.19 11.6 1.1 3.7 7.4 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1906) PepSY PF03413.14 KOO23385.1 - 0.84 10.3 2.9 38 5.0 0.1 3.2 3 0 0 3 3 3 0 Peptidase propeptide and YPEB domain DnaB_bind PF10410.4 KOO23385.1 - 5.7 7.0 9.4 18 5.4 0.0 3.3 3 0 0 3 3 3 0 DnaB-helicase binding domain of primase Glyco_hydro_3_C PF01915.17 KOO23386.1 - 9.3e-50 169.2 0.0 1.7e-49 168.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.16 KOO23386.1 - 8e-43 146.5 0.0 1.1e-42 146.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.1 KOO23386.1 - 2.9e-13 49.5 0.0 5.6e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Filamin PF00630.14 KOO23387.1 - 5.6e-67 222.6 0.0 1.7e-16 60.6 0.0 7.5 7 0 0 7 7 7 6 Filamin/ABP280 repeat YtkA PF13115.1 KOO23387.1 - 1.1e-05 25.6 1.8 0.12 12.7 0.1 4.1 3 1 0 3 3 3 2 YtkA-like Big_1 PF02369.11 KOO23387.1 - 0.0023 17.8 7.3 2.8 7.8 0.0 5.2 4 1 1 5 5 5 2 Bacterial Ig-like domain (group 1) Neurexophilin PF06312.7 KOO23387.1 - 0.058 12.6 0.1 0.22 10.7 0.0 2.0 3 0 0 3 3 3 0 Neurexophilin peroxidase PF00141.18 KOO23388.1 - 5.7e-25 88.1 0.1 9.4e-25 87.4 0.1 1.3 1 1 0 1 1 1 1 Peroxidase PAP_fibrillin PF04755.7 KOO23389.1 - 2.7e-05 23.9 0.0 0.028 14.1 0.0 2.2 2 0 0 2 2 2 2 PAP_fibrillin MFS_1 PF07690.11 KOO23391.1 - 3.2e-31 108.3 19.5 4.1e-31 107.9 13.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KOO23391.1 - 0.0012 17.5 1.5 0.0017 17.0 1.1 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter DUF1228 PF06779.9 KOO23391.1 - 0.17 11.9 9.5 0.074 13.0 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1228) Abhydrolase_5 PF12695.2 KOO23393.1 - 9.5e-06 25.4 0.1 1.3e-05 24.9 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO23393.1 - 1.1e-05 25.4 3.2 5.2e-05 23.2 2.2 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF818 PF05677.7 KOO23393.1 - 0.00018 20.3 0.0 0.00034 19.4 0.0 1.4 1 1 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Abhydrolase_1 PF00561.15 KOO23393.1 - 0.0029 17.2 0.1 0.0074 15.8 0.0 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 KOO23393.1 - 0.019 14.3 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.16 KOO23393.1 - 0.062 12.5 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family DUF829 PF05705.9 KOO23393.1 - 0.13 11.9 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) CTDII PF01556.13 KOO23394.1 - 0.012 15.5 0.0 13 5.8 0.0 3.0 1 1 2 3 3 3 0 DnaJ C terminal domain NPCBM_assoc PF10633.4 KOO23394.1 - 0.028 14.4 0.9 9.9 6.2 0.0 3.0 1 1 2 3 3 3 0 NPCBM-associated, NEW3 domain of alpha-galactosidase DUF3982 PF13138.1 KOO23394.1 - 0.2 11.5 3.2 3.2 7.7 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3982) DUF3577 PF12101.3 KOO23395.1 - 0.0017 18.2 0.1 12 5.7 0.0 3.8 3 1 1 4 4 4 2 Protein of unknown function (DUF3577) NUMOD1 PF07453.8 KOO23395.1 - 0.0066 16.2 0.1 14 5.7 0.0 3.5 3 0 0 3 3 3 1 NUMOD1 domain HTH_17 PF12728.2 KOO23395.1 - 0.024 14.9 0.1 51 4.2 0.0 3.4 3 0 0 3 3 3 0 Helix-turn-helix domain AT_hook PF02178.14 KOO23396.1 - 3.5 7.6 9.6 7.6 6.5 1.0 3.9 3 0 0 3 3 3 0 AT hook motif DUF1917 PF08939.5 KOO23397.1 - 3e-26 92.6 0.8 3e-26 92.6 0.6 3.3 3 2 0 3 3 3 1 Domain of unknown function (DUF1917) Transglut_core2 PF13369.1 KOO23398.1 - 4.4e-05 23.0 0.2 8.4e-05 22.0 0.1 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF179 PF02622.10 KOO23398.1 - 0.0012 18.5 0.0 0.023 14.3 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized ACR, COG1678 FAD_binding_3 PF01494.14 KOO23400.1 - 7.6e-08 31.7 0.1 0.00023 20.3 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain SE PF08491.5 KOO23400.1 - 0.18 10.6 0.0 0.27 10.0 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase MMR_HSR1 PF01926.18 KOO23401.1 - 8.5e-18 64.4 0.0 1.9e-17 63.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.16 KOO23401.1 - 1.9e-15 56.4 0.2 3.6e-15 55.5 0.1 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.13 KOO23401.1 - 2e-10 40.1 0.0 3.9e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 KOO23401.1 - 0.0001 22.1 0.1 0.0027 17.5 0.0 2.5 1 1 1 2 2 2 1 Dynamin family Miro PF08477.8 KOO23401.1 - 0.012 16.1 0.1 0.042 14.3 0.0 2.0 2 0 0 2 2 2 0 Miro-like protein GTP_EFTU PF00009.22 KOO23401.1 - 0.013 14.8 0.0 0.6 9.5 0.0 2.8 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain ArgK PF03308.11 KOO23401.1 - 0.046 12.4 0.1 0.51 9.0 0.0 2.5 3 0 0 3 3 3 0 ArgK protein UPF0175 PF03683.8 KOO23401.1 - 0.068 12.6 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0175) ThiS PF02597.15 KOO23402.1 - 7.7 7.0 7.3 5.2 7.5 0.0 3.5 3 1 0 3 3 3 0 ThiS family ThiF PF00899.16 KOO23403.1 - 1.3e-12 47.6 0.1 2.1e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 ThiF family MoeZ_MoeB PF05237.8 KOO23403.1 - 0.0082 15.7 0.0 0.02 14.5 0.0 1.5 1 0 0 1 1 1 1 MoeZ/MoeB domain CS PF04969.11 KOO23404.1 - 4.6e-12 46.3 0.0 7.8e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 CS domain HSP20 PF00011.16 KOO23404.1 - 0.069 13.0 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Hsp20/alpha crystallin family DNA_pol3_gamma3 PF12169.3 KOO23405.1 - 0.089 12.5 0.4 0.24 11.1 0.1 1.8 2 0 0 2 2 2 0 DNA polymerase III subunits gamma and tau domain III RRM_1 PF00076.17 KOO23406.1 - 2.6e-38 129.5 0.0 8.3e-20 70.2 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO23406.1 - 2.5e-22 78.6 0.0 1.4e-11 44.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO23406.1 - 1.4e-18 66.4 0.0 9.7e-09 34.9 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.6 KOO23406.1 - 0.0062 16.0 0.3 0.42 10.1 0.0 2.5 2 0 0 2 2 2 1 Ribonuclease B OB domain Epimerase PF01370.16 KOO23408.1 - 1.2e-17 64.2 0.0 1.5e-17 63.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 KOO23408.1 - 2.8e-10 40.4 0.0 5.2e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding RmlD_sub_bind PF04321.12 KOO23408.1 - 7.2e-07 28.3 0.0 1e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Sec23_trunk PF04811.10 KOO23410.1 - 3.1e-06 26.7 0.0 2e-05 24.0 0.0 2.2 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain NAD_Gly3P_dh_C PF07479.9 KOO23412.1 - 3.2e-50 169.7 0.2 4.6e-50 169.1 0.1 1.2 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.18 KOO23412.1 - 5.6e-35 120.3 0.0 1.2e-34 119.3 0.0 1.5 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Nucleo_P87 PF07267.6 KOO23413.1 - 0.25 9.9 2.3 0.34 9.5 1.6 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 TPR_10 PF13374.1 KOO23414.1 - 2.2 8.3 6.2 0.54 10.2 0.5 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat Scramblase PF03803.10 KOO23415.1 - 9.2e-14 51.0 0.0 1.4e-07 30.8 0.0 2.3 2 0 0 2 2 2 2 Scramblase Peptidase_C74 PF12387.3 KOO23415.1 - 0.0037 16.4 0.0 0.0065 15.6 0.0 1.3 1 0 0 1 1 1 1 Pestivirus NS2 peptidase Pkinase PF00069.20 KOO23417.1 - 3.1e-52 177.3 0.0 8e-52 175.9 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO23417.1 - 1.4e-22 80.0 0.0 2.1e-18 66.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.9 KOO23417.1 - 0.0062 15.6 0.0 0.015 14.3 0.0 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 KOO23417.1 - 0.016 14.1 0.0 0.078 11.9 0.0 2.0 3 0 0 3 3 3 0 Kinase-like Pox_ser-thr_kin PF05445.6 KOO23417.1 - 0.32 9.7 0.0 0.45 9.2 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase EF-hand_6 PF13405.1 KOO23419.1 - 1.5e-10 40.0 0.2 0.00057 19.5 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO23419.1 - 9e-10 37.1 0.1 0.00029 19.9 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO23419.1 - 1.6e-08 34.5 0.0 3.6e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO23419.1 - 4.1e-07 29.5 0.0 2e-05 24.1 0.0 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO23419.1 - 4.4e-07 28.9 0.7 0.01 15.1 0.1 2.7 2 0 0 2 2 2 2 EF hand Sigma54_activat PF00158.21 KOO23419.1 - 0.056 12.9 0.8 0.11 11.9 0.6 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain 14-3-3 PF00244.15 KOO23420.1 - 7.7e-102 339.3 4.6 8.6e-102 339.2 3.2 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.1 KOO23420.1 - 0.057 13.3 4.0 1.3 8.9 0.2 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat Nuc_sug_transp PF04142.10 KOO23421.1 - 1.2e-65 221.0 14.2 2.1e-65 220.2 9.8 1.4 1 0 0 1 1 1 1 Nucleotide-sugar transporter EmrE PF13536.1 KOO23421.1 - 9e-07 29.0 6.5 9e-07 29.0 4.5 3.7 1 1 2 3 3 3 1 Multidrug resistance efflux transporter EamA PF00892.15 KOO23421.1 - 2.2e-06 27.6 2.3 2.2e-06 27.6 1.6 2.6 2 1 0 2 2 2 1 EamA-like transporter family TPT PF03151.11 KOO23421.1 - 3.8e-05 23.3 3.1 3.8e-05 23.3 2.2 3.3 2 1 0 2 2 2 1 Triose-phosphate Transporter family TraT PF05818.7 KOO23421.1 - 0.012 15.0 0.8 0.037 13.4 0.6 1.9 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein DIM1 PF02966.11 KOO23422.1 - 6.9e-68 226.2 0.1 7.8e-68 226.0 0.0 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.15 KOO23422.1 - 0.019 14.6 0.0 0.025 14.2 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin PhyH PF05721.8 KOO23423.1 - 2.1e-13 50.8 0.0 3.6e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) EmrE PF13536.1 KOO23424.1 - 8.9e-09 35.5 1.7 8.9e-09 35.5 1.2 3.5 4 1 1 5 5 5 1 Multidrug resistance efflux transporter EamA PF00892.15 KOO23424.1 - 1.4e-06 28.3 1.9 1.4e-06 28.3 1.3 3.7 3 1 0 3 3 3 1 EamA-like transporter family UAA PF08449.6 KOO23424.1 - 3.3e-06 26.2 3.8 2.9e-05 23.1 0.7 2.5 2 1 0 2 2 2 1 UAA transporter family TPT PF03151.11 KOO23424.1 - 3.4e-05 23.5 3.0 3.4e-05 23.5 2.1 2.7 2 2 0 2 2 2 1 Triose-phosphate Transporter family Nuc_sug_transp PF04142.10 KOO23424.1 - 0.00067 18.8 0.4 0.0013 17.8 0.2 1.4 1 0 0 1 1 1 1 Nucleotide-sugar transporter DUF914 PF06027.7 KOO23424.1 - 0.0029 16.5 4.9 0.012 14.5 0.7 2.4 2 1 0 2 2 2 1 Eukaryotic protein of unknown function (DUF914) UPF0546 PF10639.4 KOO23424.1 - 0.024 14.4 0.6 0.17 11.7 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0546 NHL PF01436.16 KOO23425.1 - 0.0003 20.5 1.0 4.6 7.3 0.0 5.1 5 0 0 5 5 5 1 NHL repeat DnaJ PF00226.26 KOO23425.1 - 0.0023 17.6 0.0 0.0083 15.8 0.0 2.0 1 0 0 1 1 1 1 DnaJ domain GFO_IDH_MocA PF01408.17 KOO23426.1 - 7.5e-30 103.9 0.2 1.5e-29 102.9 0.2 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.19 KOO23426.1 - 0.00047 20.4 0.1 0.00091 19.5 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain GFO_IDH_MocA_C PF02894.12 KOO23426.1 - 0.015 15.1 0.0 0.037 13.8 0.0 1.8 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain DEDD_Tnp_IS110 PF01548.12 KOO23426.1 - 0.072 12.7 0.1 0.14 11.8 0.1 1.4 1 0 0 1 1 1 0 Transposase Shikimate_DH PF01488.15 KOO23426.1 - 0.13 12.3 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Trypsin_2 PF13365.1 KOO23427.1 - 1.6e-20 73.2 2.2 3e-20 72.3 1.5 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.21 KOO23427.1 - 1.9e-14 53.7 0.2 3.1e-14 53.1 0.2 1.3 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.1 KOO23427.1 - 1.5e-11 43.9 0.0 4.1e-11 42.5 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.19 KOO23427.1 - 9.2e-07 28.9 0.0 2.3e-06 27.7 0.0 1.8 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Peptidase_S46 PF10459.4 KOO23427.1 - 0.00048 18.6 1.6 0.13 10.6 0.2 2.3 2 0 0 2 2 2 2 Peptidase S46 Tricorn_PDZ PF14685.1 KOO23427.1 - 0.0026 17.5 0.0 0.0061 16.3 0.0 1.6 1 0 0 1 1 1 1 Tricorn protease PDZ domain GRASP55_65 PF04495.9 KOO23427.1 - 0.0081 16.1 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain SM-ATX PF14438.1 KOO23427.1 - 0.028 14.3 0.1 0.099 12.5 0.0 2.0 2 0 0 2 2 2 0 Ataxin 2 SM domain Nucleotid_trans PF03407.11 KOO23428.1 - 1.3e-25 90.4 0.0 1.7e-25 90.0 0.0 1.1 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Pinin_SDK_memA PF04696.8 KOO23430.1 - 8e-13 48.1 2.8 8e-13 48.1 2.0 1.8 2 0 0 2 2 2 1 pinin/SDK/memA/ protein conserved region DUF963 PF06131.6 KOO23430.1 - 0.3 10.3 13.7 0.64 9.3 9.5 1.5 1 0 0 1 1 1 0 Schizosaccharomyces pombe repeat of unknown function (DUF963) Tropomyosin_1 PF12718.2 KOO23430.1 - 0.42 10.4 10.0 5.6 6.8 0.3 2.6 2 0 0 2 2 2 0 Tropomyosin like APG6 PF04111.7 KOO23430.1 - 0.5 9.3 6.7 0.97 8.4 2.3 2.1 2 0 0 2 2 2 0 Autophagy protein Apg6 Snapin_Pallidin PF14712.1 KOO23430.1 - 0.73 10.1 6.4 8.3 6.7 1.5 3.2 2 1 1 3 3 3 0 Snapin/Pallidin Snf7 PF03357.16 KOO23430.1 - 1.1 8.6 9.8 0.16 11.3 2.6 2.2 2 0 0 2 2 2 0 Snf7 Seryl_tRNA_N PF02403.17 KOO23430.1 - 1.4 8.9 11.8 7.6 6.5 0.4 3.2 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Mito_carr PF00153.22 KOO23433.1 - 5.5e-18 64.4 0.6 1.4e-10 40.7 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Arm PF00514.18 KOO23435.1 - 0.005 16.6 0.8 0.25 11.2 0.0 3.7 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat COMP PF11598.3 KOO23435.1 - 0.011 15.7 0.6 0.089 12.8 0.1 2.4 2 0 0 2 2 2 0 Cartilage oligomeric matrix protein Spc7 PF08317.6 KOO23435.1 - 0.025 13.2 10.2 0.037 12.6 7.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein AbiH PF14253.1 KOO23435.1 - 0.047 13.2 0.9 0.067 12.7 0.6 1.2 1 0 0 1 1 1 0 Bacteriophage abortive infection AbiH Spherulin4 PF12138.3 KOO23435.1 - 0.21 10.9 0.3 0.37 10.1 0.2 1.3 1 0 0 1 1 1 0 Spherulation-specific family 4 Fib_alpha PF08702.5 KOO23435.1 - 0.31 11.1 7.1 0.57 10.2 4.9 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family TMF_TATA_bd PF12325.3 KOO23435.1 - 0.32 10.7 11.3 0.48 10.1 6.9 2.0 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF848 PF05852.6 KOO23435.1 - 0.39 10.5 7.5 0.2 11.5 3.6 1.7 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) RE_Alw26IDE PF09665.5 KOO23435.1 - 0.42 9.2 2.4 0.63 8.6 1.6 1.1 1 0 0 1 1 1 0 Type II restriction endonuclease (RE_Alw26IDE) ADIP PF11559.3 KOO23435.1 - 0.44 10.4 16.7 0.15 11.9 8.4 2.4 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Atg14 PF10186.4 KOO23435.1 - 0.48 9.3 9.6 0.85 8.4 6.6 1.4 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 SlyX PF04102.7 KOO23435.1 - 0.64 10.4 12.2 5.1 7.5 1.6 3.4 2 1 1 3 3 3 0 SlyX Jnk-SapK_ap_N PF09744.4 KOO23435.1 - 0.86 9.5 12.1 4.9 7.1 3.6 3.0 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 V_ATPase_I PF01496.14 KOO23435.1 - 0.96 7.2 4.1 1.3 6.7 2.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Exonuc_VII_L PF02601.10 KOO23435.1 - 1.1 8.3 9.4 1.8 7.6 6.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit IFT57 PF10498.4 KOO23435.1 - 1.2 7.7 11.8 1.2 7.8 7.5 1.4 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 DUF3584 PF12128.3 KOO23435.1 - 2.5 5.2 16.9 3.7 4.7 11.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) APG6 PF04111.7 KOO23435.1 - 2.6 6.9 12.9 4.1 6.3 9.0 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 TMCO5 PF14992.1 KOO23435.1 - 2.8 6.9 16.3 8.3 5.4 11.3 1.6 1 1 0 1 1 1 0 TMCO5 family Macoilin PF09726.4 KOO23435.1 - 2.9 6.0 9.1 4 5.6 6.3 1.2 1 0 0 1 1 1 0 Transmembrane protein Bap31 PF05529.7 KOO23435.1 - 3.5 7.0 18.4 0.68 9.3 3.0 2.8 2 1 1 3 3 3 0 B-cell receptor-associated protein 31-like AAA_23 PF13476.1 KOO23435.1 - 7.6 6.7 8.3 14 5.9 5.8 1.3 1 0 0 1 1 1 0 AAA domain WD40 PF00400.27 KOO23436.1 - 1.2e-21 75.7 14.6 9.8e-09 34.7 0.2 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat SART-1 PF03343.8 KOO23438.1 - 0.015 13.6 13.0 0.016 13.5 9.0 1.0 1 0 0 1 1 1 0 SART-1 family DUF2058 PF09831.4 KOO23438.1 - 1.8 8.4 18.7 1.9 8.3 13.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) Rtf2 PF04641.7 KOO23438.1 - 4.3 6.4 20.3 4.6 6.3 14.1 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger BORG_CEP PF14957.1 KOO23438.1 - 6 7.8 7.1 7.3 7.5 5.0 1.1 1 0 0 1 1 1 0 Cdc42 effector Spore_coat_CotO PF14153.1 KOO23438.1 - 9.3 5.6 19.2 9.9 5.5 13.3 1.0 1 0 0 1 1 1 0 Spore coat protein CotO MAPKK1_Int PF08923.5 KOO23439.1 - 8.2e-18 64.1 0.0 9.8e-18 63.9 0.0 1.0 1 0 0 1 1 1 1 Mitogen-activated protein kinase kinase 1 interacting MCM PF00493.18 KOO23440.1 - 7.4e-127 422.7 0.0 1.8e-126 421.4 0.0 1.6 2 0 0 2 2 2 1 MCM2/3/5 family MCM_N PF14551.1 KOO23440.1 - 4.3e-21 75.6 0.3 1.2e-20 74.2 0.1 1.9 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 KOO23440.1 - 3.3e-08 32.9 0.2 2.4e-05 23.6 0.0 2.7 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 KOO23440.1 - 9.5e-08 31.8 0.0 3e-07 30.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 KOO23440.1 - 0.00037 20.0 0.1 0.0011 18.6 0.1 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.24 KOO23440.1 - 0.0037 17.4 0.8 0.4 10.8 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase_2 PF13335.1 KOO23440.1 - 0.011 16.1 0.5 0.17 12.3 0.2 2.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI SOR_SNZ PF01680.12 KOO23440.1 - 0.011 15.3 0.1 0.038 13.5 0.0 2.0 2 0 0 2 2 2 0 SOR/SNZ family DUF3356 PF11836.3 KOO23440.1 - 0.029 14.1 0.0 0.11 12.3 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3356) Sigma54_activat PF00158.21 KOO23440.1 - 0.079 12.4 0.3 0.89 9.0 0.0 2.4 3 0 0 3 3 3 0 Sigma-54 interaction domain DEAD PF00270.24 KOO23441.1 - 4.9e-42 143.2 0.0 6.7e-42 142.8 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO23441.1 - 2.8e-24 84.7 0.0 4.7e-24 84.0 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PaaSYMP PF14738.1 KOO23442.1 - 1.8e-48 164.1 6.9 1.8e-48 164.1 4.8 3.8 2 1 1 4 4 4 1 Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1 UvrD-helicase PF00580.16 KOO23442.1 - 8.9 5.5 11.1 1.8 7.8 1.7 2.3 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain EPL1 PF10513.4 KOO23443.1 - 9.7e-06 25.9 0.0 2.4e-05 24.6 0.0 1.7 1 1 0 1 1 1 1 Enhancer of polycomb-like zf-AN1 PF01428.11 KOO23444.1 - 2.4e-10 40.1 8.1 2.4e-10 40.1 5.6 1.9 2 0 0 2 2 2 1 AN1-like Zinc finger zf-A20 PF01754.11 KOO23444.1 - 4.8e-10 38.8 5.2 1.2e-09 37.6 3.6 1.7 1 0 0 1 1 1 1 A20-like zinc finger Mito_fiss_reg PF05308.6 KOO23444.1 - 0.26 10.6 3.8 0.33 10.2 2.6 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator DUF2360 PF10152.4 KOO23444.1 - 0.91 9.8 4.8 1.3 9.2 3.3 1.4 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) FAP PF07174.6 KOO23444.1 - 3.3 6.9 20.3 4.3 6.5 14.1 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) PRKCSH-like PF12999.2 KOO23445.1 - 5.2e-36 123.8 0.3 1.2e-35 122.6 0.2 1.6 1 0 0 1 1 1 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.1 KOO23445.1 - 1.2e-26 92.9 0.0 1.9e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.8 KOO23445.1 - 5.3e-05 23.9 1.3 0.00012 22.8 0.3 2.1 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein Ldl_recept_a PF00057.13 KOO23445.1 - 0.029 14.2 2.1 0.029 14.2 1.5 2.8 1 1 1 2 2 2 0 Low-density lipoprotein receptor domain class A ATG27 PF09451.5 KOO23445.1 - 0.032 13.4 0.1 0.069 12.3 0.1 1.5 1 0 0 1 1 1 0 Autophagy-related protein 27 Adaptin_N PF01602.15 KOO23446.1 - 4.8e-94 315.5 6.5 6.3e-94 315.1 4.5 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.1 KOO23446.1 - 9.2e-63 209.7 0.0 2.5e-62 208.3 0.0 1.8 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.7 KOO23446.1 - 1.5e-54 183.4 0.6 4.1e-54 182.0 0.4 1.8 1 0 0 1 1 1 1 Coatomer beta C-terminal region HEAT_2 PF13646.1 KOO23446.1 - 2.6e-09 37.2 2.7 0.00017 21.7 0.0 4.5 1 1 2 3 3 3 3 HEAT repeats Cnd1 PF12717.2 KOO23446.1 - 5.1e-06 26.4 3.0 0.031 14.1 0.2 2.9 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 KOO23446.1 - 0.0012 18.7 4.3 0.21 11.7 0.0 4.3 5 0 0 5 5 5 1 HEAT repeat ParcG PF10274.4 KOO23446.1 - 0.0081 16.0 2.8 3.7 7.4 0.3 3.4 3 1 1 4 4 4 2 Parkin co-regulated protein WD40 PF00400.27 KOO23447.1 - 5e-86 279.8 33.7 1.8e-13 49.8 0.4 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 KOO23447.1 - 1.6e-12 47.5 1.7 0.0031 17.2 0.0 4.1 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A PD40 PF07676.7 KOO23447.1 - 7.7e-12 44.5 9.2 0.75 9.5 0.0 7.5 7 1 1 8 8 8 5 WD40-like Beta Propeller Repeat DUF3312 PF11768.3 KOO23447.1 - 5.4e-08 31.5 0.0 0.042 12.0 0.0 4.0 1 1 3 4 4 4 3 Protein of unknown function (DUF3312) BBS2_Mid PF14783.1 KOO23447.1 - 8.8e-08 31.9 0.4 0.021 14.5 0.0 4.6 1 1 4 5 5 5 3 Ciliary BBSome complex subunit 2, middle region DUF1513 PF07433.6 KOO23447.1 - 4.2e-06 25.8 0.6 0.37 9.6 0.1 4.2 1 1 3 4 4 4 3 Protein of unknown function (DUF1513) RED_C PF07807.6 KOO23447.1 - 3.4e-05 24.0 0.3 6.9 6.8 0.0 4.7 1 1 3 5 5 5 2 RED-like protein C-terminal region Dfp1_Him1_M PF08630.5 KOO23447.1 - 0.00044 20.0 13.5 8.8 6.1 0.0 6.8 5 2 2 7 7 7 1 Dfp1/Him1, central region CPSF_A PF03178.10 KOO23447.1 - 0.0013 17.8 0.1 0.22 10.5 0.0 2.2 1 1 1 2 2 2 2 CPSF A subunit region Flt3_lig PF02947.9 KOO23447.1 - 0.0066 16.3 0.0 50 3.7 0.0 4.6 4 1 1 5 5 5 0 flt3 ligand rOmpB PF12334.3 KOO23447.1 - 0.018 14.4 3.9 7.7 5.8 0.0 4.7 1 1 2 4 4 4 0 Rickettsia outer membrane protein B Ham1p_like PF01725.11 KOO23447.1 - 0.059 12.7 0.0 5.2 6.3 0.0 3.3 1 1 3 4 4 4 0 Ham1 family Methyltransf_16 PF10294.4 KOO23448.1 - 2.9e-05 23.5 0.0 6.9e-05 22.3 0.0 1.6 1 1 0 1 1 1 1 Putative methyltransferase Lipase_GDSL_2 PF13472.1 KOO23448.1 - 0.12 12.5 0.1 0.13 12.3 0.1 1.3 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family PH PF00169.24 KOO23449.1 - 4.3e-09 36.5 0.0 7.1e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 PH domain Orai-1 PF07856.7 KOO23449.1 - 4.3e-05 23.1 5.0 7.5e-05 22.3 3.4 1.3 1 0 0 1 1 1 1 Mediator of CRAC channel activity PH_11 PF15413.1 KOO23449.1 - 0.0025 18.0 0.0 0.0059 16.8 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain ABC2_membrane_4 PF12730.2 KOO23449.1 - 0.41 9.7 7.7 0.59 9.2 5.3 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Bestrophin PF01062.16 KOO23452.1 - 5.8e-25 87.8 0.0 1e-24 86.9 0.0 1.4 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Mesd PF10185.4 KOO23452.1 - 1.1e-08 34.9 8.2 7.3e-07 29.0 5.7 2.3 1 1 0 1 1 1 1 Chaperone for wingless signalling and trafficking of LDL receptor Ribosomal_L38e PF01781.13 KOO23453.1 - 2.6e-33 113.5 5.6 2.9e-33 113.4 3.9 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family Glyco_trans_1_4 PF13692.1 KOO23454.1 - 5.7e-17 62.1 0.0 1.8e-16 60.5 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 KOO23454.1 - 0.00045 20.4 0.0 0.00082 19.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Gly-zipper_OmpA PF13436.1 KOO23454.1 - 2.5 7.7 11.3 0.41 10.3 5.1 1.7 2 0 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain NIF PF03031.13 KOO23455.1 - 4.4e-18 65.4 0.0 5.4e-18 65.1 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD_2 PF13419.1 KOO23455.1 - 0.0055 16.9 0.0 0.0072 16.5 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase CRAL_TRIO PF00650.15 KOO23458.1 - 1.7e-15 56.8 0.0 2.8e-15 56.1 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain EF-hand_1 PF00036.27 KOO23458.1 - 6.6e-13 46.9 0.1 3e-06 26.1 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO23458.1 - 1.6e-08 33.5 0.0 0.0067 15.7 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO23458.1 - 2.9e-08 33.7 0.0 6.6e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO23458.1 - 6.1e-08 32.1 0.3 4.3e-07 29.4 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO23458.1 - 2.4e-07 30.0 0.0 0.02 14.7 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_9 PF14658.1 KOO23458.1 - 0.00082 19.2 0.0 0.0018 18.1 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain DUF1501 PF07394.7 KOO23459.1 - 0.15 10.9 0.9 0.2 10.4 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) bZIP_2 PF07716.10 KOO23459.1 - 0.19 11.6 10.1 0.32 10.8 7.0 1.4 1 0 0 1 1 1 0 Basic region leucine zipper DUF2244 PF10003.4 KOO23459.1 - 3.3 7.0 6.8 12 5.2 0.0 2.6 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) Tex_N PF09371.5 KOO23460.1 - 0.052 12.8 0.1 0.061 12.6 0.0 1.1 1 0 0 1 1 1 0 Tex-like protein N-terminal domain SNF2_N PF00176.18 KOO23461.1 - 3.9e-77 258.9 0.1 6.1e-77 258.3 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.5 KOO23461.1 - 1.4e-37 127.9 0.5 4.3e-37 126.4 0.4 1.9 1 0 0 1 1 1 1 SLIDE Helicase_C PF00271.26 KOO23461.1 - 1.7e-15 56.6 0.0 7.2e-14 51.4 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 KOO23461.1 - 4.8e-08 32.1 0.0 9.4e-08 31.2 0.0 1.4 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Myb_DNA-binding PF00249.26 KOO23461.1 - 5.6e-08 32.7 1.8 0.0021 18.0 0.1 3.8 4 0 0 4 4 4 2 Myb-like DNA-binding domain ResIII PF04851.10 KOO23461.1 - 1.2e-07 31.7 1.4 3.9e-06 26.8 0.0 3.8 4 2 0 4 4 4 1 Type III restriction enzyme, res subunit DEAD PF00270.24 KOO23461.1 - 8.5e-06 25.3 0.0 1.9e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase HMG_box PF00505.14 KOO23461.1 - 0.0034 17.6 7.1 0.0047 17.1 3.7 2.4 1 1 0 1 1 1 1 HMG (high mobility group) box AAA_22 PF13401.1 KOO23461.1 - 0.094 12.8 0.0 0.39 10.8 0.0 2.1 1 0 0 1 1 1 0 AAA domain RRM_1 PF00076.17 KOO23462.1 - 1.1e-16 60.2 0.0 1.7e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO23462.1 - 6e-12 45.3 0.0 9.7e-12 44.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO23462.1 - 2.2e-05 24.2 0.0 4.9e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 KOO23462.1 - 0.0058 16.4 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 RNA binding motif Dimer_Tnp_hAT PF05699.9 KOO23463.1 - 0.00017 21.1 0.0 0.00027 20.5 0.0 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Spc7_N PF15402.1 KOO23464.1 - 0.5 8.3 12.7 0.67 7.8 8.8 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 PDT PF00800.13 KOO23465.1 - 5e-11 42.4 0.0 1.9e-10 40.5 0.0 1.8 2 0 0 2 2 2 1 Prephenate dehydratase ACT PF01842.20 KOO23465.1 - 6e-06 25.6 0.1 2.9e-05 23.4 0.0 2.3 2 0 0 2 2 2 1 ACT domain CM_2 PF01817.16 KOO23465.1 - 6.4e-05 22.9 0.3 0.00034 20.6 0.0 2.2 2 1 0 2 2 2 1 Chorismate mutase type II ACT_5 PF13710.1 KOO23465.1 - 0.026 14.3 0.0 0.049 13.4 0.0 1.4 1 0 0 1 1 1 0 ACT domain Pkinase PF00069.20 KOO23466.1 - 8.5e-69 231.5 0.0 1.4e-68 230.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO23466.1 - 8.3e-51 172.5 0.0 2.4e-50 171.0 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO23466.1 - 6.2e-05 22.0 0.0 0.00013 21.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Arm PF00514.18 KOO23466.1 - 0.042 13.6 3.5 15 5.6 0.0 4.7 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Kdo PF06293.9 KOO23466.1 - 0.09 11.8 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Proteasome PF00227.21 KOO23467.1 - 5.7e-57 192.0 0.1 8.7e-57 191.4 0.1 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 KOO23467.1 - 9.4e-15 53.6 0.2 1.7e-14 52.7 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Lipase_GDSL_2 PF13472.1 KOO23468.1 - 1.4e-11 44.8 0.0 1.8e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 KOO23468.1 - 2.5e-05 24.2 0.0 7.8e-05 22.6 0.0 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Adeno_PX PF05829.7 KOO23468.1 - 0.0036 16.7 0.1 0.0056 16.1 0.1 1.2 1 0 0 1 1 1 1 Adenovirus late L2 mu core protein (Protein X) Ion_trans PF00520.26 KOO23469.1 - 3.2e-17 62.4 4.8 5.3e-17 61.7 3.3 1.3 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO23469.1 - 9e-09 34.9 2.6 9e-09 34.9 1.8 2.8 4 0 0 4 4 4 1 Ion channel DUF288 PF03385.12 KOO23469.1 - 0.094 11.1 0.1 0.23 9.8 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function, DUF288 Mem_trans PF03547.13 KOO23471.1 - 2.3e-15 55.7 9.8 2.9e-15 55.4 6.8 1.1 1 0 0 1 1 1 1 Membrane transport protein EF-hand_7 PF13499.1 KOO23472.1 - 1.7e-19 69.7 3.0 5.9e-08 32.7 0.0 4.0 3 2 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO23472.1 - 7.2e-19 65.6 12.3 6.9e-07 28.1 0.1 5.6 5 1 0 5 5 5 4 EF hand EF-hand_6 PF13405.1 KOO23472.1 - 2.2e-18 64.4 9.7 8e-06 25.3 0.1 5.5 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.1 KOO23472.1 - 4.7e-12 44.6 8.8 0.00013 21.1 0.2 4.4 4 1 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO23472.1 - 2.1e-10 40.0 5.9 0.00025 20.5 0.2 5.0 5 0 0 5 5 5 2 EF-hand domain pair TCR PF03638.10 KOO23473.1 - 4.2e-22 77.7 53.1 1.4e-12 47.2 16.4 2.4 3 0 0 3 3 3 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain Methyltransf_24 PF13578.1 KOO23475.1 - 0.0024 18.6 0.0 0.0081 16.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Pyr_redox_2 PF07992.9 KOO23476.1 - 7.9e-05 22.6 0.0 0.0031 17.4 0.0 3.0 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOO23476.1 - 0.00084 19.6 0.0 0.004 17.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 KOO23476.1 - 0.0015 17.0 0.1 0.0027 16.2 0.1 1.4 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.1 KOO23476.1 - 0.0027 17.7 0.0 0.0061 16.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOO23476.1 - 0.0027 16.6 1.3 0.011 14.7 0.1 2.3 1 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 KOO23476.1 - 0.038 12.8 2.5 0.058 12.2 0.1 2.4 3 0 0 3 3 3 0 FAD binding domain FAD_binding_3 PF01494.14 KOO23476.1 - 0.039 12.9 2.2 0.25 10.3 0.2 2.8 2 1 0 2 2 2 0 FAD binding domain LSM PF01423.17 KOO23477.1 - 4.2e-14 51.8 0.0 7e-14 51.1 0.0 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 KOO23477.1 - 0.012 15.4 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 Ataxin 2 SM domain Erythro-docking PF09277.6 KOO23477.1 - 0.062 13.0 0.1 0.15 11.7 0.1 1.6 1 0 0 1 1 1 0 Erythronolide synthase, docking PTCB-BRCT PF12738.2 KOO23478.1 - 0.00039 20.2 0.0 0.00064 19.5 0.0 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.21 KOO23478.1 - 0.046 13.8 0.0 0.079 13.1 0.0 1.4 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Trypsin_2 PF13365.1 KOO23479.1 - 7.9e-22 77.4 0.7 1.3e-21 76.8 0.5 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.21 KOO23479.1 - 1.2e-18 67.5 0.1 1.8e-18 66.9 0.1 1.3 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.1 KOO23479.1 - 1.3e-13 50.5 0.1 4e-12 45.8 0.0 2.7 3 0 0 3 3 3 1 PDZ domain Peptidase_S46 PF10459.4 KOO23479.1 - 3.9e-06 25.6 0.7 0.0077 14.7 0.1 2.1 2 0 0 2 2 2 2 Peptidase S46 LSM PF01423.17 KOO23479.1 - 0.002 17.6 0.0 0.004 16.6 0.0 1.4 1 0 0 1 1 1 1 LSM domain HAS-barrel PF09378.5 KOO23479.1 - 0.0034 17.2 0.1 0.0099 15.7 0.0 1.9 2 0 0 2 2 2 1 HAS barrel domain PDZ PF00595.19 KOO23479.1 - 0.0041 17.2 0.1 0.34 11.1 0.0 2.7 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) Peptidase_S32 PF05579.8 KOO23479.1 - 0.012 14.5 1.3 0.57 9.1 0.0 2.2 1 1 1 2 2 2 0 Equine arteritis virus serine endopeptidase S32 Peptidase_S29 PF02907.10 KOO23479.1 - 0.13 11.8 0.0 0.26 10.7 0.0 1.5 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Exostosin PF03016.10 KOO23480.1 - 5.8e-13 48.5 0.0 7.5e-13 48.1 0.0 1.1 1 0 0 1 1 1 1 Exostosin family EF-hand_1 PF00036.27 KOO23481.1 - 0.00015 20.8 0.0 0.00043 19.3 0.0 1.9 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO23481.1 - 0.0012 18.5 0.0 0.0045 16.7 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 KOO23481.1 - 0.0023 18.0 0.0 0.006 16.7 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO23481.1 - 0.017 14.7 0.0 0.11 12.0 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.1 KOO23481.1 - 0.031 13.6 0.0 0.077 12.3 0.0 1.7 1 0 0 1 1 1 0 EF hand NIF3 PF01784.13 KOO23482.1 - 1.5e-34 119.6 0.0 1.8e-34 119.3 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) Bax1-I PF01027.15 KOO23483.1 - 1.4e-35 122.7 38.7 1.4e-35 122.7 26.8 1.9 2 0 0 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 NAD_binding_2 PF03446.10 KOO23484.1 - 2.5e-34 118.4 1.2 4e-34 117.8 0.8 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 KOO23484.1 - 1.6e-22 79.8 0.0 4.3e-22 78.4 0.0 1.8 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.12 KOO23484.1 - 1.2e-05 25.6 0.2 2.9e-05 24.4 0.2 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.14 KOO23484.1 - 4.7e-05 22.6 0.0 7.7e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 KOO23484.1 - 0.00022 20.9 0.6 0.00037 20.2 0.4 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.7 KOO23484.1 - 0.0017 17.7 0.1 0.0031 16.9 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain UDPG_MGDP_dh_C PF03720.10 KOO23484.1 - 0.007 16.5 0.0 0.013 15.6 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain OCD_Mu_crystall PF02423.10 KOO23484.1 - 0.036 12.8 0.2 0.052 12.3 0.1 1.2 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family Thymidylat_synt PF00303.14 KOO23485.1 - 3.5e-10 39.3 0.0 4.5e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 Thymidylate synthase Exostosin PF03016.10 KOO23486.1 - 3.1e-12 46.1 0.0 3.5e-12 45.9 0.0 1.0 1 0 0 1 1 1 1 Exostosin family TCP PF03634.8 KOO23487.1 - 0.075 13.4 1.0 0.11 12.8 0.7 1.3 1 0 0 1 1 1 0 TCP family transcription factor Redoxin PF08534.5 KOO23488.1 - 3.3e-21 75.3 0.0 5.2e-21 74.7 0.0 1.3 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 KOO23488.1 - 3.5e-05 23.4 0.0 5e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family PARG_cat PF05028.9 KOO23489.1 - 1.7e-39 136.0 0.0 3.7e-39 134.9 0.0 1.4 1 1 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) PspC PF04024.7 KOO23489.1 - 0.85 9.1 3.3 0.93 9.0 0.0 2.2 2 0 0 2 2 2 0 PspC domain Fcf2 PF08698.6 KOO23490.1 - 6.8e-27 93.3 0.0 1.1e-26 92.7 0.0 1.2 1 0 0 1 1 1 1 Fcf2 pre-rRNA processing FAM75 PF14650.1 KOO23490.1 - 0.021 14.2 0.1 0.028 13.8 0.0 1.1 1 0 0 1 1 1 0 FAM75 family DUF1523 PF07509.6 KOO23490.1 - 0.06 12.5 0.0 0.073 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1523) Peptidase_M24 PF00557.19 KOO23491.1 - 2.5e-45 154.6 0.0 4.8e-45 153.6 0.0 1.5 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 KOO23491.1 - 3e-28 97.8 0.0 6.3e-28 96.8 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain FAD_binding_3 PF01494.14 KOO23491.1 - 1.1e-08 34.6 0.0 1.4e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain SE PF08491.5 KOO23491.1 - 0.0033 16.2 0.0 0.0084 14.9 0.0 1.6 2 0 0 2 2 2 1 Squalene epoxidase Peptidase_S49_N PF08496.5 KOO23492.1 - 0.08 12.7 3.8 0.091 12.5 2.7 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal APG6 PF04111.7 KOO23492.1 - 0.094 11.7 5.9 0.11 11.5 4.1 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 ADIP PF11559.3 KOO23492.1 - 0.26 11.2 7.5 0.34 10.7 5.2 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DivIC PF04977.10 KOO23492.1 - 0.32 10.5 11.5 0.68 9.4 0.0 2.3 2 1 0 2 2 2 0 Septum formation initiator Herpes_BLRF2 PF05812.7 KOO23492.1 - 0.33 10.7 9.7 0.48 10.2 0.9 2.2 1 1 1 2 2 2 0 Herpesvirus BLRF2 protein Spc7 PF08317.6 KOO23492.1 - 1 7.9 7.7 1.3 7.6 5.3 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein SlyX PF04102.7 KOO23492.1 - 1.8 8.9 5.8 11 6.4 2.0 2.2 1 1 1 2 2 2 0 SlyX Atg14 PF10186.4 KOO23492.1 - 4 6.2 7.4 5 5.9 5.2 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Viral_P18 PF04521.8 KOO23492.1 - 4.7 6.6 10.2 1.6 8.1 0.3 2.1 1 1 1 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein DUF4140 PF13600.1 KOO23492.1 - 9.8 6.6 9.7 20 5.6 2.6 2.3 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Dynein_heavy PF03028.10 KOO23494.1 - 3.3e-188 627.0 0.0 5.6e-188 626.2 0.0 1.3 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor AAA_8 PF12780.2 KOO23494.1 - 8.5e-107 356.0 0.0 1.6e-106 355.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 DHC_N2 PF08393.8 KOO23494.1 - 2.2e-102 342.6 1.2 2.2e-102 342.6 0.8 2.9 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 KOO23494.1 - 3.3e-87 291.8 0.0 7.1e-87 290.7 0.0 1.6 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_9 PF12781.2 KOO23494.1 - 2.9e-83 278.1 0.2 5.8e-83 277.1 0.2 1.5 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_7 PF12775.2 KOO23494.1 - 3.5e-81 272.2 0.1 9.8e-81 270.8 0.1 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 MT PF12777.2 KOO23494.1 - 5.5e-59 199.6 13.0 1e-58 198.7 9.0 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Kelch_3 PF13415.1 KOO23494.1 - 3.4e-31 106.6 20.6 1.2e-07 31.6 0.0 8.7 8 0 0 8 8 8 6 Galactose oxidase, central domain Kelch_4 PF13418.1 KOO23494.1 - 6.9e-26 89.7 16.2 2e-07 30.6 0.0 7.5 8 0 0 8 8 6 6 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO23494.1 - 1.7e-20 72.5 1.5 0.0042 17.0 0.0 7.8 7 0 0 7 7 7 4 Kelch motif AAA_5 PF07728.9 KOO23494.1 - 1.2e-17 63.9 0.1 1.2e-07 31.5 0.0 5.2 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) Kelch_1 PF01344.20 KOO23494.1 - 1.9e-13 49.7 9.1 0.0022 17.4 0.6 5.7 5 0 0 5 5 5 4 Kelch motif Filamin PF00630.14 KOO23494.1 - 5.2e-13 49.4 0.0 1.2e-12 48.2 0.0 1.6 1 0 0 1 1 1 1 Filamin/ABP280 repeat Kelch_6 PF13964.1 KOO23494.1 - 9.3e-13 47.7 7.5 0.059 13.5 0.1 6.8 7 0 0 7 7 6 3 Kelch motif Kelch_2 PF07646.10 KOO23494.1 - 2.9e-10 39.4 13.3 0.22 11.3 0.1 7.6 7 0 0 7 7 7 3 Kelch motif TIG PF01833.19 KOO23494.1 - 3.3e-08 33.4 0.1 8.4e-08 32.1 0.1 1.7 1 0 0 1 1 1 1 IPT/TIG domain AAA_16 PF13191.1 KOO23494.1 - 0.00023 21.2 1.4 0.52 10.2 0.0 4.5 4 0 0 4 4 3 1 AAA ATPase domain AAA_22 PF13401.1 KOO23494.1 - 0.0013 18.9 0.0 9.3 6.4 0.0 4.5 4 0 0 4 4 4 0 AAA domain AAA PF00004.24 KOO23494.1 - 0.028 14.5 0.1 5.8 7.1 0.0 2.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Pox_A32 PF04665.7 KOO23494.1 - 0.15 11.3 0.1 0.29 10.4 0.0 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein Viral_helicase1 PF01443.13 KOO23494.1 - 0.6 9.5 0.2 30 4.0 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase WTX PF09422.5 KOO23494.1 - 4.1 6.2 0.4 6.6 5.5 0.3 1.2 1 0 0 1 1 1 0 WTX protein Glyco_tran_28_C PF04101.11 KOO23495.1 - 1.8e-11 43.9 0.0 8.9e-09 35.2 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase family 28 C-terminal domain O-FucT PF10250.4 KOO23496.1 - 1.7e-14 53.7 0.0 5.3e-10 38.9 0.0 2.6 2 1 0 2 2 2 2 GDP-fucose protein O-fucosyltransferase TPR_11 PF13414.1 KOO23496.1 - 2.8e-11 42.8 8.8 1.7e-07 30.7 1.2 3.4 2 1 1 3 3 3 2 TPR repeat TPR_2 PF07719.12 KOO23496.1 - 1.7e-09 36.8 15.9 0.00089 19.0 0.1 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO23496.1 - 1.4e-06 27.6 3.8 0.19 11.6 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO23496.1 - 2.3e-06 28.0 34.4 4.2e-06 27.2 5.5 4.5 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOO23496.1 - 4.8e-06 26.4 15.1 0.00018 21.3 1.9 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO23496.1 - 1.1e-05 25.6 29.1 0.067 13.8 0.6 5.6 3 1 2 5 5 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO23496.1 - 1.5e-05 24.3 2.1 2 8.1 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO23496.1 - 3.7e-05 23.9 7.2 0.0017 18.6 0.3 3.6 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO23496.1 - 0.0098 16.0 0.4 5.6 7.4 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO23496.1 - 0.021 14.5 0.0 6.3 6.8 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat NARP1 PF12569.3 KOO23496.1 - 0.34 9.6 0.1 0.49 9.0 0.1 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TPR_6 PF13174.1 KOO23496.1 - 0.53 10.8 3.2 38 5.0 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.1 KOO23496.1 - 1.2 9.1 16.1 3.1 7.8 1.6 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat PCI_Csn8 PF10075.4 KOO23497.1 - 2.1e-29 102.1 1.9 4.8e-28 97.7 1.3 2.2 1 1 0 1 1 1 1 COP9 signalosome, subunit CSN8 SAC3_GANP PF03399.11 KOO23497.1 - 7.5e-24 84.4 4.3 8.9e-23 80.9 2.5 2.4 2 1 0 2 2 2 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PPR_2 PF13041.1 KOO23499.1 - 1.1e-60 201.4 0.0 3.3e-09 36.5 0.0 14.1 8 4 7 15 15 15 10 PPR repeat family PPR_3 PF13812.1 KOO23499.1 - 1.2e-50 165.5 48.0 6.3e-06 26.0 0.0 18.3 18 2 1 19 19 19 10 Pentatricopeptide repeat domain PPR PF01535.15 KOO23499.1 - 3.4e-45 148.8 17.8 2.3e-05 24.0 0.0 17.4 20 0 0 20 20 20 8 PPR repeat PPR_1 PF12854.2 KOO23499.1 - 5.4e-29 99.3 0.0 8e-06 25.2 0.0 12.4 14 0 0 14 14 14 7 PPR repeat TPR_7 PF13176.1 KOO23499.1 - 8.8e-09 34.5 18.3 0.92 9.4 0.0 11.4 13 0 0 13 13 13 2 Tetratricopeptide repeat Clathrin PF00637.15 KOO23499.1 - 0.0047 16.5 0.0 36 3.9 0.0 5.3 7 0 0 7 7 7 0 Region in Clathrin and VPS TPR_6 PF13174.1 KOO23499.1 - 0.13 12.7 26.8 2.4 8.7 0.5 10.2 11 0 0 11 11 11 0 Tetratricopeptide repeat Baculo_IE-1 PF05290.6 KOO23499.1 - 0.21 11.3 0.1 0.4 10.4 0.0 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) TPR_10 PF13374.1 KOO23499.1 - 2 8.4 24.2 14 5.8 0.3 7.5 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_19 PF14559.1 KOO23499.1 - 7.9 6.9 36.1 0.23 11.8 0.3 7.5 8 0 0 8 8 8 0 Tetratricopeptide repeat SET PF00856.23 KOO23500.1 - 4.7e-07 30.2 0.0 8.6e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 SET domain RE_TaqI PF09573.5 KOO23501.1 - 0.043 12.9 0.0 0.048 12.7 0.0 1.1 1 0 0 1 1 1 0 TaqI restriction endonuclease PLU-1 PF08429.6 KOO23501.1 - 0.076 11.8 0.0 0.083 11.7 0.0 1.0 1 0 0 1 1 1 0 PLU-1-like protein Rad51 PF08423.6 KOO23502.1 - 2.5e-129 429.6 0.3 3.2e-129 429.2 0.2 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 KOO23502.1 - 9.1e-12 44.7 0.0 1.3e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.16 KOO23502.1 - 1.2e-09 37.7 0.1 1.6e-09 37.2 0.1 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.1 KOO23502.1 - 8e-09 35.5 0.6 2e-08 34.3 0.4 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain KaiC PF06745.8 KOO23502.1 - 4.2e-08 32.5 0.0 7e-08 31.8 0.0 1.4 1 0 0 1 1 1 1 KaiC RNA_pol_A_CTD PF03118.10 KOO23502.1 - 0.038 13.4 0.1 0.086 12.2 0.1 1.5 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain SpoOE-like PF09388.5 KOO23502.1 - 0.061 12.8 0.1 4.1 7.0 0.0 2.7 3 0 0 3 3 3 0 Spo0E like sporulation regulatory protein ABC_membrane PF00664.18 KOO23503.1 - 4.8e-59 200.0 19.4 4e-31 108.4 1.1 3.3 3 1 1 4 4 3 2 ABC transporter transmembrane region ABC_tran PF00005.22 KOO23503.1 - 2.9e-46 157.1 0.0 2.8e-26 92.4 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 KOO23503.1 - 3.5e-10 39.4 0.1 0.029 13.5 0.0 4.1 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 KOO23503.1 - 1.6e-08 34.8 0.1 0.52 10.2 0.0 4.5 4 1 0 5 5 4 2 AAA domain AAA_16 PF13191.1 KOO23503.1 - 9e-08 32.3 2.7 0.0024 17.8 0.1 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.1 KOO23503.1 - 1.8e-06 28.4 0.1 0.027 14.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.1 KOO23503.1 - 0.00016 21.1 1.3 0.14 11.6 0.3 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.18 KOO23503.1 - 0.00029 20.7 0.1 0.73 9.8 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase NB-ARC PF00931.17 KOO23503.1 - 0.0009 18.1 0.0 1.8 7.3 0.0 2.9 3 1 0 3 3 3 2 NB-ARC domain AAA_17 PF13207.1 KOO23503.1 - 0.00091 20.0 0.2 0.28 12.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 KOO23503.1 - 0.0015 18.6 1.6 1.5 8.9 0.1 3.7 2 2 0 2 2 2 1 AAA domain AAA_25 PF13481.1 KOO23503.1 - 0.002 17.5 4.0 0.068 12.5 1.2 2.7 2 1 0 2 2 2 1 AAA domain SbcCD_C PF13558.1 KOO23503.1 - 0.0022 17.8 1.1 7.3 6.5 0.0 4.7 3 1 0 3 3 3 0 Putative exonuclease SbcCD, C subunit DUF258 PF03193.11 KOO23503.1 - 0.0027 16.9 0.2 0.53 9.4 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_30 PF13604.1 KOO23503.1 - 0.0099 15.4 0.9 14 5.2 0.0 3.8 4 0 0 4 4 4 0 AAA domain AAA_18 PF13238.1 KOO23503.1 - 0.011 16.0 0.3 1.5 9.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 KOO23503.1 - 0.012 14.7 0.3 3.7 6.5 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin T2SE PF00437.15 KOO23503.1 - 0.015 14.1 0.2 0.88 8.4 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein ArgK PF03308.11 KOO23503.1 - 0.017 13.9 0.8 0.96 8.1 0.1 2.2 2 0 0 2 2 2 0 ArgK protein Miro PF08477.8 KOO23503.1 - 0.021 15.3 0.3 9 6.8 0.0 2.5 2 0 0 2 2 2 0 Miro-like protein ATP-synt_ab PF00006.20 KOO23503.1 - 0.025 14.0 0.0 1.5 8.2 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain cobW PF02492.14 KOO23503.1 - 0.043 13.2 1.8 0.48 9.8 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TrwB_AAD_bind PF10412.4 KOO23503.1 - 0.052 12.1 1.2 1.2 7.7 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Dynamin_N PF00350.18 KOO23503.1 - 0.058 13.2 0.3 6.3 6.5 0.0 2.4 2 0 0 2 2 2 0 Dynamin family AAA_10 PF12846.2 KOO23503.1 - 0.25 10.7 0.8 5 6.4 0.2 2.4 2 0 0 2 2 2 0 AAA-like domain DUF87 PF01935.12 KOO23503.1 - 0.56 9.9 1.7 1.4 8.6 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF87 AAA_15 PF13175.1 KOO23503.1 - 0.89 8.5 1.1 2.3 7.1 0.0 2.0 3 0 0 3 3 2 0 AAA ATPase domain UMPH-1 PF05822.7 KOO23504.1 - 2.3e-34 118.8 0.0 3.1e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD PF12710.2 KOO23504.1 - 2.2e-11 44.2 0.0 3.6e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 KOO23504.1 - 6e-05 23.3 0.0 0.00043 20.5 0.0 2.3 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOO23504.1 - 0.002 18.5 0.0 0.0079 16.6 0.0 1.7 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.7 KOO23504.1 - 0.005 16.0 0.0 0.56 9.3 0.0 2.7 2 1 0 2 2 2 1 Putative Phosphatase Ion_trans PF00520.26 KOO23505.1 - 4.6e-175 577.7 63.7 1.7e-47 161.2 7.0 4.6 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 KOO23505.1 - 9.2e-20 70.4 60.8 1.8e-11 43.1 0.1 9.8 8 2 1 10 10 10 8 Polycystin cation channel Ninjurin PF04923.7 KOO23505.1 - 0.045 13.4 8.4 1.1 9.0 0.1 4.2 3 0 0 3 3 3 0 Ninjurin DUF1542 PF07564.6 KOO23505.1 - 0.43 10.6 0.6 1 9.4 0.4 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) ATP-synt_A PF00119.15 KOO23506.1 - 0.00037 20.0 0.4 0.00038 20.0 0.3 1.1 1 0 0 1 1 1 1 ATP synthase A chain ADK PF00406.17 KOO23507.1 - 1.4e-43 148.3 0.0 1.9e-43 147.9 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_18 PF13238.1 KOO23507.1 - 8e-09 35.8 0.0 1.3e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 KOO23507.1 - 1.1e-07 31.8 0.0 1.9e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO23507.1 - 6.7e-05 23.6 0.0 0.00014 22.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.12 KOO23507.1 - 0.0015 17.8 0.0 0.26 10.6 0.0 2.3 2 0 0 2 2 2 2 Thymidylate kinase AAA_19 PF13245.1 KOO23507.1 - 0.036 13.7 2.7 0.51 10.1 0.1 2.9 3 0 0 3 3 3 0 Part of AAA domain Zeta_toxin PF06414.7 KOO23507.1 - 0.056 12.5 0.1 0.11 11.6 0.0 1.6 1 1 0 1 1 1 0 Zeta toxin GNT-I PF03071.10 KOO23508.1 - 2.1e-104 349.5 0.0 2.9e-104 349.0 0.0 1.1 1 0 0 1 1 1 1 GNT-I family Glycos_transf_2 PF00535.21 KOO23508.1 - 0.0019 17.9 0.0 0.003 17.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 KOO23508.1 - 0.003 17.3 0.0 0.0074 16.1 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 2OG-FeII_Oxy_3 PF13640.1 KOO23509.1 - 3.3e-10 40.3 1.0 4.2e-10 40.0 0.1 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO23509.1 - 1.6e-07 31.5 0.0 3.6e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily NAD_binding_10 PF13460.1 KOO23510.1 - 2.3e-27 96.2 0.0 3.1e-27 95.7 0.0 1.1 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 KOO23510.1 - 0.00016 20.4 0.0 0.00023 19.9 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.8 KOO23510.1 - 0.0005 19.3 0.4 0.011 15.0 0.3 2.6 1 1 0 1 1 1 1 NmrA-like family Semialdhyde_dh PF01118.19 KOO23510.1 - 0.0022 18.3 0.1 0.0034 17.6 0.1 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.15 KOO23510.1 - 0.034 14.0 0.1 0.064 13.1 0.1 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus GFO_IDH_MocA PF01408.17 KOO23510.1 - 0.049 14.1 0.2 0.088 13.3 0.1 1.4 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold adh_short PF00106.20 KOO23510.1 - 0.14 12.0 1.7 0.22 11.4 0.8 1.5 2 0 0 2 2 2 0 short chain dehydrogenase UBA PF00627.26 KOO23511.1 - 1.1e-07 31.4 0.4 2.4e-07 30.3 0.3 1.6 1 0 0 1 1 1 1 UBA/TS-N domain zf-RING_2 PF13639.1 KOO23511.1 - 6.6e-05 22.6 3.7 0.0002 21.0 2.6 1.8 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.1 KOO23511.1 - 0.0031 17.1 1.4 0.007 16.0 1.0 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) UIM PF02809.15 KOO23511.1 - 0.0031 16.9 1.7 0.014 14.9 1.2 2.2 1 0 0 1 1 1 1 Ubiquitin interaction motif CUE PF02845.11 KOO23511.1 - 0.012 15.1 0.1 0.021 14.3 0.0 1.4 1 0 0 1 1 1 0 CUE domain zf-RING_5 PF14634.1 KOO23511.1 - 0.044 13.5 2.5 0.11 12.2 1.7 1.7 1 1 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 KOO23511.1 - 0.088 12.8 2.9 0.31 11.0 2.1 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO23511.1 - 0.58 9.8 3.1 0.34 10.6 0.6 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Asp PF00026.18 KOO23512.1 - 5.5e-25 88.2 0.0 1.4e-24 86.9 0.0 1.6 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 KOO23512.1 - 0.001 19.0 0.5 0.0037 17.2 0.0 2.1 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal zinc_ribbon_2 PF13240.1 KOO23512.1 - 0.059 12.8 0.1 0.14 11.6 0.1 1.7 1 0 0 1 1 1 0 zinc-ribbon domain EF-hand_1 PF00036.27 KOO23513.1 - 5.4e-34 112.9 0.9 0.00012 21.0 0.0 6.2 6 0 0 6 6 6 6 EF hand EF-hand_5 PF13202.1 KOO23513.1 - 4.7e-33 111.0 3.6 3.4e-05 22.9 0.0 6.2 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.1 KOO23513.1 - 8.2e-31 103.0 1.4 0.0015 18.2 0.0 6.4 6 0 0 6 6 6 6 EF-hand domain EF-hand_7 PF13499.1 KOO23513.1 - 1.8e-28 98.4 0.1 1.6e-08 34.5 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO23513.1 - 6.2e-20 70.5 10.3 0.0063 16.1 0.0 6.5 4 3 3 7 7 7 6 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO23513.1 - 1.2e-09 38.2 0.0 0.029 14.4 0.0 3.7 3 1 0 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region Toprim PF01751.17 KOO23513.1 - 2.3e-05 24.2 0.2 0.83 9.6 0.0 3.2 1 1 1 2 2 2 2 Toprim domain TPR_20 PF14561.1 KOO23513.1 - 0.0032 17.5 2.2 0.52 10.4 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat EF-hand_9 PF14658.1 KOO23513.1 - 0.015 15.2 0.4 1.8 8.5 0.0 3.5 4 1 0 4 4 4 0 EF-hand domain Caleosin PF05042.8 KOO23513.1 - 0.089 12.3 0.1 5.1 6.6 0.0 3.3 3 2 1 4 4 4 0 Caleosin related protein Dockerin_1 PF00404.13 KOO23513.1 - 7 6.5 16.6 12 5.8 0.3 4.6 4 0 0 4 4 4 0 Dockerin type I repeat Ribosomal_L1 PF00687.16 KOO23514.1 - 4.2e-36 124.3 0.0 5.2e-36 124.0 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Tom22 PF04281.8 KOO23515.1 - 0.00061 19.3 0.0 0.00067 19.1 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 Cortex-I_coil PF09304.5 KOO23519.1 - 0.17 11.9 2.7 0.34 10.9 1.9 1.4 1 0 0 1 1 1 0 Cortexillin I, coiled coil TPR_19 PF14559.1 KOO23520.1 - 8.8 6.7 8.4 4.8 7.5 2.0 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat Polysacc_synt_C PF14667.1 KOO23521.1 - 2.8e-08 33.6 6.7 2.8e-08 33.6 4.6 3.6 3 1 0 3 3 3 1 Polysaccharide biosynthesis C-terminal domain MatE PF01554.13 KOO23521.1 - 0.0034 17.0 26.2 0.0064 16.1 7.0 3.5 2 2 0 2 2 2 2 MatE Pkinase PF00069.20 KOO23522.1 - 7e-50 169.5 0.0 8.1e-50 169.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO23522.1 - 3.3e-20 72.2 0.0 4.1e-20 71.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO23522.1 - 1.7e-08 34.5 0.5 0.0014 18.3 0.0 2.7 1 1 2 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO23522.1 - 2.6e-05 23.3 0.0 7.1e-05 21.9 0.0 1.7 1 1 0 2 2 2 1 Kinase-like Kdo PF06293.9 KOO23522.1 - 0.0092 15.0 0.0 0.016 14.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 KOO23522.1 - 0.015 14.6 0.0 0.027 13.8 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Choline_kinase PF01633.15 KOO23522.1 - 0.034 13.7 0.0 0.062 12.8 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase RNA_pol_Rpb6 PF01192.17 KOO23524.1 - 2.8e-22 78.2 0.3 6.8e-22 76.9 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb6 HSP20 PF00011.16 KOO23524.1 - 2.5e-08 33.6 0.0 6.4e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 Hsp20/alpha crystallin family MMR_HSR1 PF01926.18 KOO23524.1 - 0.00021 21.2 0.1 0.0036 17.2 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase GBP PF02263.14 KOO23524.1 - 0.00046 19.3 4.0 0.005 15.9 0.1 2.2 1 1 1 2 2 2 2 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.18 KOO23524.1 - 0.009 15.8 1.7 0.098 12.4 0.1 2.9 2 1 0 3 3 3 1 Dynamin family FeoB_N PF02421.13 KOO23524.1 - 0.089 12.0 0.1 0.18 11.0 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B Ras PF00071.17 KOO23525.1 - 2.3e-50 170.1 0.0 2.8e-50 169.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO23525.1 - 3.5e-16 59.7 0.0 7.5e-16 58.7 0.0 1.5 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 KOO23525.1 - 4.6e-11 42.2 0.0 6.2e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KOO23525.1 - 1.3e-05 24.4 0.0 1.6e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RNA_helicase PF00910.17 KOO23525.1 - 0.00014 22.0 0.2 0.0011 19.1 0.2 2.1 1 1 0 1 1 1 1 RNA helicase MMR_HSR1 PF01926.18 KOO23525.1 - 0.003 17.4 0.0 0.006 16.5 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.15 KOO23525.1 - 0.0044 15.7 1.3 2.2 6.9 0.0 2.7 2 1 1 3 3 3 2 G-protein alpha subunit GTP_EFTU PF00009.22 KOO23525.1 - 0.008 15.6 0.4 0.094 12.1 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.12 KOO23525.1 - 0.043 13.3 0.3 8.2 5.8 0.1 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Pox_A32 PF04665.7 KOO23525.1 - 0.052 12.8 0.1 0.082 12.1 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_22 PF13401.1 KOO23525.1 - 0.081 13.0 0.3 0.29 11.2 0.2 2.0 1 1 0 1 1 1 0 AAA domain Gelsolin PF00626.17 KOO23526.1 - 1.7e-14 53.2 0.0 0.0042 16.7 0.0 6.3 6 0 0 6 6 6 4 Gelsolin repeat cNMP_binding PF00027.24 KOO23526.1 - 1.3e-05 24.8 0.0 9.2e-05 22.1 0.0 2.4 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain PH PF00169.24 KOO23526.1 - 8.1e-05 22.7 0.0 0.0087 16.2 0.0 2.6 2 0 0 2 2 2 1 PH domain DUF3584 PF12128.3 KOO23526.1 - 2.8 5.1 17.2 3.8 4.7 11.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) MAT1 PF06391.8 KOO23526.1 - 4 6.9 9.0 6.1 6.3 6.2 1.2 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 ILVD_EDD PF00920.16 KOO23527.1 - 1.5e-200 667.0 1.8 1.7e-200 666.8 1.3 1.0 1 0 0 1 1 1 1 Dehydratase family TrkA_N PF02254.13 KOO23527.1 - 0.052 13.5 0.0 0.15 12.1 0.1 1.7 2 0 0 2 2 2 0 TrkA-N domain Peptidase_C2 PF00648.16 KOO23528.1 - 9.9e-56 188.9 0.0 1.5e-55 188.3 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease RCC1 PF00415.13 KOO23528.1 - 3.3e-33 113.6 7.3 7.8e-12 45.2 0.1 6.9 6 1 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO23528.1 - 5e-14 51.4 19.4 0.0017 17.9 0.2 6.4 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat Calpain_III PF01067.17 KOO23528.1 - 0.033 13.8 0.0 0.067 12.8 0.0 1.4 1 0 0 1 1 1 0 Calpain large subunit, domain III IQ PF00612.22 KOO23529.1 - 0.02 14.4 5.6 0.48 10.2 0.1 2.5 2 0 0 2 2 2 0 IQ calmodulin-binding motif DUF3886 PF13025.1 KOO23529.1 - 2.2 8.2 8.0 1.6 8.7 4.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3886) Exo_endo_phos PF03372.18 KOO23530.1 - 5.9e-19 68.9 0.0 7.2e-19 68.6 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family STT3 PF02516.9 KOO23531.1 - 6.7e-56 190.2 21.2 1e-51 176.4 12.2 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit PMT PF02366.13 KOO23531.1 - 0.0038 16.6 7.5 0.0084 15.4 5.2 1.5 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase HCV_env PF01539.12 KOO23531.1 - 0.044 13.2 1.8 0.1 12.0 1.3 1.5 1 0 0 1 1 1 0 Hepatitis C virus envelope glycoprotein E1 zf-CCCH PF00642.19 KOO23532.1 - 7.1e-17 60.6 23.6 4.5e-06 26.1 0.7 4.4 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) EF-hand_5 PF13202.1 KOO23533.1 - 5.7e-142 455.3 139.1 6.8e-06 25.1 0.0 28.1 13 13 15 28 28 28 28 EF hand EF-hand_1 PF00036.27 KOO23533.1 - 1.2e-121 387.0 136.0 5.2e-06 25.3 0.2 28.1 10 10 18 28 28 28 28 EF hand EF-hand_6 PF13405.1 KOO23533.1 - 2.2e-111 353.9 137.2 4.2e-05 23.0 0.3 28.1 9 9 19 28 28 28 28 EF-hand domain EF-hand_7 PF13499.1 KOO23533.1 - 5.4e-94 308.3 106.8 6.7e-09 35.7 1.5 23.2 1 1 15 16 16 16 16 EF-hand domain pair EF-hand_8 PF13833.1 KOO23533.1 - 3.7e-70 231.3 123.2 0.0013 18.2 0.3 28.0 14 10 14 28 28 28 26 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO23533.1 - 4.4e-13 49.2 33.7 0.79 9.7 0.1 19.4 3 3 11 14 14 14 1 Secreted protein acidic and rich in cysteine Ca binding region SHOCT PF09851.4 KOO23533.1 - 2.9e-08 32.8 24.3 3.5 7.2 0.1 14.3 19 0 0 19 19 19 2 Short C-terminal domain EF-hand_4 PF12763.2 KOO23533.1 - 0.00027 20.6 39.3 0.14 11.8 0.2 12.2 3 3 13 17 17 17 2 Cytoskeletal-regulatory complex EF hand PMBR PF09373.5 KOO23533.1 - 0.0014 18.5 2.8 1.5e+02 2.5 0.0 9.0 13 0 0 13 13 13 0 Pseudomurein-binding repeat DUF2782 PF11191.3 KOO23533.1 - 0.012 15.6 0.1 1.8e+02 2.1 0.0 6.5 8 1 2 10 10 10 0 Protein of unknown function (DUF2782) Phage_XkdX PF09693.5 KOO23533.1 - 0.026 14.0 8.9 55 3.3 0.0 8.2 11 0 0 11 11 11 0 Phage uncharacterised protein (Phage_XkdX) Fve PF09259.6 KOO23533.1 - 0.048 13.5 4.6 45 4.0 0.0 5.3 7 0 0 7 7 6 0 Fungal immunomodulatory protein Fve 2OG-FeII_Oxy_3 PF13640.1 KOO23534.1 - 2.3e-17 63.3 0.0 2.7e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO23534.1 - 4.6e-05 22.9 1.6 0.00034 20.1 0.4 2.6 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO23534.1 - 0.00057 20.1 0.0 0.001 19.2 0.0 1.4 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Abhydrolase_2 PF02230.11 KOO23535.1 - 5.4e-17 61.9 0.0 8.1e-17 61.3 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 KOO23535.1 - 8.6e-10 38.5 0.1 1.5e-09 37.7 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.8 KOO23535.1 - 0.0027 17.1 0.0 0.012 15.1 0.0 1.9 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.2 KOO23535.1 - 0.003 17.4 5.5 0.0088 15.9 3.8 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 KOO23535.1 - 0.0069 15.6 0.1 3.1 6.9 0.1 2.2 1 1 1 2 2 2 2 Prolyl oligopeptidase family Esterase_phd PF10503.4 KOO23535.1 - 0.061 12.5 4.0 3.9 6.6 0.0 3.0 3 0 0 3 3 3 0 Esterase PHB depolymerase Chlorophyllase2 PF12740.2 KOO23535.1 - 0.086 11.7 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Exo_endo_phos PF03372.18 KOO23536.1 - 1.7e-11 44.5 0.0 2.4e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family FAD-oxidase_C PF02913.14 KOO23537.1 - 1e-59 201.8 0.0 1.5e-59 201.3 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 KOO23537.1 - 1.6e-35 121.5 0.5 3.3e-35 120.5 0.4 1.5 1 0 0 1 1 1 1 FAD binding domain PUA PF01472.15 KOO23538.1 - 0.018 14.7 0.2 0.02 14.6 0.1 1.2 1 0 0 1 1 1 0 PUA domain Ribosomal_60s PF00428.14 KOO23538.1 - 0.22 11.9 7.5 0.27 11.6 5.2 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein Shadoo PF14999.1 KOO23538.1 - 0.54 10.1 6.2 0.62 9.9 4.3 1.1 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective MOSC PF03473.12 KOO23539.1 - 5.9e-06 25.7 0.0 1.6e-05 24.3 0.0 1.7 1 1 0 1 1 1 1 MOSC domain Ion_trans_2 PF07885.11 KOO23540.1 - 7.3e-27 92.9 10.1 3.2e-14 52.4 0.5 2.2 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.26 KOO23540.1 - 2.9e-06 26.6 8.2 3e-05 23.3 0.5 2.5 2 1 0 2 2 2 2 Ion transport protein EF-hand_5 PF13202.1 KOO23540.1 - 5e-05 22.4 2.9 0.027 13.8 0.1 3.5 3 0 0 3 3 3 1 EF hand EF-hand_1 PF00036.27 KOO23540.1 - 5.6e-05 22.1 3.3 0.0048 16.1 0.0 3.2 3 1 0 3 3 3 1 EF hand EF-hand_6 PF13405.1 KOO23540.1 - 8e-05 22.2 2.0 0.0042 16.8 0.1 3.2 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.1 KOO23540.1 - 0.00054 20.0 0.9 0.032 14.3 0.0 2.7 2 1 1 3 3 3 2 EF-hand domain pair DUF3647 PF12363.3 KOO23540.1 - 0.00078 19.5 0.4 0.0013 18.8 0.2 1.3 1 0 0 1 1 1 1 Phage protein EF-hand_8 PF13833.1 KOO23540.1 - 1.6 8.4 5.1 3.5 7.3 1.0 2.7 2 1 1 3 3 3 0 EF-hand domain pair EF-hand_1 PF00036.27 KOO23541.1 - 1.3e-14 52.3 1.3 7.2e-07 28.0 0.1 2.1 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO23541.1 - 2e-13 49.6 1.0 1.8e-08 33.8 0.1 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO23541.1 - 1.2e-12 46.5 1.0 2.3e-05 23.9 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO23541.1 - 5.1e-12 45.7 0.1 6.3e-12 45.4 0.1 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO23541.1 - 4.4e-10 38.4 3.0 2.9e-05 23.1 0.1 2.2 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.1 KOO23541.1 - 0.0006 19.4 0.5 0.57 9.8 0.0 2.1 2 0 0 2 2 2 2 EF hand Atg14 PF10186.4 KOO23542.1 - 0.046 12.6 23.6 0.13 11.1 5.2 2.0 1 1 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 IPK PF03770.11 KOO23542.1 - 0.14 11.7 4.2 0.18 11.3 2.9 1.3 1 0 0 1 1 1 0 Inositol polyphosphate kinase Microtub_assoc PF07989.6 KOO23542.1 - 1.8 8.4 7.7 0.53 10.1 0.5 3.2 2 1 1 3 3 3 0 Microtubule associated Spc24 PF08286.6 KOO23542.1 - 9.7 5.9 14.9 0.59 9.8 1.9 2.7 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 ART PF01129.13 KOO23544.1 - 5.7e-12 45.2 0.0 7.1e-12 44.8 0.0 1.0 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.9 KOO23544.1 - 2.1e-06 27.0 0.0 2.7e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme ABC2_membrane PF01061.19 KOO23546.1 - 2.7e-27 95.2 11.2 2.7e-27 95.2 7.8 1.6 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.22 KOO23546.1 - 9.4e-24 84.2 0.0 1.5e-23 83.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 KOO23546.1 - 3.9e-09 36.8 0.0 0.00074 19.5 0.0 2.2 1 1 0 2 2 2 2 AAA domain ABC2_membrane_3 PF12698.2 KOO23546.1 - 0.0014 17.7 2.3 0.0014 17.7 1.6 1.9 2 0 0 2 2 2 1 ABC-2 family transporter protein DUF258 PF03193.11 KOO23546.1 - 0.0014 17.7 0.0 0.0022 17.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 KOO23546.1 - 0.0028 17.1 0.2 0.0075 15.7 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.1 KOO23546.1 - 0.0065 16.8 0.1 0.0096 16.2 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 KOO23546.1 - 0.017 14.5 0.6 0.053 12.9 0.1 1.9 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.14 KOO23546.1 - 0.021 14.0 0.0 1.7 7.8 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 KOO23546.1 - 0.033 14.1 1.9 0.14 12.0 1.3 2.1 1 1 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.1 KOO23546.1 - 0.071 12.6 0.1 0.17 11.4 0.1 1.6 1 0 0 1 1 1 0 AAA domain EF-hand_7 PF13499.1 KOO23547.1 - 1.1e-13 51.0 0.1 2e-13 50.2 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO23547.1 - 6.5e-13 46.9 2.0 1.6e-06 26.9 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO23547.1 - 3.4e-11 42.0 0.4 2.1e-06 27.1 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO23547.1 - 9.7e-09 34.7 2.5 2.1e-06 27.2 0.1 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO23547.1 - 1.3e-06 27.4 1.3 0.00016 20.8 0.1 2.6 2 0 0 2 2 2 2 EF hand Peptidase_S10 PF00450.17 KOO23548.1 - 8.7e-71 239.2 0.1 2.5e-69 234.4 0.1 2.0 1 1 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.2 KOO23548.1 - 0.00019 21.4 0.0 0.00048 20.0 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family TPR_11 PF13414.1 KOO23550.1 - 4.4e-10 39.0 3.2 3.7e-06 26.4 0.0 3.1 3 0 0 3 3 3 2 TPR repeat TPR_16 PF13432.1 KOO23550.1 - 4.4e-05 24.0 1.6 0.0013 19.3 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO23550.1 - 0.00015 21.2 3.0 1.1 8.9 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO23550.1 - 0.00079 19.2 2.3 0.0014 18.4 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO23550.1 - 0.0009 18.9 3.2 0.4 10.7 0.1 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO23550.1 - 0.01 15.9 0.4 0.048 13.8 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO23550.1 - 0.02 14.7 0.5 13 5.7 0.0 3.6 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.1 KOO23550.1 - 0.044 13.5 0.3 0.5 10.2 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Sfi1_C PF10638.4 KOO23550.1 - 0.11 12.9 0.0 0.26 11.7 0.0 1.6 1 0 0 1 1 1 0 Spindle body associated protein C-terminus TPR_6 PF13174.1 KOO23550.1 - 0.74 10.4 4.3 2.6 8.7 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat UCH PF00443.24 KOO23552.1 - 4.4e-36 124.3 0.0 5.1e-36 124.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOO23552.1 - 1.8e-18 67.0 0.0 2.1e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase EF-hand_1 PF00036.27 KOO23553.1 - 6.4e-13 47.0 1.2 5e-06 25.4 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO23553.1 - 1.9e-11 43.4 1.0 5.6e-07 29.0 0.1 3.3 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.1 KOO23553.1 - 3.9e-11 42.9 1.5 1e-10 41.5 0.1 2.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO23553.1 - 4.4e-10 38.5 5.3 0.0004 20.0 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.1 KOO23553.1 - 1.7e-08 33.4 3.2 0.00011 21.3 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.1 KOO23553.1 - 0.032 13.9 0.3 8.6 6.1 0.0 3.0 3 0 0 3 3 3 0 EF hand zf-RING_2 PF13639.1 KOO23554.1 - 8.7e-10 38.2 11.4 1.4e-09 37.5 7.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 KOO23554.1 - 5.6e-06 25.9 10.9 1e-05 25.0 7.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 KOO23554.1 - 2.6e-05 24.2 6.5 4e-05 23.6 4.5 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 KOO23554.1 - 3.1e-05 23.8 8.9 3.1e-05 23.8 6.2 1.9 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO23554.1 - 0.00012 21.6 8.1 0.00022 20.8 5.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO23554.1 - 0.00015 21.3 9.8 0.00026 20.6 6.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 KOO23554.1 - 0.0085 15.7 7.1 0.018 14.7 4.9 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.1 KOO23554.1 - 0.019 14.5 6.9 0.033 13.7 4.8 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.1 KOO23554.1 - 0.041 13.6 5.6 0.11 12.2 3.9 1.8 1 1 0 1 1 1 0 zf-RING of BARD1-type protein FYVE_2 PF02318.11 KOO23554.1 - 0.071 13.0 2.1 0.093 12.6 1.5 1.2 1 0 0 1 1 1 0 FYVE-type zinc finger zf-Apc11 PF12861.2 KOO23554.1 - 0.11 12.3 7.4 0.26 11.1 5.0 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-UDP PF14569.1 KOO23554.1 - 0.14 11.9 1.6 0.2 11.3 1.1 1.2 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-Nse PF11789.3 KOO23554.1 - 0.54 9.8 5.1 0.98 8.9 3.5 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit PHD PF00628.24 KOO23554.1 - 0.95 9.2 13.7 0.17 11.6 6.6 2.0 2 1 0 2 2 2 0 PHD-finger zf-HIT PF04438.11 KOO23554.1 - 4.3 7.0 8.2 4.3 7.0 0.9 3.0 3 0 0 3 3 3 0 HIT zinc finger DUF4605 PF15378.1 KOO23555.1 - 0.027 14.1 1.2 0.047 13.3 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4605) zf-CCCH PF00642.19 KOO23556.1 - 1.4e-05 24.6 7.0 0.00015 21.3 0.2 2.9 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) O-FucT PF10250.4 KOO23556.1 - 2.3e-05 23.6 0.1 1 8.3 0.0 3.3 3 1 0 3 3 3 3 GDP-fucose protein O-fucosyltransferase zf-CCCH_2 PF14608.1 KOO23556.1 - 3.5 7.7 7.7 15 5.7 0.2 3.1 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type Pkinase PF00069.20 KOO23557.1 - 1e-49 169.0 0.0 1.8e-49 168.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO23557.1 - 7.8e-22 77.5 0.0 7.2e-12 44.9 0.0 3.1 2 1 0 2 2 2 2 Protein tyrosine kinase YrbL-PhoP_reg PF10707.4 KOO23557.1 - 0.13 11.6 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.18 KOO23557.1 - 0.18 11.5 0.0 0.18 11.5 0.0 2.4 2 1 0 2 2 2 0 Phosphotransferase enzyme family Pentapeptide_4 PF13599.1 KOO23558.1 - 1.1e-70 233.3 0.0 1.4e-09 37.6 0.0 12.4 5 2 8 14 14 14 14 Pentapeptide repeats (9 copies) Ribosomal_L13e PF01294.13 KOO23558.1 - 0.0097 15.3 17.8 10 5.5 0.0 11.4 8 4 7 15 15 15 1 Ribosomal protein L13e N_methyl_2 PF13544.1 KOO23558.1 - 0.018 14.5 2.1 3.3 7.3 0.0 5.1 4 0 0 4 4 4 0 Type IV pilin N-term methylation site GFxxxE XK-related PF09815.4 KOO23558.1 - 0.098 11.6 4.7 0.17 10.8 3.2 1.3 1 0 0 1 1 1 0 XK-related protein Ank_2 PF12796.2 KOO23559.1 - 4.5e-29 100.6 4.1 3.4e-15 56.1 0.5 1.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO23559.1 - 1.4e-14 53.0 2.7 7.1e-07 28.7 0.1 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 KOO23559.1 - 8.3e-12 44.9 1.8 2.5e-07 30.7 0.1 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO23559.1 - 8.3e-11 42.1 0.7 2.3e-10 40.6 0.2 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO23559.1 - 4.7e-10 38.7 0.1 0.0008 19.4 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat GATase PF00117.23 KOO23560.1 - 1.3e-36 125.8 0.0 2.3e-36 125.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.17 KOO23560.1 - 7.9e-17 60.7 0.0 5e-16 58.2 0.0 2.0 1 1 0 1 1 1 1 GMP synthase C terminal domain Peptidase_C26 PF07722.8 KOO23560.1 - 1.6e-16 60.4 0.0 3.2e-16 59.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 NAD_synthase PF02540.12 KOO23560.1 - 1.4e-06 27.4 0.0 2.5e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 NAD synthase QueC PF06508.8 KOO23560.1 - 0.00017 20.9 0.0 0.00052 19.3 0.0 1.7 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC ThiI PF02568.9 KOO23560.1 - 0.00051 19.5 0.0 0.0054 16.2 0.0 2.3 3 0 0 3 3 3 1 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.11 KOO23560.1 - 0.00056 18.5 0.1 0.00096 17.8 0.0 1.4 1 0 0 1 1 1 1 tRNA methyl transferase Asn_synthase PF00733.16 KOO23560.1 - 0.0011 18.4 0.1 0.0018 17.7 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase ATP_bind_3 PF01171.15 KOO23560.1 - 0.0044 16.5 0.2 0.023 14.2 0.0 2.0 2 0 0 2 2 2 1 PP-loop family PAPS_reduct PF01507.14 KOO23560.1 - 0.0086 15.9 0.0 0.1 12.4 0.0 2.0 2 0 0 2 2 2 1 Phosphoadenosine phosphosulfate reductase family Arginosuc_synth PF00764.14 KOO23560.1 - 0.019 13.9 0.0 0.028 13.4 0.0 1.2 1 0 0 1 1 1 0 Arginosuccinate synthase Myosin_head PF00063.16 KOO23561.1 - 1.6e-183 611.4 0.0 2.3e-183 610.9 0.0 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) WD40 PF00400.27 KOO23561.1 - 1.9e-20 71.8 15.7 1.2e-07 31.3 0.1 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat Tub PF01167.13 KOO23561.1 - 1.3e-08 34.1 0.0 0.00025 20.1 0.0 2.4 1 1 1 2 2 2 2 Tub family AAA_22 PF13401.1 KOO23561.1 - 0.0043 17.2 0.0 0.018 15.1 0.0 2.1 1 0 0 1 1 1 1 AAA domain WW PF00397.21 KOO23561.1 - 0.013 15.3 0.0 0.026 14.3 0.0 1.6 1 0 0 1 1 1 0 WW domain Nup160 PF11715.3 KOO23561.1 - 0.019 13.1 1.8 0.56 8.2 0.0 2.3 1 1 1 2 2 2 0 Nucleoporin Nup120/160 DUF3527 PF12043.3 KOO23561.1 - 0.025 14.1 0.0 0.067 12.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3527) AAA_16 PF13191.1 KOO23561.1 - 0.025 14.5 0.1 0.025 14.5 0.1 2.9 2 1 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.1 KOO23561.1 - 0.072 13.4 0.0 0.21 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 KOO23561.1 - 0.1 13.4 0.1 0.34 11.7 0.1 1.9 1 0 0 1 1 1 0 AAA domain Hpr_kinase_C PF07475.7 KOO23561.1 - 0.12 11.6 0.1 0.42 9.9 0.0 1.9 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain DUF4164 PF13747.1 KOO23562.1 - 0.011 15.8 0.7 0.049 13.7 0.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) DUF4398 PF14346.1 KOO23562.1 - 0.014 15.4 0.4 0.017 15.1 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4398) DUF2096 PF09869.4 KOO23562.1 - 0.058 13.2 0.2 0.077 12.8 0.1 1.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2096) ketoacyl-synt PF00109.21 KOO23563.1 - 0.0018 17.8 0.0 0.0082 15.6 0.0 2.2 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain IFT43 PF15305.1 KOO23563.1 - 0.077 13.0 0.2 0.14 12.1 0.2 1.5 1 1 0 1 1 1 0 Intraflagellar transport protein 43 Ras PF00071.17 KOO23565.1 - 7.7e-14 51.3 0.0 1.6e-07 30.8 0.0 2.2 2 0 0 2 2 2 2 Ras family Miro PF08477.8 KOO23565.1 - 0.00021 21.7 0.0 0.2 12.1 0.0 2.4 2 0 0 2 2 2 2 Miro-like protein GTP_EFTU PF00009.22 KOO23565.1 - 0.00073 19.0 0.0 0.11 11.9 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOO23565.1 - 0.0068 16.3 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.16 KOO23565.1 - 0.0076 15.5 0.0 0.15 11.2 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_22 PF13401.1 KOO23565.1 - 0.012 15.7 0.0 2.1 8.5 0.0 2.7 2 1 1 3 3 3 0 AAA domain AAA_17 PF13207.1 KOO23565.1 - 0.015 16.0 0.5 0.053 14.3 0.1 2.2 2 2 0 2 2 2 0 AAA domain SRPRB PF09439.5 KOO23565.1 - 0.022 13.9 0.0 1.1 8.4 0.0 2.1 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.1 KOO23565.1 - 0.028 14.3 0.1 0.094 12.6 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.1 KOO23565.1 - 0.074 13.3 0.0 0.28 11.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 KOO23565.1 - 0.092 12.4 0.0 0.23 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 KOO23565.1 - 0.14 11.9 0.0 2.9 7.7 0.0 2.4 2 0 0 2 2 2 0 Part of AAA domain DUF4201 PF13870.1 KOO23567.1 - 2.3e-46 157.4 27.4 2.3e-46 157.4 19.0 2.9 2 1 1 3 3 3 2 Domain of unknown function (DUF4201) DUF4498 PF14926.1 KOO23568.1 - 1.2e-65 221.1 0.0 1.3e-65 221.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4498) Bestrophin PF01062.16 KOO23569.1 - 8.1e-25 87.3 0.1 7.1e-14 51.4 0.0 2.1 2 0 0 2 2 2 2 Bestrophin, RFP-TM, chloride channel SBBP PF06739.6 KOO23570.1 - 1e-06 28.4 24.4 0.029 14.1 1.1 3.7 3 0 0 3 3 3 3 Beta-propeller repeat Dynein_heavy PF03028.10 KOO23572.1 - 9.5e-213 708.1 0.0 1.6e-212 707.4 0.0 1.3 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.8 KOO23572.1 - 9.7e-130 432.7 6.4 1.9e-129 431.7 0.1 2.6 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 KOO23572.1 - 2.6e-89 298.7 0.0 5.7e-89 297.5 0.0 1.6 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.2 KOO23572.1 - 3e-69 232.9 0.1 6.4e-69 231.9 0.1 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 KOO23572.1 - 3.1e-53 179.9 2.6 5.9e-53 179.0 0.4 2.4 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 MT PF12777.2 KOO23572.1 - 4.6e-39 134.1 14.6 1.2e-38 132.7 10.1 1.7 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 KOO23572.1 - 1.7e-34 119.1 0.0 4.9e-34 117.6 0.0 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_5 PF07728.9 KOO23572.1 - 7.5e-13 48.3 0.0 0.0038 16.9 0.0 5.6 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOO23572.1 - 4.5e-05 23.5 4.9 0.94 9.4 0.0 5.6 5 0 0 5 5 4 1 AAA ATPase domain AAA PF00004.24 KOO23572.1 - 0.0034 17.5 2.7 0.45 10.7 0.0 4.7 5 0 0 5 5 4 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 KOO23572.1 - 0.0059 16.7 0.6 1.2 9.3 0.0 3.7 4 0 0 4 4 4 1 RNA helicase AAA_22 PF13401.1 KOO23572.1 - 0.0092 16.1 1.1 14 5.8 0.0 4.4 3 0 0 3 3 3 0 AAA domain AAA_17 PF13207.1 KOO23572.1 - 0.012 16.4 0.4 1.8 9.4 0.0 3.9 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.1 KOO23572.1 - 0.091 13.0 0.1 14 5.9 0.0 3.4 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 KOO23572.1 - 2.3 8.0 5.2 4.4 7.1 0.0 3.6 4 0 0 4 4 3 0 Part of AAA domain Resistin PF06954.6 KOO23573.1 - 0.0017 18.6 5.4 0.31 11.3 0.3 2.1 1 1 1 2 2 2 2 Resistin He_PIG PF05345.7 KOO23573.1 - 5 7.2 7.6 27 4.8 0.2 4.0 3 2 0 3 3 3 0 Putative Ig domain Arm PF00514.18 KOO23574.1 - 3.6e-34 115.4 35.5 9.3e-06 25.2 1.0 7.6 7 0 0 7 7 7 6 Armadillo/beta-catenin-like repeat U-box PF04564.10 KOO23574.1 - 1.9e-10 40.5 0.0 4.3e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO23574.1 - 8.2e-06 25.2 0.0 1.7e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Arm_2 PF04826.8 KOO23574.1 - 6.3e-05 22.1 1.4 0.095 11.7 0.1 3.2 1 1 2 3 3 3 2 Armadillo-like Atx10homo_assoc PF09759.4 KOO23574.1 - 0.00027 20.6 1.5 3.9 7.2 0.0 4.4 4 1 0 4 4 4 2 Spinocerebellar ataxia type 10 protein domain zf-RING_UBOX PF13445.1 KOO23574.1 - 0.0098 15.5 0.0 0.04 13.6 0.0 2.1 2 0 0 2 2 2 1 RING-type zinc-finger Succ_CoA_lig PF13607.1 KOO23574.1 - 1.1 8.8 36.9 2 8.0 0.8 6.0 2 2 3 6 6 6 0 Succinyl-CoA ligase like flavodoxin domain DUF3584 PF12128.3 KOO23575.1 - 0.077 10.3 15.4 0.093 10.0 10.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) LIN37 PF15306.1 KOO23575.1 - 0.1 12.6 6.9 0.16 11.9 4.8 1.3 1 0 0 1 1 1 0 LIN37 Mnd1 PF03962.10 KOO23575.1 - 0.8 9.3 10.5 1.1 8.8 7.3 1.2 1 0 0 1 1 1 0 Mnd1 family T2SF PF00482.18 KOO23575.1 - 4.4 7.2 6.3 6.4 6.7 4.2 1.5 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein F YlqD PF11068.3 KOO23575.1 - 6.4 6.8 8.7 15 5.6 6.0 1.6 1 1 0 1 1 1 0 YlqD protein BRCT PF00533.21 KOO23576.1 - 6.1e-07 29.4 0.0 0.016 15.3 0.0 2.3 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain FHA PF00498.21 KOO23576.1 - 0.00079 19.5 0.0 0.0013 18.7 0.0 1.4 1 0 0 1 1 1 1 FHA domain ART PF01129.13 KOO23577.1 - 0.00016 20.8 0.0 0.0006 18.9 0.0 1.9 1 1 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Cep57_CLD_2 PF14197.1 KOO23577.1 - 0.0062 16.4 8.4 0.0062 16.4 5.8 2.1 2 0 0 2 2 2 1 Centrosome localisation domain of PPC89 CENP-F_leu_zip PF10473.4 KOO23577.1 - 0.0099 15.7 5.4 0.02 14.7 3.8 1.4 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HAP1_N PF04849.8 KOO23577.1 - 0.051 12.5 4.4 0.098 11.5 3.1 1.4 1 0 0 1 1 1 0 HAP1 N-terminal conserved region TPR_10 PF13374.1 KOO23577.1 - 0.052 13.4 0.4 3.3 7.7 0.0 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat FANCI_S1-cap PF14674.1 KOO23577.1 - 0.1 12.6 0.6 0.48 10.5 0.4 2.1 1 0 0 1 1 1 0 FANCI solenoid 1 cap ADPrib_exo_Tox PF03496.9 KOO23577.1 - 0.13 11.4 0.0 0.24 10.5 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosyltransferase exoenzyme ATG16 PF08614.6 KOO23577.1 - 0.14 11.9 7.1 0.35 10.6 4.9 1.6 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF3584 PF12128.3 KOO23577.1 - 0.27 8.5 3.8 0.42 7.8 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) IncA PF04156.9 KOO23577.1 - 0.48 10.0 5.9 0.075 12.6 0.9 1.9 2 0 0 2 2 2 0 IncA protein DUF904 PF06005.7 KOO23577.1 - 0.64 10.3 12.5 1.1 9.5 0.7 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF904) GAS PF13851.1 KOO23577.1 - 1.2 8.3 5.1 2.1 7.5 3.6 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding 2OG-FeII_Oxy_3 PF13640.1 KOO23578.1 - 0.00013 22.3 0.0 0.00017 22.0 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO23578.1 - 0.0047 17.1 0.0 0.0063 16.7 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily GFO_IDH_MocA PF01408.17 KOO23579.1 - 2.2e-17 63.6 0.1 7.7e-17 61.9 0.1 1.9 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.19 KOO23579.1 - 0.0073 16.5 0.0 0.018 15.3 0.0 1.7 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain IDO PF01231.13 KOO23580.1 - 2e-52 178.0 0.0 3.8e-52 177.1 0.0 1.4 1 1 0 1 1 1 1 Indoleamine 2,3-dioxygenase Nucleotid_trans PF03407.11 KOO23581.1 - 3.2e-06 27.1 0.0 1.6e-05 24.7 0.0 1.9 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Wzz PF02706.10 KOO23582.1 - 0.0087 15.8 2.4 0.25 11.1 0.5 2.5 2 1 0 2 2 2 2 Chain length determinant protein Amidase PF01425.16 KOO23583.1 - 4.7e-69 233.3 0.0 9e-69 232.4 0.0 1.4 1 1 0 1 1 1 1 Amidase DUF1876 PF08962.6 KOO23583.1 - 0.17 11.6 1.8 6.2 6.6 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1876) Metallophos PF00149.23 KOO23584.1 - 5.4e-12 45.5 0.1 7.5e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KOO23584.1 - 3e-05 23.8 0.0 7.4e-05 22.6 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain HECT PF00632.20 KOO23585.1 - 3.1e-83 279.5 0.0 4.2e-83 279.1 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DnaJ PF00226.26 KOO23586.1 - 5.5e-28 96.4 4.7 9.6e-28 95.7 3.2 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 KOO23586.1 - 0.029 14.2 0.0 0.049 13.5 0.0 1.4 1 0 0 1 1 1 0 DnaJ C terminal domain Enkurin PF13864.1 KOO23586.1 - 0.04 14.1 1.3 0.068 13.3 0.9 1.3 1 0 0 1 1 1 0 Calmodulin-binding Ank_2 PF12796.2 KOO23588.1 - 6.7e-21 74.4 4.5 8.3e-12 45.2 1.3 2.7 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO23588.1 - 2.9e-18 64.6 6.8 4e-06 26.3 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.1 KOO23588.1 - 5.2e-15 55.1 2.9 0.00018 21.6 0.0 5.1 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Chorein_N PF12624.2 KOO23588.1 - 3.2e-11 42.7 0.0 6.7e-11 41.7 0.0 1.5 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter Ank_3 PF13606.1 KOO23588.1 - 2.2e-10 39.7 4.0 0.0011 18.9 0.0 5.4 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.1 KOO23588.1 - 1.9e-09 37.7 0.3 4.8e-07 30.1 0.0 3.8 2 1 2 4 4 4 1 Ankyrin repeats (many copies) Strep_SA_rep PF06696.6 KOO23589.1 - 0.11 12.2 5.6 1.1 9.0 0.7 3.1 3 0 0 3 3 3 0 Streptococcal surface antigen repeat Herpes_BLRF2 PF05812.7 KOO23589.1 - 0.19 11.5 1.9 0.24 11.1 0.2 1.9 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein Toluene_X PF03349.11 KOO23589.1 - 9.3 4.4 8.5 33 2.6 5.9 1.8 1 1 0 1 1 1 0 Outer membrane protein transport protein (OMPP1/FadL/TodX) Peptidase_C97 PF05903.9 KOO23591.1 - 8.7e-12 45.0 0.0 1.2e-11 44.6 0.0 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain Myb_DNA-binding PF00249.26 KOO23592.1 - 3.8e-07 30.0 0.1 6.7e-07 29.2 0.1 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain DnaJ PF00226.26 KOO23593.1 - 8.7e-12 44.6 0.2 8.7e-12 44.6 0.2 2.4 2 0 0 2 2 2 1 DnaJ domain Integrin_b_cyt PF08725.6 KOO23593.1 - 0.39 10.1 3.2 2 7.8 0.0 2.3 2 0 0 2 2 2 0 Integrin beta cytoplasmic domain Peptidase_M49 PF03571.10 KOO23594.1 - 1.6e-199 663.6 0.0 5.2e-185 615.6 0.0 2.0 2 0 0 2 2 2 2 Peptidase family M49 Methyltransf_11 PF08241.7 KOO23595.1 - 3.3e-10 40.3 0.0 6.5e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO23595.1 - 3.2e-05 23.5 0.0 4.6e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO23595.1 - 3.8e-05 22.9 0.0 5.3e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 KOO23595.1 - 0.0014 18.9 0.0 0.0079 16.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO23595.1 - 0.0018 17.9 0.0 0.0026 17.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO23595.1 - 0.0025 18.2 0.0 0.0043 17.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 KOO23595.1 - 0.023 14.3 0.0 0.03 13.9 0.0 1.2 1 0 0 1 1 1 0 Hypothetical methyltransferase DUF1162 PF06650.7 KOO23596.1 - 3.6e-10 39.5 0.0 2.8e-09 36.5 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1162) Ank_2 PF12796.2 KOO23597.1 - 2.2e-32 111.2 2.8 4.3e-13 49.4 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO23597.1 - 1.9e-28 96.8 7.6 1.1e-06 28.1 0.0 6.6 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.1 KOO23597.1 - 1.5e-23 82.2 5.1 1.1e-07 31.8 0.0 5.0 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO23597.1 - 2.5e-22 78.8 1.0 8e-05 23.0 0.0 5.5 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO23597.1 - 9.6e-22 74.9 3.4 0.00089 19.2 0.0 6.6 6 0 0 6 6 6 4 Ankyrin repeat DUF413 PF04219.7 KOO23597.1 - 0.14 11.9 0.0 0.38 10.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF Apt1 PF10351.4 KOO23597.1 - 0.33 9.7 0.0 0.5 9.1 0.0 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain ABC1 PF03109.11 KOO23598.1 - 2.5e-28 98.4 0.0 4.3e-28 97.6 0.0 1.4 1 0 0 1 1 1 1 ABC1 family Pkinase_Tyr PF07714.12 KOO23598.1 - 0.043 12.8 0.0 1.3 8.0 0.0 2.2 1 1 0 1 1 1 0 Protein tyrosine kinase APH PF01636.18 KOO23598.1 - 0.26 11.0 3.8 0.3 10.7 0.2 2.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family UQ_con PF00179.21 KOO23599.1 - 7.6e-37 125.8 0.0 9e-37 125.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.8 KOO23599.1 - 0.022 14.4 0.0 0.033 13.8 0.0 1.3 1 0 0 1 1 1 0 UEV domain RWD PF05773.17 KOO23599.1 - 0.11 12.4 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 RWD domain NUDIX-like PF09296.6 KOO23600.1 - 0.11 12.9 0.0 0.26 11.6 0.0 1.8 1 1 0 1 1 1 0 NADH pyrophosphatase-like rudimentary NUDIX domain SART-1 PF03343.8 KOO23601.1 - 0.0003 19.3 2.2 0.00036 19.0 1.5 1.1 1 0 0 1 1 1 1 SART-1 family TMF_TATA_bd PF12325.3 KOO23601.1 - 0.0047 16.6 1.8 0.033 13.9 0.1 2.1 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding DUF904 PF06005.7 KOO23601.1 - 0.0055 16.9 2.5 0.01 16.0 1.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF904) AAA_13 PF13166.1 KOO23601.1 - 0.0059 15.1 2.0 0.0072 14.8 1.4 1.0 1 0 0 1 1 1 1 AAA domain APG6 PF04111.7 KOO23601.1 - 0.01 14.9 2.9 0.014 14.4 2.0 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 CCDC155 PF14662.1 KOO23601.1 - 0.013 15.1 6.6 0.024 14.2 4.6 1.4 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 DUF2951 PF11166.3 KOO23601.1 - 0.018 14.8 1.5 0.043 13.6 0.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) DivIC PF04977.10 KOO23601.1 - 0.02 14.3 6.3 0.021 14.2 1.0 2.4 2 0 0 2 2 2 0 Septum formation initiator CASP_C PF08172.7 KOO23601.1 - 0.034 13.1 1.7 0.091 11.7 1.2 1.7 1 1 0 1 1 1 0 CASP C terminal DUF4140 PF13600.1 KOO23601.1 - 0.042 14.2 2.1 0.042 14.2 1.5 2.3 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) End3 PF12761.2 KOO23601.1 - 0.065 12.8 3.1 0.077 12.6 2.2 1.2 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 bZIP_2 PF07716.10 KOO23601.1 - 0.073 12.8 1.2 0.19 11.5 0.8 1.8 1 0 0 1 1 1 0 Basic region leucine zipper DUF2968 PF11180.3 KOO23601.1 - 0.1 11.9 11.4 0.17 11.2 7.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Lzipper-MIP1 PF14389.1 KOO23601.1 - 0.19 11.8 3.0 0.97 9.5 0.8 2.1 1 1 2 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 DUF3584 PF12128.3 KOO23601.1 - 0.26 8.5 9.4 0.32 8.2 6.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) GAS PF13851.1 KOO23601.1 - 0.26 10.4 6.6 0.086 12.0 2.2 1.7 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Fzo_mitofusin PF04799.8 KOO23601.1 - 0.3 10.4 3.8 2.7 7.3 0.7 2.4 1 1 2 3 3 3 0 fzo-like conserved region bZIP_1 PF00170.16 KOO23601.1 - 0.32 10.9 2.4 0.66 9.9 1.6 1.6 1 0 0 1 1 1 0 bZIP transcription factor MscS_porin PF12795.2 KOO23601.1 - 0.53 9.5 9.3 0.35 10.1 1.9 2.1 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain Tropomyosin PF00261.15 KOO23601.1 - 0.54 9.2 9.0 0.12 11.3 2.9 1.9 1 1 1 2 2 2 0 Tropomyosin Prefoldin_2 PF01920.15 KOO23601.1 - 0.71 9.6 6.1 1.7 8.4 1.6 2.2 2 0 0 2 2 2 0 Prefoldin subunit Ax_dynein_light PF10211.4 KOO23601.1 - 1.1 9.0 6.1 0.95 9.2 3.0 1.7 1 1 1 2 2 2 0 Axonemal dynein light chain Macoilin PF09726.4 KOO23601.1 - 2 6.5 7.0 3.3 5.8 4.8 1.3 1 1 0 1 1 1 0 Transmembrane protein DUF724 PF05266.9 KOO23601.1 - 2 7.9 6.9 1.9 8.0 3.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF724) FlxA PF14282.1 KOO23601.1 - 2.1 8.3 10.7 0.37 10.7 2.8 2.2 1 1 1 2 2 2 0 FlxA-like protein IncA PF04156.9 KOO23601.1 - 2.4 7.7 6.9 4.6 6.7 4.8 1.6 1 1 0 1 1 1 0 IncA protein HR1 PF02185.11 KOO23601.1 - 3.6 7.4 7.4 0.77 9.5 0.9 2.6 2 1 1 3 3 3 0 Hr1 repeat ADIP PF11559.3 KOO23601.1 - 6.9 6.5 8.4 1.5 8.6 2.8 1.9 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding U-box PF04564.10 KOO23602.1 - 7e-17 61.1 0.0 9.9e-17 60.6 0.0 1.2 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO23602.1 - 0.00022 20.6 0.0 0.00038 19.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit TSA PF03249.8 KOO23602.1 - 0.21 10.0 2.0 0.23 9.9 1.4 1.1 1 0 0 1 1 1 0 Type specific antigen DUF2360 PF10152.4 KOO23602.1 - 3.4 7.9 6.3 4.4 7.5 4.4 1.2 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) Ank_2 PF12796.2 KOO23603.1 - 2.9e-122 399.3 89.9 7.4e-18 64.6 2.0 7.0 1 1 10 11 11 11 11 Ankyrin repeats (3 copies) Ank PF00023.25 KOO23603.1 - 1.5e-58 191.8 64.6 1.1e-05 25.0 0.3 13.2 13 0 0 13 13 13 12 Ankyrin repeat Ank_4 PF13637.1 KOO23603.1 - 1.4e-53 178.3 19.2 1.6e-08 34.8 0.1 9.9 6 4 5 11 11 11 10 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO23603.1 - 3.3e-49 163.7 45.3 2.3e-07 30.8 0.9 11.7 1 1 9 11 11 11 11 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO23603.1 - 2.4e-34 113.9 27.7 0.019 15.1 0.0 12.7 12 0 0 12 12 12 12 Ankyrin repeat Pkinase PF00069.20 KOO23603.1 - 7.4e-31 107.2 0.0 1.2e-30 106.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO23603.1 - 6.9e-23 81.0 0.0 1.3e-22 80.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4182 PF13790.1 KOO23603.1 - 6.3e-07 29.0 3.3 0.93 9.3 0.0 6.8 6 0 0 6 6 6 1 Domain of unknown function (DUF4182) Kinase-like PF14531.1 KOO23603.1 - 0.0094 14.9 0.0 0.039 12.9 0.0 2.0 1 0 0 1 1 1 1 Kinase-like LIN37 PF15306.1 KOO23603.1 - 0.06 13.3 1.1 1.6e+02 2.2 0.0 5.2 6 0 0 6 6 6 0 LIN37 TP_methylase PF00590.15 KOO23604.1 - 9.9e-19 67.8 0.3 1.6e-18 67.1 0.2 1.4 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Na_sulph_symp PF00939.14 KOO23605.1 - 8.1e-26 90.9 22.2 1.2e-25 90.4 15.4 1.4 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region SPX PF03105.14 KOO23605.1 - 3e-11 43.6 0.1 7.3e-05 22.6 0.0 2.1 1 1 1 2 2 2 2 SPX domain UvrC_HhH_N PF08459.6 KOO23606.1 - 3e-24 85.3 0.0 2.2e-22 79.2 0.0 2.4 2 0 0 2 2 2 1 UvrC Helix-hairpin-helix N-terminal ResIII PF04851.10 KOO23606.1 - 1e-08 35.2 0.0 2.1e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HHH_5 PF14520.1 KOO23606.1 - 2.6e-08 33.9 0.1 1e-07 32.0 0.1 2.0 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.2 KOO23606.1 - 4.7e-06 26.3 0.1 1.6e-05 24.6 0.0 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix motif DEAD PF00270.24 KOO23606.1 - 0.00069 19.1 0.0 0.0013 18.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase HHH PF00633.18 KOO23606.1 - 0.029 14.0 0.0 0.094 12.4 0.0 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix motif DAP3 PF10236.4 KOO23606.1 - 0.04 12.8 0.0 0.071 12.0 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 HHH_3 PF12836.2 KOO23606.1 - 0.12 12.3 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif PIF1 PF05970.9 KOO23606.1 - 0.47 9.3 0.1 1.2 8.0 0.0 1.6 2 0 0 2 2 2 0 PIF1-like helicase PCI PF01399.22 KOO23607.1 - 3.5e-16 59.4 1.0 7.7e-15 55.1 0.1 3.1 3 0 0 3 3 3 1 PCI domain RPN7 PF10602.4 KOO23607.1 - 0.0023 17.3 0.5 0.01 15.2 0.0 2.1 2 1 0 2 2 2 1 26S proteasome subunit RPN7 TPR_16 PF13432.1 KOO23607.1 - 0.05 14.2 0.9 0.42 11.3 0.2 2.8 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_21 PF09976.4 KOO23607.1 - 0.074 12.9 0.2 0.074 12.9 0.2 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Flavi_NS5 PF00972.15 KOO23607.1 - 0.1 10.4 0.1 0.15 9.8 0.0 1.2 1 0 0 1 1 1 0 Flavivirus RNA-directed RNA polymerase TPR_12 PF13424.1 KOO23607.1 - 0.11 12.4 6.7 1.2 9.1 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.1 KOO23607.1 - 0.12 12.7 6.8 0.23 11.8 0.3 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOO23607.1 - 0.25 11.0 3.3 2.8 7.7 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO23607.1 - 0.26 12.0 3.6 3.9 8.3 0.2 4.3 4 1 1 5 5 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO23607.1 - 0.61 10.1 3.9 33 4.7 0.2 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_20 PF14561.1 KOO23607.1 - 1.8 8.7 9.4 10 6.3 1.6 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat DUF3493 PF11998.3 KOO23609.1 - 1.1e-09 38.0 0.5 1.8e-09 37.3 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3493) PseudoU_synth_2 PF00849.17 KOO23610.1 - 5e-09 36.2 0.0 6.7e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase Prenylcys_lyase PF07156.9 KOO23611.1 - 1.6e-25 89.7 0.0 2.6e-14 52.9 0.0 3.0 2 1 0 2 2 2 2 Prenylcysteine lyase Amino_oxidase PF01593.19 KOO23611.1 - 6.4e-08 32.1 0.5 0.0023 17.0 0.0 2.6 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 KOO23611.1 - 4.2e-07 29.8 0.3 1.1e-06 28.5 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 KOO23611.1 - 0.00047 19.9 1.0 0.16 11.7 0.1 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding DAO PF01266.19 KOO23611.1 - 0.67 8.7 10.7 5 5.9 7.4 2.2 1 1 0 1 1 1 0 FAD dependent oxidoreductase SHOCT PF09851.4 KOO23612.1 - 0.00023 20.5 0.1 0.00045 19.5 0.1 1.5 1 0 0 1 1 1 1 Short C-terminal domain DMAP_binding PF06464.6 KOO23612.1 - 0.017 15.7 0.0 0.033 14.7 0.0 1.4 1 0 0 1 1 1 0 DMAP1-binding Domain TPR_12 PF13424.1 KOO23613.1 - 0.0004 20.2 14.3 0.0089 15.9 0.2 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat Aminotran_5 PF00266.14 KOO23614.1 - 1.5e-94 316.7 0.0 1.8e-94 316.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 KOO23614.1 - 8e-09 35.0 0.0 1.4e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 KOO23614.1 - 0.00013 21.1 0.1 0.00021 20.4 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.14 KOO23614.1 - 0.047 12.1 0.0 0.072 11.5 0.0 1.3 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain B12-binding PF02310.14 KOO23614.1 - 0.05 13.4 0.1 6.5 6.6 0.0 2.9 2 1 1 3 3 3 0 B12 binding domain Cys_Met_Meta_PP PF01053.15 KOO23614.1 - 0.099 10.9 0.0 0.15 10.2 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme BRCT PF00533.21 KOO23615.1 - 4.8e-10 39.4 0.0 2.3e-07 30.8 0.0 3.1 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 KOO23615.1 - 1.6e-09 37.4 0.7 7.1e-09 35.3 0.0 2.2 3 0 0 3 3 3 1 twin BRCT domain Ank_2 PF12796.2 KOO23616.1 - 1.3e-23 83.0 0.5 4.7e-13 49.2 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO23616.1 - 2.7e-22 77.3 2.4 1.3e-08 34.1 0.6 4.8 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.1 KOO23616.1 - 1e-17 63.7 2.8 1.2e-06 28.5 0.1 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO23616.1 - 2.6e-14 53.2 2.3 2.1e-06 28.0 1.1 3.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO23616.1 - 2.5e-10 39.5 1.6 0.0052 16.9 0.4 4.6 5 0 0 5 5 5 2 Ankyrin repeat EF-hand_1 PF00036.27 KOO23617.1 - 2.5e-21 73.2 4.8 5.8e-05 22.1 0.1 5.9 6 0 0 6 6 6 4 EF hand EF-hand_6 PF13405.1 KOO23617.1 - 3.1e-20 70.1 1.0 0.00054 19.6 0.0 6.7 7 0 0 7 7 7 4 EF-hand domain EF-hand_7 PF13499.1 KOO23617.1 - 3.1e-18 65.6 0.2 2.1e-10 40.5 0.0 4.5 4 1 0 4 4 4 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO23617.1 - 1.8e-14 53.1 0.9 0.00073 19.1 0.1 5.5 5 0 0 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO23617.1 - 4e-11 41.7 2.5 0.00015 20.9 0.1 4.7 4 0 0 4 4 4 2 EF hand CheX PF13690.1 KOO23617.1 - 0.0037 17.0 0.0 0.014 15.2 0.0 1.9 2 0 0 2 2 2 1 Chemotaxis phosphatase CheX Cellulase PF00150.13 KOO23619.1 - 2.6e-10 40.0 0.0 7.9e-10 38.3 0.0 1.8 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CDC37_N PF03234.9 KOO23619.1 - 0.0048 17.2 0.6 0.017 15.4 0.5 1.8 2 0 0 2 2 2 1 Cdc37 N terminal kinase binding TMCO5 PF14992.1 KOO23622.1 - 0.033 13.3 41.3 0.02 14.0 26.5 1.7 1 1 1 2 2 2 0 TMCO5 family GAGA_bind PF06217.7 KOO23622.1 - 4.7 7.0 7.1 5.6 6.8 4.9 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Ion_trans_2 PF07885.11 KOO23623.1 - 1.6e-16 59.7 1.1 2.4e-16 59.2 0.8 1.2 1 0 0 1 1 1 1 Ion channel EF-hand_1 PF00036.27 KOO23623.1 - 0.00015 20.7 0.3 0.029 13.6 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO23623.1 - 0.00022 20.4 0.3 0.014 14.6 0.1 2.6 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO23623.1 - 0.0011 18.6 0.1 0.026 14.3 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.1 KOO23623.1 - 0.0031 17.6 0.1 0.13 12.4 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair VCBS PF13517.1 KOO23624.1 - 7e-114 372.2 134.8 9.1e-14 51.5 3.2 13.2 4 3 9 13 13 13 13 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO23624.1 - 5.8e-63 207.2 131.5 3.1e-06 26.6 0.6 13.8 13 1 0 13 13 13 13 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO23624.1 - 7.5e-22 77.6 51.4 0.088 12.2 0.0 12.9 5 4 8 13 13 13 12 Insecticide toxin TcdB middle/N-terminal region SeleniumBinding PF11524.3 KOO23624.1 - 0.0068 16.5 0.6 35 4.6 0.0 4.4 5 0 0 5 5 5 0 Selenium binding protein Arrestin_N PF00339.24 KOO23624.1 - 0.0081 15.9 0.3 9.5 6.0 0.0 5.7 9 0 0 9 9 9 1 Arrestin (or S-antigen), N-terminal domain YchF-GTPase_C PF06071.8 KOO23625.1 - 1.5e-37 127.1 0.7 3.3e-37 126.1 0.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.18 KOO23625.1 - 2.9e-14 53.0 0.0 6.3e-14 51.9 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KOO23625.1 - 7.9e-06 25.2 0.0 1.8e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_17 PF13207.1 KOO23625.1 - 0.063 14.0 0.4 2.4 8.9 0.3 3.2 1 1 0 1 1 1 0 AAA domain LexA_DNA_bind PF01726.11 KOO23626.1 - 0.11 12.0 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 LexA DNA binding domain Aldedh PF00171.17 KOO23627.1 - 1.5e-138 462.0 0.1 2.3e-137 458.1 0.8 1.9 2 0 0 2 2 2 1 Aldehyde dehydrogenase family Amidohydro_2 PF04909.9 KOO23627.1 - 4.1e-34 118.3 5.4 4.1e-34 118.3 3.8 2.4 3 0 0 3 3 3 1 Amidohydrolase Ribonuc_L-PSP PF01042.16 KOO23627.1 - 1e-22 80.1 0.0 5.8e-22 77.7 0.0 2.4 2 0 0 2 2 2 1 Endoribonuclease L-PSP ABC_tran PF00005.22 KOO23629.1 - 5.8e-19 68.7 0.0 1.3e-18 67.5 0.0 1.7 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 KOO23629.1 - 1.6e-18 67.1 3.6 2.3e-18 66.5 2.5 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_16 PF13191.1 KOO23629.1 - 0.0021 18.0 0.0 0.005 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.1 KOO23629.1 - 0.0035 16.7 0.1 0.0093 15.3 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.1 KOO23629.1 - 0.0038 17.5 0.0 0.0071 16.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.11 KOO23629.1 - 0.019 14.1 0.0 0.033 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 KOO23629.1 - 0.023 14.2 0.0 0.057 12.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.14 KOO23629.1 - 0.045 12.9 0.1 0.35 10.0 0.0 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Adeno_IVa2 PF02456.10 KOO23629.1 - 0.099 11.2 0.0 0.17 10.5 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_22 PF13401.1 KOO23629.1 - 0.11 12.6 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 KOO23629.1 - 0.11 12.9 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein AAA_21 PF13304.1 KOO23629.1 - 0.12 12.3 0.0 0.43 10.4 0.0 1.8 1 1 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 KOO23629.1 - 0.13 11.9 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase T2SE PF00437.15 KOO23629.1 - 0.14 10.9 0.0 0.25 10.2 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein Zeta_toxin PF06414.7 KOO23629.1 - 0.17 10.9 0.1 0.37 9.8 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin Rad17 PF03215.10 KOO23629.1 - 0.21 10.2 0.1 0.34 9.5 0.1 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein ABC_tran PF00005.22 KOO23630.1 - 5.5e-27 94.7 0.0 9.6e-27 93.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 KOO23630.1 - 3.9e-25 88.8 1.8 5.1e-25 88.4 1.3 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.14 KOO23630.1 - 6.8e-08 32.0 0.0 5.4e-06 25.8 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 KOO23630.1 - 0.00012 22.0 0.5 0.0034 17.3 0.1 2.3 2 0 0 2 2 2 1 AAA ATPase domain DUF87 PF01935.12 KOO23630.1 - 0.022 14.6 0.3 0.056 13.2 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function DUF87 Zeta_toxin PF06414.7 KOO23630.1 - 0.041 12.9 0.0 0.1 11.6 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin MMR_HSR1 PF01926.18 KOO23630.1 - 0.048 13.6 0.1 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF815 PF05673.8 KOO23630.1 - 0.057 12.3 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Miro PF08477.8 KOO23630.1 - 0.11 12.9 0.0 0.56 10.7 0.1 2.1 2 0 0 2 2 2 0 Miro-like protein Ion_trans PF00520.26 KOO23631.1 - 1.1e-131 436.0 52.0 3.6e-46 156.9 5.0 4.4 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 KOO23631.1 - 0.00047 18.6 58.7 0.048 12.0 0.4 9.0 8 1 1 9 9 9 7 Polycystin cation channel LRR_6 PF13516.1 KOO23632.1 - 9.2e-07 28.3 0.0 0.024 14.6 0.0 3.1 2 0 0 2 2 2 2 Leucine Rich repeat cNMP_binding PF00027.24 KOO23633.1 - 5.8e-15 54.8 0.0 1e-14 54.0 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain FKBP_C PF00254.23 KOO23634.1 - 3.5e-17 62.2 0.0 5.6e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Rotamase PF00639.16 KOO23634.1 - 8.7e-17 61.6 0.0 1.6e-16 60.7 0.0 1.5 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 KOO23634.1 - 1e-11 45.0 0.0 1.7e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain FKBP_N PF01346.13 KOO23634.1 - 3.9e-05 23.6 0.2 8.2e-05 22.6 0.0 1.6 2 0 0 2 2 2 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Rotamase_2 PF13145.1 KOO23634.1 - 0.051 14.2 0.0 0.097 13.3 0.0 1.5 1 0 0 1 1 1 0 PPIC-type PPIASE domain Rotamase PF00639.16 KOO23635.1 - 9.8e-16 58.2 0.0 1.7e-15 57.4 0.0 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain FKBP_C PF00254.23 KOO23635.1 - 4.1e-15 55.5 0.0 7.4e-15 54.7 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Rotamase_3 PF13616.1 KOO23635.1 - 2.3e-13 50.3 0.0 4.1e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain FKBP_N PF01346.13 KOO23635.1 - 0.00017 21.6 0.0 0.00036 20.5 0.0 1.5 1 0 0 1 1 1 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Aldo_ket_red PF00248.16 KOO23636.1 - 4.3e-47 160.2 0.0 5.6e-47 159.8 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family EF-hand_5 PF13202.1 KOO23637.1 - 2.6e-10 39.1 0.0 1.1e-05 24.5 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.27 KOO23637.1 - 3.1e-10 38.5 0.0 1.9e-06 26.7 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO23637.1 - 1.5e-09 37.8 0.0 1.8e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO23637.1 - 4.8e-09 35.6 0.0 7.8e-07 28.6 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO23637.1 - 1.9e-08 33.4 0.0 3e-06 26.6 0.0 2.5 1 1 1 2 2 2 1 EF-hand domain EF-hand_9 PF14658.1 KOO23637.1 - 0.00091 19.0 0.0 0.0013 18.6 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain TPR_11 PF13414.1 KOO23638.1 - 8.9e-10 38.0 8.7 6e-05 22.6 1.2 3.1 3 1 0 3 3 3 2 TPR repeat TPR_1 PF00515.23 KOO23638.1 - 9.1e-08 31.3 1.7 0.0024 17.3 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO23638.1 - 1.9e-06 27.3 7.8 0.0066 16.2 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat Apc3 PF12895.2 KOO23638.1 - 0.0002 21.4 2.9 0.00058 19.9 0.1 2.8 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 KOO23638.1 - 0.00024 21.3 0.5 0.033 14.5 0.0 4.9 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO23638.1 - 0.0059 16.5 8.2 0.082 12.8 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO23638.1 - 0.0077 16.7 0.1 0.0077 16.7 0.0 4.1 3 2 1 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO23638.1 - 0.015 15.9 0.1 0.015 15.9 0.1 5.4 6 1 1 7 7 6 0 Tetratricopeptide repeat PDZ_2 PF13180.1 KOO23638.1 - 0.024 14.5 0.0 0.082 12.8 0.0 1.9 1 1 0 1 1 1 0 PDZ domain TPR_7 PF13176.1 KOO23638.1 - 0.48 10.3 4.6 22 5.1 0.0 4.2 3 1 0 3 3 3 0 Tetratricopeptide repeat DUF896 PF05979.7 KOO23638.1 - 0.83 9.2 0.0 0.83 9.2 0.0 2.7 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF896) Glyco_transf_25 PF01755.12 KOO23639.1 - 1.1e-05 25.1 0.0 1.7e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) EF-hand_1 PF00036.27 KOO23640.1 - 3.6e-37 122.8 0.5 1.8e-06 26.8 0.3 6.4 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.1 KOO23640.1 - 2.5e-36 120.2 0.7 6.5e-05 22.4 0.0 6.6 6 0 0 6 6 6 6 EF-hand domain EF-hand_5 PF13202.1 KOO23640.1 - 9.9e-32 106.8 5.9 5.7e-06 25.4 0.0 6.5 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.1 KOO23640.1 - 2.4e-29 101.2 5.5 6e-11 42.3 0.2 5.0 3 1 2 5 5 5 5 EF-hand domain pair EF-hand_8 PF13833.1 KOO23640.1 - 6.4e-20 70.5 5.3 5.5e-08 32.3 0.1 5.9 5 1 1 6 6 6 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO23640.1 - 0.00071 19.5 0.1 2.9 7.9 0.1 3.7 3 2 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region WW PF00397.21 KOO23640.1 - 0.00086 19.1 0.0 0.0018 18.1 0.0 1.6 1 0 0 1 1 1 1 WW domain EF-hand_4 PF12763.2 KOO23640.1 - 0.055 13.2 1.8 5.1 6.8 0.1 3.4 3 1 1 4 4 4 0 Cytoskeletal-regulatory complex EF hand IQ PF00612.22 KOO23640.1 - 0.082 12.5 0.2 0.28 10.9 0.2 2.0 1 0 0 1 1 1 0 IQ calmodulin-binding motif 3HCDH_N PF02737.13 KOO23641.1 - 2.9e-07 30.3 0.0 4.1e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ETF PF01012.16 KOO23643.1 - 0.023 14.4 1.2 0.054 13.2 0.3 2.1 2 0 0 2 2 2 0 Electron transfer flavoprotein domain Cas_Csm6 PF09659.5 KOO23644.1 - 0.065 11.8 0.1 0.092 11.3 0.1 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csm6) EF-hand_1 PF00036.27 KOO23645.1 - 7.7e-12 43.6 1.4 7.1e-06 24.9 0.6 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO23645.1 - 1.6e-09 37.7 0.2 5.7e-09 35.9 0.2 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO23645.1 - 8.6e-09 34.3 0.6 0.0044 16.2 0.3 2.9 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO23645.1 - 2.6e-08 33.3 1.1 1.7e-05 24.3 0.3 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO23645.1 - 1.4e-07 30.7 0.3 0.014 15.1 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 KOO23645.1 - 0.02 14.6 0.1 0.052 13.2 0.1 1.6 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO23645.1 - 0.071 13.1 0.0 0.071 13.1 0.0 2.6 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Borrelia_P83 PF05262.6 KOO23645.1 - 0.15 10.3 24.0 0.28 9.3 16.7 1.4 1 0 0 1 1 1 0 Borrelia P83/100 protein TATR PF03430.8 KOO23645.1 - 6.2 5.3 12.2 9.5 4.7 8.4 1.2 1 0 0 1 1 1 0 Trans-activating transcriptional regulator GAGA_bind PF06217.7 KOO23645.1 - 7.6 6.4 10.7 12 5.7 7.4 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family DUF72 PF01904.13 KOO23646.1 - 6.1e-35 121.0 0.1 7.2e-35 120.8 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF72 U-box PF04564.10 KOO23647.1 - 4.8e-11 42.4 0.0 9.6e-11 41.4 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO23647.1 - 6.9e-05 22.2 0.0 0.00012 21.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Ank_5 PF13857.1 KOO23647.1 - 0.00094 19.3 0.2 0.0027 17.8 0.1 1.8 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO23647.1 - 0.0054 17.0 0.1 0.0091 16.3 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO23647.1 - 0.0093 15.7 1.1 0.016 14.9 0.1 1.9 2 0 0 2 2 2 1 Ankyrin repeat Hint PF01079.15 KOO23648.1 - 1.2e-15 57.3 0.1 1.7e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Hint module Thioesterase PF00975.15 KOO23648.1 - 0.019 15.2 0.0 0.023 14.9 0.0 1.1 1 0 0 1 1 1 0 Thioesterase domain LRR_6 PF13516.1 KOO23649.1 - 3.6e-07 29.5 0.3 0.22 11.7 0.0 3.5 3 0 0 3 3 3 3 Leucine Rich repeat LRR_4 PF12799.2 KOO23649.1 - 0.053 13.1 0.0 0.22 11.2 0.0 2.1 1 1 0 1 1 1 0 Leucine Rich repeats (2 copies) TMCO5 PF14992.1 KOO23649.1 - 0.87 8.6 6.2 1.5 7.8 4.3 1.3 1 0 0 1 1 1 0 TMCO5 family Wbp11 PF09429.5 KOO23649.1 - 1.4 8.9 14.9 9.9 6.2 5.8 2.8 2 1 0 2 2 2 0 WW domain binding protein 11 E1-E2_ATPase PF00122.15 KOO23650.1 - 2.2e-48 164.3 0.1 3.8e-48 163.5 0.1 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 KOO23650.1 - 6.8e-35 121.4 3.3 1.5e-33 117.0 2.3 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO23650.1 - 2.2e-15 57.3 0.0 4.1e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.21 KOO23650.1 - 1.4e-13 50.7 0.0 3.1e-13 49.6 0.0 1.6 1 0 0 1 1 1 1 Heavy-metal-associated domain Hydrolase_3 PF08282.7 KOO23650.1 - 0.00036 20.2 0.3 0.0012 18.5 0.2 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Amidohydro_2 PF04909.9 KOO23651.1 - 3.6e-05 23.4 0.8 0.00015 21.3 0.2 2.2 2 1 0 2 2 2 1 Amidohydrolase GSP_synth PF03738.9 KOO23651.1 - 0.013 15.7 0.1 0.027 14.7 0.1 1.5 1 0 0 1 1 1 0 Glutathionylspermidine synthase preATP-grasp EF-hand_1 PF00036.27 KOO23652.1 - 9.8e-10 37.0 0.6 3.5e-05 22.7 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO23652.1 - 2.4e-09 36.2 1.1 4.8e-05 22.8 0.1 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO23652.1 - 2.3e-06 27.6 0.2 7.1e-06 26.0 0.1 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO23652.1 - 2.2e-05 23.9 0.6 0.00011 21.7 0.1 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO23652.1 - 2.8e-05 23.2 2.0 0.00016 20.8 0.4 2.7 2 0 0 2 2 2 1 EF hand EF-hand_9 PF14658.1 KOO23652.1 - 0.0048 16.7 0.5 0.33 10.8 0.0 2.8 3 0 0 3 3 3 1 EF-hand domain NYD-SP28_assoc PF14775.1 KOO23652.1 - 0.23 11.1 1.9 5.1 6.8 0.3 2.8 2 0 0 2 2 2 0 Sperm tail C-terminal domain DUF3037 PF11236.3 KOO23652.1 - 0.38 10.8 0.1 0.38 10.8 0.0 3.8 2 1 3 5 5 5 0 Protein of unknown function (DUF3037) Podoplanin PF05808.6 KOO23652.1 - 1.4 8.4 5.8 0.39 10.2 0.5 2.3 1 1 1 2 2 2 0 Podoplanin YbjQ_1 PF01906.12 KOO23653.1 - 1.6e-13 51.0 0.1 2.4e-13 50.4 0.1 1.2 1 0 0 1 1 1 1 Putative heavy-metal-binding LRR_6 PF13516.1 KOO23655.1 - 9.2e-10 37.5 0.0 0.0053 16.7 0.0 3.6 3 0 0 3 3 3 3 Leucine Rich repeat LRR_8 PF13855.1 KOO23655.1 - 0.00067 19.3 0.0 0.079 12.7 0.0 3.0 2 1 0 3 3 3 1 Leucine rich repeat LRR_4 PF12799.2 KOO23655.1 - 0.00074 19.0 0.0 0.27 10.8 0.0 2.9 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO23655.1 - 0.043 13.9 0.0 87 4.0 0.0 3.7 3 0 0 3 3 3 0 Leucine rich repeat DUF2924 PF11149.3 KOO23655.1 - 0.18 11.8 0.0 0.43 10.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2924) NMT PF01233.14 KOO23656.1 - 6.2e-21 74.6 0.0 9.6e-21 74.0 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.1 KOO23656.1 - 5.8e-06 26.1 0.0 4.5e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 KOO23656.1 - 2.9e-05 24.1 1.9 0.00023 21.2 0.2 2.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 KOO23656.1 - 0.0029 17.5 1.0 0.006 16.5 0.1 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family NMT_C PF02799.10 KOO23656.1 - 0.005 16.2 0.0 0.0074 15.6 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Acetyltransf_7 PF13508.1 KOO23656.1 - 0.13 12.4 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF3749 PF12568.3 KOO23656.1 - 0.22 11.0 0.9 0.41 10.2 0.6 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain SHIPPO-rpt PF07004.7 KOO23657.1 - 8.9e-08 32.6 31.7 0.0052 17.6 1.7 6.8 7 1 0 7 7 7 4 Sperm-tail PG-rich repeat TPR_11 PF13414.1 KOO23659.1 - 1.7e-76 251.8 40.4 4.8e-17 61.3 1.1 8.3 5 3 1 8 8 8 8 TPR repeat TPR_1 PF00515.23 KOO23659.1 - 6.6e-57 186.9 34.0 8.1e-06 25.2 0.0 12.5 12 0 0 12 12 12 11 Tetratricopeptide repeat TPR_2 PF07719.12 KOO23659.1 - 7e-50 162.9 35.0 5.4e-05 22.7 0.1 12.6 12 0 0 12 12 12 11 Tetratricopeptide repeat TPR_17 PF13431.1 KOO23659.1 - 5.2e-25 85.5 15.9 2.8e-05 23.9 0.3 10.7 11 0 0 11 11 10 5 Tetratricopeptide repeat TPR_14 PF13428.1 KOO23659.1 - 1.3e-24 84.4 33.6 0.0003 21.1 0.0 12.7 5 4 8 13 13 12 7 Tetratricopeptide repeat TPR_16 PF13432.1 KOO23659.1 - 5.4e-21 74.7 29.1 4.8e-05 23.8 0.2 7.6 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.1 KOO23659.1 - 6.8e-18 63.0 26.1 0.00087 18.9 0.0 12.7 12 3 2 14 14 14 3 Tetratricopeptide repeat TPR_9 PF13371.1 KOO23659.1 - 1.5e-17 63.2 24.4 0.00037 20.2 1.9 7.1 5 2 2 7 7 7 6 Tetratricopeptide repeat TPR_19 PF14559.1 KOO23659.1 - 2.1e-16 59.9 25.1 0.00018 21.7 0.7 7.4 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.1 KOO23659.1 - 3.4e-12 46.1 28.1 0.001 18.9 0.0 7.7 4 4 4 8 8 8 5 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO23659.1 - 7.5e-11 41.7 14.0 2.8 7.8 0.0 10.4 9 2 2 11 11 11 2 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.1 KOO23659.1 - 2.4e-09 37.1 8.1 0.099 12.7 0.1 5.5 3 2 1 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO23659.1 - 2.9e-07 29.7 13.9 1.3 8.9 0.0 8.5 9 0 0 9 9 9 2 Tetratricopeptide repeat NARP1 PF12569.3 KOO23659.1 - 2.8e-06 26.3 11.8 0.0084 14.9 0.0 4.8 1 1 3 5 5 5 2 NMDA receptor-regulated protein 1 NDK PF00334.14 KOO23659.1 - 0.00017 21.4 0.0 0.032 14.0 0.0 2.4 2 0 0 2 2 2 1 Nucleoside diphosphate kinase Toxin_13 PF07822.6 KOO23659.1 - 0.0028 17.5 3.8 13 5.7 0.0 4.4 4 0 0 4 4 4 0 Neurotoxin B-IV-like protein SHNi-TPR PF10516.4 KOO23659.1 - 0.0051 16.0 10.5 7.1 5.9 0.0 6.2 7 0 0 7 7 7 1 SHNi-TPR Alkyl_sulf_dimr PF14863.1 KOO23659.1 - 0.02 15.1 15.2 0.29 11.3 0.1 4.9 4 1 1 5 5 4 0 Alkyl sulfatase dimerisation YL1_C PF08265.6 KOO23659.1 - 0.05 13.1 4.6 12 5.5 0.0 4.3 4 0 0 4 4 4 0 YL1 nuclear protein C-terminal domain GPS PF01825.16 KOO23659.1 - 0.15 12.1 0.1 0.36 10.9 0.0 1.6 1 0 0 1 1 1 0 Latrophilin/CL-1-like GPS domain ChAPs PF09295.5 KOO23659.1 - 1.5 7.5 8.7 8.8 4.9 0.3 3.3 3 0 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) Got1 PF04178.7 KOO23661.1 - 6.6e-27 93.9 11.5 1.1e-26 93.2 7.9 1.3 1 0 0 1 1 1 1 Got1/Sft2-like family ISG65-75 PF11727.3 KOO23661.1 - 0.18 10.8 6.5 0.037 13.1 1.3 1.8 2 0 0 2 2 2 0 Invariant surface glycoprotein DUF883 PF05957.8 KOO23661.1 - 6.5 7.2 9.5 8.2 6.9 3.1 3.0 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Nipped-B_C PF12830.2 KOO23662.1 - 6e-12 45.5 0.0 0.00017 21.3 0.0 3.6 2 1 1 3 3 3 2 Sister chromatid cohesion C-terminus PHD PF00628.24 KOO23662.1 - 2.4e-08 33.5 10.1 6.3e-08 32.1 7.0 1.8 1 0 0 1 1 1 1 PHD-finger Cohesin_HEAT PF12765.2 KOO23662.1 - 3.5e-08 33.2 13.4 4.9e-06 26.3 0.9 4.1 3 0 0 3 3 3 2 HEAT repeat associated with sister chromatid cohesion PHD_2 PF13831.1 KOO23662.1 - 0.00036 19.7 5.4 0.00081 18.6 3.8 1.7 1 0 0 1 1 1 1 PHD-finger DUF2435 PF10363.4 KOO23662.1 - 0.00097 18.9 0.8 0.064 13.1 0.0 3.4 3 0 0 3 3 3 1 Protein of unknown function (DUF2435) PLRV_ORF5 PF01690.12 KOO23662.1 - 7.2 5.6 7.9 12 4.8 5.5 1.3 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein p25-alpha PF05517.7 KOO23663.1 - 0.0054 17.0 0.0 0.0068 16.6 0.0 1.3 1 0 0 1 1 1 1 p25-alpha EF-hand_1 PF00036.27 KOO23663.1 - 0.017 14.3 4.3 0.81 9.1 0.0 3.7 3 1 1 4 4 4 0 EF hand EF-hand_7 PF13499.1 KOO23663.1 - 0.025 14.7 3.1 0.17 12.0 1.6 2.5 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.1 KOO23663.1 - 0.58 10.1 6.6 3.8 7.6 0.0 3.8 3 1 1 4 4 4 0 EF-hand domain IQ PF00612.22 KOO23664.1 - 3.4e-06 26.1 1.6 0.024 14.2 0.0 2.7 2 0 0 2 2 2 2 IQ calmodulin-binding motif AA_permease_2 PF13520.1 KOO23665.1 - 7.3e-31 107.1 26.6 1e-30 106.6 18.4 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KOO23665.1 - 9.7e-12 43.9 27.3 2.9e-11 42.4 18.9 1.8 1 1 0 1 1 1 1 Amino acid permease Ufm1 PF03671.9 KOO23666.1 - 6.4e-08 32.2 0.0 1.2e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein AlaDh_PNT_C PF01262.16 KOO23667.1 - 0.00044 19.8 0.0 0.00096 18.7 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.19 KOO23667.1 - 0.0022 16.9 0.4 0.009 14.9 0.3 2.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 KOO23667.1 - 0.0071 16.7 0.3 0.017 15.5 0.2 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 KOO23667.1 - 0.0079 15.2 6.0 0.023 13.7 0.2 3.0 2 1 1 3 3 3 1 FAD binding domain Pyr_redox_2 PF07992.9 KOO23667.1 - 0.011 15.6 0.0 0.082 12.7 0.0 2.2 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 KOO23667.1 - 0.012 14.0 0.2 0.02 13.3 0.2 1.3 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_8 PF13450.1 KOO23667.1 - 0.023 14.7 0.0 0.063 13.3 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 KOO23667.1 - 0.024 13.5 0.4 0.024 13.5 0.3 2.1 2 0 0 2 2 2 0 FAD binding domain Thi4 PF01946.12 KOO23667.1 - 0.071 12.1 0.1 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Thi4 family PDZ_2 PF13180.1 KOO23668.1 - 0.004 17.0 0.0 0.0074 16.1 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.19 KOO23668.1 - 0.0069 16.5 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Tricorn_PDZ PF14685.1 KOO23668.1 - 0.079 12.7 0.0 0.28 10.9 0.0 1.8 2 0 0 2 2 2 0 Tricorn protease PDZ domain zf-CCHH PF10283.4 KOO23669.1 - 0.12 12.2 1.1 3.6 7.5 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger (CX5CX6HX5H) motif TPR_12 PF13424.1 KOO23670.1 - 0.00039 20.2 0.8 0.0016 18.3 0.3 2.1 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO23670.1 - 0.072 13.0 2.5 0.12 12.3 0.2 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 KOO23670.1 - 0.15 11.6 2.1 0.41 10.3 1.0 1.9 1 1 0 1 1 1 0 TPR repeat DUF3726 PF12525.3 KOO23671.1 - 0.045 13.5 0.1 0.17 11.7 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3726) zf-GRF PF06839.7 KOO23672.1 - 0.51 10.3 8.7 0.15 12.0 3.5 2.1 1 1 0 1 1 1 0 GRF zinc finger E1-E2_ATPase PF00122.15 KOO23673.1 - 4.4e-66 222.2 1.7 4.4e-66 222.2 1.2 2.9 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 KOO23673.1 - 5.3e-49 166.2 1.7 1.1e-48 165.1 1.1 1.6 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 KOO23673.1 - 1.4e-31 110.5 0.2 1.7e-30 107.0 0.1 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOO23673.1 - 2.8e-20 72.0 0.0 5.8e-20 71.0 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 KOO23673.1 - 2.4e-19 68.5 4.4 2.8e-19 68.3 0.1 2.8 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 KOO23673.1 - 2.2e-13 50.7 0.0 6e-13 49.3 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 KOO23673.1 - 0.00013 21.6 1.8 0.00029 20.5 0.7 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 KOO23673.1 - 0.046 13.9 0.1 0.49 10.5 0.0 2.5 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase Methyltransf_21 PF05050.7 KOO23674.1 - 8e-06 25.9 0.0 1.6e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase FkbM domain LRR_9 PF14580.1 KOO23675.1 - 9.7e-50 168.5 0.5 1.4e-49 168.0 0.4 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.1 KOO23675.1 - 2.5e-11 43.1 17.8 2.1e-07 30.5 2.9 3.1 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.2 KOO23675.1 - 1.4e-10 40.5 12.7 3.3e-06 26.5 3.9 4.4 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) Abhydrolase_5 PF12695.2 KOO23675.1 - 7.6e-08 32.2 0.0 4e-07 29.8 0.0 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family LRR_1 PF00560.28 KOO23675.1 - 0.00023 20.7 4.8 31 5.1 0.2 5.6 5 0 0 5 5 5 0 Leucine Rich Repeat Abhydrolase_6 PF12697.2 KOO23675.1 - 0.00046 20.1 0.0 0.0011 18.9 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family PhoPQ_related PF10142.4 KOO23675.1 - 0.0016 17.0 0.0 0.0025 16.3 0.0 1.2 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein LRR_7 PF13504.1 KOO23675.1 - 0.017 15.1 10.7 8.8 7.0 0.3 5.8 6 0 0 6 6 6 0 Leucine rich repeat LRR_6 PF13516.1 KOO23675.1 - 0.097 12.7 7.9 92 3.5 0.0 5.6 6 0 0 6 6 6 0 Leucine Rich repeat Pro_CA PF00484.14 KOO23675.1 - 0.17 11.8 0.0 0.42 10.5 0.0 1.7 1 1 0 1 1 1 0 Carbonic anhydrase PALP PF00291.20 KOO23676.1 - 8.1e-49 166.5 2.3 1.8e-48 165.3 1.6 1.6 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Cys_Met_Meta_PP PF01053.15 KOO23676.1 - 4.7e-11 41.6 0.1 2.7e-07 29.2 0.0 2.2 2 0 0 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme RELT PF12606.3 KOO23676.1 - 0.16 11.0 0.0 0.32 10.1 0.0 1.4 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 CAP_N PF01213.14 KOO23678.1 - 1.4e-51 175.6 0.3 1.4e-51 175.6 0.2 2.4 1 1 1 2 2 2 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.6 KOO23678.1 - 1.4e-49 167.4 9.7 2.1e-49 166.9 6.7 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.7 KOO23678.1 - 0.00015 21.1 12.3 0.011 15.1 2.2 2.3 1 1 1 2 2 2 2 Tubulin binding cofactor C Matrilin_ccoil PF10393.4 KOO23678.1 - 0.041 13.2 0.2 0.099 12.0 0.1 1.7 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF3060 PF11259.3 KOO23678.1 - 0.17 11.4 3.6 0.97 9.0 2.4 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3060) YjgF_endoribonc PF14588.1 KOO23679.1 - 2.2e-26 92.5 0.0 2.6e-26 92.3 0.0 1.0 1 0 0 1 1 1 1 YjgF/chorismate_mutase-like, putative endoribonuclease Ribonuc_L-PSP PF01042.16 KOO23679.1 - 2.1e-13 50.1 0.0 3.7e-13 49.3 0.0 1.4 1 1 0 1 1 1 1 Endoribonuclease L-PSP Ldh_2 PF02615.9 KOO23680.1 - 1e-55 188.8 0.2 1.3e-55 188.5 0.1 1.1 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase ABC_tran PF00005.22 KOO23682.1 - 4.3e-42 143.6 0.0 2.9e-20 72.9 0.0 3.1 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 KOO23682.1 - 8.1e-13 48.9 10.5 0.0052 16.7 0.1 4.2 3 1 0 4 4 4 3 AAA domain SMC_N PF02463.14 KOO23682.1 - 1.2e-10 40.9 0.0 0.0063 15.7 0.0 3.3 3 0 0 3 3 3 3 RecF/RecN/SMC N terminal domain TPR_11 PF13414.1 KOO23682.1 - 1.2e-09 37.6 6.3 2.4e-06 27.0 1.0 3.5 3 1 1 4 4 2 2 TPR repeat Nucleotid_trans PF03407.11 KOO23682.1 - 1.6e-08 34.5 0.0 4.9e-08 33.0 0.0 1.8 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase TPR_1 PF00515.23 KOO23682.1 - 1.8e-07 30.4 4.0 0.00074 19.0 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat AAA_25 PF13481.1 KOO23682.1 - 3.5e-07 29.8 0.2 0.0058 16.0 0.1 3.3 3 0 0 3 3 3 2 AAA domain ABC_tran_2 PF12848.2 KOO23682.1 - 1.5e-06 27.9 3.7 1.5e-06 27.9 2.6 4.0 4 0 0 4 4 1 1 ABC transporter NACHT PF05729.7 KOO23682.1 - 1.8e-06 27.7 0.0 0.061 12.9 0.0 2.7 2 0 0 2 2 2 2 NACHT domain AAA_29 PF13555.1 KOO23682.1 - 1.4e-05 24.4 0.3 0.0039 16.6 0.0 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF258 PF03193.11 KOO23682.1 - 3.7e-05 22.9 0.0 0.0004 19.6 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_17 PF13207.1 KOO23682.1 - 0.00017 22.3 1.3 0.17 12.6 0.0 3.3 4 0 0 4 4 3 1 AAA domain TPR_12 PF13424.1 KOO23682.1 - 0.00022 21.0 0.6 0.00022 21.0 0.4 3.0 4 0 0 4 4 1 1 Tetratricopeptide repeat SbcCD_C PF13558.1 KOO23682.1 - 0.00066 19.5 1.6 0.46 10.4 0.0 4.3 4 1 0 4 4 3 1 Putative exonuclease SbcCD, C subunit AAA PF00004.24 KOO23682.1 - 0.00072 19.7 0.1 1.9 8.7 0.0 3.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.1 KOO23682.1 - 0.0014 19.0 16.5 0.12 12.6 0.0 4.3 4 1 0 4 4 3 2 AAA domain TPR_17 PF13431.1 KOO23682.1 - 0.0019 18.2 0.0 1.3 9.4 0.0 3.2 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO23682.1 - 0.0023 18.4 0.1 0.0023 18.4 0.1 5.5 4 2 3 7 7 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO23682.1 - 0.0023 17.6 10.6 0.02 14.7 0.0 4.0 3 0 0 3 3 2 2 Tetratricopeptide repeat AAA_22 PF13401.1 KOO23682.1 - 0.0039 17.3 0.8 0.51 10.4 0.0 3.4 2 2 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 KOO23682.1 - 0.0052 16.9 0.0 0.15 12.2 0.0 2.5 2 0 0 2 2 2 1 RNA helicase AAA_10 PF12846.2 KOO23682.1 - 0.018 14.4 0.6 0.54 9.6 0.1 2.5 2 0 0 2 2 2 0 AAA-like domain AAA_14 PF13173.1 KOO23682.1 - 0.041 13.7 0.0 1.3 8.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.18 KOO23682.1 - 0.055 13.4 0.6 0.19 11.7 0.0 2.2 2 0 0 2 2 2 0 50S ribosome-binding GTPase MobB PF03205.9 KOO23682.1 - 0.07 12.8 0.0 3.9 7.1 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_15 PF13175.1 KOO23682.1 - 0.17 10.9 0.3 48 2.8 0.0 3.4 4 0 0 4 4 4 0 AAA ATPase domain AAA_33 PF13671.1 KOO23682.1 - 0.22 11.4 0.0 0.22 11.4 0.0 3.2 4 0 0 4 4 2 0 AAA domain Dynamin_N PF00350.18 KOO23682.1 - 0.92 9.3 4.5 0.3 10.8 0.1 2.5 3 0 0 3 3 2 0 Dynamin family PIN_3 PF13470.1 KOO23682.1 - 1.9 9.1 9.6 1.1 9.9 0.0 3.8 3 0 0 3 3 3 0 PIN domain Phage_NinH PF06322.6 KOO23683.1 - 0.012 15.2 0.1 0.023 14.2 0.0 1.6 2 0 0 2 2 2 0 Phage NinH protein EF-hand_1 PF00036.27 KOO23684.1 - 5.8e-36 119.0 13.7 6.8e-06 25.0 0.4 6.3 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.1 KOO23684.1 - 1.5e-31 105.3 11.8 5.3e-05 22.7 0.0 6.7 7 0 0 7 7 6 6 EF-hand domain EF-hand_7 PF13499.1 KOO23684.1 - 1.6e-30 104.9 5.9 2.3e-10 40.4 0.1 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO23684.1 - 4.2e-26 90.3 8.5 1.5e-10 40.5 0.1 5.3 3 3 3 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.1 KOO23684.1 - 1.4e-24 84.2 2.2 7.3e-05 21.9 0.0 6.4 6 0 0 6 6 6 4 EF hand SPARC_Ca_bdg PF10591.4 KOO23684.1 - 2.4e-11 43.6 0.5 0.039 13.9 0.0 3.2 3 0 0 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO23684.1 - 6.9e-09 35.2 1.2 0.069 12.8 0.0 3.5 3 0 0 3 3 3 3 EF hand TerB PF05099.8 KOO23684.1 - 9.7e-06 25.3 3.5 0.33 10.6 0.1 3.8 3 2 0 3 3 3 2 Tellurite resistance protein TerB DUF1880 PF08976.6 KOO23684.1 - 9.9e-05 22.4 0.1 5.1 7.2 0.0 3.4 3 0 0 3 3 3 1 Domain of unknown function (DUF1880) Sigma70_r1_1 PF03979.9 KOO23684.1 - 0.00047 20.0 0.0 0.57 10.1 0.0 3.3 3 0 0 3 3 3 1 Sigma-70 factor, region 1.1 PMBR PF09373.5 KOO23684.1 - 0.001 18.9 0.0 16 5.6 0.0 4.4 4 0 0 4 4 4 0 Pseudomurein-binding repeat Toprim PF01751.17 KOO23684.1 - 0.0044 16.9 11.1 1.2 9.1 0.1 4.7 2 2 0 3 3 3 1 Toprim domain EF-hand_4 PF12763.2 KOO23684.1 - 0.0074 16.0 7.1 0.6 9.8 0.2 4.3 3 3 1 4 4 4 1 Cytoskeletal-regulatory complex EF hand Orthopox_F7 PF05813.7 KOO23684.1 - 0.025 14.4 0.9 10 6.0 0.0 3.6 3 1 0 3 3 3 0 Orthopoxvirus F7 protein PP1_inhibitor PF05361.7 KOO23684.1 - 0.038 13.6 3.1 1.7 8.3 0.1 3.4 4 0 0 4 4 4 0 PKC-activated protein phosphatase-1 inhibitor DUF2181 PF10223.4 KOO23684.1 - 0.085 12.2 0.1 8.5 5.6 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2181) Toprim_2 PF13155.1 KOO23684.1 - 1.9 8.8 7.9 21 5.5 0.1 4.3 3 3 1 4 4 4 0 Toprim-like Epimerase PF01370.16 KOO23685.1 - 4.5e-58 196.4 0.1 6e-58 196.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 KOO23685.1 - 8.7e-22 77.3 0.0 6.5e-21 74.4 0.0 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 KOO23685.1 - 1.9e-21 76.0 0.1 2.5e-21 75.6 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 KOO23685.1 - 2.2e-20 72.7 0.0 3e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.7 KOO23685.1 - 4.4e-19 68.3 0.1 7.9e-18 64.2 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.1 KOO23685.1 - 5e-06 26.6 0.0 8.4e-06 25.9 0.0 1.4 1 1 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 KOO23685.1 - 0.0002 20.7 0.2 0.00039 19.7 0.1 1.5 1 1 0 1 1 1 1 NmrA-like family Peripla_BP_6 PF13458.1 KOO23685.1 - 0.039 13.3 0.0 0.062 12.6 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein Tim17 PF02466.14 KOO23686.1 - 8.8e-13 48.4 14.3 1.4e-12 47.7 9.9 1.3 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family TraT PF05818.7 KOO23686.1 - 0.27 10.6 13.2 1.6 8.1 1.4 2.1 1 1 1 2 2 2 0 Enterobacterial TraT complement resistance protein Gly-zipper_Omp PF13488.1 KOO23686.1 - 3.4 7.3 25.7 0.063 12.9 4.4 3.0 2 1 0 2 2 2 0 Glycine zipper Cyt-b5 PF00173.23 KOO23687.1 - 3.1e-08 33.2 0.0 7.2e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain zf-ribbon_3 PF13248.1 KOO23687.1 - 0.058 12.6 0.9 0.12 11.6 0.6 1.6 1 0 0 1 1 1 0 zinc-ribbon domain DZR PF12773.2 KOO23687.1 - 0.24 11.2 0.3 0.51 10.1 0.2 1.5 1 0 0 1 1 1 0 Double zinc ribbon CS PF04969.11 KOO23688.1 - 1.8e-13 50.8 0.0 2.5e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 CS domain DUF3846 PF12957.2 KOO23688.1 - 0.0018 17.9 0.0 0.0038 16.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3846) fn1 PF00039.13 KOO23689.1 - 0.089 12.6 0.5 0.23 11.2 0.4 1.7 1 0 0 1 1 1 0 Fibronectin type I domain Glyco_trans_1_3 PF13528.1 KOO23691.1 - 0.14 11.2 0.0 0.18 10.9 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 1 S4 PF01479.20 KOO23693.1 - 5.5e-10 38.5 0.0 9.5e-10 37.7 0.0 1.4 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.1 KOO23693.1 - 0.0029 17.1 0.0 0.0049 16.4 0.0 1.3 1 0 0 1 1 1 1 S4 domain Nudix_N_2 PF14803.1 KOO23693.1 - 0.0037 16.9 0.3 0.012 15.3 0.2 1.8 1 0 0 1 1 1 1 Nudix N-terminal zinc_ribbon_4 PF13717.1 KOO23693.1 - 0.023 14.4 0.0 0.057 13.1 0.0 1.7 1 0 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 KOO23693.1 - 0.025 14.1 0.0 0.062 12.9 0.0 1.7 1 0 0 1 1 1 0 zinc-ribbon domain APG17 PF04108.7 KOO23694.1 - 0.00075 18.4 7.2 0.0039 16.0 0.1 3.0 2 1 0 3 3 3 2 Autophagy protein Apg17 ChaC PF04752.7 KOO23694.1 - 0.077 12.9 0.2 1.8 8.5 0.0 2.3 2 0 0 2 2 2 0 ChaC-like protein Nol1_Nop2_Fmu PF01189.12 KOO23695.1 - 2.4e-19 69.8 0.1 1.1e-18 67.6 0.1 1.9 1 1 0 1 1 1 1 NOL1/NOP2/sun family EF-hand_1 PF00036.27 KOO23695.1 - 0.00012 21.1 0.0 0.00023 20.2 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.1 KOO23695.1 - 0.00031 19.9 0.0 0.00058 19.0 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO23695.1 - 0.0025 17.9 0.0 0.0044 17.1 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair Methyltransf_18 PF12847.2 KOO23695.1 - 0.0067 16.9 0.1 0.013 16.1 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain EF-hand_6 PF13405.1 KOO23695.1 - 0.009 15.8 0.0 0.022 14.6 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain Methyltransf_26 PF13659.1 KOO23695.1 - 0.034 14.1 1.6 0.096 12.7 1.1 1.9 1 1 0 1 1 1 0 Methyltransferase domain EF-hand_8 PF13833.1 KOO23695.1 - 0.072 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair DnaG_DnaB_bind PF08278.6 KOO23696.1 - 1.6e-07 31.5 9.7 0.086 13.0 0.1 3.1 3 0 0 3 3 3 3 DNA primase DnaG DnaB-binding Caudo_TAP PF02413.12 KOO23696.1 - 0.0002 21.4 12.7 0.6 10.2 0.3 3.1 2 1 1 3 3 3 3 Caudovirales tail fibre assembly protein CsbD PF05532.7 KOO23696.1 - 0.0022 17.6 1.0 3 7.5 0.0 3.3 3 0 0 3 3 3 1 CsbD-like DUF2675 PF11247.3 KOO23696.1 - 0.11 12.6 0.8 11 6.1 0.1 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF2675) Ribosomal_S13 PF00416.17 KOO23696.1 - 0.12 12.7 0.5 8.7 6.8 0.1 2.7 1 1 1 2 2 2 0 Ribosomal protein S13/S18 DUF896 PF05979.7 KOO23696.1 - 0.28 10.8 7.1 7.7 6.1 0.1 3.1 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF896) PspB PF06667.7 KOO23696.1 - 0.82 9.6 6.2 1.7 8.6 0.2 3.2 1 1 3 4 4 4 0 Phage shock protein B Wbp11 PF09429.5 KOO23696.1 - 3.1 7.8 8.4 6.2 6.8 0.7 2.9 2 1 1 3 3 3 0 WW domain binding protein 11 MRFAP1 PF15155.1 KOO23696.1 - 3.4 8.0 9.9 1.2 9.5 1.5 2.3 2 0 0 2 2 2 0 MORF4 family-associated protein1 Exo_endo_phos PF03372.18 KOO23698.1 - 2.3e-15 57.2 0.0 3e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SNF2_N PF00176.18 KOO23699.1 - 1.7e-33 115.7 0.0 1.1e-24 86.8 0.0 2.1 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.26 KOO23699.1 - 5.7e-10 38.9 0.0 9.9e-10 38.1 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOO23699.1 - 0.00047 19.6 0.0 0.00085 18.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.3 KOO23699.1 - 0.0021 16.9 0.0 0.021 13.6 0.0 2.3 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.10 KOO23699.1 - 0.011 15.5 0.0 0.22 11.3 0.0 2.1 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit 2OG-FeII_Oxy_3 PF13640.1 KOO23701.1 - 2.2e-05 24.8 0.0 0.00017 22.0 0.0 2.1 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ShK PF01549.19 KOO23702.1 - 0.00034 20.9 4.3 0.00034 20.9 3.0 2.7 2 1 0 2 2 2 1 ShK domain-like HC2 PF07382.6 KOO23702.1 - 0.0064 16.3 27.5 0.0064 16.3 19.1 3.3 2 1 0 3 3 3 2 Histone H1-like nucleoprotein HC2 Aha1_N PF09229.6 KOO23703.1 - 5e-07 29.6 0.0 7.2e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal DNase_II PF03265.10 KOO23704.1 - 1.7e-57 194.8 0.1 3.2e-57 193.9 0.0 1.4 2 0 0 2 2 2 1 Deoxyribonuclease II DUF4461 PF14688.1 KOO23704.1 - 0.019 14.2 0.1 0.037 13.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4461) Sec63 PF02889.11 KOO23705.1 - 5e-15 55.5 0.0 5.4e-15 55.4 0.0 1.0 1 0 0 1 1 1 1 Sec63 Brl domain Alpha-amyl_C PF09071.5 KOO23705.1 - 0.023 14.4 0.0 0.041 13.6 0.0 1.3 1 0 0 1 1 1 0 Alpha-amylase, C terminal Dynein_heavy PF03028.10 KOO23706.1 - 1.7e-201 670.9 0.0 5.3e-201 669.3 0.0 1.8 2 0 0 2 2 1 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.8 KOO23706.1 - 6.6e-122 406.9 0.2 6.6e-122 406.9 0.1 2.6 2 0 0 2 2 1 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 KOO23706.1 - 2.7e-99 331.3 0.0 8.9e-99 329.6 0.0 2.0 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.2 KOO23706.1 - 3.5e-72 242.6 0.0 8.4e-72 241.3 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 KOO23706.1 - 3e-59 199.6 0.5 8.3e-59 198.1 0.3 1.8 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_7 PF12775.2 KOO23706.1 - 8.4e-46 156.2 0.0 1.7e-45 155.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 MT PF12777.2 KOO23706.1 - 1.2e-44 152.5 19.0 3.5e-44 150.9 12.6 2.1 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.9 KOO23706.1 - 1.4e-20 73.4 0.1 6.7e-05 22.6 0.0 5.6 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOO23706.1 - 3.1e-09 37.0 0.5 0.018 15.0 0.0 5.0 4 0 0 4 4 4 2 AAA ATPase domain AAA PF00004.24 KOO23706.1 - 5.2e-07 29.9 0.7 0.67 10.1 0.0 4.8 5 0 0 5 5 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOO23706.1 - 6.6e-07 29.5 0.1 0.036 14.2 0.0 5.0 4 0 0 4 4 4 1 AAA domain RNA_helicase PF00910.17 KOO23706.1 - 5.2e-06 26.5 0.3 0.092 12.9 0.0 4.4 4 0 0 4 4 3 1 RNA helicase AAA_17 PF13207.1 KOO23706.1 - 0.0011 19.7 0.0 0.39 11.5 0.0 3.8 3 0 0 3 3 2 1 AAA domain T2SE PF00437.15 KOO23706.1 - 0.0013 17.7 1.6 0.082 11.7 0.0 3.5 4 0 0 4 4 4 1 Type II/IV secretion system protein AAA_25 PF13481.1 KOO23706.1 - 0.0015 18.0 1.8 2 7.7 0.0 3.9 3 0 0 3 3 3 1 AAA domain NACHT PF05729.7 KOO23706.1 - 0.0018 17.9 3.4 0.032 13.8 0.0 3.8 4 0 0 4 4 4 1 NACHT domain AAA_10 PF12846.2 KOO23706.1 - 0.0019 17.7 0.5 3.8 6.8 0.0 3.9 3 0 0 3 3 3 1 AAA-like domain UPF0079 PF02367.12 KOO23706.1 - 0.002 17.7 1.4 0.17 11.4 0.0 3.1 3 0 0 3 3 3 1 Uncharacterised P-loop hydrolase UPF0079 Sigma54_activ_2 PF14532.1 KOO23706.1 - 0.0022 18.0 0.5 5.1 7.1 0.0 3.9 4 0 0 4 4 3 1 Sigma-54 interaction domain AAA_19 PF13245.1 KOO23706.1 - 0.0032 17.1 3.8 0.52 10.0 0.2 3.8 4 0 0 4 4 3 1 Part of AAA domain DUF815 PF05673.8 KOO23706.1 - 0.01 14.7 0.0 0.21 10.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.21 KOO23706.1 - 0.018 14.5 0.2 0.12 11.7 0.0 2.5 3 0 0 3 3 2 0 Sigma-54 interaction domain ABC_tran PF00005.22 KOO23706.1 - 0.043 14.1 1.9 1.6 9.0 0.0 4.1 4 0 0 4 4 3 0 ABC transporter AAA_18 PF13238.1 KOO23706.1 - 0.055 13.7 0.0 3.6 7.9 0.0 4.0 4 0 0 4 4 4 0 AAA domain AAA_33 PF13671.1 KOO23706.1 - 0.056 13.3 1.6 8.8 6.2 0.0 4.1 4 0 0 4 4 4 0 AAA domain AAA_29 PF13555.1 KOO23706.1 - 0.1 12.1 0.1 2.3 7.7 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain Mg_chelatase PF01078.16 KOO23706.1 - 0.22 10.6 5.7 0.53 9.4 0.0 3.5 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI DEAD PF00270.24 KOO23707.1 - 1.3e-29 102.9 0.9 2.4e-29 101.9 0.6 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 KOO23707.1 - 4.8e-11 42.8 0.4 1.2e-10 41.4 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 KOO23707.1 - 0.00019 20.3 0.0 0.00029 19.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain AAA_22 PF13401.1 KOO23707.1 - 0.00083 19.5 1.9 0.002 18.2 0.1 2.5 3 1 0 3 3 3 1 AAA domain FtsK_SpoIIIE PF01580.13 KOO23707.1 - 0.011 15.2 0.0 0.026 13.9 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family RsbRD_N PF14361.1 KOO23707.1 - 0.1 13.0 4.7 2.2 8.7 2.6 2.5 2 0 0 2 2 2 0 RsbT co-antagonist protein rsbRD N-terminal domain Sec63 PF02889.11 KOO23708.1 - 9.7e-182 603.1 0.0 1.2e-107 359.7 0.0 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 KOO23708.1 - 2.4e-21 75.9 0.0 7.3e-21 74.3 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO23708.1 - 2.1e-11 43.5 0.0 2.3e-09 37.0 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO23708.1 - 0.005 16.6 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 KOO23708.1 - 0.0096 15.6 0.0 0.078 12.7 0.0 2.6 2 0 0 2 2 2 1 Part of AAA domain AAA_10 PF12846.2 KOO23708.1 - 0.044 13.2 0.0 0.42 10.0 0.0 2.3 2 0 0 2 2 2 0 AAA-like domain AAA_30 PF13604.1 KOO23708.1 - 0.088 12.3 0.0 6.5 6.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain HHH_5 PF14520.1 KOO23708.1 - 0.1 12.8 0.0 0.53 10.5 0.0 2.2 2 0 0 2 2 2 0 Helix-hairpin-helix domain ABC1 PF03109.11 KOO23710.1 - 2e-29 101.9 0.1 3.9e-29 101.0 0.1 1.5 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 KOO23710.1 - 0.0023 17.7 0.9 0.0023 17.7 0.6 4.0 3 1 0 3 3 3 1 Phosphotransferase enzyme family Pkinase PF00069.20 KOO23710.1 - 0.11 11.5 0.0 1.5 7.9 0.0 2.1 2 0 0 2 2 2 0 Protein kinase domain Nop PF01798.13 KOO23711.1 - 2.3e-59 198.9 1.0 4.4e-59 198.0 0.7 1.5 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 KOO23711.1 - 3.6e-28 97.1 0.0 6.7e-28 96.2 0.0 1.5 1 0 0 1 1 1 1 NOSIC (NUC001) domain NOP5NT PF08156.8 KOO23711.1 - 4.7e-19 68.3 0.6 9.9e-19 67.2 0.4 1.6 1 0 0 1 1 1 1 NOP5NT (NUC127) domain DUF3581 PF12119.3 KOO23711.1 - 0.023 13.9 0.0 0.039 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3581) HTH_34 PF13601.1 KOO23711.1 - 0.078 13.0 0.2 12 6.0 0.0 2.8 2 1 0 2 2 2 0 Winged helix DNA-binding domain MCM PF00493.18 KOO23712.1 - 4.1e-122 407.1 4.3 7.1e-112 373.4 0.2 3.2 1 1 1 2 2 2 2 MCM2/3/5 family MCM_N PF14551.1 KOO23712.1 - 1.4e-14 54.5 0.0 3.7e-14 53.2 0.0 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 KOO23712.1 - 2.3e-05 23.6 0.0 7e-05 22.0 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 KOO23712.1 - 0.0015 18.1 0.0 0.0047 16.5 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KOO23712.1 - 0.02 14.5 0.1 0.067 12.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Transaldolase PF00923.14 KOO23713.1 - 3.3e-31 108.4 0.0 1.4e-29 103.1 0.0 2.0 1 1 0 1 1 1 1 Transaldolase LRR_4 PF12799.2 KOO23714.1 - 2.4e-15 55.7 10.7 1.9e-06 27.3 1.8 4.5 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) Zeta_toxin PF06414.7 KOO23714.1 - 7.7e-15 54.5 0.0 2.2e-08 33.4 0.0 2.9 2 0 0 2 2 2 2 Zeta toxin LRR_8 PF13855.1 KOO23714.1 - 1.8e-13 49.9 9.5 2.7e-06 27.0 1.3 3.5 2 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 KOO23714.1 - 6.8e-11 40.6 7.0 0.25 11.4 0.2 7.2 7 0 0 7 7 7 3 Leucine Rich Repeat AAA_33 PF13671.1 KOO23714.1 - 2.8e-06 27.2 0.2 8e-05 22.5 0.0 3.4 3 1 0 3 3 2 1 AAA domain LRR_6 PF13516.1 KOO23714.1 - 2e-05 24.1 8.8 5.9 7.2 0.1 6.6 7 0 0 7 7 7 2 Leucine Rich repeat AAA_17 PF13207.1 KOO23714.1 - 0.00018 22.2 0.2 0.0029 18.4 0.0 3.3 3 0 0 3 3 1 1 AAA domain IQ PF00612.22 KOO23714.1 - 0.0047 16.4 0.3 8.7 6.3 0.0 3.5 3 0 0 3 3 3 0 IQ calmodulin-binding motif AAA_22 PF13401.1 KOO23714.1 - 0.0057 16.7 0.0 0.032 14.3 0.0 2.3 2 0 0 2 2 1 1 AAA domain AAA_14 PF13173.1 KOO23714.1 - 0.0072 16.2 0.0 0.022 14.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOO23714.1 - 0.0095 15.9 10.7 0.028 14.4 0.0 4.1 4 1 0 4 4 4 1 AAA ATPase domain Leucyl-specific PF14795.1 KOO23714.1 - 0.017 14.9 0.1 0.15 11.9 0.1 2.7 1 0 0 1 1 1 0 Leucine-tRNA synthetase-specific domain AAA PF00004.24 KOO23714.1 - 0.021 15.0 0.0 0.21 11.7 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Porin_O_P PF07396.6 KOO23714.1 - 0.056 12.3 2.3 7.6 5.2 0.0 3.3 3 0 0 3 3 3 0 Phosphate-selective porin O and P RNA_helicase PF00910.17 KOO23714.1 - 0.063 13.4 0.0 0.37 10.9 0.0 2.3 2 0 0 2 2 2 0 RNA helicase Arch_ATPase PF01637.13 KOO23714.1 - 0.1 12.2 4.3 0.27 10.8 0.0 2.7 3 0 0 3 3 2 0 Archaeal ATPase LRR_7 PF13504.1 KOO23714.1 - 0.17 12.2 17.3 2.2 8.8 0.2 6.9 7 0 0 7 7 6 0 Leucine rich repeat ABC_tran PF00005.22 KOO23714.1 - 0.46 10.7 0.0 0.46 10.7 0.0 3.4 5 0 0 5 5 3 0 ABC transporter Glyco_transf_29 PF00777.13 KOO23715.1 - 3.5e-07 29.6 0.0 1.4e-06 27.6 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) XRN_N PF03159.13 KOO23716.1 - 3e-20 72.6 0.0 6.8e-17 61.6 0.0 3.2 2 1 0 2 2 2 2 XRN 5'-3' exonuclease N-terminus IBR PF01485.16 KOO23716.1 - 9.8e-13 47.7 28.9 1.5e-08 34.3 2.5 3.3 3 0 0 3 3 3 2 IBR domain Hexapep PF00132.19 KOO23716.1 - 0.33 10.5 2.0 0.71 9.4 1.4 1.4 1 0 0 1 1 1 0 Bacterial transferase hexapeptide (six repeats) EF-hand_7 PF13499.1 KOO23717.1 - 0.00021 21.3 0.0 0.00045 20.2 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO23717.1 - 0.0013 17.9 0.0 0.0031 16.6 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.1 KOO23717.1 - 0.0016 17.6 0.0 0.0042 16.3 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 KOO23717.1 - 0.0047 16.5 0.0 0.01 15.4 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO23717.1 - 0.037 13.8 0.0 0.12 12.2 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain DUF4326 PF14216.1 KOO23718.1 - 0.00018 22.0 0.1 0.0014 19.1 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4326) zf-C2H2_4 PF13894.1 KOO23719.1 - 0.0074 16.5 1.4 0.031 14.6 1.0 2.1 1 0 0 1 1 1 1 C2H2-type zinc finger zf-BED PF02892.10 KOO23719.1 - 0.012 15.3 0.2 0.025 14.3 0.1 1.4 1 0 0 1 1 1 0 BED zinc finger zf-C2H2 PF00096.21 KOO23719.1 - 0.02 15.2 2.0 0.02 15.2 1.4 2.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF3431 PF11913.3 KOO23720.1 - 0.00076 19.0 0.0 0.77 9.1 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3431) DUF2461 PF09365.5 KOO23720.1 - 0.077 12.3 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein (DUF2461) Med7 PF05983.6 KOO23721.1 - 0.15 11.8 0.2 0.32 10.7 0.1 1.6 2 0 0 2 2 2 0 MED7 protein Dendrin PF15498.1 KOO23721.1 - 2.5 6.5 5.9 3.4 6.0 4.1 1.1 1 0 0 1 1 1 0 Nephrin and CD2AP-binding protein, Dendrin DUF2457 PF10446.4 KOO23721.1 - 3.9 6.1 11.4 5 5.7 7.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) IQ PF00612.22 KOO23722.1 - 0.02 14.4 0.9 0.074 12.7 0.6 2.1 1 0 0 1 1 1 0 IQ calmodulin-binding motif Arm PF00514.18 KOO23723.1 - 8.1e-217 694.8 200.8 3.3e-11 42.5 0.0 59.8 62 0 0 62 62 62 47 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO23723.1 - 3.8e-45 152.0 207.0 5.8e-08 32.9 1.5 26.9 9 5 17 29 29 29 26 HEAT repeats V-ATPase_H_N PF03224.9 KOO23723.1 - 5.6e-32 111.1 7.9 0.021 13.9 0.0 14.9 6 3 5 13 13 13 10 V-ATPase subunit H Arm_2 PF04826.8 KOO23723.1 - 6.4e-20 71.3 25.9 0.025 13.6 0.1 17.9 10 5 7 19 19 19 6 Armadillo-like Atx10homo_assoc PF09759.4 KOO23723.1 - 1.3e-14 53.7 13.1 0.015 14.9 0.3 11.6 11 1 1 12 12 12 3 Spinocerebellar ataxia type 10 protein domain KAP PF05804.7 KOO23723.1 - 0.0029 15.6 0.0 0.92 7.3 0.0 4.9 7 1 0 7 7 7 1 Kinesin-associated protein (KAP) V-ATPase_H_C PF11698.3 KOO23723.1 - 0.11 12.4 13.3 2 8.3 0.0 6.3 7 1 1 8 8 8 0 V-ATPase subunit H RYDR_ITPR PF01365.16 KOO23723.1 - 0.16 11.1 0.6 2.3 7.3 0.0 3.2 3 0 0 3 3 3 0 RIH domain N1221 PF07923.8 KOO23723.1 - 0.71 8.6 0.1 2.7e+02 0.1 0.0 4.8 4 0 0 4 4 4 0 N1221-like protein SEN1_N PF12726.2 KOO23723.1 - 3.9 5.3 1.5 23 2.8 0.0 3.0 4 0 0 4 4 4 0 SEN1 N terminal DUF303 PF03629.13 KOO23724.1 - 6.9e-54 182.7 0.0 9e-54 182.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF303) DUF3456 PF11938.3 KOO23725.1 - 0.16 11.9 5.7 0.92 9.4 4.0 2.1 1 1 0 1 1 1 0 TLR4 regulator and MIR-interacting MSAP RNA_lig_T4_1 PF09511.5 KOO23726.1 - 2.2e-13 50.1 0.0 3.3e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 RNA ligase FA_desaturase PF00487.19 KOO23727.1 - 5.5e-35 121.0 27.2 1.5e-33 116.3 18.8 2.1 1 1 0 1 1 1 1 Fatty acid desaturase NAD_binding_8 PF13450.1 KOO23728.1 - 1.3e-15 57.1 0.1 3.6e-15 55.7 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 KOO23728.1 - 2.5e-13 49.8 0.3 3.6e-11 42.8 0.0 3.0 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase DAO PF01266.19 KOO23728.1 - 3.1e-07 29.6 2.1 4.9e-06 25.6 0.2 2.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 KOO23728.1 - 2.7e-06 26.5 3.1 5.7e-06 25.4 0.2 2.6 3 0 0 3 3 3 1 FAD binding domain Thi4 PF01946.12 KOO23728.1 - 4.7e-05 22.5 0.1 0.00012 21.2 0.0 1.6 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.1 KOO23728.1 - 9.4e-05 22.5 0.2 0.0033 17.5 0.1 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 KOO23728.1 - 0.00013 21.7 0.0 0.0017 18.1 0.0 2.5 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_oxidored PF12831.2 KOO23728.1 - 0.00017 20.8 0.1 0.00026 20.2 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 KOO23728.1 - 0.00033 20.6 0.1 0.0022 17.8 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOO23728.1 - 0.0038 17.6 0.1 0.01 16.1 0.1 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 KOO23728.1 - 0.006 15.1 0.2 0.0096 14.4 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.14 KOO23728.1 - 0.01 14.9 0.1 0.016 14.2 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain AlaDh_PNT_C PF01262.16 KOO23728.1 - 0.024 14.2 0.1 0.041 13.4 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Alpha-L-AF_C PF06964.7 KOO23728.1 - 0.026 14.3 0.0 0.059 13.1 0.0 1.5 1 0 0 1 1 1 0 Alpha-L-arabinofuranosidase C-terminus GIDA PF01134.17 KOO23728.1 - 0.035 12.9 0.5 0.066 12.0 0.3 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A ThiF PF00899.16 KOO23728.1 - 0.05 13.4 0.1 3.1 7.6 0.0 2.4 2 0 0 2 2 2 0 ThiF family ApbA PF02558.11 KOO23728.1 - 0.16 11.4 0.8 0.35 10.2 0.2 1.9 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA CMAS PF02353.15 KOO23729.1 - 2.5e-75 253.0 0.2 3.1e-75 252.7 0.2 1.0 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 KOO23729.1 - 1.8e-09 37.4 0.0 3e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO23729.1 - 1.1e-07 32.3 0.0 1.9e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO23729.1 - 7.9e-06 26.2 0.0 2e-05 24.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO23729.1 - 4e-05 24.0 0.0 9.5e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO23729.1 - 0.00041 20.3 0.0 0.00079 19.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO23729.1 - 0.0008 19.0 0.0 0.0022 17.5 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase domain PCMT PF01135.14 KOO23729.1 - 0.0045 16.5 0.1 0.013 15.0 0.0 1.6 1 1 1 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.9 KOO23729.1 - 0.0063 15.9 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain RrnaAD PF00398.15 KOO23729.1 - 0.11 11.4 0.0 0.18 10.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_3 PF01596.12 KOO23729.1 - 0.13 11.3 0.0 0.23 10.4 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase DUF2846 PF11008.3 KOO23730.1 - 0.07 12.9 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2846) BNR PF02012.15 KOO23731.1 - 0.48 10.4 0.2 0.48 10.4 0.2 2.3 2 0 0 2 2 2 0 BNR/Asp-box repeat PARP PF00644.15 KOO23732.1 - 6.5e-21 74.7 0.0 6.4e-18 64.9 0.0 2.2 1 1 1 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain Macro PF01661.16 KOO23732.1 - 1.9e-16 60.0 0.2 4.4e-16 58.8 0.1 1.6 1 0 0 1 1 1 1 Macro domain NYN PF01936.13 KOO23732.1 - 0.066 13.4 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 NYN domain TnpW PF14202.1 KOO23732.1 - 0.3 10.7 0.2 8.5 6.0 0.0 2.9 3 0 0 3 3 3 0 Transposon-encoded protein TnpW cNMP_binding PF00027.24 KOO23734.1 - 0.00017 21.3 0.0 0.00034 20.3 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain APOBEC_N PF08210.6 KOO23735.1 - 5.9e-21 74.9 0.0 8.1e-21 74.4 0.0 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain RRM_1 PF00076.17 KOO23735.1 - 3e-05 23.5 0.0 0.044 13.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO23735.1 - 0.001 19.0 0.0 0.0025 17.7 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Sec63 PF02889.11 KOO23736.1 - 5.2e-125 416.8 0.0 1.1e-60 205.5 0.0 3.2 2 1 1 3 3 3 3 Sec63 Brl domain DEAD PF00270.24 KOO23736.1 - 1.9e-36 125.1 0.0 1.1e-21 77.1 0.0 3.2 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO23736.1 - 3.1e-12 46.1 0.1 3e-05 23.8 0.0 3.1 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.10 KOO23736.1 - 2.2e-09 37.3 0.0 4.4e-07 29.8 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 KOO23736.1 - 1.6e-05 25.0 0.1 0.0041 17.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 KOO23736.1 - 0.0011 17.9 0.0 0.0023 16.9 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein HHH_5 PF14520.1 KOO23736.1 - 0.0092 16.1 1.8 0.016 15.3 0.1 2.3 2 0 0 2 2 1 1 Helix-hairpin-helix domain AAA_19 PF13245.1 KOO23736.1 - 0.042 13.6 0.1 0.13 12.0 0.1 1.8 1 0 0 1 1 1 0 Part of AAA domain AAA_18 PF13238.1 KOO23736.1 - 0.18 12.1 0.0 0.48 10.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 KOO23736.1 - 0.19 11.1 0.0 3.4 7.0 0.0 2.6 2 0 0 2 2 2 0 AAA-like domain SecA_DEAD PF07517.9 KOO23736.1 - 0.23 10.6 0.0 0.62 9.3 0.0 1.6 2 0 0 2 2 2 0 SecA DEAD-like domain Nucleoporin_N PF08801.6 KOO23737.1 - 8.6e-41 140.0 0.0 1.3e-40 139.4 0.0 1.1 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.9 KOO23737.1 - 0.57 8.6 3.7 0.98 7.8 1.7 2.1 2 1 0 2 2 2 0 Non-repetitive/WGA-negative nucleoporin C-terminal DKCLD PF08068.7 KOO23738.1 - 4.9e-31 106.4 0.6 3.2e-30 103.8 0.1 2.5 3 0 0 3 3 3 1 DKCLD (NUC011) domain TruB_N PF01509.13 KOO23738.1 - 1.1e-24 87.3 0.8 6e-22 78.4 0.5 3.2 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.15 KOO23738.1 - 5.6e-20 70.8 2.1 1.1e-19 69.8 1.5 1.5 1 0 0 1 1 1 1 PUA domain YL1 PF05764.8 KOO23738.1 - 2 7.9 16.8 3 7.3 11.6 1.3 1 0 0 1 1 1 0 YL1 nuclear protein SNF2_N PF00176.18 KOO23739.1 - 1.4e-50 171.7 0.0 2.1e-50 171.1 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOO23739.1 - 1.2e-12 47.4 0.0 2.5e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOO23739.1 - 7e-06 25.6 0.0 2.3e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.3 KOO23739.1 - 3.6e-05 22.7 0.0 9.3e-05 21.3 0.0 1.6 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.10 KOO23739.1 - 0.019 14.7 0.0 0.06 13.1 0.0 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_22 PF13401.1 KOO23739.1 - 0.17 11.9 1.3 3 7.9 0.1 3.0 3 1 0 3 3 3 0 AAA domain LRR_6 PF13516.1 KOO23741.1 - 1.5e-14 52.3 11.0 0.0021 17.9 0.1 5.3 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.2 KOO23741.1 - 3e-05 23.5 4.5 0.12 12.0 0.1 3.7 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO23741.1 - 0.00038 20.1 0.7 15 6.0 0.0 4.9 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_8 PF13855.1 KOO23741.1 - 0.012 15.3 4.2 0.42 10.4 0.3 2.9 1 1 1 2 2 2 0 Leucine rich repeat LRR_7 PF13504.1 KOO23741.1 - 0.018 15.1 4.1 65 4.4 0.1 5.2 5 0 0 5 5 5 0 Leucine rich repeat Ank_2 PF12796.2 KOO23742.1 - 1.6e-54 182.2 8.2 4.6e-15 55.7 0.1 3.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 KOO23742.1 - 1.5e-34 116.1 7.6 1.2e-06 28.0 0.1 6.2 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.1 KOO23742.1 - 4.2e-26 90.8 0.3 6.2e-10 39.3 0.0 5.6 4 2 2 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO23742.1 - 5.3e-23 78.7 2.7 6.9e-05 22.7 0.0 6.5 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.1 KOO23742.1 - 1.3e-21 76.1 4.4 2.2e-06 27.7 0.1 6.0 2 1 3 6 6 6 5 Ankyrin repeats (many copies) DUF3647 PF12363.3 KOO23742.1 - 0.1 12.7 0.0 2.2 8.4 0.0 2.2 2 0 0 2 2 2 0 Phage protein Pkinase PF00069.20 KOO23743.1 - 4.2e-52 176.8 0.0 6e-52 176.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO23743.1 - 6.5e-19 68.0 0.0 1e-18 67.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO23743.1 - 0.00013 21.8 2.0 0.00075 19.3 0.0 2.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Herpes_LP PF03363.8 KOO23743.1 - 0.0019 17.7 0.1 0.0037 16.8 0.1 1.4 1 0 0 1 1 1 1 Herpesvirus leader protein Choline_kinase PF01633.15 KOO23743.1 - 0.022 14.3 0.5 0.041 13.4 0.4 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase UPF0564 PF10595.4 KOO23744.1 - 0.0079 15.1 0.4 0.01 14.8 0.3 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0564 CMAS PF02353.15 KOO23745.1 - 3.6e-13 49.2 0.0 5.6e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.2 KOO23745.1 - 1.1e-10 42.0 0.0 1.8e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO23745.1 - 2.6e-09 36.9 0.0 4.3e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO23745.1 - 5.1e-08 32.6 0.0 8.5e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO23745.1 - 9.8e-07 29.1 0.0 1.8e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO23745.1 - 2.4e-06 27.9 0.0 4.5e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOO23745.1 - 2.7e-05 23.6 0.0 4.7e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.12 KOO23745.1 - 6e-05 22.1 0.0 9.6e-05 21.5 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase DUF938 PF06080.7 KOO23745.1 - 0.0025 17.4 0.0 0.0037 16.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Ank_2 PF12796.2 KOO23746.1 - 9.5e-30 102.7 6.0 1.7e-14 53.8 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO23746.1 - 4.1e-28 95.7 11.4 2.1e-08 33.5 0.0 4.9 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.1 KOO23746.1 - 4.7e-22 77.5 6.8 7.5e-09 35.5 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO23746.1 - 4.6e-20 71.6 2.2 2.4e-10 40.6 0.3 3.1 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO23746.1 - 7.9e-16 56.5 5.7 0.0015 18.6 0.0 5.0 4 0 0 4 4 4 4 Ankyrin repeat TPR_11 PF13414.1 KOO23746.1 - 6.1e-15 54.6 7.2 2e-13 49.7 1.6 2.5 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 KOO23746.1 - 2.3e-07 30.1 6.0 0.0009 18.7 0.5 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO23746.1 - 2.3e-07 30.1 9.2 0.004 16.9 0.5 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOO23746.1 - 7e-06 25.8 4.3 1.4e-05 24.9 0.7 2.6 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO23746.1 - 0.00078 19.0 1.4 0.12 12.2 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO23746.1 - 0.0033 17.7 0.4 0.011 16.0 0.3 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO23746.1 - 0.0043 17.6 1.5 0.0043 17.6 1.0 2.9 1 1 1 2 2 2 1 Tetratricopeptide repeat EVC2_like PF12297.3 KOO23746.1 - 0.29 9.6 2.7 0.54 8.8 1.9 1.3 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein TPR_14 PF13428.1 KOO23746.1 - 0.38 11.5 6.2 5.1 8.0 0.2 3.5 2 1 1 3 3 2 0 Tetratricopeptide repeat MgtE PF01769.11 KOO23748.1 - 5e-14 52.7 7.8 6.8e-14 52.3 5.4 1.2 1 0 0 1 1 1 1 Divalent cation transporter HALZ PF02183.13 KOO23748.1 - 0.048 13.3 1.3 0.066 12.9 0.1 1.7 2 0 0 2 2 2 0 Homeobox associated leucine zipper Baculo_gp64 PF03273.8 KOO23748.1 - 0.048 11.8 0.0 0.068 11.3 0.0 1.1 1 0 0 1 1 1 0 Baculovirus gp64 envelope glycoprotein family WD40_alt PF14077.1 KOO23748.1 - 0.087 12.4 0.1 0.17 11.5 0.1 1.4 1 0 0 1 1 1 0 Alternative WD40 repeat motif bZIP_2 PF07716.10 KOO23748.1 - 0.093 12.5 0.6 0.18 11.6 0.4 1.4 1 0 0 1 1 1 0 Basic region leucine zipper Surfac_D-trimer PF09006.6 KOO23748.1 - 0.12 12.0 1.3 0.37 10.5 0.7 1.8 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation WHIM2 PF15613.1 KOO23750.1 - 0.097 12.6 0.2 0.2 11.6 0.1 1.5 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 2 Borrelia_P83 PF05262.6 KOO23750.1 - 1.3 7.1 11.1 2 6.5 7.7 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein PSD2 PF07624.6 KOO23751.1 - 0.087 12.4 0.1 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1585) SCHIP-1 PF10148.4 KOO23752.1 - 0.007 15.7 0.2 0.0081 15.5 0.2 1.1 1 0 0 1 1 1 1 Schwannomin-interacting protein 1 FEZ PF07763.8 KOO23752.1 - 0.051 13.2 0.2 0.056 13.1 0.1 1.0 1 0 0 1 1 1 0 FEZ-like protein zf-CCHC PF00098.18 KOO23753.1 - 4.8e-08 32.5 17.3 0.00078 19.2 2.3 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.1 KOO23753.1 - 0.059 13.0 1.3 0.059 13.0 0.9 2.8 2 1 1 3 3 3 0 Zinc knuckle DUF702 PF05142.7 KOO23753.1 - 0.27 11.4 13.4 0.043 13.9 6.7 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF702) zf-CCHC_2 PF13696.1 KOO23753.1 - 2.7 7.5 12.7 0.3 10.6 1.8 2.6 2 1 1 3 3 3 0 Zinc knuckle YyzF PF14116.1 KOO23753.1 - 2.9 7.9 5.4 13 5.8 0.4 2.6 1 1 1 2 2 2 0 YyzF-like protein zf-CCHC_3 PF13917.1 KOO23753.1 - 3.1 7.6 15.1 0.075 12.7 4.8 2.4 1 1 1 2 2 2 0 Zinc knuckle Proteasome PF00227.21 KOO23754.1 - 5.1e-45 153.1 0.0 7e-45 152.6 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 KOO23754.1 - 4.6e-15 54.6 0.5 7.8e-15 53.8 0.4 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Pkinase PF00069.20 KOO23755.1 - 2.3e-71 240.0 0.0 3e-71 239.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO23755.1 - 3.5e-43 147.5 0.0 5.4e-43 146.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Arm PF00514.18 KOO23755.1 - 6.5e-06 25.7 2.0 0.00012 21.7 0.1 3.6 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat Kinase-like PF14531.1 KOO23755.1 - 3.7e-05 22.8 0.0 5.5e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like HEAT PF02985.17 KOO23755.1 - 0.0091 15.9 0.2 0.57 10.4 0.0 3.9 4 0 0 4 4 4 1 HEAT repeat RIO1 PF01163.17 KOO23755.1 - 0.032 13.5 0.1 0.051 12.9 0.1 1.2 1 0 0 1 1 1 0 RIO1 family HEAT_2 PF13646.1 KOO23755.1 - 0.048 13.9 16.1 1 9.6 2.4 4.7 4 1 0 4 4 4 0 HEAT repeats Kdo PF06293.9 KOO23755.1 - 0.21 10.6 0.0 0.36 9.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Rho_GDI PF02115.12 KOO23756.1 - 0.0012 18.2 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor BATS PF06968.8 KOO23757.1 - 2e-24 85.2 0.0 4.9e-24 83.9 0.0 1.7 1 0 0 1 1 1 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.16 KOO23757.1 - 1.2e-13 51.5 0.2 2.1e-13 50.7 0.1 1.4 1 0 0 1 1 1 1 Radical SAM superfamily PhyH PF05721.8 KOO23759.1 - 1.7e-23 83.8 0.0 3.2e-23 82.8 0.0 1.5 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_3 PF13640.1 KOO23759.1 - 2.6e-06 27.8 0.0 5.8e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily HD PF01966.17 KOO23759.1 - 6.5e-05 22.9 0.4 0.0019 18.1 0.3 2.3 2 0 0 2 2 2 1 HD domain 2OG-FeII_Oxy_5 PF13759.1 KOO23759.1 - 0.0006 20.0 0.0 0.0027 17.9 0.0 2.0 2 0 0 2 2 2 1 Putative 2OG-Fe(II) oxygenase DUF706 PF05153.10 KOO23759.1 - 0.0075 15.6 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF706) fn3 PF00041.16 KOO23760.1 - 6.3e-62 205.6 29.5 2.1e-07 30.9 0.1 13.8 15 2 0 15 15 15 10 Fibronectin type III domain YIEGIA PF14045.1 KOO23760.1 - 0.28 9.7 0.0 0.43 9.1 0.0 1.2 1 0 0 1 1 1 0 YIEGIA protein Arf PF00025.16 KOO23761.1 - 1.9e-31 108.6 0.0 2.4e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 KOO23761.1 - 1.9e-07 31.6 0.0 2.8e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 KOO23761.1 - 2e-07 30.6 0.0 1.2e-06 28.0 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.5 KOO23761.1 - 6.3e-07 28.7 0.0 8.8e-07 28.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 KOO23761.1 - 3.4e-06 26.3 0.0 4.3e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.17 KOO23761.1 - 0.0001 21.7 0.0 0.00018 20.9 0.0 1.4 1 1 0 1 1 1 1 Ras family MMR_HSR1 PF01926.18 KOO23761.1 - 0.00079 19.3 0.0 0.0013 18.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_25 PF13481.1 KOO23761.1 - 0.013 14.8 0.4 0.02 14.2 0.3 1.4 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.15 KOO23761.1 - 0.038 12.6 0.0 0.15 10.7 0.0 1.8 2 0 0 2 2 2 0 G-protein alpha subunit adh_short PF00106.20 KOO23762.1 - 9.7e-14 51.6 5.7 9.7e-14 51.6 3.9 1.7 1 1 1 2 2 2 1 short chain dehydrogenase KR PF08659.5 KOO23762.1 - 3.1e-07 30.2 3.1 6.3e-07 29.2 1.9 1.7 1 1 1 2 2 2 1 KR domain adh_short_C2 PF13561.1 KOO23762.1 - 0.0015 18.3 0.0 0.0024 17.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase EF-hand_7 PF13499.1 KOO23763.1 - 7.5e-13 48.4 0.2 4.1e-11 42.8 0.1 2.4 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO23763.1 - 2.5e-12 45.5 2.0 0.00023 20.7 0.0 4.1 3 1 1 4 4 4 2 EF-hand domain EF-hand_1 PF00036.27 KOO23763.1 - 3.1e-12 44.8 1.3 8.5e-05 21.5 0.1 3.3 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.1 KOO23763.1 - 2.5e-11 42.3 6.8 1.1e-06 27.7 0.0 3.0 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO23763.1 - 5.8e-08 32.2 3.1 1.9e-06 27.3 0.1 3.4 2 2 1 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO23763.1 - 0.0013 18.7 0.1 0.0027 17.6 0.1 1.6 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO23763.1 - 0.014 15.0 0.0 0.031 13.9 0.0 1.6 1 0 0 1 1 1 0 EF hand EF-hand_4 PF12763.2 KOO23763.1 - 0.073 12.8 0.1 0.44 10.3 0.0 2.2 2 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand DnaJ PF00226.26 KOO23766.1 - 0.14 11.9 1.0 0.56 9.9 0.7 2.2 1 1 0 1 1 1 0 DnaJ domain UPF0560 PF10577.4 KOO23766.1 - 0.21 9.8 8.0 0.24 9.5 5.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Atg14 PF10186.4 KOO23766.1 - 1.8 7.3 14.0 2.5 6.9 9.7 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 IncA PF04156.9 KOO23766.1 - 2.9 7.4 10.5 4.2 6.9 7.3 1.3 1 0 0 1 1 1 0 IncA protein Asp-B-Hydro_N PF05279.6 KOO23766.1 - 3.8 7.3 12.4 5.1 6.8 8.6 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4407 PF14362.1 KOO23766.1 - 9 5.1 13.3 12 4.6 9.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Peptidase_M16 PF00675.15 KOO23767.1 - 1.8e-38 131.6 0.0 2.9e-34 117.9 0.0 3.6 3 1 1 4 4 4 2 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 KOO23767.1 - 1.1e-32 113.1 0.0 9.1e-14 51.5 0.0 3.4 3 0 0 3 3 3 3 Peptidase M16 inactive domain BESS PF02944.15 KOO23767.1 - 0.1 12.1 0.1 0.21 11.1 0.0 1.6 1 0 0 1 1 1 0 BESS motif DUF1145 PF06611.7 KOO23770.1 - 0.036 13.7 1.3 0.036 13.7 0.9 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1145) DUF1564 PF07600.6 KOO23770.1 - 0.092 12.0 0.2 0.13 11.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1564) DUF46 PF01864.12 KOO23770.1 - 0.21 11.4 5.2 0.26 11.1 3.6 1.1 1 0 0 1 1 1 0 Putative integral membrane protein DUF46 Ribosomal_L2_C PF03947.13 KOO23771.1 - 6.7e-51 171.4 0.2 1e-50 170.8 0.2 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 KOO23771.1 - 1.1e-23 82.9 0.0 3.1e-23 81.5 0.1 1.8 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain EF-hand_1 PF00036.27 KOO23772.1 - 5.6e-20 69.0 2.1 9.7e-06 24.5 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 KOO23772.1 - 2.3e-19 67.4 0.7 1.1e-05 24.9 0.0 4.3 5 0 0 5 5 5 3 EF-hand domain EF-hand_7 PF13499.1 KOO23772.1 - 1.7e-18 66.4 2.2 8.9e-10 38.5 0.1 3.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO23772.1 - 1.3e-16 59.0 5.5 1.5e-05 24.1 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 KOO23772.1 - 9.1e-13 47.6 0.9 5.3e-08 32.3 0.1 3.7 2 1 1 3 3 3 3 EF-hand domain pair Barstar PF01337.13 KOO23772.1 - 0.044 13.6 0.1 0.33 10.8 0.0 2.5 2 0 0 2 2 2 0 Barstar (barnase inhibitor) Dockerin_1 PF00404.13 KOO23772.1 - 4 7.3 8.5 20 5.0 0.2 3.6 3 0 0 3 3 3 0 Dockerin type I repeat Kinesin PF00225.18 KOO23774.1 - 3.8e-54 183.6 0.0 3.2e-34 118.1 0.0 2.1 1 1 1 2 2 2 2 Kinesin motor domain bZIP_2 PF07716.10 KOO23774.1 - 0.023 14.5 1.7 0.028 14.2 0.2 1.9 2 0 0 2 2 2 0 Basic region leucine zipper MAD PF05557.8 KOO23774.1 - 0.028 12.5 0.0 0.042 11.9 0.0 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein DUF2630 PF10944.3 KOO23774.1 - 0.095 12.8 1.5 28 4.9 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2630) Cep57_CLD_2 PF14197.1 KOO23774.1 - 0.87 9.5 3.6 4.2 7.3 0.2 2.5 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 CLP_protease PF00574.18 KOO23775.1 - 5.8e-76 254.2 1.3 7.1e-76 253.9 0.9 1.0 1 0 0 1 1 1 1 Clp protease PMP22_Claudin PF00822.15 KOO23776.1 - 0.00067 19.3 0.2 0.00067 19.3 0.1 1.0 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family VMA21 PF09446.5 KOO23776.1 - 0.0015 18.4 6.0 0.0017 18.2 4.1 1.1 1 0 0 1 1 1 1 VMA21-like domain RseC_MucC PF04246.7 KOO23776.1 - 0.18 11.3 0.6 0.19 11.2 0.4 1.1 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC DsbD_2 PF13386.1 KOO23776.1 - 0.87 9.2 3.7 1.1 9.0 2.5 1.2 1 0 0 1 1 1 0 Cytochrome C biogenesis protein transmembrane region DUF940 PF06082.6 KOO23777.1 - 0.078 11.5 1.9 0.1 11.1 1.3 1.1 1 0 0 1 1 1 0 Bacterial putative lipoprotein (DUF940) Acyltransferase PF01553.16 KOO23778.1 - 1.4e-09 37.4 0.0 2.7e-08 33.3 0.0 2.3 1 1 0 1 1 1 1 Acyltransferase C2 PF00168.25 KOO23779.1 - 6.1e-09 35.6 0.0 7e-08 32.2 0.0 2.3 2 0 0 2 2 2 1 C2 domain Ion_trans PF00520.26 KOO23779.1 - 1.8e-08 33.8 0.0 4.2e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.24 KOO23779.1 - 0.0033 17.2 0.0 0.0062 16.3 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain DUF1754 PF08555.5 KOO23780.1 - 0.027 15.0 0.8 0.095 13.3 0.0 2.0 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) Ion_trans PF00520.26 KOO23783.1 - 1.7e-138 458.3 50.2 9.6e-40 135.9 2.9 4.2 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 KOO23783.1 - 1.3e-08 33.6 49.7 7.3e-05 21.3 4.0 7.3 5 3 2 7 7 7 5 Polycystin cation channel DUF1628 PF07790.6 KOO23783.1 - 0.079 13.7 0.6 12 6.7 0.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1628) FAM176 PF14851.1 KOO23783.1 - 0.25 10.9 0.0 2.5 7.7 0.0 2.5 3 0 0 3 3 3 0 FAM176 family ketoacyl-synt PF00109.21 KOO23785.1 - 1.5e-54 185.1 0.1 1.5e-54 185.1 0.1 2.7 3 0 0 3 3 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 KOO23785.1 - 8.4e-39 133.7 0.0 1.7e-38 132.7 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.17 KOO23785.1 - 2.8e-35 120.7 6.3 1e-34 118.9 3.7 2.6 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain AMP-binding PF00501.23 KOO23785.1 - 1e-31 109.8 0.0 1.8e-31 109.0 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme KR PF08659.5 KOO23785.1 - 1.7e-28 99.5 1.2 6.4e-28 97.6 0.0 2.8 3 0 0 3 3 3 1 KR domain adh_short PF00106.20 KOO23785.1 - 5.8e-26 91.3 0.1 5.8e-26 91.3 0.1 3.2 4 0 0 4 4 2 1 short chain dehydrogenase PP-binding PF00550.20 KOO23785.1 - 1e-21 76.9 0.3 8.5e-12 45.1 0.0 2.6 2 0 0 2 2 2 2 Phosphopantetheine attachment site Thioesterase PF00975.15 KOO23785.1 - 2.3e-15 57.4 2.9 8.1e-12 45.8 0.5 2.7 2 0 0 2 2 2 2 Thioesterase domain Abhydrolase_5 PF12695.2 KOO23785.1 - 9.9e-09 35.0 3.6 8.6e-06 25.5 0.5 3.0 2 0 0 2 2 2 2 Alpha/beta hydrolase family Epimerase PF01370.16 KOO23785.1 - 5.9e-05 22.6 0.0 0.0001 21.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Abhydrolase_1 PF00561.15 KOO23785.1 - 0.00025 20.6 1.0 0.0015 18.1 0.0 2.4 2 1 0 3 3 3 1 alpha/beta hydrolase fold Thiolase_N PF00108.18 KOO23785.1 - 0.00086 18.3 0.7 0.0017 17.3 0.5 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain AMP-binding_C PF13193.1 KOO23785.1 - 0.015 16.2 0.6 0.13 13.2 0.1 3.0 3 0 0 3 3 1 0 AMP-binding enzyme C-terminal domain 3Beta_HSD PF01073.14 KOO23785.1 - 0.21 10.2 0.0 0.31 9.6 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family PGAP1 PF07819.8 KOO23785.1 - 1.2 8.6 0.0 2.4 7.6 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Hanta_nucleocap PF00846.13 KOO23785.1 - 2.4 6.7 0.0 41 2.7 0.0 2.1 2 0 0 2 2 2 0 Hantavirus nucleocapsid protein Glyco_hydro_1 PF00232.13 KOO23786.1 - 5.6e-151 502.7 0.0 7e-151 502.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 TPR_11 PF13414.1 KOO23787.1 - 0.0019 17.7 0.4 0.72 9.5 0.0 2.4 2 0 0 2 2 2 2 TPR repeat TPR_16 PF13432.1 KOO23787.1 - 0.029 15.0 0.1 0.029 15.0 0.1 2.8 3 1 0 3 3 3 0 Tetratricopeptide repeat ADP_ribosyl_GH PF03747.9 KOO23787.1 - 0.11 12.3 0.1 0.95 9.1 0.0 1.9 2 0 0 2 2 2 0 ADP-ribosylglycohydrolase TPR_14 PF13428.1 KOO23787.1 - 7.1 7.5 7.3 0.65 10.7 0.5 2.7 3 1 0 3 3 3 0 Tetratricopeptide repeat LRR_8 PF13855.1 KOO23788.1 - 0.00022 20.9 0.4 0.0005 19.7 0.3 1.6 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.2 KOO23788.1 - 0.0027 17.2 0.3 0.15 11.7 0.0 2.4 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) FGGY_C PF02782.11 KOO23789.1 - 1.8e-29 102.7 4.1 2.6e-29 102.2 2.8 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 KOO23789.1 - 0.0006 19.2 0.0 0.0025 17.1 0.0 1.9 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain RHH_1 PF01402.16 KOO23789.1 - 0.093 12.6 0.1 14 5.8 0.1 2.6 2 0 0 2 2 2 0 Ribbon-helix-helix protein, copG family DEAD PF00270.24 KOO23790.1 - 1.6e-43 148.1 0.0 1.1e-42 145.4 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO23790.1 - 6.2e-25 86.8 0.0 1.7e-24 85.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RRM_5 PF13893.1 KOO23790.1 - 0.00025 20.8 0.1 0.00098 18.9 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SNF2_N PF00176.18 KOO23790.1 - 0.00044 19.1 0.0 0.00076 18.3 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain RRM_1 PF00076.17 KOO23790.1 - 0.00047 19.7 0.1 0.0016 17.9 0.1 2.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO23790.1 - 0.016 15.2 0.0 0.056 13.4 0.0 2.0 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) ResIII PF04851.10 KOO23790.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Ras PF00071.17 KOO23793.1 - 6.4e-61 204.4 0.0 7.7e-61 204.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO23793.1 - 7.7e-21 74.7 0.0 1.1e-20 74.3 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO23793.1 - 8.7e-13 47.8 0.0 1e-12 47.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KOO23793.1 - 2.9e-05 23.3 0.0 3.5e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 KOO23793.1 - 9.3e-05 22.3 0.0 0.00013 21.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 KOO23793.1 - 0.0007 19.0 0.0 0.0014 18.0 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 KOO23793.1 - 0.089 11.9 0.1 0.17 11.0 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function, DUF258 Plus-3 PF03126.13 KOO23794.1 - 7.3e-08 32.4 0.0 1.9e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 Plus-3 domain BAH PF01426.13 KOO23794.1 - 9.3e-07 28.6 0.0 2.6e-06 27.1 0.0 1.8 1 1 0 1 1 1 1 BAH domain RNA_pol_Rpc4 PF05132.9 KOO23794.1 - 0.61 10.0 7.3 0.2 11.6 0.1 2.5 2 0 0 2 2 2 0 RNA polymerase III RPC4 TPR_1 PF00515.23 KOO23795.1 - 2.6e-46 153.3 6.2 2.6e-08 33.1 0.1 7.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_11 PF13414.1 KOO23795.1 - 3.7e-39 132.1 18.3 8.4e-12 44.5 1.5 5.5 2 1 3 6 6 6 5 TPR repeat TPR_2 PF07719.12 KOO23795.1 - 3.6e-36 120.1 13.5 7.4e-06 25.4 0.1 7.9 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.1 KOO23795.1 - 3.1e-32 107.9 1.9 1.2e-06 27.8 0.0 7.5 6 1 1 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.1 KOO23795.1 - 3.9e-27 92.1 7.6 0.00053 19.9 0.0 7.3 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.1 KOO23795.1 - 3.2e-26 91.0 9.9 5.8e-08 32.5 0.1 5.7 2 2 3 5 5 5 5 Tetratricopeptide repeat TPR_19 PF14559.1 KOO23795.1 - 2.3e-23 82.2 6.9 9.9e-10 38.6 0.1 5.4 4 2 1 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.1 KOO23795.1 - 3.6e-23 81.6 6.4 3.6e-07 30.6 0.0 5.9 1 1 5 7 7 7 6 Tetratricopeptide repeat TPR_14 PF13428.1 KOO23795.1 - 3.2e-22 77.0 5.1 0.0049 17.3 0.0 7.7 3 1 5 8 8 7 6 Tetratricopeptide repeat TPR_7 PF13176.1 KOO23795.1 - 1.2e-16 59.0 7.0 0.00067 19.2 0.0 7.3 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_9 PF13371.1 KOO23795.1 - 3.9e-16 58.6 1.4 0.00011 21.9 0.0 5.4 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOO23795.1 - 3.2e-13 49.1 11.3 0.028 14.8 0.0 7.8 8 0 0 8 8 7 3 Tetratricopeptide repeat Apc3 PF12895.2 KOO23795.1 - 8.6e-10 38.6 15.0 0.00021 21.3 0.1 4.7 1 1 4 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 ChAPs PF09295.5 KOO23795.1 - 2.8e-08 32.9 1.0 2e-05 23.5 0.1 2.5 1 1 1 3 3 3 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_10 PF13374.1 KOO23795.1 - 3e-08 33.3 7.8 12 6.0 0.0 7.7 7 1 1 8 8 8 0 Tetratricopeptide repeat TPR_15 PF13429.1 KOO23795.1 - 2.5e-07 30.0 1.3 0.031 13.3 0.0 3.3 1 1 1 2 2 2 2 Tetratricopeptide repeat NARP1 PF12569.3 KOO23795.1 - 3.2e-06 26.1 1.1 0.11 11.1 0.0 3.3 2 1 1 3 3 3 2 NMDA receptor-regulated protein 1 Fis1_TPR_C PF14853.1 KOO23795.1 - 5.3e-06 26.2 2.6 1.9 8.4 0.0 5.4 6 0 0 6 6 5 2 Fis1 C-terminal tetratricopeptide repeat TPR_21 PF09976.4 KOO23795.1 - 2.9e-05 24.0 0.9 0.0057 16.6 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat FAT PF02259.18 KOO23795.1 - 0.00064 18.8 2.2 0.14 11.0 0.2 2.7 1 1 1 2 2 2 2 FAT domain Coatomer_E PF04733.9 KOO23795.1 - 0.0007 18.8 1.4 0.092 11.9 0.0 3.3 2 1 1 3 3 3 1 Coatomer epsilon subunit TPR_20 PF14561.1 KOO23795.1 - 0.00089 19.3 3.4 0.0041 17.2 0.3 3.2 2 1 2 4 4 4 1 Tetratricopeptide repeat PPTA PF01239.17 KOO23795.1 - 0.0026 17.0 0.1 19 4.8 0.0 3.8 3 0 0 3 3 3 0 Protein prenyltransferase alpha subunit repeat DUF2225 PF09986.4 KOO23795.1 - 0.031 13.7 4.1 0.51 9.7 0.1 3.3 1 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) Alkyl_sulf_dimr PF14863.1 KOO23795.1 - 0.044 13.9 0.1 0.65 10.2 0.0 2.4 1 1 1 2 2 2 0 Alkyl sulfatase dimerisation DUF3327 PF11806.3 KOO23795.1 - 0.091 13.0 0.2 4.6 7.5 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3327) Rapsyn_N PF10579.4 KOO23795.1 - 0.11 12.3 0.3 6.2 6.6 0.0 3.3 3 1 1 4 4 4 0 Rapsyn N-terminal myristoylation and linker region Baculo_PEP_C PF04513.7 KOO23796.1 - 0.028 14.2 5.1 0.067 13.0 0.0 3.1 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus ADIP PF11559.3 KOO23796.1 - 1 9.2 16.3 3 7.7 7.3 3.1 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding APG6 PF04111.7 KOO23796.1 - 1.4 7.8 15.2 11 5.0 7.3 2.4 2 1 0 2 2 2 0 Autophagy protein Apg6 Bcr-Abl_Oligo PF09036.5 KOO23796.1 - 2.7 7.9 6.3 1.1 9.3 0.1 3.1 3 1 0 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain Glyco_hydro_31 PF01055.21 KOO23797.1 - 1.3e-25 90.1 7.6 7.6e-24 84.3 5.3 2.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 PAP_assoc PF03828.14 KOO23798.1 - 6.7e-19 67.5 0.1 1.3e-18 66.7 0.1 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 KOO23798.1 - 0.051 13.8 0.0 0.097 13.0 0.0 1.5 1 0 0 1 1 1 0 Nucleotidyltransferase domain tRNA_Me_trans PF03054.11 KOO23799.1 - 7.6e-108 360.2 0.0 8.8e-108 360.0 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase Asn_synthase PF00733.16 KOO23799.1 - 0.0012 18.3 0.0 0.002 17.6 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase ThiI PF02568.9 KOO23799.1 - 0.0015 17.9 0.0 0.0023 17.4 0.0 1.3 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) DUF1448 PF07289.6 KOO23800.1 - 9.1e-136 452.2 0.2 1.1e-135 451.9 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1448) Voldacs PF03517.8 KOO23800.1 - 8.8e-05 22.3 0.0 0.31 10.8 0.0 2.6 2 1 0 2 2 2 2 Regulator of volume decrease after cellular swelling Vps36_ESCRT-II PF11605.3 KOO23800.1 - 0.003 17.3 0.0 0.24 11.2 0.0 2.4 2 0 0 2 2 2 1 Vacuolar protein sorting protein 36 Vps36 His_Phos_1 PF00300.17 KOO23801.1 - 3.6e-12 46.6 0.0 4.4e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Peptidase_S10 PF00450.17 KOO23802.1 - 3.1e-81 273.6 0.0 4.4e-81 273.1 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase EF-hand_1 PF00036.27 KOO23802.1 - 1.7e-09 36.3 0.0 0.0015 17.6 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO23802.1 - 7.8e-09 35.0 0.0 2.1e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO23802.1 - 2e-08 33.2 0.2 0.0017 17.5 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO23802.1 - 3.1e-08 33.6 0.0 6.3e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO23802.1 - 8.5e-08 31.4 0.0 0.0012 18.5 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain GST_C PF00043.20 KOO23805.1 - 3.6e-10 39.6 0.0 6e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 KOO23805.1 - 6e-07 29.5 0.0 1.3e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 KOO23805.1 - 9.6e-06 25.7 0.0 2.4e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 KOO23805.1 - 1.4e-05 25.4 0.0 2.7e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 KOO23805.1 - 1.5e-05 24.8 0.0 4.1e-05 23.3 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 KOO23805.1 - 0.00076 19.4 0.0 0.0014 18.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain E1_dh PF00676.15 KOO23806.1 - 5.3e-83 278.1 0.0 7e-83 277.7 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.16 KOO23806.1 - 0.00052 19.6 0.1 0.0036 16.9 0.1 2.1 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Laminin_G_3 PF13385.1 KOO23807.1 - 5e-26 91.8 0.0 1.2e-25 90.5 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Kelch_4 PF13418.1 KOO23807.1 - 7.7e-26 89.6 0.7 9.9e-05 22.0 0.0 5.9 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.1 KOO23807.1 - 5.2e-24 83.7 4.0 8.9e-08 32.0 0.1 5.2 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.1 KOO23807.1 - 1.2e-22 79.0 1.0 1.5e-06 28.1 0.0 6.4 4 2 2 6 6 6 5 Kelch motif Kelch_5 PF13854.1 KOO23807.1 - 8.3e-19 67.1 1.7 0.00049 19.9 0.0 5.0 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.20 KOO23807.1 - 3.2e-18 64.9 0.0 0.0002 20.8 0.0 5.4 5 0 0 5 5 5 4 Kelch motif Filamin PF00630.14 KOO23807.1 - 3.4e-17 62.8 0.0 6.7e-17 61.9 0.0 1.5 1 0 0 1 1 1 1 Filamin/ABP280 repeat Kelch_2 PF07646.10 KOO23807.1 - 4.8e-15 54.6 2.4 0.066 13.0 0.0 6.4 6 1 0 6 6 6 5 Kelch motif PUB PF09409.5 KOO23808.1 - 3.7e-13 49.0 0.0 6.2e-13 48.3 0.0 1.4 1 0 0 1 1 1 1 PUB domain UBX PF00789.15 KOO23808.1 - 1.1e-09 38.1 0.0 2e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 UBX domain ThiS PF02597.15 KOO23808.1 - 0.042 14.2 0.6 0.48 10.8 0.0 2.7 3 0 0 3 3 3 0 ThiS family Cytochrom_C1 PF02167.10 KOO23809.1 - 9.8e-65 218.2 0.0 1.1e-64 218.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome C1 family DUF1295 PF06966.7 KOO23810.1 - 3.7e-22 78.7 0.2 5.1e-22 78.3 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.8 KOO23810.1 - 0.00031 20.8 0.9 0.0011 19.0 0.1 2.1 1 1 1 2 2 2 1 Phospholipid methyltransferase ICMT PF04140.9 KOO23810.1 - 0.0072 16.5 0.0 0.018 15.2 0.0 1.7 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Steroid_dh PF02544.11 KOO23810.1 - 0.0084 15.8 0.0 0.02 14.6 0.0 1.6 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF4149 PF13664.1 KOO23810.1 - 0.95 9.5 4.4 0.71 9.9 0.2 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4149) Ank_2 PF12796.2 KOO23811.1 - 3e-31 107.6 5.3 2e-10 40.8 0.1 5.1 3 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank PF00023.25 KOO23811.1 - 3.3e-28 96.0 10.5 3.2e-05 23.5 0.1 7.1 6 1 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.1 KOO23811.1 - 6.7e-27 93.3 2.1 6.1e-07 29.7 0.0 5.8 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO23811.1 - 9.5e-26 89.2 8.5 1.1e-08 35.0 0.2 5.6 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO23811.1 - 1.4e-17 61.9 9.2 0.0008 19.4 0.2 7.1 7 0 0 7 7 7 4 Ankyrin repeat GRIP PF01465.15 KOO23811.1 - 0.003 17.0 0.0 0.0054 16.2 0.0 1.4 1 0 0 1 1 1 1 GRIP domain TFIIA PF03153.8 KOO23811.1 - 0.051 13.4 0.6 0.073 12.9 0.4 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF719 PF05334.8 KOO23811.1 - 0.15 12.0 1.5 1.3 8.9 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF719) ODV-E18 PF10717.4 KOO23813.1 - 0.064 12.6 0.3 0.13 11.7 0.2 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Mem_trans PF03547.13 KOO23813.1 - 1.5 7.0 9.0 0.47 8.6 4.0 1.6 1 1 1 2 2 2 0 Membrane transport protein TPR_11 PF13414.1 KOO23815.1 - 5.9e-09 35.4 5.0 0.018 14.6 0.4 4.1 2 1 2 4 4 4 3 TPR repeat TPR_16 PF13432.1 KOO23815.1 - 4.8e-08 33.4 20.8 0.00082 19.9 0.4 4.9 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOO23815.1 - 1.4e-06 28.4 19.7 0.014 15.9 1.1 5.6 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOO23815.1 - 2e-06 28.0 6.4 0.0017 18.6 0.1 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO23815.1 - 6e-06 25.7 5.8 0.91 9.6 0.1 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO23815.1 - 5.1e-05 23.1 0.4 0.066 13.4 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO23815.1 - 0.0018 17.8 2.2 14 5.4 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO23815.1 - 0.0035 17.2 0.5 0.24 11.3 0.1 3.4 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO23815.1 - 0.0062 16.2 0.0 14 5.7 0.0 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO23815.1 - 0.029 14.8 0.9 0.72 10.4 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO23815.1 - 0.051 13.3 3.0 0.79 9.6 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.1 KOO23815.1 - 1.3 9.0 5.4 2.1 8.3 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat CTP_transf_1 PF01148.15 KOO23816.1 - 0.022 14.4 0.9 0.029 14.0 0.7 1.3 1 0 0 1 1 1 0 Cytidylyltransferase family Transgly_assoc PF04226.8 KOO23816.1 - 0.22 11.6 3.4 0.72 9.9 0.1 2.7 2 2 0 2 2 2 0 Transglycosylase associated protein SET PF00856.23 KOO23817.1 - 0.0021 18.3 0.1 0.0058 16.9 0.0 1.7 2 0 0 2 2 2 1 SET domain Spc7_N PF15402.1 KOO23818.1 - 0.013 13.5 0.4 0.014 13.4 0.3 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 U-box PF04564.10 KOO23819.1 - 5.6e-21 74.2 0.0 1e-20 73.4 0.0 1.4 1 0 0 1 1 1 1 U-box domain Repressor_Mnt PF11423.3 KOO23820.1 - 0.68 9.3 10.4 49 3.3 0.1 5.2 5 0 0 5 5 5 0 Regulatory protein Mnt TGT_C1 PF14809.1 KOO23820.1 - 7.3 6.4 16.7 14 5.5 0.1 5.4 6 1 1 7 7 7 0 C1 domain of tRNA-guanine transglycosylase dimerisation TPR_12 PF13424.1 KOO23821.1 - 3.7e-88 289.5 36.0 1e-17 63.7 0.3 7.3 2 1 5 8 8 8 6 Tetratricopeptide repeat TPR_10 PF13374.1 KOO23821.1 - 3.9e-79 258.5 54.4 1.6e-11 43.7 0.2 11.1 10 1 1 11 11 11 9 Tetratricopeptide repeat TPR_1 PF00515.23 KOO23821.1 - 9.4e-25 85.1 13.9 0.00065 19.1 0.0 8.4 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.12 KOO23821.1 - 7.4e-22 75.4 23.3 0.025 14.4 0.0 9.4 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_4 PF07721.9 KOO23821.1 - 8.1e-20 69.1 51.3 0.055 13.9 1.0 11.5 11 0 0 11 11 10 8 Tetratricopeptide repeat TPR_17 PF13431.1 KOO23821.1 - 7.4e-18 63.1 4.2 0.43 10.8 0.0 9.3 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_8 PF13181.1 KOO23821.1 - 2.4e-16 58.1 9.7 0.02 14.6 0.0 8.1 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_11 PF13414.1 KOO23821.1 - 6.1e-14 51.4 10.6 4.8e-05 22.9 0.1 5.8 2 2 4 6 6 6 4 TPR repeat TPR_16 PF13432.1 KOO23821.1 - 9.3e-14 51.6 38.9 0.0033 18.0 0.2 8.5 1 1 8 9 9 9 6 Tetratricopeptide repeat TPR_19 PF14559.1 KOO23821.1 - 3.4e-12 46.5 27.5 0.0035 17.6 0.3 7.0 4 3 3 7 7 7 4 Tetratricopeptide repeat TPR_7 PF13176.1 KOO23821.1 - 8.9e-12 43.8 32.6 0.077 12.8 0.1 9.1 9 0 0 9 9 9 6 Tetratricopeptide repeat Osmo_CC PF08946.5 KOO23821.1 - 5.6e-11 42.2 4.3 2.1 8.4 0.0 7.9 8 0 0 8 8 8 1 Osmosensory transporter coiled coil ApoLp-III PF07464.6 KOO23821.1 - 2.1e-09 37.5 0.0 8.5 6.3 0.0 7.0 1 1 6 7 7 7 0 Apolipophorin-III precursor (apoLp-III) TPR_3 PF07720.7 KOO23821.1 - 2.4e-09 36.7 0.0 6.4 6.6 0.0 8.0 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO23821.1 - 3.2e-06 27.2 48.2 1.3 9.8 0.5 10.1 7 2 2 11 11 9 3 Tetratricopeptide repeat Nebulin PF00880.13 KOO23821.1 - 0.0047 16.4 0.0 68 3.3 0.0 4.3 4 0 0 4 4 4 0 Nebulin repeat HisKA_3 PF07730.8 KOO23821.1 - 0.017 15.4 25.4 0.82 10.0 1.3 7.6 7 2 1 8 8 8 0 Histidine kinase TPR_6 PF13174.1 KOO23821.1 - 0.054 13.9 17.5 38 5.0 0.0 8.6 9 1 0 9 9 8 0 Tetratricopeptide repeat MIT PF04212.13 KOO23821.1 - 2.2 8.2 5.6 19 5.2 0.1 4.2 5 1 0 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_21 PF09976.4 KOO23821.1 - 2.5 8.0 19.9 1.7 8.5 0.8 6.6 4 3 2 6 6 6 0 Tetratricopeptide repeat IFT43 PF15305.1 KOO23822.1 - 2.9e-24 85.7 11.5 4.4e-24 85.1 6.6 1.9 2 0 0 2 2 2 1 Intraflagellar transport protein 43 PP2C PF00481.16 KOO23823.1 - 3.4e-41 141.3 0.0 4.4e-41 140.9 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOO23823.1 - 0.00038 20.2 0.0 0.001 18.8 0.0 1.6 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) DUF953 PF06110.6 KOO23823.1 - 0.14 11.5 0.0 0.57 9.6 0.0 1.8 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF953) Ras PF00071.17 KOO23824.1 - 3.9e-60 201.9 1.0 4.5e-60 201.7 0.7 1.0 1 0 0 1 1 1 1 Ras family Arf PF00025.16 KOO23824.1 - 6e-21 74.4 0.2 7.6e-21 74.1 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 KOO23824.1 - 2.7e-18 66.5 0.0 4.2e-18 65.9 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Gtr1_RagA PF04670.7 KOO23824.1 - 4.1e-10 39.1 0.2 6.2e-10 38.6 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KOO23824.1 - 6.2e-07 29.0 0.2 1.2e-06 28.0 0.1 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOO23824.1 - 6.1e-06 26.1 0.0 1.7e-05 24.7 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.5 KOO23824.1 - 0.00085 18.5 0.4 0.0033 16.6 0.0 1.9 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.1 KOO23824.1 - 0.0013 18.7 0.3 0.074 13.0 0.1 2.4 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 KOO23824.1 - 0.013 15.5 0.0 0.037 14.1 0.0 1.7 1 1 1 2 2 2 0 AAA domain FeoB_N PF02421.13 KOO23824.1 - 0.021 14.1 0.3 0.38 10.0 0.2 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_29 PF13555.1 KOO23824.1 - 0.062 12.8 0.1 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF258 PF03193.11 KOO23824.1 - 0.063 12.4 0.1 0.25 10.4 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function, DUF258 GT36_AF PF06205.6 KOO23825.1 - 0.065 12.9 0.2 2 8.2 0.1 2.4 2 0 0 2 2 2 0 Glycosyltransferase 36 associated family EF-hand_5 PF13202.1 KOO23827.1 - 0.011 15.0 0.0 0.021 14.1 0.0 1.4 1 0 0 1 1 1 0 EF hand EF-hand_1 PF00036.27 KOO23827.1 - 0.014 14.6 0.0 0.026 13.8 0.0 1.4 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.1 KOO23827.1 - 0.14 12.0 0.0 0.34 10.9 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain Sulfotransfer_3 PF13469.1 KOO23828.1 - 0.0002 22.3 11.5 0.003 18.4 8.0 2.7 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.22 KOO23828.1 - 0.0014 17.9 0.0 0.038 13.2 0.0 2.4 2 1 0 2 2 2 1 Sulfotransferase domain Rootletin PF15035.1 KOO23829.1 - 0.012 15.6 16.5 0.012 15.6 11.5 4.1 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion Involucrin PF00904.12 KOO23829.1 - 4.9 7.9 8.1 1 10.0 0.9 3.5 2 0 0 2 2 2 0 Involucrin repeat NHL PF01436.16 KOO23831.1 - 6e-31 104.8 0.7 2.4e-07 30.3 0.0 5.5 5 0 0 5 5 5 5 NHL repeat Arylesterase PF01731.15 KOO23831.1 - 8.2e-10 38.5 0.0 0.52 10.3 0.0 5.6 5 0 0 5 5 5 3 Arylesterase SGL PF08450.7 KOO23831.1 - 4.3e-05 23.0 0.0 0.91 8.8 0.0 4.0 2 1 1 3 3 3 3 SMP-30/Gluconolaconase/LRE-like region Lactonase PF10282.4 KOO23831.1 - 0.023 13.7 0.0 3.9 6.4 0.0 2.9 3 0 0 3 3 3 0 Lactonase, 7-bladed beta-propeller Ldl_recept_b PF00058.12 KOO23831.1 - 0.1 12.9 0.1 39 4.6 0.0 3.8 4 0 0 4 4 4 0 Low-density lipoprotein receptor repeat class B UQ_con PF00179.21 KOO23833.1 - 1.7e-24 85.8 0.0 2.3e-24 85.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.8 KOO23833.1 - 0.0043 16.7 0.0 0.055 13.1 0.0 2.5 2 1 0 2 2 2 1 UEV domain RWD PF05773.17 KOO23833.1 - 0.11 12.3 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 RWD domain Methyltransf_11 PF08241.7 KOO23835.1 - 3.6e-23 81.8 0.0 6.5e-23 81.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO23835.1 - 5.7e-15 55.2 0.0 8.5e-15 54.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO23835.1 - 8.9e-15 54.7 0.0 1.3e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 KOO23835.1 - 1e-14 54.2 0.0 1.4e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.1 KOO23835.1 - 3.7e-12 46.4 0.0 6.9e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO23835.1 - 6.2e-12 46.0 0.0 1.3e-11 45.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO23835.1 - 8.4e-11 42.2 0.0 1.3e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO23835.1 - 5.7e-10 39.2 0.1 1.8e-09 37.6 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO23835.1 - 8e-10 38.2 0.0 1.5e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.9 KOO23835.1 - 0.0048 16.2 0.0 0.0081 15.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.7 KOO23835.1 - 0.018 14.4 0.0 0.03 13.6 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW PCMT PF01135.14 KOO23835.1 - 0.024 14.1 0.0 0.036 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) NAS PF03059.11 KOO23835.1 - 0.043 12.9 0.0 0.068 12.3 0.0 1.2 1 0 0 1 1 1 0 Nicotianamine synthase protein DREV PF05219.7 KOO23835.1 - 0.06 12.2 0.0 0.091 11.6 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_29 PF03141.11 KOO23835.1 - 0.061 11.6 0.0 0.093 11.0 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase ADH_zinc_N PF00107.21 KOO23835.1 - 0.091 12.3 0.0 0.25 10.9 0.0 1.7 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Methyltransf_9 PF08003.6 KOO23835.1 - 0.19 10.4 0.0 0.25 10.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Ribosomal_L10 PF00466.15 KOO23836.1 - 7.9e-23 80.2 0.0 1.5e-22 79.4 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.14 KOO23836.1 - 5.5e-09 36.2 7.1 5.5e-09 36.2 4.9 2.2 3 0 0 3 3 3 1 60s Acidic ribosomal protein WD40 PF00400.27 KOO23837.1 - 1e-40 136.1 5.5 9.4e-10 37.9 0.0 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat eIF2A PF08662.6 KOO23837.1 - 1.9e-07 30.9 0.4 0.049 13.3 0.0 3.9 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 KOO23837.1 - 0.00055 18.2 3.6 0.014 13.5 0.1 2.9 2 1 1 3 3 3 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 KOO23837.1 - 0.035 12.8 0.6 8.2 5.0 0.0 2.7 2 1 1 3 3 3 0 Nup133 N terminal like GrpE PF01025.14 KOO23838.1 - 1.1 8.7 6.8 0.17 11.4 1.2 2.0 1 1 1 2 2 2 0 GrpE RNA_ligase PF09414.5 KOO23839.1 - 1.3e-22 80.4 0.0 1e-20 74.3 0.0 2.1 1 1 0 1 1 1 1 RNA ligase DUF2470 PF10615.4 KOO23841.1 - 0.0073 16.5 0.0 2.8 8.2 0.0 2.8 3 1 0 3 3 3 2 Protein of unknown function (DUF2470) DUF2306 PF10067.4 KOO23842.1 - 0.84 9.7 4.5 9.8 6.3 0.2 2.2 1 1 1 2 2 2 0 Predicted membrane protein (DUF2306) FHA PF00498.21 KOO23845.1 - 3.4e-13 49.4 0.0 5.1e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 FHA domain PDZ PF00595.19 KOO23846.1 - 0.0035 17.4 0.0 0.0095 16.0 0.0 1.7 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) UIM PF02809.15 KOO23846.1 - 0.029 13.9 2.5 0.089 12.4 1.7 1.9 1 0 0 1 1 1 0 Ubiquitin interaction motif Mito_fiss_reg PF05308.6 KOO23846.1 - 2.1 7.6 5.6 17 4.6 3.3 2.3 2 0 0 2 2 2 0 Mitochondrial fission regulator DUF2358 PF10184.4 KOO23847.1 - 1.7e-17 63.3 0.0 2.5e-17 62.8 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) SnoaL_2 PF12680.2 KOO23847.1 - 1.7e-05 25.1 0.1 3.2e-05 24.2 0.1 1.5 1 0 0 1 1 1 1 SnoaL-like domain DUF2499 PF10693.4 KOO23848.1 - 1.6e-32 111.3 4.8 3.7e-32 110.2 3.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2499) DUF3593 PF12159.3 KOO23848.1 - 3.7e-29 100.3 1.0 3.7e-29 100.3 0.7 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3593) SopA_C PF13979.1 KOO23848.1 - 0.19 11.3 0.1 0.3 10.6 0.1 1.2 1 0 0 1 1 1 0 SopA-like catalytic domain GpcrRhopsn4 PF10192.4 KOO23848.1 - 1.2 8.2 5.8 0.099 11.8 0.6 1.7 2 0 0 2 2 2 0 Rhodopsin-like GPCR transmembrane domain EF-hand_1 PF00036.27 KOO23849.1 - 6.3e-19 65.7 3.8 3.4e-05 22.8 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO23849.1 - 1.5e-18 64.9 3.0 3.5e-06 26.4 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO23849.1 - 5.5e-18 64.8 5.8 2e-10 40.6 0.0 3.4 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO23849.1 - 1.4e-15 55.8 3.6 4.2e-05 22.6 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO23849.1 - 1.9e-11 43.4 4.9 0.026 14.1 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_4 PF12763.2 KOO23849.1 - 0.028 14.1 0.4 19 5.0 0.0 3.2 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO23849.1 - 0.029 14.4 0.1 4.1 7.4 0.0 3.3 2 2 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region RhoGEF PF00621.15 KOO23850.1 - 3.2e-36 124.8 0.0 2.2e-35 122.1 0.0 2.0 2 0 0 2 2 2 1 RhoGEF domain AAA_17 PF13207.1 KOO23852.1 - 3.4e-05 24.6 0.0 0.00016 22.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain ADK PF00406.17 KOO23852.1 - 0.00098 19.0 0.1 0.027 14.3 0.0 2.8 3 0 0 3 3 3 1 Adenylate kinase AAA_33 PF13671.1 KOO23852.1 - 0.0016 18.3 5.1 0.0085 15.9 0.1 3.8 3 1 0 3 3 3 1 AAA domain AAA_18 PF13238.1 KOO23852.1 - 0.19 12.0 0.7 0.35 11.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain KTI12 PF08433.5 KOO23852.1 - 0.32 10.1 0.0 0.53 9.4 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 O-FucT PF10250.4 KOO23853.1 - 9.1e-16 57.8 0.0 2.6e-15 56.3 0.0 1.6 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase DUF791 PF05631.9 KOO23854.1 - 5.3e-69 232.5 8.1 4e-54 183.6 1.2 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF791) MFS_1 PF07690.11 KOO23854.1 - 5.6e-18 64.7 21.4 7.3e-18 64.3 14.4 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Pyr_redox_2 PF07992.9 KOO23855.1 - 9.2e-31 107.2 13.8 3.9e-30 105.2 9.6 3.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 KOO23855.1 - 1.2e-23 83.1 0.1 2.4e-23 82.2 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 KOO23855.1 - 9.5e-16 57.9 6.6 2.1e-12 47.2 0.2 3.3 4 0 0 4 4 3 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 KOO23855.1 - 5e-09 35.4 15.3 8.5e-05 21.5 3.6 3.4 3 1 0 3 3 3 3 Glucose inhibited division protein A Pyr_redox_3 PF13738.1 KOO23855.1 - 1.6e-08 34.8 0.1 3.3e-07 30.5 0.1 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 KOO23855.1 - 6.5e-08 32.0 2.8 6.5e-08 32.0 2.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 KOO23855.1 - 4.5e-07 29.7 6.5 8.6e-05 22.4 0.8 2.8 2 1 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 KOO23855.1 - 1.4e-06 27.4 18.0 8.5e-06 24.8 2.4 4.2 3 1 0 4 4 4 2 FAD binding domain DAO PF01266.19 KOO23855.1 - 2.8e-05 23.2 22.4 0.013 14.4 2.3 3.5 2 2 1 3 3 3 3 FAD dependent oxidoreductase Thi4 PF01946.12 KOO23855.1 - 0.00038 19.6 4.5 0.0029 16.7 0.5 2.3 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.9 KOO23855.1 - 0.00064 18.2 1.1 0.00064 18.2 0.7 3.1 3 0 0 3 3 3 1 HI0933-like protein Lycopene_cycl PF05834.7 KOO23855.1 - 0.00093 18.2 6.5 0.16 10.8 0.1 2.7 3 0 0 3 3 3 2 Lycopene cyclase protein AlaDh_PNT_C PF01262.16 KOO23855.1 - 0.0012 18.4 1.0 0.29 10.6 0.3 2.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.14 KOO23855.1 - 0.0021 17.1 5.7 0.092 11.7 0.4 2.4 2 0 0 2 2 2 2 FAD binding domain NAD_binding_7 PF13241.1 KOO23855.1 - 0.0036 17.5 1.9 0.033 14.4 0.1 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding TrkA_N PF02254.13 KOO23855.1 - 0.012 15.6 1.0 0.17 11.8 0.0 2.7 2 1 0 2 2 2 0 TrkA-N domain XdhC_C PF13478.1 KOO23855.1 - 0.021 15.1 0.2 0.42 10.9 0.0 2.3 2 0 0 2 2 2 0 XdhC Rossmann domain K_oxygenase PF13434.1 KOO23855.1 - 0.059 12.2 0.6 0.31 9.9 0.0 2.1 3 0 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) CPSase_L_chain PF00289.17 KOO23855.1 - 0.059 13.4 0.0 4.7 7.3 0.0 3.1 2 1 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, N-terminal domain NAD_Gly3P_dh_N PF01210.18 KOO23855.1 - 0.06 13.0 0.9 1.2 8.8 0.0 2.5 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.12 KOO23855.1 - 1.7 9.1 14.0 0.89 10.0 0.1 3.8 4 0 0 4 4 3 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_9 PF13454.1 KOO23855.1 - 3.4 7.4 8.1 16 5.2 0.3 3.3 3 0 0 3 3 3 0 FAD-NAD(P)-binding 3HCDH_N PF02737.13 KOO23855.1 - 4.1 7.0 14.1 1 8.9 0.0 3.5 3 1 1 4 4 4 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PP2C PF00481.16 KOO23856.1 - 1.4e-40 139.3 0.0 2e-40 138.8 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 KOO23856.1 - 1.5e-08 34.3 0.1 2.8e-08 33.4 0.1 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C DUF3464 PF11947.3 KOO23857.1 - 9.1e-33 112.9 0.0 1.5e-32 112.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3464) PDZ PF00595.19 KOO23857.1 - 2.3e-06 27.6 0.1 5e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO23857.1 - 0.00038 20.2 0.6 0.0019 18.0 0.1 2.4 3 0 0 3 3 3 1 PDZ domain Oxidored_q6 PF01058.17 KOO23858.1 - 3e-23 81.8 0.0 3.5e-23 81.6 0.0 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Ion_trans_2 PF07885.11 KOO23859.1 - 3.3e-14 52.3 2.5 3.3e-14 52.3 1.8 2.0 2 0 0 2 2 2 1 Ion channel WD40 PF00400.27 KOO23860.1 - 4.8e-26 89.6 19.4 6.6e-07 28.9 0.1 7.9 8 0 0 8 8 8 5 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 KOO23860.1 - 0.0018 17.1 0.9 0.37 9.5 0.1 3.7 3 1 0 3 3 3 1 Coatomer WD associated region eIF2A PF08662.6 KOO23860.1 - 0.0044 16.7 0.1 0.11 12.1 0.0 3.0 3 1 1 4 4 4 1 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.7 KOO23860.1 - 0.033 12.0 0.5 7.9 4.1 0.0 3.3 4 0 0 4 4 4 0 IKI3 family AIP3 PF03915.8 KOO23861.1 - 0.0022 16.9 0.2 0.0022 16.9 0.1 2.4 1 1 1 3 3 3 1 Actin interacting protein 3 Reo_sigmaC PF04582.7 KOO23861.1 - 0.0074 15.5 3.2 0.1 11.7 0.2 2.1 1 1 1 2 2 2 1 Reovirus sigma C capsid protein WEMBL PF05701.6 KOO23861.1 - 0.11 10.9 36.0 0.33 9.3 25.0 1.7 1 1 0 1 1 1 0 Weak chloroplast movement under blue light NPV_P10 PF05531.7 KOO23861.1 - 0.2 11.9 2.1 2.4 8.4 0.2 2.8 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Mnd1 PF03962.10 KOO23861.1 - 0.7 9.5 24.5 1.5 8.4 1.2 3.0 1 1 2 3 3 3 0 Mnd1 family Atg14 PF10186.4 KOO23861.1 - 1.1 8.1 24.2 0.35 9.7 8.7 2.2 1 1 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 CorA PF01544.13 KOO23861.1 - 1.3 7.9 6.5 5.5 5.9 0.1 2.1 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Rsd_AlgQ PF04353.8 KOO23861.1 - 2.3 7.9 5.3 0.5 10.0 0.1 2.3 3 0 0 3 3 3 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ Phage_GP20 PF06810.6 KOO23861.1 - 2.3 7.6 10.6 0.57 9.5 0.1 2.9 2 1 1 3 3 3 0 Phage minor structural protein GP20 V_ATPase_I PF01496.14 KOO23861.1 - 5.6 4.6 6.6 8.6 4.0 0.1 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Syntaxin PF00804.20 KOO23861.1 - 6.8 6.9 8.5 30 4.8 1.3 2.9 1 1 0 2 2 2 0 Syntaxin EMP70 PF02990.11 KOO23863.1 - 4.9e-188 625.8 9.3 7e-183 608.8 4.3 2.4 2 1 1 3 3 3 2 Endomembrane protein 70 Thaumatin PF00314.12 KOO23864.1 - 4.9e-20 71.8 2.7 6.5e-20 71.5 1.9 1.2 1 0 0 1 1 1 1 Thaumatin family DUF2484 PF10658.4 KOO23864.1 - 0.037 14.1 0.3 0.086 12.9 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2484) TPR_10 PF13374.1 KOO23866.1 - 4.7e-18 64.4 1.2 1.1e-08 34.7 0.1 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO23866.1 - 7e-14 51.5 1.6 4.3e-13 49.0 0.9 1.9 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO23866.1 - 2.8e-07 29.9 1.2 0.0022 17.7 0.3 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO23866.1 - 4e-07 30.5 0.4 5.5e-07 30.0 0.3 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO23866.1 - 2.2e-06 27.0 0.4 0.072 12.7 0.1 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO23866.1 - 4.3e-06 26.8 0.3 0.029 14.9 0.1 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO23866.1 - 3e-05 23.5 4.3 0.0013 18.3 0.5 1.9 1 1 1 2 2 2 2 TPR repeat TPR_19 PF14559.1 KOO23866.1 - 0.00065 19.9 0.7 0.0013 19.0 0.4 1.6 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO23866.1 - 0.00088 18.8 0.1 1.9 8.5 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO23866.1 - 0.0015 18.5 0.1 0.66 10.3 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_3 PF07720.7 KOO23866.1 - 0.0024 17.6 0.0 0.3 10.9 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO23866.1 - 0.0091 15.7 1.2 0.96 9.3 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 KOO23866.1 - 0.034 14.2 0.1 0.072 13.2 0.0 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 KOO23866.1 - 0.077 13.4 0.7 16 6.2 0.0 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.9 KOO23866.1 - 0.091 13.2 1.7 6.4 7.5 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat AOX PF01786.12 KOO23867.1 - 1.8e-55 187.5 0.1 2.6e-55 187.0 0.1 1.3 1 0 0 1 1 1 1 Alternative oxidase Methyltransf_21 PF05050.7 KOO23868.1 - 8e-09 35.6 0.0 1e-08 35.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_22 PF13383.1 KOO23868.1 - 0.064 12.7 0.0 0.064 12.7 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain UPF0223 PF05256.7 KOO23869.1 - 0.031 14.3 1.8 0.049 13.7 0.1 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0223) Pkinase PF00069.20 KOO23870.1 - 2.9e-57 193.7 0.0 3.5e-57 193.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO23870.1 - 8.3e-32 110.2 0.0 1e-31 109.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO23870.1 - 3.9e-11 42.4 0.0 2.1e-09 36.7 0.0 2.2 2 0 0 2 2 2 2 Kinase-like CRAL_TRIO_2 PF13716.1 KOO23870.1 - 0.055 13.3 0.0 0.093 12.6 0.0 1.2 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain Thioredoxin PF00085.15 KOO23871.1 - 9.3e-05 22.0 0.0 9.7e-05 22.0 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Amino_oxidase PF01593.19 KOO23872.1 - 1.5e-32 113.2 0.1 1.9e-32 112.9 0.1 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase GILT PF03227.11 KOO23873.1 - 3.7e-13 49.2 0.8 6.7e-13 48.4 0.6 1.4 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) DUF3248 PF11609.3 KOO23874.1 - 0.13 12.0 0.4 0.38 10.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3248) SpoIIIAH PF12685.2 KOO23876.1 - 0.048 13.1 9.1 0.051 13.0 6.3 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF724 PF05266.9 KOO23876.1 - 0.18 11.4 15.3 0.23 11.0 10.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) NAM-associated PF14303.1 KOO23876.1 - 0.92 9.8 16.3 1.2 9.4 11.3 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain AAA_11 PF13086.1 KOO23876.1 - 1.1 8.7 7.6 1.4 8.4 5.2 1.2 1 0 0 1 1 1 0 AAA domain V_ATPase_I PF01496.14 KOO23876.1 - 1.3 6.8 7.6 1.2 6.8 5.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Vfa1 PF08432.5 KOO23876.1 - 3.7 7.5 14.4 4.8 7.1 10.0 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Methyltransf_21 PF05050.7 KOO23877.1 - 7.1e-15 55.3 0.0 2.5e-14 53.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase FkbM domain LRR_6 PF13516.1 KOO23879.1 - 2.2e-24 82.7 2.0 0.0024 17.7 0.0 7.9 8 0 0 8 8 8 6 Leucine Rich repeat LRR_4 PF12799.2 KOO23879.1 - 8e-09 34.9 0.0 0.076 12.6 0.0 5.1 4 1 2 6 6 6 3 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO23879.1 - 3e-07 29.5 0.4 36 5.1 0.0 6.9 7 0 0 7 7 7 0 Leucine rich repeat LRR_1 PF00560.28 KOO23879.1 - 0.00014 21.4 0.9 22 5.5 0.0 5.8 7 1 0 7 7 7 1 Leucine Rich Repeat LRR_8 PF13855.1 KOO23879.1 - 0.0029 17.3 3.7 3.2 7.5 0.0 4.7 4 1 1 5 5 5 1 Leucine rich repeat LRR_8 PF13855.1 KOO23880.1 - 3.1e-24 84.5 16.9 2.6e-07 30.3 0.7 9.2 5 2 2 7 7 7 6 Leucine rich repeat LRR_4 PF12799.2 KOO23880.1 - 4.3e-24 83.6 31.2 2e-07 30.4 1.1 11.4 11 2 2 13 13 13 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO23880.1 - 6.8e-16 56.5 31.7 0.014 15.3 0.0 15.5 16 0 0 16 16 16 4 Leucine Rich repeat LRR_1 PF00560.28 KOO23880.1 - 6.6e-10 37.6 22.9 0.53 10.5 0.0 14.0 16 0 0 16 16 16 2 Leucine Rich Repeat LRR_7 PF13504.1 KOO23880.1 - 0.002 18.0 36.7 20 5.9 0.1 13.6 15 0 0 15 15 15 3 Leucine rich repeat SH3_3 PF08239.6 KOO23880.1 - 0.011 15.8 0.1 0.032 14.4 0.1 1.8 1 0 0 1 1 1 0 Bacterial SH3 domain DUF4033 PF13225.1 KOO23881.1 - 0.36 10.4 3.1 1.1 8.9 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4033) ACTH_domain PF00976.13 KOO23882.1 - 0.067 13.0 0.1 0.15 11.9 0.1 1.6 1 0 0 1 1 1 0 Corticotropin ACTH domain PTS_2-RNA PF01885.11 KOO23883.1 - 7.9e-34 116.5 0.0 1.8e-33 115.4 0.0 1.6 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family NACHT PF05729.7 KOO23883.1 - 2.9e-05 23.7 0.1 0.00011 21.8 0.0 2.0 2 0 0 2 2 2 1 NACHT domain Spc7 PF08317.6 KOO23883.1 - 0.67 8.5 11.9 0.033 12.8 2.5 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein Ricin_B_lectin PF00652.17 KOO23884.1 - 5.3e-23 81.3 6.6 7.6e-23 80.8 4.6 1.2 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.1 KOO23884.1 - 1.2e-14 54.5 5.4 6.3e-08 32.9 0.3 2.6 2 1 1 3 3 3 2 Ricin-type beta-trefoil lectin domain-like CDtoxinA PF03498.9 KOO23884.1 - 0.0015 17.9 0.2 0.22 10.9 0.0 2.3 1 1 1 2 2 2 2 Cytolethal distending toxin A/C family ET PF01684.11 KOO23884.1 - 0.07 13.1 3.4 0.33 11.0 0.0 3.1 2 1 0 3 3 3 0 ET module LRR_8 PF13855.1 KOO23885.1 - 1.3e-05 24.8 0.1 1.3e-05 24.8 0.1 2.0 2 0 0 2 2 2 1 Leucine rich repeat RRM_6 PF14259.1 KOO23885.1 - 0.0032 17.4 0.0 0.019 14.9 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) LRR_4 PF12799.2 KOO23885.1 - 0.018 14.6 0.1 0.018 14.6 0.0 2.6 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO23885.1 - 0.028 14.4 0.1 1 9.6 0.0 3.3 3 0 0 3 3 3 0 Leucine Rich repeat LRR_1 PF00560.28 KOO23885.1 - 0.038 14.0 0.2 0.21 11.7 0.0 2.4 2 0 0 2 2 2 0 Leucine Rich Repeat TRP PF06011.7 KOO23885.1 - 0.041 12.4 0.4 0.095 11.2 0.3 1.6 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel RRM_5 PF13893.1 KOO23885.1 - 0.097 12.5 0.1 0.32 10.8 0.0 1.9 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OmpH PF03938.9 KOO23885.1 - 0.18 11.7 17.7 0.013 15.4 7.0 2.6 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) RRM_1 PF00076.17 KOO23885.1 - 0.26 10.9 0.2 1.2 8.8 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LtrA PF06772.6 KOO23886.1 - 0.00012 21.1 0.9 0.00051 19.0 0.6 2.0 1 1 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) Tricorn_PDZ PF14685.1 KOO23887.1 - 0.015 15.1 0.6 0.93 9.3 0.0 3.5 4 0 0 4 4 4 0 Tricorn protease PDZ domain SRP-alpha_N PF04086.8 KOO23887.1 - 6.6 6.0 8.5 11 5.2 5.9 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal MFS_1 PF07690.11 KOO23888.1 - 9.3e-13 47.6 30.7 9.3e-13 47.6 21.3 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.1 KOO23888.1 - 0.0014 17.0 16.2 0.0053 15.1 1.5 2.9 2 1 1 3 3 3 2 MFS/sugar transport protein PKD_channel PF08016.7 KOO23889.1 - 1.5e-60 204.7 0.2 2.2e-60 204.2 0.2 1.2 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.26 KOO23889.1 - 2.4e-07 30.2 8.7 6.5e-07 28.7 6.0 1.8 1 1 0 1 1 1 1 Ion transport protein GTP_EFTU PF00009.22 KOO23890.1 - 3.9e-39 134.0 0.3 6.2e-39 133.3 0.2 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain eIF2_C PF09173.6 KOO23890.1 - 1.3e-37 127.7 0.1 2.8e-37 126.6 0.1 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.20 KOO23890.1 - 3.3e-11 43.1 0.4 1e-10 41.5 0.3 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 KOO23890.1 - 0.012 15.5 0.0 0.025 14.5 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Dynamin_N PF00350.18 KOO23890.1 - 0.039 13.7 0.4 0.45 10.3 0.1 2.4 2 1 0 2 2 2 0 Dynamin family Ribosomal_S3Ae PF01015.13 KOO23891.1 - 1.4e-76 256.2 1.3 1.6e-76 255.9 0.9 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family MRP-L27 PF09809.4 KOO23891.1 - 0.079 12.5 0.1 0.17 11.4 0.1 1.6 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L27 AroM PF07302.6 KOO23891.1 - 0.12 11.7 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 AroM protein Clat_adaptor_s PF01217.15 KOO23891.1 - 0.12 12.0 0.5 1.3 8.7 0.1 2.1 2 0 0 2 2 2 0 Clathrin adaptor complex small chain SRP19 PF01922.12 KOO23892.1 - 7.6e-23 80.9 0.0 1.2e-22 80.2 0.0 1.3 1 0 0 1 1 1 1 SRP19 protein Asp_protease_2 PF13650.1 KOO23892.1 - 9.6e-05 22.8 0.0 0.084 13.3 0.0 2.5 2 0 0 2 2 2 2 Aspartyl protease Asp PF00026.18 KOO23892.1 - 0.038 13.2 0.0 0.13 11.5 0.0 1.7 2 0 0 2 2 2 0 Eukaryotic aspartyl protease gag-asp_proteas PF13975.1 KOO23892.1 - 0.071 12.9 0.0 2.7 7.8 0.0 2.5 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease tRNA_Me_trans PF03054.11 KOO23894.1 - 9.1e-100 333.6 0.0 1e-99 333.4 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase GARS_A PF01071.14 KOO23895.1 - 1.6e-72 243.1 0.0 2.3e-72 242.6 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.10 KOO23895.1 - 2e-29 101.9 0.3 4.9e-29 100.7 0.2 1.7 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.11 KOO23895.1 - 1.2e-24 86.2 1.1 3.4e-24 84.8 0.8 1.8 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain ATP-grasp_4 PF13535.1 KOO23895.1 - 5.2e-18 65.4 0.0 9.4e-18 64.5 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 KOO23895.1 - 3.6e-10 39.1 0.0 1.5e-09 37.0 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon CPSase_L_D2 PF02786.12 KOO23895.1 - 4.9e-07 29.2 0.0 9.1e-07 28.3 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp PF02222.17 KOO23895.1 - 2.1e-06 27.1 0.0 4.4e-06 26.1 0.0 1.5 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.9 KOO23895.1 - 3.7e-05 23.6 0.0 6.9e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.1 KOO23895.1 - 0.018 14.2 0.0 0.045 12.9 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain Dala_Dala_lig_C PF07478.8 KOO23895.1 - 0.022 14.1 0.0 0.034 13.5 0.0 1.4 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus Dpy-30 PF05186.8 KOO23895.1 - 0.042 13.3 0.0 0.086 12.3 0.0 1.5 1 0 0 1 1 1 0 Dpy-30 motif ATP-grasp_2 PF08442.5 KOO23895.1 - 0.049 13.0 0.1 0.26 10.6 0.0 2.0 2 0 0 2 2 2 0 ATP-grasp domain ATP-grasp_3 PF02655.9 KOO23896.1 - 6.1e-09 35.9 0.0 1.8e-08 34.4 0.0 1.7 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_4 PF13535.1 KOO23896.1 - 3.2e-06 27.0 0.0 1.2e-05 25.1 0.0 1.8 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 KOO23896.1 - 0.03 13.0 0.0 0.14 10.8 0.0 1.9 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon ShK PF01549.19 KOO23898.1 - 2e-07 31.2 6.5 2e-07 31.2 4.5 3.9 3 0 0 3 3 3 2 ShK domain-like FA_desaturase PF00487.19 KOO23899.1 - 6.1e-34 117.6 23.8 6.1e-34 117.6 16.5 2.1 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.23 KOO23899.1 - 3.9e-07 29.7 0.1 7.4e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DEAD PF00270.24 KOO23900.1 - 7.4e-44 149.2 0.0 1.1e-43 148.6 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 KOO23900.1 - 0.036 13.9 0.0 0.073 12.8 0.0 1.6 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Kelch_4 PF13418.1 KOO23901.1 - 2e-32 110.6 2.6 1.3e-05 24.8 0.0 5.7 5 0 0 5 5 5 5 Galactose oxidase, central domain BTB PF00651.26 KOO23901.1 - 2.6e-29 101.4 0.2 1.3e-28 99.2 0.1 2.0 1 1 1 2 2 2 1 BTB/POZ domain Kelch_5 PF13854.1 KOO23901.1 - 1.2e-26 92.1 0.0 0.00015 21.6 0.0 5.6 5 0 0 5 5 5 5 Kelch motif Kelch_3 PF13415.1 KOO23901.1 - 1.4e-24 85.6 16.7 6.5e-07 29.3 0.0 6.7 8 0 0 8 8 8 4 Galactose oxidase, central domain Kelch_2 PF07646.10 KOO23901.1 - 6.2e-23 79.6 0.1 0.0005 19.7 0.0 5.8 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.1 KOO23901.1 - 1.9e-22 78.4 0.1 3e-05 23.9 0.0 5.5 4 1 1 5 5 5 4 Kelch motif Kelch_1 PF01344.20 KOO23901.1 - 8e-19 66.9 0.0 0.00099 18.6 0.0 5.5 5 0 0 5 5 5 4 Kelch motif BACK PF07707.10 KOO23901.1 - 0.00011 22.0 0.1 0.00068 19.4 0.0 2.1 2 0 0 2 2 2 1 BTB And C-terminal Kelch DUF3342 PF11822.3 KOO23901.1 - 0.08 12.0 0.1 2 7.5 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3342) Flagellin_C PF00700.16 KOO23902.1 - 0.0016 18.5 7.6 0.0035 17.4 5.3 1.5 1 0 0 1 1 1 1 Bacterial flagellin C-terminal helical region IQ PF00612.22 KOO23902.1 - 0.027 14.0 0.4 0.063 12.9 0.3 1.6 1 0 0 1 1 1 0 IQ calmodulin-binding motif ERM PF00769.14 KOO23902.1 - 1.1 8.7 14.3 1.9 7.9 9.9 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family RunxI PF08504.6 KOO23902.1 - 4.5 7.7 6.2 1 9.8 0.4 2.6 1 1 0 3 3 3 0 Runx inhibition domain TFIIA PF03153.8 KOO23902.1 - 8.3 6.1 12.3 9.7 5.9 8.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Sugar_tr PF00083.19 KOO23903.1 - 6.1e-32 110.7 7.1 7.7e-32 110.4 4.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOO23903.1 - 2.5e-15 56.0 17.1 3e-15 55.8 11.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TPT PF03151.11 KOO23904.1 - 8.6e-10 38.4 6.3 8.6e-10 38.4 4.3 2.4 3 0 0 3 3 3 1 Triose-phosphate Transporter family UAA PF08449.6 KOO23904.1 - 5.8e-08 32.0 7.1 7.8e-08 31.5 4.9 1.2 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 KOO23904.1 - 3.5e-07 30.3 22.7 0.00013 22.0 3.9 3.1 2 1 1 3 3 3 2 EamA-like transporter family Helicase_C PF00271.26 KOO23905.1 - 9.8e-26 89.4 0.0 1.4e-25 88.9 0.0 1.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_2 PF13307.1 KOO23905.1 - 9.7e-05 22.3 0.0 0.00013 21.9 0.0 1.1 1 0 0 1 1 1 1 Helicase C-terminal domain MFS_2 PF13347.1 KOO23906.1 - 0.0066 14.8 0.5 0.0066 14.8 0.3 1.4 2 0 0 2 2 2 1 MFS/sugar transport protein Astacin PF01400.19 KOO23907.1 - 3.4e-30 104.8 0.2 4.8e-30 104.3 0.1 1.1 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Reprolysin_4 PF13583.1 KOO23907.1 - 0.00068 19.2 0.5 0.012 15.1 0.2 2.1 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Metallopep PF12044.3 KOO23907.1 - 0.0018 16.7 0.1 0.0029 16.1 0.1 1.3 1 0 0 1 1 1 1 Putative peptidase family Reprolysin_2 PF13574.1 KOO23907.1 - 0.0023 17.9 0.3 0.0041 17.1 0.2 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.4 KOO23907.1 - 0.015 14.1 0.1 0.025 13.4 0.1 1.3 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M10 PF00413.19 KOO23907.1 - 0.028 14.1 1.8 0.045 13.4 1.2 1.6 1 1 0 1 1 1 0 Matrixin Reprolysin_5 PF13688.1 KOO23907.1 - 0.064 13.1 0.4 0.1 12.5 0.3 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 DnaJ PF00226.26 KOO23909.1 - 7.1e-18 64.1 0.7 1.4e-17 63.2 0.5 1.5 1 0 0 1 1 1 1 DnaJ domain Ank_3 PF13606.1 KOO23909.1 - 1e-08 34.5 0.0 0.0092 16.1 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.2 KOO23909.1 - 7.8e-08 32.5 0.0 3.8e-07 30.3 0.0 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO23909.1 - 1.7e-06 28.0 0.0 0.12 12.6 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO23909.1 - 3.6e-05 24.1 0.0 0.0006 20.2 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.25 KOO23909.1 - 0.002 17.8 0.1 0.31 10.9 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeat LRR_6 PF13516.1 KOO23910.1 - 3.3e-09 35.8 0.0 0.079 13.0 0.0 4.8 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.2 KOO23910.1 - 0.00047 19.7 0.0 0.43 10.2 0.1 3.1 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO23910.1 - 0.015 15.0 0.1 1.6 8.5 0.0 3.1 2 1 0 2 2 2 0 Leucine rich repeat DUF677 PF05055.7 KOO23910.1 - 0.024 13.3 1.1 0.046 12.3 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF677) LRR_7 PF13504.1 KOO23910.1 - 0.045 13.9 0.1 17 6.1 0.0 4.0 3 0 0 3 3 3 0 Leucine rich repeat Tup_N PF08581.5 KOO23910.1 - 0.066 13.4 0.8 0.14 12.3 0.6 1.6 1 0 0 1 1 1 0 Tup N-terminal Striatin PF08232.7 KOO23910.1 - 3.9 7.7 15.5 0.52 10.6 6.5 2.3 1 1 1 2 2 2 0 Striatin family DUF179 PF02622.10 KOO23911.1 - 1.3e-15 57.4 0.0 2.1e-15 56.6 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized ACR, COG1678 Chromo PF00385.19 KOO23911.1 - 0.00013 21.5 0.1 0.00029 20.4 0.1 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RabGAP-TBC PF00566.13 KOO23912.1 - 4.2e-25 88.4 0.0 5.3e-25 88.1 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Peptidase_C1 PF00112.18 KOO23913.1 - 3.2e-56 190.6 0.8 4.5e-56 190.1 0.5 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KOO23913.1 - 1.8e-09 37.7 0.1 3.2e-09 36.8 0.1 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.10 KOO23913.1 - 1.9e-05 23.4 0.1 0.00039 19.0 0.0 2.1 2 0 0 2 2 2 1 Peptidase C1-like family SAP PF02037.22 KOO23914.1 - 6.8e-07 28.6 0.1 1.6e-06 27.4 0.1 1.7 1 0 0 1 1 1 1 SAP domain Skp1 PF01466.14 KOO23914.1 - 0.1 12.6 0.0 0.41 10.7 0.0 2.0 2 0 0 2 2 2 0 Skp1 family, dimerisation domain Ion_trans PF00520.26 KOO23915.1 - 5.1e-159 525.3 65.4 1e-51 175.0 5.8 4.6 4 0 0 4 4 4 4 Ion transport protein Tmemb_9 PF05434.6 KOO23915.1 - 0.037 13.7 0.2 4.4 7.0 0.0 3.1 2 0 0 2 2 2 0 TMEM9 DUF1510 PF07423.6 KOO23915.1 - 0.21 10.9 0.2 56 3.0 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1510) YL1 PF05764.8 KOO23915.1 - 0.26 10.8 0.0 0.26 10.8 0.0 1.6 2 0 0 2 2 2 0 YL1 nuclear protein Na_trans_assoc PF06512.8 KOO23915.1 - 0.42 10.5 6.4 2.8 7.8 0.1 3.3 3 1 0 3 3 3 0 Sodium ion transport-associated PKD_channel PF08016.7 KOO23915.1 - 3.9 5.7 91.4 0.14 10.5 1.3 11.4 10 2 1 12 12 12 0 Polycystin cation channel TTL PF03133.10 KOO23916.1 - 4.4e-30 104.6 0.0 2.7e-24 85.6 0.0 2.1 2 0 0 2 2 2 2 Tubulin-tyrosine ligase family ATP-grasp_3 PF02655.9 KOO23916.1 - 0.0012 18.7 0.0 1.6 8.5 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain ATP-grasp_4 PF13535.1 KOO23916.1 - 0.015 15.0 0.0 0.074 12.7 0.0 2.0 2 0 0 2 2 2 0 ATP-grasp domain RimK PF08443.6 KOO23916.1 - 0.069 12.6 0.0 6.2 6.2 0.0 2.2 2 0 0 2 2 2 0 RimK-like ATP-grasp domain ATPgrasp_YheCD PF14398.1 KOO23916.1 - 0.17 10.6 0.2 17 4.0 0.0 2.7 3 1 0 3 3 3 0 YheC/D like ATP-grasp IncA PF04156.9 KOO23919.1 - 2.1 7.8 50.5 1.2 8.7 1.2 4.2 2 1 2 4 4 4 0 IncA protein YrhK PF14145.1 KOO23921.1 - 1.2e-05 24.8 35.9 0.034 13.8 0.5 6.0 3 1 2 5 5 5 4 YrhK-like protein Ion_trans PF00520.26 KOO23922.1 - 6.2e-163 538.1 64.3 1.2e-45 155.2 4.0 4.3 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 KOO23922.1 - 3e-05 22.6 5.7 3e-05 22.6 3.9 8.9 7 3 3 10 10 10 6 Polycystin cation channel Methyltransf_PK PF05891.7 KOO23923.1 - 3.6e-60 202.9 0.0 6e-60 202.2 0.0 1.3 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Ank_5 PF13857.1 KOO23923.1 - 2e-20 72.3 1.3 5.8e-07 29.5 0.0 4.1 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO23923.1 - 1.6e-19 70.0 0.9 4.9e-14 52.4 0.2 3.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO23923.1 - 1.9e-15 55.8 1.8 0.00016 21.3 0.1 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 KOO23923.1 - 5.1e-13 49.1 1.0 4.7e-07 30.1 0.0 3.9 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO23923.1 - 3.2e-11 42.3 0.1 0.012 15.7 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Methyltransf_11 PF08241.7 KOO23923.1 - 2.2e-10 40.8 0.0 2.6e-05 24.6 0.0 3.0 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_18 PF12847.2 KOO23923.1 - 4.4e-10 40.1 0.0 1.9e-05 25.1 0.0 3.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_2 PF00891.13 KOO23923.1 - 1.1e-06 28.0 0.1 8.1e-05 21.9 0.0 2.8 2 1 0 3 3 3 1 O-methyltransferase Methyltransf_23 PF13489.1 KOO23923.1 - 2.3e-06 27.4 0.0 0.00047 19.9 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO23923.1 - 0.0029 18.0 0.0 0.047 14.1 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 KOO23923.1 - 0.0032 16.8 0.1 0.31 10.3 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_24 PF13578.1 KOO23923.1 - 0.016 16.0 0.1 0.41 11.5 0.0 3.4 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.1 KOO23923.1 - 0.018 15.4 0.0 0.099 13.0 0.0 2.4 3 0 0 3 3 2 0 Methyltransferase domain Methyltransf_26 PF13659.1 KOO23923.1 - 0.036 14.1 12.5 0.22 11.5 0.0 4.5 4 1 0 4 4 4 0 Methyltransferase domain DUF342 PF03961.8 KOO23923.1 - 0.67 8.3 3.2 0.99 7.7 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) PLAC8 PF04749.12 KOO23924.1 - 1.7e-16 60.7 4.5 4e-11 43.4 0.1 2.1 2 0 0 2 2 2 2 PLAC8 family CcmH PF03918.9 KOO23924.1 - 0.047 12.6 1.5 5.7 5.9 0.0 2.5 3 0 0 3 3 3 0 Cytochrome C biogenesis protein NR_Repeat PF14046.1 KOO23924.1 - 0.087 12.5 1.2 0.16 11.7 0.3 1.8 1 1 1 2 2 2 0 Nuclear receptor repeat Sel1 PF08238.7 KOO23926.1 - 5.5e-79 258.8 85.0 8.1e-09 35.8 1.8 11.0 11 0 0 11 11 11 10 Sel1 repeat TPR_10 PF13374.1 KOO23926.1 - 0.028 14.3 17.8 4.6 7.3 0.0 8.4 9 0 0 9 9 9 0 Tetratricopeptide repeat MOFRL PF05161.8 KOO23926.1 - 0.6 10.2 22.2 0.38 10.8 0.1 5.5 1 1 7 9 9 9 0 MOFRL family Herpes_U34 PF04541.8 KOO23926.1 - 0.85 8.4 3.6 53 2.6 0.0 4.3 2 1 3 7 7 7 0 Herpesvirus virion protein U34 ParD PF09386.5 KOO23926.1 - 6.3 6.9 17.3 35 4.5 0.1 6.1 5 2 3 8 8 8 0 Antitoxin ParD Peptidase_M18 PF02127.10 KOO23927.1 - 2.2e-140 468.0 0.0 2.9e-79 266.6 0.0 2.0 2 0 0 2 2 2 2 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.9 KOO23927.1 - 2.3e-06 26.6 0.0 0.00096 18.0 0.0 2.1 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase Peptidase_M20 PF01546.23 KOO23927.1 - 0.032 13.7 0.0 0.076 12.5 0.0 1.6 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 WD40 PF00400.27 KOO23928.1 - 2.1e-52 173.2 22.6 3.2e-10 39.5 0.0 11.6 12 0 0 12 12 12 8 WD domain, G-beta repeat PQQ_2 PF13360.1 KOO23928.1 - 8.9e-09 35.1 2.4 0.00015 21.2 0.2 3.7 2 2 2 4 4 4 2 PQQ-like domain Nup160 PF11715.3 KOO23928.1 - 6.3e-08 31.2 2.4 0.084 10.9 0.0 4.3 4 1 0 4 4 4 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.11 KOO23928.1 - 0.034 12.4 0.4 7 4.8 0.1 3.5 3 1 0 3 3 3 0 Cytochrome D1 heme domain NifZ PF04319.8 KOO23928.1 - 0.052 12.9 0.0 4.8 6.6 0.0 2.6 2 0 0 2 2 2 0 NifZ domain PQQ_3 PF13570.1 KOO23928.1 - 0.1 12.8 15.3 26 5.2 0.1 8.2 9 1 0 9 9 9 0 PQQ-like domain Hira PF07569.6 KOO23928.1 - 0.11 11.6 0.2 35 3.4 0.0 3.8 4 0 0 4 4 4 0 TUP1-like enhancer of split Nucleotid_trans PF03407.11 KOO23929.1 - 5.9e-33 114.4 0.1 1e-32 113.6 0.0 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase PDZ PF00595.19 KOO23930.1 - 0.017 15.2 0.0 0.029 14.5 0.0 1.3 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) Methyltransf_24 PF13578.1 KOO23931.1 - 9e-09 36.1 0.5 2.1e-08 34.9 0.2 1.7 2 0 0 2 2 2 1 Methyltransferase domain Ion_trans PF00520.26 KOO23932.1 - 5.6e-12 45.3 6.6 6.1e-11 41.9 4.5 2.6 1 1 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO23932.1 - 0.0061 16.2 1.9 0.016 14.8 1.3 1.7 1 0 0 1 1 1 1 Ion channel Ion_trans_N PF08412.5 KOO23932.1 - 0.024 13.9 0.1 0.069 12.4 0.1 1.7 1 0 0 1 1 1 0 Ion transport protein N-terminal His_Phos_1 PF00300.17 KOO23933.1 - 4.5e-25 88.5 0.0 8.1e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Zeta_toxin PF06414.7 KOO23933.1 - 1.7e-15 56.7 0.0 2.9e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.1 KOO23933.1 - 6.3e-09 35.8 0.0 1.2e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO23933.1 - 2.2e-06 28.4 0.1 0.00021 22.1 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.1 KOO23933.1 - 0.1 12.9 0.1 0.38 11.0 0.1 2.0 1 1 1 2 2 2 0 AAA domain Viral_helicase1 PF01443.13 KOO23933.1 - 0.12 11.9 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.1 KOO23933.1 - 0.16 12.1 0.0 0.46 10.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain DUF3421 PF11901.3 KOO23935.1 - 3.3e-07 30.0 0.1 0.12 12.0 0.0 4.7 4 1 1 5 5 5 2 Protein of unknown function (DUF3421) Cupin_3 PF05899.7 KOO23935.1 - 0.0019 17.5 0.1 0.1 12.0 0.0 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF861) Synaptobrevin PF00957.16 KOO23935.1 - 0.025 14.1 0.5 0.043 13.4 0.3 1.3 1 0 0 1 1 1 0 Synaptobrevin EF-hand_1 PF00036.27 KOO23936.1 - 6e-34 112.7 11.0 4.5e-09 34.9 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO23936.1 - 5e-28 97.0 9.4 1.4e-15 57.1 0.3 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO23936.1 - 4.3e-26 88.4 10.1 4.6e-09 35.3 0.0 4.9 4 2 1 5 5 5 4 EF-hand domain EF-hand_8 PF13833.1 KOO23936.1 - 1.2e-25 88.8 11.3 2.8e-12 46.0 0.2 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO23936.1 - 1.1e-23 81.4 9.1 3.4e-06 26.1 0.2 4.7 4 1 1 5 5 5 4 EF hand EF-hand_9 PF14658.1 KOO23936.1 - 6.2e-13 48.4 0.1 4.4e-07 29.7 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 KOO23936.1 - 2e-06 27.4 4.0 0.15 11.8 0.6 3.6 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO23936.1 - 0.0014 18.6 0.1 1.4 8.9 0.0 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region LETM1 PF07766.8 KOO23936.1 - 0.011 14.8 0.2 0.014 14.4 0.1 1.3 1 0 0 1 1 1 0 LETM1-like protein Caleosin PF05042.8 KOO23936.1 - 0.012 15.1 0.1 5.3 6.5 0.0 2.5 2 1 0 2 2 2 0 Caleosin related protein Toprim_2 PF13155.1 KOO23936.1 - 0.016 15.5 1.9 5 7.5 0.0 2.4 1 1 1 2 2 2 0 Toprim-like Acetyltransf_11 PF13720.1 KOO23936.1 - 0.038 14.2 0.3 1.9 8.7 0.0 2.4 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 OST-HTH PF12872.2 KOO23936.1 - 0.046 13.5 0.0 15 5.5 0.0 3.1 3 1 1 4 4 4 0 OST-HTH/LOTUS domain PMBR PF09373.5 KOO23936.1 - 0.084 12.8 0.2 18 5.4 0.0 4.4 6 0 0 6 6 6 0 Pseudomurein-binding repeat TyeA PF09059.5 KOO23936.1 - 0.093 12.6 0.1 0.41 10.5 0.0 1.9 2 0 0 2 2 2 0 TyeA DUF21 PF01595.15 KOO23936.1 - 0.099 11.9 0.2 0.66 9.2 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF21 DUF3008 PF11450.3 KOO23936.1 - 0.099 12.7 0.2 0.099 12.7 0.1 3.2 4 0 0 4 4 4 0 Protein of unknwon function (DUF3008) UPF0154 PF03672.8 KOO23936.1 - 0.1 12.1 0.5 9.6 5.9 0.0 3.3 4 0 0 4 4 4 0 Uncharacterised protein family (UPF0154) DUF4373 PF14297.1 KOO23936.1 - 0.23 11.7 1.8 53 4.2 0.1 3.3 1 1 3 4 4 4 0 Domain of unknown function (DUF4373) EF-hand_10 PF14788.1 KOO23936.1 - 0.5 10.0 3.1 8.7 6.1 0.2 2.9 2 1 1 3 3 3 0 EF hand Endonuc-dimeris PF09124.5 KOO23936.1 - 0.7 9.5 3.7 12 5.5 0.0 2.9 3 0 0 3 3 3 0 T4 recombination endonuclease VII, dimerisation DUF2757 PF10955.3 KOO23936.1 - 1.6 9.0 3.3 31 4.8 0.2 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2757) EF-hand_8 PF13833.1 KOO23937.1 - 0.0059 16.1 0.3 0.22 11.1 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.1 KOO23937.1 - 0.43 10.7 1.5 5.4 7.2 0.0 3.0 3 0 0 3 3 3 0 EF-hand domain pair EF-hand_7 PF13499.1 KOO23938.1 - 4.5e-07 29.8 0.0 1.7e-06 28.0 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO23938.1 - 7.8e-06 25.3 0.9 0.00036 20.1 0.1 3.0 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.27 KOO23938.1 - 0.00017 20.6 0.1 0.0062 15.7 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.1 KOO23938.1 - 0.0039 16.4 0.5 0.33 10.3 0.1 2.5 2 0 0 2 2 2 1 EF hand HTH_15 PF12324.3 KOO23938.1 - 0.098 12.3 0.4 2.4 7.8 0.0 2.8 2 0 0 2 2 2 0 Helix-turn-helix domain of alkylmercury lyase DnaB_bind PF10410.4 KOO23938.1 - 0.21 11.5 1.9 0.45 10.5 0.2 2.5 2 0 0 2 2 2 0 DnaB-helicase binding domain of primase Methyltransf_11 PF08241.7 KOO23939.1 - 1e-22 80.4 0.0 1.5e-22 79.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO23939.1 - 5.1e-18 65.0 0.0 1.4e-16 60.2 0.0 2.0 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 KOO23939.1 - 3.4e-17 62.4 0.0 4.4e-17 62.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO23939.1 - 1.1e-14 54.5 0.0 1.9e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO23939.1 - 6e-13 48.8 0.0 8.5e-13 48.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO23939.1 - 1.2e-12 48.4 0.0 2.1e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO23939.1 - 5.8e-12 45.9 0.0 8.8e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO23939.1 - 2.4e-09 37.2 0.1 4.8e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOO23939.1 - 1e-07 31.4 0.0 1.6e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain RrnaAD PF00398.15 KOO23939.1 - 1e-05 24.7 0.0 1.4e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase CMAS PF02353.15 KOO23939.1 - 0.0045 16.1 0.0 0.0064 15.5 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase GidB PF02527.10 KOO23939.1 - 0.0067 15.5 0.0 0.0095 15.0 0.0 1.2 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G MetW PF07021.7 KOO23939.1 - 0.013 14.9 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW ADH_zinc_N PF00107.21 KOO23939.1 - 0.053 13.0 0.1 11 5.6 0.0 2.2 2 0 0 2 2 2 0 Zinc-binding dehydrogenase Cons_hypoth95 PF03602.10 KOO23939.1 - 0.053 12.9 0.0 0.081 12.3 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PrmA PF06325.8 KOO23939.1 - 0.096 11.7 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.14 KOO23939.1 - 0.13 11.8 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_16 PF10294.4 KOO23939.1 - 0.17 11.2 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase PTEN_C2 PF10409.4 KOO23940.1 - 5.3e-13 48.8 0.0 8.8e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein Gln-synt_C PF00120.19 KOO23941.1 - 6.3e-73 245.1 0.0 7.9e-73 244.7 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.14 KOO23941.1 - 0.0029 17.1 0.0 0.0061 16.1 0.0 1.5 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain ABC2_membrane PF01061.19 KOO23942.1 - 1.2e-30 106.2 22.9 1.2e-30 106.2 15.9 1.6 2 0 0 2 2 1 1 ABC-2 type transporter ABC_tran PF00005.22 KOO23942.1 - 1e-23 84.1 0.0 1.4e-23 83.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 KOO23942.1 - 3.2e-09 37.1 0.0 3.8e-07 30.3 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 KOO23942.1 - 2.9e-05 23.4 0.2 7.6e-05 22.1 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.1 KOO23942.1 - 8.7e-05 22.5 0.0 0.00015 21.8 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.14 KOO23942.1 - 0.00011 21.5 0.0 0.00029 20.1 0.0 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_25 PF13481.1 KOO23942.1 - 0.00031 20.1 0.1 0.0005 19.5 0.1 1.4 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 KOO23942.1 - 0.00038 19.4 0.2 0.0022 16.9 0.0 1.9 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_19 PF13245.1 KOO23942.1 - 0.003 17.2 0.1 0.0077 15.9 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_23 PF13476.1 KOO23942.1 - 0.0046 17.2 0.2 0.0076 16.5 0.2 1.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KOO23942.1 - 0.0086 16.2 0.0 0.021 14.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO23942.1 - 0.012 16.4 0.0 0.026 15.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 KOO23942.1 - 0.014 15.1 0.0 0.067 12.9 0.0 2.0 2 0 0 2 2 2 0 NTPase NACHT PF05729.7 KOO23942.1 - 0.014 15.0 0.0 0.024 14.2 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA PF00004.24 KOO23942.1 - 0.017 15.3 0.0 0.037 14.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 KOO23942.1 - 0.039 13.8 0.0 0.069 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 KOO23942.1 - 0.04 13.3 0.1 0.071 12.5 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF258 PF03193.11 KOO23942.1 - 0.044 12.9 0.1 0.078 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_30 PF13604.1 KOO23942.1 - 0.047 13.2 0.1 0.087 12.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 KOO23942.1 - 0.055 13.1 0.1 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Arch_ATPase PF01637.13 KOO23942.1 - 0.065 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase AAA_18 PF13238.1 KOO23942.1 - 0.096 12.9 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 KOO23942.1 - 0.13 11.6 0.1 0.21 10.9 0.1 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_28 PF13521.1 KOO23942.1 - 0.18 11.7 0.1 0.34 10.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain UPF0079 PF02367.12 KOO23942.1 - 0.21 11.2 0.2 0.37 10.4 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 NB-ARC PF00931.17 KOO23942.1 - 0.22 10.3 0.0 0.33 9.7 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain PDR_CDR PF06422.7 KOO23942.1 - 1.7 8.3 6.7 0.16 11.6 0.2 2.4 2 1 1 3 3 3 0 CDR ABC transporter Abhydrolase_6 PF12697.2 KOO23943.1 - 6.3e-16 58.9 6.8 6.3e-16 58.9 4.7 2.4 2 1 0 2 2 2 1 Alpha/beta hydrolase family Epimerase PF01370.16 KOO23943.1 - 6.3e-09 35.6 0.1 6.5e-08 32.2 0.1 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Abhydrolase_1 PF00561.15 KOO23943.1 - 2.3e-06 27.3 0.1 3.9e-05 23.3 0.0 2.3 1 1 0 2 2 2 1 alpha/beta hydrolase fold NAD_binding_4 PF07993.7 KOO23943.1 - 3.8e-05 22.7 0.0 0.00012 21.1 0.0 1.7 2 0 0 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.10 KOO23943.1 - 0.00037 19.4 0.0 0.086 11.7 0.0 2.1 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein PhyH PF05721.8 KOO23944.1 - 7.4e-23 81.6 0.0 1e-22 81.1 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_3 PF13640.1 KOO23944.1 - 0.04 14.4 0.0 0.16 12.5 0.0 2.0 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily TipAS PF07739.8 KOO23945.1 - 0.012 15.9 0.0 0.036 14.3 0.0 1.8 1 0 0 1 1 1 0 TipAS antibiotic-recognition domain CorC_HlyC PF03471.12 KOO23946.1 - 0.067 12.9 0.0 0.067 12.9 0.0 1.1 1 0 0 1 1 1 0 Transporter associated domain NfeD PF01957.13 KOO23948.1 - 0.0059 16.7 0.6 0.0082 16.2 0.4 1.3 1 0 0 1 1 1 1 NfeD-like C-terminal, partner-binding PI3_PI4_kinase PF00454.22 KOO23949.1 - 3.1e-43 147.9 0.0 4.5e-43 147.4 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.15 KOO23949.1 - 9.9e-13 47.2 0.0 1.9e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 FATC domain Atg14 PF10186.4 KOO23950.1 - 8.7 5.1 28.6 1.3 7.8 12.2 2.4 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 EF-hand_1 PF00036.27 KOO23951.1 - 4e-36 119.5 20.3 5.4e-10 37.8 1.2 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO23951.1 - 1.4e-30 105.2 12.1 1.2e-17 63.8 0.6 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO23951.1 - 3.7e-29 97.9 12.3 8.9e-10 37.6 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 KOO23951.1 - 2.4e-28 97.4 18.6 1.3e-13 50.3 1.1 3.8 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO23951.1 - 6.8e-24 82.0 20.0 8e-07 28.1 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.1 KOO23951.1 - 4.7e-16 58.4 0.2 2.5e-07 30.5 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 KOO23951.1 - 5.4e-07 29.3 9.3 0.06 13.0 0.6 3.3 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO23951.1 - 0.0005 20.0 1.0 0.31 11.0 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region PMBR PF09373.5 KOO23951.1 - 0.0091 15.9 0.9 39 4.4 0.0 4.6 5 0 0 5 5 5 0 Pseudomurein-binding repeat DUF853 PF05872.7 KOO23951.1 - 0.011 14.1 0.4 0.72 8.1 0.0 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF853) TerB PF05099.8 KOO23951.1 - 0.015 15.0 3.9 0.064 12.9 0.1 2.6 1 1 1 3 3 3 0 Tellurite resistance protein TerB UPF0154 PF03672.8 KOO23951.1 - 0.028 14.0 0.2 17 5.1 0.0 3.1 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0154) FlgD PF03963.9 KOO23951.1 - 0.032 14.2 1.7 0.18 11.8 0.3 2.2 2 1 0 2 2 2 0 Flagellar hook capping protein - N-terminal region DUF21 PF01595.15 KOO23951.1 - 0.048 12.9 1.5 0.37 10.0 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF21 Glyco_transf_92 PF01697.22 KOO23951.1 - 0.062 12.6 0.3 0.09 12.0 0.2 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 92 Phg_2220_C PF09524.5 KOO23951.1 - 0.064 13.2 0.6 8.3 6.4 0.1 2.2 1 1 1 2 2 2 0 Conserved phage C-terminus (Phg_2220_C) EF-hand_10 PF14788.1 KOO23951.1 - 0.067 12.8 6.3 0.38 10.4 0.9 3.2 3 1 1 4 4 4 0 EF hand Caleosin PF05042.8 KOO23951.1 - 0.099 12.1 0.3 1.1 8.8 0.2 2.4 1 1 0 1 1 1 0 Caleosin related protein Toprim_2 PF13155.1 KOO23951.1 - 0.13 12.6 4.5 5.7 7.3 0.2 2.4 1 1 1 2 2 2 0 Toprim-like LETM1 PF07766.8 KOO23951.1 - 0.17 10.8 1.9 0.26 10.2 1.3 1.4 1 1 0 1 1 1 0 LETM1-like protein DUF892 PF05974.7 KOO23951.1 - 0.29 10.9 3.1 1.3 8.7 0.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF892) DUF4373 PF14297.1 KOO23951.1 - 0.31 11.3 3.1 41 4.5 0.0 3.3 1 1 3 4 4 4 0 Domain of unknown function (DUF4373) DUF3008 PF11450.3 KOO23951.1 - 0.35 11.0 0.2 0.35 11.0 0.1 3.3 4 0 0 4 4 4 0 Protein of unknwon function (DUF3008) MgtE_N PF03448.12 KOO23951.1 - 0.71 10.2 6.3 0.14 12.4 0.9 2.3 3 0 0 3 3 2 0 MgtE intracellular N domain Ribosomal_L31e PF01198.14 KOO23953.1 - 6e-38 128.3 0.8 7.8e-38 128.0 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e Mqo PF06039.10 KOO23955.1 - 5.8e-123 410.6 0.0 8e-123 410.1 0.0 1.1 1 0 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) EF-hand_7 PF13499.1 KOO23955.1 - 3.2e-11 43.1 0.1 6.3e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO23955.1 - 4.1e-10 38.5 0.1 0.00015 20.9 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO23955.1 - 1.4e-09 37.3 0.3 7.2e-06 25.5 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO23955.1 - 1.4e-08 33.4 0.3 0.0015 17.6 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO23955.1 - 2.4e-08 33.1 0.2 0.0067 16.2 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain DAO PF01266.19 KOO23955.1 - 5.3e-08 32.1 0.0 8.1e-08 31.5 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GSH_synth_ATP PF03917.12 KOO23956.1 - 1.1e-99 333.4 0.0 4.4e-61 206.5 0.0 2.0 1 1 1 2 2 2 2 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.10 KOO23956.1 - 2.7e-30 104.5 0.0 7.4e-30 103.1 0.0 1.8 1 0 0 1 1 1 1 Eukaryotic glutathione synthase CP_ATPgrasp_2 PF14403.1 KOO23956.1 - 0.016 13.8 0.0 0.027 13.1 0.0 1.3 1 0 0 1 1 1 0 Circularly permuted ATP-grasp type 2 PP2C PF00481.16 KOO23957.1 - 2.6e-20 72.9 0.0 1e-19 70.9 0.0 1.9 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 KOO23957.1 - 3.7e-08 33.0 5.8 5.2e-08 32.5 0.1 2.8 3 0 0 3 3 3 1 Protein phosphatase 2C Mitofilin PF09731.4 KOO23957.1 - 0.057 12.0 10.1 0.086 11.4 7.0 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein TIG PF01833.19 KOO23959.1 - 4.7e-44 148.3 34.4 4e-11 42.7 0.1 6.5 6 0 0 6 6 6 5 IPT/TIG domain G8 PF10162.4 KOO23959.1 - 1.1e-30 106.0 0.0 1.6e-20 73.1 0.0 2.9 2 0 0 2 2 2 2 G8 domain Beta_helix PF13229.1 KOO23959.1 - 6e-05 22.8 21.4 0.18 11.5 0.0 6.1 3 2 0 3 3 3 1 Right handed beta helix region F5_F8_type_C PF00754.20 KOO23959.1 - 0.00032 20.5 0.0 0.00076 19.3 0.0 1.6 1 0 0 1 1 1 1 F5/8 type C domain TPR_11 PF13414.1 KOO23961.1 - 2.2e-05 23.9 0.4 2.2e-05 23.9 0.3 1.7 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.12 KOO23961.1 - 0.00075 19.2 0.3 0.00075 19.2 0.2 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO23961.1 - 0.0014 18.1 0.3 0.0026 17.2 0.2 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO23961.1 - 0.052 14.2 0.3 0.052 14.2 0.2 2.2 2 1 0 2 2 2 0 Tetratricopeptide repeat CBM_17_28 PF03424.9 KOO23961.1 - 0.11 12.0 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Carbohydrate binding domain (family 17/28) MIT PF04212.13 KOO23961.1 - 0.42 10.5 6.0 2.1 8.2 0.1 2.3 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 KOO23962.1 - 1.5e-09 37.3 0.2 4.4e-05 23.0 0.1 3.4 3 0 0 3 3 3 2 TPR repeat TPR_1 PF00515.23 KOO23962.1 - 2.8e-06 26.6 2.9 0.0028 17.1 0.1 3.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO23962.1 - 3.4e-06 26.5 8.4 0.009 15.8 0.1 3.6 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO23962.1 - 3.6e-05 24.0 2.9 0.0043 17.5 0.1 4.6 3 1 1 4 4 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO23962.1 - 0.00014 21.3 0.1 0.82 9.5 0.0 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO23962.1 - 0.0023 17.8 0.2 0.0023 17.8 0.2 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO23962.1 - 0.0054 17.0 3.0 1.5 9.2 0.1 3.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.1 KOO23962.1 - 0.0078 15.3 0.1 0.033 13.2 0.0 2.0 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO23962.1 - 0.018 15.6 7.9 0.095 13.4 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3856 PF12968.2 KOO23962.1 - 0.062 13.1 0.6 1.2 8.9 0.4 2.5 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) TPR_17 PF13431.1 KOO23962.1 - 0.068 13.4 0.9 7.6 7.0 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Apc3 PF12895.2 KOO23962.1 - 0.17 11.9 1.3 0.83 9.8 0.9 2.2 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 KOO23962.1 - 1.7 8.5 9.2 0.11 12.3 0.9 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat UBA PF00627.26 KOO23963.1 - 1.1e-07 31.4 0.4 2.4e-07 30.3 0.3 1.6 1 0 0 1 1 1 1 UBA/TS-N domain zf-RING_2 PF13639.1 KOO23963.1 - 6.6e-05 22.6 3.7 0.0002 21.0 2.6 1.8 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.1 KOO23963.1 - 0.0031 17.1 1.4 0.007 16.0 1.0 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) UIM PF02809.15 KOO23963.1 - 0.0031 16.9 1.7 0.014 14.9 1.2 2.2 1 0 0 1 1 1 1 Ubiquitin interaction motif CUE PF02845.11 KOO23963.1 - 0.012 15.1 0.1 0.021 14.3 0.0 1.4 1 0 0 1 1 1 0 CUE domain zf-RING_5 PF14634.1 KOO23963.1 - 0.044 13.5 2.5 0.11 12.2 1.7 1.7 1 1 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 KOO23963.1 - 0.088 12.8 2.9 0.31 11.0 2.1 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO23963.1 - 0.58 9.8 3.1 0.34 10.6 0.6 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Asp PF00026.18 KOO23964.1 - 2.6e-25 89.3 0.0 9.7e-25 87.4 0.0 1.9 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 KOO23964.1 - 0.0011 18.9 0.4 0.0041 17.0 0.0 2.1 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal zinc_ribbon_2 PF13240.1 KOO23964.1 - 0.063 12.7 0.1 0.15 11.6 0.1 1.7 1 0 0 1 1 1 0 zinc-ribbon domain Mannosyl_trans2 PF04188.8 KOO23965.1 - 3.1e-33 115.3 2.6 3.4e-33 115.2 1.8 1.0 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V)) EF-hand_1 PF00036.27 KOO23966.1 - 5.7e-34 112.8 1.1 0.00012 21.0 0.0 6.2 6 0 0 6 6 6 6 EF hand EF-hand_5 PF13202.1 KOO23966.1 - 4.7e-33 111.0 3.6 3.4e-05 22.9 0.0 6.2 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.1 KOO23966.1 - 8.6e-31 103.0 1.4 0.0015 18.2 0.0 6.4 6 0 0 6 6 6 6 EF-hand domain EF-hand_7 PF13499.1 KOO23966.1 - 1.9e-28 98.3 0.1 1.6e-08 34.5 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO23966.1 - 4.2e-20 71.1 10.1 0.0063 16.1 0.0 6.5 4 3 3 7 7 7 6 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO23966.1 - 1.2e-09 38.1 0.0 0.029 14.4 0.0 3.7 3 1 0 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region Toprim PF01751.17 KOO23966.1 - 1.8e-05 24.6 0.2 0.86 9.6 0.0 3.2 1 1 1 2 2 2 2 Toprim domain TPR_20 PF14561.1 KOO23966.1 - 0.0018 18.3 2.0 0.32 11.1 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat EF-hand_9 PF14658.1 KOO23966.1 - 0.014 15.3 0.3 1.8 8.5 0.0 3.5 4 0 0 4 4 4 0 EF-hand domain Caleosin PF05042.8 KOO23966.1 - 0.09 12.3 0.1 5 6.6 0.0 3.3 3 2 1 4 4 4 0 Caleosin related protein Dockerin_1 PF00404.13 KOO23966.1 - 7 6.5 16.6 12 5.8 0.3 4.6 4 0 0 4 4 4 0 Dockerin type I repeat MtN3_slv PF03083.11 KOO23967.1 - 1.4e-36 124.2 10.9 2.3e-22 78.6 2.5 2.3 2 0 0 2 2 2 2 Sugar efflux transporter for intercellular exchange AgrB PF04647.10 KOO23967.1 - 1.5 7.8 11.4 1.5 7.8 0.2 2.6 2 1 1 3 3 3 0 Accessory gene regulator B SNF2_N PF00176.18 KOO23969.1 - 9.9e-78 260.9 0.2 2e-77 259.9 0.2 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.5 KOO23969.1 - 1.1e-26 92.8 0.0 2.4e-26 91.8 0.0 1.6 1 0 0 1 1 1 1 SLIDE Helicase_C PF00271.26 KOO23969.1 - 4.4e-16 58.5 0.0 1.4e-15 56.9 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO23969.1 - 2.3e-08 34.0 0.0 7.2e-08 32.4 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HAND PF09110.6 KOO23969.1 - 2.3e-06 27.9 0.6 2.3e-06 27.9 0.4 2.5 2 1 0 2 2 2 1 HAND HDA2-3 PF11496.3 KOO23969.1 - 1.7e-05 23.7 0.0 5.2e-05 22.2 0.0 1.7 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.24 KOO23969.1 - 4.4e-05 23.0 0.0 0.00012 21.6 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase DBINO PF13892.1 KOO23969.1 - 0.013 15.5 4.0 0.013 15.5 2.7 2.3 2 0 0 2 2 2 0 DNA-binding domain DEAD_2 PF06733.10 KOO23969.1 - 0.069 12.5 0.7 0.24 10.7 0.0 2.0 2 0 0 2 2 2 0 DEAD_2 AAA_22 PF13401.1 KOO23969.1 - 0.076 13.1 0.0 0.26 11.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain ATP11 PF06644.6 KOO23970.1 - 1.5e-05 24.6 0.0 1.7e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 ATP11 protein XRN_N PF03159.13 KOO23972.1 - 1.1e-75 254.0 0.0 1.5e-75 253.6 0.0 1.2 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus HCaRG PF07258.9 KOO23973.1 - 1.1e-17 64.0 0.0 1.4e-17 63.8 0.0 1.1 1 0 0 1 1 1 1 HCaRG protein FNIP_C PF14638.1 KOO23973.1 - 0.014 14.7 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 Folliculin-interacting protein C-terminus 2OG-FeII_Oxy PF03171.15 KOO23974.1 - 0.00089 19.5 0.0 0.0019 18.4 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SF3b1 PF08920.5 KOO23974.1 - 0.12 12.3 2.8 0.37 10.7 0.0 2.4 2 0 0 2 2 2 0 Splicing factor 3B subunit 1 WD40 PF00400.27 KOO23975.1 - 9.3e-24 82.3 5.8 3.3e-07 29.9 0.1 5.2 5 0 0 5 5 5 5 WD domain, G-beta repeat eIF2A PF08662.6 KOO23975.1 - 3e-05 23.8 0.0 6.8e-05 22.6 0.0 1.4 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 KOO23975.1 - 0.0013 17.0 0.4 4.2 5.3 0.0 3.3 1 1 2 3 3 3 3 Nucleoporin Nup120/160 TruB_C PF09142.6 KOO23975.1 - 0.14 11.8 1.1 13 5.5 0.0 3.7 4 0 0 4 4 4 0 tRNA Pseudouridine synthase II, C terminal TPR_11 PF13414.1 KOO23976.1 - 5.3e-16 58.0 6.5 5.5e-15 54.7 2.6 3.8 4 0 0 4 4 4 2 TPR repeat TPR_2 PF07719.12 KOO23976.1 - 8e-15 53.4 12.3 3.9e-05 23.2 1.0 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO23976.1 - 1.5e-12 46.5 2.7 0.0002 20.8 0.4 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat DnaJ PF00226.26 KOO23976.1 - 3.9e-12 45.7 0.3 1.2e-11 44.2 0.1 1.8 2 0 0 2 2 2 1 DnaJ domain TPR_17 PF13431.1 KOO23976.1 - 1.9e-08 33.8 3.5 0.0026 17.8 0.0 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO23976.1 - 5.9e-07 28.8 0.1 0.2 11.5 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO23976.1 - 2.2e-05 24.9 20.3 5.3e-05 23.7 5.1 5.7 3 3 2 5 5 4 3 Tetratricopeptide repeat TPR_9 PF13371.1 KOO23976.1 - 0.0027 17.5 19.6 0.046 13.5 4.0 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO23976.1 - 0.012 15.5 7.9 0.017 15.0 2.5 3.1 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO23976.1 - 0.042 14.4 0.2 0.042 14.4 0.1 6.6 3 3 4 7 7 6 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO23976.1 - 0.073 12.9 0.1 0.073 12.9 0.1 4.5 5 0 0 5 5 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO23976.1 - 0.88 9.4 4.8 4.2 7.3 0.1 3.2 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat PhageMin_Tail PF10145.4 KOO23976.1 - 3.4 7.2 10.0 0.043 13.4 1.0 2.2 3 1 1 4 4 4 0 Phage-related minor tail protein BTAD PF03704.12 KOO23976.1 - 5.6 7.2 24.8 0.035 14.4 3.7 3.7 3 2 1 4 4 4 0 Bacterial transcriptional activator domain RHD3 PF05879.7 KOO23977.1 - 1.8e-10 39.4 0.0 6e-09 34.4 0.0 2.6 1 1 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) FAD_binding_6 PF00970.19 KOO23978.1 - 7.6e-09 35.6 0.0 1.2e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 KOO23978.1 - 7.9e-08 32.8 0.1 2.8e-07 31.0 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 KOO23978.1 - 0.0032 17.3 0.1 0.049 13.5 0.0 2.1 2 0 0 2 2 2 1 Ferric reductase NAD binding domain DUF1180 PF06679.7 KOO23978.1 - 0.11 12.3 5.8 2.8 7.7 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) OmpH PF03938.9 KOO23979.1 - 0.0083 16.0 11.1 0.0083 16.0 7.7 1.5 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) NPV_P10 PF05531.7 KOO23979.1 - 0.052 13.8 3.7 0.14 12.4 1.3 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Filament PF00038.16 KOO23979.1 - 0.059 12.8 7.9 0.099 12.0 5.5 1.3 1 0 0 1 1 1 0 Intermediate filament protein DUF3138 PF11336.3 KOO23979.1 - 0.068 11.3 7.2 0.022 12.9 3.1 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) SCP2_2 PF13530.1 KOO23979.1 - 0.071 12.4 2.6 0.093 12.1 1.5 1.4 1 1 0 1 1 1 0 Sterol carrier protein domain Spc24 PF08286.6 KOO23979.1 - 0.25 11.0 3.7 0.55 9.9 2.5 1.6 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DUF4610 PF15384.1 KOO23979.1 - 0.25 10.8 5.9 7.1 6.1 2.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4610) BBP1_C PF15272.1 KOO23979.1 - 0.38 10.2 3.2 0.63 9.5 2.2 1.3 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal DUF3373 PF11853.3 KOO23979.1 - 0.45 8.9 6.0 0.7 8.3 4.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3373) APG6 PF04111.7 KOO23979.1 - 1.1 8.3 9.2 1.5 7.8 6.4 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 YscO PF07321.7 KOO23979.1 - 1.3 8.7 18.2 0.14 12.0 9.2 1.8 3 0 0 3 3 3 0 Type III secretion protein YscO Fez1 PF06818.10 KOO23979.1 - 1.8 8.5 12.0 2.5 8.0 8.3 1.3 1 1 0 1 1 1 0 Fez1 2Fe-2S_thioredx PF01257.14 KOO23980.1 - 1.1e-51 174.2 0.7 2.5e-48 163.3 0.1 2.1 2 0 0 2 2 2 2 Thioredoxin-like [2Fe-2S] ferredoxin FAST_1 PF06743.10 KOO23981.1 - 0.016 14.8 0.1 0.14 11.8 0.0 2.6 3 0 0 3 3 3 0 FAST kinase-like protein, subdomain 1 DUF3886 PF13025.1 KOO23981.1 - 0.09 12.7 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3886) Glyco_hydro_10 PF00331.15 KOO23982.1 - 7.9e-11 41.5 0.0 1.4e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 CBM_4_9 PF02018.12 KOO23982.1 - 1.7e-08 34.5 0.2 0.0045 17.0 0.0 3.2 3 0 0 3 3 3 2 Carbohydrate binding domain LRR_6 PF13516.1 KOO23984.1 - 4.2e-08 32.4 0.0 0.5 10.5 0.0 3.9 4 0 0 4 4 4 3 Leucine Rich repeat LRR_7 PF13504.1 KOO23984.1 - 0.011 15.7 0.6 33 5.3 0.0 3.9 4 0 0 4 4 4 0 Leucine rich repeat LRR_4 PF12799.2 KOO23984.1 - 0.028 14.0 0.0 2.2 8.0 0.0 2.9 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO23984.1 - 0.031 14.2 0.0 72 4.0 0.0 3.7 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_8 PF13855.1 KOO23984.1 - 0.13 12.0 0.0 2.1 8.1 0.0 2.7 3 1 0 3 3 3 0 Leucine rich repeat CTP_transf_1 PF01148.15 KOO23985.1 - 2.7e-51 174.7 25.5 2.2e-50 171.7 17.7 1.9 1 1 0 1 1 1 1 Cytidylyltransferase family AAA_16 PF13191.1 KOO23986.1 - 0.0031 17.5 0.0 0.0093 15.9 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain Methyltransf_16 PF10294.4 KOO23987.1 - 4.1e-16 58.9 0.0 5.2e-16 58.5 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.9 KOO23987.1 - 2.9e-07 29.9 0.1 5e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.2 KOO23987.1 - 5.5e-06 26.9 0.1 8.7e-06 26.2 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 KOO23987.1 - 0.00068 18.8 0.1 0.00089 18.4 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Met_10 PF02475.11 KOO23987.1 - 0.00081 19.0 0.0 0.0011 18.5 0.0 1.1 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_26 PF13659.1 KOO23987.1 - 0.0024 17.8 0.3 0.0032 17.4 0.2 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO23987.1 - 0.02 14.6 0.0 0.029 14.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.10 KOO23987.1 - 0.031 13.6 0.1 0.042 13.2 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Arm PF00514.18 KOO23989.1 - 4.7e-32 108.7 113.7 0.0015 18.3 0.0 27.6 32 0 0 32 32 32 13 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO23989.1 - 4.2e-10 39.7 136.6 0.00065 19.9 4.6 17.6 7 5 8 16 16 16 9 HEAT repeats Arm_2 PF04826.8 KOO23989.1 - 1.8e-06 27.2 0.0 4.4 6.3 0.0 6.7 7 1 1 8 8 8 2 Armadillo-like Cnd1 PF12717.2 KOO23989.1 - 0.0056 16.5 0.1 0.37 10.6 0.0 4.0 4 1 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.15 KOO23989.1 - 0.018 13.4 9.6 0.76 8.0 0.0 5.5 5 1 0 5 5 5 0 Adaptin N terminal region RTTN_N PF14726.1 KOO23989.1 - 0.018 15.6 4.7 25 5.5 0.1 6.4 6 1 0 7 7 7 0 Rotatin, an armadillo repeat protein, centriole functioning Proteasom_PSMB PF10508.4 KOO23989.1 - 0.02 13.2 9.2 3.9 5.6 0.0 6.2 6 2 0 6 6 6 0 Proteasome non-ATPase 26S subunit CLASP_N PF12348.3 KOO23989.1 - 0.024 13.9 0.4 0.92 8.8 0.0 3.7 3 0 0 3 3 3 0 CLASP N terminal SprB PF13573.1 KOO23989.1 - 0.44 10.1 0.0 1.2 8.7 0.0 1.7 1 0 0 1 1 1 0 SprB repeat RPE65 PF03055.10 KOO23990.1 - 2.5e-35 122.0 0.0 8e-19 67.5 0.0 2.0 1 1 1 2 2 2 2 Retinal pigment epithelial membrane protein TPR_11 PF13414.1 KOO23991.1 - 8.9e-13 47.6 8.4 8.6e-08 31.7 1.8 2.5 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 KOO23991.1 - 1.8e-11 43.1 1.4 5.2e-05 22.6 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO23991.1 - 3.6e-10 38.9 3.8 2e-05 24.1 0.2 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO23991.1 - 2.7e-07 31.0 6.3 2.8e-06 27.8 1.3 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat DUF3846 PF12957.2 KOO23991.1 - 6.3e-06 25.8 0.0 1.4e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3846) TPR_19 PF14559.1 KOO23991.1 - 0.00017 21.8 4.4 0.00048 20.4 1.2 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO23991.1 - 0.00045 20.6 7.4 0.0068 16.9 0.4 4.0 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOO23991.1 - 0.0013 18.4 3.9 0.0041 16.9 2.7 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOO23991.1 - 0.0039 17.0 5.0 0.006 16.4 0.8 2.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO23991.1 - 0.081 12.7 0.2 0.31 10.9 0.1 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat Apc3 PF12895.2 KOO23991.1 - 0.1 12.7 3.7 0.37 10.9 0.4 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.12 KOO23991.1 - 0.1 12.8 5.0 0.29 11.4 3.1 2.1 1 1 0 1 1 1 0 Bacterial transcriptional activator domain TPR_6 PF13174.1 KOO23991.1 - 0.18 12.3 1.8 19 5.9 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat PUB PF09409.5 KOO23993.1 - 0.0021 17.7 0.0 0.0043 16.7 0.0 1.4 1 0 0 1 1 1 1 PUB domain ELMO_CED12 PF04727.8 KOO23994.1 - 8.3e-40 136.1 0.0 1.5e-39 135.2 0.0 1.5 1 0 0 1 1 1 1 ELMO/CED-12 family Sod_Fe_C PF02777.13 KOO23994.1 - 0.0085 15.9 0.0 0.021 14.6 0.0 1.6 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Ribosomal_S30AE PF02482.14 KOO23994.1 - 0.049 14.0 0.2 0.13 12.6 0.2 1.7 1 0 0 1 1 1 0 Sigma 54 modulation protein / S30EA ribosomal protein Cyclin_N PF00134.18 KOO23996.1 - 7.5e-28 96.6 0.1 7.9e-23 80.4 0.0 2.1 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.14 KOO23996.1 - 2.4e-05 24.2 0.4 4.3e-05 23.4 0.3 1.4 1 0 0 1 1 1 1 Cyclin, C-terminal domain Mmp37 PF09139.6 KOO23998.1 - 1.1e-68 231.7 0.0 1.3e-68 231.4 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial matrix Mmp37 FH2 PF02181.18 KOO23999.1 - 3.1e-38 131.6 0.1 3.4e-18 65.6 0.1 3.0 1 1 1 2 2 2 2 Formin Homology 2 Domain DUF607 PF04678.8 KOO23999.1 - 0.092 12.6 0.2 0.46 10.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF607 TBPIP PF07106.8 KOO23999.1 - 0.096 12.2 0.0 0.22 11.0 0.0 1.6 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF4254 PF14063.1 KOO23999.1 - 0.097 12.2 1.5 0.11 12.0 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4254) GrpE PF01025.14 KOO23999.1 - 0.41 10.1 5.1 0.61 9.6 1.6 2.1 1 1 1 2 2 2 0 GrpE PEP-utilisers_N PF05524.8 KOO23999.1 - 1.4 8.7 9.5 0.33 10.7 2.9 2.3 2 1 1 3 3 3 0 PEP-utilising enzyme, N-terminal Peptidase_M18 PF02127.10 KOO24000.1 - 6.2e-90 301.7 0.0 6.1e-89 298.4 0.0 1.9 1 1 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) HALZ PF02183.13 KOO24001.1 - 0.0031 17.1 0.3 0.0075 15.9 0.1 1.8 1 1 0 1 1 1 1 Homeobox associated leucine zipper DUF3924 PF13062.1 KOO24004.1 - 0.0023 17.7 0.0 38 4.2 0.0 4.1 5 0 0 5 5 5 1 Protein of unknown function (DUF3924) TfoX_C PF04994.8 KOO24004.1 - 0.0031 17.3 0.0 21 5.1 0.0 5.0 5 1 1 6 6 6 1 TfoX C-terminal domain DUF2397 PF09660.5 KOO24004.1 - 0.32 9.5 26.3 0.41 9.1 1.5 3.7 1 1 3 4 4 4 0 Protein of unknown function (DUF2397) Arm PF00514.18 KOO24005.1 - 1.9e-85 278.1 66.5 1.2e-09 37.6 0.1 18.5 19 0 0 19 19 19 14 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.4 KOO24005.1 - 1.3e-11 44.1 19.0 0.17 11.6 0.0 8.4 6 3 3 9 9 9 5 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.8 KOO24005.1 - 1e-06 28.0 18.6 0.83 8.7 0.1 7.6 2 2 5 7 7 7 3 Armadillo-like HEAT_EZ PF13513.1 KOO24005.1 - 2.7e-06 27.6 61.7 0.0071 16.7 1.9 11.6 11 4 2 13 13 11 3 HEAT-like repeat HEAT_2 PF13646.1 KOO24005.1 - 3.7e-06 27.1 65.7 0.00035 20.8 5.6 7.8 4 2 6 10 10 9 6 HEAT repeats Adaptin_N PF01602.15 KOO24005.1 - 0.022 13.0 0.1 2 6.6 0.0 3.4 2 2 1 3 3 3 0 Adaptin N terminal region Sigma70_r1_1 PF03979.9 KOO24005.1 - 0.089 12.7 0.1 9.5 6.2 0.0 2.5 2 0 0 2 2 2 0 Sigma-70 factor, region 1.1 HET PF06985.6 KOO24005.1 - 0.11 12.6 0.1 57 3.8 0.0 4.2 4 0 0 4 4 4 0 Heterokaryon incompatibility protein (HET) ACC_central PF08326.7 KOO24005.1 - 0.17 9.9 2.8 9.5 4.1 0.0 4.1 4 1 2 6 6 6 0 Acetyl-CoA carboxylase, central region KAP PF05804.7 KOO24005.1 - 0.3 8.9 0.0 20 2.9 0.0 2.8 3 0 0 3 3 3 0 Kinesin-associated protein (KAP) HEAT PF02985.17 KOO24005.1 - 0.3 11.2 21.2 49 4.3 0.0 10.1 13 0 0 13 13 12 0 HEAT repeat N1221 PF07923.8 KOO24005.1 - 2.9 6.6 3.2 1.6e+02 0.9 0.0 4.3 3 2 4 7 7 7 0 N1221-like protein SET PF00856.23 KOO24006.1 - 7.2e-09 36.1 0.2 1.6e-08 35.0 0.0 1.6 2 0 0 2 2 2 1 SET domain Abhydrolase_3 PF07859.8 KOO24007.1 - 1.7e-07 31.0 0.0 3.5e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold UAA PF08449.6 KOO24007.1 - 2.4e-06 26.6 13.6 1.2e-05 24.3 9.4 1.9 1 1 0 1 1 1 1 UAA transporter family EmrE PF13536.1 KOO24007.1 - 0.0094 16.1 20.3 0.21 11.8 4.3 3.0 2 1 0 2 2 2 2 Multidrug resistance efflux transporter EamA PF00892.15 KOO24007.1 - 0.46 10.5 21.6 0.016 15.2 4.1 2.7 1 1 0 2 2 2 0 EamA-like transporter family Ion_trans PF00520.26 KOO24009.1 - 1.7e-20 73.1 5.0 2.5e-20 72.5 3.4 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO24009.1 - 1.2e-08 34.4 2.0 3.4e-08 33.1 1.4 1.7 1 0 0 1 1 1 1 Ion channel EF-hand_7 PF13499.1 KOO24010.1 - 9.4e-10 38.4 2.4 3.3e-05 23.9 0.1 3.6 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO24010.1 - 7.1e-08 31.2 8.0 0.023 14.0 0.4 3.7 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 KOO24010.1 - 2.5e-07 30.0 8.7 0.027 14.3 0.1 3.7 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.1 KOO24010.1 - 8e-07 28.1 10.4 0.0083 15.4 0.2 3.7 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 KOO24010.1 - 0.0012 18.3 6.3 0.2 11.2 0.5 3.4 3 0 0 3 3 3 2 EF-hand domain pair Pectate_lyase_2 PF06917.7 KOO24010.1 - 0.028 12.7 0.0 0.041 12.1 0.0 1.1 1 0 0 1 1 1 0 Periplasmic pectate lyase Sel1 PF08238.7 KOO24011.1 - 6.2e-13 48.9 16.0 2.4e-06 27.9 0.5 4.0 4 0 0 4 4 4 3 Sel1 repeat 2OG-FeII_Oxy PF03171.15 KOO24011.1 - 0.057 13.7 0.0 0.097 12.9 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily ADPrib_exo_Tox PF03496.9 KOO24012.1 - 2.8e-09 36.4 0.0 9.2e-09 34.7 0.0 1.8 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme ART PF01129.13 KOO24012.1 - 4.8e-08 32.3 0.0 4.8e-08 32.3 0.0 2.1 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase IncA PF04156.9 KOO24012.1 - 0.046 13.3 24.9 0.075 12.6 0.7 2.4 2 0 0 2 2 2 0 IncA protein DUF342 PF03961.8 KOO24012.1 - 6 5.1 12.8 2.8 6.2 6.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF342) Exonuc_VII_L PF02601.10 KOO24012.1 - 7.4 5.6 14.4 22 4.0 10.0 1.8 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4316 PF14195.1 KOO24013.1 - 0.14 12.2 1.0 0.22 11.6 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4316) MCPVI PF02993.9 KOO24013.1 - 0.49 10.5 6.4 0.77 9.8 4.4 1.3 1 0 0 1 1 1 0 Minor capsid protein VI Abhydrolase_6 PF12697.2 KOO24014.1 - 2.6e-17 63.4 1.7 4.3e-17 62.7 1.2 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO24014.1 - 2.3e-15 56.8 0.1 8.9e-15 54.8 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 KOO24014.1 - 4.9e-09 36.0 1.0 4e-08 33.1 0.7 2.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 KOO24014.1 - 6.1e-06 25.5 0.0 0.0013 17.9 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.3 KOO24014.1 - 0.027 14.3 0.3 1.5 8.7 0.0 2.6 2 0 0 2 2 2 0 Putative lysophospholipase DLH PF01738.13 KOO24014.1 - 0.039 13.2 0.1 0.14 11.4 0.1 1.8 2 0 0 2 2 2 0 Dienelactone hydrolase family Neurokinin_B PF03823.9 KOO24014.1 - 0.054 13.2 0.1 0.14 11.9 0.1 1.6 1 0 0 1 1 1 0 Neurokinin B Abhydrolase_2 PF02230.11 KOO24014.1 - 0.12 11.7 0.0 0.65 9.4 0.0 2.0 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase OTU PF02338.14 KOO24017.1 - 1.4e-20 74.0 0.0 2.5e-20 73.2 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 KOO24017.1 - 0.00045 19.6 0.1 0.17 11.1 0.0 2.2 2 0 0 2 2 2 2 Peptidase C65 Otubain ADSL_C PF10397.4 KOO24017.1 - 0.1 12.6 0.6 0.81 9.7 0.1 2.2 2 0 0 2 2 2 0 Adenylosuccinate lyase C-terminus DUF641 PF04859.7 KOO24018.1 - 0.0086 15.8 7.0 0.016 14.9 4.5 1.7 1 1 1 2 2 2 1 Plant protein of unknown function (DUF641) V_ATPase_I PF01496.14 KOO24018.1 - 0.012 13.5 2.7 0.014 13.3 1.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ERM PF00769.14 KOO24018.1 - 0.015 14.8 12.3 0.02 14.4 8.5 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family TMF_TATA_bd PF12325.3 KOO24018.1 - 0.064 12.9 11.9 0.15 11.7 2.4 2.8 1 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding Reo_sigmaC PF04582.7 KOO24018.1 - 0.078 12.1 0.4 0.1 11.7 0.3 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein TMF_DNA_bd PF12329.3 KOO24018.1 - 0.21 11.4 6.7 0.28 11.0 3.3 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding GAS PF13851.1 KOO24018.1 - 0.39 9.8 7.4 0.67 9.1 5.2 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding AAA_13 PF13166.1 KOO24018.1 - 0.42 9.0 2.5 0.5 8.7 1.7 1.1 1 0 0 1 1 1 0 AAA domain MCC-bdg_PDZ PF10506.4 KOO24018.1 - 0.63 9.9 12.9 3.8 7.4 2.1 3.0 1 1 2 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome KLRAQ PF10205.4 KOO24018.1 - 1.2 9.1 11.5 0.94 9.5 3.4 2.4 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein APG6 PF04111.7 KOO24018.1 - 1.3 7.9 6.3 1.8 7.4 4.4 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Pkinase PF00069.20 KOO24019.1 - 2.5e-53 180.8 0.0 6e-36 123.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO24019.1 - 1.3e-29 103.1 0.0 1.8e-25 89.5 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase Kdo PF06293.9 KOO24019.1 - 0.00012 21.1 0.0 0.00018 20.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO24019.1 - 0.0065 16.2 0.1 2.7 7.6 0.0 3.1 3 0 0 3 3 3 1 Phosphotransferase enzyme family CRAL_TRIO PF00650.15 KOO24020.1 - 1.8e-27 95.7 0.0 2.4e-27 95.3 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 KOO24020.1 - 0.027 14.6 0.1 0.071 13.2 0.1 1.7 2 0 0 2 2 2 0 CRAL/TRIO, N-terminal domain SOUL PF04832.7 KOO24021.1 - 4.4e-45 153.3 0.5 7.5e-45 152.6 0.3 1.3 1 1 0 1 1 1 1 SOUL heme-binding protein IFRD_C PF04836.7 KOO24022.1 - 0.067 13.3 4.5 0.14 12.3 3.1 1.5 1 0 0 1 1 1 0 Interferon-related protein conserved region Sugar_transport PF06800.7 KOO24022.1 - 0.1 11.6 0.0 0.13 11.3 0.0 1.1 1 0 0 1 1 1 0 Sugar transport protein NADH-u_ox-rdase PF10785.4 KOO24023.1 - 9.4e-09 35.4 0.1 2.1e-08 34.2 0.1 1.6 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit Cupin_8 PF13621.1 KOO24024.1 - 3.3e-34 118.5 0.0 3.7e-34 118.3 0.0 1.0 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 KOO24024.1 - 8.2e-09 35.1 0.2 5.1e-08 32.5 0.1 1.9 1 1 0 1 1 1 1 Cupin superfamily protein Cupin_2 PF07883.6 KOO24024.1 - 0.00018 20.9 0.1 0.00073 18.9 0.0 2.0 2 0 0 2 2 2 1 Cupin domain JmjC PF02373.17 KOO24024.1 - 0.0003 21.0 0.1 0.0053 16.9 0.0 2.1 2 0 0 2 2 2 1 JmjC domain, hydroxylase Pkinase PF00069.20 KOO24025.1 - 3.8e-59 199.9 0.0 4.3e-59 199.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO24025.1 - 3.4e-36 124.6 0.0 4.1e-36 124.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO24025.1 - 4.4e-08 32.4 0.0 7e-07 28.4 0.0 2.0 1 1 0 2 2 2 1 Kinase-like APH PF01636.18 KOO24025.1 - 0.00043 20.1 1.0 0.016 14.9 0.3 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 KOO24025.1 - 0.089 11.8 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_S51 PF03575.12 KOO24027.1 - 5e-06 26.3 0.0 0.00012 21.7 0.0 2.6 1 1 0 1 1 1 1 Peptidase family S51 Mito_carr PF00153.22 KOO24028.1 - 3.2e-40 135.7 3.1 4.4e-19 67.9 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Use1 PF09753.4 KOO24029.1 - 1.2e-29 103.5 5.6 1.3e-29 103.3 3.9 1.0 1 0 0 1 1 1 1 Membrane fusion protein Use1 Nup54 PF13874.1 KOO24029.1 - 0.035 13.7 0.5 0.035 13.7 0.3 2.7 2 1 0 3 3 3 0 Nucleoporin complex subunit 54 ATG16 PF08614.6 KOO24029.1 - 0.045 13.5 14.0 0.36 10.6 6.6 2.4 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) TMEM156 PF15106.1 KOO24029.1 - 0.1 11.8 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 TMEM156 protein family DUF2580 PF10824.3 KOO24029.1 - 1.4 9.3 10.1 16 5.8 4.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2580) T2SF PF00482.18 KOO24029.1 - 4.3 7.2 7.6 4.3 7.2 0.2 3.1 2 1 0 2 2 2 0 Type II secretion system (T2SS), protein F Pro_isomerase PF00160.16 KOO24030.1 - 9.2e-13 48.6 0.0 1.2e-12 48.2 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD HR1 PF02185.11 KOO24031.1 - 0.0085 15.8 0.4 0.0085 15.8 0.3 3.1 3 0 0 3 3 3 1 Hr1 repeat DUF4404 PF14357.1 KOO24031.1 - 0.027 14.8 1.4 0.027 14.8 1.0 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF4404) SNF2_N PF00176.18 KOO24033.1 - 6e-20 71.2 0.0 1e-17 63.9 0.0 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain ResIII PF04851.10 KOO24033.1 - 0.013 15.3 0.0 0.098 12.4 0.0 2.1 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Telomere_Sde2_2 PF13297.1 KOO24033.1 - 0.013 14.7 0.1 0.041 13.1 0.1 1.8 1 0 0 1 1 1 0 Telomere stability C-terminal DNA_methylase PF00145.12 KOO24033.1 - 0.038 13.1 0.0 1.2 8.1 0.0 2.5 2 0 0 2 2 2 0 C-5 cytosine-specific DNA methylase DUF3638 PF12340.3 KOO24034.1 - 6.5e-43 146.3 0.4 1.3e-42 145.3 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.3 KOO24034.1 - 2.8e-11 42.3 0.1 7.3e-11 41.0 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) ubiquitin PF00240.18 KOO24034.1 - 0.041 13.2 0.0 0.11 11.9 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin family Glyco_hydro_32N PF00251.15 KOO24034.1 - 0.59 9.4 2.9 4.1 6.6 0.2 2.4 2 0 0 2 2 2 0 Glycosyl hydrolases family 32 N-terminal domain HEAT_EZ PF13513.1 KOO24035.1 - 4.7 7.8 9.4 18 5.9 1.9 4.4 3 2 1 4 4 4 0 HEAT-like repeat zf-C2H2_jaz PF12171.3 KOO24036.1 - 9.1e-07 28.8 5.8 2.2e-06 27.6 4.0 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 KOO24036.1 - 0.00024 21.1 4.6 0.00053 20.0 3.2 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type KIAA1430 PF13879.1 KOO24036.1 - 0.013 15.9 0.0 0.013 15.9 0.0 2.2 3 0 0 3 3 3 0 KIAA1430 homologue zf-C2H2_2 PF12756.2 KOO24036.1 - 0.12 12.5 0.7 0.25 11.4 0.5 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) eIF2A PF08662.6 KOO24037.1 - 1.6e-51 174.7 7.7 4e-50 170.2 0.9 3.4 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A WASH-7_C PF14746.1 KOO24037.1 - 0.042 13.4 1.4 0.086 12.4 1.0 1.4 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal DUF2580 PF10824.3 KOO24037.1 - 0.16 12.3 0.6 3.9 7.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2580) WD40 PF00400.27 KOO24037.1 - 1.1 9.2 8.0 31 4.6 0.0 5.0 6 0 0 6 6 6 0 WD domain, G-beta repeat DUF4349 PF14257.1 KOO24038.1 - 0.021 14.0 3.1 0.025 13.7 2.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) DUF641 PF04859.7 KOO24038.1 - 0.05 13.3 3.1 0.072 12.8 2.1 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) FYDLN_acid PF09538.5 KOO24038.1 - 0.071 13.6 0.8 0.097 13.2 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Bap31 PF05529.7 KOO24038.1 - 0.2 11.0 1.7 0.28 10.5 1.2 1.2 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like Atg14 PF10186.4 KOO24038.1 - 2 7.3 3.9 2.4 7.0 2.7 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 OmpH PF03938.9 KOO24038.1 - 3.1 7.7 8.0 4.2 7.2 5.5 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DnaJ PF00226.26 KOO24039.1 - 0.00041 20.0 0.1 0.00073 19.2 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain PC-Esterase PF13839.1 KOO24040.1 - 0.0029 17.4 0.0 0.0042 16.9 0.0 1.7 1 1 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p ATG22 PF11700.3 KOO24041.1 - 1.8e-77 260.8 21.8 2.1e-77 260.6 15.1 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.11 KOO24041.1 - 1e-09 37.5 48.1 1.5e-06 27.1 19.5 2.9 2 1 1 3 3 3 3 Major Facilitator Superfamily DUF393 PF04134.7 KOO24041.1 - 0.14 13.2 0.4 0.66 11.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF393 GMP_PDE_delta PF05351.6 KOO24042.1 - 7.2e-49 165.6 0.1 8.1e-49 165.4 0.1 1.0 1 0 0 1 1 1 1 GMP-PDE, delta subunit IF-2B PF01008.12 KOO24043.1 - 1.1e-65 221.4 0.0 2.1e-65 220.5 0.0 1.4 1 1 0 1 1 1 1 Initiation factor 2 subunit family Ank_2 PF12796.2 KOO24044.1 - 4.7e-29 100.5 1.7 1.7e-15 57.1 1.4 2.7 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO24044.1 - 6.7e-27 91.9 13.7 1.2e-06 28.0 0.0 5.7 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.1 KOO24044.1 - 4.9e-22 77.4 9.0 9.7e-09 35.1 0.0 5.3 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO24044.1 - 2.2e-20 70.6 1.4 0.0051 16.9 0.0 5.6 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.1 KOO24044.1 - 2.3e-18 66.1 4.1 1.5e-06 28.5 0.0 3.9 2 2 2 4 4 4 4 Ankyrin repeats (many copies) DUF2360 PF10152.4 KOO24044.1 - 0.77 10.0 7.9 8.5 6.6 0.3 2.6 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) Mito_fiss_reg PF05308.6 KOO24044.1 - 2.1 7.6 13.2 3.6 6.8 3.6 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator CAP_N PF01213.14 KOO24044.1 - 2.2 7.5 22.1 0.029 13.6 2.9 2.2 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal EF-hand_1 PF00036.27 KOO24046.1 - 2.5e-09 35.7 0.1 0.0011 18.1 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO24046.1 - 2e-08 33.4 0.0 0.0047 16.6 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO24046.1 - 1.9e-07 31.0 1.7 6.8e-07 29.3 0.0 2.9 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO24046.1 - 4.4e-06 26.2 0.0 1.5e-05 24.4 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO24046.1 - 0.002 17.3 0.2 0.014 14.7 0.0 2.6 2 0 0 2 2 2 1 EF hand Strep_SA_rep PF06696.6 KOO24046.1 - 6.5 6.6 19.9 3.5 7.5 0.5 5.6 5 1 1 6 6 6 0 Streptococcal surface antigen repeat Apc3 PF12895.2 KOO24047.1 - 1.1e-16 60.7 16.8 0.00014 21.9 0.0 5.6 3 1 1 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 KOO24047.1 - 2.5e-14 53.3 18.1 0.00028 21.1 0.9 7.0 5 1 3 8 8 7 4 Tetratricopeptide repeat TPR_11 PF13414.1 KOO24047.1 - 1.9e-12 46.6 23.9 3e-07 29.9 0.2 6.1 4 2 1 6 6 6 3 TPR repeat TPR_16 PF13432.1 KOO24047.1 - 1.5e-11 44.6 25.1 0.0024 18.5 0.2 6.6 4 1 1 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.1 KOO24047.1 - 9.2e-10 38.2 17.5 0.55 11.0 0.1 8.7 5 4 3 8 8 8 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO24047.1 - 3.9e-07 29.4 28.5 0.0099 15.7 0.6 8.7 10 0 0 10 10 8 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO24047.1 - 1.3e-06 28.0 7.0 0.028 14.5 0.1 6.7 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOO24047.1 - 1.6e-06 27.9 18.1 1.7 8.6 0.0 7.4 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOO24047.1 - 6.8e-06 25.8 7.4 0.0014 18.3 1.0 4.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO24047.1 - 0.00036 20.1 4.3 0.25 11.2 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.1 KOO24047.1 - 0.00064 18.8 11.9 0.0014 17.7 0.2 4.1 4 1 0 4 4 4 2 Tetratricopeptide repeat Coatomer_E PF04733.9 KOO24047.1 - 0.0013 17.9 1.7 0.011 14.9 0.2 2.9 2 2 1 3 3 3 1 Coatomer epsilon subunit TPR_10 PF13374.1 KOO24047.1 - 0.0014 18.5 9.3 4.9 7.2 0.0 5.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_4 PF07721.9 KOO24047.1 - 0.0032 17.7 2.5 0.77 10.3 0.4 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat PPR PF01535.15 KOO24047.1 - 0.0056 16.5 1.1 2.4 8.3 0.2 4.2 4 0 0 4 4 3 1 PPR repeat TPR_6 PF13174.1 KOO24047.1 - 0.0097 16.3 23.2 0.12 12.8 0.2 6.8 7 1 1 8 8 6 2 Tetratricopeptide repeat PPR_2 PF13041.1 KOO24047.1 - 0.017 15.0 1.0 4.5 7.3 0.0 3.4 3 0 0 3 3 3 0 PPR repeat family Fis1_TPR_C PF14853.1 KOO24047.1 - 0.022 14.6 1.4 0.022 14.6 1.0 5.2 6 0 0 6 6 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.23 KOO24047.1 - 0.039 13.5 17.0 0.07 12.7 0.5 6.1 7 0 0 7 7 6 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.5 KOO24047.1 - 0.051 13.0 0.3 3.2 7.2 0.1 3.0 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) DUF3768 PF12599.3 KOO24047.1 - 0.079 12.8 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3768) TPR_8 PF13181.1 KOO24047.1 - 6.2 6.8 8.9 3.9 7.4 0.1 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat ARL2_Bind_BART PF11527.3 KOO24048.1 - 5.1e-20 71.4 0.4 6.6e-20 71.1 0.2 1.1 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART Erythro_esteras PF05139.9 KOO24049.1 - 1.5e-85 287.4 3.0 1.1e-57 195.8 0.0 3.1 3 0 0 3 3 3 3 Erythromycin esterase HCaRG PF07258.9 KOO24050.1 - 2.5e-14 53.1 0.0 3e-14 52.9 0.0 1.1 1 0 0 1 1 1 1 HCaRG protein ACP_syn_III_C PF08541.5 KOO24051.1 - 3.3e-39 132.8 0.3 7.7e-39 131.6 0.1 1.8 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.5 KOO24051.1 - 2e-30 104.2 0.4 2e-30 104.2 0.3 3.1 4 0 0 4 4 4 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III FAE1_CUT1_RppA PF08392.7 KOO24051.1 - 0.00023 20.3 0.0 0.0052 15.8 0.0 2.1 2 0 0 2 2 2 1 FAE1/Type III polyketide synthase-like protein Chal_sti_synt_C PF02797.10 KOO24051.1 - 0.00054 19.9 0.0 0.00092 19.1 0.0 1.3 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain Thiolase_C PF02803.13 KOO24051.1 - 0.0024 17.2 0.7 0.0088 15.4 0.1 2.2 2 1 0 2 2 2 1 Thiolase, C-terminal domain Thiolase_N PF00108.18 KOO24051.1 - 0.0043 16.0 0.1 0.028 13.4 0.0 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain ketoacyl-synt PF00109.21 KOO24051.1 - 0.0051 16.3 3.5 2.2 7.6 0.1 3.8 2 1 3 5 5 5 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 KOO24051.1 - 0.019 14.8 0.0 8.5 6.2 0.0 2.7 2 0 0 2 2 2 0 Beta-ketoacyl synthase, C-terminal domain Chal_sti_synt_N PF00195.14 KOO24051.1 - 0.072 12.3 1.0 2.2 7.4 0.3 2.8 1 1 1 2 2 2 0 Chalcone and stilbene synthases, N-terminal domain Ribonuc_L-PSP PF01042.16 KOO24053.1 - 5.8e-20 71.2 0.0 7.5e-20 70.8 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP AMP-binding PF00501.23 KOO24054.1 - 9.3e-39 132.9 0.4 2e-38 131.8 0.3 1.5 1 0 0 1 1 1 1 AMP-binding enzyme Glyco_transf_90 PF05686.7 KOO24054.1 - 2.8e-22 78.9 0.0 8.2e-15 54.3 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 90 PAN_1 PF00024.21 KOO24054.1 - 0.012 15.3 0.3 0.029 14.1 0.2 1.6 1 0 0 1 1 1 0 PAN domain His_Phos_1 PF00300.17 KOO24055.1 - 4.4e-71 238.0 0.0 4.1e-34 117.9 0.0 2.8 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) Kelch_4 PF13418.1 KOO24059.1 - 1.1e-32 111.5 14.3 6.1e-09 35.5 0.0 6.5 6 1 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.1 KOO24059.1 - 3e-32 110.0 16.3 1e-07 31.8 0.0 7.0 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_1 PF01344.20 KOO24059.1 - 1e-29 101.7 2.7 7.7e-07 28.5 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.1 KOO24059.1 - 9.4e-29 98.8 5.5 1.3e-05 24.9 0.0 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.10 KOO24059.1 - 9.5e-28 94.8 8.7 1.8e-06 27.5 0.1 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.1 KOO24059.1 - 3.9e-24 83.7 4.6 4.7e-06 26.5 0.0 6.1 6 0 0 6 6 6 5 Kelch motif PQQ_3 PF13570.1 KOO24059.1 - 0.46 10.8 8.8 14 6.1 0.0 4.5 5 0 0 5 5 5 0 PQQ-like domain CENP-F_leu_zip PF10473.4 KOO24060.1 - 5.5e-05 23.0 36.3 0.0011 18.8 1.4 5.1 3 1 0 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6 PF04111.7 KOO24060.1 - 0.00094 18.3 33.6 0.0055 15.7 2.0 3.9 1 1 3 4 4 4 3 Autophagy protein Apg6 Gln-synt_C PF00120.19 KOO24060.1 - 0.037 13.1 3.2 0.071 12.2 2.2 1.4 1 0 0 1 1 1 0 Glutamine synthetase, catalytic domain GAS PF13851.1 KOO24060.1 - 0.24 10.5 31.9 0.083 12.0 4.2 4.8 2 1 3 5 5 5 0 Growth-arrest specific micro-tubule binding YvrJ PF12841.2 KOO24060.1 - 0.55 9.5 1.7 15 5.0 0.1 2.5 2 0 0 2 2 2 0 YvrJ protein family TMF_DNA_bd PF12329.3 KOO24060.1 - 2 8.2 27.1 1.5 8.6 0.1 6.3 5 1 0 5 5 5 0 TATA element modulatory factor 1 DNA binding HOOK PF05622.7 KOO24060.1 - 5 4.8 34.1 2.7 5.6 18.0 2.7 1 1 0 2 2 2 0 HOOK protein IncA PF04156.9 KOO24060.1 - 6.5 6.3 44.1 1.7 8.2 3.4 4.2 1 1 2 3 3 3 0 IncA protein DUF972 PF06156.8 KOO24060.1 - 8 6.8 28.0 1 9.7 1.4 6.0 1 1 4 6 6 6 0 Protein of unknown function (DUF972) Ufd2P_core PF10408.4 KOO24061.1 - 5.8e-44 150.3 0.0 1.5e-26 92.8 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin elongating factor core UQ_con PF00179.21 KOO24061.1 - 1.5e-17 63.3 0.0 2.8e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.8 KOO24061.1 - 3.8e-05 23.3 0.0 7e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 UEV domain RWD PF05773.17 KOO24061.1 - 0.13 12.1 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 RWD domain WW PF00397.21 KOO24062.1 - 7.3e-06 25.7 1.2 1.3e-05 24.9 0.8 1.4 1 0 0 1 1 1 1 WW domain Pox_Ag35 PF03286.9 KOO24062.1 - 0.0046 16.5 2.5 0.0071 15.8 1.7 1.3 1 0 0 1 1 1 1 Pox virus Ag35 surface protein FYDLN_acid PF09538.5 KOO24062.1 - 0.16 12.5 5.8 0.3 11.7 4.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Peptidase_M10 PF00413.19 KOO24064.1 - 6.1e-07 29.2 0.0 0.0016 18.2 0.0 3.2 3 0 0 3 3 3 2 Matrixin Reprolysin_5 PF13688.1 KOO24064.1 - 0.0077 16.1 0.3 0.083 12.8 0.1 2.3 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.1 KOO24064.1 - 0.011 15.7 0.1 0.026 14.5 0.1 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.1 KOO24064.1 - 0.061 12.8 0.0 0.16 11.4 0.0 1.7 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.3 KOO24064.1 - 0.063 12.5 0.1 3.2 7.0 0.0 2.7 3 0 0 3 3 3 0 Dual-action HEIGH metallo-peptidase Reprolysin_3 PF13582.1 KOO24064.1 - 0.14 12.7 0.8 0.36 11.3 0.1 2.0 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Mito_carr PF00153.22 KOO24066.1 - 3.9e-39 132.2 0.1 6.5e-15 54.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein dCMP_cyt_deam_2 PF08211.6 KOO24067.1 - 0.018 15.0 0.3 0.037 14.0 0.2 1.5 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region DUF162 PF02589.10 KOO24067.1 - 0.078 12.4 0.6 0.12 11.8 0.4 1.3 1 0 0 1 1 1 0 Uncharacterised ACR, YkgG family COG1556 GCN5L1 PF06320.8 KOO24067.1 - 0.13 12.1 0.6 0.21 11.4 0.4 1.3 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) NTP_transferase PF00483.18 KOO24068.1 - 9.2e-26 90.6 0.0 1.2e-25 90.2 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.19 KOO24068.1 - 5.2e-10 38.3 0.7 5.8e-08 31.8 0.3 2.9 1 1 0 2 2 2 1 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.2 KOO24068.1 - 6.8e-05 23.0 0.0 0.00011 22.3 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.1 KOO24068.1 - 0.009 15.5 2.3 0.009 15.5 1.6 3.2 2 1 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.7 KOO24068.1 - 0.048 12.2 0.4 1.3 7.5 0.0 2.3 2 1 1 3 3 3 0 L-fucokinase Ion_trans PF00520.26 KOO24069.1 - 1.5e-155 514.0 57.5 2.2e-42 144.5 5.4 4.4 4 0 0 4 4 4 4 Ion transport protein Ank_2 PF12796.2 KOO24069.1 - 5.2e-31 106.8 3.9 1.9e-11 44.1 0.2 3.8 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO24069.1 - 3.4e-25 86.5 15.1 5.1e-05 22.8 0.0 7.6 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.1 KOO24069.1 - 1.3e-18 66.5 10.8 0.00019 21.5 0.1 5.6 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO24069.1 - 2.6e-16 59.6 2.9 8e-07 29.4 0.1 4.7 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO24069.1 - 1.1e-15 56.1 4.7 0.0091 16.1 0.1 6.1 5 0 0 5 5 5 4 Ankyrin repeat U-box PF04564.10 KOO24069.1 - 5.6e-14 51.8 0.0 1.2e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 U-box domain K_oxygenase PF13434.1 KOO24069.1 - 0.002 17.1 0.0 0.048 12.5 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.22 KOO24069.1 - 0.0069 16.7 0.0 0.016 15.5 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase zf-Nse PF11789.3 KOO24069.1 - 0.13 11.7 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Herpes_IR6 PF06307.7 KOO24069.1 - 0.66 9.2 0.0 1.2 8.4 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus IR6 protein CMV_1a PF12467.3 KOO24069.1 - 0.79 10.0 5.1 1.6 9.0 3.6 1.4 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family Pentapeptide_4 PF13599.1 KOO24070.1 - 1e-67 223.9 0.0 3.3e-09 36.4 0.0 11.9 1 1 9 12 12 12 12 Pentapeptide repeats (9 copies) Ribosomal_L13e PF01294.13 KOO24070.1 - 1.6e-06 27.7 35.0 0.093 12.1 0.1 13.7 7 3 11 18 18 18 3 Ribosomal protein L13e Toxin_54 PF15533.1 KOO24070.1 - 0.00018 21.6 8.4 16 5.7 0.0 10.2 7 3 3 10 10 10 0 Putative toxin 54 MerR_1 PF13411.1 KOO24070.1 - 0.0045 16.7 0.1 33 4.3 0.0 6.8 7 1 2 9 9 9 0 MerR HTH family regulatory protein SAP PF02037.22 KOO24070.1 - 0.0099 15.3 0.5 15 5.2 0.0 7.1 6 0 0 6 6 6 0 SAP domain DUF724 PF05266.9 KOO24070.1 - 0.27 10.8 0.3 90 2.6 0.0 4.8 4 1 1 5 5 5 0 Protein of unknown function (DUF724) DUF4110 PF13422.1 KOO24070.1 - 0.32 10.8 1.5 53 3.7 0.0 4.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4110) Bradykinin PF06753.7 KOO24070.1 - 1.3 8.5 5.3 11 5.6 0.1 4.4 3 0 0 3 3 3 0 Bradykinin Ifi-6-16 PF06140.8 KOO24070.1 - 3.8 7.3 17.4 14 5.5 0.0 6.5 5 2 1 6 6 6 0 Interferon-induced 6-16 family TrbH PF07283.6 KOO24070.1 - 6.9 6.5 10.3 69 3.3 0.0 6.9 8 2 2 10 10 10 0 Conjugal transfer protein TrbH DUF1538 PF07556.6 KOO24073.1 - 1.1e-85 286.0 28.3 1.8e-46 157.9 10.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1538) DUF1279 PF06916.8 KOO24074.1 - 3.7e-09 36.7 0.0 5.9e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) MAPEG PF01124.13 KOO24075.1 - 1.1e-14 54.2 0.3 1.4e-14 53.8 0.2 1.2 1 0 0 1 1 1 1 MAPEG family Lipase_GDSL_2 PF13472.1 KOO24076.1 - 1e-18 68.1 0.2 2.2e-18 67.0 0.1 1.6 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 KOO24076.1 - 4e-07 30.1 0.1 7.5e-06 25.9 0.1 2.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.1 KOO24076.1 - 0.054 13.2 0.0 1 9.0 0.0 2.2 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase family HATPase_c PF02518.21 KOO24077.1 - 1.8e-10 40.5 0.0 4.1e-10 39.3 0.0 1.6 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 KOO24077.1 - 0.036 13.7 0.0 0.056 13.1 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.1 KOO24077.1 - 0.047 13.4 0.0 0.073 12.8 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Ank_2 PF12796.2 KOO24078.1 - 4.1e-12 46.2 0.0 4.9e-12 46.0 0.0 1.0 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO24078.1 - 1.4e-11 44.1 0.1 5.9e-08 32.7 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO24078.1 - 6.3e-10 39.2 0.0 1.9e-06 28.2 0.0 2.1 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO24078.1 - 4.5e-09 35.6 0.0 0.0032 17.2 0.0 3.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.1 KOO24078.1 - 2.9e-08 33.1 0.0 0.0002 21.3 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat WD40 PF00400.27 KOO24079.1 - 1e-45 152.0 28.4 3.5e-07 29.8 0.1 8.4 7 3 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 KOO24079.1 - 4.8e-20 71.2 23.4 0.013 13.6 0.1 7.0 2 1 5 7 7 7 7 Nucleoporin Nup120/160 Kelch_6 PF13964.1 KOO24079.1 - 5.2e-14 51.7 2.7 1.4 9.1 0.0 7.0 7 0 0 7 7 7 5 Kelch motif Kelch_2 PF07646.10 KOO24079.1 - 2.5e-10 39.6 5.3 3.7 7.4 0.1 7.1 7 0 0 7 7 7 3 Kelch motif SANTA PF09133.5 KOO24079.1 - 3.7e-05 23.5 0.5 29 4.7 0.0 5.5 4 2 1 6 6 6 0 SANTA (SANT Associated) BON PF04972.12 KOO24079.1 - 0.00026 20.6 9.8 2.9 7.7 0.0 5.0 5 0 0 5 5 5 3 BON domain Dishevelled PF02377.10 KOO24079.1 - 0.0003 20.9 0.2 0.21 11.7 0.0 2.9 3 0 0 3 3 3 1 Dishevelled specific domain FmdE PF02663.9 KOO24079.1 - 0.0017 18.2 12.6 3 7.7 0.0 5.4 1 1 4 6 6 6 2 FmdE, Molybdenum formylmethanofuran dehydrogenase operon KduI PF04962.7 KOO24079.1 - 0.02 13.9 1.0 3.1 6.8 0.1 2.4 1 1 1 2 2 2 0 KduI/IolB family ATP-grasp_4 PF13535.1 KOO24079.1 - 0.04 13.6 4.0 19 4.9 0.0 4.9 1 1 5 6 6 6 0 ATP-grasp domain DUF3049 PF11250.3 KOO24079.1 - 0.11 12.2 4.9 81 3.1 0.0 5.3 7 0 0 7 7 7 0 Protein of unknown function (DUF3049) DUF2180 PF09947.4 KOO24079.1 - 0.15 11.8 9.3 21 4.9 0.0 5.6 2 1 4 6 6 6 0 Uncharacterized protein conserved in archaea (DUF2180) DUF2148 PF09918.4 KOO24079.1 - 0.15 11.7 10.2 9.8 5.9 0.1 4.5 4 0 0 4 4 4 0 Uncharacterized protein containing a ferredoxin domain (DUF2148) Syntaxin-6_N PF09177.6 KOO24080.1 - 0.25 11.7 2.2 0.47 10.8 1.6 1.4 1 0 0 1 1 1 0 Syntaxin 6, N-terminal YfcL PF08891.6 KOO24080.1 - 0.33 10.9 1.7 1.5 8.8 0.0 2.3 2 0 0 2 2 2 0 YfcL protein Allexi_40kDa PF05549.6 KOO24081.1 - 3.7 6.7 9.5 0.34 10.1 1.9 2.1 1 1 1 2 2 2 0 Allexivirus 40kDa protein DSPc PF00782.15 KOO24084.1 - 0.00032 20.2 0.0 0.00044 19.8 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 KOO24084.1 - 0.0052 17.0 0.0 0.0066 16.7 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 KOO24084.1 - 0.094 12.0 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase WD40 PF00400.27 KOO24085.1 - 2.3e-13 49.4 3.7 0.035 14.0 0.0 5.6 6 0 0 6 6 6 4 WD domain, G-beta repeat PUB PF09409.5 KOO24085.1 - 5.3e-10 38.9 0.0 7.8e-10 38.3 0.0 1.3 1 0 0 1 1 1 1 PUB domain UBA PF00627.26 KOO24085.1 - 8.9e-06 25.3 0.1 2.2e-05 24.1 0.1 1.7 1 0 0 1 1 1 1 UBA/TS-N domain PFU PF09070.6 KOO24085.1 - 0.0014 18.5 0.0 0.0022 17.9 0.0 1.2 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) Myb_DNA-binding PF00249.26 KOO24086.1 - 4.9e-07 29.7 0.0 1.2e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_CC_LHEQLE PF14379.1 KOO24086.1 - 1e-06 28.2 11.2 2.2e-06 27.1 7.7 1.6 1 0 0 1 1 1 1 MYB-CC type transfactor, LHEQLE motif Asp_Arg_Hydrox PF05118.10 KOO24087.1 - 5.8e-38 130.2 0.0 1e-37 129.5 0.0 1.4 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase TPR_16 PF13432.1 KOO24087.1 - 9.1e-06 26.2 19.7 0.001 19.6 5.1 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO24087.1 - 2.3e-05 23.9 8.9 0.00012 21.5 1.7 2.4 1 1 2 3 3 3 2 TPR repeat HrpB1_HrpK PF09613.5 KOO24087.1 - 0.047 13.1 0.6 0.11 12.0 0.1 1.8 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) Coatomer_E PF04733.9 KOO24087.1 - 0.075 12.2 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Coatomer epsilon subunit TPR_2 PF07719.12 KOO24087.1 - 0.097 12.6 0.6 0.097 12.6 0.4 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOO24087.1 - 0.11 12.1 2.6 0.66 9.6 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO24087.1 - 0.25 11.2 1.9 1.3 8.9 0.3 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 KOO24087.1 - 0.59 10.5 14.8 2.1 8.7 4.5 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO24087.1 - 0.83 10.2 8.5 15 6.2 1.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO24087.1 - 3 7.8 12.0 0.2 11.6 2.6 2.5 2 1 1 3 3 3 0 Tetratricopeptide repeat Adaptin_N PF01602.15 KOO24088.1 - 1.4e-121 406.3 11.4 3.7e-120 401.7 7.6 1.8 1 1 1 2 2 2 2 Adaptin N terminal region Alpha_adaptinC2 PF02883.15 KOO24088.1 - 1.2e-24 86.8 0.4 2.3e-24 85.9 0.3 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.2 KOO24088.1 - 6e-05 22.9 2.3 6e-05 22.9 1.6 2.3 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 KOO24088.1 - 0.00061 20.0 1.3 0.062 13.5 0.2 4.1 3 1 0 3 3 3 1 HEAT repeats Vac14_Fab1_bd PF12755.2 KOO24088.1 - 0.0044 17.3 1.5 0.22 11.9 0.1 2.9 1 1 1 2 2 2 1 Vacuolar 14 Fab1-binding region HEAT PF02985.17 KOO24088.1 - 0.02 14.9 0.4 1.5 9.1 0.0 3.9 4 0 0 4 4 4 0 HEAT repeat TIP120 PF08623.5 KOO24088.1 - 0.045 13.3 2.7 0.67 9.5 0.1 2.7 1 1 1 2 2 2 0 TATA-binding protein interacting (TIP20) HEAT_EZ PF13513.1 KOO24088.1 - 0.12 12.9 1.3 5.5 7.6 0.1 3.7 3 1 0 3 3 3 0 HEAT-like repeat Syntaxin-6_N PF09177.6 KOO24089.1 - 4e-23 81.6 0.4 5.6e-23 81.1 0.3 1.2 1 0 0 1 1 1 1 Syntaxin 6, N-terminal Peptidase_S8 PF00082.17 KOO24090.1 - 0.003 16.7 0.7 0.0052 15.9 0.5 1.4 1 0 0 1 1 1 1 Subtilase family Tad_C PF09977.4 KOO24090.1 - 0.036 15.0 0.8 0.1 13.6 0.2 2.0 2 0 0 2 2 2 0 Putative Tad-like Flp pilus-assembly TAF8_C PF10406.4 KOO24091.1 - 2.2e-10 40.3 0.4 2.2e-10 40.3 0.3 1.8 2 0 0 2 2 2 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.8 KOO24091.1 - 6.8e-09 35.3 0.0 1.2e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TPT PF03151.11 KOO24092.1 - 1.2e-27 96.4 17.7 1.5e-27 96.1 3.6 2.4 2 1 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.15 KOO24092.1 - 2.4e-13 50.2 23.2 5.2e-07 29.7 3.1 2.4 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.6 KOO24092.1 - 2.5e-05 23.3 12.3 0.00037 19.5 8.5 2.2 1 1 0 1 1 1 1 UAA transporter family DUF2561 PF10812.3 KOO24092.1 - 0.0048 16.5 1.5 0.0069 16.0 0.5 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2561) Nuc_sug_transp PF04142.10 KOO24092.1 - 0.036 13.1 4.1 0.16 11.0 0.8 2.2 2 0 0 2 2 2 0 Nucleotide-sugar transporter EmrE PF13536.1 KOO24092.1 - 0.072 13.2 26.4 0.038 14.1 3.8 3.3 1 1 1 3 3 3 0 Multidrug resistance efflux transporter Pkinase PF00069.20 KOO24093.1 - 3.8e-49 167.1 0.0 4.4e-49 166.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO24093.1 - 1.1e-27 96.7 0.0 1.4e-27 96.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO24093.1 - 4.8e-07 29.0 0.0 8.6e-07 28.1 0.0 1.5 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 KOO24093.1 - 0.005 16.5 0.1 0.014 15.1 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 KOO24093.1 - 0.013 14.5 0.0 0.02 13.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PPR_2 PF13041.1 KOO24094.1 - 1.3e-71 236.3 14.5 2.7e-11 43.2 0.0 9.3 1 1 9 10 10 10 9 PPR repeat family PPR PF01535.15 KOO24094.1 - 1.9e-49 162.2 5.9 1.7e-06 27.5 0.0 9.4 9 0 0 9 9 9 9 PPR repeat PPR_3 PF13812.1 KOO24094.1 - 1.4e-48 159.0 19.1 4.7e-06 26.4 0.0 10.0 10 1 0 10 10 10 9 Pentatricopeptide repeat domain PPR_1 PF12854.2 KOO24094.1 - 9e-26 89.0 14.8 3.2e-05 23.2 0.0 10.5 10 2 0 10 10 10 6 PPR repeat ECSIT PF06239.6 KOO24094.1 - 0.00016 20.6 0.0 0.5 9.1 0.0 3.3 2 1 1 3 3 3 2 Evolutionarily conserved signalling intermediate in Toll pathway TPR_14 PF13428.1 KOO24094.1 - 0.00093 19.6 10.0 21 6.1 0.0 6.4 6 1 0 7 7 7 0 Tetratricopeptide repeat Flu_B_NS1 PF02942.9 KOO24094.1 - 0.0025 16.7 0.1 5.4 5.8 0.0 3.2 2 1 1 3 3 3 2 Influenza B non-structural protein (NS1) TPR_15 PF13429.1 KOO24094.1 - 0.0037 16.3 0.9 0.42 9.6 0.1 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO24094.1 - 0.57 10.5 7.8 2.6 8.4 0.4 4.2 4 1 0 5 5 5 0 Tetratricopeptide repeat S1 PF00575.18 KOO24095.1 - 2.3e-40 136.5 0.0 6.4e-11 42.1 0.1 6.8 6 0 0 6 6 6 5 S1 RNA binding domain Suf PF05843.9 KOO24095.1 - 5.6e-09 36.1 0.2 2.8e-05 23.9 0.0 3.1 1 1 2 3 3 3 2 Suppressor of forked protein (Suf) TPR_19 PF14559.1 KOO24095.1 - 0.00079 19.7 0.0 0.31 11.4 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO24095.1 - 0.0077 16.8 13.3 0.88 10.3 0.0 5.3 3 2 3 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO24095.1 - 0.13 12.9 12.1 7.3 7.5 0.0 6.0 3 2 3 6 6 6 0 Tetratricopeptide repeat NRDE-2 PF08424.5 KOO24095.1 - 0.15 10.9 0.1 2.1 7.1 0.0 2.1 2 0 0 2 2 2 0 NRDE-2, necessary for RNA interference TPR_6 PF13174.1 KOO24095.1 - 0.7 10.4 3.5 1.6e+02 3.1 0.0 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat ATP-grasp_4 PF13535.1 KOO24099.1 - 2.9e-33 115.1 0.1 5.1e-33 114.3 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.14 KOO24099.1 - 1.1e-10 41.4 0.0 1.1e-07 31.5 0.0 2.3 2 0 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_3 PF02655.9 KOO24099.1 - 6.3e-07 29.3 0.0 1.2e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 KOO24099.1 - 7.4e-06 24.9 0.0 1.7e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 KOO24099.1 - 0.0036 16.7 0.0 0.0059 16.0 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_ST PF14397.1 KOO24099.1 - 0.015 14.3 0.0 1.2 8.2 0.0 2.1 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp CPSase_L_D2 PF02786.12 KOO24099.1 - 0.016 14.5 0.1 0.026 13.8 0.1 1.5 1 1 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Nucleotid_trans PF03407.11 KOO24100.1 - 9.2e-09 35.3 0.1 1.4e-08 34.8 0.1 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase DEAD PF00270.24 KOO24102.1 - 2.2e-42 144.4 0.0 5.1e-40 136.7 0.0 2.1 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO24102.1 - 4.3e-26 90.5 0.0 1.1e-25 89.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO24102.1 - 0.00024 21.0 0.0 0.0022 17.8 0.0 2.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit DUF1253 PF06862.7 KOO24102.1 - 0.0099 14.3 0.0 3.7 5.8 0.0 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF1253) CMS1 PF14617.1 KOO24102.1 - 0.078 12.0 0.0 0.46 9.5 0.0 2.0 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Helicase_C_2 PF13307.1 KOO24102.1 - 0.099 12.5 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Helicase C-terminal domain Thymidylate_kin PF02223.12 KOO24103.1 - 6.2e-16 58.3 0.0 1.4e-15 57.1 0.0 1.6 1 0 0 1 1 1 1 Thymidylate kinase adh_short PF00106.20 KOO24104.1 - 1.5e-38 132.3 2.9 1.5e-38 132.3 2.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 KOO24104.1 - 2.2e-20 73.4 0.5 2.9e-20 73.0 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KOO24104.1 - 4e-18 65.7 1.3 4e-18 65.7 0.9 1.6 2 0 0 2 2 2 1 KR domain Radical_SAM PF04055.16 KOO24104.1 - 0.092 12.9 0.0 0.2 11.8 0.0 1.6 2 0 0 2 2 2 0 Radical SAM superfamily RRM_1 PF00076.17 KOO24105.1 - 0.017 14.7 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) bZIP_1 PF00170.16 KOO24106.1 - 0.05 13.5 0.7 0.05 13.5 0.5 1.9 2 0 0 2 2 2 0 bZIP transcription factor CENP-F_leu_zip PF10473.4 KOO24106.1 - 0.059 13.2 0.7 0.096 12.5 0.5 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIC PF04977.10 KOO24106.1 - 0.31 10.5 1.2 1.1 8.8 0.2 2.1 2 0 0 2 2 2 0 Septum formation initiator Atg14 PF10186.4 KOO24106.1 - 1.4 7.7 2.9 2 7.2 2.0 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF2076 PF09849.4 KOO24106.1 - 1.5 8.7 9.9 0.55 10.2 4.7 1.8 1 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) LRR_6 PF13516.1 KOO24107.1 - 3.5e-12 45.0 3.6 0.17 12.0 0.0 5.9 5 0 0 5 5 5 3 Leucine Rich repeat LRR_1 PF00560.28 KOO24107.1 - 0.012 15.4 1.2 20 5.7 0.1 4.5 4 0 0 4 4 4 0 Leucine Rich Repeat SpoU_sub_bind PF08032.7 KOO24107.1 - 0.027 14.6 0.1 15 5.8 0.0 2.7 3 0 0 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding HTH_40 PF14493.1 KOO24107.1 - 0.029 14.5 0.1 12 6.1 0.0 2.6 3 0 0 3 3 3 0 Helix-turn-helix domain LRR_7 PF13504.1 KOO24107.1 - 0.044 13.9 0.9 2.3e+02 2.7 0.0 4.7 6 0 0 6 6 6 0 Leucine rich repeat LRR_4 PF12799.2 KOO24107.1 - 0.072 12.7 5.8 12 5.6 0.0 3.5 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO24107.1 - 0.081 12.6 1.0 63 3.4 0.0 3.9 3 1 0 3 3 3 0 Leucine rich repeat HORMA PF02301.13 KOO24108.1 - 4.5e-35 121.0 0.0 5.8e-35 120.6 0.0 1.1 1 0 0 1 1 1 1 HORMA domain MarR_2 PF12802.2 KOO24108.1 - 0.0099 15.5 0.8 0.043 13.4 0.6 2.1 1 0 0 1 1 1 1 MarR family HTH_Crp_2 PF13545.1 KOO24108.1 - 0.012 15.3 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_20 PF12840.2 KOO24108.1 - 0.023 14.4 0.5 0.091 12.5 0.4 2.1 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_IclR PF09339.5 KOO24108.1 - 0.053 13.1 0.3 0.12 12.0 0.2 1.6 1 0 0 1 1 1 0 IclR helix-turn-helix domain RNA_pol_Rpo13 PF12136.3 KOO24108.1 - 0.32 10.7 5.0 1.4 8.6 0.6 2.5 2 0 0 2 2 2 0 RNA polymerase Rpo13 subunit HTH domain EF-hand_1 PF00036.27 KOO24109.1 - 7.3e-08 31.1 2.4 0.0044 16.2 0.3 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO24109.1 - 9.8e-07 28.8 4.9 1.8e-05 24.7 0.4 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO24109.1 - 1.3e-05 24.6 3.8 0.066 13.1 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO24109.1 - 0.0001 21.4 2.4 0.0075 15.5 0.3 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO24109.1 - 0.00074 19.0 3.1 0.007 15.9 1.3 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.2 KOO24109.1 - 0.031 14.0 0.5 2.8 7.7 0.1 2.3 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO24109.1 - 0.034 14.1 0.0 0.048 13.6 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Glyco_hydro_2_C PF02836.12 KOO24110.1 - 6e-93 311.0 0.0 7.9e-93 310.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.16 KOO24110.1 - 1.6e-05 25.3 0.0 3.5e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Prok_Ub PF14454.1 KOO24110.1 - 0.16 11.6 0.0 0.39 10.4 0.0 1.6 1 0 0 1 1 1 0 Prokaryotic Ubiquitin DEAD PF00270.24 KOO24111.1 - 3.8e-40 137.1 0.0 8.1e-39 132.8 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO24111.1 - 5.4e-23 80.6 0.1 1.2e-22 79.5 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO24111.1 - 0.022 14.6 0.0 0.061 13.1 0.0 1.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit CMS1 PF14617.1 KOO24111.1 - 0.11 11.5 0.0 0.34 9.9 0.0 1.7 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Sel1 PF08238.7 KOO24112.1 - 2.2e-08 34.4 8.4 0.00066 20.2 0.8 4.4 3 1 1 4 4 4 2 Sel1 repeat DUF3138 PF11336.3 KOO24112.1 - 6.9 4.7 8.7 28 2.7 6.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) HSP70 PF00012.15 KOO24112.1 - 7.6 4.3 11.3 11 3.7 7.8 1.1 1 0 0 1 1 1 0 Hsp70 protein Peptidase_S46 PF10459.4 KOO24112.1 - 9.9 4.4 13.7 14 3.9 9.5 1.2 1 0 0 1 1 1 0 Peptidase S46 Myb_DNA-binding PF00249.26 KOO24113.1 - 1.4e-24 85.8 6.1 7.6e-12 45.1 1.4 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO24113.1 - 2e-23 82.2 5.7 3.2e-17 62.3 0.7 2.5 1 1 1 2 2 2 2 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.4 KOO24113.1 - 3.1e-06 27.2 1.7 0.0032 17.6 0.5 2.3 2 0 0 2 2 2 2 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_4 PF13837.1 KOO24113.1 - 0.035 14.2 2.4 0.12 12.5 0.4 2.4 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Rap1_C PF11626.3 KOO24113.1 - 0.039 13.8 1.1 1.7 8.6 0.8 2.5 1 1 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_2 PF08914.6 KOO24113.1 - 0.044 13.5 0.5 7.6 6.4 0.1 2.4 1 1 1 2 2 2 0 Rap1 Myb domain SNF2_N PF00176.18 KOO24114.1 - 2.4e-07 29.8 0.0 2.8e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain Herpes_pp85 PF04637.7 KOO24114.1 - 2.8 6.1 4.2 3.8 5.7 2.9 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) HA PF03457.9 KOO24115.1 - 0.23 11.5 1.3 1.4 9.0 0.1 2.7 3 0 0 3 3 3 0 Helicase associated domain Recombinase PF07508.8 KOO24117.1 - 0.0016 18.5 0.0 0.0025 17.9 0.0 1.3 1 0 0 1 1 1 1 Recombinase UbiA PF01040.13 KOO24118.1 - 1.3e-29 103.2 30.7 1.8e-29 102.7 21.3 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family TMEM238 PF15125.1 KOO24118.1 - 0.028 14.3 0.5 0.12 12.3 0.4 2.1 1 0 0 1 1 1 0 TMEM238 protein family MIP PF00230.15 KOO24120.1 - 5.9e-30 104.4 12.9 1.9e-29 102.7 5.0 2.1 1 1 1 2 2 2 2 Major intrinsic protein DUF4386 PF14329.1 KOO24121.1 - 0.0044 16.5 3.6 0.0044 16.5 2.5 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4386) Spermine_synth PF01564.12 KOO24122.1 - 4.4e-50 169.9 0.0 6e-50 169.4 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_18 PF12847.2 KOO24122.1 - 0.00013 22.5 0.0 0.00022 21.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO24122.1 - 0.0002 21.3 0.2 0.00044 20.2 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO24122.1 - 0.0014 18.3 0.0 0.0034 17.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO24122.1 - 0.03 14.7 0.0 0.056 13.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain DUF2353 PF09789.4 KOO24123.1 - 0.027 13.7 5.0 0.048 12.9 3.5 1.4 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) DUF607 PF04678.8 KOO24123.1 - 3.4 7.5 5.0 2.5 7.9 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function, DUF607 PITH PF06201.8 KOO24124.1 - 4.4e-38 130.4 0.0 5.4e-38 130.1 0.0 1.1 1 0 0 1 1 1 1 PITH domain Pkinase PF00069.20 KOO24126.1 - 1.2e-72 244.2 0.0 1.4e-72 244.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO24126.1 - 1.7e-50 171.5 0.0 2.1e-50 171.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO24126.1 - 4.1e-07 29.2 0.0 0.00012 21.2 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 KOO24126.1 - 0.00066 19.4 0.0 0.18 11.4 0.0 2.6 2 1 1 3 3 3 2 Phosphotransferase enzyme family Mob1_phocein PF03637.12 KOO24127.1 - 2.6e-70 235.6 0.3 3.4e-70 235.2 0.2 1.2 1 0 0 1 1 1 1 Mob1/phocein family DUF1077 PF06417.7 KOO24127.1 - 1.1e-36 124.9 3.9 1.8e-36 124.2 2.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) WD40 PF00400.27 KOO24128.1 - 1.9e-09 37.0 12.6 0.001 18.8 0.5 5.4 5 1 0 5 5 5 3 WD domain, G-beta repeat PQQ_2 PF13360.1 KOO24128.1 - 0.019 14.4 0.0 0.029 13.8 0.0 1.4 1 0 0 1 1 1 0 PQQ-like domain PQQ PF01011.16 KOO24128.1 - 0.17 11.4 0.9 0.36 10.4 0.1 2.0 2 0 0 2 2 2 0 PQQ enzyme repeat PQQ_3 PF13570.1 KOO24128.1 - 0.76 10.1 4.9 62 4.0 0.0 4.1 4 1 0 4 4 4 0 PQQ-like domain WD40 PF00400.27 KOO24130.1 - 2.1e-36 122.4 16.9 6.5e-10 38.4 0.0 7.4 8 0 0 8 8 8 6 WD domain, G-beta repeat EF-hand_6 PF13405.1 KOO24131.1 - 2e-23 80.0 0.4 1.6e-06 27.5 0.0 4.8 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.27 KOO24131.1 - 3.1e-22 76.1 1.0 2.4e-06 26.4 0.0 4.9 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.1 KOO24131.1 - 5.9e-19 67.9 2.3 3.1e-09 36.8 0.1 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO24131.1 - 4.3e-18 63.7 6.0 2.8e-05 23.2 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO24131.1 - 5.4e-13 48.3 4.1 5.3e-05 22.7 0.3 4.6 3 1 1 4 4 4 3 EF-hand domain pair DUF2624 PF11116.3 KOO24131.1 - 0.0069 16.8 0.0 0.023 15.1 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2624) EF-hand_10 PF14788.1 KOO24131.1 - 0.019 14.6 1.0 17 5.2 0.0 3.7 3 0 0 3 3 3 0 EF hand DEC-1_N PF04625.8 KOO24131.1 - 0.15 10.7 3.7 0.24 10.0 2.6 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region DUF1840 PF08895.6 KOO24131.1 - 0.57 10.2 4.5 0.48 10.4 1.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) PG_binding_2 PF08823.6 KOO24131.1 - 0.97 9.5 4.7 1.2 9.2 0.0 3.4 4 1 0 4 4 4 0 Putative peptidoglycan binding domain PQ-loop PF04193.9 KOO24132.1 - 6e-07 28.9 0.8 6e-07 28.9 0.6 2.0 2 0 0 2 2 2 1 PQ loop repeat XK-related PF09815.4 KOO24132.1 - 0.0022 17.0 5.2 0.0028 16.7 3.6 1.1 1 0 0 1 1 1 1 XK-related protein ER_lumen_recept PF00810.13 KOO24132.1 - 0.14 12.6 3.3 0.19 12.2 2.3 1.2 1 0 0 1 1 1 0 ER lumen protein retaining receptor 7TMR-DISM_7TM PF07695.6 KOO24132.1 - 0.47 10.1 7.0 0.88 9.2 3.9 1.6 1 1 0 1 1 1 0 7TM diverse intracellular signalling EF-hand_6 PF13405.1 KOO24133.1 - 1.9e-11 42.8 0.4 0.0019 17.9 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.27 KOO24133.1 - 1.6e-10 39.5 0.0 0.015 14.5 0.0 3.4 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.1 KOO24133.1 - 2.8e-10 40.1 0.0 7.2e-08 32.4 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO24133.1 - 6.9e-08 31.4 1.0 0.021 14.1 0.2 3.6 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 KOO24133.1 - 0.00023 20.7 0.1 1.7 8.3 0.0 3.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_10 PF14788.1 KOO24133.1 - 0.0045 16.6 0.0 0.14 11.8 0.0 2.4 1 1 1 2 2 2 2 EF hand WD40 PF00400.27 KOO24134.1 - 3.6e-37 124.9 16.9 8.8e-07 28.5 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 KOO24134.1 - 0.00031 19.0 1.2 0.13 10.4 0.0 3.2 3 0 0 3 3 3 3 Nucleoporin Nup120/160 BBS2_Mid PF14783.1 KOO24134.1 - 0.071 12.9 0.0 0.37 10.5 0.0 2.1 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region BRO1 PF03097.13 KOO24135.1 - 3.3e-29 101.7 0.0 3.9e-29 101.5 0.0 1.1 1 0 0 1 1 1 1 BRO1-like domain DOG1 PF14144.1 KOO24135.1 - 0.081 12.9 0.2 0.31 11.1 0.0 2.0 2 1 0 2 2 2 0 Seed dormancy control Sel1 PF08238.7 KOO24135.1 - 0.2 12.3 3.6 11 6.8 0.8 3.4 2 1 1 3 3 3 0 Sel1 repeat PilJ PF13675.1 KOO24135.1 - 0.95 9.8 4.1 96 3.3 1.2 3.2 1 1 2 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term DEAD PF00270.24 KOO24136.1 - 9.9e-44 148.8 0.0 1.9e-43 147.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO24136.1 - 3.5e-25 87.6 0.9 2.3e-24 85.0 0.1 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SRP_SPB PF02978.14 KOO24136.1 - 7.5e-08 32.5 0.1 1.7e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 Signal peptide binding domain CMS1 PF14617.1 KOO24136.1 - 0.00014 21.0 0.0 0.00035 19.7 0.0 1.6 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.10 KOO24136.1 - 0.0025 17.6 0.0 0.0069 16.2 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit GUCT PF08152.7 KOO24136.1 - 0.0045 16.9 0.1 0.014 15.3 0.0 1.8 1 0 0 1 1 1 1 GUCT (NUC152) domain Apolipoprotein PF01442.13 KOO24138.1 - 0.0021 17.6 0.4 0.0044 16.5 0.3 1.6 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain DUF3135 PF11333.3 KOO24138.1 - 0.37 10.9 2.1 16 5.7 0.4 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3135) Ubiq_cyt_C_chap PF03981.7 KOO24138.1 - 0.56 10.0 4.2 0.46 10.3 1.3 2.0 2 1 0 2 2 2 0 Ubiquinol-cytochrome C chaperone Abhydrolase_6 PF12697.2 KOO24139.1 - 0.0007 19.5 0.5 0.00091 19.1 0.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO24139.1 - 0.06 12.8 0.0 0.13 11.8 0.0 1.5 2 0 0 2 2 2 0 alpha/beta hydrolase fold NAD_binding_8 PF13450.1 KOO24141.1 - 6.2e-08 32.5 0.0 2.1e-07 30.8 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.22 KOO24141.1 - 0.0003 21.1 0.0 0.0012 19.1 0.0 2.1 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 KOO24141.1 - 0.00044 19.2 0.1 0.0012 17.8 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 KOO24141.1 - 0.00064 19.6 0.0 0.0013 18.6 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 KOO24141.1 - 0.013 14.5 0.0 0.056 12.5 0.0 1.9 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase GIDA PF01134.17 KOO24141.1 - 0.017 14.0 0.1 0.027 13.3 0.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.16 KOO24141.1 - 0.02 14.4 0.2 0.035 13.6 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.9 KOO24141.1 - 0.055 12.1 0.3 0.084 11.4 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase HI0933_like PF03486.9 KOO24141.1 - 0.055 11.9 0.1 0.078 11.4 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein FAD_binding_3 PF01494.14 KOO24141.1 - 0.058 12.4 0.1 0.13 11.2 0.1 1.5 1 0 0 1 1 1 0 FAD binding domain FAD_binding_2 PF00890.19 KOO24141.1 - 0.06 12.1 0.3 0.18 10.6 0.0 1.9 3 0 0 3 3 3 0 FAD binding domain FAD_oxidored PF12831.2 KOO24141.1 - 0.1 11.6 0.2 0.15 11.0 0.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.13 KOO24141.1 - 0.11 12.1 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HycI PF01750.13 KOO24141.1 - 0.11 12.0 0.0 0.29 10.6 0.0 1.6 2 0 0 2 2 2 0 Hydrogenase maturation protease NAD_binding_7 PF13241.1 KOO24141.1 - 0.14 12.4 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Thi4 PF01946.12 KOO24141.1 - 0.2 10.7 0.0 0.42 9.6 0.0 1.5 1 0 0 1 1 1 0 Thi4 family Fer2 PF00111.22 KOO24143.1 - 0.00055 19.6 0.1 0.003 17.2 0.1 2.2 3 0 0 3 3 3 1 2Fe-2S iron-sulfur cluster binding domain ELO PF01151.13 KOO24145.1 - 1.8e-63 214.1 20.3 2.4e-63 213.7 14.1 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family Arm PF00514.18 KOO24146.1 - 1.7e-225 722.3 170.9 2.9e-08 33.2 0.0 62.1 64 0 0 64 64 64 44 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO24146.1 - 2.3e-43 146.3 207.5 0.00051 20.2 1.1 28.4 8 5 20 32 32 32 26 HEAT repeats Arm_2 PF04826.8 KOO24146.1 - 6.9e-24 84.3 13.2 0.0013 17.8 0.0 17.0 12 6 6 21 21 21 6 Armadillo-like Atx10homo_assoc PF09759.4 KOO24146.1 - 5.4e-18 64.6 0.1 0.00044 19.9 0.0 10.0 10 1 1 11 11 11 3 Spinocerebellar ataxia type 10 protein domain V-ATPase_H_N PF03224.9 KOO24146.1 - 3.7e-16 59.1 0.1 0.055 12.5 0.0 11.3 7 5 0 9 9 9 4 V-ATPase subunit H Adaptin_N PF01602.15 KOO24146.1 - 2.3e-11 42.7 17.5 0.38 9.0 0.0 11.6 10 3 1 13 13 13 5 Adaptin N terminal region HEAT PF02985.17 KOO24146.1 - 1.7e-08 33.8 49.6 9.2 6.6 0.0 21.3 25 0 0 25 25 25 2 HEAT repeat KAP PF05804.7 KOO24146.1 - 0.0064 14.4 0.0 12 3.6 0.0 5.2 7 0 0 7 7 7 1 Kinesin-associated protein (KAP) N1221 PF07923.8 KOO24146.1 - 0.79 8.5 0.0 3.2e+02 -0.1 0.0 4.8 6 0 0 6 6 6 0 N1221-like protein EXOSC1 PF10447.4 KOO24147.1 - 1.4e-13 50.6 0.0 2.6e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Exosome component EXOSC1/CSL4 S1 PF00575.18 KOO24147.1 - 0.022 14.8 0.0 0.083 12.9 0.0 1.9 2 0 0 2 2 2 0 S1 RNA binding domain ECR1_N PF14382.1 KOO24147.1 - 0.05 12.9 0.1 0.31 10.3 0.0 2.4 2 1 0 2 2 2 0 Exosome complex exonuclease RRP4 N-terminal region TauD PF02668.11 KOO24148.1 - 4.8e-36 124.7 0.1 6e-36 124.4 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Ras PF00071.17 KOO24150.1 - 1.7e-08 33.9 0.0 2.3e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO24150.1 - 1.6e-06 28.5 0.0 2.2e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO24150.1 - 0.00039 19.7 0.0 0.00061 19.0 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KOO24150.1 - 0.0023 17.1 0.0 0.0048 16.0 0.0 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA PF00004.24 KOO24150.1 - 0.07 13.3 0.0 0.081 13.1 0.0 1.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 KOO24150.1 - 0.1 12.5 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain TMF_DNA_bd PF12329.3 KOO24151.1 - 0.055 13.2 0.5 0.097 12.4 0.3 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Tropomyosin_1 PF12718.2 KOO24151.1 - 0.072 12.9 0.7 0.11 12.3 0.5 1.2 1 0 0 1 1 1 0 Tropomyosin like MscS_porin PF12795.2 KOO24151.1 - 0.1 11.9 7.0 0.16 11.3 4.9 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain CENP-Q PF13094.1 KOO24151.1 - 0.22 11.5 2.8 0.37 10.8 1.9 1.4 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit HSCB_C PF07743.8 KOO24151.1 - 0.45 11.0 2.7 0.88 10.0 0.8 2.2 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain MbeD_MobD PF04899.7 KOO24151.1 - 0.55 10.1 7.2 0.23 11.3 3.1 1.8 2 0 0 2 2 2 0 MbeD/MobD like IQ PF00612.22 KOO24152.1 - 0.0039 16.7 3.0 0.063 12.9 0.4 3.9 4 0 0 4 4 4 2 IQ calmodulin-binding motif cNMP_binding PF00027.24 KOO24153.1 - 1.6e-54 181.6 0.0 5.4e-19 67.8 0.0 4.6 4 1 0 4 4 4 4 Cyclic nucleotide-binding domain Cupin_2 PF07883.6 KOO24153.1 - 0.021 14.3 3.2 0.11 11.9 0.2 3.1 3 0 0 3 3 3 0 Cupin domain DUF4343 PF14243.1 KOO24153.1 - 0.042 13.6 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4343) Sel1 PF08238.7 KOO24154.1 - 6.8e-14 51.9 9.6 1.5e-05 25.4 0.1 4.1 4 0 0 4 4 4 3 Sel1 repeat U-box PF04564.10 KOO24154.1 - 3.3e-11 42.9 0.0 7.1e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO24154.1 - 0.00012 21.5 0.0 0.00028 20.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Chloroa_b-bind PF00504.16 KOO24155.1 - 2.4e-29 102.5 0.4 3.2e-29 102.1 0.3 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Robl_LC7 PF03259.12 KOO24156.1 - 1.4e-08 34.1 1.5 1.5e-08 34.0 0.0 1.8 2 0 0 2 2 2 1 Roadblock/LC7 domain Arm PF00514.18 KOO24158.1 - 4.6e-14 51.6 31.8 0.025 14.4 0.0 10.6 12 0 0 12 12 12 6 Armadillo/beta-catenin-like repeat V-ATPase_H_N PF03224.9 KOO24158.1 - 0.0053 15.9 0.0 0.63 9.1 0.0 2.5 2 0 0 2 2 2 2 V-ATPase subunit H KAP PF05804.7 KOO24158.1 - 0.33 8.8 0.1 0.87 7.4 0.0 1.7 2 0 0 2 2 2 0 Kinesin-associated protein (KAP) AAA_13 PF13166.1 KOO24158.1 - 3.4 6.0 4.5 5.8 5.2 3.1 1.2 1 0 0 1 1 1 0 AAA domain Nbl1_Borealin_N PF10444.4 KOO24159.1 - 0.046 13.0 0.1 0.15 11.4 0.0 1.8 1 0 0 1 1 1 0 Nbl1 / Borealin N terminal Kinesin PF00225.18 KOO24160.1 - 9.7e-102 340.0 0.0 1.2e-101 339.8 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain UQ_con PF00179.21 KOO24162.1 - 1.4e-26 92.6 0.0 1.8e-26 92.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KOO24162.1 - 3.4e-06 26.8 0.0 5.2e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 KOO24162.1 - 0.0071 16.2 0.0 0.011 15.6 0.0 1.4 1 1 0 1 1 1 1 RWD domain WD40 PF00400.27 KOO24163.1 - 5.2e-15 54.6 4.9 5.7e-05 22.8 0.0 4.5 5 0 0 5 5 5 3 WD domain, G-beta repeat Raptor_N PF14538.1 KOO24165.1 - 6.3e-59 198.2 0.0 9e-59 197.7 0.0 1.1 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain CRISPR_Cse1 PF09481.5 KOO24167.1 - 0.063 12.0 5.3 0.071 11.8 3.7 1.1 1 0 0 1 1 1 0 CRISPR-associated protein Cse1 (CRISPR_cse1) DnaI_N PF07319.6 KOO24167.1 - 0.14 12.4 0.7 0.28 11.4 0.5 1.6 1 0 0 1 1 1 0 Primosomal protein DnaI N-terminus HMG_box_5 PF14887.1 KOO24167.1 - 0.14 11.9 6.4 0.21 11.4 3.7 1.9 1 1 0 1 1 1 0 HMG (high mobility group) box 5 Pilt PF15453.1 KOO24167.1 - 0.73 9.4 5.1 0.92 9.1 3.5 1.1 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions UPF0020 PF01170.13 KOO24169.1 - 3.1e-13 49.7 0.0 6e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_26 PF13659.1 KOO24169.1 - 3.3e-12 46.4 2.2 5.5e-12 45.7 0.2 2.4 3 0 0 3 3 3 1 Methyltransferase domain N6_N4_Mtase PF01555.13 KOO24169.1 - 0.00082 18.9 0.0 0.033 13.6 0.0 2.2 2 0 0 2 2 2 1 DNA methylase N6_Mtase PF02384.11 KOO24169.1 - 0.015 14.3 0.0 0.16 11.0 0.0 2.0 2 0 0 2 2 2 0 N-6 DNA Methylase FMN_bind_2 PF04299.7 KOO24171.1 - 0.15 11.5 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Putative FMN-binding domain EF-hand_1 PF00036.27 KOO24172.1 - 3.4e-31 104.1 12.7 0.00041 19.4 0.2 7.4 7 0 0 7 7 7 7 EF hand EF-hand_6 PF13405.1 KOO24172.1 - 2.9e-26 88.9 8.5 0.00048 19.7 0.1 7.4 7 0 0 7 7 7 6 EF-hand domain EF-hand_7 PF13499.1 KOO24172.1 - 3.9e-25 87.7 12.6 2.2e-07 30.9 0.2 5.6 2 1 3 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.1 KOO24172.1 - 2.4e-19 67.7 11.4 0.00014 21.0 0.0 7.5 7 0 0 7 7 7 5 EF hand EF-hand_8 PF13833.1 KOO24172.1 - 1.8e-12 46.6 14.5 0.0002 20.9 0.3 6.7 6 1 1 7 7 7 5 EF-hand domain pair EF-hand_4 PF12763.2 KOO24172.1 - 0.0027 17.4 5.8 2.6 7.8 0.0 4.9 4 1 1 5 5 5 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO24172.1 - 0.0047 16.9 0.1 0.44 10.5 0.0 3.6 4 0 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region Mg_trans_NIPA PF05653.9 KOO24174.1 - 4.5e-15 55.3 15.4 4.1e-14 52.2 10.6 2.1 1 1 0 1 1 1 1 Magnesium transporter NIPA DUF1183 PF06682.7 KOO24174.1 - 0.0031 17.1 0.7 0.005 16.4 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1183) TPR_11 PF13414.1 KOO24175.1 - 1.9e-20 72.2 28.8 4.7e-09 35.7 5.1 5.8 4 2 2 6 6 6 4 TPR repeat DnaJ PF00226.26 KOO24175.1 - 4.6e-19 67.9 0.9 1e-18 66.8 0.7 1.6 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.12 KOO24175.1 - 2.4e-12 45.7 32.6 0.0045 16.7 0.2 7.5 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_1 PF00515.23 KOO24175.1 - 1.5e-10 40.2 24.3 0.008 15.7 0.3 7.0 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_19 PF14559.1 KOO24175.1 - 1.4e-09 38.1 23.9 0.011 16.0 0.0 6.1 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO24175.1 - 5.3e-06 26.9 58.1 0.02 15.5 0.0 7.8 5 3 3 8 8 7 6 Tetratricopeptide repeat TPR_12 PF13424.1 KOO24175.1 - 6.6e-06 25.9 30.8 0.0046 16.8 0.3 6.5 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO24175.1 - 8.9e-05 22.2 22.8 0.0001 22.0 5.8 5.0 2 2 3 5 5 5 2 Tetratricopeptide repeat Inhibitor_I34 PF10466.4 KOO24175.1 - 0.00067 19.6 0.4 0.0025 17.8 0.1 2.0 2 0 0 2 2 2 1 Saccharopepsin inhibitor I34 TPR_14 PF13428.1 KOO24175.1 - 0.0011 19.3 50.7 0.38 11.5 0.1 8.8 5 4 2 8 8 8 3 Tetratricopeptide repeat Apc3 PF12895.2 KOO24175.1 - 0.0056 16.7 0.0 0.0056 16.7 0.0 4.0 4 1 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 KOO24175.1 - 8.8 6.4 16.2 12 5.9 0.0 5.9 6 0 0 6 6 6 0 Tetratricopeptide repeat Sulfate_transp PF00916.15 KOO24176.1 - 1.9e-40 138.6 12.1 5.1e-29 101.1 1.5 2.5 2 0 0 2 2 2 2 Sulfate transporter family FA_desaturase PF00487.19 KOO24176.1 - 2.3e-33 115.7 13.3 2.3e-33 115.7 9.2 2.3 2 0 0 2 2 2 1 Fatty acid desaturase Sulfate_tra_GLY PF13792.1 KOO24176.1 - 8.8e-25 86.1 1.1 8.8e-25 86.1 0.7 3.0 3 0 0 3 3 3 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 KOO24176.1 - 6.5e-11 41.6 0.0 1.2e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 STAS domain Cyt-b5 PF00173.23 KOO24176.1 - 5.9e-06 25.9 0.0 1.4e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain STAS_2 PF13466.1 KOO24176.1 - 0.053 13.5 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 STAS domain PI3_PI4_kinase PF00454.22 KOO24177.1 - 2.3e-33 115.6 0.0 7.4e-33 113.9 0.0 1.9 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase NUC194 PF08163.7 KOO24177.1 - 5.8e-12 45.1 0.0 1.8e-05 23.8 0.0 2.3 2 0 0 2 2 2 2 NUC194 domain R3H PF01424.17 KOO24177.1 - 3.1e-11 42.8 0.5 8.3e-11 41.4 0.3 1.8 1 0 0 1 1 1 1 R3H domain FAT PF02259.18 KOO24177.1 - 4e-08 32.6 0.8 7.8e-08 31.6 0.1 1.8 2 0 0 2 2 2 1 FAT domain Aldo_ket_red PF00248.16 KOO24178.1 - 9.1e-18 64.0 0.0 1.3e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Abhydrolase_2 PF02230.11 KOO24178.1 - 5.8e-08 32.4 0.0 1.1e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 KOO24178.1 - 6.5e-05 22.7 0.1 0.0014 18.3 0.0 2.9 2 1 0 2 2 2 1 Alpha/beta hydrolase family PALP PF00291.20 KOO24179.1 - 1.3e-31 109.9 1.1 1.5e-31 109.8 0.8 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Ank PF00023.25 KOO24180.1 - 4.5e-12 45.1 0.4 5.2e-10 38.6 0.2 2.4 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.1 KOO24180.1 - 1.9e-11 43.7 0.1 3.5e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO24180.1 - 3.1e-11 43.4 0.0 6.5e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO24180.1 - 3.9e-11 43.1 0.0 6.3e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) PX PF00787.19 KOO24180.1 - 3.1e-10 39.8 0.0 4.9e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 PX domain Ank_3 PF13606.1 KOO24180.1 - 8e-09 34.9 0.1 5.4e-07 29.2 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat EF-hand_7 PF13499.1 KOO24181.1 - 4.5e-17 61.9 3.1 2.4e-08 33.9 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO24181.1 - 5.6e-16 56.5 7.8 6.4e-05 21.9 0.2 4.8 4 1 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 KOO24181.1 - 4.2e-14 51.0 9.1 0.0005 19.7 0.0 4.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.1 KOO24181.1 - 8.5e-09 34.3 9.2 0.0003 19.9 0.3 4.5 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.1 KOO24181.1 - 1.8e-08 33.8 6.6 7.1e-07 28.7 0.1 3.8 2 2 2 4 4 4 1 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO24181.1 - 6.4e-05 22.9 0.0 0.41 10.6 0.0 2.5 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO24181.1 - 0.0035 17.0 0.5 0.015 15.0 0.1 2.2 2 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO24181.1 - 0.0052 16.6 0.1 1.7 8.5 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain S_100 PF01023.14 KOO24181.1 - 0.053 12.8 1.7 0.57 9.5 0.0 3.4 4 0 0 4 4 4 0 S-100/ICaBP type calcium binding domain AP2 PF00847.15 KOO24182.1 - 4.8e-09 36.2 18.5 0.0044 17.1 0.0 5.5 5 0 0 5 5 5 3 AP2 domain MBD PF01429.14 KOO24182.1 - 1.6e-07 30.7 0.0 7.3e-07 28.6 0.0 2.1 1 0 0 1 1 1 1 Methyl-CpG binding domain IF3_N PF05198.11 KOO24182.1 - 0.016 15.1 0.3 23 5.0 0.0 3.5 3 0 0 3 3 3 0 Translation initiation factor IF-3, N-terminal domain T2SS-T3SS_pil_N PF13629.1 KOO24182.1 - 0.04 13.4 0.0 0.091 12.2 0.0 1.5 1 0 0 1 1 1 0 Pilus formation protein N terminal region E1-E2_ATPase PF00122.15 KOO24184.1 - 6.3e-20 71.1 0.3 2.1e-14 53.1 0.0 2.7 2 0 0 2 2 2 2 E1-E2 ATPase Hydrolase PF00702.21 KOO24184.1 - 3.6e-17 63.5 10.0 7e-15 56.0 3.1 3.9 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO24184.1 - 7.9e-13 48.9 0.2 1.2e-11 45.1 0.1 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 KOO24184.1 - 0.014 14.9 0.1 0.025 14.1 0.1 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Sec23_helical PF04815.10 KOO24185.1 - 2.3e-18 65.5 0.0 3.6e-18 64.8 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 KOO24185.1 - 7.7e-07 29.5 0.0 1.3e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.17 KOO24185.1 - 0.13 11.9 0.0 0.65 9.7 0.0 2.0 1 1 0 1 1 1 0 Gelsolin repeat DUF4337 PF14235.1 KOO24186.1 - 0.0028 17.5 1.8 0.0069 16.2 1.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4337) DUF4011 PF13195.1 KOO24186.1 - 7.2 6.5 6.3 1.1 9.3 1.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4011) Exostosin PF03016.10 KOO24188.1 - 8.2e-10 38.2 0.0 1.1e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 Exostosin family Tudor-knot PF11717.3 KOO24191.1 - 0.0026 17.4 0.1 0.0054 16.3 0.0 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain MBT PF02820.13 KOO24191.1 - 0.015 15.1 0.2 0.03 14.2 0.1 1.4 1 0 0 1 1 1 0 mbt repeat AAA PF00004.24 KOO24192.1 - 3.7e-16 59.5 0.0 6.2e-16 58.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.6 KOO24192.1 - 1.4e-13 50.6 0.0 3.9e-13 49.2 0.0 1.8 2 0 0 2 2 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 KOO24192.1 - 8e-13 48.3 0.0 9.5e-10 38.3 0.1 2.3 1 1 1 2 2 2 2 DNA polymerase III, delta subunit Rad17 PF03215.10 KOO24192.1 - 1.6e-07 30.4 0.0 1.7e-06 27.0 0.0 2.1 1 1 1 2 2 2 1 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 KOO24192.1 - 5.8e-06 26.4 0.4 0.14 12.2 0.1 2.6 1 1 1 2 2 2 2 AAA domain AAA_14 PF13173.1 KOO24192.1 - 1.6e-05 24.8 0.0 2.4e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOO24192.1 - 3.8e-05 23.3 0.0 0.00018 21.1 0.0 2.1 2 0 0 2 2 2 1 Part of AAA domain RuvB_N PF05496.7 KOO24192.1 - 9.6e-05 21.5 0.0 0.00022 20.3 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 KOO24192.1 - 0.00029 20.8 0.0 0.00076 19.5 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.8 KOO24192.1 - 0.00047 19.1 0.0 0.00078 18.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_11 PF13086.1 KOO24192.1 - 0.0005 19.7 0.0 0.001 18.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 KOO24192.1 - 0.0021 17.8 0.0 0.005 16.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 KOO24192.1 - 0.0022 17.4 0.3 0.02 14.2 0.1 2.4 2 1 0 2 2 2 1 AAA domain AAA_10 PF12846.2 KOO24192.1 - 0.004 16.6 0.4 0.91 8.8 0.0 2.3 1 1 1 2 2 2 1 AAA-like domain Arch_ATPase PF01637.13 KOO24192.1 - 0.006 16.3 0.0 0.0085 15.8 0.0 1.2 1 0 0 1 1 1 1 Archaeal ATPase IstB_IS21 PF01695.12 KOO24192.1 - 0.022 14.1 0.0 0.066 12.6 0.0 1.8 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.1 KOO24192.1 - 0.024 14.2 0.0 0.041 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 KOO24192.1 - 0.027 14.0 0.0 0.29 10.7 0.0 2.2 1 1 0 1 1 1 0 AAA domain DEAD PF00270.24 KOO24192.1 - 0.038 13.4 0.1 1.5 8.2 0.0 2.8 1 1 2 3 3 3 0 DEAD/DEAH box helicase AAA_3 PF07726.6 KOO24192.1 - 0.078 12.5 0.0 0.2 11.2 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SNF2_N PF00176.18 KOO24192.1 - 0.081 11.7 0.1 6.9 5.3 0.0 2.7 2 1 1 3 3 3 0 SNF2 family N-terminal domain Mg_chelatase PF01078.16 KOO24192.1 - 0.11 11.6 0.1 0.24 10.5 0.1 1.6 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF1348 PF07080.6 KOO24193.1 - 0.011 15.5 0.5 0.038 13.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1348) EGF_CA PF07645.10 KOO24194.1 - 2e-13 50.0 22.3 4.5e-09 36.1 3.8 3.3 3 0 0 3 3 3 2 Calcium-binding EGF domain Arm PF00514.18 KOO24194.1 - 9.8e-09 34.7 2.0 0.0015 18.2 0.4 2.8 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat EGF_3 PF12947.2 KOO24194.1 - 0.00061 19.6 23.5 0.012 15.5 3.0 3.4 3 0 0 3 3 3 2 EGF domain DUF4215 PF13948.1 KOO24194.1 - 0.0027 17.8 1.6 0.0027 17.8 1.1 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4215) EGF PF00008.22 KOO24194.1 - 0.0055 16.6 18.9 0.15 12.0 4.6 2.8 2 0 0 2 2 2 2 EGF-like domain Alkyl_sulf_dimr PF14863.1 KOO24194.1 - 0.03 14.5 5.1 0.27 11.4 3.5 2.3 1 1 0 1 1 1 0 Alkyl sulfatase dimerisation cEGF PF12662.2 KOO24194.1 - 0.47 10.1 9.6 5.4 6.7 0.0 4.4 4 0 0 4 4 4 0 Complement Clr-like EGF-like TIG PF01833.19 KOO24195.1 - 1.2e-44 150.2 30.3 8.1e-11 41.7 0.0 6.1 5 0 0 5 5 5 5 IPT/TIG domain G8 PF10162.4 KOO24195.1 - 3e-21 75.5 0.0 1e-20 73.8 0.0 2.0 1 0 0 1 1 1 1 G8 domain F5_F8_type_C PF00754.20 KOO24195.1 - 8.3e-05 22.4 0.0 0.0002 21.1 0.0 1.6 1 0 0 1 1 1 1 F5/8 type C domain Beta_helix PF13229.1 KOO24195.1 - 0.00045 20.0 12.8 3.5 7.3 8.9 3.5 1 1 0 1 1 1 1 Right handed beta helix region CS PF04969.11 KOO24197.1 - 4.6e-06 27.0 0.1 6.8e-06 26.5 0.1 1.3 1 0 0 1 1 1 1 CS domain DUF995 PF06191.7 KOO24197.1 - 0.087 12.2 0.0 0.087 12.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF995) zf-MYND PF01753.13 KOO24198.1 - 4.2e-07 29.7 8.9 4.2e-07 29.7 6.2 1.7 2 0 0 2 2 2 1 MYND finger peroxidase PF00141.18 KOO24199.1 - 6.9e-37 127.1 0.0 1.4e-36 126.1 0.0 1.5 1 1 0 1 1 1 1 Peroxidase NAD_binding_1 PF00175.16 KOO24199.1 - 4.4e-18 65.8 0.0 7.8e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 KOO24199.1 - 1.4e-11 44.3 0.0 2.4e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain EF-hand_1 PF00036.27 KOO24200.1 - 4.4e-39 128.7 12.7 2.4e-05 23.3 0.1 7.8 7 0 0 7 7 7 7 EF hand EF-hand_7 PF13499.1 KOO24200.1 - 1.6e-29 101.8 15.7 7.3e-08 32.4 0.5 4.6 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO24200.1 - 9.3e-29 96.7 25.5 0.00045 19.8 0.0 8.6 9 0 0 9 9 9 7 EF-hand domain EF-hand_8 PF13833.1 KOO24200.1 - 5.7e-24 83.4 18.2 7.5e-08 31.8 0.2 6.4 4 3 3 7 7 7 5 EF-hand domain pair EF-hand_5 PF13202.1 KOO24200.1 - 2.9e-23 80.1 11.9 0.0046 16.2 0.0 7.4 7 0 0 7 7 7 6 EF hand EF-hand_4 PF12763.2 KOO24200.1 - 1.3e-08 34.4 4.1 0.27 10.9 0.1 5.6 4 2 2 6 6 6 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO24200.1 - 4.1e-06 26.6 0.4 0.12 12.2 0.0 4.2 4 0 0 4 4 4 1 EF-hand domain EF-hand_10 PF14788.1 KOO24200.1 - 3.1e-05 23.5 6.2 0.02 14.5 0.1 5.0 3 2 2 5 5 5 1 EF hand SPARC_Ca_bdg PF10591.4 KOO24200.1 - 0.0074 16.2 0.1 1.1 9.2 0.0 3.3 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region p25-alpha PF05517.7 KOO24200.1 - 0.0075 16.5 2.1 0.93 9.7 0.3 2.6 2 0 0 2 2 2 1 p25-alpha VCBS PF13517.1 KOO24201.1 - 6.7e-124 404.3 159.7 6.7e-14 51.9 4.4 13.4 1 1 12 13 13 13 13 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO24201.1 - 9.3e-66 216.1 163.1 1.9e-05 24.1 3.2 14.5 14 0 0 14 14 14 14 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO24201.1 - 2.5e-18 66.1 64.6 0.71 9.2 0.2 14.2 1 1 13 14 14 14 14 Insecticide toxin TcdB middle/N-terminal region Phage_AlpA PF05930.7 KOO24201.1 - 0.019 14.6 0.0 54 3.6 0.0 4.8 6 0 0 6 6 6 0 Prophage CP4-57 regulatory protein (AlpA) Ion_trans PF00520.26 KOO24202.1 - 2.7e-31 108.3 15.5 3.9e-31 107.8 10.8 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.7 KOO24202.1 - 0.0082 14.6 13.4 0.011 14.1 4.1 2.4 2 1 1 3 3 3 2 Polycystin cation channel Herpes_UL37_2 PF07413.6 KOO24202.1 - 0.27 9.9 0.8 1.1 7.9 0.5 1.9 2 0 0 2 2 2 0 Betaherpesvirus immediate-early glycoprotein UL37 ABC1 PF03109.11 KOO24203.1 - 0.0036 17.2 0.0 0.0074 16.2 0.0 1.4 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 KOO24203.1 - 0.011 15.4 1.5 0.014 15.0 0.3 2.0 2 1 0 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.17 KOO24203.1 - 0.054 12.8 0.0 0.17 11.2 0.0 1.7 2 0 0 2 2 2 0 RIO1 family DUF2849 PF11011.3 KOO24203.1 - 0.097 12.9 3.9 0.26 11.5 0.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2849) WD40 PF00400.27 KOO24204.1 - 3.1e-24 83.9 34.5 1.9e-05 24.3 0.1 10.2 12 0 0 12 12 12 6 WD domain, G-beta repeat PQQ_3 PF13570.1 KOO24204.1 - 0.00091 19.4 6.7 0.083 13.2 0.1 4.8 5 0 0 5 5 5 1 PQQ-like domain PQQ_2 PF13360.1 KOO24204.1 - 0.00097 18.6 0.1 0.38 10.1 0.0 3.2 2 1 0 2 2 2 1 PQQ-like domain Cytochrom_D1 PF02239.11 KOO24204.1 - 0.0024 16.2 0.0 0.1 10.8 0.0 2.8 3 1 0 3 3 3 1 Cytochrome D1 heme domain PQQ PF01011.16 KOO24204.1 - 0.003 16.9 0.1 0.15 11.6 0.0 3.1 2 0 0 2 2 2 1 PQQ enzyme repeat Nup160 PF11715.3 KOO24204.1 - 0.0038 15.4 0.1 0.01 13.9 0.1 1.7 1 1 0 1 1 1 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 KOO24204.1 - 0.0079 14.9 0.0 0.74 8.4 0.0 3.1 3 1 0 3 3 3 1 Nup133 N terminal like Hira PF07569.6 KOO24204.1 - 0.04 13.1 0.0 1.5 7.9 0.0 2.8 2 0 0 2 2 2 0 TUP1-like enhancer of split zf-H2C2_2 PF13465.1 KOO24205.1 - 5.3e-31 105.3 46.9 7e-07 29.2 0.3 7.1 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.21 KOO24205.1 - 9.1e-30 101.1 51.2 2.1e-05 24.5 0.8 6.7 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOO24205.1 - 8.4e-22 75.8 40.6 0.00011 22.2 0.5 7.0 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_6 PF13912.1 KOO24205.1 - 0.033 14.1 28.5 0.07 13.0 0.2 6.4 6 0 0 6 6 6 0 C2H2-type zinc finger zf-met PF12874.2 KOO24205.1 - 0.063 13.4 18.3 1.1 9.5 0.0 5.5 5 0 0 5 5 5 0 Zinc-finger of C2H2 type IQ PF00612.22 KOO24205.1 - 0.065 12.9 4.0 1.9 8.3 0.1 2.7 2 0 0 2 2 2 0 IQ calmodulin-binding motif zf-C2H2_jaz PF12171.3 KOO24205.1 - 0.76 10.0 28.1 0.35 11.0 0.5 5.8 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding CCAP PF11105.3 KOO24205.1 - 1.4 8.6 13.7 13 5.5 0.6 4.0 2 1 2 4 4 4 0 Arthropod cardioacceleratory peptide 2a SBBP PF06739.6 KOO24205.1 - 7.7 6.3 33.8 0.81 9.5 2.9 4.9 5 0 0 5 5 5 0 Beta-propeller repeat TRI9 PF08195.6 KOO24206.1 - 0.00039 19.9 1.0 0.36 10.4 0.1 3.2 3 1 1 4 4 4 2 TRI9 protein Luteo_PO PF04662.8 KOO24206.1 - 0.1 12.0 1.2 23 4.3 0.0 3.2 1 1 3 4 4 4 0 Luteovirus P0 protein SET PF00856.23 KOO24207.1 - 3.7e-09 37.0 0.1 8.9e-08 32.6 0.0 2.1 1 1 0 1 1 1 1 SET domain NmrA PF05368.8 KOO24208.1 - 1e-22 80.5 0.4 1.3e-22 80.2 0.3 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 KOO24208.1 - 1.6e-17 64.0 0.3 2.8e-17 63.3 0.2 1.4 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 KOO24208.1 - 0.081 12.3 0.1 0.11 11.8 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Voltage_CLC PF00654.15 KOO24209.1 - 4e-48 164.2 41.7 6.4e-34 117.5 14.8 2.8 2 1 1 3 3 3 2 Voltage gated chloride channel DUF3529 PF12046.3 KOO24209.1 - 3.6 6.5 6.9 2 7.4 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3529) Cyclin_N PF00134.18 KOO24210.1 - 3.5e-49 165.5 1.2 9.1e-49 164.2 0.2 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 KOO24210.1 - 1.3e-31 108.9 0.3 2.4e-31 108.1 0.2 1.4 1 0 0 1 1 1 1 Cyclin, C-terminal domain Ndc80_HEC PF03801.8 KOO24210.1 - 0.14 11.5 0.0 0.42 10.0 0.0 1.6 1 1 1 2 2 2 0 HEC/Ndc80p family Cupin_8 PF13621.1 KOO24212.1 - 2.5e-15 56.6 0.1 3.6e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 KOO24212.1 - 8.3e-06 25.2 0.0 1e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Cupin superfamily protein Semialdhyde_dh PF01118.19 KOO24212.1 - 0.046 14.0 0.0 0.073 13.3 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Man-6-P_recep PF02157.10 KOO24213.1 - 1.1e-07 31.1 0.0 1.6e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.5 KOO24213.1 - 1.2e-07 31.2 0.0 5.1e-07 29.2 0.0 1.8 2 0 0 2 2 2 1 Autophagy-related protein 27 KCNQC3-Ank-G_bd PF11956.3 KOO24213.1 - 0.057 13.4 0.2 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 Ankyrin-G binding motif of KCNQ2-3 DUF2648 PF10855.3 KOO24213.1 - 0.08 12.3 2.9 0.12 11.8 1.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2648) DUF4023 PF13215.1 KOO24213.1 - 0.23 11.2 0.9 0.37 10.5 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4023) Ion_trans PF00520.26 KOO24214.1 - 4.2e-07 29.4 8.1 5.6e-07 29.0 5.6 1.2 1 0 0 1 1 1 1 Ion transport protein EF-hand_5 PF13202.1 KOO24214.1 - 2.9e-06 26.3 0.6 6.1e-06 25.3 0.4 1.6 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KOO24214.1 - 1e-05 24.4 0.3 1.9e-05 23.5 0.2 1.5 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO24214.1 - 2.1e-05 24.5 0.0 2.8e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO24214.1 - 6.7e-05 22.4 0.1 0.00014 21.4 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.1 KOO24214.1 - 0.012 15.2 0.1 0.021 14.4 0.1 1.4 1 0 0 1 1 1 0 EF-hand domain pair PEMT PF04191.8 KOO24214.1 - 0.24 11.4 4.4 0.6 10.2 3.1 1.7 1 1 0 1 1 1 0 Phospholipid methyltransferase COX4_pro_2 PF07835.7 KOO24214.1 - 0.38 10.7 5.3 3.2 7.7 1.4 2.6 2 0 0 2 2 2 0 Bacterial aa3 type cytochrome c oxidase subunit IV Ion_trans PF00520.26 KOO24215.1 - 7.8e-21 74.2 23.3 1.2e-20 73.6 16.2 1.3 1 0 0 1 1 1 1 Ion transport protein Yae1_N PF09811.4 KOO24215.1 - 0.48 10.0 3.4 0.87 9.1 2.4 1.4 1 0 0 1 1 1 0 Essential protein Yae1, N terminal Rieske PF00355.21 KOO24216.1 - 4.8e-09 35.6 0.1 9.1e-09 34.7 0.1 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.1 KOO24216.1 - 2.7e-06 27.0 0.0 5.2e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain DUF1212 PF06738.7 KOO24216.1 - 0.00031 20.2 2.1 0.00038 19.9 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1212) 2OG-FeII_Oxy_2 PF13532.1 KOO24217.1 - 2.2e-20 73.3 0.0 4.9e-20 72.1 0.0 1.6 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Mg_trans_NIPA PF05653.9 KOO24217.1 - 2.2e-10 39.9 4.8 4.7e-10 38.8 3.3 1.4 1 0 0 1 1 1 1 Magnesium transporter NIPA EmrE PF13536.1 KOO24217.1 - 0.00013 22.1 19.6 0.0048 17.0 1.5 3.3 4 0 0 4 4 4 2 Multidrug resistance efflux transporter EamA PF00892.15 KOO24217.1 - 0.017 15.1 4.4 0.017 15.1 3.1 3.0 3 0 0 3 3 3 0 EamA-like transporter family Fructosamin_kin PF03881.9 KOO24218.1 - 1.5e-71 240.7 0.0 1.8e-71 240.4 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.18 KOO24218.1 - 1.6e-12 47.6 0.1 2.2e-12 47.2 0.1 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF221 PF02714.10 KOO24219.1 - 5.6e-29 101.0 0.9 9.6e-29 100.2 0.7 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF221 Anoctamin PF04547.7 KOO24219.1 - 1.1e-06 27.5 0.1 2e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 Calcium-activated chloride channel DUF4349 PF14257.1 KOO24219.1 - 2.2 7.4 8.6 9.7 5.3 1.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) Got1 PF04178.7 KOO24220.1 - 2.1e-22 79.4 11.5 6.6e-22 77.8 7.8 1.9 1 1 1 2 2 2 2 Got1/Sft2-like family Bax1-I PF01027.15 KOO24220.1 - 0.1 12.2 9.1 0.13 11.8 6.3 1.1 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 PrgI PF12666.2 KOO24220.1 - 1.9 8.6 10.6 12 6.1 0.2 2.2 2 0 0 2 2 2 0 PrgI family protein HECT PF00632.20 KOO24222.1 - 1.5e-94 316.7 0.0 2e-94 316.3 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) ABC1 PF03109.11 KOO24224.1 - 6.1e-20 71.3 0.0 2.8e-19 69.2 0.0 2.0 1 1 0 1 1 1 1 ABC1 family FAA_hydrolase PF01557.13 KOO24225.1 - 1.6e-16 60.4 0.0 1.9e-16 60.1 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FHA PF00498.21 KOO24226.1 - 3.3e-08 33.5 0.0 5.3e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 FHA domain Kinesin PF00225.18 KOO24227.1 - 1e-97 326.8 0.9 6.4e-95 317.6 0.1 2.4 2 0 0 2 2 2 2 Kinesin motor domain DUF2674 PF10879.3 KOO24227.1 - 0.11 12.2 0.7 15 5.3 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2674) X PF00739.14 KOO24228.1 - 0.11 12.3 0.0 0.17 11.8 0.0 1.1 1 0 0 1 1 1 0 Trans-activation protein X FG-GAP PF01839.18 KOO24229.1 - 8.6e-17 60.3 27.4 9.4e-05 21.9 2.2 5.5 5 0 0 5 5 5 4 FG-GAP repeat VCBS PF13517.1 KOO24229.1 - 4.6e-08 33.3 22.0 0.00038 20.7 4.1 5.1 5 2 2 7 7 7 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Zn_dep_PLPC PF00882.13 KOO24229.1 - 1e-07 31.7 0.1 1.7e-07 31.0 0.1 1.3 1 0 0 1 1 1 1 Zinc dependent phospholipase C TcdB_toxin_midN PF12256.3 KOO24229.1 - 0.29 10.5 5.1 4.8 6.5 0.0 3.5 3 1 1 4 4 4 0 Insecticide toxin TcdB middle/N-terminal region Pkinase PF00069.20 KOO24230.1 - 4.7e-49 166.8 0.0 6.8e-49 166.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO24230.1 - 2.7e-43 147.9 0.0 4.4e-43 147.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO24230.1 - 0.00056 18.9 0.0 0.0009 18.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO24230.1 - 0.02 14.6 0.0 0.041 13.6 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF221 PF02714.10 KOO24231.1 - 7e-06 25.1 0.1 1.4e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function DUF221 zf-RING_2 PF13639.1 KOO24233.1 - 8e-14 51.2 14.3 1.8e-13 50.0 9.9 1.7 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KOO24233.1 - 6.2e-10 39.0 5.7 1.4e-09 37.9 4.0 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 KOO24233.1 - 9.5e-09 34.7 9.1 1.8e-08 33.8 6.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO24233.1 - 1.1e-08 34.8 9.9 2.4e-08 33.8 6.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO24233.1 - 2e-07 30.5 9.4 2e-07 30.5 6.5 2.0 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 KOO24233.1 - 1.5e-05 24.7 5.9 3.2e-05 23.6 4.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.1 KOO24233.1 - 4.4e-05 23.1 11.5 4.4e-05 23.1 7.9 1.6 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 KOO24233.1 - 0.00014 21.5 7.4 0.00044 19.8 1.4 2.4 2 0 0 2 2 2 1 RING-type zinc-finger Tetraspannin PF00335.15 KOO24233.1 - 0.02 14.1 1.0 0.037 13.3 0.7 1.4 1 0 0 1 1 1 0 Tetraspanin family Rad50_zn_hook PF04423.9 KOO24233.1 - 0.06 12.8 1.6 0.22 11.0 0.0 2.1 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-C3HC4_4 PF15227.1 KOO24233.1 - 0.077 12.8 8.3 0.17 11.7 5.7 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.3 KOO24233.1 - 0.2 11.2 5.2 0.34 10.4 3.6 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit RINGv PF12906.2 KOO24233.1 - 1.7 8.7 11.6 0.75 9.8 6.0 2.0 2 0 0 2 2 2 0 RING-variant domain zf-P11 PF03854.9 KOO24233.1 - 8.6 5.9 12.0 1.3 8.5 3.0 2.6 1 1 1 2 2 2 0 P-11 zinc finger RAP PF08373.5 KOO24235.1 - 8.4e-15 54.3 0.0 1.6e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 RAP domain dsrm PF00035.20 KOO24235.1 - 5.5e-13 49.2 0.0 1.3e-12 48.0 0.0 1.7 1 0 0 1 1 1 1 Double-stranded RNA binding motif DND1_DSRM PF14709.1 KOO24235.1 - 7e-08 32.6 0.0 1.7e-07 31.4 0.0 1.7 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 FAST_1 PF06743.10 KOO24235.1 - 0.063 13.0 0.0 0.68 9.6 0.0 2.3 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 DUF559 PF04480.7 KOO24235.1 - 0.1 12.3 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF559) zf-met PF12874.2 KOO24235.1 - 0.32 11.2 2.4 2.9 8.2 0.0 2.9 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Peptidase_S10 PF00450.17 KOO24236.1 - 1.4e-81 274.8 0.0 1.9e-62 211.7 0.0 2.0 2 0 0 2 2 2 2 Serine carboxypeptidase RNB PF00773.14 KOO24237.1 - 8e-44 150.2 5.1 9.7e-31 107.2 0.1 2.2 1 1 1 2 2 2 2 RNB domain Pro_isomerase PF00160.16 KOO24237.1 - 1.7e-24 86.7 0.0 3.4e-24 85.8 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PIN_4 PF13638.1 KOO24237.1 - 4.2e-15 56.0 0.1 9.6e-15 54.8 0.1 1.7 1 0 0 1 1 1 1 PIN domain OB_RNB PF08206.6 KOO24237.1 - 0.00019 20.8 0.0 0.54 9.7 0.0 3.0 3 0 0 3 3 3 2 Ribonuclease B OB domain ATPgrasp_TupA PF14305.1 KOO24238.1 - 0.00098 18.4 0.0 0.0013 18.0 0.0 1.1 1 0 0 1 1 1 1 TupA-like ATPgrasp PDZ_2 PF13180.1 KOO24239.1 - 2.1e-06 27.5 0.0 5.6e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.19 KOO24239.1 - 5.1e-05 23.3 0.0 0.0001 22.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Peptidase_M57 PF12388.3 KOO24239.1 - 0.00062 19.1 0.0 0.0013 18.1 0.0 1.5 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase Peptidase_M10 PF00413.19 KOO24239.1 - 0.00099 18.8 0.4 0.36 10.5 0.2 2.6 3 0 0 3 3 3 2 Matrixin Shisa PF13908.1 KOO24239.1 - 0.0095 16.1 0.0 0.068 13.3 0.0 2.3 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator Astacin PF01400.19 KOO24239.1 - 0.7 9.2 2.4 2 7.7 1.6 1.7 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Nucleotid_trans PF03407.11 KOO24240.1 - 4e-11 43.1 0.2 5.3e-11 42.6 0.1 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase UPF0370 PF13980.1 KOO24241.1 - 0.14 11.9 0.3 0.3 10.9 0.2 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) DUF3431 PF11913.3 KOO24242.1 - 2.3e-05 23.9 0.0 0.00012 21.6 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3431) HAD_2 PF13419.1 KOO24242.1 - 0.0076 16.4 0.0 0.027 14.6 0.0 1.9 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase HEAT_2 PF13646.1 KOO24243.1 - 1.5e-66 220.6 73.7 8.6e-15 54.7 2.8 8.0 1 1 6 8 8 8 7 HEAT repeats HEAT PF02985.17 KOO24243.1 - 3.3e-61 197.9 37.4 0.00044 20.1 0.0 14.8 15 0 0 15 15 15 14 HEAT repeat HEAT_EZ PF13513.1 KOO24243.1 - 4.1e-46 154.3 66.6 3.4e-06 27.3 0.7 13.4 11 3 3 14 14 14 13 HEAT-like repeat Cnd1 PF12717.2 KOO24243.1 - 8.9e-22 77.7 1.1 0.0081 16.0 0.0 8.8 1 1 6 8 8 8 6 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.15 KOO24243.1 - 6.1e-20 71.0 21.3 0.00059 18.2 0.2 5.1 1 1 3 5 5 5 5 Adaptin N terminal region Cohesin_HEAT PF12765.2 KOO24243.1 - 2.9e-19 68.5 67.9 0.0063 16.4 0.2 14.9 15 0 0 15 15 15 9 HEAT repeat associated with sister chromatid cohesion Arm PF00514.18 KOO24243.1 - 1.5e-16 59.5 26.8 1.1 9.1 0.0 11.6 12 0 0 12 12 12 7 Armadillo/beta-catenin-like repeat CLASP_N PF12348.3 KOO24243.1 - 9.2e-08 31.7 8.6 1.7 7.9 0.0 7.6 1 1 5 7 7 7 2 CLASP N terminal Sial-lect-inser PF09264.5 KOO24243.1 - 0.00047 19.5 8.6 13 5.0 0.0 7.9 2 2 10 12 12 12 0 Vibrio cholerae sialidase, lectin insertion V-ATPase_H_C PF11698.3 KOO24243.1 - 0.0042 17.0 0.6 1.4e+02 2.4 0.0 6.5 6 1 3 9 9 9 0 V-ATPase subunit H DNA_alkylation PF08713.6 KOO24243.1 - 0.11 12.0 7.0 20 4.5 0.0 4.7 1 1 2 5 5 5 0 DNA alkylation repair enzyme VARLMGL PF14383.1 KOO24243.1 - 0.32 10.1 18.9 22 4.3 0.1 7.2 7 0 0 7 7 7 0 DUF761-associated sequence motif EF-hand_1 PF00036.27 KOO24244.1 - 1.1e-14 52.4 0.0 1.5e-06 27.0 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO24244.1 - 5e-13 47.7 0.1 3.5e-06 26.4 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO24244.1 - 1.8e-11 43.4 0.2 4.7e-08 32.5 0.0 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO24244.1 - 2.3e-11 42.4 0.1 2.1e-05 23.6 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO24244.1 - 6.4e-11 42.2 0.1 3e-10 40.0 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_4 PF12763.2 KOO24244.1 - 0.011 15.5 0.1 6.2 6.6 0.0 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Ank PF00023.25 KOO24245.1 - 5.2e-23 79.6 0.4 1.1e-10 40.7 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.2 KOO24245.1 - 5.2e-21 74.7 0.1 3.8e-18 65.6 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO24245.1 - 3.9e-12 45.1 0.1 0.00013 21.8 0.0 3.9 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.1 KOO24245.1 - 1.3e-11 44.6 0.0 8.8e-05 22.9 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO24245.1 - 1.5e-10 40.9 0.3 0.00024 21.2 0.0 4.0 1 1 3 4 4 4 2 Ankyrin repeats (many copies) OTU PF02338.14 KOO24245.1 - 2e-06 28.3 0.0 3.6e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease PDZ PF00595.19 KOO24246.1 - 2.1e-09 37.4 0.2 3.8e-05 23.7 0.0 2.5 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) Tricorn_PDZ PF14685.1 KOO24246.1 - 0.0021 17.7 0.2 0.13 12.0 0.0 2.5 2 0 0 2 2 2 1 Tricorn protease PDZ domain Gal-3-0_sulfotr PF06990.6 KOO24247.1 - 0.00017 20.3 0.0 0.00044 19.0 0.0 1.6 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase ShK PF01549.19 KOO24247.1 - 0.0019 18.5 4.1 0.0019 18.5 2.8 2.2 2 0 0 2 2 2 1 ShK domain-like CRAL_TRIO PF00650.15 KOO24248.1 - 5.3e-12 45.5 0.0 7e-12 45.1 0.0 1.3 1 1 0 1 1 1 1 CRAL/TRIO domain Chorion_S16 PF05836.7 KOO24248.1 - 0.029 14.2 0.2 5.4 6.9 0.1 2.2 2 0 0 2 2 2 0 Chorion protein S16 Choline_kinase PF01633.15 KOO24249.1 - 9.6e-13 48.1 0.0 1.8e-12 47.3 0.0 1.4 1 1 0 1 1 1 1 Choline/ethanolamine kinase CDKN3 PF05706.7 KOO24249.1 - 9e-05 21.9 0.0 0.00015 21.2 0.0 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) DSPc PF00782.15 KOO24249.1 - 0.0024 17.4 0.1 0.004 16.7 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 KOO24249.1 - 0.0065 16.7 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 KOO24249.1 - 0.011 15.1 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DUF3342 PF11822.3 KOO24250.1 - 1e-40 139.8 0.0 1.3e-40 139.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) BTB PF00651.26 KOO24250.1 - 0.00026 20.9 0.0 0.00045 20.1 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain SET PF00856.23 KOO24251.1 - 6.8e-12 45.9 0.0 7.8e-08 32.7 0.0 2.3 2 0 0 2 2 2 2 SET domain SAF PF08666.7 KOO24251.1 - 0.048 14.0 0.0 1.9 8.9 0.0 2.4 2 0 0 2 2 2 0 SAF domain TRAM_LAG1_CLN8 PF03798.11 KOO24252.1 - 1.2e-25 90.2 9.7 2e-25 89.4 6.7 1.4 1 0 0 1 1 1 1 TLC domain Aldo_ket_red PF00248.16 KOO24253.1 - 1.1e-45 155.7 0.0 1.2e-45 155.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Myb_DNA-binding PF00249.26 KOO24254.1 - 3.8e-08 33.2 0.0 7.8e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO24254.1 - 5.2e-08 32.8 0.1 7.6e-08 32.3 0.1 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain LRR_4 PF12799.2 KOO24255.1 - 3.4e-16 58.4 6.5 1.2e-06 27.9 2.2 4.0 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO24255.1 - 1.6e-12 46.9 6.3 6.6e-07 28.9 0.3 3.5 2 1 1 3 3 3 3 Leucine rich repeat RhoGAP PF00620.22 KOO24255.1 - 1.1e-11 44.5 0.0 1.9e-11 43.7 0.0 1.4 1 1 0 1 1 1 1 RhoGAP domain LRR_1 PF00560.28 KOO24255.1 - 3.4e-06 26.3 9.1 0.025 14.5 0.0 5.5 4 2 1 5 5 5 1 Leucine Rich Repeat LRR_6 PF13516.1 KOO24255.1 - 9.4e-06 25.1 1.4 4.6 7.6 0.0 5.6 6 0 0 6 6 6 1 Leucine Rich repeat LRR_7 PF13504.1 KOO24255.1 - 1e-05 24.9 4.5 0.13 12.5 0.2 6.1 5 1 1 6 6 6 1 Leucine rich repeat LRR_9 PF14580.1 KOO24255.1 - 5e-05 22.9 0.0 0.026 14.0 0.1 2.2 2 0 0 2 2 2 2 Leucine-rich repeat APH PF01636.18 KOO24256.1 - 1.2e-10 41.5 0.7 1.1e-09 38.3 0.5 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.15 KOO24256.1 - 1.8e-10 40.4 0.0 6.7e-10 38.5 0.0 1.8 1 1 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.15 KOO24256.1 - 0.03 13.9 0.0 0.044 13.3 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Snapin_Pallidin PF14712.1 KOO24257.1 - 0.27 11.5 4.1 13 6.1 0.8 2.6 1 1 1 2 2 2 0 Snapin/Pallidin HSA PF07529.8 KOO24257.1 - 0.46 10.3 3.9 4.2 7.2 0.1 3.1 3 0 0 3 3 3 0 HSA IncA PF04156.9 KOO24257.1 - 1.4 8.4 7.5 3 7.4 5.2 1.5 1 0 0 1 1 1 0 IncA protein Pox_A_type_inc PF04508.7 KOO24257.1 - 2.5 8.0 0.0 2.5 8.0 0.0 3.3 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Thioredoxin PF00085.15 KOO24258.1 - 2.9e-23 81.5 0.0 3.9e-23 81.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 KOO24258.1 - 2.7e-07 30.7 0.0 1.2e-06 28.7 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 KOO24258.1 - 3.3e-07 30.3 0.0 2.7e-05 24.1 0.0 2.2 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_7 PF13899.1 KOO24258.1 - 8.8e-05 22.4 0.0 0.00014 21.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.1 KOO24258.1 - 9.3e-05 22.0 0.0 0.00012 21.5 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin HyaE PF07449.6 KOO24258.1 - 0.00043 20.1 0.0 0.00074 19.3 0.0 1.3 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE AhpC-TSA PF00578.16 KOO24258.1 - 0.017 14.8 0.0 0.021 14.4 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA family Redoxin PF08534.5 KOO24258.1 - 0.073 12.6 0.0 0.11 11.9 0.0 1.4 1 1 0 1 1 1 0 Redoxin Thioredoxin_3 PF13192.1 KOO24258.1 - 0.15 11.9 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin domain COX5A PF02284.11 KOO24260.1 - 0.047 13.6 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Va Asp-B-Hydro_N PF05279.6 KOO24260.1 - 3.4 7.4 13.5 3.8 7.2 9.4 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region BBP1_C PF15272.1 KOO24260.1 - 6.6 6.2 10.6 17 4.9 6.7 1.8 1 1 1 2 2 2 0 Spindle pole body component BBP1, C-terminal GrpE PF01025.14 KOO24260.1 - 9.9 5.6 22.2 4 6.9 7.3 2.1 1 1 1 2 2 2 0 GrpE CC2D2AN-C2 PF15625.1 KOO24261.1 - 3.8e-18 65.5 0.0 7.1e-18 64.6 0.0 1.5 1 0 0 1 1 1 1 CC2D2A N-terminal C2 domain C2 PF00168.25 KOO24261.1 - 0.041 13.7 0.0 0.12 12.2 0.0 1.8 1 0 0 1 1 1 0 C2 domain Octopine_DH PF02317.12 KOO24262.1 - 4.1e-18 65.5 0.0 6e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain NAD_Gly3P_dh_N PF01210.18 KOO24262.1 - 2.2e-06 27.5 0.1 4.4e-06 26.5 0.0 1.5 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.11 KOO24262.1 - 0.017 14.5 0.0 0.028 13.8 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.12 KOO24262.1 - 0.042 14.2 0.0 0.11 12.9 0.0 1.7 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent EF-hand_1 PF00036.27 KOO24264.1 - 2.9e-25 85.6 1.6 6.1e-06 25.1 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO24264.1 - 1.5e-24 83.6 1.3 5.6e-05 22.6 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO24264.1 - 1.2e-23 82.9 2.2 3.1e-12 46.4 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO24264.1 - 2.2e-22 77.2 1.6 7e-06 25.1 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO24264.1 - 3.5e-17 61.7 6.5 2.7e-06 26.9 0.1 4.2 2 2 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO24264.1 - 2.8e-05 24.1 0.0 0.64 10.0 0.0 2.9 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO24264.1 - 0.00013 21.6 0.9 0.0092 15.7 0.1 2.8 2 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO24264.1 - 0.015 15.1 0.0 6 6.8 0.0 3.0 2 2 1 3 3 3 0 EF-hand domain Sigma70_r1_1 PF03979.9 KOO24264.1 - 0.058 13.3 0.0 1.6 8.7 0.0 2.2 2 0 0 2 2 2 0 Sigma-70 factor, region 1.1 DUF3203 PF11462.3 KOO24264.1 - 0.067 13.1 0.2 0.18 11.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3203) Toprim PF01751.17 KOO24264.1 - 0.067 13.1 0.3 1.9 8.5 0.2 2.3 1 1 0 1 1 1 0 Toprim domain GCN5L1 PF06320.8 KOO24265.1 - 0.095 12.5 0.1 0.095 12.5 0.1 1.9 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) Acetyltransf_1 PF00583.19 KOO24266.1 - 0.00029 20.8 0.0 0.001 19.0 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 KOO24266.1 - 0.036 14.2 0.0 0.067 13.3 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Macro PF01661.16 KOO24267.1 - 2.8e-12 46.5 0.0 4e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Macro domain Ammonium_transp PF00909.16 KOO24269.1 - 5.3e-105 351.1 30.9 6.2e-105 350.9 21.4 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family PARP PF00644.15 KOO24270.1 - 1.3e-13 50.9 0.7 1.7e-09 37.4 0.0 2.4 1 1 1 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain Ank_2 PF12796.2 KOO24271.1 - 7.1e-29 99.9 0.2 2.7e-15 56.4 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO24271.1 - 1.8e-23 81.0 1.6 1e-09 37.6 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 KOO24271.1 - 4.7e-22 77.9 8.6 3.2e-08 33.8 0.2 4.2 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO24271.1 - 2.4e-20 72.0 4.1 2.1e-10 40.5 0.3 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO24271.1 - 1.2e-13 49.8 0.2 0.00013 21.8 0.0 4.8 5 0 0 5 5 5 2 Ankyrin repeat Acetyltransf_6 PF13480.1 KOO24271.1 - 0.047 13.6 0.7 0.08 12.8 0.1 1.6 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain WD40 PF00400.27 KOO24272.1 - 6.9e-29 98.6 6.8 0.045 13.6 0.0 9.5 9 0 0 9 9 9 9 WD domain, G-beta repeat HELP PF03451.9 KOO24272.1 - 2.6e-05 23.6 0.3 0.13 11.8 0.0 2.5 2 0 0 2 2 2 2 HELP motif EF-hand_7 PF13499.1 KOO24272.1 - 0.0001 22.3 0.0 0.18 11.9 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair CENP-Q PF13094.1 KOO24272.1 - 0.077 13.0 3.0 0.22 11.5 0.3 2.3 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit CPSF_A PF03178.10 KOO24272.1 - 0.11 11.5 0.0 9.9 5.1 0.0 2.9 3 0 0 3 3 3 0 CPSF A subunit region EF-hand_1 PF00036.27 KOO24272.1 - 0.11 11.8 0.0 22 4.6 0.0 2.7 2 0 0 2 2 2 0 EF hand DUF3273 PF11677.3 KOO24273.1 - 0.04 13.1 0.1 0.04 13.1 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3273) DUF563 PF04577.9 KOO24274.1 - 2.2e-05 24.4 0.1 3.3e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Acyl-CoA_dh_N PF02771.11 KOO24275.1 - 0.15 12.6 2.6 1.1 9.9 0.1 2.4 1 1 0 2 2 2 0 Acyl-CoA dehydrogenase, N-terminal domain DUF2388 PF09498.5 KOO24275.1 - 9.5 5.9 14.9 6 6.5 1.9 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF2388) Chloroa_b-bind PF00504.16 KOO24276.1 - 1.9e-30 106.2 0.0 2.5e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein APT PF03440.9 KOO24276.1 - 0.13 12.0 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 Aerolysin/Pertussis toxin (APT) domain GST_N PF02798.15 KOO24277.1 - 6e-15 55.1 0.0 1.6e-14 53.8 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KOO24277.1 - 8.6e-11 41.5 0.0 1.4e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 KOO24277.1 - 1.6e-10 41.3 0.0 2.3e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 KOO24277.1 - 6.6e-10 38.8 0.0 1e-09 38.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 KOO24277.1 - 5.2e-08 33.0 0.0 1.1e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 KOO24277.1 - 1.4e-06 28.1 0.0 4.5e-06 26.5 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Cyclase PF04199.8 KOO24279.1 - 3e-18 66.1 0.0 4.5e-18 65.5 0.0 1.2 1 0 0 1 1 1 1 Putative cyclase HAD_2 PF13419.1 KOO24279.1 - 2.6e-08 34.2 0.0 6.3e-08 33.0 0.0 1.7 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO24279.1 - 1.2e-05 25.5 0.0 2.3e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOO24279.1 - 0.00018 21.9 0.2 0.0022 18.4 0.2 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOO24279.1 - 0.00032 20.3 0.0 0.00085 18.9 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like Glyco_hydro_63 PF03200.11 KOO24280.1 - 3.2e-132 442.0 0.0 1.3e-103 347.4 0.0 2.0 1 1 1 2 2 2 2 Mannosyl oligosaccharide glucosidase Trehalase PF01204.13 KOO24280.1 - 0.0003 19.5 0.2 0.032 12.8 0.0 2.1 2 0 0 2 2 2 2 Trehalase GDE_C PF06202.9 KOO24280.1 - 0.01 14.6 0.3 0.039 12.6 0.1 1.8 2 0 0 2 2 2 0 Amylo-alpha-1,6-glucosidase Ank_2 PF12796.2 KOO24281.1 - 1.3e-18 67.1 1.0 5.4e-10 39.4 0.0 3.2 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO24281.1 - 5.3e-13 48.7 0.9 3e-05 24.1 0.0 4.1 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO24281.1 - 2e-12 46.2 10.9 3.6e-06 26.5 0.0 5.6 6 0 0 6 6 6 3 Ankyrin repeat Ank_4 PF13637.1 KOO24281.1 - 2.9e-11 43.5 1.3 7.7e-08 32.6 0.0 3.6 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO24281.1 - 4.2e-10 38.8 2.6 0.0024 17.9 0.0 5.5 6 1 0 6 6 6 3 Ankyrin repeat DUF1793 PF08760.6 KOO24284.1 - 1.7e-40 138.6 0.1 4.4e-40 137.3 0.1 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1793) COPIIcoated_ERV PF07970.7 KOO24286.1 - 2.8e-33 115.4 1.0 3.4e-33 115.1 0.1 1.5 2 0 0 2 2 2 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 KOO24286.1 - 4e-25 87.6 0.3 4e-25 87.6 0.2 1.8 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Thioredoxin PF00085.15 KOO24286.1 - 3.7e-16 58.7 0.0 8.5e-16 57.5 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.1 KOO24286.1 - 0.00036 20.4 0.0 0.00078 19.4 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_8 PF13905.1 KOO24286.1 - 0.024 14.7 0.0 0.24 11.5 0.0 2.6 4 0 0 4 4 4 0 Thioredoxin-like Thioredoxin_2 PF13098.1 KOO24286.1 - 0.099 12.8 0.0 0.23 11.6 0.0 1.6 1 1 0 1 1 1 0 Thioredoxin-like domain Helicase_C PF00271.26 KOO24287.1 - 1.2e-14 53.8 0.0 2.4e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 KOO24287.1 - 2.7e-07 29.7 0.0 4.2e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.19 KOO24287.1 - 1.8e-06 27.5 0.8 5.3e-06 26.0 0.6 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain HDA2-3 PF11496.3 KOO24287.1 - 1e-05 24.5 0.0 2.6e-05 23.2 0.0 1.6 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 HATPase_c_3 PF13589.1 KOO24291.1 - 3.7e-11 42.8 0.0 9.5e-11 41.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cupin_8 PF13621.1 KOO24292.1 - 4.8e-38 131.0 0.0 7.8e-38 130.3 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 KOO24292.1 - 5.9e-07 29.0 0.0 1.2e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Cupin superfamily protein Siah-Interact_N PF09032.6 KOO24292.1 - 0.044 13.8 0.1 0.19 11.7 0.0 2.1 2 0 0 2 2 2 0 Siah interacting protein, N terminal DUF2360 PF10152.4 KOO24292.1 - 1.7 8.8 6.7 3.6 7.8 4.7 1.4 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) DUF1874 PF08960.5 KOO24293.1 - 0.058 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1874) ATP_bind_3 PF01171.15 KOO24294.1 - 1.2e-41 142.1 0.1 1.1e-40 139.0 0.1 2.0 1 1 0 1 1 1 1 PP-loop family Asn_synthase PF00733.16 KOO24294.1 - 0.0021 17.6 0.0 0.0037 16.7 0.0 1.4 1 0 0 1 1 1 1 Asparagine synthase TilS_C PF11734.3 KOO24294.1 - 0.016 14.3 0.7 0.044 13.0 0.1 2.1 2 0 0 2 2 2 0 TilS substrate C-terminal domain QueC PF06508.8 KOO24294.1 - 0.22 10.7 0.0 0.36 10.0 0.0 1.3 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC Ion_trans PF00520.26 KOO24295.1 - 6.7e-07 28.7 2.0 9.7e-07 28.2 0.5 1.8 2 0 0 2 2 2 1 Ion transport protein ERF PF04404.7 KOO24295.1 - 0.23 10.9 0.1 0.53 9.8 0.0 1.6 2 0 0 2 2 2 0 ERF superfamily UQ_con PF00179.21 KOO24297.1 - 2.7e-41 140.2 0.0 3.8e-41 139.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KOO24297.1 - 9.7e-05 22.1 0.0 0.00015 21.5 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 KOO24297.1 - 0.012 15.5 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 0 RWD domain ASFV_J13L PF05568.6 KOO24297.1 - 4.5 6.7 8.8 6.7 6.1 6.1 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein Acid_PPase PF12689.2 KOO24298.1 - 1e-32 113.1 0.0 1.1e-32 112.9 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase HAD_2 PF13419.1 KOO24298.1 - 0.0058 16.8 0.0 0.0074 16.5 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase DUF2608 PF11019.3 KOO24298.1 - 0.018 14.0 0.0 0.025 13.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2608) MMR_HSR1 PF01926.18 KOO24299.1 - 1.5e-14 53.9 0.0 7.2e-14 51.7 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KOO24299.1 - 0.00032 19.9 0.0 0.00088 18.5 0.0 1.6 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.11 KOO24299.1 - 0.0076 15.4 0.0 0.015 14.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Kinesin PF00225.18 KOO24301.1 - 1.2e-78 264.1 0.0 4.5e-67 226.1 0.0 2.4 1 1 1 2 2 2 2 Kinesin motor domain DEAD PF00270.24 KOO24301.1 - 0.084 12.3 0.6 13 5.2 0.0 2.5 2 0 0 2 2 2 0 DEAD/DEAH box helicase Pepsin-I3 PF06394.8 KOO24301.1 - 0.099 12.3 0.7 0.27 10.9 0.5 1.8 1 0 0 1 1 1 0 Pepsin inhibitor-3-like repeated domain Tegument_dsDNA PF12818.2 KOO24302.1 - 0.0017 17.2 0.0 0.0025 16.7 0.0 1.3 1 0 0 1 1 1 1 dsDNA viral tegument protein Ribosomal_60s PF00428.14 KOO24302.1 - 0.013 15.9 22.1 0.017 15.5 14.3 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein DREPP PF05558.7 KOO24304.1 - 0.44 10.3 10.3 2.7 7.8 7.2 1.9 1 1 0 1 1 1 0 DREPP plasma membrane polypeptide Amino_oxidase PF01593.19 KOO24306.1 - 1e-73 248.9 0.0 1.2e-73 248.7 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 KOO24306.1 - 1.8e-16 59.8 0.1 4.5e-16 58.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOO24306.1 - 2.6e-12 46.3 0.0 2e-05 23.6 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.22 KOO24306.1 - 6e-06 26.5 0.1 0.0014 19.0 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 KOO24306.1 - 0.00021 21.2 0.0 0.0017 18.2 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 KOO24306.1 - 0.00032 19.6 0.6 0.0064 15.3 0.2 2.2 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.9 KOO24306.1 - 0.0013 17.3 0.2 0.0037 15.7 0.2 1.6 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.1 KOO24306.1 - 0.0013 18.8 0.0 0.012 15.6 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 KOO24306.1 - 0.0025 16.9 0.1 0.0045 16.0 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 KOO24306.1 - 0.0038 16.3 0.2 0.0076 15.3 0.1 1.5 1 0 0 1 1 1 1 Thi4 family Trp_halogenase PF04820.9 KOO24306.1 - 0.005 15.5 0.0 0.65 8.5 0.0 2.4 2 0 0 2 2 2 1 Tryptophan halogenase FMO-like PF00743.14 KOO24306.1 - 0.01 14.0 0.1 0.018 13.2 0.1 1.3 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like FAD_oxidored PF12831.2 KOO24306.1 - 0.052 12.6 0.0 0.1 11.6 0.0 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 KOO24306.1 - 0.071 12.0 0.0 0.13 11.1 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Galactosyl_T PF01762.16 KOO24308.1 - 0.00071 19.2 0.0 0.0034 17.0 0.0 2.1 1 1 0 1 1 1 1 Galactosyltransferase WW PF00397.21 KOO24310.1 - 1e-08 34.8 8.1 1.9e-08 33.9 5.6 1.5 1 0 0 1 1 1 1 WW domain PDZ PF00595.19 KOO24310.1 - 7.2e-08 32.5 0.3 1.4e-07 31.5 0.2 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) FCP1_C PF09309.5 KOO24310.1 - 0.0009 18.6 1.6 0.0017 17.7 1.1 1.4 1 0 0 1 1 1 1 FCP1, C-terminal PDZ_2 PF13180.1 KOO24310.1 - 0.00096 18.9 0.3 0.0021 17.8 0.2 1.6 1 0 0 1 1 1 1 PDZ domain Adeno_terminal PF02459.10 KOO24312.1 - 0.12 10.4 0.1 0.14 10.2 0.1 1.0 1 0 0 1 1 1 0 Adenoviral DNA terminal protein SLX9 PF15341.1 KOO24312.1 - 1.6 9.1 10.2 0.29 11.5 3.5 1.9 1 1 1 2 2 2 0 Ribosome biogenesis protein SLX9 Topo-VIb_trans PF09239.6 KOO24313.1 - 3.1e-45 153.5 0.0 5.3e-45 152.8 0.0 1.3 1 0 0 1 1 1 1 Topoisomerase VI B subunit, transducer HATPase_c_3 PF13589.1 KOO24313.1 - 2e-10 40.4 0.3 6.4e-08 32.3 0.2 2.4 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 KOO24313.1 - 3.8e-10 39.4 0.0 8.9e-10 38.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase FbpA PF05833.6 KOO24313.1 - 0.0011 17.5 0.0 0.0025 16.4 0.0 1.5 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) PQQ PF01011.16 KOO24314.1 - 0.11 12.0 0.1 23 4.7 0.0 2.7 2 0 0 2 2 2 0 PQQ enzyme repeat Rieske PF00355.21 KOO24315.1 - 1.1e-15 56.9 0.6 2.1e-15 56.0 0.4 1.5 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.9 KOO24315.1 - 1.1e-09 38.3 0.4 1.9e-09 37.6 0.3 1.4 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region GASA PF02704.9 KOO24315.1 - 0.15 12.0 0.8 0.24 11.3 0.6 1.3 1 0 0 1 1 1 0 Gibberellin regulated protein DUF3006 PF11213.3 KOO24316.1 - 0.00032 20.3 0.0 0.00043 19.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3006) ILVD_EDD PF00920.16 KOO24317.1 - 9e-181 601.8 3.8 1e-180 601.6 2.6 1.0 1 0 0 1 1 1 1 Dehydratase family Patched PF02460.13 KOO24318.1 - 6.7e-07 27.6 21.1 0.002 16.1 13.8 2.4 2 0 0 2 2 2 2 Patched family Phage_holin PF04688.8 KOO24318.1 - 0.076 12.5 0.7 0.38 10.2 0.0 2.6 2 0 0 2 2 2 0 Phage lysis protein, holin MCRS_N PF13325.1 KOO24318.1 - 0.88 9.0 0.0 2.3 7.7 0.0 1.6 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein DUF1129 PF06570.6 KOO24318.1 - 4.4 6.5 9.1 4.6 6.4 0.0 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1129) DAO PF01266.19 KOO24319.1 - 1.4e-14 53.8 0.1 1.7e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase EF-hand_7 PF13499.1 KOO24320.1 - 1.6e-12 47.3 0.3 2.4e-12 46.8 0.2 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO24320.1 - 5.5e-12 44.0 0.7 3e-07 29.2 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO24320.1 - 4e-09 35.9 2.6 9.7e-07 28.3 0.4 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO24320.1 - 7.1e-09 34.8 0.2 9e-06 25.1 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO24320.1 - 1.5e-07 30.4 0.9 6.8e-06 25.1 0.1 2.4 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.2 KOO24320.1 - 0.006 16.2 0.1 0.52 10.0 0.1 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO24320.1 - 0.015 15.2 0.0 0.041 13.9 0.0 1.5 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF2226 PF09987.4 KOO24320.1 - 0.016 14.3 0.1 0.021 13.9 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2226) EF-hand_10 PF14788.1 KOO24320.1 - 0.032 13.8 0.1 8.4 6.1 0.0 2.3 2 0 0 2 2 2 0 EF hand DAO PF01266.19 KOO24321.1 - 6.5e-23 81.2 4.8 1e-22 80.5 3.0 1.5 1 1 1 2 2 2 1 FAD dependent oxidoreductase FAE1_CUT1_RppA PF08392.7 KOO24322.1 - 1.9e-107 358.6 0.4 5.7e-107 357.0 0.2 1.7 1 1 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein Chal_sti_synt_C PF02797.10 KOO24322.1 - 5e-11 42.7 0.0 9.6e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain ACP_syn_III_C PF08541.5 KOO24322.1 - 7.7e-09 35.4 0.0 0.00016 21.6 0.0 2.5 2 0 0 2 2 2 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.5 KOO24322.1 - 2.3e-05 23.9 0.1 6.7e-05 22.4 0.1 1.7 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Chal_sti_synt_N PF00195.14 KOO24322.1 - 0.00016 20.9 0.1 0.00032 20.0 0.1 1.5 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain Histone PF00125.19 KOO24324.1 - 1.8e-25 88.8 0.0 2.3e-25 88.4 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 KOO24324.1 - 6.1e-06 26.2 0.0 8.5e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CAP_GLY PF01302.20 KOO24325.1 - 7.6e-22 76.7 0.1 1.2e-21 76.1 0.1 1.3 1 0 0 1 1 1 1 CAP-Gly domain EF-hand_1 PF00036.27 KOO24325.1 - 1.6e-11 42.6 3.2 4.2e-05 22.5 1.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO24325.1 - 1.2e-09 38.1 0.0 2.3e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO24325.1 - 1.8e-06 27.0 0.5 0.0064 15.7 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO24325.1 - 2.8e-06 26.8 2.1 2.8e-06 26.8 1.4 2.6 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO24325.1 - 6.7e-06 25.5 0.2 0.0086 15.8 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 KOO24325.1 - 0.00062 19.4 0.1 0.0018 18.0 0.1 1.8 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO24325.1 - 0.0073 16.3 0.0 0.022 14.8 0.0 1.8 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOO24325.1 - 0.019 14.8 0.1 0.049 13.5 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain Med15 PF09606.5 KOO24325.1 - 4.3 5.4 40.3 5.9 4.9 27.9 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DAGAT PF03982.8 KOO24326.1 - 1.1e-40 139.1 0.0 1.3e-40 138.9 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Acyltransferase PF01553.16 KOO24326.1 - 0.016 14.6 0.0 0.031 13.7 0.0 1.5 1 1 0 1 1 1 0 Acyltransferase DUF2475 PF10629.4 KOO24327.1 - 0.71 10.1 14.1 0.74 10.0 0.3 4.2 3 1 1 4 4 4 0 Protein of unknown function (DUF2475) Histone PF00125.19 KOO24329.1 - 1.1e-21 76.7 0.1 1.5e-21 76.2 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 KOO24329.1 - 0.00056 19.9 0.0 0.0013 18.7 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.8 KOO24329.1 - 0.0069 16.6 0.0 0.012 15.9 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A DUF4361 PF14274.1 KOO24329.1 - 0.099 12.2 0.7 0.12 11.9 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4361) zf-RING_2 PF13639.1 KOO24330.1 - 3.5e-12 45.9 10.2 5.4e-12 45.3 7.1 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KOO24330.1 - 1.4e-08 34.7 3.2 2.4e-08 33.9 2.3 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 KOO24330.1 - 6.3e-05 22.7 0.9 0.00013 21.7 0.6 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.1 KOO24330.1 - 7.3e-05 22.7 9.7 0.00012 22.0 6.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO24330.1 - 0.0003 20.3 8.2 0.00055 19.5 5.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO24330.1 - 0.00093 18.8 7.1 0.0015 18.2 4.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 KOO24330.1 - 0.0011 18.5 7.1 0.0018 17.8 4.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.3 KOO24330.1 - 0.0074 16.2 7.9 0.077 12.9 5.5 2.2 1 1 0 1 1 1 1 FANCL C-terminal domain RINGv PF12906.2 KOO24330.1 - 1.5 8.9 8.4 2.5 8.1 5.8 1.4 1 0 0 1 1 1 0 RING-variant domain zf-RING_UBOX PF13445.1 KOO24330.1 - 3 7.6 11.1 0.58 9.9 1.5 2.3 2 0 0 2 2 2 0 RING-type zinc-finger PapD-like PF14874.1 KOO24331.1 - 0.0024 17.7 0.2 0.6 10.0 0.0 4.2 4 1 0 4 4 4 1 Flagellar-associated PapD-like WD40 PF00400.27 KOO24332.1 - 4.9e-32 108.6 10.6 3.7e-06 26.6 0.1 6.8 6 1 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.3 KOO24332.1 - 0.0011 17.1 0.5 0.17 9.9 0.0 2.3 2 0 0 2 2 2 2 Nucleoporin Nup120/160 SSB PF00436.20 KOO24332.1 - 0.034 14.0 0.0 0.064 13.1 0.0 1.3 1 0 0 1 1 1 0 Single-strand binding protein family PALP PF00291.20 KOO24333.1 - 5.7e-48 163.7 1.8 6.4e-48 163.5 1.3 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ADH_zinc_N PF00107.21 KOO24333.1 - 0.031 13.8 0.8 0.35 10.4 0.1 2.8 2 1 0 2 2 2 0 Zinc-binding dehydrogenase Phage_NinH PF06322.6 KOO24333.1 - 0.11 12.1 0.0 0.31 10.6 0.0 1.9 1 0 0 1 1 1 0 Phage NinH protein Methyltransf_18 PF12847.2 KOO24333.1 - 0.17 12.4 1.7 1.7 9.2 1.2 2.4 1 1 0 1 1 1 0 Methyltransferase domain SCO1-SenC PF02630.9 KOO24334.1 - 4.5e-48 163.1 0.0 5.7e-48 162.8 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.16 KOO24334.1 - 7.3e-09 35.3 0.0 3e-08 33.3 0.0 2.0 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.1 KOO24334.1 - 0.00016 21.7 0.0 0.00026 21.0 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.5 KOO24334.1 - 0.013 15.0 0.0 0.15 11.5 0.0 2.2 1 1 0 1 1 1 0 Redoxin IMPDH PF00478.20 KOO24335.1 - 2.1e-111 372.2 0.9 2.6e-111 371.9 0.6 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.13 KOO24335.1 - 0.0018 17.1 2.5 0.0029 16.4 1.7 1.4 1 1 0 1 1 1 1 FMN-dependent dehydrogenase PAP2_C PF14360.1 KOO24335.1 - 0.0094 16.2 0.3 0.021 15.0 0.2 1.5 1 0 0 1 1 1 1 PAP2 superfamily C-terminal PGM_PMM_III PF02880.11 KOO24335.1 - 0.086 12.8 0.4 5.5 7.0 0.0 2.4 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PcrB PF01884.12 KOO24335.1 - 0.3 10.2 2.9 0.71 9.0 0.1 2.3 2 1 0 2 2 2 0 PcrB family NHL PF01436.16 KOO24336.1 - 1.2e-21 75.4 6.8 5.1e-05 23.0 0.5 5.4 5 0 0 5 5 5 5 NHL repeat SGL PF08450.7 KOO24336.1 - 0.0051 16.2 0.0 0.074 12.4 0.0 2.3 1 1 1 2 2 2 1 SMP-30/Gluconolaconase/LRE-like region AAA_12 PF13087.1 KOO24337.1 - 9.6e-11 41.4 0.0 1.1e-10 41.2 0.0 1.0 1 0 0 1 1 1 1 AAA domain RVT_2 PF07727.9 KOO24338.1 - 3.2e-33 114.7 0.0 4.5e-33 114.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) polyprenyl_synt PF00348.12 KOO24338.1 - 0.02 13.7 0.4 0.035 12.9 0.0 1.5 2 0 0 2 2 2 0 Polyprenyl synthetase HCR PF07111.7 KOO24338.1 - 0.22 9.4 0.0 0.3 9.0 0.0 1.1 1 0 0 1 1 1 0 Alpha helical coiled-coil rod protein (HCR) PARP PF00644.15 KOO24339.1 - 0.00036 20.0 0.0 0.00084 18.8 0.0 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain AAA_22 PF13401.1 KOO24340.1 - 0.12 12.5 1.0 0.37 10.9 0.7 1.8 1 1 0 1 1 1 0 AAA domain zf-MYND PF01753.13 KOO24343.1 - 1.1e-09 38.0 11.5 4.1e-09 36.1 8.0 2.1 1 1 0 1 1 1 1 MYND finger DUF4191 PF13829.1 KOO24343.1 - 0.0083 15.2 0.1 0.015 14.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4191) Peptidase_C97 PF05903.9 KOO24344.1 - 1.4e-32 112.5 0.0 2e-32 112.0 0.0 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain PUL PF08324.6 KOO24344.1 - 7.5e-07 28.2 0.0 1e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 PUL domain Abi PF02517.11 KOO24345.1 - 1.9e-15 56.7 7.4 1.9e-15 56.7 5.1 1.9 2 0 0 2 2 2 1 CAAX protease self-immunity p450 PF00067.17 KOO24347.1 - 1.2e-12 47.1 0.0 1.6e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 LRR_6 PF13516.1 KOO24348.1 - 3.3e-08 32.7 0.0 0.0028 17.5 0.0 3.2 3 0 0 3 3 3 2 Leucine Rich repeat LRR_4 PF12799.2 KOO24348.1 - 3.4e-05 23.3 0.1 0.15 11.7 0.0 2.3 2 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO24348.1 - 0.0026 17.6 0.3 4.7 7.8 0.0 2.8 3 0 0 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 KOO24348.1 - 0.011 15.6 0.0 4.5 7.6 0.0 2.4 2 1 0 2 2 2 0 Leucine Rich Repeat LRR_8 PF13855.1 KOO24348.1 - 0.039 13.7 0.0 10 5.9 0.0 2.5 3 0 0 3 3 3 0 Leucine rich repeat RRM_1 PF00076.17 KOO24349.1 - 6.9e-06 25.6 0.0 1e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO24349.1 - 0.008 15.9 0.0 0.013 15.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO24349.1 - 0.012 15.5 0.0 0.016 15.1 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRP7 PF12923.2 KOO24350.1 - 0.17 11.8 8.1 0.4 10.7 1.3 3.2 3 0 0 3 3 3 0 Ribosomal RNA-processing protein 7 (RRP7) Abhydrolase_2 PF02230.11 KOO24351.1 - 1.1e-16 61.0 0.0 3.2e-16 59.4 0.0 1.7 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 KOO24351.1 - 6.3e-08 32.4 0.0 1.2e-07 31.5 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO24351.1 - 4.7e-07 29.9 0.1 0.00098 19.0 0.0 2.6 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 KOO24351.1 - 0.017 14.7 0.0 0.026 14.0 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold zf-DHHC PF01529.15 KOO24353.1 - 1.2e-21 76.9 2.4 2.7e-21 75.7 0.2 2.4 1 1 0 1 1 1 1 DHHC palmitoyltransferase Helitron_like_N PF14214.1 KOO24354.1 - 0.0033 17.1 0.0 0.018 14.8 0.0 2.3 2 1 0 2 2 2 1 Helitron helicase-like domain at N-terminus CLP_protease PF00574.18 KOO24355.1 - 1.7e-53 181.0 0.0 2e-53 180.7 0.0 1.0 1 0 0 1 1 1 1 Clp protease Tom7 PF08038.7 KOO24356.1 - 0.0002 20.7 0.2 0.00026 20.3 0.1 1.2 1 0 0 1 1 1 1 TOM7 family Bax1-I PF01027.15 KOO24357.1 - 8.6e-33 113.6 39.3 8.6e-33 113.6 27.2 1.7 2 0 0 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 Mito_fiss_reg PF05308.6 KOO24357.1 - 1.4 8.2 3.7 1.9 7.7 2.6 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator Metallophos PF00149.23 KOO24358.1 - 1.5e-41 141.9 0.1 2e-41 141.6 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase FA_desaturase PF00487.19 KOO24360.1 - 9.7e-21 74.3 11.0 9.7e-21 74.3 7.6 1.5 1 1 1 2 2 2 1 Fatty acid desaturase Nucleotid_trans PF03407.11 KOO24361.1 - 3.5e-37 128.2 0.0 7.8e-37 127.1 0.0 1.5 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Glyco_hydro_47 PF01532.15 KOO24362.1 - 2.4e-26 92.4 0.0 5.2e-25 88.0 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 Beta-Casp PF10996.3 KOO24364.1 - 1.9e-27 95.7 0.0 7.6e-27 93.7 0.0 2.1 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B PF00753.22 KOO24364.1 - 2e-15 56.9 0.5 6.2e-15 55.3 0.4 1.9 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily EF-hand_7 PF13499.1 KOO24364.1 - 3.8e-12 46.1 1.2 7e-12 45.3 0.8 1.5 1 0 0 1 1 1 1 EF-hand domain pair RMMBL PF07521.7 KOO24364.1 - 8.7e-12 44.6 0.0 3.8e-11 42.6 0.0 2.1 2 0 0 2 2 2 1 RNA-metabolising metallo-beta-lactamase EF-hand_8 PF13833.1 KOO24364.1 - 1.7e-11 43.5 4.8 1.4e-08 34.1 0.4 3.3 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO24364.1 - 2.1e-10 39.1 6.4 9.4e-05 21.4 0.7 3.0 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO24364.1 - 1.7e-09 36.7 3.5 0.00012 21.6 0.1 3.3 4 0 0 4 4 3 2 EF-hand domain Lactamase_B_2 PF12706.2 KOO24364.1 - 7.3e-08 32.1 0.2 1.8e-07 30.9 0.1 1.8 2 0 0 2 2 2 1 Beta-lactamase superfamily domain EF-hand_5 PF13202.1 KOO24364.1 - 1.9e-06 26.9 8.3 0.00073 18.7 0.3 3.1 3 0 0 3 3 3 2 EF hand Lactamase_B_3 PF13483.1 KOO24364.1 - 0.0022 17.7 0.1 0.014 15.0 0.0 2.1 2 0 0 2 2 2 1 Beta-lactamase superfamily domain EF-hand_4 PF12763.2 KOO24364.1 - 0.019 14.6 1.5 3.9 7.2 0.1 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Ribosomal_L11_N PF03946.9 KOO24364.1 - 0.11 11.9 0.0 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L11, N-terminal domain RR_TM4-6 PF06459.7 KOO24364.1 - 0.21 11.4 0.6 0.38 10.6 0.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pkinase PF00069.20 KOO24366.1 - 2.6e-31 108.7 0.0 5.9e-31 107.5 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO24366.1 - 8.7e-29 100.3 0.0 2e-17 63.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 KOO24366.1 - 5.8e-05 22.1 0.0 7.9e-05 21.7 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO24366.1 - 0.0035 17.1 0.1 0.014 15.0 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 KOO24366.1 - 0.019 14.0 0.0 0.027 13.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DnaJ PF00226.26 KOO24367.1 - 3.5e-17 61.8 0.9 6.1e-17 61.1 0.6 1.4 1 0 0 1 1 1 1 DnaJ domain FHA PF00498.21 KOO24367.1 - 1.8e-08 34.3 0.0 3.2e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 FHA domain ShK PF01549.19 KOO24367.1 - 4.7e-08 33.2 6.8 9.4e-08 32.2 4.7 1.4 1 0 0 1 1 1 1 ShK domain-like TFIID_20kDa PF03847.8 KOO24368.1 - 1.3e-19 70.2 2.2 1.7e-19 69.8 0.2 2.3 2 0 0 2 2 2 1 Transcription initiation factor TFIID subunit A Histone PF00125.19 KOO24368.1 - 2.3e-05 24.3 0.1 7e-05 22.8 0.1 1.8 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 KOO24368.1 - 4.3e-05 23.4 0.2 0.00011 22.1 0.2 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF3671 PF12420.3 KOO24368.1 - 0.21 11.5 2.1 4.9 7.1 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function Prenyltrans PF00432.16 KOO24370.1 - 4.6e-11 42.0 9.4 1.3e-09 37.4 0.1 3.6 4 0 0 4 4 4 2 Prenyltransferase and squalene oxidase repeat Prenyltrans_1 PF13243.1 KOO24370.1 - 1.2e-10 41.3 0.0 1.9e-05 24.6 0.0 3.5 2 1 1 3 3 3 2 Prenyltransferase-like Prenyltrans_2 PF13249.1 KOO24370.1 - 9.3e-07 29.2 0.1 2.1e-06 28.1 0.1 1.6 1 0 0 1 1 1 1 Prenyltransferase-like EF-hand_1 PF00036.27 KOO24371.1 - 9.6e-23 77.7 7.3 1.4e-05 24.0 0.0 5.0 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.1 KOO24371.1 - 2.7e-19 69.0 2.5 2e-09 37.4 0.2 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO24371.1 - 9.3e-19 66.7 5.6 0.0026 17.3 0.0 4.8 5 0 0 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO24371.1 - 5.6e-17 60.2 10.6 7.2e-05 21.9 0.2 5.2 5 1 0 5 5 5 4 EF hand EF-hand_6 PF13405.1 KOO24371.1 - 6.6e-17 59.8 7.6 0.0015 18.2 0.1 5.3 6 0 0 6 6 6 4 EF-hand domain SHOCT PF09851.4 KOO24371.1 - 1.7e-05 24.1 3.2 0.00012 21.3 0.2 3.2 3 0 0 3 3 3 1 Short C-terminal domain SPARC_Ca_bdg PF10591.4 KOO24371.1 - 0.0018 18.2 0.3 0.38 10.8 0.1 2.6 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO24371.1 - 0.43 10.3 1.3 14 5.5 0.0 3.2 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO24371.1 - 3.6 7.3 6.6 56 3.5 0.0 3.9 4 0 0 4 4 4 0 EF hand Helicase_C PF00271.26 KOO24372.1 - 2.2e-14 53.0 0.0 5.8e-14 51.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 KOO24372.1 - 1.9e-06 26.9 0.0 3.5e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain HDA2-3 PF11496.3 KOO24372.1 - 3.9e-05 22.6 0.0 0.03 13.1 0.0 2.3 2 1 0 2 2 2 2 Class II histone deacetylase complex subunits 2 and 3 CRAL_TRIO PF00650.15 KOO24373.1 - 1.6e-12 47.1 0.0 2.4e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain DUF3053 PF11254.3 KOO24373.1 - 0.13 11.5 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3053) COesterase PF00135.23 KOO24374.1 - 1.2e-82 278.4 0.0 1.3e-82 278.2 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 KOO24374.1 - 9.9e-07 28.5 0.0 4.5e-06 26.3 0.0 1.9 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 KOO24374.1 - 0.016 14.9 0.4 0.026 14.2 0.3 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family MCD PF05292.6 KOO24375.1 - 1.2e-68 231.4 0.0 5.8e-68 229.1 0.0 2.1 1 1 0 1 1 1 1 Malonyl-CoA decarboxylase (MCD) Melibiase PF02065.13 KOO24377.1 - 3.3e-17 62.2 0.6 1.5e-14 53.5 0.0 2.4 2 1 0 2 2 2 2 Melibiase Glyco_hydro_97 PF10566.4 KOO24377.1 - 0.00013 21.1 0.0 0.00019 20.6 0.0 1.2 1 0 0 1 1 1 1 Glycoside hydrolase 97 Glyco_hydro_38 PF01074.17 KOO24377.1 - 0.14 11.4 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 N-terminal domain Maf PF02545.9 KOO24378.1 - 1.1e-28 99.6 0.0 1.7e-28 99.0 0.0 1.2 1 0 0 1 1 1 1 Maf-like protein Acetyltransf_1 PF00583.19 KOO24378.1 - 1.9e-07 30.9 0.0 3.4e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 KOO24378.1 - 3.4e-05 23.9 0.1 9.2e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 KOO24378.1 - 0.00023 21.0 0.0 0.0013 18.6 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 KOO24378.1 - 0.0011 19.1 0.0 0.0018 18.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 KOO24378.1 - 0.056 13.6 0.0 0.18 11.9 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain CN_hydrolase PF00795.17 KOO24379.1 - 9.3e-12 44.6 0.0 2.4e-11 43.3 0.0 1.7 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase zf-RING_2 PF13639.1 KOO24379.1 - 9e-07 28.6 6.5 1.3e-06 28.1 3.6 2.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 KOO24379.1 - 5.3e-05 23.1 4.1 0.00014 21.7 2.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO24379.1 - 0.00011 21.8 3.5 0.00052 19.6 2.6 2.0 1 1 1 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO24379.1 - 0.00035 20.1 2.7 0.00081 19.0 1.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO24379.1 - 0.00061 19.4 3.0 0.0014 18.2 2.1 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 KOO24379.1 - 0.22 11.4 3.9 1.2 9.0 2.7 2.2 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING WD40 PF00400.27 KOO24380.1 - 2e-26 90.8 14.7 0.0019 18.0 0.0 10.0 10 0 0 10 10 10 7 WD domain, G-beta repeat EF-hand_8 PF13833.1 KOO24380.1 - 0.003 17.1 0.0 0.091 12.3 0.0 3.0 2 0 0 2 2 2 1 EF-hand domain pair eIF2A PF08662.6 KOO24380.1 - 0.0097 15.6 0.0 0.61 9.7 0.0 2.5 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A EF-hand_6 PF13405.1 KOO24380.1 - 0.017 14.9 0.0 0.41 10.6 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain EF-hand_7 PF13499.1 KOO24380.1 - 0.078 13.1 0.1 1.6 8.8 0.0 2.7 3 0 0 3 3 3 0 EF-hand domain pair EF-hand_1 PF00036.27 KOO24380.1 - 0.11 11.8 0.0 2.5 7.5 0.0 3.1 3 0 0 3 3 3 0 EF hand UQ_con PF00179.21 KOO24381.1 - 8.6e-09 34.9 0.0 3.7e-08 32.8 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme HEAT PF02985.17 KOO24381.1 - 0.0087 16.0 1.1 1.8 8.8 0.0 4.0 3 0 0 3 3 3 1 HEAT repeat Mito_fiss_reg PF05308.6 KOO24381.1 - 0.018 14.3 0.1 0.031 13.6 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator Prok-E2_B PF14461.1 KOO24381.1 - 0.024 14.3 0.1 0.048 13.4 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.17 KOO24381.1 - 0.038 13.8 0.0 0.068 13.0 0.0 1.4 1 0 0 1 1 1 0 RWD domain Cohesin_HEAT PF12765.2 KOO24381.1 - 0.051 13.5 0.0 0.14 12.1 0.0 1.8 1 0 0 1 1 1 0 HEAT repeat associated with sister chromatid cohesion Adaptin_N PF01602.15 KOO24381.1 - 0.087 11.1 0.0 0.14 10.4 0.0 1.3 1 0 0 1 1 1 0 Adaptin N terminal region TCR PF03638.10 KOO24382.1 - 3.4e-27 94.0 54.9 6.3e-15 54.7 15.3 2.2 2 0 0 2 2 2 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain Metallothio PF00131.15 KOO24382.1 - 3.7 7.4 38.3 2.3 8.1 11.3 2.3 2 0 0 2 2 2 0 Metallothionein Myb_DNA-binding PF00249.26 KOO24383.1 - 1.7e-10 40.7 0.1 3.9e-10 39.6 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO24383.1 - 7.4e-08 32.3 0.5 7.4e-08 32.3 0.3 1.6 2 0 0 2 2 2 1 Myb-like DNA-binding domain Acyltransferase PF01553.16 KOO24384.1 - 5.7e-22 77.5 0.0 1.3e-21 76.3 0.0 1.7 1 0 0 1 1 1 1 Acyltransferase PAH PF02671.16 KOO24386.1 - 1.1e-41 140.1 13.3 2.6e-22 78.1 1.1 3.5 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.7 KOO24386.1 - 7e-31 105.9 0.0 1.5e-30 104.8 0.0 1.6 1 0 0 1 1 1 1 Sin3 family co-repressor PhyH PF05721.8 KOO24388.1 - 0.00054 20.0 0.0 1.3 8.9 0.0 2.2 2 0 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) Cupin_2 PF07883.6 KOO24388.1 - 0.067 12.7 0.0 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 Cupin domain EF-hand_6 PF13405.1 KOO24389.1 - 2.7e-06 26.7 0.1 9.8e-05 21.9 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 KOO24389.1 - 8e-05 21.6 0.1 0.00028 19.9 0.0 1.9 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.1 KOO24389.1 - 0.00049 19.3 0.6 0.0022 17.2 0.2 2.1 2 0 0 2 2 2 1 EF hand LRR_6 PF13516.1 KOO24389.1 - 0.0026 17.6 0.0 0.76 10.0 0.0 3.2 3 0 0 3 3 3 1 Leucine Rich repeat EF-hand_7 PF13499.1 KOO24389.1 - 0.0042 17.1 0.1 0.017 15.2 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO24389.1 - 0.0078 15.8 0.0 0.076 12.6 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair HPP PF04982.8 KOO24389.1 - 0.0088 15.8 8.5 0.026 14.3 5.9 1.8 1 0 0 1 1 1 1 HPP family EF-hand_6 PF13405.1 KOO24391.1 - 0.0065 16.2 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.27 KOO24391.1 - 0.024 13.9 0.0 0.041 13.2 0.0 1.4 1 0 0 1 1 1 0 EF hand EF-hand_5 PF13202.1 KOO24391.1 - 0.11 11.8 0.1 0.26 10.7 0.1 1.5 1 0 0 1 1 1 0 EF hand SNARE_assoc PF09335.6 KOO24394.1 - 6.1e-17 61.9 4.6 6.1e-17 61.9 3.2 2.2 1 1 0 2 2 2 1 SNARE associated Golgi protein Bac_rhamnosid_N PF08531.5 KOO24394.1 - 0.054 13.0 0.0 0.091 12.2 0.0 1.3 1 0 0 1 1 1 0 Alpha-L-rhamnosidase N-terminal domain Esterase_phd PF10503.4 KOO24395.1 - 0.0015 17.8 0.0 0.21 10.7 0.0 2.6 2 1 0 2 2 2 2 Esterase PHB depolymerase Abhydrolase_5 PF12695.2 KOO24395.1 - 0.029 14.1 0.0 0.049 13.3 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 KOO24395.1 - 0.074 12.2 0.1 0.4 9.8 0.0 2.0 2 0 0 2 2 2 0 Prolyl oligopeptidase family Laminin_G_3 PF13385.1 KOO24396.1 - 2.3e-22 79.9 0.1 3.5e-22 79.3 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.19 KOO24396.1 - 1.1e-05 25.4 0.0 1.7e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.18 KOO24396.1 - 0.03 14.3 0.0 0.049 13.6 0.0 1.3 1 0 0 1 1 1 0 Laminin G domain DUF1152 PF06626.7 KOO24396.1 - 0.11 11.5 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1152) zf-HC5HC2H_2 PF13832.1 KOO24397.1 - 0.091 12.7 0.9 11 6.0 0.1 2.9 2 1 1 3 3 3 0 PHD-zinc-finger like domain Ank_2 PF12796.2 KOO24398.1 - 7.6e-09 35.8 0.3 1.5e-08 34.8 0.2 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO24398.1 - 1.6e-07 31.3 0.4 1.1e-06 28.6 0.2 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.25 KOO24398.1 - 1.8e-07 30.5 0.3 6.7e-07 28.8 0.2 2.1 1 0 0 1 1 1 1 Ankyrin repeat Ank_4 PF13637.1 KOO24398.1 - 3.9e-06 27.2 0.0 1.2e-05 25.6 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO24398.1 - 1.8e-05 24.5 0.2 0.00011 22.0 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat EmrE PF13536.1 KOO24399.1 - 0.011 15.9 6.7 0.33 11.1 0.9 2.5 2 0 0 2 2 2 0 Multidrug resistance efflux transporter Guanylate_cyc PF00211.15 KOO24400.1 - 6.7e-19 67.9 0.1 7.2e-19 67.8 0.0 1.0 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Arginosuc_synth PF00764.14 KOO24400.1 - 0.0081 15.2 0.0 0.0092 15.0 0.0 1.1 1 0 0 1 1 1 1 Arginosuccinate synthase DUF374 PF04028.8 KOO24401.1 - 3.7 6.8 6.3 6.8 6.0 0.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF374) NUP PF06516.6 KOO24402.1 - 0.045 12.5 0.7 0.05 12.4 0.5 1.0 1 0 0 1 1 1 0 Purine nucleoside permease (NUP) LZ_Tnp_IS66 PF13007.2 KOO24402.1 - 1.8 9.2 6.7 12 6.6 1.3 2.3 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain Abhydrolase_4 PF08386.5 KOO24403.1 - 3.9e-11 42.7 0.0 9.8e-11 41.4 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_6 PF12697.2 KOO24403.1 - 2.4e-06 27.5 2.6 6.7e-06 26.1 0.4 2.4 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO24403.1 - 3.4e-05 23.5 0.0 0.0001 21.9 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Ion_trans PF00520.26 KOO24404.1 - 7.6e-14 51.4 8.6 2e-13 50.0 6.0 1.7 1 1 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO24404.1 - 1.3e-09 37.6 6.3 1.3e-09 37.6 4.4 2.8 2 2 2 4 4 4 1 Ion channel cNMP_binding PF00027.24 KOO24404.1 - 4.4e-05 23.2 0.0 9.6e-05 22.1 0.0 1.7 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_N PF08412.5 KOO24404.1 - 0.0065 15.7 0.6 0.021 14.1 0.0 2.1 2 0 0 2 2 2 1 Ion transport protein N-terminal EF-hand_1 PF00036.27 KOO24405.1 - 9.7e-65 209.0 39.5 1.8e-06 26.8 0.0 12.5 12 0 0 12 12 12 12 EF hand EF-hand_6 PF13405.1 KOO24405.1 - 1.5e-61 198.7 30.5 5.6e-06 25.7 0.0 12.5 12 0 0 12 12 12 12 EF-hand domain EF-hand_7 PF13499.1 KOO24405.1 - 1.6e-55 185.1 32.3 2e-11 43.8 0.1 6.6 6 0 0 6 6 6 6 EF-hand domain pair EF-hand_8 PF13833.1 KOO24405.1 - 5.5e-46 153.9 35.2 1.2e-11 43.9 0.0 9.2 8 1 1 9 9 9 9 EF-hand domain pair EF-hand_5 PF13202.1 KOO24405.1 - 3.3e-43 143.1 36.4 0.00068 18.8 0.3 12.5 12 0 0 12 12 12 10 EF hand Isochorismatase PF00857.15 KOO24405.1 - 3.3e-19 69.4 0.2 6.2e-17 62.0 0.1 3.3 2 0 0 2 2 2 1 Isochorismatase family SPARC_Ca_bdg PF10591.4 KOO24405.1 - 0.00075 19.5 12.6 3.7 7.6 0.0 6.8 5 2 2 7 7 7 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO24405.1 - 0.0017 18.0 18.0 0.31 10.7 0.2 6.5 6 2 1 8 8 8 2 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.1 KOO24406.1 - 8.3e-53 176.4 20.8 4.5e-14 52.3 0.8 4.2 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO24406.1 - 5e-45 147.3 36.3 3.7e-06 26.3 0.3 8.3 8 0 0 8 8 8 8 EF-hand domain EF-hand_1 PF00036.27 KOO24406.1 - 8.2e-45 146.7 43.4 7e-06 24.9 0.4 8.5 8 0 0 8 8 8 8 EF hand EF-hand_5 PF13202.1 KOO24406.1 - 1.7e-40 134.5 46.2 7.3e-06 25.0 0.4 8.6 8 0 0 8 8 8 8 EF hand EF-hand_8 PF13833.1 KOO24406.1 - 8.1e-26 89.4 33.8 9.9e-07 28.2 0.8 8.3 7 1 1 8 8 8 7 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO24406.1 - 1.1e-07 31.8 3.4 2.2 8.3 0.3 6.1 3 3 2 5 5 5 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOO24406.1 - 4.8e-05 23.1 0.1 10 6.1 0.0 5.9 6 2 2 8 8 8 0 EF-hand domain TcdB_toxin_midN PF12256.3 KOO24406.1 - 0.0029 17.0 1.6 26 4.2 0.0 5.4 6 1 1 7 7 7 0 Insecticide toxin TcdB middle/N-terminal region Caleosin PF05042.8 KOO24406.1 - 0.0029 17.1 4.0 18 4.8 0.0 5.2 4 3 1 5 5 5 0 Caleosin related protein Barwin PF00967.12 KOO24406.1 - 0.0045 16.6 13.7 3.4 7.3 0.0 6.2 6 2 1 8 8 8 3 Barwin family PCP PF02429.10 KOO24406.1 - 0.0088 16.1 3.7 3.2 7.8 0.1 3.2 3 0 0 3 3 3 1 Peridinin-chlorophyll A binding protein RE_HaeIII PF09556.5 KOO24406.1 - 0.013 14.4 0.2 9.8 4.9 0.0 3.2 3 0 0 3 3 3 0 HaeIII restriction endonuclease VCBS PF13517.1 KOO24406.1 - 0.051 13.9 27.6 1.1 9.6 0.0 6.5 7 1 1 8 8 8 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella HTH_38 PF13936.1 KOO24406.1 - 0.11 12.1 0.1 23 4.6 0.0 3.5 3 0 0 3 3 3 0 Helix-turn-helix domain EF-hand_4 PF12763.2 KOO24406.1 - 1.9 8.2 15.2 12 5.7 0.0 5.3 8 0 0 8 8 7 0 Cytoskeletal-regulatory complex EF hand VWA_2 PF13519.1 KOO24408.1 - 0.025 14.7 0.0 0.046 13.8 0.0 1.4 1 0 0 1 1 1 0 von Willebrand factor type A domain Fringe PF02434.11 KOO24408.1 - 0.056 12.6 0.0 0.22 10.6 0.0 1.8 2 0 0 2 2 2 0 Fringe-like BT1 PF03092.11 KOO24410.1 - 2.4e-10 39.7 14.7 2.8e-07 29.5 0.4 2.5 2 1 0 2 2 2 2 BT1 family DUF2207 PF09972.4 KOO24410.1 - 0.17 10.4 0.8 0.28 9.7 0.1 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2636 PF11120.3 KOO24410.1 - 1 8.8 7.3 0.74 9.3 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2636) Nodulin-like PF06813.8 KOO24413.1 - 1e-07 31.4 2.8 0.0059 15.8 0.1 2.6 1 1 1 2 2 2 2 Nodulin-like C2 PF00168.25 KOO24414.1 - 8.3e-12 44.7 0.0 1.6e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 C2 domain PSII_BNR PF14870.1 KOO24415.1 - 4.6e-115 383.7 0.2 5.6e-115 383.4 0.1 1.1 1 0 0 1 1 1 1 Photosynthesis system II assembly factor YCF48 BNR PF02012.15 KOO24415.1 - 7.9e-07 27.9 6.9 2 8.5 0.1 5.0 4 0 0 4 4 4 4 BNR/Asp-box repeat Got1 PF04178.7 KOO24416.1 - 0.066 13.3 5.4 0.11 12.5 3.7 1.4 1 0 0 1 1 1 0 Got1/Sft2-like family DHQ_synthase PF01761.15 KOO24417.1 - 9.8e-62 208.2 0.0 1.5e-61 207.6 0.0 1.2 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.1 KOO24417.1 - 4e-07 29.5 0.0 1.1e-06 28.1 0.0 1.7 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase TPR_11 PF13414.1 KOO24419.1 - 6.8e-18 64.0 3.3 5.4e-09 35.5 0.1 3.6 2 1 1 3 3 3 3 TPR repeat TPR_2 PF07719.12 KOO24419.1 - 3.4e-16 57.7 0.7 0.00047 19.8 0.0 5.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.23 KOO24419.1 - 5.6e-15 54.2 0.0 0.00088 18.7 0.0 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOO24419.1 - 2.4e-14 53.0 1.1 2.6e-06 27.2 0.1 3.9 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO24419.1 - 5.7e-09 35.1 0.4 0.043 13.6 0.0 4.5 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO24419.1 - 2.2e-08 33.2 0.4 0.16 11.8 0.0 5.0 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO24419.1 - 9e-08 32.3 1.2 0.0046 17.2 0.2 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO24419.1 - 2.9e-06 27.4 17.0 0.37 11.5 1.0 5.4 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOO24419.1 - 5.1e-05 23.4 6.0 0.29 11.7 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO24419.1 - 0.0012 19.4 18.0 0.019 15.6 1.6 4.7 4 2 1 5 5 4 2 Tetratricopeptide repeat Apc3 PF12895.2 KOO24419.1 - 0.0053 16.8 0.1 0.35 11.0 0.1 2.6 1 1 2 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.1 KOO24419.1 - 0.006 16.4 7.3 0.82 9.6 0.1 4.2 4 1 0 4 4 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO24419.1 - 0.025 14.7 0.0 7.3 7.0 0.0 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat CTDII PF01556.13 KOO24421.1 - 9.9e-33 111.8 0.4 3.8e-22 77.9 0.0 3.3 3 0 0 3 3 3 3 DnaJ C terminal domain DnaJ PF00226.26 KOO24421.1 - 3.7e-25 87.4 0.2 5.5e-25 86.8 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 KOO24421.1 - 2.8e-14 52.8 17.0 4.7e-14 52.1 11.8 1.4 1 0 0 1 1 1 1 DnaJ central domain DUF2586 PF10758.4 KOO24421.1 - 0.11 11.5 0.0 0.15 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2586) DZR PF12773.2 KOO24421.1 - 0.19 11.5 10.0 0.98 9.2 6.9 2.0 1 1 0 1 1 1 0 Double zinc ribbon HypA PF01155.14 KOO24421.1 - 3.4 7.3 8.5 1.1 8.9 0.8 2.3 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family NHL PF01436.16 KOO24422.1 - 2e-31 106.3 12.7 1.2e-06 28.1 0.0 6.1 7 0 0 7 7 7 5 NHL repeat SGL PF08450.7 KOO24422.1 - 2.3e-05 23.9 0.0 0.029 13.7 0.0 2.8 3 0 0 3 3 3 2 SMP-30/Gluconolaconase/LRE-like region PQQ_3 PF13570.1 KOO24422.1 - 3.4e-05 23.9 2.7 2.8 8.3 0.0 5.1 4 0 0 4 4 4 2 PQQ-like domain Lactonase PF10282.4 KOO24422.1 - 0.00046 19.3 0.0 0.00092 18.3 0.0 1.6 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller F-box-like PF12937.2 KOO24422.1 - 0.063 13.0 0.0 0.17 11.6 0.0 1.7 1 0 0 1 1 1 0 F-box-like Ank_2 PF12796.2 KOO24424.1 - 7.7e-15 55.0 0.1 5.6e-14 52.2 0.1 2.3 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO24424.1 - 1.9e-13 49.4 1.3 6.7e-07 28.8 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat EF-hand_1 PF00036.27 KOO24424.1 - 1.2e-12 46.1 0.4 4.6e-05 22.4 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO24424.1 - 2.7e-11 42.9 0.3 1.8e-10 40.2 0.1 2.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO24424.1 - 7e-10 37.7 1.2 1.9e-05 23.7 0.2 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO24424.1 - 8.1e-10 38.7 0.0 2.1e-09 37.3 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair Ank_4 PF13637.1 KOO24424.1 - 1.3e-09 38.3 0.3 0.00022 21.6 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeats (many copies) EF-hand_6 PF13405.1 KOO24424.1 - 2e-09 36.5 0.1 1.4e-05 24.5 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain Ank_3 PF13606.1 KOO24424.1 - 3.9e-08 32.7 0.2 0.0035 17.4 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 KOO24424.1 - 1.1e-06 28.6 3.1 0.0022 18.1 0.0 3.1 2 1 1 3 3 2 2 Ankyrin repeats (many copies) ART PF01129.13 KOO24424.1 - 0.00014 21.0 0.0 0.00025 20.2 0.0 1.3 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.9 KOO24424.1 - 0.00056 19.1 0.0 0.0018 17.5 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosyltransferase exoenzyme EF-hand_4 PF12763.2 KOO24424.1 - 0.019 14.6 0.0 1.1 8.9 0.0 2.6 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand DUF2431 PF10354.4 KOO24425.1 - 2.2e-45 154.5 0.0 2.9e-45 154.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) Methyltransf_26 PF13659.1 KOO24425.1 - 0.0033 17.4 0.5 0.0063 16.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 KOO24425.1 - 0.026 13.8 0.0 0.045 13.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain TPR_10 PF13374.1 KOO24426.1 - 1.2e-39 133.0 12.9 9.8e-13 47.5 0.4 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_12 PF13424.1 KOO24426.1 - 1.9e-32 111.0 6.0 1.6e-15 56.8 0.2 3.0 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO24426.1 - 1.8e-10 39.8 6.0 0.0027 17.4 0.1 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO24426.1 - 4.3e-10 38.6 7.0 0.05 13.4 0.1 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.23 KOO24426.1 - 5.8e-10 38.3 1.1 0.02 14.4 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO24426.1 - 1.8e-08 33.8 2.4 0.0012 18.4 0.2 2.8 1 1 0 2 2 2 2 TPR repeat TPR_8 PF13181.1 KOO24426.1 - 8.1e-07 28.3 0.1 0.099 12.4 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO24426.1 - 9.2e-06 25.4 0.0 2 8.8 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO24426.1 - 3.2e-05 24.4 14.3 0.00033 21.2 0.6 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_4 PF07721.9 KOO24426.1 - 7.4e-05 22.8 7.9 0.064 13.7 0.0 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat Pentapeptide_4 PF13599.1 KOO24426.1 - 0.00024 20.8 0.0 0.0012 18.5 0.0 1.9 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) TPR_19 PF14559.1 KOO24426.1 - 0.0068 16.7 7.8 0.038 14.3 0.9 3.5 2 2 1 3 3 3 1 Tetratricopeptide repeat Atu4866 PF11512.3 KOO24426.1 - 0.028 14.1 0.0 0.11 12.1 0.0 2.1 1 0 0 1 1 1 0 Agrobacterium tumefaciens protein Atu4866 TPR_14 PF13428.1 KOO24426.1 - 0.066 13.8 23.1 0.55 11.0 0.3 5.8 5 1 1 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO24426.1 - 1.5 9.4 6.9 14 6.4 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Fasciclin PF02469.17 KOO24428.1 - 4.2e-33 114.0 0.0 7.9e-33 113.1 0.0 1.5 1 0 0 1 1 1 1 Fasciclin domain S1 PF00575.18 KOO24428.1 - 1.9e-30 104.7 7.5 1.3e-16 60.4 2.6 2.6 1 1 1 2 2 2 2 S1 RNA binding domain S1_2 PF13509.1 KOO24428.1 - 0.00062 19.6 0.0 0.29 11.0 0.0 2.7 1 1 1 2 2 2 2 S1 domain CSD PF00313.17 KOO24428.1 - 0.0043 16.7 2.7 0.042 13.6 0.9 2.4 1 1 1 2 2 2 1 'Cold-shock' DNA-binding domain CRAL_TRIO PF00650.15 KOO24429.1 - 4.1e-27 94.6 0.0 5.7e-27 94.1 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 KOO24429.1 - 6.4e-05 23.0 0.0 0.00015 21.7 0.0 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 KOO24429.1 - 0.19 11.6 0.0 0.41 10.5 0.0 1.6 1 1 0 1 1 1 0 Divergent CRAL/TRIO domain Cyt-b5 PF00173.23 KOO24430.1 - 8.9e-13 47.8 0.0 1.6e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain PsaD PF02531.11 KOO24431.1 - 5e-06 25.7 0.0 6.2e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 PsaD Apelin PF15360.1 KOO24431.1 - 0.62 10.3 3.8 1.5 9.1 2.0 2.0 2 0 0 2 2 2 0 APJ endogenous ligand OTU PF02338.14 KOO24432.1 - 1.6e-19 70.6 2.3 4e-19 69.3 0.1 2.1 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 KOO24432.1 - 9.5e-07 28.4 0.0 0.00061 19.2 0.0 2.5 3 0 0 3 3 3 2 Peptidase C65 Otubain CDC37_C PF08564.5 KOO24432.1 - 0.95 9.3 6.8 2.7 7.8 4.6 1.9 1 1 0 1 1 1 0 Cdc37 C terminal domain Pkinase PF00069.20 KOO24433.1 - 1.8e-09 37.1 0.0 2.4e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO24433.1 - 8.6e-05 21.7 0.0 0.00065 18.8 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase UAA PF08449.6 KOO24434.1 - 5.7e-54 183.0 18.6 5.7e-54 183.0 12.9 2.4 2 1 0 2 2 2 1 UAA transporter family TPT PF03151.11 KOO24434.1 - 4.5e-05 23.1 13.6 4.5e-05 23.1 9.4 4.5 4 0 0 4 4 4 2 Triose-phosphate Transporter family Herpes_gE PF02480.11 KOO24434.1 - 0.2 9.8 0.1 0.82 7.8 0.1 1.9 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E C2 PF00168.25 KOO24435.1 - 5.8e-57 189.5 0.4 2.4e-14 52.9 0.0 8.9 8 1 1 9 9 9 6 C2 domain FerI PF08151.7 KOO24435.1 - 6.8e-08 32.4 0.0 2.1e-07 30.8 0.0 1.9 1 0 0 1 1 1 1 FerI (NUC094) domain Cytochrome-c551 PF10643.4 KOO24435.1 - 1 8.5 0.1 2.3 7.4 0.1 1.5 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 DUF2475 PF10629.4 KOO24436.1 - 5.5e-05 23.3 6.0 0.012 15.8 0.1 3.4 3 1 0 3 3 3 2 Protein of unknown function (DUF2475) LRR_6 PF13516.1 KOO24438.1 - 2.2e-10 39.4 4.2 0.0043 16.9 0.2 5.3 4 1 1 5 5 5 2 Leucine Rich repeat LRR_4 PF12799.2 KOO24438.1 - 7.3e-06 25.4 1.1 0.075 12.6 0.3 5.0 5 0 0 5 5 5 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO24438.1 - 0.0023 17.7 2.6 27 5.3 0.0 5.5 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_8 PF13855.1 KOO24438.1 - 0.0025 17.5 0.6 3.7 7.3 0.1 3.9 4 0 0 4 4 4 1 Leucine rich repeat LRR_7 PF13504.1 KOO24438.1 - 0.013 15.5 6.7 35 5.2 0.1 5.3 5 0 0 5 5 5 0 Leucine rich repeat Abhydrolase_5 PF12695.2 KOO24440.1 - 7.5e-16 58.1 0.2 1.2e-15 57.4 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO24440.1 - 2.1e-12 47.4 3.1 3.5e-12 46.7 1.6 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO24440.1 - 0.0014 18.2 0.2 0.0026 17.3 0.1 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.8 KOO24440.1 - 0.0079 15.6 0.0 0.014 14.8 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.3 KOO24440.1 - 0.016 15.0 0.0 0.029 14.2 0.0 1.4 1 0 0 1 1 1 0 Putative lysophospholipase Peptidase_S15 PF02129.13 KOO24440.1 - 0.018 14.4 0.0 0.032 13.6 0.0 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Glyco_transf_8 PF01501.15 KOO24442.1 - 2.8e-07 30.1 0.0 4.2e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 Ank_2 PF12796.2 KOO24443.1 - 2e-34 117.8 7.3 1.1e-14 54.5 0.1 3.8 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO24443.1 - 1.3e-30 103.6 14.7 3.4e-07 29.7 0.1 6.6 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.1 KOO24443.1 - 3.4e-19 68.8 4.3 1.1e-06 28.9 0.0 5.3 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO24443.1 - 8.5e-19 65.7 3.2 0.012 15.8 0.0 6.2 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.1 KOO24443.1 - 2.2e-18 65.8 11.7 9.7e-06 25.6 0.1 5.6 2 2 3 5 5 5 4 Ankyrin repeats (many copies) PMSI1 PF15322.1 KOO24444.1 - 0.0085 15.2 5.0 0.0096 15.0 3.5 1.0 1 0 0 1 1 1 1 Protein missing in infertile sperm 1, putative Cgr1 PF03879.9 KOO24444.1 - 0.016 15.3 20.6 0.023 14.8 14.3 1.2 1 0 0 1 1 1 0 Cgr1 family Mnd1 PF03962.10 KOO24444.1 - 0.23 11.1 11.0 0.28 10.8 7.6 1.1 1 0 0 1 1 1 0 Mnd1 family PVL_ORF50 PF07768.6 KOO24444.1 - 1.4 8.9 13.3 1.3 8.9 8.6 1.5 1 1 0 1 1 1 0 PVL ORF-50-like family TPR_11 PF13414.1 KOO24445.1 - 7.3e-08 31.9 4.0 0.00017 21.1 0.1 3.0 2 1 1 3 3 3 2 TPR repeat TPR_17 PF13431.1 KOO24445.1 - 9.2e-08 31.7 1.9 0.013 15.6 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO24445.1 - 0.0016 19.0 4.5 0.0016 19.0 3.1 3.5 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO24445.1 - 0.044 14.4 18.3 0.39 11.4 0.4 5.0 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO24445.1 - 1.5 8.8 6.5 19 5.5 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.1 KOO24445.1 - 2.4 8.5 14.3 1.9 8.9 0.4 4.1 2 1 2 4 4 4 0 Tetratricopeptide repeat SVS_QK PF10578.4 KOO24446.1 - 1.5 9.3 3.0 2.4 8.6 0.3 2.3 2 0 0 2 2 2 0 Seminal vesicle protein repeat Vfa1 PF08432.5 KOO24447.1 - 6.1 6.8 28.2 11 6.0 6.6 2.6 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Amidoligase_2 PF12224.3 KOO24449.1 - 1.7e-08 34.4 1.5 0.00018 21.2 0.0 3.0 3 0 0 3 3 3 2 Putative amidoligase enzyme TIG PF01833.19 KOO24450.1 - 1.5e-16 60.1 0.4 0.00022 21.1 0.0 4.0 3 1 1 4 4 4 3 IPT/TIG domain VCBS PF13517.1 KOO24452.1 - 1.7e-102 335.7 131.1 3.3e-14 52.9 2.2 10.5 1 1 9 10 10 10 10 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO24452.1 - 3.5e-55 182.5 112.7 3.7e-06 26.4 1.3 11.5 11 0 0 11 11 11 11 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO24452.1 - 7.9e-18 64.5 45.1 0.15 11.5 0.0 11.2 4 3 7 11 11 11 10 Insecticide toxin TcdB middle/N-terminal region GCC2_GCC3 PF07699.8 KOO24452.1 - 6.3e-12 44.8 60.4 1.3e-07 31.0 1.0 8.2 5 2 3 9 9 9 3 GCC2 and GCC3 Arrestin_N PF00339.24 KOO24452.1 - 0.13 12.0 0.0 2.6e+02 1.3 0.0 5.5 9 0 0 9 9 9 0 Arrestin (or S-antigen), N-terminal domain GldM_N PF12081.3 KOO24452.1 - 0.83 9.1 0.1 1.7 8.1 0.1 1.4 1 0 0 1 1 1 0 GldM N-terminal domain Mito_carr PF00153.22 KOO24453.1 - 2.7e-39 132.7 2.3 4.9e-19 67.8 0.0 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein SET PF00856.23 KOO24456.1 - 0.00079 19.7 0.0 0.086 13.1 0.0 2.3 2 0 0 2 2 2 2 SET domain TIG PF01833.19 KOO24457.1 - 1.6e-07 31.2 0.5 0.073 13.0 0.0 3.7 3 0 0 3 3 3 3 IPT/TIG domain Galactosyl_T PF01762.16 KOO24458.1 - 2e-06 27.5 0.0 0.058 12.9 0.0 2.1 2 0 0 2 2 2 2 Galactosyltransferase Arm PF00514.18 KOO24460.1 - 1.4e-57 189.7 36.2 2.4e-08 33.5 0.3 9.2 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.4 KOO24460.1 - 5.8e-07 29.1 4.6 0.01 15.5 0.0 4.6 3 2 2 5 5 5 3 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.8 KOO24460.1 - 1.4e-05 24.3 1.8 0.012 14.6 0.2 3.4 1 1 3 4 4 4 4 Armadillo-like RPAP1_C PF08620.5 KOO24460.1 - 1.7e-05 24.6 0.0 43 4.0 0.0 6.0 6 0 0 6 6 6 0 RPAP1-like, C-terminal HEAT_2 PF13646.1 KOO24460.1 - 0.016 15.4 2.7 0.016 15.4 1.9 4.7 1 1 3 4 4 4 0 HEAT repeats Peptidase_S41 PF03572.13 KOO24460.1 - 0.054 12.9 1.2 19 4.6 0.3 4.2 1 1 0 2 2 2 0 Peptidase family S41 SAM_1 PF00536.25 KOO24460.1 - 0.11 12.6 0.0 0.34 11.1 0.0 1.8 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) DUF1676 PF07898.8 KOO24460.1 - 0.12 12.7 0.3 1.7e+02 2.5 0.0 4.9 1 1 6 7 7 7 0 Protein of unknown function (DUF1676) N1221 PF07923.8 KOO24460.1 - 0.33 9.7 0.7 39 2.9 0.1 3.6 1 1 3 4 4 4 0 N1221-like protein SPOUT_MTase PF02590.12 KOO24460.1 - 5.1 6.7 6.5 45 3.7 0.1 3.8 3 2 2 6 6 6 0 Predicted SPOUT methyltransferase HEAT_EZ PF13513.1 KOO24460.1 - 5.5 7.6 30.7 0.26 11.8 0.6 5.9 3 1 2 6 6 6 0 HEAT-like repeat Ubie_methyltran PF01209.13 KOO24461.1 - 1.4e-83 279.5 0.0 1.6e-83 279.3 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.7 KOO24461.1 - 1.4e-16 60.6 0.0 5.6e-16 58.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO24461.1 - 1.4e-12 47.7 0.0 5e-12 46.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO24461.1 - 7.9e-12 45.0 0.0 1.3e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO24461.1 - 2.3e-10 40.4 0.0 3.4e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO24461.1 - 2.8e-10 40.5 0.0 7.9e-10 39.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO24461.1 - 1e-08 35.7 0.0 2.5e-08 34.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO24461.1 - 1.3e-07 31.6 0.1 3e-07 30.4 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 KOO24461.1 - 8.3e-07 28.8 0.0 1.3e-05 24.9 0.0 2.1 2 0 0 2 2 2 1 Hypothetical methyltransferase Methyltransf_29 PF03141.11 KOO24461.1 - 0.026 12.8 0.1 0.039 12.2 0.1 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase MTS PF05175.9 KOO24461.1 - 0.1 11.9 0.0 2.9 7.2 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase small domain NNMT_PNMT_TEMT PF01234.12 KOO24461.1 - 0.11 11.3 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Methyltransf_2 PF00891.13 KOO24461.1 - 0.13 11.4 0.2 0.32 10.1 0.1 1.7 2 0 0 2 2 2 0 O-methyltransferase AMPKBI PF04739.10 KOO24462.1 - 1.2e-07 31.5 0.0 3.1e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interation domain WEMBL PF05701.6 KOO24462.1 - 0.0023 16.4 19.9 0.0023 16.4 13.8 4.9 2 2 3 5 5 5 2 Weak chloroplast movement under blue light ADPrib_exo_Tox PF03496.9 KOO24463.1 - 6.3e-08 32.0 0.0 2.2e-07 30.3 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme ART PF01129.13 KOO24463.1 - 1.3e-05 24.3 0.0 2.3e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase zf-C2H2_3 PF13878.1 KOO24463.1 - 0.19 11.2 0.2 0.42 10.2 0.2 1.5 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO UBX PF00789.15 KOO24464.1 - 3.3e-06 27.0 0.0 4.1e-06 26.7 0.0 1.3 1 1 0 1 1 1 1 UBX domain Peptidase_S28 PF05577.7 KOO24465.1 - 1.1e-86 291.1 0.0 1.2e-86 290.9 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S37 PF05576.6 KOO24465.1 - 0.032 12.7 0.0 0.19 10.1 0.0 1.9 2 0 0 2 2 2 0 PS-10 peptidase S37 Peptidase_S9 PF00326.16 KOO24465.1 - 0.034 13.3 0.0 0.056 12.6 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family LRR_4 PF12799.2 KOO24466.1 - 7.5e-12 44.5 11.1 8.8e-06 25.2 1.5 4.1 2 1 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO24466.1 - 1.2e-10 40.9 6.4 6.6e-05 22.5 1.5 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.28 KOO24466.1 - 8.5e-08 31.2 6.6 0.16 12.0 0.0 5.4 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_6 PF13516.1 KOO24466.1 - 0.25 11.5 5.7 20 5.6 0.3 4.5 3 1 1 4 4 4 0 Leucine Rich repeat LRR_7 PF13504.1 KOO24466.1 - 0.52 10.7 10.4 15 6.2 0.0 4.8 4 1 0 4 4 4 0 Leucine rich repeat Methyltransf_23 PF13489.1 KOO24467.1 - 1.2e-05 25.1 0.0 2.1e-05 24.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO24467.1 - 0.02 15.3 0.0 0.037 14.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 KOO24467.1 - 0.077 13.4 0.0 0.18 12.3 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.7 KOO24467.1 - 0.11 11.9 0.0 0.63 9.3 0.0 2.0 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW Ribosomal_S20p PF01649.13 KOO24468.1 - 1.5e-21 76.5 7.7 2.1e-21 76.0 5.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S20 Exonuc_VII_L PF02601.10 KOO24468.1 - 0.008 15.4 1.8 0.0099 15.1 1.3 1.0 1 0 0 1 1 1 1 Exonuclease VII, large subunit DUF4330 PF14221.1 KOO24468.1 - 0.0088 15.9 0.1 0.013 15.3 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4330) Striatin PF08232.7 KOO24468.1 - 0.047 14.0 2.8 0.16 12.2 1.9 1.9 1 1 0 1 1 1 0 Striatin family PhrC_PhrF PF11131.3 KOO24468.1 - 0.31 10.6 2.3 0.97 9.0 1.4 2.1 1 1 1 2 2 2 0 Rap-phr extracellular signalling Ras PF00071.17 KOO24469.1 - 3.3e-53 179.3 0.0 3.8e-53 179.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO24469.1 - 2.1e-17 63.7 0.0 2.9e-17 63.2 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO24469.1 - 1.2e-11 44.1 0.0 1.4e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 KOO24469.1 - 0.0012 18.8 0.0 0.0025 17.7 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 KOO24469.1 - 0.0066 15.9 0.0 0.013 14.9 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 KOO24469.1 - 0.016 14.3 0.0 0.028 13.5 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.5 KOO24469.1 - 0.052 12.7 0.0 0.15 11.2 0.0 1.7 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit FeoB_N PF02421.13 KOO24469.1 - 0.13 11.5 0.0 2.8 7.1 0.0 2.3 1 1 0 1 1 1 0 Ferrous iron transport protein B UFD1 PF03152.9 KOO24470.1 - 1.1e-66 223.2 0.0 1.3e-66 223.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 PAH PF02671.16 KOO24473.1 - 6.5e-20 70.4 0.6 9.8e-20 69.9 0.4 1.3 1 0 0 1 1 1 1 Paired amphipathic helix repeat Rrn6 PF10214.4 KOO24473.1 - 0.11 10.6 0.0 0.12 10.4 0.0 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor UDPGP PF01704.13 KOO24474.1 - 1.8e-06 26.7 0.0 2.8e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase EF-hand_1 PF00036.27 KOO24475.1 - 5e-25 84.8 7.5 1.1e-06 27.5 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO24475.1 - 2.4e-21 73.6 6.4 0.00017 21.1 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO24475.1 - 6.6e-21 72.6 2.7 0.00015 20.9 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO24475.1 - 7.4e-21 74.0 5.6 5e-10 39.3 0.4 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO24475.1 - 5.3e-15 54.7 3.2 3.9e-06 26.3 0.0 3.9 2 2 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO24475.1 - 4.5e-09 36.3 3.6 0.0017 18.3 0.4 2.5 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO24475.1 - 1.9e-06 27.4 0.9 0.051 13.2 0.1 3.2 2 1 1 3 3 3 2 EF hand EF-hand_4 PF12763.2 KOO24475.1 - 7.6e-06 25.6 1.7 0.0019 17.8 0.1 2.8 2 2 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand Toprim_2 PF13155.1 KOO24475.1 - 0.0011 19.2 1.0 0.67 10.3 0.2 3.0 1 1 0 2 2 2 1 Toprim-like Metal_resist PF13801.1 KOO24475.1 - 0.0077 16.2 0.2 0.025 14.5 0.1 1.9 1 0 0 1 1 1 1 Heavy-metal resistance PMBR PF09373.5 KOO24475.1 - 0.042 13.8 0.0 0.92 9.5 0.0 2.9 2 0 0 2 2 2 0 Pseudomurein-binding repeat PBP_GOBP PF01395.17 KOO24475.1 - 0.057 13.0 1.6 0.54 9.8 1.2 2.2 2 0 0 2 2 2 0 PBP/GOBP family MpPF1 PF07668.6 KOO24475.1 - 0.058 12.5 2.1 0.066 12.3 0.2 1.8 1 1 0 2 2 2 0 M penetrans paralogue family 1 Toprim PF01751.17 KOO24475.1 - 0.18 11.7 7.0 0.67 9.9 0.9 3.2 1 1 1 3 3 3 0 Toprim domain DUF4230 PF14014.1 KOO24475.1 - 6 6.7 10.6 4.6 7.0 1.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4230) DUF2870 PF11069.3 KOO24477.1 - 4e-33 113.3 2.0 7.4e-33 112.5 1.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2870) Pentapeptide_4 PF13599.1 KOO24478.1 - 6.6e-79 259.7 0.0 3.9e-07 29.7 0.0 14.8 3 2 10 13 13 13 13 Pentapeptide repeats (9 copies) XK-related PF09815.4 KOO24478.1 - 0.0015 17.5 6.9 0.0035 16.4 4.8 1.6 1 0 0 1 1 1 1 XK-related protein Ribosomal_L13e PF01294.13 KOO24478.1 - 0.0016 17.9 23.7 15 5.0 0.0 12.9 8 3 4 13 13 13 1 Ribosomal protein L13e Toxin_54 PF15533.1 KOO24478.1 - 0.0024 18.1 5.9 1.1e+02 3.0 0.0 9.1 7 2 1 8 8 8 0 Putative toxin 54 Acetyltransf_11 PF13720.1 KOO24478.1 - 0.033 14.4 0.2 85 3.4 0.0 5.6 5 0 0 5 5 5 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Arteri_GP4 PF02497.10 KOO24478.1 - 0.049 13.5 0.2 26 4.7 0.0 4.5 4 1 1 5 5 5 0 Arterivirus glycoprotein SSFA2_C PF14723.1 KOO24478.1 - 0.099 12.3 3.3 0.21 11.3 2.3 1.4 1 0 0 1 1 1 0 Sperm-specific antigen 2 C-terminus Ole-e-6 PF09253.5 KOO24478.1 - 9.1 6.0 9.6 89 2.8 0.0 7.1 7 0 0 7 7 7 0 Pollen allergen ole e 6 HEAT PF02985.17 KOO24479.1 - 1.4e-15 55.9 26.7 0.012 15.6 0.0 10.2 9 1 0 9 9 9 6 HEAT repeat HEAT_2 PF13646.1 KOO24479.1 - 4.9e-12 45.9 21.0 0.00053 20.2 0.1 6.0 3 1 2 5 5 5 5 HEAT repeats HEAT_EZ PF13513.1 KOO24479.1 - 0.052 14.0 27.5 3.2 8.3 0.3 8.1 5 3 4 9 9 9 0 HEAT-like repeat Arm PF00514.18 KOO24479.1 - 1.7 8.6 9.6 13 5.8 0.3 4.8 4 1 0 4 4 4 0 Armadillo/beta-catenin-like repeat Lipase_3 PF01764.20 KOO24480.1 - 1.1e-10 41.2 0.0 2.3e-10 40.2 0.0 1.6 1 1 0 1 1 1 1 Lipase (class 3) WW PF00397.21 KOO24480.1 - 1.4e-05 24.8 1.9 2.6e-05 23.9 1.3 1.4 1 0 0 1 1 1 1 WW domain Abhydrolase_5 PF12695.2 KOO24480.1 - 0.00028 20.6 0.0 0.00059 19.6 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO24480.1 - 0.00054 19.9 4.2 0.00054 19.9 2.9 1.7 1 1 1 2 2 2 1 Alpha/beta hydrolase family Thioesterase PF00975.15 KOO24480.1 - 0.042 14.0 0.1 0.09 12.9 0.1 1.5 1 0 0 1 1 1 0 Thioesterase domain PGAP1 PF07819.8 KOO24480.1 - 0.075 12.6 0.1 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Pkinase PF00069.20 KOO24481.1 - 5.1e-51 173.3 0.0 6.3e-51 173.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO24481.1 - 1.1e-19 70.4 0.0 1.8e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO24481.1 - 5.6e-05 22.2 0.0 0.00021 20.3 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOO24481.1 - 0.00073 18.6 0.0 0.0011 18.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO24481.1 - 0.0036 17.0 0.5 0.009 15.7 0.0 1.8 2 1 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 KOO24481.1 - 0.023 14.0 0.0 0.076 12.3 0.0 1.7 2 0 0 2 2 2 0 RIO1 family YrbL-PhoP_reg PF10707.4 KOO24481.1 - 0.024 13.9 0.0 0.035 13.4 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL PapD-like PF14874.1 KOO24482.1 - 5.2e-10 39.1 0.9 0.013 15.3 0.0 6.9 8 0 0 8 8 8 3 Flagellar-associated PapD-like RRM_1 PF00076.17 KOO24483.1 - 3.3e-12 45.8 0.0 5.9e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO24483.1 - 3.4e-10 39.7 0.0 5.9e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO24483.1 - 1.1e-05 25.1 0.0 2e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UCH PF00443.24 KOO24484.1 - 5.2e-42 143.8 0.0 6.8e-42 143.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.7 KOO24484.1 - 8.8e-16 58.1 0.0 1.7e-15 57.1 0.0 1.5 1 0 0 1 1 1 1 DUSP domain UCH_1 PF13423.1 KOO24484.1 - 3.4e-12 46.4 0.0 4.8e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_3 PF14836.1 KOO24484.1 - 0.00034 20.1 0.0 0.00068 19.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain USP7_C2 PF14533.1 KOO24484.1 - 0.0027 17.1 0.0 0.27 10.6 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-specific protease C-terminal Inositol_P PF00459.20 KOO24485.1 - 3.7e-22 78.9 0.1 6.2e-22 78.1 0.1 1.3 1 0 0 1 1 1 1 Inositol monophosphatase family Clathrin_H_link PF13838.1 KOO24485.1 - 0.5 10.2 3.2 11 6.0 0.2 2.7 1 1 1 2 2 2 0 Clathrin-H-link TruD PF01142.13 KOO24486.1 - 4.7e-27 94.6 0.0 6.8e-27 94.0 0.0 1.2 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) P53_C PF11619.3 KOO24487.1 - 0.15 11.7 0.2 0.28 10.9 0.1 1.4 1 0 0 1 1 1 0 Transcription factor P53 - C terminal domain DUF3125 PF11323.3 KOO24488.1 - 0.014 15.1 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3125) LRR_5 PF13306.1 KOO24489.1 - 1.5e-95 315.6 0.0 3.6e-35 120.4 0.0 3.1 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO24489.1 - 1.1e-28 98.7 0.0 1.4e-05 24.7 0.0 6.9 2 1 5 7 7 7 6 Leucine rich repeat TruD PF01142.13 KOO24490.1 - 1.4e-07 30.5 0.0 1.6e-07 30.3 0.0 1.0 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) OTU PF02338.14 KOO24491.1 - 2.3e-11 44.3 0.1 7.9e-11 42.5 0.1 2.0 1 0 0 1 1 1 1 OTU-like cysteine protease DUF3584 PF12128.3 KOO24491.1 - 0.0013 16.1 6.3 0.0018 15.6 4.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Peptidase_C65 PF10275.4 KOO24491.1 - 0.0014 18.0 2.5 0.14 11.5 0.0 2.5 3 0 0 3 3 3 2 Peptidase C65 Otubain AAA_13 PF13166.1 KOO24491.1 - 0.0058 15.1 1.4 0.0084 14.6 1.0 1.1 1 0 0 1 1 1 1 AAA domain APG6 PF04111.7 KOO24491.1 - 0.021 13.8 6.8 0.037 13.0 4.7 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 Reo_sigmaC PF04582.7 KOO24491.1 - 0.085 12.0 1.5 0.15 11.2 1.0 1.5 1 0 0 1 1 1 0 Reovirus sigma C capsid protein rRNA_proc-arch PF13234.1 KOO24491.1 - 0.18 10.9 2.4 3.3 6.8 0.7 2.2 1 1 1 2 2 2 0 rRNA-processing arch domain IncA PF04156.9 KOO24491.1 - 0.22 11.1 13.4 0.49 9.9 9.3 1.6 1 0 0 1 1 1 0 IncA protein WEMBL PF05701.6 KOO24491.1 - 0.23 9.8 19.0 0.046 12.1 5.2 2.0 1 1 1 2 2 2 0 Weak chloroplast movement under blue light Spc7 PF08317.6 KOO24491.1 - 0.33 9.5 7.7 0.82 8.2 5.0 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.4 KOO24491.1 - 1.8 8.4 10.7 3.2 7.6 6.6 2.0 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3450 PF11932.3 KOO24491.1 - 2 7.6 12.5 0.13 11.4 2.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Arm PF00514.18 KOO24493.1 - 4.6e-68 222.9 67.5 8.6e-06 25.3 0.4 23.2 23 2 1 24 24 24 16 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.4 KOO24493.1 - 7.4e-11 41.6 9.1 0.075 12.7 0.0 8.0 6 2 3 9 9 9 4 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.8 KOO24493.1 - 1.8e-08 33.7 11.0 1.8 7.6 0.0 8.8 5 2 5 10 10 10 4 Armadillo-like HEAT_2 PF13646.1 KOO24493.1 - 2.1e-08 34.3 71.4 0.0031 17.7 0.5 10.2 5 2 5 11 11 11 7 HEAT repeats V-ATPase_H_N PF03224.9 KOO24493.1 - 0.00094 18.3 3.4 2.3 7.2 0.0 4.5 2 1 0 2 2 2 2 V-ATPase subunit H HEAT PF02985.17 KOO24493.1 - 0.64 10.2 24.4 6.6 7.0 0.0 10.1 11 0 0 11 11 11 0 HEAT repeat HEAT_EZ PF13513.1 KOO24493.1 - 0.68 10.5 57.2 0.73 10.3 0.0 11.9 9 4 3 12 12 12 0 HEAT-like repeat Mis12 PF05859.7 KOO24494.1 - 1.2e-18 67.2 0.2 2.1e-18 66.5 0.1 1.4 1 0 0 1 1 1 1 Mis12 protein DivIVA PF05103.8 KOO24494.1 - 0.021 14.8 1.5 0.042 13.8 1.0 1.5 1 0 0 1 1 1 0 DivIVA protein H-kinase_dim PF02895.9 KOO24494.1 - 0.18 12.1 2.9 3.6 7.9 2.0 2.5 1 1 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain Syntaxin-6_N PF09177.6 KOO24494.1 - 0.58 10.5 3.1 23 5.4 0.0 2.4 2 1 0 2 2 2 0 Syntaxin 6, N-terminal adh_short PF00106.20 KOO24495.1 - 2.3e-08 34.1 0.1 2.3e-08 34.1 0.1 2.0 3 0 0 3 3 3 1 short chain dehydrogenase Cyclin_N PF00134.18 KOO24496.1 - 2.8e-25 88.3 0.2 4.8e-25 87.5 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Pkinase PF00069.20 KOO24496.1 - 2.2e-17 63.0 0.0 3.3e-17 62.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Gly_transf_sug PF04488.10 KOO24496.1 - 1.1e-07 32.2 0.0 2.6e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Pkinase_Tyr PF07714.12 KOO24496.1 - 2.1e-05 23.7 0.0 4.4e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase F-box-like PF12937.2 KOO24496.1 - 0.013 15.2 0.0 0.044 13.5 0.0 1.9 1 1 0 1 1 1 0 F-box-like TcdA_TcdB PF12919.2 KOO24496.1 - 0.1 11.0 0.0 0.42 9.0 0.0 1.7 2 0 0 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain DUF2611 PF11022.3 KOO24497.1 - 1.6 8.8 3.8 11 6.2 0.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2611) 2OG-FeII_Oxy_3 PF13640.1 KOO24498.1 - 2.7e-13 50.2 0.0 5.5e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO24498.1 - 0.0043 16.6 0.0 0.012 15.2 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Abhydrolase_5 PF12695.2 KOO24500.1 - 3e-10 40.0 0.1 6e-10 39.0 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO24500.1 - 4.9e-05 23.3 3.0 7.5e-05 22.7 2.1 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family PAF-AH_p_II PF03403.8 KOO24500.1 - 0.003 15.8 0.0 0.0044 15.3 0.0 1.2 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase PF07224.6 KOO24500.1 - 0.0093 14.7 0.0 0.014 14.2 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase DLH PF01738.13 KOO24500.1 - 0.02 14.2 0.0 0.036 13.3 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family Chlorophyllase2 PF12740.2 KOO24500.1 - 0.023 13.5 0.0 0.049 12.5 0.0 1.5 1 1 0 1 1 1 0 Chlorophyllase enzyme Hydrolase_4 PF12146.3 KOO24500.1 - 0.059 13.2 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Putative lysophospholipase FAD_binding_4 PF01565.18 KOO24502.1 - 9.7e-12 44.5 0.1 1.7e-11 43.7 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pkinase_Tyr PF07714.12 KOO24504.1 - 8.2e-47 159.4 0.1 2.4e-42 144.8 0.0 2.9 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 KOO24504.1 - 1.3e-46 158.8 0.0 2.1e-46 158.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 KOO24504.1 - 0.0016 18.2 0.0 0.0029 17.3 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family YukC PF10140.4 KOO24504.1 - 0.046 12.2 0.0 0.075 11.5 0.0 1.4 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC E1-E2_ATPase PF00122.15 KOO24505.1 - 1.1e-41 142.3 1.1 1.7e-41 141.8 0.1 1.7 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 KOO24505.1 - 1.9e-38 133.0 0.1 3.5e-38 132.1 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO24505.1 - 3.5e-09 37.1 0.0 5.8e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 KOO24505.1 - 3.9e-05 23.3 0.1 0.00038 20.0 0.2 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase ACP_syn_III_C PF08541.5 KOO24506.1 - 0.0025 17.8 0.0 0.0063 16.5 0.0 1.7 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ArsC PF03960.10 KOO24506.1 - 0.012 15.6 1.3 0.012 15.6 0.9 2.0 1 1 0 2 2 2 0 ArsC family MxiH PF09392.5 KOO24506.1 - 0.059 13.9 0.4 0.19 12.3 0.3 2.0 1 1 0 1 1 1 0 Type III secretion needle MxiH like SseC PF04888.7 KOO24506.1 - 7.7 5.7 9.4 2 7.6 3.9 1.9 2 1 0 2 2 2 0 Secretion system effector C (SseC) like family EF-hand_5 PF13202.1 KOO24507.1 - 8.9e-05 21.6 0.1 0.0002 20.5 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO24507.1 - 0.00012 21.7 0.1 0.00031 20.3 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.27 KOO24507.1 - 0.00013 20.9 0.0 0.00034 19.7 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO24507.1 - 0.00026 21.0 0.2 0.00086 19.3 0.2 1.8 1 0 0 1 1 1 1 EF-hand domain pair TPR_2 PF07719.12 KOO24507.1 - 0.00074 19.2 0.1 0.036 13.9 0.0 3.6 2 1 0 2 2 2 1 Tetratricopeptide repeat EF-hand_8 PF13833.1 KOO24507.1 - 0.0019 17.8 0.1 0.013 15.0 0.0 2.5 3 0 0 3 3 3 1 EF-hand domain pair TPR_1 PF00515.23 KOO24507.1 - 0.0023 17.4 0.0 0.01 15.4 0.0 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO24507.1 - 0.023 15.3 1.2 1.8 9.3 0.1 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO24507.1 - 0.11 12.3 0.0 0.11 12.3 0.0 4.3 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO24507.1 - 0.33 11.6 4.1 1.5 9.6 0.0 4.1 3 1 0 3 3 3 0 Tetratricopeptide repeat EF-hand_5 PF13202.1 KOO24508.1 - 0.0001 21.4 0.0 0.00019 20.6 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KOO24508.1 - 0.0011 18.0 0.0 0.0022 17.1 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO24508.1 - 0.017 14.9 0.0 0.046 13.6 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.1 KOO24508.1 - 0.04 14.0 0.0 0.077 13.1 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair DUF4131 PF13567.1 KOO24508.1 - 0.06 12.7 1.6 0.65 9.3 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) EF-hand_8 PF13833.1 KOO24508.1 - 0.09 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair MRAP PF15183.1 KOO24508.1 - 0.32 10.6 0.0 0.32 10.6 0.0 2.0 3 0 0 3 3 3 0 Melanocortin-2 receptor accessory protein family CMAS PF02353.15 KOO24510.1 - 8.2e-67 225.1 0.2 1e-66 224.8 0.1 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 KOO24510.1 - 2e-12 47.1 0.0 3.3e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO24510.1 - 1.2e-11 44.8 0.0 2.5e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO24510.1 - 3.8e-11 42.7 0.0 6.4e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO24510.1 - 1.3e-09 38.5 0.0 2.7e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO24510.1 - 8e-08 32.6 0.0 1.6e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOO24510.1 - 5.9e-07 29.0 0.0 1.2e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 KOO24510.1 - 3.2e-06 27.4 0.1 6.8e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.8 KOO24510.1 - 7.3e-06 25.4 0.2 7.9e-05 22.0 0.0 2.1 2 0 0 2 2 2 1 Histone methylation protein DOT1 Methyltransf_26 PF13659.1 KOO24510.1 - 7.8e-06 25.9 0.0 1.9e-05 24.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 KOO24510.1 - 0.0035 16.7 0.0 0.0058 16.0 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW GET2 PF08690.5 KOO24510.1 - 0.0041 16.4 0.0 0.0062 15.8 0.0 1.2 1 0 0 1 1 1 1 GET complex subunit GET2 PCMT PF01135.14 KOO24510.1 - 0.015 14.8 0.0 0.032 13.7 0.0 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.12 KOO24510.1 - 0.085 11.8 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Ubie_methyltran PF01209.13 KOO24510.1 - 0.086 11.9 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family MORN PF02493.15 KOO24511.1 - 0.0014 18.2 4.0 0.041 13.6 0.0 3.3 3 0 0 3 3 3 2 MORN repeat Spermine_synth PF01564.12 KOO24511.1 - 0.28 10.0 0.0 0.48 9.3 0.0 1.2 1 0 0 1 1 1 0 Spermine/spermidine synthase HAD_2 PF13419.1 KOO24513.1 - 3.3e-13 50.2 2.9 1.2e-12 48.4 0.0 3.3 3 1 0 3 3 3 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOO24513.1 - 1.2e-08 34.5 0.1 3.7e-08 32.9 0.1 1.8 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.2 KOO24513.1 - 0.00057 20.1 0.2 0.0042 17.2 0.0 2.7 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase C2 PF00168.25 KOO24514.1 - 2.7e-37 126.4 0.0 1.8e-19 69.3 0.0 2.3 2 0 0 2 2 2 2 C2 domain WW PF00397.21 KOO24514.1 - 2.4e-20 72.0 11.2 1.7e-10 40.5 1.5 3.4 4 0 0 4 4 4 2 WW domain Cu_amine_oxidN3 PF02728.11 KOO24514.1 - 0.0008 19.4 0.3 1.4 8.9 0.0 2.5 2 0 0 2 2 2 2 Copper amine oxidase, N3 domain MbtH PF03621.8 KOO24514.1 - 0.063 12.6 0.5 13 5.1 0.0 2.4 2 0 0 2 2 2 0 MbtH-like protein Hydrolase_2 PF07486.7 KOO24514.1 - 0.19 12.2 0.9 27 5.3 0.0 2.6 2 0 0 2 2 2 0 Cell Wall Hydrolase Glyco_transf_29 PF00777.13 KOO24515.1 - 9.3e-27 93.8 0.4 9.4e-25 87.2 0.2 2.3 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Ank_2 PF12796.2 KOO24516.1 - 1.2e-11 44.8 3.4 1.6e-11 44.3 0.6 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO24516.1 - 1.2e-10 41.2 1.3 1.8e-05 24.8 0.5 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO24516.1 - 1.2e-08 34.2 2.6 0.00097 18.8 0.2 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOO24516.1 - 1.1e-07 32.1 0.6 0.00043 20.7 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO24516.1 - 0.00013 21.8 1.3 0.25 11.7 0.0 3.9 4 0 0 4 4 4 1 Ankyrin repeat DUF4182 PF13790.1 KOO24516.1 - 0.091 12.5 0.0 12 5.7 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4182) DUF4464 PF14713.1 KOO24517.1 - 2e-93 312.0 1.2 2.3e-93 311.9 0.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4464) AIRS_C PF02769.17 KOO24517.1 - 0.14 12.2 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 AIR synthase related protein, C-terminal domain GRP PF07172.6 KOO24518.1 - 0.0043 17.5 7.6 0.0076 16.7 5.3 1.4 1 0 0 1 1 1 1 Glycine rich protein family SAM_1 PF00536.25 KOO24518.1 - 0.0074 16.4 0.0 0.025 14.7 0.0 1.7 1 1 1 2 2 2 1 SAM domain (Sterile alpha motif) ATG16 PF08614.6 KOO24519.1 - 0.019 14.7 34.3 0.042 13.6 2.3 3.1 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) IncA PF04156.9 KOO24519.1 - 0.097 12.2 32.6 0.11 12.0 10.3 2.7 2 1 1 3 3 3 0 IncA protein Bacillus_HBL PF05791.6 KOO24519.1 - 0.13 11.6 12.9 0.33 10.2 4.3 2.3 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Reo_sigmaC PF04582.7 KOO24519.1 - 0.15 11.2 1.2 0.12 11.5 0.1 1.4 2 0 0 2 2 2 0 Reovirus sigma C capsid protein CytochromB561_N PF09786.4 KOO24519.1 - 0.24 9.8 5.1 0.27 9.6 3.5 1.2 1 0 0 1 1 1 0 Cytochrome B561, N terminal HR1 PF02185.11 KOO24519.1 - 0.73 9.6 21.1 0.13 12.0 0.8 3.2 2 1 1 3 3 3 0 Hr1 repeat DUF4404 PF14357.1 KOO24519.1 - 1.3 9.5 24.4 0.31 11.4 0.2 4.1 2 1 2 4 4 4 0 Domain of unknown function (DUF4404) DUF1515 PF07439.6 KOO24519.1 - 1.7 8.5 11.1 0.26 11.1 3.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) CtIP_N PF10482.4 KOO24519.1 - 2.1 8.1 17.8 0.029 14.1 5.4 2.8 3 1 0 3 3 3 0 Tumour-suppressor protein CtIP N-terminal domain Cob_adeno_trans PF01923.13 KOO24519.1 - 3.4 7.4 12.8 1.4 8.7 2.4 2.6 1 1 0 2 2 2 0 Cobalamin adenosyltransferase ALMT PF11744.3 KOO24519.1 - 4.7 5.7 11.6 6.4 5.3 8.0 1.4 1 1 0 1 1 1 0 Aluminium activated malate transporter Spc7 PF08317.6 KOO24519.1 - 5.9 5.4 28.0 3.2 6.3 12.0 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein SOBP PF15279.1 KOO24519.1 - 6.1 7.1 8.2 7 6.9 5.7 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Ycf1 PF05758.7 KOO24519.1 - 7 4.2 12.8 10 3.7 8.8 1.3 1 0 0 1 1 1 0 Ycf1 Thioesterase PF00975.15 KOO24520.1 - 4.1e-07 30.4 1.0 0.00064 20.0 0.2 2.4 2 0 0 2 2 2 2 Thioesterase domain Abhydrolase_1 PF00561.15 KOO24520.1 - 0.0027 17.3 0.3 0.0064 16.0 0.1 1.7 3 0 0 3 3 3 1 alpha/beta hydrolase fold Methyltransf_21 PF05050.7 KOO24521.1 - 0.00056 19.9 0.0 0.00058 19.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase FkbM domain PDZ PF00595.19 KOO24523.1 - 3e-24 85.0 1.1 9.5e-07 28.9 0.1 3.3 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) BolA PF01722.13 KOO24523.1 - 3.6e-18 65.2 0.0 7.3e-18 64.2 0.0 1.5 1 0 0 1 1 1 1 BolA-like protein PDZ_2 PF13180.1 KOO24523.1 - 8.9e-17 60.7 1.7 1.9e-05 24.4 0.0 3.3 3 0 0 3 3 3 3 PDZ domain Tricorn_PDZ PF14685.1 KOO24523.1 - 2.2e-05 24.1 1.0 0.56 10.0 0.0 3.7 3 0 0 3 3 3 2 Tricorn protease PDZ domain Pkinase PF00069.20 KOO24524.1 - 8.6e-66 221.7 0.0 1.2e-65 221.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO24524.1 - 1.2e-37 129.4 0.0 1.8e-37 128.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase cNMP_binding PF00027.24 KOO24524.1 - 8.9e-17 60.6 0.0 1.8e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain EF-hand_7 PF13499.1 KOO24524.1 - 5.1e-06 26.5 0.0 1.2e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair Kdo PF06293.9 KOO24524.1 - 1.7e-05 23.9 0.0 4.1e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_8 PF13833.1 KOO24524.1 - 0.00067 19.2 0.0 0.043 13.4 0.0 3.1 1 1 2 3 3 3 1 EF-hand domain pair Kinase-like PF14531.1 KOO24524.1 - 0.003 16.5 0.0 0.0055 15.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO24524.1 - 0.02 14.6 0.4 0.11 12.2 0.0 2.3 2 0 0 2 2 2 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 KOO24524.1 - 0.057 12.7 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL LRR_4 PF12799.2 KOO24525.1 - 6.7e-14 51.1 3.6 2.6e-07 30.1 0.0 2.6 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO24525.1 - 1.8e-05 24.3 0.7 4.5e-05 23.1 0.5 1.8 1 0 0 1 1 1 1 Leucine rich repeat LRR_7 PF13504.1 KOO24525.1 - 0.00048 19.8 0.6 0.53 10.7 0.0 4.0 3 0 0 3 3 3 1 Leucine rich repeat LRR_1 PF00560.28 KOO24525.1 - 0.0011 18.7 0.1 4 7.8 0.0 3.2 3 0 0 3 3 3 2 Leucine Rich Repeat Bclx_interact PF08945.5 KOO24525.1 - 0.033 13.7 0.0 0.1 12.1 0.0 1.9 1 0 0 1 1 1 0 Bcl-x interacting, BH3 domain RPA_interact_M PF14767.1 KOO24525.1 - 0.2 12.4 1.8 4.7 8.0 0.0 2.6 2 1 0 2 2 2 0 Replication protein A interacting middle GpcrRhopsn4 PF10192.4 KOO24527.1 - 0.0005 19.3 6.7 0.0005 19.3 4.6 1.6 1 1 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain Lung_7-TM_R PF06814.8 KOO24527.1 - 0.0011 17.9 17.9 0.0016 17.4 12.4 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor Atg8 PF02991.11 KOO24528.1 - 5.4e-42 141.9 0.2 8.8e-40 134.8 0.1 2.1 2 0 0 2 2 2 2 Autophagy protein Atg8 ubiquitin like APG12 PF04110.8 KOO24528.1 - 2.9e-06 27.3 0.0 4.6e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 SHIPPO-rpt PF07004.7 KOO24529.1 - 4.7e-11 42.9 13.5 0.6 11.1 0.1 8.5 8 0 0 8 8 8 5 Sperm-tail PG-rich repeat CRAL_TRIO PF00650.15 KOO24530.1 - 9e-19 67.5 0.0 9.8e-19 67.3 0.0 1.0 1 0 0 1 1 1 1 CRAL/TRIO domain EF-hand_5 PF13202.1 KOO24531.1 - 1.5e-07 30.4 2.9 6.4e-06 25.2 0.2 2.9 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.1 KOO24531.1 - 5.7e-07 28.8 0.4 0.00011 21.8 0.0 2.8 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.27 KOO24531.1 - 2.9e-06 26.1 0.0 0.00012 21.1 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.1 KOO24531.1 - 3.1e-05 23.5 0.1 0.041 13.4 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.1 KOO24531.1 - 7.9e-05 22.7 0.2 0.00017 21.6 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO24531.1 - 0.066 13.2 0.1 0.27 11.2 0.0 2.0 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region DUF4407 PF14362.1 KOO24531.1 - 0.68 8.8 11.0 0.13 11.1 3.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) PALP PF00291.20 KOO24532.1 - 6.8e-18 64.9 0.2 9.7e-18 64.4 0.2 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ABC_tran PF00005.22 KOO24533.1 - 5.4e-42 143.3 0.0 1.3e-24 87.1 0.0 2.3 2 0 0 2 2 2 2 ABC transporter ABC2_membrane PF01061.19 KOO24533.1 - 6e-32 110.5 58.9 1.2e-17 63.7 17.9 2.3 2 0 0 2 2 2 2 ABC-2 type transporter AAA_21 PF13304.1 KOO24533.1 - 3.6e-14 53.4 0.0 0.00044 20.3 0.0 3.2 3 0 0 3 3 3 3 AAA domain SbcCD_C PF13558.1 KOO24533.1 - 7.6e-06 25.7 0.2 0.082 12.8 0.0 3.3 2 1 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.1 KOO24533.1 - 0.00023 21.2 0.1 0.00069 19.6 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain DUF258 PF03193.11 KOO24533.1 - 0.00033 19.8 0.0 0.00067 18.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_15 PF13175.1 KOO24533.1 - 0.001 18.2 0.0 1.6 7.7 0.0 3.1 3 0 0 3 3 3 1 AAA ATPase domain AAA_25 PF13481.1 KOO24533.1 - 0.0033 16.8 0.4 0.9 8.9 0.1 3.1 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.1 KOO24533.1 - 0.0058 16.7 0.1 0.021 14.9 0.0 2.1 2 1 0 2 2 1 1 AAA domain SMC_N PF02463.14 KOO24533.1 - 0.0072 15.5 0.0 0.34 10.0 0.0 2.7 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_10 PF12846.2 KOO24533.1 - 0.014 14.8 0.2 0.031 13.7 0.1 1.6 1 0 0 1 1 1 0 AAA-like domain cobW PF02492.14 KOO24533.1 - 0.021 14.3 0.0 0.038 13.4 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.1 KOO24533.1 - 0.023 14.2 0.3 0.069 12.6 0.2 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.7 KOO24533.1 - 0.042 13.5 0.1 0.042 13.5 0.1 1.8 2 0 0 2 2 2 0 NACHT domain AAA_23 PF13476.1 KOO24533.1 - 0.082 13.2 0.0 0.14 12.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 KOO24533.1 - 0.092 13.5 0.0 0.19 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 KOO24533.1 - 0.12 12.1 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 KOO24533.1 - 0.16 11.9 0.1 0.33 10.9 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_28 PF13521.1 KOO24533.1 - 0.2 11.6 0.2 0.46 10.4 0.1 1.6 1 0 0 1 1 1 0 AAA domain ArgK PF03308.11 KOO24533.1 - 0.2 10.4 0.1 0.36 9.5 0.1 1.3 1 0 0 1 1 1 0 ArgK protein AAA_24 PF13479.1 KOO24533.1 - 0.43 10.1 0.1 0.68 9.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.17 KOO24534.1 - 1.8e-65 220.0 0.9 6.4e-64 215.0 0.7 2.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.14 KOO24534.1 - 1.7e-25 89.2 0.8 1.7e-25 89.2 0.6 3.5 2 1 1 3 3 3 1 Signal peptide binding domain SRP54_N PF02881.14 KOO24534.1 - 1.2e-12 47.6 1.2 3.4e-12 46.2 0.9 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain AAA_33 PF13671.1 KOO24534.1 - 1.6e-08 34.5 0.2 1.6e-07 31.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 KOO24534.1 - 5.3e-06 26.1 2.3 0.00039 20.1 0.0 2.9 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_31 PF13614.1 KOO24534.1 - 1.1e-05 25.4 0.0 0.042 13.7 0.0 2.6 1 1 1 2 2 2 2 AAA domain Zeta_toxin PF06414.7 KOO24534.1 - 8.7e-05 21.6 0.2 0.00032 19.8 0.0 2.0 2 0 0 2 2 2 1 Zeta toxin AAA_17 PF13207.1 KOO24534.1 - 0.0003 21.5 0.0 0.00072 20.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KOO24534.1 - 0.00059 19.9 0.1 0.0029 17.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KOO24534.1 - 0.01 15.8 0.0 0.031 14.2 0.0 1.7 1 1 1 2 2 2 0 AAA ATPase domain CbiA PF01656.18 KOO24534.1 - 0.012 14.9 0.2 0.082 12.2 0.2 2.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain tRNA_lig_kinase PF08303.6 KOO24534.1 - 0.02 14.7 2.0 12 5.7 0.0 3.4 3 0 0 3 3 3 0 tRNA ligase kinase domain APS_kinase PF01583.15 KOO24534.1 - 0.03 13.9 0.1 0.076 12.6 0.0 1.7 2 0 0 2 2 2 0 Adenylylsulphate kinase Fis1_TPR_C PF14853.1 KOO24534.1 - 0.083 12.7 0.2 0.083 12.7 0.1 1.9 2 0 0 2 2 1 0 Fis1 C-terminal tetratricopeptide repeat 6PF2K PF01591.13 KOO24534.1 - 0.089 11.8 0.9 0.32 10.0 0.0 2.2 2 0 0 2 2 2 0 6-phosphofructo-2-kinase AAA PF00004.24 KOO24534.1 - 4.5 7.4 7.4 0.54 10.4 0.3 3.1 4 1 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) Bestrophin PF01062.16 KOO24535.1 - 1.8e-37 128.8 2.6 2.5e-37 128.4 1.8 1.2 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Sulfatase PF00884.18 KOO24536.1 - 7.7e-50 169.8 0.0 1.1e-49 169.3 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.17 KOO24536.1 - 5.2e-09 35.9 0.0 0.00026 20.4 0.0 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DEAD PF00270.24 KOO24538.1 - 3.6e-14 52.6 0.0 4.8e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO24538.1 - 1.4e-08 34.4 0.0 2.1e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO24538.1 - 3.6e-05 23.6 0.0 5.6e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Ribosomal_L2_C PF03947.13 KOO24539.1 - 2.5e-39 134.0 2.6 2.5e-39 134.0 1.8 2.1 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 KOO24539.1 - 4.7e-16 58.5 0.4 1e-15 57.4 0.3 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain TauD PF02668.11 KOO24540.1 - 2.5e-29 102.7 0.0 4.3e-28 98.6 0.0 2.2 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family 2OG-FeII_Oxy PF03171.15 KOO24540.1 - 1.7e-18 66.7 0.0 3.5e-18 65.7 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.1 KOO24540.1 - 0.1 13.1 0.0 0.81 10.2 0.0 2.5 3 0 0 3 3 3 0 2OG-Fe(II) oxygenase superfamily Aa_trans PF01490.13 KOO24541.1 - 9.5e-50 169.2 0.0 3.3e-49 167.4 0.0 1.7 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein SPC12 PF06645.8 KOO24541.1 - 0.26 11.1 2.0 0.92 9.3 0.0 2.6 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) HEAT_2 PF13646.1 KOO24542.1 - 2.8e-12 46.7 0.6 2.1e-05 24.6 0.0 4.5 1 1 4 5 5 5 4 HEAT repeats HEAT PF02985.17 KOO24542.1 - 2.7e-11 42.5 4.5 0.0016 18.3 0.0 5.1 4 0 0 4 4 4 3 HEAT repeat Vac14_Fab1_bd PF12755.2 KOO24542.1 - 1.2e-08 35.2 2.3 0.00047 20.4 0.1 4.0 3 1 2 5 5 5 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.1 KOO24542.1 - 4.2e-07 30.2 25.4 0.0014 19.0 1.0 6.1 4 3 2 6 6 6 2 HEAT-like repeat Cnd1 PF12717.2 KOO24542.1 - 0.0029 17.4 0.0 0.31 10.8 0.0 2.6 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.3 KOO24542.1 - 0.0069 15.7 0.0 0.11 11.8 0.0 2.2 1 1 1 2 2 2 2 CLASP N terminal ParcG PF10274.4 KOO24542.1 - 0.0099 15.7 0.0 0.15 11.9 0.0 2.4 1 1 1 3 3 3 1 Parkin co-regulated protein DUF2454 PF10521.4 KOO24542.1 - 0.011 14.8 0.1 0.029 13.3 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2454) Dopey_N PF04118.9 KOO24542.1 - 0.045 12.5 0.0 0.064 12.0 0.0 1.4 1 0 0 1 1 1 0 Dopey, N-terminal BP28CT PF08146.7 KOO24542.1 - 0.11 12.2 0.0 2.1 8.0 0.0 3.0 2 1 0 2 2 2 0 BP28CT (NUC211) domain Ipi1_N PF12333.3 KOO24542.1 - 0.12 12.3 0.1 0.42 10.6 0.0 1.9 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation Agenet PF05641.7 KOO24544.1 - 0.00033 20.7 1.4 0.25 11.5 0.0 3.5 3 0 0 3 3 3 1 Agenet domain DUF2097 PF09870.4 KOO24544.1 - 0.19 11.8 0.0 0.37 10.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2097) Pro_isomerase PF00160.16 KOO24545.1 - 2.4e-38 131.7 0.0 2.7e-38 131.6 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Exostosin PF03016.10 KOO24548.1 - 2e-46 158.4 0.0 4.7e-31 107.9 0.0 2.3 1 1 1 2 2 2 2 Exostosin family CD36 PF01130.16 KOO24549.1 - 0.0045 15.3 0.0 1.3 7.2 0.0 2.1 2 0 0 2 2 2 2 CD36 family Mito_fiss_reg PF05308.6 KOO24550.1 - 0.14 11.5 1.0 0.19 11.0 0.7 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator zf-C4_ClpX PF06689.8 KOO24551.1 - 0.07 12.6 0.6 0.14 11.7 0.4 1.5 1 0 0 1 1 1 0 ClpX C4-type zinc finger DEAD PF00270.24 KOO24552.1 - 5e-35 120.4 0.2 7.6e-34 116.6 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO24552.1 - 9.3e-22 76.6 0.0 2e-21 75.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C_2 PF13307.1 KOO24552.1 - 0.00029 20.8 0.0 0.0011 18.8 0.0 2.0 3 0 0 3 3 3 1 Helicase C-terminal domain AAA_19 PF13245.1 KOO24552.1 - 0.00044 19.9 0.0 0.0055 16.4 0.0 2.4 2 0 0 2 2 2 1 Part of AAA domain ResIII PF04851.10 KOO24552.1 - 0.0027 17.5 0.0 0.0087 15.9 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit TFIID_30kDa PF03540.8 KOO24552.1 - 0.0086 15.8 0.0 0.022 14.6 0.0 1.7 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit DUF1253 PF06862.7 KOO24552.1 - 0.032 12.6 0.0 4.2 5.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1253) CDC27 PF09507.5 KOO24553.1 - 0.3 10.2 13.5 0.54 9.4 9.4 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 TPT PF03151.11 KOO24554.1 - 6.2e-21 74.6 1.7 6.2e-21 74.6 1.2 2.2 3 0 0 3 3 3 1 Triose-phosphate Transporter family EamA PF00892.15 KOO24554.1 - 4.4e-08 33.2 14.1 2.4e-07 30.8 3.5 2.7 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.6 KOO24554.1 - 0.00024 20.1 3.8 0.023 13.6 0.8 2.3 2 0 0 2 2 2 2 UAA transporter family DUF3413 PF11893.3 KOO24554.1 - 0.54 9.0 2.9 0.21 10.4 0.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3413) ATP_synt_I PF03899.10 KOO24554.1 - 0.6 10.3 9.8 1.2 9.2 2.2 2.7 2 0 0 2 2 2 0 ATP synthase I chain Asp PF00026.18 KOO24556.1 - 7.4e-11 41.8 0.0 1.4e-10 40.9 0.0 1.4 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.1 KOO24556.1 - 0.00037 20.9 0.0 0.5 10.8 0.0 2.4 2 0 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.1 KOO24556.1 - 0.043 13.3 0.0 0.14 11.7 0.0 1.8 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal GCV_T PF01571.16 KOO24557.1 - 3.9e-62 209.3 0.0 5.1e-62 208.9 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 KOO24557.1 - 1.3e-23 82.8 0.2 3.3e-23 81.5 0.1 1.8 2 0 0 2 2 2 1 Glycine cleavage T-protein C-terminal barrel domain SoxG PF04268.7 KOO24557.1 - 0.00011 22.0 0.0 0.00019 21.3 0.0 1.4 1 0 0 1 1 1 1 Sarcosine oxidase, gamma subunit family SUI1 PF01253.17 KOO24557.1 - 0.047 13.5 0.0 0.096 12.4 0.0 1.5 1 0 0 1 1 1 0 Translation initiation factor SUI1 PHO4 PF01384.15 KOO24558.1 - 5.4e-84 281.6 22.6 6.4e-84 281.3 15.7 1.0 1 0 0 1 1 1 1 Phosphate transporter family DUF917 PF06032.7 KOO24559.1 - 0.037 12.5 0.1 0.068 11.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF917) Telomere_Sde2 PF13019.1 KOO24559.1 - 0.057 13.1 0.2 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 Telomere stability and silencing IGPS PF00218.16 KOO24560.1 - 2.4e-86 288.9 0.1 5.6e-86 287.7 0.0 1.6 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase PRAI PF00697.17 KOO24560.1 - 9.7e-51 172.1 0.2 4.1e-47 160.2 0.0 2.2 2 0 0 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase His_biosynth PF00977.16 KOO24560.1 - 0.12 11.5 0.5 2.1 7.5 0.0 2.5 2 0 0 2 2 2 0 Histidine biosynthesis protein HATPase_c PF02518.21 KOO24561.1 - 1.6e-16 60.0 0.3 3e-16 59.1 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 KOO24561.1 - 6.3e-15 55.1 0.0 1.3e-14 54.1 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c_3 PF13589.1 KOO24561.1 - 0.0036 16.9 0.0 0.0062 16.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Arm PF00514.18 KOO24562.1 - 3.7e-237 759.3 201.9 4.5e-09 35.7 0.2 63.2 65 0 0 65 65 65 48 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO24562.1 - 1e-35 121.8 267.7 5.1e-06 26.6 0.9 32.4 10 5 21 34 34 34 24 HEAT repeats EF-hand_6 PF13405.1 KOO24562.1 - 2.3e-32 107.9 5.7 0.00016 21.3 0.0 9.8 10 0 0 10 10 10 6 EF-hand domain EF-hand_1 PF00036.27 KOO24562.1 - 1.2e-30 102.3 4.9 8.6e-05 21.5 0.1 8.2 8 0 0 8 8 8 6 EF hand EF-hand_7 PF13499.1 KOO24562.1 - 3.3e-29 100.7 2.5 4.1e-09 36.4 0.0 5.5 6 0 0 6 6 5 4 EF-hand domain pair V-ATPase_H_N PF03224.9 KOO24562.1 - 4.9e-28 98.1 9.7 0.00012 21.3 0.0 15.0 5 4 5 12 12 12 5 V-ATPase subunit H EF-hand_8 PF13833.1 KOO24562.1 - 5.9e-24 83.4 1.1 2e-08 33.6 0.0 6.0 5 1 1 6 6 5 4 EF-hand domain pair Arm_2 PF04826.8 KOO24562.1 - 7.3e-24 84.2 21.6 0.013 14.6 0.2 19.4 10 5 10 23 23 23 6 Armadillo-like EF-hand_5 PF13202.1 KOO24562.1 - 3.1e-20 70.5 13.3 1.9e-05 23.7 0.2 7.2 8 0 0 8 8 8 4 EF hand Atx10homo_assoc PF09759.4 KOO24562.1 - 9.9e-16 57.3 16.2 0.014 15.0 0.2 12.0 12 0 0 12 12 12 2 Spinocerebellar ataxia type 10 protein domain ABC1 PF03109.11 KOO24562.1 - 4.3e-13 49.2 0.0 1.3e-12 47.7 0.0 1.7 1 0 0 1 1 1 1 ABC1 family KAP PF05804.7 KOO24562.1 - 9.6e-07 27.1 0.0 0.94 7.3 0.0 5.1 4 1 0 5 5 5 3 Kinesin-associated protein (KAP) Adaptin_N PF01602.15 KOO24562.1 - 5.5e-06 24.9 30.9 0.74 8.0 0.1 11.5 9 4 3 13 13 13 4 Adaptin N terminal region HEAT PF02985.17 KOO24562.1 - 0.00029 20.6 77.8 5.8 7.2 0.1 26.3 28 0 0 28 28 28 2 HEAT repeat RYDR_ITPR PF01365.16 KOO24562.1 - 0.016 14.4 0.1 0.12 11.6 0.0 2.5 1 0 0 1 1 1 0 RIH domain TIG PF01833.19 KOO24563.1 - 6.9e-53 176.5 31.9 1.5e-05 24.9 1.2 18.3 17 2 0 17 17 17 14 IPT/TIG domain fn3 PF00041.16 KOO24563.1 - 5e-10 39.3 0.0 1.2e-09 38.1 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III domain La PF05383.12 KOO24564.1 - 7.2e-13 48.1 0.0 1.6e-12 47.0 0.0 1.6 1 0 0 1 1 1 1 La domain RRM_3 PF08777.6 KOO24564.1 - 1.2e-08 34.7 0.1 6.2e-08 32.4 0.0 2.3 2 0 0 2 2 2 1 RNA binding motif RRM_6 PF14259.1 KOO24564.1 - 2e-05 24.4 0.0 0.0025 17.7 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO24564.1 - 3.6e-05 23.5 0.0 0.00042 20.1 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAZ PF02170.17 KOO24564.1 - 0.0013 18.0 0.0 0.0026 17.0 0.0 1.4 1 0 0 1 1 1 1 PAZ domain RRM_1 PF00076.17 KOO24564.1 - 0.014 15.0 0.0 0.034 13.7 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EF-hand_1 PF00036.27 KOO24565.1 - 5.4e-07 28.4 0.6 0.11 11.8 0.0 3.4 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 KOO24565.1 - 7.4e-07 28.5 1.8 0.49 10.4 0.1 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.1 KOO24565.1 - 6.4e-06 25.6 0.1 0.0046 16.5 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO24565.1 - 0.00011 21.4 3.5 2.2 7.8 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.1 KOO24565.1 - 0.00076 19.5 1.1 0.91 9.7 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair Asp-B-Hydro_N PF05279.6 KOO24565.1 - 0.003 17.4 0.0 0.0063 16.3 0.0 1.6 1 0 0 1 1 1 1 Aspartyl beta-hydroxylase N-terminal region HisKA_3 PF07730.8 KOO24565.1 - 0.18 12.1 9.4 0.096 13.0 0.5 2.9 3 0 0 3 3 3 0 Histidine kinase TFIIA PF03153.8 KOO24565.1 - 2.5 7.9 13.1 2 8.1 8.0 1.5 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit HEAT PF02985.17 KOO24567.1 - 2.2e-27 92.6 26.6 0.013 15.5 0.0 11.6 10 1 1 11 11 11 8 HEAT repeat HEAT_2 PF13646.1 KOO24567.1 - 1.3e-24 86.2 30.1 3e-06 27.4 1.3 7.7 2 1 5 7 7 7 6 HEAT repeats HEAT_EZ PF13513.1 KOO24567.1 - 3.3e-17 62.3 43.0 0.00035 20.9 0.1 9.1 5 4 6 11 11 11 8 HEAT-like repeat Cnd1 PF12717.2 KOO24567.1 - 3.1e-12 46.6 4.7 0.00032 20.5 0.0 6.0 4 2 1 6 6 6 2 non-SMC mitotic condensation complex subunit 1 ART PF01129.13 KOO24567.1 - 5e-08 32.3 0.0 8.2e-08 31.6 0.0 1.2 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Adaptin_N PF01602.15 KOO24567.1 - 1e-06 27.4 1.9 0.0002 19.8 0.6 3.5 2 2 0 2 2 2 1 Adaptin N terminal region ADPrib_exo_Tox PF03496.9 KOO24567.1 - 1.2e-05 24.5 0.0 2.1e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Vac14_Fab1_bd PF12755.2 KOO24567.1 - 0.00043 20.6 1.0 5 7.5 0.0 5.5 4 3 1 5 5 5 1 Vacuolar 14 Fab1-binding region Dimer_Tnp_hAT PF05699.9 KOO24567.1 - 0.0058 16.2 0.0 0.021 14.4 0.0 1.9 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region Arm PF00514.18 KOO24567.1 - 0.19 11.5 16.5 3.9 7.4 0.1 7.3 8 2 2 10 10 9 0 Armadillo/beta-catenin-like repeat Nipped-B_C PF12830.2 KOO24567.1 - 0.34 10.5 2.1 9.6 5.8 0.0 3.5 4 0 0 4 4 4 0 Sister chromatid cohesion C-terminus CLASP_N PF12348.3 KOO24567.1 - 0.59 9.4 3.6 6.2 6.1 0.1 4.0 3 2 2 5 5 5 0 CLASP N terminal HEAT_PBS PF03130.11 KOO24567.1 - 1.1 9.9 21.8 6.9 7.4 0.0 8.3 8 2 1 9 9 7 0 PBS lyase HEAT-like repeat DUF4042 PF13251.1 KOO24567.1 - 5.3 6.4 12.8 4.8 6.6 0.0 5.5 5 3 2 7 7 7 0 Domain of unknown function (DUF4042) Hex_IIIa PF02455.11 KOO24569.1 - 0.98 8.0 11.2 1.1 7.8 7.8 1.0 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) Zip PF02535.17 KOO24569.1 - 1.5 7.7 9.1 1.7 7.5 6.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter TFIIF_alpha PF05793.7 KOO24569.1 - 2.6 6.3 33.5 3 6.1 23.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DNA_pol_viral_N PF00242.12 KOO24569.1 - 3.4 6.5 13.9 4.1 6.3 9.6 1.0 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain DUF572 PF04502.8 KOO24569.1 - 4.2 6.4 23.3 5.1 6.2 16.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) KOW PF00467.24 KOO24570.1 - 0.048 13.3 0.2 3.9 7.3 0.0 2.6 2 0 0 2 2 2 0 KOW motif Prenyltransf PF01255.14 KOO24571.1 - 1.3e-43 148.7 0.0 2e-43 148.0 0.0 1.3 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Dynein_light PF01221.13 KOO24571.1 - 3.4e-34 116.7 2.8 3.2e-33 113.5 1.7 2.1 2 0 0 2 2 2 1 Dynein light chain type 1 DUF2110 PF09883.4 KOO24571.1 - 0.073 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2110) DUF4225 PF13988.1 KOO24572.1 - 0.075 12.4 1.6 0.12 11.8 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4225) WW PF00397.21 KOO24572.1 - 0.42 10.5 5.7 0.34 10.8 1.9 2.4 2 0 0 2 2 2 0 WW domain Ion_trans PF00520.26 KOO24573.1 - 4.7e-15 55.3 6.2 1.5e-13 50.4 4.3 2.4 1 1 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO24573.1 - 1.7e-11 43.6 2.8 5.9e-11 41.9 1.9 1.9 1 0 0 1 1 1 1 Ion channel cNMP_binding PF00027.24 KOO24573.1 - 1.2e-09 37.8 0.0 6.4e-09 35.5 0.0 2.2 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain Acyl-CoA_dh_C PF12806.2 KOO24573.1 - 0.013 15.3 2.9 0.063 13.1 0.1 2.8 2 1 1 3 3 3 0 Acetyl-CoA dehydrogenase C-terminal like DUF4546 PF15079.1 KOO24573.1 - 0.04 13.0 1.8 0.05 12.7 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4546) Ion_trans_N PF08412.5 KOO24573.1 - 0.047 12.9 0.2 0.38 10.0 0.0 2.4 2 0 0 2 2 2 0 Ion transport protein N-terminal WRW PF10206.4 KOO24573.1 - 0.062 13.3 1.5 0.22 11.6 0.1 2.3 2 0 0 2 2 2 0 Mitochondrial F1F0-ATP synthase, subunit f CHAD PF05235.9 KOO24574.1 - 0.012 15.2 0.1 0.013 15.0 0.1 1.1 1 0 0 1 1 1 0 CHAD domain Pam16 PF03656.8 KOO24575.1 - 3.9e-10 39.6 0.0 5e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 Pam16 DnaJ PF00226.26 KOO24575.1 - 0.022 14.4 0.0 0.034 13.8 0.0 1.2 1 0 0 1 1 1 0 DnaJ domain DUF155 PF02582.9 KOO24576.1 - 2e-42 145.0 0.1 2.6e-42 144.6 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 5_nucleotid PF05761.9 KOO24577.1 - 1.6e-99 333.4 0.0 1.8e-99 333.3 0.0 1.0 1 0 0 1 1 1 1 5' nucleotidase family HAD_2 PF13419.1 KOO24577.1 - 0.0026 17.9 0.0 0.23 11.6 0.0 2.5 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase SH3_9 PF14604.1 KOO24578.1 - 2.3e-11 43.1 0.0 5.1e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 KOO24578.1 - 3.8e-11 42.3 0.4 1.9e-10 40.0 0.1 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.23 KOO24578.1 - 4.6e-09 35.5 0.0 9.7e-09 34.4 0.0 1.6 1 0 0 1 1 1 1 SH3 domain FAD_binding_3 PF01494.14 KOO24578.1 - 0.00032 19.8 0.1 0.0007 18.7 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 KOO24578.1 - 0.0051 15.7 0.2 0.011 14.7 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.16 KOO24578.1 - 0.0059 16.2 0.4 0.061 12.8 0.1 2.5 3 0 0 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.9 KOO24578.1 - 0.0099 14.3 0.0 0.016 13.7 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.9 KOO24578.1 - 0.011 15.6 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 KOO24578.1 - 0.013 14.3 0.1 0.032 13.0 0.0 1.6 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.22 KOO24578.1 - 0.023 15.0 0.2 0.045 14.1 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 KOO24578.1 - 0.044 13.8 0.0 0.15 12.0 0.0 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.1 KOO24578.1 - 0.087 13.0 0.0 0.23 11.7 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding DUF1843 PF08898.5 KOO24579.1 - 0.00091 19.2 5.2 0.042 13.8 0.4 3.0 2 0 0 2 2 2 2 Domain of unknown function (DUF1843) IQ PF00612.22 KOO24579.1 - 0.001 18.5 1.4 0.003 17.0 0.9 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif KIAA1430 PF13879.1 KOO24580.1 - 4.1e-12 46.3 2.8 3.4e-11 43.4 2.0 2.2 1 1 0 1 1 1 1 KIAA1430 homologue Kelch_3 PF13415.1 KOO24581.1 - 2.2e-19 69.0 0.5 8.5e-07 28.9 0.0 3.5 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KOO24581.1 - 3.5e-19 68.3 0.3 1.3e-05 24.8 0.0 4.1 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO24581.1 - 3.1e-17 62.1 0.1 4.4e-05 23.3 0.0 4.3 4 0 0 4 4 4 4 Kelch motif Kelch_6 PF13964.1 KOO24581.1 - 1.7e-13 50.1 0.0 0.0011 19.0 0.0 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.20 KOO24581.1 - 8.9e-13 47.5 0.0 0.00054 19.4 0.0 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.10 KOO24581.1 - 1.4e-10 40.4 0.2 0.034 13.9 0.0 3.8 4 0 0 4 4 4 3 Kelch motif PsbQ PF05757.6 KOO24582.1 - 0.096 12.0 1.9 2.2 7.6 0.1 2.4 2 0 0 2 2 2 0 Oxygen evolving enhancer protein 3 (PsbQ) EF-hand_1 PF00036.27 KOO24583.1 - 2.2e-43 142.2 27.5 1.5e-05 23.9 1.1 8.5 8 0 0 8 8 8 8 EF hand EF-hand_6 PF13405.1 KOO24583.1 - 7.5e-38 125.0 28.4 4.7e-05 22.9 0.0 8.9 8 0 0 8 8 8 8 EF-hand domain EF-hand_7 PF13499.1 KOO24583.1 - 7.3e-36 122.1 21.2 1.2e-09 38.1 0.1 6.2 4 1 1 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.1 KOO24583.1 - 1e-31 106.8 28.4 0.00027 20.1 0.0 8.4 8 0 0 8 8 8 8 EF hand EF-hand_8 PF13833.1 KOO24583.1 - 9.3e-26 89.2 23.5 1.3e-07 31.1 0.0 7.3 6 1 1 7 7 7 6 EF-hand domain pair EF-hand_4 PF12763.2 KOO24583.1 - 2.2e-05 24.1 15.5 0.037 13.7 0.3 4.6 5 2 1 6 6 6 3 Cytoskeletal-regulatory complex EF hand IQ PF00612.22 KOO24583.1 - 0.00022 20.6 0.1 0.00062 19.1 0.1 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif EF-hand_9 PF14658.1 KOO24583.1 - 0.036 13.9 0.6 49 3.9 0.0 4.3 4 0 0 4 4 4 0 EF-hand domain Methyltransf_3 PF01596.12 KOO24583.1 - 0.23 10.4 1.2 0.26 10.2 0.0 1.6 2 0 0 2 2 2 0 O-methyltransferase Lipase_GDSL_2 PF13472.1 KOO24584.1 - 1.5e-05 25.1 0.1 3.7e-05 23.9 0.1 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family PC-Esterase PF13839.1 KOO24584.1 - 0.00027 20.8 0.0 0.002 17.9 0.0 2.2 1 1 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p Amino_oxidase PF01593.19 KOO24585.1 - 4.1e-35 121.7 0.4 8e-35 120.7 0.3 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Tudor-knot PF11717.3 KOO24585.1 - 0.065 12.9 0.2 0.17 11.6 0.1 1.7 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain DENN PF02141.16 KOO24587.1 - 5.5e-14 52.3 0.0 8.3e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.13 KOO24587.1 - 0.022 14.6 0.0 0.045 13.7 0.0 1.4 1 0 0 1 1 1 0 uDENN domain RPN7 PF10602.4 KOO24590.1 - 3.9e-59 199.0 0.8 5.7e-59 198.4 0.6 1.3 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.22 KOO24590.1 - 2.4e-15 56.7 0.5 9.1e-15 54.8 0.1 2.1 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.12 KOO24590.1 - 0.0023 17.7 1.1 0.079 12.9 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOO24590.1 - 0.0031 17.1 1.6 0.26 10.9 0.0 2.9 3 0 0 3 3 3 1 TPR repeat TPR_16 PF13432.1 KOO24590.1 - 0.0037 17.8 3.7 0.27 11.9 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat SNAP PF14938.1 KOO24590.1 - 0.017 14.2 1.1 0.041 13.0 0.7 1.6 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP TPR_1 PF00515.23 KOO24590.1 - 0.021 14.3 0.9 0.049 13.2 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Sugarporin_N PF11471.3 KOO24590.1 - 0.12 11.9 0.1 0.12 11.9 0.1 1.9 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension UPF0061 PF02696.9 KOO24591.1 - 7.4e-70 235.6 0.0 9.4e-70 235.2 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family GDA1_CD39 PF01150.12 KOO24592.1 - 4.1e-42 144.1 0.0 5.5e-42 143.7 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family MadM PF03818.8 KOO24592.1 - 0.022 14.2 0.5 0.044 13.3 0.3 1.4 1 0 0 1 1 1 0 Malonate/sodium symporter MadM subunit DUF563 PF04577.9 KOO24594.1 - 1.6e-15 57.6 0.0 4e-15 56.2 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF563) LRR_6 PF13516.1 KOO24594.1 - 1.3e-08 33.9 2.0 2.1 8.6 0.0 6.8 7 0 0 7 7 7 2 Leucine Rich repeat HATPase_c_3 PF13589.1 KOO24594.1 - 7.1e-08 32.1 0.0 2.1e-07 30.6 0.0 1.7 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LRR_4 PF12799.2 KOO24594.1 - 4.4e-06 26.1 0.0 1.4 8.6 0.0 4.1 2 2 0 3 3 3 2 Leucine Rich repeats (2 copies) AP2 PF00847.15 KOO24594.1 - 0.002 18.2 0.4 0.012 15.7 0.2 2.3 2 0 0 2 2 2 1 AP2 domain HATPase_c PF02518.21 KOO24594.1 - 0.16 11.6 0.0 0.45 10.2 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mto2_bdg PF12808.2 KOO24596.1 - 0.099 12.7 0.3 72 3.5 0.0 3.7 4 0 0 4 4 4 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Glyco_transf_8 PF01501.15 KOO24597.1 - 0.042 13.1 0.0 0.05 12.9 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 8 TelA PF05816.6 KOO24598.1 - 0.027 13.1 0.3 0.03 13.0 0.2 1.1 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) PsbQ PF05757.6 KOO24598.1 - 0.031 13.6 0.5 0.036 13.4 0.4 1.1 1 0 0 1 1 1 0 Oxygen evolving enhancer protein 3 (PsbQ) adh_short PF00106.20 KOO24599.1 - 6.3e-22 78.2 0.5 3.5e-21 75.8 0.1 2.0 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 KOO24599.1 - 3e-07 30.2 0.1 4.9e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 KR domain Lactamase_B PF00753.22 KOO24600.1 - 1.9e-14 53.8 0.0 2e-14 53.6 0.0 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 KOO24600.1 - 2.8e-10 40.0 0.0 3.2e-10 39.8 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.1 KOO24600.1 - 1.5e-05 24.3 0.0 2e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 tRNase Z endonuclease SipA PF09052.5 KOO24601.1 - 1.1 7.5 2.7 1.6 7.0 1.9 1.1 1 0 0 1 1 1 0 Salmonella invasion protein A Ras PF00071.17 KOO24602.1 - 1.5e-61 206.5 0.3 1.7e-61 206.3 0.2 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO24602.1 - 3.4e-20 72.7 0.0 4.9e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO24602.1 - 1.1e-15 57.2 0.1 1.4e-15 56.9 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KOO24602.1 - 1.3e-07 31.0 0.1 1.7e-07 30.6 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KOO24602.1 - 1.5e-05 24.4 0.1 2.3e-05 23.8 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOO24602.1 - 0.00022 21.1 0.2 0.00043 20.2 0.1 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 KOO24602.1 - 0.00087 18.5 0.1 0.0055 15.9 0.1 2.0 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 KOO24602.1 - 0.0061 16.6 0.0 0.017 15.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 KOO24602.1 - 0.0089 15.5 0.0 0.07 12.6 0.0 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.1 KOO24602.1 - 0.0092 15.9 0.1 0.019 14.9 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.9 KOO24602.1 - 0.021 14.5 0.0 0.038 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) MCM PF00493.18 KOO24602.1 - 0.067 11.9 0.0 0.12 11.1 0.0 1.3 1 0 0 1 1 1 0 MCM2/3/5 family SRPRB PF09439.5 KOO24602.1 - 0.09 11.9 0.1 0.12 11.5 0.1 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Sod_Cu PF00080.15 KOO24604.1 - 8.1e-45 152.4 1.3 9.8e-45 152.1 0.9 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Pkinase PF00069.20 KOO24605.1 - 1.4e-62 211.2 0.0 1.7e-62 210.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO24605.1 - 4.1e-28 98.1 0.0 6.1e-28 97.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO24605.1 - 0.00013 21.0 0.0 0.0011 17.9 0.0 2.4 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.9 KOO24605.1 - 0.21 10.6 0.1 0.57 9.2 0.1 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family AOX PF01786.12 KOO24607.1 - 1.2e-28 99.9 0.0 1.9e-28 99.2 0.0 1.3 1 0 0 1 1 1 1 Alternative oxidase Dynamin_M PF01031.15 KOO24608.1 - 1.4e-74 250.5 0.0 2e-74 250.0 0.0 1.2 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.18 KOO24608.1 - 4.7e-50 169.6 0.0 7.4e-50 169.0 0.0 1.3 1 0 0 1 1 1 1 Dynamin family GED PF02212.13 KOO24608.1 - 1.3e-27 95.5 1.1 2.1e-27 94.8 0.8 1.4 1 0 0 1 1 1 1 Dynamin GTPase effector domain Miro PF08477.8 KOO24608.1 - 0.012 16.1 0.0 0.024 15.1 0.0 1.5 1 0 0 1 1 1 0 Miro-like protein MMR_HSR1 PF01926.18 KOO24608.1 - 0.022 14.6 0.0 0.12 12.3 0.0 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase Nucleotid_trans PF03407.11 KOO24610.1 - 2.7e-20 73.0 0.0 4.2e-20 72.4 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Lipase_GDSL_2 PF13472.1 KOO24611.1 - 4.4e-10 39.9 0.7 1.2e-09 38.6 0.5 1.7 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Sugar_tr PF00083.19 KOO24612.1 - 3.9e-15 55.3 9.7 3.9e-15 55.3 6.8 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOO24612.1 - 1.1e-14 54.0 20.2 1.4e-14 53.5 14.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily ACT_5 PF13710.1 KOO24612.1 - 0.099 12.4 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 ACT domain DUF1681 PF07933.9 KOO24614.1 - 3.8e-47 159.8 0.0 4.9e-47 159.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) Pkinase PF00069.20 KOO24616.1 - 7.9e-63 212.0 0.0 1.1e-62 211.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO24616.1 - 1.8e-33 115.6 0.0 2.7e-33 115.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.27 KOO24616.1 - 3.3e-33 110.4 4.9 1.6e-08 33.2 0.0 5.0 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.1 KOO24616.1 - 6.8e-30 103.0 0.0 6.3e-16 58.2 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO24616.1 - 4.6e-29 97.6 0.6 1.4e-07 30.8 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO24616.1 - 1.5e-23 80.9 6.2 9.9e-07 27.8 0.1 4.4 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO24616.1 - 1.6e-23 82.0 3.0 4.5e-13 48.5 0.0 4.3 2 2 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO24616.1 - 1.2e-08 34.9 0.0 0.0012 18.8 0.0 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO24616.1 - 1.1e-07 31.5 0.1 0.063 13.0 0.0 3.6 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Kinase-like PF14531.1 KOO24616.1 - 1.5e-05 24.1 0.0 2.3e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOO24616.1 - 0.00068 18.7 0.0 0.0011 18.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_9 PF14658.1 KOO24616.1 - 0.0019 18.0 0.0 1.2 9.0 0.0 3.4 2 1 0 2 2 2 1 EF-hand domain p25-alpha PF05517.7 KOO24616.1 - 0.0066 16.7 0.1 0.03 14.5 0.0 1.9 1 1 1 2 2 2 1 p25-alpha ATPgrasp_ST PF14397.1 KOO24616.1 - 0.02 13.9 0.0 0.031 13.3 0.0 1.2 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp TerB PF05099.8 KOO24616.1 - 0.026 14.2 0.4 1.4 8.5 0.0 2.8 2 1 1 3 3 3 0 Tellurite resistance protein TerB APH PF01636.18 KOO24616.1 - 0.055 13.1 0.4 0.1 12.3 0.1 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 KOO24616.1 - 0.1 11.9 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pox_ser-thr_kin PF05445.6 KOO24616.1 - 0.22 10.2 0.0 0.33 9.7 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Arm PF00514.18 KOO24618.1 - 4.9e-08 32.4 21.4 0.027 14.3 0.3 7.3 7 0 0 7 7 7 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO24618.1 - 2.8e-05 24.3 9.5 0.00088 19.5 0.4 3.7 2 1 1 3 3 3 2 HEAT repeats HEAT_EZ PF13513.1 KOO24618.1 - 0.0034 17.8 1.9 0.0034 17.8 1.3 4.8 4 2 0 5 5 5 1 HEAT-like repeat Arm_2 PF04826.8 KOO24618.1 - 0.032 13.3 0.0 1.1 8.2 0.0 2.6 2 1 1 3 3 3 0 Armadillo-like DUF383 PF04063.9 KOO24618.1 - 0.13 11.7 0.0 25 4.3 0.0 3.0 2 2 1 3 3 3 0 Domain of unknown function (DUF383) HEAT PF02985.17 KOO24618.1 - 2.5 8.4 7.3 0.73 10.0 0.1 3.9 4 0 0 4 4 4 0 HEAT repeat SecA_DEAD PF07517.9 KOO24619.1 - 2.6e-09 36.7 0.3 9.2e-09 34.9 0.0 2.1 2 0 0 2 2 2 1 SecA DEAD-like domain MMR_HSR1 PF01926.18 KOO24619.1 - 0.00035 20.5 0.1 0.001 19.0 0.1 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Helicase_C PF00271.26 KOO24619.1 - 0.00036 20.3 0.0 0.00088 19.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF258 PF03193.11 KOO24619.1 - 0.0016 17.6 0.0 0.0038 16.4 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 KOO24619.1 - 0.02 15.1 0.0 0.096 12.9 0.0 2.2 1 0 0 1 1 1 0 ABC transporter Septin PF00735.13 KOO24619.1 - 0.023 13.7 0.0 0.044 12.7 0.0 1.4 1 0 0 1 1 1 0 Septin PAE PF03283.8 KOO24620.1 - 2.4e-37 128.4 0.0 2.8e-37 128.2 0.0 1.0 1 0 0 1 1 1 1 Pectinacetylesterase Ion_trans PF00520.26 KOO24621.1 - 1.4e-28 99.5 8.9 1.8e-28 99.1 6.1 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO24621.1 - 4e-13 48.8 3.0 4e-13 48.8 2.1 2.2 2 1 0 3 3 3 1 Ion channel OAD_gamma PF04277.8 KOO24621.1 - 0.035 14.4 1.2 0.53 10.6 0.1 2.6 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF4605 PF15378.1 KOO24621.1 - 0.11 12.2 2.5 0.25 11.0 1.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4605) DUF2614 PF11023.3 KOO24621.1 - 1.1 9.1 5.0 0.26 11.0 0.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2614) DnaJ PF00226.26 KOO24622.1 - 1.3e-19 69.6 0.1 2.1e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain fn3 PF00041.16 KOO24622.1 - 1.6e-06 28.1 0.0 4.8e-06 26.6 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III domain PDZ PF00595.19 KOO24622.1 - 1.3e-05 25.2 0.0 2.7e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO24622.1 - 0.0027 17.5 0.0 0.006 16.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain TPR_11 PF13414.1 KOO24623.1 - 7.9e-08 31.8 2.4 2e-07 30.5 0.6 2.4 2 1 0 2 2 2 1 TPR repeat START PF01852.14 KOO24623.1 - 9.3e-05 21.8 0.1 0.00036 19.9 0.0 2.0 2 1 0 2 2 2 1 START domain TPR_1 PF00515.23 KOO24623.1 - 0.00088 18.7 4.8 0.061 12.9 0.2 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO24623.1 - 0.0011 18.7 6.5 0.018 14.8 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO24623.1 - 0.0019 17.8 0.1 1.5 8.7 0.0 3.3 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO24623.1 - 0.0075 16.8 2.3 5.6 7.8 0.0 4.1 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO24623.1 - 0.0076 15.9 0.2 4.9 7.1 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO24623.1 - 0.015 15.9 0.0 0.13 12.9 0.0 2.6 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO24623.1 - 0.032 14.0 0.0 2.9 7.7 0.0 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat UMPH-1 PF05822.7 KOO24623.1 - 0.21 10.8 0.0 0.56 9.4 0.0 1.6 2 0 0 2 2 2 0 Pyrimidine 5'-nucleotidase (UMPH-1) LrgB PF04172.11 KOO24624.1 - 5.3e-29 100.9 13.6 1.1e-28 99.9 9.4 1.6 1 1 0 1 1 1 1 LrgB-like family LrgA PF03788.9 KOO24624.1 - 0.27 10.9 19.4 0.4 10.4 2.7 3.6 2 1 1 3 3 3 0 LrgA family EF-hand_1 PF00036.27 KOO24625.1 - 1.4e-09 36.5 0.0 0.0039 16.3 0.0 3.7 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.1 KOO24625.1 - 9.6e-08 31.0 0.1 0.045 13.1 0.0 3.9 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO24625.1 - 3.1e-07 29.6 0.1 0.0073 16.1 0.0 3.9 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.1 KOO24625.1 - 5.8e-07 29.0 0.2 0.017 14.7 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.1 KOO24625.1 - 7.5e-07 29.2 0.0 0.031 14.3 0.0 3.4 2 1 0 2 2 2 2 EF-hand domain pair V_ATPase_I PF01496.14 KOO24625.1 - 3.4 5.3 4.6 5.9 4.6 3.2 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EF-hand_6 PF13405.1 KOO24626.1 - 5.7e-14 50.6 0.3 7.1e-06 25.4 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO24626.1 - 2.4e-13 48.2 0.5 2.3e-05 23.3 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO24626.1 - 1.1e-11 44.6 0.2 3.9e-11 42.9 0.1 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO24626.1 - 1.4e-10 40.5 0.8 2.6e-07 30.1 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO24626.1 - 3.6e-08 32.3 0.3 0.0015 17.8 0.0 2.8 2 0 0 2 2 2 2 EF hand HR1 PF02185.11 KOO24626.1 - 4.3e-06 26.3 2.6 4.3e-06 26.3 1.8 4.0 3 1 0 4 4 4 1 Hr1 repeat EF-hand_10 PF14788.1 KOO24626.1 - 0.013 15.1 0.2 0.041 13.5 0.1 1.9 1 1 1 2 2 2 0 EF hand BRE1 PF08647.6 KOO24626.1 - 0.029 14.3 22.6 0.032 14.1 6.2 3.0 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase GATase_5 PF13507.1 KOO24626.1 - 0.039 12.8 2.6 4.4 6.1 1.8 2.2 1 1 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain HYLS1_C PF15311.1 KOO24626.1 - 0.21 11.8 4.7 0.54 10.5 3.2 1.8 1 0 0 1 1 1 0 Hydrolethalus syndrome protein 1 C-terminus DUF4559 PF15112.1 KOO24626.1 - 0.49 9.4 10.1 0.94 8.5 7.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) RNA_pol_Rpb1_5 PF04998.12 KOO24626.1 - 1 8.5 0.0 1 8.5 0.0 2.5 2 1 0 2 2 2 0 RNA polymerase Rpb1, domain 5 APG6 PF04111.7 KOO24626.1 - 1.6 7.6 35.1 0.11 11.4 6.4 2.5 2 1 1 3 3 3 0 Autophagy protein Apg6 DUF1664 PF07889.7 KOO24626.1 - 3.3 7.5 11.8 0.34 10.7 1.6 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF3138 PF11336.3 KOO24626.1 - 6.7 4.7 14.8 37 2.3 10.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) DUF3365 PF11845.3 KOO24626.1 - 7 6.4 11.9 8.9 6.1 7.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3365) NPV_P10 PF05531.7 KOO24626.1 - 8.5 6.7 10.4 62 3.9 1.5 3.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.5 KOO24626.1 - 8.8 6.4 13.2 8.1 6.5 5.0 3.0 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.4 KOO24626.1 - 9.2 6.4 13.3 0.62 10.2 2.1 3.4 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Ribosomal_S21e PF01249.13 KOO24627.1 - 2.1e-34 117.3 0.0 2.6e-34 116.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S21e Methyltransf_11 PF08241.7 KOO24628.1 - 2.5e-24 85.6 0.0 4.2e-24 84.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO24628.1 - 4.1e-22 78.4 0.0 5.6e-22 77.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO24628.1 - 9.1e-21 74.2 0.0 1.6e-20 73.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO24628.1 - 4.7e-17 62.2 0.0 9.1e-17 61.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO24628.1 - 2.8e-15 56.8 0.0 5.1e-15 56.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 KOO24628.1 - 2e-13 50.0 0.0 2.6e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 KOO24628.1 - 2.5e-12 46.3 0.0 4e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 KOO24628.1 - 6.3e-12 45.7 0.0 1.1e-11 45.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO24628.1 - 1e-09 38.3 0.0 2.7e-09 37.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.11 KOO24628.1 - 5.2e-08 31.6 0.0 8.1e-08 31.0 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_4 PF02390.12 KOO24628.1 - 1.2e-07 31.0 0.0 2.8e-05 23.2 0.0 2.3 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.9 KOO24628.1 - 1.1e-06 28.1 0.0 2.6e-06 26.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_PK PF05891.7 KOO24628.1 - 1.2e-05 24.7 0.0 2.1e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase PCMT PF01135.14 KOO24628.1 - 6.6e-05 22.5 0.0 0.0001 21.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) NAS PF03059.11 KOO24628.1 - 6.8e-05 22.1 0.0 9.3e-05 21.7 0.0 1.1 1 0 0 1 1 1 1 Nicotianamine synthase protein Methyltransf_8 PF05148.10 KOO24628.1 - 0.00014 21.5 0.0 0.00038 20.1 0.0 1.7 1 1 0 1 1 1 1 Hypothetical methyltransferase DREV PF05219.7 KOO24628.1 - 0.00033 19.6 0.0 0.00075 18.4 0.0 1.5 2 0 0 2 2 2 1 DREV methyltransferase Methyltransf_32 PF13679.1 KOO24628.1 - 0.0019 17.8 0.0 0.0031 17.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 KOO24628.1 - 0.002 17.5 0.0 0.0031 16.8 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW ADH_zinc_N PF00107.21 KOO24628.1 - 0.0024 17.4 0.0 0.0061 16.1 0.0 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase NodS PF05401.6 KOO24628.1 - 0.0027 17.1 0.0 0.0042 16.4 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_24 PF13578.1 KOO24628.1 - 0.0054 17.5 0.0 0.011 16.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 KOO24628.1 - 0.0071 16.3 0.0 0.021 14.8 0.0 1.7 1 1 0 1 1 1 1 FtsJ-like methyltransferase Shikimate_DH PF01488.15 KOO24628.1 - 0.01 15.9 0.0 0.015 15.3 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TehB PF03848.9 KOO24628.1 - 0.017 14.2 0.0 0.083 12.0 0.0 2.0 3 0 0 3 3 3 0 Tellurite resistance protein TehB Methyltransf_9 PF08003.6 KOO24628.1 - 0.021 13.5 0.0 0.027 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) FmrO PF07091.6 KOO24628.1 - 0.037 13.0 0.0 0.066 12.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) DUF938 PF06080.7 KOO24628.1 - 0.085 12.3 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) TPR_11 PF13414.1 KOO24629.1 - 0.00059 19.4 0.6 0.0031 17.1 0.1 2.1 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.12 KOO24629.1 - 0.0025 17.5 0.5 0.18 11.8 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat PTR PF12789.2 KOO24630.1 - 0.088 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Phage tail repeat like Epimerase PF01370.16 KOO24631.1 - 0.039 13.3 0.0 0.19 11.1 0.0 2.1 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF2849 PF11011.3 KOO24631.1 - 0.9 9.8 3.8 4.9 7.4 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2849) Sugar_tr PF00083.19 KOO24632.1 - 0.0047 15.5 1.4 0.0047 15.5 0.9 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter HEV_ORF1 PF02444.11 KOO24632.1 - 0.16 12.1 0.7 0.41 10.8 0.1 1.8 1 1 1 2 2 2 0 Hepatitis E virus ORF-2 (Putative capsid protein) MFS_1 PF07690.11 KOO24632.1 - 0.18 10.5 14.3 0.053 12.2 6.7 1.9 1 1 1 2 2 2 0 Major Facilitator Superfamily MerC PF03203.9 KOO24632.1 - 0.26 11.6 3.7 0.35 11.2 2.3 1.5 1 1 0 1 1 1 0 MerC mercury resistance protein Mac PF12464.3 KOO24634.1 - 0.0021 18.0 1.6 1.2 9.2 0.3 2.7 3 0 0 3 3 3 2 Maltose acetyltransferase UPF0139 PF03669.8 KOO24634.1 - 0.0048 16.4 2.0 0.0052 16.2 0.0 1.9 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0139) GCIP PF13324.1 KOO24635.1 - 0.00033 19.9 2.2 0.00095 18.4 1.5 1.7 1 1 0 1 1 1 1 Grap2 and cyclin-D-interacting Dynactin_p22 PF07426.6 KOO24635.1 - 0.017 14.4 0.1 0.027 13.7 0.1 1.3 1 0 0 1 1 1 0 Dynactin subunit p22 MbeB_N PF04837.7 KOO24635.1 - 0.053 13.6 0.2 0.17 12.0 0.2 1.9 1 0 0 1 1 1 0 MbeB-like, N-term conserved region Mu-like_Pro PF10123.4 KOO24635.1 - 0.2 11.0 7.1 0.38 10.1 5.0 1.4 1 1 0 1 1 1 0 Mu-like prophage I protein I_LWEQ PF01608.12 KOO24635.1 - 1.4 8.8 6.3 2.5 8.0 0.3 2.9 2 1 1 3 3 3 0 I/LWEQ domain PEP-utilisers_N PF05524.8 KOO24635.1 - 1.6 8.5 7.8 0.78 9.5 3.3 2.0 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal DnaJ PF00226.26 KOO24636.1 - 1.3e-16 60.0 0.1 3.8e-16 58.5 0.1 1.9 1 0 0 1 1 1 1 DnaJ domain ADH_zinc_N PF00107.21 KOO24636.1 - 1.3e-10 40.8 0.0 4.4e-10 39.2 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase SAM_1 PF00536.25 KOO24636.1 - 9.8e-06 25.6 0.1 0.00012 22.2 0.1 2.7 2 1 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 KOO24636.1 - 0.0024 17.6 0.2 0.027 14.2 0.1 2.8 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) ADH_N PF08240.7 KOO24636.1 - 0.11 12.2 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Ribosomal_L15e PF00827.12 KOO24637.1 - 8.6e-87 289.6 11.6 9.7e-87 289.4 8.0 1.0 1 0 0 1 1 1 1 Ribosomal L15 LRR_6 PF13516.1 KOO24638.1 - 1.3e-06 27.8 2.0 0.0032 17.3 0.1 3.4 3 0 0 3 3 3 2 Leucine Rich repeat Metallophos_2 PF12850.2 KOO24640.1 - 9.3e-06 25.5 0.1 1.6e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 KOO24640.1 - 0.0012 18.2 2.8 0.015 14.6 1.9 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Dioxygenase_C PF00775.16 KOO24641.1 - 0.082 12.1 0.1 0.14 11.4 0.1 1.3 1 0 0 1 1 1 0 Dioxygenase PAE PF03283.8 KOO24642.1 - 6.2e-34 117.2 0.1 5.4e-30 104.2 0.0 2.0 1 1 1 2 2 2 2 Pectinacetylesterase Aldo_ket_red PF00248.16 KOO24643.1 - 8.9e-56 188.7 0.0 1e-55 188.5 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Adaptin_N PF01602.15 KOO24645.1 - 9e-95 317.9 8.7 1.3e-94 317.4 6.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.1 KOO24645.1 - 1e-61 206.3 0.1 2.4e-61 205.1 0.0 1.7 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.7 KOO24645.1 - 1.8e-52 176.7 0.7 4.2e-52 175.5 0.1 1.9 2 0 0 2 2 2 1 Coatomer beta C-terminal region HEAT_2 PF13646.1 KOO24645.1 - 3.6e-06 27.1 5.2 1.9 8.8 0.0 4.8 2 1 2 4 4 4 3 HEAT repeats Cnd1 PF12717.2 KOO24645.1 - 0.00033 20.5 1.8 0.34 10.7 0.1 2.8 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 KOO24645.1 - 0.025 14.6 4.0 1 9.6 0.0 3.9 4 0 0 4 4 4 0 HEAT repeat ParcG PF10274.4 KOO24645.1 - 0.75 9.6 5.4 7.2 6.4 0.5 3.6 3 1 1 4 4 4 0 Parkin co-regulated protein Bestrophin PF01062.16 KOO24647.1 - 0.21 10.4 0.4 0.39 9.6 0.3 1.4 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel DUF3366 PF11846.3 KOO24647.1 - 1.4 8.7 5.1 0.21 11.4 0.4 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF3366) Kinesin PF00225.18 KOO24649.1 - 9.4e-86 287.5 0.0 1.2e-85 287.1 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain LRR_4 PF12799.2 KOO24655.1 - 4.5e-21 74.0 56.6 3.7e-06 26.4 2.5 10.7 8 3 3 11 11 11 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO24655.1 - 3.1e-14 52.4 33.6 1.4e-08 34.3 5.3 8.2 6 3 4 10 10 10 6 Leucine rich repeat LRR_1 PF00560.28 KOO24655.1 - 5e-10 37.9 41.3 0.16 12.1 0.3 14.0 16 1 1 17 17 17 3 Leucine Rich Repeat LRR_6 PF13516.1 KOO24655.1 - 5.2e-09 35.2 62.4 0.29 11.3 0.2 16.3 17 1 1 18 18 18 4 Leucine Rich repeat LRR_7 PF13504.1 KOO24655.1 - 4.3e-07 29.0 47.1 0.082 13.1 0.5 14.5 15 1 0 15 15 15 3 Leucine rich repeat Ras PF00071.17 KOO24655.1 - 0.0003 20.2 0.0 0.00061 19.2 0.0 1.5 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO24655.1 - 0.016 15.6 0.0 0.037 14.5 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein DUF1256 PF06866.6 KOO24655.1 - 0.07 12.3 0.1 0.39 9.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1256) Gtr1_RagA PF04670.7 KOO24655.1 - 0.26 10.4 0.0 0.53 9.3 0.0 1.5 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region NACHT PF05729.7 KOO24656.1 - 0.0067 16.0 0.1 0.036 13.7 0.1 2.2 1 1 0 1 1 1 1 NACHT domain AAA_19 PF13245.1 KOO24656.1 - 0.018 14.8 0.2 0.068 12.9 0.1 2.0 1 0 0 1 1 1 0 Part of AAA domain AAA PF00004.24 KOO24656.1 - 0.053 13.7 0.0 0.18 12.0 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 KOO24657.1 - 1.2e-14 54.4 0.1 1.9e-14 53.7 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KOO24657.1 - 0.00034 20.7 0.0 0.00057 20.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOO24657.1 - 0.0012 19.0 0.0 0.0027 18.0 0.0 1.4 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.5 KOO24657.1 - 0.0022 17.2 0.0 1.4 8.0 0.0 2.4 3 0 0 3 3 3 2 Chromatin associated protein KTI12 Zeta_toxin PF06414.7 KOO24657.1 - 0.003 16.6 0.1 0.37 9.8 0.0 2.2 2 0 0 2 2 2 2 Zeta toxin Viral_helicase1 PF01443.13 KOO24657.1 - 0.015 14.8 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.1 KOO24657.1 - 0.074 13.0 0.2 0.13 12.2 0.2 1.5 1 1 0 1 1 1 0 AAA ATPase domain Glyco_hydro_30 PF02055.11 KOO24658.1 - 5.7e-82 275.5 0.5 6.9e-80 268.6 0.0 2.1 2 0 0 2 2 2 2 O-Glycosyl hydrolase family 30 Ricin_B_lectin PF00652.17 KOO24658.1 - 1.9e-05 24.6 0.0 0.011 15.6 0.0 3.0 1 1 2 3 3 3 3 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.1 KOO24658.1 - 0.007 16.7 0.0 0.22 11.8 0.0 2.9 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like Peptidase_M14 PF00246.19 KOO24659.1 - 5.5e-28 98.3 0.0 1e-27 97.4 0.0 1.4 1 0 0 1 1 1 1 Zinc carboxypeptidase Cupin_4 PF08007.7 KOO24664.1 - 1e-07 31.5 0.6 3.3e-07 29.8 0.0 2.0 2 1 0 2 2 2 1 Cupin superfamily protein Cupin_8 PF13621.1 KOO24664.1 - 6.4e-07 29.1 0.0 1.4e-06 28.0 0.0 1.6 1 1 0 1 1 1 1 Cupin-like domain AraC_binding PF02311.14 KOO24664.1 - 0.051 13.2 0.1 0.13 11.8 0.0 1.8 2 0 0 2 2 2 0 AraC-like ligand binding domain 2OG-FeII_Oxy_3 PF13640.1 KOO24664.1 - 0.065 13.7 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily HECT PF00632.20 KOO24665.1 - 1.2e-85 287.4 0.0 1.6e-85 287.1 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) QRPTase_C PF01729.14 KOO24666.1 - 8.4e-52 175.1 0.0 1.2e-51 174.5 0.0 1.2 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.11 KOO24666.1 - 2.8e-19 68.7 0.0 5.9e-19 67.6 0.0 1.6 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain PNPase_C PF12111.3 KOO24667.1 - 6 6.1 6.6 1.2 8.3 1.1 2.2 2 0 0 2 2 2 0 Polyribonucleotide phosphorylase C terminal DUF3110 PF11360.3 KOO24668.1 - 1.8e-14 53.2 0.0 2.6e-10 39.9 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3110) Metallophos PF00149.23 KOO24668.1 - 0.006 15.9 0.9 0.043 13.2 0.0 2.1 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KOO24668.1 - 0.017 14.9 0.0 0.11 12.2 0.0 2.1 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain ParBc PF02195.13 KOO24670.1 - 0.078 13.0 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 ParB-like nuclease domain THF_DHG_CYH PF00763.18 KOO24671.1 - 8.6e-18 64.4 0.0 1.4e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.14 KOO24671.1 - 2e-15 56.2 2.2 1.8e-12 46.6 1.5 3.1 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain EF-hand_6 PF13405.1 KOO24672.1 - 8.2e-15 53.3 0.1 6.9e-07 28.6 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO24672.1 - 4.7e-14 50.9 0.9 1.6e-06 27.1 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.27 KOO24672.1 - 1.2e-13 49.2 0.5 4e-06 25.7 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO24672.1 - 4.5e-10 39.5 3.5 1.6e-07 31.3 0.1 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO24672.1 - 3.8e-08 32.8 0.6 0.001 18.6 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair MCM PF00493.18 KOO24673.1 - 2.6e-103 345.3 0.1 4.1e-103 344.6 0.0 1.2 1 0 0 1 1 1 1 MCM2/3/5 family Mg_chelatase PF01078.16 KOO24673.1 - 3.3e-08 32.9 0.2 2.9e-05 23.3 0.0 2.7 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 KOO24673.1 - 8e-08 32.1 0.0 1.6e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.21 KOO24673.1 - 4.6e-05 22.9 0.1 0.0021 17.5 0.1 2.5 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_22 PF13401.1 KOO24673.1 - 0.00055 20.0 0.6 0.014 15.5 0.1 2.8 2 1 0 2 2 2 1 AAA domain MCM_N PF14551.1 KOO24673.1 - 0.0012 19.3 0.0 0.0022 18.4 0.0 1.4 1 0 0 1 1 1 1 MCM N-terminal domain AAA_3 PF07726.6 KOO24673.1 - 0.0015 18.1 0.0 0.0038 16.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) C1_4 PF07975.7 KOO24673.1 - 0.0038 17.1 0.2 0.0038 17.1 0.2 1.9 2 0 0 2 2 1 1 TFIIH C1-like domain AAA PF00004.24 KOO24673.1 - 0.061 13.5 0.1 0.18 11.9 0.1 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO24673.1 - 0.67 9.9 5.3 0.19 11.6 0.3 2.4 2 1 0 2 2 2 0 AAA ATPase domain Ribosomal_60s PF00428.14 KOO24673.1 - 7.3 7.0 9.0 1.8 9.0 3.4 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein OTU PF02338.14 KOO24674.1 - 2.3e-13 50.8 0.0 3.4e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 KOO24674.1 - 0.0056 16.0 0.0 0.0098 15.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase C65 Otubain VWA_2 PF13519.1 KOO24675.1 - 6.4e-13 49.1 0.1 8e-13 48.8 0.1 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 KOO24675.1 - 8.8e-08 32.0 0.0 1.1e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Med25_VWA PF11265.3 KOO24675.1 - 0.0028 16.7 0.0 0.0089 15.0 0.0 1.8 1 1 0 1 1 1 1 Mediator complex subunit 25 von Willebrand factor type A VWA_3 PF13768.1 KOO24675.1 - 0.029 14.0 0.0 0.048 13.3 0.0 1.3 1 1 0 1 1 1 0 von Willebrand factor type A domain DEAD PF00270.24 KOO24676.1 - 7.4e-29 100.3 0.0 3.2e-27 95.0 0.0 2.6 2 1 1 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO24676.1 - 5e-17 61.5 0.0 1.1e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_IV_N PF12462.3 KOO24676.1 - 0.35 10.5 2.7 0.66 9.6 1.9 1.4 1 0 0 1 1 1 0 DNA helicase IV / RNA helicase N terminal NHR2 PF08788.6 KOO24677.1 - 0.063 12.7 0.1 0.17 11.4 0.1 1.8 1 0 0 1 1 1 0 NHR2 domain like HSP70 PF00012.15 KOO24678.1 - 1.5e-66 224.6 0.1 3.4e-65 220.1 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 KOO24678.1 - 2.2e-14 52.8 0.4 3.4e-12 45.6 0.0 2.5 3 0 0 3 3 3 2 MreB/Mbl protein FtsA PF14450.1 KOO24678.1 - 0.00024 20.9 0.8 3.3 7.5 0.0 3.3 3 0 0 3 3 3 3 Cell division protein FtsA Transket_pyr PF02779.19 KOO24679.1 - 9.3e-66 220.7 0.0 1.9e-65 219.7 0.0 1.6 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 KOO24679.1 - 6.1e-62 209.0 0.0 8.6e-62 208.5 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component WD40 PF00400.27 KOO24680.1 - 4.9e-79 257.6 42.0 1.3e-12 47.0 0.3 9.0 9 0 0 9 9 9 8 WD domain, G-beta repeat PD40 PF07676.7 KOO24680.1 - 2.2e-10 39.9 5.7 6.2 6.6 0.0 6.6 6 0 0 6 6 6 6 WD40-like Beta Propeller Repeat AAA_16 PF13191.1 KOO24680.1 - 5.4e-10 39.5 1.7 2.6e-09 37.3 0.1 2.5 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.7 KOO24680.1 - 3.2e-06 26.9 0.0 6e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 NACHT domain NHL PF01436.16 KOO24681.1 - 7.1e-28 95.1 0.5 1.1e-07 31.4 0.0 5.4 5 0 0 5 5 5 5 NHL repeat SGL PF08450.7 KOO24681.1 - 4.9e-09 35.9 0.3 0.00041 19.7 0.0 4.1 3 2 0 3 3 3 3 SMP-30/Gluconolaconase/LRE-like region Glyco_transf_20 PF00982.16 KOO24682.1 - 1.6e-96 323.6 0.0 9.1e-58 195.8 0.0 3.3 3 0 0 3 3 3 3 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 KOO24682.1 - 1.4e-36 125.5 0.0 2.5e-36 124.7 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase HlyIII PF03006.15 KOO24683.1 - 2.6e-17 63.0 13.5 3.1e-17 62.7 9.3 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF1129 PF06570.6 KOO24683.1 - 0.0089 15.3 0.8 0.014 14.7 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1129) DUF3325 PF11804.3 KOO24683.1 - 8.4 6.3 14.6 0.63 10.0 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3325) Myosin_head PF00063.16 KOO24684.1 - 8.1e-145 483.5 0.0 7e-126 420.9 0.0 2.4 1 1 1 2 2 2 2 Myosin head (motor domain) WW PF00397.21 KOO24684.1 - 6.7e-09 35.4 9.3 2.5e-07 30.4 0.2 2.9 3 0 0 3 3 3 2 WW domain IQ PF00612.22 KOO24684.1 - 9.6e-06 24.8 19.3 0.0038 16.7 1.2 5.1 4 0 0 4 4 4 3 IQ calmodulin-binding motif AAA_22 PF13401.1 KOO24684.1 - 0.0039 17.3 0.1 0.035 14.2 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.1 KOO24684.1 - 0.016 14.9 3.4 0.029 14.1 0.0 2.9 2 0 0 2 2 2 0 Part of AAA domain Tubulin PF00091.20 KOO24685.1 - 1.5e-25 90.2 0.1 7.9e-25 87.9 0.1 2.0 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain FtsZ_C PF12327.3 KOO24685.1 - 0.00012 22.1 3.4 0.00024 21.0 0.0 2.9 3 0 0 3 3 3 1 FtsZ family, C-terminal domain CO_deh_flav_C PF03450.12 KOO24685.1 - 0.0059 16.5 0.1 0.0059 16.5 0.1 3.2 3 0 0 3 3 3 1 CO dehydrogenase flavoprotein C-terminal domain Ank_2 PF12796.2 KOO24686.1 - 8e-15 54.9 2.6 1.3e-07 31.8 0.1 3.0 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO24686.1 - 4.2e-14 51.2 1.3 3.3e-06 26.7 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.25 KOO24686.1 - 5.3e-12 44.9 3.3 5.6e-07 29.0 0.0 3.7 3 1 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOO24686.1 - 1.5e-11 44.4 3.4 8.6e-06 26.1 0.1 3.5 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO24686.1 - 5.3e-08 32.8 4.0 8.8e-06 25.8 0.1 3.5 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Beta_helix PF13229.1 KOO24687.1 - 2.7e-19 69.4 7.8 2.8e-18 66.1 5.1 2.2 1 1 0 1 1 1 1 Right handed beta helix region NosD PF05048.8 KOO24687.1 - 3.1e-14 52.6 0.1 9.7e-08 31.4 0.0 2.1 1 1 1 2 2 2 2 Periplasmic copper-binding protein (NosD) DUF1565 PF07602.6 KOO24687.1 - 3.8e-06 26.2 0.9 0.052 12.6 0.0 2.6 2 1 0 2 2 2 2 Protein of unknown function (DUF1565) NT-C2 PF10358.4 KOO24688.1 - 4.9e-09 35.8 0.1 6.6e-08 32.1 0.0 2.2 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins Orbi_VP5 PF00901.12 KOO24688.1 - 0.017 13.3 3.0 0.021 13.0 2.1 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 Scaffolding_pro PF11418.3 KOO24688.1 - 0.045 14.0 2.7 0.14 12.4 1.6 2.1 1 1 1 2 2 2 0 Phi29 scaffolding protein OEP PF02321.13 KOO24688.1 - 9.3 5.7 15.1 17 4.9 10.5 1.4 1 0 0 1 1 1 0 Outer membrane efflux protein ABC_tran PF00005.22 KOO24689.1 - 7.9e-05 22.9 0.0 0.00021 21.5 0.0 1.7 2 0 0 2 2 2 1 ABC transporter SbcCD_C PF13558.1 KOO24689.1 - 0.058 13.3 0.1 0.98 9.3 0.1 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit SMC_N PF02463.14 KOO24689.1 - 0.098 11.8 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain EamA PF00892.15 KOO24690.1 - 7.2e-05 22.8 28.5 0.00016 21.6 5.2 3.2 3 0 0 3 3 3 2 EamA-like transporter family EmrE PF13536.1 KOO24690.1 - 0.0028 17.8 5.4 0.0028 17.8 3.7 3.8 4 0 0 4 4 4 1 Multidrug resistance efflux transporter Sulfotransfer_1 PF00685.22 KOO24690.1 - 0.15 11.2 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 Sulfotransferase domain Sec20 PF03908.8 KOO24691.1 - 1.4e-19 69.5 0.0 3e-19 68.4 0.0 1.6 1 0 0 1 1 1 1 Sec20 Tmemb_cc2 PF10267.4 KOO24691.1 - 0.061 11.9 2.6 0.12 10.9 1.8 1.4 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Ion_trans PF00520.26 KOO24693.1 - 5.7e-15 55.1 7.0 1.3e-14 53.9 4.8 1.5 1 1 0 1 1 1 1 Ion transport protein Atx10homo_assoc PF09759.4 KOO24694.1 - 6.3e-27 93.3 0.1 1.1e-26 92.5 0.0 1.4 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.8 KOO24694.1 - 0.024 13.7 0.0 0.032 13.3 0.0 1.1 1 0 0 1 1 1 0 Armadillo-like Peptidase_C6 PF00851.13 KOO24695.1 - 0.2 10.2 0.0 0.29 9.7 0.0 1.1 1 0 0 1 1 1 0 Helper component proteinase LRR_6 PF13516.1 KOO24696.1 - 1.9e-11 42.7 4.1 0.12 12.5 0.0 7.5 8 1 0 8 8 7 2 Leucine Rich repeat EF-hand_1 PF00036.27 KOO24696.1 - 5.8e-11 40.8 1.7 1.5e-05 23.9 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO24696.1 - 2.1e-09 37.3 0.3 6e-09 35.9 0.2 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO24696.1 - 4.8e-07 29.1 1.8 0.015 15.1 0.2 2.9 3 0 0 3 3 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO24696.1 - 1.2e-06 27.5 2.2 0.012 14.9 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO24696.1 - 1.4e-05 24.6 3.8 7.4e-05 22.2 0.7 2.9 2 1 1 3 3 3 1 EF-hand domain pair LRR_4 PF12799.2 KOO24696.1 - 8.2e-05 22.1 0.2 2.9 7.5 0.0 5.4 7 1 0 7 7 7 2 Leucine Rich repeats (2 copies) EF-hand_9 PF14658.1 KOO24696.1 - 0.00015 21.6 0.5 0.00031 20.6 0.0 1.8 2 0 0 2 2 1 1 EF-hand domain LRR_7 PF13504.1 KOO24696.1 - 0.00018 21.1 3.3 4.3 7.9 0.0 6.3 7 0 0 7 7 6 1 Leucine rich repeat LRR_1 PF00560.28 KOO24696.1 - 0.002 17.9 6.4 13 6.2 0.0 6.1 7 0 0 7 7 6 0 Leucine Rich Repeat SAM_2 PF07647.12 KOO24696.1 - 0.0037 17.0 0.0 0.021 14.6 0.0 2.4 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) LRR_8 PF13855.1 KOO24696.1 - 0.0049 16.6 0.6 22 4.9 0.0 4.7 4 1 0 5 5 4 0 Leucine rich repeat SAM_1 PF00536.25 KOO24696.1 - 0.013 15.7 0.0 0.23 11.6 0.0 2.7 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) UPF0561 PF10573.4 KOO24696.1 - 0.022 14.5 0.0 0.062 13.1 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 Aa_trans PF01490.13 KOO24697.1 - 1.1e-63 215.1 15.6 1.8e-63 214.4 10.8 1.3 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 KOO24697.1 - 1.1e-07 31.0 6.1 2.7e-07 29.7 4.2 1.6 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Nucleotid_trans PF03407.11 KOO24699.1 - 1.3e-08 34.9 0.0 1.8e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase DUF1012 PF06241.7 KOO24700.1 - 4.1e-07 29.8 0.0 6.8e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1012) TrkA_N PF02254.13 KOO24700.1 - 0.005 16.8 1.6 0.013 15.4 0.1 2.3 2 0 0 2 2 2 1 TrkA-N domain TrkA_C PF02080.16 KOO24700.1 - 0.01 15.4 0.0 0.044 13.3 0.0 2.2 1 0 0 1 1 1 1 TrkA-C domain NHL PF01436.16 KOO24703.1 - 1.9e-10 40.1 8.4 0.00048 19.9 0.0 5.9 6 0 0 6 6 6 3 NHL repeat Lactonase PF10282.4 KOO24703.1 - 0.0021 17.2 0.0 0.0056 15.8 0.0 1.7 2 0 0 2 2 2 1 Lactonase, 7-bladed beta-propeller PQQ_3 PF13570.1 KOO24703.1 - 0.95 9.8 7.1 1.2 9.4 0.0 3.9 5 0 0 5 5 5 0 PQQ-like domain LRR_8 PF13855.1 KOO24704.1 - 3e-07 30.1 0.1 6.7e-07 28.9 0.1 1.6 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.2 KOO24704.1 - 5.4e-07 29.0 4.1 0.00049 19.6 0.4 2.9 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO24704.1 - 0.0001 22.0 0.6 0.068 13.2 0.0 4.3 5 0 0 5 5 5 1 Leucine Rich repeat LRR_1 PF00560.28 KOO24704.1 - 0.0003 20.3 0.4 0.012 15.5 0.0 3.4 3 0 0 3 3 3 1 Leucine Rich Repeat LRR_7 PF13504.1 KOO24704.1 - 0.0028 17.5 1.9 0.3 11.4 0.1 4.3 5 0 0 5 5 5 1 Leucine rich repeat TRP PF06011.7 KOO24704.1 - 0.041 12.4 0.2 0.058 11.9 0.1 1.1 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel DUF2681 PF10883.3 KOO24705.1 - 0.14 12.3 1.1 0.39 10.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DUF4131 PF13567.1 KOO24705.1 - 4.9 6.5 10.1 8.4 5.7 4.6 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) Pkinase PF00069.20 KOO24706.1 - 5.6e-57 192.8 0.0 8.9e-57 192.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO24706.1 - 4.1e-29 101.4 0.0 6.1e-29 100.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Seadorna_VP7 PF07387.6 KOO24706.1 - 5.9e-05 22.0 0.2 0.00023 20.1 0.0 1.8 1 1 1 2 2 2 1 Seadornavirus VP7 RIO1 PF01163.17 KOO24706.1 - 0.00039 19.8 0.0 0.00059 19.2 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.1 KOO24706.1 - 0.00053 19.0 0.1 0.022 13.7 0.1 2.2 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 KOO24706.1 - 0.017 14.9 0.2 0.049 13.3 0.1 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family Herpes_UL51 PF04540.8 KOO24707.1 - 0.0064 16.0 0.3 0.013 15.0 0.2 1.6 1 1 0 1 1 1 1 Herpesvirus UL51 protein Vps26 PF03643.10 KOO24708.1 - 1.1e-113 378.6 2.1 1.2e-113 378.4 1.4 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.24 KOO24708.1 - 4.8e-05 23.2 3.2 0.0015 18.3 0.3 3.2 3 1 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain COX3 PF00510.13 KOO24708.1 - 0.14 11.5 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase subunit III SGS PF05002.10 KOO24709.1 - 1.9e-24 85.2 7.5 3.7e-24 84.2 5.2 1.5 1 0 0 1 1 1 1 SGS domain CS PF04969.11 KOO24709.1 - 7e-18 64.9 1.2 1.1e-17 64.2 0.8 1.3 1 0 0 1 1 1 1 CS domain TPR_11 PF13414.1 KOO24709.1 - 1e-16 60.3 6.4 2.5e-13 49.4 0.4 2.5 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 KOO24709.1 - 4.6e-12 45.0 7.5 0.00015 21.2 0.2 3.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO24709.1 - 1.6e-11 43.2 10.3 4.3e-05 23.1 0.5 3.9 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO24709.1 - 2.5e-09 37.5 14.7 3.3e-08 33.9 1.3 3.0 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO24709.1 - 2.5e-07 30.9 3.4 0.0002 21.6 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO24709.1 - 1.4e-05 24.5 1.8 0.0025 17.4 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO24709.1 - 1.6e-05 24.6 0.7 0.0015 18.5 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 KOO24709.1 - 3.1e-05 24.0 2.8 6.6e-05 22.9 2.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 KOO24709.1 - 3.2e-05 24.1 6.1 0.2 12.3 0.5 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO24709.1 - 0.00021 21.1 6.1 0.00084 19.2 1.8 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO24709.1 - 0.00033 20.4 3.5 0.067 13.0 0.1 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat LELP1 PF15042.1 KOO24709.1 - 0.0019 18.3 5.0 0.0035 17.5 3.5 1.3 1 0 0 1 1 1 1 Late cornified envelope-like proline-rich protein 1 TPR_7 PF13176.1 KOO24709.1 - 0.012 15.3 4.8 1.8 8.5 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.1 KOO24709.1 - 0.048 13.7 6.7 0.19 11.8 2.3 3.2 3 2 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO24709.1 - 1 9.9 6.2 4.6 7.9 0.7 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Kinesin PF00225.18 KOO24710.1 - 2.6e-57 194.0 0.0 3.3e-57 193.6 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain zf-C3HC4_3 PF13920.1 KOO24710.1 - 0.00014 21.4 7.8 0.00029 20.4 5.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO24710.1 - 0.0002 21.2 10.8 0.0005 20.0 7.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO24710.1 - 0.00044 19.9 6.8 0.00096 18.8 4.7 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 KOO24710.1 - 0.00049 19.6 8.0 0.0011 18.5 5.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.1 KOO24710.1 - 0.0022 17.7 6.2 0.0052 16.5 4.3 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_2 PF13639.1 KOO24710.1 - 0.0028 17.4 10.4 0.0096 15.7 7.2 2.0 1 0 0 1 1 1 1 Ring finger domain DZR PF12773.2 KOO24710.1 - 0.18 11.6 2.9 0.49 10.2 2.0 1.8 1 0 0 1 1 1 0 Double zinc ribbon zf-MIZ PF02891.15 KOO24710.1 - 1.3 8.6 10.2 3.1 7.3 7.1 1.7 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger PqiA PF04403.8 KOO24711.1 - 5.2e-12 45.6 22.9 1.7e-09 37.4 5.6 2.5 2 0 0 2 2 2 2 Paraquat-inducible protein A Proteasome PF00227.21 KOO24712.1 - 2.9e-52 176.7 0.1 3.4e-52 176.4 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 KOO24712.1 - 1.5e-11 43.4 0.0 2.5e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Abhydrolase_6 PF12697.2 KOO24713.1 - 0.0019 18.0 0.0 0.0033 17.3 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Kinesin PF00225.18 KOO24716.1 - 1.2e-82 277.3 0.0 4.2e-82 275.5 0.0 2.0 2 0 0 2 2 2 1 Kinesin motor domain AAA_17 PF13207.1 KOO24716.1 - 0.034 14.9 0.2 0.18 12.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain AdoHcyase_NAD PF00670.16 KOO24716.1 - 0.074 12.8 0.1 0.2 11.4 0.0 1.7 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain EF-hand_7 PF13499.1 KOO24717.1 - 2e-08 34.2 0.0 4.7e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO24717.1 - 2.4e-07 30.0 0.9 0.00016 21.2 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO24717.1 - 1.8e-06 26.8 0.0 7.6e-05 21.7 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.1 KOO24717.1 - 5.7e-05 22.2 0.2 0.00014 21.0 0.0 1.8 2 0 0 2 2 2 1 EF hand Methyltransf_21 PF05050.7 KOO24719.1 - 1.5e-05 25.0 0.0 2.3e-05 24.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_22 PF13383.1 KOO24719.1 - 0.00066 19.2 0.0 0.00085 18.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain EF-hand_5 PF13202.1 KOO24720.1 - 0.048 13.0 0.2 0.16 11.4 0.0 1.9 2 0 0 2 2 2 0 EF hand EF-hand_7 PF13499.1 KOO24721.1 - 3.2e-11 43.1 0.1 7.9e-11 41.9 0.2 1.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO24721.1 - 2.3e-10 38.9 0.2 1.7e-05 23.8 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO24721.1 - 2.9e-08 32.6 2.5 0.0055 15.9 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO24721.1 - 1.9e-06 27.2 0.0 0.069 13.0 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO24721.1 - 5.6e-05 22.6 0.7 0.0023 17.5 0.2 2.3 1 1 1 2 2 2 1 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO24721.1 - 0.024 14.6 0.1 0.037 14.0 0.0 1.1 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Pro_isomerase PF00160.16 KOO24722.1 - 3.5e-47 160.4 0.0 6.7e-47 159.5 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.7 KOO24722.1 - 7.2e-06 25.3 0.3 2.3e-05 23.7 0.1 1.9 2 1 0 2 2 2 1 Rtf2 RING-finger Methyltransf_21 PF05050.7 KOO24725.1 - 4.8e-14 52.6 0.0 8.6e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase FkbM domain TATR PF03430.8 KOO24726.1 - 5.1 5.6 15.2 6.6 5.2 10.6 1.1 1 0 0 1 1 1 0 Trans-activating transcriptional regulator Filament PF00038.16 KOO24727.1 - 0.0011 18.4 43.2 0.0059 16.1 14.1 3.7 1 1 3 4 4 4 3 Intermediate filament protein CENP-F_leu_zip PF10473.4 KOO24727.1 - 0.011 15.6 3.8 0.011 15.6 2.6 3.4 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_DNA_bd PF12329.3 KOO24727.1 - 0.27 11.0 45.1 0.37 10.6 2.3 4.0 2 1 2 4 4 4 0 TATA element modulatory factor 1 DNA binding Baculo_PEP_C PF04513.7 KOO24727.1 - 0.36 10.6 24.5 1.3 8.8 4.6 3.9 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus cwf21 PF08312.7 KOO24727.1 - 1.4 8.8 14.6 0.43 10.4 0.2 4.9 2 2 1 3 3 3 0 cwf21 domain Tektin PF03148.9 KOO24727.1 - 3.2 6.2 40.3 0.014 13.9 15.5 2.8 1 1 1 2 2 2 0 Tektin family CVNH PF08881.5 KOO24727.1 - 3.7 7.8 6.4 5.3 7.3 0.8 2.8 2 1 1 3 3 3 0 CVNH domain DUF972 PF06156.8 KOO24727.1 - 4.4 7.6 24.9 5.4 7.4 4.7 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF972) Reo_sigmaC PF04582.7 KOO24727.1 - 4.5 6.3 19.0 3.1 6.8 8.0 2.3 1 1 1 2 2 2 0 Reovirus sigma C capsid protein TMF_TATA_bd PF12325.3 KOO24727.1 - 9.7 5.9 39.0 0.26 11.0 4.7 3.5 1 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding EF-hand_6 PF13405.1 KOO24728.1 - 3.2e-21 73.2 0.1 0.00027 20.5 0.0 4.8 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.27 KOO24728.1 - 2.4e-18 63.9 1.2 0.00044 19.3 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO24728.1 - 5.8e-16 58.3 0.2 2.6e-07 30.6 0.0 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO24728.1 - 8.1e-10 37.5 7.2 0.004 16.4 0.1 4.6 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO24728.1 - 2.1e-09 36.8 1.7 0.00083 18.9 0.0 3.8 2 2 2 4 4 4 4 EF-hand domain pair SNARE_assoc PF09335.6 KOO24728.1 - 0.13 12.4 0.0 0.43 10.8 0.0 1.8 1 0 0 1 1 1 0 SNARE associated Golgi protein TPT PF03151.11 KOO24729.1 - 1.1e-16 60.8 9.2 1.1e-16 60.8 6.4 2.1 1 1 1 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 KOO24729.1 - 0.19 11.7 24.9 0.75 9.8 4.1 2.5 2 0 0 2 2 2 0 EamA-like transporter family WD40 PF00400.27 KOO24730.1 - 3.2e-11 42.6 5.4 0.032 14.1 0.0 6.4 7 0 0 7 7 7 3 WD domain, G-beta repeat PQQ_3 PF13570.1 KOO24730.1 - 0.047 13.9 4.9 28 5.1 0.0 4.9 5 0 0 5 5 5 0 PQQ-like domain Gp_dh_N PF00044.19 KOO24731.1 - 2e-29 102.4 0.0 3.2e-29 101.8 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Gp_dh_C PF02800.15 KOO24731.1 - 5.3e-25 87.6 0.0 7.4e-25 87.2 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Foamy_virus_ENV PF03408.9 KOO24731.1 - 0.12 9.9 0.0 0.16 9.4 0.0 1.1 1 0 0 1 1 1 0 Foamy virus envelope protein HlyC PF02794.11 KOO24731.1 - 0.12 11.9 0.0 0.57 9.7 0.0 1.9 2 0 0 2 2 2 0 RTX toxin acyltransferase family SQS_PSY PF00494.14 KOO24732.1 - 4.5e-30 104.8 0.0 9.3e-30 103.8 0.0 1.5 1 0 0 1 1 1 1 Squalene/phytoene synthase NUDIX PF00293.23 KOO24732.1 - 1.6e-23 82.8 0.0 2.8e-23 82.0 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain tRNA-synt_2 PF00152.15 KOO24733.1 - 3.7e-89 298.8 0.0 4.8e-89 298.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 KOO24733.1 - 5.8e-15 54.9 0.0 4.2e-14 52.1 0.0 2.1 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain WHEP-TRS PF00458.15 KOO24733.1 - 3.5e-09 36.1 2.2 7.7e-09 35.0 1.5 1.6 1 0 0 1 1 1 1 WHEP-TRS domain tRNA-synt_2d PF01409.15 KOO24733.1 - 0.00034 19.9 0.0 0.12 11.5 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 KOO24733.1 - 0.011 15.2 0.0 0.2 11.2 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) RuvC PF02075.12 KOO24733.1 - 0.057 13.2 0.7 0.21 11.4 0.4 1.9 2 0 0 2 2 2 0 Crossover junction endodeoxyribonuclease RuvC ERM PF00769.14 KOO24733.1 - 0.12 11.8 3.6 0.19 11.2 2.5 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family G_glu_transpept PF01019.16 KOO24734.1 - 3.1e-55 187.6 0.0 5.5e-55 186.7 0.0 1.4 1 1 0 1 1 1 1 Gamma-glutamyltranspeptidase LRR_6 PF13516.1 KOO24735.1 - 9.2e-14 49.9 11.8 0.026 14.5 0.1 8.1 9 0 0 9 9 9 4 Leucine Rich repeat DUF4476 PF14771.1 KOO24735.1 - 5.5e-09 35.9 0.6 1.2e-08 34.9 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4476) LRR_4 PF12799.2 KOO24735.1 - 2.2e-06 27.1 2.3 1.1 8.9 0.1 4.6 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO24735.1 - 0.00011 21.7 0.2 31 5.1 0.1 6.1 6 1 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.1 KOO24735.1 - 0.011 15.5 8.3 0.16 11.7 0.3 4.3 1 1 4 5 5 5 0 Leucine rich repeat LRR_7 PF13504.1 KOO24735.1 - 1.2 9.5 7.1 1.7e+02 3.1 0.0 5.4 6 0 0 6 6 6 0 Leucine rich repeat HR1 PF02185.11 KOO24735.1 - 2.6 7.8 9.5 1.4 8.7 0.5 3.8 3 0 0 3 3 3 0 Hr1 repeat Ribosomal_L1 PF00687.16 KOO24737.1 - 5.2e-46 156.7 0.0 8.1e-46 156.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family EF-hand_1 PF00036.27 KOO24738.1 - 9.9e-11 40.1 4.3 2.6e-05 23.2 0.1 4.7 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.1 KOO24738.1 - 1.4e-08 34.7 1.1 7e-07 29.2 0.0 3.6 3 2 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO24738.1 - 5.8e-08 31.7 0.4 0.012 14.9 0.1 3.2 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO24738.1 - 2.6e-07 29.9 1.3 0.039 13.8 0.0 4.7 4 1 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.1 KOO24738.1 - 1.5e-06 27.6 0.4 0.0084 15.7 0.0 3.1 2 1 1 3 3 3 2 EF-hand domain pair TerB PF05099.8 KOO24738.1 - 0.025 14.2 0.0 0.067 12.9 0.0 1.7 1 0 0 1 1 1 0 Tellurite resistance protein TerB EF-hand_4 PF12763.2 KOO24738.1 - 0.3 10.8 3.0 0.8 9.4 0.0 3.0 2 2 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand CIA30 PF08547.7 KOO24739.1 - 1.1e-05 25.4 0.0 0.00016 21.5 0.0 2.1 2 0 0 2 2 2 1 Complex I intermediate-associated protein 30 (CIA30) Frag1 PF10277.4 KOO24739.1 - 0.027 13.9 0.1 0.1 12.0 0.0 2.0 2 0 0 2 2 2 0 Frag1/DRAM/Sfk1 family DUF2955 PF11168.3 KOO24739.1 - 2.1 8.0 5.8 11 5.6 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2955) Zip PF02535.17 KOO24740.1 - 3.2e-07 29.6 0.0 4.7e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter MFS_1 PF07690.11 KOO24740.1 - 0.0013 17.5 0.6 0.0019 17.0 0.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily SelR PF01641.13 KOO24741.1 - 7.8e-34 116.0 0.6 9.4e-34 115.7 0.4 1.0 1 0 0 1 1 1 1 SelR domain DUF2296 PF10058.4 KOO24741.1 - 0.052 13.2 1.0 0.31 10.8 0.1 2.2 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) zf-Mss51 PF13824.1 KOO24741.1 - 0.058 13.2 3.7 0.069 13.0 0.1 2.6 1 1 1 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 Yippee-Mis18 PF03226.9 KOO24741.1 - 0.45 10.5 2.1 1.5 8.9 1.4 1.9 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly FYVE PF01363.16 KOO24741.1 - 0.62 10.0 3.1 1.4 8.8 2.1 1.7 1 1 0 1 1 1 0 FYVE zinc finger DZR PF12773.2 KOO24741.1 - 0.65 9.8 5.7 2 8.2 0.3 2.2 1 1 1 2 2 2 0 Double zinc ribbon zinc_ribbon_2 PF13240.1 KOO24741.1 - 0.85 9.1 4.5 1.7 8.1 1.0 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zf-CHY PF05495.7 KOO24741.1 - 0.99 9.6 6.0 4.9 7.3 4.2 2.0 1 1 0 1 1 1 0 CHY zinc finger Zn_ribbon_recom PF13408.1 KOO24741.1 - 1.8 8.8 4.4 18 5.6 0.3 2.4 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain Ribosomal_L37e PF01907.14 KOO24741.1 - 2 8.2 8.7 0.29 10.9 2.8 2.1 2 1 0 2 2 2 0 Ribosomal protein L37e Nudix_N_2 PF14803.1 KOO24741.1 - 2.5 7.8 6.5 6.7 6.4 0.4 2.7 3 0 0 3 3 3 0 Nudix N-terminal DUF2757 PF10955.3 KOO24741.1 - 4.3 7.6 5.2 44 4.3 2.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2757) SPC25 PF06703.6 KOO24742.1 - 1.2e-21 76.9 0.0 3.6e-21 75.4 0.0 1.7 1 1 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) Methyltransf_11 PF08241.7 KOO24743.1 - 0.0011 19.4 0.0 0.0018 18.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO24743.1 - 0.019 15.5 0.0 0.041 14.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_26 PF13659.1 KOO24743.1 - 0.02 14.9 0.3 0.057 13.4 0.0 1.9 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.1 KOO24743.1 - 0.056 13.0 0.0 0.064 12.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain SpoU_methylase PF00588.14 KOO24744.1 - 1.3e-24 86.7 0.0 9e-24 83.9 0.0 1.9 2 0 0 2 2 2 1 SpoU rRNA Methylase family SelB-wing_1 PF09105.5 KOO24745.1 - 0.0011 18.6 9.8 17 5.1 0.0 6.9 4 2 2 6 6 6 2 Elongation factor SelB, winged helix CortBP2 PF09727.4 KOO24745.1 - 0.89 9.0 51.9 0.54 9.7 5.8 4.8 1 1 4 5 5 5 0 Cortactin-binding protein-2 PACT_coil_coil PF10495.4 KOO24745.1 - 2.2 8.2 22.6 42 4.1 0.3 7.2 1 1 6 7 7 7 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein LssY_C PF14067.1 KOO24745.1 - 8.4 5.3 24.8 22 3.9 0.3 6.9 1 1 9 10 10 10 0 LssY C-terminus Antirestrict PF03230.8 KOO24746.1 - 0.14 12.2 0.8 0.48 10.4 0.6 1.9 1 0 0 1 1 1 0 Antirestriction protein Exonuc_VII_L PF02601.10 KOO24746.1 - 7.8 5.5 21.3 2.5 7.1 12.2 1.8 1 1 1 2 2 2 0 Exonuclease VII, large subunit NYN PF01936.13 KOO24747.1 - 2.8e-11 43.8 0.0 3.6e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 NYN domain FAM117 PF15388.1 KOO24748.1 - 0.12 11.5 0.1 0.13 11.4 0.1 1.1 1 0 0 1 1 1 0 Protein Family FAM117 HlyD PF00529.15 KOO24748.1 - 0.26 10.5 22.6 0.31 10.3 15.6 1.1 1 0 0 1 1 1 0 HlyD family secretion protein PAT1 PF09770.4 KOO24748.1 - 0.39 8.9 5.0 0.44 8.7 3.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Vfa1 PF08432.5 KOO24748.1 - 0.43 10.5 5.4 0.54 10.2 3.8 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF1501 PF07394.7 KOO24748.1 - 0.9 8.3 7.1 1 8.1 4.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) RIB43A PF05914.7 KOO24748.1 - 1.3 7.5 10.6 1.6 7.2 7.4 1.1 1 0 0 1 1 1 0 RIB43A DUF399 PF04187.8 KOO24749.1 - 5.6e-25 88.0 0.0 1.1e-24 87.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF399 Methyltransf_31 PF13847.1 KOO24749.1 - 4.4e-20 71.8 0.0 7e-20 71.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO24749.1 - 2e-19 69.8 0.1 1.7e-18 66.8 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO24749.1 - 1.9e-14 54.1 0.1 5.8e-14 52.6 0.1 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO24749.1 - 3.8e-11 43.0 1.3 3.8e-11 43.0 0.9 2.6 4 0 0 4 4 4 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO24749.1 - 5.1e-11 42.1 0.0 1.2e-10 40.9 0.0 1.5 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 KOO24749.1 - 1e-10 41.8 0.2 3.2e-10 40.2 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO24749.1 - 1.3e-10 41.2 0.0 2.6e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO24749.1 - 5e-09 36.5 0.0 1e-08 35.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 KOO24749.1 - 1.7e-06 27.2 0.0 2.6e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PCMT PF01135.14 KOO24749.1 - 1e-05 25.1 0.1 4.5e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_8 PF05148.10 KOO24749.1 - 0.00013 21.7 0.0 0.00021 21.0 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_32 PF13679.1 KOO24749.1 - 0.0002 21.0 0.0 0.00047 19.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOO24749.1 - 0.002 17.5 0.0 0.0043 16.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 KOO24749.1 - 0.0075 15.4 0.1 0.012 14.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) DOT1 PF08123.8 KOO24749.1 - 0.016 14.4 0.0 0.026 13.8 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 RRM_6 PF14259.1 KOO24750.1 - 0.00024 21.0 0.0 0.00074 19.4 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO24750.1 - 0.00042 20.1 0.0 0.00084 19.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOO24750.1 - 0.0033 17.0 0.3 0.038 13.6 0.0 2.5 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_19 PF13245.1 KOO24751.1 - 3.6e-07 29.8 0.1 1.2e-06 28.1 0.1 1.9 1 0 0 1 1 1 1 Part of AAA domain UvrD-helicase PF00580.16 KOO24751.1 - 0.0022 17.3 0.0 0.0039 16.5 0.0 1.4 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_25 PF13481.1 KOO24751.1 - 0.0065 15.8 0.0 0.016 14.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 KOO24751.1 - 0.062 12.7 0.1 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Tcf25 PF04910.9 KOO24752.1 - 1.9e-44 152.1 0.0 2.3e-44 151.8 0.0 1.1 1 0 0 1 1 1 1 Transcriptional repressor TCF25 Ion_trans PF00520.26 KOO24753.1 - 7.6e-08 31.8 5.6 1.5e-07 30.8 3.9 1.5 1 0 0 1 1 1 1 Ion transport protein DSPc PF00782.15 KOO24753.1 - 1.7e-06 27.6 0.0 5.6e-06 25.9 0.0 1.8 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KOO24753.1 - 4.1e-06 26.3 0.0 6.5e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 KOO24753.1 - 4.8e-05 23.4 0.2 0.00015 21.8 0.0 1.8 2 0 0 2 2 2 1 Inositol hexakisphosphate PTEN_C2 PF10409.4 KOO24753.1 - 9e-05 22.2 0.2 0.0011 18.7 0.0 2.2 2 0 0 2 2 2 1 C2 domain of PTEN tumour-suppressor protein Y_phosphatase3 PF13350.1 KOO24753.1 - 0.0066 16.7 0.1 0.014 15.6 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family PKD_channel PF08016.7 KOO24753.1 - 0.13 10.6 4.2 0.21 9.9 2.9 1.2 1 0 0 1 1 1 0 Polycystin cation channel FBPase PF00316.15 KOO24754.1 - 7.9e-109 363.4 0.0 1.2e-108 362.8 0.0 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase NPL4 PF05021.10 KOO24754.1 - 7.8e-32 110.6 0.0 1.5e-31 109.7 0.0 1.4 1 0 0 1 1 1 1 NPL4 family UN_NPL4 PF11543.3 KOO24754.1 - 1.6e-05 25.0 0.0 0.00015 21.9 0.0 2.4 1 1 0 1 1 1 1 Nuclear pore localisation protein NPL4 Aminotran_1_2 PF00155.16 KOO24755.1 - 1.1e-33 116.6 0.0 2.4e-33 115.5 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.8 KOO24755.1 - 0.0012 17.6 0.0 0.0035 16.0 0.0 1.7 1 1 0 1 1 1 1 Allinase SLS PF14611.1 KOO24757.1 - 0.063 12.6 1.1 6.3 6.1 0.1 2.5 1 1 2 3 3 3 0 Mitochondrial inner-membrane-bound regulator Glyco_transf_54 PF04666.8 KOO24757.1 - 0.14 10.8 0.0 0.79 8.3 0.0 2.0 1 1 0 1 1 1 0 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region MAGE_N PF12440.3 KOO24757.1 - 7 7.0 10.1 0.26 11.6 1.5 2.5 3 0 0 3 3 3 0 Melanoma associated antigen family N terminal LIX1 PF14954.1 KOO24758.1 - 0.034 13.1 0.1 0.047 12.6 0.1 1.2 1 0 0 1 1 1 0 Limb expression 1 Glyco_transf_18 PF15024.1 KOO24758.1 - 0.081 11.2 5.4 0.1 10.9 3.8 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 18 DUF3119 PF11317.3 KOO24759.1 - 1.1e-16 60.9 0.0 5.3e-16 58.6 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3119) Dynein_IC2 PF11540.3 KOO24759.1 - 0.032 13.6 0.0 0.055 12.8 0.0 1.4 1 0 0 1 1 1 0 Cytoplasmic dynein 1 intermediate chain 2 RNA_pol_Rpb1_1 PF04997.7 KOO24760.1 - 0.019 14.2 0.2 0.019 14.2 0.1 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 1 A_deaminase PF00962.17 KOO24761.1 - 2.3e-06 26.7 0.0 3e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase Filamin PF00630.14 KOO24762.1 - 7.3e-64 212.6 0.0 1.4e-20 73.6 0.0 7.3 7 0 0 7 7 7 7 Filamin/ABP280 repeat Big_1 PF02369.11 KOO24762.1 - 1.2e-08 34.7 2.0 2.8e-05 23.9 0.0 4.5 6 0 0 6 6 6 2 Bacterial Ig-like domain (group 1) YtkA PF13115.1 KOO24762.1 - 1.3e-05 25.4 0.1 0.35 11.2 0.0 3.2 2 0 0 2 2 2 2 YtkA-like Big_3_4 PF13754.1 KOO24762.1 - 0.00013 22.1 2.9 1.6 9.1 0.1 5.4 5 0 0 5 5 5 1 Bacterial Ig-like domain (group 3) SH3_3 PF08239.6 KOO24762.1 - 0.00035 20.6 0.0 0.0013 18.9 0.0 2.0 1 0 0 1 1 1 1 Bacterial SH3 domain Y_Y_Y PF07495.8 KOO24762.1 - 0.002 17.8 0.2 1.2 8.9 0.0 3.9 4 0 0 4 4 4 1 Y_Y_Y domain Neurexophilin PF06312.7 KOO24762.1 - 0.049 12.8 0.1 1 8.5 0.0 2.2 2 0 0 2 2 2 0 Neurexophilin DUF1933 PF09147.5 KOO24762.1 - 0.058 12.8 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1933) Lectin_leg-like PF03388.8 KOO24764.1 - 0.019 14.1 0.0 0.031 13.3 0.0 1.3 1 0 0 1 1 1 0 Legume-like lectin family Amidohydro_1 PF01979.15 KOO24765.1 - 2.4e-59 201.6 1.8 4.7e-59 200.7 1.3 1.5 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.15 KOO24765.1 - 2.6e-49 166.3 2.4 4.7e-49 165.5 1.7 1.4 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_gamma PF00547.13 KOO24765.1 - 2.8e-40 136.3 0.7 6.7e-40 135.1 0.1 2.0 2 0 0 2 2 2 1 Urease, gamma subunit Urease_beta PF00699.15 KOO24765.1 - 3.3e-39 132.7 0.1 7.7e-39 131.5 0.1 1.7 1 0 0 1 1 1 1 Urease beta subunit Amidohydro_3 PF07969.6 KOO24765.1 - 0.00039 19.7 0.5 0.0014 17.9 0.0 2.1 2 0 0 2 2 2 1 Amidohydrolase family Amidohydro_5 PF13594.1 KOO24765.1 - 0.00044 19.9 1.8 0.0013 18.4 1.2 1.8 1 0 0 1 1 1 1 Amidohydrolase LamB_YcsF PF03746.11 KOO24765.1 - 0.092 11.8 0.2 0.34 9.9 0.1 1.9 2 0 0 2 2 2 0 LamB/YcsF family WD40 PF00400.27 KOO24767.1 - 7.6e-14 50.9 8.0 0.035 14.0 0.0 7.6 8 2 1 9 9 9 5 WD domain, G-beta repeat Sm_multidrug_ex PF06695.6 KOO24768.1 - 4.7e-19 68.7 0.9 7.9e-19 68.0 0.6 1.4 1 0 0 1 1 1 1 Putative small multi-drug export protein HCV_NS4a PF01006.15 KOO24768.1 - 0.17 11.4 2.2 0.11 12.0 0.3 1.6 2 0 0 2 2 2 0 Hepatitis C virus non-structural protein NS4a Rab5ip PF07019.7 KOO24768.1 - 0.21 11.7 2.2 0.25 11.5 0.8 1.7 1 1 0 1 1 1 0 Rab5-interacting protein (Rab5ip) CN_hydrolase PF00795.17 KOO24769.1 - 1.1e-16 60.7 0.0 1.8e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_binding_8 PF13450.1 KOO24769.1 - 7.5e-11 41.8 0.2 2.1e-10 40.4 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 KOO24769.1 - 2e-08 33.7 0.0 2e-06 27.1 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.1 KOO24769.1 - 0.0089 15.8 0.0 0.024 14.4 0.0 1.7 1 0 0 1 1 1 1 FAD-NAD(P)-binding DUF4388 PF14332.1 KOO24769.1 - 0.081 12.7 0.0 0.19 11.5 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4388) Pyr_redox_3 PF13738.1 KOO24769.1 - 0.14 12.1 0.1 0.27 11.2 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pkinase PF00069.20 KOO24770.1 - 1.7e-41 142.0 0.0 2.8e-41 141.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO24770.1 - 9.3e-38 129.7 0.0 3.8e-37 127.7 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Adeno_E3_CR2 PF02439.10 KOO24770.1 - 0.014 14.9 0.4 0.025 14.1 0.2 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 SKG6 PF08693.5 KOO24770.1 - 0.024 13.9 4.5 0.058 12.7 3.1 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain RIO1 PF01163.17 KOO24770.1 - 0.03 13.6 0.0 0.055 12.8 0.0 1.3 1 0 0 1 1 1 0 RIO1 family DUF2217 PF10265.4 KOO24770.1 - 0.046 12.4 0.2 0.075 11.7 0.2 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) EphA2_TM PF14575.1 KOO24770.1 - 0.051 13.9 0.1 0.093 13.1 0.1 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain MtrF PF09472.5 KOO24770.1 - 0.056 12.6 6.3 0.12 11.5 4.3 1.6 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Gram_pos_anchor PF00746.16 KOO24770.1 - 0.079 12.7 1.2 0.23 11.3 0.8 1.8 1 0 0 1 1 1 0 Gram positive anchor Syndecan PF01034.15 KOO24770.1 - 0.16 11.6 0.8 0.33 10.6 0.5 1.5 1 0 0 1 1 1 0 Syndecan domain Glycophorin_A PF01102.13 KOO24770.1 - 0.98 9.2 8.2 0.12 12.0 2.2 2.1 2 1 1 3 3 3 0 Glycophorin A Rifin_STEVOR PF02009.11 KOO24770.1 - 3.7 7.1 5.7 0.46 10.0 0.5 1.9 2 0 0 2 2 2 0 Rifin/stevor family CRC_subunit PF08624.5 KOO24771.1 - 0.0083 16.0 0.0 0.061 13.2 0.0 2.0 2 0 0 2 2 2 1 Chromatin remodelling complex Rsc7/Swp82 subunit Peptidase_S9_N PF02897.10 KOO24772.1 - 0.0063 15.1 0.1 0.0074 14.9 0.1 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Formyl_trans_N PF00551.14 KOO24772.1 - 0.044 13.3 1.1 0.053 13.0 0.7 1.2 1 0 0 1 1 1 0 Formyl transferase BTV_NS2 PF04514.7 KOO24772.1 - 0.37 9.6 4.1 0.4 9.5 2.8 1.0 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 DREPP PF05558.7 KOO24772.1 - 1.7 8.4 6.4 2.3 8.0 4.4 1.2 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide Glyco_tranf_2_4 PF13704.1 KOO24773.1 - 9.8e-13 48.2 0.1 1.1e-11 44.8 0.0 2.7 2 0 0 2 2 2 1 Glycosyl transferase family 2 Dynein_heavy PF03028.10 KOO24774.1 - 1.3e-228 760.5 0.0 2.5e-228 759.6 0.0 1.5 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DHC_N1 PF08385.7 KOO24774.1 - 4.9e-130 434.6 0.0 1.1e-129 433.4 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.2 KOO24774.1 - 3.9e-105 350.4 0.0 1.6e-104 348.4 0.0 2.0 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 DHC_N2 PF08393.8 KOO24774.1 - 3e-103 345.4 1.4 3e-103 345.4 1.0 2.8 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.2 KOO24774.1 - 9.4e-96 319.8 0.0 1.8e-95 318.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 MT PF12777.2 KOO24774.1 - 2.7e-80 269.7 5.2 5.1e-80 268.8 3.6 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 KOO24774.1 - 1.5e-73 247.2 0.1 3.8e-73 245.9 0.0 1.7 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_9 PF12781.2 KOO24774.1 - 2.8e-58 196.4 0.1 9.2e-58 194.7 0.0 2.0 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_5 PF07728.9 KOO24774.1 - 5.1e-17 61.9 0.0 5.1e-06 26.2 0.0 5.4 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA PF00004.24 KOO24774.1 - 0.007 16.5 0.0 6.6 6.9 0.0 3.7 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) PPR_1 PF12854.2 KOO24774.1 - 0.38 10.2 3.1 10 5.6 0.6 3.2 3 0 0 3 3 3 0 PPR repeat PAN_1 PF00024.21 KOO24775.1 - 0.00065 19.4 1.3 0.0014 18.3 0.9 1.5 1 0 0 1 1 1 1 PAN domain DUF4203 PF13886.1 KOO24776.1 - 1.5e-05 24.6 24.1 1.9e-05 24.2 16.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) DUF1049 PF06305.6 KOO24776.1 - 8.5 5.9 0.0 8.5 5.9 0.0 3.9 3 2 1 4 4 4 0 Protein of unknown function (DUF1049) OmpA PF00691.15 KOO24777.1 - 0.039 14.3 0.2 0.11 12.9 0.0 1.8 2 0 0 2 2 2 0 OmpA family PfkB PF00294.19 KOO24778.1 - 8.3e-55 186.0 2.0 1.5e-54 185.2 1.4 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Rib_5-P_isom_A PF06026.9 KOO24778.1 - 7.1e-42 142.6 0.0 1.1e-41 142.0 0.0 1.3 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Phos_pyr_kin PF08543.7 KOO24778.1 - 3.5e-07 29.6 0.0 6.9e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase DeoRC PF00455.17 KOO24778.1 - 0.021 14.5 0.1 5.5 6.6 0.0 2.7 2 0 0 2 2 2 0 DeoR C terminal sensor domain CopD PF05425.8 KOO24779.1 - 0.013 15.6 2.2 0.014 15.5 1.1 1.4 1 1 0 1 1 1 0 Copper resistance protein D DUF4203 PF13886.1 KOO24779.1 - 0.017 14.5 7.0 0.029 13.8 4.9 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4203) PTPLA PF04387.9 KOO24779.1 - 0.1 12.0 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase-like protein, PTPLA NfeD PF01957.13 KOO24779.1 - 0.12 12.5 1.0 0.18 11.9 0.4 1.4 1 1 0 1 1 1 0 NfeD-like C-terminal, partner-binding PepSY_TM_2 PF13703.1 KOO24779.1 - 0.14 12.3 0.1 0.14 12.3 0.1 2.1 2 1 1 3 3 3 0 PepSY-associated TM helix Glyco_hydro_20 PF00728.17 KOO24780.1 - 2.6e-59 201.1 0.0 3.5e-59 200.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.1 KOO24780.1 - 2.6e-06 28.0 0.0 6.1e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like GspL_C PF12693.2 KOO24780.1 - 0.99 9.1 8.2 2.1 8.0 2.2 2.9 3 0 0 3 3 3 0 GspL periplasmic domain DUF3417 PF11897.3 KOO24781.1 - 0.036 14.0 0.3 0.036 14.0 0.2 3.2 3 2 1 5 5 5 0 Protein of unknown function (DUF3417) Hemagglutinin PF00509.13 KOO24781.1 - 0.24 9.5 3.9 1 7.3 1.5 2.1 2 0 0 2 2 2 0 Haemagglutinin DUF1664 PF07889.7 KOO24781.1 - 3.3 7.5 20.9 6.3 6.6 0.0 5.3 2 2 4 6 6 6 0 Protein of unknown function (DUF1664) Pro-kuma_activ PF09286.6 KOO24782.1 - 4.9e-21 75.2 0.0 7.8e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.17 KOO24782.1 - 1.6e-07 30.7 0.2 2.8e-07 29.9 0.1 1.3 1 0 0 1 1 1 1 Subtilase family KIAA1430 PF13879.1 KOO24783.1 - 1.2e-05 25.6 9.2 0.011 16.1 0.9 3.1 1 1 1 2 2 2 2 KIAA1430 homologue RcbX PF02341.10 KOO24783.1 - 0.0068 16.5 3.4 0.059 13.5 0.7 2.4 2 0 0 2 2 2 1 RbcX protein NYD-SP28_assoc PF14775.1 KOO24783.1 - 0.019 14.6 5.4 5.6 6.7 0.2 3.4 3 0 0 3 3 3 0 Sperm tail C-terminal domain SlyX PF04102.7 KOO24783.1 - 0.73 10.2 2.8 21 5.5 0.2 2.8 2 0 0 2 2 2 0 SlyX XhlA PF10779.4 KOO24783.1 - 6.5 6.7 8.6 2.7 7.9 1.7 2.9 1 1 1 2 2 2 0 Haemolysin XhlA FAP PF07174.6 KOO24784.1 - 0.55 9.4 6.4 0.69 9.1 4.4 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Ribosomal_L17 PF01196.14 KOO24785.1 - 1e-31 109.3 0.0 1.4e-31 108.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L17 PIN_3 PF13470.1 KOO24786.1 - 5.5 7.6 12.1 0.097 13.3 1.2 3.0 3 0 0 3 3 3 0 PIN domain DnaJ PF00226.26 KOO24787.1 - 1.8e-06 27.5 0.0 2.8e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain GAS PF13851.1 KOO24788.1 - 0.015 14.4 1.8 0.02 14.0 1.2 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.4 KOO24788.1 - 0.24 11.2 3.6 0.33 10.8 2.5 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fez1 PF06818.10 KOO24788.1 - 0.68 9.9 9.4 0.88 9.5 6.5 1.2 1 0 0 1 1 1 0 Fez1 HAUS6_N PF14661.1 KOO24788.1 - 0.84 8.9 12.3 0.91 8.8 8.5 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Atg14 PF10186.4 KOO24788.1 - 1.2 8.0 5.9 1.3 7.8 4.1 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF3166 PF11365.3 KOO24788.1 - 2 8.9 6.4 1.8 9.0 0.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3166) APG6 PF04111.7 KOO24788.1 - 2.7 6.9 4.5 3.3 6.6 3.1 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Mu-like_Pro PF10123.4 KOO24788.1 - 5.6 6.3 18.7 6.3 6.1 12.9 1.1 1 0 0 1 1 1 0 Mu-like prophage I protein HAUS-augmin3 PF14932.1 KOO24788.1 - 6.4 5.8 6.9 7.7 5.6 4.8 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Aldo_ket_red PF00248.16 KOO24790.1 - 9.8e-47 159.1 0.0 1.6e-46 158.4 0.0 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family Val_tRNA-synt_C PF10458.4 KOO24790.1 - 0.052 13.6 2.3 0.12 12.4 1.6 1.7 1 0 0 1 1 1 0 Valyl tRNA synthetase tRNA binding arm DUF1737 PF08410.5 KOO24790.1 - 0.073 12.8 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1737) TPT PF03151.11 KOO24791.1 - 9.1e-22 77.3 5.6 1e-21 77.1 3.9 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.15 KOO24791.1 - 0.0029 17.6 6.8 0.004 17.2 4.7 1.1 1 0 0 1 1 1 1 EamA-like transporter family Hydrolase_3 PF08282.7 KOO24793.1 - 1.5e-19 70.5 0.1 2e-19 70.1 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Tic22 PF04278.7 KOO24793.1 - 1.6e-16 60.4 0.0 2.7e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 Tic22-like family Hydrolase PF00702.21 KOO24793.1 - 0.0084 16.5 0.2 0.028 14.8 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO24793.1 - 0.11 12.6 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase S6PP PF05116.8 KOO24793.1 - 0.15 11.3 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase SAP PF02037.22 KOO24794.1 - 7.4e-10 38.0 0.8 1.3e-09 37.3 0.6 1.4 1 0 0 1 1 1 1 SAP domain SURF2 PF05477.6 KOO24794.1 - 2.2e-06 26.9 0.0 3.7e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Surfeit locus protein 2 (SURF2) RHH_1 PF01402.16 KOO24794.1 - 0.15 11.9 0.1 0.44 10.5 0.1 1.8 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family Sigma70_r3 PF04539.11 KOO24795.1 - 0.027 14.3 1.0 0.11 12.3 0.1 2.3 2 0 0 2 2 2 0 Sigma-70 region 3 ArsD PF06953.6 KOO24795.1 - 0.11 12.6 0.2 1.8 8.7 0.1 2.2 1 1 1 2 2 2 0 Arsenical resistance operon trans-acting repressor ArsD HCV_NS4a PF01006.15 KOO24795.1 - 1.6 8.3 4.6 3.6 7.2 3.2 1.6 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS4a CorA PF01544.13 KOO24796.1 - 1.2e-06 27.7 3.8 1.5e-06 27.4 2.6 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein AA_permease_2 PF13520.1 KOO24797.1 - 2.8e-34 118.4 27.0 3.4e-34 118.1 18.7 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KOO24797.1 - 1.7e-14 53.0 24.6 1.2e-13 50.2 17.0 2.3 1 1 0 1 1 1 1 Amino acid permease EF-hand_5 PF13202.1 KOO24798.1 - 2.6e-14 51.8 6.0 5.4e-07 28.6 0.3 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO24798.1 - 1.3e-12 47.6 4.8 3.2e-12 46.3 3.3 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO24798.1 - 3.9e-12 44.5 9.5 3.7e-06 25.8 0.8 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO24798.1 - 1.5e-10 40.0 6.1 1.9e-05 24.1 0.4 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO24798.1 - 4.4e-07 29.4 7.3 0.00057 19.4 0.5 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.2 KOO24798.1 - 0.006 16.2 3.8 1.6 8.5 0.5 2.7 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand KIAA1430 PF13879.1 KOO24798.1 - 0.011 16.1 7.6 0.011 16.1 5.3 4.2 1 1 1 2 2 2 0 KIAA1430 homologue EF-hand_10 PF14788.1 KOO24798.1 - 0.04 13.5 0.4 0.12 12.0 0.1 1.9 2 0 0 2 2 2 0 EF hand CorA PF01544.13 KOO24798.1 - 0.14 11.1 6.4 0.26 10.2 4.5 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein SPARC_Ca_bdg PF10591.4 KOO24798.1 - 8.1 6.5 7.6 2.5 8.1 0.1 3.4 2 2 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region RseA_N PF03872.8 KOO24800.1 - 0.083 13.2 0.3 1.1 9.6 0.0 2.3 2 0 0 2 2 2 0 Anti sigma-E protein RseA, N-terminal domain DUF328 PF03883.9 KOO24801.1 - 4.7e-48 163.5 0.0 5.8e-48 163.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF328) DUF4413 PF14372.1 KOO24801.1 - 0.044 13.7 0.0 0.071 13.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) PGI PF00342.14 KOO24802.1 - 2e-215 715.8 0.0 2.5e-215 715.4 0.0 1.1 1 0 0 1 1 1 1 Phosphoglucose isomerase EF-hand_7 PF13499.1 KOO24802.1 - 4.9e-23 81.0 2.5 9.7e-11 41.6 0.5 3.2 2 2 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO24802.1 - 1.6e-21 73.8 6.2 1.9e-05 23.6 0.2 4.7 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO24802.1 - 4.9e-18 63.3 7.8 6.6e-05 22.4 0.1 4.8 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 KOO24802.1 - 7.5e-15 54.2 7.8 4.1e-06 26.3 0.5 4.8 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO24802.1 - 1.1e-11 43.4 9.2 0.0017 17.5 0.0 4.5 4 0 0 4 4 4 3 EF hand Ras PF00071.17 KOO24802.1 - 2.5e-11 43.2 0.0 5.5e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 Ras family EF-hand_10 PF14788.1 KOO24802.1 - 4.3e-06 26.3 0.2 2.8 7.6 0.0 4.4 4 0 0 4 4 4 1 EF hand EF-hand_4 PF12763.2 KOO24802.1 - 0.0028 17.3 1.9 0.78 9.5 0.1 4.1 2 2 2 4 4 4 1 Cytoskeletal-regulatory complex EF hand Miro PF08477.8 KOO24802.1 - 0.0067 16.9 0.0 0.015 15.7 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO24802.1 - 0.0072 15.5 0.0 0.016 14.4 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 KOO24802.1 - 0.013 14.6 0.0 0.024 13.8 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit FtsK_SpoIIIE PF01580.13 KOO24802.1 - 0.017 14.5 0.0 0.033 13.6 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family SPARC_Ca_bdg PF10591.4 KOO24802.1 - 0.2 11.6 0.0 16 5.5 0.0 2.4 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region G-alpha PF00503.15 KOO24802.1 - 0.33 9.5 0.1 0.62 8.6 0.1 1.3 1 0 0 1 1 1 0 G-protein alpha subunit RRM_1 PF00076.17 KOO24803.1 - 4e-56 186.5 0.0 1.5e-21 75.7 0.0 5.3 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO24803.1 - 4.1e-49 164.4 0.0 1.7e-14 53.5 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO24803.1 - 1.2e-24 85.8 0.0 5.4e-08 32.5 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 KOO24803.1 - 0.0047 16.6 0.3 0.11 12.2 0.0 3.1 3 1 0 3 3 3 1 Limkain b1 DUF3456 PF11938.3 KOO24804.1 - 0.00018 21.4 3.0 0.0003 20.8 2.1 1.3 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP PP2C PF00481.16 KOO24804.1 - 0.0047 16.3 0.4 0.0072 15.7 0.3 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C DUF2492 PF10678.4 KOO24804.1 - 0.011 15.8 0.6 0.023 14.7 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2492) Mito_carr PF00153.22 KOO24805.1 - 9.8e-39 130.9 0.1 1.6e-26 91.8 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein MFS_1 PF07690.11 KOO24806.1 - 2.6e-32 111.9 46.4 1.7e-25 89.4 17.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3431 PF11913.3 KOO24810.1 - 6.6e-22 78.0 0.4 1.8e-18 66.8 0.0 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF3431) zf-DHHC PF01529.15 KOO24812.1 - 1.9e-29 102.2 0.5 4.5e-29 101.0 0.3 1.7 1 1 0 1 1 1 1 DHHC palmitoyltransferase HMG_box PF00505.14 KOO24813.1 - 8.1e-22 77.2 3.3 8.1e-22 77.2 2.3 3.3 3 1 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO24813.1 - 5.1e-15 55.5 3.0 5.1e-15 55.5 2.1 3.7 3 1 0 3 3 3 1 HMG-box domain PWWP PF00855.12 KOO24813.1 - 4.5e-09 36.3 0.3 4.5e-09 36.3 0.2 3.3 2 1 0 2 2 2 1 PWWP domain Med26 PF08711.6 KOO24813.1 - 6.8e-08 31.8 0.0 1.4e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain DEK_C PF08766.6 KOO24813.1 - 8.8e-05 22.2 0.0 0.0002 21.0 0.0 1.6 1 0 0 1 1 1 1 DEK C terminal domain DUF4554 PF15091.1 KOO24813.1 - 2.2 6.9 6.7 9.1 4.8 4.7 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Tub_2 PF04525.7 KOO24814.1 - 0.0064 15.9 0.0 0.0098 15.2 0.0 1.2 1 0 0 1 1 1 1 Tubby C 2 Glutaredoxin PF00462.19 KOO24815.1 - 1.2e-21 76.3 0.1 1.8e-21 75.8 0.1 1.2 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_9 PF14595.1 KOO24815.1 - 9.5e-05 21.9 0.0 0.00012 21.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin GST_N_3 PF13417.1 KOO24815.1 - 0.0025 17.9 0.0 0.0042 17.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Thioredoxin_2 PF13098.1 KOO24815.1 - 0.014 15.5 0.0 0.019 15.1 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain GST_N_2 PF13409.1 KOO24815.1 - 0.019 14.9 0.0 0.26 11.3 0.0 2.1 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain Thioredoxin_3 PF13192.1 KOO24815.1 - 0.043 13.6 0.1 0.1 12.4 0.1 1.6 1 1 0 1 1 1 0 Thioredoxin domain Zn_ribbon_2 PF12674.2 KOO24815.1 - 0.066 13.5 0.0 0.097 13.0 0.0 1.3 1 0 0 1 1 1 0 Putative zinc ribbon domain DSBA PF01323.15 KOO24815.1 - 0.073 12.6 2.5 0.79 9.2 0.1 2.2 1 1 0 2 2 2 0 DSBA-like thioredoxin domain DUF836 PF05768.9 KOO24815.1 - 0.12 12.7 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Thioredoxin_4 PF13462.1 KOO24815.1 - 0.34 10.8 2.1 1.3 9.0 0.4 2.3 1 1 1 2 2 2 0 Thioredoxin Radical_SAM PF04055.16 KOO24816.1 - 6.7e-10 39.3 0.0 1.2e-09 38.5 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Filamin PF00630.14 KOO24817.1 - 2.3e-45 153.2 0.0 1.4e-12 48.0 0.0 7.1 6 1 0 6 6 6 6 Filamin/ABP280 repeat LRR_6 PF13516.1 KOO24817.1 - 3.4e-21 72.8 39.4 0.019 14.9 0.4 13.3 13 0 0 13 13 12 5 Leucine Rich repeat LRR_4 PF12799.2 KOO24817.1 - 6.3e-12 44.8 15.6 0.21 11.2 0.0 8.0 7 1 3 10 10 10 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO24817.1 - 2.1e-08 33.8 20.1 0.039 13.7 0.0 7.6 5 3 4 9 9 9 2 Leucine rich repeat LRR_1 PF00560.28 KOO24817.1 - 1.2e-07 30.8 1.6 4.5 7.6 0.0 10.3 15 0 0 15 15 13 1 Leucine Rich Repeat C2 PF00168.25 KOO24817.1 - 8.9e-06 25.4 0.0 1.9e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 C2 domain NACHT PF05729.7 KOO24817.1 - 0.0003 20.4 0.0 0.00094 18.8 0.0 1.8 2 0 0 2 2 2 1 NACHT domain NDK PF00334.14 KOO24817.1 - 0.0019 18.0 0.0 0.074 12.8 0.0 2.5 2 0 0 2 2 2 1 Nucleoside diphosphate kinase EF-hand_7 PF13499.1 KOO24817.1 - 0.0027 17.8 0.0 0.024 14.7 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO24817.1 - 0.033 14.0 0.4 1.3 9.1 0.0 3.6 3 1 0 3 3 2 0 EF-hand domain KOW PF00467.24 KOO24817.1 - 0.057 13.1 0.6 0.17 11.6 0.4 1.9 1 0 0 1 1 1 0 KOW motif TFIIIC_delta PF12657.2 KOO24817.1 - 0.069 12.8 0.3 0.41 10.3 0.0 2.4 2 1 0 2 2 2 0 Transcription factor IIIC subunit delta N-term DUF4030 PF13222.1 KOO24817.1 - 0.078 12.6 0.1 87 2.8 0.0 4.3 5 0 0 5 5 5 0 Protein of unknown function (DUF4030) LRR_7 PF13504.1 KOO24817.1 - 0.43 10.9 23.5 2.5e+02 2.6 0.0 11.3 12 0 0 12 12 12 0 Leucine rich repeat MSC PF09402.5 KOO24817.1 - 9.4 4.8 0.3 21 3.7 0.1 1.6 2 0 0 2 2 2 0 Man1-Src1p-C-terminal domain adh_short PF00106.20 KOO24818.1 - 1e-08 35.2 2.0 3.6e-06 26.9 0.0 3.0 3 0 0 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.1 KOO24818.1 - 0.0015 18.3 0.0 0.56 9.9 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 KOO24818.1 - 0.011 15.7 0.1 0.04 13.9 0.0 2.0 2 0 0 2 2 2 0 NADH(P)-binding PARP PF00644.15 KOO24819.1 - 7.8e-63 211.6 0.0 1.2e-62 211.0 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.9 KOO24819.1 - 3.7e-34 117.2 0.0 9.5e-34 115.9 0.0 1.7 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.10 KOO24819.1 - 3.5e-19 68.5 0.4 8.9e-19 67.2 0.3 1.7 1 0 0 1 1 1 1 WGR domain SAP PF02037.22 KOO24819.1 - 1e-09 37.6 0.1 2.8e-09 36.2 0.0 1.8 1 0 0 1 1 1 1 SAP domain WWE PF02825.15 KOO24819.1 - 0.0039 16.5 0.0 0.011 15.1 0.0 1.8 1 1 0 1 1 1 1 WWE domain GHMP_kinases_C PF08544.8 KOO24819.1 - 0.072 13.3 0.0 3 8.1 0.0 2.7 2 0 0 2 2 2 0 GHMP kinases C terminal DUF1992 PF09350.5 KOO24820.1 - 3.1e-20 71.7 1.7 9.9e-20 70.1 0.4 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF1992) Cep57_CLD_2 PF14197.1 KOO24820.1 - 7.4 6.6 11.2 0.35 10.8 1.1 2.8 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 Thioredoxin PF00085.15 KOO24822.1 - 0.00059 19.4 0.1 0.0022 17.6 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin zf-C3HC4_3 PF13920.1 KOO24825.1 - 1.6e-09 37.2 11.0 2.6e-09 36.5 7.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO24825.1 - 9.6e-06 25.5 10.5 1.6e-05 24.8 7.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO24825.1 - 0.00091 19.0 9.6 0.0015 18.2 6.7 1.4 1 0 0 1 1 1 1 Ring finger domain PDZ PF00595.19 KOO24825.1 - 0.03 14.4 0.0 0.065 13.4 0.0 1.5 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) zf-RING_5 PF14634.1 KOO24825.1 - 0.078 12.7 9.6 0.14 11.8 6.7 1.4 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.1 KOO24825.1 - 4.6 6.8 10.2 27 4.4 0.1 3.2 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 NT-C2 PF10358.4 KOO24826.1 - 2.7e-11 43.1 0.0 3.8e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins Cnd2 PF05786.9 KOO24827.1 - 5.3e-35 121.1 2.4 2.4e-10 39.6 1.1 4.4 2 2 2 4 4 4 4 Condensin complex subunit 2 Trypan_PARP PF05887.6 KOO24827.1 - 0.0098 15.7 26.0 0.0098 15.7 18.0 3.1 3 0 0 3 3 3 1 Procyclic acidic repetitive protein (PARP) Phage_Gp14 PF10666.4 KOO24827.1 - 0.086 12.7 2.3 0.45 10.3 0.2 2.2 2 0 0 2 2 2 0 Phage protein Gp14 Acyltransferase PF01553.16 KOO24828.1 - 9.5e-19 67.1 0.0 1e-09 37.9 0.0 2.3 2 0 0 2 2 2 2 Acyltransferase DUF3552 PF12072.3 KOO24831.1 - 0.0045 16.2 4.5 0.0052 16.0 3.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) Tektin PF03148.9 KOO24831.1 - 0.02 13.4 4.3 0.021 13.3 3.0 1.1 1 0 0 1 1 1 0 Tektin family DUF4200 PF13863.1 KOO24831.1 - 0.032 14.1 7.8 0.04 13.8 5.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) DUF939_C PF11728.3 KOO24831.1 - 0.037 13.8 1.7 0.046 13.5 1.1 1.0 1 0 0 1 1 1 0 DUF939 C-terminal domain DUF4404 PF14357.1 KOO24831.1 - 0.058 13.8 2.9 0.084 13.2 2.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) Fez1 PF06818.10 KOO24831.1 - 0.062 13.3 4.1 0.069 13.1 2.8 1.0 1 0 0 1 1 1 0 Fez1 Laminin_II PF06009.7 KOO24831.1 - 0.071 12.8 0.3 0.071 12.8 0.2 1.6 2 0 0 2 2 2 0 Laminin Domain II F420_ligase PF01996.11 KOO24831.1 - 0.1 11.6 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 F420-0:Gamma-glutamyl ligase PVL_ORF50 PF07768.6 KOO24831.1 - 0.13 12.2 2.5 0.15 12.0 1.7 1.1 1 0 0 1 1 1 0 PVL ORF-50-like family KxDL PF10241.4 KOO24831.1 - 0.28 11.1 2.7 0.59 10.0 1.9 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein MCC-bdg_PDZ PF10506.4 KOO24831.1 - 0.32 10.8 7.6 0.78 9.6 0.6 2.6 1 1 1 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Spc7 PF08317.6 KOO24831.1 - 0.35 9.4 5.2 0.39 9.3 3.6 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein Atg14 PF10186.4 KOO24831.1 - 0.42 9.5 3.3 0.46 9.3 2.3 1.0 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 IncA PF04156.9 KOO24831.1 - 0.62 9.6 6.5 0.74 9.3 4.5 1.1 1 0 0 1 1 1 0 IncA protein Ank_2 PF12796.2 KOO24832.1 - 3e-32 110.7 0.1 5.2e-16 58.7 0.0 4.5 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO24832.1 - 3.9e-25 87.3 6.2 3.6e-07 30.2 0.1 4.8 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.25 KOO24832.1 - 1.2e-24 84.8 12.0 7.1e-07 28.7 0.0 7.4 8 0 0 8 8 8 5 Ankyrin repeat Ank_4 PF13637.1 KOO24832.1 - 1.1e-19 70.3 3.0 0.00054 20.4 0.0 6.3 2 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO24832.1 - 8.9e-12 44.0 3.6 0.3 11.4 0.0 7.2 7 1 0 7 7 7 4 Ankyrin repeat Methyltransf_21 PF05050.7 KOO24834.1 - 1.8e-09 37.7 0.0 2.9e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase FkbM domain Phospholip_B PF04916.8 KOO24835.1 - 4.5e-127 424.4 0.1 6.1e-127 424.0 0.1 1.1 1 0 0 1 1 1 1 Phospholipase B Pkinase PF00069.20 KOO24836.1 - 5.3e-19 68.3 0.9 8.7e-19 67.6 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO24836.1 - 1.7e-18 66.6 0.0 4.4e-18 65.2 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Borrelia_P83 PF05262.6 KOO24836.1 - 0.012 13.9 4.1 0.039 12.2 3.5 1.4 2 0 0 2 2 2 0 Borrelia P83/100 protein NARP1 PF12569.3 KOO24836.1 - 0.032 12.9 14.7 0.059 12.1 10.2 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 RR_TM4-6 PF06459.7 KOO24836.1 - 0.82 9.5 8.3 1.2 9.0 5.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TraV PF09676.5 KOO24836.1 - 7.2 7.3 12.1 16 6.2 8.4 1.6 1 1 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) zf-RING_2 PF13639.1 KOO24837.1 - 3.9e-13 49.0 5.0 6.3e-13 48.3 3.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 KOO24837.1 - 5.7e-08 32.2 3.7 9.3e-08 31.6 2.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO24837.1 - 1.1e-06 28.5 5.2 1.9e-06 27.8 3.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 KOO24837.1 - 3e-06 27.2 4.1 7.8e-06 25.9 2.8 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 KOO24837.1 - 1.8e-05 24.3 3.3 2.8e-05 23.7 2.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 KOO24837.1 - 1.9e-05 24.2 2.8 2.9e-05 23.6 2.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 KOO24837.1 - 0.011 15.5 3.2 0.027 14.3 2.2 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF2586 PF10758.4 KOO24837.1 - 0.015 14.3 1.0 0.021 13.8 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2586) zf-C3HC4_4 PF15227.1 KOO24837.1 - 0.023 14.5 4.8 0.04 13.8 3.3 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING-like PF08746.6 KOO24837.1 - 0.038 13.9 3.6 0.062 13.3 2.5 1.3 1 0 0 1 1 1 0 RING-like domain AAA_13 PF13166.1 KOO24837.1 - 0.044 12.2 2.0 0.06 11.7 1.4 1.1 1 0 0 1 1 1 0 AAA domain zf-RING_4 PF14570.1 KOO24837.1 - 0.066 12.8 2.9 0.15 11.6 2.0 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.2 KOO24837.1 - 0.18 11.8 3.3 0.52 10.4 2.2 1.8 1 1 0 1 1 1 0 RING-variant domain FANCL_C PF11793.3 KOO24837.1 - 0.19 11.7 4.3 0.75 9.7 3.0 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain DUF2422 PF10337.4 KOO24837.1 - 0.66 8.6 2.0 0.85 8.3 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) AAA PF00004.24 KOO24839.1 - 5.4e-39 133.4 0.0 8.2e-39 132.8 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO24839.1 - 1.7e-06 28.1 0.7 2.5e-05 24.3 0.5 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 KOO24839.1 - 6.1e-06 26.4 0.1 0.00047 20.3 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 KOO24839.1 - 6.1e-05 22.9 0.0 0.00014 21.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.12 KOO24839.1 - 6.3e-05 22.4 0.0 0.00011 21.6 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.1 KOO24839.1 - 0.00035 20.2 0.2 0.0017 18.0 0.1 2.2 2 0 0 2 2 2 1 Part of AAA domain Shugoshin_C PF07557.6 KOO24839.1 - 0.00063 19.1 0.1 0.0019 17.5 0.0 1.9 1 0 0 1 1 1 1 Shugoshin C terminus AAA_30 PF13604.1 KOO24839.1 - 0.0018 17.8 0.0 0.0052 16.3 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_17 PF13207.1 KOO24839.1 - 0.002 18.9 0.1 0.0047 17.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain Sigma54_activ_2 PF14532.1 KOO24839.1 - 0.0021 18.1 0.0 0.0042 17.1 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.9 KOO24839.1 - 0.0021 17.7 0.1 0.0093 15.6 0.0 2.2 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 KOO24839.1 - 0.0025 17.6 0.0 0.0047 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 KOO24839.1 - 0.0027 16.8 0.0 0.028 13.4 0.0 2.0 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Agenet PF05641.7 KOO24839.1 - 0.005 16.9 0.1 0.012 15.7 0.0 1.7 1 1 0 1 1 1 1 Agenet domain AAA_28 PF13521.1 KOO24839.1 - 0.0079 16.1 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOO24839.1 - 0.0098 16.1 0.0 0.018 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 KOO24839.1 - 0.014 14.7 0.2 0.046 13.1 0.1 1.8 1 1 1 2 2 2 0 AAA domain TIP49 PF06068.8 KOO24839.1 - 0.017 13.8 0.0 0.024 13.3 0.0 1.1 1 0 0 1 1 1 0 TIP49 C-terminus Mg_chelatase PF01078.16 KOO24839.1 - 0.021 14.0 0.1 0.037 13.1 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF2075 PF09848.4 KOO24839.1 - 0.037 13.0 0.0 0.05 12.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ResIII PF04851.10 KOO24839.1 - 0.043 13.6 0.0 0.062 13.1 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.17 KOO24839.1 - 0.068 13.3 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 RNA helicase Sigma54_activat PF00158.21 KOO24839.1 - 0.084 12.3 0.0 0.22 10.9 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.7 KOO24839.1 - 0.11 12.1 0.2 0.51 9.9 0.1 2.1 1 1 0 1 1 1 0 NACHT domain Parvo_NS1 PF01057.12 KOO24839.1 - 0.13 11.0 0.0 0.21 10.4 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_11 PF13086.1 KOO24839.1 - 0.14 11.7 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 KOO24839.1 - 0.19 10.9 0.0 0.39 9.9 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein KTI12 PF08433.5 KOO24839.1 - 0.2 10.8 0.0 0.31 10.2 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 zf-RING_2 PF13639.1 KOO24840.1 - 3.9e-13 49.0 5.0 6.3e-13 48.3 3.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 KOO24840.1 - 5.7e-08 32.2 3.7 9.3e-08 31.6 2.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO24840.1 - 1.1e-06 28.5 5.2 1.9e-06 27.8 3.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 KOO24840.1 - 3e-06 27.2 4.1 7.8e-06 25.9 2.8 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 KOO24840.1 - 1.8e-05 24.3 3.3 2.8e-05 23.7 2.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 KOO24840.1 - 1.9e-05 24.2 2.8 2.9e-05 23.6 2.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 KOO24840.1 - 0.011 15.5 3.2 0.027 14.3 2.2 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF2586 PF10758.4 KOO24840.1 - 0.015 14.3 1.0 0.021 13.8 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2586) zf-C3HC4_4 PF15227.1 KOO24840.1 - 0.023 14.5 4.8 0.04 13.8 3.3 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING-like PF08746.6 KOO24840.1 - 0.038 13.9 3.6 0.062 13.3 2.5 1.3 1 0 0 1 1 1 0 RING-like domain AAA_13 PF13166.1 KOO24840.1 - 0.044 12.2 2.0 0.06 11.7 1.4 1.1 1 0 0 1 1 1 0 AAA domain zf-RING_4 PF14570.1 KOO24840.1 - 0.066 12.8 2.9 0.15 11.6 2.0 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.2 KOO24840.1 - 0.18 11.8 3.3 0.52 10.4 2.2 1.8 1 1 0 1 1 1 0 RING-variant domain FANCL_C PF11793.3 KOO24840.1 - 0.19 11.7 4.3 0.75 9.7 3.0 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain DUF2422 PF10337.4 KOO24840.1 - 0.66 8.6 2.0 0.85 8.3 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) AAA PF00004.24 KOO24842.1 - 6.4e-39 133.1 0.0 1e-38 132.5 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO24842.1 - 5.3e-06 26.5 2.3 3.1e-05 24.0 0.5 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 KOO24842.1 - 8.2e-06 25.9 0.1 0.00057 20.0 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 KOO24842.1 - 7.4e-05 22.7 0.0 0.00017 21.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.12 KOO24842.1 - 7.5e-05 22.2 0.0 0.00013 21.4 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.1 KOO24842.1 - 0.00042 19.9 0.2 0.002 17.8 0.1 2.2 2 0 0 2 2 2 1 Part of AAA domain Shugoshin_C PF07557.6 KOO24842.1 - 0.00071 18.9 0.1 0.0022 17.4 0.0 1.9 1 0 0 1 1 1 1 Shugoshin C terminus AAA_30 PF13604.1 KOO24842.1 - 0.0022 17.5 0.0 0.006 16.1 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_17 PF13207.1 KOO24842.1 - 0.0023 18.7 0.1 0.0056 17.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain Sigma54_activ_2 PF14532.1 KOO24842.1 - 0.0024 17.9 0.0 0.0049 16.9 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.9 KOO24842.1 - 0.0028 17.3 0.1 0.011 15.4 0.0 2.2 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 KOO24842.1 - 0.0028 17.5 0.0 0.0057 16.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 KOO24842.1 - 0.0035 16.4 0.0 0.034 13.1 0.0 2.0 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Agenet PF05641.7 KOO24842.1 - 0.0056 16.8 0.1 0.015 15.4 0.0 1.8 1 1 0 1 1 1 1 Agenet domain AAA_28 PF13521.1 KOO24842.1 - 0.0092 15.9 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOO24842.1 - 0.011 15.9 0.0 0.021 15.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 KOO24842.1 - 0.017 14.5 0.2 0.056 12.8 0.1 1.7 1 1 0 1 1 1 0 AAA domain TIP49 PF06068.8 KOO24842.1 - 0.018 13.7 0.0 0.028 13.1 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus Mg_chelatase PF01078.16 KOO24842.1 - 0.024 13.8 0.1 0.042 13.0 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF2075 PF09848.4 KOO24842.1 - 0.042 12.8 0.0 0.058 12.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ResIII PF04851.10 KOO24842.1 - 0.05 13.4 0.0 0.075 12.8 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.17 KOO24842.1 - 0.077 13.1 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.7 KOO24842.1 - 0.089 12.4 0.3 0.63 9.6 0.1 2.4 2 1 0 2 2 2 0 NACHT domain Sigma54_activat PF00158.21 KOO24842.1 - 0.1 12.0 0.0 0.25 10.7 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_10 PF12846.2 KOO24842.1 - 0.13 11.6 0.0 0.32 10.3 0.0 1.7 1 1 0 1 1 1 0 AAA-like domain Parvo_NS1 PF01057.12 KOO24842.1 - 0.15 10.9 0.0 0.24 10.2 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_11 PF13086.1 KOO24842.1 - 0.16 11.5 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.5 KOO24842.1 - 0.22 10.6 0.0 0.36 10.0 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 PhoH PF02562.11 KOO24842.1 - 0.23 10.6 0.0 0.45 9.7 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Agenet PF05641.7 KOO24843.1 - 1.1e-14 54.3 4.2 1.4e-07 31.5 0.1 4.3 3 1 1 4 4 4 3 Agenet domain PP2C PF00481.16 KOO24844.1 - 2.8e-28 99.0 0.0 3.6e-28 98.6 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOO24844.1 - 5e-10 39.4 0.2 1.9e-08 34.2 0.1 2.2 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 KOO24844.1 - 0.0003 20.2 0.0 0.00069 19.0 0.0 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C Glyco_trans_1_3 PF13528.1 KOO24845.1 - 3e-11 43.0 0.0 1.1e-10 41.2 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferase family 1 GHMP_kinases_N PF00288.21 KOO24845.1 - 4.6e-10 39.4 0.9 1.7e-09 37.5 0.6 2.1 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 KOO24845.1 - 2.9e-08 33.7 0.1 1.4e-07 31.6 0.1 2.2 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.4 KOO24845.1 - 3.1e-07 29.5 0.2 9.4e-06 24.8 0.0 2.9 3 0 0 3 3 3 1 Galactokinase galactose-binding signature DUF3847 PF12958.2 KOO24845.1 - 0.062 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3847) DUF1551 PF07585.6 KOO24845.1 - 0.26 10.1 0.0 0.44 9.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1551) Rotamase PF00639.16 KOO24846.1 - 9.3e-18 64.7 0.0 1.3e-17 64.3 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 KOO24846.1 - 1.6e-13 50.9 0.0 2.4e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 KOO24846.1 - 0.0022 18.6 0.0 0.0029 18.2 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Cys_rich_FGFR PF00839.12 KOO24847.1 - 0.0016 18.2 5.6 0.0028 17.5 0.0 2.6 2 1 0 2 2 2 1 Cysteine rich repeat DUF3893 PF13032.1 KOO24847.1 - 0.0058 16.7 0.3 0.0089 16.1 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3893) Med19 PF10278.4 KOO24847.1 - 0.29 10.7 5.0 0.43 10.2 3.4 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 YkyA PF10368.4 KOO24847.1 - 2.4 7.4 13.9 4.3 6.6 9.6 1.3 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein IQ PF00612.22 KOO24848.1 - 4.7e-09 35.0 18.4 0.0094 15.5 0.1 5.4 5 0 0 5 5 5 5 IQ calmodulin-binding motif CDK5_activator PF03261.10 KOO24848.1 - 0.33 10.2 5.7 0.42 9.8 4.0 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein PAT1 PF09770.4 KOO24848.1 - 4.7 5.3 24.9 6.1 4.9 17.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Tropomyosin PF00261.15 KOO24849.1 - 0.015 14.3 0.1 0.02 13.9 0.0 1.1 1 0 0 1 1 1 0 Tropomyosin Eclosion PF04736.7 KOO24849.1 - 0.1 12.0 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 Eclosion hormone EF-hand_1 PF00036.27 KOO24850.1 - 3.9e-08 32.0 0.1 0.00058 18.9 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO24850.1 - 1.6e-07 30.3 1.4 5.3e-05 22.3 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO24850.1 - 3.3e-07 29.6 0.2 0.0021 17.7 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO24850.1 - 1.1e-05 24.9 0.1 0.0062 16.1 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.1 KOO24850.1 - 1.5e-05 25.0 0.1 0.042 13.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair DUF1079 PF06435.6 KOO24850.1 - 0.15 12.0 0.2 0.51 10.3 0.0 1.9 2 1 1 3 3 3 0 Repeat of unknown function (DUF1079) FA_desaturase PF00487.19 KOO24852.1 - 2.7e-30 105.6 14.9 6.8e-30 104.3 10.4 1.6 1 1 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.5 KOO24852.1 - 2.9e-17 61.6 0.1 5e-17 60.8 0.1 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) Ank_2 PF12796.2 KOO24853.1 - 3.5e-78 258.0 23.0 8.3e-15 54.9 0.2 9.5 2 1 6 9 9 9 9 Ankyrin repeats (3 copies) Ank PF00023.25 KOO24853.1 - 4.5e-62 202.9 40.5 2.6e-07 30.0 0.1 18.0 18 0 0 18 18 18 14 Ankyrin repeat Ank_4 PF13637.1 KOO24853.1 - 4.5e-60 199.0 17.5 5.2e-08 33.1 0.0 13.3 6 4 8 14 14 14 13 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO24853.1 - 3.4e-55 182.8 31.4 2.2e-08 34.0 0.3 14.0 6 5 8 14 14 14 11 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO24853.1 - 1.2e-44 145.7 20.3 1.1e-06 28.3 0.0 18.1 19 0 0 19 19 19 9 Ankyrin repeat FYVE PF01363.16 KOO24853.1 - 6.3e-14 51.6 15.2 1.2e-13 50.7 10.6 1.5 1 0 0 1 1 1 1 FYVE zinc finger BTB PF00651.26 KOO24853.1 - 0.028 14.3 0.0 0.07 13.1 0.0 1.6 1 0 0 1 1 1 0 BTB/POZ domain zf-DHHC PF01529.15 KOO24853.1 - 0.23 10.8 5.3 0.51 9.7 3.7 1.5 1 0 0 1 1 1 0 DHHC palmitoyltransferase NMD3 PF04981.8 KOO24853.1 - 4.4 6.3 11.9 1.7 7.7 2.9 2.2 1 1 1 2 2 2 0 NMD3 family VWA_2 PF13519.1 KOO24855.1 - 0.0012 18.9 0.0 0.0016 18.5 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 KOO24855.1 - 0.1 12.3 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 von Willebrand factor type A domain GHMP_kinases_C PF08544.8 KOO24857.1 - 2e-06 27.9 0.0 4.9e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal NTP_transferase PF00483.18 KOO24857.1 - 3.3e-06 26.5 0.0 5.6e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase GHMP_kinases_N PF00288.21 KOO24857.1 - 3.4e-05 23.8 0.0 7.6e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GLYCAM-1 PF05242.6 KOO24858.1 - 0.002 18.0 1.3 0.0053 16.6 0.9 1.8 1 0 0 1 1 1 1 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) EF-hand_7 PF13499.1 KOO24858.1 - 0.019 15.0 0.0 0.053 13.6 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.27 KOO24858.1 - 0.038 13.3 0.0 0.59 9.5 0.0 2.5 2 0 0 2 2 2 0 EF hand EF-hand_5 PF13202.1 KOO24858.1 - 0.11 11.8 0.1 2.8 7.4 0.0 2.5 2 0 0 2 2 2 0 EF hand EF-hand_8 PF13833.1 KOO24858.1 - 0.13 11.9 0.0 0.42 10.2 0.0 1.9 1 1 0 1 1 1 0 EF-hand domain pair Phage_GP20 PF06810.6 KOO24858.1 - 0.91 8.9 5.4 10 5.5 0.1 2.4 1 1 1 2 2 2 0 Phage minor structural protein GP20 PPTA PF01239.17 KOO24859.1 - 2.7e-36 121.4 9.4 1.7e-08 33.4 0.0 6.2 6 0 0 6 6 6 6 Protein prenyltransferase alpha subunit repeat PEMT PF04191.8 KOO24861.1 - 7.8e-10 38.8 1.2 1.9e-09 37.6 0.8 1.7 1 1 0 1 1 1 1 Phospholipid methyltransferase ICMT PF04140.9 KOO24861.1 - 0.00012 22.1 0.2 0.00025 21.1 0.0 1.6 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF1295 PF06966.7 KOO24861.1 - 0.0044 16.3 1.5 0.0065 15.7 1.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) ERG4_ERG24 PF01222.12 KOO24861.1 - 0.017 13.7 0.1 0.019 13.5 0.1 1.2 1 0 0 1 1 1 0 Ergosterol biosynthesis ERG4/ERG24 family DUF3040 PF11239.3 KOO24861.1 - 0.22 11.5 1.8 1.8 8.6 0.4 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) DUF2237 PF09996.4 KOO24862.1 - 9.3e-16 57.3 1.3 2.4e-15 56.0 0.9 1.7 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2237) adh_short PF00106.20 KOO24864.1 - 5.5e-15 55.6 1.0 1.2e-14 54.5 0.7 1.6 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOO24864.1 - 0.0083 15.8 1.1 0.038 13.6 0.8 1.9 1 1 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 KOO24864.1 - 0.025 14.3 0.0 0.035 13.8 0.0 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase WD40 PF00400.27 KOO24865.1 - 0.23 11.4 0.0 0.23 11.4 0.0 5.4 7 0 0 7 7 7 0 WD domain, G-beta repeat tRNA-synt_1c PF00749.16 KOO24868.1 - 7.6e-84 281.0 0.0 9.9e-84 280.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain Tropomyosin_1 PF12718.2 KOO24869.1 - 0.0026 17.6 13.6 0.0026 17.6 9.4 4.5 1 1 2 4 4 4 2 Tropomyosin like NYD-SP28_assoc PF14775.1 KOO24869.1 - 0.013 15.2 1.9 0.013 15.2 1.3 4.2 3 0 0 3 3 3 0 Sperm tail C-terminal domain V_ATPase_I PF01496.14 KOO24869.1 - 0.59 7.9 38.7 0.074 10.9 8.2 3.2 1 1 2 3 3 3 0 V-type ATPase 116kDa subunit family AAA_13 PF13166.1 KOO24869.1 - 0.84 8.0 54.1 0.69 8.2 4.9 3.2 1 1 2 3 3 3 0 AAA domain VPS9 PF02204.13 KOO24871.1 - 2.1e-20 72.6 0.0 3.6e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain FBPase PF00316.15 KOO24872.1 - 7.6e-70 235.3 0.0 9.5e-70 234.9 0.0 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase NUDIX PF00293.23 KOO24873.1 - 0.0022 17.6 0.1 0.0075 15.9 0.1 1.9 1 1 0 1 1 1 1 NUDIX domain SEP PF08059.8 KOO24874.1 - 5.9e-24 84.1 0.0 1.3e-23 83.0 0.0 1.6 1 0 0 1 1 1 1 SEP domain UBX PF00789.15 KOO24874.1 - 7.6e-09 35.5 0.0 1.2e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 UBX domain cwf21 PF08312.7 KOO24876.1 - 1.3e-15 56.9 4.9 1.3e-15 56.9 3.4 2.7 2 1 0 2 2 2 1 cwf21 domain PDZ_2 PF13180.1 KOO24876.1 - 0.00021 21.0 0.3 0.00081 19.2 0.1 2.0 1 1 1 2 2 2 1 PDZ domain PDZ PF00595.19 KOO24876.1 - 0.00092 19.3 0.1 0.0027 17.8 0.0 1.8 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) E3_binding PF02817.12 KOO24876.1 - 0.03 13.9 2.8 0.035 13.7 0.1 2.6 2 0 0 2 2 2 0 e3 binding domain RNase_H2-Ydr279 PF09468.5 KOO24876.1 - 4.8 6.2 22.0 0.025 13.8 5.4 2.2 2 0 0 2 2 2 0 Ydr279p protein family (RNase H2 complex component) SAM_1 PF00536.25 KOO24877.1 - 3.7e-20 71.8 0.0 5.3e-10 39.3 0.0 2.2 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 KOO24877.1 - 9.6e-20 70.2 0.0 9.4e-11 41.4 0.0 2.2 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_PNT PF02198.11 KOO24877.1 - 3.1e-06 26.8 0.0 0.02 14.6 0.0 2.6 1 1 0 2 2 2 2 Sterile alpha motif (SAM)/Pointed domain DUF3509 PF12021.3 KOO24877.1 - 0.053 13.2 0.0 1.9 8.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3509) Pro-kuma_activ PF09286.6 KOO24877.1 - 0.14 12.1 0.1 4.5 7.3 0.0 2.2 1 1 0 2 2 2 0 Pro-kumamolisin, activation domain Ank_2 PF12796.2 KOO24878.1 - 5.6e-44 148.3 17.0 3.3e-13 49.7 0.4 5.5 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO24878.1 - 1.8e-31 107.9 13.3 5.6e-08 33.0 0.1 7.8 4 3 3 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.25 KOO24878.1 - 2.3e-31 105.9 25.4 0.00019 21.0 0.0 9.9 10 0 0 10 10 10 9 Ankyrin repeat Ank_5 PF13857.1 KOO24878.1 - 7.2e-25 86.4 18.0 2.4e-06 27.5 0.3 7.3 3 2 5 8 8 8 8 Ankyrin repeats (many copies) Rad10 PF03834.9 KOO24878.1 - 2.1e-20 72.1 0.0 3.7e-20 71.3 0.0 1.4 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) Dev_Cell_Death PF10539.4 KOO24878.1 - 7.8e-18 64.2 0.0 1.4e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 Development and cell death domain Ank_3 PF13606.1 KOO24878.1 - 1e-15 56.2 14.3 0.012 15.7 0.0 10.2 11 0 0 11 11 11 3 Ankyrin repeat HHH_2 PF12826.2 KOO24878.1 - 0.039 13.8 0.0 0.2 11.5 0.0 2.3 1 0 0 1 1 1 0 Helix-hairpin-helix motif Trypsin_2 PF13365.1 KOO24878.1 - 0.075 13.0 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 Trypsin-like peptidase domain PDZ PF00595.19 KOO24879.1 - 9.1e-08 32.1 0.0 1.8e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO24879.1 - 0.00022 21.0 0.0 0.00044 20.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain CRISPR_Cse2 PF09485.5 KOO24879.1 - 0.016 15.2 3.3 0.024 14.6 0.8 2.2 3 0 0 3 3 3 0 CRISPR-associated protein Cse2 (CRISPR_cse2) DnaJ_CXXCXGXG PF00684.14 KOO24880.1 - 0.0002 21.3 15.5 0.012 15.6 10.8 2.4 1 1 0 1 1 1 1 DnaJ central domain FpoO PF10621.4 KOO24880.1 - 0.042 13.9 1.2 0.067 13.2 0.8 1.3 1 0 0 1 1 1 0 F420H2 dehydrogenase subunit FpoO PyrI_C PF02748.10 KOO24880.1 - 0.12 11.8 1.8 0.13 11.7 0.1 1.9 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-B_box PF00643.19 KOO24880.1 - 2.7 7.9 5.9 15 5.5 0.4 2.3 2 0 0 2 2 2 0 B-box zinc finger Prim_Zn_Ribbon PF08273.7 KOO24880.1 - 3.5 7.7 13.0 7.4 6.7 0.2 3.0 2 1 0 2 2 2 0 Zinc-binding domain of primase-helicase DUF1356 PF07092.7 KOO24880.1 - 8.5 5.4 9.1 3.4 6.8 1.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1356) TFIIF_alpha PF05793.7 KOO24881.1 - 4.9e-13 48.3 18.7 2.7e-12 45.8 12.9 1.8 1 1 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Sin_N PF04801.8 KOO24881.1 - 1.4 7.7 5.1 6.6 5.4 1.0 2.5 3 0 0 3 3 3 0 Sin-like protein conserved region EF-hand_1 PF00036.27 KOO24882.1 - 5.2e-16 56.6 0.1 8.3e-08 31.0 0.0 2.1 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO24882.1 - 1.3e-13 50.3 1.1 9.6e-11 41.1 0.2 1.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO24882.1 - 3.9e-12 44.9 0.1 1e-05 24.9 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO24882.1 - 6.8e-12 45.3 0.2 8.7e-12 45.0 0.1 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO24882.1 - 5.2e-11 41.3 0.1 0.00036 19.7 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.1 KOO24882.1 - 2.1e-06 27.2 0.2 0.00013 21.5 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.2 KOO24882.1 - 0.0011 18.6 0.0 0.27 10.9 0.0 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand TerB PF05099.8 KOO24882.1 - 0.0025 17.5 0.0 0.0039 16.9 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TerB SPARC_Ca_bdg PF10591.4 KOO24882.1 - 0.01 15.8 0.1 0.27 11.2 0.0 2.1 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Amino_oxidase PF01593.19 KOO24883.1 - 7e-20 71.5 0.0 1.2e-19 70.7 0.0 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 KOO24883.1 - 6.1e-12 45.3 0.4 1.6e-11 44.0 0.3 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 KOO24883.1 - 1.7e-07 30.4 1.7 3.6e-07 29.3 1.2 1.5 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 KOO24883.1 - 3.2e-07 29.5 0.1 4.5e-07 29.0 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 KOO24883.1 - 1.3e-06 27.1 0.4 1.9e-06 26.6 0.3 1.2 1 0 0 1 1 1 1 HI0933-like protein SWIRM PF04433.12 KOO24883.1 - 1.9e-06 27.8 0.0 4.2e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 SWIRM domain Pyr_redox_2 PF07992.9 KOO24883.1 - 3.1e-06 27.2 0.4 5.7e-06 26.3 0.2 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 KOO24883.1 - 3.8e-06 26.2 0.5 5.2e-06 25.8 0.4 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 KOO24883.1 - 1.5e-05 25.1 0.7 6.2e-05 23.1 0.5 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 KOO24883.1 - 2.6e-05 23.4 0.2 3.5e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.16 KOO24883.1 - 0.00011 21.8 0.6 0.00022 20.8 0.4 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.12 KOO24883.1 - 0.00029 20.0 0.1 0.00051 19.1 0.1 1.3 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.17 KOO24883.1 - 0.0014 17.5 0.9 0.002 17.0 0.6 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.22 KOO24883.1 - 0.0017 18.7 0.8 0.0033 17.8 0.6 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase YjeF_N PF03853.10 KOO24883.1 - 0.022 14.3 0.5 0.054 13.1 0.4 1.6 1 0 0 1 1 1 0 YjeF-related protein N-terminus Shikimate_DH PF01488.15 KOO24883.1 - 0.033 14.3 0.4 0.053 13.6 0.3 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Rossmann-like PF10727.4 KOO24883.1 - 0.038 13.7 1.2 0.088 12.5 0.9 1.5 1 0 0 1 1 1 0 Rossmann-like domain Lycopene_cycl PF05834.7 KOO24883.1 - 0.039 12.8 0.2 0.062 12.2 0.2 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein 2-Hacid_dh_C PF02826.14 KOO24883.1 - 0.052 12.7 0.2 0.11 11.7 0.1 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.13 KOO24883.1 - 0.084 12.8 0.6 0.18 11.7 0.1 1.8 2 0 0 2 2 1 0 TrkA-N domain ApbA PF02558.11 KOO24883.1 - 0.33 10.3 1.5 0.79 9.1 0.9 1.7 1 1 1 2 2 2 0 Ketopantoate reductase PanE/ApbA zf-C2H2_4 PF13894.1 KOO24883.1 - 0.46 10.9 6.6 0.42 11.0 2.9 2.3 2 0 0 2 2 1 0 C2H2-type zinc finger Amino_oxidase PF01593.19 KOO24884.1 - 3e-51 174.8 0.5 3e-51 174.8 0.3 1.3 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase ISG65-75 PF11727.3 KOO24884.1 - 0.95 8.4 4.8 1.4 7.8 3.3 1.2 1 0 0 1 1 1 0 Invariant surface glycoprotein Metal_resist PF13801.1 KOO24884.1 - 1.2 9.1 17.8 1.3 9.0 10.3 2.5 2 1 0 2 2 2 0 Heavy-metal resistance TMEM107 PF14995.1 KOO24885.1 - 5.1e-16 58.9 8.6 6e-16 58.7 6.0 1.0 1 0 0 1 1 1 1 Transmembrane protein DUF1270 PF06900.6 KOO24885.1 - 0.27 11.4 7.0 7.8 6.7 2.0 3.0 1 1 1 3 3 3 0 Protein of unknown function (DUF1270) DUF1145 PF06611.7 KOO24885.1 - 1.7 8.3 6.7 3 7.5 1.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1145) Reticulon PF02453.12 KOO24885.1 - 1.9 8.0 8.8 0.22 11.1 0.2 2.4 1 1 1 2 2 2 0 Reticulon Anoctamin PF04547.7 KOO24886.1 - 3.7e-99 332.4 3.1 4.6e-99 332.0 2.2 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Gly_transf_sug PF04488.10 KOO24886.1 - 4.5e-07 30.2 0.0 1.1e-06 28.9 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif DUF4201 PF13870.1 KOO24887.1 - 7.8e-42 142.7 26.7 7.8e-42 142.7 18.5 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF4201) DUF1664 PF07889.7 KOO24887.1 - 0.0073 16.1 1.1 0.0073 16.1 0.8 3.5 1 1 1 3 3 3 2 Protein of unknown function (DUF1664) COG5 PF10392.4 KOO24887.1 - 3.8 7.4 18.8 1.2 9.0 7.4 3.0 1 1 1 3 3 3 0 Golgi transport complex subunit 5 RRM_3 PF08777.6 KOO24888.1 - 0.00022 21.0 0.0 0.00049 19.9 0.0 1.6 2 0 0 2 2 2 1 RNA binding motif Prothymosin PF03247.9 KOO24888.1 - 0.033 14.3 7.1 0.04 14.0 4.9 1.1 1 0 0 1 1 1 0 Prothymosin/parathymosin family Paf1 PF03985.8 KOO24888.1 - 0.67 8.6 2.6 0.75 8.4 1.8 1.0 1 0 0 1 1 1 0 Paf1 Dynein_heavy PF03028.10 KOO24889.1 - 1.1e-192 641.8 0.0 2.8e-188 627.3 0.0 4.1 2 1 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.8 KOO24889.1 - 1.5e-123 412.3 9.4 4.1e-123 410.9 0.3 4.0 5 0 0 5 5 5 2 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 KOO24889.1 - 2.5e-98 328.2 0.0 4.4e-98 327.4 0.0 1.4 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.2 KOO24889.1 - 2.8e-75 252.7 0.0 5.6e-75 251.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 MT PF12777.2 KOO24889.1 - 2e-49 168.1 14.6 2e-49 168.1 10.1 1.6 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_9 PF12781.2 KOO24889.1 - 7.5e-48 162.3 4.9 1.3e-46 158.3 2.3 3.1 2 1 0 2 2 2 1 ATP-binding dynein motor region D5 AAA_7 PF12775.2 KOO24889.1 - 1.1e-43 149.2 0.0 3.7e-35 121.3 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region D3 AAA_5 PF07728.9 KOO24889.1 - 2.1e-19 69.6 0.0 1.1e-05 25.1 0.0 5.6 5 1 0 5 5 5 3 AAA domain (dynein-related subfamily) DHC_N1 PF08385.7 KOO24889.1 - 7.1e-17 61.0 8.0 3.6e-15 55.3 0.0 3.6 3 1 0 3 3 3 2 Dynein heavy chain, N-terminal region 1 AAA_16 PF13191.1 KOO24889.1 - 6.7e-06 26.2 2.4 0.7 9.8 0.0 5.0 4 1 1 5 5 5 2 AAA ATPase domain AAA PF00004.24 KOO24889.1 - 3.2e-05 24.1 1.7 0.55 10.4 0.0 4.5 5 0 0 5 5 4 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOO24889.1 - 0.00052 20.1 0.1 0.95 9.6 0.0 3.9 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.1 KOO24889.1 - 0.0021 17.7 0.1 0.35 10.6 0.0 2.7 2 0 0 2 2 2 1 Part of AAA domain AAA_17 PF13207.1 KOO24889.1 - 0.0091 16.8 0.2 0.66 10.8 0.0 4.0 4 0 0 4 4 4 1 AAA domain AAA_18 PF13238.1 KOO24889.1 - 0.024 14.9 0.0 11 6.2 0.0 4.0 3 0 0 3 3 3 0 AAA domain TPT PF03151.11 KOO24890.1 - 1.3e-09 37.8 11.5 1.3e-09 37.8 8.0 3.0 2 1 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 KOO24890.1 - 2.7e-07 29.8 20.7 3.9e-07 29.2 14.4 1.3 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 KOO24890.1 - 5.6e-06 26.4 26.9 0.00017 21.6 6.7 3.1 2 1 0 3 3 3 2 EamA-like transporter family SoxD PF04267.7 KOO24891.1 - 0.88 9.4 7.2 13 5.7 0.1 4.3 3 1 0 3 3 3 0 Sarcosine oxidase, delta subunit family Myb_DNA-binding PF00249.26 KOO24892.1 - 5.6e-14 51.9 0.1 1.1e-13 50.9 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO24892.1 - 8e-09 35.4 0.6 1.5e-08 34.5 0.4 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Ribosomal_S2 PF00318.15 KOO24894.1 - 1e-36 126.1 0.0 1.2e-36 125.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S2 Dpy-30 PF05186.8 KOO24896.1 - 0.077 12.4 0.1 0.22 11.0 0.1 1.8 1 0 0 1 1 1 0 Dpy-30 motif Ank_4 PF13637.1 KOO24897.1 - 1.5e-44 149.5 8.1 1.2e-12 48.0 0.0 6.1 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO24897.1 - 1.6e-44 150.1 3.3 2.4e-19 69.4 0.1 3.5 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 KOO24897.1 - 1.3e-37 125.7 2.0 5.9e-08 32.1 0.0 7.3 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.1 KOO24897.1 - 7.6e-27 90.7 0.1 0.00016 21.5 0.0 7.5 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.1 KOO24897.1 - 2.3e-25 88.0 4.3 5.1e-05 23.3 0.0 7.5 1 1 5 6 6 6 5 Ankyrin repeats (many copies) zf-DHHC PF01529.15 KOO24897.1 - 4.2e-24 84.8 4.8 5e-24 84.6 2.8 1.4 1 1 0 1 1 1 1 DHHC palmitoyltransferase PPR_2 PF13041.1 KOO24898.1 - 0.0055 16.6 0.0 3.3 7.7 0.0 2.5 2 0 0 2 2 2 2 PPR repeat family ECH PF00378.15 KOO24898.1 - 0.043 12.9 0.5 0.075 12.1 0.4 1.4 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase family PPR_3 PF13812.1 KOO24898.1 - 0.099 12.9 4.8 2.7 8.5 0.0 4.6 5 0 0 5 5 5 0 Pentatricopeptide repeat domain PABP PF00658.13 KOO24899.1 - 3.4e-15 55.4 0.1 6.7e-15 54.5 0.1 1.5 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RNA_GG_bind PF10258.4 KOO24899.1 - 3e-11 42.8 0.0 6e-11 41.8 0.0 1.5 1 0 0 1 1 1 1 PHAX RNA-binding domain F-box-like PF12937.2 KOO24899.1 - 0.07 12.8 0.2 0.22 11.2 0.1 1.8 1 0 0 1 1 1 0 F-box-like HALZ PF02183.13 KOO24900.1 - 0.65 9.7 7.4 30 4.4 0.1 3.8 3 0 0 3 3 3 0 Homeobox associated leucine zipper WD40 PF00400.27 KOO24902.1 - 5.3e-37 124.3 10.8 9.2e-11 41.1 0.0 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat bZIP_1 PF00170.16 KOO24902.1 - 0.053 13.4 0.9 0.094 12.6 0.6 1.3 1 0 0 1 1 1 0 bZIP transcription factor CCDC144C PF14915.1 KOO24902.1 - 0.061 12.2 0.9 0.085 11.7 0.7 1.1 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region Herpes_BLRF2 PF05812.7 KOO24902.1 - 0.075 12.8 0.2 0.12 12.1 0.2 1.3 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein TLC PF03219.9 KOO24903.1 - 6.8e-182 605.3 11.0 8.3e-182 605.0 7.6 1.0 1 0 0 1 1 1 1 TLC ATP/ADP transporter MFS_1 PF07690.11 KOO24903.1 - 0.64 8.6 44.2 1.2 7.8 20.6 2.2 1 1 1 2 2 2 0 Major Facilitator Superfamily DoxA PF07680.6 KOO24905.1 - 0.058 13.0 0.0 0.07 12.7 0.0 1.1 1 0 0 1 1 1 0 TQO small subunit DoxA EF-hand_6 PF13405.1 KOO24906.1 - 0.077 12.9 0.9 0.65 10.0 0.0 2.8 3 0 0 3 3 3 0 EF-hand domain EF-hand_5 PF13202.1 KOO24906.1 - 1.4 8.4 4.2 2.2 7.7 0.1 2.9 3 0 0 3 3 3 0 EF hand DUF1155 PF06633.6 KOO24908.1 - 0.36 10.1 2.1 1.4 8.2 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1155) Allexi_40kDa PF05549.6 KOO24909.1 - 0.85 8.8 6.8 2 7.6 0.3 2.2 2 0 0 2 2 2 0 Allexivirus 40kDa protein Cytochrom_C552 PF02335.10 KOO24909.1 - 2.6 6.6 14.3 4.1 5.9 9.9 1.3 1 0 0 1 1 1 0 Cytochrome c552 PLRV_ORF5 PF01690.12 KOO24909.1 - 3.9 6.5 4.6 5.4 6.0 3.2 1.2 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein adh_short PF00106.20 KOO24910.1 - 1.6e-21 76.9 2.7 3.7e-21 75.7 1.8 1.6 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOO24910.1 - 6.7e-13 48.6 0.8 6.7e-13 48.6 0.6 1.5 2 0 0 2 2 2 1 KR domain NAP PF00956.13 KOO24910.1 - 2.4e-06 26.8 0.0 1.2e-05 24.5 0.0 1.9 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) adh_short_C2 PF13561.1 KOO24910.1 - 0.00082 19.2 0.0 0.0013 18.6 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase VWA_CoxE PF05762.9 KOO24910.1 - 0.011 14.8 0.5 0.011 14.8 0.3 1.7 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein Eno-Rase_NADH_b PF12242.3 KOO24910.1 - 0.03 14.1 0.6 0.068 12.9 0.4 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Transglut_core PF01841.14 KOO24911.1 - 0.0002 21.5 0.0 0.00058 20.0 0.0 1.9 1 1 0 1 1 1 1 Transglutaminase-like superfamily GAS PF13851.1 KOO24911.1 - 3.4 6.8 12.5 0.068 12.3 2.6 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF2963 PF11178.3 KOO24911.1 - 6.8 6.1 6.4 2.3 7.7 0.2 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF2963) MIP-T3 PF10243.4 KOO24914.1 - 4.4 5.6 12.6 4.9 5.5 8.7 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 Sulfotransfer_3 PF13469.1 KOO24915.1 - 3e-13 50.9 7.6 3e-13 50.9 5.3 2.5 2 1 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.22 KOO24915.1 - 8.3e-05 21.9 0.0 0.00021 20.6 0.0 1.6 1 1 0 1 1 1 1 Sulfotransferase domain LRR_6 PF13516.1 KOO24916.1 - 1.6e-06 27.5 1.0 0.76 10.0 0.0 3.5 3 0 0 3 3 3 3 Leucine Rich repeat LRR_4 PF12799.2 KOO24916.1 - 1.4e-05 24.5 0.6 0.0082 15.7 0.0 2.3 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO24916.1 - 0.18 12.1 0.4 1.8e+02 3.0 0.0 3.4 3 0 0 3 3 3 0 Leucine rich repeat Romo1 PF10247.4 KOO24917.1 - 1.7e-16 60.1 5.5 7.7e-16 58.0 3.3 2.0 2 0 0 2 2 2 1 Reactive mitochondrial oxygen species modulator 1 EF-hand_1 PF00036.27 KOO24918.1 - 9.2e-24 80.8 6.8 6.1e-06 25.1 0.0 4.7 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.1 KOO24918.1 - 8.4e-22 77.0 4.2 4e-10 39.6 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO24918.1 - 7.3e-21 72.1 5.8 0.0006 19.4 0.1 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO24918.1 - 8.6e-19 65.9 5.7 3.6e-05 22.9 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO24918.1 - 3.7e-15 55.2 2.8 7.2e-06 25.5 0.1 3.8 2 2 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO24918.1 - 3.6e-09 36.6 1.1 0.00021 21.2 0.2 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO24918.1 - 2.9e-05 23.6 0.5 0.27 10.9 0.0 3.0 2 2 2 4 4 4 2 EF hand Toprim_2 PF13155.1 KOO24918.1 - 0.00016 21.8 0.7 0.93 9.8 0.0 3.3 1 1 1 2 2 2 2 Toprim-like Toprim PF01751.17 KOO24918.1 - 0.00056 19.8 7.8 0.069 13.1 1.3 3.4 1 1 1 2 2 2 2 Toprim domain EF-hand_4 PF12763.2 KOO24918.1 - 0.0066 16.1 2.2 0.89 9.3 0.1 3.3 2 2 2 4 4 4 1 Cytoskeletal-regulatory complex EF hand DUF2201 PF09967.4 KOO24918.1 - 0.057 13.4 0.2 13 5.8 0.0 2.6 3 0 0 3 3 3 0 VWA-like domain (DUF2201) PMBR PF09373.5 KOO24918.1 - 0.06 13.3 0.0 1.3 9.1 0.0 2.8 3 0 0 3 3 3 0 Pseudomurein-binding repeat Peptidase_C48 PF02902.14 KOO24919.1 - 4.6e-11 42.7 0.1 2.5e-08 33.8 0.0 2.3 2 0 0 2 2 2 2 Ulp1 protease family, C-terminal catalytic domain Arm PF00514.18 KOO24920.1 - 3.6e-21 74.1 32.1 0.00063 19.4 0.1 8.5 9 1 1 10 10 10 7 Armadillo/beta-catenin-like repeat Ank_2 PF12796.2 KOO24920.1 - 1.6e-12 47.5 2.0 1.9e-12 47.3 0.3 1.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO24920.1 - 1.1e-09 38.5 1.0 1.1e-06 28.9 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO24920.1 - 1.8e-08 34.3 2.0 4.1e-08 33.2 0.7 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.25 KOO24920.1 - 4.6e-07 29.3 6.2 8.9e-05 22.1 0.2 3.7 3 0 0 3 3 3 1 Ankyrin repeat HEAT_2 PF13646.1 KOO24920.1 - 1.1e-05 25.5 41.5 0.032 14.5 3.7 4.7 1 1 2 4 4 4 4 HEAT repeats Ank_3 PF13606.1 KOO24920.1 - 0.00017 21.4 2.9 0.077 13.2 0.1 4.0 3 0 0 3 3 3 1 Ankyrin repeat HEAT PF02985.17 KOO24920.1 - 0.00026 20.7 4.9 0.069 13.2 0.0 5.9 7 0 0 7 7 7 1 HEAT repeat MoaE PF02391.12 KOO24920.1 - 0.008 15.9 0.7 0.45 10.3 0.1 3.2 1 1 1 3 3 3 1 MoaE protein DUF3817 PF12823.2 KOO24920.1 - 0.15 12.4 0.7 45 4.5 0.0 4.2 4 1 1 5 5 5 0 Domain of unknown function (DUF3817) SAM_2 PF07647.12 KOO24921.1 - 6.9e-08 32.2 0.1 1.3e-07 31.3 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 KOO24921.1 - 6.2e-06 26.2 0.1 1.1e-05 25.4 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) YL1 PF05764.8 KOO24922.1 - 1e-31 110.4 16.8 1.3e-31 110.0 11.6 1.1 1 0 0 1 1 1 1 YL1 nuclear protein YL1_C PF08265.6 KOO24922.1 - 4.4e-12 45.3 1.1 1.3e-11 43.8 0.0 2.0 2 0 0 2 2 2 1 YL1 nuclear protein C-terminal domain Daxx PF03344.10 KOO24922.1 - 0.012 14.0 13.9 0.017 13.6 9.6 1.0 1 0 0 1 1 1 0 Daxx Family EF-hand_1 PF00036.27 KOO24923.1 - 1.8e-25 86.2 0.8 1.2e-06 27.3 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO24923.1 - 3.3e-23 81.5 1.2 9e-11 41.7 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO24923.1 - 4.6e-22 77.3 2.1 4.7e-11 42.1 0.1 3.6 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO24923.1 - 4.3e-21 72.8 4.2 2.1e-05 23.9 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO24923.1 - 9.4e-16 56.3 4.6 0.0014 17.8 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_10 PF14788.1 KOO24923.1 - 0.00023 20.7 1.3 0.19 11.4 0.1 3.7 2 2 2 4 4 4 1 EF hand SHIPPO-rpt PF07004.7 KOO24923.1 - 0.002 18.9 13.7 0.71 10.8 1.0 4.7 4 0 0 4 4 4 2 Sperm-tail PG-rich repeat NADPH_Ox PF08414.5 KOO24923.1 - 0.005 16.9 0.1 4.8 7.3 0.0 2.4 2 0 0 2 2 2 2 Respiratory burst NADPH oxidase GCS PF03074.11 KOO24927.1 - 3.5e-130 434.3 0.0 7e-130 433.3 0.0 1.5 1 1 0 1 1 1 1 Glutamate-cysteine ligase WD40 PF00400.27 KOO24928.1 - 7.6e-51 168.2 9.8 3.3e-09 36.2 0.1 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat LisH PF08513.6 KOO24928.1 - 0.006 16.3 0.0 0.037 13.7 0.0 2.2 2 0 0 2 2 2 1 LisH Glyco_hyd_65N_2 PF14498.1 KOO24928.1 - 0.037 13.7 0.1 0.071 12.7 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Nucleoporin_N PF08801.6 KOO24928.1 - 0.13 10.9 0.0 1.5 7.5 0.0 2.1 2 0 0 2 2 2 0 Nup133 N terminal like DEC-1_N PF04625.8 KOO24928.1 - 1.6 7.2 9.5 0.75 8.4 2.1 2.1 2 0 0 2 2 2 0 DEC-1 protein, N-terminal region ADH_N PF08240.7 KOO24931.1 - 6.4e-23 80.5 4.5 6.4e-23 80.5 3.1 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 KOO24931.1 - 5.6e-18 64.7 0.3 1e-17 63.9 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 KOO24931.1 - 4.5e-06 27.5 0.0 1.3e-05 26.1 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glyco_hydro_20 PF00728.17 KOO24932.1 - 6.4e-82 275.5 0.0 8e-82 275.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.1 KOO24932.1 - 2.2e-17 63.9 0.0 3.5e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.10 KOO24932.1 - 5.4e-07 30.1 0.0 9.4e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Metallophos PF00149.23 KOO24933.1 - 3.6e-30 104.8 0.0 7.1e-30 103.9 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KOO24933.1 - 0.0004 20.2 0.0 0.00047 20.0 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain WD40 PF00400.27 KOO24934.1 - 2.6e-52 172.8 16.9 1.2e-12 47.1 0.2 4.2 4 0 0 4 4 4 4 WD domain, G-beta repeat PD40 PF07676.7 KOO24934.1 - 2e-10 40.0 2.1 0.66 9.7 0.0 4.6 4 0 0 4 4 4 4 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOO24934.1 - 3.7e-06 26.7 0.3 0.00057 19.6 0.1 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.1 KOO24934.1 - 2.7e-05 23.4 0.9 0.46 9.5 0.0 3.3 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal rOmpB PF12334.3 KOO24934.1 - 0.002 17.5 2.8 0.27 10.5 0.5 3.0 1 1 1 3 3 3 1 Rickettsia outer membrane protein B Gmad1 PF10647.4 KOO24934.1 - 0.0022 17.4 0.1 5.5 6.3 0.0 3.7 1 1 2 3 3 3 1 Lipoprotein LpqB beta-propeller domain DUF3892 PF13031.1 KOO24934.1 - 0.0042 17.4 1.0 0.89 10.0 0.0 2.5 1 1 2 3 3 3 2 Protein of unknown function (DUF3892) DUF3312 PF11768.3 KOO24934.1 - 0.012 13.9 0.0 0.32 9.1 0.0 2.3 1 1 2 3 3 3 0 Protein of unknown function (DUF3312) LigD_N PF13298.1 KOO24934.1 - 0.054 13.5 0.9 13 5.9 0.0 3.1 1 1 2 3 3 3 0 DNA polymerase Ligase (LigD) SLH PF00395.15 KOO24934.1 - 0.067 12.9 1.8 74 3.2 0.0 4.1 4 0 0 4 4 4 0 S-layer homology domain Proteasome_A_N PF10584.4 KOO24934.1 - 1.4 8.3 5.5 1.4e+02 1.8 0.1 4.0 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature DUF3318 PF11780.3 KOO24936.1 - 0.68 9.4 2.8 0.31 10.5 0.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3318) RRM_6 PF14259.1 KOO24937.1 - 3.6e-61 203.0 0.0 3.9e-15 55.5 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOO24937.1 - 3.6e-33 113.0 0.0 2.6e-08 33.3 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO24937.1 - 1.5e-10 40.7 0.0 0.15 11.8 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4283 PF14111.1 KOO24937.1 - 0.0052 15.8 0.0 7.2 5.6 0.0 3.7 5 0 0 5 5 5 2 Domain of unknown function (DUF4283) Peptidase_S10 PF00450.17 KOO24938.1 - 2.3e-79 267.5 0.0 2.7e-79 267.2 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase CDC14 PF08045.6 KOO24939.1 - 0.088 11.9 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Cell division control protein 14, SIN component DUF2669 PF10876.3 KOO24939.1 - 0.09 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2669) ADPrib_exo_Tox PF03496.9 KOO24940.1 - 2.9e-05 23.3 0.0 5.3e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme ART PF01129.13 KOO24940.1 - 0.00022 20.4 0.0 0.00045 19.3 0.0 1.4 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase LRR_6 PF13516.1 KOO24940.1 - 0.04 13.9 11.6 7.2 7.0 0.0 6.1 6 0 0 6 6 6 0 Leucine Rich repeat LRR_1 PF00560.28 KOO24940.1 - 0.14 12.3 2.9 11 6.4 0.0 4.6 5 0 0 5 5 5 0 Leucine Rich Repeat Apolipoprotein PF01442.13 KOO24942.1 - 0.18 11.2 8.0 0.3 10.5 5.5 1.5 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Med3 PF11593.3 KOO24942.1 - 0.63 9.2 5.6 0.86 8.7 3.9 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Ribosomal_60s PF00428.14 KOO24942.1 - 3.6 8.0 14.3 0.094 13.1 4.9 2.0 2 1 0 2 2 2 0 60s Acidic ribosomal protein FKBP_C PF00254.23 KOO24943.1 - 2.7e-28 97.8 0.0 5e-28 96.9 0.0 1.4 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.13 KOO24943.1 - 0.085 12.9 0.9 0.12 12.3 0.6 1.2 1 0 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Asp PF00026.18 KOO24947.1 - 4.3e-26 91.9 0.3 1.7e-14 53.7 0.1 2.2 2 0 0 2 2 2 2 Eukaryotic aspartyl protease NYN_YacP PF05991.6 KOO24947.1 - 2.6e-07 30.5 0.0 5.2e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 YacP-like NYN domain TAXi_C PF14541.1 KOO24947.1 - 7.2e-05 22.3 0.0 0.0016 18.0 0.0 2.5 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal TAXi_N PF14543.1 KOO24947.1 - 0.00036 20.5 0.2 0.0009 19.2 0.1 1.7 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 KOO24947.1 - 0.0016 18.9 0.0 0.66 10.5 0.0 3.2 2 0 0 2 2 2 1 Aspartyl protease Asn_synthase PF00733.16 KOO24948.1 - 2e-14 53.7 0.0 3.1e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 KOO24948.1 - 1.8e-09 37.4 0.0 1.8e-08 34.1 0.0 2.3 2 1 0 2 2 2 1 Glutamine amidotransferase domain GATase_6 PF13522.1 KOO24948.1 - 2e-05 24.5 0.0 5.3e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain GDPD PF03009.12 KOO24951.1 - 2.7e-33 115.5 0.0 3e-21 76.1 0.0 4.4 3 2 0 3 3 3 3 Glycerophosphoryl diester phosphodiesterase family DUF1325 PF07039.6 KOO24951.1 - 0.0051 16.4 0.9 1.7 8.2 0.0 2.6 3 0 0 3 3 3 2 SGF29 tudor-like domain Peptidase_S9_N PF02897.10 KOO24951.1 - 0.1 11.1 2.3 2.1 6.8 0.2 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase, N-terminal beta-propeller domain Carb_anhydrase PF00194.16 KOO24951.1 - 0.29 10.0 0.7 1.3 7.9 0.1 2.0 2 0 0 2 2 2 0 Eukaryotic-type carbonic anhydrase Ribosomal_S8 PF00410.14 KOO24952.1 - 1e-24 86.8 0.0 1.3e-24 86.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 Ion_trans PF00520.26 KOO24953.1 - 4.4e-13 48.9 15.1 9.5e-13 47.8 10.4 1.5 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.24 KOO24953.1 - 7.3e-12 44.9 0.0 1.5e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.11 KOO24953.1 - 2.7e-11 42.9 7.2 2.7e-11 42.9 5.0 2.2 2 0 0 2 2 2 1 Ion channel Ion_trans_N PF08412.5 KOO24953.1 - 0.00012 21.3 0.0 0.00012 21.3 0.0 3.0 3 1 0 3 3 3 1 Ion transport protein N-terminal CBM_2 PF00553.14 KOO24955.1 - 0.077 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Cellulose binding domain PDZ PF00595.19 KOO24956.1 - 1.3e-07 31.6 2.5 0.053 13.7 0.1 3.5 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO24956.1 - 3.6e-05 23.5 1.1 0.48 10.3 0.1 3.7 3 0 0 3 3 3 2 PDZ domain Coiled-coil_56 PF09813.4 KOO24956.1 - 0.003 17.5 0.0 3.7 7.5 0.0 3.0 2 0 0 2 2 2 2 Coiled-coil domain-containing protein 56 FAA_hydrolase_N PF09298.6 KOO24956.1 - 0.3 11.0 3.8 33 4.5 0.6 3.7 3 1 0 3 3 3 0 Fumarylacetoacetase N-terminal DUF3446 PF11928.3 KOO24956.1 - 0.74 10.0 4.8 0.21 11.8 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3446) GATase_2 PF00310.16 KOO24962.1 - 7.9e-25 87.3 0.0 2.2e-20 72.6 0.0 2.2 1 1 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 KOO24962.1 - 1.3e-15 57.5 0.0 4.5e-15 55.7 0.0 1.9 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 KOO24962.1 - 1.3e-15 57.2 0.0 3.3e-15 55.9 0.0 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.22 KOO24962.1 - 3.6e-09 36.4 0.1 1.1e-08 34.8 0.1 1.7 2 0 0 2 2 2 1 Phosphoribosyl transferase domain GATase_4 PF13230.1 KOO24962.1 - 0.0018 17.0 0.0 0.0028 16.3 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II DUF1471 PF07338.8 KOO24962.1 - 0.14 11.7 0.2 1.5 8.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1471) Pkinase PF00069.20 KOO24963.1 - 2.1e-67 227.0 0.0 2.8e-67 226.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO24963.1 - 2.6e-31 108.6 1.1 3e-31 108.4 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO24963.1 - 0.00032 19.7 0.1 0.0041 16.1 0.0 2.3 1 1 1 2 2 2 1 Kinase-like APH PF01636.18 KOO24963.1 - 0.018 14.7 2.2 0.043 13.5 0.1 2.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family Flp_Fap PF04964.9 KOO24964.1 - 0.11 12.0 1.6 0.23 11.0 1.1 1.5 1 0 0 1 1 1 0 Flp/Fap pilin component DIOX_N PF14226.1 KOO24965.1 - 3.1e-23 82.5 0.0 5.9e-23 81.6 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 KOO24965.1 - 2.8e-18 66.0 0.0 5.4e-18 65.1 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Zw10 PF06248.8 KOO24966.1 - 7.1e-34 116.9 0.0 1.4e-24 86.2 0.0 2.1 2 0 0 2 2 2 2 Centromere/kinetochore Zw10 Tenui_N PF05733.6 KOO24966.1 - 0.95 8.7 3.2 1.6 7.9 0.2 2.1 2 0 0 2 2 2 0 Tenuivirus/Phlebovirus nucleocapsid protein SHIPPO-rpt PF07004.7 KOO24967.1 - 0.0049 17.6 5.2 0.047 14.5 2.3 2.9 2 1 0 2 2 2 1 Sperm-tail PG-rich repeat GrpE PF01025.14 KOO24968.1 - 4.3e-30 104.4 0.7 4e-27 94.7 0.0 2.0 2 0 0 2 2 2 2 GrpE DUF4199 PF13858.1 KOO24968.1 - 0.085 12.7 0.1 0.12 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Epimerase PF01370.16 KOO24969.1 - 8.2e-55 185.8 0.0 1e-54 185.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Epimerase_Csub PF13950.1 KOO24969.1 - 3.9e-27 93.9 0.1 7.3e-27 93.1 0.1 1.5 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit 3Beta_HSD PF01073.14 KOO24969.1 - 4.1e-19 68.3 0.0 1.7e-18 66.3 0.0 1.7 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 KOO24969.1 - 1.2e-16 60.4 0.0 3.1e-16 59.1 0.0 1.6 2 0 0 2 2 2 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 KOO24969.1 - 7.8e-15 54.5 0.1 4.1e-14 52.1 0.0 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.20 KOO24969.1 - 2.5e-13 50.2 0.4 4.6e-13 49.4 0.3 1.4 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.1 KOO24969.1 - 5.8e-11 42.7 0.0 1.2e-10 41.7 0.0 1.5 1 0 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 KOO24969.1 - 8.9e-11 41.1 0.0 3.5e-10 39.2 0.0 1.8 1 1 0 1 1 1 1 Male sterility protein KR PF08659.5 KOO24969.1 - 1.3e-08 34.7 0.4 3e-08 33.5 0.3 1.5 1 1 0 1 1 1 1 KR domain NmrA PF05368.8 KOO24969.1 - 4.4e-05 22.8 0.2 0.00083 18.6 0.2 2.1 2 0 0 2 2 2 1 NmrA-like family Saccharop_dh PF03435.13 KOO24969.1 - 0.011 14.7 0.7 0.016 14.2 0.5 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase Pkinase PF00069.20 KOO24970.1 - 4.7e-57 193.1 0.0 5.6e-57 192.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO24970.1 - 5e-26 91.3 0.0 7.2e-26 90.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO24970.1 - 9e-07 28.1 0.0 5.2e-06 25.6 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 KOO24970.1 - 0.0076 16.0 0.0 0.017 14.8 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 KOO24970.1 - 0.012 14.6 0.0 0.019 14.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 KOO24970.1 - 0.099 12.1 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Bromodomain PF00439.20 KOO24972.1 - 2.7e-15 56.0 0.0 5.5e-15 55.0 0.0 1.5 1 0 0 1 1 1 1 Bromodomain LysM PF01476.15 KOO24972.1 - 0.034 14.0 0.0 2 8.3 0.0 2.5 2 0 0 2 2 2 0 LysM domain EF-hand_1 PF00036.27 KOO24973.1 - 2.6e-36 120.1 17.4 1.9e-06 26.7 0.1 6.4 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.1 KOO24973.1 - 5.2e-35 119.3 9.2 3.7e-12 46.2 0.3 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO24973.1 - 1.2e-33 111.9 14.9 2.9e-05 23.5 0.0 6.5 6 0 0 6 6 6 6 EF-hand domain EF-hand_5 PF13202.1 KOO24973.1 - 3.4e-32 108.3 25.4 1.1e-07 30.8 0.3 6.5 6 0 0 6 6 6 6 EF hand EF-hand_8 PF13833.1 KOO24973.1 - 8e-25 86.2 22.2 6.8e-09 35.2 1.7 6.7 4 3 3 7 7 7 6 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO24973.1 - 5.9e-07 29.5 0.1 2.9 7.9 0.0 5.1 4 1 0 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO24973.1 - 0.0057 16.2 4.7 1.3 8.7 0.0 4.5 3 2 2 5 5 5 2 EF hand NADPH_Ox PF08414.5 KOO24973.1 - 0.1 12.6 0.2 2.5 8.2 0.0 2.9 3 0 0 3 3 3 0 Respiratory burst NADPH oxidase EF-hand_4 PF12763.2 KOO24973.1 - 5.2 6.8 6.0 32 4.3 0.5 3.5 2 2 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand Arf PF00025.16 KOO24974.1 - 8.7e-48 161.8 0.0 9.4e-48 161.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 KOO24974.1 - 1.3e-09 37.5 0.0 1.5e-09 37.3 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Miro PF08477.8 KOO24974.1 - 6.5e-09 36.3 0.0 8.4e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 KOO24974.1 - 1.6e-08 34.5 0.0 2e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.17 KOO24974.1 - 3.2e-07 29.8 0.0 3.6e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.7 KOO24974.1 - 9e-07 28.2 0.0 1.1e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Dynamin_N PF00350.18 KOO24974.1 - 4.6e-05 23.3 0.1 0.0034 17.2 0.0 2.2 1 1 0 2 2 2 1 Dynamin family GTP_EFTU PF00009.22 KOO24974.1 - 4.7e-05 22.8 0.0 0.0022 17.4 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain G-alpha PF00503.15 KOO24974.1 - 0.00016 20.5 0.0 0.0034 16.1 0.0 2.1 2 0 0 2 2 2 1 G-protein alpha subunit cobW PF02492.14 KOO24974.1 - 0.011 15.2 0.0 0.54 9.6 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.1 KOO24974.1 - 0.025 13.9 0.1 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.13 KOO24974.1 - 0.058 12.6 0.2 2.1 7.6 0.1 2.2 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_22 PF13401.1 KOO24974.1 - 0.11 12.6 0.0 0.72 9.9 0.0 2.1 1 1 0 1 1 1 0 AAA domain MobB PF03205.9 KOO24974.1 - 0.15 11.7 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_29 PF13555.1 KOO24974.1 - 0.21 11.1 0.5 0.66 9.5 0.0 2.0 3 0 0 3 3 3 0 P-loop containing region of AAA domain WD40 PF00400.27 KOO24975.1 - 1.2e-64 212.0 11.0 2.1e-10 40.0 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat PRP4 PF08799.6 KOO24975.1 - 1.2e-10 40.4 2.9 1.5e-10 40.1 0.9 2.1 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like eIF2A PF08662.6 KOO24975.1 - 2.9e-06 27.1 0.0 0.39 10.3 0.0 3.3 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 KOO24975.1 - 0.0021 16.2 4.5 2.6 6.0 0.0 3.8 2 2 1 4 4 4 3 Nucleoporin Nup120/160 HxlR PF01638.12 KOO24975.1 - 0.042 13.4 0.0 0.091 12.3 0.0 1.5 1 0 0 1 1 1 0 HxlR-like helix-turn-helix tRNA-synt_2 PF00152.15 KOO24976.1 - 4.5e-63 213.0 0.0 8.3e-63 212.1 0.0 1.4 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 KOO24976.1 - 5.8e-08 32.4 0.0 1.1e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Dpy-30 PF05186.8 KOO24976.1 - 0.019 14.4 0.0 0.042 13.3 0.0 1.7 1 0 0 1 1 1 0 Dpy-30 motif TMF_DNA_bd PF12329.3 KOO24976.1 - 0.17 11.7 7.0 0.41 10.4 4.8 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding CAGE1 PF15066.1 KOO24976.1 - 0.88 7.9 2.7 1.7 7.0 1.9 1.3 1 0 0 1 1 1 0 Cancer-associated gene protein 1 family Methyltransf_11 PF08241.7 KOO24977.1 - 1.4e-10 41.5 0.0 3.1e-10 40.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO24977.1 - 3.1e-06 26.9 0.0 4.1e-06 26.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO24977.1 - 1.1e-05 24.6 0.0 1.7e-05 24.0 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 KOO24977.1 - 2.4e-05 23.9 0.0 3.5e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.11 KOO24977.1 - 5.3e-05 21.7 0.0 6.8e-05 21.3 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_12 PF08242.7 KOO24977.1 - 5.8e-05 23.5 0.0 9.8e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 KOO24977.1 - 0.00029 20.5 0.0 0.00045 19.9 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_25 PF13649.1 KOO24977.1 - 0.043 14.1 0.0 0.1 12.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.2 KOO24977.1 - 0.13 12.8 0.0 0.27 11.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain EF-hand_6 PF13405.1 KOO24978.1 - 7.2e-31 103.2 20.2 3e-05 23.5 0.1 7.4 8 0 0 8 8 8 6 EF-hand domain EF-hand_7 PF13499.1 KOO24978.1 - 3.9e-28 97.3 15.7 2.5e-10 40.3 0.2 4.0 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.27 KOO24978.1 - 1.6e-27 92.6 21.2 6.4e-05 21.9 0.1 6.8 7 0 0 7 7 7 6 EF hand EF-hand_8 PF13833.1 KOO24978.1 - 7.7e-19 67.0 18.6 3.3e-08 33.0 0.0 6.1 4 2 2 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.1 KOO24978.1 - 1.1e-16 59.3 19.3 0.0014 17.9 0.1 6.3 6 0 0 6 6 6 5 EF hand SPARC_Ca_bdg PF10591.4 KOO24978.1 - 0.00032 20.7 1.6 4.4 7.3 0.0 3.9 4 0 0 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO24978.1 - 0.023 14.3 0.5 21 4.9 0.0 4.1 5 0 0 5 5 5 0 EF hand Armet PF10208.4 KOO24978.1 - 0.04 13.5 0.0 2.6 7.6 0.0 2.4 2 0 0 2 2 2 0 Degradation arginine-rich protein for mis-folding RBD PF02196.10 KOO24978.1 - 0.12 12.1 0.0 0.51 10.1 0.0 2.0 2 0 0 2 2 2 0 Raf-like Ras-binding domain EF-hand_4 PF12763.2 KOO24978.1 - 1.8 8.3 5.7 11 5.8 0.3 3.4 2 1 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand LmjF365940-deam PF14421.1 KOO24979.1 - 2e-51 174.1 0.4 1.9e-49 167.6 0.3 2.3 1 1 0 1 1 1 1 A distinct subfamily of CDD/CDA-like deaminases dCMP_cyt_deam_1 PF00383.17 KOO24979.1 - 0.00016 21.2 0.1 0.00094 18.8 0.1 2.0 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region Response_reg PF00072.19 KOO24980.1 - 0.00051 20.0 0.0 0.0012 18.7 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain TTL PF03133.10 KOO24981.1 - 3.5e-92 308.4 0.2 4.6e-92 308.0 0.2 1.0 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 KOO24981.1 - 2.7e-05 23.1 0.2 0.0093 14.7 0.0 2.9 2 1 0 2 2 2 2 YheC/D like ATP-grasp ATP-grasp_4 PF13535.1 KOO24981.1 - 6.8e-05 22.6 0.0 0.00013 21.7 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain tRNA-synt_2b PF00587.20 KOO24983.1 - 2.9e-44 150.6 0.1 4.7e-44 150.0 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 KOO24983.1 - 3.8e-20 71.6 0.1 7.6e-20 70.6 0.1 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.9 KOO24983.1 - 1.8e-10 40.5 0.0 4.7e-10 39.2 0.0 1.8 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.16 KOO24983.1 - 3.6e-10 39.5 0.0 1.6e-09 37.4 0.0 2.1 2 1 0 2 2 2 1 TGS domain HATPase_c PF02518.21 KOO24985.1 - 9.9e-27 92.8 0.0 2.6e-26 91.5 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 KOO24985.1 - 8.2e-18 64.4 0.0 1.3e-09 37.9 0.0 3.0 3 0 0 3 3 3 2 Response regulator receiver domain HisKA PF00512.20 KOO24985.1 - 6.3e-15 54.9 1.2 1.5e-14 53.6 0.0 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS PF00989.19 KOO24985.1 - 2.9e-11 43.1 0.4 0.0001 22.0 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.5 KOO24985.1 - 1.1e-07 31.7 0.1 0.00027 20.9 0.1 2.7 2 0 0 2 2 2 2 PAS fold Hpt PF01627.18 KOO24985.1 - 2.4e-06 27.4 1.2 8.4e-06 25.7 0.8 2.0 1 0 0 1 1 1 1 Hpt domain PAS_9 PF13426.1 KOO24985.1 - 1.8e-05 25.0 0.0 5.6e-05 23.4 0.0 1.9 1 1 0 1 1 1 1 PAS domain GAF PF01590.21 KOO24985.1 - 0.0002 21.5 0.3 0.00083 19.5 0.0 2.1 2 0 0 2 2 2 1 GAF domain Enkurin PF13864.1 KOO24986.1 - 0.024 14.8 0.8 0.032 14.4 0.6 1.3 1 0 0 1 1 1 0 Calmodulin-binding YlqD PF11068.3 KOO24986.1 - 0.028 14.4 0.3 0.033 14.2 0.2 1.1 1 0 0 1 1 1 0 YlqD protein DASH_Dam1 PF08653.5 KOO24986.1 - 0.064 13.0 0.3 8.7 6.1 0.1 2.1 2 0 0 2 2 2 0 DASH complex subunit Dam1 Speriolin_C PF15059.1 KOO24986.1 - 0.1 12.5 0.1 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Speriolin C-terminus MerR-DNA-bind PF09278.6 KOO24986.1 - 0.17 12.3 5.7 0.34 11.3 0.7 2.1 2 0 0 2 2 2 0 MerR, DNA binding Exostosin PF03016.10 KOO24987.1 - 4.6e-50 170.3 0.0 6e-50 169.9 0.0 1.1 1 0 0 1 1 1 1 Exostosin family IFT46_B_C PF12317.3 KOO24988.1 - 4.4e-29 101.3 0.3 5.8e-29 101.0 0.2 1.1 1 0 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal Cnd2 PF05786.9 KOO24988.1 - 1.5 7.2 5.1 2.2 6.6 3.5 1.3 1 0 0 1 1 1 0 Condensin complex subunit 2 ABC2_membrane_3 PF12698.2 KOO24989.1 - 4.4e-55 187.1 48.8 1.1e-29 103.5 14.7 2.8 3 0 0 3 3 3 2 ABC-2 family transporter protein ABC_tran PF00005.22 KOO24989.1 - 7.1e-51 172.1 0.0 1.8e-24 86.5 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 KOO24989.1 - 4.2e-18 66.3 0.0 2.1e-08 34.4 0.0 4.6 5 0 0 5 5 5 3 AAA domain SbcCD_C PF13558.1 KOO24989.1 - 5.3e-06 26.2 0.1 0.025 14.4 0.0 3.9 3 2 0 3 3 3 2 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.1 KOO24989.1 - 5.7e-05 22.5 3.0 0.028 13.9 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.14 KOO24989.1 - 0.00048 19.4 0.0 0.83 8.8 0.0 3.4 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain ABC2_membrane PF01061.19 KOO24989.1 - 0.0024 17.0 12.8 0.0024 17.0 8.9 3.1 3 0 0 3 3 2 1 ABC-2 type transporter AAA_23 PF13476.1 KOO24989.1 - 0.0025 18.1 0.9 1.6 8.9 0.1 2.4 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.16 KOO24989.1 - 0.027 13.6 0.5 1.4 8.0 0.1 3.2 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI ArgK PF03308.11 KOO24989.1 - 0.037 12.7 2.2 0.34 9.6 0.0 2.2 2 0 0 2 2 2 0 ArgK protein MukB PF04310.7 KOO24989.1 - 0.079 12.2 1.6 2.7 7.2 0.2 2.3 2 0 0 2 2 2 0 MukB N-terminal DUF4162 PF13732.1 KOO24989.1 - 0.11 13.0 0.0 46 4.6 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4162) AAA_33 PF13671.1 KOO24989.1 - 0.3 10.9 1.3 27 4.6 0.0 3.0 3 1 0 3 3 3 0 AAA domain SRP54 PF00448.17 KOO24989.1 - 0.4 10.0 4.4 4.5 6.6 0.9 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Zeta_toxin PF06414.7 KOO24989.1 - 0.47 9.5 0.5 4.5 6.3 0.0 2.5 3 0 0 3 3 3 0 Zeta toxin Galactosyl_T PF01762.16 KOO24990.1 - 6.7e-09 35.6 0.0 1.1e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Galactosyltransferase 2OG-FeII_Oxy_3 PF13640.1 KOO24991.1 - 4.3e-15 56.0 0.8 2.8e-06 27.7 0.0 2.6 2 2 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO24991.1 - 4.7e-14 51.7 0.2 2.7e-13 49.3 0.0 2.3 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO24991.1 - 2.7e-06 27.5 0.0 0.027 14.7 0.0 2.4 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.1 KOO24991.1 - 0.014 15.6 0.0 0.043 14.1 0.0 1.8 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase SHIPPO-rpt PF07004.7 KOO24992.1 - 6.4e-11 42.5 10.4 0.24 12.3 0.0 5.9 5 0 0 5 5 5 4 Sperm-tail PG-rich repeat Myosin_HC-like PF07058.6 KOO24992.1 - 0.034 13.2 0.7 0.034 13.2 0.5 2.2 1 1 1 2 2 2 0 Myosin II heavy chain-like ECR1_N PF14382.1 KOO24992.1 - 0.13 11.5 3.5 0.83 9.0 0.0 3.4 4 0 0 4 4 4 0 Exosome complex exonuclease RRP4 N-terminal region AIRC PF00731.15 KOO24993.1 - 3e-65 218.0 2.9 3e-65 218.0 2.0 2.5 2 0 0 2 2 2 1 AIR carboxylase ATP-grasp PF02222.17 KOO24993.1 - 6.2e-47 159.1 0.0 1.1e-46 158.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.1 KOO24993.1 - 3.4e-07 30.1 0.0 7.8e-07 28.9 0.0 1.6 1 1 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.12 KOO24993.1 - 0.017 14.4 0.0 0.029 13.6 0.0 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.8 KOO24993.1 - 0.032 13.6 0.0 0.07 12.4 0.0 1.5 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus Nramp PF01566.13 KOO24995.1 - 1.6e-97 326.5 9.3 2.2e-97 326.0 6.4 1.2 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein Filamin PF00630.14 KOO24996.1 - 2.7e-17 63.1 0.0 1.2e-09 38.6 0.0 4.2 3 1 0 3 3 3 3 Filamin/ABP280 repeat EF-hand_1 PF00036.27 KOO24996.1 - 3.8e-07 28.9 0.3 1.7e-05 23.8 0.2 2.5 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO24996.1 - 4.1e-06 26.8 0.0 1.1e-05 25.4 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO24996.1 - 1.6e-05 23.9 0.5 6.6e-05 22.0 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO24996.1 - 2e-05 24.0 0.1 8.7e-05 22.0 0.1 2.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.1 KOO24996.1 - 0.043 13.4 1.1 0.23 11.1 0.2 2.3 2 0 0 2 2 2 0 EF-hand domain pair TF_Zn_Ribbon PF08271.7 KOO24996.1 - 0.32 10.3 0.6 4.5 6.6 0.1 2.3 1 1 1 2 2 2 0 TFIIB zinc-binding Ion_trans PF00520.26 KOO24997.1 - 4.7e-168 554.8 42.6 5.3e-43 146.6 7.8 4.3 4 0 0 4 4 4 4 Ion transport protein Kelch_4 PF13418.1 KOO24997.1 - 2.9e-10 39.7 5.6 2.6e-05 23.8 0.5 3.2 3 0 0 3 3 3 2 Galactose oxidase, central domain PKD_channel PF08016.7 KOO24997.1 - 5.1e-10 38.3 45.0 2.1e-07 29.7 1.9 7.6 6 3 2 8 8 8 4 Polycystin cation channel Kelch_3 PF13415.1 KOO24997.1 - 4.3e-09 36.2 0.2 0.00074 19.6 0.1 3.6 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.10 KOO24997.1 - 5.3e-07 29.1 4.8 0.0032 17.1 0.3 3.0 3 0 0 3 3 3 2 Kelch motif IQ PF00612.22 KOO24997.1 - 0.00023 20.5 13.0 0.053 13.1 0.1 3.5 3 0 0 3 3 3 2 IQ calmodulin-binding motif Kelch_1 PF01344.20 KOO24997.1 - 0.00056 19.3 0.1 0.5 9.9 0.0 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.1 KOO24997.1 - 0.0071 16.4 0.5 0.028 14.6 0.1 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.1 KOO24997.1 - 0.024 14.6 0.0 0.53 10.2 0.0 2.6 2 0 0 2 2 2 0 Kelch motif GspH PF12019.3 KOO24997.1 - 0.042 13.9 0.1 0.14 12.2 0.0 1.9 1 0 0 1 1 1 0 Type II transport protein GspH OppC_N PF12911.2 KOO24997.1 - 2.7 7.4 10.0 3.6 7.0 0.3 4.0 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C DnaJ PF00226.26 KOO24998.1 - 4.6e-26 90.3 3.8 7e-26 89.7 2.6 1.3 1 0 0 1 1 1 1 DnaJ domain YajC PF02699.10 KOO24998.1 - 0.012 15.2 2.6 1.3 8.7 0.0 2.5 2 0 0 2 2 2 0 Preprotein translocase subunit WD40 PF00400.27 KOO24999.1 - 6.6e-05 22.6 4.7 0.0011 18.7 0.1 4.5 4 1 0 4 4 4 1 WD domain, G-beta repeat PIP5K PF01504.13 KOO25000.1 - 4.5e-57 193.0 0.0 1.5e-35 122.5 0.1 2.2 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase EF-hand_1 PF00036.27 KOO25000.1 - 8e-22 74.8 4.4 5.8e-06 25.2 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO25000.1 - 1.6e-21 76.1 4.8 7.2e-10 38.8 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO25000.1 - 7.2e-18 62.8 7.1 0.00043 19.9 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 KOO25000.1 - 4.3e-17 61.4 8.0 3.2e-05 23.4 0.0 4.5 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO25000.1 - 3.8e-15 54.4 9.2 0.00014 21.0 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.1 KOO25000.1 - 0.018 14.9 0.5 17 5.3 0.0 4.3 3 1 2 5 5 5 0 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO25000.1 - 0.11 12.5 0.0 8 6.5 0.0 2.8 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region FKBP_C PF00254.23 KOO25001.1 - 2.8e-15 56.0 0.0 6.2e-15 54.9 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_11 PF13414.1 KOO25001.1 - 6.6e-14 51.3 5.3 1.7e-08 34.0 1.1 2.5 1 1 1 2 2 2 2 TPR repeat TPR_12 PF13424.1 KOO25001.1 - 2.7e-08 33.6 2.1 8.3e-08 32.0 1.4 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO25001.1 - 3.1e-07 29.7 1.0 5.2e-05 22.6 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO25001.1 - 1.7e-05 25.3 0.8 1.7e-05 25.3 0.6 3.1 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO25001.1 - 5.6e-05 22.6 0.5 0.00078 19.0 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO25001.1 - 0.00016 21.2 11.4 0.00022 20.8 0.1 3.5 4 0 0 4 4 3 2 Tetratricopeptide repeat Apc3 PF12895.2 KOO25001.1 - 0.00046 20.2 0.4 0.0008 19.4 0.3 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 KOO25001.1 - 0.00093 19.4 1.8 0.0017 18.6 0.4 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO25001.1 - 0.04 14.1 0.3 0.62 10.4 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TOM20_plant PF06552.7 KOO25001.1 - 0.084 12.4 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_6 PF13174.1 KOO25001.1 - 0.12 12.9 2.0 0.34 11.4 0.3 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO25001.1 - 0.21 12.2 10.0 0.25 12.0 0.3 3.6 3 1 1 4 4 2 0 Tetratricopeptide repeat Med29 PF11568.3 KOO25002.1 - 0.13 12.3 0.1 0.89 9.5 0.2 2.0 2 0 0 2 2 2 0 Mediator complex subunit 29 PIG-Y PF15159.1 KOO25002.1 - 0.21 11.8 3.7 0.74 10.0 1.3 2.5 1 1 1 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y DUF1785 PF08699.5 KOO25003.1 - 0.071 12.4 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1785) PP28 PF10252.4 KOO25003.1 - 0.11 12.4 0.3 0.11 12.4 0.2 2.1 3 0 0 3 3 3 0 Casein kinase substrate phosphoprotein PP28 Ion_trans PF00520.26 KOO25004.1 - 1.7e-25 89.4 6.7 2.2e-25 89.1 4.6 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO25004.1 - 4.4e-16 58.3 3.1 1.4e-15 56.7 2.2 1.9 1 0 0 1 1 1 1 Ion channel DUF1077 PF06417.7 KOO25004.1 - 0.04 13.2 1.0 1.2 8.4 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1077) DUF202 PF02656.10 KOO25004.1 - 0.2 11.8 2.2 5.5 7.2 0.2 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF202) Gly_transf_sug PF04488.10 KOO25005.1 - 5.5e-13 49.1 0.0 8.1e-13 48.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 KOO25005.1 - 0.17 10.3 0.4 0.3 9.5 0.0 1.5 2 0 0 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain ubiquitin PF00240.18 KOO25006.1 - 2.8e-17 61.8 0.0 4.1e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family DNA_RNApol_7kD PF03604.8 KOO25006.1 - 1.6e-16 59.4 5.0 2.4e-16 58.8 3.5 1.3 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit Rad60-SLD PF11976.3 KOO25006.1 - 8.1e-10 38.2 0.0 1.6e-09 37.3 0.0 1.5 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 KOO25006.1 - 0.0017 18.4 0.0 0.0018 18.4 0.0 1.1 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.1 KOO25006.1 - 0.0065 16.3 0.0 0.01 15.7 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DZR PF12773.2 KOO25006.1 - 0.035 13.9 0.3 0.058 13.2 0.2 1.3 1 0 0 1 1 1 0 Double zinc ribbon OrfB_Zn_ribbon PF07282.6 KOO25006.1 - 0.059 13.0 0.1 0.095 12.3 0.0 1.3 1 0 0 1 1 1 0 Putative transposase DNA-binding domain GABP-alpha PF11620.3 KOO25006.1 - 0.075 13.0 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 GA-binding protein alpha chain A2L_zn_ribbon PF08792.5 KOO25006.1 - 0.087 12.3 1.0 0.16 11.4 0.7 1.4 1 0 0 1 1 1 0 A2L zinc ribbon domain YukD PF08817.5 KOO25006.1 - 0.11 13.0 0.1 0.17 12.4 0.1 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD ATP-synt_B PF00430.13 KOO25007.1 - 0.019 14.7 13.6 0.021 14.6 9.4 1.0 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) V-ATPase_G PF03179.10 KOO25007.1 - 0.042 14.1 6.9 0.042 14.1 4.8 1.8 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit TPR_MLP1_2 PF07926.7 KOO25007.1 - 0.057 13.1 3.1 0.063 13.0 2.1 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein COG2 PF06148.6 KOO25007.1 - 0.094 12.5 1.1 0.099 12.5 0.8 1.0 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 CSS-motif PF12792.2 KOO25007.1 - 0.25 10.6 2.3 0.27 10.5 1.6 1.2 1 0 0 1 1 1 0 CSS motif domain associated with EAL Plasmid_RAQPRD PF09686.5 KOO25007.1 - 0.33 11.0 7.5 0.53 10.4 5.2 1.5 1 1 0 1 1 1 0 Plasmid protein of unknown function (Plasmid_RAQPRD) WEMBL PF05701.6 KOO25007.1 - 0.37 9.2 11.5 0.39 9.1 8.0 1.0 1 0 0 1 1 1 0 Weak chloroplast movement under blue light DivIVA PF05103.8 KOO25007.1 - 0.51 10.3 6.3 0.61 10.1 4.3 1.1 1 0 0 1 1 1 0 DivIVA protein DUF3391 PF11871.3 KOO25007.1 - 0.57 10.4 3.4 0.65 10.2 2.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) DUF3359 PF11839.3 KOO25007.1 - 0.77 10.1 13.6 0.97 9.8 9.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3359) DUF4337 PF14235.1 KOO25007.1 - 2.4 7.9 6.5 2.9 7.7 4.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) KIAA1430 PF13879.1 KOO25008.1 - 3.2e-08 33.8 11.2 0.0019 18.5 0.4 3.3 2 1 1 3 3 3 3 KIAA1430 homologue RcbX PF02341.10 KOO25008.1 - 0.002 18.2 2.4 0.022 14.8 1.0 2.3 2 0 0 2 2 2 1 RbcX protein NYD-SP28_assoc PF14775.1 KOO25008.1 - 0.16 11.6 10.2 0.6 9.8 0.5 3.4 3 0 0 3 3 3 0 Sperm tail C-terminal domain FlaC_arch PF05377.6 KOO25008.1 - 1.2 9.1 4.2 16 5.5 0.3 2.7 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DivIC PF04977.10 KOO25008.1 - 8 6.0 25.3 1.1 8.8 2.3 4.2 2 1 2 4 4 4 0 Septum formation initiator Mod_r PF07200.8 KOO25008.1 - 8.4 6.2 15.8 3.7 7.4 2.7 3.5 1 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein FF PF01846.14 KOO25009.1 - 3.4e-37 126.1 2.6 3.9e-11 42.7 0.1 4.6 4 0 0 4 4 4 4 FF domain WW PF00397.21 KOO25009.1 - 1.5e-18 66.3 14.4 2e-09 37.1 3.1 3.2 3 0 0 3 3 3 2 WW domain SpoVAE PF14097.1 KOO25009.1 - 0.018 14.4 0.0 0.03 13.7 0.0 1.3 1 0 0 1 1 1 0 Stage V sporulation protein AE1 Zip PF02535.17 KOO25009.1 - 1.2 8.0 4.2 1.9 7.4 2.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter SelP_N PF04592.9 KOO25009.1 - 4.2 6.6 8.8 7.5 5.8 6.1 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Glyco_hydro_101 PF12905.2 KOO25009.1 - 5.1 5.6 8.6 0.76 8.3 0.3 2.4 2 1 1 3 3 3 0 Endo-alpha-N-acetylgalactosaminidase Exostosin PF03016.10 KOO25010.1 - 0.047 12.7 0.0 0.053 12.5 0.0 1.1 1 0 0 1 1 1 0 Exostosin family Spc97_Spc98 PF04130.8 KOO25011.1 - 2.7e-13 49.1 0.0 2.8e-13 49.0 0.0 1.0 1 0 0 1 1 1 1 Spc97 / Spc98 family DUF389 PF04087.9 KOO25011.1 - 0.0042 17.0 0.1 0.008 16.1 0.1 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF389) FTO_CTD PF12934.2 KOO25011.1 - 0.14 11.7 0.0 0.15 11.5 0.0 1.1 1 0 0 1 1 1 0 FTO C-terminal domain Acetyltransf_1 PF00583.19 KOO25012.1 - 6e-05 22.9 0.0 0.00015 21.7 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 KOO25012.1 - 0.037 14.1 0.0 0.096 12.8 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 KOO25012.1 - 0.077 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Spc97_Spc98 PF04130.8 KOO25013.1 - 7e-39 133.5 0.4 8.9e-39 133.2 0.3 1.1 1 0 0 1 1 1 1 Spc97 / Spc98 family Fib_alpha PF08702.5 KOO25014.1 - 0.11 12.6 1.4 20 5.3 1.4 2.4 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family GPW_gp25 PF04965.9 KOO25014.1 - 0.12 11.9 8.5 2.1 7.9 0.1 4.3 4 0 0 4 4 4 0 Gene 25-like lysozyme Atg14 PF10186.4 KOO25014.1 - 0.27 10.1 0.1 0.27 10.1 0.0 3.1 2 1 1 3 3 3 0 UV radiation resistance protein and autophagy-related subunit 14 AAA_13 PF13166.1 KOO25014.1 - 3.3 6.0 16.1 4.4 5.6 7.0 2.1 2 0 0 2 2 2 0 AAA domain Mnd1 PF03962.10 KOO25014.1 - 8.6 5.9 23.6 8.8 5.9 0.0 3.4 2 1 2 4 4 4 0 Mnd1 family MIP PF00230.15 KOO25015.1 - 5.1e-25 88.2 15.6 5.1e-25 88.2 10.8 2.4 1 1 1 2 2 2 1 Major intrinsic protein Zip PF02535.17 KOO25016.1 - 8.9e-14 51.2 14.2 1.8e-11 43.6 0.6 2.2 2 0 0 2 2 2 2 ZIP Zinc transporter DUF1700 PF08006.6 KOO25016.1 - 0.035 13.4 0.3 0.035 13.4 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) Tir_receptor_C PF07489.6 KOO25016.1 - 4.8 6.8 5.6 19 4.8 0.0 2.6 3 0 0 3 3 3 0 Translocated intimin receptor (Tir) C-terminus Ferric_reduct PF01794.14 KOO25017.1 - 9.1e-07 29.0 12.8 2.6e-06 27.5 8.9 1.8 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 KOO25017.1 - 0.0014 18.4 0.0 0.0028 17.4 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain Lebercilin PF15619.1 KOO25017.1 - 0.075 12.4 1.2 3.8 6.9 0.4 2.1 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF4336 PF14234.1 KOO25018.1 - 9.5e-91 303.9 0.0 1.3e-90 303.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4336) cNMP_binding PF00027.24 KOO25018.1 - 1.1e-10 41.1 0.0 0.00045 19.9 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain ADH_zinc_N PF00107.21 KOO25019.1 - 1.3e-20 73.3 0.2 2e-20 72.6 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TrkA_N PF02254.13 KOO25019.1 - 0.0072 16.3 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain 2-Hacid_dh_C PF02826.14 KOO25019.1 - 0.0077 15.4 0.0 0.014 14.5 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 KOO25019.1 - 0.0091 15.3 0.4 0.015 14.7 0.3 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.16 KOO25019.1 - 0.0093 15.5 0.2 0.019 14.5 0.1 1.5 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FIST PF08495.5 KOO25019.1 - 0.18 10.9 2.1 0.72 8.9 0.0 2.4 2 2 0 2 2 2 0 FIST N domain DUF973 PF06157.6 KOO25020.1 - 0.0067 15.4 0.1 0.011 14.6 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF973) CD20 PF04103.10 KOO25020.1 - 0.38 10.6 11.3 2.6 7.9 7.9 2.2 1 1 0 1 1 1 0 CD20-like family Claudin_2 PF13903.1 KOO25020.1 - 0.89 9.2 6.5 0.5 10.0 2.3 1.9 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction PAS_9 PF13426.1 KOO25021.1 - 1.6e-06 28.4 0.0 2.7e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS PF00989.19 KOO25021.1 - 3e-05 23.7 0.0 4.9e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.6 KOO25021.1 - 0.0066 16.5 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.5 KOO25021.1 - 0.014 15.4 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 PAS fold EF-hand_7 PF13499.1 KOO25022.1 - 2.8e-14 53.0 0.9 5.1e-14 52.1 0.6 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO25022.1 - 4.1e-14 50.7 8.3 3.5e-07 29.0 0.2 2.7 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO25022.1 - 4.2e-13 47.9 1.9 1.4e-06 27.6 0.2 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO25022.1 - 4.7e-12 44.6 1.0 2.4e-05 23.4 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO25022.1 - 5.3e-10 38.7 0.2 5.3e-10 38.7 0.2 2.2 4 0 0 4 4 4 1 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO25022.1 - 0.00058 19.8 0.1 0.001 19.0 0.0 1.4 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO25022.1 - 0.0025 17.4 0.2 0.006 16.2 0.2 1.7 1 0 0 1 1 1 1 EF hand EF-hand_4 PF12763.2 KOO25022.1 - 0.026 14.2 0.5 1.2 8.9 0.1 2.2 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand PMBR PF09373.5 KOO25022.1 - 0.045 13.7 0.0 1.3 9.0 0.0 2.9 3 0 0 3 3 3 0 Pseudomurein-binding repeat HTH_19 PF12844.2 KOO25022.1 - 0.046 13.7 0.1 0.1 12.6 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain DUF4157 PF13699.1 KOO25022.1 - 0.051 13.7 0.2 0.11 12.6 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4157) TerB PF05099.8 KOO25022.1 - 0.06 13.0 0.1 0.099 12.3 0.1 1.6 1 1 0 1 1 1 0 Tellurite resistance protein TerB Sigma70_r1_1 PF03979.9 KOO25022.1 - 0.08 12.8 0.1 8 6.4 0.0 2.4 2 0 0 2 2 2 0 Sigma-70 factor, region 1.1 Actin PF00022.14 KOO25023.1 - 2e-52 177.9 0.0 1.7e-48 165.0 0.0 2.1 1 1 1 2 2 2 2 Actin DUF2505 PF10698.4 KOO25024.1 - 7.9e-05 22.2 0.3 0.00035 20.0 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2505) HAUS6_N PF14661.1 KOO25024.1 - 0.54 9.5 19.4 0.13 11.5 6.3 2.3 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Pkinase PF00069.20 KOO25025.1 - 1.2e-12 47.5 0.0 2.6e-12 46.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25025.1 - 0.0012 17.9 0.0 0.0035 16.4 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Reo_sigmaC PF04582.7 KOO25025.1 - 0.24 10.5 1.4 0.34 10.0 1.0 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein LRR_4 PF12799.2 KOO25026.1 - 3.3e-15 55.3 0.7 2.5e-09 36.5 0.1 2.1 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO25026.1 - 7.2e-14 51.2 0.9 7e-08 32.1 0.1 1.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.28 KOO25026.1 - 2.7e-07 29.6 0.0 0.21 11.7 0.0 3.1 3 0 0 3 3 3 3 Leucine Rich Repeat LRR_7 PF13504.1 KOO25026.1 - 6.7e-07 28.4 1.4 0.26 11.6 0.1 3.3 3 0 0 3 3 3 3 Leucine rich repeat LRR_6 PF13516.1 KOO25026.1 - 0.00071 19.3 0.9 9.5 6.6 0.0 3.2 3 0 0 3 3 3 2 Leucine Rich repeat DUF3782 PF12644.2 KOO25026.1 - 0.085 12.6 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3782) Sld5 PF05916.6 KOO25027.1 - 0.012 15.8 1.7 0.021 15.1 1.2 1.4 1 0 0 1 1 1 0 GINS complex protein P4Ha_N PF08336.6 KOO25027.1 - 0.066 13.0 2.3 0.22 11.3 1.5 1.9 1 1 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region BAR_2 PF10455.4 KOO25027.1 - 0.077 11.8 0.8 0.1 11.4 0.5 1.1 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking Methyltransf_28 PF02636.12 KOO25028.1 - 1.7e-14 53.8 0.0 3.6e-14 52.7 0.0 1.4 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase RVT_2 PF07727.9 KOO25028.1 - 1.9e-09 36.8 0.0 4.2e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Methyltransf_18 PF12847.2 KOO25028.1 - 0.0027 18.2 0.0 0.0059 17.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Filamin PF00630.14 KOO25030.1 - 1.5e-48 163.4 0.0 1.4e-16 60.8 0.0 6.4 6 0 0 6 6 6 6 Filamin/ABP280 repeat Big_1 PF02369.11 KOO25030.1 - 0.0039 17.0 0.0 0.16 11.8 0.0 3.4 3 0 0 3 3 3 1 Bacterial Ig-like domain (group 1) Neurexophilin PF06312.7 KOO25030.1 - 0.0058 15.8 0.1 0.21 10.8 0.0 2.6 3 0 0 3 3 3 1 Neurexophilin SH3_3 PF08239.6 KOO25030.1 - 0.034 14.3 0.0 0.074 13.2 0.0 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain Hint PF01079.15 KOO25031.1 - 1.7e-15 56.8 0.1 2e-15 56.5 0.1 1.0 1 0 0 1 1 1 1 Hint module Laminin_G_3 PF13385.1 KOO25033.1 - 2.6e-08 34.2 0.9 9.5e-08 32.4 0.7 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Rhodanese PF00581.15 KOO25034.1 - 1.1e-07 32.1 0.0 4.3e-07 30.2 0.0 1.9 2 0 0 2 2 2 1 Rhodanese-like domain Thioredoxin PF00085.15 KOO25035.1 - 5.8e-15 54.8 0.0 3.6e-11 42.6 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.1 KOO25035.1 - 8.7e-09 35.4 0.0 0.0089 15.8 0.0 3.7 4 0 0 4 4 4 3 Thioredoxin-like domain Thioredoxin_2 PF13098.1 KOO25035.1 - 0.0093 16.1 0.0 4.6 7.4 0.0 3.3 2 1 0 2 2 2 1 Thioredoxin-like domain TFCD_C PF12612.3 KOO25035.1 - 0.014 14.7 0.0 0.026 13.9 0.0 1.4 1 0 0 1 1 1 0 Tubulin folding cofactor D C terminal HALZ PF02183.13 KOO25035.1 - 0.04 13.6 4.4 0.12 12.0 2.3 2.1 2 0 0 2 2 2 0 Homeobox associated leucine zipper Thioredoxin_7 PF13899.1 KOO25035.1 - 0.068 13.2 0.0 0.34 10.9 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin-like DUF972 PF06156.8 KOO25035.1 - 0.089 13.1 0.7 0.15 12.3 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) Pkinase PF00069.20 KOO25036.1 - 8.1e-70 234.9 0.0 9.3e-70 234.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25036.1 - 2.2e-44 151.4 0.0 2.8e-44 151.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO25036.1 - 8.9e-09 34.7 0.0 2.3e-07 30.0 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 KOO25036.1 - 9e-05 22.3 5.3 0.078 12.6 0.0 2.6 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.9 KOO25036.1 - 0.00083 18.4 0.1 0.0013 17.8 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 KOO25036.1 - 0.019 14.3 0.1 0.046 13.0 0.0 1.6 2 0 0 2 2 2 0 RIO1 family Seadorna_VP7 PF07387.6 KOO25036.1 - 0.095 11.5 0.0 0.17 10.6 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Ribosomal_L32p PF01783.18 KOO25037.1 - 0.00073 19.6 2.9 0.0011 19.1 2.0 1.2 1 0 0 1 1 1 1 Ribosomal L32p protein family STIL_N PF15253.1 KOO25038.1 - 3.6e-22 78.6 0.0 1.2e-21 76.9 0.0 1.7 2 0 0 2 2 2 1 SCL-interrupting locus protein N-terminus UPRTase PF14681.1 KOO25039.1 - 8.1e-54 181.9 0.1 9.7e-54 181.7 0.1 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 KOO25039.1 - 0.00056 19.6 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DivIC PF04977.10 KOO25040.1 - 0.017 14.5 0.2 0.1 12.1 0.0 2.3 2 0 0 2 2 2 0 Septum formation initiator zf-C4H2 PF10146.4 KOO25040.1 - 0.051 13.5 1.1 0.14 12.1 0.8 1.9 1 1 0 1 1 1 0 Zinc finger-containing protein ATG16 PF08614.6 KOO25040.1 - 0.072 12.9 10.6 0.26 11.0 4.2 2.3 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) COG5 PF10392.4 KOO25040.1 - 0.14 12.1 2.9 4.5 7.2 0.0 2.7 2 1 1 3 3 3 0 Golgi transport complex subunit 5 Apolipoprotein PF01442.13 KOO25040.1 - 0.19 11.1 19.3 0.88 9.0 7.7 3.1 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain DUF972 PF06156.8 KOO25040.1 - 3.3 8.0 5.6 4.2 7.7 0.0 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF972) DUF4200 PF13863.1 KOO25040.1 - 3.9 7.4 13.3 5.1 7.0 1.9 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) OHCU_decarbox PF09349.5 KOO25041.1 - 7.4e-49 166.0 2.0 9.3e-49 165.7 1.4 1.1 1 0 0 1 1 1 1 OHCU decarboxylase Transthyretin PF00576.16 KOO25041.1 - 1.7e-33 114.8 0.0 4.1e-33 113.6 0.0 1.6 2 0 0 2 2 2 1 HIUase/Transthyretin family RFamide_26RFa PF11109.3 KOO25041.1 - 0.032 14.1 3.0 5.3 6.9 0.0 2.6 2 1 0 2 2 2 0 Orexigenic neuropeptide Qrfp/P518 ABC_membrane PF00664.18 KOO25043.1 - 9.1e-40 136.8 6.1 2e-39 135.6 4.3 1.6 1 0 0 1 1 1 1 ABC transporter transmembrane region ZZ PF00569.12 KOO25043.1 - 0.0027 17.2 6.5 0.0027 17.2 4.5 1.8 2 0 0 2 2 2 1 Zinc finger, ZZ type zf-B_box PF00643.19 KOO25043.1 - 3 7.8 7.5 7.2 6.5 5.2 1.6 1 0 0 1 1 1 0 B-box zinc finger Myb_DNA-binding PF00249.26 KOO25044.1 - 2.4e-29 101.1 2.0 1.2e-14 54.0 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO25044.1 - 3.7e-23 81.3 1.4 2.1e-15 56.5 0.1 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain Rap1_C PF11626.3 KOO25044.1 - 0.0043 16.9 1.2 2.2 8.2 0.9 3.0 2 1 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Pilt PF15453.1 KOO25044.1 - 0.11 12.1 6.1 0.18 11.4 4.2 1.3 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions CDC27 PF09507.5 KOO25044.1 - 6.7 5.8 12.2 9.6 5.3 8.5 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Peptidase_M14 PF00246.19 KOO25045.1 - 4.6e-42 144.5 0.0 9.1e-42 143.5 0.0 1.4 1 0 0 1 1 1 1 Zinc carboxypeptidase SUI1 PF01253.17 KOO25046.1 - 5.7e-10 38.8 0.0 1.4e-09 37.6 0.0 1.7 1 0 0 1 1 1 1 Translation initiation factor SUI1 PUA PF01472.15 KOO25046.1 - 0.0058 16.3 0.2 0.013 15.2 0.2 1.6 1 0 0 1 1 1 1 PUA domain Kin17_mid PF10357.4 KOO25046.1 - 0.0077 15.8 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein Thioredoxin PF00085.15 KOO25047.1 - 3.9e-21 74.6 0.0 4.9e-21 74.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 KOO25047.1 - 5.6e-05 23.1 0.0 0.00011 22.2 0.0 1.6 2 0 0 2 2 2 1 Thioredoxin-like Redoxin PF08534.5 KOO25047.1 - 0.0017 17.9 0.0 0.0034 16.9 0.0 1.4 1 1 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 KOO25047.1 - 0.0028 17.3 0.0 0.0034 17.0 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_9 PF14595.1 KOO25047.1 - 0.0036 16.8 0.0 0.0044 16.5 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 KOO25047.1 - 0.004 17.3 0.0 0.016 15.4 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Glutaredoxin PF00462.19 KOO25047.1 - 0.15 12.0 0.1 1.5 8.8 0.0 2.2 1 1 1 2 2 2 0 Glutaredoxin COPI_assoc PF08507.5 KOO25048.1 - 1.9e-08 34.0 6.9 2.3e-08 33.7 4.8 1.1 1 0 0 1 1 1 1 COPI associated protein Cg6151-P PF10233.4 KOO25048.1 - 0.02 14.8 4.2 0.04 13.8 2.8 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein CG6151-P Myosin_head PF00063.16 KOO25051.1 - 1.9e-180 601.3 0.1 2.6e-180 600.8 0.1 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_N PF02736.14 KOO25051.1 - 0.0051 16.4 0.3 0.011 15.3 0.2 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_19 PF13245.1 KOO25051.1 - 0.0069 16.1 0.0 0.021 14.5 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 KOO25051.1 - 0.41 10.6 0.0 0.41 10.6 0.0 2.8 2 0 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.22 KOO25052.1 - 1.5e-18 67.3 0.0 1.9e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 KOO25052.1 - 6.4e-07 29.6 0.0 8.9e-06 25.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.14 KOO25052.1 - 1.6e-06 27.5 0.1 0.036 13.3 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 KOO25052.1 - 0.00036 19.9 0.0 0.00082 18.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_17 PF13207.1 KOO25052.1 - 0.0016 19.2 0.0 0.003 18.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 KOO25052.1 - 0.0037 16.7 0.1 0.0094 15.3 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_13 PF13166.1 KOO25052.1 - 0.0089 14.5 0.0 0.011 14.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 KOO25052.1 - 0.0095 15.8 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KOO25052.1 - 0.024 14.7 0.9 0.65 10.1 0.1 2.4 1 1 1 2 2 2 0 AAA domain AAA_23 PF13476.1 KOO25052.1 - 0.03 14.6 0.0 0.052 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 KOO25052.1 - 0.034 13.3 0.0 0.061 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_18 PF13238.1 KOO25052.1 - 0.048 13.9 0.0 0.26 11.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 KOO25052.1 - 0.077 12.4 0.1 0.18 11.2 0.0 1.5 2 0 0 2 2 2 0 AAA-like domain MutS_V PF00488.16 KOO25052.1 - 0.14 11.5 0.0 5.2 6.4 0.0 2.1 2 0 0 2 2 2 0 MutS domain V MORN PF02493.15 KOO25053.1 - 1.4e-42 140.8 48.1 1e-05 24.9 0.1 9.0 9 0 0 9 9 9 8 MORN repeat Flagellin_N PF00669.15 KOO25053.1 - 0.099 12.4 0.1 0.17 11.7 0.1 1.3 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region Thiolase_N PF00108.18 KOO25054.1 - 1.9e-78 263.0 2.1 1.9e-78 263.0 1.4 1.5 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 KOO25054.1 - 1.8e-47 159.8 1.8 1.8e-47 159.8 1.2 2.0 2 0 0 2 2 2 1 Thiolase, C-terminal domain Dodecin PF07311.7 KOO25054.1 - 0.052 13.5 0.0 0.21 11.6 0.0 2.0 2 0 0 2 2 2 0 Dodecin ACP_syn_III_C PF08541.5 KOO25054.1 - 0.054 13.5 0.3 0.19 11.7 0.2 2.0 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal LRR_8 PF13855.1 KOO25055.1 - 1.3e-15 56.8 12.9 9.2e-11 41.3 1.9 2.6 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.2 KOO25055.1 - 4.1e-14 51.8 5.0 5.8e-10 38.5 0.4 2.9 3 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.1 KOO25055.1 - 1e-09 38.1 0.0 1.5e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_7 PF13504.1 KOO25055.1 - 3.6e-07 29.3 3.1 0.046 13.9 0.0 4.8 4 1 0 4 4 4 2 Leucine rich repeat LRR_1 PF00560.28 KOO25055.1 - 1.3e-06 27.5 6.1 0.037 14.0 0.1 4.2 4 0 0 4 4 4 3 Leucine Rich Repeat LRR_6 PF13516.1 KOO25055.1 - 1.5e-06 27.6 3.8 0.23 11.6 0.1 4.7 3 1 2 5 5 5 3 Leucine Rich repeat NnrU PF07298.6 KOO25056.1 - 1.1e-06 28.2 2.1 1.5e-06 27.6 1.5 1.3 1 0 0 1 1 1 1 NnrU protein cNMP_binding PF00027.24 KOO25057.1 - 1.8e-13 50.1 0.8 0.0018 18.0 0.0 3.9 3 1 0 3 3 3 3 Cyclic nucleotide-binding domain Mito_carr PF00153.22 KOO25058.1 - 3.3e-06 26.7 0.0 5.4e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial carrier protein YtxH PF12732.2 KOO25058.1 - 0.2 12.0 0.9 0.37 11.1 0.7 1.5 1 0 0 1 1 1 0 YtxH-like protein Mnd1 PF03962.10 KOO25059.1 - 4.6e-28 98.1 1.5 5.1e-28 98.0 1.1 1.1 1 0 0 1 1 1 1 Mnd1 family DUF3365 PF11845.3 KOO25059.1 - 0.023 14.5 1.2 0.033 14.0 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3365) HTH_27 PF13463.1 KOO25059.1 - 0.061 13.6 0.1 0.22 11.8 0.0 1.9 2 0 0 2 2 2 0 Winged helix DNA-binding domain Atg14 PF10186.4 KOO25059.1 - 0.1 11.5 3.6 0.1 11.4 2.5 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 RHH_1 PF01402.16 KOO25059.1 - 0.35 10.8 5.0 0.79 9.7 0.1 3.3 3 1 0 3 3 3 0 Ribbon-helix-helix protein, copG family DUF972 PF06156.8 KOO25059.1 - 1 9.7 4.7 1.9 8.8 3.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) ATP-synt PF00231.14 KOO25060.1 - 4.6e-98 328.1 4.1 5.3e-98 327.9 2.8 1.0 1 0 0 1 1 1 1 ATP synthase Toxin_39 PF15500.1 KOO25060.1 - 0.28 11.3 4.3 4.2 7.5 0.8 2.6 2 0 0 2 2 2 0 Putative RNase-like toxin Rad1 PF02144.11 KOO25061.1 - 1.2e-27 96.3 0.0 1.6e-27 95.9 0.0 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 DnaJ PF00226.26 KOO25062.1 - 1.6e-21 75.8 0.0 3.2e-21 74.8 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain SBDS_C PF09377.5 KOO25062.1 - 0.0076 15.9 0.1 0.025 14.2 0.0 1.8 2 0 0 2 2 2 1 SBDS protein C-terminal domain DUF4398 PF14346.1 KOO25062.1 - 0.03 14.3 2.0 0.03 14.3 1.4 4.1 1 1 3 4 4 4 0 Domain of unknown function (DUF4398) TPT PF03151.11 KOO25063.1 - 4.5e-09 36.1 13.8 4.5e-09 36.1 9.5 2.0 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 KOO25063.1 - 0.00081 19.4 30.9 0.018 15.1 9.9 2.3 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.6 KOO25063.1 - 0.0024 16.8 18.5 0.0031 16.4 12.8 1.1 1 0 0 1 1 1 1 UAA transporter family Phage_holin_2 PF04550.7 KOO25063.1 - 0.06 13.4 0.1 0.17 11.9 0.1 1.8 1 0 0 1 1 1 0 Phage holin family 2 EmrE PF13536.1 KOO25063.1 - 0.088 13.0 27.8 0.29 11.3 3.9 2.8 2 2 0 2 2 2 0 Multidrug resistance efflux transporter FHA PF00498.21 KOO25064.1 - 9.1e-10 38.5 0.0 2.4e-09 37.1 0.0 1.7 2 0 0 2 2 2 1 FHA domain SAP PF02037.22 KOO25064.1 - 8.6e-05 21.9 0.2 0.00024 20.4 0.2 1.8 1 0 0 1 1 1 1 SAP domain LRR_6 PF13516.1 KOO25065.1 - 2.1e-24 82.7 27.0 0.021 14.8 0.2 13.1 12 0 0 12 12 11 7 Leucine Rich repeat LRR_1 PF00560.28 KOO25065.1 - 2.3e-11 42.0 9.7 25 5.4 0.2 12.0 13 0 0 13 13 12 0 Leucine Rich Repeat LRR_4 PF12799.2 KOO25065.1 - 2.6e-11 42.8 16.1 0.49 10.0 0.0 8.9 8 1 0 8 8 8 4 Leucine Rich repeats (2 copies) EF-hand_1 PF00036.27 KOO25065.1 - 4.8e-11 41.1 0.5 2.8e-05 23.1 0.1 2.8 3 0 0 3 3 2 2 EF hand LRR_8 PF13855.1 KOO25065.1 - 1.6e-08 34.1 15.3 5.4 6.8 0.0 10.1 8 2 1 9 9 9 1 Leucine rich repeat EF-hand_7 PF13499.1 KOO25065.1 - 2e-08 34.2 0.1 5.7e-08 32.7 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO25065.1 - 3.3e-07 29.6 0.0 0.039 13.8 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain PDZ_2 PF13180.1 KOO25065.1 - 1.1e-05 25.1 0.0 2.5e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain EF-hand_5 PF13202.1 KOO25065.1 - 3.1e-05 23.1 0.2 0.2 11.0 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO25065.1 - 0.0002 20.8 1.0 0.00077 19.0 0.3 2.3 2 1 1 3 3 3 1 EF-hand domain pair LRR_7 PF13504.1 KOO25065.1 - 0.0018 18.1 25.1 55 4.6 0.0 10.8 11 0 0 11 11 9 0 Leucine rich repeat EF-hand_4 PF12763.2 KOO25065.1 - 0.0069 16.1 0.5 0.026 14.2 0.1 2.0 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO25065.1 - 0.0077 16.1 0.0 0.016 15.1 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain Parecho_VpG PF06344.6 KOO25065.1 - 0.039 13.8 3.6 17 5.5 0.1 3.9 3 0 0 3 3 3 0 Parechovirus Genome-linked protein KxDL PF10241.4 KOO25065.1 - 0.18 11.7 0.0 0.57 10.1 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein Laminin_G_3 PF13385.1 KOO25066.1 - 2e-05 24.8 0.0 4.9e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily CopD PF05425.8 KOO25066.1 - 0.00015 21.9 0.8 0.03 14.5 0.1 3.4 3 0 0 3 3 3 2 Copper resistance protein D Abhydrolase_6 PF12697.2 KOO25067.1 - 5.7e-21 75.4 1.6 6.5e-21 75.2 1.1 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO25067.1 - 5.9e-09 35.8 0.1 6.4e-09 35.7 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 KOO25067.1 - 0.033 14.0 0.0 0.052 13.3 0.0 1.3 1 0 0 1 1 1 0 Putative lysophospholipase Ser_hydrolase PF06821.8 KOO25067.1 - 0.047 13.2 0.0 0.057 13.0 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase Abhydrolase_1 PF00561.15 KOO25067.1 - 0.06 12.8 0.0 0.067 12.7 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold PH PF00169.24 KOO25068.1 - 0.00069 19.7 0.0 0.0012 18.9 0.0 1.4 1 0 0 1 1 1 1 PH domain BAR PF03114.13 KOO25068.1 - 0.014 14.8 1.8 0.024 14.1 0.6 1.8 2 0 0 2 2 2 0 BAR domain FGE-sulfatase PF03781.11 KOO25069.1 - 6.1e-62 209.3 3.9 9.2e-62 208.7 2.7 1.2 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 Helicase_C PF00271.26 KOO25070.1 - 3.3e-10 39.6 0.0 7e-10 38.6 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PDZ_1 PF12812.2 KOO25071.1 - 9.9e-24 83.0 0.0 3.7e-20 71.6 0.0 3.1 3 0 0 3 3 3 2 PDZ-like domain Trypsin_2 PF13365.1 KOO25071.1 - 6.8e-16 58.3 0.1 2.6e-14 53.2 0.0 2.4 2 0 0 2 2 2 1 Trypsin-like peptidase domain PDZ_2 PF13180.1 KOO25071.1 - 1.3e-09 37.8 0.0 0.0025 17.6 0.0 3.9 4 0 0 4 4 4 2 PDZ domain Trypsin PF00089.21 KOO25071.1 - 3.8e-06 26.6 0.0 8.6e-05 22.2 0.0 2.3 2 0 0 2 2 2 1 Trypsin PDZ PF00595.19 KOO25071.1 - 0.00058 19.9 0.0 0.16 12.1 0.0 3.0 3 0 0 3 3 3 1 PDZ domain (Also known as DHR or GLGF) Peptidase_S7 PF00949.16 KOO25071.1 - 0.0049 16.2 0.4 0.011 15.0 0.3 1.5 1 0 0 1 1 1 1 Peptidase S7, Flavivirus NS3 serine protease Peptidase_S46 PF10459.4 KOO25071.1 - 0.012 14.0 0.2 0.023 13.1 0.1 1.3 1 0 0 1 1 1 0 Peptidase S46 DUF31 PF01732.11 KOO25071.1 - 0.12 11.7 1.0 0.21 10.8 0.7 1.4 1 0 0 1 1 1 0 Putative peptidase (DUF31) HSCB_C PF07743.8 KOO25072.1 - 4.2e-12 46.3 4.9 4.6e-12 46.2 3.4 1.0 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain PolyA_pol_RNAbd PF12627.2 KOO25072.1 - 0.004 16.6 0.6 0.011 15.2 0.1 1.7 2 0 0 2 2 2 1 Probable RNA and SrmB- binding site of polymerase A FUSC PF04632.7 KOO25072.1 - 0.51 8.6 2.3 0.55 8.6 1.6 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF1079 PF06435.6 KOO25076.1 - 0.0068 16.2 1.2 2.5 8.1 0.1 3.7 4 0 0 4 4 4 1 Repeat of unknown function (DUF1079) Phage_integ_N PF09003.5 KOO25076.1 - 0.1 12.3 0.4 0.2 11.3 0.1 1.7 1 1 1 2 2 2 0 Bacteriophage lambda integrase, N-terminal domain Tctex-1 PF03645.8 KOO25077.1 - 0.059 13.2 0.2 0.078 12.8 0.1 1.3 1 0 0 1 1 1 0 Tctex-1 family Isochorismatase PF00857.15 KOO25078.1 - 5.7e-29 101.2 0.4 7.2e-28 97.6 0.3 2.1 1 1 0 1 1 1 1 Isochorismatase family EF-hand_1 PF00036.27 KOO25078.1 - 4.8e-12 44.2 0.2 2.8e-05 23.0 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO25078.1 - 6.1e-11 41.1 0.2 0.00032 19.9 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO25078.1 - 1.9e-10 40.7 0.4 3.2e-10 40.0 0.3 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO25078.1 - 2.8e-10 39.1 0.1 0.00017 21.2 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO25078.1 - 8.8e-08 31.6 0.5 2.8e-07 30.0 0.2 1.9 1 1 1 2 2 2 2 EF-hand domain pair polyprenyl_synt PF00348.12 KOO25079.1 - 3.8e-51 173.4 0.4 4.8e-51 173.1 0.2 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase HEPPP_synt_1 PF07307.6 KOO25079.1 - 0.00055 19.4 0.3 0.00073 19.0 0.2 1.1 1 0 0 1 1 1 1 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 Bromodomain PF00439.20 KOO25080.1 - 1.9e-19 69.3 0.1 4.8e-19 68.0 0.1 1.7 2 0 0 2 2 2 1 Bromodomain Acetyltransf_7 PF13508.1 KOO25080.1 - 3.2e-12 46.4 0.4 7e-12 45.3 0.3 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 KOO25080.1 - 7.5e-12 45.1 0.1 1.7e-11 43.9 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 KOO25080.1 - 1.3e-05 25.3 0.0 3.6e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 KOO25080.1 - 0.0036 17.2 0.1 0.038 13.9 0.0 2.4 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 KOO25080.1 - 0.0048 16.7 0.1 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 KOO25080.1 - 0.037 13.7 0.0 0.093 12.4 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Ribosomal_60s PF00428.14 KOO25081.1 - 0.26 11.6 3.1 0.56 10.6 2.2 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein MTHFR PF02219.12 KOO25082.1 - 3.6e-35 121.4 0.0 5.2e-35 120.9 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase ApbA_C PF08546.6 KOO25083.1 - 3.5e-15 56.1 0.0 4.7e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal Orexin PF02072.10 KOO25083.1 - 0.085 12.6 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Prepro-orexin EF-hand_7 PF13499.1 KOO25084.1 - 1.5e-25 89.1 5.9 5.8e-07 29.5 0.2 4.8 5 0 0 5 5 5 4 EF-hand domain pair EF-hand_1 PF00036.27 KOO25084.1 - 3.8e-25 85.2 19.4 9e-05 21.5 0.3 6.6 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.1 KOO25084.1 - 8.6e-19 65.6 16.6 0.0006 19.4 0.3 6.6 6 0 0 6 6 6 6 EF-hand domain EF-hand_8 PF13833.1 KOO25084.1 - 1.4e-11 43.8 13.4 0.013 15.0 0.4 5.6 6 0 0 6 6 6 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO25084.1 - 4.9e-06 25.6 21.1 0.0043 16.3 0.6 6.3 6 0 0 6 6 6 3 EF hand TruB_C PF09142.6 KOO25084.1 - 0.023 14.3 0.6 3.2 7.4 0.1 3.0 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal EF-hand_4 PF12763.2 KOO25084.1 - 0.52 10.0 6.5 1.2 8.8 0.1 3.3 2 1 2 4 4 4 0 Cytoskeletal-regulatory complex EF hand Peptidase_M14 PF00246.19 KOO25085.1 - 2.1e-25 89.8 0.1 1.1e-24 87.5 0.0 1.8 1 1 1 2 2 2 1 Zinc carboxypeptidase AstE_AspA PF04952.9 KOO25085.1 - 0.00039 19.3 0.0 0.00063 18.7 0.0 1.3 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family RNase_PH PF01138.16 KOO25088.1 - 1e-10 41.9 0.4 1.7e-10 41.3 0.0 1.5 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 CBFD_NFYB_HMF PF00808.18 KOO25089.1 - 5.1e-05 23.2 0.5 8.7e-05 22.5 0.3 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 KOO25089.1 - 0.017 15.2 0.9 0.075 13.1 0.2 1.9 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 Bromo_coat PF01318.13 KOO25089.1 - 0.08 12.6 0.1 0.19 11.4 0.0 1.6 1 1 1 2 2 2 0 Bromovirus coat protein CBFD_NFYB_HMF PF00808.18 KOO25090.1 - 1.3e-05 25.1 0.0 2e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 KOO25090.1 - 0.014 15.4 0.0 0.024 14.7 0.0 1.4 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Peptidase_C1 PF00112.18 KOO25093.1 - 5.3e-18 65.6 2.8 7.1e-18 65.2 1.9 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1 PF00112.18 KOO25094.1 - 9.9e-27 94.2 4.0 1.3e-26 93.8 2.7 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.10 KOO25094.1 - 0.0031 16.1 1.5 0.0037 15.8 1.0 1.1 1 0 0 1 1 1 1 Peptidase C1-like family Thioredoxin PF00085.15 KOO25095.1 - 1.1e-25 89.3 0.0 3.2e-20 71.7 0.0 4.2 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.1 KOO25095.1 - 3e-17 63.0 0.0 6.3e-07 29.3 0.0 3.2 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 KOO25095.1 - 9.5e-05 22.4 0.0 0.032 14.3 0.0 3.4 3 0 0 3 3 3 1 Thioredoxin-like HyaE PF07449.6 KOO25095.1 - 0.00042 20.1 0.1 0.012 15.5 0.0 3.2 3 0 0 3 3 3 1 Hydrogenase-1 expression protein HyaE Thioredoxin_2 PF13098.1 KOO25095.1 - 0.0011 19.1 5.2 0.97 9.6 0.1 4.3 4 1 0 4 4 4 2 Thioredoxin-like domain Thioredoxin_7 PF13899.1 KOO25095.1 - 0.0068 16.4 0.0 0.024 14.6 0.0 2.0 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_3 PF13192.1 KOO25095.1 - 0.017 14.9 0.1 0.24 11.2 0.0 2.8 3 0 0 3 3 3 0 Thioredoxin domain AhpC-TSA PF00578.16 KOO25095.1 - 0.032 13.9 0.1 0.15 11.7 0.0 2.1 2 0 0 2 2 2 0 AhpC/TSA family Thioredoxin_4 PF13462.1 KOO25095.1 - 0.6 10.0 0.0 0.6 10.0 0.0 3.1 3 1 0 3 3 3 0 Thioredoxin CENP-F_leu_zip PF10473.4 KOO25097.1 - 0.0028 17.5 5.8 0.0028 17.5 4.0 3.0 3 1 0 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Lzipper-MIP1 PF14389.1 KOO25097.1 - 0.018 15.1 10.0 0.19 11.8 3.7 3.1 2 1 1 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 IFP_35_N PF07334.8 KOO25097.1 - 0.18 11.8 1.0 3.1 7.8 0.1 2.4 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Phage_Mu_Gam PF07352.7 KOO25097.1 - 0.19 11.2 1.6 0.48 9.9 1.1 1.6 1 1 0 1 1 1 0 Bacteriophage Mu Gam like protein ADIP PF11559.3 KOO25097.1 - 0.7 9.7 9.5 1.3 8.9 0.5 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Kinetocho_Slk19 PF12709.2 KOO25097.1 - 0.84 9.7 4.7 27 4.9 0.2 3.1 3 0 0 3 3 3 0 Central kinetochore-associated DivIVA PF05103.8 KOO25097.1 - 1.1 9.3 7.4 1.7 8.6 3.9 2.0 1 1 1 2 2 2 0 DivIVA protein DivIC PF04977.10 KOO25097.1 - 1.9 7.9 8.6 5 6.6 0.5 3.2 3 0 0 3 3 3 0 Septum formation initiator Macoilin PF09726.4 KOO25097.1 - 2 6.6 10.8 8.2 4.5 7.4 1.8 1 1 0 1 1 1 0 Transmembrane protein TACC PF05010.9 KOO25097.1 - 3.1 7.5 8.9 0.52 10.0 3.3 1.8 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC) GAS PF13851.1 KOO25097.1 - 3.3 6.8 7.4 4.2 6.5 0.4 2.9 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding Fez1 PF06818.10 KOO25097.1 - 3.6 7.5 17.7 0.7 9.8 1.9 2.7 1 1 1 2 2 2 0 Fez1 HALZ PF02183.13 KOO25097.1 - 6.7 6.5 13.5 2.9 7.6 0.6 4.0 3 1 0 3 3 3 0 Homeobox associated leucine zipper Aldo_ket_red PF00248.16 KOO25098.1 - 1.7e-45 155.0 0.0 2.4e-45 154.5 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Bestrophin PF01062.16 KOO25099.1 - 1.2e-38 132.7 3.2 1.6e-38 132.3 2.2 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Exostosin PF03016.10 KOO25100.1 - 1.1e-25 90.2 0.1 6.6e-23 81.2 0.0 2.1 1 1 0 2 2 2 2 Exostosin family EF-hand_7 PF13499.1 KOO25101.1 - 9.4e-14 51.3 0.2 7.5e-13 48.4 0.3 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO25101.1 - 2.9e-12 44.9 0.6 2.2e-05 23.4 0.1 2.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO25101.1 - 4.5e-12 45.3 1.2 1.5e-08 34.0 0.0 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO25101.1 - 1.2e-11 43.4 1.0 7.3e-06 25.4 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO25101.1 - 2.8e-07 29.5 0.6 0.0013 17.9 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.1 KOO25101.1 - 0.036 13.9 0.0 1.9 8.4 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO25101.1 - 0.061 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO25101.1 - 0.11 12.2 0.4 0.33 10.6 0.0 2.0 2 0 0 2 2 2 0 EF hand TBPIP PF07106.8 KOO25102.1 - 0.011 15.2 0.4 0.014 14.9 0.3 1.2 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) CCDC-167 PF15188.1 KOO25102.1 - 0.045 13.6 1.3 0.08 12.8 0.9 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF342 PF03961.8 KOO25102.1 - 0.049 12.0 0.7 0.056 11.8 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) ALIX_LYPXL_bnd PF13949.1 KOO25102.1 - 0.093 11.6 2.0 0.12 11.2 1.4 1.1 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV GvpG PF05120.7 KOO25102.1 - 0.24 11.2 5.4 0.44 10.3 3.7 1.4 1 0 0 1 1 1 0 Gas vesicle protein G FlgM PF04316.8 KOO25102.1 - 0.26 11.2 2.1 0.31 11.0 0.5 1.9 2 0 0 2 2 2 0 Anti-sigma-28 factor, FlgM Prefoldin_2 PF01920.15 KOO25102.1 - 2.1 8.1 7.2 0.32 10.7 1.4 2.0 1 1 0 2 2 2 0 Prefoldin subunit Spc24 PF08286.6 KOO25102.1 - 4.3 7.0 5.6 2.1 8.0 0.5 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF4337 PF14235.1 KOO25102.1 - 5.3 6.8 8.2 27 4.5 5.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) Hydrolase_like PF13242.1 KOO25103.1 - 7.1e-13 48.0 0.0 8.6e-11 41.3 0.0 3.2 2 2 1 3 3 3 1 HAD-hyrolase-like Hydrolase_6 PF13344.1 KOO25103.1 - 7.3e-11 41.8 0.0 3.4e-10 39.6 0.0 2.2 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase LRR_4 PF12799.2 KOO25104.1 - 1.6e-22 78.6 42.5 3.4e-07 29.7 1.3 9.8 7 1 2 10 10 10 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO25104.1 - 1.8e-14 53.2 45.9 6.1e-09 35.5 1.0 8.2 7 3 1 8 8 8 3 Leucine rich repeat LRR_6 PF13516.1 KOO25104.1 - 2.9e-08 32.9 40.4 0.0012 18.7 0.0 13.0 14 1 1 15 15 15 2 Leucine Rich repeat LRR_1 PF00560.28 KOO25104.1 - 1.4e-07 30.5 31.2 4.6 7.6 0.0 13.6 15 1 1 16 16 16 3 Leucine Rich Repeat SH3_3 PF08239.6 KOO25104.1 - 4.9e-06 26.6 1.3 1.5 9.0 0.0 5.2 6 0 0 6 6 6 1 Bacterial SH3 domain Ras PF00071.17 KOO25104.1 - 1.2e-05 24.7 0.0 0.00015 21.1 0.0 2.3 2 0 0 2 2 2 1 Ras family Miro PF08477.8 KOO25104.1 - 0.0062 17.0 0.0 0.016 15.7 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein NB-ARC PF00931.17 KOO25104.1 - 0.047 12.5 0.0 0.11 11.3 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain LRR_7 PF13504.1 KOO25104.1 - 0.052 13.7 32.7 17 6.1 0.1 12.0 14 0 0 14 14 14 0 Leucine rich repeat LMBR1 PF04791.11 KOO25104.1 - 9 4.7 5.8 20 3.5 4.0 1.5 1 0 0 1 1 1 0 LMBR1-like membrane protein Phospholip_B PF04916.8 KOO25105.1 - 1.3e-88 297.4 0.0 1.8e-88 297.0 0.0 1.0 1 0 0 1 1 1 1 Phospholipase B Nucleotid_trans PF03407.11 KOO25106.1 - 1.9e-38 132.3 0.0 2.6e-38 131.9 0.0 1.1 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase SNARE PF05739.14 KOO25107.1 - 2.1e-10 40.1 4.3 2.8e-10 39.7 3.0 1.2 1 0 0 1 1 1 1 SNARE domain DUF607 PF04678.8 KOO25107.1 - 0.04 13.8 0.1 0.042 13.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF607 Tropomyosin_1 PF12718.2 KOO25107.1 - 0.05 13.4 1.9 0.14 11.9 1.5 1.4 1 1 0 1 1 1 0 Tropomyosin like PRRSV_2b PF07069.6 KOO25107.1 - 0.052 13.8 0.2 0.078 13.2 0.1 1.3 1 0 0 1 1 1 0 Porcine reproductive and respiratory syndrome virus 2b COG5 PF10392.4 KOO25107.1 - 0.064 13.2 0.0 0.19 11.6 0.0 1.6 1 1 1 2 2 2 0 Golgi transport complex subunit 5 SlyX PF04102.7 KOO25107.1 - 0.086 13.2 3.1 0.11 12.9 0.7 1.9 1 1 1 2 2 2 0 SlyX Mst1_SARAH PF11629.3 KOO25107.1 - 0.18 11.6 1.2 1.4 8.7 0.0 2.6 1 1 2 3 3 3 0 C terminal SARAH domain of Mst1 zf-CXXC PF02008.15 KOO25108.1 - 5.5e-11 42.0 18.0 8.9e-11 41.4 12.5 1.3 1 0 0 1 1 1 1 CXXC zinc finger domain Glyco_trans_1_3 PF13528.1 KOO25109.1 - 8.5e-24 84.3 0.0 1.3e-23 83.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 1 Glyco_tran_28_C PF04101.11 KOO25109.1 - 0.01 15.4 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain UDPGT PF00201.13 KOO25109.1 - 0.016 13.8 0.0 0.025 13.1 0.0 1.2 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase CEP44 PF15007.1 KOO25110.1 - 3.9e-36 123.6 0.0 6.6e-36 122.9 0.0 1.4 1 0 0 1 1 1 1 Centrosomal spindle body, CEP44 IPK PF03770.11 KOO25111.1 - 0.029 13.9 0.0 0.044 13.4 0.0 1.3 1 0 0 1 1 1 0 Inositol polyphosphate kinase MatE PF01554.13 KOO25112.1 - 1.5e-18 66.9 33.0 2.4e-09 37.0 8.6 2.5 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.1 KOO25112.1 - 3.1e-06 27.0 1.4 3.1e-06 27.0 0.9 4.1 3 1 0 4 4 4 1 Polysaccharide biosynthesis C-terminal domain Mur_ligase_M PF08245.7 KOO25113.1 - 5.1e-10 39.7 0.0 1.2e-09 38.5 0.0 1.6 1 1 0 1 1 1 1 Mur ligase middle domain Nucleotid_trans PF03407.11 KOO25114.1 - 0.00021 21.1 0.0 0.00026 20.8 0.0 1.3 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase PAN_1 PF00024.21 KOO25115.1 - 3.3e-15 55.5 15.5 9e-05 22.1 0.6 3.4 3 0 0 3 3 3 3 PAN domain PAN_4 PF14295.1 KOO25115.1 - 1.1e-10 41.0 21.8 3.7e-05 23.3 0.5 3.8 4 0 0 4 4 4 3 PAN domain CD99L2 PF12301.3 KOO25115.1 - 0.83 9.3 4.8 3.6 7.2 0.0 2.8 3 0 0 3 3 3 0 CD99 antigen like protein 2 MANEC PF07502.9 KOO25115.1 - 2 8.5 15.3 2 8.4 1.6 3.6 3 0 0 3 3 3 0 MANEC domain DUF4116 PF13475.1 KOO25116.1 - 5.9e-142 461.0 0.0 1.6e-15 56.2 0.0 9.2 4 2 8 12 12 12 12 Domain of unknown function (DUF4116) Rsbr_N PF08678.5 KOO25116.1 - 6.4e-06 26.0 0.0 18 5.1 0.0 6.1 1 1 4 7 7 7 2 Rsbr N terminal gpW PF02831.10 KOO25116.1 - 5e-05 22.7 2.8 0.45 10.0 0.0 5.0 3 2 2 5 5 5 2 gpW PRA-CH PF01502.13 KOO25116.1 - 0.00027 20.5 0.2 22 4.7 0.0 6.1 4 2 4 8 8 8 1 Phosphoribosyl-AMP cyclohydrolase Chlor_dismutase PF06778.7 KOO25116.1 - 0.00038 20.2 3.0 8.9 5.9 0.0 4.9 2 2 4 6 6 6 1 Chlorite dismutase Phage_Gp111 PF07410.6 KOO25116.1 - 3.4 7.8 7.1 2.3e+02 2.0 0.0 5.8 2 2 5 7 7 7 0 Streptococcus thermophilus bacteriophage Gp111 protein Fib_alpha PF08702.5 KOO25117.1 - 0.0071 16.4 6.2 0.0071 16.4 4.3 2.7 1 1 1 2 2 2 1 Fibrinogen alpha/beta chain family IQ PF00612.22 KOO25117.1 - 0.081 12.6 0.2 0.29 10.9 0.0 2.0 2 0 0 2 2 2 0 IQ calmodulin-binding motif Reo_sigmaC PF04582.7 KOO25117.1 - 0.8 8.8 3.3 1.4 7.9 0.5 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein ACR_tran PF00873.14 KOO25117.1 - 0.97 6.7 6.9 1.3 6.3 4.8 1.2 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Calpain_III PF01067.17 KOO25118.1 - 1.9e-35 121.6 0.0 2.7e-13 49.8 0.0 3.4 3 0 0 3 3 3 3 Calpain large subunit, domain III Peptidase_C2 PF00648.16 KOO25118.1 - 4e-35 121.2 0.0 5.7e-35 120.7 0.0 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease DUF4399 PF14347.1 KOO25118.1 - 0.032 14.2 0.0 0.074 13.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4399) Polyketide_cyc PF03364.15 KOO25119.1 - 2e-12 47.2 0.0 2.3e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.4 KOO25119.1 - 6.4e-09 36.1 0.0 8.7e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport PHF5 PF03660.9 KOO25120.1 - 2.5e-49 165.7 13.7 2.8e-49 165.6 9.5 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.8 KOO25120.1 - 0.64 7.6 9.1 0.66 7.5 6.3 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.2 KOO25120.1 - 3.3 7.6 19.9 0.22 11.3 2.5 3.0 1 1 2 3 3 3 0 Double zinc ribbon Glyco_hydro_6 PF01341.12 KOO25121.1 - 4.1e-68 230.0 0.0 2.7e-67 227.3 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 6 Arm PF00514.18 KOO25122.1 - 8.7e-12 44.4 10.6 1.2e-05 24.8 0.1 5.2 3 2 1 4 4 4 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 KOO25122.1 - 0.049 14.1 11.5 0.22 12.0 3.6 3.0 3 0 0 3 3 3 0 HEAT-like repeat HEAT_2 PF13646.1 KOO25122.1 - 0.36 11.1 12.7 12 6.3 1.0 3.4 1 1 2 3 3 3 0 HEAT repeats Exostosin PF03016.10 KOO25123.1 - 1.3e-20 73.6 0.1 7.9e-20 71.1 0.1 1.9 1 1 0 1 1 1 1 Exostosin family MoeA_N PF03453.12 KOO25125.1 - 1.4e-41 141.5 1.4 2.1e-41 140.9 1.0 1.2 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoCF_biosynth PF00994.19 KOO25125.1 - 3.4e-22 78.4 0.0 5.5e-22 77.7 0.0 1.4 1 0 0 1 1 1 1 Probable molybdopterin binding domain MoeA_C PF03454.10 KOO25125.1 - 2.6e-14 52.8 0.1 6.8e-14 51.5 0.0 1.7 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) Methyltransf_4 PF02390.12 KOO25126.1 - 5.7e-37 126.6 0.0 6.8e-37 126.4 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 KOO25126.1 - 5.8e-08 33.3 0.0 1.2e-07 32.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO25126.1 - 2.6e-06 27.4 0.2 3.9e-06 26.8 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO25126.1 - 1.4e-05 24.9 0.0 0.00044 19.9 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO25126.1 - 2.8e-05 23.7 0.1 4.7e-05 23.0 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO25126.1 - 0.00016 22.0 0.1 0.022 15.2 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 KOO25126.1 - 0.00085 18.7 0.0 0.0013 18.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.7 KOO25126.1 - 0.013 15.9 0.1 0.27 11.7 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.1 KOO25126.1 - 0.042 14.2 0.1 0.093 13.0 0.0 1.7 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_32 PF13679.1 KOO25126.1 - 0.13 11.9 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Orai-1 PF07856.7 KOO25127.1 - 7.5e-05 22.3 9.1 0.00052 19.6 6.3 2.0 1 1 0 1 1 1 1 Mediator of CRAC channel activity CLAMP PF14769.1 KOO25129.1 - 9.5e-28 96.3 2.6 1.6e-27 95.5 1.8 1.4 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 HpaP PF09483.5 KOO25129.1 - 2 8.3 8.1 3.6 7.4 5.6 1.3 1 0 0 1 1 1 0 Type III secretion protein (HpaP) KR PF08659.5 KOO25130.1 - 0.0025 17.4 0.1 0.0048 16.5 0.1 1.4 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 KOO25130.1 - 0.0029 17.5 0.2 0.0029 17.5 0.1 2.3 2 0 0 2 2 2 1 short chain dehydrogenase 3Beta_HSD PF01073.14 KOO25130.1 - 0.065 11.9 0.0 0.096 11.3 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Myb_DNA-binding PF00249.26 KOO25132.1 - 1.9e-20 72.6 0.5 1.4e-09 37.8 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO25132.1 - 3.4e-15 55.8 0.3 3.5e-06 27.0 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Peptidase_M16 PF00675.15 KOO25133.1 - 7.6e-21 74.4 0.1 6.8e-10 38.8 0.0 2.6 2 0 0 2 2 2 2 Insulinase (Peptidase family M16) IGR PF09597.5 KOO25133.1 - 0.005 16.7 0.1 2.7 7.9 0.0 2.4 2 0 0 2 2 2 2 IGR protein motif DUF1583 PF07622.6 KOO25133.1 - 0.18 10.1 0.2 12 4.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1583) Colicin_Ia PF11504.3 KOO25133.1 - 0.63 9.9 3.4 38 4.2 0.1 3.5 1 1 2 3 3 3 0 Colicin Ia 2OG-FeII_Oxy PF03171.15 KOO25134.1 - 1e-16 61.0 0.0 1.6e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.1 KOO25134.1 - 1.7e-08 34.9 0.0 3.3e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Ras PF00071.17 KOO25135.1 - 1e-56 190.7 0.0 1.4e-56 190.3 0.0 1.2 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO25135.1 - 9.9e-19 67.9 0.0 1.4e-18 67.5 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO25135.1 - 5.3e-10 38.8 0.0 6e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 KOO25135.1 - 1.1e-05 24.9 0.0 6.3e-05 22.4 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOO25135.1 - 2.7e-05 24.1 0.0 3.4e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 KOO25135.1 - 0.0015 17.8 0.0 0.0025 17.0 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.12 KOO25135.1 - 0.0078 15.7 0.6 0.17 11.4 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein FeoB_N PF02421.13 KOO25135.1 - 0.011 15.0 0.0 0.037 13.2 0.0 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B Septin PF00735.13 KOO25135.1 - 0.012 14.6 0.5 0.055 12.4 0.0 2.1 3 0 0 3 3 3 0 Septin AAA_25 PF13481.1 KOO25135.1 - 0.038 13.3 0.4 0.14 11.5 0.2 1.9 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.11 KOO25135.1 - 0.066 12.3 0.0 0.11 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AIG1 PF04548.11 KOO25135.1 - 0.12 11.5 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 AIG1 family Rubredoxin PF00301.15 KOO25136.1 - 3.9e-12 45.8 4.9 5.7e-12 45.3 3.4 1.3 1 0 0 1 1 1 1 Rubredoxin HypA PF01155.14 KOO25136.1 - 0.0036 16.9 0.1 0.0088 15.7 0.1 1.5 1 1 0 1 1 1 1 Hydrogenase expression/synthesis hypA family TF_Zn_Ribbon PF08271.7 KOO25136.1 - 0.092 12.0 0.4 1.2 8.5 0.0 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding zinc_ribbon_4 PF13717.1 KOO25136.1 - 0.22 11.2 2.2 5.2 6.8 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 KOO25136.1 - 0.22 11.1 2.0 6.2 6.4 0.0 2.3 2 0 0 2 2 2 0 zinc-ribbon domain TFIIS_C PF01096.13 KOO25136.1 - 0.3 10.7 4.4 2.7 7.7 0.2 2.4 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) adh_short_C2 PF13561.1 KOO25137.1 - 2.1e-28 99.7 0.0 3e-28 99.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 KOO25137.1 - 2.7e-25 89.2 1.5 3.8e-25 88.7 1.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOO25137.1 - 8.7e-09 35.2 1.2 1.4e-08 34.5 0.9 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 KOO25137.1 - 4.1e-05 23.6 0.2 0.0001 22.3 0.1 1.5 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 KOO25137.1 - 0.00068 19.1 0.3 0.0036 16.7 0.2 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.14 KOO25137.1 - 0.093 11.8 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Herpes_UL51 PF04540.8 KOO25137.1 - 0.14 11.7 0.8 0.21 11.1 0.6 1.2 1 0 0 1 1 1 0 Herpesvirus UL51 protein DUF1049 PF06305.6 KOO25137.1 - 0.65 9.5 2.9 1.3 8.5 2.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Herpes_UL43 PF05072.8 KOO25138.1 - 0.02 13.6 0.3 0.03 13.0 0.2 1.2 1 0 0 1 1 1 0 Herpesvirus UL43 protein Cecropin PF00272.14 KOO25138.1 - 0.11 12.0 1.8 0.31 10.6 0.0 2.5 2 0 0 2 2 2 0 Cecropin family DnaJ PF00226.26 KOO25140.1 - 1e-15 57.2 0.3 2.2e-15 56.1 0.0 1.8 2 0 0 2 2 2 1 DnaJ domain C2 PF00168.25 KOO25141.1 - 2.3e-17 62.5 0.0 4.3e-17 61.7 0.0 1.5 1 0 0 1 1 1 1 C2 domain Ion_trans PF00520.26 KOO25141.1 - 3e-12 46.2 3.0 3e-12 46.2 2.1 1.7 2 0 0 2 2 2 1 Ion transport protein cNMP_binding PF00027.24 KOO25141.1 - 0.0024 17.6 0.0 0.0047 16.6 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_N PF08412.5 KOO25141.1 - 0.022 14.0 0.1 0.052 12.8 0.1 1.6 1 0 0 1 1 1 0 Ion transport protein N-terminal Aldo_ket_red PF00248.16 KOO25142.1 - 2.8e-33 114.9 0.0 6.5e-31 107.2 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family A_deaminase PF00962.17 KOO25143.1 - 1.4e-66 224.7 0.0 1.7e-66 224.4 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase DHC_N2 PF08393.8 KOO25144.1 - 4.4e-121 404.2 0.0 9.4e-121 403.1 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 KOO25144.1 - 3.2e-85 285.3 0.0 1e-84 283.7 0.0 1.8 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_7 PF12775.2 KOO25144.1 - 2.9e-54 183.9 0.0 6.6e-54 182.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_8 PF12780.2 KOO25144.1 - 1.1e-36 126.1 0.1 3.5e-36 124.5 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_5 PF07728.9 KOO25144.1 - 6.8e-18 64.7 0.0 4.5e-06 26.4 0.0 5.4 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA PF00004.24 KOO25144.1 - 6.2e-07 29.6 0.0 0.056 13.6 0.0 4.2 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO25144.1 - 2.9e-05 24.1 0.0 0.39 10.6 0.0 4.4 4 0 0 4 4 4 1 AAA ATPase domain AAA_22 PF13401.1 KOO25144.1 - 0.00039 20.5 0.7 0.14 12.2 0.0 3.9 5 0 0 5 5 3 1 AAA domain RNA_helicase PF00910.17 KOO25144.1 - 0.00063 19.8 0.1 2.1 8.5 0.0 3.6 3 0 0 3 3 3 2 RNA helicase AAA_19 PF13245.1 KOO25144.1 - 0.0013 18.3 0.1 1.2 8.9 0.0 2.9 2 0 0 2 2 2 1 Part of AAA domain EF-hand_1 PF00036.27 KOO25144.1 - 0.0017 17.5 0.6 0.0072 15.5 0.4 2.2 1 0 0 1 1 1 1 EF hand T2SE PF00437.15 KOO25144.1 - 0.0023 16.8 0.4 0.031 13.1 0.0 2.6 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_14 PF13173.1 KOO25144.1 - 0.0024 17.7 0.0 1.4 8.8 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.1 KOO25144.1 - 0.0033 17.0 0.7 3.9 6.9 0.1 3.0 3 0 0 3 3 3 2 AAA domain AAA_25 PF13481.1 KOO25144.1 - 0.005 16.2 0.3 0.17 11.2 0.0 2.9 3 0 0 3 3 3 1 AAA domain UPF0079 PF02367.12 KOO25144.1 - 0.012 15.2 0.2 1.7 8.2 0.0 3.1 3 0 0 3 3 3 0 Uncharacterised P-loop hydrolase UPF0079 Sigma54_activat PF00158.21 KOO25144.1 - 0.013 14.9 0.0 0.4 10.1 0.0 3.0 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_17 PF13207.1 KOO25144.1 - 0.015 16.0 0.0 6.9 7.5 0.0 3.8 3 0 0 3 3 3 0 AAA domain EF-hand_6 PF13405.1 KOO25144.1 - 0.02 14.7 0.5 0.11 12.3 0.4 2.4 1 0 0 1 1 1 0 EF-hand domain NACHT PF05729.7 KOO25144.1 - 0.042 13.5 0.1 0.35 10.5 0.0 2.5 2 0 0 2 2 2 0 NACHT domain EF-hand_1 PF00036.27 KOO25145.1 - 1.5e-25 86.4 4.0 4.1e-06 25.7 0.0 6.7 6 0 0 6 6 6 4 EF hand EF-hand_7 PF13499.1 KOO25145.1 - 4.2e-25 87.6 2.2 7.2e-10 38.8 0.0 4.9 4 2 0 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO25145.1 - 2.5e-24 84.6 5.2 2.2e-05 23.9 0.0 6.2 5 2 2 7 7 7 5 EF-hand domain pair EF-hand_6 PF13405.1 KOO25145.1 - 3.6e-19 66.8 11.2 0.0065 16.2 0.0 7.1 8 0 0 8 8 8 4 EF-hand domain EF-hand_5 PF13202.1 KOO25145.1 - 9.6e-18 62.6 3.3 5.9e-05 22.2 0.0 5.1 4 0 0 4 4 4 4 EF hand SPARC_Ca_bdg PF10591.4 KOO25145.1 - 1.1e-05 25.3 0.6 0.0037 17.2 0.0 3.2 2 2 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO25145.1 - 0.014 15.1 0.7 0.14 11.9 0.1 2.9 4 0 0 4 4 4 0 Cytoskeletal-regulatory complex EF hand Herpes_UL37_1 PF03970.8 KOO25145.1 - 0.025 13.3 0.1 0.041 12.6 0.1 1.2 1 0 0 1 1 1 0 Herpesvirus UL37 tegument protein EF-hand_9 PF14658.1 KOO25145.1 - 0.046 13.6 0.2 13 5.7 0.0 3.9 4 0 0 4 4 4 0 EF-hand domain RRM_3 PF08777.6 KOO25145.1 - 0.063 13.1 0.3 0.47 10.3 0.0 2.6 1 1 1 2 2 2 0 RNA binding motif DUF2638 PF10937.3 KOO25146.1 - 0.35 11.8 4.7 9.1 7.3 0.4 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF2638) MTP18 PF10558.4 KOO25147.1 - 4.5e-22 78.5 2.0 8.6e-22 77.6 0.3 1.9 1 1 1 2 2 2 1 Mitochondrial 18 KDa protein (MTP18) DUF4228 PF14009.1 KOO25148.1 - 0.21 11.7 4.8 0.3 11.2 3.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) zf-PARP PF00645.13 KOO25149.1 - 2.5e-13 50.0 7.4 3.9e-10 39.8 1.1 2.3 1 1 1 2 2 2 2 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region Adeno_52K PF03052.10 KOO25149.1 - 0.019 14.1 0.1 0.067 12.4 0.0 1.8 2 0 0 2 2 2 0 Adenoviral protein L1 52/55-kDa NOB1_Zn_bind PF08772.6 KOO25151.1 - 1.3e-18 66.6 0.1 2.1e-18 65.9 0.1 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like DZR PF12773.2 KOO25151.1 - 0.026 14.3 0.6 0.045 13.5 0.4 1.3 1 0 0 1 1 1 0 Double zinc ribbon zf-NADH-PPase PF09297.6 KOO25151.1 - 0.067 12.7 2.6 2.2 7.8 0.2 2.7 3 0 0 3 3 3 0 NADH pyrophosphatase zinc ribbon domain RNA_POL_M_15KD PF02150.11 KOO25151.1 - 0.067 12.8 1.8 0.11 12.1 0.2 2.0 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit RecR PF02132.10 KOO25151.1 - 2.2 7.7 4.2 11 5.5 0.2 2.9 3 0 0 3 3 3 0 RecR protein Methyltransf_18 PF12847.2 KOO25154.1 - 6.1e-08 33.2 0.0 1.2e-07 32.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO25154.1 - 3.5e-07 30.0 0.0 6.3e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO25154.1 - 1.2e-06 28.8 0.0 2.6e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 KOO25154.1 - 4.5e-05 22.6 0.0 9e-05 21.6 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.7 KOO25154.1 - 0.00016 22.0 0.0 0.00028 21.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 KOO25154.1 - 0.00044 19.8 0.0 0.00073 19.1 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DOT1 PF08123.8 KOO25154.1 - 0.00097 18.5 0.0 0.0021 17.4 0.0 1.4 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_31 PF13847.1 KOO25154.1 - 0.0029 17.2 0.0 0.0042 16.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 KOO25154.1 - 0.0096 15.6 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO25154.1 - 0.073 13.1 0.1 0.16 12.0 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 KOO25155.1 - 2.6e-08 34.2 0.0 5.8e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO25155.1 - 3.8e-06 26.7 0.0 6.7e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DSBA PF01323.15 KOO25155.1 - 0.00011 21.8 0.0 0.00025 20.6 0.0 1.5 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Ubie_methyltran PF01209.13 KOO25155.1 - 0.0013 17.8 0.0 0.0022 17.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 KOO25155.1 - 0.0015 18.1 0.0 0.0026 17.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain N6_N4_Mtase PF01555.13 KOO25155.1 - 0.0049 16.3 0.0 0.0076 15.7 0.0 1.2 1 0 0 1 1 1 1 DNA methylase Methyltransf_12 PF08242.7 KOO25155.1 - 0.0051 17.2 0.0 0.013 15.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 KOO25155.1 - 0.014 14.7 0.0 0.029 13.7 0.0 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_25 PF13649.1 KOO25155.1 - 0.039 14.3 0.0 0.092 13.1 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Sod_Ni PF09055.6 KOO25156.1 - 1.4e-29 103.1 2.0 3.4e-29 101.8 1.4 1.6 1 0 0 1 1 1 1 Nickel-containing superoxide dismutase WD40 PF00400.27 KOO25157.1 - 1.2e-50 167.6 25.5 3.5e-10 39.3 0.1 11.9 13 0 0 13 13 13 6 WD domain, G-beta repeat Utp12 PF04003.7 KOO25157.1 - 3.8e-20 71.8 0.1 6.1e-20 71.1 0.1 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family PD40 PF07676.7 KOO25157.1 - 4e-06 26.3 1.9 0.25 11.0 0.0 6.6 9 0 0 9 9 9 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.1 KOO25157.1 - 5.1e-05 22.5 0.5 0.69 8.9 0.0 4.7 4 2 1 5 5 5 1 Neuroblastoma-amplified sequence, N terminal eIF2A PF08662.6 KOO25157.1 - 0.00062 19.5 0.0 2.9 7.5 0.0 3.9 3 1 2 5 5 5 2 Eukaryotic translation initiation factor eIF2A Hira PF07569.6 KOO25157.1 - 0.001 18.3 0.0 0.48 9.6 0.0 3.9 5 0 0 5 5 5 1 TUP1-like enhancer of split Nup160 PF11715.3 KOO25157.1 - 0.055 11.6 0.1 6.3 4.8 0.3 3.5 3 1 0 3 3 3 0 Nucleoporin Nup120/160 TFIIIC_delta PF12657.2 KOO25157.1 - 0.11 12.2 0.1 3.6 7.2 0.0 3.2 3 1 1 4 4 4 0 Transcription factor IIIC subunit delta N-term IKI3 PF04762.7 KOO25157.1 - 0.11 10.2 0.0 0.25 9.1 0.0 1.5 1 0 0 1 1 1 0 IKI3 family DPPIV_N PF00930.16 KOO25157.1 - 0.13 10.7 0.0 0.73 8.3 0.0 2.2 3 0 0 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region EF-hand_5 PF13202.1 KOO25158.1 - 7.2e-16 56.7 0.3 2.2e-07 29.9 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.27 KOO25158.1 - 1.2e-15 55.4 0.2 1.6e-06 26.9 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO25158.1 - 1.4e-14 52.5 0.2 4.3e-07 29.2 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO25158.1 - 2.3e-14 53.2 0.0 3.8e-14 52.5 0.0 1.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO25158.1 - 9.7e-11 41.1 1.5 1.4e-07 30.9 0.0 2.5 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO25158.1 - 0.00017 21.6 0.0 0.00023 21.1 0.0 1.2 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO25158.1 - 0.0026 17.4 0.4 0.26 11.0 0.0 2.2 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand DUF601 PF04642.7 KOO25158.1 - 0.018 14.4 1.3 0.023 14.0 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF601 EF-hand_9 PF14658.1 KOO25158.1 - 0.033 14.0 0.0 0.054 13.4 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain Ribosomal_L24e PF01246.15 KOO25159.1 - 2.2e-27 94.7 0.2 2.2e-27 94.7 0.2 2.0 2 0 0 2 2 2 1 Ribosomal protein L24e OTU PF02338.14 KOO25161.1 - 5e-06 27.1 0.0 0.028 14.9 0.0 2.4 2 0 0 2 2 2 2 OTU-like cysteine protease Peptidase_C65 PF10275.4 KOO25161.1 - 1.4e-05 24.6 0.0 0.03 13.6 0.0 2.1 2 0 0 2 2 2 2 Peptidase C65 Otubain Sel1 PF08238.7 KOO25162.1 - 3.7e-84 275.3 79.6 3.2e-08 33.9 2.7 12.0 12 0 0 12 12 12 12 Sel1 repeat ICAM_N PF03921.9 KOO25162.1 - 0.0029 17.0 0.0 72 2.9 0.0 5.3 8 0 0 8 8 8 0 Intercellular adhesion molecule (ICAM), N-terminal domain MOFRL PF05161.8 KOO25162.1 - 0.073 13.1 21.8 0.41 10.7 0.3 6.3 5 2 3 8 8 8 0 MOFRL family TPR_16 PF13432.1 KOO25164.1 - 5.8e-15 55.4 16.8 3.4e-05 24.3 3.1 4.4 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.1 KOO25164.1 - 1.3e-14 53.6 7.6 9.2e-05 22.0 0.0 4.1 2 1 1 3 3 3 3 TPR repeat TPR_12 PF13424.1 KOO25164.1 - 6.6e-12 45.1 6.8 0.0035 17.2 1.8 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO25164.1 - 1.8e-11 43.1 1.4 0.025 14.1 0.0 5.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOO25164.1 - 2.3e-10 40.1 21.2 0.34 11.6 0.8 6.9 3 3 3 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.1 KOO25164.1 - 3e-10 40.2 14.9 0.0026 18.0 0.0 3.8 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO25164.1 - 4.6e-09 35.7 9.7 0.013 15.5 0.1 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO25164.1 - 4.8e-08 32.3 12.3 0.24 11.4 0.0 6.2 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO25164.1 - 4.4e-07 29.2 6.7 0.071 12.9 0.1 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.1 KOO25164.1 - 2.2e-05 24.2 19.3 0.23 11.4 0.0 6.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOO25164.1 - 4.7e-05 23.5 8.3 1.8 9.2 0.0 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO25164.1 - 0.0026 17.3 3.0 5.1 7.1 0.0 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat Sel1 PF08238.7 KOO25164.1 - 0.014 15.9 0.2 0.23 12.1 0.0 3.0 3 0 0 3 3 2 0 Sel1 repeat TPR_4 PF07721.9 KOO25164.1 - 0.036 14.5 24.2 0.14 12.6 1.5 7.3 6 1 0 6 6 6 0 Tetratricopeptide repeat Strep_pep PF14404.1 KOO25164.1 - 0.04 14.1 0.0 0.16 12.2 0.0 2.0 1 0 0 1 1 1 0 Ribosomally synthesized peptide in Streptomyces species DUF3366 PF11846.3 KOO25164.1 - 0.074 12.9 0.1 0.074 12.9 0.1 3.6 4 1 0 4 4 2 0 Domain of unknown function (DUF3366) PPR_3 PF13812.1 KOO25164.1 - 0.26 11.6 6.0 21 5.7 0.1 4.5 4 0 0 4 4 4 0 Pentatricopeptide repeat domain DUF432 PF04254.8 KOO25165.1 - 0.15 11.9 0.0 0.2 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF432) AP2 PF00847.15 KOO25166.1 - 0.00024 21.1 0.1 0.00024 21.1 0.0 2.8 3 0 0 3 3 3 1 AP2 domain Agenet PF05641.7 KOO25166.1 - 0.00098 19.2 1.1 0.67 10.1 0.1 3.4 3 0 0 3 3 3 2 Agenet domain DnaJ PF00226.26 KOO25167.1 - 3.7e-08 32.9 0.1 8.9e-08 31.7 0.1 1.6 1 0 0 1 1 1 1 DnaJ domain DUF3435 PF11917.3 KOO25167.1 - 0.87 8.2 5.3 1.1 7.8 3.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3435) MFS_1 PF07690.11 KOO25168.1 - 2.6e-17 62.6 28.7 8.6e-09 34.5 7.5 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KOO25168.1 - 0.75 8.1 15.2 0.19 10.0 0.1 2.6 3 0 0 3 3 3 0 MFS/sugar transport protein Sugar_tr PF00083.19 KOO25168.1 - 1.2 7.6 13.4 0.85 8.1 2.8 2.3 2 0 0 2 2 2 0 Sugar (and other) transporter Zip PF02535.17 KOO25169.1 - 0.6 9.0 1.6 0.82 8.6 1.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Spore_permease PF03845.8 KOO25170.1 - 8.2e-05 21.4 1.5 0.00016 20.4 1.0 1.4 1 0 0 1 1 1 1 Spore germination protein Sex_peptide PF08138.6 KOO25171.1 - 0.15 11.9 0.3 0.42 10.4 0.1 1.8 2 0 0 2 2 2 0 Sex peptide (SP) family WD40 PF00400.27 KOO25172.1 - 1.4e-91 297.4 32.6 6.9e-13 47.9 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat PD40 PF07676.7 KOO25172.1 - 3.8e-14 51.9 8.4 0.29 10.8 0.0 7.0 7 0 0 7 7 7 5 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOO25172.1 - 2.9e-11 43.4 3.5 0.0027 17.4 0.1 3.4 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.1 KOO25172.1 - 9.6e-11 41.4 1.1 4.2 7.1 0.0 6.7 1 1 6 7 7 7 2 Ciliary BBSome complex subunit 2, middle region DUF3312 PF11768.3 KOO25172.1 - 2.7e-06 25.9 0.0 1.2 7.2 0.0 4.1 1 1 2 4 4 4 3 Protein of unknown function (DUF3312) Gmad1 PF10647.4 KOO25172.1 - 1.7e-05 24.3 0.6 0.21 10.9 0.0 5.4 3 2 1 5 5 5 1 Lipoprotein LpqB beta-propeller domain RED_C PF07807.6 KOO25172.1 - 0.00093 19.3 1.4 2.8 8.1 0.1 4.3 1 1 3 4 4 4 1 RED-like protein C-terminal region Dfp1_Him1_M PF08630.5 KOO25172.1 - 0.0053 16.5 11.4 13 5.6 0.0 5.8 6 1 1 7 7 7 0 Dfp1/Him1, central region DUF4467 PF14729.1 KOO25172.1 - 0.016 15.4 0.0 3.4 8.0 0.0 3.6 1 1 3 5 5 5 0 Domain of unknown function with cystatin-like fold (DUF4467) rOmpB PF12334.3 KOO25172.1 - 0.017 14.4 6.2 6 6.1 0.1 5.1 1 1 5 6 6 6 0 Rickettsia outer membrane protein B HopJ PF08888.6 KOO25172.1 - 0.091 12.7 0.0 8.6 6.4 0.0 3.2 2 1 2 4 4 4 0 HopJ type III effector protein dsrm PF00035.20 KOO25172.1 - 0.12 12.9 0.6 14 6.3 0.0 3.3 4 1 0 4 4 3 0 Double-stranded RNA binding motif SpoU_methylase PF00588.14 KOO25173.1 - 6.7e-18 64.9 0.0 3.2e-17 62.7 0.0 1.9 2 0 0 2 2 2 1 SpoU rRNA Methylase family Cytochrom_C552 PF02335.10 KOO25173.1 - 0.75 8.4 4.2 0.45 9.1 1.9 1.3 2 0 0 2 2 2 0 Cytochrome c552 EF-hand_1 PF00036.27 KOO25174.1 - 5.2e-38 125.4 2.5 8.7e-08 30.9 0.1 8.3 8 0 0 8 8 8 6 EF hand EF-hand_7 PF13499.1 KOO25174.1 - 1.2e-37 127.8 0.2 3.1e-10 40.0 0.2 4.9 5 0 0 5 5 5 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO25174.1 - 3.4e-35 116.7 10.5 2.3e-07 30.0 0.1 8.1 7 0 0 7 7 7 6 EF-hand domain Ank_2 PF12796.2 KOO25174.1 - 1.1e-34 118.6 0.0 6.6e-18 64.8 0.0 2.8 2 1 1 3 3 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO25174.1 - 8.5e-33 110.5 2.4 1.7e-07 30.6 0.0 5.8 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.1 KOO25174.1 - 6.6e-26 90.2 0.2 1.2e-09 38.3 0.0 4.4 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO25174.1 - 2.1e-23 80.0 3.0 0.00012 21.9 0.0 5.8 5 0 0 5 5 5 4 Ankyrin repeat EF-hand_5 PF13202.1 KOO25174.1 - 5e-23 79.3 11.7 7.3e-07 28.2 0.4 7.5 7 0 0 7 7 7 5 EF hand EF-hand_8 PF13833.1 KOO25174.1 - 1.3e-20 72.7 3.8 0.00065 19.2 0.0 6.3 4 2 2 6 6 6 5 EF-hand domain pair Ank_5 PF13857.1 KOO25174.1 - 2.3e-20 72.1 4.0 4.3e-06 26.7 0.1 4.8 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Caleosin PF05042.8 KOO25174.1 - 0.0011 18.5 0.0 3.8 7.0 0.0 3.5 3 0 0 3 3 3 1 Caleosin related protein SPARC_Ca_bdg PF10591.4 KOO25174.1 - 0.0013 18.7 0.0 9.4 6.3 0.0 3.5 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region Ank_2 PF12796.2 KOO25175.1 - 1.6e-57 191.7 32.0 3.6e-13 49.6 1.8 5.7 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.25 KOO25175.1 - 7.8e-46 151.6 20.0 1.2e-07 31.1 0.0 9.4 9 0 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.1 KOO25175.1 - 8.7e-35 117.9 23.0 4.7e-08 33.0 0.0 8.1 2 2 6 8 8 8 8 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO25175.1 - 7.6e-34 115.4 10.5 1.3e-07 31.9 0.1 7.9 4 1 4 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO25175.1 - 1.8e-29 98.8 13.2 0.00023 21.0 0.0 9.9 10 0 0 10 10 10 7 Ankyrin repeat DUF4231 PF14015.1 KOO25176.1 - 1.5e-05 24.9 4.8 0.01 15.8 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF4231) DENN PF02141.16 KOO25177.1 - 7.2e-19 68.2 0.6 1.3e-18 67.3 0.4 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain GRAM PF02893.15 KOO25177.1 - 6.9e-05 22.2 0.0 0.00013 21.4 0.0 1.4 1 0 0 1 1 1 1 GRAM domain DUF705 PF05152.7 KOO25177.1 - 0.0068 15.4 0.0 0.0097 14.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF705) COG6 PF06419.6 KOO25178.1 - 2e-38 131.9 0.0 2.7e-38 131.5 0.0 1.1 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Beach PF02138.13 KOO25180.1 - 2.6e-85 286.1 0.0 3.1e-85 285.8 0.0 1.1 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.1 KOO25180.1 - 3.2e-07 30.1 0.0 1.6e-06 27.8 0.0 2.2 1 1 0 1 1 1 1 PH domain associated with Beige/BEACH Pkinase PF00069.20 KOO25182.1 - 1.8e-36 125.6 0.0 2e-36 125.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25182.1 - 3.4e-12 45.9 0.0 9.9e-12 44.4 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO25182.1 - 0.0034 17.1 0.0 0.0053 16.5 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 KOO25182.1 - 0.029 13.1 0.5 0.044 12.5 0.4 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Ank_2 PF12796.2 KOO25183.1 - 6.2e-99 324.5 64.6 1.3e-19 70.2 1.6 4.6 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank PF00023.25 KOO25183.1 - 2e-45 150.3 46.2 2.4e-06 27.0 0.2 9.4 9 1 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.1 KOO25183.1 - 3e-35 119.4 35.2 8.5e-10 38.5 0.7 7.5 1 1 7 8 8 8 8 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO25183.1 - 6.1e-32 109.4 16.8 2e-10 40.8 0.1 6.0 4 3 1 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO25183.1 - 2.9e-16 57.9 28.0 0.037 14.2 0.2 8.9 9 0 0 9 9 9 6 Ankyrin repeat PRA1 PF03208.14 KOO25184.1 - 0.014 14.7 0.5 0.014 14.7 0.3 2.2 2 0 0 2 2 2 0 PRA1 family protein PGM_PMM_I PF02878.11 KOO25184.1 - 0.022 14.2 0.1 0.067 12.6 0.0 1.8 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I Sulfotransfer_1 PF00685.22 KOO25185.1 - 9.2e-37 126.7 0.0 1.3e-36 126.2 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.1 KOO25185.1 - 0.0013 19.6 5.3 0.0013 19.6 3.7 2.0 2 1 0 2 2 2 1 Sulfotransferase family Notch PF00066.12 KOO25186.1 - 0.0094 16.1 9.4 0.021 15.0 6.5 1.6 1 0 0 1 1 1 1 LNR domain DUF1125 PF06563.6 KOO25186.1 - 0.12 12.0 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1125) Tic22 PF04278.7 KOO25187.1 - 4.2e-07 29.4 0.0 2.3e-06 27.0 0.0 1.9 1 1 0 1 1 1 1 Tic22-like family Galactosyl_T PF01762.16 KOO25188.1 - 6e-28 97.7 0.0 8.5e-28 97.2 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Ribosomal_60s PF00428.14 KOO25188.1 - 0.71 10.3 5.7 2 8.8 3.9 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein zf-RING_2 PF13639.1 KOO25189.1 - 3.5e-10 39.5 6.7 6.3e-10 38.7 4.6 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KOO25189.1 - 7.1e-08 32.4 0.7 1.2e-07 31.7 0.5 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger FANCL_C PF11793.3 KOO25189.1 - 5.6e-06 26.2 2.3 8.8e-06 25.6 1.6 1.3 1 0 0 1 1 1 1 FANCL C-terminal domain zf-C3HC4_2 PF13923.1 KOO25189.1 - 0.00021 21.2 8.2 0.0043 17.0 5.7 2.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 KOO25189.1 - 0.0016 18.2 1.7 0.0029 17.4 1.2 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.1 KOO25189.1 - 0.0023 17.5 5.5 0.0052 16.4 3.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO25189.1 - 0.013 15.1 6.9 0.028 14.1 4.8 1.6 1 0 0 1 1 1 0 zinc-RING finger domain RINGv PF12906.2 KOO25189.1 - 0.015 15.3 6.8 0.025 14.5 3.9 2.1 2 1 0 2 2 2 0 RING-variant domain zf-C3HC4 PF00097.20 KOO25189.1 - 0.35 10.5 6.2 2.2 8.0 4.3 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Glyco_transf_90 PF05686.7 KOO25190.1 - 2.6e-23 82.3 0.1 1.2e-22 80.1 0.1 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 90 DUF2309 PF10070.4 KOO25191.1 - 0.037 12.1 0.0 0.047 11.8 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2309) ShK PF01549.19 KOO25192.1 - 4.3e-46 154.9 80.8 1.7e-09 37.8 5.4 6.1 6 0 0 6 6 6 6 ShK domain-like zf-CCCH PF00642.19 KOO25192.1 - 1.5e-05 24.5 0.6 1.9 8.2 0.0 4.5 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Hist_deacetyl PF00850.14 KOO25193.1 - 1.8e-28 99.7 0.7 5.3e-28 98.2 0.5 1.6 1 1 0 1 1 1 1 Histone deacetylase domain DUF2407_C PF13373.1 KOO25194.1 - 0.067 13.1 0.1 5.1 7.0 0.0 2.3 2 0 0 2 2 2 0 DUF2407 C-terminal domain Macoilin PF09726.4 KOO25195.1 - 0.0034 15.7 0.7 0.0038 15.6 0.5 1.0 1 0 0 1 1 1 1 Transmembrane protein Cortex-I_coil PF09304.5 KOO25195.1 - 0.034 14.1 0.8 0.045 13.7 0.5 1.2 1 0 0 1 1 1 0 Cortexillin I, coiled coil CppA_N PF14506.1 KOO25195.1 - 0.088 12.4 0.1 0.11 12.1 0.1 1.0 1 0 0 1 1 1 0 CppA N-terminal DUF296 PF03479.10 KOO25196.1 - 8.1e-26 89.9 1.8 1.1e-25 89.5 1.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF296) DUF1632 PF07857.7 KOO25197.1 - 2.1e-53 181.2 14.0 2.9e-47 161.0 0.9 3.2 3 0 0 3 3 3 2 CEO family (DUF1632) Sugar_transport PF06800.7 KOO25197.1 - 1.7e-09 37.1 16.3 1.2e-08 34.4 6.4 2.9 2 1 0 2 2 2 2 Sugar transport protein Pescadillo_N PF06732.6 KOO25198.1 - 8.1e-102 340.2 1.0 1.1e-101 339.8 0.7 1.1 1 0 0 1 1 1 1 Pescadillo N-terminus BRCT PF00533.21 KOO25198.1 - 4.2e-09 36.4 0.0 9e-09 35.3 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Sugar_tr PF00083.19 KOO25201.1 - 1.5e-87 294.0 14.0 4.7e-87 292.4 9.7 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOO25201.1 - 1.1e-19 70.4 31.1 7.4e-19 67.6 18.4 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KOO25201.1 - 0.0014 17.1 1.1 0.0014 17.1 0.8 2.8 2 1 0 2 2 2 1 MFS/sugar transport protein EF-hand_6 PF13405.1 KOO25202.1 - 3.6e-06 26.4 0.4 0.13 12.2 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO25202.1 - 1.8e-05 24.7 0.2 5.5e-05 23.2 0.2 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO25202.1 - 4.6e-05 22.4 0.1 0.0006 18.9 0.1 2.4 2 0 0 2 2 2 1 EF hand EF-hand_10 PF14788.1 KOO25202.1 - 0.0017 17.9 0.1 0.0035 16.9 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 KOO25202.1 - 0.032 13.8 0.5 0.071 12.7 0.3 1.6 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.1 KOO25202.1 - 0.06 12.7 0.2 0.12 11.7 0.2 1.5 1 0 0 1 1 1 0 EF hand WD40 PF00400.27 KOO25205.1 - 6.7e-76 247.7 20.1 3.5e-14 52.0 0.4 7.5 7 1 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 KOO25205.1 - 1.4e-13 49.8 13.6 0.015 13.4 0.0 5.9 2 1 4 6 6 6 5 Nucleoporin Nup120/160 eIF2A PF08662.6 KOO25205.1 - 3.8e-09 36.5 0.0 0.00016 21.4 0.0 3.4 1 1 3 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.6 KOO25205.1 - 0.00011 21.1 0.6 0.37 9.4 0.0 3.8 1 1 3 4 4 4 2 Nup133 N terminal like Cytochrom_D1 PF02239.11 KOO25205.1 - 0.0002 19.8 0.0 0.057 11.7 0.0 2.8 2 1 0 2 2 2 2 Cytochrome D1 heme domain PQQ_2 PF13360.1 KOO25205.1 - 0.0089 15.5 0.5 6.8 6.0 0.0 3.0 2 1 0 2 2 2 1 PQQ-like domain Nbas_N PF15492.1 KOO25205.1 - 0.022 13.8 0.2 0.39 9.7 0.0 2.8 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal DPPIV_N PF00930.16 KOO25205.1 - 0.045 12.3 0.0 0.28 9.7 0.0 2.2 3 0 0 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region VID27 PF08553.5 KOO25205.1 - 0.071 11.3 0.2 10 4.1 0.0 3.0 2 1 1 3 3 3 0 VID27 cytoplasmic protein DUF3312 PF11768.3 KOO25205.1 - 0.084 11.0 0.0 2.1 6.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3312) PQQ_3 PF13570.1 KOO25205.1 - 0.11 12.8 0.7 37 4.7 0.0 3.3 2 1 0 2 2 2 0 PQQ-like domain Pkinase PF00069.20 KOO25207.1 - 2.4e-11 43.2 0.0 2.7e-11 43.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25207.1 - 9.7e-08 31.3 0.0 1.1e-07 31.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase TAT_signal PF10518.4 KOO25208.1 - 0.12 12.4 5.6 0.31 11.1 3.9 1.7 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence PX PF00787.19 KOO25209.1 - 5e-12 45.6 0.0 7.8e-12 44.9 0.0 1.2 1 0 0 1 1 1 1 PX domain VPS9 PF02204.13 KOO25209.1 - 2.1e-10 40.5 0.0 4.2e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain ART PF01129.13 KOO25210.1 - 0.00015 20.9 0.0 0.00034 19.8 0.0 1.5 1 1 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.9 KOO25210.1 - 0.00052 19.2 0.0 0.25 10.5 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosyltransferase exoenzyme Ribosomal_S8e PF01201.17 KOO25213.1 - 7.6e-40 136.1 0.9 3.5e-31 108.0 0.0 2.2 1 1 1 2 2 2 2 Ribosomal protein S8e Enkurin PF13864.1 KOO25213.1 - 0.021 15.0 0.1 0.021 15.0 0.1 2.1 2 1 0 2 2 2 0 Calmodulin-binding PRONE PF03759.8 KOO25213.1 - 0.068 11.7 2.2 0.085 11.3 1.2 1.3 1 1 0 1 1 1 0 PRONE (Plant-specific Rop nucleotide exchanger) Mer2 PF09074.5 KOO25213.1 - 0.19 11.6 4.9 0.85 9.5 3.4 1.9 1 1 0 1 1 1 0 Mer2 RWD PF05773.17 KOO25214.1 - 0.00011 22.0 0.0 0.00026 20.8 0.0 1.7 1 1 0 1 1 1 1 RWD domain DUF2288 PF10052.4 KOO25214.1 - 0.049 13.3 0.7 5.8 6.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2288) FH2 PF02181.18 KOO25214.1 - 0.079 11.8 0.2 0.11 11.3 0.1 1.1 1 0 0 1 1 1 0 Formin Homology 2 Domain DUF3753 PF12575.3 KOO25214.1 - 0.19 11.5 1.3 0.33 10.7 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3753) DLD PF14878.1 KOO25214.1 - 0.26 11.3 3.9 0.51 10.4 2.7 1.4 1 0 0 1 1 1 0 Death-like domain of SPT6 GLTSCR1 PF15249.1 KOO25214.1 - 0.47 10.5 3.8 0.73 9.9 2.6 1.3 1 0 0 1 1 1 0 Glioma tumor suppressor candidate region Alpha_kinase PF02816.13 KOO25215.1 - 1.1e-10 41.4 0.0 1.6e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Alpha-kinase family PHD PF00628.24 KOO25216.1 - 0.0022 17.6 8.4 0.0022 17.6 5.9 2.1 2 0 0 2 2 2 1 PHD-finger zf-PHD-like PF15446.1 KOO25216.1 - 0.0056 15.9 2.1 0.013 14.8 1.4 1.5 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain IL6Ra-bind PF09240.5 KOO25216.1 - 0.025 14.7 0.6 0.048 13.8 0.4 1.4 1 0 0 1 1 1 0 Interleukin-6 receptor alpha chain, binding zf-RING_6 PF14835.1 KOO25216.1 - 0.26 11.0 5.1 0.63 9.8 3.5 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein HA2 PF04408.18 KOO25217.1 - 1.7e-18 66.4 0.0 4.7e-18 65.0 0.0 1.7 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 KOO25217.1 - 7.1e-17 61.2 0.0 1.2e-16 60.5 0.0 1.3 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold CaMKII_AD PF08332.5 KOO25218.1 - 1.9e-18 66.5 0.0 2.6e-18 66.1 0.0 1.2 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II Association DUF4440 PF14534.1 KOO25218.1 - 5.7e-12 45.7 0.0 8e-12 45.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_3 PF13474.1 KOO25218.1 - 4.1e-08 33.2 0.0 5.7e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_2 PF12680.2 KOO25218.1 - 1e-06 29.0 0.0 1.5e-06 28.5 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF3225 PF11533.3 KOO25218.1 - 0.013 15.1 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3225) Amino_oxidase PF01593.19 KOO25220.1 - 9.3e-22 77.7 0.5 1.3e-21 77.2 0.3 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase COPI_C PF06957.6 KOO25221.1 - 0.077 11.5 2.6 0.14 10.6 1.8 1.3 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus PH_8 PF15409.1 KOO25222.1 - 0.00022 21.2 0.3 0.00062 19.7 0.2 1.8 2 1 0 2 2 2 1 Pleckstrin homology domain PH PF00169.24 KOO25222.1 - 0.0017 18.5 0.3 0.63 10.2 0.3 2.3 1 1 1 2 2 2 2 PH domain PAP1 PF08601.5 KOO25222.1 - 0.61 9.7 4.8 0.1 12.2 0.2 1.9 2 0 0 2 2 2 0 Transcription factor PAP1 MMgT PF10270.4 KOO25223.1 - 2.8e-08 34.1 0.1 7.5e-08 32.7 0.0 1.7 2 0 0 2 2 2 1 Membrane magnesium transporter COX6A PF02046.10 KOO25223.1 - 5.7e-07 29.4 0.0 8e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa TMEM210 PF15195.1 KOO25223.1 - 0.029 14.4 0.1 0.056 13.5 0.0 1.4 2 0 0 2 2 2 0 TMEM210 family MscS_porin PF12795.2 KOO25224.1 - 0.00034 20.0 2.4 0.00044 19.6 1.6 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain ERM PF00769.14 KOO25224.1 - 0.13 11.7 4.8 0.16 11.4 3.3 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family CCDC155 PF14662.1 KOO25224.1 - 0.16 11.5 3.3 0.7 9.4 2.4 1.9 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 TPR_MLP1_2 PF07926.7 KOO25224.1 - 1.3 8.7 4.7 1.9 8.2 2.0 2.2 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein OB_NTP_bind PF07717.11 KOO25225.1 - 1e-18 67.2 0.0 2.5e-18 65.9 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 KOO25225.1 - 1.4e-13 50.7 0.0 3.5e-13 49.4 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 KOO25225.1 - 4.2e-13 48.9 0.3 1.4e-12 47.2 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOO25225.1 - 5e-10 39.1 0.3 9.1e-10 38.2 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 KOO25225.1 - 4.3e-06 26.9 0.1 1.6e-05 25.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KOO25225.1 - 0.0017 18.3 10.0 0.073 13.0 1.4 4.5 3 2 0 4 4 4 1 AAA ATPase domain AAA_30 PF13604.1 KOO25225.1 - 0.0028 17.2 0.5 0.0028 17.2 0.3 2.0 3 0 0 3 3 3 1 AAA domain ABC_tran PF00005.22 KOO25225.1 - 0.017 15.4 0.0 0.042 14.1 0.0 1.6 1 0 0 1 1 1 0 ABC transporter FtsK_SpoIIIE PF01580.13 KOO25225.1 - 0.032 13.7 0.4 0.089 12.2 0.0 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_29 PF13555.1 KOO25225.1 - 0.043 13.3 0.0 0.11 12.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_10 PF12846.2 KOO25225.1 - 0.098 12.0 0.1 0.63 9.4 0.0 2.3 3 0 0 3 3 3 0 AAA-like domain KaiC PF06745.8 KOO25225.1 - 0.15 11.1 0.0 0.32 10.0 0.0 1.5 1 0 0 1 1 1 0 KaiC Dynamin_N PF00350.18 KOO25225.1 - 0.18 11.6 0.0 0.68 9.7 0.0 2.0 2 0 0 2 2 2 0 Dynamin family SICA_C PF12879.2 KOO25226.1 - 0.018 14.9 1.8 0.022 14.6 1.3 1.2 1 0 0 1 1 1 0 SICA C-terminal inner membrane domain TEX19 PF15553.1 KOO25226.1 - 0.53 10.1 3.0 2.9 7.7 2.1 1.9 1 1 0 1 1 1 0 Testis-expressed protein 19 Myosin_head PF00063.16 KOO25227.1 - 4.5e-173 576.9 0.0 8.7e-150 499.9 0.0 2.0 2 0 0 2 2 2 2 Myosin head (motor domain) BTB_2 PF02214.17 KOO25227.1 - 1.6e-06 28.1 0.0 2.7e-05 24.2 0.0 2.4 1 1 0 1 1 1 1 BTB/POZ domain Myosin_N PF02736.14 KOO25227.1 - 0.00012 21.7 1.9 0.00022 20.8 1.3 1.4 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_22 PF13401.1 KOO25227.1 - 0.0089 16.1 0.0 0.027 14.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain CAP_N PF01213.14 KOO25227.1 - 4.6 6.4 6.0 10 5.3 4.2 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Rad9 PF04139.8 KOO25228.1 - 1.1e-48 165.5 0.0 1.3e-48 165.3 0.0 1.0 1 0 0 1 1 1 1 Rad9 PCNA_N PF00705.13 KOO25228.1 - 0.023 14.2 0.0 0.039 13.4 0.0 1.4 1 0 0 1 1 1 0 Proliferating cell nuclear antigen, N-terminal domain DUF605 PF04652.11 KOO25228.1 - 0.051 12.9 6.5 0.07 12.5 4.5 1.2 1 0 0 1 1 1 0 Vta1 like TFIIH_BTF_p62_N PF08567.6 KOO25228.1 - 0.13 11.9 0.0 0.3 10.7 0.0 1.6 1 0 0 1 1 1 0 TFIIH p62 subunit, N-terminal domain PAT1 PF09770.4 KOO25228.1 - 4.8 5.3 6.4 6.2 4.9 4.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DXP_reductoisom PF02670.11 KOO25229.1 - 1.3e-41 142.1 0.3 2.3e-41 141.3 0.2 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase DXPR_C PF13288.1 KOO25229.1 - 3.4e-37 127.1 0.0 6.8e-37 126.1 0.0 1.5 1 0 0 1 1 1 1 DXP reductoisomerase C-terminal domain DXP_redisom_C PF08436.7 KOO25229.1 - 4.4e-33 113.0 0.0 8.8e-33 112.0 0.0 1.5 1 0 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal HMG_box PF00505.14 KOO25231.1 - 1.1e-10 41.6 0.0 2e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box SAP PF02037.22 KOO25231.1 - 2e-08 33.4 0.7 3.8e-08 32.6 0.5 1.4 1 0 0 1 1 1 1 SAP domain Toprim_C_rpt PF13368.1 KOO25231.1 - 4.9e-07 30.1 16.9 2.3e-06 27.9 0.1 6.1 3 1 2 5 5 5 1 Topoisomerase C-terminal repeat zf-C4_Topoisom PF01396.14 KOO25231.1 - 1.7e-06 27.4 0.3 2.9e-06 26.6 0.2 1.4 1 0 0 1 1 1 1 Topoisomerase DNA binding C4 zinc finger HMG_box_2 PF09011.5 KOO25231.1 - 1e-05 25.7 0.0 1e-05 25.7 0.0 1.7 2 0 0 2 2 2 1 HMG-box domain EF-hand_7 PF13499.1 KOO25233.1 - 1.7e-25 88.8 3.2 1.1e-12 47.9 0.0 3.3 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO25233.1 - 1.9e-24 83.0 5.4 2.9e-05 23.0 0.0 4.8 5 0 0 5 5 5 4 EF hand EF-hand_5 PF13202.1 KOO25233.1 - 3.1e-20 70.5 8.1 0.00018 20.6 0.1 5.2 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.1 KOO25233.1 - 2.9e-19 67.1 8.2 0.0011 18.6 0.2 4.8 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.1 KOO25233.1 - 4.4e-19 67.8 0.7 0.00016 21.2 0.0 5.1 4 1 1 5 5 5 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO25233.1 - 5.5e-06 26.3 0.5 0.031 14.3 0.1 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO25233.1 - 0.0099 15.5 0.8 12 5.6 0.0 3.3 3 1 1 4 4 4 2 Cytoskeletal-regulatory complex EF hand DUF2693 PF10902.3 KOO25233.1 - 0.11 12.4 0.1 4.8 7.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2693) Peptidase_C48 PF02902.14 KOO25234.1 - 2.1e-29 102.7 0.0 4.5e-29 101.6 0.0 1.6 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain SAM_2 PF07647.12 KOO25234.1 - 3.7e-13 49.1 0.1 6.7e-13 48.2 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 KOO25234.1 - 4.6e-13 49.1 0.1 1.1e-12 47.8 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) IGR PF09597.5 KOO25234.1 - 0.12 12.2 0.0 0.28 11.1 0.0 1.7 1 0 0 1 1 1 0 IGR protein motif Sel1 PF08238.7 KOO25235.1 - 1.6e-14 53.9 42.3 8.7e-06 26.2 0.0 8.5 9 0 0 9 9 9 4 Sel1 repeat Glutaredoxin PF00462.19 KOO25235.1 - 0.11 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin LSM PF01423.17 KOO25236.1 - 2.4e-12 46.2 0.4 3.7e-12 45.6 0.3 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 KOO25236.1 - 0.00021 21.1 0.1 0.00031 20.6 0.1 1.3 1 1 0 1 1 1 1 Ataxin 2 SM domain DUF2642 PF10842.3 KOO25236.1 - 0.024 14.0 0.0 0.05 13.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2642) Exostosin PF03016.10 KOO25237.1 - 2.1e-14 53.2 0.0 1.7e-12 47.0 0.0 2.3 2 0 0 2 2 2 2 Exostosin family Galactosyl_T PF01762.16 KOO25237.1 - 2.2e-10 40.4 0.0 4.3e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.11 KOO25237.1 - 0.33 10.1 0.0 0.58 9.3 0.0 1.3 1 0 0 1 1 1 0 Fringe-like SHIPPO-rpt PF07004.7 KOO25238.1 - 0.035 15.0 4.0 0.035 15.0 2.8 2.9 3 1 0 3 3 3 0 Sperm-tail PG-rich repeat Phytochelatin PF05023.9 KOO25239.1 - 4.2e-30 104.3 0.0 6.9e-30 103.6 0.0 1.3 1 0 0 1 1 1 1 Phytochelatin synthase PseudoU_synth_2 PF00849.17 KOO25239.1 - 0.0026 17.5 0.0 0.0039 17.0 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase Peptidase_C39_2 PF13529.1 KOO25239.1 - 0.041 14.2 0.1 0.26 11.6 0.0 2.0 2 0 0 2 2 2 0 Peptidase_C39 like family CmcI PF04989.7 KOO25240.1 - 1.2e-32 112.9 0.0 2.1e-15 56.6 0.0 2.3 2 0 0 2 2 2 2 Cephalosporin hydroxylase Methyltransf_24 PF13578.1 KOO25240.1 - 0.00024 21.9 0.0 0.00046 20.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain 6PF2K PF01591.13 KOO25241.1 - 4.5e-55 186.1 0.0 6.7e-55 185.5 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 KOO25241.1 - 1e-08 35.4 0.2 3.5e-06 27.2 0.0 2.7 3 0 0 3 3 3 2 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 KOO25241.1 - 4.4e-05 23.3 0.1 0.00011 22.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain PDZ PF00595.19 KOO25241.1 - 0.0039 17.3 0.0 0.0077 16.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) AAA_17 PF13207.1 KOO25241.1 - 0.014 16.2 0.0 0.049 14.4 0.0 2.1 1 1 0 1 1 1 0 AAA domain cobW PF02492.14 KOO25242.1 - 1.6e-49 167.7 0.5 2.2e-49 167.2 0.3 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 KOO25242.1 - 2.7e-18 65.4 0.3 2.8e-17 62.1 0.2 2.5 1 1 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain Arch_ATPase PF01637.13 KOO25242.1 - 0.0023 17.6 0.0 0.0038 16.9 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase ArgK PF03308.11 KOO25242.1 - 0.023 13.4 0.2 0.85 8.3 0.1 2.2 2 0 0 2 2 2 0 ArgK protein AAA_10 PF12846.2 KOO25242.1 - 0.036 13.5 0.0 0.065 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain UPF0079 PF02367.12 KOO25242.1 - 0.056 13.0 0.1 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_28 PF13521.1 KOO25242.1 - 0.059 13.3 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 KOO25242.1 - 0.077 13.1 0.0 0.15 12.2 0.0 1.5 1 1 0 1 1 1 0 AAA domain MobB PF03205.9 KOO25242.1 - 0.089 12.4 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Pkinase_Tyr PF07714.12 KOO25243.1 - 2.2e-50 171.1 0.0 2.8e-50 170.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 KOO25243.1 - 2.7e-46 157.8 0.0 3.6e-46 157.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain PX PF00787.19 KOO25243.1 - 7.2e-06 25.7 0.0 1.2e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 PX domain APH PF01636.18 KOO25243.1 - 0.095 12.4 4.3 0.34 10.6 0.0 3.1 3 1 1 4 4 4 0 Phosphotransferase enzyme family RdRP PF05183.7 KOO25244.1 - 6.4e-59 200.1 0.0 9.1e-59 199.6 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Ank_2 PF12796.2 KOO25245.1 - 1.3e-23 83.1 0.7 9.9e-14 51.4 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) EF-hand_7 PF13499.1 KOO25245.1 - 2.2e-20 72.5 0.3 9.6e-07 28.8 0.0 4.8 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.27 KOO25245.1 - 2.9e-16 57.4 5.9 0.00037 19.5 0.0 5.7 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.1 KOO25245.1 - 2.3e-15 54.9 1.5 0.0016 18.1 0.0 6.2 6 0 0 6 6 6 2 EF-hand domain EF-hand_5 PF13202.1 KOO25245.1 - 2.3e-13 48.8 2.2 0.0029 16.8 0.0 5.5 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.1 KOO25245.1 - 3.8e-12 45.6 4.6 0.014 14.9 0.0 5.8 3 3 3 6 6 6 3 EF-hand domain pair Ank PF00023.25 KOO25245.1 - 4.5e-12 45.1 0.4 0.016 15.0 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeat SPARC_Ca_bdg PF10591.4 KOO25245.1 - 4.4e-09 36.3 1.8 0.091 12.8 0.0 3.9 3 0 0 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region Ank_5 PF13857.1 KOO25245.1 - 1.4e-07 31.4 0.2 0.034 14.4 0.0 3.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO25245.1 - 4.7e-07 30.1 0.5 4e-05 23.9 0.1 2.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO25245.1 - 1.3e-06 28.0 0.2 1.2 9.5 0.0 4.1 3 0 0 3 3 3 2 Ankyrin repeat EF-hand_10 PF14788.1 KOO25245.1 - 0.00045 19.8 4.2 2.9 7.6 0.0 4.7 5 0 0 5 5 5 1 EF hand EF-hand_9 PF14658.1 KOO25245.1 - 0.0021 17.9 0.1 26 4.8 0.0 3.5 3 0 0 3 3 3 0 EF-hand domain Phage_B PF02304.10 KOO25245.1 - 0.15 12.3 2.3 2.4 8.4 0.2 3.7 3 1 0 3 3 3 0 Scaffold protein B EF-hand_4 PF12763.2 KOO25245.1 - 0.16 11.7 0.2 62 3.3 0.0 3.8 3 2 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand ORC2 PF04084.9 KOO25246.1 - 1e-32 113.2 0.0 1.2e-32 113.0 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 DUF1664 PF07889.7 KOO25247.1 - 0.058 13.2 0.3 0.097 12.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Sre PF03125.13 KOO25247.1 - 0.1 11.5 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 C. elegans Sre G protein-coupled chemoreceptor DUF3461 PF11944.3 KOO25247.1 - 0.14 12.0 0.1 0.23 11.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3461) Cortex-I_coil PF09304.5 KOO25247.1 - 0.18 11.8 4.8 0.073 13.1 1.0 2.0 2 0 0 2 2 2 0 Cortexillin I, coiled coil DUF4349 PF14257.1 KOO25247.1 - 0.79 8.9 5.4 1.7 7.8 3.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) Cep57_CLD_2 PF14197.1 KOO25247.1 - 3.2 7.7 10.5 9.5 6.2 3.2 2.8 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Utp11 PF03998.8 KOO25248.1 - 9.1e-61 205.7 12.5 1.6e-60 204.9 8.6 1.4 1 1 0 1 1 1 1 Utp11 protein DHBP_synthase PF00926.14 KOO25248.1 - 0.045 12.9 0.1 0.072 12.3 0.0 1.2 1 0 0 1 1 1 0 3,4-dihydroxy-2-butanone 4-phosphate synthase Apc13p PF05839.6 KOO25249.1 - 0.0015 18.4 3.7 0.026 14.4 2.5 2.0 1 1 0 1 1 1 1 Apc13p protein SIP1 PF04938.7 KOO25249.1 - 0.026 13.9 0.0 0.03 13.6 0.0 1.1 1 0 0 1 1 1 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) DUF4193 PF13834.1 KOO25249.1 - 0.035 14.2 0.1 0.04 14.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4193) HSP70 PF00012.15 KOO25250.1 - 4.1e-102 342.0 0.1 5.6e-102 341.6 0.1 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KOO25250.1 - 3.7e-13 48.7 5.5 9.6e-09 34.2 0.5 3.0 3 0 0 3 3 3 2 MreB/Mbl protein FtsA PF14450.1 KOO25250.1 - 5.4e-07 29.4 4.0 0.055 13.3 0.0 4.0 4 0 0 4 4 4 2 Cell division protein FtsA DDR PF08841.5 KOO25250.1 - 0.004 16.0 2.2 0.02 13.7 0.3 2.4 3 0 0 3 3 3 1 Diol dehydratase reactivase ATPase-like domain FGGY_C PF02782.11 KOO25250.1 - 0.032 13.8 0.1 0.054 13.1 0.1 1.3 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain StbA PF06406.6 KOO25250.1 - 0.054 12.4 0.0 0.1 11.5 0.0 1.4 1 0 0 1 1 1 0 StbA protein TPP_enzyme_N PF02776.13 KOO25250.1 - 0.11 11.9 2.6 0.15 11.5 0.7 2.0 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Aminotran_3 PF00202.16 KOO25251.1 - 9.1e-62 208.8 0.1 1.3e-61 208.3 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class-III DUF228 PF02989.9 KOO25251.1 - 0.093 12.2 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 Lyme disease proteins of unknown function Amino_oxidase PF01593.19 KOO25253.1 - 1.1e-29 103.8 0.0 2.8e-29 102.4 0.0 1.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 KOO25253.1 - 6.3e-13 48.5 0.1 1.4e-12 47.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOO25253.1 - 1.9e-06 27.0 0.1 3.8e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.2 KOO25253.1 - 0.00043 19.4 0.2 0.00067 18.8 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 KOO25253.1 - 0.00054 18.9 0.0 0.0011 17.9 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.14 KOO25253.1 - 0.001 18.2 0.3 0.0014 17.7 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.7 KOO25253.1 - 0.0088 15.0 0.1 0.015 14.2 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein ApbA PF02558.11 KOO25253.1 - 0.0091 15.4 0.0 0.016 14.6 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.22 KOO25253.1 - 0.016 15.5 0.1 0.034 14.5 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 KOO25253.1 - 0.022 13.6 0.0 0.03 13.1 0.0 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox_3 PF13738.1 KOO25253.1 - 0.026 14.6 0.1 0.047 13.7 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 KOO25253.1 - 0.033 13.2 0.2 0.059 12.4 0.1 1.3 1 0 0 1 1 1 0 Thi4 family ThiF PF00899.16 KOO25253.1 - 0.057 13.2 0.3 0.095 12.5 0.2 1.3 1 0 0 1 1 1 0 ThiF family 3HCDH_N PF02737.13 KOO25253.1 - 0.17 11.5 0.0 0.26 10.9 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1736 PF08409.6 KOO25254.1 - 0.00033 20.1 0.5 0.0016 18.0 0.3 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1736) DnaJ PF00226.26 KOO25254.1 - 0.00043 19.9 0.0 0.00077 19.1 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain LRR_6 PF13516.1 KOO25255.1 - 7.1e-22 74.9 27.8 0.05 13.6 0.4 13.5 14 0 0 14 14 14 7 Leucine Rich repeat LRR_4 PF12799.2 KOO25255.1 - 1e-08 34.6 28.5 0.012 15.1 0.3 9.1 5 2 6 12 12 12 6 Leucine Rich repeats (2 copies) IQ PF00612.22 KOO25255.1 - 3.1e-07 29.4 37.9 0.058 13.0 0.7 6.0 5 0 0 5 5 5 5 IQ calmodulin-binding motif LRR_8 PF13855.1 KOO25255.1 - 0.0019 17.9 0.1 0.0019 17.9 0.1 6.7 6 2 2 8 8 8 2 Leucine rich repeat LRR_1 PF00560.28 KOO25255.1 - 0.013 15.3 24.5 5 7.5 0.0 10.8 12 1 1 13 13 13 0 Leucine Rich Repeat AAA_22 PF13401.1 KOO25255.1 - 0.017 15.2 0.8 0.16 12.0 0.0 3.1 3 0 0 3 3 3 0 AAA domain LRR_7 PF13504.1 KOO25255.1 - 0.91 9.9 21.8 33 5.2 0.0 9.9 12 0 0 12 12 12 0 Leucine rich repeat Glyco_transf_90 PF05686.7 KOO25256.1 - 1e-38 133.1 0.0 1e-36 126.4 0.0 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.1 KOO25256.1 - 0.00026 21.1 0.0 0.00049 20.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 GRAM PF02893.15 KOO25256.1 - 0.063 12.8 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 GRAM domain DUF4511 PF14974.1 KOO25257.1 - 0.0006 19.5 0.0 0.0011 18.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4511) VWA_CoxE PF05762.9 KOO25257.1 - 0.012 14.8 1.3 0.016 14.3 0.1 1.7 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein WW PF00397.21 KOO25258.1 - 4.1e-08 32.9 4.4 9.3e-08 31.7 3.0 1.7 1 0 0 1 1 1 1 WW domain TIR_2 PF13676.1 KOO25258.1 - 2.6e-06 27.5 0.0 8.5e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 TIR domain MerR_1 PF13411.1 KOO25258.1 - 5.6e-05 22.8 0.0 32 4.3 0.0 8.4 9 4 3 13 13 13 0 MerR HTH family regulatory protein Ribosomal_L13e PF01294.13 KOO25258.1 - 8e-05 22.1 14.7 1.8 7.9 0.2 7.9 4 3 5 9 9 9 2 Ribosomal protein L13e RPAP1_C PF08620.5 KOO25258.1 - 0.013 15.3 1.0 35 4.3 0.0 5.9 5 1 0 5 5 5 0 RPAP1-like, C-terminal DUF2774 PF11242.3 KOO25258.1 - 2 8.4 4.1 74 3.4 0.0 4.3 5 0 0 5 5 5 0 Protein of unknown function (DUF2774) SinI PF08671.5 KOO25258.1 - 3.6 7.1 23.1 32 4.0 0.0 10.8 13 3 3 17 17 17 0 Anti-repressor SinI DUF780 PF05611.6 KOO25258.1 - 4.9 7.9 8.4 9.2 7.0 0.4 4.9 4 1 1 5 5 5 0 Caenorhabditis elegans protein of unknown function (DUF780) MOSC_N PF03476.11 KOO25258.1 - 5.4 6.7 10.8 18 5.0 0.5 5.2 2 1 3 5 5 5 0 MOSC N-terminal beta barrel domain Tom37_C PF11801.3 KOO25259.1 - 3.8e-10 39.8 0.1 2.8e-06 27.3 0.0 3.0 2 1 1 3 3 3 2 Tom37 C-terminal domain GST_C_2 PF13410.1 KOO25259.1 - 4.3e-05 23.3 0.3 9.5e-05 22.2 0.2 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 KOO25259.1 - 4.7e-05 23.7 0.0 0.0001 22.7 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Spt5-NGN PF03439.8 KOO25260.1 - 5.9e-18 64.4 0.1 1.2e-17 63.4 0.0 1.6 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section DUF1287 PF06940.6 KOO25260.1 - 0.0083 15.5 0.0 0.029 13.7 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1287) KOW PF00467.24 KOO25260.1 - 0.15 11.8 0.2 0.15 11.8 0.2 5.4 7 0 0 7 7 7 0 KOW motif DUF1726 PF08351.6 KOO25261.1 - 5.9e-39 131.6 0.0 1.4e-38 130.5 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) Helicase_RecD PF05127.9 KOO25261.1 - 2.8e-32 111.7 0.0 9.3e-32 110.0 0.0 1.8 2 0 0 2 2 2 1 Helicase tRNA_bind_2 PF13725.1 KOO25261.1 - 1.5e-23 82.8 0.4 1e-22 80.1 0.5 2.2 2 0 0 2 2 2 1 Possible tRNA binding domain GNAT_acetyltr_2 PF13718.1 KOO25261.1 - 3.7e-16 59.0 0.3 2.8e-15 56.1 0.2 2.2 1 1 0 1 1 1 1 GNAT acetyltransferase 2 DEAD PF00270.24 KOO25261.1 - 0.04 13.4 0.0 0.081 12.4 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase Methyltransf_10 PF05971.7 KOO25261.1 - 0.16 11.1 0.0 0.28 10.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF890) DUF1572 PF07609.6 KOO25262.1 - 0.15 11.5 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1572) UPF0220 PF05255.6 KOO25263.1 - 1.3e-22 79.7 0.7 1.8e-17 63.1 0.0 2.0 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0220) PDZ PF00595.19 KOO25266.1 - 0.00056 20.0 0.0 0.00093 19.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) polyprenyl_synt PF00348.12 KOO25267.1 - 9.2e-61 204.9 0.0 1.2e-60 204.6 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Cellulase PF00150.13 KOO25268.1 - 3.9e-32 111.5 0.0 7.8e-32 110.5 0.0 1.4 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Pro_isomerase PF00160.16 KOO25269.1 - 1.8e-28 99.6 0.0 2.7e-28 99.1 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD BPS PF08947.5 KOO25269.1 - 1.5 8.4 5.3 0.92 9.1 1.8 1.9 1 1 1 2 2 2 0 BPS (Between PH and SH2) ZZ PF00569.12 KOO25270.1 - 7.6e-05 22.1 0.0 0.00012 21.5 0.0 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type DUF2201_N PF13203.1 KOO25270.1 - 0.018 14.1 8.4 0.019 14.1 5.8 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain TATR PF03430.8 KOO25270.1 - 2.5 6.6 9.0 2.9 6.4 6.3 1.0 1 0 0 1 1 1 0 Trans-activating transcriptional regulator SpoU_methylase PF00588.14 KOO25271.1 - 4.5e-30 104.3 0.0 6.5e-30 103.8 0.0 1.2 1 0 0 1 1 1 1 SpoU rRNA Methylase family EGF_2 PF07974.8 KOO25271.1 - 0.0014 18.7 7.6 0.0014 18.7 5.3 2.5 2 0 0 2 2 2 1 EGF-like domain Na_H_Exchanger PF00999.16 KOO25274.1 - 9.3e-50 169.2 44.7 1.2e-49 168.9 31.0 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family EF-hand_5 PF13202.1 KOO25274.1 - 0.00017 20.8 0.0 0.13 11.6 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.27 KOO25274.1 - 0.00017 20.6 0.0 0.068 12.4 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO25274.1 - 0.00026 21.0 0.0 0.0086 16.1 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO25274.1 - 0.0067 16.0 0.0 1 9.0 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO25274.1 - 0.093 12.6 0.0 19 5.4 0.0 3.3 3 0 0 3 3 3 0 EF-hand domain tRNA_m1G_MT PF01746.16 KOO25275.1 - 1.6e-32 112.6 0.1 3.6e-32 111.4 0.0 1.6 2 0 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase SR-25 PF10500.4 KOO25275.1 - 1.1 8.6 15.3 2 7.8 10.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein C2 PF00168.25 KOO25276.1 - 2.2e-17 62.6 0.0 1e-13 50.9 0.0 3.2 2 1 0 2 2 2 2 C2 domain PTEN_C2 PF10409.4 KOO25276.1 - 0.019 14.7 0.0 0.036 13.7 0.0 1.4 1 0 0 1 1 1 0 C2 domain of PTEN tumour-suppressor protein Transglut_core PF01841.14 KOO25276.1 - 0.085 13.0 0.0 0.27 11.4 0.0 1.9 1 0 0 1 1 1 0 Transglutaminase-like superfamily DUF972 PF06156.8 KOO25277.1 - 0.1 12.9 3.2 0.3 11.4 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF972) Kinesin-relat_1 PF12711.2 KOO25277.1 - 0.12 12.8 1.4 11 6.5 0.1 2.5 2 0 0 2 2 2 0 Kinesin motor Filament PF00038.16 KOO25277.1 - 0.27 10.6 12.6 1.3 8.4 2.2 2.3 1 1 1 2 2 2 0 Intermediate filament protein ADIP PF11559.3 KOO25277.1 - 1.1 9.1 12.5 0.079 12.8 0.7 2.5 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding TPR_11 PF13414.1 KOO25277.1 - 4.6 6.9 14.2 0.053 13.1 0.8 3.2 4 0 0 4 4 4 0 TPR repeat GTSE1_N PF15259.1 KOO25277.1 - 5.3 6.9 6.2 0.49 10.3 0.4 2.1 2 0 0 2 2 2 0 G-2 and S-phase expressed 1 TPT PF03151.11 KOO25278.1 - 1.5e-17 63.6 8.9 1.5e-17 63.6 6.2 1.8 2 1 0 2 2 2 1 Triose-phosphate Transporter family PPR_2 PF13041.1 KOO25279.1 - 6.7e-16 57.9 0.0 0.00019 21.3 0.0 5.3 3 1 2 5 5 5 4 PPR repeat family DnaJ PF00226.26 KOO25279.1 - 9.1e-14 50.9 0.2 2.4e-13 49.6 0.0 1.8 2 0 0 2 2 2 1 DnaJ domain PPR_3 PF13812.1 KOO25279.1 - 3.6e-11 42.4 1.2 0.053 13.8 0.0 6.0 5 0 0 5 5 5 2 Pentatricopeptide repeat domain PPR PF01535.15 KOO25279.1 - 3e-06 26.8 8.0 0.35 10.9 0.0 5.5 6 0 0 6 6 6 2 PPR repeat PPR_1 PF12854.2 KOO25279.1 - 0.00015 21.1 0.6 0.68 9.4 0.0 3.7 4 0 0 4 4 4 2 PPR repeat PALP PF00291.20 KOO25279.1 - 0.00024 20.4 0.2 0.00047 19.4 0.1 1.4 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ECSIT PF06239.6 KOO25279.1 - 0.0069 15.2 0.0 14 4.4 0.0 3.3 3 1 0 3 3 3 1 Evolutionarily conserved signalling intermediate in Toll pathway Nol1_Nop2_Fmu PF01189.12 KOO25281.1 - 2.7e-22 79.4 0.0 4.6e-22 78.7 0.0 1.3 1 0 0 1 1 1 1 NOL1/NOP2/sun family Methyltransf_26 PF13659.1 KOO25281.1 - 0.0002 21.3 0.0 0.00049 20.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.14 KOO25281.1 - 0.0021 18.0 0.0 0.0039 17.1 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.1 KOO25281.1 - 0.04 13.5 0.0 0.073 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Ribosomal_L4 PF00573.17 KOO25282.1 - 9.4e-42 142.5 0.1 1.6e-41 141.8 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.1 KOO25282.1 - 3.9e-21 74.7 5.3 1.7e-20 72.6 3.0 2.1 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain PolyA_pol PF01743.15 KOO25283.1 - 2.4e-06 27.8 0.2 1.1e-05 25.6 0.2 1.9 1 1 0 1 1 1 1 Poly A polymerase head domain 2OG-FeII_Oxy_3 PF13640.1 KOO25285.1 - 2.2e-16 60.1 0.1 3.7e-16 59.4 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO25285.1 - 8e-05 22.1 0.1 0.00015 21.3 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO25285.1 - 0.0025 18.0 0.0 0.0042 17.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Oxygenase-NA PF09859.4 KOO25285.1 - 0.014 14.7 0.0 0.021 14.1 0.0 1.4 1 0 0 1 1 1 0 Oxygenase, catalysing oxidative methylation of damaged DNA SET PF00856.23 KOO25287.1 - 1.6e-10 41.5 0.6 6.1e-09 36.3 0.0 2.9 2 1 0 2 2 2 1 SET domain Rieske PF00355.21 KOO25288.1 - 1.8e-19 69.1 0.1 3.5e-19 68.1 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.1 KOO25288.1 - 0.011 15.4 0.0 0.064 12.9 0.0 2.4 2 1 0 2 2 2 0 Rieske-like [2Fe-2S] domain GMC_oxred_N PF00732.14 KOO25289.1 - 9.6e-72 241.6 0.1 1.4e-71 241.0 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 KOO25289.1 - 3.5e-33 114.9 0.2 7e-33 113.9 0.2 1.5 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.1 KOO25289.1 - 4.9e-06 26.4 0.6 1.6e-05 24.8 0.4 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOO25289.1 - 3.2e-05 23.0 3.9 0.00025 20.0 0.7 3.1 1 1 1 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.9 KOO25289.1 - 7.6e-05 21.3 0.1 0.00012 20.7 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.7 KOO25289.1 - 0.00052 19.0 0.5 0.00081 18.4 0.3 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.19 KOO25289.1 - 0.0013 17.6 0.5 0.0029 16.5 0.4 1.6 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 KOO25289.1 - 0.0029 17.5 0.2 0.0064 16.3 0.2 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOO25289.1 - 0.025 14.9 0.3 0.096 13.0 0.2 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 KOO25289.1 - 0.089 11.8 0.1 0.24 10.4 0.1 1.7 1 0 0 1 1 1 0 Thi4 family LRR_6 PF13516.1 KOO25290.1 - 0.00012 21.8 1.3 12 6.2 0.0 5.8 6 1 1 7 7 7 2 Leucine Rich repeat Branch PF02485.16 KOO25293.1 - 3.9e-18 65.5 0.0 1.5e-17 63.5 0.0 1.7 1 1 0 1 1 1 1 Core-2/I-Branching enzyme Kinesin PF00225.18 KOO25294.1 - 1.5e-96 323.0 0.0 3.5e-96 321.8 0.0 1.6 1 0 0 1 1 1 1 Kinesin motor domain ABC_tran PF00005.22 KOO25295.1 - 6.6e-49 165.7 0.0 1.3e-27 96.7 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 KOO25295.1 - 8.6e-22 78.4 3.2 2.9e-06 27.4 0.3 4.1 4 0 0 4 4 4 4 AAA domain SMC_N PF02463.14 KOO25295.1 - 2e-10 40.2 0.3 0.072 12.3 0.0 4.1 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 KOO25295.1 - 2.1e-09 36.7 0.1 0.00073 19.0 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_tran_2 PF12848.2 KOO25295.1 - 1.4e-08 34.4 0.4 3.5e-08 33.1 0.2 1.7 2 0 0 2 2 1 1 ABC transporter AAA_17 PF13207.1 KOO25295.1 - 4.4e-08 33.9 0.0 0.0013 19.5 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.1 KOO25295.1 - 5.2e-08 33.4 0.0 0.0022 18.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 KOO25295.1 - 9.5e-08 31.3 0.0 0.0023 17.1 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 SbcCD_C PF13558.1 KOO25295.1 - 2.8e-06 27.1 1.8 0.041 13.7 0.1 3.8 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit Miro PF08477.8 KOO25295.1 - 3.8e-06 27.3 0.1 0.077 13.4 0.0 2.4 2 0 0 2 2 2 2 Miro-like protein AAA_33 PF13671.1 KOO25295.1 - 1.7e-05 24.7 0.2 0.28 11.0 0.0 2.8 3 0 0 3 3 2 2 AAA domain ArgK PF03308.11 KOO25295.1 - 2.1e-05 23.4 0.1 0.0039 16.0 0.0 2.5 2 0 0 2 2 2 1 ArgK protein MMR_HSR1 PF01926.18 KOO25295.1 - 2.4e-05 24.2 0.0 0.2 11.6 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.18 KOO25295.1 - 3e-05 23.8 0.3 0.23 11.2 0.0 2.5 2 0 0 2 2 2 2 Dynamin family AAA_16 PF13191.1 KOO25295.1 - 3.7e-05 23.7 4.3 0.055 13.4 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 KOO25295.1 - 0.00016 21.7 0.5 0.14 12.3 0.0 3.1 3 1 0 3 3 3 1 AAA domain AAA_28 PF13521.1 KOO25295.1 - 0.00034 20.6 0.0 0.22 11.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 KOO25295.1 - 0.00037 20.1 0.5 0.49 10.0 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_15 PF13175.1 KOO25295.1 - 0.00041 19.5 0.0 0.98 8.3 0.0 3.0 3 0 0 3 3 3 1 AAA ATPase domain Zeta_toxin PF06414.7 KOO25295.1 - 0.00049 19.2 0.4 0.63 9.1 0.2 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_25 PF13481.1 KOO25295.1 - 0.00082 18.8 3.4 0.98 8.7 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 KOO25295.1 - 0.0011 19.2 0.0 0.17 12.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 KOO25295.1 - 0.0015 18.2 0.1 0.54 9.9 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Mg_chelatase PF01078.16 KOO25295.1 - 0.0021 17.2 0.1 1.6 7.8 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 KOO25295.1 - 0.0048 17.0 0.1 4.2 7.5 0.0 2.4 2 0 0 2 2 2 0 RNA helicase PduV-EutP PF10662.4 KOO25295.1 - 0.0049 16.3 0.2 0.79 9.1 0.0 2.3 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA PF00004.24 KOO25295.1 - 0.0056 16.8 0.1 3.1 8.0 0.0 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 KOO25295.1 - 0.0088 15.5 0.3 2.5 7.4 0.0 2.3 2 0 0 2 2 2 1 AAA-like domain ATP-synt_ab PF00006.20 KOO25295.1 - 0.0095 15.4 0.1 0.61 9.5 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_24 PF13479.1 KOO25295.1 - 0.0095 15.5 0.0 1.7 8.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain ATP_bind_1 PF03029.12 KOO25295.1 - 0.013 15.0 0.1 0.1 12.0 0.0 2.2 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein DUF815 PF05673.8 KOO25295.1 - 0.016 14.1 0.4 0.33 9.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) FtsK_SpoIIIE PF01580.13 KOO25295.1 - 0.02 14.3 0.0 5.8 6.3 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family cobW PF02492.14 KOO25295.1 - 0.022 14.2 0.7 3.6 7.0 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MutS_V PF00488.16 KOO25295.1 - 0.022 14.1 0.0 7 5.9 0.0 2.2 2 0 0 2 2 2 0 MutS domain V AAA_14 PF13173.1 KOO25295.1 - 0.038 13.8 0.1 7.2 6.5 0.0 2.8 3 0 0 3 3 2 0 AAA domain AAA_5 PF07728.9 KOO25295.1 - 0.043 13.5 0.0 6.3 6.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF2813 PF11398.3 KOO25295.1 - 0.067 12.2 0.0 1.8 7.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2813) Guanylate_kin PF00625.16 KOO25295.1 - 0.075 12.4 0.0 11 5.4 0.0 2.2 2 0 0 2 2 2 0 Guanylate kinase AAA_30 PF13604.1 KOO25295.1 - 0.14 11.7 6.2 0.93 9.0 0.0 3.2 4 0 0 4 4 4 0 AAA domain Arf PF00025.16 KOO25295.1 - 0.21 10.8 0.1 8 5.6 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family FeoB_N PF02421.13 KOO25295.1 - 0.22 10.7 0.4 9.1 5.5 0.0 2.5 3 0 0 3 3 2 0 Ferrous iron transport protein B Pkinase PF00069.20 KOO25297.1 - 2.9e-54 183.9 0.0 3.4e-54 183.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25297.1 - 2.2e-24 85.9 0.0 2.8e-24 85.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO25297.1 - 3.8e-08 32.6 0.0 1.3e-07 30.9 0.0 1.7 1 1 0 2 2 2 1 Kinase-like Kdo PF06293.9 KOO25297.1 - 0.049 12.6 0.0 0.078 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Aldo_ket_red PF00248.16 KOO25298.1 - 2.3e-58 197.2 0.0 2.7e-58 197.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Ku PF02735.11 KOO25300.1 - 1.5e-28 99.5 0.0 2.2e-28 99.0 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.10 KOO25300.1 - 7e-27 94.2 0.0 1.6e-26 93.1 0.0 1.5 1 1 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain SAP PF02037.22 KOO25300.1 - 2.7e-09 36.3 0.0 5.3e-09 35.3 0.0 1.5 1 0 0 1 1 1 1 SAP domain Redoxin PF08534.5 KOO25302.1 - 2.7e-07 30.2 0.0 6.5e-07 28.9 0.0 1.6 1 1 0 1 1 1 1 Redoxin Thioredoxin PF00085.15 KOO25303.1 - 5.4e-17 61.3 0.0 6.4e-17 61.1 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin DNA_pol_A PF00476.15 KOO25303.1 - 0.036 12.6 0.0 0.038 12.6 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase family A Thioredoxin_2 PF13098.1 KOO25303.1 - 0.064 13.4 0.0 0.068 13.3 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain LrgB PF04172.11 KOO25304.1 - 1.8e-30 105.7 10.9 1.8e-30 105.7 7.6 1.9 1 1 0 1 1 1 1 LrgB-like family LrgA PF03788.9 KOO25304.1 - 4.4e-06 26.3 7.2 4.4e-06 26.3 5.0 3.3 3 1 2 5 5 5 1 LrgA family PX PF00787.19 KOO25305.1 - 3.9e-07 29.8 0.0 7.5e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 PX domain ARHGEF5_35 PF15441.1 KOO25305.1 - 0.017 13.9 5.4 0.026 13.3 3.8 1.2 1 0 0 1 1 1 0 Rho guanine nucleotide exchange factor 5/35 RNA_pol_Rpb1_5 PF04998.12 KOO25306.1 - 1.1e-82 277.4 0.0 1.5e-82 276.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 KOO25306.1 - 1.2e-49 168.4 0.0 2.2e-49 167.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 KOO25306.1 - 2e-33 115.3 0.0 4.3e-33 114.2 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 KOO25306.1 - 6.4e-17 61.2 0.0 1.3e-16 60.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 MIP-T3 PF10243.4 KOO25307.1 - 2.2e-63 214.5 7.8 2.1e-44 151.9 2.9 2.5 2 1 1 3 3 3 2 Microtubule-binding protein MIP-T3 Spc7 PF08317.6 KOO25307.1 - 0.17 10.5 1.0 0.25 9.9 0.7 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4618 PF15397.1 KOO25307.1 - 0.3 10.3 0.3 0.66 9.2 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) HMG_box PF00505.14 KOO25308.1 - 1.8e-20 72.9 0.2 4e-20 71.8 0.1 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO25308.1 - 1.4e-10 41.3 0.1 2.7e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 HMG-box domain MAT_Alpha1 PF04769.7 KOO25308.1 - 0.12 11.6 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 EF-hand_7 PF13499.1 KOO25309.1 - 1.2e-07 31.7 0.0 0.00089 19.3 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO25309.1 - 3e-07 29.2 2.7 0.0076 15.4 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO25309.1 - 7.8e-07 28.4 0.3 0.013 15.2 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO25309.1 - 5e-06 25.6 5.4 0.0033 16.6 0.2 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO25309.1 - 0.0034 16.9 0.9 0.74 9.4 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair Phasin_2 PF09361.5 KOO25309.1 - 0.12 12.4 0.5 0.23 11.5 0.4 1.5 1 0 0 1 1 1 0 Phasin protein Cation_ATPase_C PF00689.16 KOO25310.1 - 1.9e-17 63.4 2.6 2.7e-17 62.8 1.8 1.2 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus ABC2_membrane_3 PF12698.2 KOO25310.1 - 0.21 10.6 3.0 0.3 10.0 2.1 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein EF-hand_6 PF13405.1 KOO25311.1 - 0.00079 19.1 0.2 0.002 17.8 0.2 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.27 KOO25311.1 - 0.0012 18.0 0.1 0.0025 16.9 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO25311.1 - 0.03 14.4 0.0 0.069 13.2 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair DNMT1-RFD PF12047.3 KOO25312.1 - 0.0074 15.9 0.3 0.046 13.3 0.1 2.4 3 0 0 3 3 3 1 Cytosine specific DNA methyltransferase replication foci domain zf-RING_2 PF13639.1 KOO25313.1 - 0.0072 16.1 0.8 0.014 15.1 0.6 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 KOO25313.1 - 0.011 15.3 0.2 0.033 13.8 0.2 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RhoGEF PF00621.15 KOO25314.1 - 1.3e-39 135.9 0.0 2.5e-39 135.0 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.24 KOO25314.1 - 4.7e-13 49.2 0.0 1.1e-10 41.6 0.0 2.6 2 1 0 2 2 2 2 PH domain WW PF00397.21 KOO25314.1 - 8.1e-10 38.3 0.5 0.00047 19.9 0.0 2.6 2 0 0 2 2 2 2 WW domain PH_6 PF15406.1 KOO25314.1 - 0.018 15.1 0.0 0.066 13.2 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain TTL PF03133.10 KOO25315.1 - 8.5e-60 202.1 0.0 1.1e-59 201.7 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 KOO25315.1 - 1.1e-05 24.4 0.1 0.00012 21.0 0.0 2.3 2 1 1 3 3 3 1 YheC/D like ATP-grasp CRAL_TRIO PF00650.15 KOO25316.1 - 9.4e-18 64.1 0.0 1.5e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain DUF1769 PF08588.5 KOO25316.1 - 0.00065 19.5 0.1 0.0084 16.0 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1769) CRAL_TRIO_2 PF13716.1 KOO25316.1 - 0.0013 18.6 0.0 0.0022 17.9 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DUF747 PF05346.6 KOO25317.1 - 1.3e-96 323.6 2.5 1.8e-96 323.0 1.7 1.2 1 0 0 1 1 1 1 Eukaryotic membrane protein family FGGY_C PF02782.11 KOO25318.1 - 1.1e-16 61.0 0.1 2e-16 60.1 0.0 1.5 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 KOO25318.1 - 0.00027 20.3 0.0 0.00036 19.9 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Inhibitor_Mig-6 PF11555.3 KOO25318.1 - 0.65 10.4 4.8 6.1 7.3 0.1 2.7 2 0 0 2 2 2 0 EGFR receptor inhibitor Mig-6 zf-CW PF07496.10 KOO25319.1 - 6.4e-16 57.7 9.5 7.2e-15 54.4 7.5 2.1 2 0 0 2 2 2 1 CW-type Zinc Finger SET PF00856.23 KOO25319.1 - 2.1e-10 41.1 0.0 7.4e-09 36.1 0.0 2.7 2 1 0 2 2 2 1 SET domain Thioredoxin PF00085.15 KOO25320.1 - 1.7e-32 111.2 0.0 4.2e-30 103.5 0.0 2.1 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.1 KOO25320.1 - 5.2e-07 29.8 0.0 8e-06 26.0 0.0 2.5 2 1 0 2 2 2 1 Thioredoxin-like domain Calsequestrin PF01216.12 KOO25320.1 - 3.6e-05 22.7 0.0 5e-05 22.2 0.0 1.3 1 1 0 1 1 1 1 Calsequestrin Thioredoxin_7 PF13899.1 KOO25320.1 - 0.00074 19.4 0.0 0.0013 18.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_8 PF13905.1 KOO25320.1 - 0.00084 19.4 0.0 0.0082 16.2 0.0 2.1 1 1 1 2 2 2 1 Thioredoxin-like Kelch_6 PF13964.1 KOO25320.1 - 0.024 14.8 0.2 0.069 13.3 0.0 1.9 2 0 0 2 2 2 0 Kelch motif Kelch_4 PF13418.1 KOO25320.1 - 0.056 13.2 0.8 0.11 12.2 0.6 1.5 1 0 0 1 1 1 0 Galactose oxidase, central domain Hist_deacetyl PF00850.14 KOO25321.1 - 2.6e-74 250.3 0.0 2.6e-74 250.3 0.0 1.9 2 0 0 2 2 2 1 Histone deacetylase domain zf-ZPR1 PF03367.8 KOO25321.1 - 0.094 11.8 0.1 0.2 10.8 0.1 1.5 1 0 0 1 1 1 0 ZPR1 zinc-finger domain B12-binding PF02310.14 KOO25321.1 - 0.6 9.9 5.2 3 7.7 0.0 4.0 3 1 0 3 3 3 0 B12 binding domain 60KD_IMP PF02096.15 KOO25322.1 - 3.7e-36 124.6 0.0 5e-36 124.2 0.0 1.1 1 0 0 1 1 1 1 60Kd inner membrane protein Cwf_Cwc_15 PF04889.7 KOO25324.1 - 4.3e-37 128.1 4.1 4.7e-37 128.0 2.8 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein DUF2890 PF11081.3 KOO25324.1 - 0.019 14.9 1.4 0.023 14.7 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) HEAT_2 PF13646.1 KOO25325.1 - 5.2e-12 45.8 21.3 5.5e-05 23.3 0.3 6.3 2 2 0 3 3 3 3 HEAT repeats Arm PF00514.18 KOO25325.1 - 2.4e-09 36.6 24.5 0.0052 16.5 0.4 7.3 6 1 0 6 6 6 3 Armadillo/beta-catenin-like repeat HEAT PF02985.17 KOO25325.1 - 1.1e-08 34.4 18.7 0.0027 17.6 0.0 6.4 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.1 KOO25325.1 - 0.00033 21.0 24.2 0.029 14.8 0.5 6.8 4 2 3 8 8 8 5 HEAT-like repeat Adaptin_N PF01602.15 KOO25325.1 - 0.0013 17.1 1.5 0.015 13.6 0.8 2.5 1 1 1 2 2 2 1 Adaptin N terminal region RICTOR_V PF14668.1 KOO25325.1 - 0.0057 16.5 0.6 0.0057 16.5 0.4 3.0 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, domain 5 Proteasom_PSMB PF10508.4 KOO25325.1 - 0.013 13.8 4.8 0.011 14.0 1.0 2.2 2 1 1 3 3 3 0 Proteasome non-ATPase 26S subunit Cnd1 PF12717.2 KOO25325.1 - 0.091 12.5 0.9 18 5.1 0.0 3.5 3 1 1 4 4 4 0 non-SMC mitotic condensation complex subunit 1 DUF760 PF05542.6 KOO25327.1 - 2e-27 95.1 1.6 1.8e-16 60.0 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF760) EF-hand_1 PF00036.27 KOO25327.1 - 1.8e-12 45.6 0.0 6.2e-05 22.0 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO25327.1 - 3.2e-12 46.3 0.0 8.8e-12 44.9 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO25327.1 - 1e-10 40.5 0.0 0.0005 19.7 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO25327.1 - 4.8e-08 31.9 0.0 0.0019 17.4 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO25327.1 - 8.5e-08 31.7 0.0 0.00011 21.7 0.0 2.8 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO25327.1 - 0.033 14.2 0.0 0.15 12.0 0.0 2.0 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF3745 PF12560.3 KOO25327.1 - 0.078 12.6 0.3 0.21 11.3 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3745) Syntaxin PF00804.20 KOO25327.1 - 0.083 13.0 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Syntaxin FAD_binding_3 PF01494.14 KOO25329.1 - 5.9e-09 35.4 0.6 8.5e-09 34.9 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 KOO25329.1 - 7.2e-08 31.7 0.1 1.3e-07 30.9 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 KOO25329.1 - 8.7e-07 27.7 0.1 1.1e-06 27.3 0.1 1.1 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.19 KOO25329.1 - 3e-06 26.3 0.5 4.7e-06 25.7 0.1 1.4 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.12 KOO25329.1 - 7.6e-06 25.1 0.1 1.1e-05 24.6 0.1 1.1 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.2 KOO25329.1 - 9.2e-06 24.9 0.9 1.5e-05 24.2 0.6 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 KOO25329.1 - 1e-05 25.4 0.1 1e-05 25.4 0.1 2.3 3 0 0 3 3 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 KOO25329.1 - 3e-05 24.0 0.2 4.7e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOO25329.1 - 3e-05 24.3 0.3 8.2e-05 22.9 0.3 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.16 KOO25329.1 - 9.1e-05 22.0 0.8 0.00014 21.4 0.5 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.17 KOO25329.1 - 9.6e-05 21.4 0.3 0.00013 20.9 0.2 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A ApbA PF02558.11 KOO25329.1 - 0.00027 20.4 0.1 0.00041 19.8 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ThiF PF00899.16 KOO25329.1 - 0.0012 18.6 0.7 0.0019 18.0 0.5 1.3 1 0 0 1 1 1 1 ThiF family Pyr_redox_3 PF13738.1 KOO25329.1 - 0.0013 18.8 0.1 0.0023 18.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 KOO25329.1 - 0.0096 15.0 0.0 0.068 12.2 0.0 1.9 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase 3HCDH_N PF02737.13 KOO25329.1 - 0.01 15.5 0.1 0.021 14.4 0.1 1.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.7 KOO25329.1 - 0.02 13.8 0.2 0.032 13.1 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_7 PF13241.1 KOO25329.1 - 0.029 14.6 0.1 0.052 13.8 0.1 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Trp_halogenase PF04820.9 KOO25329.1 - 0.042 12.4 0.1 0.056 12.0 0.0 1.1 1 0 0 1 1 1 0 Tryptophan halogenase WD40 PF00400.27 KOO25331.1 - 7.2e-91 295.1 12.1 7.1e-12 44.7 0.0 8.1 8 0 0 8 8 8 8 WD domain, G-beta repeat Nup160 PF11715.3 KOO25331.1 - 2.1e-08 32.7 9.8 0.2 9.7 0.0 6.4 1 1 4 5 5 5 5 Nucleoporin Nup120/160 eIF2A PF08662.6 KOO25331.1 - 2.5e-07 30.6 1.4 0.12 12.0 0.0 3.3 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.6 KOO25331.1 - 0.0007 18.4 0.2 0.3 9.7 0.0 3.0 1 1 1 2 2 2 2 Nup133 N terminal like HTH_Tnp_IS1 PF12759.2 KOO25331.1 - 0.12 11.7 0.1 2.4 7.6 0.0 2.7 2 0 0 2 2 2 0 InsA C-terminal domain Seryl_tRNA_N PF02403.17 KOO25332.1 - 2.6e-22 78.8 3.1 3.9e-22 78.3 2.1 1.2 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain AAA PF00004.24 KOO25333.1 - 2.3e-42 144.2 0.1 7.3e-42 142.6 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 KOO25333.1 - 4.1e-06 26.8 0.0 8.3e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 KOO25333.1 - 1.3e-05 25.2 0.1 6.3e-05 23.0 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.9 KOO25333.1 - 3.3e-05 23.6 0.0 0.00015 21.5 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 KOO25333.1 - 3.4e-05 24.0 0.2 0.0017 18.5 0.1 2.8 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.7 KOO25333.1 - 9.4e-05 21.5 0.0 0.00023 20.2 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 KOO25333.1 - 0.00016 22.5 0.1 0.00047 20.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 KOO25333.1 - 0.00033 20.5 0.1 0.0012 18.6 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KOO25333.1 - 0.00055 19.6 0.1 0.0013 18.4 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain DUF2072 PF09845.4 KOO25333.1 - 0.00065 19.6 0.2 0.0018 18.1 0.1 1.7 1 0 0 1 1 1 1 Zn-ribbon containing protein (DUF2072) IstB_IS21 PF01695.12 KOO25333.1 - 0.0011 18.4 0.0 0.0019 17.6 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein Zeta_toxin PF06414.7 KOO25333.1 - 0.0027 16.8 0.0 0.0065 15.5 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin Mg_chelatase PF01078.16 KOO25333.1 - 0.0035 16.5 0.1 0.0075 15.4 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI PhoH PF02562.11 KOO25333.1 - 0.004 16.3 0.1 0.055 12.6 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein AAA_3 PF07726.6 KOO25333.1 - 0.005 16.4 0.0 0.021 14.4 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.8 KOO25333.1 - 0.0057 15.4 0.0 0.011 14.4 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus AAA_28 PF13521.1 KOO25333.1 - 0.013 15.5 0.0 0.027 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 KOO25333.1 - 0.014 15.3 0.0 0.024 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 KOO25333.1 - 0.015 14.7 0.2 0.11 11.9 0.0 2.4 3 0 0 3 3 2 0 Sigma-54 interaction domain AAA_24 PF13479.1 KOO25333.1 - 0.019 14.5 0.0 0.037 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain KaiC PF06745.8 KOO25333.1 - 0.025 13.6 0.0 0.1 11.6 0.0 2.0 2 0 0 2 2 2 0 KaiC AAA_18 PF13238.1 KOO25333.1 - 0.028 14.7 0.1 0.13 12.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.1 KOO25333.1 - 0.041 13.2 0.2 0.27 10.5 0.0 2.2 1 1 1 2 2 2 0 AAA domain NB-ARC PF00931.17 KOO25333.1 - 0.055 12.3 0.0 0.32 9.8 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain RNA_helicase PF00910.17 KOO25333.1 - 0.063 13.4 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Parvo_NS1 PF01057.12 KOO25333.1 - 0.063 12.1 0.0 0.1 11.4 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NACHT PF05729.7 KOO25333.1 - 0.11 12.1 0.0 1.1 8.9 0.0 2.4 3 0 0 3 3 2 0 NACHT domain V_ATPase_I PF01496.14 KOO25333.1 - 0.12 10.2 0.0 0.21 9.3 0.0 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Sigma54_activ_2 PF14532.1 KOO25333.1 - 0.12 12.3 0.1 0.65 10.0 0.0 2.4 3 0 0 3 3 2 0 Sigma-54 interaction domain LRR_4 PF12799.2 KOO25334.1 - 3.3e-28 96.7 46.3 2.7e-08 33.2 0.7 10.5 9 1 2 11 11 11 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO25334.1 - 3.4e-17 61.9 44.5 2.9e-06 26.9 1.2 7.7 6 1 1 7 7 7 4 Leucine rich repeat LRR_6 PF13516.1 KOO25334.1 - 3e-12 45.2 54.3 0.00058 19.6 0.6 16.4 17 0 0 17 17 17 3 Leucine Rich repeat LRR_1 PF00560.28 KOO25334.1 - 1.5e-11 42.6 43.7 0.11 12.5 0.1 13.4 14 0 0 14 14 13 4 Leucine Rich Repeat LRR_7 PF13504.1 KOO25334.1 - 5.4e-07 28.7 44.8 0.99 9.8 0.1 13.3 15 0 0 15 15 12 5 Leucine rich repeat ART PF01129.13 KOO25334.1 - 0.00018 20.6 0.0 0.00043 19.4 0.0 1.5 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Ras PF00071.17 KOO25334.1 - 0.00033 20.0 0.0 0.00068 19.0 0.0 1.5 1 0 0 1 1 1 1 Ras family ADPrib_exo_Tox PF03496.9 KOO25334.1 - 0.00051 19.3 0.0 0.0013 17.9 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Arf PF00025.16 KOO25334.1 - 0.065 12.4 0.0 0.34 10.1 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family Miro PF08477.8 KOO25334.1 - 0.14 12.6 0.0 0.5 10.8 0.0 2.1 2 0 0 2 2 1 0 Miro-like protein DUF2357 PF09823.4 KOO25334.1 - 0.4 9.7 0.1 1 8.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2357) EF-hand_1 PF00036.27 KOO25338.1 - 3.3e-11 41.6 0.2 4.7e-05 22.3 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO25338.1 - 5.2e-11 42.5 1.7 1.8e-07 31.1 0.2 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO25338.1 - 4.2e-10 38.6 0.0 0.00055 19.6 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO25338.1 - 4.7e-07 29.3 0.3 0.016 14.7 0.1 2.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO25338.1 - 3.2e-06 26.2 0.7 0.0073 15.6 0.0 2.8 3 0 0 3 3 3 2 EF hand Arm PF00514.18 KOO25339.1 - 6.8e-65 212.8 54.8 3.5e-07 29.8 0.0 14.9 15 0 0 15 15 15 14 Armadillo/beta-catenin-like repeat PARP PF00644.15 KOO25339.1 - 3.9e-14 52.5 0.0 6.4e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Nucleoporin_FG PF13634.1 KOO25339.1 - 3.3e-11 43.4 20.6 1.4e-06 28.5 1.4 3.4 2 2 0 2 2 2 2 Nucleoporin FG repeat region WWE PF02825.15 KOO25339.1 - 4.7e-06 25.9 0.0 8.1e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 WWE domain Arm_2 PF04826.8 KOO25339.1 - 5.5e-06 25.6 0.0 12 4.9 0.0 5.7 3 2 1 6 6 6 3 Armadillo-like WD40 PF00400.27 KOO25340.1 - 1.9e-35 119.4 7.5 1.1e-09 37.7 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat Nucleoporin_N PF08801.6 KOO25340.1 - 0.00054 18.8 0.0 0.18 10.5 0.0 2.5 2 0 0 2 2 2 2 Nup133 N terminal like PQQ_3 PF13570.1 KOO25340.1 - 0.0011 19.1 4.3 1.4 9.2 0.0 5.4 5 1 0 5 5 5 1 PQQ-like domain PQQ_2 PF13360.1 KOO25340.1 - 0.0036 16.7 0.1 0.026 14.0 0.0 2.2 1 1 0 1 1 1 1 PQQ-like domain Nup160 PF11715.3 KOO25340.1 - 0.014 13.5 2.0 5.3 5.0 0.0 4.3 2 2 2 4 4 4 0 Nucleoporin Nup120/160 Peptidase_M24 PF00557.19 KOO25341.1 - 6.8e-44 149.9 0.0 1.1e-43 149.2 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 IQ PF00612.22 KOO25342.1 - 8.2e-06 25.0 11.8 0.13 11.9 0.2 3.9 3 0 0 3 3 3 3 IQ calmodulin-binding motif NAD_binding_10 PF13460.1 KOO25343.1 - 1.4e-13 51.2 0.0 6.3e-13 49.1 0.0 2.0 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 KOO25343.1 - 3.2e-10 39.8 0.0 5.9e-09 35.6 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 KOO25343.1 - 3e-05 22.8 0.0 5.1e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 KOO25343.1 - 0.0031 17.4 0.0 0.0057 16.5 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.8 KOO25343.1 - 0.04 13.1 0.0 0.067 12.4 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family NAD_binding_4 PF07993.7 KOO25343.1 - 0.14 11.0 0.0 2.2 7.1 0.0 2.2 2 0 0 2 2 2 0 Male sterility protein Cupin_8 PF13621.1 KOO25344.1 - 8.7e-30 104.0 0.1 4.4e-29 101.7 0.0 1.9 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 KOO25344.1 - 0.0023 17.2 0.1 0.05 12.8 0.0 2.6 2 1 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.17 KOO25344.1 - 0.0036 17.5 0.0 0.013 15.7 0.0 2.0 2 0 0 2 2 2 1 JmjC domain, hydroxylase DUF904 PF06005.7 KOO25345.1 - 0.11 12.8 3.3 2.9 8.2 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF904) DUF2730 PF10805.3 KOO25345.1 - 0.17 11.6 2.3 8.3 6.2 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) DUF2937 PF11157.3 KOO25345.1 - 0.42 9.9 2.8 1.3 8.3 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) DUF4200 PF13863.1 KOO25345.1 - 0.76 9.7 8.2 9.8 6.1 2.6 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) CENP-F_leu_zip PF10473.4 KOO25345.1 - 0.91 9.3 12.3 3.5 7.4 0.1 2.6 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DNA_pol_A_exo1 PF01612.15 KOO25346.1 - 1.5e-13 50.6 0.0 2.4e-06 27.1 0.0 2.0 2 0 0 2 2 2 2 3'-5' exonuclease DUF2453 PF10507.4 KOO25346.1 - 0.0031 17.3 0.0 0.44 10.3 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF2453) DEC-1_N PF04625.8 KOO25346.1 - 0.032 12.9 1.0 0.04 12.6 0.7 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Gly-zipper_Omp PF13488.1 KOO25346.1 - 0.25 10.9 10.2 0.61 9.7 7.1 1.6 1 0 0 1 1 1 0 Glycine zipper Gly-zipper_OmpA PF13436.1 KOO25346.1 - 8.2 6.1 11.4 15 5.3 7.9 1.3 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Filamin PF00630.14 KOO25347.1 - 0.0029 18.1 0.0 0.0052 17.3 0.0 1.5 1 0 0 1 1 1 1 Filamin/ABP280 repeat SlyX PF04102.7 KOO25348.1 - 2.3 8.6 7.6 1.1 9.6 1.9 3.1 3 1 1 4 4 4 0 SlyX CPSase_L_D2 PF02786.12 KOO25349.1 - 2.5e-65 219.6 0.0 4e-65 219.0 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 KOO25349.1 - 1.5e-40 137.7 0.1 5.4e-40 135.9 0.1 2.1 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 KOO25349.1 - 3.5e-31 107.3 0.1 8.8e-21 73.9 0.0 3.2 3 1 1 4 4 4 2 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.17 KOO25349.1 - 5.4e-14 51.5 0.1 1.2e-13 50.5 0.1 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.1 KOO25349.1 - 2.1e-12 46.4 0.0 3.1e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_4 PF13535.1 KOO25349.1 - 7.8e-11 42.0 0.1 1.7e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.1 KOO25349.1 - 1.5e-08 34.1 0.2 8.1e-08 31.8 0.1 2.2 1 1 0 1 1 1 1 Biotin-lipoyl like Dala_Dala_lig_C PF07478.8 KOO25349.1 - 1.3e-06 27.9 0.0 2.5e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus HlyD_3 PF13437.1 KOO25349.1 - 0.00013 22.2 0.4 0.87 9.9 0.0 3.3 3 0 0 3 3 3 2 HlyD family secretion protein ATP-grasp PF02222.17 KOO25349.1 - 0.00031 20.1 0.0 0.00083 18.7 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain HlyD PF00529.15 KOO25349.1 - 0.0013 18.0 0.1 0.0024 17.2 0.1 1.4 1 0 0 1 1 1 1 HlyD family secretion protein Cytochrom_B561 PF03188.11 KOO25350.1 - 0.0028 17.4 1.6 0.0028 17.4 1.1 1.9 2 1 0 2 2 2 1 Eukaryotic cytochrome b561 COX15-CtaA PF02628.10 KOO25350.1 - 0.0068 15.3 7.5 0.25 10.1 0.6 2.5 2 1 0 2 2 2 2 Cytochrome oxidase assembly protein DUF2306 PF10067.4 KOO25350.1 - 0.017 15.2 5.1 0.38 10.9 0.1 2.9 2 1 0 2 2 2 0 Predicted membrane protein (DUF2306) Tmemb_170 PF10190.4 KOO25350.1 - 0.08 13.0 0.6 0.08 13.0 0.4 1.8 2 0 0 2 2 2 0 Putative transmembrane protein 170 DUF2427 PF10348.4 KOO25350.1 - 0.21 11.2 7.9 1.8 8.1 0.1 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF2427) Peptidase_S8 PF00082.17 KOO25351.1 - 1.7e-56 191.4 0.3 2.4e-56 190.9 0.2 1.2 1 0 0 1 1 1 1 Subtilase family TPPII PF12580.3 KOO25351.1 - 2.2e-36 125.0 0.0 1e-35 122.8 0.0 1.9 2 0 0 2 2 2 1 Tripeptidyl peptidase II IMPDH PF00478.20 KOO25352.1 - 4.3e-135 450.1 1.4 5e-135 449.9 1.0 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.23 KOO25352.1 - 2.7e-15 55.8 0.0 1.9e-08 33.9 0.0 2.6 2 0 0 2 2 2 2 CBS domain NMO PF03060.10 KOO25352.1 - 2.7e-10 39.9 3.3 3.5e-08 32.9 2.3 2.3 1 1 0 1 1 1 1 Nitronate monooxygenase FMN_dh PF01070.13 KOO25352.1 - 9.7e-08 31.2 0.5 7.5e-07 28.3 0.6 2.2 2 0 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.16 KOO25352.1 - 5.5e-05 22.5 0.1 0.0025 17.1 0.0 2.5 1 1 1 2 2 2 1 Histidine biosynthesis protein NanE PF04131.9 KOO25352.1 - 0.012 14.5 0.1 0.032 13.2 0.1 1.8 1 1 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase B12-binding PF02310.14 KOO25352.1 - 0.049 13.5 0.1 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 B12 binding domain DUF1273 PF06908.6 KOO25352.1 - 0.095 12.3 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1273) PseudoU_synth_2 PF00849.17 KOO25353.1 - 2.7e-26 92.3 0.0 3.7e-26 91.9 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase Filamin PF00630.14 KOO25355.1 - 1.3e-25 89.9 0.0 4.6e-07 30.3 0.0 5.6 5 0 0 5 5 5 5 Filamin/ABP280 repeat C2 PF00168.25 KOO25355.1 - 3.5e-13 49.1 0.0 1e-12 47.6 0.0 1.8 1 0 0 1 1 1 1 C2 domain Big_1 PF02369.11 KOO25355.1 - 7.5e-05 22.5 0.0 0.027 14.3 0.0 3.6 3 1 0 3 3 3 1 Bacterial Ig-like domain (group 1) Y_Y_Y PF07495.8 KOO25355.1 - 0.025 14.3 0.0 5.7 6.7 0.0 3.1 3 0 0 3 3 3 0 Y_Y_Y domain HSP70 PF00012.15 KOO25356.1 - 3.5e-238 791.4 0.3 4e-238 791.2 0.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KOO25356.1 - 6.1e-16 57.9 0.7 2.9e-15 55.6 0.1 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.1 KOO25356.1 - 0.018 14.8 2.7 0.2 11.4 0.1 3.3 2 1 0 2 2 2 0 Cell division protein FtsA Hydantoinase_A PF01968.13 KOO25356.1 - 0.043 12.9 1.6 0.084 11.9 0.1 2.2 2 1 1 3 3 3 0 Hydantoinase/oxoprolinase Beach PF02138.13 KOO25357.1 - 9e-90 300.7 0.0 1.1e-89 300.4 0.0 1.1 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.1 KOO25357.1 - 4e-09 36.2 0.0 6.5e-07 29.1 0.0 3.1 2 1 0 2 2 2 1 PH domain associated with Beige/BEACH zf-RING_2 PF13639.1 KOO25358.1 - 4.3e-12 45.6 13.9 2.1e-10 40.2 4.5 2.7 2 0 0 2 2 2 2 Ring finger domain zf-C3HC4 PF00097.20 KOO25358.1 - 1.6e-08 34.0 7.3 1.6e-08 34.0 5.1 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO25358.1 - 6.3e-08 32.1 4.3 6.3e-08 32.1 3.0 2.7 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO25358.1 - 4.2e-05 23.4 7.4 4.2e-05 23.4 5.1 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 KOO25358.1 - 0.00017 21.6 4.3 0.00017 21.6 3.0 2.2 2 1 0 2 2 2 1 RING-H2 zinc finger zf-Apc11 PF12861.2 KOO25358.1 - 0.0015 18.3 2.9 0.0085 15.9 2.0 2.2 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.1 KOO25358.1 - 0.0082 15.8 5.4 0.0082 15.8 3.7 2.6 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 KOO25358.1 - 0.043 13.5 3.5 0.2 11.3 2.5 2.3 1 0 0 1 1 1 0 RING-type zinc-finger zf-primase PF09329.6 KOO25358.1 - 0.045 13.3 1.1 0.13 11.8 0.8 1.8 1 0 0 1 1 1 0 Primase zinc finger DUF4207 PF13904.1 KOO25358.1 - 0.52 9.6 11.3 0.069 12.5 4.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) zf-C3HC4_4 PF15227.1 KOO25358.1 - 0.58 10.0 12.2 0.019 14.8 3.4 2.4 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING Baculo_RING PF05883.6 KOO25358.1 - 1.3 8.8 3.1 4.1 7.2 0.2 2.3 2 0 0 2 2 2 0 Baculovirus U-box/Ring-like domain FANCL_C PF11793.3 KOO25358.1 - 1.8 8.5 7.1 0.32 11.0 1.5 2.3 2 0 0 2 2 2 0 FANCL C-terminal domain Cellulase PF00150.13 KOO25359.1 - 8.7e-15 54.6 0.0 1.1e-14 54.3 0.0 1.0 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) AAA_25 PF13481.1 KOO25359.1 - 0.12 11.7 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain P12 PF12669.2 KOO25361.1 - 0.0011 19.0 0.6 0.0019 18.3 0.4 1.3 1 0 0 1 1 1 1 Virus attachment protein p12 family Adeno_E3_CR2 PF02439.10 KOO25361.1 - 0.012 15.1 0.3 0.031 13.8 0.2 1.8 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 RCR PF12273.3 KOO25361.1 - 0.051 14.1 0.0 0.091 13.3 0.0 1.4 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red TctB PF07331.6 KOO25361.1 - 0.056 13.1 2.9 0.09 12.4 2.0 1.3 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family Glycophorin_A PF01102.13 KOO25361.1 - 0.13 12.0 5.4 0.37 10.5 3.7 1.9 1 1 0 1 1 1 0 Glycophorin A DUF441 PF04284.8 KOO25361.1 - 0.16 11.8 8.0 2.6 7.9 5.5 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF441) MtrF PF09472.5 KOO25361.1 - 0.21 10.8 4.9 0.079 12.2 1.1 2.0 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) DUF751 PF05421.6 KOO25361.1 - 1.2 9.4 5.3 4.8 7.5 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF751) DUF4064 PF13273.1 KOO25361.1 - 1.3 9.1 7.7 19 5.4 5.3 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) DUF4231 PF14015.1 KOO25361.1 - 3.6 7.5 5.8 0.65 10.0 0.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) DUF4199 PF13858.1 KOO25361.1 - 5 7.0 7.9 19 5.1 5.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4199) TPR_11 PF13414.1 KOO25363.1 - 6.1e-31 105.8 6.8 6.3e-11 41.7 0.2 4.9 3 2 2 5 5 5 4 TPR repeat TPR_2 PF07719.12 KOO25363.1 - 5.5e-19 66.5 16.0 0.0022 17.7 0.0 7.4 8 0 0 8 8 6 5 Tetratricopeptide repeat TPR_1 PF00515.23 KOO25363.1 - 5.4e-15 54.2 16.2 0.011 15.3 0.1 7.0 7 0 0 7 7 6 6 Tetratricopeptide repeat TPR_19 PF14559.1 KOO25363.1 - 1.1e-13 51.3 5.5 0.0026 18.0 0.5 5.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO25363.1 - 1.3e-12 48.0 24.6 0.00041 20.9 0.0 5.7 5 1 0 5 5 4 4 Tetratricopeptide repeat Methyltransf_18 PF12847.2 KOO25363.1 - 1.7e-11 44.6 0.9 1.6e-09 38.3 0.1 3.7 4 0 0 4 4 3 1 Methyltransferase domain TPR_14 PF13428.1 KOO25363.1 - 2.7e-11 43.0 8.9 0.19 12.4 1.5 7.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO25363.1 - 1.5e-10 40.0 4.0 1.4 8.8 0.0 6.6 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO25363.1 - 7e-10 38.3 1.7 1.1 9.6 0.0 6.6 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO25363.1 - 3.2e-08 33.3 16.4 0.00029 20.7 0.2 5.7 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO25363.1 - 1e-06 28.0 6.1 0.081 12.7 0.0 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat Apc3 PF12895.2 KOO25363.1 - 1.1e-05 25.4 7.2 0.0074 16.4 0.1 3.8 2 2 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 Methyltransf_26 PF13659.1 KOO25363.1 - 2.3e-05 24.3 10.1 0.0044 17.0 0.3 4.1 2 1 1 3 3 3 2 Methyltransferase domain MTS PF05175.9 KOO25363.1 - 3.1e-05 23.4 0.1 0.00013 21.4 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase small domain TPR_9 PF13371.1 KOO25363.1 - 0.00015 21.5 13.8 0.51 10.2 0.2 5.8 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.1 KOO25363.1 - 0.0026 18.0 13.9 4.2 8.0 1.0 6.6 6 0 0 6 6 6 1 Tetratricopeptide repeat BTAD PF03704.12 KOO25363.1 - 0.011 15.9 8.5 0.16 12.2 0.2 3.7 2 1 0 2 2 2 0 Bacterial transcriptional activator domain Met_10 PF02475.11 KOO25363.1 - 0.018 14.6 0.0 0.039 13.5 0.0 1.5 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_25 PF13649.1 KOO25363.1 - 0.036 14.4 0.4 0.36 11.2 0.1 2.6 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_3 PF01596.12 KOO25363.1 - 0.041 12.9 0.0 0.35 9.8 0.0 2.2 2 0 0 2 2 2 0 O-methyltransferase PRMT5 PF05185.11 KOO25363.1 - 0.058 12.3 0.0 7.7 5.3 0.0 2.2 2 0 0 2 2 2 0 PRMT5 arginine-N-methyltransferase Methyltransf_12 PF08242.7 KOO25363.1 - 0.07 13.6 0.2 1.3 9.4 0.0 2.8 3 0 0 3 3 2 0 Methyltransferase domain TPR_10 PF13374.1 KOO25363.1 - 1.1 9.2 15.3 13 5.9 0.1 5.0 4 0 0 4 4 4 0 Tetratricopeptide repeat CBAH PF02275.13 KOO25364.1 - 5.3e-21 75.3 0.0 4.2e-14 52.7 0.0 2.2 2 0 0 2 2 2 2 Linear amide C-N hydrolases, choloylglycine hydrolase family AAA PF00004.24 KOO25365.1 - 2.8e-42 144.0 0.0 6.9e-42 142.7 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 KOO25365.1 - 1.1e-05 25.0 2.7 3.3e-05 23.5 0.0 3.1 2 1 1 3 3 2 1 Part of AAA domain AAA_16 PF13191.1 KOO25365.1 - 1.2e-05 25.3 3.1 0.00066 19.7 0.1 3.1 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.7 KOO25365.1 - 4.5e-05 22.5 0.0 8.9e-05 21.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KOO25365.1 - 9e-05 22.6 0.0 0.0025 17.9 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO25365.1 - 0.00034 21.4 0.0 0.00073 20.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 KOO25365.1 - 0.00035 20.0 0.1 0.00071 19.0 0.1 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.1 KOO25365.1 - 0.00064 19.6 0.0 0.0017 18.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 KOO25365.1 - 0.00096 18.8 0.1 0.0036 17.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) KaiC PF06745.8 KOO25365.1 - 0.0019 17.3 0.0 0.0034 16.5 0.0 1.3 1 0 0 1 1 1 1 KaiC TIP49 PF06068.8 KOO25365.1 - 0.002 16.9 0.0 0.0028 16.4 0.0 1.1 1 0 0 1 1 1 1 TIP49 C-terminus AAA_2 PF07724.9 KOO25365.1 - 0.0041 17.0 0.0 0.0091 15.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_25 PF13481.1 KOO25365.1 - 0.0087 15.4 3.4 0.11 11.8 0.1 2.9 2 1 1 3 3 3 1 AAA domain Mg_chelatase PF01078.16 KOO25365.1 - 0.0098 15.0 0.5 0.029 13.5 0.3 1.7 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI PhoH PF02562.11 KOO25365.1 - 0.019 14.2 0.1 0.034 13.3 0.1 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_14 PF13173.1 KOO25365.1 - 0.027 14.3 0.0 0.04 13.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 KOO25365.1 - 0.036 13.5 0.1 0.25 10.7 0.0 2.3 3 0 0 3 3 3 0 Sigma-54 interaction domain NACHT PF05729.7 KOO25365.1 - 0.038 13.6 0.1 0.2 11.3 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_18 PF13238.1 KOO25365.1 - 0.048 13.9 0.0 0.084 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.6 KOO25365.1 - 0.065 12.8 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 KOO25365.1 - 0.076 13.1 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 RNA helicase ResIII PF04851.10 KOO25365.1 - 0.1 12.4 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Sigma54_activ_2 PF14532.1 KOO25365.1 - 0.11 12.5 0.0 0.28 11.2 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.7 KOO25365.1 - 0.11 11.5 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_11 PF13086.1 KOO25365.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.4 KOO25365.1 - 0.14 11.1 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Parvo_NS1 PF01057.12 KOO25365.1 - 0.16 10.8 0.0 0.24 10.2 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NB-ARC PF00931.17 KOO25365.1 - 0.21 10.4 0.0 0.33 9.7 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain MOZART1 PF12554.3 KOO25366.1 - 4.1e-23 80.5 0.1 6.4e-23 79.9 0.1 1.3 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated MOZART2 PF12926.2 KOO25366.1 - 0.0037 16.8 0.1 0.0058 16.2 0.0 1.4 1 1 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated DEAD PF00270.24 KOO25367.1 - 8.8e-28 96.8 0.2 1.3e-27 96.3 0.1 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO25367.1 - 2.9e-12 46.2 0.0 5.8e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO25367.1 - 0.00013 21.8 0.0 0.00029 20.6 0.0 1.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.1 KOO25367.1 - 0.0043 16.6 0.2 0.012 15.2 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.1 KOO25367.1 - 0.11 12.0 0.0 3.2 7.2 0.0 2.1 1 1 1 2 2 2 0 AAA domain TAXi_C PF14541.1 KOO25369.1 - 1.3e-28 99.5 0.0 1.9e-28 99.0 0.0 1.3 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Asp PF00026.18 KOO25369.1 - 5.7e-26 91.5 0.0 1.3e-25 90.3 0.0 1.5 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 KOO25369.1 - 1.2e-19 70.8 5.6 1.2e-19 70.8 3.9 1.8 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal KIAA1430 PF13879.1 KOO25370.1 - 0.0025 18.1 0.0 0.0025 18.1 0.0 2.7 3 1 0 3 3 3 1 KIAA1430 homologue EF-hand_1 PF00036.27 KOO25370.1 - 0.0035 16.5 0.6 0.015 14.5 0.2 2.1 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO25370.1 - 0.035 14.0 0.1 0.21 11.5 0.1 2.2 2 0 0 2 2 2 0 EF-hand domain EF-hand_5 PF13202.1 KOO25370.1 - 0.081 12.3 0.3 0.25 10.7 0.2 1.8 1 0 0 1 1 1 0 EF hand LRR_4 PF12799.2 KOO25371.1 - 6.3e-15 54.4 1.4 3.6e-07 29.6 0.0 3.4 2 1 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO25371.1 - 7.4e-14 51.2 2.1 1.4e-07 31.1 0.1 2.6 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.28 KOO25371.1 - 2.4e-10 38.9 2.0 0.17 12.0 0.0 4.5 4 0 0 4 4 4 3 Leucine Rich Repeat LRR_7 PF13504.1 KOO25371.1 - 2.1e-09 36.0 6.7 0.68 10.3 0.2 4.9 4 0 0 4 4 4 4 Leucine rich repeat Miro PF08477.8 KOO25371.1 - 3.1e-05 24.4 0.0 6.2e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein Ras PF00071.17 KOO25371.1 - 0.0009 18.6 0.0 0.0017 17.7 0.0 1.5 1 1 0 1 1 1 1 Ras family G-alpha PF00503.15 KOO25371.1 - 0.11 11.1 0.0 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit LRR_6 PF13516.1 KOO25371.1 - 0.81 9.9 2.6 1.7e+02 2.7 0.0 4.0 4 0 0 4 4 4 0 Leucine Rich repeat WD40 PF00400.27 KOO25373.1 - 6.1e-12 44.9 24.2 1.2 9.1 0.0 10.8 11 0 0 11 11 11 6 WD domain, G-beta repeat Ion_trans PF00520.26 KOO25373.1 - 3.2e-07 29.8 17.3 1.6e-06 27.5 12.0 2.1 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.7 KOO25373.1 - 2.2e-05 23.0 16.6 0.013 13.9 9.0 2.3 2 0 0 2 2 2 2 Polycystin cation channel Ank_4 PF13637.1 KOO25373.1 - 0.00083 19.7 1.6 0.78 10.3 0.1 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO25373.1 - 0.001 19.3 0.5 0.0025 18.1 0.3 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO25373.1 - 0.022 14.9 1.2 0.45 10.8 0.7 2.7 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Herpes_capsid PF06112.6 KOO25373.1 - 4.5 7.3 11.9 12 5.9 8.3 1.7 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein DAGAT PF03982.8 KOO25374.1 - 1.9e-05 23.5 0.0 2.6e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Acyltransferase PF01553.16 KOO25374.1 - 0.00023 20.6 0.0 0.0041 16.5 0.0 2.2 1 1 0 1 1 1 1 Acyltransferase MDMPI_C PF07398.6 KOO25374.1 - 0.1 13.1 1.5 0.27 11.8 0.3 2.3 2 0 0 2 2 2 0 MDMPI C-terminal domain DUF3336 PF11815.3 KOO25375.1 - 3.4e-26 91.4 0.2 6.4e-26 90.6 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.17 KOO25375.1 - 4.4e-18 65.9 1.2 2.9e-16 60.0 0.0 3.1 3 0 0 3 3 3 1 Patatin-like phospholipase Phage_Coat_B PF05356.6 KOO25376.1 - 0.0061 16.2 0.1 0.012 15.3 0.1 1.5 1 0 0 1 1 1 1 Phage Coat protein B Pkinase PF00069.20 KOO25377.1 - 4.8e-57 193.0 0.0 7.2e-57 192.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25377.1 - 3.1e-27 95.2 0.0 4.8e-27 94.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1741 PF08427.5 KOO25377.1 - 2.9e-16 59.6 0.0 4.9e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) APH PF01636.18 KOO25377.1 - 1.6e-05 24.7 0.0 0.00026 20.8 0.0 3.9 3 2 1 4 4 4 2 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO25377.1 - 5.9e-05 22.1 0.0 9.6e-05 21.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 KOO25377.1 - 0.043 13.1 0.0 0.077 12.3 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Kelch_3 PF13415.1 KOO25378.1 - 7.7e-13 48.2 0.0 0.0016 18.5 0.0 5.1 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KOO25378.1 - 6.7e-10 38.5 7.9 0.062 13.0 0.0 5.5 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO25378.1 - 2.8e-08 33.5 4.0 0.073 13.0 0.0 5.0 5 0 0 5 5 5 3 Kelch motif EF-hand_1 PF00036.27 KOO25378.1 - 7.4e-08 31.1 0.1 0.00016 20.6 0.0 3.1 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO25378.1 - 1.1e-07 31.1 0.5 0.00026 20.6 0.0 3.7 2 1 1 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO25378.1 - 1.1e-07 31.8 0.0 4.3e-07 29.9 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO25378.1 - 8.1e-07 28.1 1.0 0.00078 18.6 0.0 3.0 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO25378.1 - 0.00078 19.0 0.1 0.0032 17.0 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain pair Kelch_6 PF13964.1 KOO25378.1 - 0.0011 19.0 0.0 2.8 8.2 0.0 4.2 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.10 KOO25378.1 - 0.26 11.1 2.0 0.69 9.7 0.0 2.9 4 0 0 4 4 4 0 Kelch motif SPX PF03105.14 KOO25378.1 - 9.7 5.8 5.3 5.5 6.6 0.4 2.4 2 0 0 2 2 2 0 SPX domain SPC12 PF06645.8 KOO25379.1 - 0.088 12.6 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Microsomal signal peptidase 12 kDa subunit (SPC12) EF-hand_9 PF14658.1 KOO25381.1 - 1.7e-05 24.6 0.0 0.04 13.8 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO25381.1 - 6.5e-05 22.9 0.0 0.35 11.0 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO25381.1 - 0.00036 20.1 0.0 0.18 11.7 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.27 KOO25381.1 - 0.023 13.9 0.0 8.8 5.8 0.0 2.7 3 0 0 3 3 3 0 EF hand EF-hand_8 PF13833.1 KOO25381.1 - 0.044 13.4 0.0 0.42 10.2 0.0 2.4 3 0 0 3 3 3 0 EF-hand domain pair zf-RING_2 PF13639.1 KOO25382.1 - 7.7e-12 44.8 12.5 1.2e-11 44.2 8.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KOO25382.1 - 1.9e-07 31.1 7.3 3.8e-07 30.1 5.0 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 KOO25382.1 - 3.1e-05 23.5 13.8 5.5e-05 22.7 9.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO25382.1 - 0.0041 16.7 12.8 0.0063 16.2 8.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 KOO25382.1 - 0.0043 17.0 13.9 0.0076 16.2 9.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 KOO25382.1 - 0.14 12.0 9.0 0.38 10.6 6.3 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.1 KOO25382.1 - 0.14 11.8 14.5 0.21 11.3 10.0 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Baculo_RING PF05883.6 KOO25382.1 - 0.15 11.8 2.9 0.24 11.2 2.0 1.2 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain FANCL_C PF11793.3 KOO25382.1 - 0.27 11.2 15.5 5.3 7.0 10.7 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain PHD PF00628.24 KOO25382.1 - 0.3 10.8 11.8 0.72 9.5 8.2 1.6 1 1 0 1 1 1 0 PHD-finger zf-HC5HC2H PF13771.1 KOO25382.1 - 0.48 10.6 10.2 0.041 14.0 3.5 1.7 1 1 0 2 2 2 0 PHD-like zinc-binding domain zf-RING-like PF08746.6 KOO25382.1 - 1.3 9.0 11.9 2.4 8.2 8.3 1.4 1 0 0 1 1 1 0 RING-like domain RINGv PF12906.2 KOO25382.1 - 2.7 8.1 14.9 4.2 7.4 10.4 1.3 1 0 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.1 KOO25382.1 - 2.7 7.6 11.1 4.4 6.9 7.7 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.1 KOO25382.1 - 6.5 6.6 8.5 13 5.6 5.9 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Prok-RING_1 PF14446.1 KOO25382.1 - 6.7 6.5 13.6 2.2e+02 1.6 9.1 2.1 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 EF-hand_1 PF00036.27 KOO25383.1 - 1.4e-30 102.2 21.6 4.6e-09 34.9 0.0 4.4 5 0 0 5 5 4 4 EF hand EF-hand_7 PF13499.1 KOO25383.1 - 7.5e-28 96.4 9.1 1.4e-15 57.1 0.3 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO25383.1 - 1.2e-25 88.8 11.3 2.9e-12 46.0 0.2 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO25383.1 - 1e-24 84.1 15.2 4.8e-09 35.3 0.0 5.3 4 2 2 6 6 6 4 EF-hand domain EF-hand_5 PF13202.1 KOO25383.1 - 1.7e-20 71.3 20.5 3.5e-06 26.1 0.2 5.0 5 1 0 5 5 4 4 EF hand EF-hand_9 PF14658.1 KOO25383.1 - 6.7e-13 48.3 0.1 4.5e-07 29.6 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 KOO25383.1 - 1.8e-06 27.6 3.8 0.15 11.8 0.6 3.6 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO25383.1 - 0.001 19.0 0.2 1.6 8.7 0.1 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region LETM1 PF07766.8 KOO25383.1 - 0.0097 14.9 0.2 0.013 14.5 0.1 1.3 1 0 0 1 1 1 1 LETM1-like protein Caleosin PF05042.8 KOO25383.1 - 0.013 15.0 0.1 5.5 6.5 0.0 2.5 2 1 0 2 2 2 0 Caleosin related protein DUF3008 PF11450.3 KOO25383.1 - 0.015 15.4 1.9 0.1 12.7 0.1 2.9 3 0 0 3 3 2 0 Protein of unknwon function (DUF3008) Toprim_2 PF13155.1 KOO25383.1 - 0.017 15.4 1.8 5.2 7.4 0.0 2.4 1 1 0 2 2 2 0 Toprim-like OST-HTH PF12872.2 KOO25383.1 - 0.037 13.8 0.0 15 5.4 0.0 3.3 3 1 1 4 4 4 0 OST-HTH/LOTUS domain Acetyltransf_11 PF13720.1 KOO25383.1 - 0.04 14.1 0.3 1.9 8.7 0.0 2.4 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 TerB PF05099.8 KOO25383.1 - 0.071 12.8 1.7 8.9 6.0 0.1 2.6 1 1 2 3 3 3 0 Tellurite resistance protein TerB TyeA PF09059.5 KOO25383.1 - 0.098 12.5 0.1 0.43 10.5 0.0 1.9 2 0 0 2 2 2 0 TyeA DUF21 PF01595.15 KOO25383.1 - 0.1 11.8 0.2 0.68 9.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF21 UPF0154 PF03672.8 KOO25383.1 - 0.13 11.9 0.6 10 5.8 0.0 3.3 4 0 0 4 4 4 0 Uncharacterised protein family (UPF0154) PMBR PF09373.5 KOO25383.1 - 0.13 12.2 0.2 19 5.4 0.0 4.2 6 0 0 6 6 6 0 Pseudomurein-binding repeat Endonuc-dimeris PF09124.5 KOO25383.1 - 0.23 11.1 3.6 4.1 7.1 0.0 2.9 3 0 0 3 3 3 0 T4 recombination endonuclease VII, dimerisation DUF4373 PF14297.1 KOO25383.1 - 0.29 11.4 2.4 58 4.0 0.1 3.5 1 1 3 4 4 4 0 Domain of unknown function (DUF4373) MgtE_N PF03448.12 KOO25383.1 - 0.33 11.3 2.5 0.62 10.4 0.1 2.3 2 1 0 2 2 2 0 MgtE intracellular N domain EF-hand_10 PF14788.1 KOO25383.1 - 0.69 9.6 3.3 9.6 5.9 0.3 2.8 2 1 1 3 3 3 0 EF hand Phage_GP20 PF06810.6 KOO25384.1 - 0.02 14.3 3.5 0.03 13.7 2.4 1.2 1 0 0 1 1 1 0 Phage minor structural protein GP20 Ribosomal_L29 PF00831.18 KOO25384.1 - 0.036 13.7 10.8 0.78 9.4 1.3 2.9 1 1 2 3 3 3 0 Ribosomal L29 protein Laminin_II PF06009.7 KOO25384.1 - 0.09 12.5 8.3 0.15 11.7 5.7 1.3 1 0 0 1 1 1 0 Laminin Domain II UDPGP PF01704.13 KOO25384.1 - 0.13 10.7 0.0 0.2 10.1 0.0 1.3 1 0 0 1 1 1 0 UTP--glucose-1-phosphate uridylyltransferase FlxA PF14282.1 KOO25384.1 - 0.17 11.8 7.4 0.3 11.0 5.1 1.4 1 0 0 1 1 1 0 FlxA-like protein DUF342 PF03961.8 KOO25384.1 - 0.23 9.8 5.1 0.11 10.8 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF342) NPV_P10 PF05531.7 KOO25384.1 - 3.2 8.0 6.4 17 5.7 4.3 2.1 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Sas10_Utp3 PF04000.10 KOO25384.1 - 3.7 7.8 6.0 56 4.0 4.2 2.3 1 1 0 1 1 1 0 Sas10/Utp3/C1D family Enkurin PF13864.1 KOO25384.1 - 6.6 7.0 9.0 2.9 8.1 4.5 1.8 2 1 0 2 2 2 0 Calmodulin-binding Glyco_transf_22 PF03901.12 KOO25385.1 - 1.9e-50 172.1 7.6 2.5e-50 171.7 5.3 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family CS PF04969.11 KOO25385.1 - 6.7e-07 29.7 0.0 1e-06 29.2 0.0 1.3 1 0 0 1 1 1 1 CS domain DUF4190 PF13828.1 KOO25385.1 - 0.089 12.3 0.0 0.089 12.3 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4190) Aminotran_1_2 PF00155.16 KOO25386.1 - 3.7e-62 210.3 0.0 4.3e-62 210.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 KOO25386.1 - 3.2e-07 29.4 0.0 5.5e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 KOO25386.1 - 3.9e-05 22.9 0.0 5.9e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 KOO25386.1 - 4.7e-05 22.5 0.0 0.0001 21.4 0.0 1.5 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.15 KOO25386.1 - 0.0012 17.1 0.0 0.0021 16.4 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme PDZ PF00595.19 KOO25387.1 - 0.0016 18.5 0.0 0.0023 18.0 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO25387.1 - 0.0099 15.7 0.0 0.027 14.3 0.0 1.7 1 1 1 2 2 2 1 PDZ domain FAT PF02259.18 KOO25388.1 - 6.1e-81 272.1 3.0 2.6e-80 270.0 0.2 3.0 2 1 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.22 KOO25388.1 - 4.2e-60 203.1 0.3 6.7e-60 202.4 0.2 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Rapamycin_bind PF08771.6 KOO25388.1 - 1.9e-37 127.3 3.5 1.9e-36 124.1 0.3 2.8 2 0 0 2 2 2 1 Rapamycin binding domain DUF3385 PF11865.3 KOO25388.1 - 3.5e-27 95.2 0.0 6.3e-24 84.7 0.0 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF3385) FATC PF02260.15 KOO25388.1 - 1.6e-12 46.5 2.4 1.7e-12 46.5 0.3 2.1 2 0 0 2 2 2 1 FATC domain HEAT_2 PF13646.1 KOO25388.1 - 1.8e-06 28.1 20.8 0.0045 17.2 0.3 6.1 4 2 1 5 5 5 4 HEAT repeats HEAT_EZ PF13513.1 KOO25388.1 - 0.00015 22.1 1.1 0.00015 22.1 0.8 9.1 7 2 4 11 11 9 2 HEAT-like repeat DUF2454 PF10521.4 KOO25388.1 - 0.008 15.2 1.6 0.11 11.4 0.0 3.1 2 1 2 4 4 4 1 Protein of unknown function (DUF2454) UME PF08064.8 KOO25388.1 - 0.0084 16.0 0.4 0.19 11.6 0.0 3.4 3 0 0 3 3 3 1 UME (NUC010) domain HEAT PF02985.17 KOO25388.1 - 0.028 14.4 13.7 1 9.6 0.1 6.7 7 0 0 7 7 7 0 HEAT repeat Adaptin_N PF01602.15 KOO25388.1 - 0.043 12.1 0.1 19 3.3 0.0 3.2 3 0 0 3 3 3 0 Adaptin N terminal region Arm_2 PF04826.8 KOO25388.1 - 0.25 10.4 0.0 0.56 9.2 0.0 1.5 1 0 0 1 1 1 0 Armadillo-like TAFII55_N PF04658.8 KOO25389.1 - 1.2e-17 63.9 0.0 1.9e-16 59.9 0.0 2.1 1 1 0 1 1 1 1 TAFII55 protein conserved region Ribosomal_L28e PF01778.12 KOO25390.1 - 5.1e-30 104.2 0.2 6.1e-30 104.0 0.1 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family RNase_H PF00075.19 KOO25391.1 - 5.2e-26 91.5 0.0 7.4e-26 91.0 0.0 1.1 1 0 0 1 1 1 1 RNase H Alpha-amylase PF00128.19 KOO25392.1 - 3.9e-11 42.9 0.0 3.2e-08 33.3 0.0 2.1 1 1 1 2 2 2 2 Alpha amylase, catalytic domain KOG2701 PF09762.4 KOO25393.1 - 4.2e-53 180.0 0.0 4.2e-53 180.0 0.0 3.9 3 1 0 5 5 5 1 Coiled-coil domain-containing protein (DUF2037) WD-3 PF09765.4 KOO25393.1 - 0.00017 21.0 1.5 0.00037 19.8 1.1 1.5 1 0 0 1 1 1 1 WD-repeat region Baculo_PEP_C PF04513.7 KOO25393.1 - 0.21 11.4 6.2 4 7.2 0.6 3.3 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus zf-ZPR1 PF03367.8 KOO25393.1 - 1.4 8.0 5.8 0.26 10.4 0.2 2.5 2 1 0 2 2 2 0 ZPR1 zinc-finger domain RRM_1 PF00076.17 KOO25395.1 - 1.4e-10 40.6 0.0 1.9e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO25395.1 - 6.1e-10 38.9 0.0 8.8e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 KOO25395.1 - 0.0018 17.9 0.0 0.0037 16.9 0.0 1.5 1 0 0 1 1 1 1 Limkain b1 RRM_5 PF13893.1 KOO25395.1 - 0.01 15.6 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_60s PF00428.14 KOO25395.1 - 0.69 10.3 7.2 0.2 12.0 1.7 2.4 3 0 0 3 3 3 0 60s Acidic ribosomal protein CENP-B_dimeris PF09026.5 KOO25395.1 - 0.88 9.8 6.0 3.6 7.8 2.7 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain PBP1_TM PF14812.1 KOO25395.1 - 4.4 7.6 6.2 0.59 10.4 0.8 2.1 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PBP_like_2 PF12849.2 KOO25396.1 - 2.3e-48 165.0 0.8 3.3e-48 164.5 0.5 1.2 1 0 0 1 1 1 1 PBP superfamily domain TFIIB PF00382.14 KOO25396.1 - 0.052 13.3 0.0 0.19 11.5 0.0 1.9 1 0 0 1 1 1 0 Transcription factor TFIIB repeat RVT_3 PF13456.1 KOO25398.1 - 7.5e-15 54.4 0.0 1.1e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase-like His_Phos_1 PF00300.17 KOO25398.1 - 7.6e-13 48.8 0.0 1.3e-12 48.1 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) HlyIII PF03006.15 KOO25400.1 - 3.4e-17 62.6 16.8 4.1e-17 62.3 11.7 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF808 PF05661.7 KOO25400.1 - 0.05 12.4 4.4 0.026 13.3 1.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF808) UPF0182 PF03699.8 KOO25400.1 - 5.8 4.7 5.7 7.5 4.3 3.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Gly_transf_sug PF04488.10 KOO25401.1 - 3.9e-08 33.6 0.0 8.6e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 KOO25401.1 - 0.00023 19.7 3.0 0.015 13.7 0.2 2.1 2 0 0 2 2 2 2 TcdA/TcdB catalytic glycosyltransferase domain Podoplanin PF05808.6 KOO25402.1 - 4.2 6.9 7.6 6.1 6.3 5.2 1.3 1 0 0 1 1 1 0 Podoplanin EF-hand_7 PF13499.1 KOO25404.1 - 3e-28 97.7 3.6 1.1e-18 67.0 0.6 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO25404.1 - 8.9e-27 90.3 13.3 1.1e-08 33.7 0.3 4.2 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.1 KOO25404.1 - 1.3e-21 74.4 7.5 2.7e-08 33.0 0.1 3.7 2 1 1 3 3 3 3 EF-hand domain EF-hand_5 PF13202.1 KOO25404.1 - 2.6e-21 73.9 8.7 5e-07 28.7 0.2 3.6 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 KOO25404.1 - 2.2e-17 62.3 13.2 3.6e-08 32.9 0.0 4.3 1 1 3 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO25404.1 - 0.00031 20.7 0.0 0.071 13.1 0.0 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO25404.1 - 0.062 13.0 1.4 0.58 9.9 0.1 2.7 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO25404.1 - 0.085 12.5 1.7 19 4.9 0.0 3.2 3 0 0 3 3 3 0 EF hand DnaJ PF00226.26 KOO25405.1 - 5.3e-09 35.6 0.1 1.1e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain eIF-5_eIF-2B PF01873.12 KOO25406.1 - 5.9e-41 139.0 0.0 8.5e-41 138.5 0.0 1.2 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Lar_restr_allev PF14354.1 KOO25406.1 - 0.062 13.6 0.6 0.31 11.3 0.4 2.3 1 1 0 1 1 1 0 Restriction alleviation protein Lar Zn-ribbon_8 PF09723.5 KOO25406.1 - 0.14 12.1 0.8 0.28 11.1 0.5 1.5 1 0 0 1 1 1 0 Zinc ribbon domain Totivirus_coat PF05518.6 KOO25406.1 - 4.5 4.9 5.1 6.1 4.5 3.5 1.1 1 0 0 1 1 1 0 Totivirus coat protein Arc_trans_TRASH PF08394.5 KOO25406.1 - 5 7.3 5.6 2.1 8.5 0.2 2.3 1 1 1 2 2 2 0 Archaeal TRASH domain Arm PF00514.18 KOO25408.1 - 2.9e-231 740.6 208.7 9.8e-09 34.7 0.8 66.3 68 0 0 68 68 68 46 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO25408.1 - 1.3e-33 115.1 215.6 3.2e-06 27.3 0.1 27.8 14 7 16 31 31 31 20 HEAT repeats Arm_2 PF04826.8 KOO25408.1 - 1.5e-25 89.7 31.1 0.013 14.6 0.0 19.3 14 6 7 22 22 22 8 Armadillo-like V-ATPase_H_N PF03224.9 KOO25408.1 - 1.5e-22 80.1 1.9 0.0014 17.7 0.0 14.0 5 4 3 10 10 10 3 V-ATPase subunit H Atx10homo_assoc PF09759.4 KOO25408.1 - 7.1e-11 41.7 20.0 0.025 14.3 0.2 11.2 10 2 1 11 11 9 2 Spinocerebellar ataxia type 10 protein domain Adaptin_N PF01602.15 KOO25408.1 - 2.1e-09 36.2 22.2 0.051 11.8 0.5 10.2 10 2 1 11 11 11 4 Adaptin N terminal region EF-hand_1 PF00036.27 KOO25408.1 - 1.6e-07 30.0 4.1 0.00079 18.5 0.1 3.2 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO25408.1 - 1.7e-07 30.7 0.5 7.8e-07 28.6 0.2 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.1 KOO25408.1 - 1e-06 28.7 1.9 2.6e-06 27.4 1.0 2.0 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO25408.1 - 2.4e-06 26.9 3.0 0.0017 18.0 0.1 3.2 3 0 0 3 3 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO25408.1 - 0.0074 15.5 7.3 0.032 13.5 0.2 3.6 4 0 0 4 4 4 1 EF hand V-ATPase_H_C PF11698.3 KOO25408.1 - 0.019 14.8 12.4 7.3 6.5 0.0 7.1 10 0 0 10 10 7 0 V-ATPase subunit H KAP PF05804.7 KOO25408.1 - 0.042 11.7 0.0 24 2.6 0.0 4.7 5 1 0 5 5 5 0 Kinesin-associated protein (KAP) DRIM PF07539.7 KOO25408.1 - 0.1 12.0 1.5 12 5.3 0.0 5.0 6 0 0 6 6 6 0 Down-regulated in metastasis N1221 PF07923.8 KOO25408.1 - 2.2 7.0 15.3 54 2.5 0.0 7.8 8 1 0 9 9 9 0 N1221-like protein DUF2262 PF10020.4 KOO25408.1 - 3.7 7.7 8.4 2.6 8.2 0.5 4.0 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2262) RdRP PF05183.7 KOO25409.1 - 7e-50 170.2 0.0 1.4e-49 169.2 0.0 1.4 1 0 0 1 1 1 1 RNA dependent RNA polymerase DEAD PF00270.24 KOO25409.1 - 7.8e-18 64.5 0.9 9.5e-16 57.7 0.2 2.6 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO25409.1 - 2.1e-11 43.5 0.0 5.9e-11 42.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO25409.1 - 1.9e-08 34.3 0.1 1.9e-08 34.3 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit MBD PF01429.14 KOO25409.1 - 2.1e-08 33.5 0.0 5.4e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 Methyl-CpG binding domain Chromo PF00385.19 KOO25409.1 - 7.3e-06 25.5 0.1 1.6e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Pkinase PF00069.20 KOO25410.1 - 6.8e-58 195.8 0.0 9.4e-58 195.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25410.1 - 1.3e-38 132.5 0.0 1.8e-38 132.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO25410.1 - 9.4e-05 21.5 0.0 0.00022 20.2 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Pkinase PF00069.20 KOO25412.1 - 5e-47 160.2 0.0 6.9e-47 159.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25412.1 - 1.2e-14 54.0 0.0 1.9e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase ACT PF01842.20 KOO25412.1 - 2.7e-07 29.9 0.3 0.00012 21.5 0.1 2.6 2 0 0 2 2 2 2 ACT domain ACT_4 PF13291.1 KOO25412.1 - 0.0055 17.0 0.2 1.5 9.1 0.0 3.0 3 0 0 3 3 3 1 ACT domain ACT_6 PF13740.1 KOO25412.1 - 0.078 12.6 0.5 0.86 9.3 0.1 2.7 2 0 0 2 2 2 0 ACT domain TSC22 PF01166.13 KOO25412.1 - 0.13 12.2 0.5 0.41 10.6 0.3 1.8 1 0 0 1 1 1 0 TSC-22/dip/bun family HALZ PF02183.13 KOO25412.1 - 0.19 11.4 3.3 0.58 9.9 0.2 2.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF972 PF06156.8 KOO25412.1 - 0.4 11.0 0.1 0.83 10.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) APH PF01636.18 KOO25412.1 - 1.5 8.4 17.3 1.4 8.5 0.0 4.6 2 1 2 4 4 4 0 Phosphotransferase enzyme family Aldedh PF00171.17 KOO25413.1 - 2.6e-05 22.7 0.1 0.015 13.6 0.0 2.1 2 0 0 2 2 2 2 Aldehyde dehydrogenase family Acetyltransf_1 PF00583.19 KOO25413.1 - 0.097 12.7 0.0 0.34 10.9 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family AA_kinase PF00696.23 KOO25414.1 - 1e-23 84.1 0.3 1.2e-23 83.9 0.2 1.0 1 0 0 1 1 1 1 Amino acid kinase family Abhydrolase_5 PF12695.2 KOO25415.1 - 4.3e-10 39.5 0.0 6.5e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO25415.1 - 4.2e-07 30.0 3.1 5.1e-05 23.2 2.0 2.2 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO25415.1 - 0.011 15.2 0.0 0.016 14.7 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_8 PF06259.7 KOO25415.1 - 0.018 14.5 0.0 0.038 13.4 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase DLH PF01738.13 KOO25415.1 - 0.048 12.9 0.0 0.093 12.0 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family Acyl-CoA_dh_1 PF00441.19 KOO25416.1 - 5.1e-20 72.1 1.7 7.9e-19 68.2 0.5 2.9 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 KOO25416.1 - 7.3e-19 68.4 0.0 1.6e-18 67.2 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_C PF12806.2 KOO25416.1 - 8.7e-18 64.4 0.6 1.9e-17 63.3 0.4 1.6 1 0 0 1 1 1 1 Acetyl-CoA dehydrogenase C-terminal like Acyl-CoA_dh_M PF02770.14 KOO25416.1 - 4.3e-16 58.1 0.1 5.9e-15 54.5 0.0 2.8 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, middle domain AcylCoA_DH_N PF12418.3 KOO25416.1 - 2.9e-07 30.0 0.1 5.6e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase N terminal Acyl-CoA_dh_2 PF08028.6 KOO25416.1 - 3.6e-05 24.0 0.6 0.00057 20.1 0.0 2.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Neur_chan_LBD PF02931.18 KOO25417.1 - 0.0019 17.3 2.0 0.0029 16.7 0.6 2.1 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain adh_short PF00106.20 KOO25418.1 - 1.8e-18 67.0 2.6 3.4e-18 66.1 1.7 1.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KOO25418.1 - 2.5e-18 66.7 0.1 1.3e-17 64.4 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KOO25418.1 - 1.2e-06 28.2 0.2 2.7e-06 27.1 0.2 1.5 1 0 0 1 1 1 1 KR domain Methyltransf_26 PF13659.1 KOO25418.1 - 0.029 14.3 1.4 0.049 13.6 1.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain AdoHcyase_NAD PF00670.16 KOO25418.1 - 0.047 13.5 0.9 0.081 12.7 0.4 1.5 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 3HCDH_N PF02737.13 KOO25418.1 - 0.13 11.9 0.5 0.25 10.9 0.3 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UVR PF02151.14 KOO25419.1 - 3.2e-09 35.9 13.4 0.00023 20.5 0.7 4.0 3 1 1 4 4 4 2 UvrB/uvrC motif PhoU_div PF01865.11 KOO25419.1 - 0.015 14.4 7.4 3.3 6.8 0.9 3.1 1 1 2 3 3 3 0 Protein of unknown function DUF47 DUF1090 PF06476.7 KOO25419.1 - 0.032 13.9 7.5 0.43 10.2 0.5 3.0 1 1 1 3 3 3 0 Protein of unknown function (DUF1090) RVT_N PF13655.1 KOO25419.1 - 0.069 13.2 0.5 1.8 8.7 0.1 2.5 2 1 0 2 2 2 0 N-terminal domain of reverse transcriptase Es2 PF09751.4 KOO25419.1 - 0.12 11.7 0.4 0.63 9.4 0.3 2.0 1 1 0 1 1 1 0 Nuclear protein Es2 Lipoprotein_11 PF03260.8 KOO25419.1 - 0.14 11.1 5.4 4.7 6.1 0.3 3.0 1 1 2 3 3 3 0 Lepidopteran low molecular weight (30 kD) lipoprotein Laps PF10169.4 KOO25419.1 - 8.1 6.6 7.1 27 4.9 4.2 2.1 1 1 1 2 2 2 0 Learning-associated protein FKBP_C PF00254.23 KOO25420.1 - 1.3e-18 66.7 0.0 1.9e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_7 PF13499.1 KOO25420.1 - 2.1e-08 34.1 0.6 3.4e-08 33.4 0.4 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO25420.1 - 6.9e-07 28.1 2.1 0.00095 18.3 0.3 2.4 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO25420.1 - 5.6e-06 25.4 0.7 0.00066 18.9 0.3 2.4 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.1 KOO25420.1 - 1.8e-05 24.2 3.0 0.00014 21.4 0.6 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO25420.1 - 8.9e-05 22.0 0.7 0.096 12.6 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain RVT_2 PF07727.9 KOO25421.1 - 3.1e-35 121.3 0.0 4.8e-35 120.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KOO25421.1 - 5.9e-15 55.4 0.1 1.8e-14 53.8 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain PABP PF00658.13 KOO25421.1 - 0.13 11.9 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 Poly-adenylate binding protein, unique domain DUF1125 PF06563.6 KOO25422.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1125) UBN2_2 PF14227.1 KOO25423.1 - 0.031 13.8 0.1 30 4.2 0.0 3.0 3 0 0 3 3 3 0 gag-polypeptide of LTR copia-type PEX11 PF05648.9 KOO25424.1 - 4.5e-10 39.1 3.1 2e-09 37.0 1.6 1.9 2 0 0 2 2 2 1 Peroxisomal biogenesis factor 11 (PEX11) Chitin_synth_2 PF03142.10 KOO25424.1 - 0.048 12.0 0.1 0.06 11.7 0.1 1.1 1 0 0 1 1 1 0 Chitin synthase Cons_hypoth698 PF03601.9 KOO25424.1 - 5 5.6 9.3 0.86 8.1 3.1 2.0 2 1 1 3 3 3 0 Conserved hypothetical protein 698 Snf7 PF03357.16 KOO25425.1 - 2.4e-19 69.3 9.4 2.5e-19 69.3 6.0 1.4 1 1 1 2 2 2 1 Snf7 TPR_5 PF12688.2 KOO25425.1 - 0.058 13.4 0.2 0.12 12.4 0.1 1.5 1 0 0 1 1 1 0 Tetratrico peptide repeat HAP PF03866.8 KOO25425.1 - 0.064 13.0 0.8 0.093 12.5 0.6 1.3 1 0 0 1 1 1 0 Hydrophobic abundant protein (HAP) Ist1 PF03398.9 KOO25425.1 - 0.067 12.5 1.0 0.093 12.1 0.7 1.3 1 1 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway GrpE PF01025.14 KOO25425.1 - 0.11 11.9 4.2 0.21 11.1 2.9 1.4 1 1 0 1 1 1 0 GrpE Fib_alpha PF08702.5 KOO25425.1 - 4.2 7.4 5.3 6.1 6.9 0.1 2.1 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Glyco_hydro_2_C PF02836.12 KOO25427.1 - 2.9e-25 88.7 0.0 7e-25 87.5 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.13 KOO25427.1 - 3.2e-12 46.3 0.0 6.4e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.16 KOO25427.1 - 0.01 16.2 0.0 0.025 14.9 0.0 1.7 2 0 0 2 2 2 0 Glycosyl hydrolases family 2 Paramyxo_PCT PF14320.1 KOO25427.1 - 0.023 13.6 0.2 0.045 12.6 0.1 1.4 1 0 0 1 1 1 0 Phosphoprotein P region PCT disordered Cupin_8 PF13621.1 KOO25428.1 - 2.2e-16 60.1 0.0 2.9e-16 59.7 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.17 KOO25428.1 - 1.7e-05 25.0 0.0 3e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_4 PF08007.7 KOO25428.1 - 0.024 13.9 0.0 0.04 13.1 0.0 1.3 1 0 0 1 1 1 0 Cupin superfamily protein ADK PF00406.17 KOO25429.1 - 2.9e-53 179.8 0.0 3.4e-53 179.5 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 KOO25429.1 - 1.3e-10 40.7 0.1 1e-05 25.0 0.0 2.5 2 0 0 2 2 2 2 Adenylate kinase, active site lid AAA_33 PF13671.1 KOO25429.1 - 4.3e-07 29.9 0.0 5.3e-07 29.5 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO25429.1 - 0.00013 22.7 0.0 0.00023 21.9 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOO25429.1 - 0.0028 17.9 0.0 0.0072 16.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOO25429.1 - 0.0062 15.6 0.0 0.01 14.9 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA PF00004.24 KOO25429.1 - 0.026 14.7 0.1 0.046 13.9 0.1 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Abhydrolase_1 PF00561.15 KOO25429.1 - 0.063 12.8 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Mg_chelatase PF01078.16 KOO25429.1 - 0.12 11.5 0.3 0.17 11.0 0.2 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ABC1 PF03109.11 KOO25430.1 - 2.8e-27 95.0 0.0 6.1e-27 93.9 0.0 1.5 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.17 KOO25430.1 - 3e-07 29.9 0.0 5.4e-06 25.8 0.0 2.3 2 0 0 2 2 2 1 RIO1 family APH PF01636.18 KOO25430.1 - 4e-06 26.7 0.0 7.6e-05 22.5 0.0 2.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family POTRA_2 PF08479.6 KOO25430.1 - 0.0067 16.0 0.0 0.067 12.8 0.0 2.2 2 0 0 2 2 2 1 POTRA domain, ShlB-type Asparaginase_II PF06089.7 KOO25430.1 - 0.078 11.6 0.1 0.13 10.8 0.1 1.3 1 0 0 1 1 1 0 L-asparaginase II DUF2648 PF10855.3 KOO25431.1 - 0.011 15.1 0.4 0.023 14.1 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2648) PX PF00787.19 KOO25432.1 - 1.4e-12 47.3 0.0 2.4e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 PX domain Cyclin_N PF00134.18 KOO25432.1 - 0.018 14.6 0.0 0.036 13.6 0.0 1.4 1 0 0 1 1 1 0 Cyclin, N-terminal domain Pkinase PF00069.20 KOO25433.1 - 4.5e-64 216.0 0.0 6e-64 215.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25433.1 - 5.8e-50 169.7 0.0 7.6e-50 169.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO25433.1 - 1e-05 24.6 0.0 8e-05 21.7 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 KOO25433.1 - 0.0052 16.5 0.1 0.093 12.4 0.0 2.5 2 1 1 3 3 3 1 Phosphotransferase enzyme family Nic96 PF04097.9 KOO25434.1 - 2e-27 95.6 0.0 3.7e-26 91.4 0.0 2.0 2 0 0 2 2 2 2 Nup93/Nic96 Ubie_methyltran PF01209.13 KOO25435.1 - 0.043 12.9 0.0 0.043 12.9 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family zf-RING_2 PF13639.1 KOO25436.1 - 3.5e-11 42.7 8.6 6e-11 41.9 6.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 KOO25436.1 - 4.9e-11 42.1 5.8 8.6e-11 41.3 4.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO25436.1 - 9.5e-11 41.5 8.4 1.6e-10 40.8 5.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO25436.1 - 6.8e-09 35.3 8.0 1.2e-08 34.5 5.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 KOO25436.1 - 2.3e-08 33.5 8.3 4.3e-08 32.6 5.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 KOO25436.1 - 2.8e-08 33.3 4.7 3.1e-08 33.2 2.0 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.2 KOO25436.1 - 1.2e-05 25.3 2.2 1.2e-05 25.3 1.6 1.7 2 0 0 2 2 1 1 RING-H2 zinc finger zf-C3HC4_4 PF15227.1 KOO25436.1 - 1.7e-05 24.5 8.7 3.3e-05 23.6 6.0 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING U-box PF04564.10 KOO25436.1 - 1.7e-05 24.6 0.0 4.7e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 U-box domain zf-RING_4 PF14570.1 KOO25436.1 - 0.00017 21.0 6.7 0.00031 20.2 4.6 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-Apc11 PF12861.2 KOO25436.1 - 0.0025 17.6 3.0 0.0048 16.7 2.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger DUF1409 PF07197.7 KOO25436.1 - 0.019 15.0 4.3 0.059 13.4 3.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1409) zf-Di19 PF05605.7 KOO25436.1 - 0.033 14.2 3.5 1.7 8.7 1.3 2.9 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-Nse PF11789.3 KOO25436.1 - 0.11 12.0 4.1 0.23 10.9 2.9 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.1 KOO25436.1 - 0.2 11.4 4.0 2.9 7.7 2.7 2.2 1 1 1 2 2 2 0 zf-RING of BARD1-type protein FANCL_C PF11793.3 KOO25436.1 - 0.46 10.4 5.5 4.3 7.3 3.8 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain TerY-C PF15616.1 KOO25436.1 - 0.47 10.3 4.0 0.39 10.6 1.4 1.9 2 0 0 2 2 2 0 TerY-C metal binding domain Prok-RING_4 PF14447.1 KOO25436.1 - 2.4 7.7 11.7 0.46 10.0 2.3 2.9 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 DZR PF12773.2 KOO25436.1 - 3.7 7.4 8.2 30 4.5 5.7 2.3 1 1 0 1 1 1 0 Double zinc ribbon Ras PF00071.17 KOO25438.1 - 7.6e-34 116.4 0.0 1.4e-33 115.5 0.0 1.4 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO25438.1 - 3.9e-15 56.3 0.0 7.8e-15 55.4 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein AAA_16 PF13191.1 KOO25438.1 - 1.1e-05 25.5 2.1 0.00073 19.5 0.0 3.2 3 0 0 3 3 3 1 AAA ATPase domain Arf PF00025.16 KOO25438.1 - 1.8e-05 24.0 0.0 3.1e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family NACHT PF05729.7 KOO25438.1 - 0.0098 15.5 0.0 0.065 12.8 0.0 2.2 3 0 0 3 3 3 1 NACHT domain MMR_HSR1 PF01926.18 KOO25438.1 - 0.025 14.5 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.1 KOO25438.1 - 0.055 13.6 0.0 0.13 12.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.11 KOO25438.1 - 0.14 11.3 0.0 0.25 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 TMF_DNA_bd PF12329.3 KOO25439.1 - 0.022 14.5 1.5 0.46 10.3 0.0 2.5 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Pox_A_type_inc PF04508.7 KOO25439.1 - 0.034 13.9 0.1 0.034 13.9 0.1 2.5 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat DUF4164 PF13747.1 KOO25439.1 - 0.036 14.1 0.2 0.072 13.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) FlxA PF14282.1 KOO25439.1 - 0.038 13.9 2.0 0.083 12.8 0.7 1.8 1 1 0 1 1 1 0 FlxA-like protein DUF3138 PF11336.3 KOO25439.1 - 0.044 11.9 0.2 0.047 11.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DivIC PF04977.10 KOO25439.1 - 0.061 12.8 0.6 1.2 8.6 0.1 2.2 2 0 0 2 2 2 0 Septum formation initiator SlyX PF04102.7 KOO25439.1 - 0.084 13.2 1.2 0.37 11.1 0.1 2.1 2 0 0 2 2 2 0 SlyX DUF3373 PF11853.3 KOO25439.1 - 0.13 10.8 0.1 0.15 10.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) FliJ PF02050.11 KOO25439.1 - 0.14 12.2 1.4 0.22 11.5 1.0 1.3 1 0 0 1 1 1 0 Flagellar FliJ protein DUF2937 PF11157.3 KOO25439.1 - 0.18 11.1 2.4 2.2 7.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) DUF4200 PF13863.1 KOO25439.1 - 0.19 11.7 2.4 0.63 10.0 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) MerR-DNA-bind PF09278.6 KOO25439.1 - 3.9 7.9 5.7 6.7 7.1 1.4 2.3 1 1 1 2 2 2 0 MerR, DNA binding DUF4124 PF13511.1 KOO25440.1 - 0.25 11.4 2.6 1.6 8.8 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4124) TPR_12 PF13424.1 KOO25441.1 - 2.4e-27 94.6 41.7 2.4e-09 36.9 1.5 6.5 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.1 KOO25441.1 - 4.7e-09 35.8 48.9 2e-05 24.3 0.3 8.8 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_2 PF07719.12 KOO25441.1 - 1.1 9.3 0.0 1.1 9.3 0.0 7.5 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO25441.1 - 1.1 9.1 16.6 3.4 7.7 0.1 6.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOO25441.1 - 1.6 8.4 12.8 21 4.9 0.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat Pkinase PF00069.20 KOO25442.1 - 2.6e-45 154.6 0.0 3.5e-45 154.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25442.1 - 2.1e-43 148.3 0.0 1.3e-42 145.6 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO25442.1 - 0.0044 16.0 0.0 0.0071 15.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO25442.1 - 0.019 14.7 0.3 0.059 13.0 0.1 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 KOO25442.1 - 0.1 11.6 0.2 0.2 10.6 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4266 PF14086.1 KOO25443.1 - 0.0061 17.0 1.7 0.45 11.0 0.2 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4266) ATX_III PF08098.6 KOO25443.1 - 9.1 6.2 10.0 12 5.7 0.4 2.7 3 0 0 3 3 3 0 Anemonia sulcata toxin III family Chorein_N PF12624.2 KOO25445.1 - 3.8e-07 29.6 0.0 2.4e-06 27.1 0.0 2.2 2 0 0 2 2 2 1 N-terminal region of Chorein, a TM vesicle-mediated sorter PaaX PF07848.7 KOO25445.1 - 0.016 15.2 0.0 0.057 13.4 0.0 1.9 1 0 0 1 1 1 0 PaaX-like protein Nitroreductase PF00881.19 KOO25445.1 - 0.033 14.0 0.2 0.068 12.9 0.1 1.4 1 0 0 1 1 1 0 Nitroreductase family ELM2 PF01448.19 KOO25447.1 - 0.12 12.9 0.3 0.26 11.9 0.0 1.7 2 0 0 2 2 2 0 ELM2 domain Abhydrolase_6 PF12697.2 KOO25448.1 - 2.2e-10 40.8 6.5 7.6e-10 39.0 3.9 2.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO25448.1 - 9.9e-08 31.8 0.0 4.3e-07 29.7 0.0 2.1 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO25448.1 - 0.00014 21.5 0.0 0.00057 19.5 0.1 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 KOO25448.1 - 0.023 14.5 0.0 0.061 13.1 0.0 1.7 1 0 0 1 1 1 0 Putative lysophospholipase Sulfate_transp PF00916.15 KOO25449.1 - 1.7e-27 96.1 26.6 1.6e-16 60.1 2.8 3.6 3 1 0 3 3 3 2 Sulfate transporter family Sulfate_tra_GLY PF13792.1 KOO25449.1 - 4.8e-09 35.7 7.4 4.8e-09 35.7 5.1 3.4 3 1 0 3 3 3 1 Sulfate transporter N-terminal domain with GLY motif Glucosamine_iso PF01182.15 KOO25450.1 - 2.4e-26 92.6 0.0 4.1e-26 91.9 0.0 1.4 1 1 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase AICARFT_IMPCHas PF01808.13 KOO25451.1 - 1.3e-87 293.7 0.0 1.8e-87 293.4 0.0 1.1 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.17 KOO25451.1 - 2.7e-25 88.1 0.0 4.8e-25 87.3 0.0 1.4 1 0 0 1 1 1 1 MGS-like domain Exo_endo_phos PF03372.18 KOO25453.1 - 8.5e-07 29.1 0.1 1.1e-06 28.7 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF221 PF02714.10 KOO25454.1 - 3.3e-08 32.7 9.3 6.6e-08 31.7 1.0 2.5 2 0 0 2 2 2 2 Domain of unknown function DUF221 Proteasome PF00227.21 KOO25455.1 - 1e-50 171.6 0.3 1.2e-50 171.4 0.2 1.0 1 0 0 1 1 1 1 Proteasome subunit NHL PF01436.16 KOO25456.1 - 1.6e-39 131.8 15.8 2e-07 30.6 0.0 6.9 6 1 0 6 6 6 6 NHL repeat BACK PF07707.10 KOO25456.1 - 2.2e-16 59.5 0.1 3.3e-16 59.0 0.1 1.2 1 0 0 1 1 1 1 BTB And C-terminal Kelch SGL PF08450.7 KOO25456.1 - 4.8e-12 45.7 0.0 0.00061 19.2 0.0 3.7 1 1 3 4 4 4 4 SMP-30/Gluconolaconase/LRE-like region Arylesterase PF01731.15 KOO25456.1 - 3.3e-06 26.9 0.0 0.13 12.2 0.0 4.1 4 0 0 4 4 4 1 Arylesterase PQQ_3 PF13570.1 KOO25456.1 - 1.5e-05 25.0 4.3 0.59 10.4 0.0 5.5 6 0 0 6 6 6 2 PQQ-like domain Str_synth PF03088.11 KOO25456.1 - 0.00013 21.9 0.0 5 7.2 0.0 4.1 4 1 0 4 4 4 2 Strictosidine synthase DUF839 PF05787.8 KOO25456.1 - 0.00015 20.8 0.7 3.9 6.2 0.1 3.8 1 1 1 3 3 3 2 Bacterial protein of unknown function (DUF839) Lactonase PF10282.4 KOO25456.1 - 0.00028 20.0 0.0 0.011 14.8 0.0 2.8 1 1 3 4 4 4 3 Lactonase, 7-bladed beta-propeller PQQ_2 PF13360.1 KOO25456.1 - 0.00057 19.4 0.0 0.076 12.4 0.0 3.1 2 1 1 3 3 3 1 PQQ-like domain MoeA_C PF03454.10 KOO25456.1 - 0.13 12.1 0.6 1.2 9.0 0.0 2.8 3 1 1 4 4 3 0 MoeA C-terminal region (domain IV) Colipase-like PF15083.1 KOO25456.1 - 0.31 11.0 3.4 1.1 9.2 1.1 2.1 2 0 0 2 2 2 0 Colipase-like Filamin PF00630.14 KOO25457.1 - 1.9e-90 297.9 0.0 8.7e-14 51.9 0.0 9.2 8 1 1 9 9 9 9 Filamin/ABP280 repeat YtkA PF13115.1 KOO25457.1 - 0.00017 21.8 0.0 8.4 6.8 0.0 4.6 4 0 0 4 4 4 1 YtkA-like Big_3_4 PF13754.1 KOO25457.1 - 1.6 9.1 19.1 3.8 7.8 0.4 7.4 7 0 0 7 7 7 0 Bacterial Ig-like domain (group 3) ABC_tran PF00005.22 KOO25458.1 - 1.5e-08 35.0 0.0 3.3e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_28 PF13521.1 KOO25458.1 - 4.3e-05 23.5 0.7 0.00043 20.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 KOO25458.1 - 0.0025 17.2 0.0 0.0058 16.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_17 PF13207.1 KOO25458.1 - 0.0041 17.9 0.1 0.14 13.0 0.0 2.3 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.18 KOO25458.1 - 0.006 16.5 0.0 0.017 15.1 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase ArgK PF03308.11 KOO25458.1 - 0.012 14.4 0.5 0.84 8.3 0.1 2.2 2 0 0 2 2 2 0 ArgK protein NACHT PF05729.7 KOO25458.1 - 0.029 14.0 0.0 0.059 13.0 0.0 1.5 1 0 0 1 1 1 0 NACHT domain DUF258 PF03193.11 KOO25458.1 - 0.039 13.1 0.0 0.072 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_25 PF13481.1 KOO25458.1 - 0.039 13.3 0.0 0.16 11.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.1 KOO25458.1 - 0.04 13.8 0.0 0.063 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF2383 PF09537.5 KOO25458.1 - 0.054 13.7 1.6 0.18 12.0 1.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) AAA_23 PF13476.1 KOO25458.1 - 0.059 13.6 0.0 0.19 12.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain Miro PF08477.8 KOO25458.1 - 0.088 13.3 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein AAA_16 PF13191.1 KOO25458.1 - 0.24 11.3 2.0 2.2 8.2 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.22 KOO25459.1 - 1.4e-32 112.8 0.7 1.5e-20 73.8 0.0 3.2 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.1 KOO25459.1 - 1.8e-09 38.0 0.0 0.0067 16.4 0.0 3.2 3 0 0 3 3 3 3 AAA domain SMC_N PF02463.14 KOO25459.1 - 1.2e-05 24.6 0.0 0.00091 18.5 0.0 2.9 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 KOO25459.1 - 0.00016 22.0 1.3 0.4 10.9 0.2 2.1 2 0 0 2 2 2 2 AAA domain ABC_tran_2 PF12848.2 KOO25459.1 - 0.00044 20.0 7.9 0.0012 18.6 5.5 1.7 1 1 0 1 1 1 1 ABC transporter SbcCD_C PF13558.1 KOO25459.1 - 0.0029 17.4 0.2 0.34 10.8 0.0 3.1 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.1 KOO25459.1 - 0.0032 17.6 0.2 0.022 14.8 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KOO25459.1 - 0.0041 17.1 1.2 0.013 15.4 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.1 KOO25459.1 - 0.012 15.1 0.0 0.025 14.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.7 KOO25459.1 - 0.013 15.1 0.0 0.024 14.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain UPF0079 PF02367.12 KOO25459.1 - 0.032 13.8 0.0 0.086 12.4 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 DUF258 PF03193.11 KOO25459.1 - 0.051 12.7 0.1 0.12 11.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_5 PF07728.9 KOO25459.1 - 0.088 12.5 0.2 1.4 8.6 0.1 2.7 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Miro PF08477.8 KOO25459.1 - 0.096 13.1 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein Pkinase PF00069.20 KOO25461.1 - 1.8e-17 63.3 0.0 3.1e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25461.1 - 3.8e-08 32.7 0.0 1.1e-07 31.1 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.2 KOO25462.1 - 2.9e-110 360.8 37.9 4.1e-16 59.0 0.4 7.7 2 1 9 11 11 11 10 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO25462.1 - 6e-52 173.1 4.4 2.4e-08 34.2 0.0 10.7 5 3 6 11 11 11 10 Ankyrin repeats (many copies) Ank PF00023.25 KOO25462.1 - 3.8e-47 155.8 21.7 0.00021 20.9 0.0 14.6 15 0 0 15 15 15 11 Ankyrin repeat Ank_5 PF13857.1 KOO25462.1 - 5.4e-35 118.6 21.8 3.1e-05 24.0 0.0 11.3 8 3 5 13 13 13 8 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO25462.1 - 8.7e-28 93.6 7.5 0.07 13.4 0.0 13.3 14 0 0 14 14 14 6 Ankyrin repeat PUB PF09409.5 KOO25462.1 - 3.3e-17 62.0 0.1 7.6e-17 60.8 0.0 1.5 1 0 0 1 1 1 1 PUB domain Pkinase_Tyr PF07714.12 KOO25462.1 - 6.5e-07 28.6 0.0 1.2e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 KOO25462.1 - 7.4e-07 28.5 0.0 1.3e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SAM_1 PF00536.25 KOO25462.1 - 5e-05 23.3 0.0 0.00012 22.1 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 KOO25462.1 - 8.5e-05 22.3 0.0 0.00022 21.0 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3BP5 PF05276.9 KOO25463.1 - 7.3e-07 28.7 10.3 1e-06 28.2 7.1 1.1 1 0 0 1 1 1 1 SH3 domain-binding protein 5 (SH3BP5) TMF_DNA_bd PF12329.3 KOO25463.1 - 0.91 9.3 14.6 0.11 12.3 4.1 3.0 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding LEA_1 PF03760.10 KOO25463.1 - 1.5 9.0 14.5 1.3 9.1 3.6 3.0 2 1 0 2 2 2 0 Late embryogenesis abundant (LEA) group 1 Retrotrans_gag PF03732.12 KOO25463.1 - 2.2 8.3 5.5 1.4 9.0 1.1 2.4 2 1 1 3 3 3 0 Retrotransposon gag protein YL1_C PF08265.6 KOO25464.1 - 1.1e-05 24.8 0.1 1.6e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Myc_N PF01056.13 KOO25464.1 - 0.044 12.9 3.5 0.051 12.7 2.4 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Voldacs PF03517.8 KOO25464.1 - 0.051 13.4 0.2 0.064 13.0 0.1 1.1 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling zf-HIT PF04438.11 KOO25464.1 - 0.073 12.7 0.1 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 HIT zinc finger Neur_chan_memb PF02932.11 KOO25464.1 - 0.19 11.5 2.3 0.23 11.2 1.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CENP-B_dimeris PF09026.5 KOO25464.1 - 0.24 11.6 6.2 0.35 11.1 4.3 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain HGTP_anticodon2 PF12745.2 KOO25464.1 - 0.82 8.7 6.9 1 8.4 4.8 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs CDC45 PF02724.9 KOO25464.1 - 0.9 7.4 5.4 0.91 7.4 3.8 1.0 1 0 0 1 1 1 0 CDC45-like protein LRR_6 PF13516.1 KOO25465.1 - 6.1e-26 87.5 1.6 4.8e-05 23.0 0.0 6.2 6 0 0 6 6 6 6 Leucine Rich repeat LRR_4 PF12799.2 KOO25465.1 - 6.1e-11 41.6 1.7 0.014 14.9 0.0 4.7 2 1 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO25465.1 - 1.6e-08 33.3 0.0 0.72 10.1 0.0 5.8 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_8 PF13855.1 KOO25465.1 - 2.9e-07 30.1 2.7 0.2 11.4 0.0 4.5 3 2 1 4 4 4 3 Leucine rich repeat LRR_7 PF13504.1 KOO25465.1 - 4e-06 26.1 2.5 11 6.7 0.0 5.8 6 0 0 6 6 6 1 Leucine rich repeat SIMPL PF04402.9 KOO25467.1 - 1.5 8.6 8.0 0.8 9.5 4.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF541) Pkinase PF00069.20 KOO25469.1 - 3.5e-52 177.1 0.0 5.5e-52 176.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25469.1 - 8.6e-24 84.0 0.0 1.6e-22 79.8 0.0 2.4 2 1 0 2 2 2 1 Protein tyrosine kinase RGS PF00615.14 KOO25469.1 - 2.6e-23 82.3 0.0 4.2e-23 81.6 0.0 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.6 KOO25469.1 - 0.027 13.9 0.1 0.045 13.2 0.1 1.5 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain XG_FTase PF03254.8 KOO25470.1 - 0.00023 19.8 0.2 0.00053 18.6 0.0 1.6 2 0 0 2 2 2 1 Xyloglucan fucosyltransferase Rotamase PF00639.16 KOO25471.1 - 2.3e-14 53.9 0.2 4.2e-14 53.0 0.0 1.5 2 0 0 2 2 2 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 KOO25471.1 - 3.4e-09 36.9 0.0 4.2e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 KOO25471.1 - 3.8e-05 24.3 0.0 9.6e-05 23.0 0.0 1.7 1 1 0 1 1 1 1 PPIC-type PPIASE domain Ion_trans PF00520.26 KOO25472.1 - 2.9e-167 552.2 40.7 3.9e-47 160.1 1.2 4.2 4 0 0 4 4 4 4 Ion transport protein Pentapeptide_4 PF13599.1 KOO25472.1 - 1.4e-11 44.0 0.0 0.00018 21.2 0.0 3.5 2 1 1 3 3 3 3 Pentapeptide repeats (9 copies) PKD_channel PF08016.7 KOO25472.1 - 4e-11 42.0 60.9 8.5e-08 31.0 4.0 9.0 8 2 0 9 9 9 6 Polycystin cation channel 5-FTHF_cyc-lig PF01812.15 KOO25474.1 - 1.3e-29 103.3 0.0 1.6e-29 102.9 0.0 1.1 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family zf-AN1 PF01428.11 KOO25475.1 - 0.29 11.0 5.6 2.6 7.9 0.1 3.1 2 1 1 3 3 3 0 AN1-like Zinc finger OrfB_Zn_ribbon PF07282.6 KOO25475.1 - 0.45 10.1 2.7 14 5.4 1.1 2.4 2 0 0 2 2 2 0 Putative transposase DNA-binding domain DNA_RNApol_7kD PF03604.8 KOO25475.1 - 9.5 5.7 13.1 1.3 8.5 0.1 3.2 2 1 1 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit Pkinase PF00069.20 KOO25476.1 - 3.6e-64 216.4 0.0 5.4e-64 215.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25476.1 - 8.5e-45 152.8 0.0 1.2e-44 152.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase IFT57 PF10498.4 KOO25476.1 - 2.3e-08 33.1 0.0 9.6e-06 24.5 0.2 2.1 1 1 1 2 2 2 2 Intra-flagellar transport protein 57 Kinase-like PF14531.1 KOO25476.1 - 2.4e-08 33.2 0.0 3.9e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOO25476.1 - 0.0032 16.5 0.2 0.01 14.9 0.2 1.8 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RTX PF02382.10 KOO25476.1 - 2.7 6.1 4.7 1.5 7.0 1.4 1.7 2 0 0 2 2 2 0 RTX N-terminal domain Asp_Arg_Hydrox PF05118.10 KOO25477.1 - 4.8e-30 104.5 0.0 6.2e-30 104.1 0.0 1.1 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase Cupin_2 PF07883.6 KOO25477.1 - 0.092 12.2 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Cupin domain Sdh5 PF03937.11 KOO25478.1 - 5.2e-22 77.3 0.6 8.5e-22 76.6 0.4 1.4 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase SAM_1 PF00536.25 KOO25480.1 - 5.9e-08 32.7 0.1 1.3e-07 31.6 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 KOO25480.1 - 1e-07 31.6 0.4 2.5e-07 30.4 0.1 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) TPR_16 PF13432.1 KOO25480.1 - 0.0022 18.6 22.2 0.0033 18.0 1.0 4.3 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO25480.1 - 0.0024 17.4 0.6 1.2 8.8 0.0 2.8 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 KOO25480.1 - 0.013 15.1 1.0 0.73 9.5 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO25480.1 - 0.11 12.4 7.7 0.31 11.0 0.1 3.2 3 0 0 3 3 2 0 Tetratricopeptide repeat DUF1192 PF06698.6 KOO25480.1 - 0.2 11.4 14.2 0.096 12.5 0.7 3.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1192) CENP-F_leu_zip PF10473.4 KOO25480.1 - 0.34 10.7 9.6 0.67 9.8 6.6 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6 PF04111.7 KOO25480.1 - 0.38 9.7 6.3 1.2 8.0 4.3 1.8 2 0 0 2 2 2 0 Autophagy protein Apg6 TPR_12 PF13424.1 KOO25480.1 - 0.44 10.5 9.4 3.6 7.5 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3886 PF13025.1 KOO25480.1 - 3.6 7.6 10.8 1.3 9.0 2.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3886) UAA PF08449.6 KOO25481.1 - 8.4e-43 146.4 6.3 1.1e-42 146.0 4.4 1.0 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 KOO25481.1 - 2.7e-08 33.6 11.0 1.1e-05 25.1 4.6 2.2 2 0 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.15 KOO25481.1 - 1.6e-05 24.9 13.3 0.0012 18.8 3.8 2.4 2 1 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.10 KOO25481.1 - 0.00032 19.9 2.7 0.00041 19.5 0.1 2.0 2 0 0 2 2 2 1 Nucleotide-sugar transporter EmrE PF13536.1 KOO25481.1 - 0.018 15.2 0.5 0.018 15.2 0.3 2.8 3 1 0 3 3 3 0 Multidrug resistance efflux transporter Pox_I5 PF04713.7 KOO25481.1 - 0.52 10.0 5.7 0.24 11.1 0.5 2.7 2 1 1 3 3 3 0 Poxvirus protein I5 PIH1 PF08190.7 KOO25482.1 - 2e-11 43.9 0.0 2.3e-11 43.7 0.0 1.1 1 0 0 1 1 1 1 pre-RNA processing PIH1/Nop17 EF-hand_1 PF00036.27 KOO25483.1 - 1.8e-11 42.4 0.8 4.4e-05 22.4 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO25483.1 - 4.6e-10 38.5 0.2 0.00029 20.4 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO25483.1 - 4.6e-09 36.2 0.2 7.9e-09 35.5 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO25483.1 - 5.6e-08 32.2 0.4 0.0002 20.9 0.1 3.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO25483.1 - 4.6e-07 28.8 0.5 0.0002 20.5 0.0 2.4 2 0 0 2 2 2 2 EF hand Glyco_hydro_1 PF00232.13 KOO25484.1 - 4.4e-160 532.7 0.0 5.4e-160 532.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 RtcB PF01139.12 KOO25485.1 - 7.3e-108 361.2 0.2 4.7e-104 348.7 0.1 2.8 1 1 0 1 1 1 1 tRNA-splicing ligase RtcB Acetyltransf_CG PF14542.1 KOO25485.1 - 0.092 12.6 0.0 0.3 11.0 0.0 1.8 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Dev_Cell_Death PF10539.4 KOO25486.1 - 2.2e-22 79.0 0.0 3.8e-22 78.2 0.0 1.3 1 1 0 1 1 1 1 Development and cell death domain LRR_6 PF13516.1 KOO25487.1 - 0.00022 20.9 16.9 0.072 13.1 0.0 7.3 8 0 0 8 8 8 1 Leucine Rich repeat DUF904 PF06005.7 KOO25487.1 - 0.0063 16.7 0.7 0.0063 16.7 0.5 2.4 1 1 1 2 2 2 1 Protein of unknown function (DUF904) PBP_sp32 PF07222.7 KOO25487.1 - 0.081 12.0 0.0 0.081 12.0 0.0 2.0 2 0 0 2 2 2 0 Proacrosin binding protein sp32 DUF2953 PF11167.3 KOO25487.1 - 0.13 12.1 0.0 0.35 10.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2953) IncA PF04156.9 KOO25488.1 - 0.00085 18.9 14.7 0.015 14.8 4.8 2.5 1 1 1 2 2 2 2 IncA protein Mnd1 PF03962.10 KOO25488.1 - 0.051 13.2 17.9 0.039 13.6 0.6 3.4 1 1 1 3 3 3 0 Mnd1 family XLF PF09302.6 KOO25488.1 - 0.058 13.1 1.7 0.1 12.3 0.8 1.7 1 1 0 1 1 1 0 XLF (XRCC4-like factor) ATG16 PF08614.6 KOO25488.1 - 0.94 9.2 24.1 0.024 14.4 1.0 4.2 2 1 2 4 4 4 0 Autophagy protein 16 (ATG16) IFT57 PF10498.4 KOO25488.1 - 1.2 7.7 9.8 0.3 9.7 0.4 2.3 1 1 0 2 2 2 0 Intra-flagellar transport protein 57 APG6 PF04111.7 KOO25488.1 - 1.4 7.8 20.8 0.049 12.6 0.8 3.0 2 1 1 3 3 3 0 Autophagy protein Apg6 RIB43A PF05914.7 KOO25489.1 - 0.065 11.8 3.2 0.087 11.4 2.2 1.2 1 0 0 1 1 1 0 RIB43A PerC PF06069.6 KOO25489.1 - 0.11 12.5 0.8 0.37 10.8 0.0 2.0 1 1 1 2 2 2 0 PerC transcriptional activator TPR_11 PF13414.1 KOO25490.1 - 1.4e-35 120.7 20.8 1.1e-09 37.8 1.2 7.0 3 2 5 8 8 8 6 TPR repeat TPR_17 PF13431.1 KOO25490.1 - 1.5e-20 71.6 7.0 0.012 15.7 0.0 8.9 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_2 PF07719.12 KOO25490.1 - 1.6e-20 71.3 22.0 0.00016 21.3 0.2 9.8 9 2 0 9 9 9 6 Tetratricopeptide repeat TPR_16 PF13432.1 KOO25490.1 - 1.4e-19 70.2 47.3 1.5e-09 38.3 0.2 8.1 6 1 3 9 9 9 6 Tetratricopeptide repeat TPR_1 PF00515.23 KOO25490.1 - 2.5e-16 58.4 15.5 0.00012 21.4 0.0 10.2 10 1 0 10 10 10 5 Tetratricopeptide repeat PhyH PF05721.8 KOO25490.1 - 2.2e-14 53.9 0.1 3.9e-14 53.2 0.1 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) TPR_8 PF13181.1 KOO25490.1 - 8.9e-13 47.0 0.0 0.01 15.5 0.0 6.6 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOO25490.1 - 3.4e-12 45.8 42.5 0.0012 19.2 0.0 9.4 4 1 6 10 10 8 6 Tetratricopeptide repeat TPR_12 PF13424.1 KOO25490.1 - 3.4e-12 46.1 18.8 0.00013 21.8 0.3 5.4 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_19 PF14559.1 KOO25490.1 - 2.5e-09 37.3 17.1 0.012 15.9 0.0 6.9 5 1 2 7 7 7 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOO25490.1 - 6.6e-07 29.3 10.0 0.94 10.0 0.0 7.2 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO25490.1 - 0.0018 17.9 14.5 0.51 10.2 0.1 7.6 7 2 1 8 8 8 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOO25490.1 - 0.0031 17.3 24.1 0.12 12.1 1.6 5.8 2 2 4 6 6 6 3 Tetratricopeptide repeat Ferritin_2 PF13668.1 KOO25490.1 - 0.015 15.2 0.0 0.042 13.7 0.0 1.9 1 1 0 1 1 1 0 Ferritin-like domain TPR_20 PF14561.1 KOO25490.1 - 0.089 12.9 4.3 6.9 6.8 0.0 4.4 2 1 2 4 4 4 0 Tetratricopeptide repeat Glyoxalase_2 PF12681.2 KOO25491.1 - 1.6e-05 25.4 0.0 5.3e-05 23.7 0.0 1.8 2 0 0 2 2 2 1 Glyoxalase-like domain IU_nuc_hydro PF01156.14 KOO25492.1 - 0.011 14.9 0.1 0.02 14.0 0.1 1.4 1 0 0 1 1 1 0 Inosine-uridine preferring nucleoside hydrolase Glyco_transf_34 PF05637.7 KOO25493.1 - 3.5e-28 98.7 1.1 2e-27 96.2 0.8 2.0 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Sulfotransfer_1 PF00685.22 KOO25493.1 - 1e-05 24.9 0.0 5.6e-05 22.5 0.0 2.1 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.1 KOO25493.1 - 0.001 20.0 0.1 0.0091 16.9 0.0 2.5 2 1 0 2 2 2 1 Sulfotransferase family Sulfotransfer_2 PF03567.9 KOO25493.1 - 0.02 14.5 0.0 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 Sulfotransferase family PAN_4 PF14295.1 KOO25494.1 - 0.021 14.5 1.7 0.058 13.1 1.2 1.8 1 0 0 1 1 1 0 PAN domain PAN_1 PF00024.21 KOO25494.1 - 0.1 12.3 1.6 0.11 12.2 0.0 1.9 2 1 0 2 2 2 0 PAN domain Fanconi_A PF03511.9 KOO25495.1 - 0.038 13.7 0.0 0.071 12.9 0.0 1.4 1 0 0 1 1 1 0 Fanconi anaemia group A protein Mrr_cat PF04471.7 KOO25496.1 - 0.039 13.7 0.1 0.12 12.1 0.0 1.8 2 1 0 2 2 2 0 Restriction endonuclease FrhB_FdhB_N PF04422.8 KOO25496.1 - 0.08 12.8 0.1 0.21 11.4 0.0 1.7 1 1 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term Helicase_C PF00271.26 KOO25497.1 - 1e-11 44.4 0.0 2.2e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOO25497.1 - 4.4e-07 29.5 0.0 8e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SE PF00437.15 KOO25497.1 - 0.00051 19.0 0.1 0.00092 18.1 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.1 KOO25497.1 - 0.0013 18.8 0.2 0.0054 16.8 0.1 2.0 1 1 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.13 KOO25497.1 - 0.009 15.4 0.0 0.02 14.4 0.0 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_25 PF13481.1 KOO25497.1 - 0.0098 15.3 0.0 0.024 14.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain ResIII PF04851.10 KOO25497.1 - 0.033 14.0 0.0 3.9 7.2 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit ABC_tran PF00005.22 KOO25497.1 - 0.049 13.9 0.2 0.19 12.0 0.0 2.0 2 0 0 2 2 2 0 ABC transporter AAA_19 PF13245.1 KOO25497.1 - 0.079 12.7 3.3 0.19 11.4 1.1 2.7 2 0 0 2 2 2 0 Part of AAA domain PhoH PF02562.11 KOO25497.1 - 0.093 11.9 0.1 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_29 PF13555.1 KOO25497.1 - 0.13 11.7 0.1 0.35 10.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.7 KOO25497.1 - 0.16 11.5 0.6 0.41 10.2 0.1 1.9 2 0 0 2 2 2 0 NACHT domain DAP3 PF10236.4 KOO25497.1 - 0.17 10.7 0.0 0.27 10.1 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_23 PF13476.1 KOO25497.1 - 0.34 11.2 0.1 0.54 10.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Arm PF00514.18 KOO25498.1 - 2.7e-13 49.1 13.1 0.00056 19.6 0.1 5.9 5 1 0 5 5 5 5 Armadillo/beta-catenin-like repeat RICTOR_N PF14664.1 KOO25498.1 - 0.015 13.8 0.3 0.025 13.1 0.2 1.3 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term KAP PF05804.7 KOO25498.1 - 0.023 12.6 1.2 3.7 5.3 0.0 2.1 1 1 0 2 2 2 0 Kinesin-associated protein (KAP) HEAT_EZ PF13513.1 KOO25498.1 - 0.12 12.8 6.9 0.94 10.0 0.0 4.2 2 1 1 3 3 3 0 HEAT-like repeat HEAT_2 PF13646.1 KOO25498.1 - 0.18 12.1 10.2 2.1 8.6 0.1 3.6 1 1 2 3 3 3 0 HEAT repeats F-box PF00646.28 KOO25499.1 - 0.0018 17.8 0.4 0.0038 16.8 0.3 1.6 1 0 0 1 1 1 1 F-box domain FHA PF00498.21 KOO25499.1 - 0.012 15.7 0.3 0.068 13.3 0.2 2.1 1 1 0 1 1 1 0 FHA domain F-box-like PF12937.2 KOO25499.1 - 0.015 15.0 0.9 0.026 14.2 0.2 1.7 2 0 0 2 2 2 0 F-box-like DUF3152 PF11350.3 KOO25499.1 - 0.11 12.0 0.2 0.18 11.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3152) HSBP1 PF06825.7 KOO25500.1 - 6e-27 92.9 1.0 7.2e-27 92.7 0.7 1.1 1 0 0 1 1 1 1 Heat shock factor binding protein 1 Ank_2 PF12796.2 KOO25501.1 - 1.1e-20 73.7 3.3 6.6e-16 58.4 1.4 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO25501.1 - 1.1e-18 66.0 0.5 3.5e-08 32.8 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 KOO25501.1 - 7.8e-14 50.4 0.4 6.4e-06 25.9 0.0 3.1 3 0 0 3 3 2 2 Ankyrin repeat Ank_5 PF13857.1 KOO25501.1 - 5.2e-13 48.7 1.4 1.3e-08 34.7 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO25501.1 - 1.2e-12 47.9 0.5 4.5e-09 36.5 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) EF-hand_6 PF13405.1 KOO25501.1 - 1.3e-10 40.1 0.5 0.00012 21.6 0.2 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO25501.1 - 3.5e-10 39.8 0.2 1e-09 38.3 0.1 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO25501.1 - 2.5e-09 35.7 0.1 0.00074 18.6 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO25501.1 - 1.1e-07 31.3 0.0 3e-07 29.9 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair ART PF01129.13 KOO25501.1 - 1.3e-06 27.6 0.0 3e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase EF-hand_5 PF13202.1 KOO25501.1 - 4.5e-05 22.5 0.7 0.032 13.5 0.5 2.6 2 0 0 2 2 2 2 EF hand ADPrib_exo_Tox PF03496.9 KOO25501.1 - 0.00022 20.5 0.0 0.00048 19.3 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme LRR_6 PF13516.1 KOO25501.1 - 0.0011 18.7 0.3 0.0052 16.7 0.0 2.3 2 0 0 2 2 1 1 Leucine Rich repeat LRR_4 PF12799.2 KOO25501.1 - 0.087 12.4 0.0 0.47 10.1 0.0 2.3 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) YopD PF05844.7 KOO25501.1 - 0.21 10.5 5.0 0.36 9.8 3.5 1.2 1 0 0 1 1 1 0 YopD protein ABC1 PF03109.11 KOO25502.1 - 2.6e-16 59.6 0.0 1.1e-15 57.6 0.0 2.0 2 0 0 2 2 2 1 ABC1 family Glyco_hydro_3_C PF01915.17 KOO25503.1 - 0.029 13.8 0.1 0.058 12.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain EF-hand_1 PF00036.27 KOO25504.1 - 5.8e-25 84.6 19.2 4.6e-06 25.5 0.1 8.2 7 0 0 7 7 7 4 EF hand EF-hand_7 PF13499.1 KOO25504.1 - 3.9e-21 74.9 17.5 2e-09 37.4 1.5 6.7 3 3 2 5 5 5 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO25504.1 - 4.8e-19 66.4 24.6 0.00039 20.0 0.2 8.5 9 0 0 9 9 9 6 EF-hand domain EF-hand_8 PF13833.1 KOO25504.1 - 1.1e-16 60.1 17.1 0.00039 19.9 0.1 6.7 6 0 0 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.1 KOO25504.1 - 2.7e-15 54.9 22.3 7.4e-06 25.0 0.2 6.9 6 0 0 6 6 6 3 EF hand SPARC_Ca_bdg PF10591.4 KOO25504.1 - 0.0017 18.3 0.2 0.027 14.5 0.0 2.8 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOO25504.1 - 0.11 12.3 1.4 4.7 7.1 0.0 3.5 5 0 0 5 5 5 0 EF-hand domain Mito_carr PF00153.22 KOO25505.1 - 3.3e-47 158.1 2.0 7.8e-19 67.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein TTL PF03133.10 KOO25506.1 - 4e-49 167.1 0.0 7.1e-49 166.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 KOO25506.1 - 3.9e-06 25.8 0.0 0.061 12.1 0.0 2.3 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATP-grasp_4 PF13535.1 KOO25506.1 - 0.0019 17.9 0.0 0.07 12.8 0.0 2.4 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_3 PF02655.9 KOO25506.1 - 0.2 11.5 0.0 0.75 9.6 0.0 1.9 2 0 0 2 2 2 0 ATP-grasp domain Ank PF00023.25 KOO25507.1 - 1.8e-20 71.6 0.1 7.7e-08 31.7 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.2 KOO25507.1 - 2.6e-20 72.5 0.0 5.9e-12 45.7 0.0 3.0 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO25507.1 - 2.8e-19 69.1 1.5 6.4e-11 42.4 0.2 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO25507.1 - 7e-16 57.8 2.1 1.3e-11 44.3 0.4 3.5 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO25507.1 - 9.2e-15 53.2 0.1 1.6e-05 24.7 0.0 4.3 4 0 0 4 4 4 4 Ankyrin repeat DUF4350 PF14258.1 KOO25508.1 - 0.12 12.6 0.0 0.29 11.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4350) GYF PF02213.11 KOO25510.1 - 1.2e-48 162.5 0.0 2.6e-12 46.1 0.0 5.2 5 0 0 5 5 5 5 GYF domain DUF4339 PF14237.1 KOO25510.1 - 2.8e-17 62.0 0.0 0.0056 16.2 0.0 5.6 5 0 0 5 5 5 5 Domain of unknown function (DUF4339) Alveol-reg_P311 PF11092.3 KOO25510.1 - 0.017 15.0 0.0 0.78 9.7 0.0 3.3 4 0 0 4 4 4 0 Neuronal protein 3.1 (p311) EF-hand_1 PF00036.27 KOO25511.1 - 3.1e-28 94.9 7.2 7e-07 28.1 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO25511.1 - 3.6e-26 91.0 5.2 5e-14 52.1 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO25511.1 - 3.2e-23 79.4 8.0 1.7e-06 27.4 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO25511.1 - 1.3e-22 77.9 13.2 4e-06 25.9 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO25511.1 - 1.1e-19 69.8 12.4 6.3e-08 32.1 0.1 4.2 2 2 2 4 4 4 4 EF-hand domain pair Pkinase PF00069.20 KOO25511.1 - 2e-12 46.8 0.0 2.7e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SPARC_Ca_bdg PF10591.4 KOO25511.1 - 8.1e-07 29.0 0.0 0.0057 16.6 0.0 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO25511.1 - 1e-05 25.1 1.8 0.0034 17.0 0.0 3.4 1 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand TerB PF05099.8 KOO25511.1 - 0.0059 16.3 1.6 0.074 12.7 0.2 2.6 1 1 1 2 2 2 1 Tellurite resistance protein TerB EF-hand_9 PF14658.1 KOO25511.1 - 0.025 14.4 0.2 4.1 7.4 0.0 2.8 2 1 1 3 3 3 0 EF-hand domain Pkinase_Tyr PF07714.12 KOO25511.1 - 0.045 12.8 0.0 0.06 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Caleosin PF05042.8 KOO25511.1 - 0.083 12.4 0.0 15 5.1 0.0 2.7 2 1 1 3 3 3 0 Caleosin related protein DUF4588 PF15251.1 KOO25511.1 - 0.087 12.7 0.8 0.37 10.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4588) OB_NTP_bind PF07717.11 KOO25512.1 - 7.9e-32 109.4 0.1 2.2e-31 108.0 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 KOO25512.1 - 1e-24 86.4 1.1 3.7e-24 84.6 0.0 2.5 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.26 KOO25512.1 - 4e-12 45.8 0.0 1.1e-11 44.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 KOO25512.1 - 7.5e-05 22.8 0.3 0.001 19.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 KOO25512.1 - 0.00028 19.8 0.0 0.00062 18.7 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein DEAD PF00270.24 KOO25512.1 - 0.0014 18.1 0.0 0.0048 16.4 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase PWI PF01480.12 KOO25512.1 - 0.018 15.1 0.0 0.06 13.4 0.0 2.0 1 0 0 1 1 1 0 PWI domain AAA_19 PF13245.1 KOO25512.1 - 0.019 14.7 0.1 0.019 14.7 0.0 2.8 3 0 0 3 3 3 0 Part of AAA domain ABC_tran PF00005.22 KOO25512.1 - 0.048 13.9 0.2 0.41 10.9 0.0 2.5 2 0 0 2 2 2 0 ABC transporter AAA_23 PF13476.1 KOO25512.1 - 0.63 10.3 0.0 0.63 10.3 0.0 3.4 2 1 0 2 2 1 0 AAA domain PRP1_N PF06424.7 KOO25512.1 - 9.6 6.5 20.1 1.1 9.5 6.8 2.5 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal Lipase_GDSL_2 PF13472.1 KOO25513.1 - 7.8e-05 22.8 0.0 0.0002 21.5 0.0 1.7 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family DUF3506 PF12014.3 KOO25514.1 - 5.4 6.8 15.3 82 3.0 0.0 7.2 2 2 3 7 7 7 0 Domain of unknown function (DUF3506) RRM_1 PF00076.17 KOO25515.1 - 6.9e-22 76.8 0.0 1.1e-11 44.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO25515.1 - 1.5e-18 66.5 0.0 5.5e-10 39.0 0.0 2.7 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO25515.1 - 1.5e-13 50.3 0.0 1e-05 25.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOPS PF08075.6 KOO25515.1 - 0.0006 20.1 0.3 0.0017 18.6 0.0 1.9 2 0 0 2 2 2 1 NOPS (NUC059) domain DUF896 PF05979.7 KOO25515.1 - 1 9.0 7.8 0.24 11.0 2.9 1.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) CRAL_TRIO PF00650.15 KOO25516.1 - 7e-10 38.6 0.0 1.2e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain DUF1279 PF06916.8 KOO25517.1 - 3.3e-18 65.7 0.1 8.7e-18 64.4 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) MR_MLE_C PF13378.1 KOO25517.1 - 0.039 13.9 0.0 0.074 13.0 0.0 1.5 2 0 0 2 2 2 0 Enolase C-terminal domain-like PAP_fibrillin PF04755.7 KOO25518.1 - 7.3e-11 42.1 0.0 4.3e-09 36.3 0.0 2.3 1 1 0 1 1 1 1 PAP_fibrillin Thioredoxin PF00085.15 KOO25520.1 - 4.1e-19 68.1 0.0 7.5e-19 67.3 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.16 KOO25520.1 - 6.9e-07 28.9 0.0 1.3e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.1 KOO25520.1 - 6.1e-05 22.9 0.0 0.00031 20.6 0.0 2.2 2 1 0 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.1 KOO25520.1 - 6.6e-05 23.0 0.0 0.0011 19.0 0.0 2.6 2 1 0 2 2 2 1 Thioredoxin-like domain ClpS PF02617.12 KOO25520.1 - 0.00011 21.8 0.0 0.00018 21.1 0.0 1.4 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS Thioredoxin_8 PF13905.1 KOO25520.1 - 0.00011 22.2 0.0 0.00024 21.1 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.5 KOO25520.1 - 0.0011 18.5 0.0 0.0019 17.7 0.0 1.4 1 0 0 1 1 1 1 Redoxin Thioredoxin_9 PF14595.1 KOO25520.1 - 0.006 16.1 0.0 0.012 15.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Glutaredoxin PF00462.19 KOO25520.1 - 0.088 12.8 0.0 0.66 10.0 0.0 2.4 2 1 0 2 2 2 0 Glutaredoxin Foie-gras_1 PF11817.3 KOO25522.1 - 1.8e-35 122.6 3.8 1.8e-35 122.6 2.6 1.5 2 0 0 2 2 2 1 Foie gras liver health family 1 Gryzun PF07919.7 KOO25522.1 - 1.4e-23 83.0 0.0 4e-14 51.8 0.0 2.3 2 0 0 2 2 2 2 Gryzun, putative trafficking through Golgi Gryzun-like PF12742.2 KOO25522.1 - 0.0076 16.0 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Gryzun, putative Golgi trafficking EF-hand_1 PF00036.27 KOO25523.1 - 7.8e-09 34.2 0.3 2.7e-05 23.1 0.0 3.0 2 1 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO25523.1 - 1.6e-08 34.5 0.5 3.3e-08 33.5 0.4 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO25523.1 - 2e-08 33.4 0.4 0.00034 20.2 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain RHD3 PF05879.7 KOO25523.1 - 1.2e-06 26.8 0.6 1.6e-06 26.4 0.4 1.1 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) EF-hand_8 PF13833.1 KOO25523.1 - 5.1e-06 26.0 1.1 2.7e-05 23.6 0.2 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO25523.1 - 3.4e-05 22.9 3.9 0.06 12.7 0.3 3.1 3 0 0 3 3 3 2 EF hand EF-hand_10 PF14788.1 KOO25523.1 - 0.031 13.9 0.0 0.06 13.0 0.0 1.5 1 0 0 1 1 1 0 EF hand EF-hand_9 PF14658.1 KOO25523.1 - 0.033 14.0 0.0 0.086 12.7 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain VWA_2 PF13519.1 KOO25524.1 - 1.4e-12 48.0 0.2 1.8e-12 47.6 0.1 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.9 KOO25524.1 - 4.2e-07 29.7 0.0 5.8e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like VWA PF00092.23 KOO25524.1 - 0.013 15.1 0.2 0.019 14.6 0.1 1.2 1 0 0 1 1 1 0 von Willebrand factor type A domain Glyco_transf_90 PF05686.7 KOO25525.1 - 5.2e-34 117.6 0.0 6.9e-34 117.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.1 KOO25525.1 - 4e-05 23.7 0.0 7.5e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Aa_trans PF01490.13 KOO25526.1 - 9.5e-48 162.6 20.0 1.2e-47 162.3 13.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 KOO25526.1 - 1.9e-07 30.2 5.3 1.9e-07 30.2 3.6 2.6 3 0 0 3 3 3 2 Tryptophan/tyrosine permease family CbtB PF09489.5 KOO25527.1 - 0.28 11.1 0.1 0.28 11.1 0.1 2.6 3 0 0 3 3 3 0 Probable cobalt transporter subunit (CbtB) CBF PF03914.12 KOO25528.1 - 0.16 11.4 0.1 0.3 10.5 0.1 1.5 1 1 0 1 1 1 0 CBF/Mak21 family DUF4094 PF13334.1 KOO25529.1 - 0.012 16.0 0.5 0.03 14.6 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) DUF2244 PF10003.4 KOO25529.1 - 0.055 12.8 0.1 0.088 12.1 0.0 1.4 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) PSK_trans_fac PF07704.6 KOO25530.1 - 0.12 13.1 5.5 0.11 13.1 2.6 1.9 2 0 0 2 2 2 0 Rv0623-like transcription factor DUF1498 PF07385.7 KOO25530.1 - 0.13 11.4 0.0 0.16 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1498) Bgal_small_N PF02929.12 KOO25531.1 - 8.4e-19 67.6 0.0 1.1e-18 67.3 0.0 1.1 1 0 0 1 1 1 1 Beta galactosidase small chain EF-hand_7 PF13499.1 KOO25532.1 - 3e-34 116.9 0.1 1.2e-08 34.8 0.0 5.3 5 0 0 5 5 5 5 EF-hand domain pair EF-hand_6 PF13405.1 KOO25532.1 - 6.4e-33 109.6 3.2 0.0001 21.8 0.0 8.4 8 0 0 8 8 8 7 EF-hand domain EF-hand_1 PF00036.27 KOO25532.1 - 2.2e-31 104.7 1.1 0.00034 19.6 0.1 8.3 8 0 0 8 8 8 7 EF hand EF-hand_8 PF13833.1 KOO25532.1 - 3.4e-25 87.4 1.8 3.8e-05 23.1 0.0 5.9 4 2 2 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.1 KOO25532.1 - 4.2e-15 54.3 10.5 0.0037 16.5 0.5 7.6 7 0 0 7 7 7 4 EF hand SPARC_Ca_bdg PF10591.4 KOO25532.1 - 6.2e-05 22.9 0.0 1.1 9.3 0.0 4.3 4 0 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.8 KOO25532.1 - 0.0042 16.6 0.0 0.12 11.9 0.0 3.1 2 1 1 3 3 3 1 Caleosin related protein EF-hand_9 PF14658.1 KOO25532.1 - 0.019 14.8 0.0 4.9 7.1 0.0 4.0 4 0 0 4 4 4 0 EF-hand domain RGS PF00615.14 KOO25533.1 - 5.3e-18 65.2 0.0 4e-14 52.7 0.0 4.0 3 1 0 3 3 3 2 Regulator of G protein signaling domain PH PF00169.24 KOO25533.1 - 2.5e-05 24.4 0.0 0.0022 18.1 0.0 2.8 3 0 0 3 3 3 1 PH domain Toxin_40 PF15520.1 KOO25534.1 - 0.039 13.4 0.3 0.079 12.4 0.2 1.4 1 0 0 1 1 1 0 Putative toxin 40 FecR PF04773.8 KOO25534.1 - 0.059 13.6 1.3 0.19 11.9 0.0 2.5 3 1 1 4 4 4 0 FecR protein PT-VENN PF04829.8 KOO25534.1 - 8.4 6.0 9.1 34 4.0 0.1 2.6 2 0 0 2 2 2 0 Pre-toxin domain with VENN motif DUF4267 PF14087.1 KOO25535.1 - 5.5e-12 45.2 1.8 5.5e-12 45.2 1.2 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4267) RRM_1 PF00076.17 KOO25537.1 - 9.4e-28 95.6 0.5 4.2e-13 48.7 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO25537.1 - 1.5e-17 63.1 0.0 2.2e-12 46.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO25537.1 - 3.8e-13 49.1 0.1 1.4e-05 24.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) SIMPL PF04402.9 KOO25537.1 - 3.5e-05 23.7 1.1 5.2e-05 23.2 0.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF541) DUF4523 PF15023.1 KOO25537.1 - 5.7e-05 22.6 0.0 0.00011 21.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4523) SAP30_Sin3_bdg PF13867.1 KOO25538.1 - 3.1e-19 68.5 0.4 4.7e-19 68.0 0.3 1.3 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 Acyl_transf_3 PF01757.17 KOO25539.1 - 0.0061 15.4 14.1 0.014 14.2 9.8 1.6 1 1 0 1 1 1 1 Acyltransferase family YbjM PF11045.3 KOO25539.1 - 0.16 11.7 6.6 0.054 13.2 2.4 1.9 2 0 0 2 2 2 0 Putative inner membrane protein of Enterobacteriaceae PX PF00787.19 KOO25541.1 - 3.1e-17 62.3 0.1 5.1e-17 61.6 0.1 1.3 1 0 0 1 1 1 1 PX domain VWA_2 PF13519.1 KOO25543.1 - 0.015 15.4 0.0 0.02 14.9 0.0 1.2 1 0 0 1 1 1 0 von Willebrand factor type A domain VWA_CoxE PF05762.9 KOO25543.1 - 0.026 13.6 0.2 0.026 13.6 0.1 1.7 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein Nucleotid_trans PF03407.11 KOO25543.1 - 0.036 13.8 0.0 0.049 13.3 0.0 1.2 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Ank_2 PF12796.2 KOO25544.1 - 1.9e-27 95.3 0.4 1.9e-15 56.9 0.2 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO25544.1 - 3.3e-25 87.5 4.0 2.7e-08 33.8 0.0 3.9 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO25544.1 - 7.2e-23 80.5 0.1 7.5e-11 42.2 0.0 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO25544.1 - 1.5e-22 78.1 0.9 1.6e-07 30.8 0.0 4.8 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.1 KOO25544.1 - 5.3e-17 60.2 0.1 0.0016 18.4 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Reticulon PF02453.12 KOO25545.1 - 3e-07 30.2 0.1 3.8e-07 29.8 0.1 1.2 1 0 0 1 1 1 1 Reticulon PGG PF13962.1 KOO25545.1 - 0.026 14.1 0.1 0.044 13.4 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function Mt_ATP-synt_B PF05405.9 KOO25545.1 - 0.028 13.8 0.3 0.035 13.5 0.2 1.1 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Peptidase_M50B PF13398.1 KOO25545.1 - 0.04 13.3 0.2 0.045 13.1 0.1 1.1 1 0 0 1 1 1 0 Peptidase M50B-like ATP-synt_B PF00430.13 KOO25545.1 - 1.1 9.0 5.9 0.32 10.7 1.9 1.6 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) TPR_11 PF13414.1 KOO25546.1 - 7.8e-16 57.4 2.2 4.3e-12 45.5 0.7 2.3 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 KOO25546.1 - 1.5e-08 33.9 3.0 0.016 15.1 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO25546.1 - 2.6e-08 34.2 8.0 0.0014 19.2 0.8 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO25546.1 - 2e-06 27.5 1.2 0.0013 18.5 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO25546.1 - 3.8e-06 27.1 2.6 0.0022 18.3 0.1 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO25546.1 - 5.8e-06 26.4 7.5 0.00028 21.2 0.6 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO25546.1 - 4.4e-05 22.8 1.1 0.014 14.9 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_4 PF07721.9 KOO25546.1 - 0.00015 21.8 2.6 0.13 12.8 1.2 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOO25546.1 - 0.00027 20.8 1.8 0.0066 16.3 0.2 3.0 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO25546.1 - 0.0014 18.6 0.0 0.058 13.6 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.1 KOO25546.1 - 0.0082 16.0 3.1 1.4 8.9 0.1 3.0 3 0 0 3 3 2 2 Tetratricopeptide repeat Apc3 PF12895.2 KOO25546.1 - 0.013 15.5 0.8 0.036 14.1 0.1 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 KOO25546.1 - 0.015 15.0 1.7 0.72 9.8 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOO25546.1 - 0.021 14.6 0.4 9.1 6.3 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO25546.1 - 0.04 14.3 0.1 0.29 11.6 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat BTAD PF03704.12 KOO25546.1 - 0.071 13.4 2.2 2.5 8.4 1.5 2.4 1 1 0 1 1 1 0 Bacterial transcriptional activator domain Coatomer_E PF04733.9 KOO25546.1 - 0.14 11.3 0.2 6.5 5.8 0.1 2.2 1 1 1 2 2 2 0 Coatomer epsilon subunit YhjQ PF06564.7 KOO25548.1 - 0.081 12.2 0.1 0.098 11.9 0.0 1.1 1 0 0 1 1 1 0 YhjQ protein AAA PF00004.24 KOO25549.1 - 4.5e-10 39.8 0.0 8.8e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 KOO25549.1 - 0.00019 20.8 0.2 0.0026 17.1 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.1 KOO25549.1 - 0.0005 20.8 1.4 0.0011 19.7 0.2 2.2 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.7 KOO25549.1 - 0.0019 17.2 0.0 0.0035 16.4 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus RNA_helicase PF00910.17 KOO25549.1 - 0.0091 16.1 0.0 0.018 15.1 0.0 1.5 1 0 0 1 1 1 1 RNA helicase KaiC PF06745.8 KOO25549.1 - 0.018 14.2 0.0 0.032 13.3 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_18 PF13238.1 KOO25549.1 - 0.02 15.2 0.0 0.045 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 KOO25549.1 - 0.029 14.6 0.0 0.058 13.6 0.0 1.6 1 0 0 1 1 1 0 ABC transporter FtsK_SpoIIIE PF01580.13 KOO25549.1 - 0.035 13.5 0.0 0.061 12.7 0.0 1.5 1 1 0 1 1 1 0 FtsK/SpoIIIE family AAA_16 PF13191.1 KOO25549.1 - 0.058 13.3 0.5 0.21 11.5 0.3 2.3 1 1 1 2 2 2 0 AAA ATPase domain AAA_5 PF07728.9 KOO25549.1 - 0.062 13.0 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Bombinin PF05298.6 KOO25549.1 - 0.075 12.5 0.3 3.6 7.0 0.0 2.3 2 0 0 2 2 2 0 Bombinin AAA_33 PF13671.1 KOO25549.1 - 0.078 12.8 0.0 0.2 11.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 KOO25549.1 - 0.078 12.5 0.2 0.14 11.6 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 KOO25549.1 - 0.13 12.1 0.9 0.36 10.7 0.0 2.1 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.1 KOO25549.1 - 0.14 12.2 0.1 0.36 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF221 PF02714.10 KOO25550.1 - 4.9e-12 45.3 1.9 1.1e-11 44.1 1.3 1.6 1 1 0 1 1 1 1 Domain of unknown function DUF221 AmoC PF04896.7 KOO25550.1 - 0.0091 15.0 0.1 0.017 14.2 0.0 1.3 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C zf-trcl PF13451.1 KOO25551.1 - 7.2e-06 25.5 0.2 1.3e-05 24.7 0.2 1.4 1 0 0 1 1 1 1 Probable zinc-binding domain SR-25 PF10500.4 KOO25551.1 - 0.13 11.7 4.9 0.16 11.4 3.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein GKAP PF03359.8 KOO25551.1 - 6 6.3 10.3 7.1 6.1 7.1 1.1 1 0 0 1 1 1 0 Guanylate-kinase-associated protein (GKAP) protein Peptidase_S24 PF00717.18 KOO25552.1 - 0.028 14.0 0.0 0.044 13.4 0.0 1.3 1 0 0 1 1 1 0 Peptidase S24-like DUF498 PF04430.9 KOO25552.1 - 0.044 13.3 0.0 0.08 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF498/DUF598) DUF3628 PF12300.3 KOO25553.1 - 2.7 8.0 6.3 3.6 7.5 4.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3628) Ank_2 PF12796.2 KOO25554.1 - 1.9e-29 101.8 6.2 1.5e-09 38.0 0.1 3.3 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO25554.1 - 5.2e-25 85.9 14.3 9.3e-09 34.6 0.2 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.1 KOO25554.1 - 9.6e-24 83.3 4.5 1.1e-07 32.1 0.0 4.0 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO25554.1 - 1.3e-21 76.0 10.4 1.4e-07 31.5 0.3 4.2 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO25554.1 - 4.9e-19 66.5 4.5 5.7e-05 22.9 0.0 5.6 5 0 0 5 5 5 3 Ankyrin repeat NHL PF01436.16 KOO25555.1 - 3.8e-26 89.6 15.9 1.4e-06 27.9 0.8 6.3 6 0 0 6 6 6 5 NHL repeat SGL PF08450.7 KOO25555.1 - 0.0027 17.1 0.1 0.21 10.9 0.0 3.0 2 2 2 4 4 4 1 SMP-30/Gluconolaconase/LRE-like region NAD_binding_10 PF13460.1 KOO25556.1 - 1.9e-19 70.3 0.3 1.1e-09 38.6 0.1 2.7 2 1 0 2 2 2 2 NADH(P)-binding CIA30 PF08547.7 KOO25556.1 - 7.3e-14 51.9 0.0 1.2e-13 51.2 0.0 1.4 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) NmrA PF05368.8 KOO25556.1 - 1.2e-07 31.2 0.0 3.7e-06 26.3 0.0 2.4 2 0 0 2 2 2 1 NmrA-like family 3Beta_HSD PF01073.14 KOO25556.1 - 0.022 13.4 0.0 0.038 12.6 0.0 1.4 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family PDEase_I PF00233.14 KOO25557.1 - 5.3e-66 222.7 0.6 1.6e-65 221.2 0.1 1.8 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase Ion_trans PF00520.26 KOO25557.1 - 9.8e-10 38.0 10.2 9.8e-10 38.0 7.1 1.5 2 0 0 2 2 2 1 Ion transport protein Peptidase_C48 PF02902.14 KOO25560.1 - 9e-23 81.0 0.0 2.6e-21 76.2 0.0 2.7 2 1 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain ubiquitin PF00240.18 KOO25561.1 - 2.4e-13 49.2 0.1 4.1e-13 48.5 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 KOO25561.1 - 2.7e-05 23.7 0.0 4.9e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.3 KOO25562.1 - 7.1e-23 80.0 0.0 1.1e-22 79.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like PARP PF00644.15 KOO25562.1 - 4.8e-13 49.0 0.0 7.3e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain ubiquitin PF00240.18 KOO25562.1 - 2.7e-09 36.3 0.0 4.6e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family WWE PF02825.15 KOO25562.1 - 1.1e-08 34.4 0.0 3e-08 32.9 0.0 1.8 1 1 0 1 1 1 1 WWE domain Pentapeptide_4 PF13599.1 KOO25563.1 - 6.9e-17 61.0 0.0 5e-08 32.6 0.0 2.2 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Toxin_54 PF15533.1 KOO25563.1 - 0.02 15.1 0.1 4.1 7.7 0.1 3.6 3 1 1 4 4 4 0 Putative toxin 54 SAM_2 PF07647.12 KOO25563.1 - 0.033 14.0 0.0 6.7 6.6 0.0 3.4 2 2 0 2 2 2 0 SAM domain (Sterile alpha motif) SAP PF02037.22 KOO25563.1 - 0.054 13.0 0.0 33 4.1 0.0 4.3 5 0 0 5 5 5 0 SAP domain Clp_N PF02861.15 KOO25563.1 - 0.37 10.7 2.4 7 6.6 0.0 3.2 4 1 1 5 5 5 0 Clp amino terminal domain DUF2639 PF11121.3 KOO25563.1 - 1.2 8.7 4.7 3.7 7.1 0.0 3.6 4 1 0 4 4 4 0 Protein of unknown function (DUF2639) LRR_4 PF12799.2 KOO25564.1 - 2.7e-21 74.7 59.0 5.4e-07 29.0 2.3 15.8 13 4 5 19 19 19 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO25564.1 - 3.1e-14 50.8 37.2 0.48 10.6 0.1 17.9 21 1 0 21 21 21 6 Leucine Rich Repeat LRR_6 PF13516.1 KOO25564.1 - 1.9e-13 48.9 60.7 0.55 10.4 0.0 21.0 25 0 0 25 25 25 6 Leucine Rich repeat LRR_8 PF13855.1 KOO25564.1 - 1.4e-12 47.1 47.7 6.9e-06 25.7 1.3 11.9 13 2 3 16 16 16 4 Leucine rich repeat LRR_7 PF13504.1 KOO25564.1 - 0.014 15.4 55.4 11 6.7 0.1 17.7 21 1 0 21 21 21 0 Leucine rich repeat Abhydrolase_5 PF12695.2 KOO25565.1 - 0.0041 16.8 0.1 0.01 15.5 0.1 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Profilin PF00235.14 KOO25566.1 - 1e-18 67.5 0.5 1.7e-10 41.0 0.0 2.0 2 0 0 2 2 2 2 Profilin DUF3533 PF12051.3 KOO25567.1 - 0.066 11.9 0.7 0.098 11.3 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) FtsJ PF01728.14 KOO25568.1 - 4.2e-53 180.0 0.0 6.3e-53 179.4 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.3 KOO25568.1 - 1.2e-27 96.3 4.5 1.2e-27 96.3 3.1 3.3 3 0 0 3 3 3 2 Domain of unknown function (DUF3381) Myc_N PF01056.13 KOO25568.1 - 0.079 12.1 4.4 0.3 10.1 0.9 2.5 2 0 0 2 2 2 0 Myc amino-terminal region MRC1 PF09444.5 KOO25568.1 - 0.13 12.5 24.4 0.49 10.7 4.6 3.5 3 0 0 3 3 3 0 MRC1-like domain SHIPPO-rpt PF07004.7 KOO25570.1 - 0.0002 22.0 26.3 2.6 9.1 0.1 6.8 6 1 0 6 6 6 5 Sperm-tail PG-rich repeat ECR1_N PF14382.1 KOO25570.1 - 0.83 8.9 3.6 49 3.3 0.0 4.0 5 0 0 5 5 5 0 Exosome complex exonuclease RRP4 N-terminal region GST_N_3 PF13417.1 KOO25571.1 - 1.3e-10 41.3 0.0 2.3e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 KOO25571.1 - 1.5e-08 35.0 0.0 2.3e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.19 KOO25571.1 - 2.8e-08 33.5 0.1 5.2e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin GST_N_2 PF13409.1 KOO25571.1 - 3.6e-05 23.6 0.0 6.6e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KOO25571.1 - 3.8e-05 23.4 0.0 9.8e-05 22.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 KOO25571.1 - 0.0038 17.1 0.0 0.0074 16.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Pkinase PF00069.20 KOO25572.1 - 1.8e-54 184.5 0.0 2.1e-54 184.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25572.1 - 1.5e-46 158.6 0.0 1.9e-46 158.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO25572.1 - 2e-05 24.4 2.7 0.009 15.7 0.4 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO25572.1 - 0.0046 15.9 0.0 0.16 10.8 0.0 2.1 2 0 0 2 2 2 2 Kinase-like DPPIV_N PF00930.16 KOO25576.1 - 3.3e-66 223.2 0.0 3.9e-64 216.4 0.0 2.3 2 1 0 2 2 2 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.16 KOO25576.1 - 2.2e-53 180.6 0.0 6.4e-53 179.1 0.0 1.8 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.13 KOO25576.1 - 2.2e-12 46.9 0.2 1.3e-10 41.1 0.2 2.5 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_5 PF12695.2 KOO25576.1 - 5.2e-08 32.7 0.1 1.7e-07 31.0 0.0 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO25576.1 - 2.1e-06 27.7 0.9 2.2e-05 24.4 0.3 2.7 2 1 0 2 2 2 1 Alpha/beta hydrolase family DUF2048 PF09752.4 KOO25576.1 - 0.00048 19.1 0.1 0.0008 18.3 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2048) Abhydrolase_1 PF00561.15 KOO25576.1 - 0.0041 16.7 0.0 0.0074 15.8 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.13 KOO25576.1 - 0.0065 15.7 0.0 0.019 14.2 0.0 1.7 1 1 0 1 1 1 1 Dienelactone hydrolase family Esterase PF00756.15 KOO25576.1 - 0.029 13.8 0.0 0.049 13.0 0.0 1.3 1 0 0 1 1 1 0 Putative esterase DUF3141 PF11339.3 KOO25576.1 - 0.084 11.2 0.3 0.13 10.5 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) BAAT_C PF08840.6 KOO25576.1 - 0.13 11.9 0.1 3.4 7.3 0.0 2.4 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S28 PF05577.7 KOO25576.1 - 0.2 10.1 0.1 0.3 9.6 0.1 1.1 1 0 0 1 1 1 0 Serine carboxypeptidase S28 EF-hand_7 PF13499.1 KOO25577.1 - 3.5e-20 71.8 9.4 3.6e-07 30.2 0.0 3.8 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO25577.1 - 1.1e-18 65.3 19.9 8.3e-06 25.2 0.0 6.8 7 0 0 7 7 7 5 EF-hand domain EF-hand_1 PF00036.27 KOO25577.1 - 1.6e-17 61.4 12.3 0.00015 20.7 0.0 6.2 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.1 KOO25577.1 - 7.9e-15 54.2 9.3 1.3e-07 31.1 0.1 4.9 5 0 0 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO25577.1 - 6.4e-13 47.3 14.5 0.0013 18.0 0.1 6.1 6 0 0 6 6 6 3 EF hand SPARC_Ca_bdg PF10591.4 KOO25577.1 - 9.7e-06 25.5 0.4 0.16 12.0 0.0 4.0 3 1 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO25577.1 - 0.35 10.6 2.6 3.5 7.4 0.1 3.1 3 0 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand Ribonuc_L-PSP PF01042.16 KOO25578.1 - 2.4e-26 91.8 0.0 3.1e-26 91.5 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP EF-hand_7 PF13499.1 KOO25580.1 - 6.7e-21 74.1 2.7 7.4e-08 32.4 0.1 5.7 4 2 1 5 5 5 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO25580.1 - 2.1e-14 52.0 11.4 0.0003 20.4 0.0 6.0 7 0 0 7 7 7 3 EF-hand domain EF-hand_1 PF00036.27 KOO25580.1 - 2.4e-13 48.3 12.2 0.00019 20.4 0.4 6.0 7 0 0 7 7 7 3 EF hand EF-hand_5 PF13202.1 KOO25580.1 - 2.7e-13 48.5 4.1 5.6e-06 25.4 0.2 4.5 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.1 KOO25580.1 - 7.7e-10 38.2 7.9 0.14 11.7 0.0 5.3 4 1 1 5 5 5 4 EF-hand domain pair EF-hand_1 PF00036.27 KOO25582.1 - 7.7e-26 87.3 3.8 2.6e-05 23.1 0.0 4.7 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.1 KOO25582.1 - 2.2e-25 86.2 4.0 6.3e-06 25.6 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO25582.1 - 8e-25 86.7 4.1 1.9e-09 37.5 0.0 3.3 1 1 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO25582.1 - 6.6e-19 66.3 14.2 2.8e-06 26.4 0.1 5.0 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.1 KOO25582.1 - 1.9e-18 65.8 0.4 0.0005 19.6 0.0 4.4 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.1 KOO25582.1 - 0.011 15.6 0.0 0.35 10.8 0.0 2.7 3 0 0 3 3 3 0 EF-hand domain EF-hand_10 PF14788.1 KOO25582.1 - 0.12 12.0 1.4 6.4 6.5 0.0 3.4 5 0 0 5 5 5 0 EF hand Peptidase_M17 PF00883.16 KOO25583.1 - 2e-51 174.7 0.1 3.6e-51 173.8 0.0 1.3 1 1 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain AdoMet_MTase PF07757.8 KOO25583.1 - 0.055 13.5 0.7 0.098 12.7 0.5 1.4 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase PAS_9 PF13426.1 KOO25584.1 - 1.8e-08 34.7 0.0 2.4e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 PAS domain Homeobox PF00046.24 KOO25584.1 - 0.013 15.0 0.0 0.16 11.5 0.0 2.3 2 0 0 2 2 2 0 Homeobox domain Phage_portal PF04860.7 KOO25584.1 - 0.036 12.7 0.0 0.051 12.2 0.0 1.1 1 0 0 1 1 1 0 Phage portal protein Thr_synth_N PF14821.1 KOO25585.1 - 6.6e-17 61.2 0.0 1.2e-16 60.4 0.0 1.4 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.20 KOO25585.1 - 5e-14 52.2 0.4 1e-13 51.1 0.0 1.6 2 1 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Isochorismatase PF00857.15 KOO25586.1 - 5.9e-27 94.7 0.4 9.6e-27 94.0 0.3 1.3 1 1 0 1 1 1 1 Isochorismatase family NAD_binding_11 PF14833.1 KOO25588.1 - 9.4e-35 119.3 0.1 1.5e-34 118.7 0.1 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.10 KOO25588.1 - 1.2e-26 93.4 0.1 2e-26 92.8 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Cpn10 PF00166.16 KOO25590.1 - 4.2e-14 52.2 0.0 6.2e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit WD40 PF00400.27 KOO25591.1 - 3.3e-22 77.4 20.6 2.9e-06 26.9 1.2 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat DUF4613 PF15390.1 KOO25591.1 - 0.043 12.0 1.7 0.061 11.5 1.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) DUF4558 PF15104.1 KOO25591.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4558) PQQ_3 PF13570.1 KOO25591.1 - 0.71 10.2 4.9 1.1 9.6 0.2 3.4 3 1 1 4 4 4 0 PQQ-like domain AP2 PF00847.15 KOO25592.1 - 0.00027 21.0 0.1 0.00058 19.9 0.0 1.6 1 0 0 1 1 1 1 AP2 domain PHY PF00360.15 KOO25592.1 - 0.0076 15.4 0.3 0.073 12.2 0.0 2.1 1 1 1 2 2 2 2 Phytochrome region Glyco_hydro_42 PF02449.10 KOO25593.1 - 8.5e-05 21.8 0.0 0.00014 21.0 0.0 1.3 1 0 0 1 1 1 1 Beta-galactosidase KMP11 PF03037.11 KOO25593.1 - 0.13 12.8 0.1 0.26 11.9 0.1 1.4 1 0 0 1 1 1 0 Kinetoplastid membrane protein 11 CH PF00307.26 KOO25594.1 - 1.3e-08 34.7 0.0 8.6e-07 28.9 0.0 2.5 2 1 0 2 2 2 2 Calponin homology (CH) domain MIP PF00230.15 KOO25595.1 - 1.3e-44 152.3 78.3 4.4e-15 55.7 2.8 5.8 4 3 0 4 4 4 4 Major intrinsic protein Ank_2 PF12796.2 KOO25596.1 - 6.3e-19 68.1 0.5 3.3e-09 36.9 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO25596.1 - 3.7e-16 58.7 2.7 6.4e-07 29.4 0.0 4.0 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO25596.1 - 8e-16 56.9 1.8 3.4e-07 29.7 0.1 4.6 5 0 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.1 KOO25596.1 - 5.2e-14 50.9 1.1 1.3e-05 24.9 0.0 4.9 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.1 KOO25596.1 - 4.1e-12 46.2 0.0 1.8e-08 34.6 0.0 3.6 2 2 3 5 5 5 3 Ankyrin repeats (many copies) Peripla_BP_1 PF00532.16 KOO25596.1 - 0.062 12.4 0.3 0.095 11.8 0.2 1.2 1 0 0 1 1 1 0 Periplasmic binding proteins and sugar binding domain of LacI family NESP55 PF06390.7 KOO25597.1 - 3 7.1 9.4 0.085 12.2 0.6 2.2 2 1 0 2 2 2 0 Neuroendocrine-specific golgi protein P55 (NESP55) DUF4200 PF13863.1 KOO25599.1 - 3.8e-32 110.8 28.2 3.8e-32 110.8 19.6 5.3 4 1 1 5 5 5 3 Domain of unknown function (DUF4200) Baculo_PEP_C PF04513.7 KOO25599.1 - 0.013 15.3 2.1 1.4 8.7 0.3 2.9 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3573 PF12097.3 KOO25599.1 - 0.19 10.2 2.5 0.47 9.0 1.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) TPR_12 PF13424.1 KOO25600.1 - 1.5e-83 274.7 34.7 8.2e-20 70.5 0.3 6.2 2 1 5 7 7 7 6 Tetratricopeptide repeat TPR_10 PF13374.1 KOO25600.1 - 5.2e-71 232.7 49.4 2.8e-13 49.3 0.3 8.6 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_1 PF00515.23 KOO25600.1 - 2.5e-21 74.3 8.5 0.0048 16.4 0.0 6.5 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.12 KOO25600.1 - 9.1e-19 65.8 15.5 0.078 12.9 0.0 7.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_16 PF13432.1 KOO25600.1 - 8.1e-17 61.4 21.5 0.00063 20.3 0.6 6.6 1 1 5 6 6 6 5 Tetratricopeptide repeat TPR_4 PF07721.9 KOO25600.1 - 2.1e-16 58.5 29.7 0.016 15.6 0.2 9.3 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_17 PF13431.1 KOO25600.1 - 6.1e-16 57.2 6.1 0.48 10.7 0.0 7.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.1 KOO25600.1 - 1.4e-12 46.4 3.8 0.42 10.4 0.0 6.9 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO25600.1 - 1.2e-11 44.0 8.3 0.0013 18.3 0.1 4.1 2 1 3 5 5 5 4 TPR repeat Osmo_CC PF08946.5 KOO25600.1 - 2.7e-11 43.2 4.5 0.61 10.1 0.0 7.0 7 0 0 7 7 7 4 Osmosensory transporter coiled coil TPR_19 PF14559.1 KOO25600.1 - 3.2e-11 43.4 19.3 0.0081 16.4 0.6 5.1 3 1 2 5 5 5 5 Tetratricopeptide repeat TPR_7 PF13176.1 KOO25600.1 - 1e-09 37.4 23.5 0.16 11.8 0.1 6.9 7 0 0 7 7 7 5 Tetratricopeptide repeat ApoLp-III PF07464.6 KOO25600.1 - 3e-07 30.5 0.3 11 5.9 0.0 5.8 2 1 4 6 6 6 0 Apolipophorin-III precursor (apoLp-III) HisKA_3 PF07730.8 KOO25600.1 - 1.5e-05 25.2 19.6 0.84 10.0 0.1 6.8 6 1 2 8 8 8 2 Histidine kinase TPR_14 PF13428.1 KOO25600.1 - 0.00043 20.6 41.0 2.2 9.1 0.4 8.1 3 1 5 8 8 8 1 Tetratricopeptide repeat TPR_3 PF07720.7 KOO25600.1 - 0.0077 16.0 0.0 24 4.8 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF4145 PF13643.1 KOO25600.1 - 0.027 14.3 1.4 9 6.2 0.0 4.1 1 1 4 5 5 5 0 Domain of unknown function (DUF4145) APG17 PF04108.7 KOO25600.1 - 0.14 10.9 0.1 10 4.7 0.0 2.4 2 1 0 2 2 2 0 Autophagy protein Apg17 Calpain_inhib PF00748.14 KOO25600.1 - 1.3 9.3 10.6 41 4.5 0.1 5.1 6 0 0 6 6 5 0 Calpain inhibitor Galactosyl_T PF01762.16 KOO25601.1 - 3.4e-09 36.5 0.0 1.4e-08 34.5 0.0 2.1 1 1 0 1 1 1 1 Galactosyltransferase Kelch_3 PF13415.1 KOO25603.1 - 4.7e-14 52.0 6.5 0.00084 19.4 0.0 6.2 5 0 0 5 5 5 2 Galactose oxidase, central domain EF-hand_1 PF00036.27 KOO25603.1 - 1.1e-13 49.4 0.3 0.00087 18.4 0.0 3.6 3 0 0 3 3 3 3 EF hand Kelch_5 PF13854.1 KOO25603.1 - 3e-12 46.1 1.3 0.03 14.2 0.0 5.8 6 0 0 6 6 6 3 Kelch motif EF-hand_7 PF13499.1 KOO25603.1 - 3.6e-12 46.2 0.0 6.1e-07 29.4 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO25603.1 - 3e-11 42.7 2.1 0.00017 21.1 0.0 3.5 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO25603.1 - 3.3e-10 38.9 1.0 0.0099 15.6 0.0 4.1 4 0 0 4 4 4 2 EF-hand domain Nse4_C PF08743.5 KOO25603.1 - 6.8e-10 38.8 0.1 1.4e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Nse4 C-terminal EF-hand_5 PF13202.1 KOO25603.1 - 2e-09 36.3 0.6 0.00087 18.5 0.1 3.6 3 0 0 3 3 3 2 EF hand Kelch_4 PF13418.1 KOO25603.1 - 2.6e-07 30.2 10.1 0.0028 17.4 0.0 6.7 5 2 1 6 6 6 1 Galactose oxidase, central domain LRR_4 PF12799.2 KOO25603.1 - 0.00046 19.7 1.9 0.0023 17.5 0.2 2.6 2 1 1 3 3 3 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO25603.1 - 0.003 17.2 0.8 0.0078 15.9 0.2 2.0 2 0 0 2 2 2 1 Leucine rich repeat Kelch_6 PF13964.1 KOO25603.1 - 0.013 15.6 0.0 28 5.0 0.0 4.4 5 0 0 5 5 4 0 Kelch motif LRR_1 PF00560.28 KOO25603.1 - 0.078 13.0 1.7 39 4.8 0.1 3.7 3 0 0 3 3 3 0 Leucine Rich Repeat TIG PF01833.19 KOO25603.1 - 0.1 12.5 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 IPT/TIG domain LRR_7 PF13504.1 KOO25603.1 - 0.25 11.7 6.3 9.2 6.9 0.0 4.4 4 0 0 4 4 3 0 Leucine rich repeat RAG2 PF03089.9 KOO25603.1 - 1.3 7.6 0.0 15 4.2 0.0 2.3 2 1 0 2 2 2 0 Recombination activating protein 2 PQ-loop PF04193.9 KOO25604.1 - 4e-07 29.4 1.1 9.9e-07 28.2 0.8 1.8 1 0 0 1 1 1 1 PQ loop repeat HECT PF00632.20 KOO25604.1 - 1.8e-06 27.3 0.0 2.9e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) MtN3_slv PF03083.11 KOO25604.1 - 9e-06 25.4 3.7 1.7e-05 24.5 2.5 1.4 1 0 0 1 1 1 1 Sugar efflux transporter for intercellular exchange UQ_con PF00179.21 KOO25605.1 - 4.4e-13 48.8 0.0 5.9e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 KOO25605.1 - 0.046 13.6 0.0 0.058 13.2 0.0 1.2 1 0 0 1 1 1 0 RWD domain SAGA-Tad1 PF12767.2 KOO25607.1 - 1.4e-13 51.1 0.0 1.5e-13 51.0 0.0 1.0 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit NIF PF03031.13 KOO25608.1 - 4.9e-38 130.3 0.1 6.5e-38 129.8 0.1 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase zf-HYPF PF07503.7 KOO25609.1 - 0.0092 15.3 13.3 4.7 6.7 0.1 4.8 4 0 0 4 4 4 4 HypF finger Phenol_MetA_deg PF13557.1 KOO25609.1 - 2.2 7.9 5.8 0.67 9.7 0.5 2.1 2 0 0 2 2 2 0 Putative MetA-pathway of phenol degradation SIR2 PF02146.12 KOO25610.1 - 1.5e-25 89.9 0.0 1.8e-25 89.6 0.0 1.1 1 0 0 1 1 1 1 Sir2 family Pentapeptide_4 PF13599.1 KOO25611.1 - 1.1e-23 82.8 0.0 0.00014 21.6 0.0 7.1 4 2 3 7 7 7 6 Pentapeptide repeats (9 copies) EF-hand_1 PF00036.27 KOO25611.1 - 3.9e-21 72.6 6.3 0.00019 20.4 0.0 5.0 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO25611.1 - 1.6e-17 63.3 0.4 1.6e-07 31.3 0.4 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO25611.1 - 6.6e-16 56.7 7.7 0.00092 18.9 0.0 5.7 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.1 KOO25611.1 - 5.3e-11 41.9 3.3 0.0024 17.4 0.1 5.1 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO25611.1 - 1.5e-10 39.9 5.8 0.06 12.7 0.0 5.2 4 0 0 4 4 4 4 EF hand Caleosin PF05042.8 KOO25611.1 - 0.0071 15.9 0.0 0.026 14.0 0.0 1.9 2 0 0 2 2 2 1 Caleosin related protein SinI PF08671.5 KOO25611.1 - 0.008 15.5 0.2 0.031 13.7 0.1 2.1 1 0 0 1 1 1 1 Anti-repressor SinI EF-hand_10 PF14788.1 KOO25611.1 - 0.03 14.0 0.3 11 5.7 0.2 2.9 2 0 0 2 2 2 0 EF hand SPARC_Ca_bdg PF10591.4 KOO25611.1 - 0.14 12.2 0.0 0.48 10.4 0.0 2.0 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region FliD_N PF02465.13 KOO25611.1 - 0.2 12.0 2.8 7.1 7.0 0.1 3.1 3 0 0 3 3 2 0 Flagellar hook-associated protein 2 N-terminus EF-hand_1 PF00036.27 KOO25612.1 - 3.2e-25 85.4 2.1 9.6e-07 27.6 0.2 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO25612.1 - 1.2e-23 80.8 1.6 7.6e-07 28.5 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO25612.1 - 5.9e-22 77.5 0.1 1.4e-12 47.5 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO25612.1 - 1.1e-18 66.5 4.6 1.1e-07 31.3 0.1 4.0 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO25612.1 - 1.9e-18 64.8 6.1 3.1e-05 23.1 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_4 PF12763.2 KOO25612.1 - 1.8e-05 24.4 0.1 0.2 11.4 0.0 2.9 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO25612.1 - 0.0005 19.9 0.0 0.23 11.3 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_like PF09279.6 KOO25612.1 - 0.0019 18.2 5.3 0.68 10.0 0.0 3.5 3 0 0 3 3 3 2 Phosphoinositide-specific phospholipase C, efhand-like DUF2284 PF10050.4 KOO25612.1 - 0.2 11.2 1.7 0.4 10.2 1.2 1.4 1 0 0 1 1 1 0 Predicted metal-binding protein (DUF2284) CorA PF01544.13 KOO25612.1 - 0.56 9.1 3.0 1.4 7.8 2.1 1.6 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein zf-C2HC PF01530.13 KOO25613.1 - 0.0041 16.8 2.3 0.2 11.4 0.1 2.3 2 0 0 2 2 2 2 Zinc finger, C2HC type Mito_fiss_reg PF05308.6 KOO25613.1 - 0.17 11.2 3.5 0.28 10.5 2.4 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator SKG6 PF08693.5 KOO25613.1 - 0.4 10.0 6.1 0.85 8.9 4.2 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain CAP_N PF01213.14 KOO25613.1 - 7 5.8 6.8 12 5.1 4.7 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DUF1777 PF08648.7 KOO25614.1 - 0.51 10.0 19.4 2.4 7.8 8.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1777) Med8 PF10232.4 KOO25614.1 - 1.2 8.6 9.6 2.6 7.4 3.4 2.0 2 0 0 2 2 2 0 Mediator of RNA polymerase II transcription complex subunit 8 Spore_coat_CotO PF14153.1 KOO25614.1 - 9.8 5.5 17.4 6.4 6.1 6.8 2.1 2 0 0 2 2 2 0 Spore coat protein CotO TPR_12 PF13424.1 KOO25615.1 - 9.2e-26 89.6 6.5 3.4e-14 52.5 0.1 3.1 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.1 KOO25615.1 - 1e-20 72.9 4.8 2e-08 33.8 0.4 3.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO25615.1 - 0.00061 19.2 0.1 0.48 10.1 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO25615.1 - 0.0012 18.5 0.5 0.25 11.3 0.0 3.9 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOO25615.1 - 0.002 17.7 0.0 0.029 14.0 0.0 2.4 2 0 0 2 2 2 1 TPR repeat TPR_14 PF13428.1 KOO25615.1 - 0.0053 17.2 5.9 18 6.3 0.2 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO25615.1 - 0.006 16.2 1.6 0.13 12.1 0.1 3.5 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO25615.1 - 0.0061 16.6 0.0 4.7 7.6 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO25615.1 - 0.0063 17.1 5.2 0.097 13.3 0.0 2.8 2 1 0 2 2 2 1 Tetratricopeptide repeat Uso1_p115_C PF04871.8 KOO25616.1 - 0.11 12.4 5.5 0.16 11.9 3.8 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region ADIP PF11559.3 KOO25616.1 - 0.17 11.8 7.2 0.25 11.2 5.0 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF972 PF06156.8 KOO25616.1 - 0.26 11.6 4.9 0.38 11.1 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF972) APG6 PF04111.7 KOO25616.1 - 1.7 7.6 7.0 2 7.3 4.9 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DivIC PF04977.10 KOO25616.1 - 4.2 6.9 10.2 29 4.2 6.4 2.2 1 1 1 2 2 2 0 Septum formation initiator MMS19_N PF14500.1 KOO25617.1 - 7.7e-41 140.0 0.0 3.7e-40 137.8 0.0 2.0 3 0 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II UVR PF02151.14 KOO25617.1 - 0.0025 17.2 3.1 0.005 16.3 2.2 1.5 1 0 0 1 1 1 1 UvrB/uvrC motif EF-hand_7 PF13499.1 KOO25618.1 - 8.2e-25 86.7 0.0 2.1e-08 34.1 0.0 4.2 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.27 KOO25618.1 - 3.3e-24 82.2 0.9 7.4e-05 21.7 0.2 5.7 5 0 0 5 5 5 5 EF hand EF-hand_6 PF13405.1 KOO25618.1 - 2.4e-18 64.2 0.2 0.0097 15.7 0.0 6.4 6 0 0 6 6 6 4 EF-hand domain EF-hand_8 PF13833.1 KOO25618.1 - 2.5e-15 55.8 4.0 1.4e-05 24.6 0.0 5.7 4 2 1 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.1 KOO25618.1 - 3.1e-13 48.4 0.6 0.00031 19.9 0.0 5.7 6 0 0 6 6 6 4 EF hand TerB PF05099.8 KOO25618.1 - 0.019 14.7 0.0 0.051 13.3 0.0 1.7 2 0 0 2 2 2 0 Tellurite resistance protein TerB Vps23_core PF09454.5 KOO25618.1 - 0.1 12.2 0.0 4.4 6.9 0.0 2.5 2 0 0 2 2 2 0 Vps23 core domain B9-C2 PF07162.6 KOO25620.1 - 1.7e-29 102.7 0.0 2.6e-29 102.1 0.0 1.3 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein PP1c_bdg PF10488.4 KOO25620.1 - 0.16 11.1 1.0 0.26 10.4 0.7 1.2 1 0 0 1 1 1 0 Phosphatase-1 catalytic subunit binding region TPR_11 PF13414.1 KOO25622.1 - 1.1e-18 66.6 5.5 2.6e-12 46.1 0.2 2.7 1 1 2 3 3 3 3 TPR repeat TPR_1 PF00515.23 KOO25622.1 - 1.9e-13 49.4 3.0 0.00011 21.6 0.0 4.0 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO25622.1 - 2e-09 37.8 4.7 7.4e-05 23.3 0.1 3.6 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO25622.1 - 3.6e-09 35.8 16.8 0.00047 19.8 0.7 5.0 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOO25622.1 - 1e-07 32.1 4.1 0.0001 22.5 0.1 2.9 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO25622.1 - 9.1e-06 25.4 0.6 0.0065 16.3 0.0 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO25622.1 - 1.4e-05 25.2 12.1 0.016 15.8 0.0 4.4 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO25622.1 - 1.5e-05 24.3 12.1 0.0094 15.6 0.6 4.8 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO25622.1 - 0.00031 20.3 0.6 0.78 9.6 0.0 3.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO25622.1 - 0.00042 20.3 1.6 0.0011 18.9 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOO25622.1 - 0.0034 17.2 8.0 0.004 17.0 0.1 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 KOO25622.1 - 0.099 13.1 14.6 4.3 8.0 0.0 5.2 4 2 0 4 4 4 0 Tetratricopeptide repeat Zip PF02535.17 KOO25622.1 - 0.3 10.0 14.8 0.48 9.3 10.3 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter DUF1538 PF07556.6 KOO25623.1 - 4.9e-85 283.9 28.3 1.9e-43 147.9 3.8 3.2 3 1 0 3 3 3 2 Protein of unknown function (DUF1538) C2 PF00168.25 KOO25624.1 - 9.4e-43 143.9 0.0 6.9e-15 54.6 0.0 3.4 3 0 0 3 3 3 3 C2 domain EF-hand_7 PF13499.1 KOO25624.1 - 1.5e-14 53.8 0.5 3.2e-08 33.5 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO25624.1 - 1.8e-13 49.1 0.7 0.00011 21.7 0.0 4.1 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.27 KOO25624.1 - 2.2e-11 42.2 0.0 8.4e-05 21.6 0.0 4.0 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.1 KOO25624.1 - 4.1e-11 41.6 0.2 0.00088 18.5 0.0 3.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO25624.1 - 3e-06 26.7 0.0 0.13 11.8 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain pair NT-C2 PF10358.4 KOO25624.1 - 0.14 11.6 0.0 2.2 7.7 0.0 2.5 3 0 0 3 3 3 0 N-terminal C2 in EEIG1 and EHBP1 proteins Pkinase PF00069.20 KOO25625.1 - 5.4e-40 137.1 0.0 8.6e-40 136.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25625.1 - 1.6e-22 79.8 0.0 2.6e-22 79.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4470 PF14737.1 KOO25625.1 - 5.1e-11 42.2 0.0 1.4e-10 40.7 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) PARP PF00644.15 KOO25625.1 - 2.9e-09 36.6 0.0 5e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain TPR_11 PF13414.1 KOO25625.1 - 4.3e-09 35.8 6.5 1.1e-05 24.9 0.2 2.6 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 KOO25625.1 - 1.4e-06 27.6 9.9 0.0003 20.2 2.2 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat APH PF01636.18 KOO25625.1 - 7e-05 22.6 0.0 0.00048 19.9 0.0 2.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family TPR_2 PF07719.12 KOO25625.1 - 0.00011 21.8 12.9 0.0021 17.8 2.5 3.4 4 0 0 4 4 2 2 Tetratricopeptide repeat Kinase-like PF14531.1 KOO25625.1 - 0.00052 19.0 0.0 0.00086 18.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like TPR_8 PF13181.1 KOO25625.1 - 0.0016 18.0 0.6 0.0063 16.2 0.3 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO25625.1 - 0.005 17.4 8.9 6.2 7.6 0.7 4.6 2 1 1 3 3 3 1 Tetratricopeptide repeat Kdo PF06293.9 KOO25625.1 - 0.0073 15.3 0.0 0.016 14.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2680 PF10925.3 KOO25625.1 - 0.012 15.4 0.3 3.6 7.5 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2680) TPR_12 PF13424.1 KOO25625.1 - 0.025 14.4 3.8 0.032 14.1 0.7 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO25625.1 - 0.063 13.1 0.5 0.31 10.9 0.2 2.3 2 0 0 2 2 1 0 Tetratricopeptide repeat Phage_XkdX PF09693.5 KOO25625.1 - 0.52 9.8 0.0 21 4.7 0.0 2.9 3 0 0 3 3 3 0 Phage uncharacterised protein (Phage_XkdX) Nop PF01798.13 KOO25626.1 - 0.17 11.1 3.6 0.57 9.4 2.5 1.9 1 1 0 1 1 1 0 Putative snoRNA binding domain CotH PF08757.6 KOO25626.1 - 0.52 9.5 2.3 0.4 9.8 0.5 1.5 2 0 0 2 2 2 0 CotH protein DUF4446 PF14584.1 KOO25626.1 - 0.88 9.3 4.7 1.5 8.5 1.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Peptidase_M10 PF00413.19 KOO25627.1 - 0.0002 21.1 0.0 0.03 14.0 0.0 2.4 2 0 0 2 2 2 2 Matrixin Sarcoglycan_2 PF05510.8 KOO25627.1 - 0.043 12.1 0.1 0.073 11.3 0.1 1.3 1 0 0 1 1 1 0 Sarcoglycan alpha/epsilon PI31_Prot_C PF08577.6 KOO25627.1 - 0.095 13.3 1.4 0.22 12.1 1.0 1.6 1 0 0 1 1 1 0 PI31 proteasome regulator Peripla_BP_6 PF13458.1 KOO25629.1 - 3.9e-06 26.4 0.2 6.8e-06 25.6 0.1 1.3 1 0 0 1 1 1 1 Periplasmic binding protein EGF_2 PF07974.8 KOO25629.1 - 0.00017 21.6 10.1 0.00017 21.6 7.0 1.8 2 0 0 2 2 2 1 EGF-like domain hEGF PF12661.2 KOO25629.1 - 0.00078 19.3 2.9 0.0022 17.9 2.0 1.8 1 0 0 1 1 1 1 Human growth factor-like EGF EGF PF00008.22 KOO25629.1 - 0.17 11.8 9.3 0.024 14.5 3.0 2.0 2 0 0 2 2 2 0 EGF-like domain Laminin_EGF PF00053.19 KOO25629.1 - 0.27 11.2 8.5 0.048 13.5 2.9 2.0 2 0 0 2 2 2 0 Laminin EGF-like (Domains III and V) EB PF01683.13 KOO25629.1 - 0.9 9.6 6.7 2.6 8.1 4.7 1.7 1 0 0 1 1 1 0 EB module Lactamase_B_2 PF12706.2 KOO25630.1 - 9.7e-09 35.0 0.0 2e-08 34.0 0.0 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 KOO25630.1 - 1.3e-07 31.4 0.7 2.6e-07 30.5 0.5 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily DUF217 PF02697.9 KOO25631.1 - 0.025 14.8 0.0 0.19 12.0 0.0 2.6 1 0 0 1 1 1 0 Uncharacterized ACR, COG1753 FISNA PF14484.1 KOO25631.1 - 0.24 11.4 2.7 0.34 10.9 0.4 2.4 2 0 0 2 2 2 0 Fish-specific NACHT associated domain Atg14 PF10186.4 KOO25631.1 - 4.4 6.1 37.2 0.18 10.6 5.2 3.9 3 1 1 4 4 4 0 UV radiation resistance protein and autophagy-related subunit 14 GAS PF13851.1 KOO25631.1 - 5 6.2 49.0 1.2 8.3 9.0 5.2 4 2 1 5 5 5 0 Growth-arrest specific micro-tubule binding Kinetocho_Slk19 PF12709.2 KOO25631.1 - 9.2 6.4 22.3 0.14 12.2 4.0 5.0 3 2 2 5 5 5 0 Central kinetochore-associated PAS_4 PF08448.5 KOO25632.1 - 3e-23 81.9 0.3 1.8e-14 53.7 0.1 2.4 2 0 0 2 2 2 2 PAS fold PAS PF00989.19 KOO25632.1 - 9.7e-22 76.8 0.1 1.7e-17 63.2 0.1 2.3 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.1 KOO25632.1 - 2.4e-21 76.0 0.0 2.1e-13 50.5 0.1 2.4 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.6 KOO25632.1 - 5.4e-14 52.0 0.0 6.6e-06 26.1 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_8 PF13188.1 KOO25632.1 - 7.8e-06 25.5 0.0 0.00013 21.6 0.0 2.5 2 0 0 2 2 2 1 PAS domain PAS_10 PF13596.1 KOO25632.1 - 0.00029 21.0 0.0 0.00097 19.3 0.0 1.8 2 0 0 2 2 2 1 PAS domain Tom22 PF04281.8 KOO25633.1 - 0.013 15.0 0.4 0.02 14.4 0.3 1.3 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 Prothymosin PF03247.9 KOO25633.1 - 0.043 13.9 7.1 0.075 13.1 4.9 1.3 1 0 0 1 1 1 0 Prothymosin/parathymosin family Nucleoplasmin PF03066.10 KOO25633.1 - 0.12 11.8 3.4 0.19 11.2 2.4 1.2 1 0 0 1 1 1 0 Nucleoplasmin Pkinase PF00069.20 KOO25634.1 - 0.01 14.9 0.0 0.013 14.6 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain DUF3262 PF11660.3 KOO25634.1 - 0.051 13.6 0.0 0.077 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3262) Sec7 PF01369.15 KOO25635.1 - 7.9e-63 211.5 0.0 1.2e-62 210.9 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain Fer2_4 PF13510.1 KOO25636.1 - 3.1e-10 39.7 0.4 7.6e-09 35.2 0.2 2.2 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain PDZ PF00595.19 KOO25636.1 - 9.8e-08 32.0 0.4 2.4e-07 30.8 0.1 1.8 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) Fer2 PF00111.22 KOO25636.1 - 3.7e-07 29.7 1.8 1.1e-06 28.2 1.3 1.8 1 1 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain PDZ_2 PF13180.1 KOO25636.1 - 0.00062 19.6 0.8 0.0019 18.0 0.2 2.1 2 0 0 2 2 2 1 PDZ domain Atx10homo_assoc PF09759.4 KOO25637.1 - 0.00014 21.5 3.1 0.2 11.4 0.0 4.8 4 2 1 5 5 5 1 Spinocerebellar ataxia type 10 protein domain Cnd1 PF12717.2 KOO25637.1 - 0.011 15.5 0.5 0.94 9.2 0.0 2.5 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Arm PF00514.18 KOO25637.1 - 0.052 13.3 23.7 1.7 8.5 0.1 8.9 11 1 1 12 12 12 0 Armadillo/beta-catenin-like repeat CBM_14 PF01607.19 KOO25638.1 - 0.031 14.1 0.4 0.056 13.3 0.3 1.5 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain FAM91_C PF14648.1 KOO25639.1 - 8.3e-85 285.2 0.0 2.9e-70 237.3 0.0 2.2 2 0 0 2 2 2 2 FAM91 C-terminus FAM91_N PF14647.1 KOO25639.1 - 2.3e-63 214.0 0.0 7e-37 127.1 0.0 2.7 3 0 0 3 3 3 2 FAM91 N-terminus Mito_carr PF00153.22 KOO25640.1 - 2.2e-39 133.0 6.5 4.3e-17 61.6 0.0 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein PAT1 PF09770.4 KOO25641.1 - 5.5 5.0 26.3 5.9 5.0 18.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PITH PF06201.8 KOO25642.1 - 3e-37 127.7 0.0 3.5e-37 127.5 0.0 1.0 1 0 0 1 1 1 1 PITH domain APC10 PF03256.11 KOO25642.1 - 0.014 14.9 0.0 0.026 14.1 0.0 1.4 1 1 0 1 1 1 0 Anaphase-promoting complex, subunit 10 (APC10) Abhydrolase_5 PF12695.2 KOO25643.1 - 5.8e-08 32.6 0.1 7.4e-08 32.2 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO25643.1 - 2.2e-05 24.4 0.3 0.09 12.6 0.0 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family DLH PF01738.13 KOO25643.1 - 0.0069 15.6 0.0 0.0078 15.5 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family PhoPQ_related PF10142.4 KOO25643.1 - 0.12 10.7 0.0 0.17 10.3 0.0 1.1 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein ATP-synt_C PF00137.16 KOO25644.1 - 1.4e-24 85.7 24.4 2.2e-12 46.6 7.5 2.4 2 0 0 2 2 2 2 ATP synthase subunit C zf-RING_2 PF13639.1 KOO25644.1 - 6.4e-08 32.3 4.3 1.7e-07 30.9 3.0 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 KOO25644.1 - 1.6e-07 31.1 2.3 1.6e-07 31.1 1.6 2.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO25644.1 - 1.1e-05 24.9 1.6 1.1e-05 24.9 1.1 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO25644.1 - 0.00047 19.7 2.6 0.00047 19.7 1.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Baculo_IE-1 PF05290.6 KOO25644.1 - 0.0017 18.0 0.2 0.003 17.2 0.2 1.3 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-RING_5 PF14634.1 KOO25644.1 - 0.0021 17.7 1.6 0.0021 17.7 1.1 2.2 2 1 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 KOO25644.1 - 0.0056 16.5 1.1 0.0056 16.5 0.7 2.0 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 KOO25644.1 - 0.011 15.3 0.2 0.025 14.3 0.1 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_4 PF14570.1 KOO25644.1 - 0.047 13.2 3.2 0.1 12.1 2.2 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.1 KOO25644.1 - 2.9 7.5 12.1 0.57 9.7 3.7 2.8 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 Trichoplein PF13868.1 KOO25646.1 - 1.8e-09 36.4 106.5 1.8e-09 36.4 73.8 2.0 2 0 0 2 2 2 2 Tumour suppressor, Mitostatin Pkinase PF00069.20 KOO25648.1 - 2.2e-59 200.7 0.0 3.3e-59 200.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.24 KOO25648.1 - 2e-42 142.8 0.1 1.7e-14 53.3 0.0 3.6 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.12 KOO25648.1 - 6.5e-26 90.9 0.0 1.2e-25 90.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO25648.1 - 0.015 14.2 0.1 0.048 12.6 0.0 1.8 2 0 0 2 2 2 0 Kinase-like APH PF01636.18 KOO25648.1 - 0.035 13.8 0.0 0.14 11.8 0.0 2.0 2 1 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 KOO25648.1 - 0.042 12.9 0.0 0.084 11.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 KOO25648.1 - 0.11 11.3 0.0 0.23 10.2 0.0 1.5 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase PF00069.20 KOO25649.1 - 2.2e-47 161.3 0.0 3e-47 160.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25649.1 - 4e-23 81.8 0.0 5.8e-23 81.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO25649.1 - 5.9e-06 25.4 0.3 0.004 16.1 0.1 2.9 2 1 0 2 2 2 2 Kinase-like Kdo PF06293.9 KOO25649.1 - 5.9e-05 22.2 0.0 0.0001 21.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family IQ PF00612.22 KOO25649.1 - 0.0035 16.8 0.3 0.0072 15.8 0.2 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif EZH2_WD-Binding PF11616.3 KOO25650.1 - 0.057 13.2 0.4 3.8 7.4 0.1 2.2 2 0 0 2 2 2 0 WD repeat binding protein EZH2 HAD PF12710.2 KOO25651.1 - 9.7e-16 58.4 0.0 1.2e-15 58.1 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Peptidase_M50B PF13398.1 KOO25651.1 - 0.091 12.1 0.4 0.15 11.4 0.2 1.3 1 0 0 1 1 1 0 Peptidase M50B-like Metallophos PF00149.23 KOO25652.1 - 2.7e-45 154.2 0.3 3.3e-45 153.9 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Arm PF00514.18 KOO25653.1 - 7.5e-16 57.3 18.3 1.7e-06 27.5 0.2 4.3 4 0 0 4 4 4 4 Armadillo/beta-catenin-like repeat TRL PF13146.1 KOO25653.1 - 2.3 8.2 6.5 3.4 7.7 0.2 2.9 2 1 1 3 3 3 0 TRL-like protein family HEAT_2 PF13646.1 KOO25653.1 - 2.3 8.5 21.8 2.2 8.6 11.4 2.7 1 1 0 2 2 2 0 HEAT repeats PABP PF00658.13 KOO25654.1 - 4.3e-28 96.7 0.4 4.9e-28 96.5 0.3 1.1 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain Pkinase PF00069.20 KOO25655.1 - 1.4e-68 230.8 0.0 1.8e-68 230.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25655.1 - 1.6e-33 115.8 0.1 1.5e-32 112.6 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO25655.1 - 6.4e-05 22.0 0.0 0.00026 20.0 0.0 1.9 1 1 1 2 2 2 1 Kinase-like APH PF01636.18 KOO25655.1 - 0.005 16.6 2.0 0.032 13.9 0.2 2.6 2 1 0 2 2 2 1 Phosphotransferase enzyme family Adeno_PIX PF03955.9 KOO25655.1 - 0.038 14.5 0.1 0.67 10.4 0.0 2.5 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) MDMPI_N PF11716.3 KOO25656.1 - 0.0043 17.4 3.4 0.0052 17.2 1.3 1.7 2 0 0 2 2 2 1 Mycothiol maleylpyruvate isomerase N-terminal domain Methyltransf_11 PF08241.7 KOO25657.1 - 1.1e-08 35.3 0.0 2.3e-08 34.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.11 KOO25657.1 - 4.8e-08 31.7 0.0 5.9e-08 31.5 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_23 PF13489.1 KOO25657.1 - 7.5e-07 28.9 0.1 1.6e-06 27.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO25657.1 - 1.5e-05 24.5 0.0 0.015 14.9 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_18 PF12847.2 KOO25657.1 - 0.0001 22.8 0.0 0.0013 19.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO25657.1 - 0.0037 17.2 0.1 0.025 14.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO25657.1 - 0.0037 17.6 0.0 0.013 15.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO25657.1 - 0.011 14.8 0.0 0.083 11.9 0.0 2.3 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.10 KOO25657.1 - 0.025 14.2 0.0 4.9 6.7 0.0 2.1 2 0 0 2 2 2 0 Hypothetical methyltransferase MTS PF05175.9 KOO25657.1 - 0.096 12.0 0.0 0.27 10.5 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain Toxin_18 PF08087.6 KOO25657.1 - 8 6.3 6.5 1.3e+02 2.4 1.8 3.1 1 1 2 3 3 3 0 Conotoxin O-superfamily HAD_2 PF13419.1 KOO25658.1 - 5.3e-07 30.0 3.5 7.6e-07 29.5 0.0 2.4 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Redoxin PF08534.5 KOO25659.1 - 7.2e-11 41.8 0.0 9.4e-11 41.4 0.0 1.2 1 0 0 1 1 1 1 Redoxin FeS PF04060.8 KOO25659.1 - 0.12 11.9 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Putative Fe-S cluster adh_short PF00106.20 KOO25661.1 - 8.3e-28 97.3 0.1 1.1e-27 97.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KOO25661.1 - 2.9e-11 43.6 0.1 3.8e-11 43.2 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KOO25661.1 - 4.4e-08 32.9 0.0 6.9e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 KOO25661.1 - 0.00011 22.2 0.4 0.00037 20.5 0.2 1.7 1 1 0 1 1 1 1 NADH(P)-binding ApbA PF02558.11 KOO25661.1 - 0.013 14.9 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Epimerase PF01370.16 KOO25661.1 - 0.028 13.8 0.2 0.087 12.2 0.0 1.9 1 1 1 2 2 2 0 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.14 KOO25661.1 - 0.039 13.0 0.2 0.19 10.7 0.0 2.2 2 1 1 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.13 KOO25661.1 - 0.051 13.2 0.3 0.081 12.5 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 KOO25661.1 - 0.093 11.6 0.2 0.2 10.6 0.1 1.5 2 0 0 2 2 2 0 Saccharopine dehydrogenase Methyltransf_16 PF10294.4 KOO25662.1 - 4.9e-24 84.7 0.0 7.4e-24 84.1 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_26 PF13659.1 KOO25662.1 - 0.00077 19.4 0.7 0.0019 18.2 0.4 1.8 1 1 1 2 2 2 1 Methyltransferase domain MTS PF05175.9 KOO25662.1 - 0.0029 16.9 0.0 0.0048 16.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.2 KOO25662.1 - 0.0053 17.3 0.0 0.011 16.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.10 KOO25662.1 - 0.022 14.1 0.1 0.034 13.5 0.1 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_23 PF13489.1 KOO25662.1 - 0.028 14.1 0.0 0.045 13.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Pep_M12B_propep PF01562.14 KOO25662.1 - 0.033 13.9 0.0 0.058 13.1 0.0 1.3 1 0 0 1 1 1 0 Reprolysin family propeptide PrmA PF06325.8 KOO25662.1 - 0.1 11.6 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) adh_short_C2 PF13561.1 KOO25663.1 - 7.7e-27 94.6 0.1 8.8e-27 94.4 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 KOO25663.1 - 1.3e-09 38.1 0.1 1.9e-09 37.6 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase DEAD PF00270.24 KOO25664.1 - 6.3e-10 38.8 0.0 1.8e-09 37.2 0.0 1.6 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO25664.1 - 5.4e-07 29.3 0.0 1e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Arm PF00514.18 KOO25665.1 - 4.7e-28 96.0 7.0 9.2e-09 34.8 0.2 4.4 4 0 0 4 4 4 4 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 KOO25665.1 - 0.00026 20.1 0.0 0.067 12.2 0.0 2.7 1 1 2 3 3 3 3 Armadillo-like DUF1840 PF08895.6 KOO25665.1 - 2.2 8.3 6.0 1.5 8.9 0.3 3.0 1 1 3 4 4 4 0 Domain of unknown function (DUF1840) Arm PF00514.18 KOO25667.1 - 1.1e-51 170.9 63.6 2.1e-05 24.1 0.1 18.3 19 0 0 19 19 19 13 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO25667.1 - 3.3e-22 78.5 53.6 0.00026 21.2 0.4 11.5 4 3 6 11 11 11 7 HEAT repeats HEAT PF02985.17 KOO25667.1 - 3.5e-13 48.4 17.1 0.15 12.2 0.1 9.9 9 0 0 9 9 8 4 HEAT repeat Adaptin_N PF01602.15 KOO25667.1 - 2.3e-09 36.1 6.1 5.5e-06 24.9 0.8 4.0 3 1 0 3 3 3 2 Adaptin N terminal region Arm_2 PF04826.8 KOO25667.1 - 7.4e-06 25.2 0.3 3.8 6.5 0.0 6.2 5 2 3 8 8 8 1 Armadillo-like HEAT_EZ PF13513.1 KOO25667.1 - 1.7e-05 25.1 51.1 0.012 16.0 0.0 11.9 11 1 0 12 12 12 4 HEAT-like repeat KAP PF05804.7 KOO25667.1 - 0.00043 18.3 0.1 0.64 7.8 0.0 2.4 2 0 0 2 2 2 2 Kinesin-associated protein (KAP) V-ATPase_H_C PF11698.3 KOO25667.1 - 0.00076 19.3 1.3 0.44 10.4 0.0 4.8 5 1 0 5 5 5 1 V-ATPase subunit H WAPL PF07814.8 KOO25667.1 - 0.0032 16.2 0.2 1.2 7.7 0.1 2.5 2 0 0 2 2 2 2 Wings apart-like protein regulation of heterochromatin Proteasom_PSMB PF10508.4 KOO25667.1 - 0.013 13.7 2.5 0.032 12.5 0.1 2.9 4 0 0 4 4 4 0 Proteasome non-ATPase 26S subunit V-ATPase_H_N PF03224.9 KOO25667.1 - 0.1 11.6 0.2 8.2 5.4 0.0 3.3 3 0 0 3 3 3 0 V-ATPase subunit H E3_UbLigase_R4 PF13764.1 KOO25667.1 - 0.22 9.3 0.6 1.2 6.9 0.1 2.2 2 1 0 2 2 2 0 E3 ubiquitin-protein ligase UBR4 DUF659 PF04937.10 KOO25668.1 - 9.4e-05 21.9 0.0 9.8e-05 21.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) SIS PF01380.17 KOO25669.1 - 1.8e-59 199.0 0.1 1.3e-33 115.3 0.0 3.2 3 0 0 3 3 3 2 SIS domain GATase_6 PF13522.1 KOO25669.1 - 1.2e-24 86.7 0.0 2.3e-24 85.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_2 PF00310.16 KOO25669.1 - 1.1e-17 63.7 0.4 8.6e-14 51.0 0.1 2.2 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_7 PF13537.1 KOO25669.1 - 9.3e-17 60.9 0.0 1.9e-16 59.9 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain SIS_2 PF13580.1 KOO25669.1 - 0.00013 21.7 0.0 0.00055 19.6 0.0 2.1 2 0 0 2 2 2 1 SIS domain GATase_4 PF13230.1 KOO25669.1 - 0.00025 19.8 0.0 0.00049 18.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II PDZ PF00595.19 KOO25670.1 - 2.9e-05 24.1 0.5 4.7e-05 23.4 0.3 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO25670.1 - 3e-05 23.8 0.1 6.4e-05 22.7 0.1 1.5 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.1 KOO25670.1 - 0.087 12.6 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Tricorn protease PDZ domain LRR_4 PF12799.2 KOO25671.1 - 4.1e-32 109.2 30.1 3.3e-07 29.7 0.1 7.3 3 3 4 8 8 8 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO25671.1 - 2e-26 91.5 23.1 1.7e-07 30.8 0.2 5.9 4 2 2 6 6 6 5 Leucine rich repeat LRR_1 PF00560.28 KOO25671.1 - 2.7e-21 72.2 24.0 0.12 12.5 0.0 10.9 11 0 0 11 11 11 7 Leucine Rich Repeat LRR_6 PF13516.1 KOO25671.1 - 2.2e-08 33.3 21.5 5.5 7.3 0.0 10.0 10 0 0 10 10 10 4 Leucine Rich repeat LRR_7 PF13504.1 KOO25671.1 - 4.4e-08 32.0 22.4 1.3 9.4 0.0 10.3 11 0 0 11 11 11 4 Leucine rich repeat DUF3338 PF11819.3 KOO25671.1 - 0.19 11.1 0.0 13 5.1 0.0 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF3338) MSP PF01716.13 KOO25672.1 - 9.7e-92 306.4 0.7 1.2e-91 306.1 0.5 1.1 1 0 0 1 1 1 1 Manganese-stabilising protein / photosystem II polypeptide HLH PF00010.21 KOO25673.1 - 9e-10 38.1 0.1 2e-09 36.9 0.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain ComC PF03047.9 KOO25673.1 - 0.084 12.3 0.6 0.16 11.4 0.4 1.4 1 0 0 1 1 1 0 COMC family DUF2075 PF09848.4 KOO25673.1 - 0.086 11.7 0.2 0.11 11.3 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) SEP PF08059.8 KOO25674.1 - 8.3e-08 32.4 0.0 1.5e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 SEP domain UBX PF00789.15 KOO25674.1 - 0.00039 20.4 0.0 0.00096 19.1 0.0 1.7 1 0 0 1 1 1 1 UBX domain Serglycin PF04360.7 KOO25674.1 - 0.0024 17.6 3.9 0.1 12.3 0.4 2.6 2 0 0 2 2 2 2 Serglycin DivIC PF04977.10 KOO25674.1 - 0.02 14.3 0.1 0.034 13.6 0.1 1.3 1 0 0 1 1 1 0 Septum formation initiator CASP_C PF08172.7 KOO25674.1 - 0.021 13.8 0.1 0.034 13.1 0.1 1.2 1 0 0 1 1 1 0 CASP C terminal TMF_TATA_bd PF12325.3 KOO25674.1 - 0.18 11.5 0.8 0.29 10.8 0.6 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding HALZ PF02183.13 KOO25674.1 - 0.46 10.2 1.9 0.38 10.5 0.3 1.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper EF-hand_5 PF13202.1 KOO25676.1 - 2.3e-14 51.9 7.4 0.0059 15.8 0.0 5.9 4 1 2 6 6 6 5 EF hand EF-hand_1 PF00036.27 KOO25676.1 - 1.7e-12 45.6 9.9 0.042 13.1 0.2 6.5 4 1 3 7 7 7 5 EF hand EF-hand_6 PF13405.1 KOO25676.1 - 5.8e-10 38.1 9.3 0.86 9.6 0.0 6.1 4 1 3 7 7 7 5 EF-hand domain EF-hand_7 PF13499.1 KOO25676.1 - 9.1e-07 28.9 11.5 0.012 15.7 0.3 4.8 1 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO25676.1 - 2.9e-06 26.7 6.2 1.4 8.6 0.0 5.6 3 1 2 5 5 5 2 EF-hand domain pair Dockerin_1 PF00404.13 KOO25676.1 - 0.005 16.4 13.8 1.7 8.5 0.0 4.7 4 0 0 4 4 4 2 Dockerin type I repeat FG-GAP PF01839.18 KOO25676.1 - 0.1 12.3 4.4 47 3.8 0.0 4.6 5 0 0 5 5 5 0 FG-GAP repeat zf-GRF PF06839.7 KOO25677.1 - 1.1e-11 44.4 2.2 2.1e-11 43.5 1.5 1.5 1 0 0 1 1 1 1 GRF zinc finger Zn_clus PF00172.13 KOO25678.1 - 1.7e-12 47.0 23.2 5.3e-07 29.4 7.2 2.5 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Telomere_Sde2 PF13019.1 KOO25679.1 - 2.5e-13 50.0 5.1 2.8e-13 49.8 3.6 1.2 1 0 0 1 1 1 1 Telomere stability and silencing Peptidase_M14 PF00246.19 KOO25680.1 - 1.5e-24 87.1 0.0 2.1e-24 86.6 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.9 KOO25680.1 - 0.00047 19.1 0.1 0.00088 18.2 0.1 1.4 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family Kin17_mid PF10357.4 KOO25681.1 - 1.2e-42 144.5 5.0 1.8e-42 143.9 3.5 1.3 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-met PF12874.2 KOO25681.1 - 0.0021 18.1 4.9 0.0054 16.8 3.4 1.8 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 KOO25681.1 - 0.022 14.9 4.6 0.052 13.6 3.2 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Ribosomal_S18 PF01084.15 KOO25681.1 - 0.047 13.5 0.3 0.15 11.9 0.2 1.8 1 0 0 1 1 1 0 Ribosomal protein S18 SopA PF13981.1 KOO25681.1 - 0.053 13.5 1.2 0.09 12.7 0.9 1.3 1 0 0 1 1 1 0 SopA-like central domain DUF399 PF04187.8 KOO25681.1 - 0.27 10.7 3.3 0.59 9.5 2.3 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF399 zf-C2H2_2 PF12756.2 KOO25681.1 - 0.3 11.2 7.3 0.29 11.2 2.2 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) DUF4164 PF13747.1 KOO25681.1 - 0.62 10.2 8.2 1.5 9.0 5.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Phage_min_cap2 PF06152.6 KOO25681.1 - 0.94 8.3 6.4 1.2 8.0 0.0 2.1 2 0 0 2 2 2 0 Phage minor capsid protein 2 UIM PF02809.15 KOO25682.1 - 5.7e-05 22.3 4.4 0.082 12.5 0.1 3.1 2 0 0 2 2 2 2 Ubiquitin interaction motif Peptidase_M10 PF00413.19 KOO25682.1 - 0.017 14.8 0.0 6.5 6.4 0.0 2.3 2 0 0 2 2 2 0 Matrixin PARP PF00644.15 KOO25684.1 - 4.7e-14 52.2 0.0 9.8e-14 51.2 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain SseC PF04888.7 KOO25684.1 - 2.2 7.5 10.0 4 6.6 6.9 1.4 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family UPF0444 PF15475.1 KOO25684.1 - 7.6 6.6 11.7 21 5.2 8.1 1.7 1 0 0 1 1 1 0 Transmembrane protein C12orf23, UPF0444 MFS_1 PF07690.11 KOO25685.1 - 2.9e-18 65.7 41.5 2.2e-09 36.4 5.6 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 KOO25685.1 - 5.3e-05 21.9 3.1 0.0016 17.1 0.0 2.5 2 1 0 2 2 2 2 Sugar (and other) transporter LacY_symp PF01306.14 KOO25685.1 - 2 6.8 11.1 2.1 6.8 0.2 2.5 2 1 0 2 2 2 0 LacY proton/sugar symporter Fst_toxin PF13955.1 KOO25685.1 - 2.7 7.7 11.5 0.2 11.3 1.9 3.3 3 0 0 3 3 3 0 Toxin Fst, type I toxin-antitoxin system Glyco_transf_90 PF05686.7 KOO25686.1 - 1.5e-41 142.4 0.0 2.5e-41 141.6 0.0 1.3 1 1 0 1 1 1 1 Glycosyl transferase family 90 Complex1_LYR PF05347.10 KOO25686.1 - 1.7e-05 24.4 1.0 0.00031 20.4 0.1 3.2 3 1 0 3 3 3 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 KOO25686.1 - 1.8e-05 24.8 0.1 5.5e-05 23.2 0.0 1.9 2 0 0 2 2 2 1 Complex1_LYR-like Glyco_trans_1_2 PF13524.1 KOO25686.1 - 0.00042 20.5 0.0 0.00096 19.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Pkinase PF00069.20 KOO25687.1 - 7.6e-21 74.4 0.0 1.1e-20 73.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25687.1 - 1.5e-08 34.0 0.0 2e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO25687.1 - 0.011 15.4 4.2 0.015 15.0 0.3 2.6 3 0 0 3 3 3 0 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO25687.1 - 0.055 12.4 0.0 0.12 11.2 0.0 1.4 1 1 0 1 1 1 0 Kinase-like EF-hand_1 PF00036.27 KOO25689.1 - 3e-33 110.5 22.1 3.3e-06 25.9 0.2 6.4 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.1 KOO25689.1 - 3.1e-32 110.5 15.8 5.3e-12 45.6 1.8 3.6 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO25689.1 - 2.3e-29 98.5 20.9 7e-05 22.3 0.2 6.5 6 0 0 6 6 6 5 EF-hand domain EF-hand_8 PF13833.1 KOO25689.1 - 3e-26 90.7 15.1 3.4e-11 42.5 0.1 5.3 3 1 2 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.1 KOO25689.1 - 5.4e-19 66.6 26.4 2.5e-05 23.4 0.3 5.9 6 0 0 6 6 6 5 EF hand EF-hand_10 PF14788.1 KOO25689.1 - 5.6e-05 22.7 9.6 4.2 7.1 0.0 6.1 5 1 1 6 6 6 1 EF hand EF-hand_9 PF14658.1 KOO25689.1 - 0.00014 21.7 0.1 2.2 8.2 0.0 4.0 3 1 2 5 5 5 1 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO25689.1 - 0.00035 20.5 3.4 1.3 9.0 0.0 3.8 2 2 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region DNA_circ_N PF07157.7 KOO25689.1 - 0.032 14.3 0.0 28 4.9 0.0 3.2 3 0 0 3 3 3 0 DNA circularisation protein N-terminus DUF1880 PF08976.6 KOO25689.1 - 0.045 13.8 0.3 0.19 11.8 0.0 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1880) DUF1632 PF07857.7 KOO25691.1 - 0.012 14.8 15.5 0.22 10.7 0.6 4.1 2 1 2 4 4 4 0 CEO family (DUF1632) Synaptobrevin PF00957.16 KOO25692.1 - 2.1e-20 72.1 0.0 3.1e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.1 KOO25692.1 - 0.0066 15.9 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Transcrip_reg PF01709.15 KOO25693.1 - 4e-40 137.4 0.2 4.6e-40 137.2 0.2 1.0 1 0 0 1 1 1 1 Transcriptional regulator DUF3683 PF12447.3 KOO25693.1 - 0.097 12.5 0.1 0.52 10.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3683) DUF3619 PF12279.3 KOO25693.1 - 0.13 12.3 1.0 0.39 10.8 0.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3619) Baculo_PP31 PF05311.6 KOO25695.1 - 0.033 13.4 3.7 0.026 13.8 1.6 1.6 1 1 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) ADIP PF11559.3 KOO25695.1 - 0.1 12.5 26.6 0.75 9.6 3.0 2.3 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding RE_HindIII PF09518.5 KOO25695.1 - 0.13 11.1 11.8 0.18 10.6 8.2 1.2 1 0 0 1 1 1 0 HindIII restriction endonuclease V_ATPase_I PF01496.14 KOO25695.1 - 0.15 9.8 13.0 0.19 9.5 9.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SASP PF00269.15 KOO25695.1 - 0.16 11.8 5.6 0.81 9.5 3.9 2.3 1 1 0 1 1 1 0 Small, acid-soluble spore proteins, alpha/beta type AATF-Che1 PF13339.1 KOO25695.1 - 0.19 11.8 13.7 0.15 12.1 8.5 1.5 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor Spc7 PF08317.6 KOO25695.1 - 0.26 9.9 25.0 0.87 8.1 17.5 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF1515 PF07439.6 KOO25695.1 - 0.3 10.9 5.4 0.53 10.1 3.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1515) Perilipin PF03036.11 KOO25695.1 - 0.33 9.7 8.4 0.39 9.5 5.8 1.1 1 0 0 1 1 1 0 Perilipin family FliJ PF02050.11 KOO25695.1 - 0.4 10.7 29.9 0.32 11.0 15.9 2.8 1 1 2 3 3 3 0 Flagellar FliJ protein DUF1664 PF07889.7 KOO25695.1 - 0.78 9.5 16.5 2.1 8.1 5.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Atg14 PF10186.4 KOO25695.1 - 1.1 8.1 21.9 3.9 6.3 15.1 1.9 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 CorA PF01544.13 KOO25695.1 - 1.2 8.0 14.1 0.55 9.2 7.9 1.6 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Baculo_PEP_C PF04513.7 KOO25695.1 - 1.4 8.7 6.1 6 6.6 1.7 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2564 PF10819.3 KOO25695.1 - 2.8 8.1 15.9 0.59 10.2 4.3 3.0 2 2 1 3 3 3 0 Protein of unknown function (DUF2564) CDC37_N PF03234.9 KOO25695.1 - 4.9 7.4 20.2 3.2 8.0 11.9 1.9 1 1 1 2 2 2 0 Cdc37 N terminal kinase binding Striatin PF08232.7 KOO25695.1 - 7.4 6.8 19.9 2.3 8.5 7.5 2.2 1 1 1 2 2 2 0 Striatin family DASH_Spc34 PF08657.5 KOO25695.1 - 8.9 5.8 22.4 0.12 12.0 7.6 2.7 1 1 2 3 3 3 0 DASH complex subunit Spc34 LUC7 PF03194.10 KOO25695.1 - 9.4 5.6 19.2 1.1 8.7 10.0 1.7 1 1 1 2 2 2 0 LUC7 N_terminus zf-RING_2 PF13639.1 KOO25698.1 - 0.0046 16.7 4.6 0.0079 16.0 3.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 KOO25698.1 - 0.35 10.5 12.1 3.1 7.5 8.4 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO25698.1 - 0.6 10.1 10.0 0.64 10.0 4.9 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO25698.1 - 4.7 6.9 12.0 1.2 8.8 5.5 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FGE-sulfatase PF03781.11 KOO25699.1 - 1.2e-24 87.1 4.1 2.8e-24 85.8 2.8 1.7 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 Methyltransf_18 PF12847.2 KOO25699.1 - 4.7e-13 49.6 0.0 8.9e-13 48.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO25699.1 - 6.1e-11 42.1 0.0 1.5e-05 24.5 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.7 KOO25699.1 - 1.4e-10 41.5 0.0 7.4e-10 39.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO25699.1 - 3.3e-09 36.6 0.0 6.8e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO25699.1 - 1e-08 35.4 0.0 2.8e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO25699.1 - 6e-08 33.0 0.0 3.3e-07 30.7 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain DinB_2 PF12867.2 KOO25699.1 - 7.7e-08 32.7 1.0 1.6e-07 31.6 0.7 1.6 1 0 0 1 1 1 1 DinB superfamily Methyltransf_4 PF02390.12 KOO25699.1 - 0.0052 15.8 0.0 0.01 14.8 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Ubie_methyltran PF01209.13 KOO25699.1 - 0.0095 15.0 0.0 4.3 6.3 0.0 2.3 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family TPMT PF05724.6 KOO25699.1 - 0.042 13.2 0.0 0.073 12.4 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_15 PF09445.5 KOO25699.1 - 0.043 13.3 0.0 0.075 12.5 0.0 1.4 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase NodS PF05401.6 KOO25699.1 - 0.046 13.1 0.0 0.078 12.3 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_32 PF13679.1 KOO25699.1 - 0.16 11.6 0.0 0.28 10.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain TPR_12 PF13424.1 KOO25700.1 - 1.4e-31 108.2 30.5 5.4e-12 45.4 2.1 6.1 5 1 2 7 7 7 5 Tetratricopeptide repeat TPR_10 PF13374.1 KOO25700.1 - 1.4e-21 75.6 35.7 0.003 17.4 0.1 9.1 8 1 0 8 8 8 6 Tetratricopeptide repeat EF-hand_1 PF00036.27 KOO25700.1 - 8.6e-16 55.9 1.4 4.3e-07 28.7 0.6 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO25700.1 - 1.9e-13 49.0 1.6 8.1e-06 24.9 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO25700.1 - 4.8e-13 49.0 0.1 1.3e-12 47.6 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO25700.1 - 4.5e-12 44.7 0.1 0.0002 20.9 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO25700.1 - 1.2e-09 37.5 0.7 0.00047 19.7 0.1 3.4 3 0 0 3 3 3 2 EF-hand domain pair TPR_2 PF07719.12 KOO25700.1 - 8.3e-06 25.3 22.2 1.8 8.6 0.0 7.8 8 0 0 8 8 8 2 Tetratricopeptide repeat EF-hand_9 PF14658.1 KOO25700.1 - 0.00012 21.9 0.0 0.00027 20.8 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain TPR_14 PF13428.1 KOO25700.1 - 0.00059 20.2 28.5 9.7 7.1 0.2 7.5 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.1 KOO25700.1 - 0.0011 18.5 21.8 0.03 13.9 0.7 5.9 4 2 2 6 6 6 3 TPR repeat TPR_7 PF13176.1 KOO25700.1 - 0.0041 16.8 24.2 0.28 11.0 0.7 7.0 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO25700.1 - 0.0056 17.3 32.3 0.091 13.4 3.0 5.8 4 1 1 5 5 5 2 Tetratricopeptide repeat EF-hand_10 PF14788.1 KOO25700.1 - 0.014 15.0 0.6 2 8.1 0.0 3.0 3 0 0 3 3 2 0 EF hand TPR_1 PF00515.23 KOO25700.1 - 0.044 13.4 25.6 0.12 12.0 0.0 7.1 8 0 0 8 8 8 0 Tetratricopeptide repeat SPARC_Ca_bdg PF10591.4 KOO25700.1 - 0.045 13.7 0.0 0.14 12.1 0.0 1.9 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region DUF917 PF06032.7 KOO25700.1 - 0.046 12.2 1.5 0.067 11.7 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF917) EF-hand_4 PF12763.2 KOO25700.1 - 0.15 11.7 0.6 0.66 9.7 0.2 2.0 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand TPR_19 PF14559.1 KOO25700.1 - 5.2 7.4 27.2 3.5 8.0 2.0 6.1 5 1 1 6 6 6 0 Tetratricopeptide repeat Peripla_BP_6 PF13458.1 KOO25701.1 - 0.032 13.5 0.8 0.052 12.8 0.6 1.3 1 0 0 1 1 1 0 Periplasmic binding protein Chromate_transp PF02417.10 KOO25702.1 - 1.1e-52 178.0 32.2 5.6e-32 110.6 8.7 2.3 2 0 0 2 2 2 2 Chromate transporter DUF3661 PF12400.3 KOO25703.1 - 5.9e-30 104.0 2.7 7.8e-30 103.6 1.9 1.2 1 0 0 1 1 1 1 Vaculolar membrane protein UPF0220 PF05255.6 KOO25703.1 - 0.014 14.6 0.8 0.16 11.1 0.0 2.2 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0220) DUF1778 PF08681.6 KOO25703.1 - 0.15 11.8 0.1 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1778) 7tm_7 PF08395.7 KOO25703.1 - 0.97 8.3 5.3 0.088 11.8 0.7 1.4 2 0 0 2 2 2 0 7tm Chemosensory receptor SecE PF00584.15 KOO25703.1 - 5.8 6.5 6.5 0.93 9.1 0.3 2.5 2 0 0 2 2 2 0 SecE/Sec61-gamma subunits of protein translocation complex PCRF PF03462.13 KOO25704.1 - 3.1e-37 126.8 0.7 1.1e-36 124.9 0.3 2.2 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.15 KOO25704.1 - 4.5e-37 126.3 1.0 1.2e-36 124.9 0.7 1.8 1 0 0 1 1 1 1 RF-1 domain DUF1083 PF06452.6 KOO25704.1 - 0.0027 17.5 0.0 0.0053 16.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1083) Acyl-CoA_dh_1 PF00441.19 KOO25705.1 - 9.2e-25 87.5 0.7 1.5e-24 86.7 0.5 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 KOO25705.1 - 1.3e-18 66.2 0.4 3.2e-18 64.9 0.1 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.11 KOO25705.1 - 3.6e-09 37.1 0.1 8e-06 26.4 0.0 2.8 1 1 1 2 2 2 2 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.6 KOO25705.1 - 8e-09 35.8 0.2 1.5e-08 34.9 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain TPR_MLP1_2 PF07926.7 KOO25706.1 - 0.00071 19.3 11.3 0.00071 19.3 7.8 3.5 1 1 0 2 2 2 1 TPR/MLP1/MLP2-like protein BLOC1_2 PF10046.4 KOO25706.1 - 3.9 7.6 13.7 1.3 9.2 0.5 3.4 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Transket_pyr PF02779.19 KOO25707.1 - 6.7e-12 45.2 0.0 1.1e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 KOO25707.1 - 0.14 10.8 0.0 0.21 10.2 0.0 1.3 1 0 0 1 1 1 0 Dehydrogenase E1 component NTR2 PF15458.1 KOO25708.1 - 5.4e-05 22.5 2.8 0.00011 21.5 1.9 1.5 1 0 0 1 1 1 1 Nineteen complex-related protein 2 Brix PF04427.13 KOO25709.1 - 1.5e-41 142.1 0.0 2.2e-41 141.6 0.0 1.2 1 0 0 1 1 1 1 Brix domain CoA_binding_2 PF13380.1 KOO25709.1 - 0.14 12.3 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 CoA binding domain Pkinase PF00069.20 KOO25710.1 - 8.9e-63 211.8 0.0 3e-62 210.1 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25710.1 - 3.5e-29 101.6 0.0 1.4e-21 76.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.19 KOO25710.1 - 4e-21 75.1 0.0 4e-20 71.8 0.0 2.3 2 0 0 2 2 2 1 Response regulator receiver domain Kinase-like PF14531.1 KOO25710.1 - 0.0052 15.7 0.0 0.11 11.3 0.0 2.1 2 0 0 2 2 2 1 Kinase-like DUF1194 PF06707.6 KOO25710.1 - 0.089 11.7 0.1 0.21 10.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1194) EF-hand_7 PF13499.1 KOO25711.1 - 6.7e-22 77.3 0.0 1.4e-13 50.7 0.0 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO25711.1 - 1.2e-21 74.3 0.2 3.1e-05 22.9 0.0 4.7 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.1 KOO25711.1 - 8e-20 68.9 0.1 9.3e-05 22.0 0.0 4.9 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.1 KOO25711.1 - 1.9e-11 42.7 2.1 0.009 15.3 0.0 4.6 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.1 KOO25711.1 - 2e-10 40.1 4.9 0.0043 16.6 0.0 4.5 3 2 2 5 5 5 4 EF-hand domain pair EF-hand_9 PF14658.1 KOO25711.1 - 0.009 15.9 0.0 3.6 7.5 0.0 2.8 2 1 1 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO25711.1 - 0.077 13.0 0.0 7.7 6.5 0.0 2.7 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region MMR_HSR1 PF01926.18 KOO25712.1 - 4.9e-15 55.5 0.0 7.9e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase NOG1 PF06858.9 KOO25712.1 - 2.5e-11 43.2 0.0 4.3e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) FeoB_N PF02421.13 KOO25712.1 - 3.1e-08 33.0 0.0 5.3e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Miro PF08477.8 KOO25712.1 - 0.0075 16.7 0.0 0.015 15.7 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein DUF258 PF03193.11 KOO25712.1 - 0.0099 15.0 0.1 0.02 14.0 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function, DUF258 HHH_5 PF14520.1 KOO25712.1 - 0.054 13.6 0.0 0.15 12.2 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain Peptidase_S9 PF00326.16 KOO25713.1 - 6.7e-38 130.0 0.0 7.3e-37 126.6 0.0 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 KOO25713.1 - 4.9e-08 32.8 0.3 1.7e-07 31.0 0.2 2.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 KOO25713.1 - 0.0062 16.1 0.1 0.015 14.8 0.1 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold BAAT_C PF08840.6 KOO25713.1 - 0.084 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.13 KOO25713.1 - 0.097 11.9 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family Response_reg PF00072.19 KOO25714.1 - 4.6e-19 68.4 0.1 3e-09 36.8 0.0 2.5 2 0 0 2 2 2 2 Response regulator receiver domain HATPase_c PF02518.21 KOO25714.1 - 1.9e-12 46.8 0.1 5e-12 45.5 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS PF00989.19 KOO25715.1 - 2.2e-15 56.4 0.0 1.2e-09 37.9 0.0 2.1 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.5 KOO25715.1 - 5.6e-14 52.1 0.0 3.1e-08 33.6 0.0 2.1 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.1 KOO25715.1 - 1.9e-11 44.2 0.0 4e-08 33.5 0.0 2.1 2 0 0 2 2 2 2 PAS domain PAS_8 PF13188.1 KOO25715.1 - 4.9e-06 26.1 0.0 0.022 14.6 0.0 2.4 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.6 KOO25715.1 - 0.085 12.9 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 PAS fold LRR_8 PF13855.1 KOO25716.1 - 7.2e-21 73.7 9.3 3.8e-09 36.1 1.1 4.9 4 1 1 5 5 5 5 Leucine rich repeat LRR_1 PF00560.28 KOO25716.1 - 3.3e-20 69.0 10.6 0.039 13.9 0.0 9.0 10 0 0 10 10 10 7 Leucine Rich Repeat LRR_4 PF12799.2 KOO25716.1 - 6.1e-19 67.2 16.9 4.3e-05 23.0 0.7 6.6 3 3 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO25716.1 - 3e-09 35.9 12.4 1.6 9.0 0.1 7.7 7 0 0 7 7 7 4 Leucine Rich repeat LRR_7 PF13504.1 KOO25716.1 - 3.1e-07 29.4 6.6 12 6.6 0.0 7.2 7 0 0 7 7 7 2 Leucine rich repeat DUF2759 PF10958.3 KOO25717.1 - 1.8 8.1 10.1 2.4 7.7 0.9 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2759) Asp PF00026.18 KOO25718.1 - 9.5e-24 84.2 0.0 1.3e-18 67.3 0.0 2.1 2 0 0 2 2 2 2 Eukaryotic aspartyl protease IRK PF01007.15 KOO25720.1 - 4.5e-26 91.4 6.0 9.3e-26 90.4 0.3 2.0 1 1 0 2 2 2 2 Inward rectifier potassium channel Ion_trans_2 PF07885.11 KOO25720.1 - 0.013 15.1 7.0 0.025 14.2 4.9 1.5 1 0 0 1 1 1 0 Ion channel Glucan_synthase PF02364.10 KOO25721.1 - 0.077 10.8 0.0 0.12 10.2 0.0 1.1 1 0 0 1 1 1 0 1,3-beta-glucan synthase component Dynein_heavy PF03028.10 KOO25722.1 - 1.5e-207 691.0 0.0 2.5e-207 690.2 0.0 1.3 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor AAA_8 PF12780.2 KOO25722.1 - 4.4e-61 206.2 0.0 9.5e-61 205.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 KOO25722.1 - 4.9e-60 202.1 0.0 8.4e-60 201.4 0.0 1.4 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_7 PF12775.2 KOO25722.1 - 1.3e-44 152.3 0.4 3.1e-44 151.0 0.0 1.8 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 MT PF12777.2 KOO25722.1 - 2.9e-44 151.2 11.4 4.4e-44 150.6 7.9 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.9 KOO25722.1 - 7.9e-08 32.1 0.2 0.00033 20.3 0.0 3.4 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA PF00004.24 KOO25722.1 - 0.02 15.0 0.1 0.095 12.8 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Flagellin_C PF00700.16 KOO25722.1 - 0.024 14.7 1.7 0.073 13.2 1.2 1.9 1 0 0 1 1 1 0 Bacterial flagellin C-terminal helical region AAA_16 PF13191.1 KOO25722.1 - 0.055 13.4 2.6 22 4.9 0.0 3.9 3 1 0 3 3 3 0 AAA ATPase domain KaiC PF06745.8 KOO25722.1 - 0.1 11.6 0.0 0.3 10.1 0.0 1.7 1 0 0 1 1 1 0 KaiC Myosin_tail_1 PF01576.14 KOO25722.1 - 4.9 4.7 13.3 2.2 5.9 2.7 2.1 2 0 0 2 2 2 0 Myosin tail Actin PF00022.14 KOO25724.1 - 3.1e-114 381.4 0.0 4.2e-114 381.0 0.0 1.2 1 0 0 1 1 1 1 Actin zf-H2C2_2 PF13465.1 KOO25725.1 - 2.1e-26 90.8 45.9 1.4e-06 28.2 0.9 7.3 7 1 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.21 KOO25725.1 - 1.4e-25 88.0 48.0 6.5e-06 26.1 3.2 6.6 6 1 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOO25725.1 - 8.8e-16 57.0 37.2 0.0025 18.0 0.7 6.5 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_6 PF13912.1 KOO25725.1 - 3.8e-07 29.7 23.2 0.028 14.3 0.1 6.0 6 0 0 6 6 6 3 C2H2-type zinc finger CHORD PF04968.7 KOO25725.1 - 0.04 14.1 28.3 2.2 8.6 0.4 5.3 1 1 4 5 5 5 0 CHORD zf-C2H2_jaz PF12171.3 KOO25725.1 - 0.13 12.3 31.3 2.8 8.1 0.4 6.4 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding Fer2 PF00111.22 KOO25725.1 - 0.39 10.5 0.1 0.39 10.5 0.0 5.3 6 0 0 6 6 6 0 2Fe-2S iron-sulfur cluster binding domain FANCL_C PF11793.3 KOO25725.1 - 0.99 9.4 29.0 2.8 7.9 0.1 7.0 2 2 5 7 7 7 0 FANCL C-terminal domain TP1 PF02079.11 KOO25725.1 - 2.1 8.2 10.8 9.7 6.0 0.2 4.3 3 1 0 4 4 4 0 Nuclear transition protein 1 zf-C2H2_2 PF12756.2 KOO25725.1 - 2.7 8.1 15.2 54 3.9 6.7 3.9 3 2 1 4 4 4 0 C2H2 type zinc-finger (2 copies) IQ PF00612.22 KOO25726.1 - 0.012 15.1 3.9 0.016 14.8 0.1 2.7 2 0 0 2 2 2 0 IQ calmodulin-binding motif TSC22 PF01166.13 KOO25726.1 - 0.031 14.2 0.6 0.031 14.2 0.4 3.3 3 0 0 3 3 3 0 TSC-22/dip/bun family SYF2 PF08231.7 KOO25728.1 - 3.1e-32 111.8 3.1 3.1e-32 111.8 2.1 1.8 1 1 0 2 2 2 1 SYF2 splicing factor Trs65 PF12735.2 KOO25729.1 - 0.12 11.7 0.0 0.12 11.6 0.0 1.0 1 0 0 1 1 1 0 TRAPP trafficking subunit Trs65 U-box PF04564.10 KOO25730.1 - 2.9e-15 55.9 0.0 4.3e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO25730.1 - 6.2e-05 22.4 0.0 0.00012 21.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 KOO25730.1 - 0.055 13.1 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 RING-type zinc-finger SOBP PF15279.1 KOO25730.1 - 0.54 10.5 3.9 0.68 10.2 2.7 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein GH97_C PF14509.1 KOO25730.1 - 0.57 10.3 4.8 6.2 6.9 0.1 2.8 3 1 0 3 3 3 0 Glycosyl-hydrolase 97 C-terminal, oligomerisation PLRV_ORF5 PF01690.12 KOO25730.1 - 0.6 9.1 8.4 0.7 8.9 5.8 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein SAPS PF04499.10 KOO25730.1 - 0.82 8.2 5.4 1.1 7.8 3.8 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RR_TM4-6 PF06459.7 KOO25730.1 - 0.83 9.4 20.2 1.2 8.9 14.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Asp-B-Hydro_N PF05279.6 KOO25730.1 - 1.3 8.8 19.2 1.6 8.5 13.3 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF1675 PF07897.6 KOO25730.1 - 2.1 8.1 10.3 3 7.6 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) RNA_pol_Rpb1_1 PF04997.7 KOO25730.1 - 9.3 5.3 7.5 12 5.0 5.2 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 1 U-box PF04564.10 KOO25731.1 - 1.1e-15 57.2 0.0 1.7e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 U-box domain Sel1 PF08238.7 KOO25731.1 - 5.5e-14 52.2 4.5 1e-07 32.3 0.3 3.0 2 0 0 2 2 2 2 Sel1 repeat zf-Nse PF11789.3 KOO25731.1 - 7.3e-05 22.2 0.0 0.00014 21.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Asp-B-Hydro_N PF05279.6 KOO25731.1 - 0.052 13.3 18.1 0.071 12.9 12.6 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region zf-RING_UBOX PF13445.1 KOO25731.1 - 0.065 12.9 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 RING-type zinc-finger PLRV_ORF5 PF01690.12 KOO25731.1 - 0.17 11.0 6.4 0.19 10.8 4.5 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein SOBP PF15279.1 KOO25731.1 - 0.18 12.1 2.9 0.2 11.9 2.0 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF1675 PF07897.6 KOO25731.1 - 0.52 10.1 7.8 0.67 9.7 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) SAPS PF04499.10 KOO25731.1 - 0.78 8.3 5.9 0.9 8.0 4.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PMSI1 PF15322.1 KOO25731.1 - 4 6.4 13.2 5.6 5.9 9.1 1.2 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative Myosin_head PF00063.16 KOO25732.1 - 2.1e-191 637.5 1.4 4.2e-191 636.5 0.0 2.0 2 0 0 2 2 2 1 Myosin head (motor domain) Arm PF00514.18 KOO25732.1 - 1.1e-24 85.3 44.1 0.016 15.0 0.6 13.6 13 0 0 13 13 13 8 Armadillo/beta-catenin-like repeat Myb_DNA-binding PF00249.26 KOO25732.1 - 8.8e-15 54.5 0.2 3.3e-14 52.6 0.1 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO25732.1 - 8.5e-11 41.7 0.2 2.3e-10 40.4 0.1 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF383 PF04063.9 KOO25732.1 - 0.00023 20.7 0.7 0.0022 17.5 0.3 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF383) AAA_22 PF13401.1 KOO25732.1 - 0.0093 16.1 0.0 0.078 13.1 0.0 2.6 3 0 0 3 3 3 1 AAA domain Borrelia_P83 PF05262.6 KOO25732.1 - 4.9 5.3 37.6 13 3.9 26.1 1.6 1 0 0 1 1 1 0 Borrelia P83/100 protein Filamin PF00630.14 KOO25734.1 - 5.7e-32 110.3 0.2 2.4e-15 56.9 0.0 4.8 5 0 0 5 5 5 4 Filamin/ABP280 repeat Neurexophilin PF06312.7 KOO25734.1 - 0.013 14.7 2.5 0.013 14.7 0.2 2.1 2 0 0 2 2 2 0 Neurexophilin Metallophos PF00149.23 KOO25735.1 - 3.2e-26 91.9 0.1 3.9e-26 91.7 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KOO25735.1 - 2.8e-07 30.5 0.0 1e-06 28.7 0.0 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Mre11_DNA_bind PF04152.9 KOO25735.1 - 0.00012 21.9 0.0 0.00018 21.4 0.0 1.3 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Form_Nir_trans PF01226.12 KOO25737.1 - 3.7e-53 179.9 18.6 4.6e-53 179.6 12.9 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter Lipase_3 PF01764.20 KOO25738.1 - 4.7e-41 139.7 0.0 6.4e-41 139.2 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Cutinase PF01083.17 KOO25738.1 - 8.2e-05 22.4 0.1 0.00014 21.6 0.1 1.3 1 0 0 1 1 1 1 Cutinase Abhydrolase_6 PF12697.2 KOO25738.1 - 0.0041 17.0 0.0 0.0053 16.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO25738.1 - 0.0056 16.4 0.0 0.0061 16.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.3 KOO25738.1 - 0.01 15.2 0.4 0.064 12.6 0.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_8 PF06259.7 KOO25738.1 - 0.065 12.7 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase AAA PF00004.24 KOO25739.1 - 3.7e-39 133.9 0.0 1.6e-37 128.6 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO25739.1 - 4.9e-07 29.9 6.6 1.7e-05 24.8 0.1 3.8 3 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 KOO25739.1 - 1.1e-06 28.7 0.1 0.0008 19.5 0.0 3.4 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.9 KOO25739.1 - 1.4e-06 28.3 0.0 2.6e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.1 KOO25739.1 - 1.9e-05 25.0 0.0 2.9e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 KOO25739.1 - 4e-05 23.3 0.0 0.00014 21.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 KOO25739.1 - 7.4e-05 23.5 0.0 0.00015 22.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 KOO25739.1 - 8.6e-05 22.2 0.0 0.02 14.5 0.0 3.2 4 0 0 4 4 4 1 NACHT domain AAA_33 PF13671.1 KOO25739.1 - 0.00019 21.3 0.1 0.00055 19.8 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_28 PF13521.1 KOO25739.1 - 0.00037 20.5 0.0 0.00069 19.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOO25739.1 - 0.0015 17.6 0.0 0.0028 16.7 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin Rad17 PF03215.10 KOO25739.1 - 0.0037 16.0 0.0 0.0051 15.5 0.0 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein IstB_IS21 PF01695.12 KOO25739.1 - 0.0052 16.2 0.0 0.19 11.1 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein Mg_chelatase PF01078.16 KOO25739.1 - 0.006 15.7 0.0 0.014 14.5 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 KOO25739.1 - 0.0088 16.2 0.0 0.015 15.4 0.0 1.3 1 0 0 1 1 1 1 RNA helicase RuvB_N PF05496.7 KOO25739.1 - 0.011 14.8 0.0 0.022 13.7 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus TIP49 PF06068.8 KOO25739.1 - 0.013 14.2 0.0 0.022 13.5 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus UPF0079 PF02367.12 KOO25739.1 - 0.019 14.5 0.0 0.033 13.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_3 PF07726.6 KOO25739.1 - 0.032 13.8 0.0 0.06 12.9 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 KOO25739.1 - 0.052 13.4 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 KOO25739.1 - 0.059 12.7 2.0 1.9 7.8 0.0 3.2 2 1 1 3 3 3 0 AAA domain KaiC PF06745.8 KOO25739.1 - 0.06 12.4 0.0 0.096 11.7 0.0 1.2 1 0 0 1 1 1 0 KaiC AAA_31 PF13614.1 KOO25739.1 - 0.12 12.3 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.5 KOO25739.1 - 0.14 11.3 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DUF3661 PF12400.3 KOO25740.1 - 1.6e-21 76.7 1.5 2.2e-21 76.3 1.0 1.2 1 0 0 1 1 1 1 Vaculolar membrane protein CcoS PF03597.10 KOO25740.1 - 0.018 14.4 3.4 0.052 13.0 2.4 1.8 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type FixQ PF05545.6 KOO25740.1 - 3.6 7.3 10.8 0.32 10.6 3.6 2.2 3 0 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ CENP-F_leu_zip PF10473.4 KOO25741.1 - 2.1e-05 24.3 10.2 2.1e-05 24.3 7.0 2.7 2 1 1 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF812 PF05667.6 KOO25741.1 - 0.0023 16.5 15.4 0.003 16.1 10.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Noelin-1 PF12308.3 KOO25741.1 - 0.7 9.7 5.2 1 9.1 0.3 2.7 1 1 1 2 2 2 0 Neurogenesis glycoprotein End3 PF12761.2 KOO25741.1 - 1.4 8.5 12.0 0.32 10.5 5.3 1.9 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 DUF972 PF06156.8 KOO25741.1 - 2.5 8.4 15.8 1.1 9.6 2.8 3.2 1 1 3 4 4 4 0 Protein of unknown function (DUF972) TMCO5 PF14992.1 KOO25741.1 - 2.8 7.0 14.7 6 5.9 10.1 1.5 1 1 0 1 1 1 0 TMCO5 family COG2 PF06148.6 KOO25741.1 - 3.8 7.3 13.1 0.091 12.6 1.9 2.4 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 FlxA PF14282.1 KOO25741.1 - 4.2 7.3 12.2 0.94 9.4 4.0 2.8 2 2 0 2 2 2 0 FlxA-like protein DUF724 PF05266.9 KOO25741.1 - 5.5 6.5 24.2 0.22 11.1 6.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) cobW PF02492.14 KOO25742.1 - 3.1e-40 137.5 0.0 3.9e-40 137.1 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.9 KOO25742.1 - 0.0014 18.3 0.0 0.003 17.2 0.0 1.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.1 KOO25742.1 - 0.0043 16.7 0.5 0.016 14.9 0.1 2.3 2 0 0 2 2 2 1 Part of AAA domain ArgK PF03308.11 KOO25742.1 - 0.0045 15.7 0.7 0.012 14.3 0.5 1.8 1 1 0 1 1 1 1 ArgK protein HTH_42 PF06224.7 KOO25742.1 - 0.0046 16.3 0.1 0.0071 15.7 0.0 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain T2SE PF00437.15 KOO25742.1 - 0.013 14.3 0.1 0.024 13.5 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.1 KOO25742.1 - 0.014 15.5 0.0 0.028 14.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 KOO25742.1 - 0.031 14.2 0.1 0.07 13.1 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.1 KOO25742.1 - 0.045 13.6 0.0 0.075 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain CbiA PF01656.18 KOO25742.1 - 0.046 13.1 0.0 0.35 10.2 0.0 2.2 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_10 PF12846.2 KOO25742.1 - 0.061 12.7 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA-like domain Viral_helicase1 PF01443.13 KOO25742.1 - 0.068 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Arch_ATPase PF01637.13 KOO25742.1 - 0.092 12.4 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase MMR_HSR1 PF01926.18 KOO25742.1 - 0.097 12.6 0.0 0.26 11.2 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.1 KOO25742.1 - 0.1 12.1 0.1 0.22 11.0 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.1 KOO25742.1 - 0.11 12.3 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain FUN14 PF04930.10 KOO25745.1 - 1.1e-15 57.7 2.4 1.1e-15 57.7 1.7 1.8 2 0 0 2 2 2 1 FUN14 family Dockerin_1 PF00404.13 KOO25745.1 - 0.012 15.2 1.6 0.021 14.5 1.1 1.4 1 0 0 1 1 1 0 Dockerin type I repeat EF-hand_5 PF13202.1 KOO25745.1 - 0.054 12.8 0.7 0.1 11.9 0.5 1.4 1 0 0 1 1 1 0 EF hand 4HBT_3 PF13622.1 KOO25745.1 - 0.065 12.9 0.0 0.084 12.6 0.0 1.1 1 0 0 1 1 1 0 Thioesterase-like superfamily Prefoldin_2 PF01920.15 KOO25745.1 - 0.083 12.6 0.2 0.13 12.0 0.2 1.2 1 0 0 1 1 1 0 Prefoldin subunit cNMP_binding PF00027.24 KOO25746.1 - 9.7e-14 50.9 0.0 2.2e-05 24.1 0.0 2.7 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain FdhE PF04216.7 KOO25746.1 - 0.00016 21.5 3.4 0.00016 21.5 2.4 2.2 1 1 0 2 2 2 1 Protein involved in formate dehydrogenase formation DUF1178 PF06676.6 KOO25746.1 - 0.6 10.3 4.0 0.23 11.6 0.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1178) Glyco_hydro_7 PF00840.15 KOO25747.1 - 2.2e-15 56.0 6.5 7.8e-08 31.1 0.2 3.3 1 1 1 2 2 2 2 Glycosyl hydrolase family 7 Bestrophin PF01062.16 KOO25748.1 - 1.7e-13 50.2 0.0 2.2e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Ank_2 PF12796.2 KOO25749.1 - 7.4e-17 61.4 18.4 5.5e-09 36.2 2.1 2.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO25749.1 - 1.1e-15 57.2 9.7 1.9e-07 31.0 0.6 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO25749.1 - 3e-15 54.8 1.3 0.0019 18.2 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.25 KOO25749.1 - 1e-13 50.3 6.6 0.00038 20.1 0.3 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 KOO25749.1 - 1.6e-11 44.4 0.5 3.7e-08 33.6 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) FCD PF07729.7 KOO25749.1 - 2 8.7 8.2 0.66 10.3 1.9 2.6 2 1 0 2 2 2 0 FCD domain DEAD PF00270.24 KOO25750.1 - 3.3e-42 143.8 0.0 7.5e-42 142.6 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF4217 PF13959.1 KOO25750.1 - 9.3e-21 73.1 0.0 1.7e-20 72.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.26 KOO25750.1 - 4.8e-20 71.1 0.0 9.6e-20 70.2 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO25750.1 - 0.02 14.7 0.0 0.049 13.4 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit TM231 PF10149.4 KOO25751.1 - 5.9e-22 78.0 0.0 4.6e-21 75.1 0.0 1.9 1 1 0 1 1 1 1 Transmembrane protein 231 Translin PF01997.11 KOO25752.1 - 3e-32 111.8 0.0 2.7e-21 76.1 0.0 2.2 2 0 0 2 2 2 2 Translin family gpW PF02831.10 KOO25752.1 - 0.069 12.7 2.7 0.3 10.6 0.0 3.0 3 0 0 3 3 3 0 gpW Ion_trans PF00520.26 KOO25755.1 - 2.9e-170 562.0 56.0 5.5e-51 172.6 5.2 4.3 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 KOO25755.1 - 8.7e-06 24.4 9.0 8.7e-06 24.4 6.2 9.2 8 2 1 9 9 9 7 Polycystin cation channel PT-VENN PF04829.8 KOO25755.1 - 0.2 11.2 0.6 0.42 10.1 0.4 1.6 1 0 0 1 1 1 0 Pre-toxin domain with VENN motif Chloroa_b-bind PF00504.16 KOO25756.1 - 1.8e-31 109.5 0.1 2.5e-31 109.0 0.0 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein MutS_V PF00488.16 KOO25757.1 - 3.9e-26 91.8 0.0 7.4e-26 90.9 0.0 1.3 1 0 0 1 1 1 1 MutS domain V Smr PF01713.16 KOO25757.1 - 8.3e-09 35.5 0.0 4.3e-08 33.2 0.0 2.3 2 0 0 2 2 2 1 Smr domain Myb_DNA-binding PF00249.26 KOO25757.1 - 0.0002 21.3 0.1 0.00041 20.3 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain MAT1 PF06391.8 KOO25757.1 - 3.9 6.9 7.0 7.6 6.0 4.9 1.4 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Mnd1 PF03962.10 KOO25757.1 - 4.5 6.8 7.8 9.8 5.7 5.4 1.5 1 0 0 1 1 1 0 Mnd1 family MFS_1 PF07690.11 KOO25758.1 - 9e-31 106.8 25.5 5.1e-20 71.4 11.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 KOO25758.1 - 6.5e-09 34.8 10.2 3.6e-06 25.8 1.5 3.2 1 1 2 3 3 3 3 Sugar (and other) transporter MFS_1_like PF12832.2 KOO25758.1 - 0.047 13.4 0.4 1.7 8.4 0.1 2.7 2 0 0 2 2 2 0 MFS_1 like family TRI12 PF06609.8 KOO25758.1 - 0.055 11.6 6.7 0.028 12.6 2.7 1.7 1 1 1 2 2 2 0 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.8 KOO25758.1 - 0.13 10.3 9.2 0.043 11.9 4.1 1.7 1 1 1 2 2 2 0 Transmembrane secretion effector Anoctamin PF04547.7 KOO25759.1 - 5.1e-90 302.2 0.8 3.3e-89 299.6 0.5 1.9 1 1 0 1 1 1 1 Calcium-activated chloride channel DUF1282 PF06930.7 KOO25759.1 - 0.0011 18.6 0.4 0.0045 16.6 0.3 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1282) PAN_4 PF14295.1 KOO25762.1 - 0.002 17.8 1.1 0.0052 16.4 0.8 1.8 1 0 0 1 1 1 1 PAN domain IQ PF00612.22 KOO25764.1 - 0.00057 19.3 8.0 0.017 14.6 0.6 3.1 2 0 0 2 2 2 2 IQ calmodulin-binding motif Mito_fiss_reg PF05308.6 KOO25764.1 - 0.034 13.5 1.0 0.062 12.6 0.7 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator DUF3464 PF11947.3 KOO25764.1 - 0.46 9.9 3.5 1.1 8.7 2.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) EF-hand_6 PF13405.1 KOO25765.1 - 2.7e-09 36.1 0.3 0.0036 17.0 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO25765.1 - 2.4e-08 34.0 0.1 5.3e-08 32.8 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO25765.1 - 1.9e-07 29.8 0.1 0.018 14.3 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO25765.1 - 3.1e-06 26.2 0.5 0.011 15.0 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO25765.1 - 4.5e-05 22.9 0.0 9.4e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair Nitroreductase PF00881.19 KOO25766.1 - 2.1e-19 69.9 0.0 2.8e-19 69.5 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.1 KOO25766.1 - 0.054 12.6 0.0 7.7 5.6 0.0 2.2 2 0 0 2 2 2 0 Putative TM nitroreductase DUF2173 PF09941.4 KOO25766.1 - 0.081 12.8 2.7 0.91 9.4 1.7 2.4 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2173) CRAL_TRIO PF00650.15 KOO25768.1 - 1.7e-15 56.8 0.0 2.6e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain TMEM51 PF15345.1 KOO25768.1 - 0.0091 15.7 0.4 0.019 14.6 0.3 1.5 1 0 0 1 1 1 1 Transmembrane protein 51 CRAL_TRIO_N PF03765.10 KOO25768.1 - 0.077 13.1 0.0 0.47 10.6 0.0 2.4 3 0 0 3 3 3 0 CRAL/TRIO, N-terminal domain MatE PF01554.13 KOO25770.1 - 1.8e-30 105.7 21.6 1.5e-21 76.7 5.9 2.3 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.1 KOO25770.1 - 3e-17 62.7 22.9 3.3e-13 49.6 4.5 2.8 3 0 0 3 3 3 2 Polysaccharide biosynthesis C-terminal domain MVIN PF03023.9 KOO25770.1 - 0.0021 16.5 3.1 0.0021 16.5 2.1 2.2 2 0 0 2 2 2 2 MviN-like protein Bromodomain PF00439.20 KOO25771.1 - 6.2e-16 58.0 0.0 9.8e-16 57.4 0.0 1.3 1 0 0 1 1 1 1 Bromodomain PHD PF00628.24 KOO25771.1 - 5.5e-12 45.1 30.9 1.3e-08 34.4 2.2 3.7 4 0 0 4 4 4 2 PHD-finger MBD PF01429.14 KOO25771.1 - 2.2e-07 30.2 0.0 4.2e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Methyl-CpG binding domain zf-HC5HC2H PF13771.1 KOO25771.1 - 0.11 12.7 15.1 0.26 11.4 0.5 2.6 2 0 0 2 2 2 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.1 KOO25771.1 - 0.34 10.9 10.6 1.6 8.7 0.1 2.5 2 0 0 2 2 2 0 PHD-zinc-finger like domain PHD_2 PF13831.1 KOO25771.1 - 0.77 9.1 19.6 0.036 13.3 0.4 3.8 4 0 0 4 4 4 0 PHD-finger tRNA_synt_1c_R2 PF04557.10 KOO25771.1 - 3.9 8.2 5.7 2.8 8.6 2.5 1.8 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 zf-PHD-like PF15446.1 KOO25771.1 - 9.9 5.4 17.4 3.3 6.9 1.0 3.2 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain zf-C3HC4_2 PF13923.1 KOO25772.1 - 1.4e-09 37.7 26.2 4e-06 26.7 7.0 2.9 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO25772.1 - 6e-09 35.4 24.5 6.2e-06 25.7 6.3 2.7 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 KOO25772.1 - 1e-08 34.8 23.8 3.1e-08 33.3 6.5 2.8 2 0 0 2 2 2 2 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.1 KOO25772.1 - 1e-07 31.5 24.4 6.2e-06 25.7 6.9 2.8 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 KOO25772.1 - 4.4e-06 26.3 14.2 6.7e-05 22.5 1.6 2.9 2 1 0 2 2 2 2 RING-type zinc-finger zf-RING_2 PF13639.1 KOO25772.1 - 4.6e-05 23.1 30.1 8.7e-05 22.2 9.6 2.8 2 0 0 2 2 2 2 Ring finger domain zf-RING_4 PF14570.1 KOO25772.1 - 0.00012 21.5 1.9 0.00012 21.5 1.3 4.4 4 0 0 4 4 4 2 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.1 KOO25772.1 - 0.00017 21.2 8.0 0.00017 21.2 5.6 3.2 3 0 0 3 3 3 2 zinc-RING finger domain ZZ PF00569.12 KOO25772.1 - 0.00022 20.6 3.0 0.00022 20.6 2.1 2.6 3 0 0 3 3 3 1 Zinc finger, ZZ type Prok-RING_4 PF14447.1 KOO25772.1 - 0.21 11.1 23.1 0.29 10.7 4.2 3.1 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 AAA PF00004.24 KOO25773.1 - 2.6e-42 144.1 0.0 4.9e-42 143.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO25773.1 - 3.6e-07 30.3 0.0 1.7e-05 24.9 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_2 PF07724.9 KOO25773.1 - 1.5e-06 28.1 0.0 4.5e-06 26.6 0.0 1.7 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 KOO25773.1 - 1.8e-06 28.1 0.0 0.00031 20.9 0.0 2.6 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 KOO25773.1 - 1.6e-05 24.0 0.0 2.8e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 KOO25773.1 - 3.7e-05 23.4 0.1 0.0007 19.3 0.0 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 KOO25773.1 - 0.0005 20.8 0.2 0.0025 18.6 0.0 2.3 2 1 0 2 2 2 1 AAA domain DUF815 PF05673.8 KOO25773.1 - 0.00054 18.9 0.0 0.00096 18.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_19 PF13245.1 KOO25773.1 - 0.00076 19.1 0.1 0.002 17.8 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain TIP49 PF06068.8 KOO25773.1 - 0.00084 18.1 0.0 0.0015 17.3 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus IstB_IS21 PF01695.12 KOO25773.1 - 0.0019 17.6 0.0 0.0036 16.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Sigma54_activat PF00158.21 KOO25773.1 - 0.0021 17.5 0.0 0.0073 15.7 0.0 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_18 PF13238.1 KOO25773.1 - 0.0042 17.4 0.1 0.02 15.1 0.0 2.2 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 KOO25773.1 - 0.0049 17.0 0.0 0.014 15.5 0.0 1.8 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.1 KOO25773.1 - 0.0059 16.4 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 KOO25773.1 - 0.0067 15.6 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 KOO25773.1 - 0.0073 16.1 0.0 0.017 15.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 KOO25773.1 - 0.012 15.5 0.1 0.044 13.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.6 KOO25773.1 - 0.014 14.9 0.0 0.031 13.8 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.1 KOO25773.1 - 0.016 14.7 0.1 0.041 13.4 0.0 1.7 2 0 0 2 2 1 0 AAA domain Zeta_toxin PF06414.7 KOO25773.1 - 0.017 14.2 0.0 0.04 13.0 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin NB-ARC PF00931.17 KOO25773.1 - 0.021 13.7 0.1 0.11 11.3 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain KaiC PF06745.8 KOO25773.1 - 0.024 13.7 0.1 0.094 11.8 0.0 2.0 3 0 0 3 3 3 0 KaiC Arch_ATPase PF01637.13 KOO25773.1 - 0.025 14.2 0.0 0.1 12.2 0.0 2.0 1 1 0 1 1 1 0 Archaeal ATPase AAA_30 PF13604.1 KOO25773.1 - 0.035 13.6 0.1 0.079 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 KOO25773.1 - 0.04 13.1 0.1 0.072 12.3 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Sigma54_activ_2 PF14532.1 KOO25773.1 - 0.047 13.7 0.0 0.18 11.8 0.0 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain Parvo_NS1 PF01057.12 KOO25773.1 - 0.05 12.4 0.0 0.083 11.7 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 TPR_MLP1_2 PF07926.7 KOO25773.1 - 0.052 13.2 0.7 0.087 12.5 0.5 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein AAA_25 PF13481.1 KOO25773.1 - 0.061 12.7 1.4 0.15 11.4 0.1 2.3 2 1 1 3 3 3 0 AAA domain NACHT PF05729.7 KOO25773.1 - 0.083 12.5 0.0 0.21 11.2 0.0 1.7 2 0 0 2 2 1 0 NACHT domain AAA_11 PF13086.1 KOO25773.1 - 0.099 12.1 0.2 0.56 9.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain UPF0079 PF02367.12 KOO25773.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 V-SNARE_C PF12352.3 KOO25774.1 - 6.6e-17 61.3 10.9 2.6e-16 59.4 1.6 2.4 2 0 0 2 2 2 2 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.8 KOO25774.1 - 0.00075 19.1 1.5 0.0047 16.5 0.1 2.6 2 1 1 3 3 3 2 Sec20 YihI PF04220.7 KOO25774.1 - 0.09 12.1 0.4 0.09 12.1 0.3 1.9 2 0 0 2 2 2 0 Der GTPase activator (YihI) KxDL PF10241.4 KOO25774.1 - 2.3 8.1 5.6 1.9 8.4 0.6 3.0 1 1 3 4 4 4 0 Uncharacterized conserved protein Nup54 PF13874.1 KOO25774.1 - 9.5 5.8 13.4 3.5 7.2 2.2 2.9 2 1 1 3 3 3 0 Nucleoporin complex subunit 54 Chloroa_b-bind PF00504.16 KOO25775.1 - 0.062 13.5 0.1 0.4 10.9 0.0 1.9 1 1 1 2 2 2 0 Chlorophyll A-B binding protein Imm7 PF15588.1 KOO25775.1 - 0.12 12.3 0.1 0.21 11.6 0.1 1.4 1 0 0 1 1 1 0 Immunity protein 7 DUF2894 PF11445.3 KOO25775.1 - 1.2 9.3 9.7 3.1 8.0 6.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2894) PPR_2 PF13041.1 KOO25776.1 - 1.8e-44 149.4 0.0 6.6e-07 29.2 0.0 10.8 6 3 5 11 11 11 9 PPR repeat family PPR_3 PF13812.1 KOO25776.1 - 2.5e-42 139.6 27.2 5.4e-06 26.2 0.0 14.0 14 0 0 14 14 14 10 Pentatricopeptide repeat domain PPR PF01535.15 KOO25776.1 - 1.2e-34 115.8 1.6 0.00023 20.9 0.0 13.2 13 1 0 13 13 13 7 PPR repeat PPR_1 PF12854.2 KOO25776.1 - 7.7e-12 44.4 0.0 0.012 15.0 0.0 8.9 10 0 0 10 10 10 3 PPR repeat Smr PF01713.16 KOO25776.1 - 4.1e-06 26.9 0.2 1.3e-05 25.3 0.1 1.9 1 0 0 1 1 1 1 Smr domain Apc3 PF12895.2 KOO25776.1 - 0.0047 17.0 4.5 0.039 14.0 0.1 4.1 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 ECSIT PF06239.6 KOO25776.1 - 0.1 11.4 0.0 2.9 6.6 0.0 2.5 2 0 0 2 2 2 0 Evolutionarily conserved signalling intermediate in Toll pathway Ftsk_gamma PF09397.5 KOO25776.1 - 0.23 11.1 1.0 1.7e+02 2.0 0.0 4.4 5 0 0 5 5 5 0 Ftsk gamma domain SET PF00856.23 KOO25777.1 - 4.2e-20 72.6 0.0 5.3e-19 69.1 0.1 2.5 2 2 0 2 2 2 1 SET domain zf-RING_2 PF13639.1 KOO25778.1 - 1.1e-11 44.3 12.7 2.1e-11 43.4 8.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KOO25778.1 - 3e-08 33.6 7.2 7.5e-08 32.3 5.0 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 KOO25778.1 - 4.1e-08 32.7 9.0 8.1e-08 31.8 6.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO25778.1 - 2.8e-07 30.4 9.3 5.4e-07 29.5 6.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO25778.1 - 5.8e-06 25.8 10.6 9.9e-06 25.1 7.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 KOO25778.1 - 6.4e-05 22.7 5.3 0.00014 21.6 3.7 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.1 KOO25778.1 - 0.00019 21.0 11.4 0.00035 20.2 7.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 KOO25778.1 - 0.0014 18.3 3.3 0.005 16.5 2.5 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-Nse PF11789.3 KOO25778.1 - 0.026 14.0 5.7 0.052 13.0 4.0 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.1 KOO25778.1 - 0.064 12.8 7.3 0.17 11.5 5.0 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.2 KOO25778.1 - 0.068 13.2 9.0 0.14 12.2 6.2 1.5 1 0 0 1 1 1 0 RING-variant domain PAP2 PF01569.16 KOO25779.1 - 9.5e-16 57.6 1.8 3.1e-15 56.0 0.5 2.4 2 0 0 2 2 2 1 PAP2 superfamily Peptidase_M75 PF09375.5 KOO25779.1 - 0.066 12.5 0.3 0.1 11.8 0.2 1.2 1 0 0 1 1 1 0 Imelysin Chloroa_b-bind PF00504.16 KOO25780.1 - 6.9e-27 94.6 0.0 1.2e-26 93.7 0.0 1.3 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Ank_2 PF12796.2 KOO25781.1 - 9.2e-18 64.3 0.0 4.9e-13 49.2 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO25781.1 - 6.7e-16 57.9 0.2 7.6e-10 38.7 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO25781.1 - 5.4e-13 49.0 0.0 1.9e-08 34.5 0.0 2.9 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO25781.1 - 4.5e-11 41.9 0.1 0.0025 17.5 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.1 KOO25781.1 - 4.8e-10 38.6 0.0 0.16 12.2 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat ABC_tran PF00005.22 KOO25782.1 - 9.1e-20 71.3 0.0 1.4e-19 70.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 KOO25782.1 - 0.00016 21.7 0.0 0.66 9.8 0.0 2.1 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 KOO25782.1 - 0.00087 18.5 0.0 0.0032 16.6 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function, DUF258 SMC_N PF02463.14 KOO25782.1 - 0.0049 16.1 0.0 0.28 10.3 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_33 PF13671.1 KOO25782.1 - 0.009 15.8 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 KOO25782.1 - 0.021 14.3 0.0 0.047 13.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_17 PF13207.1 KOO25782.1 - 0.051 14.3 0.0 0.1 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 KOO25782.1 - 0.12 11.7 0.2 0.18 11.1 0.2 1.2 1 0 0 1 1 1 0 AAA-like domain SbcCD_C PF13558.1 KOO25782.1 - 0.15 11.9 0.2 0.5 10.3 0.1 1.9 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Nol1_Nop2_Fmu PF01189.12 KOO25783.1 - 1.9e-87 293.2 0.0 3e-87 292.6 0.0 1.3 1 0 0 1 1 1 1 NOL1/NOP2/sun family PCMT PF01135.14 KOO25783.1 - 2e-05 24.2 0.0 3.2e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 KOO25783.1 - 0.0002 20.9 0.0 0.00037 20.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO25783.1 - 0.00032 21.2 0.2 0.00089 19.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 KOO25783.1 - 0.0096 15.3 0.0 0.017 14.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.13 KOO25783.1 - 0.0098 15.0 0.0 0.018 14.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF938 PF06080.7 KOO25783.1 - 0.018 14.5 0.0 0.034 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) FtsJ PF01728.14 KOO25783.1 - 0.049 13.6 0.0 0.11 12.4 0.0 1.7 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_11 PF08241.7 KOO25783.1 - 0.091 13.2 0.0 0.24 11.8 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Fibrillarin PF01269.12 KOO25783.1 - 0.13 11.1 0.0 0.23 10.3 0.0 1.3 1 0 0 1 1 1 0 Fibrillarin AAA_12 PF13087.1 KOO25784.1 - 7.6e-48 162.5 0.0 1.2e-47 161.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain Abhydrolase_6 PF12697.2 KOO25784.1 - 1.1e-22 81.0 0.2 1.1e-22 81.0 0.2 3.9 3 2 0 3 3 1 1 Alpha/beta hydrolase family AAA_11 PF13086.1 KOO25784.1 - 2.6e-13 50.1 0.0 5.7e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain Abhydrolase_5 PF12695.2 KOO25784.1 - 9.5e-11 41.6 0.2 1.3e-09 37.9 0.2 2.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family AAA_19 PF13245.1 KOO25784.1 - 1e-09 37.9 0.5 1e-09 37.9 0.3 3.6 3 0 0 3 3 2 1 Part of AAA domain Abhydrolase_1 PF00561.15 KOO25784.1 - 2.3e-09 37.1 0.3 5e-08 32.7 0.0 2.5 2 1 0 2 2 2 1 alpha/beta hydrolase fold AAA_30 PF13604.1 KOO25784.1 - 2.4e-07 30.5 0.1 2.4e-07 30.5 0.0 2.3 3 0 0 3 3 2 1 AAA domain WW PF00397.21 KOO25784.1 - 1.7e-06 27.7 0.1 3.4e-06 26.7 0.1 1.5 1 0 0 1 1 1 1 WW domain Abhydrolase_3 PF07859.8 KOO25784.1 - 0.00028 20.5 3.0 0.0064 16.0 0.0 3.2 3 0 0 3 3 3 1 alpha/beta hydrolase fold DUF2075 PF09848.4 KOO25784.1 - 0.00068 18.7 0.6 0.093 11.6 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Esterase PF00756.15 KOO25784.1 - 0.00085 18.8 0.0 0.0016 17.8 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.16 KOO25784.1 - 0.0011 18.2 0.0 0.012 14.8 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family PPR_3 PF13812.1 KOO25784.1 - 0.0023 18.0 1.3 0.029 14.6 0.0 3.3 3 0 0 3 3 2 1 Pentatricopeptide repeat domain Ndr PF03096.9 KOO25784.1 - 0.0036 15.8 0.0 0.0066 14.9 0.0 1.3 1 0 0 1 1 1 1 Ndr family AAA_16 PF13191.1 KOO25784.1 - 0.0076 16.2 0.1 0.0076 16.2 0.1 3.8 5 1 1 6 6 5 1 AAA ATPase domain NACHT PF05729.7 KOO25784.1 - 0.0095 15.6 0.1 0.029 14.0 0.0 1.8 2 0 0 2 2 1 1 NACHT domain PhoH PF02562.11 KOO25784.1 - 0.015 14.5 0.0 0.038 13.2 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein Mg_chelatase PF01078.16 KOO25784.1 - 0.024 13.8 0.0 0.05 12.7 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_22 PF13401.1 KOO25784.1 - 0.028 14.5 0.1 0.15 12.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 KOO25784.1 - 0.04 13.6 0.0 0.089 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.24 KOO25784.1 - 0.076 13.2 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 KOO25784.1 - 0.14 12.9 0.2 0.73 10.6 0.0 2.3 2 0 0 2 2 1 0 AAA domain DUF2048 PF09752.4 KOO25784.1 - 0.17 10.7 0.8 0.78 8.5 0.2 2.2 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2048) AAA_33 PF13671.1 KOO25784.1 - 0.19 11.5 0.0 0.19 11.5 0.0 3.2 3 1 0 3 3 2 0 AAA domain DnaJ PF00226.26 KOO25786.1 - 3e-06 26.8 0.0 8.5e-06 25.4 0.0 1.7 1 1 0 1 1 1 1 DnaJ domain MIT PF04212.13 KOO25787.1 - 1.4e-13 50.4 1.3 1.7e-13 50.1 0.9 1.1 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain TPR_11 PF13414.1 KOO25787.1 - 0.013 15.1 1.6 0.024 14.2 0.6 1.8 1 1 1 2 2 2 0 TPR repeat TPR_2 PF07719.12 KOO25787.1 - 0.016 15.0 1.0 0.041 13.8 0.3 1.9 1 1 1 2 2 2 0 Tetratricopeptide repeat Mu-like_gpT PF10124.4 KOO25787.1 - 0.021 13.8 0.0 0.025 13.5 0.0 1.1 1 0 0 1 1 1 0 Mu-like prophage major head subunit gpT Ribosomal_L21p PF00829.16 KOO25788.1 - 5.8e-28 96.8 0.0 7.5e-28 96.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein Laminin_G_3 PF13385.1 KOO25789.1 - 2.4e-33 115.6 0.0 4.5e-17 62.7 0.0 2.3 2 0 0 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.19 KOO25789.1 - 1.5e-10 41.1 0.0 0.00023 21.2 0.0 2.8 2 1 0 2 2 2 2 Laminin G domain Sialidase PF02973.11 KOO25789.1 - 0.0032 16.4 0.0 0.026 13.4 0.0 2.0 2 0 0 2 2 2 1 Sialidase, N-terminal domain Pentaxin PF00354.12 KOO25789.1 - 0.0035 16.8 0.0 1.6 8.0 0.0 2.2 2 0 0 2 2 2 2 Pentaxin family Pkinase PF00069.20 KOO25790.1 - 5.9e-56 189.5 0.0 9e-56 188.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25790.1 - 3.6e-30 104.9 0.0 5.2e-30 104.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO25790.1 - 3e-06 27.1 0.2 0.0002 21.1 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO25790.1 - 0.002 17.1 0.0 0.0032 16.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 KOO25790.1 - 0.0045 16.3 0.1 0.018 14.4 0.0 1.9 2 0 0 2 2 2 1 RIO1 family YrbL-PhoP_reg PF10707.4 KOO25790.1 - 0.05 12.9 0.0 0.092 12.0 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Kdo PF06293.9 KOO25790.1 - 0.063 12.3 0.0 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FlgN PF05130.7 KOO25791.1 - 0.0075 16.5 4.1 0.016 15.4 2.9 1.5 1 0 0 1 1 1 1 FlgN protein BRE PF06113.7 KOO25791.1 - 0.18 10.8 0.0 0.26 10.3 0.0 1.1 1 0 0 1 1 1 0 Brain and reproductive organ-expressed protein (BRE) MFS_1 PF07690.11 KOO25792.1 - 6e-08 31.7 37.2 8.9e-07 27.9 10.7 2.8 2 1 0 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.11 KOO25792.1 - 0.00018 21.0 7.0 0.0006 19.3 4.8 1.9 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 DUF962 PF06127.6 KOO25792.1 - 0.13 12.1 0.7 1.2 9.0 0.1 2.8 2 2 0 2 2 2 0 Protein of unknown function (DUF962) SBBP PF06739.6 KOO25793.1 - 4.5e-05 23.1 18.6 0.0023 17.6 2.6 3.5 3 0 0 3 3 3 2 Beta-propeller repeat FAD_binding_9 PF08021.6 KOO25793.1 - 6.7 6.7 8.3 47 3.9 0.2 3.1 3 0 0 3 3 3 0 Siderophore-interacting FAD-binding domain SAP PF02037.22 KOO25794.1 - 1.2e-15 56.5 0.9 1.3e-15 56.4 0.6 1.0 1 0 0 1 1 1 1 SAP domain HeH PF12949.2 KOO25794.1 - 6.6e-05 22.3 0.2 0.00017 21.0 0.1 1.6 1 1 0 1 1 1 1 HeH/LEM domain Telomere_Sde2_2 PF13297.1 KOO25794.1 - 0.056 12.7 0.2 0.057 12.6 0.2 1.1 1 0 0 1 1 1 0 Telomere stability C-terminal Rho_N PF07498.7 KOO25794.1 - 0.17 11.7 0.9 0.34 10.7 0.6 1.6 1 1 0 1 1 1 0 Rho termination factor, N-terminal domain HA2 PF04408.18 KOO25795.1 - 1.4e-22 79.6 1.0 2.2e-22 79.0 0.1 1.8 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.26 KOO25795.1 - 9.5e-12 44.6 0.1 2.7e-11 43.1 0.1 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOO25795.1 - 0.00059 19.3 0.0 0.0015 18.0 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.1 KOO25795.1 - 0.012 15.3 0.5 0.012 15.3 0.3 2.9 4 0 0 4 4 4 0 Part of AAA domain AAA_22 PF13401.1 KOO25795.1 - 0.014 15.5 0.3 0.053 13.6 0.0 2.2 2 1 0 2 2 2 0 AAA domain KaiC PF06745.8 KOO25795.1 - 0.015 14.3 0.0 0.027 13.5 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_11 PF13086.1 KOO25795.1 - 0.033 13.7 0.1 1.8 8.1 0.0 2.8 2 1 1 3 3 3 0 AAA domain Pkinase PF00069.20 KOO25796.1 - 1.1e-61 208.2 0.0 1.3e-61 208.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25796.1 - 7.2e-32 110.4 0.0 9.5e-32 110.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 KOO25796.1 - 0.0063 15.8 0.1 0.0096 15.2 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 KOO25796.1 - 0.0067 15.5 0.0 0.0093 15.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 KOO25796.1 - 0.031 13.2 0.0 0.052 12.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.18 KOO25796.1 - 0.1 12.3 0.3 0.23 11.1 0.2 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Myb_DNA-binding PF00249.26 KOO25797.1 - 3.6e-12 46.1 0.0 9.6e-12 44.7 0.0 1.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_CC_LHEQLE PF14379.1 KOO25797.1 - 0.0025 17.3 14.6 0.0025 17.3 10.1 2.6 2 1 1 3 3 3 1 MYB-CC type transfactor, LHEQLE motif DUF481 PF04338.7 KOO25797.1 - 0.0066 16.1 0.2 0.012 15.3 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF481 AMP-binding_C_2 PF14535.1 KOO25797.1 - 0.41 10.7 1.8 1.2 9.2 1.1 1.8 1 1 1 2 2 2 0 AMP-binding enzyme C-terminal domain PBP1_TM PF14812.1 KOO25797.1 - 0.81 10.0 7.5 1.6 9.0 5.2 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Na_trans_assoc PF06512.8 KOO25797.1 - 0.94 9.3 12.3 1.5 8.6 8.5 1.3 1 0 0 1 1 1 0 Sodium ion transport-associated NOA36 PF06524.7 KOO25797.1 - 5.6 6.1 7.6 14 4.8 5.3 1.6 1 0 0 1 1 1 0 NOA36 protein PTE PF02126.13 KOO25798.1 - 2.5e-22 79.2 0.0 3.2e-22 78.9 0.0 1.1 1 0 0 1 1 1 1 Phosphotriesterase family DUF718 PF05336.8 KOO25799.1 - 0.0033 17.1 0.0 0.0085 15.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF718) DUF4350 PF14258.1 KOO25799.1 - 0.06 13.5 0.0 0.27 11.4 0.0 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4350) zf-H2C2_5 PF13909.1 KOO25799.1 - 0.28 11.4 1.2 0.56 10.5 0.8 1.4 1 0 0 1 1 1 0 C2H2-type zinc-finger domain Borrelia_P83 PF05262.6 KOO25799.1 - 2.4 6.3 14.2 3.5 5.7 9.8 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF4449 PF14613.1 KOO25799.1 - 8.5 6.2 11.1 4.1 7.3 1.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF4449) EF-hand_8 PF13833.1 KOO25800.1 - 2.2e-17 62.3 8.8 6.1e-06 25.7 0.1 8.9 9 1 1 10 10 10 3 EF-hand domain pair EF-hand_7 PF13499.1 KOO25800.1 - 7e-17 61.3 3.6 0.035 14.2 0.0 7.3 7 0 0 7 7 7 5 EF-hand domain pair EF-hand_6 PF13405.1 KOO25800.1 - 2.1e-12 45.7 8.7 0.024 14.5 0.0 6.4 6 0 0 6 6 6 4 EF-hand domain EF-hand_1 PF00036.27 KOO25800.1 - 6.2e-12 43.9 6.2 0.006 15.8 0.0 6.3 6 0 0 6 6 6 4 EF hand HSBP1 PF06825.7 KOO25800.1 - 0.082 12.4 0.2 0.88 9.1 0.0 2.5 2 0 0 2 2 2 0 Heat shock factor binding protein 1 EF-hand_5 PF13202.1 KOO25800.1 - 0.13 11.6 9.3 5.6 6.4 0.0 4.3 4 0 0 4 4 4 0 EF hand NAD_binding_10 PF13460.1 KOO25802.1 - 1.6e-07 31.4 0.1 2.6e-07 30.8 0.1 1.3 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 KOO25802.1 - 5.6e-05 22.4 0.0 6.9e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family 2OG-FeII_Oxy_3 PF13640.1 KOO25804.1 - 1.6e-09 38.1 0.0 3.2e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Oxygenase-NA PF09859.4 KOO25804.1 - 0.021 14.1 0.1 0.035 13.4 0.1 1.4 1 1 0 1 1 1 0 Oxygenase, catalysing oxidative methylation of damaged DNA ABC_tran PF00005.22 KOO25805.1 - 9.3e-45 152.2 0.0 9e-24 84.3 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 KOO25805.1 - 6.4e-43 147.1 20.4 7.7e-22 77.9 3.2 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.1 KOO25805.1 - 7.2e-10 39.2 0.0 0.37 10.6 0.0 4.2 4 0 0 4 4 4 3 AAA domain AAA_29 PF13555.1 KOO25805.1 - 9.9e-05 21.7 2.8 0.14 11.7 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 KOO25805.1 - 0.00026 20.2 0.6 0.53 9.4 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_16 PF13191.1 KOO25805.1 - 0.00074 19.5 9.0 0.051 13.5 0.4 3.2 2 1 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.14 KOO25805.1 - 0.0008 18.6 3.9 0.22 10.7 0.0 3.5 3 1 1 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 KOO25805.1 - 0.0014 18.7 1.3 2 8.5 0.1 3.3 2 1 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.18 KOO25805.1 - 0.0064 16.4 1.2 1.1 9.2 0.1 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 KOO25805.1 - 0.014 15.2 4.6 0.16 11.7 0.3 2.3 2 0 0 2 2 2 0 Dynamin family Zeta_toxin PF06414.7 KOO25805.1 - 0.014 14.4 0.5 5 6.1 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_17 PF13207.1 KOO25805.1 - 0.017 15.9 0.2 1.9 9.3 0.0 2.9 3 0 0 3 3 2 0 AAA domain AAA_10 PF12846.2 KOO25805.1 - 0.028 13.8 0.2 3.7 6.9 0.1 2.4 2 0 0 2 2 2 0 AAA-like domain Miro PF08477.8 KOO25805.1 - 0.053 14.0 1.8 6.7 7.2 0.1 2.4 2 0 0 2 2 2 0 Miro-like protein AAA_18 PF13238.1 KOO25805.1 - 0.092 13.0 0.3 20 5.4 0.0 2.7 3 0 0 3 3 2 0 AAA domain ABC_ATPase PF09818.4 KOO25805.1 - 0.14 10.7 0.1 0.35 9.4 0.1 1.6 1 0 0 1 1 1 0 Predicted ATPase of the ABC class DUF815 PF05673.8 KOO25805.1 - 0.37 9.6 1.5 3.5 6.4 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_25 PF13481.1 KOO25805.1 - 0.43 9.9 6.8 0.92 8.8 0.1 3.1 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.12 KOO25805.1 - 5.9 6.6 4.2 28 4.4 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF87 Amino_oxidase PF01593.19 KOO25806.1 - 1e-60 206.1 8.3 9.9e-60 202.8 5.8 2.5 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 KOO25806.1 - 3.1e-07 30.3 0.4 8.8e-07 28.8 0.3 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 KOO25806.1 - 1.1e-06 28.5 1.8 0.00028 20.6 0.1 2.6 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 KOO25806.1 - 7.1e-05 22.9 1.6 0.016 15.2 0.5 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 KOO25806.1 - 0.0024 16.9 0.5 0.0046 16.0 0.4 1.4 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.9 KOO25806.1 - 0.07 11.5 0.4 1.5 7.2 0.3 2.2 2 0 0 2 2 2 0 HI0933-like protein DAO PF01266.19 KOO25806.1 - 0.23 10.2 6.1 1.2 8.0 4.2 2.0 1 1 0 1 1 1 0 FAD dependent oxidoreductase DUF3302 PF11742.3 KOO25809.1 - 0.16 11.8 0.0 0.16 11.8 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3302) DUF998 PF06197.8 KOO25809.1 - 1.1 8.5 8.5 1.8 7.8 5.9 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF998) BPD_transp_2 PF02653.11 KOO25809.1 - 1.5 7.6 9.5 1.9 7.3 5.9 1.6 1 1 1 2 2 2 0 Branched-chain amino acid transport system / permease component cNMP_binding PF00027.24 KOO25810.1 - 2.3e-08 33.7 0.0 4e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain PAP_fibrillin PF04755.7 KOO25811.1 - 0.00012 21.9 0.1 0.0081 15.8 0.0 2.1 2 0 0 2 2 2 2 PAP_fibrillin LRR_4 PF12799.2 KOO25812.1 - 8.2e-13 47.6 1.6 1.2e-05 24.7 0.0 3.5 2 2 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO25812.1 - 8.9e-09 34.9 0.9 0.00023 20.8 0.1 3.3 2 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 KOO25812.1 - 4.3e-06 26.0 2.5 5.1 7.5 0.0 5.2 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_7 PF13504.1 KOO25812.1 - 7e-05 22.3 5.6 3.9 8.0 0.0 5.4 4 1 0 4 4 4 1 Leucine rich repeat LRR_6 PF13516.1 KOO25812.1 - 0.002 17.9 0.1 40 4.7 0.0 4.9 5 1 0 5 5 5 0 Leucine Rich repeat LRR_9 PF14580.1 KOO25812.1 - 0.058 12.9 0.0 0.098 12.2 0.0 1.3 1 0 0 1 1 1 0 Leucine-rich repeat Dopey_N PF04118.9 KOO25813.1 - 7.9e-57 192.3 0.0 2.2e-50 171.2 0.0 2.1 2 0 0 2 2 2 2 Dopey, N-terminal Ion_trans PF00520.26 KOO25813.1 - 3.3e-17 62.4 0.3 5.3e-17 61.7 0.2 1.3 1 0 0 1 1 1 1 Ion transport protein Methyltransf_11 PF08241.7 KOO25813.1 - 7.1e-16 58.4 0.0 1.5e-15 57.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO25813.1 - 1e-15 57.9 0.0 2.7e-15 56.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Ion_trans_2 PF07885.11 KOO25813.1 - 5.5e-12 45.2 1.3 1.2e-11 44.1 0.9 1.5 1 0 0 1 1 1 1 Ion channel Methyltransf_26 PF13659.1 KOO25813.1 - 9.4e-11 41.7 2.2 1.4e-10 41.2 0.4 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO25813.1 - 2.2e-10 40.8 0.0 4.7e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO25813.1 - 5.5e-10 39.8 0.0 1.2e-09 38.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO25813.1 - 9.9e-09 35.1 0.0 2e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO25813.1 - 2.1e-08 33.9 0.0 3.7e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO25813.1 - 2.9e-08 33.1 0.0 5.2e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF938 PF06080.7 KOO25813.1 - 0.00017 21.1 0.0 0.0003 20.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF938) MTS PF05175.9 KOO25813.1 - 0.025 13.9 0.0 0.048 13.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_16 PF10294.4 KOO25813.1 - 0.047 13.1 0.0 0.089 12.2 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_29 PF03141.11 KOO25813.1 - 0.049 11.9 0.0 0.078 11.3 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Lig_chan PF00060.21 KOO25813.1 - 0.057 13.1 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Ligand-gated ion channel Dicistro_VP4 PF11492.3 KOO25814.1 - 0.11 12.5 1.7 0.2 11.6 0.2 2.0 2 0 0 2 2 2 0 Cricket paralysis virus, VP4 DUF581 PF04570.9 KOO25816.1 - 3e-06 26.4 0.5 5.1e-06 25.6 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF581) WD40 PF00400.27 KOO25817.1 - 1.5e-07 30.9 5.0 0.1 12.5 0.0 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat BCIP PF13862.1 KOO25818.1 - 3e-27 95.3 0.0 3.5e-27 95.1 0.0 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein Methyltransf_21 PF05050.7 KOO25819.1 - 1.3e-06 28.4 0.0 4.3e-06 26.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase FkbM domain NUDIX PF00293.23 KOO25820.1 - 4.4e-07 29.6 0.1 8.9e-07 28.6 0.1 1.5 1 1 0 1 1 1 1 NUDIX domain RPEL PF02755.10 KOO25821.1 - 0.00052 19.2 2.3 0.068 12.5 1.4 2.4 2 0 0 2 2 2 2 RPEL repeat Ribosomal_S22 PF08136.6 KOO25823.1 - 0.019 15.1 0.6 0.044 13.9 0.4 1.6 1 0 0 1 1 1 0 30S ribosomal protein subunit S22 family DUF1505 PF07403.6 KOO25823.1 - 0.02 14.8 0.4 0.035 14.0 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1505) DIM PF08194.7 KOO25823.1 - 0.072 13.0 0.6 0.13 12.2 0.4 1.5 1 0 0 1 1 1 0 DIM protein Mg_trans_NIPA PF05653.9 KOO25825.1 - 4e-13 48.9 0.9 2.6e-09 36.4 0.0 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EF-hand_5 PF13202.1 KOO25825.1 - 0.00019 20.5 0.0 0.00035 19.7 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KOO25825.1 - 0.00033 19.7 0.0 0.0006 18.9 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO25825.1 - 0.04 13.8 0.0 0.086 12.7 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.1 KOO25825.1 - 0.046 13.8 0.0 0.078 13.1 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_8 PF13833.1 KOO25825.1 - 0.21 11.2 0.0 0.35 10.5 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair C2 PF00168.25 KOO25826.1 - 4.9e-15 55.1 0.0 8.8e-15 54.3 0.0 1.4 1 0 0 1 1 1 1 C2 domain Utp12 PF04003.7 KOO25827.1 - 0.00058 19.7 1.7 0.043 13.7 0.0 2.7 3 0 0 3 3 3 2 Dip2/Utp12 Family LRR_6 PF13516.1 KOO25828.1 - 1.1e-16 58.9 19.8 0.012 15.5 0.0 10.1 10 0 0 10 10 10 6 Leucine Rich repeat EF-hand_1 PF00036.27 KOO25828.1 - 9.7e-12 43.2 2.5 9e-07 27.7 0.3 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO25828.1 - 3.6e-08 32.6 0.1 0.013 15.3 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO25828.1 - 3.8e-08 33.3 0.1 8.1e-08 32.2 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair SAM_1 PF00536.25 KOO25828.1 - 1.4e-07 31.5 0.0 2.9e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) EF-hand_8 PF13833.1 KOO25828.1 - 2.5e-07 30.2 4.1 1.8e-06 27.4 0.1 2.8 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO25828.1 - 6.4e-07 28.4 0.2 0.0013 18.0 0.0 2.6 2 0 0 2 2 2 2 EF hand LRR_1 PF00560.28 KOO25828.1 - 1.3e-06 27.5 3.2 56 4.3 0.1 7.7 7 1 0 7 7 7 0 Leucine Rich Repeat LRR_4 PF12799.2 KOO25828.1 - 3.6e-06 26.4 2.3 9.1 6.0 0.0 6.5 6 1 0 6 6 6 1 Leucine Rich repeats (2 copies) SAM_2 PF07647.12 KOO25828.1 - 7e-06 25.7 0.0 2.2e-05 24.1 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) LRR_7 PF13504.1 KOO25828.1 - 0.0028 17.5 7.5 40 5.0 0.1 7.3 8 0 0 8 8 6 0 Leucine rich repeat EF-hand_4 PF12763.2 KOO25828.1 - 0.1 12.3 0.5 0.21 11.3 0.0 1.7 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand HMG_box PF00505.14 KOO25830.1 - 1.7e-19 69.8 4.4 8.3e-12 45.2 0.4 2.6 2 1 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO25830.1 - 3.5e-14 52.9 5.4 2.8e-09 37.2 0.5 2.2 2 0 0 2 2 2 2 HMG-box domain DUF4654 PF15547.1 KOO25830.1 - 0.0017 18.6 0.3 0.13 12.5 0.1 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF4654) Macro PF01661.16 KOO25830.1 - 0.011 15.5 0.0 0.03 14.2 0.0 1.7 2 0 0 2 2 2 0 Macro domain MSP1a PF11670.3 KOO25830.1 - 0.084 12.6 0.1 11 5.8 0.0 2.2 1 1 1 2 2 2 0 Major surface protein 1a (MSP1a) DUF3106 PF11304.3 KOO25830.1 - 0.11 12.9 1.7 12 6.4 0.0 2.8 3 1 0 3 3 3 0 Protein of unknown function (DUF3106) LTV PF04180.9 KOO25831.1 - 1.8e-13 50.8 0.0 1.8e-13 50.8 0.0 2.0 2 0 0 2 2 2 1 Low temperature viability protein GSHPx PF00255.14 KOO25831.1 - 9.3e-06 24.9 0.0 1.8e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione peroxidase CDK2AP PF09806.4 KOO25832.1 - 0.46 10.6 6.0 0.36 11.0 2.9 1.8 1 1 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein zf-DHHC PF01529.15 KOO25834.1 - 3.5e-34 117.6 16.2 3.5e-34 117.6 11.3 2.2 1 1 1 2 2 2 1 DHHC palmitoyltransferase DUF588 PF04535.7 KOO25834.1 - 0.00065 19.2 2.5 0.0016 17.9 1.7 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF588) DUF2306 PF10067.4 KOO25834.1 - 6.5 6.9 8.8 1 9.5 1.2 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2306) RRM_1 PF00076.17 KOO25835.1 - 1.6e-14 53.2 0.1 4.3e-14 51.8 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO25835.1 - 1.8e-12 47.0 0.0 2e-11 43.6 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO25835.1 - 4.9e-08 32.6 0.2 1.1e-07 31.5 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RE_Bpu10I PF09549.5 KOO25835.1 - 0.91 9.0 3.3 14 5.1 0.2 2.5 3 0 0 3 3 3 0 Bpu10I restriction endonuclease Paramyxo_ncap PF00973.14 KOO25835.1 - 4.1 5.9 7.2 1.7 7.2 0.7 2.1 2 0 0 2 2 2 0 Paramyxovirus nucleocapsid protein Ras PF00071.17 KOO25836.1 - 4e-19 68.5 0.0 4.6e-19 68.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO25836.1 - 0.00022 21.6 0.0 0.00024 21.5 0.0 1.1 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO25836.1 - 0.0013 17.9 0.0 0.0015 17.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family DAP3 PF10236.4 KOO25836.1 - 0.093 11.6 0.0 0.093 11.6 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 WD40 PF00400.27 KOO25837.1 - 9.5e-18 63.3 5.2 0.00014 21.5 0.0 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat BBS2_C PF14782.1 KOO25837.1 - 0.14 10.6 0.8 0.24 9.8 0.6 1.3 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal DUF721 PF05258.7 KOO25838.1 - 0.097 12.8 0.1 0.15 12.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF721) Pkinase PF00069.20 KOO25839.1 - 7e-32 110.6 0.0 1e-31 110.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25839.1 - 2.8e-27 95.4 0.0 4.1e-27 94.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_4 PF13637.1 KOO25839.1 - 9.2e-22 77.0 2.0 6.7e-09 36.0 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO25839.1 - 1.4e-21 76.5 0.0 2.4e-12 47.0 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO25839.1 - 4.8e-19 67.1 0.1 2.5e-07 30.1 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 KOO25839.1 - 1.1e-14 54.0 0.8 3.1e-11 43.1 0.1 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) zf-C3HC4_3 PF13920.1 KOO25839.1 - 2e-11 43.3 9.0 3.5e-11 42.5 6.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Ank_3 PF13606.1 KOO25839.1 - 8.4e-11 41.0 0.0 7e-05 22.7 0.0 4.5 4 0 0 4 4 4 1 Ankyrin repeat zf-C3HC4_2 PF13923.1 KOO25839.1 - 2.5e-07 30.6 9.1 4.7e-07 29.7 6.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-MIZ PF02891.15 KOO25839.1 - 0.058 12.9 5.6 0.11 12.0 3.8 1.4 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger APH PF01636.18 KOO25839.1 - 0.08 12.6 23.3 0.027 14.2 11.0 2.6 2 1 0 2 2 2 0 Phosphotransferase enzyme family Rieske PF00355.21 KOO25840.1 - 7.8e-07 28.5 0.0 1.3e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain DUF2177 PF09945.4 KOO25841.1 - 0.0065 16.4 3.0 0.016 15.1 2.1 1.8 1 0 0 1 1 1 1 Predicted membrane protein (DUF2177) FA_hydroxylase PF04116.8 KOO25842.1 - 5.3e-13 49.3 21.0 5.3e-13 49.3 14.5 2.3 3 0 0 3 3 3 1 Fatty acid hydroxylase superfamily Cad PF03596.8 KOO25842.1 - 0.12 12.0 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Cadmium resistance transporter Thioredoxin_8 PF13905.1 KOO25843.1 - 6.9e-23 80.5 0.0 9.4e-23 80.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.5 KOO25843.1 - 5e-11 42.3 0.0 6.5e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 KOO25843.1 - 6.1e-10 38.8 0.0 8.6e-10 38.3 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.1 KOO25843.1 - 1.2e-06 28.7 0.0 1.7e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.1 KOO25843.1 - 5.2e-06 26.0 0.0 0.00028 20.4 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin Thioredoxin PF00085.15 KOO25843.1 - 1.9e-05 24.2 0.0 5e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_7 PF13899.1 KOO25843.1 - 0.00077 19.4 0.0 0.0029 17.5 0.1 2.0 2 1 0 2 2 2 1 Thioredoxin-like SCO1-SenC PF02630.9 KOO25843.1 - 0.0026 17.3 0.0 0.0035 16.9 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC Glutaredoxin PF00462.19 KOO25843.1 - 0.01 15.8 0.1 0.042 13.8 0.0 2.0 2 1 0 2 2 2 0 Glutaredoxin TraF PF13728.1 KOO25843.1 - 0.012 15.1 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Cache_3 PF14827.1 KOO25843.1 - 0.079 12.8 0.0 3.9 7.3 0.0 2.2 2 0 0 2 2 2 0 Sensory domain of two-component sensor kinase Arm PF00514.18 KOO25844.1 - 4.4e-33 111.9 34.7 2.7e-07 30.1 0.2 13.9 13 0 0 13 13 13 10 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 KOO25844.1 - 0.0028 18.0 0.9 0.0028 18.0 0.6 10.1 6 3 3 11 11 11 3 HEAT-like repeat HEAT_2 PF13646.1 KOO25844.1 - 0.0041 17.3 2.1 0.0041 17.3 1.4 8.0 5 2 3 8 8 8 4 HEAT repeats Atx10homo_assoc PF09759.4 KOO25844.1 - 0.069 12.8 0.0 14 5.5 0.0 4.1 5 0 0 5 5 5 0 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.8 KOO25844.1 - 0.16 11.0 0.0 40 3.1 0.0 3.4 3 1 1 4 4 4 0 Armadillo-like HEAT PF02985.17 KOO25844.1 - 8.9 6.6 9.7 8.1 6.8 0.0 5.7 5 1 1 6 6 6 0 HEAT repeat Peptidase_C2 PF00648.16 KOO25845.1 - 1.6e-65 221.0 0.0 2.5e-65 220.4 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease EF-hand_1 PF00036.27 KOO25847.1 - 1e-07 30.7 0.2 0.0014 17.7 0.1 4.1 5 0 0 5 5 5 2 EF hand EF-hand_6 PF13405.1 KOO25847.1 - 3.9e-05 23.1 0.0 1.6 8.7 0.0 4.2 5 0 0 5 5 5 2 EF-hand domain EF-hand_7 PF13499.1 KOO25847.1 - 5.9e-05 23.1 0.3 0.32 11.1 0.0 3.2 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO25847.1 - 0.0013 18.0 3.7 0.034 13.4 0.0 3.9 4 1 0 4 4 4 1 EF hand EF-hand_8 PF13833.1 KOO25847.1 - 0.014 14.9 0.2 0.33 10.5 0.1 2.5 2 0 0 2 2 2 0 EF-hand domain pair DNA_pol_B PF00136.16 KOO25848.1 - 6.8e-51 173.4 0.0 1.4e-32 113.0 0.0 2.1 2 0 0 2 2 2 2 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 KOO25848.1 - 1.5e-07 30.6 0.0 1.5e-06 27.3 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase family B, exonuclease domain Na_H_Exchanger PF00999.16 KOO25849.1 - 1.6e-51 175.0 27.9 2.3e-51 174.4 19.3 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family FKBP_C PF00254.23 KOO25850.1 - 1.5e-30 105.0 0.0 2.3e-30 104.4 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase PepSY_2 PF13670.1 KOO25850.1 - 5.2 7.0 5.8 28 4.6 4.0 2.2 1 1 0 1 1 1 0 Peptidase propeptide and YPEB domain Methyltransf_21 PF05050.7 KOO25851.1 - 0.0011 18.8 0.0 0.0047 16.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase FkbM domain AMP-binding PF00501.23 KOO25852.1 - 1.6e-41 142.1 0.9 2.7e-41 141.3 0.6 1.4 1 0 0 1 1 1 1 AMP-binding enzyme MGS PF02142.17 KOO25852.1 - 0.09 12.7 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 MGS-like domain DUF4350 PF14258.1 KOO25852.1 - 0.095 12.9 0.3 13 6.0 0.0 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4350) Prim-Pol PF09250.6 KOO25852.1 - 0.11 12.4 0.3 0.45 10.4 0.1 1.9 1 1 1 2 2 2 0 Bifunctional DNA primase/polymerase, N-terminal Ank_2 PF12796.2 KOO25853.1 - 7e-37 125.6 9.5 1.1e-10 41.7 0.2 5.3 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO25853.1 - 7.3e-33 112.3 6.5 4.4e-09 36.6 0.0 6.5 4 1 2 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO25853.1 - 5e-32 109.1 16.9 2.8e-07 30.5 0.3 6.3 5 1 1 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.25 KOO25853.1 - 4.5e-24 83.0 20.8 8.7e-05 22.1 0.0 9.3 10 1 0 10 10 10 5 Ankyrin repeat Ank_3 PF13606.1 KOO25853.1 - 7.9e-23 78.2 7.5 0.0015 18.6 0.0 8.6 9 0 0 9 9 9 5 Ankyrin repeat FAA_hydrolase_N PF09298.6 KOO25853.1 - 0.63 10.0 7.9 0.16 11.9 0.3 2.9 3 0 0 3 3 3 0 Fumarylacetoacetase N-terminal Abhydrolase_4 PF08386.5 KOO25854.1 - 4e-05 23.4 0.0 7.9e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_6 PF12697.2 KOO25854.1 - 5.7e-05 23.1 0.6 8.8e-05 22.4 0.1 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO25854.1 - 0.033 13.9 0.0 0.043 13.5 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO25854.1 - 0.057 12.9 0.0 0.075 12.5 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Propeptide_C25 PF08126.6 KOO25854.1 - 0.076 11.9 0.0 0.1 11.5 0.0 1.1 1 0 0 1 1 1 0 Propeptide_C25 Vint PF14623.1 KOO25855.1 - 1.3e-10 41.0 0.0 2.9e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 Hint-domain CNH PF00780.17 KOO25856.1 - 1.1e-09 38.1 0.0 1.8e-09 37.4 0.0 1.4 1 1 0 1 1 1 1 CNH domain Apolipoprotein PF01442.13 KOO25856.1 - 0.045 13.2 0.1 0.067 12.6 0.1 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Methyltransf_18 PF12847.2 KOO25858.1 - 9.6e-10 39.0 0.0 4.4e-07 30.4 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.8 KOO25858.1 - 4.8e-08 32.4 0.0 8e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.1 KOO25858.1 - 1.3e-06 28.1 0.0 3.1e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO25858.1 - 3.6e-05 23.7 7.0 0.00028 20.8 1.9 3.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO25858.1 - 4.8e-05 23.7 0.0 0.0002 21.7 0.0 2.1 3 0 0 3 3 2 1 Methyltransferase domain MTS PF05175.9 KOO25858.1 - 6.6e-05 22.3 0.0 0.00012 21.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 KOO25858.1 - 0.00045 20.5 0.0 0.0016 18.8 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO25858.1 - 0.00052 20.4 0.0 0.0021 18.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO25858.1 - 0.00061 19.3 0.0 0.0012 18.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 KOO25858.1 - 0.0034 17.0 0.0 0.0071 16.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.11 KOO25858.1 - 0.21 10.4 0.0 0.31 9.9 0.0 1.2 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase NAD_binding_10 PF13460.1 KOO25859.1 - 1e-07 32.1 2.2 1.7e-07 31.4 1.5 1.3 1 0 0 1 1 1 1 NADH(P)-binding Ank_2 PF12796.2 KOO25860.1 - 2.1e-25 88.8 1.7 1e-10 41.7 0.1 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO25860.1 - 3.8e-16 57.9 0.0 5e-07 29.2 0.1 4.8 4 1 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.1 KOO25860.1 - 1.7e-14 53.5 0.1 3e-08 33.6 0.1 4.0 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO25860.1 - 8e-13 47.2 0.3 5.1e-05 23.1 0.2 4.8 5 0 0 5 5 5 2 Ankyrin repeat FHA PF00498.21 KOO25860.1 - 5e-12 45.7 0.0 1.1e-11 44.6 0.0 1.6 1 0 0 1 1 1 1 FHA domain Ank_4 PF13637.1 KOO25860.1 - 2.9e-10 40.3 0.1 0.00069 20.0 0.1 4.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Spc7 PF08317.6 KOO25860.1 - 0.043 12.4 0.3 0.065 11.8 0.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF883 PF05957.8 KOO25860.1 - 0.051 13.9 0.3 0.16 12.3 0.2 1.8 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) SET PF00856.23 KOO25860.1 - 0.16 12.2 0.0 0.36 11.1 0.0 1.7 1 0 0 1 1 1 0 SET domain Syntaphilin PF15290.1 KOO25860.1 - 0.84 9.0 4.0 1.4 8.3 2.8 1.3 1 0 0 1 1 1 0 Golgi-localised syntaxin-1-binding clamp Galactosyl_T PF01762.16 KOO25861.1 - 0.16 11.5 0.0 0.33 10.5 0.0 1.6 1 1 0 1 1 1 0 Galactosyltransferase DHquinase_II PF01220.14 KOO25862.1 - 0.11 11.7 0.1 0.13 11.5 0.1 1.1 1 0 0 1 1 1 0 Dehydroquinase class II CS PF04969.11 KOO25865.1 - 2.9e-14 53.3 0.0 4.4e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 CS domain Glyco_hydro_2_N PF02837.13 KOO25867.1 - 4.6e-27 94.6 0.0 1.6e-26 92.8 0.0 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.12 KOO25867.1 - 8.2e-19 67.6 0.0 3.8e-16 58.8 0.0 2.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.16 KOO25867.1 - 4.2e-05 23.9 0.0 8.6e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 PAN_4 PF14295.1 KOO25867.1 - 0.16 11.7 18.0 0.16 11.7 10.4 2.6 2 0 0 2 2 2 0 PAN domain EF-hand_5 PF13202.1 KOO25868.1 - 3.4e-08 32.4 2.5 0.0013 18.0 0.2 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO25868.1 - 3.8e-08 33.3 0.7 0.00073 19.6 0.1 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO25868.1 - 3.4e-07 29.5 1.3 0.0027 17.4 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO25868.1 - 1.2e-06 27.3 1.6 0.0048 16.1 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO25868.1 - 3.2e-06 26.6 1.8 8.5e-05 22.0 0.1 2.1 1 1 1 2 2 2 2 EF-hand domain pair Guanylate_cyc PF00211.15 KOO25870.1 - 2.2e-20 72.8 0.0 3.7e-09 36.2 0.0 2.4 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain EF-hand_7 PF13499.1 KOO25870.1 - 4.9e-18 65.0 13.6 1e-06 28.7 0.7 3.8 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO25870.1 - 4.8e-17 59.8 17.3 0.00029 19.9 0.0 5.9 6 0 0 6 6 5 4 EF hand EF-hand_6 PF13405.1 KOO25870.1 - 4.9e-15 53.9 20.3 0.00011 21.8 0.1 6.2 6 0 0 6 6 5 4 EF-hand domain AAA_16 PF13191.1 KOO25870.1 - 2.5e-12 47.1 4.7 1.5e-07 31.6 0.0 3.9 4 0 0 4 4 4 2 AAA ATPase domain EF-hand_5 PF13202.1 KOO25870.1 - 5.6e-12 44.4 14.9 0.0055 16.0 0.1 5.8 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.1 KOO25870.1 - 1.6e-08 33.9 12.9 0.00023 20.7 0.2 5.5 3 2 2 5 5 5 2 EF-hand domain pair EF-hand_4 PF12763.2 KOO25870.1 - 0.0019 17.9 0.6 0.094 12.4 0.1 3.1 3 0 0 3 3 3 1 Cytoskeletal-regulatory complex EF hand DUF2791 PF10923.3 KOO25870.1 - 0.016 13.8 0.0 0.027 13.0 0.0 1.3 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) TPR_17 PF13431.1 KOO25870.1 - 0.021 15.0 0.7 13 6.2 0.0 3.4 3 0 0 3 3 2 0 Tetratricopeptide repeat AAA_22 PF13401.1 KOO25870.1 - 0.025 14.7 0.0 0.1 12.7 0.0 2.1 1 0 0 1 1 1 0 AAA domain EF-hand_10 PF14788.1 KOO25870.1 - 0.034 13.8 0.7 6.2 6.5 0.0 3.5 3 0 0 3 3 3 0 EF hand TPR_16 PF13432.1 KOO25870.1 - 0.095 13.4 0.2 0.095 13.4 0.1 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat NACHT PF05729.7 KOO25870.1 - 0.098 12.3 0.1 0.53 9.9 0.0 2.3 3 0 0 3 3 3 0 NACHT domain EF-hand_6 PF13405.1 KOO25871.1 - 2.5e-12 45.5 0.5 0.02 14.7 0.0 4.0 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.27 KOO25871.1 - 1.7e-11 42.5 1.9 0.002 17.2 0.0 3.9 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.1 KOO25871.1 - 4.4e-09 36.3 0.9 0.00041 20.4 0.3 2.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO25871.1 - 7e-09 35.1 0.2 8.2e-05 22.1 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain pair WW PF00397.21 KOO25871.1 - 8.3e-05 22.3 5.0 0.0011 18.8 0.2 2.8 2 0 0 2 2 2 1 WW domain EF-hand_5 PF13202.1 KOO25871.1 - 0.00049 19.3 16.3 0.0054 16.0 0.0 4.5 5 0 0 5 5 5 2 EF hand SMC_N PF02463.14 KOO25872.1 - 2.1e-25 89.2 0.0 3.3e-25 88.6 0.0 1.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 KOO25872.1 - 9.4e-12 45.6 31.2 9.4e-12 45.6 21.6 5.1 2 2 0 2 2 2 1 AAA domain AAA_21 PF13304.1 KOO25872.1 - 9.4e-05 22.5 0.5 0.0014 18.6 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.1 KOO25872.1 - 0.0012 18.3 0.0 0.003 17.0 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain Clostridium_P47 PF06597.6 KOO25872.1 - 0.064 11.7 0.0 0.11 10.9 0.0 1.3 1 0 0 1 1 1 0 Clostridium P-47 protein AAA_25 PF13481.1 KOO25872.1 - 0.098 12.0 0.0 0.098 12.0 0.0 2.9 4 0 0 4 4 4 0 AAA domain AAA_15 PF13175.1 KOO25872.1 - 0.15 11.0 10.8 1.8 7.5 6.8 2.9 2 1 0 2 2 2 0 AAA ATPase domain DASH_Dam1 PF08653.5 KOO25872.1 - 0.23 11.2 0.6 1.6 8.5 0.2 2.8 2 0 0 2 2 2 0 DASH complex subunit Dam1 DUF4094 PF13334.1 KOO25872.1 - 0.51 10.7 0.0 0.51 10.7 0.0 5.3 6 2 0 6 6 6 0 Domain of unknown function (DUF4094) Reo_sigmaC PF04582.7 KOO25872.1 - 4.1 6.4 6.9 4.6 6.3 1.0 3.3 4 1 0 4 4 4 0 Reovirus sigma C capsid protein CBFD_NFYB_HMF PF00808.18 KOO25873.1 - 1.5e-15 56.9 0.6 1.5e-15 56.9 0.4 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 KOO25873.1 - 4.6e-05 23.4 0.2 8.4e-05 22.6 0.1 1.5 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.11 KOO25873.1 - 0.011 15.5 0.1 0.014 15.2 0.0 1.4 1 1 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit Vps5 PF09325.5 KOO25874.1 - 5.5e-05 22.5 2.7 0.0001 21.6 1.9 1.4 1 0 0 1 1 1 1 Vps5 C terminal like V_ATPase_I PF01496.14 KOO25874.1 - 0.21 9.4 0.3 0.25 9.1 0.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GlcNAc_2-epim PF07221.6 KOO25875.1 - 5.4e-72 242.6 15.8 6.8e-72 242.3 11.0 1.0 1 0 0 1 1 1 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) C5-epim_C PF06662.8 KOO25875.1 - 0.0022 17.2 0.8 0.0053 16.0 0.0 2.0 2 0 0 2 2 2 1 D-glucuronyl C5-epimerase C-terminus Methyltransf_24 PF13578.1 KOO25876.1 - 0.00045 21.0 0.1 0.0016 19.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain GHL13 PF14883.1 KOO25877.1 - 0.046 12.8 0.1 0.067 12.3 0.1 1.1 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 13 DAGK_cat PF00781.19 KOO25878.1 - 2.2e-26 91.7 0.4 4.1e-26 90.9 0.3 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain SKN1 PF03935.10 KOO25879.1 - 5.5e-57 193.0 5.1 1.8e-28 98.9 0.5 3.2 3 0 0 3 3 3 3 Beta-glucan synthesis-associated protein (SKN1) Glyco_hydro_16 PF00722.16 KOO25879.1 - 1.9e-05 24.0 4.7 0.0058 15.9 0.0 3.2 2 1 0 2 2 2 2 Glycosyl hydrolases family 16 cobW PF02492.14 KOO25880.1 - 1.7e-55 187.2 6.9 3.5e-51 173.1 0.8 2.2 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 KOO25880.1 - 5.2e-30 103.0 0.0 7.2e-21 73.7 0.0 2.6 2 0 0 2 2 2 2 Cobalamin synthesis protein cobW C-terminal domain Arch_ATPase PF01637.13 KOO25880.1 - 0.016 14.8 0.0 0.031 13.9 0.0 1.4 1 0 0 1 1 1 0 Archaeal ATPase UPF0079 PF02367.12 KOO25880.1 - 0.056 13.0 0.1 0.15 11.6 0.1 1.7 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_22 PF13401.1 KOO25880.1 - 0.066 13.3 0.1 0.34 11.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.18 KOO25880.1 - 0.094 12.6 0.5 0.43 10.5 0.1 2.3 2 1 0 2 2 2 0 50S ribosome-binding GTPase Glyco_hydro_6 PF01341.12 KOO25881.1 - 3.8e-67 226.8 0.0 6.5e-67 226.0 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 6 EF-hand_1 PF00036.27 KOO25882.1 - 4.9e-21 72.3 2.0 0.00018 20.5 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO25882.1 - 3.9e-19 66.7 1.8 8.3e-05 22.1 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO25882.1 - 1.2e-14 54.1 0.9 6.3e-08 32.6 0.1 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO25882.1 - 1.1e-11 44.1 2.7 0.015 14.8 0.0 3.5 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO25882.1 - 8.4e-09 34.3 8.0 0.00055 19.1 0.1 4.3 4 0 0 4 4 4 2 EF hand HPP PF04982.8 KOO25882.1 - 0.05 13.4 5.1 0.085 12.7 3.5 1.4 1 0 0 1 1 1 0 HPP family Syntaxin-18_N PF10496.4 KOO25883.1 - 1.5e-08 34.3 0.0 3.5e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.14 KOO25883.1 - 0.0001 21.8 2.0 0.00015 21.3 0.5 2.0 2 0 0 2 2 2 1 SNARE domain Tropomyosin_1 PF12718.2 KOO25883.1 - 0.0047 16.7 6.2 0.0096 15.7 4.3 1.5 1 0 0 1 1 1 1 Tropomyosin like AAA_32 PF13654.1 KOO25883.1 - 0.13 10.9 4.0 0.12 11.0 1.9 1.5 2 0 0 2 2 2 0 AAA domain DUF1068 PF06364.7 KOO25883.1 - 0.21 11.2 3.0 0.42 10.1 2.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1068) Atg14 PF10186.4 KOO25883.1 - 0.47 9.3 3.6 1.1 8.1 2.5 1.6 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 OmpH PF03938.9 KOO25883.1 - 0.54 10.1 10.5 2.6 7.9 0.0 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF4404 PF14357.1 KOO25883.1 - 9.3 6.7 13.3 7 7.1 3.5 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF4404) Acyl-CoA_dh_1 PF00441.19 KOO25884.1 - 2.7e-51 173.6 7.6 5.4e-51 172.6 5.2 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 KOO25884.1 - 1e-39 135.5 1.5 2.9e-39 134.1 0.1 2.4 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.6 KOO25884.1 - 2.6e-24 85.9 7.0 5e-24 85.0 4.8 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 KOO25884.1 - 3.4e-21 74.4 1.7 7e-21 73.4 1.2 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain HpaB_N PF11794.3 KOO25884.1 - 0.00018 21.0 0.1 0.0028 17.0 0.0 2.1 2 0 0 2 2 2 1 4-hydroxyphenylacetate 3-hydroxylase N terminal DUF743 PF05332.6 KOO25884.1 - 0.046 13.6 0.3 0.09 12.7 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF743) PLU-1 PF08429.6 KOO25885.1 - 1.5e-05 24.0 0.0 0.00028 19.8 0.0 2.0 2 0 0 2 2 2 2 PLU-1-like protein DUF2360 PF10152.4 KOO25886.1 - 0.056 13.7 3.2 0.12 12.6 2.2 1.5 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) PLU-1 PF08429.6 KOO25887.1 - 2.7e-36 125.1 15.7 2.5e-12 46.3 0.0 4.5 2 1 3 5 5 5 4 PLU-1-like protein PHD PF00628.24 KOO25887.1 - 1.3e-09 37.5 3.8 3e-09 36.4 2.6 1.5 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.1 KOO25887.1 - 0.018 15.2 0.6 0.072 13.2 0.0 2.2 2 0 0 2 2 2 0 PHD-like zinc-binding domain C1_1 PF00130.17 KOO25887.1 - 0.12 12.1 1.2 0.27 11.0 0.9 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-ZPR1 PF03367.8 KOO25887.1 - 0.12 11.5 0.1 0.41 9.7 0.0 1.9 1 0 0 1 1 1 0 ZPR1 zinc-finger domain TilS PF09179.6 KOO25887.1 - 3.3 7.8 8.3 1.6 8.8 0.1 3.7 3 1 1 4 4 4 0 TilS substrate binding domain HSP90 PF00183.13 KOO25888.1 - 8.4e-177 588.7 31.8 1.1e-176 588.4 22.0 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c_3 PF13589.1 KOO25888.1 - 2e-10 40.4 0.5 4.8e-10 39.2 0.3 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 KOO25888.1 - 2e-06 27.5 0.1 3.7e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase AAA_22 PF13401.1 KOO25888.1 - 0.07 13.2 0.0 0.19 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain zf-RanBP PF00641.13 KOO25889.1 - 9.3e-07 27.8 5.0 2.5e-06 26.4 3.5 1.8 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Methyltransf_16 PF10294.4 KOO25891.1 - 6.9e-19 67.9 0.0 1.1e-18 67.2 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 KOO25891.1 - 0.00032 21.2 0.0 0.0009 19.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO25891.1 - 0.025 14.1 0.0 0.038 13.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain EF-hand_8 PF13833.1 KOO25892.1 - 0.00073 19.1 0.0 0.0017 17.9 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO25892.1 - 0.064 12.5 0.0 0.16 11.3 0.0 1.7 1 0 0 1 1 1 0 EF hand HTH_3 PF01381.17 KOO25893.1 - 2.2e-12 46.6 0.9 6.5e-12 45.1 0.1 1.9 2 0 0 2 2 2 1 Helix-turn-helix HTH_19 PF12844.2 KOO25893.1 - 8.4e-08 32.1 0.2 1.5e-07 31.3 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.1 KOO25893.1 - 8.9e-06 25.8 0.0 1.5e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MBF1 PF08523.5 KOO25893.1 - 0.0015 18.4 2.2 0.85 9.6 0.0 3.0 3 0 0 3 3 3 2 Multiprotein bridging factor 1 HTH_25 PF13413.1 KOO25893.1 - 0.013 15.1 0.0 0.024 14.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain eIF-3c_N PF05470.7 KOO25893.1 - 0.018 13.1 0.0 0.018 13.1 0.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DUF3071 PF11268.3 KOO25893.1 - 0.048 13.4 0.1 0.06 13.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) Ribosomal_L29 PF00831.18 KOO25893.1 - 0.11 12.2 3.2 0.23 11.1 1.7 1.9 1 1 1 2 2 2 0 Ribosomal L29 protein HTH_37 PF13744.1 KOO25893.1 - 0.15 11.8 1.1 0.23 11.2 0.8 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain CASP_C PF08172.7 KOO25893.1 - 0.52 9.2 3.7 0.27 10.2 0.2 1.9 1 1 1 2 2 2 0 CASP C terminal PLU-1 PF08429.6 KOO25894.1 - 2.6e-13 49.5 9.0 2.4e-11 43.1 2.7 2.3 2 0 0 2 2 2 2 PLU-1-like protein PHD PF00628.24 KOO25894.1 - 4.4e-08 32.7 8.7 7.7e-08 31.9 6.1 1.4 1 0 0 1 1 1 1 PHD-finger zf-PHD-like PF15446.1 KOO25894.1 - 0.0016 17.8 3.4 0.058 12.6 0.3 2.2 1 1 1 2 2 2 2 PHD/FYVE-zinc-finger like domain DUF2277 PF10041.4 KOO25894.1 - 0.003 17.4 0.1 0.034 14.1 0.1 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2277) PsaA_PsaB PF00223.14 KOO25894.1 - 0.18 9.8 0.0 0.24 9.4 0.0 1.1 1 0 0 1 1 1 0 Photosystem I psaA/psaB protein PHD_2 PF13831.1 KOO25894.1 - 0.45 9.8 4.9 1.8 7.9 3.4 2.0 1 1 0 1 1 1 0 PHD-finger C1_1 PF00130.17 KOO25894.1 - 1.8 8.3 6.6 0.15 11.8 0.9 1.9 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) ArfGap PF01412.13 KOO25896.1 - 4.4e-32 110.2 0.0 8.9e-32 109.3 0.0 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf C2 PF00168.25 KOO25896.1 - 6.8e-18 64.2 0.0 1.7e-17 62.9 0.0 1.7 1 0 0 1 1 1 1 C2 domain IncA PF04156.9 KOO25896.1 - 0.00012 21.6 9.8 0.00022 20.8 6.8 1.3 1 0 0 1 1 1 1 IncA protein AAA_27 PF13514.1 KOO25896.1 - 0.0035 15.1 12.5 0.0051 14.5 8.7 1.2 1 0 0 1 1 1 1 AAA domain DUF4201 PF13870.1 KOO25896.1 - 0.004 16.5 0.8 0.004 16.5 0.5 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4201) Bacillus_HBL PF05791.6 KOO25896.1 - 0.014 14.7 1.5 0.031 13.6 0.1 1.9 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Spc7 PF08317.6 KOO25896.1 - 0.032 12.9 5.5 0.063 11.9 3.7 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein HAP1_N PF04849.8 KOO25896.1 - 0.042 12.7 5.8 0.13 11.1 4.0 1.7 1 1 0 1 1 1 0 HAP1 N-terminal conserved region Aminotran_3 PF00202.16 KOO25896.1 - 0.059 12.2 0.0 0.11 11.3 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-III Flagellin_C PF00700.16 KOO25896.1 - 0.11 12.7 0.1 0.24 11.5 0.1 1.6 1 0 0 1 1 1 0 Bacterial flagellin C-terminal helical region TPR_MLP1_2 PF07926.7 KOO25896.1 - 0.11 12.2 9.8 0.33 10.7 6.5 2.0 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein TBPIP PF07106.8 KOO25896.1 - 0.29 10.6 5.3 0.35 10.4 1.1 2.1 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) COG2 PF06148.6 KOO25896.1 - 0.3 10.9 1.3 0.6 9.9 0.7 1.6 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.6 KOO25896.1 - 0.31 10.8 2.7 0.27 11.1 0.6 1.8 2 0 0 2 2 1 0 Vps51/Vps67 AAA_13 PF13166.1 KOO25896.1 - 0.31 9.4 7.8 0.42 9.0 5.4 1.1 1 0 0 1 1 1 0 AAA domain TMF_DNA_bd PF12329.3 KOO25896.1 - 0.91 9.3 11.4 4.6 7.1 3.9 2.7 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding CDC37_N PF03234.9 KOO25896.1 - 1.2 9.4 5.9 2.1 8.6 4.1 1.3 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding Sugarporin_N PF11471.3 KOO25896.1 - 1.7 8.3 7.5 1.7 8.3 1.1 2.7 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension SlyX PF04102.7 KOO25896.1 - 2.1 8.8 5.3 22 5.4 0.2 3.3 2 1 0 2 2 2 0 SlyX Atg14 PF10186.4 KOO25896.1 - 4.2 6.2 13.3 0.6 9.0 4.5 2.0 1 1 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 SPX PF03105.14 KOO25896.1 - 5.7 6.6 8.5 18 4.9 4.7 2.2 1 1 0 1 1 1 0 SPX domain DUF4200 PF13863.1 KOO25896.1 - 8.4 6.3 13.6 3 7.8 6.5 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) LRR_6 PF13516.1 KOO25897.1 - 9e-10 37.6 3.7 2.8 8.3 0.3 6.9 6 1 0 6 6 6 3 Leucine Rich repeat LRR_1 PF00560.28 KOO25897.1 - 0.00026 20.5 0.2 1.7 8.9 0.0 5.0 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_4 PF12799.2 KOO25897.1 - 0.0077 15.8 0.5 4.4 7.0 0.0 3.7 4 0 0 4 4 4 1 Leucine Rich repeats (2 copies) DUF2839 PF10999.3 KOO25897.1 - 0.15 12.1 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2839) LRR_7 PF13504.1 KOO25897.1 - 0.15 12.3 4.4 7.8 7.1 0.1 4.5 4 0 0 4 4 4 0 Leucine rich repeat LRR_8 PF13855.1 KOO25897.1 - 0.99 9.2 3.6 14 5.5 0.2 3.4 4 1 0 4 4 4 0 Leucine rich repeat STT3 PF02516.9 KOO25898.1 - 5.3e-62 210.3 16.0 3.7e-59 200.9 10.9 2.0 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit IF3_N PF05198.11 KOO25899.1 - 0.041 13.8 0.0 0.069 13.0 0.0 1.3 1 0 0 1 1 1 0 Translation initiation factor IF-3, N-terminal domain Glyco_transf_29 PF00777.13 KOO25901.1 - 3.1e-30 105.2 0.0 6e-30 104.2 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Cir_N PF10197.4 KOO25902.1 - 0.027 14.4 2.0 0.027 14.4 1.4 2.2 2 0 0 2 2 2 0 N-terminal domain of CBF1 interacting co-repressor CIR RRM_1 PF00076.17 KOO25903.1 - 1.2e-16 60.0 0.0 0.00062 19.3 0.0 5.2 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO25903.1 - 4.9e-14 51.9 0.0 6.8e-07 29.0 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO25903.1 - 1e-13 51.0 0.0 0.0004 20.2 0.0 3.6 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) SBBP PF06739.6 KOO25904.1 - 1.3e-22 79.2 52.7 0.00069 19.3 1.2 8.1 8 0 0 8 8 8 6 Beta-propeller repeat A2M PF00207.17 KOO25904.1 - 0.02 14.4 1.2 50 3.5 0.0 4.2 4 0 0 4 4 4 0 Alpha-2-macroglobulin family OCIA PF07051.6 KOO25904.1 - 7.8 5.9 24.7 4 6.8 0.1 6.7 7 0 0 7 7 7 0 Ovarian carcinoma immunoreactive antigen (OCIA) Choline_transpo PF04515.7 KOO25905.1 - 4e-29 101.4 12.3 3.7e-21 75.2 1.5 3.5 2 1 1 3 3 3 3 Plasma-membrane choline transporter adh_short PF00106.20 KOO25905.1 - 6.5e-09 35.9 2.1 7.7e-09 35.6 0.1 2.2 2 0 0 2 2 2 1 short chain dehydrogenase EF-hand_1 PF00036.27 KOO25906.1 - 5.8e-16 56.5 0.1 2.8e-06 26.2 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 KOO25906.1 - 2.4e-15 54.9 0.0 0.00019 21.0 0.0 3.7 3 0 0 3 3 3 3 EF-hand domain Thioredoxin PF00085.15 KOO25906.1 - 5.7e-15 54.8 0.0 1.2e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin EF-hand_5 PF13202.1 KOO25906.1 - 1.2e-13 49.7 0.5 0.0011 18.2 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.1 KOO25906.1 - 3.2e-12 46.4 0.1 0.0037 17.3 0.0 3.3 2 1 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO25906.1 - 2.2e-10 39.9 4.5 0.00023 20.7 0.0 3.8 4 0 0 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO25906.1 - 0.011 15.8 0.0 0.84 9.6 0.0 2.9 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO25906.1 - 0.081 12.6 0.3 9.9 5.9 0.0 2.7 3 0 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand G8 PF10162.4 KOO25907.1 - 6.4e-18 64.7 0.0 1.6e-17 63.4 0.0 1.7 2 0 0 2 2 2 1 G8 domain Amnionless PF14828.1 KOO25907.1 - 0.0078 14.7 0.0 0.012 14.1 0.0 1.2 1 0 0 1 1 1 1 Amnionless Beta_helix PF13229.1 KOO25907.1 - 0.031 14.0 5.9 0.31 10.7 2.1 2.9 2 1 0 2 2 2 0 Right handed beta helix region Nucleotid_trans PF03407.11 KOO25908.1 - 9e-36 123.6 0.0 1.2e-35 123.1 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase RmlD_sub_bind PF04321.12 KOO25909.1 - 5.7e-35 120.5 0.0 8.4e-35 120.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.16 KOO25909.1 - 5.2e-22 78.4 0.0 8e-22 77.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF218 PF02698.12 KOO25909.1 - 1.3e-12 47.4 1.0 3.2e-12 46.2 0.3 1.9 2 0 0 2 2 2 1 DUF218 domain 3Beta_HSD PF01073.14 KOO25909.1 - 4.9e-07 28.7 0.0 7.2e-07 28.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 KOO25909.1 - 8e-07 28.2 0.1 0.015 14.2 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.10 KOO25909.1 - 6.1e-05 22.0 0.1 0.00021 20.3 0.1 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.20 KOO25909.1 - 0.00015 21.7 1.2 0.00049 20.0 0.8 1.9 1 0 0 1 1 1 1 short chain dehydrogenase DapB_N PF01113.15 KOO25909.1 - 0.0041 17.0 0.1 0.0073 16.2 0.1 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus NAD_binding_10 PF13460.1 KOO25909.1 - 0.01 15.8 0.2 0.023 14.7 0.1 1.6 1 0 0 1 1 1 0 NADH(P)-binding Semialdhyde_dh PF01118.19 KOO25909.1 - 0.026 14.8 0.1 0.058 13.6 0.1 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain UQ_con PF00179.21 KOO25910.1 - 1.7e-50 170.0 0.0 1.9e-50 169.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KOO25910.1 - 7e-06 25.8 0.0 7.9e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 KOO25910.1 - 6.2e-05 22.8 0.0 7.3e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 KOO25910.1 - 0.034 13.8 0.0 0.051 13.2 0.0 1.3 1 0 0 1 1 1 0 UEV domain Hydrolase_3 PF08282.7 KOO25912.1 - 3e-44 151.5 0.0 4.2e-44 151.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.8 KOO25912.1 - 2.2e-09 36.9 0.0 4.1e-06 26.2 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase HAD PF12710.2 KOO25912.1 - 4.2e-05 23.8 0.0 0.00047 20.3 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOO25912.1 - 0.00059 20.3 0.4 0.05 14.0 0.2 2.4 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase DNA_photolyase PF00875.13 KOO25912.1 - 0.04 13.6 0.0 0.17 11.6 0.0 1.9 2 0 0 2 2 2 0 DNA photolyase HTH_31 PF13560.1 KOO25912.1 - 0.061 13.5 0.3 5.9 7.1 0.0 2.9 2 0 0 2 2 2 0 Helix-turn-helix domain Myb_DNA-binding PF00249.26 KOO25913.1 - 0.041 13.9 0.3 0.29 11.2 0.2 2.3 1 1 0 1 1 1 0 Myb-like DNA-binding domain Gram_pos_anchor PF00746.16 KOO25914.1 - 0.87 9.4 7.1 0.71 9.7 3.9 1.5 1 1 0 1 1 1 0 Gram positive anchor Gla PF00594.15 KOO25916.1 - 0.02 14.5 7.9 12 5.6 0.1 4.2 4 0 0 4 4 4 0 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain Shisa PF13908.1 KOO25917.1 - 0.00016 21.8 0.0 0.00016 21.8 0.0 2.6 3 0 0 3 3 3 1 Wnt and FGF inhibitory regulator FAM163 PF15069.1 KOO25917.1 - 0.047 14.2 12.6 0.056 14.0 6.2 2.7 1 1 2 3 3 3 0 FAM163 family AhpC-TSA PF00578.16 KOO25917.1 - 0.12 12.0 0.1 0.5 10.0 0.0 2.0 2 0 0 2 2 2 0 AhpC/TSA family P12 PF12669.2 KOO25917.1 - 0.17 12.1 5.2 0.34 11.1 3.6 1.4 1 0 0 1 1 1 0 Virus attachment protein p12 family PA26 PF04636.8 KOO25917.1 - 0.73 8.4 9.1 0.059 12.0 1.7 2.1 1 1 1 2 2 2 0 PA26 p53-induced protein (sestrin) DUF106 PF01956.11 KOO25917.1 - 3 7.3 4.6 12 5.4 1.0 2.3 2 0 0 2 2 2 0 Integral membrane protein DUF106 IncA PF04156.9 KOO25917.1 - 4.3 6.8 21.1 2.7e+03 -2.3 14.6 2.3 1 1 0 1 1 1 0 IncA protein Prominin PF05478.6 KOO25917.1 - 5.7 4.3 7.6 0.34 8.3 0.9 1.9 2 0 0 2 2 2 0 Prominin DUF1295 PF06966.7 KOO25919.1 - 2.4e-39 135.0 1.8 4.3e-39 134.1 1.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) DUF2615 PF11027.3 KOO25919.1 - 6.5e-07 29.2 1.4 1.4e-06 28.1 1.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2615) ICMT PF04140.9 KOO25919.1 - 0.00016 21.8 1.9 0.00026 21.1 0.0 2.3 3 0 0 3 3 3 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Steroid_dh PF02544.11 KOO25919.1 - 0.043 13.5 0.0 0.12 12.1 0.0 1.7 2 0 0 2 2 2 0 3-oxo-5-alpha-steroid 4-dehydrogenase Crystall PF00030.14 KOO25919.1 - 0.14 12.1 0.0 0.35 10.7 0.0 1.7 2 0 0 2 2 2 0 Beta/Gamma crystallin PEMT PF04191.8 KOO25919.1 - 0.16 12.0 1.6 0.79 9.8 0.0 2.8 3 0 0 3 3 3 0 Phospholipid methyltransferase 2-Hacid_dh_C PF02826.14 KOO25920.1 - 8e-34 116.3 0.0 3.8e-24 84.8 0.0 2.2 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain EF-hand_1 PF00036.27 KOO25921.1 - 3.5e-26 88.4 1.5 1.2e-05 24.2 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO25921.1 - 3.8e-23 79.2 0.6 9.1e-05 22.0 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO25921.1 - 5.5e-22 77.6 4.1 5.2e-07 29.6 0.0 3.5 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO25921.1 - 1.5e-20 71.4 3.6 0.00073 18.7 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO25921.1 - 2.3e-18 65.5 2.0 0.00019 20.9 0.1 4.2 4 0 0 4 4 4 4 EF-hand domain pair Epimerase PF01370.16 KOO25921.1 - 4.4e-06 26.3 0.0 7.1e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family SPARC_Ca_bdg PF10591.4 KOO25921.1 - 0.0032 17.4 0.3 13 5.8 0.0 3.7 2 1 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region Polysacc_deac_1 PF01522.16 KOO25922.1 - 3.8e-09 36.2 0.0 9.9e-09 34.8 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide deacetylase EF-hand_7 PF13499.1 KOO25923.1 - 1.7e-10 40.8 0.1 3.3e-10 39.9 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO25923.1 - 1e-08 34.3 0.2 8.5e-07 28.3 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 KOO25923.1 - 6e-08 31.4 0.0 1.2e-06 27.4 0.0 2.3 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.1 KOO25923.1 - 5.2e-06 25.5 0.0 1.1e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 KOO25923.1 - 0.019 14.5 0.0 0.062 12.9 0.0 1.8 2 0 0 2 2 2 0 EF-hand domain pair GreA_GreB_N PF03449.10 KOO25923.1 - 0.068 13.2 0.1 0.13 12.3 0.1 1.4 1 0 0 1 1 1 0 Transcription elongation factor, N-terminal His_Phos_1 PF00300.17 KOO25924.1 - 1.7e-38 132.2 0.0 3.5e-38 131.1 0.0 1.5 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) TPR_10 PF13374.1 KOO25925.1 - 2.8e-43 144.6 16.0 8.9e-14 50.8 0.3 5.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_12 PF13424.1 KOO25925.1 - 3.7e-35 119.6 11.7 6.3e-20 70.8 1.1 3.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO25925.1 - 3.4e-14 51.7 3.4 0.0011 18.4 0.0 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO25925.1 - 9.7e-13 46.8 12.9 0.00093 18.8 0.3 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.1 KOO25925.1 - 1.2e-11 44.0 7.3 7.5e-09 35.1 0.6 4.4 3 1 1 4 4 4 3 TPR repeat TPR_8 PF13181.1 KOO25925.1 - 8.4e-10 37.7 3.0 0.028 14.2 0.0 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO25925.1 - 2e-08 33.5 17.0 0.0085 15.9 0.1 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO25925.1 - 4.2e-07 30.4 24.7 8e-05 23.1 3.3 6.5 5 1 2 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO25925.1 - 2e-06 27.5 0.4 1.6 9.0 0.0 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat DUF904 PF06005.7 KOO25925.1 - 0.068 13.4 0.1 0.068 13.4 0.0 6.6 7 0 0 7 7 7 0 Protein of unknown function (DUF904) TPR_14 PF13428.1 KOO25925.1 - 0.093 13.4 0.1 0.093 13.4 0.1 6.7 6 1 1 7 7 4 0 Tetratricopeptide repeat Rab5-bind PF09311.6 KOO25925.1 - 0.096 12.5 36.6 0.19 11.6 0.1 6.8 6 1 1 7 7 7 0 Rabaptin-like protein TPR_6 PF13174.1 KOO25925.1 - 7.7 7.2 8.1 97 3.7 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat UDPGP PF01704.13 KOO25926.1 - 1.5e-06 27.0 0.0 1.2e-05 23.9 0.0 1.9 1 1 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase RAB3GAP2_C PF14656.1 KOO25928.1 - 0.058 11.5 0.1 0.058 11.5 0.1 1.0 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus SBBP PF06739.6 KOO25929.1 - 1.2e-12 47.3 52.0 0.0014 18.3 0.3 9.3 9 0 0 9 9 9 8 Beta-propeller repeat MMR_HSR1 PF01926.18 KOO25930.1 - 1.6e-06 28.0 0.0 3.9e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Abhydrolase_6 PF12697.2 KOO25930.1 - 0.00034 20.5 0.2 0.0081 16.0 0.1 2.8 1 1 2 3 3 3 1 Alpha/beta hydrolase family Dynamin_N PF00350.18 KOO25930.1 - 0.00055 19.7 0.0 0.031 14.0 0.0 2.4 2 0 0 2 2 2 1 Dynamin family AIG1 PF04548.11 KOO25930.1 - 0.0015 17.6 0.2 0.0097 15.0 0.1 2.1 1 1 0 1 1 1 1 AIG1 family DUF258 PF03193.11 KOO25930.1 - 0.0017 17.5 0.0 0.005 16.0 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 KOO25930.1 - 0.0019 18.5 0.0 0.0038 17.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter GTP_EFTU PF00009.22 KOO25930.1 - 0.0043 16.5 0.0 0.015 14.7 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_17 PF13207.1 KOO25930.1 - 0.017 15.9 0.0 0.085 13.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.1 KOO25930.1 - 0.019 15.1 0.1 0.049 13.7 0.1 2.0 1 1 0 1 1 1 0 AAA domain T2SE PF00437.15 KOO25930.1 - 0.024 13.5 0.0 0.04 12.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.1 KOO25930.1 - 0.029 14.3 0.1 0.086 12.8 0.0 2.0 1 1 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.1 KOO25930.1 - 0.037 13.5 0.0 0.072 12.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain MobB PF03205.9 KOO25930.1 - 0.064 12.9 0.0 1.3 8.6 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_28 PF13521.1 KOO25930.1 - 0.074 13.0 0.0 0.22 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 KOO25930.1 - 0.13 12.7 0.0 0.29 11.6 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein Vps5 PF09325.5 KOO25931.1 - 2.7e-27 95.5 3.0 4.7e-27 94.7 2.1 1.3 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.19 KOO25931.1 - 4e-24 84.5 0.3 6.4e-24 83.9 0.2 1.3 1 0 0 1 1 1 1 PX domain BAR PF03114.13 KOO25931.1 - 1.4e-07 31.2 2.0 1.4e-07 31.2 1.4 2.2 2 0 0 2 2 2 1 BAR domain BAR_3_WASP_bdg PF10456.4 KOO25931.1 - 0.0021 17.3 1.7 0.0093 15.2 0.2 2.2 1 1 1 2 2 2 1 WASP-binding domain of Sorting nexin protein FAM92 PF06730.6 KOO25931.1 - 0.036 13.4 1.9 0.091 12.0 1.3 1.7 1 1 0 1 1 1 0 FAM92 protein EF-hand_7 PF13499.1 KOO25932.1 - 3.2e-12 46.4 3.0 3.2e-08 33.5 0.5 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO25932.1 - 1.3e-11 42.9 2.3 0.0012 17.9 0.3 3.9 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 KOO25932.1 - 1.9e-10 39.7 6.0 0.024 14.5 0.7 3.9 3 1 1 4 4 4 3 EF-hand domain EF-hand_5 PF13202.1 KOO25932.1 - 2e-08 33.1 7.4 0.0033 16.6 0.7 4.0 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO25932.1 - 6.3e-08 32.1 2.2 3.8e-06 26.4 0.5 2.8 2 1 0 2 2 2 1 EF-hand domain pair Glyco_hydro_3 PF00933.16 KOO25934.1 - 7.7e-59 199.1 0.0 1e-58 198.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 KOO25934.1 - 7.4e-46 156.4 0.0 2e-45 155.0 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 KOO25934.1 - 2.4e-13 49.7 0.0 4.7e-13 48.8 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain PAN_1 PF00024.21 KOO25934.1 - 2.3e-07 30.4 5.2 4.3e-07 29.5 3.6 1.5 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.1 KOO25934.1 - 0.0087 15.7 4.3 0.019 14.6 3.0 1.6 1 0 0 1 1 1 1 PAN domain EF-hand_7 PF13499.1 KOO25935.1 - 2.8e-06 27.3 0.3 5.3e-06 26.4 0.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO25935.1 - 0.0014 17.8 0.3 0.0074 15.5 0.0 2.4 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.1 KOO25935.1 - 0.0014 17.9 0.1 0.0049 16.1 0.0 2.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO25935.1 - 0.0024 17.6 0.1 0.043 13.6 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain Peptidase_S10 PF00450.17 KOO25936.1 - 6.5e-88 295.6 0.0 9.4e-88 295.1 0.0 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase TPR_16 PF13432.1 KOO25937.1 - 3.8e-45 151.6 88.5 5.9e-08 33.1 0.8 10.9 3 2 12 15 15 15 15 Tetratricopeptide repeat TPR_14 PF13428.1 KOO25937.1 - 1.2e-39 131.1 83.9 0.00053 20.3 1.0 18.2 2 2 17 19 19 19 15 Tetratricopeptide repeat TPR_11 PF13414.1 KOO25937.1 - 1.4e-39 133.5 35.9 2.1e-06 27.2 0.0 10.0 8 2 2 10 10 10 7 TPR repeat TPR_19 PF14559.1 KOO25937.1 - 2e-37 127.3 31.9 0.00026 21.2 0.1 10.2 7 2 3 11 11 11 9 Tetratricopeptide repeat TPR_2 PF07719.12 KOO25937.1 - 6.1e-36 119.4 51.8 0.032 14.1 0.0 18.0 17 2 2 19 19 19 12 Tetratricopeptide repeat TPR_17 PF13431.1 KOO25937.1 - 1.1e-28 96.9 13.7 0.022 14.9 0.0 13.9 16 0 0 16 16 15 7 Tetratricopeptide repeat TPR_12 PF13424.1 KOO25937.1 - 2.5e-24 85.0 40.7 6e-05 22.8 0.0 11.4 4 2 9 13 13 13 8 Tetratricopeptide repeat TPR_1 PF00515.23 KOO25937.1 - 2.3e-20 71.2 2.2 0.023 14.3 0.0 12.1 14 0 0 14 14 13 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO25937.1 - 2.2e-14 52.0 0.6 4.1 7.4 0.1 12.8 16 1 1 17 17 15 1 Tetratricopeptide repeat TPR_15 PF13429.1 KOO25937.1 - 4.3e-12 45.6 23.6 0.0068 15.5 0.0 6.8 1 1 5 7 7 7 4 Tetratricopeptide repeat Suf PF05843.9 KOO25937.1 - 1e-09 38.5 0.0 0.063 13.0 0.0 5.0 3 2 1 5 5 5 2 Suppressor of forked protein (Suf) TPR_6 PF13174.1 KOO25937.1 - 1.4e-09 37.7 35.6 1.1 9.8 0.0 14.5 16 1 1 17 17 16 1 Tetratricopeptide repeat Coatomer_E PF04733.9 KOO25937.1 - 1.5e-08 34.2 0.0 0.041 13.0 0.0 4.5 4 2 1 5 5 5 2 Coatomer epsilon subunit TPR_9 PF13371.1 KOO25937.1 - 1.1e-07 31.6 58.1 0.00015 21.5 0.3 9.7 4 3 6 10 10 10 4 Tetratricopeptide repeat TPR_7 PF13176.1 KOO25937.1 - 0.00012 21.5 24.9 3.9 7.4 0.1 11.8 14 0 0 14 14 14 1 Tetratricopeptide repeat NARP1 PF12569.3 KOO25937.1 - 0.0022 16.8 1.3 2 7.1 0.0 4.7 3 2 1 5 5 5 1 NMDA receptor-regulated protein 1 DUF3808 PF10300.4 KOO25937.1 - 0.03 12.9 1.6 2.2 6.7 0.0 3.6 5 0 0 5 5 5 0 Protein of unknown function (DUF3808) FAT PF02259.18 KOO25937.1 - 0.039 12.9 4.3 0.36 9.7 0.0 3.6 3 1 1 4 4 4 0 FAT domain DUF2379 PF09543.5 KOO25937.1 - 0.25 11.3 0.0 0.25 11.3 0.0 3.9 4 1 0 4 4 4 0 Protein of unknown function (DUF2379) Methyltransf_21 PF05050.7 KOO25939.1 - 4.2e-14 52.8 0.0 5e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase FkbM domain UPF0079 PF02367.12 KOO25939.1 - 0.049 13.2 0.0 0.067 12.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Phage_integrase PF00589.17 KOO25940.1 - 0.0037 16.9 0.0 0.0049 16.5 0.0 1.1 1 0 0 1 1 1 1 Phage integrase family Sugar_tr PF00083.19 KOO25941.1 - 6.7e-07 28.2 3.4 7.6e-07 28.0 2.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOO25941.1 - 3e-06 26.1 3.4 3.7e-06 25.8 2.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily EF-hand_5 PF13202.1 KOO25941.1 - 0.00018 20.7 4.8 2.8 7.4 0.0 4.3 3 1 1 4 4 4 3 EF hand EF-hand_1 PF00036.27 KOO25941.1 - 0.0026 16.9 6.7 1.2 8.6 0.1 4.7 2 1 3 5 5 5 2 EF hand MFS_2 PF13347.1 KOO25941.1 - 0.021 13.2 0.4 0.026 12.9 0.3 1.1 1 0 0 1 1 1 0 MFS/sugar transport protein EF-hand_7 PF13499.1 KOO25941.1 - 0.36 11.0 5.3 1.2 9.3 1.4 3.1 1 1 1 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.1 KOO25941.1 - 0.87 9.6 6.0 22 5.2 0.0 4.4 3 2 2 5 5 5 0 EF-hand domain PAE PF03283.8 KOO25942.1 - 5.9e-15 54.7 0.0 8.5e-15 54.2 0.0 1.2 1 0 0 1 1 1 1 Pectinacetylesterase Sugar_tr PF00083.19 KOO25943.1 - 1.7e-11 43.3 26.9 1e-05 24.3 4.5 2.7 2 1 0 2 2 2 2 Sugar (and other) transporter PAP_fibrillin PF04755.7 KOO25944.1 - 8.3e-15 55.0 0.0 1.6e-09 37.7 0.0 2.2 2 0 0 2 2 2 2 PAP_fibrillin DAO PF01266.19 KOO25945.1 - 2.4e-30 105.6 0.5 3.1e-30 105.3 0.3 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.17 KOO25945.1 - 0.00037 19.4 2.6 0.12 11.2 1.5 2.4 2 1 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_3 PF13738.1 KOO25945.1 - 0.00057 20.0 0.3 0.0082 16.2 0.2 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 KOO25945.1 - 0.00067 19.6 0.3 0.0021 18.0 0.2 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 KOO25945.1 - 0.0016 18.3 2.1 0.14 12.0 0.2 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.15 KOO25945.1 - 0.0032 17.5 0.2 0.0061 16.6 0.1 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ThiF PF00899.16 KOO25945.1 - 0.0034 17.1 0.6 0.0086 15.9 0.4 1.6 1 0 0 1 1 1 1 ThiF family Thi4 PF01946.12 KOO25945.1 - 0.0074 15.4 0.4 0.015 14.4 0.3 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.1 KOO25945.1 - 0.018 14.7 1.3 3.1 7.5 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.14 KOO25945.1 - 0.052 12.5 0.5 0.079 11.9 0.4 1.2 1 0 0 1 1 1 0 FAD binding domain FAD_binding_2 PF00890.19 KOO25945.1 - 0.079 11.7 2.2 0.073 11.9 0.5 1.7 2 0 0 2 2 2 0 FAD binding domain Lycopene_cycl PF05834.7 KOO25945.1 - 0.28 10.0 1.0 3.4 6.4 0.0 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein Sugar_tr PF00083.19 KOO25946.1 - 1.2e-32 113.1 16.2 8.2e-19 67.5 3.5 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 KOO25946.1 - 2.3e-24 85.7 42.0 7.6e-22 77.4 18.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KOO25946.1 - 6.5e-06 24.7 8.6 0.0019 16.7 2.0 3.3 1 1 2 3 3 3 3 MFS/sugar transport protein YtxH PF12732.2 KOO25946.1 - 0.039 14.3 0.4 0.039 14.3 0.2 2.1 2 0 0 2 2 2 0 YtxH-like protein ADH_N PF08240.7 KOO25947.1 - 2.3e-10 40.1 0.2 4.4e-10 39.2 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DUF2823 PF11034.3 KOO25947.1 - 0.2 11.8 2.8 0.12 12.5 0.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2823) Filamin PF00630.14 KOO25948.1 - 8e-14 52.0 0.0 4.4e-12 46.4 0.0 2.7 2 0 0 2 2 2 1 Filamin/ABP280 repeat Neurexophilin PF06312.7 KOO25948.1 - 0.012 14.8 0.0 0.025 13.8 0.0 1.5 1 0 0 1 1 1 0 Neurexophilin MMR_HSR1 PF01926.18 KOO25949.1 - 1.6e-45 153.8 0.1 8.7e-24 83.7 0.0 2.2 2 0 0 2 2 2 2 50S ribosome-binding GTPase KH_dom-like PF14714.1 KOO25949.1 - 2.9e-29 100.8 0.0 9.9e-29 99.1 0.0 1.9 2 0 0 2 2 2 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal FeoB_N PF02421.13 KOO25949.1 - 3.9e-23 81.4 0.0 4.1e-13 48.9 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.22 KOO25949.1 - 6e-18 64.9 0.4 1.3e-08 34.5 0.0 4.8 3 3 0 3 3 3 2 Elongation factor Tu GTP binding domain Miro PF08477.8 KOO25949.1 - 2.2e-14 53.9 0.0 1.7e-07 31.7 0.0 2.4 2 0 0 2 2 2 2 Miro-like protein AIG1 PF04548.11 KOO25949.1 - 6.6e-12 44.9 0.1 4.5e-05 22.6 0.0 2.2 2 0 0 2 2 2 2 AIG1 family Dynamin_N PF00350.18 KOO25949.1 - 4.5e-09 36.3 0.0 0.036 13.8 0.1 3.6 3 1 1 4 4 3 3 Dynamin family AAA_18 PF13238.1 KOO25949.1 - 1.3e-07 31.9 0.0 0.00047 20.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 KOO25949.1 - 4.8e-07 29.9 0.5 0.034 14.2 0.0 3.4 3 2 0 3 3 2 2 AAA domain DUF258 PF03193.11 KOO25949.1 - 3.3e-06 26.3 0.0 0.033 13.3 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Ras PF00071.17 KOO25949.1 - 8.8e-06 25.1 0.5 0.0059 16.0 0.0 3.1 3 1 0 3 3 3 1 Ras family PduV-EutP PF10662.4 KOO25949.1 - 1.1e-05 24.9 0.0 0.031 13.7 0.0 3.8 4 0 0 4 4 4 1 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.5 KOO25949.1 - 1.9e-05 23.9 0.1 0.083 12.1 0.0 3.9 3 1 0 3 3 3 1 Signal recognition particle receptor beta subunit AAA_17 PF13207.1 KOO25949.1 - 2.4e-05 25.1 0.1 0.0072 17.1 0.0 2.8 2 1 0 2 2 2 1 AAA domain cobW PF02492.14 KOO25949.1 - 5e-05 22.8 1.1 0.003 17.0 0.0 3.2 2 2 1 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.1 KOO25949.1 - 7.7e-05 22.7 0.9 0.4 10.6 0.0 3.3 4 0 0 4 4 3 2 AAA domain ABC_tran PF00005.22 KOO25949.1 - 0.00012 22.4 0.0 0.45 10.8 0.0 2.5 2 0 0 2 2 2 2 ABC transporter Arf PF00025.16 KOO25949.1 - 0.00015 21.0 0.1 0.16 11.2 0.1 3.0 2 1 0 2 2 2 1 ADP-ribosylation factor family SRP54 PF00448.17 KOO25949.1 - 0.00017 21.0 0.8 0.51 9.7 0.0 2.9 3 0 0 3 3 3 2 SRP54-type protein, GTPase domain MobB PF03205.9 KOO25949.1 - 0.00035 20.2 0.2 1.2 8.7 0.0 3.4 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B ArgK PF03308.11 KOO25949.1 - 0.00064 18.5 0.2 0.21 10.3 0.0 2.8 3 0 0 3 3 3 1 ArgK protein RNA_helicase PF00910.17 KOO25949.1 - 0.00067 19.7 0.0 0.36 11.0 0.0 2.7 3 0 0 3 3 2 1 RNA helicase KTI12 PF08433.5 KOO25949.1 - 0.0027 16.9 0.0 0.059 12.5 0.0 2.7 3 0 0 3 3 3 1 Chromatin associated protein KTI12 AAA_25 PF13481.1 KOO25949.1 - 0.0039 16.6 0.3 0.32 10.3 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KOO25949.1 - 0.0053 16.7 1.6 12 5.7 0.0 4.1 3 2 1 4 4 4 0 AAA ATPase domain 6PF2K PF01591.13 KOO25949.1 - 0.0068 15.5 0.2 0.067 12.2 0.0 2.5 2 1 1 3 3 3 1 6-phosphofructo-2-kinase Arch_ATPase PF01637.13 KOO25949.1 - 0.017 14.8 0.1 6.5 6.3 0.0 2.5 2 0 0 2 2 2 0 Archaeal ATPase NTPase_1 PF03266.10 KOO25949.1 - 0.022 14.4 1.0 1.9 8.1 0.0 3.0 3 0 0 3 3 3 0 NTPase AAA_10 PF12846.2 KOO25949.1 - 0.024 14.1 0.1 1.9 7.8 0.0 2.7 3 0 0 3 3 3 0 AAA-like domain AAA PF00004.24 KOO25949.1 - 0.041 14.0 0.3 14 5.8 0.0 3.2 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 KOO25949.1 - 0.052 13.4 0.1 5.4 6.9 0.0 2.7 3 0 0 3 3 2 0 AAA domain AAA_29 PF13555.1 KOO25949.1 - 0.071 12.6 0.0 8.8 5.9 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain Zeta_toxin PF06414.7 KOO25949.1 - 0.095 11.7 0.1 0.4 9.7 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin ATP-synt_ab PF00006.20 KOO25949.1 - 0.1 12.0 0.0 10 5.5 0.0 2.7 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Parvo_NS1 PF01057.12 KOO25949.1 - 0.12 11.1 0.0 0.28 9.9 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 LZ_Tnp_IS66 PF13007.2 KOO25949.1 - 0.26 11.9 6.3 0.68 10.6 4.4 1.6 1 0 0 1 1 1 0 Transposase C of IS166 homeodomain Pkinase PF00069.20 KOO25950.1 - 2.1e-10 40.2 0.0 2.2e-10 40.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO25950.1 - 0.0057 15.7 0.0 0.0067 15.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase HA2 PF04408.18 KOO25951.1 - 6.5e-14 51.7 0.1 6.8e-11 42.0 0.0 2.8 2 0 0 2 2 2 2 Helicase associated domain (HA2) Helicase_C PF00271.26 KOO25951.1 - 3.9e-11 42.6 0.0 6.8e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Acyl_transf_3 PF01757.17 KOO25952.1 - 2.9e-18 65.8 11.3 2.9e-18 65.8 7.9 3.3 3 0 0 3 3 3 2 Acyltransferase family TraS PF10624.4 KOO25952.1 - 0.069 12.7 0.4 0.18 11.3 0.2 1.6 1 0 0 1 1 1 0 Plasmid conjugative transfer entry exclusion protein TraS Cytochrom_B559 PF00283.14 KOO25952.1 - 0.086 12.1 0.6 0.29 10.4 0.4 1.9 1 0 0 1 1 1 0 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits Metallophos PF00149.23 KOO25953.1 - 0.013 14.9 0.3 0.023 14.1 0.2 1.4 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase GTP_cyclohydro2 PF00925.15 KOO25955.1 - 3.4e-40 137.0 0.0 4.3e-40 136.7 0.0 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase II Cyclin_N PF00134.18 KOO25956.1 - 2.2e-21 75.7 0.1 3.9e-21 74.9 0.0 1.5 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 KOO25956.1 - 0.0026 17.6 0.2 0.098 12.5 0.1 2.2 2 0 0 2 2 2 1 Cyclin, C-terminal domain DEAD PF00270.24 KOO25957.1 - 0.036 13.5 0.0 0.095 12.1 0.0 1.6 1 1 0 1 1 1 0 DEAD/DEAH box helicase Nuc_deoxyrib_tr PF05014.10 KOO25958.1 - 0.87 9.4 0.0 0.87 9.4 0.0 3.0 3 1 0 3 3 3 0 Nucleoside 2-deoxyribosyltransferase GET2 PF08690.5 KOO25958.1 - 1.3 8.1 0.0 1.3 8.1 0.0 2.3 2 0 0 2 2 2 0 GET complex subunit GET2 FtsJ PF01728.14 KOO25959.1 - 3.6e-20 72.6 0.0 6.2e-20 71.9 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase WW PF00397.21 KOO25959.1 - 0.00037 20.3 0.1 0.00085 19.1 0.1 1.6 1 0 0 1 1 1 1 WW domain Nucleotid_trans PF03407.11 KOO25960.1 - 3.9e-10 39.8 0.0 5.2e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase KGG PF10685.4 KOO25962.1 - 0.069 13.1 1.6 0.13 12.2 1.1 1.4 1 0 0 1 1 1 0 Stress-induced bacterial acidophilic repeat motif Ferrochelatase PF00762.14 KOO25964.1 - 3.7e-108 361.2 0.0 4.4e-108 361.0 0.0 1.1 1 0 0 1 1 1 1 Ferrochelatase CbiX PF01903.12 KOO25964.1 - 0.0016 18.5 0.0 1.1 9.4 0.0 2.8 3 0 0 3 3 3 2 CbiX Peptidase_M19 PF01244.16 KOO25965.1 - 0.21 10.4 0.0 0.33 9.8 0.0 1.2 1 0 0 1 1 1 0 Membrane dipeptidase (Peptidase family M19) GST_N_3 PF13417.1 KOO25966.1 - 3.7e-13 49.5 0.0 1.4e-12 47.6 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 KOO25966.1 - 1.1e-10 41.3 0.1 2.9e-10 39.9 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KOO25966.1 - 1.4e-09 37.6 1.2 4.9e-09 35.9 0.7 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 KOO25966.1 - 0.00018 21.6 0.0 0.00054 20.0 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 KOO25966.1 - 0.00099 19.5 0.0 0.002 18.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 KOO25966.1 - 0.053 13.5 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF1917 PF08939.5 KOO25967.1 - 8.5e-21 74.8 0.8 3.3e-20 72.8 0.1 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF1917) SNF2_N PF00176.18 KOO25968.1 - 3.2e-20 72.1 0.0 5.1e-20 71.4 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 KOO25968.1 - 0.00042 19.8 0.0 0.58 9.6 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.10 KOO25968.1 - 0.0011 18.8 0.0 0.004 17.0 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 KOO25968.1 - 0.0031 17.6 0.0 0.037 14.1 0.0 2.6 3 0 0 3 3 3 1 AAA domain DUF4604 PF15377.1 KOO25968.1 - 0.051 13.7 3.3 0.5 10.5 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) CRAL_TRIO_2 PF13716.1 KOO25969.1 - 2.2e-27 95.7 0.0 3.7e-27 95.0 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Macro PF01661.16 KOO25969.1 - 1.5e-21 76.4 0.1 4.2e-21 75.0 0.1 1.8 1 0 0 1 1 1 1 Macro domain CRAL_TRIO PF00650.15 KOO25969.1 - 0.0001 21.8 0.0 0.00026 20.5 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO domain Baculo_PEP_C PF04513.7 KOO25969.1 - 3.1 7.6 19.8 2.2 8.0 0.3 4.2 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_11 PF13414.1 KOO25970.1 - 2.4e-35 119.9 35.9 1.9e-10 40.2 0.1 8.4 2 2 7 10 10 10 9 TPR repeat TPR_12 PF13424.1 KOO25970.1 - 7.6e-29 99.4 30.0 4.9e-10 39.2 0.1 9.7 6 3 4 10 10 10 6 Tetratricopeptide repeat TPR_2 PF07719.12 KOO25970.1 - 1.9e-27 92.8 32.2 0.0021 17.8 0.0 12.3 14 0 0 14 14 13 7 Tetratricopeptide repeat TPR_1 PF00515.23 KOO25970.1 - 8.8e-27 91.5 31.6 1.7e-06 27.3 0.1 10.9 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_14 PF13428.1 KOO25970.1 - 4.2e-25 85.9 3.1 0.0063 17.0 0.0 10.6 3 3 7 10 10 10 5 Tetratricopeptide repeat TPR_16 PF13432.1 KOO25970.1 - 1.7e-23 82.7 13.7 2.5e-05 24.8 0.1 7.5 5 2 3 8 8 8 6 Tetratricopeptide repeat TPR_19 PF14559.1 KOO25970.1 - 6.1e-23 80.9 12.6 0.00016 21.9 0.0 7.6 7 2 0 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.1 KOO25970.1 - 1.8e-19 67.9 8.3 0.006 16.3 0.0 10.3 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_6 PF13174.1 KOO25970.1 - 2.7e-19 68.2 19.1 0.083 13.3 0.1 11.0 12 0 0 12 12 11 5 Tetratricopeptide repeat Apc3 PF12895.2 KOO25970.1 - 3e-18 65.7 21.1 5.7e-06 26.3 0.3 6.7 4 2 4 8 8 8 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.1 KOO25970.1 - 8.9e-14 50.1 27.5 0.23 11.3 0.0 11.5 12 0 0 12 12 12 4 Tetratricopeptide repeat TPR_21 PF09976.4 KOO25970.1 - 7.2e-11 42.2 7.7 6.7e-07 29.3 1.3 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.1 KOO25970.1 - 1.1e-09 37.9 19.3 0.67 9.9 0.0 9.2 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_17 PF13431.1 KOO25970.1 - 5.4e-07 29.3 17.3 0.76 10.1 0.1 9.9 11 1 0 11 11 10 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOO25970.1 - 3.5e-06 26.7 5.6 0.59 10.0 0.1 5.3 4 2 0 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.1 KOO25970.1 - 0.00089 18.3 7.0 1.6 7.7 0.3 4.6 2 1 3 5 5 5 2 Tetratricopeptide repeat NARP1 PF12569.3 KOO25970.1 - 0.012 14.4 19.0 0.15 10.7 4.1 3.7 2 2 1 4 4 4 0 NMDA receptor-regulated protein 1 TPR_4 PF07721.9 KOO25970.1 - 0.02 15.2 0.0 10 6.8 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_20 PF14561.1 KOO25970.1 - 0.29 11.2 12.2 0.91 9.6 0.0 5.9 6 2 1 7 7 7 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO25970.1 - 0.35 10.7 7.9 19 5.2 0.0 5.2 6 0 0 6 6 5 0 Fis1 C-terminal tetratricopeptide repeat RPN7 PF10602.4 KOO25970.1 - 1.2 8.5 19.5 0.028 13.7 0.4 5.8 3 1 3 6 6 6 0 26S proteasome subunit RPN7 Rabaptin PF03528.10 KOO25970.1 - 1.6 8.7 5.2 1.9 8.4 0.7 2.6 2 0 0 2 2 2 0 Rabaptin SHMT PF00464.14 KOO25971.1 - 8e-176 584.2 0.0 9.7e-176 583.9 0.0 1.1 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.16 KOO25971.1 - 0.082 12.0 0.0 0.18 10.9 0.0 1.6 2 0 0 2 2 2 0 Beta-eliminating lyase SelA PF03841.8 KOO25971.1 - 0.2 10.3 0.0 0.34 9.5 0.0 1.3 1 0 0 1 1 1 0 L-seryl-tRNA selenium transferase 2-Hacid_dh_C PF02826.14 KOO25972.1 - 3.2e-41 140.4 0.0 4.7e-41 139.8 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.10 KOO25972.1 - 5.2e-05 23.1 0.0 0.00017 21.4 0.0 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.16 KOO25972.1 - 0.0019 18.0 0.0 0.0035 17.1 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain IlvN PF07991.7 KOO25972.1 - 0.0055 16.0 0.0 0.011 15.0 0.0 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain Shikimate_DH PF01488.15 KOO25972.1 - 0.0058 16.7 0.0 0.014 15.5 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.1 KOO25972.1 - 0.044 13.7 0.1 0.099 12.6 0.1 1.6 1 0 0 1 1 1 0 NADH(P)-binding DUF3185 PF11381.3 KOO25972.1 - 0.068 12.9 0.0 0.48 10.2 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3185) ABC_tran PF00005.22 KOO25973.1 - 1.3e-41 142.0 0.7 2.3e-19 70.0 0.1 4.4 2 2 0 2 2 2 2 ABC transporter SMC_N PF02463.14 KOO25973.1 - 1.3e-12 47.4 0.1 2.4e-05 23.6 0.1 4.0 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 KOO25973.1 - 2e-12 47.7 0.1 0.015 15.3 0.0 4.3 4 0 0 4 4 4 3 AAA domain AAA_29 PF13555.1 KOO25973.1 - 6.7e-08 31.9 0.3 0.0048 16.4 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_17 PF13207.1 KOO25973.1 - 2.5e-06 28.2 0.0 0.084 13.6 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 KOO25973.1 - 4.3e-06 26.9 0.0 0.0031 17.6 0.0 3.3 3 0 0 3 3 2 1 AAA domain AAA_16 PF13191.1 KOO25973.1 - 1.6e-05 25.0 0.6 0.038 13.9 0.0 3.3 3 0 0 3 3 3 1 AAA ATPase domain Miro PF08477.8 KOO25973.1 - 2.2e-05 24.9 0.1 0.48 10.9 0.0 4.0 3 0 0 3 3 3 1 Miro-like protein MobB PF03205.9 KOO25973.1 - 3.4e-05 23.5 0.1 0.14 11.8 0.0 2.9 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B DUF258 PF03193.11 KOO25973.1 - 7.1e-05 22.0 0.1 0.46 9.6 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 ArgK PF03308.11 KOO25973.1 - 8.3e-05 21.4 1.1 0.21 10.3 0.1 3.2 2 1 1 3 3 3 2 ArgK protein RNA_helicase PF00910.17 KOO25973.1 - 0.00011 22.2 0.0 0.2 11.8 0.0 3.1 2 0 0 2 2 2 1 RNA helicase MMR_HSR1 PF01926.18 KOO25973.1 - 0.00018 21.4 0.0 1.1 9.2 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase SbcCD_C PF13558.1 KOO25973.1 - 0.00046 20.0 0.0 0.17 11.8 0.0 3.0 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_14 PF13173.1 KOO25973.1 - 0.00047 20.0 0.0 0.17 11.7 0.0 3.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 KOO25973.1 - 0.00063 19.6 0.0 0.61 9.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 KOO25973.1 - 0.00076 19.6 0.0 0.25 11.5 0.0 2.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.1 KOO25973.1 - 0.0014 17.7 0.0 4.4 6.2 0.0 3.5 3 0 0 3 3 3 0 AAA ATPase domain NACHT PF05729.7 KOO25973.1 - 0.0014 18.2 0.0 0.37 10.4 0.0 2.6 2 0 0 2 2 2 1 NACHT domain HEAT_2 PF13646.1 KOO25973.1 - 0.0017 18.5 4.6 0.019 15.2 0.0 3.3 2 1 1 3 3 3 1 HEAT repeats DUF87 PF01935.12 KOO25973.1 - 0.002 18.0 0.2 0.14 11.9 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function DUF87 AAA_10 PF12846.2 KOO25973.1 - 0.0021 17.5 0.0 1.3 8.4 0.0 2.7 2 0 0 2 2 2 1 AAA-like domain Chromo PF00385.19 KOO25973.1 - 0.0022 17.6 0.2 0.0061 16.2 0.2 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_30 PF13604.1 KOO25973.1 - 0.0023 17.5 0.9 2.9 7.4 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.1 KOO25973.1 - 0.0043 17.3 0.0 1.1 9.5 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.1 KOO25973.1 - 0.0048 17.2 8.6 0.11 12.8 0.0 3.5 2 1 0 2 2 2 1 AAA domain HEAT PF02985.17 KOO25973.1 - 0.0056 16.6 0.5 1.8 8.8 0.0 4.0 4 0 0 4 4 3 1 HEAT repeat AAA_28 PF13521.1 KOO25973.1 - 0.0059 16.5 0.0 1.2 9.0 0.0 2.9 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.13 KOO25973.1 - 0.0086 15.5 0.6 1.6 8.1 0.0 3.8 4 1 0 4 4 4 1 FtsK/SpoIIIE family AAA_25 PF13481.1 KOO25973.1 - 0.009 15.4 0.1 0.23 10.8 0.0 3.2 3 0 0 3 3 3 1 AAA domain UME PF08064.8 KOO25973.1 - 0.019 14.8 0.0 0.064 13.2 0.0 1.9 1 0 0 1 1 1 0 UME (NUC010) domain DUF815 PF05673.8 KOO25973.1 - 0.019 13.8 0.0 1.8 7.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) MutS_V PF00488.16 KOO25973.1 - 0.021 14.2 0.2 0.34 10.2 0.0 2.3 2 0 0 2 2 2 0 MutS domain V AAA_19 PF13245.1 KOO25973.1 - 0.029 14.1 0.0 5.2 6.8 0.0 2.7 2 0 0 2 2 2 0 Part of AAA domain HEAT_EZ PF13513.1 KOO25973.1 - 0.051 14.0 0.0 1 9.9 0.0 3.0 2 0 0 2 2 2 0 HEAT-like repeat Dynamin_N PF00350.18 KOO25973.1 - 0.15 11.8 3.9 0.64 9.8 0.0 3.5 4 0 0 4 4 3 0 Dynamin family AAA_13 PF13166.1 KOO25973.1 - 1.6 7.1 9.1 7.3 4.9 0.0 3.3 3 0 0 3 3 3 0 AAA domain Got1 PF04178.7 KOO25974.1 - 9e-24 83.8 9.4 1.5e-23 83.1 6.5 1.3 1 0 0 1 1 1 1 Got1/Sft2-like family EAP30 PF04157.11 KOO25974.1 - 0.029 13.5 2.3 0.045 12.8 1.6 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family DUF883 PF05957.8 KOO25974.1 - 0.45 10.9 5.7 0.64 10.4 3.0 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) EFG_IV PF03764.13 KOO25975.1 - 0.071 12.6 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Elongation factor G, domain IV Tmemb_cc2 PF10267.4 KOO25976.1 - 0.0013 17.4 2.7 0.0016 17.1 1.9 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein Rootletin PF15035.1 KOO25976.1 - 0.078 12.9 6.5 0.13 12.2 4.5 1.4 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Spc7 PF08317.6 KOO25976.1 - 0.18 10.4 4.5 0.27 9.8 3.1 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein HlyD PF00529.15 KOO25976.1 - 0.21 10.8 8.3 0.29 10.3 5.7 1.1 1 0 0 1 1 1 0 HlyD family secretion protein HAUS6_N PF14661.1 KOO25976.1 - 0.24 10.7 3.1 0.33 10.2 2.1 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Cortex-I_coil PF09304.5 KOO25976.1 - 0.29 11.1 10.3 0.4 10.7 4.9 2.3 1 1 1 2 2 2 0 Cortexillin I, coiled coil Lzipper-MIP1 PF14389.1 KOO25976.1 - 0.83 9.7 5.9 8.2 6.6 1.7 2.2 1 1 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 DUF745 PF05335.8 KOO25976.1 - 0.89 9.0 7.5 0.51 9.8 2.7 2.0 1 1 2 3 3 3 0 Protein of unknown function (DUF745) Atg14 PF10186.4 KOO25976.1 - 1.2 7.9 6.9 1.6 7.5 4.8 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 IncA PF04156.9 KOO25976.1 - 2.3 7.7 8.8 4.4 6.8 6.1 1.5 1 1 0 1 1 1 0 IncA protein Peptidase_S8 PF00082.17 KOO25977.1 - 2.1e-23 82.8 0.0 3e-23 82.3 0.0 1.2 1 0 0 1 1 1 1 Subtilase family DNA_ligase_A_M PF01068.16 KOO25978.1 - 1.5e-11 44.0 0.0 2e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_OB_2 PF14743.1 KOO25978.1 - 0.00018 21.0 0.0 0.00037 20.0 0.0 1.6 1 0 0 1 1 1 1 DNA ligase OB-like domain ADH_zinc_N_2 PF13602.1 KOO25979.1 - 1.2e-15 58.5 0.1 2.6e-15 57.4 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 KOO25979.1 - 5.9e-14 51.7 0.5 2.4e-13 49.7 0.2 2.1 1 1 1 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOO25979.1 - 1e-10 41.2 0.2 2.3e-10 40.2 0.1 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain NAD_binding_10 PF13460.1 KOO25979.1 - 0.025 14.5 0.1 0.037 14.0 0.1 1.3 1 0 0 1 1 1 0 NADH(P)-binding DUF4402 PF14352.1 KOO25979.1 - 0.09 13.2 0.5 0.22 12.0 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4402) COX15-CtaA PF02628.10 KOO25980.1 - 8.6e-81 271.1 16.5 1.3e-80 270.4 11.4 1.3 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein WD40 PF00400.27 KOO25980.1 - 3.6e-67 220.0 18.9 1.3e-11 43.9 0.1 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat PD40 PF07676.7 KOO25980.1 - 4.5e-10 38.9 2.3 4.8 6.9 0.0 5.6 5 0 0 5 5 5 5 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOO25980.1 - 1.5e-08 34.6 0.1 0.0033 17.1 0.0 3.5 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A DUF1513 PF07433.6 KOO25980.1 - 0.0032 16.4 0.2 4.2 6.1 0.0 3.7 1 1 3 4 4 4 1 Protein of unknown function (DUF1513) DUF3312 PF11768.3 KOO25980.1 - 0.014 13.6 0.0 0.99 7.5 0.0 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF3312) DUF1161 PF06649.7 KOO25980.1 - 0.097 12.6 0.0 12 5.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1161) Dfp1_Him1_M PF08630.5 KOO25980.1 - 0.5 10.1 1.4 62 3.4 0.0 3.5 4 0 0 4 4 4 0 Dfp1/Him1, central region zf-C3HC4_3 PF13920.1 KOO25982.1 - 4.4e-16 58.2 12.9 7.2e-16 57.6 8.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) NHL PF01436.16 KOO25982.1 - 2.6e-12 46.0 0.1 0.0017 18.2 0.0 4.5 4 0 0 4 4 4 3 NHL repeat zf-C3HC4_2 PF13923.1 KOO25982.1 - 1.3e-07 31.5 13.7 2.2e-07 30.7 9.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO25982.1 - 4.5e-05 23.1 13.7 9.2e-05 22.1 9.5 1.6 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.1 KOO25982.1 - 0.0018 17.8 6.5 0.0036 16.8 4.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-P11 PF03854.9 KOO25982.1 - 0.0018 17.6 6.8 0.0036 16.7 4.7 1.5 1 0 0 1 1 1 1 P-11 zinc finger zf-RING_5 PF14634.1 KOO25982.1 - 0.0023 17.6 11.8 0.0039 16.8 8.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Urocanase PF01175.13 KOO25982.1 - 0.18 9.8 0.0 0.27 9.2 0.0 1.1 1 0 0 1 1 1 0 Urocanase zf-RING_4 PF14570.1 KOO25982.1 - 6 6.5 10.5 11 5.7 7.3 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Abi PF02517.11 KOO25983.1 - 5.4e-11 42.4 2.8 5.4e-11 42.4 1.9 2.3 2 1 0 2 2 2 1 CAAX protease self-immunity DUF1144 PF06610.8 KOO25983.1 - 0.0027 17.4 0.9 0.012 15.4 0.1 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF1144) Ribosomal_L16 PF00252.13 KOO25984.1 - 1.5e-32 112.1 0.3 2.2e-32 111.5 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e TPR_11 PF13414.1 KOO25985.1 - 3.6e-23 80.9 26.4 5.8e-15 54.6 2.5 5.0 4 1 1 5 5 5 3 TPR repeat DnaJ PF00226.26 KOO25985.1 - 1e-19 69.9 1.0 2.3e-19 68.8 0.7 1.6 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.12 KOO25985.1 - 2.9e-15 54.8 20.8 0.00014 21.4 0.0 7.4 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_1 PF00515.23 KOO25985.1 - 4.3e-15 54.5 9.9 3.5e-05 23.2 1.1 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOO25985.1 - 1.4e-07 31.6 18.9 0.0083 16.4 0.2 4.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO25985.1 - 7.3e-07 29.7 38.0 0.00081 20.0 2.3 5.7 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.1 KOO25985.1 - 3.2e-05 23.7 24.8 0.032 14.1 3.9 4.9 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO25985.1 - 8.2e-05 22.1 15.1 0.0015 18.1 0.0 5.6 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO25985.1 - 0.00035 20.9 35.0 0.012 16.1 0.1 8.1 4 1 5 9 9 9 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO25985.1 - 0.0038 17.0 0.3 0.0038 17.0 0.2 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO25985.1 - 0.012 15.7 9.7 0.78 10.1 0.7 5.0 5 0 0 5 5 4 0 Tetratricopeptide repeat AAR2 PF05282.6 KOO25985.1 - 0.022 13.6 0.0 0.034 13.0 0.0 1.2 1 0 0 1 1 1 0 AAR2 protein TPR_8 PF13181.1 KOO25985.1 - 0.071 12.9 4.7 4.4 7.3 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO25985.1 - 1.2 9.7 0.0 0.56 10.7 0.2 4.8 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_4 PF07721.9 KOO25985.1 - 2.5 8.7 15.5 0.77 10.3 0.1 5.1 4 0 0 4 4 3 0 Tetratricopeptide repeat DUF1206 PF06724.6 KOO25986.1 - 1 9.1 7.7 1.1 9.0 0.0 2.9 2 1 1 3 3 3 0 Domain of Unknown Function (DUF1206) AAA_13 PF13166.1 KOO25987.1 - 0.0076 14.7 2.6 0.0094 14.4 1.8 1.1 1 0 0 1 1 1 1 AAA domain Osmo_CC PF08946.5 KOO25987.1 - 0.26 11.3 3.3 0.23 11.4 0.6 2.3 2 0 0 2 2 2 0 Osmosensory transporter coiled coil Cortex-I_coil PF09304.5 KOO25987.1 - 0.39 10.7 12.9 0.77 9.8 0.9 2.9 2 1 1 3 3 3 0 Cortexillin I, coiled coil Mto2_bdg PF12808.2 KOO25987.1 - 0.62 10.2 6.1 8 6.6 0.5 3.2 3 0 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF702 PF05142.7 KOO25987.1 - 1.2 9.3 8.0 0.26 11.4 2.4 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF702) SlyX PF04102.7 KOO25987.1 - 6.8 7.1 8.1 20 5.6 0.2 3.0 3 0 0 3 3 3 0 SlyX Nucleotid_trans PF03407.11 KOO25988.1 - 5.7e-14 52.3 0.0 1.1e-13 51.5 0.0 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase tRNA-synt_2d PF01409.15 KOO25990.1 - 6.5e-87 290.8 0.0 9.4e-87 290.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2 PF00152.15 KOO25990.1 - 3.3e-05 22.8 0.3 6.6e-05 21.8 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.20 KOO25990.1 - 0.00027 20.5 0.1 0.00043 19.9 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Arm PF00514.18 KOO25991.1 - 2e-06 27.3 26.6 0.002 17.8 0.8 7.6 9 0 0 9 9 9 4 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO25991.1 - 0.0034 17.6 5.4 0.0034 17.6 3.8 6.5 5 2 3 8 8 8 2 HEAT repeats HEAT_EZ PF13513.1 KOO25991.1 - 0.06 13.8 39.2 0.04 14.4 4.5 6.6 6 0 0 6 6 6 0 HEAT-like repeat HEAT PF02985.17 KOO25991.1 - 3.4 7.9 25.4 6.4 7.1 0.4 7.0 6 0 0 6 6 6 0 HEAT repeat 2OG-FeII_Oxy_3 PF13640.1 KOO25992.1 - 8.2e-07 29.4 1.5 2.9e-06 27.7 1.0 2.0 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO25992.1 - 0.00024 21.3 0.5 0.0049 17.1 0.4 2.4 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO25992.1 - 0.035 13.7 0.1 0.092 12.3 0.0 1.7 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Replic_Relax PF13814.1 KOO25992.1 - 0.04 13.7 0.1 0.083 12.7 0.1 1.5 1 0 0 1 1 1 0 Replication-relaxation CoA_transf_3 PF02515.12 KOO25993.1 - 3.3e-25 88.4 0.2 5.8e-17 61.5 0.0 2.5 2 0 0 2 2 2 2 CoA-transferase family III Ion_trans_2 PF07885.11 KOO25993.1 - 5.2e-14 51.7 3.0 1.2e-13 50.5 2.1 1.6 1 0 0 1 1 1 1 Ion channel Ion_trans PF00520.26 KOO25993.1 - 0.0047 16.2 0.8 0.0081 15.4 0.6 1.3 1 0 0 1 1 1 1 Ion transport protein DUF218 PF02698.12 KOO25994.1 - 8.8e-25 87.0 0.3 1.1e-24 86.6 0.2 1.2 1 0 0 1 1 1 1 DUF218 domain APG6 PF04111.7 KOO25995.1 - 0.1 11.6 5.3 0.11 11.5 3.6 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF2360 PF10152.4 KOO25995.1 - 0.64 10.3 4.6 0.72 10.1 3.2 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) NAM-associated PF14303.1 KOO25995.1 - 0.81 9.9 6.3 1 9.7 4.4 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain OmpH PF03938.9 KOO25995.1 - 2.4 8.0 14.4 2.7 7.9 10.0 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Spore_coat_CotO PF14153.1 KOO25995.1 - 9 5.6 9.0 10 5.5 6.2 1.1 1 0 0 1 1 1 0 Spore coat protein CotO OmpA PF00691.15 KOO25997.1 - 3.8e-20 72.0 5.0 0.04 14.3 0.0 8.7 8 0 0 8 8 8 6 OmpA family EF-hand_1 PF00036.27 KOO25997.1 - 8.9e-10 37.1 0.2 0.00034 19.6 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO25997.1 - 7.3e-08 32.4 0.4 1.7e-07 31.2 0.3 1.6 1 0 0 1 1 1 1 EF-hand domain pair Annexin PF00191.15 KOO25997.1 - 7.4e-08 32.1 0.1 0.0003 20.6 0.0 3.3 3 0 0 3 3 3 2 Annexin EF-hand_6 PF13405.1 KOO25997.1 - 4.8e-06 26.0 0.3 0.0056 16.4 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO25997.1 - 4.6e-05 22.5 0.1 0.086 12.2 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO25997.1 - 0.0011 18.5 0.1 0.0021 17.6 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair Herpes_heli_pri PF05774.6 KOO25997.1 - 1.2 9.1 0.0 2e+02 1.9 0.0 4.1 5 0 0 5 5 5 0 Herpesvirus helicase-primase complex component Nuc_sug_transp PF04142.10 KOO25998.1 - 7e-46 156.2 8.7 1.1e-45 155.5 6.0 1.3 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.15 KOO25998.1 - 2.7e-11 43.5 21.3 2.6e-06 27.4 3.6 2.5 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.6 KOO25998.1 - 2.6e-08 33.1 15.6 3.7e-07 29.3 10.8 2.1 1 1 0 1 1 1 1 UAA transporter family EmrE PF13536.1 KOO25998.1 - 3.5e-06 27.2 4.7 3.5e-06 27.2 3.2 2.7 2 1 0 2 2 2 1 Multidrug resistance efflux transporter TPT PF03151.11 KOO25998.1 - 9.7e-06 25.3 8.1 9.7e-06 25.3 5.6 2.8 2 1 0 2 2 2 1 Triose-phosphate Transporter family Nucleotid_trans PF03407.11 KOO25999.1 - 4.8e-07 29.7 0.0 9.1e-07 28.8 0.0 1.5 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase DUF445 PF04286.7 KOO26000.1 - 5.9e-09 35.9 0.3 7.6e-07 28.9 0.0 3.1 2 2 2 4 4 4 2 Protein of unknown function (DUF445) PQQ_3 PF13570.1 KOO26003.1 - 2e-55 183.6 32.8 2.5e-07 30.7 0.4 8.1 8 0 0 8 8 8 8 PQQ-like domain PQQ PF01011.16 KOO26003.1 - 6e-44 145.4 13.2 6e-07 28.6 0.1 7.7 8 0 0 8 8 8 7 PQQ enzyme repeat PQQ_2 PF13360.1 KOO26003.1 - 5.3e-42 143.9 8.3 2.2e-16 60.0 0.3 3.1 1 1 2 3 3 3 3 PQQ-like domain Cytochrom_D1 PF02239.11 KOO26003.1 - 0.0047 15.2 0.3 8.1 4.6 0.0 3.2 1 1 1 3 3 3 2 Cytochrome D1 heme domain BsuPI PF12690.2 KOO26003.1 - 0.01 15.5 0.0 1.9 8.2 0.0 3.4 3 1 0 3 3 3 0 Intracellular proteinase inhibitor DUF4394 PF14339.1 KOO26003.1 - 0.024 13.9 0.2 6.4 5.9 0.0 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4394) MinC_C PF03775.11 KOO26003.1 - 0.031 13.9 0.1 7 6.3 0.0 2.9 3 1 0 3 3 3 0 Septum formation inhibitor MinC, C-terminal domain WD40 PF00400.27 KOO26003.1 - 0.066 13.1 6.0 2.1 8.3 0.0 4.6 5 0 0 5 5 5 0 WD domain, G-beta repeat Glycolytic PF00274.14 KOO26004.1 - 4.2e-105 350.9 0.0 5.1e-105 350.7 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I Methyltransf_21 PF05050.7 KOO26005.1 - 3e-08 33.7 0.0 3.4e-08 33.6 0.0 1.0 1 0 0 1 1 1 1 Methyltransferase FkbM domain DUF303 PF03629.13 KOO26006.1 - 4.1e-57 193.3 0.0 5.5e-57 192.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF303) EF-hand_1 PF00036.27 KOO26007.1 - 4.3e-21 72.5 9.5 6.3e-06 25.1 0.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO26007.1 - 9e-19 67.3 5.4 8.7e-09 35.4 1.5 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO26007.1 - 3.3e-16 57.6 6.6 0.0014 18.3 0.3 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO26007.1 - 6.1e-14 50.6 16.0 0.00076 18.7 0.1 4.7 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO26007.1 - 2.7e-11 42.8 10.4 6.1e-06 25.7 1.4 3.7 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO26007.1 - 2e-07 30.9 0.2 0.0013 18.7 0.0 3.2 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO26007.1 - 1.1e-06 28.2 1.0 0.00054 19.6 0.0 3.3 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO26007.1 - 0.066 13.1 0.3 9.7 6.1 0.0 3.2 3 0 0 3 3 3 0 EF-hand domain EF-hand_10 PF14788.1 KOO26007.1 - 1 9.0 4.7 10 5.8 0.1 3.3 3 1 1 4 4 4 0 EF hand DegT_DnrJ_EryC1 PF01041.12 KOO26008.1 - 2.9e-68 230.5 0.0 3.9e-68 230.1 0.0 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Epimerase PF01370.16 KOO26008.1 - 6e-45 153.5 0.0 8.5e-45 153.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 KOO26008.1 - 2e-19 69.5 0.0 4.2e-19 68.4 0.0 1.5 1 0 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.12 KOO26008.1 - 5.4e-15 55.0 0.0 8.6e-15 54.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 KOO26008.1 - 8.5e-12 44.5 0.0 4.5e-11 42.1 0.0 2.1 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 KOO26008.1 - 3.4e-11 42.3 0.0 5.1e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 KOO26008.1 - 0.00031 20.7 0.1 0.0016 18.3 0.0 2.2 2 1 0 2 2 2 1 short chain dehydrogenase Aminotran_5 PF00266.14 KOO26008.1 - 0.019 13.7 0.0 0.36 9.5 0.0 2.3 2 0 0 2 2 2 0 Aminotransferase class-V KR PF08659.5 KOO26008.1 - 0.046 13.3 0.0 0.12 12.0 0.0 1.7 1 1 0 1 1 1 0 KR domain Glyco_hydro_53 PF07745.8 KOO26009.1 - 0.0019 17.0 0.0 0.0023 16.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 Hpt PF01627.18 KOO26010.1 - 0.02 14.8 1.0 0.056 13.4 0.7 1.8 1 1 0 1 1 1 0 Hpt domain ABA_GPCR PF12430.3 KOO26011.1 - 3.1e-11 42.7 0.0 6.7e-11 41.6 0.0 1.5 1 0 0 1 1 1 1 Abscisic acid G-protein coupled receptor DUF3735 PF12537.3 KOO26011.1 - 9.9e-05 22.3 0.0 0.00023 21.1 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3735) ABA_GPCR PF12430.3 KOO26012.1 - 0.00012 21.3 0.2 0.00017 20.8 0.1 1.2 1 0 0 1 1 1 1 Abscisic acid G-protein coupled receptor Herpes_capsid PF06112.6 KOO26012.1 - 2.8 7.9 5.6 4.6 7.2 3.9 1.5 1 1 0 1 1 1 0 Gammaherpesvirus capsid protein Ank_2 PF12796.2 KOO26013.1 - 9.7e-13 48.2 1.3 3.9e-11 43.1 0.9 3.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO26013.1 - 4.2e-12 45.8 0.5 2.4e-08 33.9 0.1 3.5 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO26013.1 - 2.3e-08 34.3 0.7 2.8e-06 27.6 0.0 3.4 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO26013.1 - 1.3e-07 31.1 4.4 0.00012 21.9 0.1 5.2 5 1 0 5 5 5 1 Ankyrin repeat Ank PF00023.25 KOO26013.1 - 4.8e-07 29.2 12.7 2.8e-06 26.8 0.1 5.0 5 0 0 5 5 5 2 Ankyrin repeat DAGAT PF03982.8 KOO26014.1 - 1e-35 122.9 0.0 1.3e-35 122.5 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Vint PF14623.1 KOO26015.1 - 5.8e-33 113.6 0.0 1.3e-32 112.5 0.0 1.6 1 0 0 1 1 1 1 Hint-domain VWA_2 PF13519.1 KOO26015.1 - 4e-14 53.0 0.1 8.8e-14 51.9 0.0 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.23 KOO26015.1 - 3.4e-07 30.1 0.0 5.8e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Vwaint PF14624.1 KOO26015.1 - 3.2e-06 27.1 0.0 5.8e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 VWA / Hh protein intein-like Hint PF01079.15 KOO26015.1 - 0.045 12.9 0.0 0.097 11.8 0.0 1.5 1 0 0 1 1 1 0 Hint module Hom_end_hint PF05203.11 KOO26015.1 - 0.083 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Hom_end-associated Hint Thioredoxin_4 PF13462.1 KOO26017.1 - 2.9e-05 24.1 0.0 3.9e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Tudor-knot PF11717.3 KOO26018.1 - 1.9e-19 69.0 0.8 1.2e-08 34.5 0.0 2.9 3 0 0 3 3 3 2 RNA binding activity-knot of a chromodomain MBT PF02820.13 KOO26018.1 - 8.4e-05 22.4 0.0 0.046 13.6 0.0 2.9 2 0 0 2 2 2 2 mbt repeat Chromo PF00385.19 KOO26018.1 - 0.00064 19.3 0.1 0.59 9.8 0.0 2.4 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Med15 PF09606.5 KOO26019.1 - 0.0059 14.8 0.0 0.011 13.9 0.0 1.3 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal DUF3349 PF11829.3 KOO26019.1 - 0.11 12.9 0.0 0.18 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3349) Metallophos PF00149.23 KOO26020.1 - 4.6e-11 42.4 0.0 6.9e-11 41.9 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase RNA_pol_Rpb2_6 PF00562.23 KOO26021.1 - 5.4e-105 351.3 0.0 8.2e-105 350.7 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 KOO26021.1 - 1.2e-30 105.9 0.0 2.8e-30 104.7 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.15 KOO26021.1 - 8.4e-17 61.2 0.0 2e-16 60.0 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.9 KOO26021.1 - 6.8e-16 58.2 0.0 1e-15 57.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 HTH_Tnp_1 PF01527.15 KOO26021.1 - 2.6e-08 33.7 0.0 6.2e-08 32.4 0.0 1.7 1 0 0 1 1 1 1 Transposase RNA_pol_Rpb2_3 PF04565.11 KOO26021.1 - 0.024 14.4 0.0 0.051 13.3 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 3 DUF2475 PF10629.4 KOO26022.1 - 0.018 15.2 10.2 0.071 13.3 0.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2475) Snf7 PF03357.16 KOO26023.1 - 1.8e-21 76.3 32.6 3.6e-12 45.9 5.2 4.2 3 2 1 4 4 4 2 Snf7 DUF1247 PF06851.6 KOO26023.1 - 0.2 11.2 4.5 1.3 8.6 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1247) DUF3280 PF11684.3 KOO26023.1 - 2.7 8.1 9.6 0.46 10.6 3.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2380) TPR_11 PF13414.1 KOO26025.1 - 9e-11 41.2 13.4 3e-07 29.9 6.1 2.7 1 1 2 3 3 3 3 TPR repeat TPR_2 PF07719.12 KOO26025.1 - 0.00042 20.0 11.8 0.65 10.0 1.2 4.4 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO26025.1 - 0.00066 19.6 0.2 7.9 6.9 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO26025.1 - 0.0058 16.1 12.5 5.1 6.8 1.4 5.3 4 2 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO26025.1 - 0.019 15.6 6.5 0.019 15.6 4.5 3.8 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO26025.1 - 0.31 11.7 10.9 1.6 9.5 0.0 4.2 1 1 4 5 5 5 0 Tetratricopeptide repeat LVIVD PF08309.6 KOO26026.1 - 3.6e-37 125.0 58.1 3.9e-11 41.7 2.5 7.3 6 1 1 7 7 7 7 LVIVD repeat SBP56 PF05694.6 KOO26026.1 - 0.0075 14.8 0.1 1.2 7.5 0.0 2.5 1 1 1 2 2 2 2 56kDa selenium binding protein (SBP56) PSCyt3 PF07627.6 KOO26026.1 - 0.14 12.0 0.1 23 4.9 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1588) Chitin_bind_4 PF00379.18 KOO26026.1 - 0.33 11.2 22.5 23 5.3 0.1 7.1 7 0 0 7 7 7 0 Insect cuticle protein DUF150 PF02576.12 KOO26027.1 - 6.9e-07 28.9 0.0 8.7e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised BCR, YhbC family COG0779 Nol1_Nop2_Fmu PF01189.12 KOO26028.1 - 0.0021 17.5 0.0 0.011 15.1 0.0 1.9 2 0 0 2 2 2 1 NOL1/NOP2/sun family Bestrophin PF01062.16 KOO26029.1 - 5.2e-20 71.5 2.7 6e-20 71.3 1.9 1.0 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel PapJ PF14855.1 KOO26030.1 - 0.14 11.6 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Pilus-assembly fibrillin subunit, chaperone PARP PF00644.15 KOO26031.1 - 4.1e-11 42.7 0.0 2.2e-10 40.3 0.0 1.9 1 1 1 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain PP-binding PF00550.20 KOO26032.1 - 3.1e-05 24.1 0.0 6e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Phosphopantetheine attachment site zf-TAZ PF02135.11 KOO26035.1 - 0.036 14.0 6.0 0.064 13.2 4.2 1.3 1 0 0 1 1 1 0 TAZ zinc finger Spatacsin_C PF14649.1 KOO26035.1 - 0.08 11.7 0.1 0.12 11.2 0.1 1.1 1 0 0 1 1 1 0 Spatacsin C-terminus Kinesin PF00225.18 KOO26037.1 - 6.4e-87 291.3 0.0 1.2e-86 290.5 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain TPR_12 PF13424.1 KOO26037.1 - 0.014 15.2 0.1 0.058 13.3 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat AAA_22 PF13401.1 KOO26037.1 - 0.034 14.2 0.5 0.15 12.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain Cpn60_TCP1 PF00118.19 KOO26038.1 - 3.5e-141 471.1 11.8 4e-141 470.9 8.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FliL PF03748.9 KOO26038.1 - 0.038 13.9 0.7 0.12 12.3 0.1 2.2 2 0 0 2 2 2 0 Flagellar basal body-associated protein FliL 2OG-FeII_Oxy_3 PF13640.1 KOO26040.1 - 7.6e-11 42.4 0.0 1.2e-10 41.8 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO26040.1 - 0.00043 20.5 0.0 0.0006 20.0 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ring_hydroxyl_A PF00848.14 KOO26040.1 - 0.14 11.7 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Ring hydroxylating alpha subunit (catalytic domain) MFS_1 PF07690.11 KOO26041.1 - 1.3e-23 83.3 31.1 1.3e-23 83.3 21.5 2.3 1 1 2 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.19 KOO26041.1 - 1.1e-07 30.8 2.4 1.1e-07 30.8 1.7 2.4 1 1 0 2 2 2 1 Sugar (and other) transporter TraD PF06412.6 KOO26041.1 - 2.4 7.8 8.0 3 7.5 0.1 3.5 4 0 0 4 4 4 0 Conjugal transfer protein TraD zf-C3HC4_3 PF13920.1 KOO26042.1 - 6.5e-09 35.3 11.9 1.1e-08 34.6 8.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Arm PF00514.18 KOO26042.1 - 0.0004 20.1 0.1 1.5 8.7 0.0 2.7 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat zf-C3HC4_2 PF13923.1 KOO26042.1 - 0.58 10.2 14.7 1 9.4 10.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.1 KOO26042.1 - 5.8 6.5 8.7 12 5.4 6.1 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 FoP_duplication PF13865.1 KOO26042.1 - 6.4 7.2 10.6 3.1 8.2 2.6 2.9 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 Glyco_transf_34 PF05637.7 KOO26043.1 - 4.6e-26 91.7 0.2 2.5e-13 50.0 0.1 3.1 1 1 2 3 3 3 3 galactosyl transferase GMA12/MNN10 family Nucleotid_trans PF03407.11 KOO26043.1 - 0.0002 21.2 0.1 0.00035 20.4 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase DUF273 PF03314.9 KOO26043.1 - 0.0059 15.9 0.0 0.0092 15.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF273 DUF2183 PF09949.4 KOO26043.1 - 0.15 11.9 0.0 0.38 10.7 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2183) NIF PF03031.13 KOO26044.1 - 4.3e-23 81.7 0.0 6e-23 81.2 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HisKA_3 PF07730.8 KOO26044.1 - 0.11 12.8 0.1 25 5.3 0.1 3.3 3 0 0 3 3 3 0 Histidine kinase BTB PF00651.26 KOO26045.1 - 1.5e-24 86.0 0.0 2.4e-24 85.4 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 KOO26045.1 - 1.5e-17 63.2 0.0 5.9e-17 61.3 0.0 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch Skp1 PF01466.14 KOO26045.1 - 0.016 15.1 0.1 0.084 12.9 0.0 2.2 2 1 1 3 3 3 0 Skp1 family, dimerisation domain Arm PF00514.18 KOO26046.1 - 4.1e-06 26.4 7.5 0.18 11.6 1.2 5.3 4 2 0 4 4 4 3 Armadillo/beta-catenin-like repeat HEAT PF02985.17 KOO26046.1 - 0.034 14.2 0.3 18 5.7 0.0 4.0 3 0 0 3 3 3 0 HEAT repeat PTR2 PF00854.16 KOO26047.1 - 2.5e-31 108.7 5.4 9.5e-22 77.2 1.6 2.2 2 0 0 2 2 2 2 POT family MFS_1 PF07690.11 KOO26047.1 - 1.5e-15 56.7 15.7 1.5e-15 56.7 10.9 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Pyr_redox_dim PF02852.17 KOO26048.1 - 3.9e-26 91.2 0.0 5.9e-26 90.6 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.9 KOO26048.1 - 1.3e-24 87.2 1.5 6e-22 78.5 0.2 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOO26048.1 - 2.3e-13 50.3 2.5 1e-09 38.6 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 KOO26048.1 - 4.9e-10 38.8 3.4 2.4e-06 26.6 0.1 2.7 3 0 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 KOO26048.1 - 1.1e-09 38.6 0.0 3.6e-09 36.9 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 KOO26048.1 - 8.4e-06 24.9 0.0 1.7e-05 23.9 0.0 1.4 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.2 KOO26048.1 - 1e-05 24.8 0.6 1.5e-05 24.2 0.4 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.17 KOO26048.1 - 1.1e-05 24.5 2.5 0.00018 20.5 0.5 2.4 2 0 0 2 2 2 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.16 KOO26048.1 - 4.8e-05 22.9 0.5 0.088 12.3 0.0 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.19 KOO26048.1 - 7e-05 21.8 6.8 0.00065 18.6 0.5 2.8 3 0 0 3 3 3 2 FAD binding domain NAD_binding_8 PF13450.1 KOO26048.1 - 0.00032 20.6 7.6 0.04 13.9 0.6 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 KOO26048.1 - 0.00052 18.6 1.0 0.0022 16.5 0.1 2.3 3 0 0 3 3 3 1 HI0933-like protein Thi4 PF01946.12 KOO26048.1 - 0.002 17.2 2.6 0.018 14.1 0.1 2.8 3 0 0 3 3 3 1 Thi4 family NAD_binding_7 PF13241.1 KOO26048.1 - 0.0037 17.5 0.1 0.089 13.0 0.0 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding XdhC_C PF13478.1 KOO26048.1 - 0.0046 17.2 0.1 0.88 9.8 0.0 2.4 2 0 0 2 2 2 1 XdhC Rossmann domain FAD_binding_3 PF01494.14 KOO26048.1 - 0.039 12.9 4.1 1.5 7.7 0.1 2.8 3 0 0 3 3 3 0 FAD binding domain 3HCDH_N PF02737.13 KOO26048.1 - 0.043 13.4 0.3 11 5.6 0.0 2.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.7 KOO26048.1 - 0.1 11.4 1.6 0.13 11.1 0.1 1.9 3 0 0 3 3 3 0 Lycopene cyclase protein NAD_binding_10 PF13460.1 KOO26048.1 - 0.14 12.1 0.9 1.4 8.9 0.0 2.4 2 0 0 2 2 2 0 NADH(P)-binding UDPG_MGDP_dh_N PF03721.9 KOO26048.1 - 1.3 8.3 4.1 0.31 10.3 0.2 1.8 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain SHNi-TPR PF10516.4 KOO26049.1 - 3e-08 32.7 0.0 6.7e-08 31.6 0.0 1.7 1 0 0 1 1 1 1 SHNi-TPR TPR_12 PF13424.1 KOO26049.1 - 0.0002 21.2 3.7 0.0002 21.2 2.6 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOO26049.1 - 0.017 14.7 1.7 0.017 14.7 1.2 2.3 3 0 0 3 3 3 0 TPR repeat DUF4020 PF13212.1 KOO26049.1 - 0.096 12.2 0.2 6 6.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4020) Nup_retrotrp_bd PF10599.4 KOO26049.1 - 0.49 11.0 4.5 1.1 9.9 3.1 1.6 1 0 0 1 1 1 0 Retro-transposon transporting motif TFIIA PF03153.8 KOO26049.1 - 9.2 6.0 14.6 2.9 7.7 2.8 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF3506 PF12014.3 KOO26050.1 - 0.00023 20.9 0.1 0.0012 18.6 0.0 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF3506) DUF2880 PF11082.3 KOO26050.1 - 0.003 17.4 0.0 0.0048 16.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2880) EF-hand_8 PF13833.1 KOO26053.1 - 1.1e-11 44.1 1.4 1.1e-05 24.8 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO26053.1 - 2.8e-09 36.0 8.1 0.0021 17.7 0.1 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.1 KOO26053.1 - 6.4e-09 35.8 6.2 0.00028 20.9 0.2 4.0 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO26053.1 - 2.1e-08 32.8 6.6 0.0025 16.9 0.2 4.2 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.1 KOO26053.1 - 3.3e-05 23.0 3.8 0.013 14.8 0.1 3.5 3 0 0 3 3 3 2 EF hand TMF_DNA_bd PF12329.3 KOO26053.1 - 0.028 14.2 1.6 0.028 14.2 1.1 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding GspL_C PF12693.2 KOO26053.1 - 0.11 12.2 4.9 0.14 11.9 0.1 2.8 2 1 1 3 3 3 0 GspL periplasmic domain Dak2 PF02734.12 KOO26053.1 - 0.11 12.1 5.6 0.52 9.9 3.9 2.0 1 1 0 1 1 1 0 DAK2 domain DUF2203 PF09969.4 KOO26053.1 - 0.57 10.4 3.1 4.6 7.4 0.3 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Peptidase_S41 PF03572.13 KOO26054.1 - 9.4e-38 129.2 0.0 1.3e-37 128.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S41 PDZ PF00595.19 KOO26054.1 - 3.5e-06 27.0 0.2 4.9e-05 23.4 0.0 2.3 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO26054.1 - 4.8e-05 23.1 0.2 9.7e-05 22.1 0.1 1.4 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.1 KOO26054.1 - 0.012 15.4 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 Tricorn protease PDZ domain C2 PF00168.25 KOO26055.1 - 3.6e-09 36.3 0.0 6.7e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 C2 domain DUF1730 PF08331.5 KOO26055.1 - 0.092 12.4 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1730) GntR PF00392.16 KOO26056.1 - 0.058 12.8 1.4 5 6.6 0.0 3.3 3 0 0 3 3 3 0 Bacterial regulatory proteins, gntR family COX15-CtaA PF02628.10 KOO26058.1 - 0.00051 19.0 7.3 0.053 12.3 0.1 2.6 2 1 0 2 2 2 2 Cytochrome oxidase assembly protein DUF2306 PF10067.4 KOO26058.1 - 0.00056 19.9 5.0 0.096 12.8 0.1 3.6 2 1 1 3 3 3 1 Predicted membrane protein (DUF2306) DUF2427 PF10348.4 KOO26058.1 - 0.0081 15.7 7.8 0.67 9.5 0.1 3.2 3 1 0 3 3 3 2 Domain of unknown function (DUF2427) Cytochrom_B561 PF03188.11 KOO26058.1 - 0.0096 15.7 4.1 0.0098 15.7 0.1 2.5 3 0 0 3 3 3 1 Eukaryotic cytochrome b561 MscS_TM PF12794.2 KOO26058.1 - 0.026 13.1 0.1 0.58 8.7 0.0 2.1 1 1 1 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 Cytochrom_C_asm PF01578.15 KOO26058.1 - 0.046 13.2 1.0 0.079 12.4 0.7 1.4 1 1 0 1 1 1 0 Cytochrome C assembly protein DUF4401 PF14351.1 KOO26058.1 - 0.081 11.9 2.8 0.033 13.1 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4401) VWA_2 PF13519.1 KOO26061.1 - 1.7e-11 44.5 0.8 4e-11 43.3 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain SecA_DEAD PF07517.9 KOO26061.1 - 2.3e-09 36.9 0.0 2.1e-08 33.7 0.0 2.7 3 0 0 3 3 3 1 SecA DEAD-like domain VWA PF00092.23 KOO26061.1 - 0.00017 21.3 0.0 0.00054 19.7 0.0 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain MMR_HSR1 PF01926.18 KOO26061.1 - 0.00029 20.7 0.0 0.00087 19.2 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.17 KOO26061.1 - 0.022 14.9 0.0 0.52 10.5 0.0 3.0 3 0 0 3 3 3 0 RNA helicase AAA_29 PF13555.1 KOO26061.1 - 0.043 13.3 0.0 0.13 11.7 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_17 PF13207.1 KOO26061.1 - 0.13 13.1 3.5 1.2 9.9 0.0 3.8 3 0 0 3 3 3 0 AAA domain AAA_23 PF13476.1 KOO26061.1 - 0.59 10.4 0.0 3 8.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain Glyco_transf_25 PF01755.12 KOO26062.1 - 2.5e-20 72.9 0.0 7.4e-20 71.4 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) YHYH PF14240.1 KOO26064.1 - 2.9e-30 105.1 18.3 2e-24 86.1 0.6 2.8 2 1 0 2 2 2 2 YHYH protein Hint PF01079.15 KOO26064.1 - 4.8e-22 78.2 0.1 7.6e-22 77.5 0.1 1.2 1 0 0 1 1 1 1 Hint module Lipase_GDSL_2 PF13472.1 KOO26065.1 - 0.043 13.9 0.2 0.13 12.4 0.1 1.9 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family DUF3449 PF11931.3 KOO26066.1 - 2.5e-70 236.0 0.0 3.5e-70 235.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3449) Telomere_Sde2_2 PF13297.1 KOO26066.1 - 6.5e-24 82.9 0.6 1.4e-23 81.8 0.4 1.6 1 0 0 1 1 1 1 Telomere stability C-terminal SF3a60_bindingd PF12108.3 KOO26066.1 - 7e-06 25.4 0.2 1.3e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain FAM178 PF14816.1 KOO26066.1 - 1 7.9 2.6 1.6 7.3 1.8 1.2 1 0 0 1 1 1 0 Family of unknown function, FAM178 tRNA_bind PF01588.15 KOO26067.1 - 3.9e-28 97.1 0.0 1e-27 95.8 0.0 1.7 2 0 0 2 2 2 1 Putative tRNA binding domain GST_C_2 PF13410.1 KOO26067.1 - 5.3e-07 29.4 0.1 9.6e-07 28.6 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 KOO26067.1 - 9.5e-06 26.0 0.0 1.9e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 KOO26067.1 - 0.0096 15.8 0.0 0.019 14.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Fer2 PF00111.22 KOO26068.1 - 4e-18 64.9 3.8 1.1e-17 63.5 1.3 2.5 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPR_12 PF13424.1 KOO26068.1 - 0.68 9.9 9.6 2.2 8.2 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Pro_CA PF00484.14 KOO26069.1 - 7.1e-26 91.0 0.1 9e-26 90.7 0.1 1.1 1 0 0 1 1 1 1 Carbonic anhydrase RCC1 PF00415.13 KOO26070.1 - 6e-51 170.4 30.9 1.4e-13 50.7 0.1 8.5 7 3 1 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO26070.1 - 1.5e-30 104.1 31.4 8.6e-09 34.7 1.5 6.8 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat PapC_C PF13953.1 KOO26070.1 - 0.08 12.6 0.1 6.1 6.5 0.0 2.6 2 0 0 2 2 2 0 PapC C-terminal domain Kelch_4 PF13418.1 KOO26070.1 - 0.9 9.3 4.5 11 5.8 0.1 3.6 4 0 0 4 4 4 0 Galactose oxidase, central domain AAA PF00004.24 KOO26071.1 - 4.1e-18 65.8 0.0 5.4e-18 65.4 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BCS1_N PF08740.6 KOO26071.1 - 3.8e-06 26.6 0.3 5.7e-06 26.0 0.2 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA_17 PF13207.1 KOO26071.1 - 2.3e-05 25.1 0.0 4.2e-05 24.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 KOO26071.1 - 0.00027 20.3 0.0 0.00039 19.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOO26071.1 - 0.0016 18.4 0.3 0.0036 17.2 0.2 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 KOO26071.1 - 0.0018 18.1 0.0 0.0026 17.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.8 KOO26071.1 - 0.0079 15.1 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_28 PF13521.1 KOO26071.1 - 0.021 14.7 0.1 0.069 13.1 0.0 1.8 1 1 1 2 2 2 0 AAA domain AAA_29 PF13555.1 KOO26071.1 - 0.028 13.9 0.0 0.11 12.0 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain Viral_helicase1 PF01443.13 KOO26071.1 - 0.032 13.7 0.0 0.045 13.2 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.17 KOO26071.1 - 0.034 14.3 0.0 0.056 13.6 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.9 KOO26071.1 - 0.035 13.8 0.0 0.077 12.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) KaiC PF06745.8 KOO26071.1 - 0.04 13.0 0.0 0.065 12.3 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_19 PF13245.1 KOO26071.1 - 0.042 13.6 0.5 0.12 12.1 0.1 2.1 2 1 0 2 2 2 0 Part of AAA domain ABC_tran PF00005.22 KOO26071.1 - 0.076 13.3 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.7 KOO26071.1 - 0.1 12.2 0.0 0.3 10.7 0.0 1.7 2 1 0 2 2 2 0 NACHT domain AAA_22 PF13401.1 KOO26071.1 - 0.13 12.4 0.0 0.22 11.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.1 KOO26071.1 - 0.13 12.1 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 KOO26071.1 - 0.16 11.0 0.0 0.25 10.3 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin Rad17 PF03215.10 KOO26071.1 - 0.17 10.5 0.0 0.22 10.1 0.0 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein OTU PF02338.14 KOO26072.1 - 6.7e-11 42.8 0.0 8.4e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 OTU-like cysteine protease PsbM PF05151.7 KOO26073.1 - 3.3e-07 29.7 2.4 3.3e-07 29.7 1.7 2.0 2 0 0 2 2 2 1 Photosystem II reaction centre M protein (PsbM) Methyltransf_26 PF13659.1 KOO26074.1 - 3e-10 40.1 4.6 2.1e-07 31.0 0.1 3.2 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_18 PF12847.2 KOO26074.1 - 1.2e-09 38.6 0.3 1.3e-06 28.9 0.0 2.6 2 0 0 2 2 2 2 Methyltransferase domain PrmA PF06325.8 KOO26074.1 - 1.2e-07 31.1 0.0 2.1e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.1 KOO26074.1 - 1.5e-05 24.6 0.0 0.00023 20.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO26074.1 - 0.00022 20.9 0.0 0.01 15.5 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.14 KOO26074.1 - 0.0024 17.4 0.1 0.0089 15.5 0.0 1.8 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_16 PF10294.4 KOO26074.1 - 0.0055 16.1 0.0 0.27 10.6 0.0 2.2 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_24 PF13578.1 KOO26074.1 - 0.0081 16.9 0.3 0.31 11.8 0.0 3.0 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 KOO26074.1 - 0.011 15.1 0.0 0.026 13.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_11 PF08241.7 KOO26074.1 - 0.013 16.0 0.1 0.38 11.2 0.0 2.6 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.7 KOO26074.1 - 0.02 15.3 0.0 0.1 13.0 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.1 KOO26074.1 - 0.04 14.2 0.1 0.47 10.8 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_32 PF13679.1 KOO26074.1 - 0.044 13.4 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain adh_short_C2 PF13561.1 KOO26076.1 - 2.7e-28 99.3 0.6 3.4e-28 99.0 0.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 KOO26076.1 - 6.3e-28 97.7 4.7 9.5e-28 97.1 3.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOO26076.1 - 3.8e-08 33.2 3.3 5.6e-08 32.6 2.3 1.3 1 0 0 1 1 1 1 KR domain Coatomer_WDAD PF04053.9 KOO26077.1 - 4.8e-129 431.0 0.0 6.6e-129 430.5 0.0 1.2 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.6 KOO26077.1 - 1.6e-107 359.6 0.0 2.3e-107 359.1 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.27 KOO26077.1 - 1.3e-56 186.5 9.9 1.1e-09 37.7 0.1 7.9 8 0 0 8 8 8 6 WD domain, G-beta repeat Nup160 PF11715.3 KOO26077.1 - 0.004 15.3 4.9 0.092 10.8 0.0 3.2 2 1 1 3 3 3 2 Nucleoporin Nup120/160 zf-LSD1 PF06943.7 KOO26077.1 - 0.019 14.5 0.2 0.056 13.0 0.2 1.8 1 0 0 1 1 1 0 LSD1 zinc finger Nucleoporin_N PF08801.6 KOO26077.1 - 0.043 12.5 0.4 6.7 5.3 0.0 3.0 2 1 0 2 2 2 0 Nup133 N terminal like 2Fe-2S_Ferredox PF11591.3 KOO26079.1 - 4.2 7.0 6.4 1.2 8.8 1.0 2.4 2 1 0 2 2 2 0 Ferredoxin chloroplastic transit peptide PAN_4 PF14295.1 KOO26079.1 - 5.5 6.7 10.7 1.3 8.8 1.8 2.6 3 0 0 3 3 3 0 PAN domain bZIP_1 PF00170.16 KOO26080.1 - 0.39 10.7 4.9 0.87 9.5 3.4 1.5 1 0 0 1 1 1 0 bZIP transcription factor RabGAP-TBC PF00566.13 KOO26081.1 - 1.1e-08 34.8 0.0 1.5e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Kelch_3 PF13415.1 KOO26083.1 - 5.8e-40 134.5 3.5 7.5e-11 41.8 0.0 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.1 KOO26083.1 - 3.4e-35 119.5 7.8 3e-08 33.2 0.0 6.0 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO26083.1 - 3.1e-28 97.2 5.4 4.1e-07 29.8 0.1 5.5 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.1 KOO26083.1 - 6.9e-23 79.8 5.8 1.3e-06 28.3 0.0 5.6 5 1 1 6 6 6 5 Kelch motif Kelch_2 PF07646.10 KOO26083.1 - 1e-14 53.5 15.9 0.00015 21.4 0.0 6.3 5 2 0 5 5 5 4 Kelch motif Kelch_1 PF01344.20 KOO26083.1 - 1.6e-14 53.1 2.2 1.7e-06 27.4 0.0 5.7 5 1 0 5 5 5 3 Kelch motif Adaptin_binding PF10199.4 KOO26083.1 - 4.4 7.5 7.9 0.74 10.1 3.0 1.5 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 Radial_spoke PF04712.7 KOO26084.1 - 7.1e-89 298.8 0.0 1e-88 298.3 0.0 1.2 1 0 0 1 1 1 1 Radial spokehead-like protein DUF4216 PF13952.1 KOO26085.1 - 0.073 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4216) ABC_tran PF00005.22 KOO26086.1 - 4.3e-29 101.5 0.0 8.2e-20 71.5 0.0 3.0 3 0 0 3 3 3 2 ABC transporter ABC_tran_2 PF12848.2 KOO26086.1 - 2e-16 59.5 3.4 5.9e-16 58.0 0.0 2.5 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.1 KOO26086.1 - 1.8e-12 47.8 0.0 0.001 19.0 0.0 3.2 3 0 0 3 3 3 3 AAA domain AAA_29 PF13555.1 KOO26086.1 - 1.6e-08 33.8 0.0 0.0079 15.6 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.14 KOO26086.1 - 2.7e-08 33.2 0.0 0.0012 18.1 0.0 3.2 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 KOO26086.1 - 1.4e-06 28.8 0.1 0.11 12.7 0.0 3.0 3 0 0 3 3 3 2 AAA domain Miro PF08477.8 KOO26086.1 - 2.1e-06 28.2 0.0 0.0096 16.4 0.0 2.8 2 0 0 2 2 2 2 Miro-like protein AAA_25 PF13481.1 KOO26086.1 - 1.7e-05 24.3 0.0 0.16 11.3 0.0 2.7 2 1 0 2 2 2 2 AAA domain NACHT PF05729.7 KOO26086.1 - 5.5e-05 22.8 0.0 0.19 11.4 0.0 2.7 2 1 0 2 2 2 2 NACHT domain AAA_16 PF13191.1 KOO26086.1 - 6.3e-05 23.0 0.6 0.29 11.1 0.0 2.8 3 0 0 3 3 3 2 AAA ATPase domain AAA_17 PF13207.1 KOO26086.1 - 8e-05 23.4 0.1 0.98 10.2 0.0 3.1 4 0 0 4 4 2 2 AAA domain AAA_22 PF13401.1 KOO26086.1 - 0.00031 20.8 0.0 0.79 9.8 0.0 3.1 2 1 0 2 2 2 2 AAA domain AAA PF00004.24 KOO26086.1 - 0.00035 20.7 0.0 0.48 10.6 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 KOO26086.1 - 0.0019 18.2 0.0 1.1 9.2 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.1 KOO26086.1 - 0.0023 17.0 0.0 1 8.3 0.0 2.9 3 0 0 3 3 3 1 AAA ATPase domain DAP3 PF10236.4 KOO26086.1 - 0.0024 16.8 0.7 0.16 10.9 0.0 2.5 3 0 0 3 3 2 1 Mitochondrial ribosomal death-associated protein 3 Dynamin_N PF00350.18 KOO26086.1 - 0.0035 17.1 0.0 0.18 11.6 0.0 2.9 3 0 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.18 KOO26086.1 - 0.0035 17.2 0.0 4.3 7.3 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 KOO26086.1 - 0.0056 15.8 0.0 1.5 8.0 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 MobB PF03205.9 KOO26086.1 - 0.012 15.3 0.1 1.8 8.2 0.0 2.9 3 0 0 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 KOO26086.1 - 0.016 15.1 0.0 0.75 9.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 KOO26086.1 - 0.016 14.8 0.0 3.2 7.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Arch_ATPase PF01637.13 KOO26086.1 - 0.019 14.6 0.0 6.8 6.3 0.0 3.0 3 0 0 3 3 3 0 Archaeal ATPase AAA_10 PF12846.2 KOO26086.1 - 0.027 13.8 0.0 4.3 6.6 0.0 2.4 2 0 0 2 2 2 0 AAA-like domain AAA_14 PF13173.1 KOO26086.1 - 0.036 13.9 0.0 1.3 8.9 0.0 2.6 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.17 KOO26086.1 - 0.054 13.6 0.0 2.9 8.0 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA_19 PF13245.1 KOO26086.1 - 0.069 12.9 0.0 17 5.2 0.0 2.6 2 0 0 2 2 2 0 Part of AAA domain NB-ARC PF00931.17 KOO26086.1 - 0.072 11.9 0.0 2 7.2 0.0 2.7 2 1 0 3 3 3 0 NB-ARC domain AAA_18 PF13238.1 KOO26086.1 - 0.09 13.0 0.4 15 5.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain DnaJ PF00226.26 KOO26087.1 - 3.5e-13 49.0 0.0 7.2e-13 48.0 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain HSP70 PF00012.15 KOO26087.1 - 0.86 7.4 8.2 1.4 6.7 5.7 1.3 1 0 0 1 1 1 0 Hsp70 protein EF-hand_1 PF00036.27 KOO26088.1 - 0.00055 19.0 0.0 0.051 12.9 0.0 3.0 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.1 KOO26088.1 - 0.00069 19.7 0.4 0.0037 17.3 0.2 2.1 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO26088.1 - 0.0016 18.1 0.2 0.01 15.6 0.0 2.4 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.1 KOO26088.1 - 0.0026 17.3 0.4 0.29 10.7 0.0 2.7 3 0 0 3 3 3 1 EF-hand domain pair DUF4404 PF14357.1 KOO26088.1 - 0.098 13.0 0.6 1.2 9.5 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) His_Phos_1 PF00300.17 KOO26089.1 - 1.8e-15 57.3 0.0 6e-15 55.6 0.0 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) C2 PF00168.25 KOO26089.1 - 4.4e-06 26.4 0.0 8.2e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 C2 domain FIST PF08495.5 KOO26089.1 - 0.049 12.7 0.1 0.084 12.0 0.1 1.4 1 0 0 1 1 1 0 FIST N domain TauD PF02668.11 KOO26090.1 - 1.1e-36 126.8 0.0 1.5e-36 126.4 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.5 KOO26090.1 - 0.008 15.1 0.0 0.013 14.4 0.0 1.2 1 0 0 1 1 1 1 CsiD 2OG-FeII_Oxy_3 PF13640.1 KOO26090.1 - 0.13 12.7 0.0 0.33 11.4 0.0 1.7 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Glyco_hydro_20 PF00728.17 KOO26091.1 - 6.2e-78 262.4 0.7 1.1e-77 261.5 0.5 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Pyrophosphatase PF00719.14 KOO26091.1 - 1.4e-46 157.7 0.0 2.6e-46 156.9 0.0 1.4 1 0 0 1 1 1 1 Inorganic pyrophosphatase Glycohydro_20b2 PF14845.1 KOO26091.1 - 2.4e-18 67.0 0.0 5.8e-18 65.7 0.0 1.7 2 0 0 2 2 2 1 beta-acetyl hexosaminidase like Fasciclin PF02469.17 KOO26094.1 - 2.2e-09 37.3 0.0 4.3e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Fasciclin domain LRR_6 PF13516.1 KOO26095.1 - 1.5e-10 40.0 6.8 0.4 10.8 0.0 8.4 9 0 0 9 9 9 3 Leucine Rich repeat Skp1 PF01466.14 KOO26095.1 - 3.8e-06 26.8 0.0 1e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 Skp1 family, dimerisation domain LRR_1 PF00560.28 KOO26095.1 - 0.0008 19.1 0.0 28 5.2 0.0 5.7 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_4 PF12799.2 KOO26095.1 - 0.0069 15.9 0.3 6.7 6.4 0.0 4.2 4 0 0 4 4 4 1 Leucine Rich repeats (2 copies) Cupin_2 PF07883.6 KOO26096.1 - 6e-07 28.8 1.0 0.0024 17.3 0.5 2.6 2 1 0 2 2 2 2 Cupin domain Cupin_1 PF00190.17 KOO26096.1 - 0.0099 15.3 0.0 0.083 12.3 0.0 2.3 1 1 0 1 1 1 1 Cupin AraC_binding PF02311.14 KOO26096.1 - 0.029 14.0 0.2 6.1 6.5 0.0 3.1 3 0 0 3 3 3 0 AraC-like ligand binding domain Cupin_3 PF05899.7 KOO26096.1 - 0.044 13.1 0.3 0.33 10.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF861) MFS_1 PF07690.11 KOO26098.1 - 5.5e-25 87.8 27.6 5.5e-25 87.8 19.1 2.5 1 1 1 2 2 2 1 Major Facilitator Superfamily Pkinase PF00069.20 KOO26100.1 - 5.5e-34 117.4 0.0 8.2e-34 116.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO26100.1 - 2.8e-14 52.8 0.0 2.2e-12 46.6 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase ANTH PF07651.11 KOO26100.1 - 2.9e-05 22.9 0.5 5e-05 22.1 0.3 1.4 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.15 KOO26100.1 - 0.00069 19.4 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 ENTH domain Kinase-like PF14531.1 KOO26100.1 - 0.0022 16.9 0.0 0.0036 16.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO26100.1 - 0.0029 17.3 1.2 0.012 15.3 0.0 2.5 2 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 KOO26100.1 - 0.0033 17.0 0.0 0.0056 16.2 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Cupin_8 PF13621.1 KOO26101.1 - 1.3e-07 31.3 0.1 6.1e-05 22.6 0.0 2.2 2 0 0 2 2 2 2 Cupin-like domain JmjC PF02373.17 KOO26101.1 - 0.00011 22.4 0.1 0.00027 21.1 0.1 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_4 PF08007.7 KOO26101.1 - 0.061 12.5 0.2 0.097 11.8 0.1 1.2 1 0 0 1 1 1 0 Cupin superfamily protein DnaJ PF00226.26 KOO26102.1 - 1.3e-18 66.4 0.0 2.3e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain CIA30 PF08547.7 KOO26102.1 - 0.012 15.4 0.0 2 8.2 0.0 2.6 2 0 0 2 2 2 0 Complex I intermediate-associated protein 30 (CIA30) VCBS PF13517.1 KOO26104.1 - 4.5e-27 94.1 13.2 1.6e-07 31.5 0.1 6.2 6 1 1 7 7 7 5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella UnbV_ASPIC PF07593.7 KOO26104.1 - 8e-20 70.3 0.0 1.5e-19 69.4 0.0 1.5 1 0 0 1 1 1 1 ASPIC and UnbV FG-GAP PF01839.18 KOO26104.1 - 7.4e-16 57.3 19.7 0.0018 17.9 0.0 5.9 6 0 0 6 6 6 5 FG-GAP repeat DUF1214 PF06742.6 KOO26104.1 - 0.063 13.7 0.1 5.4 7.5 0.0 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF1214) EF-hand_1 PF00036.27 KOO26104.1 - 0.37 10.2 7.5 39 3.8 0.0 5.0 5 0 0 5 5 5 0 EF hand ATP-synt_10 PF05176.9 KOO26105.1 - 3.1e-17 62.6 0.0 3.7e-17 62.4 0.0 1.0 1 0 0 1 1 1 1 ATP10 protein RapA_C PF12137.3 KOO26105.1 - 0.094 11.5 2.6 0.048 12.4 0.4 1.4 2 0 0 2 2 2 0 RNA polymerase recycling family C-terminal Rotamase PF00639.16 KOO26106.1 - 2.6e-15 56.9 0.0 1.2e-14 54.7 0.0 1.8 2 0 0 2 2 2 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 KOO26106.1 - 4.4e-09 36.6 0.0 6.1e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 KOO26106.1 - 5.6e-05 23.7 0.0 9.4e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Fe-S_biosyn PF01521.15 KOO26108.1 - 3.3e-16 59.1 0.0 4.3e-16 58.8 0.0 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis ABC_tran PF00005.22 KOO26109.1 - 4.2e-31 108.0 0.0 1.5e-30 106.3 0.0 2.0 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 KOO26109.1 - 2e-06 27.1 0.0 1e-05 24.8 0.1 1.6 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 KOO26109.1 - 0.00056 19.9 0.0 0.046 13.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.1 KOO26109.1 - 0.00086 19.1 0.3 0.0054 16.6 0.2 2.2 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit DUF2407 PF10302.4 KOO26109.1 - 0.016 15.3 0.8 8.2 6.6 0.1 3.6 4 0 0 4 4 4 0 DUF2407 ubiquitin-like domain ABC_ATPase PF09818.4 KOO26109.1 - 0.021 13.4 0.0 0.044 12.3 0.0 1.5 1 0 0 1 1 1 0 Predicted ATPase of the ABC class Zeta_toxin PF06414.7 KOO26109.1 - 0.027 13.5 0.0 0.089 11.8 0.0 1.8 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.1 KOO26109.1 - 0.049 13.7 2.5 0.29 11.2 0.3 3.0 2 1 0 2 2 2 0 AAA domain AAA_17 PF13207.1 KOO26109.1 - 0.052 14.3 0.0 0.21 12.4 0.0 2.1 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.10 KOO26109.1 - 0.14 10.7 0.0 0.27 9.8 0.0 1.3 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein ABC1 PF03109.11 KOO26110.1 - 1.9e-18 66.5 0.0 4.3e-18 65.4 0.0 1.7 1 0 0 1 1 1 1 ABC1 family His_Phos_1 PF00300.17 KOO26111.1 - 6.9e-20 71.7 0.0 1.1e-19 71.0 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DAO PF01266.19 KOO26111.1 - 0.077 11.8 0.0 0.1 11.4 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase DUF4336 PF14234.1 KOO26112.1 - 1.7e-54 184.9 0.0 3.1e-53 180.8 0.0 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4336) Tegument_dsDNA PF12818.2 KOO26113.1 - 0.0081 15.0 0.2 0.2 10.5 0.0 2.3 2 0 0 2 2 2 2 dsDNA viral tegument protein PfkB PF00294.19 KOO26114.1 - 3.7e-09 36.1 0.0 4.6e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Dus PF01207.12 KOO26115.1 - 3.7e-59 200.0 0.5 6.2e-59 199.3 0.3 1.3 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Oxidored_FMN PF00724.15 KOO26115.1 - 0.0033 16.4 0.0 0.0051 15.8 0.0 1.2 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family His_biosynth PF00977.16 KOO26115.1 - 0.0061 15.8 0.1 0.0092 15.2 0.0 1.2 1 0 0 1 1 1 1 Histidine biosynthesis protein ThiG PF05690.9 KOO26115.1 - 0.007 15.4 0.8 0.011 14.8 0.5 1.2 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG NMO PF03060.10 KOO26115.1 - 0.022 13.9 1.1 0.038 13.1 0.7 1.3 1 0 0 1 1 1 0 Nitronate monooxygenase SOR_SNZ PF01680.12 KOO26115.1 - 0.3 10.6 3.0 1.5 8.4 0.8 2.2 1 1 1 2 2 2 0 SOR/SNZ family Nuc_sug_transp PF04142.10 KOO26117.1 - 2.3e-75 252.8 7.3 3.1e-75 252.4 5.0 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter EmrE PF13536.1 KOO26117.1 - 4.2e-05 23.7 8.5 4.2e-05 23.7 5.9 2.9 2 1 1 3 3 3 1 Multidrug resistance efflux transporter UAA PF08449.6 KOO26117.1 - 0.00049 19.1 0.8 0.00049 19.1 0.5 1.6 2 0 0 2 2 2 1 UAA transporter family EamA PF00892.15 KOO26117.1 - 0.00073 19.5 6.2 0.00073 19.5 4.3 2.8 2 1 1 3 3 3 1 EamA-like transporter family EF-hand_7 PF13499.1 KOO26118.1 - 2.6e-17 62.7 0.2 6.1e-17 61.5 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO26118.1 - 1.6e-15 55.1 0.8 1.9e-09 36.1 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO26118.1 - 3e-13 49.1 1.0 1.3e-11 43.9 0.0 2.8 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO26118.1 - 1.4e-10 40.1 0.2 3.9e-08 32.5 0.1 2.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.1 KOO26118.1 - 3e-08 32.6 0.2 1.4e-06 27.4 0.0 2.5 2 0 0 2 2 2 1 EF hand SPARC_Ca_bdg PF10591.4 KOO26118.1 - 0.00087 19.2 0.0 0.0016 18.4 0.0 1.4 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EFhand_Ca_insen PF08726.5 KOO26118.1 - 0.1 12.5 0.1 0.28 11.1 0.0 1.8 1 0 0 1 1 1 0 Ca2+ insensitive EF hand EF-hand_4 PF12763.2 KOO26118.1 - 0.2 11.3 0.1 0.46 10.2 0.0 1.5 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand ShK PF01549.19 KOO26119.1 - 1.9e-13 50.4 31.7 3.1e-07 30.6 1.5 4.7 4 1 0 4 4 4 4 ShK domain-like 2OG-FeII_Oxy_3 PF13640.1 KOO26119.1 - 9.2e-09 35.7 0.0 2.3e-08 34.4 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO26119.1 - 9.4e-08 32.2 0.0 2e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-CCCH PF00642.19 KOO26119.1 - 0.043 13.4 1.8 14 5.4 0.0 3.5 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) 2OG-FeII_Oxy_4 PF13661.1 KOO26119.1 - 0.066 12.8 0.1 0.17 11.5 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Filamin PF00630.14 KOO26120.1 - 5.5e-06 26.8 0.0 6.3e-05 23.4 0.0 2.1 2 0 0 2 2 2 1 Filamin/ABP280 repeat Ank_2 PF12796.2 KOO26121.1 - 1.2e-20 73.6 1.2 2.9e-09 37.1 0.1 3.3 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO26121.1 - 3e-15 55.1 0.2 2.3e-07 30.2 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOO26121.1 - 4.1e-13 49.4 0.6 6.8e-06 26.4 0.0 4.6 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO26121.1 - 4e-12 45.9 0.2 0.00094 19.3 0.0 4.9 4 1 0 4 4 4 3 Ankyrin repeats (many copies) EF-hand_1 PF00036.27 KOO26121.1 - 1.9e-11 42.3 2.7 0.00011 21.2 0.1 3.0 2 0 0 2 2 2 2 EF hand Ank_3 PF13606.1 KOO26121.1 - 5.4e-10 38.5 0.2 0.00061 19.7 0.0 5.1 5 1 0 5 5 4 2 Ankyrin repeat EF-hand_7 PF13499.1 KOO26121.1 - 2.1e-08 34.1 0.6 4.6e-08 33.0 0.4 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO26121.1 - 1.1e-05 24.8 5.4 0.0077 15.8 0.7 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO26121.1 - 2.1e-05 24.0 0.3 0.093 12.6 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 KOO26121.1 - 0.11 12.2 0.3 0.38 10.5 0.2 1.8 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Inhibitor_I34 PF10466.4 KOO26121.1 - 0.54 10.3 4.2 12 6.0 0.0 3.7 4 1 1 5 5 5 0 Saccharopepsin inhibitor I34 EF-hand_5 PF13202.1 KOO26121.1 - 0.65 9.4 0.0 0.65 9.4 0.0 3.3 3 1 0 3 3 3 0 EF hand LVIVD PF08309.6 KOO26123.1 - 1.9e-50 167.5 49.1 2e-11 42.6 2.1 6.3 5 1 1 6 6 6 6 LVIVD repeat Beta_propel PF09826.4 KOO26123.1 - 2.3e-05 22.9 0.0 2.5 6.3 0.0 4.1 4 0 0 4 4 4 3 Beta propeller domain VHL PF01847.11 KOO26123.1 - 0.013 15.1 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 von Hippel-Lindau disease tumour suppressor protein DUF4560 PF15118.1 KOO26123.1 - 0.019 14.7 1.8 6.7 6.6 0.0 3.6 5 0 0 5 5 5 0 Domain of unknown function (DUF4560) Chitin_bind_4 PF00379.18 KOO26123.1 - 0.027 14.7 17.4 18 5.6 0.0 6.3 6 0 0 6 6 6 0 Insect cuticle protein PQQ_3 PF13570.1 KOO26123.1 - 5.5 7.3 32.2 4.1 7.8 0.0 6.6 4 1 0 4 4 4 0 PQQ-like domain Ufm1 PF03671.9 KOO26124.1 - 9.4e-43 143.8 0.1 1.2e-42 143.4 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein Peptidase_S13 PF02113.10 KOO26124.1 - 0.094 11.2 0.0 0.1 11.0 0.0 1.0 1 0 0 1 1 1 0 D-Ala-D-Ala carboxypeptidase 3 (S13) family TIG PF01833.19 KOO26125.1 - 4.9e-06 26.4 0.0 0.074 13.0 0.0 3.4 2 1 0 2 2 2 2 IPT/TIG domain TTL PF03133.10 KOO26126.1 - 1.1e-19 70.4 0.0 1.4e-18 66.8 0.0 2.2 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family LRR_6 PF13516.1 KOO26126.1 - 2.1e-11 42.6 13.7 0.033 14.2 0.0 7.1 7 0 0 7 7 7 4 Leucine Rich repeat ATPgrasp_YheCD PF14398.1 KOO26126.1 - 9.9e-05 21.2 0.0 0.0004 19.2 0.0 2.0 2 0 0 2 2 2 1 YheC/D like ATP-grasp LRR_4 PF12799.2 KOO26126.1 - 0.019 14.5 4.3 0.61 9.7 0.0 3.9 3 2 1 4 4 4 0 Leucine Rich repeats (2 copies) C2 PF00168.25 KOO26127.1 - 3.8e-18 65.1 0.0 5.7e-18 64.5 0.0 1.3 1 0 0 1 1 1 1 C2 domain PAE PF03283.8 KOO26128.1 - 6.7e-12 44.7 0.0 8.8e-12 44.3 0.0 1.2 1 0 0 1 1 1 1 Pectinacetylesterase UPF0150 PF03681.10 KOO26128.1 - 0.13 11.8 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0150) PAS_2 PF08446.6 KOO26129.1 - 0.022 15.2 0.9 0.03 14.7 0.6 1.3 1 0 0 1 1 1 0 PAS fold DIT1_PvcA PF05141.7 KOO26129.1 - 0.059 12.6 1.9 0.063 12.5 1.3 1.0 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein Apc4 PF12896.2 KOO26129.1 - 0.076 12.3 1.0 0.085 12.1 0.7 1.1 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 4 Pex19 PF04614.7 KOO26129.1 - 0.079 12.5 4.6 0.086 12.4 3.2 1.0 1 0 0 1 1 1 0 Pex19 protein family Apolipoprotein PF01442.13 KOO26129.1 - 0.1 12.0 5.4 0.34 10.3 3.8 1.8 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF4456 PF14644.1 KOO26129.1 - 0.12 11.5 5.1 0.11 11.7 1.3 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4456) Phage_GP20 PF06810.6 KOO26129.1 - 0.12 11.7 2.1 0.13 11.6 1.5 1.1 1 0 0 1 1 1 0 Phage minor structural protein GP20 DUF4618 PF15397.1 KOO26129.1 - 0.14 11.5 3.1 0.16 11.2 2.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) OmpH PF03938.9 KOO26129.1 - 0.55 10.1 8.3 0.63 9.9 5.8 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF288 PF03385.12 KOO26130.1 - 1e-11 43.9 0.0 1.5e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF288 PKD_channel PF08016.7 KOO26131.1 - 8.5e-46 156.2 6.8 2.1e-37 128.6 4.1 2.2 1 1 1 2 2 2 2 Polycystin cation channel Tim44 PF04280.10 KOO26131.1 - 7.9e-14 51.8 0.0 1.6e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 Tim44-like domain Ion_trans PF00520.26 KOO26131.1 - 3.9e-07 29.5 12.8 7.6e-07 28.5 8.9 1.4 1 0 0 1 1 1 1 Ion transport protein YfhO PF09586.5 KOO26131.1 - 0.067 11.2 0.8 0.11 10.5 0.5 1.3 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF1379 PF07126.7 KOO26131.1 - 0.15 11.3 0.2 0.29 10.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1379) BPL_N PF09825.4 KOO26133.1 - 8.7e-09 34.6 1.7 1.4e-05 24.0 0.5 2.1 2 0 0 2 2 2 2 Biotin-protein ligase, N terminal DJ-1_PfpI PF01965.19 KOO26133.1 - 0.0058 16.0 0.5 0.0098 15.3 0.4 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family ThuA PF06283.6 KOO26133.1 - 0.01 15.5 0.0 0.023 14.4 0.0 1.5 2 0 0 2 2 2 0 Trehalose utilisation Cpn60_TCP1 PF00118.19 KOO26134.1 - 6.4e-144 480.1 1.0 7.4e-144 479.9 0.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family XPG_I PF00867.13 KOO26135.1 - 5.9e-25 87.1 0.1 1.3e-24 86.0 0.1 1.7 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 KOO26135.1 - 1.3e-23 83.1 0.0 2.5e-23 82.2 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain UPF0029 PF01205.14 KOO26135.1 - 8e-18 64.1 0.9 2.5e-17 62.5 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized protein family UPF0029 Atrophin-1 PF03154.10 KOO26135.1 - 0.00091 17.5 1.8 0.00091 17.5 1.3 2.6 2 0 0 2 2 2 1 Atrophin-1 family DEAD PF00270.24 KOO26137.1 - 6.6e-43 146.1 0.0 2.6e-42 144.1 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO26137.1 - 5e-28 96.7 0.0 1.5e-27 95.2 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO26137.1 - 0.00022 21.1 0.0 0.0017 18.2 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 KOO26137.1 - 0.00041 19.2 0.0 0.00049 19.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Penicillinase_R PF03965.11 KOO26137.1 - 0.012 15.6 0.0 0.032 14.3 0.0 1.6 1 0 0 1 1 1 0 Penicillinase repressor Toxin-deaminase PF14424.1 KOO26139.1 - 0.0063 16.4 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 The BURPS668_1122 family of deaminases FATC PF02260.15 KOO26141.1 - 4.6e-11 41.9 0.1 8.8e-11 41.0 0.0 1.5 1 0 0 1 1 1 1 FATC domain ASL_C PF08328.6 KOO26142.1 - 2e-50 169.4 0.0 3.4e-50 168.7 0.0 1.4 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminal Lyase_1 PF00206.15 KOO26142.1 - 1.5e-29 103.2 0.0 7.5e-20 71.3 0.0 2.2 2 0 0 2 2 2 2 Lyase zf-B_box PF00643.19 KOO26143.1 - 1e-08 34.8 6.8 1e-08 34.8 4.7 3.6 3 2 0 3 3 3 1 B-box zinc finger zf-RING_2 PF13639.1 KOO26143.1 - 3.7e-07 29.8 12.4 3.7e-07 29.8 8.6 2.4 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 KOO26143.1 - 3.4e-06 26.6 11.2 3.4e-06 26.6 7.7 2.7 2 2 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 KOO26143.1 - 9.3e-06 25.4 4.6 9.3e-06 25.4 3.2 3.0 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 KOO26143.1 - 6.4e-05 22.5 1.3 6.4e-05 22.5 0.9 2.6 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.20 KOO26143.1 - 0.00015 21.3 13.2 0.00015 21.3 9.1 2.8 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO26143.1 - 0.0012 18.8 15.0 0.0012 18.8 10.4 2.9 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.1 KOO26143.1 - 0.0018 18.0 2.9 0.0018 18.0 2.0 2.2 3 0 0 3 3 3 1 zf-RING of BARD1-type protein zf-Nse PF11789.3 KOO26143.1 - 1.1 8.7 10.0 4.1 7.0 6.9 1.9 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DUF3323 PF11796.3 KOO26143.1 - 4.7 6.4 10.3 14 4.9 3.7 2.2 1 1 1 2 2 2 0 Protein of unknown function N-terminus (DUF3323) DUF1680 PF07944.7 KOO26144.1 - 1.7e-92 310.3 0.0 2.1e-92 310.0 0.0 1.1 1 0 0 1 1 1 1 Putative glycosyl hydrolase of unknown function (DUF1680) Peptidase_M17_N PF02789.12 KOO26144.1 - 2.6e-05 23.9 0.2 0.085 12.6 0.0 2.4 2 0 0 2 2 2 2 Cytosol aminopeptidase family, N-terminal domain TPT PF03151.11 KOO26145.1 - 6.7e-18 64.7 4.8 6.7e-18 64.7 3.3 3.1 3 0 0 3 3 3 2 Triose-phosphate Transporter family EamA PF00892.15 KOO26145.1 - 1.5e-08 34.7 11.4 4.7e-08 33.1 3.1 3.3 4 1 0 4 4 4 2 EamA-like transporter family UAA PF08449.6 KOO26145.1 - 5.6e-07 28.7 6.1 1e-06 27.9 4.2 1.3 1 0 0 1 1 1 1 UAA transporter family Borrelia_P83 PF05262.6 KOO26146.1 - 2.7 6.1 19.4 4.1 5.5 13.4 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Oxysterol_BP PF01237.13 KOO26146.1 - 3.1 6.2 7.5 5.6 5.3 5.2 1.4 1 0 0 1 1 1 0 Oxysterol-binding protein WD40 PF00400.27 KOO26147.1 - 5.8e-10 38.6 2.7 5.7e-06 26.0 0.0 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat Nucleoporin_N PF08801.6 KOO26148.1 - 0.023 13.4 0.5 0.17 10.6 0.2 2.2 1 1 1 2 2 2 0 Nup133 N terminal like DUF500 PF04366.7 KOO26149.1 - 1.5e-21 76.1 0.1 5.2e-21 74.3 0.0 2.0 1 0 0 1 1 1 1 Family of unknown function (DUF500) FH2 PF02181.18 KOO26151.1 - 3.6e-37 128.1 0.0 3.1e-33 115.1 0.0 2.1 2 0 0 2 2 2 2 Formin Homology 2 Domain Spidroin_MaSp PF11260.3 KOO26151.1 - 0.11 12.5 3.4 0.88 9.6 0.1 3.0 3 0 0 3 3 3 0 Major ampullate spidroin 1 and 2 Jiraiya PF15038.1 KOO26152.1 - 0.0016 17.9 5.0 0.0025 17.2 3.5 1.3 1 0 0 1 1 1 1 Jiraiya Strabismus PF06638.6 KOO26152.1 - 0.011 14.0 1.4 0.015 13.6 1.0 1.1 1 0 0 1 1 1 0 Strabismus protein Orai-1 PF07856.7 KOO26152.1 - 0.11 12.0 5.9 0.26 10.8 0.9 2.5 3 0 0 3 3 3 0 Mediator of CRAC channel activity Pex24p PF06398.6 KOO26152.1 - 0.24 10.1 3.0 0.12 11.1 0.1 1.8 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin Podoplanin PF05808.6 KOO26152.1 - 0.91 9.0 4.0 1.2 8.6 0.0 2.3 2 0 0 2 2 2 0 Podoplanin TPR_12 PF13424.1 KOO26153.1 - 1.9e-10 40.5 6.7 2.8e-10 39.9 1.4 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO26153.1 - 9.6e-09 34.3 3.0 0.002 17.7 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.1 KOO26153.1 - 1.6e-08 34.0 2.3 3.4e-08 32.9 0.9 2.0 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.12 KOO26153.1 - 1.2e-06 28.0 5.6 0.015 15.1 0.8 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO26153.1 - 1.2e-06 27.8 3.3 0.00095 18.6 0.4 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.1 KOO26153.1 - 1.6e-06 27.8 1.4 0.018 14.9 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO26153.1 - 7e-06 25.4 0.6 0.00017 21.0 0.3 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO26153.1 - 7.5e-06 26.1 1.7 0.016 15.5 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat DUF2225 PF09986.4 KOO26153.1 - 0.00026 20.5 1.0 0.0005 19.5 0.7 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_6 PF13174.1 KOO26153.1 - 0.0042 17.4 0.9 0.11 12.9 0.1 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO26153.1 - 0.0067 16.9 7.1 1.8 9.3 0.2 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat Apc3 PF12895.2 KOO26153.1 - 0.0079 16.3 4.1 0.017 15.2 1.2 2.4 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF3366 PF11846.3 KOO26153.1 - 0.042 13.7 0.2 0.1 12.4 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3366) TPR_16 PF13432.1 KOO26153.1 - 0.08 13.6 9.5 0.12 13.0 0.5 3.9 2 2 1 3 3 3 0 Tetratricopeptide repeat Cofilin_ADF PF00241.15 KOO26155.1 - 2.5e-05 24.1 0.1 4.1e-05 23.4 0.1 1.5 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Acetyltransf_1 PF00583.19 KOO26157.1 - 1.5e-15 56.9 0.0 2.7e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 KOO26157.1 - 6.2e-09 35.8 0.1 1.2e-08 35.0 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 KOO26157.1 - 0.00013 21.9 0.0 0.00016 21.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 KOO26157.1 - 0.00058 19.9 0.0 0.00076 19.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 KOO26157.1 - 0.00075 19.3 0.0 0.0018 18.0 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 KOO26157.1 - 0.0017 18.0 0.0 0.0026 17.4 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.1 KOO26157.1 - 0.0099 15.7 0.0 0.012 15.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 KOO26157.1 - 0.028 14.5 0.0 0.032 14.4 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Metallophos PF00149.23 KOO26158.1 - 2e-15 56.7 0.0 4.7e-15 55.5 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KOO26158.1 - 5.5e-05 23.0 0.0 0.0001 22.1 0.0 1.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Myb_DNA-binding PF00249.26 KOO26159.1 - 3.3e-15 55.8 6.4 3.7e-11 42.8 0.1 2.9 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO26159.1 - 1.5e-11 44.2 0.5 3.1e-08 33.5 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_2 PF08914.6 KOO26159.1 - 0.002 17.8 0.0 2 8.2 0.0 2.5 2 0 0 2 2 2 2 Rap1 Myb domain Atg14 PF10186.4 KOO26160.1 - 4.7 6.0 18.9 6.2 5.6 13.1 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 PhyH PF05721.8 KOO26161.1 - 2.5e-08 34.1 0.0 7.5e-08 32.6 0.0 1.8 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Glyco_trans_1_4 PF13692.1 KOO26162.1 - 0.0061 16.7 0.1 0.0074 16.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Dimer_Tnp_hAT PF05699.9 KOO26163.1 - 4e-06 26.3 0.1 5.7e-06 25.8 0.1 1.3 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region ArfGap PF01412.13 KOO26164.1 - 1.2e-32 112.0 0.0 2e-32 111.4 0.0 1.2 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.24 KOO26164.1 - 2e-07 31.1 0.0 6e-07 29.6 0.0 1.8 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 KOO26164.1 - 0.0063 16.7 0.5 0.067 13.4 0.3 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain zf-C3HC4_3 PF13920.1 KOO26164.1 - 0.12 12.0 0.2 0.2 11.3 0.1 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.19 KOO26164.1 - 0.23 11.3 1.0 1.2 9.0 0.3 2.3 2 1 0 2 2 2 0 B-box zinc finger AAA_34 PF13872.1 KOO26165.1 - 5.2e-86 288.1 0.0 5.9e-86 287.9 0.0 1.0 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 DEAD PF00270.24 KOO26165.1 - 0.045 13.2 0.0 0.069 12.6 0.0 1.4 1 1 0 1 1 1 0 DEAD/DEAH box helicase Cys_rich_VLP PF14194.1 KOO26165.1 - 0.1 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Cysteine-rich VLP Chloroa_b-bind PF00504.16 KOO26166.1 - 2.7e-37 128.4 0.3 2.4e-24 86.3 0.1 1.4 1 1 1 2 2 2 2 Chlorophyll A-B binding protein Tic22 PF04278.7 KOO26168.1 - 1.3e-19 70.5 0.1 1.7e-19 70.1 0.1 1.1 1 0 0 1 1 1 1 Tic22-like family TPR_19 PF14559.1 KOO26169.1 - 0.021 15.1 1.7 0.044 14.1 1.2 1.6 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO26169.1 - 0.21 12.3 0.2 0.21 12.3 0.1 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat LRR_6 PF13516.1 KOO26170.1 - 9.1e-23 77.7 2.2 0.026 14.5 0.0 7.5 7 0 0 7 7 7 6 Leucine Rich repeat LRR_4 PF12799.2 KOO26170.1 - 5.9e-12 44.9 0.1 0.027 14.0 0.0 5.3 2 2 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO26170.1 - 2.3e-05 23.8 1.4 13 6.4 0.0 6.2 7 0 0 7 7 7 1 Leucine rich repeat LRR_1 PF00560.28 KOO26170.1 - 0.00079 19.1 1.7 11 6.4 0.0 5.2 5 2 1 6 6 6 1 Leucine Rich Repeat LRR_8 PF13855.1 KOO26170.1 - 0.008 15.9 4.4 4.4 7.1 0.1 4.9 3 2 0 3 3 3 2 Leucine rich repeat HCO3_cotransp PF00955.16 KOO26171.1 - 8.6e-40 136.8 0.1 1.2e-39 136.3 0.1 1.1 1 0 0 1 1 1 1 HCO3- transporter family DUF2935 PF11155.3 KOO26172.1 - 0.05 13.6 0.1 0.092 12.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) ALG3 PF05208.8 KOO26173.1 - 3.8e-114 381.7 2.2 5.4e-114 381.2 1.5 1.1 1 0 0 1 1 1 1 ALG3 protein Patatin PF01734.17 KOO26174.1 - 1.3e-07 31.8 1.5 0.0022 17.9 0.3 2.3 1 1 1 2 2 2 2 Patatin-like phospholipase DUF4266 PF14086.1 KOO26175.1 - 0.37 11.3 2.5 1.1 9.8 1.7 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4266) Thioredoxin PF00085.15 KOO26176.1 - 0.00037 20.1 0.0 0.00064 19.3 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Helicase_C_4 PF13871.1 KOO26177.1 - 2.4e-91 306.0 1.9 2.2e-77 260.2 1.2 2.3 1 1 1 2 2 2 2 Helicase_C-like Helicase_C PF00271.26 KOO26177.1 - 9.1e-05 22.2 0.2 0.00032 20.4 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SelR PF01641.13 KOO26178.1 - 8e-23 80.4 1.0 9.2e-23 80.2 0.7 1.0 1 0 0 1 1 1 1 SelR domain Yippee-Mis18 PF03226.9 KOO26178.1 - 0.12 12.3 3.3 0.8 9.7 2.3 2.0 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly MFS_1 PF07690.11 KOO26179.1 - 4.3e-05 22.3 45.1 0.00039 19.2 6.8 3.1 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KOO26179.1 - 0.0092 14.4 10.4 0.093 11.1 0.0 2.6 2 1 0 2 2 2 2 MFS/sugar transport protein AAA_34 PF13872.1 KOO26182.1 - 5.4e-05 22.1 0.0 8.1e-05 21.5 0.0 1.2 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 DUF1311 PF07007.7 KOO26182.1 - 0.0055 16.7 1.6 0.07 13.2 0.3 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1311) Josephin PF02099.12 KOO26183.1 - 4.1e-42 143.4 0.1 6e-42 142.9 0.1 1.2 1 0 0 1 1 1 1 Josephin UBX PF00789.15 KOO26183.1 - 4e-08 33.2 0.0 8.1e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 UBX domain UIM PF02809.15 KOO26183.1 - 0.16 11.6 3.0 0.46 10.2 2.1 1.8 1 0 0 1 1 1 0 Ubiquitin interaction motif Melibiase PF02065.13 KOO26184.1 - 0.00071 18.3 0.0 0.0015 17.3 0.0 1.4 1 0 0 1 1 1 1 Melibiase DEAD PF00270.24 KOO26185.1 - 1.9e-13 50.2 0.1 1.2e-11 44.4 0.1 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO26185.1 - 1.7e-09 37.3 0.1 9.2e-09 35.0 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_19 PF13245.1 KOO26185.1 - 2.2e-05 24.1 6.2 0.0005 19.7 0.2 3.5 4 0 0 4 4 3 1 Part of AAA domain Arch_ATPase PF01637.13 KOO26185.1 - 0.0001 22.1 0.0 0.00016 21.4 0.0 1.2 1 0 0 1 1 1 1 Archaeal ATPase ResIII PF04851.10 KOO26185.1 - 0.00069 19.5 0.0 0.0072 16.1 0.0 2.4 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_25 PF13481.1 KOO26185.1 - 0.0007 19.0 0.0 0.0017 17.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 KOO26185.1 - 0.00071 19.4 0.0 0.0031 17.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KOO26185.1 - 0.00093 19.3 0.2 0.0033 17.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.1 KOO26185.1 - 0.0017 17.9 0.1 0.0064 16.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 KOO26185.1 - 0.013 14.6 0.9 0.022 13.9 0.0 1.8 2 0 0 2 2 1 0 Protein of unknown function, DUF258 TrwB_AAD_bind PF10412.4 KOO26185.1 - 0.025 13.2 0.0 0.066 11.8 0.0 1.6 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_29 PF13555.1 KOO26185.1 - 0.028 13.9 0.0 0.062 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.22 KOO26185.1 - 0.028 14.7 0.0 0.07 13.4 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_11 PF13086.1 KOO26185.1 - 0.032 13.7 0.2 0.13 11.7 0.1 1.9 1 1 1 2 2 2 0 AAA domain PhoH PF02562.11 KOO26185.1 - 0.033 13.4 0.0 0.062 12.5 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein DAP3 PF10236.4 KOO26185.1 - 0.042 12.7 0.0 0.069 12.0 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 T2SE PF00437.15 KOO26185.1 - 0.055 12.3 0.0 0.1 11.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Viral_helicase1 PF01443.13 KOO26185.1 - 0.064 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.1 KOO26185.1 - 0.065 13.2 0.1 0.36 10.7 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.7 KOO26185.1 - 0.081 12.0 0.0 0.23 10.5 0.0 1.8 1 0 0 1 1 1 0 Zeta toxin FtsK_SpoIIIE PF01580.13 KOO26185.1 - 0.085 12.3 0.0 0.25 10.7 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family UvrD-helicase PF00580.16 KOO26185.1 - 0.1 11.8 0.1 0.16 11.2 0.1 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_23 PF13476.1 KOO26185.1 - 0.11 12.8 0.0 0.18 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF1098 PF06497.6 KOO26185.1 - 0.16 12.0 0.0 2.1 8.4 0.0 2.5 3 0 0 3 3 2 0 Protein of unknown function (DUF1098) WD40 PF00400.27 KOO26186.1 - 6e-52 171.7 15.1 1.9e-12 46.5 0.4 4.3 4 0 0 4 4 4 4 WD domain, G-beta repeat PD40 PF07676.7 KOO26186.1 - 6.7e-11 41.6 0.7 0.65 9.7 0.0 4.4 4 0 0 4 4 4 4 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOO26186.1 - 5.5e-06 26.2 0.0 0.00059 19.6 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.1 KOO26186.1 - 2.7e-05 23.8 0.1 0.35 10.6 0.0 3.7 1 1 3 4 4 4 3 Ciliary BBSome complex subunit 2, middle region Nbas_N PF15492.1 KOO26186.1 - 0.00025 20.2 1.2 3.2 6.7 0.0 3.5 1 1 3 4 4 4 3 Neuroblastoma-amplified sequence, N terminal Gmad1 PF10647.4 KOO26186.1 - 0.00033 20.1 0.1 0.042 13.2 0.0 3.3 2 1 0 2 2 2 1 Lipoprotein LpqB beta-propeller domain Dfp1_Him1_M PF08630.5 KOO26186.1 - 0.00071 19.3 3.1 2.8 7.7 0.0 3.4 3 1 0 3 3 3 2 Dfp1/Him1, central region DUF3312 PF11768.3 KOO26186.1 - 0.0019 16.5 0.0 0.54 8.4 0.0 2.5 1 1 2 3 3 3 3 Protein of unknown function (DUF3312) TFIIIC_delta PF12657.2 KOO26186.1 - 0.0029 17.3 0.4 0.18 11.4 0.1 2.7 1 1 1 2 2 2 2 Transcription factor IIIC subunit delta N-term DUF1513 PF07433.6 KOO26186.1 - 0.01 14.7 0.0 0.51 9.1 0.0 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1513) MMS1_N PF10433.4 KOO26186.1 - 0.014 13.5 0.1 2.8 5.9 0.0 2.3 1 1 1 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term UN_NPL4 PF11543.3 KOO26186.1 - 0.026 14.8 1.7 37 4.6 0.0 4.1 3 1 1 4 4 4 0 Nuclear pore localisation protein NPL4 Proteasome_A_N PF10584.4 KOO26186.1 - 0.078 12.3 5.8 15 4.9 0.0 4.1 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature CppA_C PF14507.1 KOO26186.1 - 0.089 12.9 0.3 4.7 7.4 0.0 2.5 1 1 1 2 2 2 0 CppA C-terminal Gp_dh_C PF02800.15 KOO26187.1 - 6.8e-72 240.0 0.0 1e-71 239.4 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 KOO26187.1 - 1e-51 174.8 0.7 1.6e-51 174.2 0.2 1.5 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain ADH_zinc_N PF00107.21 KOO26187.1 - 0.011 15.3 0.0 0.021 14.3 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase zf-trcl PF13451.1 KOO26188.1 - 0.02 14.5 0.8 5.6 6.6 0.1 2.4 2 0 0 2 2 2 0 Probable zinc-binding domain zinc_ribbon_5 PF13719.1 KOO26188.1 - 0.096 12.2 0.2 2.5 7.7 0.0 2.5 2 0 0 2 2 2 0 zinc-ribbon domain TFIIS_C PF01096.13 KOO26188.1 - 0.72 9.5 3.8 14 5.4 0.0 2.5 3 0 0 3 3 3 0 Transcription factor S-II (TFIIS) NAGLU PF05089.7 KOO26189.1 - 4.4e-79 265.6 0.6 6.3e-79 265.1 0.4 1.2 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.2 KOO26189.1 - 1.9e-41 142.2 0.1 2.8e-41 141.6 0.1 1.1 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU_N PF12971.2 KOO26189.1 - 4e-15 55.2 0.0 1.7e-14 53.2 0.0 2.1 2 0 0 2 2 2 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain Glyco_transf_29 PF00777.13 KOO26190.1 - 6.2e-27 94.4 0.0 9.3e-25 87.2 0.0 2.1 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) FancD2 PF14631.1 KOO26192.1 - 1.9e-120 403.1 0.0 2.5e-77 260.2 0.0 3.1 3 0 0 3 3 3 3 Fanconi anaemia protein FancD2 nuclease Ion_trans_2 PF07885.11 KOO26194.1 - 6.4e-15 54.6 1.5 1.5e-14 53.4 1.0 1.5 1 0 0 1 1 1 1 Ion channel EF-hand_5 PF13202.1 KOO26194.1 - 0.054 12.8 0.2 0.13 11.6 0.2 1.7 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.1 KOO26194.1 - 0.14 12.1 0.1 0.52 10.3 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain EF-hand_6 PF13405.1 KOO26196.1 - 5e-28 94.4 22.2 5.6e-05 22.6 0.2 7.8 9 0 0 9 9 9 6 EF-hand domain EF-hand_1 PF00036.27 KOO26196.1 - 1.6e-27 92.6 24.2 0.00028 19.9 0.0 7.6 8 0 0 8 8 8 6 EF hand EF-hand_7 PF13499.1 KOO26196.1 - 1.4e-24 85.9 16.9 1.7e-09 37.6 0.2 4.8 3 1 1 5 5 5 4 EF-hand domain pair EF-hand_8 PF13833.1 KOO26196.1 - 1.3e-20 72.7 15.6 8.1e-08 31.7 0.0 5.6 4 2 2 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.1 KOO26196.1 - 2.3e-16 58.3 23.8 0.00029 20.0 0.1 7.0 8 0 0 8 8 8 5 EF hand SPARC_Ca_bdg PF10591.4 KOO26196.1 - 3.6e-05 23.7 2.6 1.7 8.7 0.0 3.8 4 0 0 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO26196.1 - 0.1 12.3 1.7 20 4.9 0.0 4.3 5 0 0 5 5 5 0 EF hand EF-hand_4 PF12763.2 KOO26196.1 - 2.9 7.6 8.4 1.5 8.5 0.1 3.8 3 2 3 6 6 6 0 Cytoskeletal-regulatory complex EF hand UPF0118 PF01594.11 KOO26197.1 - 8.4e-36 123.5 31.4 1.5e-32 112.8 15.2 3.0 2 1 0 2 2 2 2 Domain of unknown function DUF20 RPE65 PF03055.10 KOO26199.1 - 1.4e-24 86.5 0.0 2.2e-20 72.7 0.0 2.0 1 1 1 2 2 2 2 Retinal pigment epithelial membrane protein Sulfotransfer_2 PF03567.9 KOO26201.1 - 1.7e-06 27.9 0.4 2.3e-06 27.5 0.3 1.2 1 0 0 1 1 1 1 Sulfotransferase family RNA_pol_Rpb1_1 PF04997.7 KOO26202.1 - 6.7e-57 193.2 1.2 2.4e-49 168.4 0.0 3.4 1 1 2 3 3 3 3 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.15 KOO26202.1 - 5.6e-49 166.2 0.3 2.8e-48 164.0 0.0 2.3 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_5 PF04998.12 KOO26202.1 - 4.9e-16 58.8 0.0 7.7e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_3 PF04983.13 KOO26202.1 - 1.2e-07 31.6 0.2 1.7e-05 24.6 0.0 3.2 1 1 2 3 3 3 1 RNA polymerase Rpb1, domain 3 Hairpins PF04877.7 KOO26202.1 - 0.035 13.5 0.4 0.55 9.5 0.1 2.4 2 0 0 2 2 2 0 HrpZ DUF4041 PF13250.1 KOO26202.1 - 0.064 12.8 1.5 0.61 9.6 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4041) EF-hand_8 PF13833.1 KOO26204.1 - 1.7e-15 56.3 0.3 2.9e-12 45.9 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO26204.1 - 2.1e-15 54.7 1.0 6.1e-07 28.2 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO26204.1 - 2.3e-14 53.2 0.1 5.3e-14 52.0 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO26204.1 - 8.2e-13 47.0 0.6 2e-06 27.1 0.0 3.0 2 1 1 3 3 3 2 EF-hand domain EF-hand_5 PF13202.1 KOO26204.1 - 2.3e-12 45.6 5.9 1.1e-05 24.5 0.1 2.9 3 0 0 3 3 3 2 EF hand FKBP_C PF00254.23 KOO26204.1 - 1.3e-07 31.4 0.0 2.7e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase SPARC_Ca_bdg PF10591.4 KOO26204.1 - 0.036 14.0 0.0 0.061 13.3 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Arm PF00514.18 KOO26205.1 - 1.3e-36 123.1 14.7 3.1e-05 23.6 0.0 7.6 7 0 0 7 7 7 7 Armadillo/beta-catenin-like repeat Aa_trans PF01490.13 KOO26205.1 - 1.2e-34 119.4 21.9 1e-19 70.3 0.2 2.2 1 1 0 2 2 2 2 Transmembrane amino acid transporter protein ART PF01129.13 KOO26205.1 - 0.00012 21.2 0.0 0.00022 20.4 0.0 1.3 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Arm_2 PF04826.8 KOO26205.1 - 0.00053 19.1 0.1 0.99 8.4 0.0 3.3 1 1 2 4 4 4 4 Armadillo-like CPL PF08144.6 KOO26205.1 - 1.3 8.8 4.5 1.5 8.6 0.8 2.7 1 1 2 3 3 3 0 CPL (NUC119) domain DUF4511 PF14974.1 KOO26207.1 - 1.2e-10 41.0 0.1 1.7e-10 40.6 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4511) TPR_1 PF00515.23 KOO26208.1 - 0.014 14.9 2.3 0.039 13.5 0.2 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.1 KOO26208.1 - 0.024 14.2 0.8 0.1 12.2 0.0 2.4 3 0 0 3 3 3 0 TPR repeat Apc3 PF12895.2 KOO26208.1 - 0.048 13.8 0.7 0.12 12.5 0.1 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 KOO26208.1 - 2.1 8.4 4.6 0.94 9.5 0.3 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat AAA PF00004.24 KOO26209.1 - 2.3e-27 95.7 0.0 1.4e-11 44.7 0.0 3.6 3 0 0 3 3 3 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOO26209.1 - 1.7e-09 37.8 2.4 0.1 12.7 0.1 5.3 4 1 0 4 4 4 3 AAA domain RuvB_N PF05496.7 KOO26209.1 - 5.8e-07 28.7 0.0 0.31 10.0 0.0 3.7 3 0 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 KOO26209.1 - 2.8e-05 24.9 0.1 0.048 14.4 0.0 3.2 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 KOO26209.1 - 6.4e-05 22.2 1.3 0.37 9.9 0.0 3.7 3 1 1 4 4 4 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.1 KOO26209.1 - 8.7e-05 22.8 0.7 0.054 13.7 0.1 3.1 3 0 0 3 3 2 1 AAA domain RNA_helicase PF00910.17 KOO26209.1 - 8.8e-05 22.6 0.0 0.14 12.3 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_5 PF07728.9 KOO26209.1 - 9.5e-05 22.1 0.1 0.19 11.4 0.0 3.4 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) Sigma54_activ_2 PF14532.1 KOO26209.1 - 0.00016 21.7 0.0 0.85 9.6 0.0 3.8 3 0 0 3 3 3 1 Sigma-54 interaction domain Thioredoxin PF00085.15 KOO26209.1 - 0.00071 19.2 0.1 0.0016 18.0 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Sigma54_activat PF00158.21 KOO26209.1 - 0.00097 18.6 1.9 1.2 8.5 0.0 4.0 5 0 0 5 5 4 1 Sigma-54 interaction domain AAA_19 PF13245.1 KOO26209.1 - 0.0015 18.2 3.8 0.083 12.6 0.0 3.4 3 0 0 3 3 3 1 Part of AAA domain AAA_24 PF13479.1 KOO26209.1 - 0.0017 17.9 0.5 0.039 13.5 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 KOO26209.1 - 0.0018 18.1 3.0 1.3 8.9 0.0 3.2 4 0 0 4 4 3 2 AAA domain AAA_16 PF13191.1 KOO26209.1 - 0.0068 16.4 1.1 0.25 11.3 0.0 3.1 2 1 1 3 3 3 1 AAA ATPase domain IstB_IS21 PF01695.12 KOO26209.1 - 0.022 14.1 0.4 1.4 8.3 0.1 2.8 3 0 0 3 3 2 0 IstB-like ATP binding protein AAA_25 PF13481.1 KOO26209.1 - 0.025 13.9 3.0 8.5 5.7 0.0 4.0 3 1 1 4 4 4 0 AAA domain Zot PF05707.7 KOO26209.1 - 0.028 13.9 0.1 25 4.2 0.0 3.7 4 0 0 4 4 4 0 Zonular occludens toxin (Zot) NTPase_1 PF03266.10 KOO26209.1 - 0.029 14.0 0.8 5.3 6.7 0.0 3.0 3 0 0 3 3 3 0 NTPase NACHT PF05729.7 KOO26209.1 - 0.04 13.5 0.6 11 5.6 0.0 3.3 4 0 0 4 4 3 0 NACHT domain KTI12 PF08433.5 KOO26209.1 - 0.066 12.4 0.1 4.5 6.3 0.0 2.3 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_3 PF07726.6 KOO26209.1 - 0.068 12.7 0.0 0.67 9.5 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Seryl_tRNA_N PF02403.17 KOO26209.1 - 0.1 12.6 1.3 58 3.7 0.0 4.3 4 0 0 4 4 4 0 Seryl-tRNA synthetase N-terminal domain ABC_tran PF00005.22 KOO26209.1 - 0.13 12.5 0.3 3.2 8.0 0.0 2.8 2 0 0 2 2 2 0 ABC transporter Viral_helicase1 PF01443.13 KOO26209.1 - 0.24 10.9 1.3 2.5 7.5 0.0 2.7 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA_13 PF13166.1 KOO26209.1 - 0.26 9.7 0.1 0.43 8.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF342 PF03961.8 KOO26211.1 - 0.072 11.4 6.5 0.09 11.1 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Cystatin PF00031.16 KOO26212.1 - 0.00013 22.0 0.0 0.0003 20.8 0.0 1.6 1 0 0 1 1 1 1 Cystatin domain BAR_2 PF10455.4 KOO26216.1 - 0.064 12.1 0.1 0.084 11.7 0.1 1.1 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking Filamin PF00630.14 KOO26218.1 - 2e-43 147.0 0.0 3e-15 56.5 0.0 5.8 5 1 0 5 5 5 4 Filamin/ABP280 repeat SH3_3 PF08239.6 KOO26218.1 - 0.00042 20.4 0.1 0.0018 18.3 0.0 2.1 2 0 0 2 2 2 1 Bacterial SH3 domain CopC PF04234.7 KOO26218.1 - 0.019 15.5 0.3 12 6.6 0.0 3.9 4 0 0 4 4 4 0 CopC domain WD40 PF00400.27 KOO26219.1 - 1e-22 79.0 8.0 4.1e-06 26.4 0.1 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat Nucleoporin_N PF08801.6 KOO26219.1 - 0.023 13.4 0.0 0.043 12.5 0.0 1.4 1 0 0 1 1 1 0 Nup133 N terminal like Nup160 PF11715.3 KOO26219.1 - 0.042 11.9 0.0 2.3 6.2 0.0 2.2 1 1 0 2 2 2 0 Nucleoporin Nup120/160 Glyoxal_oxid_N PF07250.6 KOO26219.1 - 0.28 10.2 1.4 6.1 5.8 0.0 2.5 2 1 0 2 2 2 0 Glyoxal oxidase N-terminus PQQ_3 PF13570.1 KOO26219.1 - 0.36 11.1 3.2 7.3 7.0 0.1 3.9 4 0 0 4 4 4 0 PQQ-like domain VID27 PF08553.5 KOO26220.1 - 2e-12 46.2 0.0 2.6e-12 45.8 0.0 1.0 1 0 0 1 1 1 1 VID27 cytoplasmic protein PH_2 PF08458.5 KOO26220.1 - 0.064 13.1 0.1 0.16 11.9 0.1 1.7 1 0 0 1 1 1 0 Plant pleckstrin homology-like region CBM_6 PF03422.10 KOO26220.1 - 0.067 13.3 0.1 0.95 9.6 0.0 2.4 2 0 0 2 2 2 0 Carbohydrate binding module (family 6) DUF2460 PF09343.5 KOO26220.1 - 0.12 11.6 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical protein 2217 (DUF2460) ubiquitin PF00240.18 KOO26221.1 - 0.00038 19.7 0.0 1 8.8 0.0 3.2 4 0 0 4 4 4 2 Ubiquitin family Rad60-SLD PF11976.3 KOO26221.1 - 0.086 12.5 0.0 1.5 8.5 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Ion_trans PF00520.26 KOO26222.1 - 1.6e-18 66.7 1.7 3.1e-18 65.7 1.2 1.5 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO26222.1 - 2.8e-16 58.9 1.5 2.8e-16 58.9 1.0 2.4 2 0 0 2 2 2 1 Ion channel EF-hand_5 PF13202.1 KOO26222.1 - 6.9e-05 22.0 1.4 0.00048 19.3 0.1 2.6 2 1 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO26222.1 - 8.5e-05 22.1 0.3 0.32 11.0 0.0 3.0 2 1 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO26222.1 - 0.00014 21.9 0.2 0.0015 18.5 0.2 2.2 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO26222.1 - 0.0002 20.4 0.1 0.0061 15.7 0.1 2.4 2 0 0 2 2 2 1 EF hand zf-ribbon_3 PF13248.1 KOO26222.1 - 0.055 12.6 4.5 0.095 11.9 3.1 1.3 1 0 0 1 1 1 0 zinc-ribbon domain DZR PF12773.2 KOO26222.1 - 0.056 13.2 1.1 0.095 12.5 0.8 1.2 1 0 0 1 1 1 0 Double zinc ribbon EF-hand_8 PF13833.1 KOO26222.1 - 0.057 13.0 0.0 0.13 11.8 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair zinc_ribbon_2 PF13240.1 KOO26222.1 - 0.81 9.2 3.7 1.6 8.3 2.6 1.5 1 0 0 1 1 1 0 zinc-ribbon domain PKD_channel PF08016.7 KOO26223.1 - 4.4e-15 55.0 20.8 8.1e-15 54.1 12.4 2.6 3 1 0 3 3 3 1 Polycystin cation channel Dimer_Tnp_hAT PF05699.9 KOO26224.1 - 2.7e-06 26.8 0.1 2.9e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF2389 PF09493.5 KOO26224.1 - 0.088 13.0 0.2 0.25 11.6 0.0 1.8 2 0 0 2 2 2 0 Tryptophan-rich protein (DUF2389) LRR_6 PF13516.1 KOO26225.1 - 0.04 13.9 0.1 9.6 6.6 0.0 2.2 2 0 0 2 2 2 0 Leucine Rich repeat PCMT PF01135.14 KOO26226.1 - 4.7e-28 98.1 0.0 6.7e-28 97.6 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) KOW PF00467.24 KOO26226.1 - 1e-05 25.0 3.3 1.2e-05 24.8 0.7 2.2 2 0 0 2 2 2 1 KOW motif Methyltransf_18 PF12847.2 KOO26226.1 - 0.016 15.8 0.0 0.029 14.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.13 KOO26226.1 - 0.017 14.2 0.0 0.026 13.6 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 KOO26226.1 - 0.073 13.1 0.1 0.15 12.1 0.1 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 KOO26226.1 - 0.16 11.5 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain TPR_11 PF13414.1 KOO26227.1 - 2.9e-19 68.4 11.5 3.4e-15 55.4 2.0 2.3 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 KOO26227.1 - 2e-14 52.2 10.6 4.5e-05 23.0 0.4 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO26227.1 - 2.4e-13 49.0 9.5 3e-05 23.4 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat CS PF04969.11 KOO26227.1 - 6.1e-09 36.3 0.0 1.2e-08 35.3 0.0 1.5 1 0 0 1 1 1 1 CS domain TPR_16 PF13432.1 KOO26227.1 - 9.8e-06 26.0 17.4 0.0001 22.8 0.8 2.8 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO26227.1 - 1.2e-05 25.0 1.0 0.25 11.6 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO26227.1 - 2.2e-05 23.8 0.8 0.23 11.3 0.0 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO26227.1 - 7.1e-05 23.0 13.2 0.0031 17.8 0.6 3.1 3 0 0 3 3 2 2 Tetratricopeptide repeat CAP_C PF08603.6 KOO26227.1 - 0.0001 21.6 0.0 0.0002 20.7 0.0 1.4 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TPR_14 PF13428.1 KOO26227.1 - 0.00012 22.3 6.5 0.023 15.2 1.2 3.9 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO26227.1 - 0.00036 20.3 7.9 0.00072 19.4 1.3 2.9 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO26227.1 - 0.0061 16.2 4.3 3.7 7.5 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 KOO26227.1 - 0.026 14.6 3.6 0.037 14.1 1.2 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 KOO26227.1 - 0.031 14.7 4.4 1.3 9.6 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TBCC PF07986.7 KOO26227.1 - 0.064 12.6 0.3 0.63 9.4 0.1 2.2 1 1 1 2 2 2 0 Tubulin binding cofactor C TPR_9 PF13371.1 KOO26227.1 - 0.49 10.2 10.8 0.11 12.3 0.7 3.0 2 1 1 3 3 2 0 Tetratricopeptide repeat NAD_binding_10 PF13460.1 KOO26230.1 - 9.4e-19 68.1 0.0 2.1e-18 67.0 0.0 1.5 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 KOO26230.1 - 7.2e-06 25.5 0.0 1.2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 KOO26230.1 - 0.00078 18.2 0.0 0.0011 17.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.15 KOO26230.1 - 0.043 13.7 0.1 0.078 12.8 0.0 1.6 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NmrA PF05368.8 KOO26230.1 - 0.14 11.3 0.1 0.21 10.7 0.1 1.2 1 0 0 1 1 1 0 NmrA-like family Chloroa_b-bind PF00504.16 KOO26231.1 - 1.6e-35 122.6 0.0 1.9e-35 122.4 0.0 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Zip PF02535.17 KOO26232.1 - 1.5e-38 132.5 13.3 2e-38 132.1 9.2 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter LRR_4 PF12799.2 KOO26234.1 - 4.6e-20 70.7 38.9 0.0013 18.2 0.6 10.2 7 2 4 11 11 11 8 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO26234.1 - 4.7e-14 50.8 29.1 0.0071 16.3 0.1 11.4 11 1 1 12 12 12 5 Leucine Rich repeat EF-hand_5 PF13202.1 KOO26234.1 - 0.0012 18.0 0.0 0.005 16.1 0.0 2.1 2 0 0 2 2 2 1 EF hand LRR_1 PF00560.28 KOO26234.1 - 0.0051 16.6 26.0 12 6.4 0.0 11.1 11 1 1 12 12 12 0 Leucine Rich Repeat Miro PF08477.8 KOO26234.1 - 0.0065 16.9 0.0 0.03 14.8 0.0 2.2 2 0 0 2 2 2 1 Miro-like protein EF-hand_1 PF00036.27 KOO26234.1 - 0.0083 15.3 0.0 0.037 13.3 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO26234.1 - 0.027 14.5 0.5 0.57 10.3 0.4 3.0 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.1 KOO26234.1 - 0.032 14.0 0.7 0.15 12.0 0.0 2.5 3 0 0 3 3 1 0 EF-hand domain PduV-EutP PF10662.4 KOO26234.1 - 0.041 13.3 0.0 0.17 11.4 0.0 2.1 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation EF-hand_8 PF13833.1 KOO26234.1 - 0.062 12.9 0.0 0.28 10.8 0.0 2.1 1 0 0 1 1 1 0 EF-hand domain pair UvrD-helicase PF00580.16 KOO26234.1 - 0.12 11.6 1.3 0.23 10.7 0.0 2.1 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain GTP_EFTU PF00009.22 KOO26234.1 - 0.14 11.5 0.0 0.53 9.6 0.0 1.9 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Ras PF00071.17 KOO26234.1 - 0.23 10.8 0.0 0.46 9.8 0.0 1.5 1 0 0 1 1 1 0 Ras family LRR_7 PF13504.1 KOO26234.1 - 0.86 10.0 30.7 35 5.2 0.0 12.1 12 0 0 12 12 11 0 Leucine rich repeat Ric8 PF10165.4 KOO26235.1 - 1.6e-10 40.4 0.0 3.1e-10 39.4 0.0 1.5 1 1 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Bac_rhodopsin PF01036.13 KOO26236.1 - 0.028 13.7 6.3 0.045 13.0 4.4 1.3 1 0 0 1 1 1 0 Bacteriorhodopsin-like protein EOS1 PF12326.3 KOO26236.1 - 0.088 12.4 3.3 0.39 10.3 1.0 2.2 2 0 0 2 2 2 0 N-glycosylation protein Ribosomal_L27 PF01016.14 KOO26237.1 - 4.9e-29 99.9 0.1 7.3e-29 99.3 0.1 1.3 1 0 0 1 1 1 1 Ribosomal L27 protein Mu-like_Com PF10122.4 KOO26237.1 - 0.044 12.8 0.0 0.082 11.9 0.0 1.4 1 0 0 1 1 1 0 Mu-like prophage protein Com TPR_11 PF13414.1 KOO26238.1 - 1.4e-06 27.7 2.4 1.4e-06 27.7 1.7 2.7 3 0 0 3 3 3 1 TPR repeat TPR_17 PF13431.1 KOO26238.1 - 0.004 17.2 0.2 0.014 15.5 0.1 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO26238.1 - 0.019 15.6 1.7 0.019 15.6 1.2 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOO26238.1 - 0.023 14.2 3.5 0.075 12.6 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO26238.1 - 0.13 12.9 0.2 0.13 12.9 0.1 4.2 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO26238.1 - 0.22 11.4 0.2 0.22 11.4 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat ARS2 PF04959.8 KOO26239.1 - 1.5e-09 38.3 0.0 2.9e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Arsenite-resistance protein 2 DUF3546 PF12066.3 KOO26239.1 - 0.0013 18.6 0.0 0.0025 17.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3546) C2 PF00168.25 KOO26242.1 - 1e-15 57.3 0.0 1.1e-06 28.3 0.0 3.9 5 0 0 5 5 5 2 C2 domain FerI PF08151.7 KOO26242.1 - 6.2e-08 32.5 0.0 1.5e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 FerI (NUC094) domain EF-hand_7 PF13499.1 KOO26243.1 - 5.2e-16 58.5 0.2 2.7e-05 24.1 0.0 5.8 4 3 3 7 7 7 4 EF-hand domain pair EF-hand_1 PF00036.27 KOO26243.1 - 7.1e-12 43.7 7.1 0.0006 18.9 0.0 7.3 8 0 0 8 8 8 3 EF hand EF-hand_6 PF13405.1 KOO26243.1 - 4.5e-09 35.4 7.5 0.035 13.9 0.0 6.8 7 1 0 7 7 7 2 EF-hand domain EF-hand_8 PF13833.1 KOO26243.1 - 1.8e-08 33.8 5.5 0.13 11.9 0.0 6.2 7 0 0 7 7 7 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO26243.1 - 3.4e-08 32.4 1.5 0.00013 21.1 0.0 3.6 3 0 0 3 3 3 2 EF hand EF-hand_10 PF14788.1 KOO26243.1 - 0.00068 19.2 0.1 3.7 7.2 0.0 3.9 5 0 0 5 5 5 2 EF hand EF-hand_4 PF12763.2 KOO26243.1 - 0.001 18.7 0.1 0.028 14.1 0.0 3.0 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO26243.1 - 0.0031 17.5 0.0 1.2 9.2 0.0 2.8 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region ADP_ribosyl_GH PF03747.9 KOO26244.1 - 1.3e-13 51.4 0.1 1.6e-13 51.1 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase PAS_9 PF13426.1 KOO26245.1 - 5.7e-11 42.7 0.0 0.00015 22.1 0.0 2.4 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.5 KOO26245.1 - 0.0014 18.6 0.0 0.45 10.5 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS PF00989.19 KOO26245.1 - 0.09 12.5 0.0 0.23 11.2 0.0 1.7 1 0 0 1 1 1 0 PAS fold Hydrolase_6 PF13344.1 KOO26246.1 - 2.7e-11 43.2 0.0 5.3e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOO26246.1 - 0.00024 20.7 0.0 0.00071 19.2 0.0 1.8 1 0 0 1 1 1 1 HAD-hyrolase-like Pericardin_rpt PF07054.6 KOO26246.1 - 1 9.2 15.6 1.4 8.9 2.6 3.3 1 1 1 2 2 2 0 Pericardin like repeat zf-RanBP PF00641.13 KOO26247.1 - 1.9e-08 33.2 10.0 0.00043 19.3 3.0 2.7 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others Trypsin_2 PF13365.1 KOO26247.1 - 5e-08 32.9 0.0 1.5e-07 31.4 0.0 1.9 1 0 0 1 1 1 1 Trypsin-like peptidase domain dsrm PF00035.20 KOO26247.1 - 0.18 12.3 0.6 41 4.8 0.3 2.8 2 0 0 2 2 2 0 Double-stranded RNA binding motif AAA_12 PF13087.1 KOO26248.1 - 3.7e-36 124.4 0.0 8.4e-36 123.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 KOO26248.1 - 2.7e-24 86.0 4.6 1.6e-23 83.5 0.0 3.0 3 0 0 3 3 3 1 AAA domain zf-CCCH PF00642.19 KOO26248.1 - 1.2e-07 31.2 2.7 2.4e-07 30.2 1.9 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) AAA_16 PF13191.1 KOO26248.1 - 2.7e-06 27.5 0.5 2.7e-06 27.5 0.3 3.7 4 0 0 4 4 4 1 AAA ATPase domain AAA_19 PF13245.1 KOO26248.1 - 4.8e-05 23.0 0.6 0.0022 17.7 0.0 3.6 3 0 0 3 3 3 1 Part of AAA domain AAA_5 PF07728.9 KOO26248.1 - 0.0025 17.5 0.0 0.033 13.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 KOO26248.1 - 0.0073 17.1 0.0 0.03 15.1 0.0 2.1 1 0 0 1 1 1 1 AAA domain zf-CCCH_2 PF14608.1 KOO26248.1 - 0.0097 15.8 3.6 0.021 14.8 2.5 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type AAA_25 PF13481.1 KOO26248.1 - 0.012 15.0 0.0 0.012 15.0 0.0 2.9 4 0 0 4 4 4 0 AAA domain DUF2075 PF09848.4 KOO26248.1 - 0.014 14.4 0.1 0.13 11.1 0.0 2.8 4 0 0 4 4 4 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.1 KOO26248.1 - 0.016 15.3 0.3 0.35 11.0 0.0 3.0 2 1 1 3 3 3 0 AAA domain RNA_helicase PF00910.17 KOO26248.1 - 0.056 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase BRO1 PF03097.13 KOO26250.1 - 2.7e-80 269.9 2.7 2.1e-78 263.7 2.9 2.2 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 KOO26250.1 - 1.3e-33 116.3 0.0 3.3e-33 114.9 0.0 1.7 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV Med4 PF10018.4 KOO26250.1 - 0.018 14.4 0.0 0.19 11.1 0.0 2.6 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 BAF1_ABF1 PF04684.8 KOO26252.1 - 0.083 11.7 0.9 0.12 11.1 0.6 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SRP_SPB PF02978.14 KOO26253.1 - 0.00033 20.8 0.8 0.00077 19.6 0.1 2.0 1 1 0 1 1 1 1 Signal peptide binding domain DUF3373 PF11853.3 KOO26253.1 - 0.022 13.2 0.3 0.029 12.9 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Queuosine_synth PF02547.10 KOO26253.1 - 0.097 11.3 0.7 0.12 11.0 0.5 1.2 1 0 0 1 1 1 0 Queuosine biosynthesis protein DUF4618 PF15397.1 KOO26253.1 - 0.19 11.0 5.2 0.27 10.5 3.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Peptidase_S10 PF00450.17 KOO26254.1 - 1.8e-93 313.9 0.2 2.7e-93 313.4 0.1 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase TPR_12 PF13424.1 KOO26254.1 - 5.9e-30 103.0 6.7 1.7e-11 43.8 0.6 5.2 5 1 0 5 5 4 3 Tetratricopeptide repeat TPR_10 PF13374.1 KOO26254.1 - 2.5e-28 97.1 13.2 4.2e-08 32.8 0.1 6.2 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_11 PF13414.1 KOO26254.1 - 2e-10 40.1 1.0 0.00027 20.5 0.3 3.3 2 1 1 3 3 3 3 TPR repeat TPR_2 PF07719.12 KOO26254.1 - 1.9e-09 36.7 6.5 0.13 12.2 0.0 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO26254.1 - 3.7e-09 35.8 1.2 0.32 10.6 0.1 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_16 PF13432.1 KOO26254.1 - 7e-05 23.3 21.5 0.0015 19.1 0.9 5.4 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO26254.1 - 0.0011 18.5 4.8 0.3 10.9 0.0 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO26254.1 - 0.0044 17.5 16.8 2 9.3 0.0 6.4 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO26254.1 - 0.017 14.8 0.7 31 4.6 0.0 4.2 4 1 1 5 5 5 0 Tetratricopeptide repeat Apc3 PF12895.2 KOO26254.1 - 0.079 13.1 2.9 0.32 11.1 0.1 3.3 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.9 KOO26254.1 - 1.1 9.9 11.4 12 6.7 0.0 5.9 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO26254.1 - 3.4 8.3 10.6 8.2 7.1 0.1 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat Pkinase PF00069.20 KOO26255.1 - 0.012 14.7 0.0 0.18 10.9 0.0 2.0 2 0 0 2 2 2 0 Protein kinase domain zf-C2H2 PF00096.21 KOO26256.1 - 4.7e-11 42.3 22.4 0.0015 18.7 0.2 4.3 3 1 1 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOO26256.1 - 2.1e-06 27.6 20.0 0.078 13.3 0.2 4.2 3 1 1 4 4 4 3 C2H2-type zinc finger zf-met PF12874.2 KOO26256.1 - 1.1e-05 25.4 8.7 0.039 14.1 0.2 3.7 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 KOO26256.1 - 3.4e-05 23.5 9.9 0.0014 18.4 0.0 3.9 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KOO26256.1 - 5e-05 23.3 17.0 0.00037 20.5 0.3 3.6 4 1 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.7 KOO26256.1 - 8.4e-05 22.6 3.1 0.56 10.3 0.0 2.6 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding HypA PF01155.14 KOO26256.1 - 0.027 14.1 1.8 0.03 14.0 0.2 1.8 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family zinc_ribbon_4 PF13717.1 KOO26256.1 - 0.072 12.7 3.3 1.1 8.9 0.0 3.2 3 0 0 3 3 3 0 zinc-ribbon domain zf-H2C2_2 PF13465.1 KOO26256.1 - 0.087 13.1 25.1 0.31 11.4 2.0 5.3 6 1 0 6 6 5 0 Zinc-finger double domain zf-C2H2_2 PF12756.2 KOO26256.1 - 0.093 12.8 13.6 0.5 10.5 0.0 3.8 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_5 PF13719.1 KOO26256.1 - 0.16 11.5 5.1 0.88 9.2 0.0 3.2 3 0 0 3 3 3 0 zinc-ribbon domain CpXC PF14353.1 KOO26256.1 - 0.25 11.3 5.8 4 7.4 0.0 3.1 3 0 0 3 3 3 0 CpXC protein zf-BED PF02892.10 KOO26256.1 - 0.5 10.1 0.0 0.5 10.1 0.0 3.8 3 1 0 3 3 3 0 BED zinc finger zf-trcl PF13451.1 KOO26256.1 - 0.5 10.0 9.0 0.097 12.3 2.7 2.3 2 0 0 2 2 2 0 Probable zinc-binding domain Zn-ribbon_8 PF09723.5 KOO26256.1 - 6.8 6.7 9.8 34 4.5 3.1 3.4 2 1 0 2 2 2 0 Zinc ribbon domain DUF3735 PF12537.3 KOO26257.1 - 0.011 15.7 1.9 4.7 7.3 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3735) PigN PF04987.9 KOO26257.1 - 0.035 12.7 1.3 1.7 7.2 0.2 2.2 1 1 1 2 2 2 0 Phosphatidylinositolglycan class N (PIG-N) FAST_1 PF06743.10 KOO26258.1 - 7.1e-12 44.8 0.2 2.4 7.9 0.0 8.1 1 1 8 9 9 9 4 FAST kinase-like protein, subdomain 1 DUF1601 PF07671.6 KOO26258.1 - 0.00042 19.8 16.2 0.34 10.5 0.0 7.0 8 0 0 8 8 8 3 Protein of unknown function (DUF1601) ING PF12998.2 KOO26260.1 - 1.9e-12 47.3 4.4 3.2e-12 46.6 3.0 1.4 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding DUF1325 PF07039.6 KOO26260.1 - 1.6e-08 34.2 0.0 3.9e-05 23.2 0.0 2.5 1 1 1 2 2 2 2 SGF29 tudor-like domain Elongin_A PF06881.6 KOO26260.1 - 0.67 10.3 4.0 1.4 9.3 2.8 1.6 1 1 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A DAHP_synth_1 PF00793.15 KOO26262.1 - 1.5e-37 128.8 0.0 4.7e-20 71.4 0.0 2.4 2 1 0 2 2 2 2 DAHP synthetase I family Acatn PF13000.2 KOO26264.1 - 1.9e-44 152.1 10.9 5e-25 88.0 1.6 3.7 1 1 1 2 2 2 2 Acetyl-coenzyme A transporter 1 Pentapeptide_4 PF13599.1 KOO26265.1 - 2.1e-06 27.4 0.0 0.011 15.5 0.1 3.3 1 1 2 3 3 3 2 Pentapeptide repeats (9 copies) N_methyl_2 PF13544.1 KOO26265.1 - 0.00042 19.6 3.0 2.1 7.9 0.0 4.7 4 1 1 5 5 5 2 Type IV pilin N-term methylation site GFxxxE MerR-DNA-bind PF09278.6 KOO26265.1 - 0.00077 19.8 3.4 11 6.5 0.0 5.9 4 1 1 5 5 5 2 MerR, DNA binding Ribosomal_L13e PF01294.13 KOO26265.1 - 0.0047 16.4 3.0 3.1 7.2 0.0 4.9 2 2 4 6 6 6 1 Ribosomal protein L13e CorA PF01544.13 KOO26266.1 - 8.5e-07 28.2 3.9 1.4e-06 27.5 0.1 2.4 2 1 0 2 2 2 1 CorA-like Mg2+ transporter protein DUF2721 PF11026.3 KOO26266.1 - 0.00014 21.5 2.2 0.00015 21.4 0.4 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2721) DUF737 PF05300.6 KOO26267.1 - 1.8 8.4 16.2 0.15 12.0 5.6 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF737) Methyltransf_18 PF12847.2 KOO26268.1 - 5.2e-08 33.4 0.0 1e-07 32.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO26268.1 - 2.9e-07 30.3 0.0 5.3e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO26268.1 - 1e-06 29.0 0.0 2.2e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 KOO26268.1 - 4e-05 22.8 0.0 8e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.7 KOO26268.1 - 0.00014 22.3 0.0 0.00025 21.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 KOO26268.1 - 0.00037 20.0 0.0 0.00065 19.2 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DOT1 PF08123.8 KOO26268.1 - 0.00085 18.6 0.0 0.0018 17.5 0.0 1.4 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_31 PF13847.1 KOO26268.1 - 0.0025 17.4 0.0 0.0036 16.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 KOO26268.1 - 0.0082 15.8 0.0 0.017 14.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO26268.1 - 0.062 13.3 0.1 0.14 12.2 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Arm PF00514.18 KOO26269.1 - 7.2e-21 73.2 38.2 0.00042 20.0 0.1 8.7 8 1 0 8 8 8 7 Armadillo/beta-catenin-like repeat U-box PF04564.10 KOO26269.1 - 8.4e-18 64.1 0.0 1.8e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO26269.1 - 2.3e-05 23.8 0.0 4.4e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 KOO26269.1 - 0.021 14.5 0.0 0.044 13.5 0.0 1.5 1 0 0 1 1 1 0 RING-type zinc-finger HTH_OrfB_IS605 PF12323.3 KOO26270.1 - 0.00018 20.7 13.2 0.11 11.8 0.0 4.8 5 0 0 5 5 5 2 Helix-turn-helix domain Fis1_TPR_C PF14853.1 KOO26270.1 - 0.0025 17.6 5.6 7.1 6.6 0.0 4.9 6 0 0 6 6 6 2 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.1 KOO26270.1 - 0.08 12.8 16.9 0.56 10.1 1.6 4.4 2 2 1 4 4 4 0 Tetratricopeptide repeat FSH1 PF03959.8 KOO26271.1 - 7.3e-14 51.7 0.1 2.3e-12 46.8 0.0 2.1 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.2 KOO26271.1 - 0.00062 19.7 5.3 0.0023 17.8 3.6 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO26271.1 - 0.005 16.6 0.1 0.0065 16.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Methyltransf_11 PF08241.7 KOO26272.1 - 2.6e-08 34.2 0.0 5.8e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO26272.1 - 3.8e-06 26.7 0.0 6.7e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DSBA PF01323.15 KOO26272.1 - 0.00011 21.8 0.0 0.00025 20.6 0.0 1.5 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Ubie_methyltran PF01209.13 KOO26272.1 - 0.0013 17.8 0.0 0.0022 17.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 KOO26272.1 - 0.0015 18.1 0.0 0.0026 17.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain N6_N4_Mtase PF01555.13 KOO26272.1 - 0.0049 16.3 0.0 0.0076 15.7 0.0 1.2 1 0 0 1 1 1 1 DNA methylase Methyltransf_12 PF08242.7 KOO26272.1 - 0.0051 17.2 0.0 0.013 15.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 KOO26272.1 - 0.014 14.7 0.0 0.029 13.7 0.0 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_25 PF13649.1 KOO26272.1 - 0.039 14.3 0.0 0.092 13.1 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain TPR_2 PF07719.12 KOO26273.1 - 9.9e-06 25.1 14.4 0.006 16.4 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO26273.1 - 4.9e-05 23.1 5.6 0.0011 18.8 0.7 3.6 2 2 3 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO26273.1 - 0.0001 21.8 0.4 0.0001 21.8 0.3 3.0 3 0 0 3 3 3 1 TPR repeat TPR_16 PF13432.1 KOO26273.1 - 0.0024 18.4 1.8 0.0024 18.4 1.2 4.7 3 2 1 4 4 3 2 Tetratricopeptide repeat AAA_16 PF13191.1 KOO26273.1 - 0.0082 16.1 8.4 0.0093 15.9 1.5 3.1 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 KOO26273.1 - 0.0084 16.2 0.7 0.038 14.1 0.1 2.3 2 1 0 2 2 2 1 AAA domain TPR_1 PF00515.23 KOO26273.1 - 0.01 15.4 11.6 0.12 11.9 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Zeta_toxin PF06414.7 KOO26273.1 - 0.017 14.1 0.2 0.052 12.6 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin Ecm33 PF12454.3 KOO26273.1 - 0.036 13.9 0.0 0.036 13.9 0.0 3.0 4 0 0 4 4 3 0 GPI-anchored cell wall organization protein AAA_23 PF13476.1 KOO26273.1 - 0.099 12.9 0.0 0.16 12.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain Apc3 PF12895.2 KOO26273.1 - 0.12 12.5 3.7 3 8.0 0.3 2.9 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 NACHT PF05729.7 KOO26273.1 - 0.14 11.8 0.1 0.26 10.9 0.1 1.4 1 0 0 1 1 1 0 NACHT domain TPR_8 PF13181.1 KOO26273.1 - 0.16 11.8 5.0 5.2 7.0 0.0 4.2 5 0 0 5 5 4 0 Tetratricopeptide repeat PI3K_1B_p101 PF10486.4 KOO26273.1 - 0.21 9.1 1.6 0.31 8.5 1.1 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit TPR_7 PF13176.1 KOO26273.1 - 0.75 9.7 8.3 8.8 6.3 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Hpt PF01627.18 KOO26273.1 - 1.5 8.9 7.6 0.37 10.8 0.8 3.4 2 2 0 2 2 2 0 Hpt domain EF-hand_1 PF00036.27 KOO26276.1 - 3.1e-12 44.8 2.4 2.5e-07 29.5 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO26276.1 - 9.4e-12 43.7 1.0 3.9e-06 26.2 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO26276.1 - 3.7e-10 39.7 2.6 1.4e-09 37.9 1.8 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO26276.1 - 4.6e-10 38.3 3.7 2.5e-06 26.5 0.7 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO26276.1 - 2.5e-05 23.7 3.5 0.0028 17.2 0.2 2.3 1 1 1 2 2 2 2 EF-hand domain pair DDRGK PF09756.4 KOO26276.1 - 9.2 5.6 12.3 15 4.9 8.5 1.3 1 0 0 1 1 1 0 DDRGK domain NACHT PF05729.7 KOO26277.1 - 4.4e-08 32.9 0.0 8.7e-08 31.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain LRR_6 PF13516.1 KOO26277.1 - 3.8e-06 26.4 0.2 0.0065 16.4 0.0 3.2 2 0 0 2 2 2 2 Leucine Rich repeat LRR_4 PF12799.2 KOO26277.1 - 0.00034 20.1 0.7 0.0063 16.1 0.1 2.7 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO26277.1 - 0.0058 16.4 0.0 7.4 7.0 0.0 3.3 3 0 0 3 3 3 2 Leucine Rich Repeat LRR_7 PF13504.1 KOO26277.1 - 0.041 14.0 0.1 13 6.5 0.0 3.8 3 0 0 3 3 3 0 Leucine rich repeat EF-hand_1 PF00036.27 KOO26278.1 - 7.5e-16 56.1 2.5 3.6e-07 29.0 0.1 2.2 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO26278.1 - 2.2e-13 50.1 0.4 2.5e-13 49.9 0.3 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO26278.1 - 3.8e-12 45.6 4.9 9.1e-10 38.0 0.4 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO26278.1 - 7.6e-12 44.0 1.0 8.6e-07 28.3 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO26278.1 - 2.2e-11 42.5 2.4 2.4e-05 23.4 0.1 2.2 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.1 KOO26278.1 - 1.2e-05 25.1 0.0 1.4e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO26278.1 - 0.00013 21.9 0.3 0.00016 21.6 0.2 1.2 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO26278.1 - 0.00019 21.1 0.2 0.00024 20.8 0.1 1.2 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand Transcrip_reg PF01709.15 KOO26278.1 - 0.0063 15.6 0.1 0.0095 15.0 0.1 1.3 1 0 0 1 1 1 1 Transcriptional regulator Mgr1 PF08602.5 KOO26278.1 - 0.0085 15.1 0.3 0.0093 15.0 0.2 1.0 1 0 0 1 1 1 1 Mgr1-like, i-AAA protease complex subunit Adenine_glyco PF03352.8 KOO26278.1 - 0.016 14.7 0.4 0.018 14.5 0.2 1.3 1 1 0 1 1 1 0 Methyladenine glycosylase EF-hand_10 PF14788.1 KOO26278.1 - 0.063 12.9 2.4 0.18 11.4 0.3 2.1 1 1 1 2 2 2 0 EF hand Rhomboid PF01694.17 KOO26279.1 - 0.00023 21.1 1.4 0.00023 21.1 1.0 1.7 2 0 0 2 2 2 1 Rhomboid family PepSY_TM_1 PF13172.1 KOO26279.1 - 0.0036 16.9 0.4 0.017 14.8 0.3 2.3 1 0 0 1 1 1 1 PepSY-associated TM helix HEAT PF02985.17 KOO26280.1 - 0.022 14.8 7.8 0.051 13.6 0.0 4.3 5 0 0 5 5 5 0 HEAT repeat HEAT_EZ PF13513.1 KOO26280.1 - 0.11 12.9 9.8 1 9.9 0.5 3.5 2 2 1 3 3 3 0 HEAT-like repeat HEAT_2 PF13646.1 KOO26280.1 - 0.22 11.8 7.9 0.36 11.1 0.2 2.9 2 2 1 3 3 3 0 HEAT repeats Pro_isomerase PF00160.16 KOO26283.1 - 2.1e-09 37.7 0.0 3e-09 37.2 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SCP2 PF02036.12 KOO26284.1 - 4.4e-11 42.9 1.6 0.0084 16.3 0.0 4.8 5 0 0 5 5 5 3 SCP-2 sterol transfer family Ank PF00023.25 KOO26285.1 - 4.1e-13 48.4 0.0 5.3e-07 29.1 0.0 3.2 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 KOO26285.1 - 1.2e-11 44.7 0.0 6.1e-11 42.5 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO26285.1 - 1.8e-09 36.9 0.1 6.7e-05 22.7 0.0 3.2 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 KOO26285.1 - 3.1e-09 36.7 0.1 1.1e-06 28.6 0.0 3.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO26285.1 - 2.6e-08 34.1 0.3 0.00021 21.6 0.1 2.9 1 1 2 3 3 3 2 Ankyrin repeats (many copies) ADPrib_exo_Tox PF03496.9 KOO26285.1 - 5.1e-07 29.0 0.0 1e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme FCH PF00611.18 KOO26285.1 - 5.2e-07 29.7 0.0 1.4e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain ART PF01129.13 KOO26285.1 - 0.00019 20.6 0.0 0.00045 19.3 0.0 1.6 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase LRR_6 PF13516.1 KOO26286.1 - 1.9e-16 58.2 0.3 0.00015 21.5 0.0 3.8 3 0 0 3 3 3 3 Leucine Rich repeat OTU PF02338.14 KOO26286.1 - 8.1e-14 52.2 0.0 4.8e-09 36.8 0.0 2.6 2 0 0 2 2 2 2 OTU-like cysteine protease MORN PF02493.15 KOO26286.1 - 0.00047 19.7 0.1 0.00094 18.7 0.0 1.5 1 0 0 1 1 1 1 MORN repeat DUF2538 PF10804.3 KOO26286.1 - 0.012 15.5 1.4 0.65 9.8 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2538) LRR_4 PF12799.2 KOO26286.1 - 0.03 13.9 0.1 0.1 12.2 0.0 1.9 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) SpoU_sub_bind PF08032.7 KOO26286.1 - 0.14 12.3 0.1 1.1 9.4 0.1 2.5 1 1 1 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding PAP_assoc PF03828.14 KOO26288.1 - 3.1e-09 36.6 0.0 5.2e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.18 KOO26288.1 - 5.1e-09 36.3 0.0 8.7e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain Nrap PF03813.9 KOO26288.1 - 0.071 10.6 0.0 0.094 10.2 0.0 1.0 1 0 0 1 1 1 0 Nrap protein HNH_4 PF13395.1 KOO26291.1 - 0.0044 16.6 0.0 0.01 15.4 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease UDPG_MGDP_dh_N PF03721.9 KOO26292.1 - 5.1e-44 149.8 0.0 1.1e-43 148.8 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.10 KOO26292.1 - 1.4e-30 105.5 0.1 3e-29 101.3 0.0 2.5 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.14 KOO26292.1 - 1.6e-26 92.3 0.0 3.6e-26 91.2 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain Sec63 PF02889.11 KOO26292.1 - 4.8e-07 29.3 0.0 0.015 14.5 0.1 2.3 1 1 1 2 2 2 2 Sec63 Brl domain NAD_Gly3P_dh_N PF01210.18 KOO26292.1 - 4.3e-06 26.5 0.6 2.1e-05 24.3 0.1 2.4 2 1 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.11 KOO26292.1 - 0.035 13.5 0.0 0.073 12.5 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA AIRS_C PF02769.17 KOO26294.1 - 4.2e-10 39.8 0.0 1.6e-09 37.9 0.0 1.9 1 1 0 1 1 1 1 AIR synthase related protein, C-terminal domain Pkinase PF00069.20 KOO26295.1 - 6.6e-60 202.4 0.0 9.5e-60 201.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO26295.1 - 1.8e-40 138.6 0.0 2.7e-40 138.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO26295.1 - 5.5e-07 28.8 0.0 1e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOO26295.1 - 0.0056 15.7 0.1 0.062 12.3 0.0 2.4 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Mating_N PF12731.2 KOO26295.1 - 0.059 13.2 1.2 0.26 11.1 0.6 2.2 1 1 1 2 2 2 0 Mating-type protein beta 1 Seadorna_VP7 PF07387.6 KOO26295.1 - 0.1 11.4 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 CENP-F_leu_zip PF10473.4 KOO26295.1 - 1.5 8.6 9.3 4.1 7.2 6.5 1.7 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PAT1 PF09770.4 KOO26295.1 - 3.4 5.7 8.6 4.4 5.4 5.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PfkB PF00294.19 KOO26297.1 - 9.2e-38 130.0 0.0 1.2e-37 129.7 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.7 KOO26297.1 - 0.00078 18.7 0.0 0.0014 17.8 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase RabGAP-TBC PF00566.13 KOO26298.1 - 3.4e-44 150.8 0.0 4.7e-44 150.4 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Ank_2 PF12796.2 KOO26300.1 - 3e-19 69.1 0.4 4.3e-14 52.6 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO26300.1 - 4.3e-15 54.6 0.0 2.7e-05 23.7 0.0 4.9 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.1 KOO26300.1 - 3.3e-08 32.9 0.1 0.0023 18.0 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.1 KOO26300.1 - 6.8e-07 29.6 0.0 0.0051 17.2 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO26300.1 - 1.7e-05 24.8 0.0 0.0042 17.2 0.0 3.6 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Tna_leader PF08053.6 KOO26300.1 - 0.16 11.3 0.2 0.32 10.3 0.1 1.5 1 0 0 1 1 1 0 Tryptophanese operon leader peptide APH PF01636.18 KOO26301.1 - 0.006 16.3 0.9 0.011 15.4 0.6 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF4440 PF14534.1 KOO26302.1 - 0.013 15.7 0.0 0.02 15.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) SnoaL_2 PF12680.2 KOO26302.1 - 0.086 13.2 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 SnoaL-like domain Na_Ca_ex PF01699.19 KOO26303.1 - 2.5e-29 101.6 12.1 1.2e-18 67.0 5.2 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein UbiA PF01040.13 KOO26303.1 - 5.2 6.2 24.1 0.3 10.2 7.9 2.7 1 1 1 2 2 2 0 UbiA prenyltransferase family DUF2215 PF10225.4 KOO26304.1 - 9.2e-13 48.2 0.2 1.4e-12 47.6 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2215) DUF2207 PF09972.4 KOO26304.1 - 0.03 12.9 0.0 0.058 11.9 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) KIAA1430 PF13879.1 KOO26305.1 - 1.1e-06 28.9 10.5 0.0018 18.6 0.0 3.6 4 0 0 4 4 4 3 KIAA1430 homologue PP2C_2 PF13672.1 KOO26306.1 - 3.2e-08 33.2 0.4 6.1e-07 29.0 0.1 2.1 2 0 0 2 2 2 1 Protein phosphatase 2C PP2C PF00481.16 KOO26306.1 - 5.9e-08 32.4 0.3 0.00057 19.3 0.0 2.5 2 1 0 2 2 2 2 Protein phosphatase 2C C2 PF00168.25 KOO26306.1 - 1e-06 28.4 0.0 2e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 C2 domain PBP1_TM PF14812.1 KOO26306.1 - 0.78 10.0 3.0 1.4 9.2 2.1 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PALP PF00291.20 KOO26308.1 - 2.7e-38 131.9 4.0 3.2e-38 131.6 2.8 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme zf-PARP PF00645.13 KOO26309.1 - 4.4e-17 62.1 0.0 7.4e-17 61.3 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region PADR1 PF08063.7 KOO26309.1 - 1.3e-06 27.7 1.9 4.7e-06 25.8 1.3 2.0 1 1 0 1 1 1 1 PADR1 (NUC008) domain TFIIF_alpha PF05793.7 KOO26309.1 - 0.009 14.4 0.9 0.012 13.9 0.6 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SAP PF02037.22 KOO26309.1 - 0.019 14.4 0.1 0.4 10.2 0.0 2.6 2 0 0 2 2 2 0 SAP domain Zn_Tnp_IS1595 PF12760.2 KOO26309.1 - 0.11 12.2 2.3 0.72 9.7 0.6 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain TerY-C PF15616.1 KOO26309.1 - 0.16 11.8 0.9 0.28 11.1 0.1 1.8 2 0 0 2 2 2 0 TerY-C metal binding domain Cpn60_TCP1 PF00118.19 KOO26310.1 - 1.4e-87 294.3 2.2 1.6e-87 294.1 1.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Senescence PF06911.7 KOO26310.1 - 0.022 14.4 1.5 0.15 11.7 0.5 2.4 2 0 0 2 2 2 0 Senescence-associated protein PAS_9 PF13426.1 KOO26311.1 - 6e-10 39.4 0.0 9e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 PAS domain PAS PF00989.19 KOO26311.1 - 0.0022 17.7 0.0 0.0033 17.1 0.0 1.3 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.5 KOO26311.1 - 0.064 13.2 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 PAS fold AAA PF00004.24 KOO26312.1 - 1.5e-26 93.1 0.0 6.9e-18 65.1 0.0 3.2 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 KOO26312.1 - 2.9e-08 34.5 0.0 0.0022 18.7 0.0 3.4 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.1 KOO26312.1 - 4.1e-08 33.4 1.2 0.0092 15.9 0.0 3.8 2 1 0 3 3 3 2 AAA ATPase domain AAA_33 PF13671.1 KOO26312.1 - 1.5e-07 31.3 0.0 0.00017 21.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 KOO26312.1 - 6.9e-07 29.4 0.1 0.00037 20.6 0.0 3.3 3 1 1 4 4 3 1 AAA domain AAA_5 PF07728.9 KOO26312.1 - 9.3e-06 25.4 0.3 0.0058 16.3 0.1 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 KOO26312.1 - 3.2e-05 24.2 0.2 0.19 12.0 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_10 PF12846.2 KOO26312.1 - 9.6e-05 21.9 0.4 0.29 10.5 0.0 2.7 3 0 0 3 3 3 2 AAA-like domain AAA_19 PF13245.1 KOO26312.1 - 0.0004 20.0 3.4 0.002 17.8 0.0 3.4 3 0 0 3 3 2 1 Part of AAA domain RuvB_N PF05496.7 KOO26312.1 - 0.00045 19.3 0.0 0.2 10.6 0.0 2.3 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 KOO26312.1 - 0.00052 19.9 0.0 0.0035 17.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 KOO26312.1 - 0.00061 18.9 0.1 0.0089 15.1 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin AAA_29 PF13555.1 KOO26312.1 - 0.0014 18.0 0.0 0.82 9.2 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain TIP49 PF06068.8 KOO26312.1 - 0.0015 17.3 0.4 0.12 11.0 0.0 2.2 2 0 0 2 2 2 1 TIP49 C-terminus IstB_IS21 PF01695.12 KOO26312.1 - 0.0019 17.6 0.1 0.22 10.9 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein APS_kinase PF01583.15 KOO26312.1 - 0.0023 17.6 0.1 0.25 10.9 0.0 2.4 2 0 0 2 2 2 1 Adenylylsulphate kinase Zot PF05707.7 KOO26312.1 - 0.0026 17.2 0.0 0.029 13.8 0.0 2.2 1 1 0 1 1 1 1 Zonular occludens toxin (Zot) RNA_helicase PF00910.17 KOO26312.1 - 0.0032 17.6 0.0 0.29 11.3 0.0 2.6 2 0 0 2 2 2 1 RNA helicase Mg_chelatase PF01078.16 KOO26312.1 - 0.0042 16.2 0.4 0.32 10.1 0.1 2.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI SMC_N PF02463.14 KOO26312.1 - 0.006 15.8 0.0 0.65 9.1 0.0 2.3 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain ABC_tran PF00005.22 KOO26312.1 - 0.0066 16.7 0.0 1.1 9.5 0.0 3.4 4 0 0 4 4 4 1 ABC transporter Rad17 PF03215.10 KOO26312.1 - 0.0068 15.1 0.0 0.17 10.5 0.0 2.1 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein SRP54 PF00448.17 KOO26312.1 - 0.0077 15.6 0.1 0.19 11.1 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Sigma54_activ_2 PF14532.1 KOO26312.1 - 0.008 16.2 0.0 0.35 10.9 0.0 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain UPF0079 PF02367.12 KOO26312.1 - 0.013 15.1 0.0 0.18 11.4 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 DnaB_bind PF10410.4 KOO26312.1 - 0.017 15.0 0.0 0.079 12.9 0.0 2.3 1 0 0 1 1 1 0 DnaB-helicase binding domain of primase NACHT PF05729.7 KOO26312.1 - 0.025 14.2 0.4 1.8 8.1 0.0 3.4 2 2 1 3 3 3 0 NACHT domain T2SE PF00437.15 KOO26312.1 - 0.049 12.5 0.0 0.26 10.1 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein ResIII PF04851.10 KOO26312.1 - 0.091 12.5 0.0 0.71 9.6 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit IPT PF01745.11 KOO26312.1 - 0.1 11.7 0.1 11 5.1 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase Sigma54_activat PF00158.21 KOO26312.1 - 0.13 11.7 0.0 2.6 7.4 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain PhoH PF02562.11 KOO26312.1 - 0.37 9.9 1.1 4 6.6 0.0 2.7 2 1 1 3 3 3 0 PhoH-like protein Helicase_C PF00271.26 KOO26316.1 - 5.9e-21 74.1 0.1 1e-20 73.3 0.1 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOO26316.1 - 6.3e-17 61.5 0.0 1.3e-16 60.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 KOO26316.1 - 0.00032 20.5 0.0 0.00053 19.8 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit MDM1 PF15501.1 KOO26317.1 - 0.14 11.0 10.2 0.31 9.9 7.0 1.5 1 0 0 1 1 1 0 Nuclear protein MDM1 V_ATPase_I PF01496.14 KOO26318.1 - 4.5e-218 725.8 0.0 5.2e-218 725.6 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family LRR_4 PF12799.2 KOO26319.1 - 1.3e-29 101.2 19.4 1.2e-08 34.4 0.2 6.9 6 2 0 6 6 6 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO26319.1 - 8.3e-25 86.3 13.2 8.8e-08 31.7 0.1 5.6 2 2 3 6 6 6 6 Leucine rich repeat LRR_1 PF00560.28 KOO26319.1 - 2e-18 63.5 9.9 0.023 14.6 0.3 9.8 11 0 0 11 11 11 5 Leucine Rich Repeat LRR_7 PF13504.1 KOO26319.1 - 7.8e-12 43.3 15.6 0.053 13.7 0.2 8.6 9 0 0 9 9 9 4 Leucine rich repeat LRR_9 PF14580.1 KOO26319.1 - 4.3e-06 26.4 0.9 0.56 9.7 0.2 3.8 1 1 3 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.1 KOO26319.1 - 0.00011 21.9 13.5 0.99 9.6 0.7 7.0 6 2 1 7 7 7 2 Leucine Rich repeat LRR_5 PF13306.1 KOO26319.1 - 0.01 15.5 0.2 2.1 8.0 0.0 3.3 2 1 0 3 3 3 0 Leucine rich repeats (6 copies) Thioredoxin PF00085.15 KOO26320.1 - 5e-31 106.4 0.0 8.8e-31 105.6 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 KOO26320.1 - 2.7e-05 24.3 0.0 0.00023 21.3 0.0 2.4 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 KOO26320.1 - 0.0019 18.2 0.1 0.055 13.6 0.0 2.7 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_7 PF13899.1 KOO26320.1 - 0.065 13.2 0.0 0.17 11.9 0.0 1.8 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin_9 PF14595.1 KOO26320.1 - 0.087 12.3 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_3 PF13192.1 KOO26320.1 - 0.14 11.9 0.0 0.5 10.2 0.0 1.9 2 0 0 2 2 2 0 Thioredoxin domain S1 PF00575.18 KOO26321.1 - 8.2e-08 32.2 2.7 0.00085 19.3 0.5 4.1 5 0 0 5 5 5 2 S1 RNA binding domain TOBE_3 PF12857.2 KOO26321.1 - 0.0017 18.1 1.7 0.0045 16.8 0.3 2.3 2 0 0 2 2 2 1 TOBE-like domain DUF1230 PF06799.6 KOO26322.1 - 4.8e-23 81.6 0.1 6.5e-23 81.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1230) UPF0104 PF03706.8 KOO26322.1 - 0.0051 16.1 0.0 0.0075 15.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0104) SET PF00856.23 KOO26324.1 - 0.00014 22.2 0.0 0.0082 16.4 0.0 2.2 1 1 0 1 1 1 1 SET domain MORN PF02493.15 KOO26324.1 - 0.007 16.0 3.1 0.007 16.0 2.2 3.1 3 0 0 3 3 3 1 MORN repeat PEP-utilisers_N PF05524.8 KOO26324.1 - 0.037 13.8 0.9 0.08 12.7 0.6 1.6 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal Methyltransf_24 PF13578.1 KOO26325.1 - 2.1e-13 50.9 0.0 4.1e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.12 KOO26325.1 - 0.0057 15.7 0.0 0.064 12.2 0.0 2.0 2 0 0 2 2 2 1 O-methyltransferase DUF2205 PF10224.4 KOO26327.1 - 0.012 15.1 0.4 0.012 15.1 0.3 4.0 5 1 0 5 5 5 0 Predicted coiled-coil protein (DUF2205) DUF3037 PF11236.3 KOO26327.1 - 1 9.4 11.3 0.13 12.3 2.1 3.5 2 2 1 3 3 3 0 Protein of unknown function (DUF3037) Pkinase PF00069.20 KOO26328.1 - 3.3e-30 105.0 0.0 4.9e-30 104.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO26328.1 - 1.7e-27 96.1 0.0 2.7e-27 95.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase zf-C3HC4_3 PF13920.1 KOO26328.1 - 1.1e-09 37.8 6.7 1.1e-09 37.8 4.6 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO26328.1 - 1.8e-06 27.8 6.2 3.9e-06 26.7 4.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO26328.1 - 0.0002 21.1 6.3 0.00054 19.7 4.4 1.8 1 0 0 1 1 1 1 Ring finger domain PDZ PF00595.19 KOO26328.1 - 0.00033 20.7 0.0 0.00091 19.3 0.0 1.7 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) zf-RING_5 PF14634.1 KOO26328.1 - 0.026 14.2 6.1 0.058 13.1 4.2 1.7 1 0 0 1 1 1 0 zinc-RING finger domain PDZ_2 PF13180.1 KOO26328.1 - 0.038 13.8 0.0 0.082 12.8 0.0 1.5 1 0 0 1 1 1 0 PDZ domain Ank PF00023.25 KOO26331.1 - 8.8e-22 75.7 10.4 7.5e-09 34.9 0.0 5.8 5 0 0 5 5 5 4 Ankyrin repeat Ank_2 PF12796.2 KOO26331.1 - 1.2e-21 76.8 7.8 1.7e-11 44.3 0.1 3.7 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO26331.1 - 1.9e-18 64.6 4.5 6e-06 25.9 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.1 KOO26331.1 - 2.4e-17 62.5 16.2 6.3e-07 29.4 0.0 6.5 4 1 3 7 7 7 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO26331.1 - 4.7e-13 49.2 6.4 5.9e-08 33.0 0.0 3.4 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ion_trans PF00520.26 KOO26331.1 - 1.5e-12 47.2 8.7 2.7e-12 46.3 6.0 1.3 1 0 0 1 1 1 1 Ion transport protein BIV_Env PF05858.7 KOO26331.1 - 0.76 7.6 2.9 1.1 7.0 2.0 1.2 1 0 0 1 1 1 0 Bovine immunodeficiency virus surface protein (SU) PDEase_I PF00233.14 KOO26332.1 - 1e-67 228.3 0.1 3.9e-67 226.4 0.1 1.8 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase Ion_trans PF00520.26 KOO26332.1 - 1.1e-10 41.1 4.2 2e-10 40.2 2.9 1.4 1 0 0 1 1 1 1 Ion transport protein PUB PF09409.5 KOO26333.1 - 3.6e-17 61.9 0.0 6.2e-17 61.1 0.0 1.5 1 1 0 1 1 1 1 PUB domain DUF4478 PF14793.1 KOO26334.1 - 0.009 15.6 1.7 18 4.9 0.0 4.9 5 0 0 5 5 5 3 Domain of unknown function (DUF4478) Transglut_core2 PF13369.1 KOO26335.1 - 6.6e-40 136.0 0.1 1.6e-39 134.7 0.0 1.7 1 0 0 1 1 1 1 Transglutaminase-like superfamily Ank_2 PF12796.2 KOO26335.1 - 8.6e-12 45.2 0.1 2.2e-11 43.9 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO26335.1 - 5.3e-09 36.3 0.0 5.8e-05 23.4 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO26335.1 - 7e-09 35.6 0.0 2.2e-07 30.8 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO26335.1 - 1.2e-08 34.3 0.0 3.4e-08 32.8 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.1 KOO26335.1 - 1.2e-06 28.1 0.0 8e-06 25.6 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat F-box-like PF12937.2 KOO26335.1 - 0.00011 21.8 0.2 0.00043 19.9 0.2 2.1 1 0 0 1 1 1 1 F-box-like AAA PF00004.24 KOO26336.1 - 2.9e-23 82.5 0.0 4.3e-23 81.9 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 KOO26336.1 - 1.6e-06 27.9 0.0 4.2e-06 26.5 0.0 1.7 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain Neur_chan_memb PF02932.11 KOO26337.1 - 1.7e-07 31.4 0.0 3.2e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region EF-hand_1 PF00036.27 KOO26338.1 - 3.2e-10 38.5 3.7 0.031 13.5 0.0 4.2 3 1 1 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO26338.1 - 2e-08 34.2 2.3 0.00022 21.3 1.5 3.0 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO26338.1 - 4.5e-07 29.2 2.2 0.011 15.5 0.0 3.8 3 1 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 KOO26338.1 - 0.00053 19.5 0.2 0.0052 16.3 0.0 2.6 2 1 1 3 3 3 1 EF-hand domain pair PAN_4 PF14295.1 KOO26339.1 - 0.097 12.3 13.3 0.62 9.8 9.2 2.4 1 1 0 1 1 1 0 PAN domain Xpo1 PF08389.7 KOO26340.1 - 4.9e-22 78.4 0.0 1.1e-21 77.2 0.0 1.7 1 0 0 1 1 1 1 Exportin 1-like protein MinE PF03776.9 KOO26340.1 - 0.19 11.2 0.0 0.48 9.9 0.0 1.7 1 0 0 1 1 1 0 Septum formation topological specificity factor MinE ABC2_membrane PF01061.19 KOO26342.1 - 7.3e-42 142.9 17.5 1.2e-41 142.2 12.2 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.22 KOO26342.1 - 1.4e-23 83.7 0.0 2e-23 83.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 KOO26342.1 - 4.6e-08 33.3 0.0 0.0016 18.4 0.0 2.2 2 0 0 2 2 2 2 AAA domain ABC2_membrane_3 PF12698.2 KOO26342.1 - 6.2e-05 22.1 15.4 6.2e-05 22.1 10.7 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein SMC_N PF02463.14 KOO26342.1 - 0.00018 20.8 0.0 0.00061 19.0 0.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 KOO26342.1 - 0.0011 18.9 0.3 0.0032 17.4 0.0 1.9 2 1 0 2 2 1 1 AAA ATPase domain DUF258 PF03193.11 KOO26342.1 - 0.0012 18.1 0.0 0.0019 17.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_25 PF13481.1 KOO26342.1 - 0.0052 16.1 0.0 0.029 13.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KOO26342.1 - 0.0065 16.2 0.2 0.12 12.1 0.0 2.8 2 0 0 2 2 2 1 Part of AAA domain Arch_ATPase PF01637.13 KOO26342.1 - 0.007 16.0 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 Archaeal ATPase AAA_22 PF13401.1 KOO26342.1 - 0.0077 16.3 0.0 0.03 14.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain T2SE PF00437.15 KOO26342.1 - 0.015 14.2 0.0 0.03 13.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_29 PF13555.1 KOO26342.1 - 0.015 14.8 0.0 0.034 13.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.13 KOO26342.1 - 0.015 14.7 0.1 0.17 11.3 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_17 PF13207.1 KOO26342.1 - 0.028 15.2 0.0 0.12 13.2 0.0 2.1 2 0 0 2 2 1 0 AAA domain AAA_10 PF12846.2 KOO26342.1 - 0.056 12.8 0.1 0.096 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain cobW PF02492.14 KOO26342.1 - 0.071 12.5 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain SbcCD_C PF13558.1 KOO26342.1 - 0.077 12.9 0.1 0.72 9.8 0.1 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit SRP54 PF00448.17 KOO26342.1 - 0.082 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_28 PF13521.1 KOO26342.1 - 0.087 12.7 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 KOO26342.1 - 0.11 12.7 0.0 0.69 10.1 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 KOO26342.1 - 0.12 12.0 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.1 KOO26342.1 - 0.25 11.6 0.0 0.56 10.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 KOO26342.1 - 0.26 10.8 0.0 0.53 9.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC2_membrane_2 PF12679.2 KOO26342.1 - 0.75 8.6 9.1 0.045 12.6 2.4 1.7 2 0 0 2 2 2 0 ABC-2 family transporter protein LRR_5 PF13306.1 KOO26344.1 - 1.5e-137 451.5 0.1 5.7e-38 129.5 0.1 3.5 1 1 3 4 4 4 4 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO26344.1 - 2e-44 149.1 7.1 1.9e-08 33.9 0.0 7.3 1 1 7 8 8 8 8 Leucine rich repeat ZF-HD_dimer PF04770.7 KOO26344.1 - 0.17 11.9 12.6 22 5.2 0.1 5.9 5 1 1 6 6 6 0 ZF-HD protein dimerisation region TPR_11 PF13414.1 KOO26346.1 - 2e-09 36.9 0.4 0.00047 19.7 0.0 2.2 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 KOO26346.1 - 0.00073 19.2 0.1 0.33 10.9 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO26346.1 - 0.031 13.8 0.1 1.9 8.2 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 KOO26346.1 - 0.045 14.0 0.7 4.2 7.7 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Pyr_redox_2 PF07992.9 KOO26347.1 - 2.6e-38 131.9 0.0 4.2e-38 131.2 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 KOO26347.1 - 1.6e-28 98.8 0.3 4.6e-28 97.4 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 KOO26347.1 - 5.1e-16 58.8 0.9 6.2e-12 45.7 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOO26347.1 - 7.9e-09 35.8 0.0 1.8e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 KOO26347.1 - 1.8e-08 33.6 2.6 2.9e-06 26.4 0.3 3.2 2 1 2 4 4 4 1 FAD binding domain DAO PF01266.19 KOO26347.1 - 8.6e-05 21.5 1.0 0.00069 18.6 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.2 KOO26347.1 - 0.0001 21.5 0.1 0.00016 20.8 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 KOO26347.1 - 0.0017 17.4 0.1 0.0034 16.5 0.1 1.5 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.9 KOO26347.1 - 0.0039 15.7 3.6 0.0079 14.7 0.4 2.6 3 1 1 4 4 4 1 HI0933-like protein GIDA PF01134.17 KOO26347.1 - 0.0044 15.9 2.6 0.0082 15.0 1.8 1.6 1 1 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.1 KOO26347.1 - 0.012 15.5 1.0 0.033 14.2 0.7 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Cyd_oper_YbgE PF09600.5 KOO26347.1 - 0.19 11.8 0.2 0.42 10.8 0.1 1.5 1 0 0 1 1 1 0 Cyd operon protein YbgE (Cyd_oper_YbgE) NAD_binding_10 PF13460.1 KOO26349.1 - 5.2e-22 78.7 0.0 5.5e-21 75.3 0.0 2.1 1 1 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 KOO26349.1 - 1.5e-08 34.2 0.0 2.4e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.20 KOO26349.1 - 5.5e-07 29.6 0.7 1e-06 28.7 0.5 1.5 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOO26349.1 - 1.3e-05 24.8 0.4 2.6e-05 23.9 0.3 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.7 KOO26349.1 - 3.3e-05 22.9 0.2 0.011 14.6 0.1 3.0 2 1 0 2 2 2 1 Male sterility protein 3Beta_HSD PF01073.14 KOO26349.1 - 0.00025 19.8 0.0 0.0004 19.1 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 KOO26349.1 - 0.028 13.8 0.0 0.076 12.4 0.0 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family LRR_6 PF13516.1 KOO26350.1 - 2e-16 58.1 1.8 0.011 15.7 0.0 6.7 6 0 0 6 6 6 3 Leucine Rich repeat LRR_4 PF12799.2 KOO26350.1 - 4e-05 23.1 0.1 3.7 7.2 0.0 5.1 2 2 4 6 6 6 3 Leucine Rich repeats (2 copies) EF-hand_6 PF13405.1 KOO26350.1 - 0.00058 19.5 0.0 0.0018 17.9 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 KOO26350.1 - 0.0012 18.9 0.0 0.0035 17.4 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO26350.1 - 0.0017 17.5 0.0 0.0053 15.9 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.1 KOO26350.1 - 0.0022 17.2 0.0 0.0049 16.1 0.0 1.6 1 0 0 1 1 1 1 EF hand LRR_7 PF13504.1 KOO26350.1 - 0.0036 17.2 5.4 75 4.2 0.0 6.0 6 0 0 6 6 6 0 Leucine rich repeat Peripla_BP_3 PF13377.1 KOO26350.1 - 0.008 16.1 0.1 0.033 14.2 0.0 2.1 2 0 0 2 2 2 1 Periplasmic binding protein-like domain LRR_8 PF13855.1 KOO26350.1 - 0.025 14.3 6.1 2.1 8.1 0.2 4.9 4 2 0 4 4 4 0 Leucine rich repeat Arm PF00514.18 KOO26351.1 - 2.1e-09 36.8 7.5 0.00069 19.3 0.5 4.8 4 0 0 4 4 4 4 Armadillo/beta-catenin-like repeat Ion_trans PF00520.26 KOO26352.1 - 6.4e-15 54.9 3.9 6.4e-15 54.9 2.7 1.7 2 0 0 2 2 2 1 Ion transport protein Ion_trans_2 PF07885.11 KOO26352.1 - 3.9e-11 42.5 0.5 3.9e-11 42.5 0.4 2.2 2 0 0 2 2 2 1 Ion channel cNMP_binding PF00027.24 KOO26352.1 - 7.7e-11 41.6 0.0 2.8e-10 39.8 0.0 2.0 2 1 0 2 2 2 1 Cyclic nucleotide-binding domain Ion_trans_N PF08412.5 KOO26352.1 - 0.0012 18.1 0.0 0.0038 16.4 0.0 1.8 1 0 0 1 1 1 1 Ion transport protein N-terminal DUF3911 PF13050.1 KOO26352.1 - 0.087 12.9 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3911) O-FucT PF10250.4 KOO26353.1 - 0.00045 19.4 0.1 0.0019 17.4 0.0 1.7 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase FliL PF03748.9 KOO26354.1 - 0.011 15.7 0.9 0.023 14.6 0.6 1.6 1 0 0 1 1 1 0 Flagellar basal body-associated protein FliL PSD4 PF07631.6 KOO26354.1 - 0.016 15.5 2.1 0.033 14.5 1.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1592) DnaI_N PF07319.6 KOO26354.1 - 0.057 13.6 1.8 0.097 12.9 1.2 1.4 1 0 0 1 1 1 0 Primosomal protein DnaI N-terminus DUF445 PF04286.7 KOO26354.1 - 0.074 12.5 0.0 0.091 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) T2SG PF08334.6 KOO26354.1 - 0.11 12.2 0.1 0.2 11.4 0.1 1.5 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein G ING PF12998.2 KOO26355.1 - 0.0059 16.8 1.4 0.0059 16.8 1.0 3.0 2 1 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding Rpn3_C PF08375.6 KOO26356.1 - 4.9e-22 78.1 0.3 1.1e-21 76.9 0.2 1.7 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal PCI PF01399.22 KOO26356.1 - 1.3e-19 70.4 0.0 2.7e-19 69.4 0.0 1.6 1 0 0 1 1 1 1 PCI domain TPR_12 PF13424.1 KOO26356.1 - 0.0051 16.7 4.4 0.019 14.8 3.0 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO26356.1 - 2.8 8.0 7.7 0.15 12.0 0.3 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat UDP-g_GGTase PF06427.6 KOO26357.1 - 2.1e-51 174.2 0.0 3e-51 173.7 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.15 KOO26357.1 - 1.9e-06 27.3 0.2 3.6e-06 26.4 0.2 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 DUF924 PF06041.6 KOO26358.1 - 5.4e-40 137.1 0.0 7.5e-40 136.6 0.0 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) GST_N PF02798.15 KOO26358.1 - 1.5e-08 34.6 0.0 3.1e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 KOO26358.1 - 4.6e-05 23.8 0.0 0.00011 22.6 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 KOO26358.1 - 0.00082 19.5 0.0 0.0021 18.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KOO26358.1 - 0.0051 16.6 0.0 0.014 15.2 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 KOO26358.1 - 0.052 13.5 0.1 0.13 12.2 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Prefoldin PF02996.12 KOO26360.1 - 1.3e-27 95.8 2.5 1.7e-27 95.4 1.8 1.2 1 0 0 1 1 1 1 Prefoldin subunit priB_priC PF07445.7 KOO26360.1 - 0.02 14.3 2.0 0.11 12.0 0.0 2.0 2 0 0 2 2 2 0 Primosomal replication protein priB and priC DUF1664 PF07889.7 KOO26360.1 - 0.042 13.6 1.4 6.9 6.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) LRR_4 PF12799.2 KOO26360.1 - 0.07 12.7 2.0 0.14 11.8 1.4 1.5 1 0 0 1 1 1 0 Leucine Rich repeats (2 copies) Baculo_PEP_C PF04513.7 KOO26360.1 - 0.074 12.8 3.2 0.22 11.3 0.5 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FlxA PF14282.1 KOO26360.1 - 0.085 12.8 8.3 0.077 12.9 1.5 2.1 2 0 0 2 2 2 0 FlxA-like protein DUF4140 PF13600.1 KOO26360.1 - 0.15 12.5 2.7 0.83 10.1 0.6 2.2 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Spc24 PF08286.6 KOO26360.1 - 0.17 11.6 5.5 0.1 12.3 0.7 2.0 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 HrpB7 PF09486.5 KOO26360.1 - 0.2 11.5 5.5 0.82 9.5 0.1 2.3 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) ING PF12998.2 KOO26360.1 - 0.4 10.9 3.1 1.2 9.4 0.3 2.3 2 1 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Utp8 PF10395.4 KOO26360.1 - 0.45 8.7 4.6 1 7.5 3.2 1.7 1 1 0 1 1 1 0 Utp8 family Spectrin PF00435.16 KOO26360.1 - 0.62 10.3 6.8 2.2 8.6 1.1 2.1 2 0 0 2 2 2 0 Spectrin repeat Prefoldin_2 PF01920.15 KOO26360.1 - 1.1 9.0 9.5 16 5.3 0.1 2.7 2 1 0 2 2 2 0 Prefoldin subunit Tropomyosin_1 PF12718.2 KOO26360.1 - 1.9 8.3 9.2 4.5 7.1 2.5 2.2 2 0 0 2 2 2 0 Tropomyosin like YscO PF07321.7 KOO26360.1 - 2 8.2 8.5 0.54 10.0 1.4 2.1 2 0 0 2 2 2 0 Type III secretion protein YscO Cyclin_N PF00134.18 KOO26361.1 - 1.6e-09 37.3 0.8 2.2e-09 36.9 0.1 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Arm PF00514.18 KOO26362.1 - 4.3e-08 32.6 11.7 0.0002 21.0 0.0 5.4 5 1 0 5 5 5 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 KOO26362.1 - 0.91 10.1 10.2 6.4 7.3 0.5 4.6 5 0 0 5 5 5 0 HEAT-like repeat HEAT_2 PF13646.1 KOO26362.1 - 4.5 7.6 10.0 21 5.5 5.5 2.9 2 1 0 2 2 2 0 HEAT repeats Noc2 PF03715.8 KOO26363.1 - 5.2e-57 192.9 1.5 5.6e-35 120.6 0.0 2.0 1 1 1 2 2 2 2 Noc2p family MFS_1 PF07690.11 KOO26364.1 - 3.8e-10 39.0 19.1 5e-10 38.6 13.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4140 PF13600.1 KOO26364.1 - 0.87 10.0 6.3 46 4.5 4.0 3.0 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) CRAL_TRIO PF00650.15 KOO26366.1 - 5.2e-27 94.2 0.0 6.6e-27 93.9 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.1 KOO26366.1 - 0.0043 16.9 0.0 0.0094 15.8 0.0 1.6 1 1 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.10 KOO26366.1 - 0.088 12.9 0.0 0.29 11.2 0.0 1.9 2 0 0 2 2 2 0 CRAL/TRIO, N-terminal domain PH PF00169.24 KOO26367.1 - 5e-18 65.2 0.0 6.7e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 KOO26367.1 - 5.6e-07 29.7 0.1 5.9e-05 23.2 0.1 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_4 PF15404.1 KOO26367.1 - 0.00047 19.7 0.1 0.34 10.4 0.0 2.4 1 1 0 2 2 2 2 Pleckstrin homology domain PH_3 PF14593.1 KOO26367.1 - 0.00079 19.2 0.0 0.0043 16.9 0.0 1.9 1 1 0 1 1 1 1 PH domain PH_9 PF15410.1 KOO26367.1 - 0.0024 18.0 0.0 0.0053 16.9 0.0 1.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.1 KOO26367.1 - 0.1 12.6 0.1 0.18 11.8 0.0 1.6 2 0 0 2 2 2 0 Pleckstrin homology domain COPIIcoated_ERV PF07970.7 KOO26368.1 - 4.9e-27 94.9 0.0 1e-26 93.9 0.0 1.6 2 0 0 2 2 2 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 KOO26368.1 - 1.3e-24 86.0 0.8 2.9e-24 84.8 0.5 1.6 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Thioredoxin PF00085.15 KOO26368.1 - 2.4e-18 65.7 0.0 5.1e-18 64.6 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 KOO26368.1 - 0.0022 18.1 0.1 0.0061 16.7 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 KOO26368.1 - 0.13 12.4 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like Mito_carr PF00153.22 KOO26371.1 - 5e-60 199.2 2.1 4.1e-20 71.2 0.1 3.6 3 0 0 3 3 3 3 Mitochondrial carrier protein FTCD_C PF04961.7 KOO26371.1 - 0.53 9.6 10.4 0.16 11.3 4.0 2.3 1 1 1 2 2 2 0 Formiminotransferase-cyclodeaminase Fib_alpha PF08702.5 KOO26371.1 - 1.1 9.3 9.9 1.4 9.0 6.2 1.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF3176 PF11374.3 KOO26373.1 - 0.0011 18.7 4.1 0.0024 17.7 0.7 2.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3176) MerT PF02411.10 KOO26374.1 - 0.021 14.6 0.4 0.91 9.3 0.0 2.6 2 0 0 2 2 2 0 MerT mercuric transport protein Autophagy_N PF03986.8 KOO26375.1 - 4.2e-43 146.6 0.0 5.6e-43 146.2 0.0 1.2 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.10 KOO26375.1 - 2.6e-20 72.3 0.2 2.6e-19 69.1 0.1 2.4 2 0 0 2 2 2 1 Autophagocytosis associated protein, active-site domain Autophagy_Cterm PF10381.4 KOO26375.1 - 1.1e-13 50.0 0.6 1.7e-13 49.3 0.4 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Actin PF00022.14 KOO26376.1 - 4e-91 305.3 0.0 5e-91 305.0 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 KOO26376.1 - 0.00027 19.6 0.0 0.085 11.4 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein RE_SinI PF09570.5 KOO26376.1 - 0.026 13.5 0.0 0.061 12.3 0.0 1.6 2 0 0 2 2 2 0 SinI restriction endonuclease DUF3597 PF12200.3 KOO26376.1 - 8.7 6.7 8.9 20 5.5 1.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3597) ThiF PF00899.16 KOO26377.1 - 6.6e-47 158.7 5.7 1.1e-28 99.6 0.0 3.0 3 0 0 3 3 3 2 ThiF family UBA_e1_C PF09358.5 KOO26377.1 - 3.3e-43 146.8 0.0 6e-43 145.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme e1 C-terminal domain UBACT PF02134.16 KOO26377.1 - 4.6e-43 144.6 1.1 3.1e-27 93.9 0.4 2.9 3 0 0 3 3 3 2 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 KOO26377.1 - 1.8e-26 91.2 0.4 3.6e-22 77.4 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin-activating enzyme active site LETM1 PF07766.8 KOO26378.1 - 1.8e-27 96.0 0.0 3.1e-14 52.6 0.0 2.1 2 0 0 2 2 2 2 LETM1-like protein UVR PF02151.14 KOO26380.1 - 9.1e-05 21.8 4.9 0.00023 20.5 3.0 2.0 1 1 0 1 1 1 1 UvrB/uvrC motif ERp29 PF07749.7 KOO26380.1 - 0.018 15.6 1.3 0.053 14.1 0.1 2.1 2 1 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain Rsd_AlgQ PF04353.8 KOO26380.1 - 0.12 12.0 2.6 6.1 6.5 0.1 3.0 1 1 2 3 3 3 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ DUF1311 PF07007.7 KOO26380.1 - 0.26 11.3 4.0 0.48 10.5 2.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1311) TPM PF04536.9 KOO26381.1 - 0.0079 16.0 0.3 0.016 15.0 0.1 1.7 2 0 0 2 2 2 1 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase cNMP_binding PF00027.24 KOO26382.1 - 4.8e-10 39.1 0.0 4.8e-07 29.4 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain IZUMO PF15005.1 KOO26382.1 - 0.57 10.2 13.4 0.068 13.2 1.5 2.9 2 1 1 3 3 3 0 Izumo sperm-egg fusion PP2C PF00481.16 KOO26383.1 - 2e-50 171.5 0.0 2.8e-33 115.3 0.0 3.1 3 0 0 3 3 3 3 Protein phosphatase 2C BTB PF00651.26 KOO26383.1 - 2.1e-24 85.6 0.0 7.7e-24 83.8 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain NHL PF01436.16 KOO26383.1 - 1.3e-17 62.7 10.4 7.5e-06 25.6 0.0 5.2 5 0 0 5 5 5 4 NHL repeat SGL PF08450.7 KOO26383.1 - 2.2e-10 40.3 0.8 0.029 13.7 0.0 4.5 2 1 2 4 4 4 4 SMP-30/Gluconolaconase/LRE-like region SBBP PF06739.6 KOO26383.1 - 1.6e-05 24.6 1.8 0.15 11.8 0.0 3.4 3 0 0 3 3 3 2 Beta-propeller repeat DUF839 PF05787.8 KOO26383.1 - 0.00075 18.5 1.6 0.59 9.0 0.1 3.1 1 1 3 4 4 4 2 Bacterial protein of unknown function (DUF839) DUF3342 PF11822.3 KOO26383.1 - 0.28 10.2 0.0 1.6 7.7 0.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF3342) Pro_isomerase PF00160.16 KOO26384.1 - 7.4e-44 149.6 0.1 9.8e-44 149.2 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Zeta_toxin PF06414.7 KOO26385.1 - 1.1e-13 50.7 0.0 1.8e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.1 KOO26385.1 - 1.8e-07 31.1 0.0 2.8e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO26385.1 - 1.5e-05 25.7 0.1 4.3e-05 24.3 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 KOO26385.1 - 0.042 14.1 0.1 0.13 12.6 0.0 1.9 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.1 KOO26385.1 - 0.05 13.7 0.0 0.13 12.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain cobW PF02492.14 KOO26385.1 - 0.12 11.8 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_19 PF13245.1 KOO26385.1 - 0.13 12.0 0.2 0.47 10.2 0.1 1.9 1 1 0 1 1 1 0 Part of AAA domain Viral_helicase1 PF01443.13 KOO26385.1 - 0.13 11.8 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase LUC7 PF03194.10 KOO26387.1 - 7.1e-22 78.1 0.2 9.6e-22 77.7 0.1 1.1 1 0 0 1 1 1 1 LUC7 N_terminus DUF4200 PF13863.1 KOO26387.1 - 0.059 13.3 6.3 0.082 12.8 4.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) FlxA PF14282.1 KOO26387.1 - 0.059 13.3 0.8 0.059 13.3 0.5 1.6 2 0 0 2 2 2 0 FlxA-like protein MIS13 PF08202.6 KOO26387.1 - 0.068 12.2 0.4 0.092 11.8 0.3 1.1 1 0 0 1 1 1 0 Mis12-Mtw1 protein family DUF3106 PF11304.3 KOO26387.1 - 0.19 12.1 1.5 0.39 11.1 1.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3106) Sec2p PF06428.6 KOO26387.1 - 0.43 10.4 3.8 0.58 10.0 2.7 1.2 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p MORN PF02493.15 KOO26388.1 - 1.5e-30 103.0 42.4 2.7e-07 29.9 2.6 7.4 7 0 0 7 7 7 7 MORN repeat EF-hand_7 PF13499.1 KOO26388.1 - 0.002 18.2 0.0 0.0092 16.0 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO26388.1 - 0.065 13.1 0.0 0.25 11.3 0.0 2.0 1 0 0 1 1 1 0 EF-hand domain O-FucT PF10250.4 KOO26389.1 - 1.6e-25 89.9 0.0 4.8e-16 58.8 0.0 2.1 2 0 0 2 2 2 2 GDP-fucose protein O-fucosyltransferase MM_CoA_mutase PF01642.17 KOO26390.1 - 1.3e-220 732.8 0.7 1.6e-220 732.6 0.5 1.1 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase B12-binding PF02310.14 KOO26390.1 - 4.7e-16 58.7 0.7 1.9e-15 56.8 0.5 2.0 1 0 0 1 1 1 1 B12 binding domain Aminotran_5 PF00266.14 KOO26391.1 - 1.3e-146 488.1 0.1 1.6e-146 487.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 KOO26391.1 - 1.1e-08 34.5 0.5 2.3e-05 23.6 0.2 2.2 2 0 0 2 2 2 2 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.15 KOO26391.1 - 6.6e-05 21.3 0.0 0.00019 19.8 0.0 1.5 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.16 KOO26391.1 - 8.2e-05 21.8 0.1 0.00012 21.3 0.1 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase RVT_2 PF07727.9 KOO26393.1 - 8.6e-05 21.6 0.0 0.0001 21.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PDZ PF00595.19 KOO26394.1 - 8.2e-05 22.7 0.0 0.00011 22.3 0.0 1.2 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO26394.1 - 0.051 13.4 0.0 0.072 12.9 0.0 1.3 1 0 0 1 1 1 0 PDZ domain Arm PF00514.18 KOO26395.1 - 6.5e-25 86.0 39.4 0.0037 17.0 0.7 15.7 15 1 0 15 15 15 9 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO26395.1 - 1.6e-05 25.0 60.1 0.0095 16.1 1.6 10.2 4 4 6 10 10 10 5 HEAT repeats V-ATPase_H_N PF03224.9 KOO26395.1 - 0.00069 18.8 2.8 0.22 10.6 0.7 4.3 2 1 0 2 2 2 1 V-ATPase subunit H Arm_2 PF04826.8 KOO26395.1 - 0.012 14.6 0.6 13 4.8 0.0 3.7 3 1 1 4 4 4 0 Armadillo-like CTNNBL PF08216.6 KOO26395.1 - 0.022 14.3 1.6 2.8 7.5 0.1 3.9 3 1 1 4 4 4 0 Catenin-beta-like, Arm-motif containing nuclear KorB PF08535.5 KOO26395.1 - 0.042 14.0 0.2 0.83 9.8 0.1 2.9 2 0 0 2 2 2 0 KorB domain RTTN_N PF14726.1 KOO26395.1 - 1.1 9.9 5.0 6.1 7.4 0.5 4.0 3 1 1 4 4 4 0 Rotatin, an armadillo repeat protein, centriole functioning Fasciclin PF02469.17 KOO26396.1 - 2.1e-35 121.4 0.0 4.1e-35 120.5 0.0 1.5 1 0 0 1 1 1 1 Fasciclin domain PAP_fibrillin PF04755.7 KOO26396.1 - 1.9e-15 57.1 0.0 1.6e-07 31.2 0.0 2.5 2 0 0 2 2 2 2 PAP_fibrillin CH PF00307.26 KOO26397.1 - 1.8e-08 34.3 0.0 2.9e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain Mnd1 PF03962.10 KOO26397.1 - 3 7.4 4.7 4.6 6.8 3.2 1.2 1 0 0 1 1 1 0 Mnd1 family DUF4118 PF13493.1 KOO26398.1 - 0.018 15.2 5.9 0.031 14.4 4.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4118) DUF3094 PF11293.3 KOO26398.1 - 0.03 13.7 0.5 0.064 12.7 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3094) MRAP PF15183.1 KOO26398.1 - 0.075 12.6 2.1 0.18 11.4 1.5 1.7 1 1 0 1 1 1 0 Melanocortin-2 receptor accessory protein family Glyco_hydro_2_N PF02837.13 KOO26399.1 - 1.6e-38 131.9 0.0 2.1e-38 131.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.12 KOO26399.1 - 9.1e-20 70.7 0.1 1.3e-19 70.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Cellulase-like PF12876.2 KOO26399.1 - 1.2e-06 28.8 0.1 2.4e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Sugar-binding cellulase-like BetaGal_dom4_5 PF13364.1 KOO26399.1 - 2.8e-05 24.3 0.1 8.9e-05 22.7 0.0 1.8 2 0 0 2 2 2 1 Beta-galactosidase jelly roll domain Glyco_hydro_2 PF00703.16 KOO26399.1 - 0.12 12.7 0.0 0.23 11.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 2 Mito_fiss_reg PF05308.6 KOO26400.1 - 0.071 12.4 11.0 0.018 14.3 3.3 2.2 1 1 0 2 2 2 0 Mitochondrial fission regulator Asp-B-Hydro_N PF05279.6 KOO26400.1 - 0.51 10.1 7.6 0.75 9.5 5.3 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region PC-Esterase PF13839.1 KOO26401.1 - 0.00016 21.5 0.0 0.00019 21.3 0.0 1.1 1 0 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p Hint PF01079.15 KOO26403.1 - 2.4e-24 85.7 0.0 3.1e-24 85.4 0.0 1.0 1 0 0 1 1 1 1 Hint module Hint_2 PF13403.1 KOO26403.1 - 0.025 14.5 0.0 0.078 12.9 0.0 1.9 1 1 0 1 1 1 0 Hint domain Peptidase_C2 PF00648.16 KOO26404.1 - 2.8e-54 184.1 0.0 4.2e-54 183.5 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease GAF PF01590.21 KOO26404.1 - 2.1e-05 24.7 0.3 0.00028 21.0 0.0 2.7 2 0 0 2 2 2 1 GAF domain Ax_dynein_light PF10211.4 KOO26404.1 - 0.082 12.7 2.3 0.14 12.0 1.6 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain Calpain_III PF01067.17 KOO26404.1 - 0.18 11.4 0.0 0.36 10.4 0.0 1.4 1 0 0 1 1 1 0 Calpain large subunit, domain III AAA PF00004.24 KOO26406.1 - 1.8e-39 134.9 0.0 3e-39 134.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 KOO26406.1 - 1.2e-06 27.7 0.0 2.1e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KOO26406.1 - 5.5e-06 26.5 0.2 0.00016 21.8 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOO26406.1 - 0.00011 21.8 0.1 0.0011 18.6 0.0 2.7 2 0 0 2 2 2 1 Part of AAA domain AAA_17 PF13207.1 KOO26406.1 - 0.00017 22.4 0.0 0.00045 21.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.8 KOO26406.1 - 0.00026 19.8 0.0 0.00039 19.2 0.0 1.1 1 0 0 1 1 1 1 TIP49 C-terminus AAA_5 PF07728.9 KOO26406.1 - 0.00032 20.4 0.0 0.0012 18.5 0.0 2.1 3 0 0 3 3 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOO26406.1 - 0.00036 20.5 0.6 0.0015 18.5 0.1 2.5 2 1 0 2 2 2 1 AAA ATPase domain Vps4_C PF09336.5 KOO26406.1 - 0.00098 18.9 0.0 0.002 17.9 0.0 1.5 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain IstB_IS21 PF01695.12 KOO26406.1 - 0.0011 18.3 0.0 0.0029 17.0 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_24 PF13479.1 KOO26406.1 - 0.0016 18.0 0.0 0.0035 16.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 KOO26406.1 - 0.0042 16.9 0.0 0.0083 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 KOO26406.1 - 0.0056 16.8 0.0 0.011 15.9 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.1 KOO26406.1 - 0.006 16.8 0.1 0.017 15.3 0.0 1.9 2 1 0 2 2 1 1 AAA domain Mg_chelatase PF01078.16 KOO26406.1 - 0.0064 15.6 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 KOO26406.1 - 0.0073 15.7 2.3 0.069 12.5 0.2 3.0 2 1 1 3 3 3 1 AAA domain KaiC PF06745.8 KOO26406.1 - 0.015 14.4 0.1 0.56 9.2 0.0 2.2 1 1 1 2 2 2 0 KaiC Sigma54_activat PF00158.21 KOO26406.1 - 0.016 14.6 0.0 0.52 9.7 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_14 PF13173.1 KOO26406.1 - 0.022 14.6 0.0 0.042 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain LisH PF08513.6 KOO26406.1 - 0.024 14.4 0.0 0.057 13.2 0.0 1.6 1 0 0 1 1 1 0 LisH AAA_11 PF13086.1 KOO26406.1 - 0.033 13.7 0.0 0.056 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 KOO26406.1 - 0.036 13.3 0.0 0.069 12.3 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein DUF815 PF05673.8 KOO26406.1 - 0.036 12.9 0.0 0.059 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NACHT PF05729.7 KOO26406.1 - 0.039 13.6 0.0 0.39 10.3 0.0 2.3 1 1 1 2 2 2 0 NACHT domain AAA_28 PF13521.1 KOO26406.1 - 0.04 13.8 0.0 0.089 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.12 KOO26406.1 - 0.065 12.0 0.1 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_3 PF07726.6 KOO26406.1 - 0.098 12.2 0.0 0.27 10.8 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.7 KOO26406.1 - 0.11 11.5 0.0 0.23 10.5 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Bac_DnaA PF00308.13 KOO26406.1 - 0.15 11.6 0.0 0.32 10.5 0.0 1.5 1 1 0 1 1 1 0 Bacterial dnaA protein DUF2075 PF09848.4 KOO26406.1 - 0.18 10.7 0.0 0.28 10.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NB-ARC PF00931.17 KOO26406.1 - 0.21 10.3 0.0 0.31 9.8 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain Spore_YtfJ PF09579.5 KOO26406.1 - 0.86 9.5 3.2 1.7 8.5 2.3 1.4 1 0 0 1 1 1 0 Sporulation protein YtfJ (Spore_YtfJ) 2-Hacid_dh_C PF02826.14 KOO26409.1 - 1.8e-36 124.9 0.0 9.2e-23 80.3 0.0 2.1 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 KOO26409.1 - 1.8e-11 43.6 0.0 2e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 KOO26409.1 - 0.0026 17.6 0.0 0.0052 16.6 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ThiF PF00899.16 KOO26409.1 - 0.0054 16.5 1.3 0.011 15.5 0.9 1.4 1 0 0 1 1 1 1 ThiF family F420_oxidored PF03807.12 KOO26409.1 - 0.017 15.4 0.0 0.044 14.2 0.0 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.7 KOO26409.1 - 0.031 13.6 0.0 0.059 12.7 0.0 1.5 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain TrkA_N PF02254.13 KOO26409.1 - 0.13 12.2 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain CS PF04969.11 KOO26411.1 - 6.2e-08 33.0 0.2 9.6e-08 32.4 0.1 1.2 1 0 0 1 1 1 1 CS domain PBP1_TM PF14812.1 KOO26411.1 - 0.036 14.3 4.9 0.32 11.3 3.4 2.1 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM60A PF15396.1 KOO26411.1 - 0.045 13.5 2.1 0.065 12.9 1.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A NARP1 PF12569.3 KOO26411.1 - 2.7 6.6 10.8 3.8 6.1 7.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TPR_11 PF13414.1 KOO26412.1 - 2.7e-14 52.5 0.4 8e-14 51.0 0.3 1.9 1 0 0 1 1 1 1 TPR repeat TPR_2 PF07719.12 KOO26412.1 - 1.5e-13 49.4 1.2 4.3e-07 29.3 0.1 3.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO26412.1 - 2.1e-12 46.0 0.2 3.2e-05 23.3 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO26412.1 - 8.5e-10 38.0 0.4 0.0008 19.4 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO26412.1 - 1.3e-08 34.6 6.3 2.7e-05 24.4 0.2 3.6 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO26412.1 - 4e-08 33.7 3.5 0.00012 22.6 0.3 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO26412.1 - 6.5e-08 32.3 2.9 7.8e-08 32.1 0.6 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO26412.1 - 5.2e-07 28.9 0.5 0.0032 17.1 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO26412.1 - 5.2e-05 23.5 0.6 0.0096 16.2 0.1 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO26412.1 - 6.7e-05 22.6 12.6 0.00048 19.9 3.1 2.4 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_15 PF13429.1 KOO26412.1 - 0.00094 18.3 0.3 0.0089 15.1 0.1 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.1 KOO26412.1 - 0.012 15.5 4.0 1.2 9.1 0.2 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO26412.1 - 0.016 15.6 0.3 7.6 7.2 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOO26412.1 - 0.017 14.8 0.0 6.3 6.8 0.0 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat RPN7 PF10602.4 KOO26412.1 - 0.053 12.9 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 26S proteasome subunit RPN7 2OG-FeII_Oxy PF03171.15 KOO26412.1 - 0.13 12.6 0.0 0.59 10.4 0.0 2.1 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily Beach PF02138.13 KOO26413.1 - 2.4e-106 355.0 0.1 3.2e-106 354.6 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.1 KOO26413.1 - 1.1e-14 54.1 0.0 2.1e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.27 KOO26413.1 - 3.1e-13 49.0 2.4 2.2e-05 24.1 0.4 2.9 2 0 0 2 2 2 2 WD domain, G-beta repeat Laminin_G_3 PF13385.1 KOO26413.1 - 4.1e-09 36.8 0.0 9.7e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily CAP_N PF01213.14 KOO26413.1 - 0.63 9.2 1.0 1.2 8.3 0.7 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal zf-RING_2 PF13639.1 KOO26414.1 - 1.4e-12 47.2 14.4 2.1e-12 46.6 10.0 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KOO26414.1 - 7.1e-09 35.6 7.2 1.2e-08 34.9 5.0 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 KOO26414.1 - 0.00019 21.0 14.2 0.00028 20.4 9.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO26414.1 - 0.0012 18.4 11.1 0.0017 18.0 7.7 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO26414.1 - 0.0023 17.6 15.3 0.0033 17.1 10.6 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 KOO26414.1 - 0.004 17.1 14.9 0.0057 16.6 10.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 KOO26414.1 - 0.07 12.9 10.0 0.16 11.8 6.9 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.1 KOO26414.1 - 2.6 7.8 10.5 7.5 6.4 7.0 1.8 1 1 1 2 2 2 0 zf-RING of BARD1-type protein FANCL_C PF11793.3 KOO26414.1 - 6.5 6.7 15.5 1.9e+02 2.1 10.7 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain Ribosomal_S30 PF04758.9 KOO26415.1 - 0.046 13.4 0.0 0.052 13.3 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein S30 Spc7 PF08317.6 KOO26416.1 - 0.6 8.7 3.5 2.1 6.9 0.9 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Ank_2 PF12796.2 KOO26417.1 - 1.2e-08 35.1 1.1 3.6e-06 27.2 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO26417.1 - 0.00095 19.6 0.2 0.78 10.3 0.0 4.1 4 1 1 5 5 5 1 Ankyrin repeats (many copies) Ank PF00023.25 KOO26417.1 - 0.0025 17.5 0.1 0.12 12.2 0.0 3.5 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.1 KOO26417.1 - 0.0034 17.4 5.9 0.09 13.0 0.0 5.0 5 1 0 5 5 5 1 Ankyrin repeat Ank_5 PF13857.1 KOO26417.1 - 0.0048 17.0 0.1 0.3 11.4 0.0 3.9 5 0 0 5 5 5 1 Ankyrin repeats (many copies) Na_H_Exchanger PF00999.16 KOO26421.1 - 5.4e-51 173.2 36.5 2.4e-50 171.1 25.3 1.8 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family Sulfatase PF00884.18 KOO26421.1 - 7.1e-12 45.1 0.8 1.3e-11 44.2 0.5 1.3 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.1 KOO26421.1 - 0.026 14.8 0.0 0.045 14.0 0.0 1.4 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase SET PF00856.23 KOO26422.1 - 1.3e-09 38.6 0.0 4.8e-05 23.7 0.0 2.2 1 1 1 2 2 2 2 SET domain Oxysterol_BP PF01237.13 KOO26424.1 - 3e-37 127.9 0.0 8.5e-37 126.4 0.0 1.6 1 1 0 1 1 1 1 Oxysterol-binding protein BTB PF00651.26 KOO26425.1 - 0.02 14.9 0.0 0.081 12.9 0.0 1.9 1 1 1 2 2 2 0 BTB/POZ domain Filament PF00038.16 KOO26426.1 - 6.6 6.0 13.5 0.58 9.5 2.1 3.5 4 0 0 4 4 4 0 Intermediate filament protein ResIII PF04851.10 KOO26427.1 - 0.0002 21.2 0.4 0.047 13.5 0.0 3.6 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit PhoH PF02562.11 KOO26427.1 - 0.0021 17.3 0.0 0.0042 16.3 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein ELMO_CED12 PF04727.8 KOO26427.1 - 0.0051 16.3 0.1 0.02 14.4 0.0 2.0 2 0 0 2 2 2 1 ELMO/CED-12 family UvrD_C_2 PF13538.1 KOO26427.1 - 0.017 15.2 0.0 0.068 13.3 0.0 2.2 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_19 PF13245.1 KOO26427.1 - 0.019 14.7 0.0 0.019 14.7 0.0 2.8 2 0 0 2 2 2 0 Part of AAA domain AAA_22 PF13401.1 KOO26427.1 - 0.073 13.2 0.3 0.9 9.6 0.0 3.1 3 1 0 3 3 3 0 AAA domain Lactamase_B_2 PF12706.2 KOO26428.1 - 8.8e-28 97.1 0.1 1.4e-27 96.5 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain La PF05383.12 KOO26428.1 - 7.4e-18 64.1 0.0 1.3e-17 63.2 0.0 1.4 1 0 0 1 1 1 1 La domain Lactamase_B PF00753.22 KOO26428.1 - 9.7e-05 22.0 0.7 0.00056 19.6 0.5 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily GCK PF07802.6 KOO26429.1 - 2.4e-18 66.0 2.0 3.5e-18 65.4 1.4 1.3 1 0 0 1 1 1 1 GCK domain NOB1_Zn_bind PF08772.6 KOO26429.1 - 0.053 13.3 0.1 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like Cystatin PF00031.16 KOO26430.1 - 0.00018 21.5 0.1 0.00029 20.8 0.1 1.3 1 0 0 1 1 1 1 Cystatin domain DUF3359 PF11839.3 KOO26430.1 - 0.49 10.7 5.5 0.7 10.2 3.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3359) THOC7 PF05615.8 KOO26431.1 - 1.4e-17 64.2 10.3 1.5e-17 64.1 6.8 1.3 1 1 0 1 1 1 1 Tho complex subunit 7 DUF2342 PF10103.4 KOO26431.1 - 0.0038 16.2 2.0 0.0062 15.5 1.4 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2342) DUF2634 PF10934.3 KOO26431.1 - 0.062 13.0 0.1 0.2 11.4 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2634) GBP_C PF02841.9 KOO26431.1 - 0.066 12.3 11.3 0.23 10.5 7.8 1.7 1 1 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DUF2730 PF10805.3 KOO26431.1 - 0.077 12.7 3.9 0.37 10.5 2.7 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) HALZ PF02183.13 KOO26431.1 - 0.079 12.6 1.2 18 5.1 0.1 3.3 3 0 0 3 3 3 0 Homeobox associated leucine zipper AAA_23 PF13476.1 KOO26431.1 - 0.09 13.0 2.2 0.1 12.9 1.5 1.1 1 0 0 1 1 1 0 AAA domain Lzipper-MIP1 PF14389.1 KOO26431.1 - 0.13 12.3 10.5 0.98 9.5 2.8 2.9 2 1 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 AAA_13 PF13166.1 KOO26431.1 - 0.14 10.5 4.7 0.16 10.4 3.3 1.1 1 0 0 1 1 1 0 AAA domain 3H PF02829.9 KOO26431.1 - 0.22 11.5 2.1 0.28 11.2 0.8 1.7 1 1 0 2 2 2 0 3H domain Syntaxin PF00804.20 KOO26431.1 - 0.29 11.3 8.8 1.8 8.7 3.2 2.9 1 1 1 2 2 2 0 Syntaxin FliJ PF02050.11 KOO26431.1 - 0.45 10.5 12.1 1.4 9.0 2.8 3.1 1 1 2 3 3 3 0 Flagellar FliJ protein MbeB_N PF04837.7 KOO26431.1 - 0.54 10.3 6.5 10 6.3 0.1 3.6 4 0 0 4 4 4 0 MbeB-like, N-term conserved region DivIC PF04977.10 KOO26431.1 - 0.72 9.3 6.6 1.1 8.7 0.0 3.0 1 1 2 3 3 3 0 Septum formation initiator SlyX PF04102.7 KOO26431.1 - 1.4 9.3 10.2 2.4 8.6 2.6 3.4 2 1 2 4 4 4 0 SlyX Kinetocho_Slk19 PF12709.2 KOO26431.1 - 1.8 8.6 6.7 3 7.9 0.8 2.8 2 1 1 3 3 3 0 Central kinetochore-associated Fez1 PF06818.10 KOO26431.1 - 1.9 8.4 13.7 5.3 6.9 4.0 2.3 2 1 0 2 2 2 0 Fez1 CENP-F_leu_zip PF10473.4 KOO26431.1 - 3.8 7.3 12.6 5.9 6.7 0.7 2.6 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6 PF04111.7 KOO26431.1 - 5.7 5.8 11.6 9 5.2 4.6 2.0 1 1 1 2 2 2 0 Autophagy protein Apg6 DUF1192 PF06698.6 KOO26431.1 - 6.9 6.5 6.7 4 7.3 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) DUF848 PF05852.6 KOO26431.1 - 7.6 6.3 8.9 5.3 6.8 2.7 2.6 1 1 2 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) Ion_trans PF00520.26 KOO26433.1 - 1.4e-74 249.7 32.6 1.8e-40 138.3 10.2 2.7 3 0 0 3 3 3 2 Ion transport protein PKD_channel PF08016.7 KOO26433.1 - 7.5e-10 37.8 18.8 0.00051 18.5 0.2 5.1 5 1 0 5 5 5 4 Polycystin cation channel Methyltransf_23 PF13489.1 KOO26434.1 - 0.0061 16.2 0.0 0.0096 15.6 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain LRR_6 PF13516.1 KOO26435.1 - 4.7e-08 32.2 6.8 0.011 15.7 0.5 5.2 4 1 1 5 5 5 2 Leucine Rich repeat LRR_1 PF00560.28 KOO26435.1 - 0.0031 17.3 3.7 2.7 8.3 0.2 4.6 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_8 PF13855.1 KOO26435.1 - 0.0089 15.7 7.3 4.4 7.1 0.0 3.6 2 2 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.2 KOO26435.1 - 0.0096 15.5 9.2 0.053 13.1 0.5 3.6 2 2 2 4 4 4 2 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO26435.1 - 0.047 13.8 7.3 4.5 7.9 0.6 4.6 4 1 0 4 4 4 0 Leucine rich repeat Pyr_redox PF00070.22 KOO26436.1 - 1.2e-08 35.2 0.0 8e-07 29.3 0.0 3.0 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 KOO26436.1 - 8.1e-05 21.6 0.8 0.0038 16.1 0.2 2.6 1 1 1 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 KOO26436.1 - 0.00086 19.2 0.0 0.0014 18.5 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 KOO26436.1 - 0.0018 16.7 0.0 0.0028 16.1 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.14 KOO26436.1 - 0.0024 16.9 0.1 0.0059 15.6 0.1 1.6 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 KOO26436.1 - 0.0029 17.5 0.1 0.0081 16.1 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 KOO26436.1 - 0.0086 14.9 0.2 0.018 13.8 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.7 KOO26436.1 - 0.021 13.7 0.0 0.034 13.0 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_3 PF13738.1 KOO26436.1 - 0.075 13.0 0.0 0.18 11.8 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.1 KOO26436.1 - 0.084 13.1 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding Pkinase PF00069.20 KOO26437.1 - 9.8e-27 93.7 0.0 1.1e-26 93.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO26437.1 - 2.6e-20 72.5 0.0 3.2e-20 72.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO26437.1 - 2e-05 24.4 0.5 0.0003 20.6 0.2 2.0 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 KOO26437.1 - 0.0049 15.9 0.1 0.0068 15.4 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 KOO26437.1 - 0.04 13.2 0.0 0.041 13.2 0.0 1.3 1 1 0 1 1 1 0 RIO1 family Methyltransf_21 PF05050.7 KOO26440.1 - 0.033 14.1 0.0 0.042 13.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase FkbM domain SET PF00856.23 KOO26441.1 - 9.3e-11 42.2 0.0 1.3e-10 41.8 0.0 1.4 1 1 0 1 1 1 1 SET domain FKBP_C PF00254.23 KOO26442.1 - 9.1e-23 80.0 0.0 1.9e-22 79.0 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase PDZ_2 PF13180.1 KOO26442.1 - 9.4e-08 31.8 0.3 3.3e-07 30.0 0.2 1.8 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.19 KOO26442.1 - 5.2e-06 26.5 0.1 1e-05 25.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Thioredoxin PF00085.15 KOO26443.1 - 5.3e-07 29.2 0.0 8.1e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Calsequestrin PF01216.12 KOO26443.1 - 0.015 14.0 0.0 0.019 13.7 0.0 1.1 1 0 0 1 1 1 0 Calsequestrin HyaE PF07449.6 KOO26443.1 - 0.076 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Ion_trans PF00520.26 KOO26444.1 - 2.6e-76 255.3 16.1 6.2e-45 152.9 0.2 2.4 3 0 0 3 3 3 2 Ion transport protein 2OG-FeII_Oxy_2 PF13532.1 KOO26445.1 - 8.3e-14 51.8 0.0 2.9e-13 50.1 0.0 1.7 1 1 1 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO26445.1 - 1e-07 32.1 0.0 1.5e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Cep57_CLD_2 PF14197.1 KOO26446.1 - 9.9e-05 22.2 1.0 0.00024 20.9 0.7 1.6 1 0 0 1 1 1 1 Centrosome localisation domain of PPC89 Macoilin PF09726.4 KOO26446.1 - 0.0021 16.4 3.9 0.0024 16.2 2.7 1.0 1 0 0 1 1 1 1 Transmembrane protein CENP-F_leu_zip PF10473.4 KOO26446.1 - 0.0056 16.5 0.5 0.0099 15.7 0.4 1.4 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HrpB7 PF09486.5 KOO26446.1 - 0.0085 16.0 1.4 0.0085 16.0 1.0 2.0 2 1 0 2 2 2 1 Bacterial type III secretion protein (HrpB7) ERM PF00769.14 KOO26446.1 - 0.022 14.3 1.8 0.037 13.5 1.2 1.4 1 0 0 1 1 1 0 Ezrin/radixin/moesin family IF-2B PF01008.12 KOO26446.1 - 0.042 12.8 0.1 0.056 12.4 0.1 1.2 1 0 0 1 1 1 0 Initiation factor 2 subunit family TSC22 PF01166.13 KOO26446.1 - 0.045 13.7 0.2 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 TSC-22/dip/bun family RNase_E_G PF10150.4 KOO26446.1 - 0.065 12.4 0.3 0.11 11.7 0.2 1.3 1 0 0 1 1 1 0 Ribonuclease E/G family DUF2407_C PF13373.1 KOO26446.1 - 0.11 12.4 0.1 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 DUF2407 C-terminal domain EB1 PF03271.12 KOO26446.1 - 0.15 12.0 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 EB1-like C-terminal motif IncA PF04156.9 KOO26446.1 - 0.28 10.7 3.9 0.068 12.7 0.5 1.6 2 0 0 2 2 2 0 IncA protein NADH-G_4Fe-4S_3 PF10588.4 KOO26446.1 - 0.83 8.9 3.2 1 8.6 0.1 2.2 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Filamin PF00630.14 KOO26447.1 - 7e-21 74.6 0.0 3e-17 63.0 0.0 2.5 2 1 0 2 2 2 2 Filamin/ABP280 repeat QPP PF07640.6 KOO26447.1 - 0.0049 16.5 0.0 0.025 14.2 0.0 2.1 2 0 0 2 2 2 1 QPP Neurexophilin PF06312.7 KOO26447.1 - 0.098 11.8 0.1 0.29 10.3 0.0 1.5 1 1 0 1 1 1 0 Neurexophilin His_Phos_1 PF00300.17 KOO26448.1 - 2.6e-10 40.6 0.0 6.3e-10 39.3 0.0 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) YozD PF14162.1 KOO26448.1 - 0.088 12.9 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 YozD-like protein Peptidase_M14 PF00246.19 KOO26449.1 - 1.9e-26 93.2 0.0 3.7e-26 92.3 0.0 1.4 1 0 0 1 1 1 1 Zinc carboxypeptidase EF-hand_6 PF13405.1 KOO26449.1 - 3.4e-11 42.0 1.3 4.5e-06 26.1 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO26449.1 - 2.2e-10 39.0 4.0 4.5e-06 25.5 0.3 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO26449.1 - 7.6e-09 35.5 2.2 1.5e-08 34.6 1.5 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO26449.1 - 6.7e-08 31.5 7.4 4.3e-05 22.6 0.8 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO26449.1 - 7.1e-06 25.5 2.9 0.00033 20.1 0.2 2.2 1 1 1 2 2 2 2 EF-hand domain pair Filamin PF00630.14 KOO26450.1 - 1.4e-23 83.3 0.0 2.4e-05 24.8 0.0 5.1 4 1 0 4 4 4 4 Filamin/ABP280 repeat Ion_trans PF00520.26 KOO26451.1 - 1.1e-21 76.9 4.5 1.6e-21 76.5 3.2 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO26451.1 - 1.3e-08 34.3 3.8 1.3e-08 34.3 2.6 2.0 2 0 0 2 2 2 1 Ion channel Homeobox PF00046.24 KOO26452.1 - 5e-17 61.2 0.4 8.7e-17 60.4 0.3 1.3 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 KOO26452.1 - 0.0017 18.0 0.3 0.0038 16.8 0.2 1.6 1 0 0 1 1 1 1 Homeobox KN domain Rhomboid PF01694.17 KOO26454.1 - 2.9e-34 118.2 9.6 2.9e-34 118.2 6.7 1.8 2 0 0 2 2 2 1 Rhomboid family IQ PF00612.22 KOO26454.1 - 0.0013 18.2 0.2 0.0013 18.2 0.1 3.1 3 0 0 3 3 3 1 IQ calmodulin-binding motif IQ PF00612.22 KOO26456.1 - 0.067 12.8 0.1 0.2 11.4 0.1 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif His_kinase PF06580.8 KOO26458.1 - 0.025 14.5 0.5 0.058 13.3 0.4 1.7 1 0 0 1 1 1 0 Histidine kinase Fib_alpha PF08702.5 KOO26458.1 - 0.072 13.2 1.4 0.13 12.3 1.0 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF4200 PF13863.1 KOO26458.1 - 0.19 11.6 8.9 0.21 11.5 5.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) V_ATPase_I PF01496.14 KOO26458.1 - 0.22 9.3 1.3 0.27 9.0 0.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF342 PF03961.8 KOO26458.1 - 0.81 8.0 4.5 0.7 8.2 1.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF342) SHIPPO-rpt PF07004.7 KOO26459.1 - 1.2e-11 44.8 23.3 0.058 14.3 0.1 6.9 6 1 0 6 6 6 6 Sperm-tail PG-rich repeat ECR1_N PF14382.1 KOO26459.1 - 1e-05 24.7 2.3 0.081 12.2 0.0 4.2 4 0 0 4 4 4 2 Exosome complex exonuclease RRP4 N-terminal region C2 PF00168.25 KOO26461.1 - 3.4e-15 55.6 0.1 6.2e-15 54.8 0.1 1.5 1 0 0 1 1 1 1 C2 domain Peptidase_M10 PF00413.19 KOO26461.1 - 0.00062 19.5 0.0 0.47 10.1 0.0 3.3 3 0 0 3 3 3 1 Matrixin Ceramidase PF05875.7 KOO26461.1 - 0.057 12.5 1.7 0.068 12.2 0.1 1.8 2 0 0 2 2 2 0 Ceramidase EF-hand_5 PF13202.1 KOO26461.1 - 0.084 12.2 0.1 0.2 11.0 0.1 1.6 1 0 0 1 1 1 0 EF hand Peptidase_M66 PF10462.4 KOO26461.1 - 0.15 10.8 0.1 0.26 10.1 0.1 1.3 1 0 0 1 1 1 0 Peptidase M66 Metallopep PF12044.3 KOO26461.1 - 0.22 9.9 0.6 0.35 9.2 0.4 1.2 1 0 0 1 1 1 0 Putative peptidase family Ank_2 PF12796.2 KOO26462.1 - 3e-28 97.9 12.6 4.2e-10 39.8 1.8 4.4 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 KOO26462.1 - 3.1e-23 80.3 20.6 6.2e-06 25.7 0.1 7.7 7 0 0 7 7 7 7 Ankyrin repeat Ank_4 PF13637.1 KOO26462.1 - 1.3e-19 70.1 13.4 0.0001 22.7 0.0 6.2 3 1 3 6 6 6 5 Ankyrin repeats (many copies) FYVE PF01363.16 KOO26462.1 - 1.7e-18 66.2 6.8 3.2e-18 65.3 4.7 1.4 1 0 0 1 1 1 1 FYVE zinc finger Ank_5 PF13857.1 KOO26462.1 - 1.5e-17 63.1 16.6 4.3e-10 39.5 0.3 5.9 6 1 0 6 6 6 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO26462.1 - 2.6e-16 58.0 13.1 0.0007 19.6 0.1 8.1 8 0 0 8 8 8 3 Ankyrin repeat FYVE_2 PF02318.11 KOO26462.1 - 0.0058 16.5 4.7 0.011 15.6 3.2 1.3 1 0 0 1 1 1 1 FYVE-type zinc finger BACK PF07707.10 KOO26462.1 - 0.024 14.4 0.1 0.23 11.3 0.0 2.2 2 0 0 2 2 2 0 BTB And C-terminal Kelch zf-C2HC_2 PF13913.1 KOO26463.1 - 1.6e-09 37.1 2.1 2.5e-09 36.5 1.4 1.3 1 0 0 1 1 1 1 zinc-finger of a C2HC-type DUF1128 PF06569.6 KOO26463.1 - 0.15 11.8 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1128) GST_C_2 PF13410.1 KOO26464.1 - 2.1e-08 33.9 0.2 2.1e-08 33.9 0.2 2.3 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 KOO26464.1 - 0.00053 20.4 0.1 0.0016 18.9 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 KOO26464.1 - 0.064 13.4 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Glyco_transf_20 PF00982.16 KOO26465.1 - 2.3e-113 379.2 0.0 1.5e-67 228.1 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 KOO26465.1 - 5.9e-49 166.1 0.0 8.5e-49 165.5 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase CBM_20 PF00686.14 KOO26465.1 - 8.7e-13 47.6 0.0 1.9e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 Starch binding domain Hydrolase_3 PF08282.7 KOO26465.1 - 0.00061 19.4 0.0 0.0029 17.2 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Glycos_transf_1 PF00534.15 KOO26465.1 - 0.12 11.7 0.0 0.26 10.7 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 SpecificRecomb PF10136.4 KOO26466.1 - 0.059 11.4 16.7 0.088 10.8 11.2 1.5 1 1 0 1 1 1 0 Site-specific recombinase DUF724 PF05266.9 KOO26466.1 - 0.77 9.3 11.3 0.083 12.5 4.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) ENT PF03735.9 KOO26469.1 - 0.42 10.3 5.5 0.1 12.2 0.5 2.5 3 0 0 3 3 3 0 ENT domain OTU PF02338.14 KOO26470.1 - 1.9e-08 34.9 0.7 5.7e-06 26.9 0.0 3.0 3 0 0 3 3 3 2 OTU-like cysteine protease CBFB_NFYA PF02045.10 KOO26470.1 - 6.3 7.4 6.9 1.5 9.4 0.1 2.6 2 0 0 2 2 2 0 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Methyltransf_21 PF05050.7 KOO26471.1 - 2.4e-09 37.3 0.0 3.3e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_18 PF12847.2 KOO26471.1 - 0.14 12.7 0.0 0.33 11.5 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain PNP_UDP_1 PF01048.15 KOO26472.1 - 1.2e-38 132.3 0.4 2.7e-38 131.2 0.3 1.5 1 0 0 1 1 1 1 Phosphorylase superfamily Bravo_FIGEY PF13882.1 KOO26472.1 - 3.3 8.6 7.2 9.4 7.2 3.0 2.4 2 0 0 2 2 2 0 Bravo-like intracellular region Chloroa_b-bind PF00504.16 KOO26473.1 - 9.3e-30 103.9 0.1 1.2e-29 103.5 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein EF-hand_7 PF13499.1 KOO26474.1 - 1.4e-13 50.7 0.9 1.1e-10 41.5 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO26474.1 - 5.6e-09 35.4 1.4 1.6e-05 24.4 0.0 3.3 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO26474.1 - 7.1e-09 34.3 0.1 0.005 16.0 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 KOO26474.1 - 3e-06 26.6 1.7 0.0032 17.2 0.1 3.7 3 1 1 4 4 4 2 EF-hand domain EF-hand_5 PF13202.1 KOO26474.1 - 1.3e-05 24.3 0.7 0.3 10.5 0.1 4.3 4 0 0 4 4 4 1 EF hand Collagen PF01391.13 KOO26474.1 - 0.018 14.5 7.0 0.035 13.6 4.8 1.4 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) PTS_2-RNA PF01885.11 KOO26474.1 - 0.072 12.3 0.0 0.19 10.9 0.0 1.4 1 1 0 1 1 1 0 RNA 2'-phosphotransferase, Tpt1 / KptA family Glu_synthase PF01645.12 KOO26475.1 - 1.7e-70 237.7 0.8 2.6e-70 237.1 0.6 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase TPR_12 PF13424.1 KOO26475.1 - 3e-20 71.9 25.4 1.4e-07 31.3 1.1 5.6 4 1 1 6 6 6 4 Tetratricopeptide repeat CHAT PF12770.2 KOO26475.1 - 4.2e-20 72.0 0.2 1.3e-19 70.4 0.1 1.8 1 0 0 1 1 1 1 CHAT domain TPR_11 PF13414.1 KOO26475.1 - 7.7e-09 35.0 14.8 0.0009 18.8 0.5 5.1 3 1 2 5 5 5 2 TPR repeat TPR_2 PF07719.12 KOO26475.1 - 1.9e-08 33.6 18.8 2.7 8.1 0.0 8.7 9 1 0 9 9 9 4 Tetratricopeptide repeat TPR_8 PF13181.1 KOO26475.1 - 1.9e-08 33.4 0.9 5.3 7.0 0.1 6.8 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO26475.1 - 1.7e-06 27.4 5.1 0.67 9.6 0.0 7.0 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO26475.1 - 0.00068 20.2 35.4 0.27 11.9 3.3 7.6 5 2 2 7 7 7 4 Tetratricopeptide repeat RPN7 PF10602.4 KOO26475.1 - 0.0019 17.5 0.3 0.086 12.2 0.0 2.7 2 1 1 3 3 3 1 26S proteasome subunit RPN7 Apc3 PF12895.2 KOO26475.1 - 0.13 12.3 4.7 27 4.9 0.1 4.0 2 2 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 KOO26475.1 - 0.3 11.8 30.5 2.5 8.9 0.6 8.3 6 3 3 9 9 8 0 Tetratricopeptide repeat TPR_10 PF13374.1 KOO26475.1 - 0.46 10.4 26.7 0.86 9.6 0.3 8.0 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO26475.1 - 1.2 9.0 21.8 15 5.6 0.0 7.4 8 1 0 8 8 8 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO26475.1 - 2.4 8.0 15.6 2.4 8.0 1.0 4.7 3 1 1 4 4 4 0 Tetratricopeptide repeat LRR_6 PF13516.1 KOO26476.1 - 9.4e-41 133.2 0.6 0.0061 16.5 0.0 11.6 11 0 0 11 11 11 9 Leucine Rich repeat NACHT PF05729.7 KOO26476.1 - 2e-05 24.3 0.0 4.8e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 NACHT domain EcKinase PF02958.15 KOO26476.1 - 8.4e-05 21.8 0.0 0.00022 20.4 0.0 1.6 2 0 0 2 2 2 1 Ecdysteroid kinase LRR_4 PF12799.2 KOO26476.1 - 0.0077 15.8 0.1 6.1 6.5 0.0 4.4 4 1 0 5 5 5 1 Leucine Rich repeats (2 copies) RRM_1 PF00076.17 KOO26476.1 - 0.016 14.8 0.0 0.043 13.4 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RIO1 PF01163.17 KOO26476.1 - 0.02 14.2 0.0 0.04 13.2 0.0 1.4 1 0 0 1 1 1 0 RIO1 family RRM_6 PF14259.1 KOO26476.1 - 0.028 14.3 0.1 0.085 12.8 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO26476.1 - 0.078 12.8 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_14 PF13173.1 KOO26476.1 - 0.58 10.0 0.0 1.2 9.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.20 KOO26476.1 - 0.74 8.9 0.0 1.4 8.0 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain Parvo_NS1 PF01057.12 KOO26476.1 - 0.96 8.2 0.0 2.1 7.1 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF2202 PF09968.4 KOO26476.1 - 1 9.0 3.6 24 4.5 0.1 3.6 3 1 0 3 3 3 0 Uncharacterized protein domain (DUF2202) PPV_E1_C PF00519.12 KOO26476.1 - 1.6 7.2 0.1 5.4 5.5 0.1 1.8 2 1 0 2 2 2 0 Papillomavirus helicase WD40 PF00400.27 KOO26477.1 - 1.7e-39 132.2 13.6 6.1e-06 25.9 0.1 15.4 15 0 0 15 15 15 9 WD domain, G-beta repeat DUF667 PF05018.8 KOO26477.1 - 1.4e-05 24.3 0.0 2.2e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF667) Cytochrom_D1 PF02239.11 KOO26477.1 - 0.0018 16.6 0.0 0.15 10.3 0.0 3.5 4 1 1 5 5 5 1 Cytochrome D1 heme domain Nucleoporin_N PF08801.6 KOO26477.1 - 0.12 11.0 0.0 0.24 10.1 0.0 1.4 1 0 0 1 1 1 0 Nup133 N terminal like Nbas_N PF15492.1 KOO26477.1 - 0.15 11.1 0.1 4 6.4 0.0 3.1 3 0 0 3 3 3 0 Neuroblastoma-amplified sequence, N terminal DUF3312 PF11768.3 KOO26477.1 - 0.66 8.1 0.0 1.1 7.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3312) RAB3GAP2_N PF14655.1 KOO26477.1 - 0.86 8.5 0.0 21 3.9 0.0 2.5 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF4586 PF15239.1 KOO26478.1 - 1.9e-31 109.7 11.4 7.1e-31 107.8 7.9 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4586) Sugar_tr PF00083.19 KOO26479.1 - 2.8e-40 138.2 18.7 1.7e-36 125.7 9.4 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 KOO26479.1 - 1.6e-14 53.3 21.1 1.6e-14 53.3 14.6 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.1 KOO26479.1 - 0.00037 19.0 1.1 0.00037 19.0 0.8 2.2 1 1 0 2 2 2 1 MFS/sugar transport protein DUF791 PF05631.9 KOO26479.1 - 0.0005 18.8 0.8 0.00064 18.5 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF791) TraD PF06412.6 KOO26479.1 - 1.4 8.6 4.4 0.52 9.9 0.8 2.0 2 0 0 2 2 2 0 Conjugal transfer protein TraD Glyco_transf_8 PF01501.15 KOO26480.1 - 0.15 11.3 2.8 2.4 7.4 0.7 2.8 3 0 0 3 3 3 0 Glycosyl transferase family 8 Glyco_transf_54 PF04666.8 KOO26481.1 - 0.05 12.3 0.0 0.065 11.9 0.0 1.1 1 0 0 1 1 1 0 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Glyco_transf_25 PF01755.12 KOO26481.1 - 0.058 13.0 0.0 0.081 12.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 25 (LPS biosynthesis protein) Myosin_head PF00063.16 KOO26482.1 - 9.3e-179 595.7 0.0 1.4e-178 595.1 0.0 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) PH PF00169.24 KOO26482.1 - 0.047 13.8 0.0 0.12 12.5 0.0 1.8 1 0 0 1 1 1 0 PH domain IQ PF00612.22 KOO26482.1 - 4.1 7.3 9.5 14 5.6 0.5 3.1 2 0 0 2 2 2 0 IQ calmodulin-binding motif CBF PF03914.12 KOO26483.1 - 7.8e-20 70.9 0.2 2.6e-09 36.7 0.4 2.3 2 0 0 2 2 2 2 CBF/Mak21 family DDE_Tnp_1_6 PF13751.1 KOO26484.1 - 3.4 7.6 11.6 0.16 12.0 0.5 3.0 2 1 1 3 3 3 0 Transposase DDE domain Pyr_redox_2 PF07992.9 KOO26485.1 - 3.5e-05 23.7 0.0 0.00012 22.0 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOO26485.1 - 5.1e-05 23.5 0.0 0.004 17.5 0.0 2.8 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 KOO26485.1 - 0.00043 19.3 0.3 0.0012 17.8 0.2 1.7 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_3 PF01494.14 KOO26485.1 - 0.0036 16.4 0.1 0.0036 16.4 0.1 3.1 4 0 0 4 4 3 1 FAD binding domain FAD_binding_2 PF00890.19 KOO26485.1 - 0.0047 15.8 0.4 0.0047 15.8 0.3 2.5 2 1 1 3 3 3 1 FAD binding domain DAO PF01266.19 KOO26485.1 - 0.0088 14.9 0.7 0.0088 14.9 0.5 3.4 2 1 1 3 3 3 1 FAD dependent oxidoreductase HI0933_like PF03486.9 KOO26485.1 - 0.014 13.9 0.1 0.014 13.9 0.0 2.4 3 0 0 3 3 3 0 HI0933-like protein Pyr_redox_3 PF13738.1 KOO26485.1 - 0.061 13.3 0.0 0.2 11.7 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAM60A PF15396.1 KOO26485.1 - 0.11 12.2 0.7 0.21 11.3 0.5 1.4 1 0 0 1 1 1 0 Protein Family FAM60A Thi4 PF01946.12 KOO26485.1 - 0.14 11.1 0.1 0.41 9.7 0.0 1.8 2 0 0 2 2 2 0 Thi4 family NAD_binding_7 PF13241.1 KOO26485.1 - 0.19 12.0 2.8 0.33 11.2 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding UQ_con PF00179.21 KOO26486.1 - 8.6e-45 151.6 0.0 1e-44 151.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA PF00627.26 KOO26486.1 - 1.7e-10 40.4 1.1 1.6e-09 37.3 0.1 2.3 2 0 0 2 2 2 1 UBA/TS-N domain Prok-E2_B PF14461.1 KOO26486.1 - 8e-06 25.6 0.0 2.8e-05 23.8 0.0 1.7 1 1 1 2 2 2 1 Prokaryotic E2 family B UBA_3 PF09288.5 KOO26486.1 - 0.00065 19.2 0.0 0.0018 17.8 0.0 1.6 2 0 0 2 2 2 1 Fungal ubiquitin-associated domain RWD PF05773.17 KOO26486.1 - 0.018 14.9 0.1 0.024 14.5 0.0 1.4 1 1 0 1 1 1 0 RWD domain CUE PF02845.11 KOO26486.1 - 0.37 10.3 1.4 0.69 9.4 0.0 2.0 2 0 0 2 2 2 0 CUE domain AIG1 PF04548.11 KOO26487.1 - 7.2e-11 41.6 0.0 8.9e-11 41.2 0.0 1.1 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.18 KOO26487.1 - 0.012 15.5 0.0 0.016 15.1 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.1 KOO26487.1 - 0.036 14.0 0.1 0.051 13.5 0.1 1.2 1 0 0 1 1 1 0 AAA ATPase domain PGK PF00162.14 KOO26488.1 - 4e-164 545.7 0.1 4.9e-164 545.4 0.1 1.1 1 0 0 1 1 1 1 Phosphoglycerate kinase Cupin_3 PF05899.7 KOO26489.1 - 1.4e-07 30.7 0.2 8.4e-07 28.2 0.2 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF861) TraB PF01963.12 KOO26490.1 - 8.8e-14 51.5 0.5 1.2e-13 51.1 0.3 1.1 1 0 0 1 1 1 1 TraB family Laminin_II PF06009.7 KOO26492.1 - 0.00023 20.9 1.9 0.00045 19.9 1.3 1.5 1 0 0 1 1 1 1 Laminin Domain II Seryl_tRNA_N PF02403.17 KOO26492.1 - 0.011 15.7 2.9 0.011 15.7 2.0 1.9 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TBPIP PF07106.8 KOO26492.1 - 0.026 14.0 0.6 0.026 14.0 0.4 1.6 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Extensin_2 PF04554.8 KOO26492.1 - 0.028 14.2 35.0 0.034 14.0 23.7 1.6 1 1 0 1 1 1 0 Extensin-like region DUF4407 PF14362.1 KOO26492.1 - 0.034 13.1 13.1 0.045 12.7 9.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cor1 PF04803.7 KOO26492.1 - 0.041 13.6 0.1 0.18 11.5 0.1 1.9 1 1 0 1 1 1 0 Cor1/Xlr/Xmr conserved region Spc7 PF08317.6 KOO26492.1 - 0.051 12.2 2.5 0.1 11.2 1.2 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein Microtub_assoc PF07989.6 KOO26492.1 - 0.083 12.7 0.9 0.29 10.9 0.1 2.1 1 1 1 2 2 2 0 Microtubule associated CENP-F_leu_zip PF10473.4 KOO26492.1 - 0.19 11.6 10.2 0.14 12.0 3.1 2.5 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Uds1 PF15456.1 KOO26492.1 - 0.41 10.6 16.2 1.9 8.4 1.3 2.5 1 1 1 2 2 2 0 Up-regulated During Septation Tropomyosin PF00261.15 KOO26492.1 - 0.7 8.9 19.8 1.1 8.3 4.0 2.9 2 1 1 3 3 3 0 Tropomyosin GAS PF13851.1 KOO26492.1 - 0.84 8.7 8.6 0.096 11.8 2.3 1.9 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding THOC7 PF05615.8 KOO26492.1 - 0.92 9.7 8.7 0.17 12.1 1.0 2.4 1 1 1 2 2 2 0 Tho complex subunit 7 DUF3584 PF12128.3 KOO26492.1 - 1.1 6.5 15.5 1.5 6.0 10.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Tropomyosin_1 PF12718.2 KOO26492.1 - 1.7 8.4 13.3 0.61 9.9 5.6 2.4 2 1 1 3 3 3 0 Tropomyosin like Mnd1 PF03962.10 KOO26492.1 - 1.8 8.1 10.6 0.12 12.0 3.0 1.8 2 0 0 2 2 2 0 Mnd1 family IncA PF04156.9 KOO26492.1 - 2.4 7.7 14.7 7 6.2 9.9 1.9 1 1 0 1 1 1 0 IncA protein TMF_TATA_bd PF12325.3 KOO26492.1 - 3 7.6 8.8 0.36 10.5 3.1 1.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF4200 PF13863.1 KOO26492.1 - 4.2 7.3 14.4 0.82 9.6 4.6 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) APG6 PF04111.7 KOO26492.1 - 7 5.5 7.8 3.8 6.4 3.8 1.6 1 1 1 2 2 2 0 Autophagy protein Apg6 EamA PF00892.15 KOO26493.1 - 4.7e-10 39.5 26.4 1.5e-05 24.9 6.9 2.6 1 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.6 KOO26493.1 - 3.8e-08 32.5 21.8 5.7e-08 32.0 15.1 1.2 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 KOO26493.1 - 3.9e-06 26.5 12.1 3.9e-06 26.5 8.4 2.8 2 1 0 2 2 2 1 Triose-phosphate Transporter family Form-deh_trans PF09163.6 KOO26493.1 - 7.6 6.1 10.5 0.29 10.6 1.0 3.2 3 0 0 3 3 3 0 Formate dehydrogenase N, transmembrane ATP_bind_1 PF03029.12 KOO26494.1 - 1.1e-78 264.1 0.0 1.4e-78 263.7 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.22 KOO26494.1 - 2e-07 30.6 0.0 1.4e-06 27.8 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_17 PF13207.1 KOO26494.1 - 5.7e-07 30.3 0.1 6.1e-06 27.0 0.0 2.5 2 1 0 2 2 2 1 AAA domain PduV-EutP PF10662.4 KOO26494.1 - 1e-05 25.0 0.1 3e-05 23.5 0.0 1.8 2 0 0 2 2 1 1 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.13 KOO26494.1 - 1.5e-05 24.3 0.0 0.00067 18.9 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B SRPRB PF09439.5 KOO26494.1 - 3.4e-05 23.1 0.0 0.021 14.0 0.0 2.2 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 KOO26494.1 - 3.5e-05 23.7 0.0 7.7e-05 22.6 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_18 PF13238.1 KOO26494.1 - 0.00011 22.4 0.0 0.00094 19.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KOO26494.1 - 0.00015 21.8 0.0 0.00036 20.5 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 KOO26494.1 - 0.00017 21.7 0.0 0.00036 20.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain Arf PF00025.16 KOO26494.1 - 0.00027 20.2 0.0 0.043 13.0 0.0 2.4 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_33 PF13671.1 KOO26494.1 - 0.00043 20.1 0.0 0.00096 19.0 0.0 1.7 2 0 0 2 2 1 1 AAA domain NACHT PF05729.7 KOO26494.1 - 0.00057 19.5 0.0 0.0015 18.2 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_30 PF13604.1 KOO26494.1 - 0.0013 18.3 0.1 0.0039 16.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.17 KOO26494.1 - 0.0013 17.6 0.0 0.0031 16.4 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain SRP54 PF00448.17 KOO26494.1 - 0.0019 17.6 0.0 0.0051 16.2 0.0 1.7 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain cobW PF02492.14 KOO26494.1 - 0.0031 16.9 0.0 0.04 13.3 0.0 2.2 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.9 KOO26494.1 - 0.0032 17.1 0.0 0.007 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 KOO26494.1 - 0.0035 16.4 0.0 0.0083 15.2 0.0 1.6 2 0 0 2 2 1 1 Zeta toxin AAA_14 PF13173.1 KOO26494.1 - 0.0037 17.1 0.0 0.0081 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain MobB PF03205.9 KOO26494.1 - 0.0062 16.2 0.0 0.013 15.1 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_28 PF13521.1 KOO26494.1 - 0.0068 16.3 0.1 0.037 14.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 KOO26494.1 - 0.0098 15.3 0.0 0.014 14.8 0.0 1.5 1 1 0 1 1 1 1 AAA-like domain Miro PF08477.8 KOO26494.1 - 0.021 15.3 0.0 1.1 9.8 0.0 2.4 2 0 0 2 2 2 0 Miro-like protein KTI12 PF08433.5 KOO26494.1 - 0.035 13.3 0.0 0.056 12.6 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 ArgK PF03308.11 KOO26494.1 - 0.037 12.7 0.0 0.56 8.9 0.0 2.2 2 0 0 2 2 2 0 ArgK protein Ras PF00071.17 KOO26494.1 - 0.042 13.2 0.0 7.4 5.9 0.0 2.2 2 0 0 2 2 2 0 Ras family APS_kinase PF01583.15 KOO26494.1 - 0.047 13.3 0.0 0.095 12.3 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_19 PF13245.1 KOO26494.1 - 0.053 13.2 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain AAA_29 PF13555.1 KOO26494.1 - 0.087 12.3 0.0 0.22 11.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Thymidylate_kin PF02223.12 KOO26494.1 - 0.092 12.1 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 Thymidylate kinase T2SE PF00437.15 KOO26494.1 - 0.1 11.4 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein NTPase_1 PF03266.10 KOO26494.1 - 0.13 12.0 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 NTPase Mg_chelatase PF01078.16 KOO26494.1 - 0.13 11.3 0.0 0.49 9.5 0.0 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Viral_helicase1 PF01443.13 KOO26494.1 - 0.14 11.6 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.22 KOO26494.1 - 0.15 12.3 0.0 0.34 11.2 0.0 1.5 1 0 0 1 1 1 0 ABC transporter DUF258 PF03193.11 KOO26494.1 - 0.17 11.0 0.0 0.61 9.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Lectin_N PF03954.9 KOO26496.1 - 0.0082 15.5 0.5 0.11 11.8 0.3 2.0 1 1 0 1 1 1 1 Hepatic lectin, N-terminal domain IncA PF04156.9 KOO26496.1 - 0.043 13.4 0.1 0.078 12.5 0.1 1.5 1 1 0 1 1 1 0 IncA protein VWA PF00092.23 KOO26497.1 - 2.2e-29 102.4 0.0 3.2e-29 101.9 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.1 KOO26497.1 - 1.1e-15 58.2 0.1 3.1e-15 56.7 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain DUF493 PF04359.9 KOO26497.1 - 6.7e-08 32.7 0.0 1.8e-07 31.3 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF493) VWA_CoxE PF05762.9 KOO26497.1 - 0.015 14.4 0.0 0.11 11.5 0.0 2.0 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein PSI PF01437.20 KOO26497.1 - 0.037 14.1 9.6 0.15 12.2 6.6 2.2 1 0 0 1 1 1 0 Plexin repeat DUF3584 PF12128.3 KOO26498.1 - 0.002 15.5 8.4 0.002 15.5 5.9 2.1 1 1 0 2 2 2 2 Protein of unknown function (DUF3584) IFT20 PF14931.1 KOO26498.1 - 0.0095 15.8 4.1 0.0095 15.8 2.9 3.2 1 1 2 3 3 3 1 Intraflagellar transport complex B, subunit 20 Filament PF00038.16 KOO26498.1 - 0.013 14.9 37.4 0.089 12.2 8.7 3.2 1 1 2 3 3 3 0 Intermediate filament protein DUF972 PF06156.8 KOO26498.1 - 0.037 14.3 2.0 0.037 14.3 1.4 4.0 1 1 1 3 3 3 0 Protein of unknown function (DUF972) Mating_N PF12731.2 KOO26498.1 - 0.1 12.5 8.1 0.22 11.4 0.3 3.7 3 2 1 4 4 4 0 Mating-type protein beta 1 SWI-SNF_Ssr4 PF08549.5 KOO26498.1 - 0.45 8.7 6.6 0.69 8.1 4.6 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) TMP_2 PF06791.8 KOO26498.1 - 0.73 9.4 13.2 0.079 12.5 2.6 3.2 2 2 2 4 4 4 0 Prophage tail length tape measure protein Baculo_PEP_C PF04513.7 KOO26498.1 - 0.83 9.4 20.2 1.5 8.6 2.4 4.4 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus ERM PF00769.14 KOO26498.1 - 1.1 8.6 38.3 1.3 8.4 11.2 2.4 1 1 1 2 2 2 0 Ezrin/radixin/moesin family FliD_C PF07195.7 KOO26498.1 - 6.6 5.9 11.5 3 7.0 2.2 2.8 2 2 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Spc7 PF08317.6 KOO26498.1 - 9.5 4.7 30.2 3 6.4 5.1 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein PhzC-PhzF PF02567.11 KOO26499.1 - 2.2e-43 148.5 0.0 1.3e-42 145.9 0.0 1.9 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein MGDG_synth PF06925.6 KOO26501.1 - 3.4e-28 98.6 0.0 4.5e-28 98.2 0.0 1.2 1 0 0 1 1 1 1 Monogalactosyldiacylglycerol (MGDG) synthase Glyco_tran_28_C PF04101.11 KOO26501.1 - 2e-13 50.3 0.0 4.8e-13 49.0 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_4 PF13692.1 KOO26501.1 - 1.4e-06 28.4 0.0 9.1e-06 25.8 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_3 PF13528.1 KOO26501.1 - 7.4e-06 25.3 0.0 2.1e-05 23.8 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferase family 1 Glycos_transf_1 PF00534.15 KOO26501.1 - 0.00045 19.6 0.0 0.00065 19.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 KOO26501.1 - 0.069 13.4 0.0 0.32 11.3 0.0 2.0 1 1 0 1 1 1 0 Glycosyl transferases group 1 TPR_12 PF13424.1 KOO26502.1 - 2.9e-08 33.5 9.1 0.00075 19.3 1.2 3.1 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO26502.1 - 1.3e-05 24.7 6.3 0.69 9.9 0.0 5.0 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO26502.1 - 0.0038 17.8 12.9 0.031 14.9 0.0 4.0 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO26502.1 - 0.0052 16.4 0.0 0.77 9.6 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 KOO26502.1 - 0.022 15.1 5.5 33 5.2 0.2 4.4 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 KOO26502.1 - 0.052 13.2 5.1 3.2 7.4 0.5 3.3 2 1 1 3 3 3 0 TPR repeat AstE_AspA PF04952.9 KOO26502.1 - 0.054 12.3 0.3 0.073 11.9 0.2 1.2 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family TPR_14 PF13428.1 KOO26502.1 - 0.14 12.8 8.8 3 8.7 0.2 4.5 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOO26502.1 - 0.15 11.7 5.5 8.3 6.2 0.2 4.3 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.1 KOO26502.1 - 0.22 11.8 10.5 16 5.9 0.1 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO26502.1 - 0.26 11.1 9.6 16 5.5 0.0 4.8 4 1 0 4 4 4 0 Tetratricopeptide repeat zf-HC2 PF13490.1 KOO26503.1 - 0.042 13.7 0.7 6.5 6.7 0.2 3.3 3 0 0 3 3 3 0 Putative zinc-finger Amnionless PF14828.1 KOO26503.1 - 0.13 10.7 0.2 0.16 10.4 0.1 1.1 1 0 0 1 1 1 0 Amnionless SHOCT PF09851.4 KOO26503.1 - 1.5 8.3 7.1 0.88 9.1 0.7 2.6 2 0 0 2 2 2 0 Short C-terminal domain SPX PF03105.14 KOO26504.1 - 0.82 9.3 13.0 5.5 6.6 0.0 2.3 2 0 0 2 2 2 0 SPX domain Sugar_tr PF00083.19 KOO26505.1 - 2.8e-40 138.2 18.7 1.7e-36 125.7 9.4 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 KOO26505.1 - 1.6e-14 53.3 21.1 1.6e-14 53.3 14.6 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.1 KOO26505.1 - 0.00037 19.0 1.1 0.00037 19.0 0.8 2.2 1 1 0 2 2 2 1 MFS/sugar transport protein DUF791 PF05631.9 KOO26505.1 - 0.0005 18.8 0.8 0.00064 18.5 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF791) TraD PF06412.6 KOO26505.1 - 1.4 8.6 4.4 0.52 9.9 0.8 2.0 2 0 0 2 2 2 0 Conjugal transfer protein TraD EF-hand_5 PF13202.1 KOO26506.1 - 2.6e-18 64.4 0.0 0.00015 20.9 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 KOO26506.1 - 3.3e-16 57.6 0.0 0.00051 19.7 0.0 3.8 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.27 KOO26506.1 - 6.9e-16 56.2 0.0 0.00026 20.0 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.1 KOO26506.1 - 8.5e-10 38.6 0.0 0.095 12.8 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO26506.1 - 1.1e-07 31.3 0.1 0.014 15.0 0.0 4.0 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.1 KOO26506.1 - 0.00045 20.0 0.0 12 5.8 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain DUF3644 PF12358.3 KOO26506.1 - 0.073 13.3 0.1 1.6 9.0 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3644) zf-H2C2_2 PF13465.1 KOO26507.1 - 0.00011 22.2 0.1 0.00011 22.2 0.1 4.2 4 1 0 4 4 4 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 KOO26507.1 - 8.9 6.9 27.3 17 6.0 1.5 5.7 5 1 0 5 5 5 0 C2H2-type zinc finger TPT PF03151.11 KOO26508.1 - 4.1e-21 75.2 20.9 2.7e-20 72.5 7.2 2.9 2 1 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.15 KOO26508.1 - 9e-16 58.0 23.7 9e-10 38.6 3.5 2.5 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.6 KOO26508.1 - 2.3e-11 43.2 16.7 3.4e-11 42.6 11.6 1.3 1 0 0 1 1 1 1 UAA transporter family EmrE PF13536.1 KOO26508.1 - 9.2e-06 25.8 7.7 9.2e-06 25.8 5.3 3.6 2 1 1 3 3 3 1 Multidrug resistance efflux transporter UPF0546 PF10639.4 KOO26508.1 - 0.0041 16.9 1.2 0.0041 16.9 0.8 2.5 2 0 0 2 2 2 1 Uncharacterised protein family UPF0546 TPR_6 PF13174.1 KOO26508.1 - 0.13 12.7 0.2 0.5 10.9 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Nuc_sug_transp PF04142.10 KOO26508.1 - 0.23 10.5 10.8 0.11 11.5 2.4 2.4 2 0 0 2 2 2 0 Nucleotide-sugar transporter DUF3185 PF11381.3 KOO26508.1 - 1.3 8.8 6.1 6.8 6.5 0.2 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3185) Multi_Drug_Res PF00893.14 KOO26508.1 - 6.4 7.3 14.7 1.7 9.1 1.4 3.0 3 0 0 3 3 3 0 Small Multidrug Resistance protein ADH_zinc_N PF00107.21 KOO26510.1 - 2e-17 62.9 0.1 4.9e-17 61.6 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 KOO26510.1 - 3e-13 50.7 0.1 3.2e-12 47.4 0.1 2.3 2 1 0 2 2 2 1 Zinc-binding dehydrogenase Palm_thioest PF02089.10 KOO26511.1 - 3.1e-11 42.7 0.0 3.7e-11 42.5 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.15 KOO26511.1 - 0.00062 19.3 0.0 0.00073 19.1 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 KOO26511.1 - 0.034 14.0 0.1 0.034 14.0 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family ThiF PF00899.16 KOO26512.1 - 4.1e-12 46.1 0.0 2.7e-11 43.4 0.0 2.3 3 0 0 3 3 3 1 ThiF family Radial_spoke PF04712.7 KOO26513.1 - 3.7e-100 336.0 0.0 4.5e-100 335.7 0.0 1.0 1 0 0 1 1 1 1 Radial spokehead-like protein GrpE PF01025.14 KOO26514.1 - 1.8e-25 89.4 0.0 2.5e-25 88.9 0.0 1.2 1 0 0 1 1 1 1 GrpE FA_FANCE PF11510.3 KOO26515.1 - 5.2e-14 52.0 5.0 6.6e-14 51.6 3.4 1.1 1 0 0 1 1 1 1 Fanconi Anaemia group E protein FANCE DUF3072 PF11272.3 KOO26515.1 - 0.055 13.1 0.5 15 5.3 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3072) DUF1462 PF07315.6 KOO26516.1 - 0.16 11.9 0.4 1.5 8.8 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1462) Choline_transpo PF04515.7 KOO26517.1 - 4.4e-43 147.2 34.9 4.4e-43 147.2 24.2 2.7 3 1 0 3 3 3 1 Plasma-membrane choline transporter DLH PF01738.13 KOO26518.1 - 6.1e-32 110.6 0.0 9.2e-32 110.0 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 KOO26518.1 - 5.5e-11 42.4 0.0 8.4e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 KOO26518.1 - 5.1e-06 26.0 0.0 3.2e-05 23.4 0.0 1.9 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.2 KOO26518.1 - 3.8e-05 23.6 0.0 0.013 15.3 0.0 2.5 1 1 1 2 2 2 2 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 KOO26518.1 - 0.0019 17.4 0.0 0.08 12.1 0.0 2.2 1 1 1 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.8 KOO26518.1 - 0.013 15.0 0.1 0.32 10.5 0.0 2.5 2 1 1 3 3 3 0 alpha/beta hydrolase fold EF-hand_1 PF00036.27 KOO26518.1 - 0.058 12.7 0.1 0.16 11.3 0.0 1.8 1 0 0 1 1 1 0 EF hand TPP_enzyme_N PF02776.13 KOO26518.1 - 0.065 12.7 0.1 0.21 11.0 0.0 1.8 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain BAAT_C PF08840.6 KOO26518.1 - 0.1 12.2 0.1 6.6 6.3 0.0 2.6 1 1 2 3 3 3 0 BAAT / Acyl-CoA thioester hydrolase C terminal Pro_isomerase PF00160.16 KOO26521.1 - 7.8e-44 149.6 0.0 9.5e-44 149.3 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD EF-hand_6 PF13405.1 KOO26523.1 - 2.2e-09 36.3 4.4 0.00093 18.8 0.1 4.1 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.27 KOO26523.1 - 7.5e-09 34.2 2.7 0.0021 17.2 0.1 3.3 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.1 KOO26523.1 - 3.3e-08 33.5 3.0 0.007 16.4 0.1 3.8 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO26523.1 - 2.1e-07 30.4 4.8 0.0031 17.0 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO26523.1 - 2.4e-07 29.7 1.3 0.0058 15.9 0.1 3.3 2 0 0 2 2 2 2 EF hand LXG PF04740.7 KOO26523.1 - 6.8e-05 22.7 9.7 0.0008 19.2 0.9 2.8 3 0 0 3 3 3 2 LXG domain of WXG superfamily IL11 PF07400.6 KOO26523.1 - 0.16 11.4 0.2 0.34 10.3 0.0 1.5 2 0 0 2 2 2 0 Interleukin 11 Fasciclin PF02469.17 KOO26524.1 - 1.2e-35 122.2 0.1 1.9e-35 121.6 0.1 1.3 1 0 0 1 1 1 1 Fasciclin domain DUF725 PF05267.7 KOO26525.1 - 0.041 13.7 0.0 2.5 8.0 0.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF725) Filament PF00038.16 KOO26526.1 - 0.0038 16.7 0.5 0.0062 16.0 0.4 1.3 1 0 0 1 1 1 1 Intermediate filament protein DUF4140 PF13600.1 KOO26526.1 - 0.015 15.7 0.6 0.015 15.7 0.4 3.0 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) SseB PF07179.7 KOO26526.1 - 1.2 8.9 6.0 2.5 7.9 0.1 2.7 2 1 1 3 3 3 0 SseB protein N-terminal domain Nop10p PF04135.7 KOO26527.1 - 5.8e-21 73.9 0.2 7.1e-21 73.6 0.1 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family TPR_11 PF13414.1 KOO26528.1 - 1.6e-13 50.0 1.1 6.3e-07 28.9 0.0 2.3 1 1 0 2 2 2 2 TPR repeat TPR_14 PF13428.1 KOO26528.1 - 4.9e-12 45.3 9.1 0.00046 20.5 0.9 3.3 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO26528.1 - 1e-10 40.6 3.0 0.0024 17.6 0.1 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO26528.1 - 1.3e-10 41.6 7.3 5.7e-06 26.8 0.4 2.4 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO26528.1 - 9.6e-08 31.7 4.7 0.0029 17.4 0.3 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO26528.1 - 2.5e-07 30.9 3.3 0.00084 19.6 0.5 2.3 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO26528.1 - 3.8e-06 26.6 1.0 0.26 11.5 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO26528.1 - 6.1e-06 25.6 0.1 0.048 13.2 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_21 PF09976.4 KOO26528.1 - 1.1e-05 25.4 0.5 1.5e-05 24.9 0.3 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO26528.1 - 1.3e-05 24.5 0.0 2.6 8.0 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_15 PF13429.1 KOO26528.1 - 1.4e-05 24.3 1.3 0.029 13.4 0.1 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO26528.1 - 4.4e-05 23.3 3.9 0.0005 19.9 1.2 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO26528.1 - 0.0011 18.6 2.3 0.28 11.0 0.2 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat NARP1 PF12569.3 KOO26528.1 - 0.0028 16.4 0.0 1.6 7.3 0.0 2.0 1 1 1 2 2 2 2 NMDA receptor-regulated protein 1 TPR_6 PF13174.1 KOO26528.1 - 0.016 15.6 1.1 1.6 9.3 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.13 KOO26528.1 - 0.4 10.5 3.9 6.9 6.6 0.4 2.6 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain RRM_1 PF00076.17 KOO26529.1 - 3.4e-16 58.6 0.1 4.7e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO26529.1 - 1.1e-12 47.7 0.0 1.6e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO26529.1 - 2.5e-10 40.0 0.1 3.6e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 PF10243.4 KOO26529.1 - 1 7.7 11.0 1.2 7.5 7.6 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 GIDA PF01134.17 KOO26530.1 - 4.9e-108 361.4 0.0 9.3e-108 360.5 0.0 1.5 1 1 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc_3 PF13932.1 KOO26530.1 - 2.3e-18 66.0 0.5 1.1e-17 63.8 0.1 2.3 2 0 0 2 2 2 1 GidA associated domain 3 Exostosin PF03016.10 KOO26531.1 - 1.8e-12 46.9 0.0 2.9e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 Exostosin family Pkinase PF00069.20 KOO26533.1 - 5.3e-66 222.4 0.0 7.1e-66 222.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO26533.1 - 5.2e-28 97.8 0.0 1.7e-27 96.1 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO26533.1 - 0.00053 19.0 0.0 0.00093 18.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOO26533.1 - 0.0021 17.1 0.0 0.0039 16.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 KOO26533.1 - 0.0057 16.0 0.0 0.012 14.9 0.0 1.5 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 KOO26533.1 - 0.031 14.0 1.2 0.093 12.4 0.1 2.1 2 1 1 3 3 3 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 KOO26533.1 - 0.047 12.4 0.0 0.072 11.8 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF3250 PF11618.3 KOO26535.1 - 1.4e-30 105.6 0.4 1.2e-21 76.8 0.0 4.0 4 0 0 4 4 4 2 Protein of unknown function (DUF3250) C2 PF00168.25 KOO26535.1 - 0.00089 19.0 0.0 0.0092 15.8 0.0 2.4 2 0 0 2 2 2 1 C2 domain AAA PF00004.24 KOO26536.1 - 7.9e-28 97.2 0.0 6.5e-27 94.3 0.0 2.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KOO26536.1 - 9.8e-06 25.3 0.0 5.9e-05 22.8 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOO26536.1 - 4.9e-05 23.3 0.5 0.00037 20.5 0.3 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 KOO26536.1 - 9.9e-05 22.4 0.0 0.0052 16.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 KOO26536.1 - 0.00018 21.4 0.0 0.0006 19.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO26536.1 - 0.00023 21.9 0.0 0.00039 21.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 KOO26536.1 - 0.00024 20.2 0.0 0.00035 19.7 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 KOO26536.1 - 0.00037 20.2 1.2 0.0012 18.5 0.8 2.0 1 1 0 1 1 1 1 Part of AAA domain IstB_IS21 PF01695.12 KOO26536.1 - 0.00093 18.6 0.0 0.0015 18.0 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.16 KOO26536.1 - 0.0021 17.2 0.1 0.0042 16.2 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 KOO26536.1 - 0.0034 16.8 0.9 0.071 12.4 0.6 2.5 1 1 0 1 1 1 1 AAA domain PhoH PF02562.11 KOO26536.1 - 0.0039 16.4 0.0 0.0066 15.6 0.0 1.3 1 0 0 1 1 1 1 PhoH-like protein TIP49 PF06068.8 KOO26536.1 - 0.0046 15.7 0.0 0.0065 15.2 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus AAA_28 PF13521.1 KOO26536.1 - 0.01 15.8 0.0 0.018 14.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.1 KOO26536.1 - 0.013 15.0 0.0 0.018 14.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 KOO26536.1 - 0.02 14.3 0.0 0.042 13.3 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.7 KOO26536.1 - 0.029 13.4 0.0 0.051 12.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Sigma54_activ_2 PF14532.1 KOO26536.1 - 0.031 14.3 0.0 0.051 13.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain TPR_14 PF13428.1 KOO26536.1 - 0.065 13.8 1.6 15 6.5 0.0 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat NACHT PF05729.7 KOO26536.1 - 0.093 12.3 0.0 0.53 9.9 0.0 2.1 2 0 0 2 2 2 0 NACHT domain GFO_IDH_MocA PF01408.17 KOO26537.1 - 4.8e-19 69.0 0.3 9.3e-19 68.1 0.2 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Pyr_redox PF00070.22 KOO26537.1 - 0.081 13.3 0.2 0.81 10.1 0.0 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DUF4094 PF13334.1 KOO26538.1 - 1.1 9.6 3.0 0.79 10.1 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) DUF3638 PF12340.3 KOO26539.1 - 9.7e-26 90.1 0.1 2.8e-21 75.5 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3638) DUF3645 PF12359.3 KOO26539.1 - 5.6e-16 57.3 0.1 1.9e-15 55.6 0.1 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) EF-hand_6 PF13405.1 KOO26539.1 - 1.5e-08 33.8 0.1 0.019 14.7 0.0 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.1 KOO26539.1 - 7.7e-08 32.3 0.0 0.0026 17.8 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO26539.1 - 8.6e-07 27.8 0.0 0.011 14.9 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO26539.1 - 3.7e-05 23.2 0.0 0.032 13.8 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO26539.1 - 0.00019 20.6 0.0 0.0031 16.7 0.0 2.6 2 0 0 2 2 2 1 EF hand DUF946 PF06101.6 KOO26539.1 - 0.28 9.1 0.0 0.42 8.5 0.0 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF946) ResIII PF04851.10 KOO26539.1 - 0.39 10.5 0.0 0.7 9.6 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Glu_cyclase_2 PF05096.7 KOO26540.1 - 1.2e-33 116.3 0.0 1.4e-33 116.0 0.0 1.0 1 0 0 1 1 1 1 Glutamine cyclotransferase Ank_2 PF12796.2 KOO26541.1 - 3e-49 165.2 31.6 1.1e-19 70.4 2.3 3.8 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 KOO26541.1 - 1.9e-32 109.4 28.6 3.8e-08 32.7 0.0 7.5 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.1 KOO26541.1 - 8.1e-26 89.4 20.4 1.7e-10 40.8 0.7 5.9 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO26541.1 - 6.5e-25 87.0 12.1 3.5e-08 33.7 0.1 6.3 2 1 5 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO26541.1 - 6.7e-20 69.2 12.7 0.00043 20.2 0.0 7.3 7 0 0 7 7 7 4 Ankyrin repeat IQ PF00612.22 KOO26542.1 - 0.0017 17.8 3.1 0.0048 16.4 2.2 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif C2 PF00168.25 KOO26543.1 - 8.7e-23 79.9 0.0 2.5e-12 46.4 0.0 2.6 2 0 0 2 2 2 2 C2 domain EF-hand_5 PF13202.1 KOO26543.1 - 3e-10 38.9 0.5 5.3e-05 22.3 0.1 3.4 3 0 0 3 3 3 2 EF hand EF-hand_1 PF00036.27 KOO26543.1 - 3.2e-10 38.5 0.1 0.00062 18.8 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 KOO26543.1 - 5.6e-09 36.0 0.1 2.5e-08 33.9 0.0 2.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO26543.1 - 4.4e-08 32.3 0.1 0.0052 16.5 0.0 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO26543.1 - 2.6e-06 26.9 0.4 1e-05 25.0 0.3 2.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_10 PF14788.1 KOO26543.1 - 0.003 17.2 0.1 0.017 14.7 0.0 2.3 1 1 1 2 2 2 1 EF hand EF-hand_4 PF12763.2 KOO26543.1 - 0.14 11.8 0.3 7.4 6.3 0.0 2.6 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand DnaJ PF00226.26 KOO26544.1 - 1.8e-15 56.3 0.6 9e-15 54.1 0.1 2.4 3 0 0 3 3 3 1 DnaJ domain PBP1_TM PF14812.1 KOO26544.1 - 4.2 7.7 9.4 5.9 7.2 0.6 2.8 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Arm PF00514.18 KOO26545.1 - 3.5e-27 93.2 13.5 5.9e-06 25.9 0.1 5.8 5 0 0 5 5 5 5 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO26545.1 - 9.4e-07 29.0 35.5 0.00043 20.4 9.1 4.7 2 1 2 5 5 5 4 HEAT repeats HEAT PF02985.17 KOO26545.1 - 2.7e-05 23.8 8.9 0.00099 18.9 0.0 5.8 6 0 0 6 6 6 1 HEAT repeat Dynamin_N PF00350.18 KOO26545.1 - 0.00035 20.4 0.0 0.00059 19.6 0.0 1.3 1 0 0 1 1 1 1 Dynamin family Vac14_Fab1_bd PF12755.2 KOO26545.1 - 0.095 13.1 0.0 89 3.5 0.0 3.9 3 1 1 4 4 4 0 Vacuolar 14 Fab1-binding region Succ_CoA_lig PF13607.1 KOO26545.1 - 1.4 8.5 19.2 1.4 8.5 0.7 4.5 2 1 2 4 4 4 0 Succinyl-CoA ligase like flavodoxin domain Sel1 PF08238.7 KOO26546.1 - 1.4e-15 57.3 12.8 6.8e-07 29.7 0.2 4.6 4 0 0 4 4 4 3 Sel1 repeat SET PF00856.23 KOO26547.1 - 3.5e-10 40.4 0.0 9.1e-08 32.5 0.0 2.3 1 1 0 1 1 1 1 SET domain SAF PF08666.7 KOO26547.1 - 0.028 14.7 0.0 0.59 10.5 0.0 2.3 2 0 0 2 2 2 0 SAF domain Dpy-30 PF05186.8 KOO26547.1 - 0.13 11.7 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Dpy-30 motif LMBR1 PF04791.11 KOO26548.1 - 1.1e-42 146.2 23.7 4.7e-30 104.6 3.1 2.1 2 0 0 2 2 2 2 LMBR1-like membrane protein FAD_binding_1 PF00667.15 KOO26549.1 - 1.2e-40 139.3 0.0 1.5e-40 138.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 KOO26549.1 - 3.3e-26 91.9 0.0 6.1e-26 91.1 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 KOO26549.1 - 2.8e-17 63.2 0.0 5.4e-17 62.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Gly-zipper_OmpA PF13436.1 KOO26550.1 - 0.0081 15.8 0.9 0.19 11.3 0.1 2.6 2 0 0 2 2 2 1 Glycine-zipper containing OmpA-like membrane domain Ribonuc_red_lgC PF02867.10 KOO26551.1 - 2.9e-216 719.2 0.0 3.8e-216 718.8 0.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 KOO26551.1 - 9.4e-25 86.2 0.0 2.2e-24 85.0 0.0 1.7 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 KOO26551.1 - 1.8e-14 53.9 0.0 5.3e-14 52.4 0.0 1.9 2 0 0 2 2 2 1 ATP cone domain NRDD PF13597.1 KOO26551.1 - 0.011 13.8 0.0 0.018 13.1 0.0 1.2 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase COXG PF06240.8 KOO26556.1 - 0.026 14.1 0.0 0.049 13.2 0.0 1.4 2 0 0 2 2 2 0 Carbon monoxide dehydrogenase subunit G (CoxG) Cellulase PF00150.13 KOO26557.1 - 3.8e-15 55.8 0.0 6.2e-14 51.8 0.0 2.7 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_42 PF02449.10 KOO26557.1 - 1.7e-06 27.4 0.0 4e-06 26.1 0.0 1.5 2 0 0 2 2 2 1 Beta-galactosidase Glyco_hydro_35 PF01301.14 KOO26557.1 - 0.00018 20.9 0.0 0.00036 19.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 DUF1777 PF08648.7 KOO26557.1 - 0.0094 15.7 1.0 0.014 15.0 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1777) EF-hand_7 PF13499.1 KOO26557.1 - 0.024 14.7 0.2 0.052 13.6 0.1 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.1 KOO26557.1 - 0.075 12.9 0.1 0.21 11.5 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain DUF2922 PF11148.3 KOO26557.1 - 0.13 11.9 1.8 0.29 10.8 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2922) Cyto_heme_lyase PF01265.12 KOO26558.1 - 2.3e-67 227.3 0.0 3.8e-67 226.6 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase MFS_1 PF07690.11 KOO26559.1 - 0.001 17.8 4.2 0.0012 17.6 2.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Claudin_2 PF13903.1 KOO26559.1 - 0.037 13.7 1.0 0.058 13.0 0.7 1.5 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Sugar_tr PF00083.19 KOO26559.1 - 0.052 12.1 1.5 0.056 12.0 1.1 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter Peptidase_C2 PF00648.16 KOO26560.1 - 4.3e-72 242.6 0.0 6.7e-72 241.9 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.17 KOO26560.1 - 2.5e-29 101.8 0.0 7.7e-12 45.0 0.0 3.4 2 1 1 3 3 3 3 Calpain large subunit, domain III HATPase_c_3 PF13589.1 KOO26561.1 - 0.035 13.7 0.0 0.069 12.8 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase EF-hand_6 PF13405.1 KOO26562.1 - 1.1e-21 74.7 0.5 1.2e-05 24.8 0.0 4.8 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.27 KOO26562.1 - 1.6e-20 70.8 5.5 2.9e-06 26.1 0.0 4.6 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.1 KOO26562.1 - 3.4e-17 62.3 1.4 2e-08 34.2 0.1 3.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO26562.1 - 4.2e-15 54.3 3.8 1.7e-05 23.9 0.2 4.0 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 KOO26562.1 - 1.1e-13 50.5 2.5 3e-07 29.9 0.2 3.7 2 1 1 3 3 3 3 EF-hand domain pair RelB_N PF12910.2 KOO26563.1 - 0.065 12.6 0.8 2.6 7.4 0.0 2.9 3 0 0 3 3 3 0 Antitoxin of toxin-antitoxin stability system N-terminal HXXSHH PF07586.6 KOO26563.1 - 0.074 11.9 0.1 0.076 11.9 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) AAA_11 PF13086.1 KOO26564.1 - 3.9e-53 180.4 0.0 5.1e-53 180.0 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.1 KOO26564.1 - 8.5e-16 58.1 0.8 1.8e-14 53.7 0.5 2.3 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOO26564.1 - 4e-13 48.9 4.3 1.7e-12 46.9 1.6 2.7 2 0 0 2 2 2 1 Part of AAA domain AAA_12 PF13087.1 KOO26564.1 - 2.4e-10 40.1 0.0 4.2e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 KOO26564.1 - 3.1e-06 26.8 0.0 0.04 13.4 0.0 2.2 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.1 KOO26564.1 - 4.9e-05 23.4 0.2 0.0016 18.6 0.1 2.5 1 1 0 1 1 1 1 AAA domain TrwB_AAD_bind PF10412.4 KOO26564.1 - 0.00041 19.0 0.0 0.00073 18.2 0.0 1.3 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain Zot PF05707.7 KOO26564.1 - 0.00052 19.5 0.0 0.0031 17.0 0.0 2.0 2 0 0 2 2 2 1 Zonular occludens toxin (Zot) AAA_16 PF13191.1 KOO26564.1 - 0.00055 19.9 3.5 0.00091 19.2 1.3 2.3 2 1 0 2 2 1 1 AAA ATPase domain PIF1 PF05970.9 KOO26564.1 - 0.00058 18.9 0.0 0.27 10.1 0.0 2.2 2 0 0 2 2 2 2 PIF1-like helicase DUF2075 PF09848.4 KOO26564.1 - 0.00082 18.4 0.0 0.18 10.7 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.24 KOO26564.1 - 0.00097 19.3 0.1 0.0019 18.4 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MobB PF03205.9 KOO26564.1 - 0.0018 17.9 0.0 0.004 16.8 0.0 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B DEAD PF00270.24 KOO26564.1 - 0.0023 17.4 0.0 0.0057 16.1 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_28 PF13521.1 KOO26564.1 - 0.0036 17.2 0.2 0.019 14.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 KOO26564.1 - 0.0043 16.9 0.1 0.019 14.8 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 KOO26564.1 - 0.0044 16.4 0.0 0.014 14.7 0.0 1.8 2 0 0 2 2 1 1 AAA domain Helicase_RecD PF05127.9 KOO26564.1 - 0.0069 16.0 5.4 0.16 11.6 0.1 3.2 3 1 0 3 3 3 1 Helicase ArgK PF03308.11 KOO26564.1 - 0.0089 14.8 0.1 0.017 13.9 0.1 1.4 1 0 0 1 1 1 1 ArgK protein UvrD-helicase PF00580.16 KOO26564.1 - 0.01 15.1 0.1 0.014 14.7 0.0 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_17 PF13207.1 KOO26564.1 - 0.012 16.4 0.0 0.051 14.3 0.0 2.1 2 0 0 2 2 1 0 AAA domain FtsK_SpoIIIE PF01580.13 KOO26564.1 - 0.022 14.2 0.0 0.053 12.9 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_18 PF13238.1 KOO26564.1 - 0.023 14.9 0.1 0.11 12.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.12 KOO26564.1 - 0.025 13.9 0.0 0.06 12.7 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Herpes_ori_bp PF02399.10 KOO26564.1 - 0.03 12.2 0.0 0.048 11.6 0.0 1.2 1 0 0 1 1 1 0 Origin of replication binding protein CbiA PF01656.18 KOO26564.1 - 0.034 13.5 0.4 0.12 11.8 0.2 1.9 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_10 PF12846.2 KOO26564.1 - 0.035 13.5 0.0 0.096 12.1 0.0 1.7 2 0 0 2 2 2 0 AAA-like domain cobW PF02492.14 KOO26564.1 - 0.037 13.4 0.1 0.2 11.1 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain T2SE PF00437.15 KOO26564.1 - 0.054 12.3 0.0 0.082 11.7 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein KaiC PF06745.8 KOO26564.1 - 0.065 12.3 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 KaiC NTPase_1 PF03266.10 KOO26564.1 - 0.11 12.1 0.1 0.5 10.0 0.0 2.0 2 0 0 2 2 2 0 NTPase ResIII PF04851.10 KOO26564.1 - 0.13 12.1 0.0 0.56 10.0 0.0 1.8 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.9 KOO26564.1 - 0.13 12.0 0.1 0.38 10.5 0.1 1.7 2 0 0 2 2 2 0 Flavivirus DEAD domain AAA_29 PF13555.1 KOO26564.1 - 0.16 11.5 0.0 0.4 10.2 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.17 KOO26564.1 - 0.16 12.1 0.0 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.1 KOO26564.1 - 0.18 11.6 0.0 0.41 10.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.10 KOO26564.1 - 0.2 10.3 0.1 0.45 9.1 0.0 1.5 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein PspA_IM30 PF04012.7 KOO26565.1 - 2.4e-42 144.7 30.8 3.5e-42 144.2 21.3 1.2 1 0 0 1 1 1 1 PspA/IM30 family LAGLIDADG_WhiA PF14527.1 KOO26565.1 - 0.032 14.0 0.6 0.083 12.7 0.4 1.8 1 0 0 1 1 1 0 WhiA LAGLIDADG-like domain DUF2795 PF11387.3 KOO26565.1 - 0.14 12.0 0.5 0.34 10.7 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2795) DUF465 PF04325.8 KOO26565.1 - 0.77 9.5 4.8 5.2 6.8 0.0 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF465) Snapin_Pallidin PF14712.1 KOO26565.1 - 0.78 10.0 10.0 1.5 9.1 0.0 3.5 3 1 0 3 3 3 0 Snapin/Pallidin Ribosomal_S30AE PF02482.14 KOO26565.1 - 3.6 8.1 9.7 0.11 12.9 1.5 2.4 3 1 0 3 3 3 0 Sigma 54 modulation protein / S30EA ribosomal protein Nup54 PF13874.1 KOO26565.1 - 3.9 7.1 18.2 0.082 12.5 4.2 2.4 3 0 0 3 3 3 0 Nucleoporin complex subunit 54 PP_kinase_N PF13089.1 KOO26565.1 - 8.7 6.4 8.4 31 4.7 1.8 3.3 2 1 1 3 3 3 0 Polyphosphate kinase N-terminal domain DUF3391 PF11871.3 KOO26565.1 - 9.2 6.4 16.8 2.2 8.4 0.6 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF3391) PIF1 PF05970.9 KOO26568.1 - 2.9e-13 49.5 0.0 6.1e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 PIF1-like helicase SAP PF02037.22 KOO26568.1 - 5.5e-07 28.9 0.5 1.1e-06 28.0 0.3 1.5 1 0 0 1 1 1 1 SAP domain AAA_16 PF13191.1 KOO26568.1 - 0.00088 19.3 1.1 0.002 18.1 0.0 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.1 KOO26568.1 - 0.0017 17.9 0.0 0.014 15.0 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KOO26568.1 - 0.0025 17.5 1.6 0.011 15.4 0.9 2.4 1 1 0 1 1 1 1 Part of AAA domain Arch_ATPase PF01637.13 KOO26568.1 - 0.0056 16.4 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase Arf PF00025.16 KOO26568.1 - 0.25 10.5 0.0 0.43 9.8 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family SH3_9 PF14604.1 KOO26570.1 - 9.9e-25 85.8 1.4 0.00018 21.0 0.0 6.5 6 0 0 6 6 6 6 Variant SH3 domain SH3_2 PF07653.12 KOO26570.1 - 2e-18 65.5 0.1 1.4e-05 24.4 0.0 5.7 6 0 0 6 6 6 4 Variant SH3 domain SH3_1 PF00018.23 KOO26570.1 - 3.8e-18 64.5 0.0 0.0041 16.4 0.0 6.5 6 0 0 6 6 6 5 SH3 domain AAA_12 PF13087.1 KOO26573.1 - 2.4e-44 151.1 0.0 4.2e-44 150.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 KOO26573.1 - 2.7e-35 122.0 0.0 2.3e-32 112.4 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.1 KOO26573.1 - 7.4e-15 55.0 1.3 3.3e-14 52.9 0.0 2.6 3 1 0 3 3 3 1 AAA domain Viral_helicase1 PF01443.13 KOO26573.1 - 3.1e-10 39.9 0.0 0.0067 15.9 0.0 3.4 2 1 1 3 3 3 3 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.1 KOO26573.1 - 4e-08 32.8 1.0 4e-08 32.8 0.7 3.0 2 0 0 2 2 2 1 Part of AAA domain Helicase_RecD PF05127.9 KOO26573.1 - 2.1e-05 24.2 0.1 7.5e-05 22.4 0.1 1.9 1 1 0 1 1 1 1 Helicase AAA_25 PF13481.1 KOO26573.1 - 0.00035 20.0 0.1 0.0015 18.0 0.0 2.0 3 0 0 3 3 2 1 AAA domain UvrD_C_2 PF13538.1 KOO26573.1 - 0.00047 20.2 0.0 0.001 19.1 0.0 1.5 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_16 PF13191.1 KOO26573.1 - 0.00066 19.7 0.4 0.00066 19.7 0.3 2.8 4 1 0 4 4 3 1 AAA ATPase domain Dna2 PF08696.6 KOO26573.1 - 0.00093 18.5 0.0 0.0014 17.9 0.0 1.2 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_10 PF12846.2 KOO26573.1 - 0.0019 17.7 0.0 0.0037 16.7 0.0 1.4 1 0 0 1 1 1 1 AAA-like domain UvrD_C PF13361.1 KOO26573.1 - 0.005 16.3 0.0 0.014 14.8 0.0 1.7 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain MobB PF03205.9 KOO26573.1 - 0.013 15.2 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B ArgK PF03308.11 KOO26573.1 - 0.018 13.8 0.3 0.038 12.7 0.0 1.6 2 0 0 2 2 2 0 ArgK protein AAA_29 PF13555.1 KOO26573.1 - 0.025 14.0 0.0 0.075 12.5 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain NTPase_1 PF03266.10 KOO26573.1 - 0.049 13.3 0.0 0.26 10.9 0.0 2.0 2 0 0 2 2 2 0 NTPase AAA_5 PF07728.9 KOO26573.1 - 0.053 13.2 0.1 0.15 11.7 0.0 1.8 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 KOO26573.1 - 0.057 13.3 0.0 0.17 11.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 KOO26573.1 - 0.071 13.0 0.0 0.26 11.2 0.0 1.9 2 0 0 2 2 1 0 50S ribosome-binding GTPase DUF2075 PF09848.4 KOO26573.1 - 0.073 12.0 0.0 0.33 9.8 0.0 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.1 KOO26573.1 - 0.082 13.0 0.1 0.26 11.4 0.0 1.9 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.17 KOO26573.1 - 0.16 11.4 0.2 0.48 9.8 0.1 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Miro PF08477.8 KOO26573.1 - 0.19 12.2 0.1 0.62 10.5 0.0 1.9 2 0 0 2 2 1 0 Miro-like protein UvrD-helicase PF00580.16 KOO26573.1 - 0.21 10.8 0.0 0.33 10.2 0.0 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain PIF1 PF05970.9 KOO26573.1 - 0.21 10.4 0.0 4.5 6.1 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase NB-ARC PF00931.17 KOO26573.1 - 0.42 9.4 0.0 0.7 8.7 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain OTU PF02338.14 KOO26574.1 - 0.017 15.6 0.1 0.068 13.7 0.0 2.0 2 0 0 2 2 2 0 OTU-like cysteine protease Exostosin PF03016.10 KOO26576.1 - 1.1e-29 103.4 0.2 1.7e-29 102.8 0.1 1.2 1 0 0 1 1 1 1 Exostosin family IQ PF00612.22 KOO26577.1 - 6.5e-12 43.9 9.8 0.0017 17.8 0.1 3.9 3 0 0 3 3 3 3 IQ calmodulin-binding motif DUF773 PF05600.7 KOO26577.1 - 0.016 14.0 6.5 0.022 13.5 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF773) Ank_5 PF13857.1 KOO26578.1 - 6.5e-13 48.4 5.7 3.6e-07 30.2 0.1 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO26578.1 - 1.3e-11 44.6 0.7 4.8e-11 42.8 0.4 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO26578.1 - 1.6e-10 40.2 5.2 7.8e-05 22.2 0.2 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOO26578.1 - 4.6e-07 30.1 5.6 9.5e-06 25.9 0.6 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO26578.1 - 2.2e-05 24.2 4.8 0.039 14.1 0.2 3.4 3 0 0 3 3 3 2 Ankyrin repeat AAA_13 PF13166.1 KOO26578.1 - 0.48 8.8 4.4 0.72 8.2 3.1 1.2 1 0 0 1 1 1 0 AAA domain DUF1664 PF07889.7 KOO26578.1 - 1 9.1 4.3 0.38 10.5 0.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4472 PF14739.1 KOO26578.1 - 1.7 9.1 11.9 0.91 10.0 2.6 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4472) HXXSHH PF07586.6 KOO26578.1 - 3.6 6.4 6.9 6.2 5.6 4.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) DnaJ PF00226.26 KOO26578.1 - 5.3 6.8 6.0 2.6 7.8 0.3 2.6 2 0 0 2 2 2 0 DnaJ domain Lipase_3 PF01764.20 KOO26579.1 - 2.8e-21 75.5 0.0 5.8e-21 74.5 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_3 PF07859.8 KOO26579.1 - 8.5e-06 25.4 0.1 2.1e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 KOO26579.1 - 0.00021 21.2 0.1 0.00081 19.3 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family PLA2_B PF01735.13 KOO26579.1 - 0.00033 18.9 0.2 0.00033 18.9 0.2 1.6 2 0 0 2 2 2 1 Lysophospholipase catalytic domain Abhydrolase_5 PF12695.2 KOO26579.1 - 0.0012 18.5 0.0 0.0032 17.2 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO26579.1 - 0.0015 18.1 0.0 0.0034 16.9 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold EF-hand_7 PF13499.1 KOO26579.1 - 0.0016 18.4 0.0 0.0044 17.1 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO26579.1 - 0.0034 17.1 0.1 6.8 6.8 0.0 3.3 1 1 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO26579.1 - 0.0088 15.2 0.0 1.9 7.9 0.0 2.8 2 0 0 2 2 2 1 EF hand DUF2974 PF11187.3 KOO26579.1 - 0.044 13.1 0.0 0.8 9.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) AXE1 PF05448.7 KOO26579.1 - 0.083 11.3 0.0 0.14 10.6 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Esterase PF00756.15 KOO26579.1 - 0.13 11.6 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 Putative esterase Patatin PF01734.17 KOO26579.1 - 0.17 11.8 1.5 0.5 10.2 0.0 2.4 3 0 0 3 3 3 0 Patatin-like phospholipase DUF4217 PF13959.1 KOO26580.1 - 1.7e-20 72.3 0.1 3.3e-20 71.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.26 KOO26580.1 - 4.7e-17 61.6 0.0 1.3e-16 60.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOO26580.1 - 2e-15 56.6 0.0 4e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase EGF_CA PF07645.10 KOO26581.1 - 2.4 8.1 11.2 5.4 7.1 7.7 1.6 1 0 0 1 1 1 0 Calcium-binding EGF domain TTL PF03133.10 KOO26582.1 - 1.4e-28 99.7 0.0 3e-28 98.5 0.0 1.5 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family DUF4461 PF14688.1 KOO26583.1 - 3.8e-08 33.0 0.0 4.3e-08 32.8 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4461) NAD_binding_1 PF00175.16 KOO26584.1 - 2.5e-09 37.6 0.0 3.8e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Y_phosphatase3 PF13350.1 KOO26585.1 - 1.1e-22 81.0 0.0 1.4e-21 77.4 0.0 2.2 2 1 0 2 2 2 1 Tyrosine phosphatase family Y_phosphatase3C PF13348.1 KOO26585.1 - 1.1e-08 35.0 0.0 3.3e-08 33.5 0.0 1.9 1 0 0 1 1 1 1 Tyrosine phosphatase family C-terminal region Y_phosphatase2 PF03162.8 KOO26585.1 - 7.5e-06 25.4 0.0 1.1e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 KOO26585.1 - 0.00028 20.3 0.0 0.00037 19.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Myotub-related PF06602.9 KOO26585.1 - 0.0079 15.0 0.0 0.01 14.6 0.0 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DSPc PF00782.15 KOO26585.1 - 0.018 14.6 0.0 0.029 13.9 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain BACK PF07707.10 KOO26587.1 - 2.9e-19 68.7 0.2 3.9e-17 61.9 0.0 2.2 2 0 0 2 2 2 2 BTB And C-terminal Kelch BTB PF00651.26 KOO26587.1 - 1.1e-10 41.5 0.1 1.8e-10 40.7 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain IL17_R_N PF15037.1 KOO26587.1 - 0.014 14.4 0.0 0.02 13.9 0.0 1.2 1 0 0 1 1 1 0 Interleukin-17 receptor extracellular region Ras PF00071.17 KOO26588.1 - 2.1e-56 189.7 0.1 2.5e-56 189.5 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO26588.1 - 3.7e-20 72.6 0.1 5.5e-20 72.0 0.1 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO26588.1 - 6.4e-16 58.0 0.0 7.8e-16 57.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 KOO26588.1 - 1.4e-08 34.3 0.1 7.9e-08 31.9 0.1 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 KOO26588.1 - 3.4e-08 32.9 0.1 4.3e-08 32.5 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 KOO26588.1 - 9.4e-06 25.5 0.0 1.2e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 KOO26588.1 - 0.00055 19.2 0.0 0.00084 18.5 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.12 KOO26588.1 - 0.0046 16.5 0.0 0.021 14.4 0.0 1.8 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein PduV-EutP PF10662.4 KOO26588.1 - 0.021 14.3 0.2 0.08 12.4 0.1 1.9 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.18 KOO26588.1 - 0.13 12.0 0.4 3.8 7.3 0.0 2.3 2 1 1 3 3 3 0 Dynamin family P12 PF12669.2 KOO26589.1 - 2.3 8.4 7.8 1.7 8.9 4.8 1.4 1 1 0 1 1 1 0 Virus attachment protein p12 family PAPS_reduct PF01507.14 KOO26590.1 - 1.3e-27 96.7 0.0 3.5e-18 66.0 0.0 2.1 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family Glyco_hydro_3_C PF01915.17 KOO26591.1 - 3.7e-34 118.2 0.3 7.4e-34 117.2 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.16 KOO26591.1 - 5e-29 101.2 0.0 9.2e-29 100.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.1 KOO26591.1 - 5e-09 35.9 0.0 1.4e-08 34.5 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF11 PF01345.13 KOO26591.1 - 0.0036 17.3 1.6 0.015 15.3 1.1 2.1 1 0 0 1 1 1 1 Domain of unknown function DUF11 Glyco_hydro_3 PF00933.16 KOO26592.1 - 3.6e-20 72.1 0.0 5.4e-20 71.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain WSC PF01822.14 KOO26592.1 - 4.1e-15 55.4 12.5 8.6e-15 54.4 8.7 1.5 1 0 0 1 1 1 1 WSC domain Pkinase PF00069.20 KOO26593.1 - 1.6e-17 63.5 0.0 2.8e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain CHAT PF12770.2 KOO26593.1 - 1.3e-05 24.4 0.0 3.4e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 CHAT domain Pkinase_Tyr PF07714.12 KOO26593.1 - 0.0001 21.4 0.0 0.00022 20.3 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO26593.1 - 0.003 16.5 0.0 0.0073 15.2 0.0 1.6 1 0 0 1 1 1 1 Kinase-like SPX PF03105.14 KOO26594.1 - 0.015 15.1 0.2 0.015 15.1 0.2 4.9 4 2 0 4 4 4 0 SPX domain Phage_XkdX PF09693.5 KOO26595.1 - 0.09 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Phage uncharacterised protein (Phage_XkdX) SURF4 PF02077.10 KOO26596.1 - 1.5e-12 47.4 1.5 6e-12 45.5 1.0 1.7 1 1 0 1 1 1 1 SURF4 family ShK PF01549.19 KOO26596.1 - 2.4e-08 34.2 11.3 0.00029 21.1 1.0 2.3 2 0 0 2 2 2 2 ShK domain-like Glyco_transf_10 PF00852.14 KOO26598.1 - 0.00071 18.2 0.0 0.00094 17.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) DEAD PF00270.24 KOO26599.1 - 1.6e-37 128.5 0.0 1.3e-36 125.5 0.0 2.2 1 1 2 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO26599.1 - 6.2e-26 90.0 0.0 1.7e-25 88.6 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Utp21 PF04192.7 KOO26601.1 - 1.1e-11 44.3 3.7 1.1e-11 44.3 2.6 3.0 2 1 1 3 3 3 2 Utp21 specific WD40 associated putative domain Ribosomal_L7Ae PF01248.21 KOO26602.1 - 1.9e-19 68.9 0.2 2.3e-14 52.6 0.0 2.2 2 0 0 2 2 2 2 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family EF-hand_1 PF00036.27 KOO26603.1 - 1.1e-15 55.6 3.7 4.6e-07 28.6 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 KOO26603.1 - 4.4e-15 54.1 1.2 4.5e-06 26.0 0.0 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.1 KOO26603.1 - 5.7e-12 45.6 2.9 0.00034 20.7 0.0 3.5 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO26603.1 - 4.6e-07 29.3 5.0 3.1e-05 23.5 0.3 3.6 2 2 2 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO26603.1 - 1.7e-05 23.8 0.3 1.7e-05 23.8 0.2 3.6 4 0 0 4 4 4 1 EF hand KxDL PF10241.4 KOO26603.1 - 0.17 11.8 0.4 1.7 8.5 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein EF-hand_4 PF12763.2 KOO26603.1 - 1.2 8.9 3.1 12 5.7 0.1 2.8 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand PI3_PI4_kinase PF00454.22 KOO26604.1 - 9.5e-24 84.1 0.0 1.6e-21 76.8 0.0 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PH PF00169.24 KOO26604.1 - 1.6e-07 31.4 0.0 2.8e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 KOO26604.1 - 0.0029 17.8 0.2 0.006 16.8 0.2 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.1 KOO26604.1 - 0.0042 17.1 0.0 0.009 16.0 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain DUF2870 PF11069.3 KOO26605.1 - 0.1 12.6 0.6 0.17 11.9 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2870) MS_channel PF00924.13 KOO26606.1 - 2.6e-10 39.9 0.0 3.6e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Mechanosensitive ion channel Form_Nir_trans PF01226.12 KOO26606.1 - 0.036 12.9 0.6 0.06 12.2 0.4 1.3 1 0 0 1 1 1 0 Formate/nitrite transporter MIP PF00230.15 KOO26607.1 - 2.9e-43 147.9 23.0 5.5e-43 147.0 15.9 1.4 1 1 0 1 1 1 1 Major intrinsic protein rve PF00665.21 KOO26608.1 - 0.00013 22.0 0.1 0.00037 20.5 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain EF-hand_7 PF13499.1 KOO26610.1 - 1.4e-06 28.3 0.1 0.0024 17.9 0.0 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO26610.1 - 1.6e-06 27.5 0.2 0.079 12.8 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 KOO26610.1 - 5.3e-06 25.9 0.2 0.085 12.4 0.0 2.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO26610.1 - 0.00031 19.8 0.1 0.17 11.2 0.0 3.0 2 0 0 2 2 2 2 EF hand RPOL_N PF14700.1 KOO26610.1 - 0.11 11.7 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal EF-hand_5 PF13202.1 KOO26610.1 - 0.12 11.8 0.5 3.1 7.3 0.1 2.6 2 0 0 2 2 2 0 EF hand Exo_endo_phos PF03372.18 KOO26611.1 - 4.8e-10 39.8 0.9 4e-07 30.2 0.9 2.3 1 1 1 2 2 2 2 Endonuclease/Exonuclease/phosphatase family EF-hand_1 PF00036.27 KOO26611.1 - 1.3e-05 24.1 0.0 2.5e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO26611.1 - 5.3e-05 22.7 0.0 0.00013 21.5 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.1 KOO26611.1 - 0.00091 18.4 0.0 0.0023 17.2 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO26611.1 - 0.0068 16.5 0.0 0.014 15.5 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO26611.1 - 0.014 14.9 0.0 0.03 13.9 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair CLASP_N PF12348.3 KOO26614.1 - 1.8e-23 83.0 0.1 6.7e-17 61.6 0.0 2.8 3 0 0 3 3 3 2 CLASP N terminal COBRA1 PF06209.8 KOO26614.1 - 3.1e-10 39.2 0.0 0.00058 18.5 0.0 2.2 2 0 0 2 2 2 2 Cofactor of BRCA1 (COBRA1) DUF4042 PF13251.1 KOO26614.1 - 0.016 14.7 1.3 3.2 7.1 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4042) HEAT PF02985.17 KOO26614.1 - 0.23 11.6 7.7 17 5.7 0.0 5.8 5 0 0 5 5 5 0 HEAT repeat ThiF PF00899.16 KOO26615.1 - 6e-28 97.3 2.1 5.7e-27 94.1 0.0 2.4 3 0 0 3 3 3 1 ThiF family MoeZ_MoeB PF05237.8 KOO26615.1 - 0.0096 15.4 0.0 0.43 10.2 0.0 2.6 2 0 0 2 2 2 1 MoeZ/MoeB domain AAA_22 PF13401.1 KOO26615.1 - 0.091 12.9 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain NAD_binding_7 PF13241.1 KOO26615.1 - 0.11 12.7 0.0 0.3 11.3 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.14 KOO26615.1 - 0.12 11.4 0.6 0.29 10.2 0.1 1.8 2 1 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AMP-binding PF00501.23 KOO26616.1 - 9.5e-76 254.8 0.1 1.4e-75 254.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Dynein_heavy PF03028.10 KOO26617.1 - 2.5e-199 663.8 0.0 5e-199 662.8 0.0 1.5 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.8 KOO26617.1 - 7.1e-134 446.3 1.3 7.1e-134 446.3 0.9 2.2 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 KOO26617.1 - 2.8e-98 328.0 0.6 8.2e-98 326.5 0.1 2.0 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.2 KOO26617.1 - 3.7e-80 268.7 0.0 6.5e-80 267.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 MT PF12777.2 KOO26617.1 - 7.4e-58 195.9 15.1 1.3e-57 195.1 10.5 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_9 PF12781.2 KOO26617.1 - 5.7e-57 192.1 0.2 5.7e-57 192.1 0.2 2.3 3 0 0 3 3 3 1 ATP-binding dynein motor region D5 AAA_7 PF12775.2 KOO26617.1 - 2.8e-49 167.6 0.0 7.5e-49 166.2 0.0 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_5 PF07728.9 KOO26617.1 - 1.3e-09 37.8 0.0 0.067 12.9 0.0 5.7 4 1 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA PF00004.24 KOO26617.1 - 1e-06 29.0 0.8 0.15 12.2 0.0 4.9 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.1 KOO26617.1 - 3.2e-06 26.5 0.2 0.0039 16.6 0.0 3.6 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_16 PF13191.1 KOO26617.1 - 1.2e-05 25.3 0.3 0.39 10.6 0.0 5.3 4 1 1 5 5 5 1 AAA ATPase domain AAA_22 PF13401.1 KOO26617.1 - 2e-05 24.7 2.7 20 5.3 0.0 6.4 7 0 0 7 7 5 0 AAA domain AAA_18 PF13238.1 KOO26617.1 - 0.001 19.3 0.1 4.1 7.7 0.0 4.9 6 0 0 6 6 5 1 AAA domain DUF258 PF03193.11 KOO26617.1 - 0.0018 17.4 0.0 0.7 9.0 0.0 3.5 3 0 0 3 3 3 1 Protein of unknown function, DUF258 RNA_helicase PF00910.17 KOO26617.1 - 0.006 16.7 0.5 43 4.3 0.0 4.2 3 0 0 3 3 3 0 RNA helicase AAA_33 PF13671.1 KOO26617.1 - 0.0066 16.3 1.8 39 4.1 0.0 5.5 6 0 0 6 6 6 0 AAA domain AAA_25 PF13481.1 KOO26617.1 - 0.013 14.8 1.0 0.27 10.5 0.1 2.9 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 KOO26617.1 - 0.021 15.6 0.2 13 6.6 0.0 4.0 3 0 0 3 3 2 0 AAA domain TPR_11 PF13414.1 KOO26618.1 - 0.089 12.4 0.3 0.21 11.2 0.2 1.6 1 0 0 1 1 1 0 TPR repeat DUF374 PF04028.8 KOO26618.1 - 0.11 11.7 0.1 1.5 8.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF374) Ion_trans PF00520.26 KOO26619.1 - 0.0065 15.7 0.0 0.0092 15.2 0.0 1.2 1 0 0 1 1 1 1 Ion transport protein zf-H2C2_2 PF13465.1 KOO26620.1 - 6.8e-26 89.2 42.8 5.2e-08 32.8 1.3 7.2 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.21 KOO26620.1 - 3.2e-24 83.7 46.6 3e-05 24.1 1.4 6.4 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOO26620.1 - 3.2e-17 61.4 35.4 0.0014 18.7 0.7 6.6 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_6 PF13912.1 KOO26620.1 - 3.9e-06 26.5 28.3 0.0016 18.2 0.1 6.1 6 0 0 6 6 6 4 C2H2-type zinc finger zf-RING_2 PF13639.1 KOO26620.1 - 0.00037 20.2 0.8 0.00037 20.2 0.6 3.5 3 2 1 4 4 4 1 Ring finger domain FANCL_C PF11793.3 KOO26620.1 - 0.021 14.7 26.6 0.026 14.4 0.2 7.0 2 1 4 6 6 6 0 FANCL C-terminal domain zf-C2H2_jaz PF12171.3 KOO26620.1 - 0.47 10.6 28.1 1.7 8.9 0.9 6.0 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding CHORD PF04968.7 KOO26620.1 - 0.67 10.2 27.8 2.7 8.3 0.5 5.5 2 1 3 5 5 5 0 CHORD Fer2 PF00111.22 KOO26620.1 - 4.7 7.0 15.2 31 4.3 0.1 5.3 5 0 0 5 5 5 0 2Fe-2S iron-sulfur cluster binding domain Ion_trans PF00520.26 KOO26621.1 - 3e-17 62.5 1.4 5.7e-17 61.6 0.9 1.4 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO26621.1 - 8.9e-12 44.5 0.4 8.9e-12 44.5 0.3 2.0 2 0 0 2 2 2 1 Ion channel EF-hand_5 PF13202.1 KOO26621.1 - 1.1e-05 24.5 2.1 0.00025 20.2 0.1 3.1 3 0 0 3 3 3 1 EF hand EF-hand_1 PF00036.27 KOO26621.1 - 1.7e-05 23.7 0.2 0.0045 16.2 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO26621.1 - 2e-05 24.0 0.5 0.21 11.5 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO26621.1 - 2.9e-05 24.0 3.9 0.00049 20.1 0.6 2.6 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO26621.1 - 0.016 14.7 0.3 0.062 12.9 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain pair Aminotran_1_2 PF00155.16 KOO26622.1 - 1.1e-42 146.3 0.0 1.2e-42 146.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 KOO26622.1 - 4e-07 28.6 0.0 5.3e-07 28.2 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.16 KOO26622.1 - 0.00086 18.5 0.0 0.0015 17.7 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.14 KOO26622.1 - 0.012 14.4 0.0 0.024 13.3 0.0 1.4 2 0 0 2 2 2 0 Aminotransferase class-V Ank_2 PF12796.2 KOO26623.1 - 1.2e-14 54.4 0.4 8.3e-09 35.6 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO26623.1 - 4.7e-13 47.9 0.0 0.0035 17.4 0.0 3.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 KOO26623.1 - 2.8e-10 40.1 0.2 5.9e-06 26.3 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO26623.1 - 3e-10 39.3 0.1 0.00054 19.6 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 KOO26623.1 - 3.7e-10 40.0 0.0 0.00021 21.6 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Abhydrolase_6 PF12697.2 KOO26624.1 - 4e-07 30.1 2.0 5.8e-07 29.6 1.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO26624.1 - 0.091 12.5 0.0 0.11 12.3 0.0 1.3 1 1 0 1 1 1 0 Alpha/beta hydrolase family UBA PF00627.26 KOO26625.1 - 0.00016 21.4 1.8 0.00033 20.4 1.2 1.6 1 0 0 1 1 1 1 UBA/TS-N domain DUF3577 PF12101.3 KOO26625.1 - 0.11 12.3 0.1 0.67 9.8 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3577) Glyoxalase_3 PF13468.1 KOO26626.1 - 2e-29 102.7 0.1 2.6e-29 102.3 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.1 KOO26626.1 - 0.14 12.2 0.1 3.4 7.7 0.0 2.5 2 1 0 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Peptidase_M10 PF00413.19 KOO26627.1 - 1.2e-22 80.2 0.0 1.7e-22 79.8 0.0 1.1 1 0 0 1 1 1 1 Matrixin PG_binding_1 PF01471.13 KOO26627.1 - 3.7e-09 36.4 0.0 9.1e-09 35.1 0.0 1.7 1 0 0 1 1 1 1 Putative peptidoglycan binding domain PG_binding_3 PF09374.5 KOO26627.1 - 5.1e-06 26.3 1.9 0.026 14.5 0.0 2.7 2 1 1 3 3 3 2 Predicted Peptidoglycan domain Metallopep PF12044.3 KOO26627.1 - 0.022 13.2 0.0 0.031 12.7 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family cNMP_binding PF00027.24 KOO26628.1 - 2.8e-15 55.8 0.0 6.9e-15 54.6 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain C2 PF00168.25 KOO26629.1 - 6.6e-05 22.6 0.0 0.00011 21.9 0.0 1.4 1 0 0 1 1 1 1 C2 domain PX PF00787.19 KOO26629.1 - 0.00027 20.6 0.1 0.00048 19.9 0.1 1.4 1 0 0 1 1 1 1 PX domain Methyltransf_22 PF13383.1 KOO26630.1 - 1.2e-25 90.5 0.1 1.3e-25 90.3 0.0 1.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_21 PF05050.7 KOO26630.1 - 0.0012 18.8 0.0 0.0013 18.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain PABP PF00658.13 KOO26631.1 - 5.8e-08 32.2 0.0 2e-07 30.5 0.0 1.9 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain OTU PF02338.14 KOO26631.1 - 0.00013 22.5 0.5 0.00025 21.6 0.0 1.8 2 0 0 2 2 2 1 OTU-like cysteine protease KAT11 PF08214.6 KOO26632.1 - 8e-28 97.5 0.1 1.6e-27 96.4 0.0 1.5 1 1 0 1 1 1 1 Histone acetylation protein VIT1 PF01988.14 KOO26633.1 - 1.6e-21 76.7 21.7 1.5e-13 50.7 2.4 2.8 2 1 1 3 3 3 2 VIT family TPT PF03151.11 KOO26633.1 - 7.2e-05 22.4 2.9 8e-05 22.3 0.2 2.4 2 0 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 KOO26633.1 - 0.00018 20.5 1.4 0.00036 19.5 0.2 2.0 2 0 0 2 2 2 1 UAA transporter family EamA PF00892.15 KOO26633.1 - 0.0039 17.2 7.9 0.0039 17.2 5.5 3.6 3 2 0 3 3 3 1 EamA-like transporter family Kinesin PF00225.18 KOO26634.1 - 2.3e-64 217.2 0.0 6.4e-43 146.7 0.0 2.2 2 0 0 2 2 2 2 Kinesin motor domain SAP PF02037.22 KOO26634.1 - 6.5e-05 22.3 1.0 0.0001 21.7 0.0 1.9 2 0 0 2 2 2 1 SAP domain RRM_6 PF14259.1 KOO26634.1 - 0.00062 19.7 0.0 0.0038 17.1 0.0 2.3 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) XRCC4 PF06632.7 KOO26636.1 - 0.00095 18.1 1.9 0.0036 16.2 1.3 1.9 1 1 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 Uso1_p115_C PF04871.8 KOO26636.1 - 0.0056 16.6 2.9 0.0091 15.9 2.0 1.3 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, C terminal region Sporozoite_P67 PF05642.6 KOO26636.1 - 0.15 9.8 2.1 0.22 9.3 1.5 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SH3_2 PF07653.12 KOO26638.1 - 5.2e-12 45.0 0.0 1.1e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 KOO26638.1 - 4.6e-10 38.9 0.0 1e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 KOO26638.1 - 1.4e-08 33.9 0.1 2.8e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain MORN PF02493.15 KOO26638.1 - 0.36 10.6 7.6 0.68 9.7 0.3 4.1 3 0 0 3 3 3 0 MORN repeat CBM_20 PF00686.14 KOO26639.1 - 1.1e-12 47.4 0.0 1.3e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 Starch binding domain AMP-binding PF00501.23 KOO26640.1 - 8.4e-62 208.8 1.0 3.1e-59 200.4 0.7 2.5 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 KOO26640.1 - 0.0024 18.7 0.1 0.0057 17.5 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain PhyH PF05721.8 KOO26641.1 - 5e-12 46.3 0.0 6.6e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) RRM_1 PF00076.17 KOO26641.1 - 0.00014 21.4 0.0 0.013 15.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO26641.1 - 0.0091 15.9 0.0 0.54 10.2 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Kinesin PF00225.18 KOO26642.1 - 2.2e-109 365.2 0.1 1.1e-100 336.6 0.0 2.2 2 0 0 2 2 2 2 Kinesin motor domain IncA PF04156.9 KOO26642.1 - 0.013 15.0 1.2 0.022 14.3 0.8 1.3 1 0 0 1 1 1 0 IncA protein P53 PF00870.13 KOO26642.1 - 0.044 13.3 0.0 0.079 12.5 0.0 1.3 1 0 0 1 1 1 0 P53 DNA-binding domain ResIII PF04851.10 KOO26642.1 - 0.059 13.1 1.3 0.87 9.3 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit HsbA PF12296.3 KOO26642.1 - 0.073 12.9 0.6 0.21 11.4 0.4 1.7 1 0 0 1 1 1 0 Hydrophobic surface binding protein A Ank PF00023.25 KOO26643.1 - 7.1e-19 66.6 14.0 3.7e-07 29.6 0.0 6.3 6 0 0 6 6 6 4 Ankyrin repeat Ank_2 PF12796.2 KOO26643.1 - 6.8e-18 64.8 0.4 5.3e-07 29.9 0.2 4.4 4 1 1 5 5 5 4 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO26643.1 - 3.5e-14 51.4 3.4 3.5e-05 23.6 0.0 5.3 6 0 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.1 KOO26643.1 - 6.9e-12 45.2 6.1 2.9e-05 24.1 0.1 4.6 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO26643.1 - 1.8e-07 31.4 3.1 0.0039 17.6 0.0 4.9 6 0 0 6 6 6 2 Ankyrin repeats (many copies) ADK PF00406.17 KOO26644.1 - 0.14 12.0 1.8 0.17 11.7 1.0 1.4 1 1 0 1 1 1 0 Adenylate kinase SDH_alpha PF03313.10 KOO26644.1 - 0.18 10.7 10.4 0.054 12.5 4.9 1.8 1 1 2 3 3 3 0 Serine dehydratase alpha chain Ly49 PF08391.5 KOO26644.1 - 0.27 11.3 0.2 0.27 11.3 0.1 2.6 1 1 1 3 3 3 0 Ly49-like protein, N-terminal region ApoLp-III PF07464.6 KOO26644.1 - 6.5 6.7 14.3 0.081 12.9 3.3 2.4 2 2 1 3 3 3 0 Apolipophorin-III precursor (apoLp-III) PAN_4 PF14295.1 KOO26645.1 - 0.011 15.4 1.4 0.02 14.6 1.0 1.4 1 0 0 1 1 1 0 PAN domain PAN_2 PF08276.6 KOO26645.1 - 0.011 15.5 2.1 0.028 14.2 1.0 2.1 3 0 0 3 3 3 0 PAN-like domain RRM_1 PF00076.17 KOO26647.1 - 1.3e-31 108.0 0.5 1.7e-16 59.6 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO26647.1 - 5.4e-27 93.5 0.1 4.9e-13 48.8 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO26647.1 - 3.9e-21 74.6 0.1 2.4e-09 36.9 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 KOO26647.1 - 4.9e-08 32.6 0.1 0.0017 18.0 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 KOO26647.1 - 1.2e-05 25.1 0.4 0.0048 16.7 0.1 2.1 2 0 0 2 2 2 2 RNA binding motif Limkain-b1 PF11608.3 KOO26647.1 - 0.0086 15.8 0.0 1.8 8.3 0.0 2.3 2 0 0 2 2 2 2 Limkain b1 DUF1866 PF08952.6 KOO26647.1 - 0.011 15.2 0.0 0.47 9.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1866) RNA_bind PF08675.6 KOO26647.1 - 0.091 12.7 0.1 0.33 10.9 0.0 1.8 2 0 0 2 2 2 0 RNA binding domain RB_A PF01858.12 KOO26648.1 - 4.5e-44 150.4 0.0 8.5e-44 149.5 0.0 1.5 1 0 0 1 1 1 1 Retinoblastoma-associated protein A domain RB_B PF01857.15 KOO26648.1 - 9.1e-31 106.1 0.7 1.6e-30 105.4 0.5 1.4 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain TPR_12 PF13424.1 KOO26650.1 - 8.8e-26 89.6 25.6 3.1e-11 43.0 1.1 3.4 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.1 KOO26650.1 - 3.1e-15 55.5 26.3 7.9e-06 25.6 0.4 5.5 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_11 PF13414.1 KOO26650.1 - 1e-06 28.2 10.2 0.004 16.7 0.9 3.4 3 0 0 3 3 3 2 TPR repeat Apc3 PF12895.2 KOO26650.1 - 9e-06 25.7 3.1 0.00045 20.2 0.2 3.0 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 KOO26650.1 - 2.2e-05 24.0 17.5 0.047 13.6 1.4 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO26650.1 - 0.0001 21.7 13.4 0.058 13.0 0.8 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO26650.1 - 0.0018 18.8 28.3 0.036 14.7 3.4 4.7 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO26650.1 - 0.0026 17.4 15.0 1.4 8.9 0.1 5.1 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO26650.1 - 0.0048 16.5 5.3 0.2 11.5 0.1 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat Flu_M1_C PF08289.6 KOO26650.1 - 0.14 12.2 0.8 0.64 10.0 0.0 2.4 2 0 0 2 2 2 0 Influenza Matrix protein (M1) C-terminal domain TPR_19 PF14559.1 KOO26650.1 - 4.8 7.6 14.4 4.6 7.6 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat EF-hand_1 PF00036.27 KOO26651.1 - 5.1e-20 69.1 3.1 8.2e-06 24.7 0.0 4.5 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 KOO26651.1 - 9.9e-18 62.3 2.5 0.00013 21.5 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO26651.1 - 4.9e-15 55.4 1.6 1e-08 35.1 0.3 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO26651.1 - 3.6e-13 48.1 1.8 0.003 16.8 0.0 3.8 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 KOO26651.1 - 2.5e-12 46.2 0.7 0.0014 18.1 0.0 3.6 3 0 0 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO26651.1 - 0.003 17.5 0.9 0.42 10.6 0.0 3.6 3 1 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO26651.1 - 0.3 10.7 1.2 15 5.3 0.0 2.9 3 0 0 3 3 3 0 EF hand LRR_4 PF12799.2 KOO26652.1 - 2.7e-18 65.1 1.6 1.3e-08 34.3 0.1 3.6 3 1 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO26652.1 - 2.8e-11 43.0 6.1 1.6e-06 27.7 0.6 3.9 1 1 3 4 4 4 4 Leucine rich repeat LRR_6 PF13516.1 KOO26652.1 - 2.7e-07 29.9 1.5 1.1 9.5 0.0 5.6 6 0 0 6 6 6 2 Leucine Rich repeat LRR_1 PF00560.28 KOO26652.1 - 3.2e-07 29.4 3.7 2.4 8.5 0.0 5.8 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_9 PF14580.1 KOO26652.1 - 6.8e-07 28.9 0.3 0.003 17.1 0.0 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_7 PF13504.1 KOO26652.1 - 9.5e-07 28.0 3.0 1.5 9.3 0.0 5.7 5 0 0 5 5 5 2 Leucine rich repeat F-box-like PF12937.2 KOO26653.1 - 0.042 13.5 0.4 0.13 12.0 0.1 1.9 2 0 0 2 2 2 0 F-box-like PPR_2 PF13041.1 KOO26654.1 - 0.0055 16.6 0.0 3.3 7.7 0.0 2.5 2 0 0 2 2 2 2 PPR repeat family ECH PF00378.15 KOO26654.1 - 0.043 12.9 0.5 0.075 12.1 0.4 1.4 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase family PPR_3 PF13812.1 KOO26654.1 - 0.099 12.9 4.8 2.7 8.5 0.0 4.6 5 0 0 5 5 5 0 Pentatricopeptide repeat domain SRP72 PF08492.7 KOO26655.1 - 0.0096 16.2 1.3 0.0096 16.2 0.9 1.8 2 0 0 2 2 2 1 SRP72 RNA-binding domain Arm PF00514.18 KOO26656.1 - 0.13 12.1 5.8 6.4 6.7 0.0 4.8 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Kinesin-relat_1 PF12711.2 KOO26659.1 - 0.13 12.6 1.8 0.68 10.3 0.3 2.1 1 1 1 2 2 2 0 Kinesin motor MT-A70 PF05063.9 KOO26660.1 - 6.6e-46 156.0 0.0 1e-45 155.4 0.0 1.3 1 0 0 1 1 1 1 MT-A70 Methyltransf_21 PF05050.7 KOO26660.1 - 1.3e-08 34.9 0.0 4.2e-08 33.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_22 PF13383.1 KOO26660.1 - 0.093 12.2 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_21 PF05050.7 KOO26662.1 - 4.5e-10 39.7 0.0 1.1e-09 38.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase FkbM domain EF-hand_7 PF13499.1 KOO26664.1 - 2.2e-44 149.4 1.3 1.5e-08 34.6 0.0 5.6 4 1 1 5 5 5 5 EF-hand domain pair EF-hand_6 PF13405.1 KOO26664.1 - 5.9e-43 140.8 9.5 2.3e-05 23.9 0.1 9.3 8 1 1 9 9 9 9 EF-hand domain EF-hand_1 PF00036.27 KOO26664.1 - 7.3e-43 140.6 6.3 2.8e-06 26.2 0.2 9.2 8 1 1 9 9 9 8 EF hand EF-hand_5 PF13202.1 KOO26664.1 - 1.8e-34 115.5 7.7 6.1e-05 22.1 0.1 9.2 8 1 1 9 9 9 7 EF hand EF-hand_8 PF13833.1 KOO26664.1 - 2.1e-23 81.7 9.7 1e-05 25.0 0.8 8.7 4 3 5 9 9 9 7 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO26664.1 - 7.5e-09 35.6 0.0 1.6 8.8 0.0 5.4 4 2 2 6 6 6 4 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOO26664.1 - 6e-08 32.4 0.0 3.1 7.7 0.0 5.7 5 0 0 5 5 5 3 EF-hand domain Peptidase_M10_C PF08548.6 KOO26664.1 - 0.027 14.0 0.1 13 5.2 0.0 4.1 4 1 1 5 5 5 0 Peptidase M10 serralysin C terminal SAP PF02037.22 KOO26664.1 - 0.043 13.3 1.8 9.4 5.8 0.0 2.9 3 0 0 3 3 3 0 SAP domain TPMT PF05724.6 KOO26665.1 - 1.7e-34 119.2 0.0 2.3e-34 118.7 0.0 1.1 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_11 PF08241.7 KOO26665.1 - 3e-09 37.2 0.0 4.9e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO26665.1 - 7.8e-08 32.0 0.0 9.8e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO26665.1 - 9.6e-08 32.0 0.1 1.5e-07 31.4 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO26665.1 - 2.2e-07 31.4 0.1 4.2e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO26665.1 - 5.6e-07 29.9 0.0 9.5e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO26665.1 - 9.1e-06 25.4 0.0 1.4e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 KOO26665.1 - 0.022 13.8 0.0 0.031 13.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) 2OG-FeII_Oxy_3 PF13640.1 KOO26667.1 - 4.8e-14 52.6 0.0 8.6e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO26667.1 - 0.00061 20.0 0.0 0.0013 18.9 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily FtsK_SpoIIIE PF01580.13 KOO26668.1 - 0.09 12.2 0.9 0.15 11.5 0.6 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family JmjC PF02373.17 KOO26669.1 - 1.8e-31 108.6 0.0 2.9e-31 108.0 0.0 1.3 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.12 KOO26669.1 - 9.4e-11 41.0 0.1 1.6e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 jmjN domain Astro_capsid PF03115.9 KOO26670.1 - 0.21 9.8 0.0 0.28 9.3 0.0 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor Myb_DNA-binding PF00249.26 KOO26672.1 - 9e-29 99.2 4.0 5.6e-14 51.9 0.1 2.6 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO26672.1 - 1.2e-20 73.3 0.5 2.1e-11 43.7 0.0 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain EF-hand_7 PF13499.1 KOO26672.1 - 1.8e-13 50.4 0.1 8.4e-13 48.2 0.2 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO26672.1 - 1.1e-11 43.1 0.8 9.7e-05 21.4 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO26672.1 - 8.1e-11 41.3 1.9 3.4e-07 29.7 0.4 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO26672.1 - 1.4e-08 33.8 0.2 7.6e-05 22.2 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO26672.1 - 1.5e-08 33.6 3.1 0.00066 18.9 0.0 2.8 3 0 0 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.4 KOO26672.1 - 0.11 12.4 0.0 0.36 10.8 0.0 1.8 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Adenine_glyco PF03352.8 KOO26672.1 - 0.14 11.6 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 Methyladenine glycosylase EF-hand_1 PF00036.27 KOO26674.1 - 1.4e-36 120.9 17.9 4.2e-06 25.6 0.1 6.2 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.1 KOO26674.1 - 2.6e-31 104.6 21.3 2.2e-05 23.9 0.1 6.3 6 0 0 6 6 6 6 EF-hand domain EF-hand_7 PF13499.1 KOO26674.1 - 1e-28 99.2 25.1 1.2e-10 41.3 2.3 4.3 2 2 3 5 5 5 5 EF-hand domain pair EF-hand_8 PF13833.1 KOO26674.1 - 2e-27 94.5 19.8 6.8e-09 35.2 0.7 5.7 3 3 3 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.1 KOO26674.1 - 4.2e-27 92.2 18.8 0.00012 21.2 0.1 6.3 6 0 0 6 6 6 6 EF hand SPARC_Ca_bdg PF10591.4 KOO26674.1 - 0.0018 18.3 2.1 9.8 6.2 0.0 4.0 2 1 2 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO26674.1 - 0.023 14.4 9.7 0.43 10.3 0.1 4.6 4 2 2 6 6 6 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO26674.1 - 0.23 11.1 6.2 5 6.8 0.2 4.5 6 0 0 6 6 6 0 EF hand AP2 PF00847.15 KOO26675.1 - 3.4e-08 33.5 5.9 0.00021 21.3 1.3 3.7 4 2 0 4 4 4 2 AP2 domain HlyU PF10115.4 KOO26675.1 - 0.064 13.1 0.1 0.64 9.9 0.0 2.1 2 0 0 2 2 2 0 Transcriptional activator HlyU Pro_isomerase PF00160.16 KOO26676.1 - 2e-35 122.2 0.1 2.6e-35 121.9 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD OEP PF02321.13 KOO26678.1 - 0.001 18.7 6.8 0.001 18.7 4.7 3.3 3 1 0 3 3 3 1 Outer membrane efflux protein Phage_GP20 PF06810.6 KOO26678.1 - 0.058 12.8 13.4 0.092 12.1 1.8 2.9 3 1 0 3 3 3 0 Phage minor structural protein GP20 Reo_sigmaC PF04582.7 KOO26678.1 - 0.33 10.0 10.1 2.2 7.4 1.8 2.1 2 0 0 2 2 2 0 Reovirus sigma C capsid protein DUF641 PF04859.7 KOO26678.1 - 0.61 9.8 21.4 0.26 11.0 3.6 3.1 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) rRNA_processing PF08524.6 KOO26678.1 - 0.83 9.4 4.6 15 5.3 0.0 2.3 2 1 0 2 2 2 0 rRNA processing DUF342 PF03961.8 KOO26678.1 - 1.3 7.3 6.6 2.7 6.3 1.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF342) IFT57 PF10498.4 KOO26678.1 - 2.4 6.8 12.6 1.5 7.4 1.8 2.1 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 ADIP PF11559.3 KOO26678.1 - 3 7.7 25.2 0.049 13.5 5.2 2.8 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding AAA_13 PF13166.1 KOO26678.1 - 4.6 5.5 11.6 4.6 5.5 2.0 2.0 2 0 0 2 2 2 0 AAA domain Lge1 PF11488.3 KOO26678.1 - 7.3 6.8 8.1 3.4 7.9 0.1 3.3 2 1 0 3 3 3 0 Transcriptional regulatory protein LGE1 HopJ PF08888.6 KOO26679.1 - 5.9e-36 122.8 0.0 6.9e-36 122.6 0.0 1.0 1 0 0 1 1 1 1 HopJ type III effector protein Metallophos PF00149.23 KOO26680.1 - 4.9e-10 39.1 0.0 3.6e-09 36.3 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KOO26680.1 - 2.3e-06 27.5 0.0 5.8e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PhoD PF09423.5 KOO26680.1 - 0.047 12.2 0.2 0.64 8.5 0.1 2.2 1 1 0 1 1 1 0 PhoD-like phosphatase TPR_2 PF07719.12 KOO26682.1 - 9.9e-05 21.9 2.1 0.15 12.0 0.1 4.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO26682.1 - 0.003 17.0 0.0 1.4 8.6 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO26682.1 - 0.0038 16.8 14.4 0.59 9.8 0.0 4.0 3 1 1 4 4 4 3 TPR repeat TPR_16 PF13432.1 KOO26682.1 - 0.0067 17.0 1.9 0.0067 17.0 1.3 6.0 4 1 3 7 7 7 2 Tetratricopeptide repeat TPR_20 PF14561.1 KOO26682.1 - 0.0094 16.0 0.9 0.0094 16.0 0.6 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO26682.1 - 0.025 15.1 3.4 0.025 15.1 2.4 5.4 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO26682.1 - 0.045 14.2 0.5 0.045 14.2 0.3 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Peptidase_C1 PF00112.18 KOO26683.1 - 4.4e-13 49.6 0.0 2.6e-10 40.5 0.0 2.9 1 1 0 1 1 1 1 Papain family cysteine protease Glycos_transf_2 PF00535.21 KOO26685.1 - 0.001 18.7 0.0 0.0018 17.9 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_64 PF09258.5 KOO26685.1 - 0.0015 17.7 0.0 0.0019 17.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Chloroa_b-bind PF00504.16 KOO26686.1 - 6.4e-30 104.4 0.1 8.7e-30 104.0 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein DUF3110 PF11360.3 KOO26687.1 - 3e-14 52.5 0.2 4.9e-11 42.3 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3110) SUKH_6 PF14568.1 KOO26687.1 - 0.14 12.6 0.0 0.34 11.3 0.0 1.7 2 0 0 2 2 2 0 SMI1-KNR4 cell-wall PUB PF09409.5 KOO26688.1 - 6.1e-14 51.5 0.0 9.4e-14 50.9 0.0 1.3 1 0 0 1 1 1 1 PUB domain Synaphin PF05835.7 KOO26688.1 - 0.0012 18.9 1.2 0.0025 17.9 0.8 1.5 1 0 0 1 1 1 1 Synaphin protein ESX-1_EspG PF14011.1 KOO26688.1 - 0.0078 15.4 2.2 0.0095 15.2 1.5 1.1 1 0 0 1 1 1 1 EspG family ABA_WDS PF02496.11 KOO26688.1 - 0.34 11.0 3.6 0.26 11.5 0.5 2.4 2 2 2 4 4 4 0 ABA/WDS induced protein DUF3154 PF11351.3 KOO26688.1 - 0.35 10.6 2.7 10 5.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3154) LRR_6 PF13516.1 KOO26689.1 - 3.7e-25 85.1 0.3 0.00031 20.4 0.0 6.4 6 0 0 6 6 6 5 Leucine Rich repeat LRR_1 PF00560.28 KOO26689.1 - 2.8e-05 23.5 0.0 20 5.7 0.0 6.1 6 1 0 6 6 6 1 Leucine Rich Repeat LRR_4 PF12799.2 KOO26689.1 - 5.3e-05 22.7 2.3 0.27 10.8 0.0 4.6 3 2 0 4 4 4 1 Leucine Rich repeats (2 copies) SpoU_sub_bind PF08032.7 KOO26689.1 - 9.7e-05 22.4 0.9 0.5 10.5 0.0 2.9 3 0 0 3 3 3 2 RNA 2'-O ribose methyltransferase substrate binding LRR_7 PF13504.1 KOO26689.1 - 0.004 17.1 7.0 18 6.0 0.0 6.0 7 0 0 7 7 7 1 Leucine rich repeat Phage_integ_N PF09003.5 KOO26689.1 - 0.038 13.6 5.5 0.28 10.8 0.0 3.7 4 0 0 4 4 4 0 Bacteriophage lambda integrase, N-terminal domain CbiG_N PF11760.3 KOO26689.1 - 0.044 13.4 4.7 26 4.6 0.0 4.1 4 0 0 4 4 4 0 Cobalamin synthesis G N-terminal PurS PF02700.9 KOO26690.1 - 0.038 13.9 0.0 0.15 11.9 0.0 2.0 2 0 0 2 2 2 0 Phosphoribosylformylglycinamidine (FGAM) synthase Cys_Met_Meta_PP PF01053.15 KOO26691.1 - 5.3e-65 219.1 0.0 4.1e-48 163.5 0.0 2.5 2 1 0 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme WD40 PF00400.27 KOO26693.1 - 1.2e-31 107.4 11.2 3.6e-06 26.6 0.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat LRR_1 PF00560.28 KOO26693.1 - 0.15 12.1 0.3 57 4.3 0.4 4.1 4 1 0 4 4 4 0 Leucine Rich Repeat LRR_4 PF12799.2 KOO26693.1 - 0.17 11.5 0.6 11 5.7 0.0 3.0 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO26693.1 - 0.76 10.2 5.4 72 4.2 0.2 5.2 6 0 0 6 6 6 0 Leucine rich repeat EF-hand_1 PF00036.27 KOO26694.1 - 2.2e-09 35.9 1.1 2.4e-05 23.3 0.0 3.8 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.1 KOO26694.1 - 2.7e-08 33.0 0.1 1.7e-05 24.2 0.0 3.8 5 0 0 5 5 5 1 EF-hand domain EF-hand_8 PF13833.1 KOO26694.1 - 4.1e-08 32.7 1.2 0.038 13.6 0.1 4.2 4 1 1 5 5 5 3 EF-hand domain pair EF-hand_7 PF13499.1 KOO26694.1 - 2.7e-07 30.6 0.0 4.8e-05 23.4 0.0 2.6 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO26694.1 - 1.7e-06 27.1 0.1 0.00094 18.4 0.1 2.6 2 0 0 2 2 2 2 EF hand PMBR PF09373.5 KOO26694.1 - 0.14 12.1 0.0 19 5.4 0.0 2.8 3 0 0 3 3 3 0 Pseudomurein-binding repeat AAA_13 PF13166.1 KOO26695.1 - 0.038 12.4 2.7 0.044 12.2 1.9 1.0 1 0 0 1 1 1 0 AAA domain DUF1795 PF08786.6 KOO26695.1 - 0.061 13.1 0.4 0.11 12.3 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1795) DUF3450 PF11932.3 KOO26695.1 - 0.18 11.0 12.8 0.27 10.4 8.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Fez1 PF06818.10 KOO26695.1 - 0.27 11.2 17.0 0.44 10.5 11.7 1.3 1 0 0 1 1 1 0 Fez1 Tropomyosin PF00261.15 KOO26695.1 - 0.59 9.1 20.0 0.85 8.6 1.3 2.2 1 1 1 2 2 2 0 Tropomyosin YlqD PF11068.3 KOO26695.1 - 0.89 9.5 6.6 1.4 8.9 4.6 1.4 1 0 0 1 1 1 0 YlqD protein DUF3584 PF12128.3 KOO26695.1 - 1.1 6.4 19.3 1.4 6.1 13.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Nup54 PF13874.1 KOO26695.1 - 1.3 8.6 13.6 0.51 10.0 4.9 2.1 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 DUF972 PF06156.8 KOO26695.1 - 3.9 7.8 6.6 6.6 7.1 3.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Atg14 PF10186.4 KOO26695.1 - 5 5.9 8.2 6.3 5.6 5.7 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 TFIIA PF03153.8 KOO26695.1 - 6.4 6.5 7.0 8 6.2 4.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit APG6 PF04111.7 KOO26695.1 - 7.2 5.5 11.8 4.7 6.1 6.2 1.4 1 1 1 2 2 2 0 Autophagy protein Apg6 OmpH PF03938.9 KOO26695.1 - 7.4 6.4 17.0 11 5.9 11.8 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) ATC_hydrolase PF14196.1 KOO26695.1 - 9.1 6.6 12.6 3 8.2 3.3 2.2 1 1 1 2 2 2 0 L-2-amino-thiazoline-4-carboxylic acid hydrolase DnaJ PF00226.26 KOO26697.1 - 1.2e-19 69.8 0.2 1.9e-19 69.1 0.2 1.3 1 0 0 1 1 1 1 DnaJ domain Pentapeptide_4 PF13599.1 KOO26698.1 - 1.9e-55 184.6 0.0 1.3e-06 28.1 0.0 13.7 6 5 8 15 15 15 13 Pentapeptide repeats (9 copies) EF-hand_1 PF00036.27 KOO26698.1 - 1.1e-10 40.0 0.3 0.00018 20.5 0.0 3.2 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO26698.1 - 7.9e-10 38.7 0.4 7.9e-10 38.7 0.3 2.5 3 0 0 3 3 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO26698.1 - 2.4e-09 36.2 0.5 5.5e-05 22.7 0.0 4.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO26698.1 - 3.8e-08 32.2 0.6 0.0015 17.7 0.0 3.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO26698.1 - 8.8e-07 28.4 1.2 5.3e-05 22.7 0.0 4.0 3 0 0 3 3 3 1 EF-hand domain pair XK-related PF09815.4 KOO26698.1 - 0.00061 18.9 7.6 0.0017 17.4 5.3 1.6 1 1 0 1 1 1 1 XK-related protein Toxin_54 PF15533.1 KOO26698.1 - 0.0049 17.0 1.1 24 5.2 0.0 6.4 5 1 0 5 5 4 0 Putative toxin 54 Ribosomal_L13e PF01294.13 KOO26698.1 - 0.015 14.7 17.3 0.5 9.8 0.0 9.2 10 4 4 15 15 15 0 Ribosomal protein L13e T2SM PF04612.7 KOO26698.1 - 2 8.1 9.7 1.4 8.6 0.0 3.5 4 0 0 4 4 4 0 Type II secretion system (T2SS), protein M Mnd1 PF03962.10 KOO26698.1 - 4.1 7.0 5.8 1 9.0 1.3 1.8 2 0 0 2 2 2 0 Mnd1 family EF-hand_6 PF13405.1 KOO26699.1 - 3.7e-13 48.1 2.7 0.0043 16.8 0.0 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.27 KOO26699.1 - 5e-13 47.3 5.7 0.0029 16.7 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.1 KOO26699.1 - 1.3e-09 38.0 3.4 1e-05 25.5 0.3 3.3 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO26699.1 - 1.2e-07 30.6 6.5 0.18 11.2 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 KOO26699.1 - 5.7e-07 29.0 3.4 0.028 14.0 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.2 KOO26699.1 - 0.022 14.5 2.3 1.9 8.2 0.1 3.0 3 0 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand DSPn PF14671.1 KOO26699.1 - 0.11 12.4 0.0 0.27 11.1 0.0 1.6 1 1 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half Helicase_C PF00271.26 KOO26700.1 - 1.1e-12 47.5 0.5 1.4e-12 47.3 0.3 1.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Podovirus_Gp16 PF05894.7 KOO26701.1 - 0.18 11.0 0.0 0.26 10.5 0.0 1.1 1 0 0 1 1 1 0 Podovirus DNA encapsidation protein (Gp16) HA2 PF04408.18 KOO26702.1 - 8.7e-07 28.9 0.0 1.8e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) AAA_27 PF13514.1 KOO26703.1 - 0.00056 17.7 1.1 0.00058 17.7 0.8 1.0 1 0 0 1 1 1 1 AAA domain DMPK_coil PF08826.5 KOO26703.1 - 0.083 12.8 0.4 0.083 12.8 0.3 1.8 2 1 0 2 2 2 0 DMPK coiled coil domain like GAS PF13851.1 KOO26703.1 - 0.15 11.2 1.5 0.21 10.7 1.1 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding vMSA PF00695.14 KOO26703.1 - 0.33 10.1 1.2 0.33 10.1 0.9 1.1 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus TPR_11 PF13414.1 KOO26704.1 - 2.6e-19 68.6 4.8 1.5e-15 56.5 1.1 2.4 2 1 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 KOO26704.1 - 6.4e-16 57.2 3.3 1.1e-06 27.9 0.2 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO26704.1 - 5.5e-10 38.3 5.5 0.0007 19.3 0.1 3.6 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO26704.1 - 9.2e-07 28.2 0.4 0.023 14.4 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO26704.1 - 1.2e-05 25.5 0.3 0.15 12.7 0.1 2.8 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO26704.1 - 0.00016 21.5 3.3 0.0012 18.7 0.3 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 KOO26704.1 - 0.00041 20.4 2.1 0.00065 19.7 1.5 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 KOO26704.1 - 0.0013 18.3 1.4 4.7 7.2 0.1 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.1 KOO26704.1 - 0.006 15.6 0.0 0.0086 15.1 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOO26704.1 - 0.017 14.9 0.2 0.062 13.1 0.0 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.1 KOO26704.1 - 0.018 15.7 6.6 0.14 12.8 0.7 2.9 2 2 1 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.1 KOO26704.1 - 0.019 15.1 0.7 1.6 9.1 0.0 3.3 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_3 PF07720.7 KOO26704.1 - 0.034 13.9 0.3 0.097 12.4 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.9 KOO26704.1 - 0.035 14.5 1.6 0.15 12.5 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat RPN7 PF10602.4 KOO26704.1 - 0.04 13.3 0.8 0.38 10.1 0.1 2.1 2 0 0 2 2 2 0 26S proteasome subunit RPN7 TPR_6 PF13174.1 KOO26704.1 - 0.045 14.2 1.3 3.3 8.3 0.0 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 KOO26704.1 - 0.12 12.6 1.6 2.2 8.6 0.2 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat MAS20 PF02064.10 KOO26704.1 - 0.13 12.1 0.0 6.7 6.6 0.0 2.2 1 1 1 2 2 2 0 MAS20 protein import receptor MIT PF04212.13 KOO26704.1 - 0.34 10.8 1.9 2 8.3 0.5 2.3 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_10 PF13374.1 KOO26704.1 - 0.82 9.6 2.8 2.6 8.1 0.0 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Pkinase PF00069.20 KOO26705.1 - 1.9e-43 148.4 0.0 2.6e-43 148.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO26705.1 - 2e-19 69.6 0.0 2.8e-19 69.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO26705.1 - 0.061 13.0 1.5 0.093 12.4 0.0 2.0 2 1 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO26705.1 - 0.11 11.3 0.0 0.23 10.3 0.0 1.5 1 0 0 1 1 1 0 Kinase-like MCPsignal PF00015.16 KOO26706.1 - 0.024 14.1 1.4 0.039 13.5 1.0 1.2 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain AAA_33 PF13671.1 KOO26708.1 - 1.5e-17 63.7 2.0 1.4e-16 60.7 0.3 2.8 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 KOO26708.1 - 4.1e-07 30.3 0.1 0.017 15.4 0.0 2.5 1 1 1 2 2 2 2 AAA domain RNA_ligase PF09414.5 KOO26708.1 - 3.4e-06 26.9 0.0 5.5e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 RNA ligase AAA_17 PF13207.1 KOO26708.1 - 1.5e-05 25.7 0.0 5.3e-05 24.0 0.0 2.0 1 0 0 1 1 1 1 AAA domain SKI PF01202.17 KOO26708.1 - 8.5e-05 22.4 0.1 0.16 11.7 0.0 3.1 3 0 0 3 3 3 1 Shikimate kinase Zeta_toxin PF06414.7 KOO26708.1 - 0.00047 19.3 0.2 0.0018 17.4 0.0 1.9 1 1 1 2 2 2 1 Zeta toxin tRNA_lig_kinase PF08303.6 KOO26708.1 - 0.0019 18.0 0.0 0.0042 16.9 0.0 1.7 1 1 0 1 1 1 1 tRNA ligase kinase domain MMR_HSR1 PF01926.18 KOO26708.1 - 0.0072 16.2 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase KTI12 PF08433.5 KOO26708.1 - 0.008 15.4 0.2 0.048 12.8 0.2 2.0 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_22 PF13401.1 KOO26708.1 - 0.017 15.2 0.0 0.042 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 KOO26708.1 - 0.02 14.8 0.6 0.11 12.4 0.3 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_5 PF07728.9 KOO26708.1 - 0.021 14.5 0.0 0.047 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.22 KOO26708.1 - 0.035 14.4 0.0 0.068 13.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter 6PF2K PF01591.13 KOO26708.1 - 0.046 12.7 0.0 0.077 12.0 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_28 PF13521.1 KOO26708.1 - 0.054 13.4 0.0 0.2 11.6 0.0 2.0 2 0 0 2 2 1 0 AAA domain AAA PF00004.24 KOO26708.1 - 0.17 12.1 0.1 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Exostosin PF03016.10 KOO26711.1 - 4e-20 72.0 0.0 1.6e-19 70.0 0.0 1.8 1 1 0 1 1 1 1 Exostosin family TPR_11 PF13414.1 KOO26712.1 - 3.9e-09 36.0 4.9 3.8e-05 23.2 0.7 2.4 2 0 0 2 2 2 2 TPR repeat TPR_14 PF13428.1 KOO26712.1 - 2.1 9.2 17.0 1.6 9.6 1.7 3.6 2 2 1 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO26712.1 - 3.9 7.6 6.4 46 4.2 0.2 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO26712.1 - 7.4 6.5 11.1 5 7.0 4.6 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat ECH PF00378.15 KOO26714.1 - 5.8e-29 100.9 0.0 6.6e-29 100.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Thioredoxin PF00085.15 KOO26715.1 - 7e-10 38.5 0.1 8.9e-10 38.1 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 KOO26715.1 - 0.0034 17.4 0.1 1.3 9.1 0.0 2.2 1 1 1 2 2 2 2 Thioredoxin-like ERp29_N PF07912.8 KOO26715.1 - 0.11 12.4 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 ERp29, N-terminal domain DUF521 PF04412.8 KOO26717.1 - 1.9e-99 332.9 0.1 2.3e-99 332.6 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF521) DnaJ PF00226.26 KOO26718.1 - 1.2e-19 69.7 0.1 2.6e-19 68.7 0.1 1.6 1 0 0 1 1 1 1 DnaJ domain TPR_11 PF13414.1 KOO26718.1 - 2.1e-13 49.6 5.9 4e-07 29.5 0.1 2.8 2 1 2 4 4 4 3 TPR repeat TPR_2 PF07719.12 KOO26718.1 - 2.7e-09 36.2 5.2 0.0036 17.0 0.1 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO26718.1 - 1.1e-06 27.9 1.9 0.0051 16.3 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO26718.1 - 7e-06 25.9 2.7 0.00019 21.2 1.5 2.6 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO26718.1 - 8.8e-06 26.2 2.6 8.8e-06 26.2 1.8 4.0 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 KOO26718.1 - 0.0056 17.0 2.2 1.2 9.7 0.0 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO26718.1 - 0.0069 16.6 1.1 0.076 13.3 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO26718.1 - 4.4 8.2 21.1 0.23 12.1 0.7 4.8 3 1 2 5 5 5 0 Tetratricopeptide repeat SnoaL_2 PF12680.2 KOO26719.1 - 0.002 18.4 0.0 0.0035 17.7 0.0 1.3 1 1 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.1 KOO26719.1 - 0.012 15.7 0.0 0.016 15.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Actin PF00022.14 KOO26720.1 - 1.2e-33 116.1 0.0 5.9e-18 64.4 0.0 2.1 2 0 0 2 2 2 2 Actin WD40 PF00400.27 KOO26721.1 - 6.3e-49 162.1 18.4 7.1e-06 25.7 0.1 12.3 12 1 0 12 12 12 9 WD domain, G-beta repeat PQQ_3 PF13570.1 KOO26721.1 - 8.6e-06 25.8 8.3 1.8 8.9 0.0 6.6 7 0 0 7 7 7 3 PQQ-like domain Reg_prop PF07494.6 KOO26721.1 - 0.0074 16.1 0.9 34 4.9 0.0 5.0 5 0 0 5 5 5 1 Two component regulator propeller Nucleoporin_N PF08801.6 KOO26721.1 - 0.15 10.7 3.7 5.5 5.6 0.0 3.7 1 1 3 4 4 4 0 Nup133 N terminal like zf-RING_2 PF13639.1 KOO26722.1 - 5.7e-13 48.4 9.6 1.1e-12 47.5 6.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 KOO26722.1 - 3.9e-10 39.2 5.2 6.4e-10 38.5 3.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO26722.1 - 1.7e-09 37.5 7.4 2.7e-09 36.8 5.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO26722.1 - 8.5e-07 28.5 7.9 1.4e-06 27.8 5.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 KOO26722.1 - 2.3e-06 27.5 8.1 4.1e-06 26.8 5.6 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 KOO26722.1 - 8.5e-05 22.1 6.8 0.00013 21.5 4.7 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-Apc11 PF12861.2 KOO26722.1 - 0.0052 16.5 4.8 0.0096 15.7 3.3 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger SAP PF02037.22 KOO26722.1 - 0.012 15.1 0.3 0.024 14.1 0.2 1.6 1 0 0 1 1 1 0 SAP domain U-box PF04564.10 KOO26722.1 - 0.027 14.4 0.0 0.063 13.2 0.0 1.6 1 0 0 1 1 1 0 U-box domain Prok-RING_4 PF14447.1 KOO26722.1 - 0.069 12.7 3.4 0.14 11.7 2.4 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Prok-RING_1 PF14446.1 KOO26722.1 - 0.11 12.2 5.7 0.88 9.3 4.0 2.0 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 zf-RING_UBOX PF13445.1 KOO26722.1 - 0.16 11.6 4.4 0.42 10.3 3.0 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-Nse PF11789.3 KOO26722.1 - 0.2 11.1 3.6 0.39 10.2 2.5 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.1 KOO26722.1 - 0.23 11.0 3.3 0.44 10.1 2.3 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.2 KOO26722.1 - 0.25 11.4 8.4 0.46 10.5 5.8 1.4 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.3 KOO26722.1 - 1.6 8.7 6.7 7.3 6.6 4.7 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain Filamin PF00630.14 KOO26723.1 - 1.9e-22 79.6 0.0 2.6e-14 53.6 0.0 4.8 4 2 0 4 4 4 4 Filamin/ABP280 repeat PhoD PF09423.5 KOO26724.1 - 9e-14 50.8 0.0 5.7e-13 48.2 0.0 2.0 1 1 0 1 1 1 1 PhoD-like phosphatase tRNA-synt_2b PF00587.20 KOO26725.1 - 1.6e-54 184.0 0.0 2.3e-54 183.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 KOO26725.1 - 1.9e-19 69.3 0.0 4.3e-19 68.2 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain Dpy-30 PF05186.8 KOO26725.1 - 0.01 15.3 0.0 0.019 14.4 0.0 1.5 1 0 0 1 1 1 0 Dpy-30 motif Mito_carr PF00153.22 KOO26726.1 - 2.2e-16 59.3 10.6 1.5e-05 24.5 0.2 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF2196 PF09962.4 KOO26726.1 - 0.044 13.5 0.1 0.085 12.6 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2196) DUF964 PF06133.6 KOO26727.1 - 0.41 10.6 10.6 0.19 11.7 5.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF964) Bap31 PF05529.7 KOO26727.1 - 1.3 8.4 5.1 2 7.8 3.6 1.2 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like TMF_DNA_bd PF12329.3 KOO26727.1 - 1.6 8.5 12.3 2.9 7.7 5.3 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding BLOC1_2 PF10046.4 KOO26729.1 - 0.031 14.4 0.1 5.6 7.1 0.0 3.7 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 YkyA PF10368.4 KOO26729.1 - 9.5 5.4 12.9 0.36 10.1 1.3 2.9 3 0 0 3 3 3 0 Putative cell-wall binding lipoprotein Ank_5 PF13857.1 KOO26730.1 - 0.015 15.5 0.0 0.034 14.4 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO26730.1 - 0.058 13.7 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO26730.1 - 0.1 13.1 0.0 1.5 9.4 0.0 2.2 2 0 0 2 2 2 0 Ankyrin repeats (many copies) DUF2413 PF10310.4 KOO26731.1 - 4.3 6.0 7.3 6.1 5.5 5.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) PBP PF01161.15 KOO26732.1 - 1e-17 64.3 0.0 2.1e-17 63.3 0.0 1.5 1 1 0 1 1 1 1 Phosphatidylethanolamine-binding protein Glyco_hydro_76 PF03663.9 KOO26733.1 - 6.8e-19 68.4 0.1 8.3e-19 68.1 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 HSP70 PF00012.15 KOO26734.1 - 3.9e-08 31.6 0.0 5.1e-08 31.2 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein STOP PF05217.7 KOO26734.1 - 0.002 17.8 18.3 0.016 14.9 5.6 2.4 1 1 1 2 2 2 2 STOP protein Pkinase PF00069.20 KOO26735.1 - 3.1e-53 180.5 0.0 3.8e-53 180.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO26735.1 - 2.3e-22 79.3 0.0 3.1e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO26735.1 - 0.016 14.2 0.1 0.025 13.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FKBP_C PF00254.23 KOO26736.1 - 5.1e-26 90.5 0.0 7.7e-26 89.9 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF3138 PF11336.3 KOO26737.1 - 0.82 7.7 5.9 1.1 7.3 3.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) CSD PF00313.17 KOO26738.1 - 2.1e-17 62.6 0.0 3.3e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.6 KOO26738.1 - 4.1e-06 26.2 0.1 8.7e-06 25.1 0.1 1.4 1 0 0 1 1 1 1 Ribonuclease B OB domain RNA_pol PF00940.14 KOO26739.1 - 3.5e-129 430.8 0.0 4.6e-129 430.4 0.0 1.2 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.1 KOO26739.1 - 1.3e-18 67.3 1.6 7.3e-10 38.5 0.0 3.2 3 0 0 3 3 3 3 DNA-directed RNA polymerase N-terminal Ion_trans_2 PF07885.11 KOO26740.1 - 1.1e-16 60.2 18.3 1.4e-11 43.9 1.8 2.8 3 0 0 3 3 3 2 Ion channel Lig_chan PF00060.21 KOO26740.1 - 8.3e-05 22.3 0.1 0.00017 21.3 0.1 1.5 1 0 0 1 1 1 1 Ligand-gated ion channel IRK PF01007.15 KOO26740.1 - 0.0082 14.9 0.4 0.0082 14.9 0.3 2.0 2 0 0 2 2 2 1 Inward rectifier potassium channel EF-hand_1 PF00036.27 KOO26741.1 - 5.7e-19 65.9 0.2 2.1e-05 23.5 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_5 PF13202.1 KOO26741.1 - 1.8e-18 64.9 1.4 2.4e-07 29.7 0.1 3.6 3 1 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 KOO26741.1 - 3.9e-16 57.4 0.8 4.6e-05 22.9 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.1 KOO26741.1 - 1.1e-15 56.9 0.7 0.00035 20.1 0.0 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.1 KOO26741.1 - 4.4e-14 52.3 0.1 2.2e-08 34.1 0.1 2.6 1 1 0 1 1 1 1 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO26741.1 - 0.015 15.3 0.1 8.3 6.4 0.0 2.9 2 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region DUF533 PF04391.7 KOO26741.1 - 0.022 14.1 1.1 0.12 11.7 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF533) RNA_pol_Rpc82 PF05645.8 KOO26742.1 - 0.0017 17.9 0.0 0.0046 16.5 0.0 1.8 1 1 0 1 1 1 1 RNA polymerase III subunit RPC82 Acetyltransf_1 PF00583.19 KOO26743.1 - 7.2e-07 29.1 0.3 2.4e-06 27.4 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 KOO26743.1 - 2.4e-05 24.4 0.1 6e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 KOO26743.1 - 5.4e-05 23.2 0.0 0.00011 22.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain 2OG-FeII_Oxy PF03171.15 KOO26743.1 - 0.033 14.4 0.0 0.077 13.2 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Acetyltransf_CG PF14542.1 KOO26743.1 - 0.071 13.0 0.1 0.25 11.2 0.0 1.9 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase PX PF00787.19 KOO26745.1 - 0.00048 19.9 0.0 0.0011 18.7 0.0 1.5 1 0 0 1 1 1 1 PX domain MxiH PF09392.5 KOO26745.1 - 0.045 14.3 0.0 0.64 10.6 0.0 2.3 1 1 0 1 1 1 0 Type III secretion needle MxiH like Annexin PF00191.15 KOO26746.1 - 6.2e-76 250.2 5.8 2.4e-11 43.3 0.3 8.5 8 0 0 8 8 8 8 Annexin DUF3432 PF11914.3 KOO26746.1 - 1.4 8.9 15.2 3.4 7.7 10.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3432) PAS_9 PF13426.1 KOO26747.1 - 1.7e-96 317.4 0.0 8.9e-18 64.5 0.0 7.1 7 0 0 7 7 7 6 PAS domain PAS PF00989.19 KOO26747.1 - 2e-25 88.7 0.0 1.2e-05 25.0 0.0 6.1 6 0 0 6 6 6 5 PAS fold PAS_8 PF13188.1 KOO26747.1 - 6.5e-16 57.5 0.1 0.097 12.5 0.0 5.9 5 0 0 5 5 5 4 PAS domain PAS_3 PF08447.6 KOO26747.1 - 8.9e-15 54.5 0.0 0.039 14.0 0.0 5.7 5 0 0 5 5 5 4 PAS fold PAS_4 PF08448.5 KOO26747.1 - 3.1e-13 49.7 1.0 0.16 12.0 0.1 6.5 6 0 0 6 6 6 4 PAS fold RGS PF00615.14 KOO26747.1 - 0.0017 18.4 0.2 0.43 10.6 0.0 4.1 5 0 0 5 5 5 1 Regulator of G protein signaling domain DUF331 PF03889.8 KOO26747.1 - 0.05 12.8 0.0 0.14 11.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function PAS_9 PF13426.1 KOO26748.1 - 8.8e-34 116.0 0.0 1.8e-17 63.6 0.0 2.7 2 0 0 2 2 2 2 PAS domain PAS PF00989.19 KOO26748.1 - 4.7e-09 36.0 0.1 0.00039 20.1 0.0 3.2 3 0 0 3 3 3 2 PAS fold PAS_8 PF13188.1 KOO26748.1 - 1.7e-06 27.6 0.0 0.015 15.1 0.0 2.9 2 0 0 2 2 2 2 PAS domain RGS PF00615.14 KOO26748.1 - 6.3e-05 23.0 0.0 0.17 11.9 0.0 2.7 2 0 0 2 2 2 2 Regulator of G protein signaling domain PAS_4 PF08448.5 KOO26748.1 - 0.0019 18.2 0.4 0.59 10.1 0.0 3.3 3 0 0 3 3 3 1 PAS fold PAS_3 PF08447.6 KOO26748.1 - 0.0028 17.7 0.0 0.059 13.4 0.0 2.9 2 0 0 2 2 2 1 PAS fold XkdW PF09636.5 KOO26748.1 - 0.016 15.0 0.4 0.052 13.4 0.2 1.9 1 0 0 1 1 1 0 XkdW protein zf-ribbon_3 PF13248.1 KOO26749.1 - 0.0061 15.7 2.0 0.15 11.2 0.1 2.5 2 0 0 2 2 2 1 zinc-ribbon domain zinc_ribbon_2 PF13240.1 KOO26749.1 - 0.057 12.9 2.0 4 7.0 0.1 2.6 2 0 0 2 2 2 0 zinc-ribbon domain DZR PF12773.2 KOO26749.1 - 0.21 11.4 3.7 0.68 9.7 0.9 2.7 2 1 0 2 2 2 0 Double zinc ribbon DNA_ligase_aden PF01653.13 KOO26749.1 - 0.22 10.4 0.4 0.4 9.5 0.0 1.5 2 0 0 2 2 2 0 NAD-dependent DNA ligase adenylation domain zinc_ribbon_5 PF13719.1 KOO26749.1 - 0.87 9.2 5.4 11 5.7 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain TFIIS_C PF01096.13 KOO26749.1 - 1 9.0 7.5 14 5.4 0.0 4.3 5 0 0 5 5 5 0 Transcription factor S-II (TFIIS) zinc_ribbon_4 PF13717.1 KOO26749.1 - 4.3 7.1 7.1 13 5.6 0.1 3.2 3 0 0 3 3 3 0 zinc-ribbon domain TPMT PF05724.6 KOO26750.1 - 7.8e-17 61.4 0.1 5.4e-15 55.4 0.1 2.2 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_26 PF13659.1 KOO26750.1 - 0.0013 18.7 0.1 0.0044 17.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO26750.1 - 0.002 18.5 0.0 0.0046 17.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO26750.1 - 0.0029 18.1 0.0 0.0059 17.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO26750.1 - 0.02 14.5 0.0 0.033 13.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 KOO26750.1 - 0.03 14.7 0.0 0.055 13.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain TAF4 PF05236.9 KOO26751.1 - 0.14 11.4 12.6 0.014 14.6 5.7 1.5 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family Nop53 PF07767.6 KOO26751.1 - 1.1 8.2 21.0 1.3 7.9 14.6 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) bZIP_Maf PF03131.12 KOO26751.1 - 3.3 8.0 7.5 0.22 11.8 0.6 2.0 2 0 0 2 2 2 0 bZIP Maf transcription factor Arm PF00514.18 KOO26752.1 - 3.1e-55 182.2 31.8 2.6e-07 30.1 0.2 9.6 9 0 0 9 9 9 9 Armadillo/beta-catenin-like repeat RPAP1_C PF08620.5 KOO26752.1 - 1.6e-08 34.2 0.0 6.7 6.6 0.0 7.6 7 1 1 8 8 8 1 RPAP1-like, C-terminal Atx10homo_assoc PF09759.4 KOO26752.1 - 1.7e-07 30.8 11.8 0.0068 16.1 0.5 5.8 4 2 2 7 7 7 4 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.1 KOO26752.1 - 2.5e-07 30.9 29.1 0.046 14.2 0.1 7.0 5 2 3 8 8 8 5 HEAT-like repeat Arm_2 PF04826.8 KOO26752.1 - 1.5e-06 27.5 10.1 0.039 13.0 0.1 4.1 1 1 4 5 5 5 4 Armadillo-like HEAT_2 PF13646.1 KOO26752.1 - 0.00026 21.2 38.3 0.19 12.0 6.0 4.5 1 1 3 5 5 5 4 HEAT repeats DUF383 PF04063.9 KOO26752.1 - 0.00088 18.8 0.6 14 5.1 0.0 4.4 1 1 2 3 3 3 0 Domain of unknown function (DUF383) ACC_central PF08326.7 KOO26752.1 - 0.001 17.3 0.3 7.6 4.5 0.0 3.8 3 1 1 4 4 4 1 Acetyl-CoA carboxylase, central region Peptidase_S41 PF03572.13 KOO26752.1 - 0.0019 17.6 2.0 4.5 6.6 0.0 4.3 1 1 2 4 4 4 1 Peptidase family S41 RPT PF13446.1 KOO26752.1 - 0.0036 16.6 11.3 10 5.5 0.0 6.5 7 1 1 8 8 8 0 A repeated domain in UCH-protein DUF1676 PF07898.8 KOO26752.1 - 0.021 15.1 2.9 20 5.5 0.0 5.6 3 3 4 7 7 7 0 Protein of unknown function (DUF1676) DUF3954 PF13128.1 KOO26752.1 - 0.022 14.1 0.0 40 3.7 0.0 4.4 5 0 0 5 5 5 0 Protein of unknown function (DUF3954) PhnJ PF06007.6 KOO26752.1 - 0.028 13.1 0.1 1.9 7.2 0.0 3.4 3 1 2 5 5 5 0 Phosphonate metabolism protein PhnJ AAA_assoc_C PF09821.4 KOO26752.1 - 0.036 14.3 1.6 1.5 9.1 0.1 3.9 2 1 3 5 5 5 0 C-terminal AAA-associated domain Op_neuropeptide PF08035.6 KOO26752.1 - 0.064 12.8 5.3 2.1e+02 1.6 0.0 6.2 7 0 0 7 7 7 0 Opioids neuropeptide Antirestrict PF03230.8 KOO26752.1 - 0.8 9.7 3.7 24 4.9 0.1 4.0 2 1 2 4 4 4 0 Antirestriction protein IMS PF00817.15 KOO26753.1 - 8.9e-41 139.1 0.0 1.5e-40 138.4 0.0 1.4 1 1 0 1 1 1 1 impB/mucB/samB family Pkinase PF00069.20 KOO26754.1 - 2.8e-51 174.1 0.0 3.8e-51 173.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO26754.1 - 9.4e-27 93.6 0.0 1.3e-26 93.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO26754.1 - 0.021 13.8 0.0 0.037 13.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.4 KOO26754.1 - 0.043 13.1 0.0 0.071 12.4 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.18 KOO26754.1 - 0.055 13.1 0.1 0.26 11.0 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO26754.1 - 0.056 12.3 0.0 3.7 6.4 0.0 2.3 2 0 0 2 2 2 0 Kinase-like Ndc1_Nup PF09531.5 KOO26754.1 - 0.47 8.8 3.5 0.63 8.3 2.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF2413 PF10310.4 KOO26754.1 - 0.76 8.5 6.9 1.3 7.7 4.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Peptidase_S64 PF08192.6 KOO26754.1 - 1.1 7.4 3.1 1.5 7.0 2.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 Pol_alpha_B_N PF08418.5 KOO26754.1 - 1.9 7.9 9.4 2.9 7.3 6.5 1.2 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal DAGAT PF03982.8 KOO26756.1 - 4.9e-24 84.5 0.0 7.7e-24 83.9 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol acyltransferase ABC_tran PF00005.22 KOO26757.1 - 6.4e-22 78.3 0.0 8e-22 78.0 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 KOO26757.1 - 2.5e-14 53.9 0.1 6e-07 29.7 0.0 2.1 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 KOO26757.1 - 6.4e-05 23.1 0.1 0.00013 22.1 0.1 1.4 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 KOO26757.1 - 0.0002 21.3 0.3 0.0014 18.5 0.1 2.0 1 1 0 2 2 2 1 AAA domain AAA_29 PF13555.1 KOO26757.1 - 0.00028 20.3 0.0 0.00052 19.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.1 KOO26757.1 - 0.00059 19.8 3.8 0.00097 19.1 2.6 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.1 KOO26757.1 - 0.001 18.4 2.5 0.0048 16.3 1.7 1.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.1 KOO26757.1 - 0.0051 16.4 2.2 0.044 13.3 1.5 2.0 1 1 0 1 1 1 1 AAA domain MutS_V PF00488.16 KOO26757.1 - 0.0087 15.4 0.0 0.14 11.5 0.0 2.1 2 0 0 2 2 2 1 MutS domain V AAA_15 PF13175.1 KOO26757.1 - 0.0091 15.0 0.0 0.047 12.7 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain DUF258 PF03193.11 KOO26757.1 - 0.011 14.9 0.0 0.017 14.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_23 PF13476.1 KOO26757.1 - 0.018 15.3 0.0 0.027 14.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 KOO26757.1 - 0.02 14.3 0.2 0.33 10.3 0.0 2.0 1 1 1 2 2 2 0 AAA-like domain SMC_N PF02463.14 KOO26757.1 - 0.025 13.8 0.1 0.86 8.7 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain NACHT PF05729.7 KOO26757.1 - 0.026 14.1 4.3 0.22 11.1 0.0 2.4 2 1 0 2 2 2 0 NACHT domain MMR_HSR1 PF01926.18 KOO26757.1 - 0.035 14.0 0.0 0.052 13.5 0.0 1.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase Miro PF08477.8 KOO26757.1 - 0.051 14.0 0.0 0.073 13.5 0.0 1.3 1 0 0 1 1 1 0 Miro-like protein Zeta_toxin PF06414.7 KOO26757.1 - 0.072 12.1 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin FtsK_SpoIIIE PF01580.13 KOO26757.1 - 0.077 12.4 0.0 0.27 10.6 0.0 1.8 2 1 1 3 3 3 0 FtsK/SpoIIIE family SbcCD_C PF13558.1 KOO26757.1 - 0.081 12.8 0.2 0.081 12.8 0.1 2.1 1 1 1 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_14 PF13173.1 KOO26757.1 - 0.084 12.7 0.0 1.8 8.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 KOO26757.1 - 0.11 13.2 0.2 0.16 12.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 KOO26757.1 - 0.12 12.2 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.3 KOO26757.1 - 0.15 9.3 0.0 0.2 8.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) PP2C PF00481.16 KOO26758.1 - 9.8e-48 162.7 0.0 1.1e-47 162.6 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C MORN PF02493.15 KOO26759.1 - 4.1e-54 177.1 61.9 9.9e-07 28.1 0.4 10.6 10 0 0 10 10 10 10 MORN repeat Prismane PF03063.15 KOO26759.1 - 0.26 9.6 0.0 0.35 9.1 0.0 1.1 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family Histone PF00125.19 KOO26761.1 - 6.2e-09 35.8 0.1 5.8e-06 26.3 0.0 3.4 3 0 0 3 3 3 1 Core histone H2A/H2B/H3/H4 Glyco_transf_25 PF01755.12 KOO26761.1 - 0.00051 19.7 0.0 0.0037 16.9 0.0 2.2 2 1 0 2 2 2 1 Glycosyltransferase family 25 (LPS biosynthesis protein) FAD_binding_7 PF03441.9 KOO26762.1 - 4.7e-79 265.4 0.5 6.3e-79 265.0 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.13 KOO26762.1 - 1.1e-22 80.5 0.1 9.3e-11 41.7 1.5 2.5 2 0 0 2 2 2 2 DNA photolyase SURF4 PF02077.10 KOO26763.1 - 2.1e-48 165.0 2.1 2.5e-48 164.7 1.5 1.1 1 0 0 1 1 1 1 SURF4 family DoxX PF07681.7 KOO26763.1 - 0.12 12.8 14.8 3.6 8.0 5.9 2.9 2 1 0 2 2 2 0 DoxX Histone PF00125.19 KOO26764.1 - 3.4e-12 46.3 0.1 0.00015 21.7 0.0 2.6 3 0 0 3 3 3 2 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.8 KOO26764.1 - 0.051 13.3 0.0 0.36 10.5 0.0 2.2 2 0 0 2 2 2 0 Bromodomain associated SHIPPO-rpt PF07004.7 KOO26765.1 - 5.3e-10 39.6 17.0 0.11 13.4 0.2 5.5 5 0 0 5 5 5 4 Sperm-tail PG-rich repeat Fasciclin PF02469.17 KOO26766.1 - 1.4e-32 112.3 0.0 2.1e-32 111.7 0.0 1.3 1 0 0 1 1 1 1 Fasciclin domain S1 PF00575.18 KOO26766.1 - 1.3e-22 79.6 5.7 1.2e-11 44.5 0.1 2.5 1 1 1 2 2 2 2 S1 RNA binding domain MFS_1 PF07690.11 KOO26766.1 - 2.2e-12 46.3 33.3 6e-12 44.9 23.1 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.15 KOO26766.1 - 4.9e-07 28.1 1.6 0.00022 19.4 0.1 2.3 2 0 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family S1_2 PF13509.1 KOO26766.1 - 0.0036 17.1 0.0 0.77 9.7 0.0 2.5 1 1 1 2 2 2 2 S1 domain CSD PF00313.17 KOO26766.1 - 0.12 12.1 2.3 0.57 10.0 0.7 2.2 1 1 1 2 2 2 0 'Cold-shock' DNA-binding domain Misat_Tub_SegII PF10644.4 KOO26767.1 - 1.8e-18 66.6 0.0 3.1e-18 65.9 0.0 1.3 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.1 KOO26767.1 - 1.5e-11 44.0 0.0 1.3e-10 41.0 0.0 2.3 3 0 0 3 3 3 1 Tubulin domain Tubulin PF00091.20 KOO26767.1 - 1.8e-06 27.9 0.0 0.024 14.4 0.0 2.2 2 0 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain UnbV_ASPIC PF07593.7 KOO26768.1 - 0.041 13.5 0.0 0.074 12.7 0.0 1.4 1 0 0 1 1 1 0 ASPIC and UnbV Glycoamylase PF10091.4 KOO26768.1 - 0.053 12.5 0.1 0.099 11.6 0.0 1.5 2 0 0 2 2 2 0 Putative glucoamylase COPIIcoated_ERV PF07970.7 KOO26769.1 - 4.2e-43 147.5 0.2 6e-43 147.0 0.1 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 KOO26769.1 - 1.1e-27 95.7 0.0 2.7e-27 94.5 0.0 1.6 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Imm-NTF2-2 PF15631.1 KOO26769.1 - 0.13 12.2 0.1 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 NTF2 fold immunity protein Mur_ligase_C PF02875.16 KOO26770.1 - 0.0084 16.1 0.1 0.052 13.6 0.0 2.2 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain EF-hand_6 PF13405.1 KOO26771.1 - 3.5e-09 35.7 0.9 0.00025 20.6 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO26771.1 - 4.7e-08 31.7 0.4 2.5e-05 23.2 0.1 2.6 2 1 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO26771.1 - 8.1e-08 32.2 0.1 1.6e-07 31.3 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO26771.1 - 2.8e-06 26.8 0.0 5.6e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair C2 PF00168.25 KOO26771.1 - 2.4e-05 24.1 0.0 0.011 15.5 0.0 2.3 2 0 0 2 2 2 2 C2 domain EF-hand_5 PF13202.1 KOO26771.1 - 3.3e-05 23.0 1.6 0.12 11.7 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.1 KOO26771.1 - 0.029 14.0 0.0 0.052 13.2 0.0 1.4 1 0 0 1 1 1 0 EF hand EF-hand_9 PF14658.1 KOO26771.1 - 0.034 14.0 0.0 0.092 12.6 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain SPRY PF00622.23 KOO26772.1 - 7.7e-05 22.7 0.0 0.00014 21.8 0.0 1.5 1 1 0 1 1 1 1 SPRY domain IF-2B PF01008.12 KOO26773.1 - 6.2e-59 199.2 0.0 7.7e-59 198.9 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family 6PGD PF00393.14 KOO26773.1 - 0.02 14.1 0.0 0.027 13.6 0.0 1.1 1 0 0 1 1 1 0 6-phosphogluconate dehydrogenase, C-terminal domain FAD_binding_3 PF01494.14 KOO26773.1 - 0.021 13.8 0.0 0.033 13.2 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain CBFD_NFYB_HMF PF00808.18 KOO26773.1 - 0.04 13.9 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Arm PF00514.18 KOO26774.1 - 4.9e-61 200.6 21.8 1.9e-12 46.5 0.1 9.0 8 1 0 8 8 8 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO26774.1 - 2.3e-20 72.6 2.6 4.7e-06 26.7 0.0 5.7 2 2 3 5 5 5 5 HEAT repeats HEAT_EZ PF13513.1 KOO26774.1 - 3e-17 62.5 7.0 0.00018 21.8 0.1 6.1 4 2 3 7 7 7 5 HEAT-like repeat IBB PF01749.15 KOO26774.1 - 2.7e-10 40.2 0.5 5.9e-10 39.1 0.3 1.5 1 0 0 1 1 1 1 Importin beta binding domain HEAT PF02985.17 KOO26774.1 - 4.1e-10 38.8 8.4 0.0058 16.6 0.0 6.8 8 0 0 8 8 8 3 HEAT repeat Ric8 PF10165.4 KOO26774.1 - 0.0015 17.4 0.0 0.0054 15.6 0.0 1.9 1 1 1 2 2 2 1 Guanine nucleotide exchange factor synembryn Proteasom_PSMB PF10508.4 KOO26774.1 - 0.0064 14.8 0.0 0.027 12.7 0.1 1.9 2 0 0 2 2 2 1 Proteasome non-ATPase 26S subunit Trehalase PF01204.13 KOO26775.1 - 1.9e-103 346.8 0.0 4.6e-53 180.6 0.0 2.0 1 1 1 2 2 2 2 Trehalase Glyco_hydro_92 PF07971.7 KOO26775.1 - 0.0046 15.6 0.3 0.0062 15.2 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 PDZ_2 PF13180.1 KOO26776.1 - 5.2e-05 23.0 0.0 6.5e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.19 KOO26776.1 - 0.0054 16.8 0.1 0.007 16.5 0.0 1.2 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) OTU PF02338.14 KOO26777.1 - 0.00012 22.6 0.0 0.00075 20.0 0.0 1.9 1 1 1 2 2 2 2 OTU-like cysteine protease PsbP PF01789.11 KOO26778.1 - 7.3e-11 41.8 0.0 1.2e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 PsbP EF-hand_5 PF13202.1 KOO26782.1 - 9.6e-129 413.5 138.0 5.5e-06 25.4 0.1 28.3 13 13 15 28 28 28 28 EF hand EF-hand_1 PF00036.27 KOO26782.1 - 1.3e-113 361.9 128.7 1.4e-05 24.0 0.3 28.2 11 11 17 28 28 28 28 EF hand EF-hand_6 PF13405.1 KOO26782.1 - 2e-104 332.2 128.7 9.2e-05 22.0 0.4 28.3 9 9 19 28 28 28 28 EF-hand domain EF-hand_7 PF13499.1 KOO26782.1 - 3.1e-89 293.1 99.2 1.3e-08 34.8 2.8 23.2 2 2 10 12 12 12 12 EF-hand domain pair EF-hand_8 PF13833.1 KOO26782.1 - 3.2e-62 205.9 117.2 0.0012 18.3 1.0 28.0 12 12 15 27 27 27 22 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO26782.1 - 6.9e-12 45.4 26.5 1.1 9.3 0.0 17.8 4 4 9 13 13 13 1 Secreted protein acidic and rich in cysteine Ca binding region SHOCT PF09851.4 KOO26782.1 - 1.6e-08 33.7 19.7 3.8 7.1 0.0 13.6 16 0 0 16 16 16 2 Short C-terminal domain EF-hand_4 PF12763.2 KOO26782.1 - 4.6e-07 29.5 28.8 0.21 11.3 0.1 11.2 4 3 8 13 13 13 1 Cytoskeletal-regulatory complex EF hand Trypan_PARP PF05887.6 KOO26782.1 - 0.009 15.8 7.6 0.019 14.7 5.3 1.4 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) CENP-F_leu_zip PF10473.4 KOO26782.1 - 0.03 14.1 6.4 0.7 9.7 2.0 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3166 PF11365.3 KOO26782.1 - 0.031 14.7 7.0 0.35 11.3 2.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3166) Macoilin PF09726.4 KOO26782.1 - 0.046 12.0 3.4 0.062 11.5 2.3 1.1 1 0 0 1 1 1 0 Transmembrane protein DUF4201 PF13870.1 KOO26782.1 - 0.15 11.5 12.4 0.034 13.5 5.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Spc7 PF08317.6 KOO26782.1 - 0.46 9.1 5.3 0.69 8.5 3.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF972 PF06156.8 KOO26782.1 - 0.74 10.1 8.5 6.8 7.0 0.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF972) BMFP PF04380.8 KOO26782.1 - 0.76 9.9 14.8 0.041 14.0 2.5 4.4 5 0 0 5 5 3 0 Membrane fusogenic activity Cbl_N2 PF02761.9 KOO26782.1 - 1.2 9.2 2.9 21 5.2 0.0 4.6 5 1 1 6 6 3 0 CBL proto-oncogene N-terminus, EF hand-like domain TPD52 PF04201.10 KOO26782.1 - 1.2 8.8 5.5 4.2 7.0 0.9 2.3 2 0 0 2 2 2 0 Tumour protein D52 family CCDC155 PF14662.1 KOO26782.1 - 1.3 8.5 11.3 0.36 10.3 4.8 1.9 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 Phage_XkdX PF09693.5 KOO26782.1 - 1.5 8.3 7.8 87 2.7 0.1 6.4 9 0 0 9 9 8 0 Phage uncharacterised protein (Phage_XkdX) Med9 PF07544.8 KOO26782.1 - 2 8.2 6.1 2.8 7.7 1.6 2.4 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Seryl_tRNA_N PF02403.17 KOO26782.1 - 4.8 7.2 7.5 2.1 8.3 3.3 1.7 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain IncA PF04156.9 KOO26782.1 - 8.9 5.8 9.4 18 4.8 6.5 1.4 1 1 0 1 1 1 0 IncA protein FrhB_FdhB_C PF04432.8 KOO26783.1 - 1.9e-16 59.8 0.0 5.5e-16 58.3 0.0 1.7 1 1 0 1 1 1 1 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus FrhB_FdhB_N PF04422.8 KOO26783.1 - 9.1e-13 47.8 0.0 1.8e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term LRR_5 PF13306.1 KOO26784.1 - 9.4e-92 303.4 4.0 1.3e-35 121.8 0.1 3.7 2 1 1 3 3 3 3 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO26784.1 - 7.4e-36 121.7 1.4 5.1e-06 26.1 0.0 10.9 6 2 5 11 11 11 8 Leucine rich repeat LRR_6 PF13516.1 KOO26784.1 - 1.4e-19 67.9 16.3 0.015 15.2 0.0 12.0 10 0 0 10 10 10 6 Leucine Rich repeat LRR_1 PF00560.28 KOO26784.1 - 6.5e-05 22.4 2.8 1.4e+02 3.1 0.0 9.4 11 0 0 11 11 11 0 Leucine Rich Repeat LRR_4 PF12799.2 KOO26784.1 - 0.0011 18.5 3.8 11 5.8 0.1 6.0 6 0 0 6 6 6 1 Leucine Rich repeats (2 copies) EF-hand_7 PF13499.1 KOO26786.1 - 2.8e-15 56.1 0.0 7.6e-06 25.9 0.0 3.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO26786.1 - 1.3e-13 49.6 0.1 2.1e-05 24.0 0.0 4.8 5 0 0 5 5 5 2 EF-hand domain EF-hand_1 PF00036.27 KOO26786.1 - 9.2e-10 37.1 0.0 0.00092 18.3 0.0 4.6 5 0 0 5 5 5 2 EF hand EF-hand_5 PF13202.1 KOO26786.1 - 2e-06 26.8 0.0 0.0018 17.4 0.0 4.1 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.1 KOO26786.1 - 1.4e-05 24.5 0.0 0.24 11.0 0.0 3.6 4 0 0 4 4 4 2 EF-hand domain pair SET PF00856.23 KOO26787.1 - 6.2e-07 29.8 1.6 0.00027 21.2 0.1 3.0 2 1 0 2 2 2 1 SET domain SAF PF08666.7 KOO26787.1 - 0.029 14.7 0.0 2.5 8.5 0.0 2.7 3 0 0 3 3 3 0 SAF domain Metal_resist PF13801.1 KOO26787.1 - 0.032 14.2 0.1 0.06 13.3 0.1 1.4 1 0 0 1 1 1 0 Heavy-metal resistance DUF1789 PF08748.6 KOO26787.1 - 0.15 12.1 2.1 0.27 11.3 1.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1789) DUF3530 PF12048.3 KOO26787.1 - 9.7 5.0 7.3 15 4.4 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) WD40 PF00400.27 KOO26789.1 - 1.5e-22 78.5 6.1 5.4e-09 35.5 0.0 5.0 5 0 0 5 5 5 4 WD domain, G-beta repeat Glyco_hydro_43 PF04616.9 KOO26789.1 - 6.7e-22 77.9 1.1 1.2e-21 77.0 0.8 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 F5_F8_type_C PF00754.20 KOO26789.1 - 9.7e-08 31.9 0.1 9.7e-07 28.6 0.0 2.8 2 1 0 2 2 2 1 F5/8 type C domain fn3 PF00041.16 KOO26789.1 - 5e-06 26.5 0.0 2.1e-05 24.5 0.0 2.2 1 0 0 1 1 1 1 Fibronectin type III domain Nup160 PF11715.3 KOO26789.1 - 0.098 10.7 0.0 3.9 5.5 0.0 2.2 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Arm PF00514.18 KOO26790.1 - 0.15 11.9 4.3 6.8 6.6 0.1 3.5 3 1 0 3 3 3 0 Armadillo/beta-catenin-like repeat eIF3_subunit PF08597.5 KOO26791.1 - 0.13 11.8 5.1 0.19 11.2 3.6 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Complex1_LYR PF05347.10 KOO26792.1 - 0.018 14.8 0.2 0.018 14.8 0.1 1.5 2 0 0 2 2 2 0 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 KOO26792.1 - 0.021 15.0 0.9 0.024 14.8 0.1 1.5 2 0 0 2 2 2 0 Complex1_LYR-like SpoU_methylase PF00588.14 KOO26793.1 - 9.1e-18 64.5 0.0 1e-16 61.0 0.0 2.1 1 1 0 1 1 1 1 SpoU rRNA Methylase family EF-hand_7 PF13499.1 KOO26794.1 - 6.6e-15 54.9 10.0 1.4e-11 44.3 3.1 2.0 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO26794.1 - 3.6e-12 44.6 7.5 2.8e-06 26.2 0.4 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO26794.1 - 1.7e-11 43.0 2.8 2.9e-05 23.5 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO26794.1 - 1.1e-08 33.9 10.9 0.00017 20.7 0.2 2.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO26794.1 - 7.4e-08 31.8 6.7 1.2e-05 24.8 1.1 2.5 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO26794.1 - 7.7e-07 29.1 0.1 9.2e-07 28.8 0.1 1.1 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.13 KOO26794.1 - 0.47 10.2 1.8 11 5.9 0.2 2.2 2 0 0 2 2 2 0 Dockerin type I repeat EF-hand_10 PF14788.1 KOO26794.1 - 3.1 7.5 5.3 60 3.4 1.1 2.6 1 1 1 2 2 2 0 EF hand Chloroa_b-bind PF00504.16 KOO26795.1 - 9.2e-35 120.2 0.0 1.2e-34 119.8 0.0 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Glyco_transf_8 PF01501.15 KOO26796.1 - 3.6e-08 33.0 0.0 9.6e-08 31.6 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferase family 8 SAPS PF04499.10 KOO26797.1 - 0.17 10.4 0.1 0.17 10.4 0.1 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF4381 PF14316.1 KOO26798.1 - 0.12 12.4 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) LRR_6 PF13516.1 KOO26799.1 - 1.4e-33 111.1 12.5 0.0011 18.8 0.0 10.4 10 0 0 10 10 10 8 Leucine Rich repeat LRR_4 PF12799.2 KOO26799.1 - 1.9e-11 43.3 6.7 0.0027 17.2 0.1 6.8 4 3 3 7 7 7 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO26799.1 - 0.00021 20.8 0.0 2.4e+02 2.4 0.0 7.6 10 0 0 10 10 10 0 Leucine Rich Repeat NACHT PF05729.7 KOO26799.1 - 0.0008 19.1 0.0 0.0016 18.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain LRR_8 PF13855.1 KOO26799.1 - 0.0023 17.6 5.1 2.2 8.0 0.3 4.8 4 2 0 4 4 4 2 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO26799.1 - 0.1 12.7 8.1 1.3 9.2 0.2 4.7 2 2 3 5 5 5 0 RNA 2'-O ribose methyltransferase substrate binding CbiG_N PF11760.3 KOO26799.1 - 0.99 9.1 17.9 6.4 6.5 0.1 6.4 5 1 2 7 7 7 0 Cobalamin synthesis G N-terminal LRR_7 PF13504.1 KOO26799.1 - 1.8 9.1 15.2 76 4.2 0.1 7.9 9 0 0 9 9 9 0 Leucine rich repeat DUF4033 PF13225.1 KOO26800.1 - 3.7e-12 45.6 0.3 6e-12 45.0 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4033) Ank_2 PF12796.2 KOO26801.1 - 2.9e-09 37.1 2.1 8.7e-06 25.9 0.8 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) 2OG-FeII_Oxy_3 PF13640.1 KOO26801.1 - 1.3e-08 35.2 0.0 3.6e-08 33.8 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ank PF00023.25 KOO26801.1 - 5.5e-06 25.9 2.5 0.14 12.0 0.3 3.5 2 1 1 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 KOO26801.1 - 0.00028 21.0 5.3 1.3 9.3 0.2 4.3 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO26801.1 - 0.00043 20.7 1.2 3 8.4 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO26801.1 - 0.0021 18.1 0.5 19 5.8 0.0 4.0 3 0 0 3 3 3 1 Ankyrin repeat zf-RanBP PF00641.13 KOO26801.1 - 0.033 13.2 6.4 0.039 13.0 1.8 2.7 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Cupin_8 PF13621.1 KOO26802.1 - 2e-45 155.2 0.0 3.3e-45 154.5 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 KOO26802.1 - 9.4e-05 21.8 0.5 0.0088 15.3 0.0 3.3 4 0 0 4 4 4 1 Cupin superfamily protein DUF4058 PF13267.1 KOO26802.1 - 0.3 10.1 0.0 0.53 9.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4058) Hint PF01079.15 KOO26803.1 - 8e-13 48.0 0.3 1.7e-12 47.0 0.0 1.6 2 0 0 2 2 2 1 Hint module Pyridox_ox_2 PF12900.2 KOO26803.1 - 0.011 15.5 0.8 1.1 9.1 0.1 2.8 2 1 1 3 3 3 0 Pyridoxamine 5'-phosphate oxidase Rsc14 PF08586.5 KOO26803.1 - 0.086 13.3 0.0 8.7 6.8 0.0 2.5 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit Exostosin PF03016.10 KOO26804.1 - 0.0073 15.3 0.0 0.014 14.4 0.0 1.4 1 0 0 1 1 1 1 Exostosin family Pyr_redox_2 PF07992.9 KOO26805.1 - 6.2e-27 94.7 2.3 7.5e-27 94.5 0.5 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thioredoxin PF00085.15 KOO26805.1 - 6.2e-15 54.7 0.6 3.4e-14 52.3 0.1 2.5 3 0 0 3 3 2 1 Thioredoxin Pyr_redox_3 PF13738.1 KOO26805.1 - 2.8e-13 50.4 5.3 4e-07 30.3 0.0 3.2 1 1 2 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 KOO26805.1 - 9.6e-06 24.9 1.0 9.6e-06 24.9 0.7 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.9 KOO26805.1 - 6.8e-05 21.5 2.9 0.021 13.3 1.7 2.7 2 0 0 2 2 2 2 HI0933-like protein NAD_binding_7 PF13241.1 KOO26805.1 - 7.7e-05 22.8 1.8 0.91 9.8 0.0 3.7 3 1 1 4 4 4 2 Putative NAD(P)-binding DAO PF01266.19 KOO26805.1 - 0.00018 20.5 4.9 0.016 14.1 0.6 2.9 1 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.22 KOO26805.1 - 0.00027 21.2 10.8 0.14 12.5 0.2 4.2 4 1 1 5 5 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 KOO26805.1 - 0.00028 19.8 7.2 0.00044 19.2 1.4 2.9 2 1 1 3 3 3 1 FAD binding domain GIDA PF01134.17 KOO26805.1 - 0.00029 19.8 4.5 0.0011 17.9 0.6 3.1 3 0 0 3 3 3 1 Glucose inhibited division protein A Thioredoxin_4 PF13462.1 KOO26805.1 - 0.00043 20.3 1.4 0.0028 17.6 0.2 2.4 2 1 0 2 2 2 1 Thioredoxin NAD_binding_8 PF13450.1 KOO26805.1 - 0.00098 19.0 0.2 0.0033 17.4 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 KOO26805.1 - 0.0011 18.0 4.9 0.0025 16.9 0.5 2.6 2 1 0 2 2 2 1 Thi4 family Thioredoxin_8 PF13905.1 KOO26805.1 - 0.0013 18.8 0.0 0.0039 17.2 0.0 1.9 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 KOO26805.1 - 0.013 15.6 0.9 0.035 14.3 0.6 2.0 1 1 0 1 1 1 0 Thioredoxin-like domain Redoxin PF08534.5 KOO26805.1 - 0.015 14.8 0.0 0.033 13.7 0.0 1.6 1 0 0 1 1 1 0 Redoxin Armet PF10208.4 KOO26805.1 - 0.062 12.9 2.5 0.11 12.0 0.1 2.3 2 0 0 2 2 2 0 Degradation arginine-rich protein for mis-folding FAD_binding_3 PF01494.14 KOO26805.1 - 0.15 11.0 3.8 0.18 10.7 0.6 2.4 3 0 0 3 3 3 0 FAD binding domain DWNN PF08783.6 KOO26805.1 - 0.24 11.3 1.4 0.42 10.5 0.4 1.7 2 0 0 2 2 2 0 DWNN domain K_oxygenase PF13434.1 KOO26805.1 - 0.33 9.8 2.2 0.33 9.8 0.0 2.1 3 0 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) AAA PF00004.24 KOO26807.1 - 4.3e-22 78.7 0.2 1.2e-21 77.3 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) LRR_6 PF13516.1 KOO26807.1 - 1.6e-07 30.6 2.8 0.25 11.5 0.2 4.8 4 0 0 4 4 4 2 Leucine Rich repeat AAA_17 PF13207.1 KOO26807.1 - 8.9e-05 23.2 0.0 0.00024 21.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 KOO26807.1 - 0.00091 18.9 0.0 0.0021 17.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 KOO26807.1 - 0.01 14.9 0.0 0.096 11.7 0.0 2.3 2 1 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 KOO26807.1 - 0.018 14.9 0.0 0.035 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 KOO26807.1 - 0.023 14.8 0.7 0.82 9.8 0.5 2.7 1 1 0 1 1 1 0 AAA domain LRR_4 PF12799.2 KOO26807.1 - 0.032 13.8 0.0 0.12 12.0 0.0 1.9 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) AAA_28 PF13521.1 KOO26807.1 - 0.04 13.8 0.4 0.098 12.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.1 KOO26807.1 - 0.099 12.2 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain Cas_Csy3 PF09615.5 KOO26807.1 - 0.24 10.4 0.3 1.5 7.8 0.0 2.0 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csy3) SR-25 PF10500.4 KOO26807.1 - 1.6 8.1 4.2 3.4 7.0 2.9 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pyr_redox_3 PF13738.1 KOO26808.1 - 9.2e-05 22.5 0.0 0.00021 21.4 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Hexapep PF00132.19 KOO26808.1 - 0.001 18.4 2.3 0.0024 17.3 1.6 1.6 1 0 0 1 1 1 1 Bacterial transferase hexapeptide (six repeats) K_oxygenase PF13434.1 KOO26808.1 - 0.014 14.3 0.0 0.023 13.6 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Acetyltransf_2 PF00797.12 KOO26809.1 - 1.7e-56 191.5 0.0 2e-56 191.2 0.0 1.0 1 0 0 1 1 1 1 N-acetyltransferase Viral_Rep PF02407.11 KOO26810.1 - 0.026 14.5 0.4 0.057 13.4 0.0 1.7 2 0 0 2 2 2 0 Putative viral replication protein DUF1295 PF06966.7 KOO26811.1 - 3.8e-43 147.4 0.7 4.5e-43 147.2 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.9 KOO26811.1 - 0.0022 18.1 0.3 0.0039 17.3 0.2 1.6 1 1 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 KOO26811.1 - 0.0069 16.4 0.3 0.014 15.4 0.2 1.6 1 0 0 1 1 1 1 Phospholipid methyltransferase ERG4_ERG24 PF01222.12 KOO26811.1 - 0.026 13.0 1.6 0.041 12.4 1.1 1.3 1 1 0 1 1 1 0 Ergosterol biosynthesis ERG4/ERG24 family UvrD-helicase PF00580.16 KOO26812.1 - 8.3e-10 38.4 0.0 1.3e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.13 KOO26812.1 - 0.0037 16.8 0.0 1.3 8.4 0.0 2.6 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Acyltransferase PF01553.16 KOO26814.1 - 3.2e-11 42.8 0.0 4.9e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase DAGAT PF03982.8 KOO26814.1 - 6.3e-08 31.6 0.6 1e-06 27.6 0.4 2.1 1 1 0 1 1 1 1 Diacylglycerol acyltransferase Peptidase_A22B PF04258.8 KOO26815.1 - 2.1e-53 181.7 7.5 3.5e-53 181.0 5.2 1.3 1 0 0 1 1 1 1 Signal peptide peptidase Exostosin PF03016.10 KOO26816.1 - 4.1e-14 52.3 0.0 7.5e-14 51.4 0.0 1.5 1 1 0 1 1 1 1 Exostosin family Cpn10 PF00166.16 KOO26817.1 - 4.9e-42 141.7 0.5 1.4e-20 73.0 0.1 2.1 2 0 0 2 2 2 2 Chaperonin 10 Kd subunit TRAM PF01938.15 KOO26817.1 - 0.099 12.4 0.4 0.27 11.0 0.1 2.0 2 0 0 2 2 2 0 TRAM domain SHIPPO-rpt PF07004.7 KOO26821.1 - 0.0051 17.6 6.3 0.53 11.2 1.3 2.9 2 2 0 2 2 2 2 Sperm-tail PG-rich repeat Methyltransf_21 PF05050.7 KOO26824.1 - 7.2e-05 22.8 0.0 0.00037 20.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase FkbM domain BAF1_ABF1 PF04684.8 KOO26826.1 - 0.0077 15.1 0.2 0.0098 14.7 0.1 1.2 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor PCIF1_WW PF12237.3 KOO26827.1 - 3.7e-36 124.0 0.1 9.4e-36 122.7 0.0 1.7 1 0 0 1 1 1 1 Phosphorylated CTD interacting factor 1 WW domain TBCC PF07986.7 KOO26828.1 - 4e-23 81.1 1.9 5e-23 80.7 1.3 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.6 KOO26828.1 - 0.0041 16.4 6.8 0.0068 15.7 4.7 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal ATP-synt_ab PF00006.20 KOO26830.1 - 4.6e-61 206.0 0.0 7.3e-61 205.4 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 KOO26830.1 - 5.1e-25 88.1 0.1 9.8e-25 87.2 0.0 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 KOO26830.1 - 7.4e-23 80.5 3.3 1.5e-22 79.5 2.3 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain KaiC PF06745.8 KOO26830.1 - 0.0047 16.0 0.2 0.0087 15.2 0.1 1.5 1 0 0 1 1 1 1 KaiC MobB PF03205.9 KOO26830.1 - 0.052 13.2 0.2 7.8 6.2 0.0 3.1 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.1 KOO26830.1 - 0.064 12.6 0.1 0.14 11.5 0.1 1.6 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.17 KOO26830.1 - 0.44 9.3 1.2 0.5 9.1 0.1 1.5 2 0 0 2 2 2 0 NB-ARC domain Methyltransf_16 PF10294.4 KOO26831.1 - 1.3e-18 67.0 0.0 2.1e-18 66.3 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase EF-hand_7 PF13499.1 KOO26831.1 - 2.3e-08 34.0 0.0 9.2e-08 32.1 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain pair MTS PF05175.9 KOO26831.1 - 5.2e-08 32.4 0.0 1.2e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.2 KOO26831.1 - 1.8e-07 31.6 0.0 5.1e-07 30.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO26831.1 - 2.6e-07 30.6 0.0 5.6e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 KOO26831.1 - 1.1e-06 27.9 0.0 2.3e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.1 KOO26831.1 - 1.2e-06 28.1 0.0 1.9e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain EF-hand_6 PF13405.1 KOO26831.1 - 1.1e-05 24.9 0.7 0.0014 18.3 0.0 3.1 2 1 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 KOO26831.1 - 2.1e-05 23.4 0.0 0.0021 17.2 0.0 2.9 2 0 0 2 2 2 1 EF hand EF-hand_9 PF14658.1 KOO26831.1 - 0.0011 18.7 0.0 0.0019 18.0 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.1 KOO26831.1 - 0.015 14.9 0.8 0.54 9.9 0.0 3.1 1 1 2 3 3 3 0 EF-hand domain pair Methyltransf_12 PF08242.7 KOO26831.1 - 0.017 15.6 0.0 0.045 14.2 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.1 KOO26831.1 - 0.04 14.2 0.0 0.09 13.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 KOO26831.1 - 0.058 13.1 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain NNMT_PNMT_TEMT PF01234.12 KOO26831.1 - 0.07 12.0 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Na_Ca_ex PF01699.19 KOO26832.1 - 5.9e-37 126.3 29.0 1.2e-20 73.4 7.0 3.0 2 2 0 2 2 2 2 Sodium/calcium exchanger protein PIH1 PF08190.7 KOO26833.1 - 1.2e-53 182.6 0.0 1.2e-53 182.6 0.0 3.5 3 1 0 3 3 3 1 pre-RNA processing PIH1/Nop17 DUF940 PF06082.6 KOO26833.1 - 0.43 9.0 3.6 0.72 8.3 2.5 1.3 1 0 0 1 1 1 0 Bacterial putative lipoprotein (DUF940) Aa_trans PF01490.13 KOO26834.1 - 2.3e-39 135.0 19.8 3.1e-39 134.6 13.7 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein UQ_con PF00179.21 KOO26835.1 - 4.7e-37 126.5 0.1 5e-37 126.4 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KOO26835.1 - 2.2e-06 27.4 0.0 2.7e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.8 KOO26835.1 - 0.0017 18.0 0.1 0.0022 17.6 0.0 1.2 1 0 0 1 1 1 1 UEV domain RWD PF05773.17 KOO26835.1 - 0.11 12.3 0.3 0.15 11.9 0.2 1.5 1 1 0 1 1 1 0 RWD domain DUF1538 PF07556.6 KOO26837.1 - 5.6e-87 290.2 31.0 2.8e-46 157.2 10.7 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1538) RRM_1 PF00076.17 KOO26839.1 - 6.9e-12 44.8 0.0 0.00016 21.2 0.1 3.1 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO26839.1 - 2e-11 43.6 0.0 2.1e-05 24.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO26839.1 - 2.7e-07 30.3 0.0 1.2e-05 24.9 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4339 PF14237.1 KOO26839.1 - 0.0099 15.4 0.2 0.02 14.4 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4339) EF-hand_1 PF00036.27 KOO26841.1 - 6.6e-12 43.8 4.5 1.8e-05 23.6 0.0 4.5 5 0 0 5 5 5 2 EF hand EF-hand_6 PF13405.1 KOO26841.1 - 4.1e-11 41.7 0.8 0.00083 19.0 0.0 4.6 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.1 KOO26841.1 - 5.7e-11 42.3 1.7 1.2e-09 38.1 0.1 3.5 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO26841.1 - 2.9e-08 33.2 5.8 0.0005 19.6 0.0 4.6 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO26841.1 - 2.1e-07 29.9 0.6 0.014 14.7 0.1 3.0 2 0 0 2 2 2 2 EF hand TPR_11 PF13414.1 KOO26841.1 - 1.3e-05 24.7 0.7 3.8e-05 23.2 0.5 1.9 1 0 0 1 1 1 1 TPR repeat fn3 PF00041.16 KOO26841.1 - 0.00016 21.7 0.1 0.00033 20.7 0.1 1.6 1 0 0 1 1 1 1 Fibronectin type III domain TPR_16 PF13432.1 KOO26841.1 - 0.0088 16.6 0.5 0.0088 16.6 0.3 3.5 1 1 3 4 4 4 2 Tetratricopeptide repeat BCNT PF07572.7 KOO26843.1 - 3e-17 62.3 1.4 5.5e-17 61.4 1.0 1.4 1 0 0 1 1 1 1 Bucentaur or craniofacial development zf-met PF12874.2 KOO26843.1 - 0.044 13.9 0.1 0.077 13.2 0.1 1.4 1 0 0 1 1 1 0 Zinc-finger of C2H2 type IncA PF04156.9 KOO26843.1 - 0.3 10.6 1.6 3.6 7.1 0.3 2.4 2 0 0 2 2 2 0 IncA protein CCDC155 PF14662.1 KOO26846.1 - 0.01 15.4 11.6 0.01 15.4 8.0 1.9 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 GldM_N PF12081.3 KOO26846.1 - 0.014 14.9 1.4 0.022 14.2 1.0 1.3 1 0 0 1 1 1 0 GldM N-terminal domain Acyl_transf_1 PF00698.16 KOO26846.1 - 0.019 14.3 3.5 0.024 13.9 2.5 1.1 1 0 0 1 1 1 0 Acyl transferase domain DUF972 PF06156.8 KOO26846.1 - 0.024 14.9 8.5 0.06 13.6 1.0 2.6 1 1 1 3 3 3 0 Protein of unknown function (DUF972) CENP-F_leu_zip PF10473.4 KOO26846.1 - 0.22 11.3 14.8 3.1 7.6 0.2 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4140 PF13600.1 KOO26846.1 - 0.54 10.7 0.0 0.54 10.7 0.0 3.6 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Jnk-SapK_ap_N PF09744.4 KOO26846.1 - 1.7 8.6 6.6 0.31 10.9 2.0 1.7 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Cluap1 PF10234.4 KOO26846.1 - 1.7 7.7 9.7 6.5 5.8 3.7 2.2 1 1 1 2 2 2 0 Clusterin-associated protein-1 V_ATPase_I PF01496.14 KOO26846.1 - 2 6.1 3.6 8 4.1 0.4 1.9 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family DUF4201 PF13870.1 KOO26846.1 - 4.4 6.6 11.9 1.9 7.8 3.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) DUF4407 PF14362.1 KOO26846.1 - 5.6 5.8 19.6 11 4.8 13.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) WD40 PF00400.27 KOO26847.1 - 3.7e-54 178.7 18.3 6.4e-13 48.0 0.4 5.2 5 0 0 5 5 5 5 WD domain, G-beta repeat PD40 PF07676.7 KOO26847.1 - 2.3e-09 36.7 4.2 1 9.0 0.0 5.4 5 0 0 5 5 5 3 WD40-like Beta Propeller Repeat BBS2_Mid PF14783.1 KOO26847.1 - 5.7e-08 32.5 0.2 0.00022 20.9 0.1 3.3 2 1 1 3 3 3 2 Ciliary BBSome complex subunit 2, middle region eIF2A PF08662.6 KOO26847.1 - 9.7e-08 31.9 1.2 0.00038 20.2 0.3 2.9 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A DUF3312 PF11768.3 KOO26847.1 - 2.9e-05 22.5 0.0 0.24 9.6 0.0 3.0 1 1 2 3 3 3 2 Protein of unknown function (DUF3312) LigD_N PF13298.1 KOO26847.1 - 4.5e-05 23.4 2.2 0.67 10.0 0.0 4.6 1 1 4 5 5 5 1 DNA polymerase Ligase (LigD) Nbas_N PF15492.1 KOO26847.1 - 4.8e-05 22.5 5.2 1.7 7.6 0.1 4.2 1 1 3 4 4 4 4 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.11 KOO26847.1 - 0.00026 19.4 0.3 0.002 16.5 0.0 2.2 1 1 1 2 2 2 1 Cytochrome D1 heme domain DUF3892 PF13031.1 KOO26847.1 - 0.004 17.5 0.5 3.4 8.1 0.1 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF3892) DUF3255 PF11631.3 KOO26847.1 - 0.051 13.1 0.2 76 2.9 0.0 4.1 2 1 2 4 4 4 0 Protein of unknown function (DUF3255) Phosphoesterase PF04185.9 KOO26848.1 - 1.8e-50 172.2 0.0 3.5e-50 171.2 0.0 1.6 1 1 0 1 1 1 1 Phosphoesterase family Arm PF00514.18 KOO26849.1 - 2.4e-14 52.5 7.8 0.00046 19.8 0.0 4.1 4 0 0 4 4 4 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO26849.1 - 1.4e-05 25.3 14.7 0.0031 17.7 4.7 2.3 1 1 1 2 2 2 2 HEAT repeats HEAT PF02985.17 KOO26849.1 - 0.0023 17.8 3.6 4.1 7.7 0.0 3.9 3 1 1 4 4 4 1 HEAT repeat HEAT_EZ PF13513.1 KOO26849.1 - 0.12 12.9 0.7 0.12 12.9 0.5 3.2 2 1 1 3 3 3 0 HEAT-like repeat Succ_CoA_lig PF13607.1 KOO26849.1 - 8.3 6.0 11.9 2.6 7.6 3.4 2.2 1 1 1 2 2 2 0 Succinyl-CoA ligase like flavodoxin domain Aha1_N PF09229.6 KOO26850.1 - 1.8e-16 60.2 0.2 2.8e-16 59.5 0.2 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal PDZ_2 PF13180.1 KOO26850.1 - 0.00013 21.8 0.0 0.00024 20.9 0.0 1.4 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.9 KOO26850.1 - 0.0016 18.4 0.0 0.0027 17.6 0.0 1.3 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain LRR_6 PF13516.1 KOO26850.1 - 0.01 15.8 0.1 3.3 8.0 0.0 3.0 3 0 0 3 3 3 0 Leucine Rich repeat Ribosomal_60s PF00428.14 KOO26850.1 - 4.9 7.6 9.7 28 5.1 6.7 2.3 1 1 0 1 1 1 0 60s Acidic ribosomal protein Amidohydro_2 PF04909.9 KOO26852.1 - 2.8e-19 69.7 0.3 5.3e-19 68.8 0.2 1.5 1 0 0 1 1 1 1 Amidohydrolase TPR_11 PF13414.1 KOO26854.1 - 1.5e-21 75.8 2.9 1.6e-10 40.4 0.2 2.5 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 KOO26854.1 - 3.3e-20 70.7 0.2 4.6e-05 22.8 0.3 4.3 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.12 KOO26854.1 - 6.8e-19 66.2 2.1 0.00011 21.8 0.4 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.1 KOO26854.1 - 8.4e-10 38.0 3.1 0.049 13.8 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO26854.1 - 1.9e-09 37.9 14.0 8.9e-06 26.2 1.1 3.2 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO26854.1 - 2.1e-08 34.0 2.8 0.0013 18.5 0.1 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO26854.1 - 4.1e-08 32.9 17.1 0.0026 17.5 0.9 3.4 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOO26854.1 - 8.7e-06 25.9 17.3 0.0055 17.2 0.7 5.5 3 1 3 6 6 5 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO26854.1 - 2.9e-05 23.5 0.0 0.053 13.3 0.0 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat PH PF00169.24 KOO26854.1 - 0.00051 20.1 0.0 0.0013 18.9 0.0 1.6 1 1 0 1 1 1 1 PH domain TPR_7 PF13176.1 KOO26854.1 - 0.0061 16.2 2.7 3.3 7.7 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat UAA PF08449.6 KOO26855.1 - 2.6e-71 240.0 17.1 3.1e-71 239.7 11.9 1.0 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 KOO26855.1 - 7e-06 25.7 12.6 7e-06 25.7 8.8 2.4 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 KOO26855.1 - 1.1e-05 25.4 25.3 0.0057 16.6 9.1 2.8 2 1 1 3 3 3 2 EamA-like transporter family Pro_isomerase PF00160.16 KOO26856.1 - 8.9e-13 48.7 0.0 1.4e-12 48.1 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Zn_Tnp_IS91 PF14319.1 KOO26857.1 - 0.088 12.3 1.3 0.27 10.7 0.1 1.9 2 0 0 2 2 2 0 Transposase zinc-binding domain LLC1 PF14945.1 KOO26858.1 - 0.00043 20.5 0.8 0.0015 18.8 0.2 2.0 2 0 0 2 2 2 1 Normal lung function maintenance, Low in Lung Cancer 1 protein FAM183 PF14886.1 KOO26858.1 - 0.0076 16.7 0.0 0.015 15.8 0.0 1.5 1 0 0 1 1 1 1 FAM183A and FAM183B related DUF591 PF04569.9 KOO26858.1 - 0.03 14.3 0.1 0.062 13.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function PAE PF03283.8 KOO26860.1 - 2.1e-41 141.7 0.0 2.9e-41 141.3 0.0 1.1 1 0 0 1 1 1 1 Pectinacetylesterase zf-C3HC4_3 PF13920.1 KOO26861.1 - 3.9e-11 42.4 9.9 5.4e-11 41.9 6.9 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO26861.1 - 0.0021 18.0 11.1 0.0033 17.4 7.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO26861.1 - 0.037 13.7 9.6 0.071 12.8 6.7 1.5 1 1 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.1 KOO26861.1 - 0.41 10.2 8.5 0.72 9.4 5.9 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_2 PF13639.1 KOO26861.1 - 0.47 10.3 9.7 0.81 9.5 6.7 1.4 1 0 0 1 1 1 0 Ring finger domain Pkinase PF00069.20 KOO26862.1 - 1.4e-35 122.7 0.0 2.7e-35 121.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO26862.1 - 1.9e-32 112.3 0.0 3.2e-32 111.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase LRR_8 PF13855.1 KOO26862.1 - 2.8e-05 23.7 0.2 7.3e-05 22.4 0.1 1.7 1 0 0 1 1 1 1 Leucine rich repeat RRM_1 PF00076.17 KOO26862.1 - 0.0021 17.6 0.0 0.029 13.9 0.0 2.9 4 0 0 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Kinase-like PF14531.1 KOO26862.1 - 0.0028 16.6 0.0 0.0049 15.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like LRR_4 PF12799.2 KOO26862.1 - 0.01 15.4 0.1 0.045 13.3 0.0 2.0 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) RRM_6 PF14259.1 KOO26862.1 - 0.012 15.5 0.1 0.12 12.4 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF4054 PF13262.1 KOO26862.1 - 0.012 15.8 0.2 0.31 11.3 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4054) Cellulase-like PF12876.2 KOO26862.1 - 0.038 14.4 0.1 0.16 12.4 0.0 2.1 2 0 0 2 2 2 0 Sugar-binding cellulase-like LRR_1 PF00560.28 KOO26862.1 - 0.052 13.5 0.3 0.3 11.2 0.0 2.5 2 0 0 2 2 2 0 Leucine Rich Repeat RRM_5 PF13893.1 KOO26862.1 - 0.055 13.3 0.2 0.39 10.6 0.0 2.7 4 0 0 4 4 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LRR_6 PF13516.1 KOO26862.1 - 0.059 13.4 0.1 2.2 8.5 0.0 3.2 3 0 0 3 3 3 0 Leucine Rich repeat Glyco_trans_1_3 PF13528.1 KOO26862.1 - 0.076 12.1 0.1 0.19 10.9 0.0 1.6 2 0 0 2 2 2 0 Glycosyl transferase family 1 PCI PF01399.22 KOO26863.1 - 4.9e-15 55.7 0.0 1e-14 54.7 0.0 1.6 1 0 0 1 1 1 1 PCI domain PIF1 PF05970.9 KOO26864.1 - 2.5e-26 92.4 0.1 2.4e-24 85.9 0.1 2.8 3 0 0 3 3 3 1 PIF1-like helicase AAA_30 PF13604.1 KOO26864.1 - 2.7e-15 56.4 1.4 2e-09 37.3 0.1 3.5 3 0 0 3 3 3 2 AAA domain RRM_3 PF08777.6 KOO26864.1 - 3.6e-08 33.1 0.0 1e-07 31.7 0.0 1.7 2 0 0 2 2 1 1 RNA binding motif AAA_19 PF13245.1 KOO26864.1 - 1.7e-06 27.6 1.4 7e-06 25.7 1.0 2.1 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 KOO26864.1 - 3.3e-06 27.2 0.1 1.2e-05 25.4 0.0 2.0 2 1 1 3 3 2 1 AAA domain RRM_5 PF13893.1 KOO26864.1 - 0.0002 21.1 0.0 0.00052 19.8 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mg_chelatase PF01078.16 KOO26864.1 - 0.0002 20.5 0.1 0.00038 19.6 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RRM_1 PF00076.17 KOO26864.1 - 0.00022 20.7 0.0 0.00048 19.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO26864.1 - 0.00068 19.5 0.0 0.0015 18.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) AAA_5 PF07728.9 KOO26864.1 - 0.0018 18.0 0.0 0.0081 15.8 0.0 2.1 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) UvrD-helicase PF00580.16 KOO26864.1 - 0.0026 17.1 0.2 0.0057 16.0 0.1 1.5 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_16 PF13191.1 KOO26864.1 - 0.01 15.8 3.9 0.013 15.4 1.3 2.4 1 1 1 2 2 2 0 AAA ATPase domain AAA_14 PF13173.1 KOO26864.1 - 0.014 15.3 0.0 0.079 12.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.1 KOO26864.1 - 0.018 14.5 0.1 0.04 13.4 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Helicase_RecD PF05127.9 KOO26864.1 - 0.025 14.2 3.7 0.12 12.0 1.3 2.6 2 1 0 2 2 2 0 Helicase AAA_25 PF13481.1 KOO26864.1 - 0.033 13.6 3.0 0.078 12.3 0.9 2.3 2 1 0 2 2 2 0 AAA domain AAA_10 PF12846.2 KOO26864.1 - 0.062 12.7 0.5 0.13 11.6 0.1 1.7 2 0 0 2 2 2 0 AAA-like domain NTPase_1 PF03266.10 KOO26864.1 - 0.087 12.5 2.4 0.41 10.3 0.4 2.7 2 1 0 2 2 2 0 NTPase Viral_helicase1 PF01443.13 KOO26864.1 - 0.093 12.2 0.4 0.58 9.6 0.3 2.1 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.17 KOO26864.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase DEAD PF00270.24 KOO26864.1 - 0.13 11.6 0.1 11 5.4 0.1 2.2 1 1 0 2 2 2 0 DEAD/DEAH box helicase AAA_11 PF13086.1 KOO26864.1 - 0.34 10.4 2.9 0.94 9.0 0.0 2.8 4 0 0 4 4 4 0 AAA domain DUF1793 PF08760.6 KOO26865.1 - 3.1e-43 147.5 0.2 5e-43 146.9 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) PAN_4 PF14295.1 KOO26865.1 - 0.00047 19.8 2.7 0.0013 18.4 1.8 1.8 1 0 0 1 1 1 1 PAN domain PAN_1 PF00024.21 KOO26865.1 - 0.011 15.4 1.6 0.035 13.8 1.1 1.8 1 0 0 1 1 1 0 PAN domain Peptidase_M50B PF13398.1 KOO26866.1 - 0.019 14.3 0.1 0.037 13.4 0.0 1.4 1 0 0 1 1 1 0 Peptidase M50B-like Lipocalin_2 PF08212.7 KOO26867.1 - 2.3e-08 33.9 0.0 0.0037 17.0 0.0 2.2 2 0 0 2 2 2 2 Lipocalin-like domain Lipocalin PF00061.18 KOO26867.1 - 0.1 12.5 0.0 0.44 10.5 0.0 1.8 2 0 0 2 2 2 0 Lipocalin / cytosolic fatty-acid binding protein family FGGY_C PF02782.11 KOO26868.1 - 1.6e-20 73.5 2.2 1.6e-20 73.5 1.5 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 KOO26868.1 - 8.7e-20 71.0 0.0 3.8e-16 59.1 0.0 2.7 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain LRR_6 PF13516.1 KOO26870.1 - 2.8e-09 36.0 21.0 0.35 11.0 0.0 10.1 11 0 0 11 11 11 2 Leucine Rich repeat LRR_1 PF00560.28 KOO26870.1 - 4e-09 35.2 3.1 9.2 6.7 0.0 7.1 7 0 0 7 7 7 2 Leucine Rich Repeat LRR_4 PF12799.2 KOO26870.1 - 1.3e-06 27.8 3.1 1.2 8.8 0.0 6.2 6 0 0 6 6 6 1 Leucine Rich repeats (2 copies) TrkA_C PF02080.16 KOO26870.1 - 0.0018 17.8 0.0 5.2 6.7 0.0 4.5 4 0 0 4 4 4 1 TrkA-C domain FIBP PF05427.6 KOO26870.1 - 0.0034 16.6 0.2 20 4.2 0.0 3.7 4 0 0 4 4 4 0 Acidic fibroblast growth factor binding (FIBP) THF_DHG_CYH_C PF02882.14 KOO26870.1 - 0.0062 15.6 0.1 0.92 8.5 0.0 3.0 3 0 0 3 3 3 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain PhoH PF02562.11 KOO26870.1 - 0.0071 15.6 0.1 12 5.0 0.0 4.0 4 0 0 4 4 4 1 PhoH-like protein SpoU_sub_bind PF08032.7 KOO26870.1 - 0.015 15.4 2.2 46 4.2 0.0 4.9 5 1 1 6 6 6 0 RNA 2'-O ribose methyltransferase substrate binding DUF902 PF06001.8 KOO26870.1 - 0.016 15.3 3.1 1.3e+02 2.8 0.0 5.1 5 0 0 5 5 5 0 Domain of Unknown Function (DUF902) LRR_7 PF13504.1 KOO26870.1 - 0.024 14.7 6.7 2.7e+02 2.5 0.0 7.3 7 0 0 7 7 7 0 Leucine rich repeat Na_Ca_ex PF01699.19 KOO26870.1 - 0.079 12.5 0.4 22 4.6 0.0 3.6 3 0 0 3 3 3 0 Sodium/calcium exchanger protein DUF1942 PF09167.6 KOO26870.1 - 0.083 12.6 0.9 19 5.0 0.0 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF1942) PfkB PF00294.19 KOO26873.1 - 6.8e-56 189.6 0.4 8.6e-56 189.2 0.3 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase DUF1491 PF07372.7 KOO26873.1 - 0.18 11.6 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1491) TrwC PF08751.6 KOO26874.1 - 0.072 12.5 0.2 0.17 11.2 0.1 1.6 1 1 1 2 2 2 0 TrwC relaxase DUF4057 PF13266.1 KOO26875.1 - 5.2 6.4 8.8 17 4.7 0.0 4.6 6 0 0 6 6 6 0 Protein of unknown function (DUF4057) Remorin_N PF03766.8 KOO26875.1 - 7.5 6.4 6.9 5 6.9 0.3 3.2 3 1 0 3 3 3 0 Remorin, N-terminal region PCMT PF01135.14 KOO26876.1 - 3.1e-28 98.7 0.0 5.5e-28 97.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ank_2 PF12796.2 KOO26876.1 - 1.2e-26 92.8 13.6 6.4e-12 45.6 1.5 2.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO26876.1 - 5.5e-20 70.0 11.2 0.00014 21.5 0.1 5.7 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.1 KOO26876.1 - 2.2e-17 62.6 11.3 1.2e-07 31.7 1.0 4.7 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO26876.1 - 9.3e-17 61.0 3.9 8.8e-09 35.6 0.0 3.7 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO26876.1 - 3.8e-10 38.9 5.2 0.043 14.0 0.0 5.7 5 0 0 5 5 5 3 Ankyrin repeat TIR_2 PF13676.1 KOO26876.1 - 2.2e-09 37.3 0.0 6.9e-09 35.7 0.0 1.8 1 0 0 1 1 1 1 TIR domain Methyltransf_31 PF13847.1 KOO26876.1 - 3.1e-08 33.3 0.0 8.2e-08 31.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO26876.1 - 2.8e-05 24.6 0.0 0.00013 22.5 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain C1_2 PF03107.11 KOO26876.1 - 0.00082 19.4 12.7 0.0017 18.4 8.8 1.6 1 0 0 1 1 1 1 C1 domain MTS PF05175.9 KOO26876.1 - 0.00085 18.7 0.0 0.0037 16.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain C1_3 PF07649.7 KOO26876.1 - 0.0013 18.7 12.1 0.0029 17.5 8.4 1.7 1 0 0 1 1 1 1 C1-like domain Methyltransf_32 PF13679.1 KOO26876.1 - 0.0014 18.3 0.1 0.0092 15.6 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain HC2 PF07382.6 KOO26876.1 - 0.0079 16.0 13.5 0.016 15.1 9.4 1.4 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 FYVE PF01363.16 KOO26876.1 - 0.0085 15.9 2.1 0.018 14.9 1.4 1.5 1 0 0 1 1 1 1 FYVE zinc finger DOT1 PF08123.8 KOO26876.1 - 0.043 13.1 0.0 0.075 12.3 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_11 PF08241.7 KOO26876.1 - 0.057 13.9 0.0 0.2 12.1 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.15 KOO26876.1 - 0.18 10.8 0.0 0.31 10.0 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase zf-C2H2_6 PF13912.1 KOO26876.1 - 5.1 7.1 7.6 0.77 9.7 0.1 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger SIR2 PF02146.12 KOO26878.1 - 8e-32 110.3 0.0 1.7e-22 79.9 0.0 2.1 2 0 0 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.17 KOO26878.1 - 0.017 14.9 0.0 3.8 7.2 0.0 2.7 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain zf-TFIIB PF13453.1 KOO26878.1 - 0.61 9.3 2.7 2.3 7.4 1.9 1.9 1 1 0 1 1 1 0 Transcription factor zinc-finger Peptidase_C2 PF00648.16 KOO26879.1 - 4.8e-12 45.4 0.0 8.5e-12 44.6 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Rifin_STEVOR PF02009.11 KOO26879.1 - 1.8 8.1 2.2 2.7 7.5 1.5 1.2 1 0 0 1 1 1 0 Rifin/stevor family ADK PF00406.17 KOO26880.1 - 1.3e-54 184.1 0.0 1.6e-54 183.9 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 KOO26880.1 - 8.9e-11 41.2 0.0 7.9e-09 35.0 0.0 2.5 1 1 0 1 1 1 1 Adenylate kinase, active site lid Zeta_toxin PF06414.7 KOO26880.1 - 2e-05 23.8 0.0 3.5e-05 22.9 0.0 1.4 1 1 0 1 1 1 1 Zeta toxin AAA_33 PF13671.1 KOO26880.1 - 3.2e-05 23.8 0.0 5.3e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO26880.1 - 3.9e-05 24.4 0.0 6.3e-05 23.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOO26880.1 - 0.0085 16.4 0.0 0.038 14.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 KOO26880.1 - 0.074 13.2 0.1 0.13 12.5 0.1 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.16 KOO26880.1 - 0.14 11.3 0.4 0.19 10.8 0.3 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Kelch_6 PF13964.1 KOO26881.1 - 5e-11 42.2 0.0 0.5 10.6 0.0 6.5 6 0 0 6 6 6 4 Kelch motif Ribosomal_L11_N PF03946.9 KOO26881.1 - 6.4e-05 22.3 20.7 9.8 5.7 0.1 7.2 7 0 0 7 7 7 6 Ribosomal protein L11, N-terminal domain SGL PF08450.7 KOO26881.1 - 0.00013 21.4 0.0 2.3 7.5 0.0 4.7 2 2 1 5 5 5 1 SMP-30/Gluconolaconase/LRE-like region CH PF00307.26 KOO26882.1 - 1.4e-22 79.7 0.0 9.5e-10 38.4 0.0 2.8 2 0 0 2 2 2 2 Calponin homology (CH) domain EF-hand_1 PF00036.27 KOO26882.1 - 2.4e-14 51.4 1.1 5.2e-06 25.3 0.2 3.0 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.1 KOO26882.1 - 1.5e-10 39.9 2.1 1.4e-05 24.2 0.0 3.0 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 KOO26882.1 - 2.1e-10 40.5 0.1 5.9e-10 39.1 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO26882.1 - 3.1e-09 35.9 0.4 0.0026 17.4 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 KOO26882.1 - 4.1e-08 32.7 0.3 1.2e-06 28.0 0.0 2.8 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_4 PF12763.2 KOO26882.1 - 0.039 13.7 0.0 0.12 12.1 0.0 1.8 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO26882.1 - 0.11 12.5 1.0 0.43 10.6 0.0 2.5 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region CAMSAP_CH PF11971.3 KOO26882.1 - 0.17 11.5 0.0 0.61 9.7 0.0 1.9 2 0 0 2 2 2 0 CAMSAP CH domain Pentapeptide_4 PF13599.1 KOO26883.1 - 0.00016 21.3 0.0 0.00022 20.9 0.0 1.1 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) p450 PF00067.17 KOO26884.1 - 0.071 11.6 0.1 0.11 11.0 0.0 1.1 1 0 0 1 1 1 0 Cytochrome P450 adh_short_C2 PF13561.1 KOO26885.1 - 1e-23 84.3 0.0 1.3e-23 84.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 KOO26885.1 - 0.028 14.3 0.0 0.049 13.5 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase KR PF08659.5 KOO26885.1 - 0.044 13.4 0.0 0.071 12.7 0.0 1.2 1 0 0 1 1 1 0 KR domain Sulfatase PF00884.18 KOO26886.1 - 3.6e-30 105.2 0.1 6e-30 104.4 0.1 1.3 1 0 0 1 1 1 1 Sulfatase Ricin_B_lectin PF00652.17 KOO26886.1 - 0.00033 20.6 0.5 0.11 12.5 0.0 2.9 3 0 0 3 3 3 2 Ricin-type beta-trefoil lectin domain DUF229 PF02995.12 KOO26886.1 - 0.058 11.8 0.0 0.082 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) EF-hand_1 PF00036.27 KOO26887.1 - 1.2e-36 121.2 0.9 3.3e-07 29.1 0.0 7.4 7 0 0 7 7 7 7 EF hand EF-hand_6 PF13405.1 KOO26887.1 - 1.4e-36 121.0 0.4 2.2e-06 27.0 0.0 7.4 7 0 0 7 7 7 7 EF-hand domain EF-hand_7 PF13499.1 KOO26887.1 - 1.1e-31 108.7 1.1 8.7e-10 38.6 0.0 4.7 4 1 0 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.1 KOO26887.1 - 5.9e-19 67.4 4.5 1.4e-06 27.8 0.1 6.2 4 2 2 6 6 6 5 EF-hand domain pair EF-hand_5 PF13202.1 KOO26887.1 - 2.4e-17 61.4 1.0 0.00033 19.8 0.0 7.1 7 0 0 7 7 7 3 EF hand SPARC_Ca_bdg PF10591.4 KOO26887.1 - 0.007 16.3 0.1 5.1 7.1 0.0 3.9 4 0 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region Toprim_2 PF13155.1 KOO26887.1 - 0.018 15.3 0.2 27 5.1 0.0 4.1 3 1 1 4 4 4 0 Toprim-like MSP1_C PF07462.6 KOO26887.1 - 7.8 4.7 5.0 15 3.7 3.4 1.4 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus FKBP_C PF00254.23 KOO26888.1 - 1.5e-20 72.9 0.0 2.6e-20 72.2 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Ank_2 PF12796.2 KOO26889.1 - 5.1e-49 164.5 31.6 1.1e-15 57.7 1.9 3.8 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Pkinase PF00069.20 KOO26889.1 - 3.4e-31 108.3 0.0 5.7e-31 107.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.1 KOO26889.1 - 7.4e-27 93.2 3.3 2.8e-08 34.0 0.1 5.0 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.12 KOO26889.1 - 4.5e-24 84.9 0.0 8.7e-24 83.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_5 PF13857.1 KOO26889.1 - 1.2e-23 82.5 12.7 1.3e-07 31.6 0.5 4.9 1 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.25 KOO26889.1 - 1.3e-20 72.1 21.3 6.6e-05 22.5 0.1 6.8 7 0 0 7 7 7 5 Ankyrin repeat Ank_3 PF13606.1 KOO26889.1 - 1.1e-13 49.9 6.5 0.054 13.7 0.0 6.1 6 0 0 6 6 6 4 Ankyrin repeat DUF4182 PF13790.1 KOO26889.1 - 7.8e-08 31.9 1.1 5.2 6.9 0.0 5.2 5 0 0 5 5 5 3 Domain of unknown function (DUF4182) Kinase-like PF14531.1 KOO26889.1 - 0.011 14.7 0.0 0.065 12.1 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Ank_2 PF12796.2 KOO26890.1 - 1.6e-24 86.0 0.0 1.6e-12 47.6 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO26890.1 - 3.1e-13 49.4 0.0 9.8e-07 28.8 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO26890.1 - 2.8e-12 45.7 0.4 0.00016 21.2 0.1 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOO26890.1 - 1.7e-08 34.7 0.0 3.2e-07 30.6 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO26890.1 - 2.6e-06 27.1 0.0 0.061 13.5 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat ShK PF01549.19 KOO26891.1 - 8.5e-13 48.4 25.1 1.3e-06 28.6 5.6 2.7 3 0 0 3 3 3 2 ShK domain-like 2OG-FeII_Oxy_3 PF13640.1 KOO26891.1 - 9.9e-12 45.2 0.4 2.1e-11 44.2 0.2 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO26891.1 - 1.6e-08 34.7 0.2 4e-08 33.4 0.1 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily zf-CCCH PF00642.19 KOO26891.1 - 0.0075 15.9 1.2 2.4 7.9 0.1 3.0 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Ank_2 PF12796.2 KOO26892.1 - 7.2e-108 353.1 69.0 5.4e-17 61.9 0.8 6.4 1 1 9 10 10 10 9 Ankyrin repeats (3 copies) Ank PF00023.25 KOO26892.1 - 7.5e-42 139.1 52.8 2.4e-05 23.9 0.2 12.5 13 0 0 13 13 13 10 Ankyrin repeat Ank_5 PF13857.1 KOO26892.1 - 1.1e-38 130.3 33.8 2.8e-06 27.4 0.5 9.6 1 1 9 10 10 10 10 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO26892.1 - 1e-36 124.6 12.9 4.8e-06 26.9 0.0 7.6 2 2 6 9 9 9 9 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO26892.1 - 4.7e-14 51.1 17.5 0.018 15.2 0.0 8.9 10 0 0 10 10 10 4 Ankyrin repeat Ion_trans_2 PF07885.11 KOO26892.1 - 0.00026 20.6 0.2 0.00043 19.9 0.2 1.4 1 0 0 1 1 1 1 Ion channel EF-hand_8 PF13833.1 KOO26892.1 - 0.0043 16.6 0.1 0.011 15.3 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO26892.1 - 0.0066 15.6 0.0 0.023 13.9 0.0 2.0 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO26892.1 - 0.017 15.2 0.0 0.041 14.0 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.1 KOO26892.1 - 0.018 14.8 0.0 0.048 13.5 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain Ion_trans PF00520.26 KOO26892.1 - 0.049 12.8 0.5 0.074 12.2 0.4 1.2 1 0 0 1 1 1 0 Ion transport protein IQ PF00612.22 KOO26892.1 - 0.051 13.2 0.1 0.16 11.6 0.1 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif EF-hand_5 PF13202.1 KOO26892.1 - 0.083 12.2 1.9 0.16 11.3 0.0 2.6 3 0 0 3 3 3 0 EF hand EF-hand_1 PF00036.27 KOO26893.1 - 2e-16 57.9 2.5 2.5e-07 29.4 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO26893.1 - 4.5e-14 51.8 1.4 1.5e-12 46.8 0.1 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.1 KOO26893.1 - 1.1e-13 51.0 1.6 1.1e-13 51.0 0.2 1.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO26893.1 - 1.9e-13 49.0 0.3 5e-07 29.0 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain Ion_trans PF00520.26 KOO26893.1 - 8e-13 48.0 4.7 2.8e-12 46.3 2.5 2.1 2 0 0 2 2 2 1 Ion transport protein EF-hand_5 PF13202.1 KOO26893.1 - 3.6e-09 35.5 5.3 2.4e-05 23.4 0.1 2.6 2 1 0 2 2 2 2 EF hand EF-hand_4 PF12763.2 KOO26893.1 - 2.1e-05 24.1 0.1 3.6e-05 23.4 0.1 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO26893.1 - 2.4e-05 24.1 0.0 0.00019 21.2 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO26893.1 - 0.072 13.1 0.1 0.11 12.5 0.1 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region DUF2453 PF10507.4 KOO26894.1 - 1.4e-38 131.1 2.6 1.7e-38 130.7 0.9 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2453) cNMP_binding PF00027.24 KOO26894.1 - 1.2e-07 31.3 0.0 2.1e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain AAA_22 PF13401.1 KOO26895.1 - 4.1e-07 30.1 0.0 1.3e-06 28.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 KOO26895.1 - 3.8e-05 23.4 0.0 5.9e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase NACHT PF05729.7 KOO26895.1 - 7.4e-05 22.4 0.1 0.00014 21.5 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 KOO26895.1 - 0.00011 22.1 0.2 0.00011 22.1 0.1 3.0 2 2 0 2 2 2 1 AAA ATPase domain CHAT PF12770.2 KOO26895.1 - 0.00093 18.3 0.6 0.00093 18.3 0.4 2.2 2 0 0 2 2 2 1 CHAT domain AAA_19 PF13245.1 KOO26895.1 - 0.0014 18.3 0.0 0.0065 16.1 0.0 2.2 1 0 0 1 1 1 1 Part of AAA domain AAA_25 PF13481.1 KOO26895.1 - 0.033 13.5 0.0 0.36 10.2 0.0 2.5 3 0 0 3 3 3 0 AAA domain AAA PF00004.24 KOO26895.1 - 0.087 13.0 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 KOO26895.1 - 0.094 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Zot PF05707.7 KOO26895.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) TPR_14 PF13428.1 KOO26895.1 - 0.14 12.8 5.6 0.14 12.8 1.4 3.2 2 0 0 2 2 1 0 Tetratricopeptide repeat DUF258 PF03193.11 KOO26895.1 - 0.19 10.8 0.0 0.38 9.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_23 PF13476.1 KOO26895.1 - 0.38 11.0 0.0 0.62 10.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.17 KOO26896.1 - 5.9e-06 25.3 0.0 1e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.1 KOO26896.1 - 1.4e-05 25.2 2.7 5e-05 23.3 1.8 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 KOO26896.1 - 1.7e-05 24.9 0.0 4.9e-05 23.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 KOO26896.1 - 0.00012 22.2 0.0 0.0002 21.5 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) CHAT PF12770.2 KOO26896.1 - 0.0002 20.5 1.1 0.00039 19.6 0.2 1.8 2 0 0 2 2 2 1 CHAT domain AAA_19 PF13245.1 KOO26896.1 - 0.0068 16.1 0.0 0.022 14.5 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain PhoH PF02562.11 KOO26896.1 - 0.011 14.9 0.0 0.019 14.1 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_17 PF13207.1 KOO26896.1 - 0.02 15.6 0.0 0.07 13.9 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.1 KOO26896.1 - 0.04 13.3 0.0 0.084 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.7 KOO26896.1 - 0.085 11.8 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus APH PF01636.18 KOO26897.1 - 4.6e-17 62.5 0.7 1.1e-16 61.2 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Exostosin PF03016.10 KOO26899.1 - 1e-26 93.7 0.0 1.5e-26 93.1 0.0 1.2 1 0 0 1 1 1 1 Exostosin family DUF4334 PF14232.1 KOO26899.1 - 0.068 12.8 0.1 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4334) Abhydrolase_3 PF07859.8 KOO26900.1 - 4.5e-14 52.5 0.0 8e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 KOO26900.1 - 1.7e-08 34.3 0.0 3e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO26900.1 - 0.00039 20.3 1.3 0.0013 18.6 0.8 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 KOO26900.1 - 0.036 13.2 0.0 0.076 12.2 0.0 1.4 1 1 0 1 1 1 0 Prolyl oligopeptidase family PH PF00169.24 KOO26901.1 - 7.5e-07 29.3 0.6 7.9e-06 26.0 0.4 2.1 1 1 0 1 1 1 1 PH domain PH_11 PF15413.1 KOO26901.1 - 0.00091 19.4 4.3 0.45 10.7 0.2 3.1 2 1 1 3 3 3 2 Pleckstrin homology domain PH_8 PF15409.1 KOO26901.1 - 0.0041 17.1 0.0 0.0086 16.1 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain V-SNARE_C PF12352.3 KOO26901.1 - 0.0068 16.4 2.0 0.014 15.4 1.4 1.5 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus DUF16 PF01519.11 KOO26901.1 - 0.016 15.3 1.5 0.026 14.7 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF16 GNAT_acetyltr_2 PF13718.1 KOO26901.1 - 0.098 11.9 1.0 0.14 11.4 0.7 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Mut7-C PF01927.11 KOO26902.1 - 5e-09 36.2 0.0 3.2e-08 33.6 0.0 1.9 1 1 0 1 1 1 1 Mut7-C RNAse domain Arm PF00514.18 KOO26903.1 - 4.1e-53 175.5 19.3 0.00011 21.9 0.1 10.4 10 0 0 10 10 10 10 Armadillo/beta-catenin-like repeat SIR2 PF02146.12 KOO26903.1 - 7.3e-32 110.5 0.0 1.7e-27 96.3 0.0 2.3 1 1 1 2 2 2 2 Sir2 family Arm_2 PF04826.8 KOO26903.1 - 1.8e-13 50.1 2.1 0.0094 15.0 0.0 5.1 1 1 3 5 5 5 5 Armadillo-like ART PF01129.13 KOO26903.1 - 0.029 13.4 0.0 0.044 12.8 0.0 1.2 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase Alkyl_sulf_dimr PF14863.1 KOO26903.1 - 0.4 10.8 11.5 4.9 7.3 0.0 4.9 2 2 3 6 6 6 0 Alkyl sulfatase dimerisation HEAT_EZ PF13513.1 KOO26903.1 - 0.5 10.9 31.6 1.3 9.5 0.1 6.4 1 1 8 9 9 9 0 HEAT-like repeat Clathrin PF00637.15 KOO26905.1 - 1.5e-08 34.3 14.8 0.0099 15.4 0.0 7.2 6 1 2 8 8 8 3 Region in Clathrin and VPS TPR_14 PF13428.1 KOO26905.1 - 8.1e-06 26.0 25.4 1.5 9.6 0.1 10.8 9 1 1 10 10 10 2 Tetratricopeptide repeat WD40 PF00400.27 KOO26905.1 - 0.00077 19.2 2.7 3.2 7.7 0.0 5.2 4 0 0 4 4 4 2 WD domain, G-beta repeat PPR_2 PF13041.1 KOO26905.1 - 0.0023 17.8 0.5 0.25 11.3 0.1 3.8 3 0 0 3 3 3 1 PPR repeat family Coatomer_WDAD PF04053.9 KOO26905.1 - 0.008 15.0 7.9 1.2 7.8 0.0 4.3 4 1 0 4 4 4 2 Coatomer WD associated region TPR_7 PF13176.1 KOO26905.1 - 0.014 15.1 21.8 21 5.2 0.0 8.5 8 1 0 8 8 8 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO26905.1 - 0.025 14.5 33.4 3.7 7.5 1.9 8.7 8 2 2 10 10 9 0 Tetratricopeptide repeat Apc3 PF12895.2 KOO26905.1 - 0.048 13.8 29.8 0.058 13.5 1.0 7.7 5 2 2 7 7 7 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.1 KOO26905.1 - 0.27 10.9 24.9 2.7 7.7 0.1 7.3 6 2 1 7 7 7 0 TPR repeat MIT PF04212.13 KOO26905.1 - 1.1 9.2 18.6 0.83 9.5 0.2 5.5 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_2 PF07719.12 KOO26905.1 - 7.3 6.7 35.5 0.41 10.6 0.8 9.2 10 0 0 10 10 10 0 Tetratricopeptide repeat IncA PF04156.9 KOO26907.1 - 0.00019 21.0 1.3 0.00026 20.6 0.9 1.3 1 0 0 1 1 1 1 IncA protein DASH_Spc34 PF08657.5 KOO26907.1 - 0.0035 17.0 1.7 0.0039 16.9 1.1 1.1 1 0 0 1 1 1 1 DASH complex subunit Spc34 DUF869 PF05911.6 KOO26907.1 - 0.016 13.4 3.6 0.019 13.2 2.5 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF869) Striatin PF08232.7 KOO26907.1 - 0.14 12.4 5.6 0.18 12.0 3.9 1.2 1 0 0 1 1 1 0 Striatin family MAD PF05557.8 KOO26907.1 - 0.31 9.1 8.0 0.37 8.8 5.5 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein TMF_DNA_bd PF12329.3 KOO26907.1 - 0.35 10.7 7.7 0.86 9.4 3.3 2.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Atg14 PF10186.4 KOO26907.1 - 0.58 9.0 5.7 0.69 8.8 4.0 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 ADIP PF11559.3 KOO26907.1 - 0.75 9.6 11.0 2.4 8.0 7.6 1.7 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding Spc24 PF08286.6 KOO26907.1 - 0.78 9.4 3.5 1.6 8.4 2.3 1.6 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Bap31 PF05529.7 KOO26907.1 - 1 8.7 5.0 4.4 6.7 3.4 2.0 1 1 0 1 1 1 0 B-cell receptor-associated protein 31-like DUF641 PF04859.7 KOO26907.1 - 2 8.1 5.9 3.6 7.3 0.9 1.8 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DivIC PF04977.10 KOO26907.1 - 3.1 7.3 11.9 11 5.5 5.9 2.7 1 1 2 3 3 3 0 Septum formation initiator DUF4407 PF14362.1 KOO26907.1 - 8.5 5.2 9.9 2.2 7.1 4.8 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF1517 PF07466.6 KOO26908.1 - 1.8e-21 76.3 0.0 3.5e-21 75.4 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1517) Aha1_N PF09229.6 KOO26909.1 - 4e-09 36.4 0.0 6.1e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal Ank_2 PF12796.2 KOO26910.1 - 8.8e-17 61.2 5.1 1.5e-11 44.4 0.3 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO26910.1 - 2e-16 58.8 2.9 1.1e-06 28.1 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.1 KOO26910.1 - 2.4e-10 39.6 0.7 0.0014 18.7 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 KOO26910.1 - 8.9e-08 32.1 2.7 0.00011 22.3 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO26910.1 - 3.6e-06 27.3 1.2 0.013 16.0 0.1 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Lipase_3 PF01764.20 KOO26911.1 - 8.5e-11 41.6 0.0 1.8e-10 40.5 0.0 1.5 1 1 0 1 1 1 1 Lipase (class 3) Abhydrolase_3 PF07859.8 KOO26911.1 - 0.0058 16.2 0.1 0.01 15.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold LRR_8 PF13855.1 KOO26912.1 - 1.3e-12 47.2 2.5 0.0011 18.6 0.0 4.5 3 1 1 5 5 5 3 Leucine rich repeat LRR_1 PF00560.28 KOO26912.1 - 6.6e-10 37.6 2.7 2.2 8.6 0.0 9.1 10 0 0 10 10 10 1 Leucine Rich Repeat LRR_4 PF12799.2 KOO26912.1 - 1.2e-08 34.3 0.1 0.04 13.5 0.0 5.4 4 2 1 5 5 5 3 Leucine Rich repeats (2 copies) EF-hand_1 PF00036.27 KOO26914.1 - 7.5e-13 46.7 0.2 1.4e-05 24.0 0.0 2.7 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO26914.1 - 4.7e-12 44.7 0.4 6.7e-05 22.4 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO26914.1 - 1.3e-11 43.3 0.6 0.00013 21.1 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO26914.1 - 2e-11 43.8 2.8 2.8e-07 30.5 0.1 2.3 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO26914.1 - 1.3e-06 27.9 0.1 0.071 12.7 0.0 2.7 3 0 0 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO26914.1 - 0.085 12.8 0.0 0.4 10.7 0.0 2.2 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region FAM196 PF15265.1 KOO26914.1 - 0.097 11.8 11.1 0.13 11.4 7.7 1.1 1 0 0 1 1 1 0 FAM196 family Asp-B-Hydro_N PF05279.6 KOO26914.1 - 4.5 7.0 26.3 9.6 5.9 18.3 1.6 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region PLRV_ORF5 PF01690.12 KOO26914.1 - 8.2 5.4 11.8 14 4.6 8.2 1.3 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein Pkinase PF00069.20 KOO26917.1 - 2.8e-46 157.7 0.0 1.1e-45 155.8 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.24 KOO26917.1 - 4.5e-29 100.0 0.1 1.2e-14 53.8 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.12 KOO26917.1 - 9.7e-25 87.1 0.0 1.6e-24 86.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.14 KOO26917.1 - 1.3e-07 31.7 0.0 3.4e-07 30.3 0.0 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain APH PF01636.18 KOO26917.1 - 0.00083 19.1 0.5 0.49 10.0 0.1 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family eIF3_subunit PF08597.5 KOO26918.1 - 1.9e-30 106.2 19.4 2.6e-30 105.7 13.5 1.1 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit MDH PF02315.11 KOO26918.1 - 0.077 12.9 2.4 0.099 12.5 0.7 1.9 2 0 0 2 2 2 0 Methanol dehydrogenase beta subunit DUF1104 PF06518.6 KOO26918.1 - 1 9.5 12.6 0.15 12.2 0.6 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1104) WD40 PF00400.27 KOO26919.1 - 1.3e-37 126.3 3.1 1e-09 37.9 0.1 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.3 KOO26919.1 - 0.031 12.4 0.9 2.2 6.2 0.1 2.6 2 1 0 2 2 2 0 Nucleoporin Nup120/160 ADK PF00406.17 KOO26920.1 - 2.8e-52 176.5 0.0 3.4e-52 176.3 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 KOO26920.1 - 1.9e-10 40.2 0.1 1.1e-08 34.5 0.0 2.5 1 1 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.1 KOO26920.1 - 3.9e-06 26.7 0.0 6.4e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOO26920.1 - 8.5e-06 24.9 0.0 1.3e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_17 PF13207.1 KOO26920.1 - 0.00024 21.8 0.0 0.00054 20.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOO26920.1 - 0.042 14.1 0.0 0.25 11.6 0.0 2.0 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 KOO26920.1 - 0.14 11.3 0.1 0.2 10.7 0.1 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA PF00004.24 KOO26920.1 - 0.15 12.2 0.1 0.27 11.4 0.1 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Glycos_transf_2 PF00535.21 KOO26922.1 - 0.08 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 Hira PF07569.6 KOO26923.1 - 7.6e-13 48.1 0.0 1e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 TUP1-like enhancer of split Arabinose_bd PF12625.2 KOO26923.1 - 0.04 13.7 3.7 0.06 13.1 1.7 1.8 1 1 1 2 2 2 0 Arabinose-binding domain of AraC transcription regulator, N-term NHL PF01436.16 KOO26925.1 - 4.1e-24 83.2 3.4 6.4e-08 32.1 0.0 6.1 6 1 0 6 6 6 4 NHL repeat SGL PF08450.7 KOO26925.1 - 0.0025 17.2 0.0 0.51 9.6 0.0 2.6 3 0 0 3 3 3 2 SMP-30/Gluconolaconase/LRE-like region PQQ_3 PF13570.1 KOO26925.1 - 0.016 15.5 0.1 24 5.3 0.0 3.5 3 0 0 3 3 3 0 PQQ-like domain DUF3638 PF12340.3 KOO26926.1 - 1.2e-18 66.9 0.0 1.1e-11 44.1 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3638) DUF3645 PF12359.3 KOO26926.1 - 3.7e-16 57.9 0.3 8e-16 56.8 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) PDZ_2 PF13180.1 KOO26926.1 - 0.0017 18.1 0.0 0.0043 16.9 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.19 KOO26926.1 - 0.0018 18.3 0.0 0.0045 17.1 0.0 1.7 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) EF-hand_8 PF13833.1 KOO26926.1 - 0.0051 16.3 0.0 0.036 13.7 0.0 2.4 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO26926.1 - 0.0063 15.7 0.0 0.045 13.0 0.0 2.4 2 0 0 2 2 2 1 EF hand DUF946 PF06101.6 KOO26926.1 - 0.008 14.2 0.0 0.014 13.4 0.0 1.3 1 0 0 1 1 1 1 Plant protein of unknown function (DUF946) EF-hand_5 PF13202.1 KOO26926.1 - 0.01 15.1 0.9 0.023 14.0 0.1 2.0 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO26926.1 - 0.031 14.4 0.0 0.17 12.0 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain pair DUF939_C PF11728.3 KOO26926.1 - 1.8 8.3 0.1 3.6 7.3 0.1 1.4 1 0 0 1 1 1 0 DUF939 C-terminal domain Membralin PF09746.4 KOO26926.1 - 8.1 5.3 0.5 13 4.6 0.3 1.2 1 0 0 1 1 1 0 Tumour-associated protein OPT PF03169.10 KOO26927.1 - 8.7e-122 407.6 34.3 1e-121 407.4 23.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein MFS_1 PF07690.11 KOO26928.1 - 1.9e-17 63.0 47.2 2e-13 49.7 13.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PAP2 PF01569.16 KOO26930.1 - 1.1e-19 70.3 5.1 1.1e-19 70.3 3.5 1.9 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.1 KOO26930.1 - 0.00012 21.6 1.4 0.00027 20.5 1.0 1.5 1 0 0 1 1 1 1 PAP2 superfamily ORC5_C PF14630.1 KOO26931.1 - 6.2e-39 134.0 0.0 2.1e-38 132.3 0.0 1.7 1 1 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_22 PF13401.1 KOO26931.1 - 1.5e-08 34.8 0.0 1e-07 32.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KOO26931.1 - 3.6e-08 33.6 3.5 4.1e-08 33.4 0.1 2.6 2 2 0 2 2 2 1 AAA ATPase domain Arch_ATPase PF01637.13 KOO26931.1 - 0.0013 18.4 0.0 0.002 17.8 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase AAA PF00004.24 KOO26931.1 - 0.022 14.9 0.0 0.037 14.2 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 KOO26931.1 - 0.059 13.0 0.0 0.14 11.7 0.0 1.6 1 1 0 1 1 1 0 NACHT domain RNA_helicase PF00910.17 KOO26931.1 - 0.098 12.8 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.9 KOO26931.1 - 0.18 11.5 0.0 0.33 10.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) EF-hand_1 PF00036.27 KOO26932.1 - 6.9e-14 50.0 4.1 0.00073 18.6 0.1 3.4 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.1 KOO26932.1 - 2e-09 37.4 3.9 3.7e-06 26.9 0.6 3.0 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO26932.1 - 2.2e-09 36.4 5.4 0.012 15.4 0.1 3.3 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.1 KOO26932.1 - 1.1e-08 33.9 3.5 0.01 15.1 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 KOO26932.1 - 6.5e-08 32.0 3.5 0.0065 16.0 0.1 3.4 3 0 0 3 3 3 3 EF-hand domain pair FHA PF00498.21 KOO26936.1 - 9.9e-16 57.6 0.1 1.8e-15 56.7 0.1 1.5 1 0 0 1 1 1 1 FHA domain zf-CXXC PF02008.15 KOO26936.1 - 3.5 7.5 11.8 11 5.9 6.5 2.5 2 0 0 2 2 2 0 CXXC zinc finger domain ADIP PF11559.3 KOO26937.1 - 0.3 10.9 27.5 0.029 14.2 6.1 3.7 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding GAS PF13851.1 KOO26937.1 - 0.49 9.5 20.8 0.096 11.8 0.4 3.6 1 1 3 4 4 4 0 Growth-arrest specific micro-tubule binding DUF1664 PF07889.7 KOO26937.1 - 2 8.2 4.4 4.6 7.0 0.3 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) YlqD PF11068.3 KOO26937.1 - 2.5 8.1 16.1 0.99 9.4 4.2 2.8 3 0 0 3 3 3 0 YlqD protein Rab5-bind PF09311.6 KOO26937.1 - 3.1 7.6 34.8 0.81 9.5 6.0 3.3 1 1 2 3 3 3 0 Rabaptin-like protein Spc7 PF08317.6 KOO26937.1 - 4.5 5.8 11.9 0.56 8.8 3.0 2.2 1 1 2 3 3 3 0 Spc7 kinetochore protein APG6 PF04111.7 KOO26937.1 - 5.1 6.0 25.7 4.7 6.1 7.2 2.4 1 1 1 2 2 2 0 Autophagy protein Apg6 CENP-F_leu_zip PF10473.4 KOO26937.1 - 7.8 6.3 27.5 0.11 12.4 3.7 3.4 1 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF972 PF06156.8 KOO26937.1 - 8.3 6.8 20.1 5.6 7.3 1.0 4.3 1 1 3 4 4 4 0 Protein of unknown function (DUF972) DUF4613 PF15390.1 KOO26937.1 - 9.2 4.2 7.8 12 3.8 4.7 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4613) AAA_13 PF13166.1 KOO26937.1 - 9.8 4.4 10.8 4.3 5.6 5.1 1.8 1 1 1 2 2 2 0 AAA domain Myb_DNA-binding PF00249.26 KOO26938.1 - 6.8e-12 45.2 0.1 1.6e-11 44.0 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain ubiquitin PF00240.18 KOO26938.1 - 5.5e-07 28.8 0.0 0.00045 19.5 0.0 2.5 2 0 0 2 2 2 2 Ubiquitin family Myb_DNA-bind_6 PF13921.1 KOO26938.1 - 0.0041 17.2 0.4 0.0086 16.1 0.0 1.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain zf-H2C2_2 PF13465.1 KOO26939.1 - 1.4e-20 72.4 23.8 3e-09 36.7 0.2 5.1 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.21 KOO26939.1 - 2.8e-19 68.2 19.9 0.00018 21.6 0.5 4.2 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOO26939.1 - 4e-15 54.9 14.5 0.0022 18.2 0.1 4.3 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KOO26939.1 - 1.2e-05 25.2 15.3 0.071 13.2 0.5 4.4 4 1 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 KOO26939.1 - 0.0081 16.3 4.6 0.27 11.4 0.2 3.6 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-TRAF PF02176.13 KOO26939.1 - 0.011 16.0 8.0 0.52 10.7 0.7 3.1 1 1 2 3 3 3 0 TRAF-type zinc finger CHORD PF04968.7 KOO26939.1 - 0.15 12.3 9.1 7.5 6.8 0.4 4.0 1 1 3 4 4 4 0 CHORD XPA_N PF01286.13 KOO26939.1 - 0.31 10.7 3.0 7.7 6.2 0.0 3.6 4 0 0 4 4 4 0 XPA protein N-terminal zf-CGNR PF11706.3 KOO26939.1 - 0.9 9.0 5.1 4.5 6.8 0.4 3.5 3 1 0 3 3 3 0 CGNR zinc finger CCAP PF11105.3 KOO26939.1 - 6.8 6.4 8.0 16 5.2 0.5 2.8 1 1 2 3 3 3 0 Arthropod cardioacceleratory peptide 2a TIG PF01833.19 KOO26940.1 - 2e-42 143.0 0.6 3.6e-07 30.0 0.0 6.8 6 2 0 6 6 6 6 IPT/TIG domain Glucodextran_B PF09136.5 KOO26940.1 - 0.053 13.6 3.2 0.054 13.6 0.1 2.5 2 0 0 2 2 2 0 Glucodextranase, domain B MT0933_antitox PF14013.1 KOO26941.1 - 5.3 7.2 6.0 0.52 10.4 1.0 1.6 2 0 0 2 2 2 0 MT0933-like antitoxin protein HC2 PF07382.6 KOO26942.1 - 0.00026 20.9 15.2 0.00045 20.1 10.5 1.3 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 Trypsin_2 PF13365.1 KOO26943.1 - 4.4e-13 49.2 0.7 7.8e-13 48.4 0.5 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.21 KOO26943.1 - 2.9e-08 33.5 0.2 6.3e-08 32.4 0.1 1.5 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.1 KOO26943.1 - 1.1e-05 25.2 0.0 4.4e-05 23.2 0.0 2.0 2 0 0 2 2 2 1 PDZ domain MIB_HERC2 PF06701.8 KOO26944.1 - 3.9e-16 58.7 9.7 9.8e-16 57.4 6.7 1.7 1 0 0 1 1 1 1 Mib_herc2 TIR PF01582.15 KOO26944.1 - 0.1 12.0 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 TIR domain FAD_binding_7 PF03441.9 KOO26945.1 - 1e-31 110.2 1.3 1.4e-31 109.7 0.9 1.1 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.13 KOO26945.1 - 8.2e-14 51.6 0.0 3.2e-13 49.7 0.0 1.9 2 0 0 2 2 2 1 DNA photolyase Med26 PF08711.6 KOO26945.1 - 0.0008 18.8 0.0 0.0016 17.9 0.0 1.5 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Ank_5 PF13857.1 KOO26946.1 - 1.9e-66 218.6 36.8 2.1e-09 37.3 0.1 11.4 3 3 9 12 12 12 12 Ankyrin repeats (many copies) Ank PF00023.25 KOO26946.1 - 1.4e-57 188.7 20.2 3.9e-05 23.2 0.0 13.3 13 0 0 13 13 13 12 Ankyrin repeat Ank_3 PF13606.1 KOO26946.1 - 1.2e-56 182.9 10.7 0.0016 18.5 0.0 13.3 13 0 0 13 13 13 12 Ankyrin repeat Ank_2 PF12796.2 KOO26946.1 - 4.3e-53 177.6 22.4 7.7e-10 38.9 0.2 7.5 2 1 4 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO26946.1 - 3.1e-44 148.5 7.3 6.4e-07 29.7 0.0 9.8 6 3 5 11 11 11 10 Ankyrin repeats (many copies) APC_15aa PF05972.6 KOO26946.1 - 0.001 18.8 0.0 0.1 12.5 0.0 2.6 2 0 0 2 2 2 1 APC 15 residue motif Beach PF02138.13 KOO26946.1 - 0.0024 17.3 0.0 9.7 5.5 0.0 5.0 3 2 1 5 5 5 1 Beige/BEACH domain MAPKK1_Int PF08923.5 KOO26946.1 - 0.0084 15.7 0.1 8.4 6.0 0.0 4.8 4 3 2 6 6 6 1 Mitogen-activated protein kinase kinase 1 interacting Ank_5 PF13857.1 KOO26947.1 - 3.3e-39 132.0 9.2 1.4e-08 34.6 0.2 7.7 4 2 4 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO26947.1 - 2e-28 95.6 3.1 0.0046 17.0 0.0 9.4 9 0 0 9 9 9 7 Ankyrin repeat Ank PF00023.25 KOO26947.1 - 2.6e-28 96.3 7.3 0.00022 20.8 0.0 9.3 8 1 0 8 8 8 7 Ankyrin repeat Ank_2 PF12796.2 KOO26947.1 - 4.8e-28 97.3 10.8 2.1e-07 31.1 0.1 5.1 3 1 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO26947.1 - 1.5e-22 79.5 0.6 0.00015 22.2 0.0 6.4 4 2 2 6 6 6 6 Ankyrin repeats (many copies) PARP PF00644.15 KOO26947.1 - 1.8e-08 34.1 0.0 1.3e-07 31.2 0.0 2.2 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DUF3395 PF11875.3 KOO26947.1 - 0.00058 19.5 0.0 0.0012 18.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) SH3_3 PF08239.6 KOO26947.1 - 0.024 14.8 0.0 0.066 13.4 0.0 1.8 1 0 0 1 1 1 0 Bacterial SH3 domain CTP_transf_2 PF01467.21 KOO26947.1 - 0.039 14.0 0.1 0.18 11.8 0.0 2.2 3 0 0 3 3 3 0 Cytidylyltransferase APC_15aa PF05972.6 KOO26947.1 - 0.12 12.4 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 APC 15 residue motif GTP_EFTU PF00009.22 KOO26948.1 - 3e-48 163.7 0.1 4.7e-48 163.1 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.19 KOO26948.1 - 1.2e-19 69.9 0.0 2.4e-19 68.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.18 KOO26948.1 - 1.7e-06 27.9 0.2 3.7e-06 26.8 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 KOO26948.1 - 3.9e-05 24.1 0.0 7.2e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein Septin PF00735.13 KOO26948.1 - 4e-05 22.7 0.1 6.2e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Septin EFG_II PF14492.1 KOO26948.1 - 0.0014 18.4 0.3 0.0029 17.4 0.2 1.4 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.20 KOO26948.1 - 0.0035 17.4 0.6 0.0089 16.1 0.1 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Dynamin_N PF00350.18 KOO26948.1 - 0.0047 16.7 0.0 0.19 11.5 0.0 2.5 2 1 1 3 3 3 1 Dynamin family AIG1 PF04548.11 KOO26948.1 - 0.012 14.7 0.0 0.019 14.1 0.0 1.3 1 0 0 1 1 1 0 AIG1 family FeoB_N PF02421.13 KOO26948.1 - 0.014 14.6 0.2 0.14 11.4 0.1 2.6 1 1 0 1 1 1 0 Ferrous iron transport protein B MFS_1 PF07690.11 KOO26950.1 - 1.3e-28 99.7 56.9 2.4e-21 75.8 14.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.11 KOO26951.1 - 1.7e-18 66.4 15.1 3e-18 65.6 10.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Acetyltransf_1 PF00583.19 KOO26951.1 - 0.0021 18.0 0.2 0.012 15.6 0.0 2.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Sugar_tr PF00083.19 KOO26951.1 - 0.0028 16.3 6.5 0.005 15.4 4.5 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter PUCC PF03209.10 KOO26951.1 - 0.075 11.7 11.8 0.19 10.4 8.2 1.6 1 0 0 1 1 1 0 PUCC protein AAA_16 PF13191.1 KOO26951.1 - 1.6 8.7 11.7 0.028 14.3 0.7 2.8 3 0 0 3 3 3 0 AAA ATPase domain RabGAP-TBC PF00566.13 KOO26953.1 - 6.4e-24 84.6 0.1 8.7e-24 84.1 0.1 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain YihI PF04220.7 KOO26954.1 - 0.02 14.2 0.3 0.48 9.7 0.1 2.1 2 0 0 2 2 2 0 Der GTPase activator (YihI) EF-hand_8 PF13833.1 KOO26956.1 - 2.5e-12 46.2 0.3 5e-12 45.2 0.2 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO26956.1 - 7.5e-09 34.2 0.2 1.8e-08 33.0 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO26956.1 - 8.7e-05 22.5 0.0 0.00015 21.8 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO26956.1 - 0.00011 21.7 0.6 0.0012 18.5 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.1 KOO26956.1 - 0.0026 17.0 0.9 0.0064 15.7 0.3 1.9 1 1 1 2 2 2 1 EF hand EF-hand_4 PF12763.2 KOO26956.1 - 0.033 13.9 0.0 0.069 12.8 0.0 1.5 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand DHquinase_II PF01220.14 KOO26957.1 - 8.6e-45 151.4 0.0 1.4e-44 150.7 0.0 1.3 1 1 0 1 1 1 1 Dehydroquinase class II Myc_N PF01056.13 KOO26958.1 - 0.49 9.4 8.8 0.035 13.2 2.1 1.9 2 0 0 2 2 2 0 Myc amino-terminal region DUF4611 PF15387.1 KOO26958.1 - 1 9.5 14.9 4.5 7.4 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) EBV-NA3 PF05009.7 KOO26958.1 - 1.1 8.5 2.8 1.8 7.7 2.0 1.3 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) CENP-B_dimeris PF09026.5 KOO26958.1 - 1.9 8.7 19.4 8.3 6.7 10.9 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Nucleoplasmin PF03066.10 KOO26958.1 - 2.7 7.5 15.5 0.37 10.3 7.2 1.9 2 0 0 2 2 2 0 Nucleoplasmin Nop14 PF04147.7 KOO26958.1 - 4.3 5.1 8.8 8.3 4.1 6.1 1.4 1 0 0 1 1 1 0 Nop14-like family Sigma70_ner PF04546.8 KOO26958.1 - 9.4 5.7 13.4 23 4.4 7.3 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region AAA PF00004.24 KOO26959.1 - 1.3e-40 138.6 0.0 2.2e-40 137.9 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOO26959.1 - 4.5e-08 33.2 0.2 5.4e-06 26.5 0.2 2.3 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 KOO26959.1 - 3.2e-06 27.1 0.0 6.3e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 KOO26959.1 - 2.8e-05 24.1 0.1 0.0014 18.6 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.9 KOO26959.1 - 7.4e-05 22.4 0.2 0.0003 20.5 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.8 KOO26959.1 - 8e-05 21.6 0.0 0.00015 20.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.7 KOO26959.1 - 0.00014 21.0 0.0 0.00027 20.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_25 PF13481.1 KOO26959.1 - 0.00089 18.7 0.5 0.049 13.0 0.1 2.3 1 1 1 2 2 2 1 AAA domain AAA_14 PF13173.1 KOO26959.1 - 0.003 17.4 0.0 0.0056 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 KOO26959.1 - 0.0046 16.3 0.0 0.0086 15.5 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein NB-ARC PF00931.17 KOO26959.1 - 0.0047 15.8 0.1 0.11 11.2 0.0 2.2 2 0 0 2 2 2 1 NB-ARC domain RNA_helicase PF00910.17 KOO26959.1 - 0.0066 16.6 0.0 0.017 15.2 0.0 1.8 1 0 0 1 1 1 1 RNA helicase AAA_19 PF13245.1 KOO26959.1 - 0.0096 15.6 0.2 0.019 14.6 0.2 1.4 1 0 0 1 1 1 1 Part of AAA domain AAA_28 PF13521.1 KOO26959.1 - 0.01 15.7 0.3 0.17 11.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 KOO26959.1 - 0.013 15.1 0.2 0.12 12.0 0.0 2.4 2 1 1 3 3 2 0 NACHT domain AAA_3 PF07726.6 KOO26959.1 - 0.014 14.9 0.1 0.047 13.2 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.7 KOO26959.1 - 0.017 14.1 0.0 0.032 13.3 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin KaiC PF06745.8 KOO26959.1 - 0.018 14.1 0.1 0.17 11.0 0.0 2.1 1 1 1 2 2 2 0 KaiC TIP49 PF06068.8 KOO26959.1 - 0.019 13.6 0.0 0.031 12.9 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus AAA_33 PF13671.1 KOO26959.1 - 0.02 14.7 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 KOO26959.1 - 0.022 15.6 0.1 0.061 14.1 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.1 KOO26959.1 - 0.026 14.0 0.0 0.059 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 KOO26959.1 - 0.027 13.9 0.0 0.12 11.8 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain NTPase_1 PF03266.10 KOO26959.1 - 0.039 13.6 0.7 0.41 10.3 0.2 2.6 2 1 0 2 2 2 0 NTPase AAA_18 PF13238.1 KOO26959.1 - 0.05 13.8 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 KOO26959.1 - 0.051 12.8 0.1 0.17 11.0 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein Sigma54_activ_2 PF14532.1 KOO26959.1 - 0.056 13.4 0.0 0.15 12.0 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain UPF0079 PF02367.12 KOO26959.1 - 0.063 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Mg_chelatase PF01078.16 KOO26959.1 - 0.071 12.2 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF2075 PF09848.4 KOO26959.1 - 0.083 11.8 0.0 0.12 11.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Inositol_P PF00459.20 KOO26960.1 - 6.4e-19 68.3 0.1 1.3e-18 67.3 0.0 1.5 1 1 0 1 1 1 1 Inositol monophosphatase family SHS2_FTSA PF02491.15 KOO26960.1 - 0.11 12.3 0.1 19 5.2 0.0 2.3 2 0 0 2 2 2 0 SHS2 domain inserted in FTSA DIRP PF06584.8 KOO26961.1 - 4.9e-19 68.2 0.5 9.2e-19 67.3 0.0 1.7 2 0 0 2 2 2 1 DIRP Rab5-bind PF09311.6 KOO26961.1 - 0.085 12.7 1.3 0.38 10.6 0.1 2.5 3 0 0 3 3 3 0 Rabaptin-like protein UPF0047 PF01894.12 KOO26964.1 - 2.6e-29 101.4 0.0 4e-29 100.8 0.0 1.3 1 1 0 1 1 1 1 Uncharacterised protein family UPF0047 DUF4457 PF14652.1 KOO26965.1 - 1.1e-48 165.9 0.0 8e-26 90.7 0.0 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF4457) cNMP_binding PF00027.24 KOO26965.1 - 9.1e-21 73.4 0.0 2.1e-20 72.3 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain CRAL_TRIO PF00650.15 KOO26965.1 - 1.3e-12 47.5 0.0 2.3e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain Sulfatase PF00884.18 KOO26965.1 - 2.5e-05 23.6 0.0 3.9e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.17 KOO26965.1 - 0.00018 20.9 0.1 0.0003 20.2 0.1 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase CTDII PF01556.13 KOO26966.1 - 1.8e-27 95.0 0.1 2e-21 75.6 0.0 2.2 2 0 0 2 2 2 2 DnaJ C terminal domain DnaJ PF00226.26 KOO26966.1 - 1.2e-23 82.5 0.3 1.9e-23 81.9 0.2 1.3 1 0 0 1 1 1 1 DnaJ domain MRP-L27 PF09809.4 KOO26966.1 - 0.023 14.2 0.1 0.046 13.3 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L27 DUF4457 PF14652.1 KOO26967.1 - 2.8e-26 92.2 0.0 4.8e-26 91.5 0.0 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4457) EPTP PF03736.12 KOO26969.1 - 1.8e-20 72.3 0.0 0.00052 19.7 0.1 6.0 6 0 0 6 6 6 5 EPTP domain Kinesin PF00225.18 KOO26969.1 - 4e-16 58.6 0.0 9e-16 57.4 0.0 1.5 2 0 0 2 2 2 1 Kinesin motor domain zf-MYND PF01753.13 KOO26969.1 - 2.7e-10 39.9 19.5 2.7e-10 39.9 13.5 1.9 2 0 0 2 2 2 1 MYND finger TPR_10 PF13374.1 KOO26969.1 - 0.00094 19.0 0.2 0.004 17.0 0.1 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat DUF342 PF03961.8 KOO26969.1 - 2.6 6.3 8.1 2 6.7 4.4 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF342) Methyltransf_21 PF05050.7 KOO26970.1 - 1.9e-12 47.4 0.0 2.6e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain RRF PF01765.14 KOO26970.1 - 0.027 13.9 0.0 0.047 13.1 0.0 1.3 1 0 0 1 1 1 0 Ribosome recycling factor U-box PF04564.10 KOO26971.1 - 1e-13 51.0 0.0 2e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO26971.1 - 4.5e-07 29.2 0.0 8e-07 28.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit UPF0542 PF15086.1 KOO26971.1 - 0.026 14.2 0.1 0.1 12.3 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 zf-RING_UBOX PF13445.1 KOO26971.1 - 0.029 14.0 0.0 0.06 13.0 0.0 1.5 1 0 0 1 1 1 0 RING-type zinc-finger DUF962 PF06127.6 KOO26971.1 - 0.032 14.1 0.1 0.049 13.5 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF962) Cyt_c_ox_IV PF12270.3 KOO26971.1 - 0.035 13.8 0.1 0.065 12.9 0.1 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV Tetraspannin PF00335.15 KOO26971.1 - 0.052 12.8 0.7 0.072 12.3 0.5 1.2 1 0 0 1 1 1 0 Tetraspanin family DUF588 PF04535.7 KOO26971.1 - 0.16 11.5 3.1 4.1 6.9 0.0 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF588) PALP PF00291.20 KOO26973.1 - 1.8e-59 201.4 0.4 2.1e-59 201.2 0.3 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme EF-hand_1 PF00036.27 KOO26974.1 - 2e-11 42.2 0.6 3.6e-05 22.7 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO26974.1 - 3.1e-08 33.6 0.4 4.9e-08 32.9 0.3 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO26974.1 - 8.5e-07 28.3 0.0 0.002 17.8 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO26974.1 - 1.5e-05 24.1 0.1 0.0017 17.6 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.1 KOO26974.1 - 0.00049 19.6 1.2 0.13 11.9 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.1 KOO26974.1 - 0.00055 19.7 0.2 0.0012 18.7 0.0 1.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.2 KOO26974.1 - 0.0066 16.1 0.1 0.011 15.5 0.1 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand UPF0444 PF15475.1 KOO26974.1 - 3.4 7.7 18.2 8.5 6.5 0.3 3.0 3 1 1 4 4 4 0 Transmembrane protein C12orf23, UPF0444 PC-Esterase PF13839.1 KOO26975.1 - 3.2e-08 33.7 2.4 8.9e-08 32.2 1.7 1.7 1 1 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p CS PF04969.11 KOO26976.1 - 1.8e-05 25.2 0.0 3.4e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 CS domain MEDS PF14417.1 KOO26976.1 - 0.032 13.3 1.9 0.052 12.5 1.3 1.3 1 0 0 1 1 1 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain U79_P34 PF03064.11 KOO26976.1 - 0.033 13.7 0.3 0.053 13.0 0.2 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Atrophin-1 PF03154.10 KOO26976.1 - 3.1 5.8 10.8 5 5.1 7.5 1.2 1 0 0 1 1 1 0 Atrophin-1 family adh_short PF00106.20 KOO26977.1 - 9e-07 28.9 0.2 9e-07 28.9 0.1 4.1 5 1 1 6 6 6 1 short chain dehydrogenase adh_short_C2 PF13561.1 KOO26977.1 - 0.00051 19.8 0.0 0.013 15.2 0.0 2.8 3 0 0 3 3 3 1 Enoyl-(Acyl carrier protein) reductase FdhD-NarQ PF02634.10 KOO26977.1 - 0.091 12.2 5.3 0.095 12.1 0.0 2.4 2 0 0 2 2 2 0 FdhD/NarQ family GLE1 PF07817.8 KOO26977.1 - 0.18 10.6 2.9 0.34 9.8 2.0 1.3 1 0 0 1 1 1 0 GLE1-like protein GST_C PF00043.20 KOO26978.1 - 7.8e-11 41.8 0.0 1.3e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 KOO26978.1 - 1.9e-07 31.1 0.0 5.4e-07 29.7 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 KOO26978.1 - 1.4e-06 28.3 0.0 3.7e-06 27.0 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 KOO26978.1 - 9.4e-06 25.5 0.0 1.8e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KOO26978.1 - 1.4e-05 24.9 0.1 3.7e-05 23.5 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 KOO26978.1 - 4.2e-05 23.9 0.0 7.6e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Pkinase PF00069.20 KOO26980.1 - 3.2e-30 105.1 0.0 3.8e-30 104.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO26980.1 - 5.9e-12 45.2 0.0 6.5e-12 45.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO26980.1 - 0.022 14.5 0.5 0.046 13.4 0.1 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Choline_kinase PF01633.15 KOO26980.1 - 0.14 11.6 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF2919 PF11143.3 KOO26981.1 - 0.029 14.2 0.7 0.029 14.2 0.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2919) EF-hand_5 PF13202.1 KOO26981.1 - 0.095 12.0 0.0 0.18 11.1 0.0 1.5 1 0 0 1 1 1 0 EF hand DUF3311 PF11755.3 KOO26981.1 - 2.4 7.7 6.7 1.2 8.7 0.5 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3311) GRIP PF01465.15 KOO26983.1 - 1.4e-08 34.1 2.2 0.014 14.8 0.0 3.3 2 1 1 3 3 3 3 GRIP domain HAP1_N PF04849.8 KOO26983.1 - 0.14 11.0 6.5 0.051 12.5 0.7 2.1 2 0 0 2 2 2 0 HAP1 N-terminal conserved region DUF501 PF04417.7 KOO26983.1 - 0.32 10.8 3.9 0.13 12.1 0.5 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF501) SurA_N PF09312.6 KOO26983.1 - 1.1 9.1 5.8 9.9 6.0 0.3 3.0 2 1 1 3 3 3 0 SurA N-terminal domain Polysacc_deac_1 PF01522.16 KOO26984.1 - 1.6e-20 73.0 0.0 5.2e-20 71.3 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide deacetylase Polysacc_deac_2 PF04748.8 KOO26984.1 - 0.0043 16.1 0.0 0.009 15.0 0.0 1.6 1 0 0 1 1 1 1 Divergent polysaccharide deacetylase Pho88 PF10032.4 KOO26985.1 - 9.8e-30 103.2 0.0 1.5e-29 102.6 0.0 1.2 1 0 0 1 1 1 1 Phosphate transport (Pho88) Caps_synth PF05704.7 KOO26986.1 - 5e-10 39.0 1.1 5e-10 39.0 0.7 1.7 1 1 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.10 KOO26986.1 - 0.0014 18.9 0.0 0.006 16.9 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif Ion_trans PF00520.26 KOO26988.1 - 1.2e-14 54.0 12.1 3.2e-14 52.6 8.4 1.7 1 1 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO26988.1 - 1.1e-10 41.0 8.5 1.1e-10 41.0 5.9 2.2 2 1 0 2 2 2 1 Ion channel cNMP_binding PF00027.24 KOO26988.1 - 1.4e-10 40.7 0.0 3.1e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_N PF08412.5 KOO26988.1 - 0.0055 15.9 1.3 0.012 14.8 0.0 2.3 3 0 0 3 3 3 1 Ion transport protein N-terminal TIR_2 PF13676.1 KOO26990.1 - 0.00034 20.7 0.0 0.0038 17.3 0.0 2.8 3 0 0 3 3 3 1 TIR domain Atg14 PF10186.4 KOO26991.1 - 0.035 13.0 0.2 0.035 13.0 0.1 3.3 4 0 0 4 4 4 0 UV radiation resistance protein and autophagy-related subunit 14 Transposase_22 PF02994.9 KOO26991.1 - 0.089 11.2 2.8 1.6 7.1 1.7 2.1 2 0 0 2 2 2 0 L1 transposable element DUF1907 PF08925.6 KOO26991.1 - 0.17 10.9 0.9 0.32 10.0 0.6 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1907) Fib_alpha PF08702.5 KOO26991.1 - 0.39 10.8 4.3 16 5.5 1.3 2.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Prominin PF05478.6 KOO26991.1 - 0.96 6.8 3.0 5 4.5 0.0 2.1 2 0 0 2 2 2 0 Prominin AAA_13 PF13166.1 KOO26991.1 - 6.3 5.1 7.4 5 5.4 1.3 2.2 2 0 0 2 2 2 0 AAA domain DUF724 PF05266.9 KOO26991.1 - 6.7 6.2 11.4 0.54 9.8 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Peptidase_S49 PF01343.13 KOO26992.1 - 3.3e-41 140.6 0.0 6.1e-41 139.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S49 Peptidase_S49_N PF08496.5 KOO26992.1 - 3.4e-16 59.4 0.0 1.6e-13 50.7 0.0 2.8 2 0 0 2 2 2 2 Peptidase family S49 N-terminal SDH_sah PF01972.11 KOO26992.1 - 0.0078 15.0 0.1 0.0078 15.0 0.1 1.7 2 0 0 2 2 2 1 Serine dehydrogenase proteinase LSM PF01423.17 KOO26993.1 - 2e-18 65.6 0.5 2.7e-18 65.2 0.3 1.2 1 0 0 1 1 1 1 LSM domain Leu_zip PF15294.1 KOO26993.1 - 0.0095 15.0 0.2 0.011 14.9 0.2 1.1 1 0 0 1 1 1 1 Leucine zipper ADK PF00406.17 KOO26994.1 - 7.8e-58 194.6 0.0 1.1e-57 194.1 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 KOO26994.1 - 8.2e-13 47.7 0.0 1.6e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.1 KOO26994.1 - 2.4e-05 25.1 0.0 4e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 KOO26994.1 - 0.004 17.0 0.0 0.006 16.4 0.0 1.4 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOO26994.1 - 0.036 13.1 0.0 0.048 12.7 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.1 KOO26994.1 - 0.063 13.5 0.0 0.24 11.6 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.1 KOO26994.1 - 0.11 12.0 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Mg_chelatase PF01078.16 KOO26994.1 - 0.11 11.6 0.1 0.16 11.1 0.1 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.12 KOO26994.1 - 0.12 11.8 0.0 0.25 10.7 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein RuvB_N PF05496.7 KOO26994.1 - 0.12 11.3 0.0 0.21 10.6 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus TPR_11 PF13414.1 KOO26995.1 - 7.6e-22 76.7 6.6 1.6e-15 56.5 1.3 2.3 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 KOO26995.1 - 2.9e-18 64.6 4.3 1.9e-07 30.3 0.1 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO26995.1 - 9.8e-11 40.7 7.4 0.00036 20.2 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO26995.1 - 1.1e-07 32.3 10.9 5.9e-05 23.6 2.3 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO26995.1 - 1.7e-06 27.7 0.1 0.11 12.7 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO26995.1 - 7e-05 22.6 1.0 7e-05 22.6 0.7 2.5 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO26995.1 - 0.00037 20.0 0.8 0.12 12.1 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF3856 PF12968.2 KOO26995.1 - 0.006 16.4 0.4 0.011 15.5 0.3 1.5 1 0 0 1 1 1 1 Domain of Unknown Function (DUF3856) MIT PF04212.13 KOO26995.1 - 0.012 15.4 2.1 0.69 9.8 0.0 2.4 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain Apc3 PF12895.2 KOO26995.1 - 0.05 13.7 1.2 0.094 12.8 0.8 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 KOO26995.1 - 0.051 13.3 3.0 5.4 7.0 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO26995.1 - 0.082 12.7 0.7 0.082 12.7 0.5 2.6 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 KOO26995.1 - 0.096 13.0 1.2 0.2 12.0 0.3 2.0 1 1 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO26995.1 - 7.9 7.4 9.9 3 8.7 0.1 3.6 2 1 2 4 4 4 0 Tetratricopeptide repeat Glyco_tranf_2_4 PF13704.1 KOO26996.1 - 4.1e-08 33.4 0.3 9.3e-08 32.2 0.2 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 p450 PF00067.17 KOO26997.1 - 7e-33 113.8 0.0 8.1e-33 113.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TPR_2 PF07719.12 KOO26998.1 - 9.7e-32 106.3 12.1 2.5e-06 26.9 0.0 8.0 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_11 PF13414.1 KOO26998.1 - 3e-31 106.8 7.6 5.2e-12 45.2 0.0 5.5 3 2 3 6 6 6 5 TPR repeat TPR_1 PF00515.23 KOO26998.1 - 6.3e-26 88.8 6.2 9.9e-07 28.1 0.0 7.0 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.1 KOO26998.1 - 4.4e-20 71.8 8.0 5.7e-09 36.4 1.6 6.1 3 2 5 8 8 8 6 Tetratricopeptide repeat TPR_8 PF13181.1 KOO26998.1 - 1.5e-18 65.0 0.1 0.00028 20.4 0.0 6.5 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_12 PF13424.1 KOO26998.1 - 2.5e-18 65.7 12.1 3.6e-05 23.6 0.3 5.7 2 1 5 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.1 KOO26998.1 - 1.1e-14 53.3 0.4 0.044 14.0 0.0 6.7 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.1 KOO26998.1 - 1.3e-14 53.3 22.8 4.4e-05 23.7 0.5 7.8 3 3 5 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOO26998.1 - 5e-14 52.3 15.5 5.9e-05 23.3 0.6 5.4 4 1 2 6 6 5 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOO26998.1 - 5.6e-12 45.2 6.9 0.00028 21.1 0.0 6.2 7 0 0 7 7 5 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO26998.1 - 2.4e-09 36.3 10.2 0.033 13.9 0.0 6.6 8 0 0 8 8 6 2 Tetratricopeptide repeat Apc3 PF12895.2 KOO26998.1 - 1.2e-08 34.9 5.4 4e-05 23.6 0.5 3.8 3 1 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 KOO26998.1 - 3e-06 27.0 16.6 0.0088 15.8 0.0 5.8 3 3 4 7 7 7 2 Tetratricopeptide repeat TPR_15 PF13429.1 KOO26998.1 - 4.7e-06 25.8 6.3 0.54 9.2 0.1 4.7 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_4 PF07721.9 KOO26998.1 - 3.2e-05 23.9 16.4 0.31 11.5 0.0 6.7 6 2 1 7 7 5 2 Tetratricopeptide repeat NARP1 PF12569.3 KOO26998.1 - 0.00014 20.7 3.6 0.23 10.1 0.1 3.4 3 1 1 4 4 4 2 NMDA receptor-regulated protein 1 TPR_10 PF13374.1 KOO26998.1 - 0.0023 17.7 14.2 0.43 10.5 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_21 PF09976.4 KOO26998.1 - 0.019 14.9 12.5 0.059 13.2 0.8 3.3 4 1 0 4 4 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO26998.1 - 0.027 14.3 0.2 5.4 6.9 0.0 3.4 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat SHNi-TPR PF10516.4 KOO26998.1 - 0.07 12.3 7.1 16 4.7 0.1 5.0 5 0 0 5 5 5 0 SHNi-TPR Coatomer_E PF04733.9 KOO26998.1 - 0.75 8.9 4.8 7.8 5.5 0.1 2.9 2 1 1 3 3 3 0 Coatomer epsilon subunit MIT PF04212.13 KOO26998.1 - 4.8 7.1 10.5 3.6 7.5 0.0 4.5 6 0 0 6 6 5 0 MIT (microtubule interacting and transport) domain DUF445 PF04286.7 KOO26999.1 - 4e-10 39.7 2.2 4.8e-05 23.0 0.0 3.3 2 1 1 3 3 3 3 Protein of unknown function (DUF445) HSP33 PF01430.14 KOO27000.1 - 3.3e-48 164.2 0.0 3.8e-48 164.0 0.0 1.0 1 0 0 1 1 1 1 Hsp33 protein Sel1 PF08238.7 KOO27001.1 - 3.4e-13 49.7 10.5 6e-06 26.7 1.9 4.1 4 0 0 4 4 4 3 Sel1 repeat U-box PF04564.10 KOO27001.1 - 4.2e-10 39.4 0.0 8.9e-10 38.3 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO27001.1 - 0.00012 21.5 0.0 0.00032 20.1 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.10 KOO27002.1 - 0.072 13.0 0.2 0.096 12.6 0.1 1.3 1 0 0 1 1 1 0 U-box domain Sel1 PF08238.7 KOO27003.1 - 7.9e-16 58.1 17.8 5.5e-08 33.1 1.7 4.0 4 0 0 4 4 4 3 Sel1 repeat U-box PF04564.10 KOO27003.1 - 2.3e-12 46.7 0.0 3.8e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO27003.1 - 0.0032 16.9 0.0 0.0056 16.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit TPR_6 PF13174.1 KOO27003.1 - 0.041 14.3 1.9 0.45 11.0 0.2 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat Sel1 PF08238.7 KOO27004.1 - 2.3e-12 47.0 10.7 0.00011 22.6 0.4 3.9 4 0 0 4 4 4 3 Sel1 repeat U-box PF04564.10 KOO27004.1 - 2.4e-10 40.2 0.0 4.3e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO27004.1 - 0.00024 20.5 0.0 0.00043 19.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit TPR_11 PF13414.1 KOO27005.1 - 7.9e-13 47.8 8.3 4.7e-09 35.7 1.6 2.5 2 0 0 2 2 2 2 TPR repeat DnaJ PF00226.26 KOO27005.1 - 3.5e-11 42.6 0.5 1.3e-10 40.8 0.0 2.2 2 0 0 2 2 2 1 DnaJ domain TPR_19 PF14559.1 KOO27005.1 - 0.00071 19.8 8.5 0.031 14.6 2.2 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO27005.1 - 0.059 14.0 9.5 0.2 12.4 2.3 3.3 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO27005.1 - 0.065 13.9 6.0 0.29 11.8 0.3 3.7 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO27005.1 - 0.071 13.0 5.0 0.82 9.7 0.3 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.7 KOO27007.1 - 4e-15 55.8 10.6 2.8e-05 24.6 0.2 4.7 4 1 1 5 5 5 3 Sel1 repeat U-box PF04564.10 KOO27007.1 - 1.9e-10 40.5 0.0 4.6e-10 39.3 0.0 1.6 2 0 0 2 2 2 1 U-box domain zf-Nse PF11789.3 KOO27007.1 - 0.00024 20.5 0.0 0.00086 18.7 0.0 1.9 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit TPR_11 PF13414.1 KOO27008.1 - 9.9e-35 118.0 26.5 2.7e-13 49.3 0.0 5.3 2 1 1 5 5 5 5 TPR repeat TPR_2 PF07719.12 KOO27008.1 - 7.1e-29 97.3 20.6 7.8e-05 22.2 0.0 7.9 8 0 0 8 8 7 6 Tetratricopeptide repeat TPR_1 PF00515.23 KOO27008.1 - 5.3e-27 92.2 16.5 5.7e-05 22.5 0.0 8.5 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_17 PF13431.1 KOO27008.1 - 3.3e-22 76.7 19.8 0.00021 21.2 0.1 7.2 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.1 KOO27008.1 - 1.2e-20 73.6 31.8 4e-08 33.7 0.1 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.1 KOO27008.1 - 2.7e-14 52.3 23.1 0.0027 18.2 0.4 7.4 4 1 3 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.1 KOO27008.1 - 1.6e-13 50.3 21.1 6.3e-06 26.0 0.3 5.6 1 1 6 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.1 KOO27008.1 - 1.4e-11 43.3 0.5 0.049 13.4 0.0 7.4 7 1 1 8 8 8 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOO27008.1 - 8.3e-11 41.5 11.9 1.1e-05 25.1 0.0 5.1 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOO27008.1 - 2.8e-09 36.8 6.9 0.044 14.2 0.0 6.1 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO27008.1 - 5e-09 36.3 9.0 8e-06 26.1 0.4 4.8 4 1 2 6 6 5 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO27008.1 - 1.4e-08 33.8 6.0 0.12 12.2 0.0 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat Apc3 PF12895.2 KOO27008.1 - 0.00023 21.2 0.7 0.045 13.8 0.1 4.2 1 1 5 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.1 KOO27008.1 - 0.0052 16.8 12.8 1.8 8.7 0.0 5.3 3 2 3 6 6 6 2 Tetratricopeptide repeat TOM20_plant PF06552.7 KOO27008.1 - 0.069 12.7 2.4 7.9 6.0 0.4 3.1 1 1 1 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_15 PF13429.1 KOO27008.1 - 0.11 11.5 11.9 0.32 10.0 2.5 3.9 2 1 1 3 3 3 0 Tetratricopeptide repeat Glyoxalase PF00903.20 KOO27008.1 - 0.12 12.3 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MIT PF04212.13 KOO27008.1 - 0.3 11.0 3.3 25 4.8 0.0 3.8 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain BTAD PF03704.12 KOO27008.1 - 1.2 9.4 9.2 0.61 10.3 0.2 3.5 1 1 2 5 5 5 0 Bacterial transcriptional activator domain TPR_10 PF13374.1 KOO27008.1 - 2.3 8.2 24.1 3.3 7.7 0.5 6.2 7 0 0 7 7 5 0 Tetratricopeptide repeat Bestrophin PF01062.16 KOO27009.1 - 3.8e-26 91.7 1.9 4.8e-26 91.3 1.3 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel MotB_plug PF13677.1 KOO27009.1 - 1.4 8.2 0.0 1.4 8.2 0.0 2.8 2 1 0 2 2 2 0 Membrane MotB of proton-channel complex MotA/MotB Oxidored_q2 PF00420.19 KOO27009.1 - 5.1 6.7 10.8 0.31 10.6 3.3 2.1 3 0 0 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Sel1 PF08238.7 KOO27010.1 - 6e-12 45.7 12.8 4.4e-05 23.9 0.7 4.2 4 0 0 4 4 4 3 Sel1 repeat U-box PF04564.10 KOO27010.1 - 9.8e-11 41.4 0.0 2.2e-10 40.3 0.0 1.5 2 0 0 2 2 2 1 U-box domain zf-Nse PF11789.3 KOO27010.1 - 0.00011 21.5 0.0 0.0002 20.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit DUF469 PF04320.9 KOO27010.1 - 0.078 13.7 0.1 4.7 8.0 0.0 2.6 2 1 0 2 2 2 0 Protein with unknown function (DUF469) LRR_4 PF12799.2 KOO27011.1 - 9.3e-16 57.0 34.0 1.3e-05 24.6 0.0 10.7 9 2 1 10 10 10 5 Leucine Rich repeats (2 copies) EF-hand_1 PF00036.27 KOO27011.1 - 2.8e-07 29.3 2.4 9.3e-07 27.7 1.7 2.0 1 0 0 1 1 1 1 EF hand LRR_6 PF13516.1 KOO27011.1 - 1.2e-06 27.9 28.9 3.3 8.0 0.1 13.9 16 0 0 16 16 16 1 Leucine Rich repeat EF-hand_5 PF13202.1 KOO27011.1 - 2.1e-06 26.8 2.2 8.5e-06 24.8 1.5 2.1 1 0 0 1 1 1 1 EF hand LRR_1 PF00560.28 KOO27011.1 - 2.1e-06 26.9 22.5 12 6.3 0.0 11.6 11 0 0 11 11 11 1 Leucine Rich Repeat LRR_8 PF13855.1 KOO27011.1 - 4.6e-05 23.0 33.4 0.0014 18.3 1.5 9.0 7 2 2 10 10 10 4 Leucine rich repeat EF-hand_6 PF13405.1 KOO27011.1 - 0.00027 20.5 0.5 0.0013 18.4 0.4 2.2 1 0 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.1 KOO27011.1 - 0.00049 19.6 2.3 0.0023 17.4 1.6 2.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.1 KOO27011.1 - 0.0037 17.3 0.7 0.012 15.7 0.5 1.9 1 0 0 1 1 1 1 EF-hand domain pair AAA_19 PF13245.1 KOO27011.1 - 0.0071 16.0 0.1 0.03 14.0 0.0 2.1 1 0 0 1 1 1 1 Part of AAA domain UvrD-helicase PF00580.16 KOO27011.1 - 0.026 13.8 4.2 0.14 11.3 0.0 2.8 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain Peptidase_S28 PF05577.7 KOO27013.1 - 1.1e-65 221.9 0.2 8.6e-49 166.2 0.0 2.1 2 0 0 2 2 2 2 Serine carboxypeptidase S28 Abhydrolase_6 PF12697.2 KOO27013.1 - 3.8e-08 33.4 2.8 4.7e-08 33.1 0.7 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S37 PF05576.6 KOO27013.1 - 2e-05 23.2 0.0 3.4e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 PS-10 peptidase S37 Abhydrolase_1 PF00561.15 KOO27013.1 - 0.0001 21.9 0.1 0.00022 20.8 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 KOO27013.1 - 0.032 13.4 0.2 0.059 12.5 0.1 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Galactosyl_T PF01762.16 KOO27014.1 - 3.2e-06 26.9 0.0 5.2e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.11 KOO27014.1 - 0.062 12.5 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Fringe-like TAXi_N PF14543.1 KOO27015.1 - 3.7e-22 79.0 2.8 7.3e-22 78.0 2.0 1.5 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Asp PF00026.18 KOO27015.1 - 3e-17 62.8 0.0 2.2e-13 50.1 0.0 2.3 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_C PF14541.1 KOO27015.1 - 9.4e-08 31.7 0.0 1.9e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal TAFH PF07531.9 KOO27017.1 - 0.15 11.7 0.0 0.36 10.4 0.0 1.6 1 0 0 1 1 1 0 NHR1 homology to TAF SnAC PF14619.1 KOO27018.1 - 0.18 12.0 4.7 0.26 11.4 3.2 1.2 1 0 0 1 1 1 0 Snf2-ATP coupling, chromatin remodelling complex Glyco_trans_1_2 PF13524.1 KOO27018.1 - 0.75 10.1 3.8 2 8.7 2.6 1.7 1 1 0 1 1 1 0 Glycosyl transferases group 1 His_Phos_1 PF00300.17 KOO27019.1 - 1.5e-36 125.9 0.0 2e-36 125.4 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) PH PF00169.24 KOO27020.1 - 3.8e-08 33.4 0.0 5.8e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 PH domain PH_8 PF15409.1 KOO27020.1 - 0.00064 19.7 0.5 0.0016 18.4 0.4 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.1 KOO27020.1 - 0.0032 17.6 0.1 0.0047 17.1 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain ArfGap PF01412.13 KOO27020.1 - 0.071 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf WW PF00397.21 KOO27020.1 - 0.076 12.8 3.1 0.36 10.7 0.1 2.8 2 0 0 2 2 2 0 WW domain PAS PF00989.19 KOO27022.1 - 2.4e-48 162.6 0.1 2.2e-16 59.6 0.0 3.8 3 0 0 3 3 3 3 PAS fold PAS_9 PF13426.1 KOO27022.1 - 1.5e-37 128.0 0.1 7.2e-15 55.2 0.1 3.7 3 0 0 3 3 3 3 PAS domain PAS_4 PF08448.5 KOO27022.1 - 4.4e-31 107.1 0.2 1.8e-09 37.5 0.0 4.1 3 0 0 3 3 3 3 PAS fold HATPase_c PF02518.21 KOO27022.1 - 1.8e-25 88.7 0.4 6.3e-25 87.0 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 KOO27022.1 - 2e-23 82.5 0.1 7.2e-23 80.7 0.0 2.1 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.20 KOO27022.1 - 9.1e-17 60.8 0.5 5.3e-16 58.3 0.0 2.8 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.6 KOO27022.1 - 3.9e-13 49.2 0.0 1.4e-06 28.3 0.0 3.6 3 0 0 3 3 3 3 PAS fold Hpt PF01627.18 KOO27022.1 - 1.8e-12 47.1 8.5 2.8e-10 40.0 0.7 3.6 3 0 0 3 3 3 2 Hpt domain PAS_8 PF13188.1 KOO27022.1 - 1.7e-11 43.5 0.0 0.0051 16.6 0.0 4.3 4 0 0 4 4 3 3 PAS domain PAS_10 PF13596.1 KOO27022.1 - 2.3e-09 37.4 0.0 2.7e-05 24.3 0.0 2.9 2 0 0 2 2 2 2 PAS domain PAS_7 PF12860.2 KOO27022.1 - 0.024 14.6 0.1 10 6.1 0.0 4.2 3 1 0 3 3 3 0 PAS fold HATPase_c_3 PF13589.1 KOO27022.1 - 0.049 13.2 0.0 0.16 11.6 0.0 1.8 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K_oxygenase PF13434.1 KOO27024.1 - 3.3e-06 26.2 0.0 2.9e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_7 PF13241.1 KOO27024.1 - 0.0035 17.5 0.0 0.0078 16.4 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Pyr_redox_3 PF13738.1 KOO27024.1 - 0.0059 16.6 0.0 0.009 16.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Oxidored_nitro PF00148.14 KOO27024.1 - 0.021 13.4 1.1 0.026 13.1 0.0 1.8 2 0 0 2 2 2 0 Nitrogenase component 1 type Oxidoreductase Pyr_redox PF00070.22 KOO27024.1 - 0.045 14.1 0.0 0.12 12.8 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF1311 PF07007.7 KOO27024.1 - 1.7 8.7 6.2 5.2 7.2 1.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1311) DUF2201_N PF13203.1 KOO27024.1 - 8.5 5.4 12.5 1.6 7.8 6.2 1.6 1 1 1 2 2 2 0 Putative metallopeptidase domain EF-hand_6 PF13405.1 KOO27025.1 - 9.3e-27 90.4 14.1 5.2e-06 25.9 0.0 6.9 6 0 0 6 6 6 6 EF-hand domain EF-hand_1 PF00036.27 KOO27025.1 - 1.3e-26 89.8 18.9 1.9e-05 23.6 0.2 6.8 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.1 KOO27025.1 - 6.4e-25 87.0 13.1 3.8e-09 36.5 0.4 5.0 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO27025.1 - 4.6e-17 60.5 17.7 0.0002 20.5 0.5 6.6 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.1 KOO27025.1 - 2.2e-13 49.5 19.3 0.00014 21.4 0.7 6.2 4 2 2 6 6 6 5 EF-hand domain pair LRR_6 PF13516.1 KOO27026.1 - 8.6e-05 22.2 0.3 1.5 9.0 0.0 4.8 5 0 0 5 5 5 1 Leucine Rich repeat Pep_M12B_propep PF01562.14 KOO27026.1 - 0.074 12.8 0.2 5.2 6.8 0.1 2.5 2 1 0 2 2 2 0 Reprolysin family propeptide Ribosomal_S16 PF00886.14 KOO27027.1 - 7.4e-21 73.6 0.1 1e-20 73.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S16 zf-RING_2 PF13639.1 KOO27028.1 - 4.4e-05 23.2 6.1 9.2e-05 22.1 4.2 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 KOO27028.1 - 0.056 13.1 6.3 0.14 11.8 4.4 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.3 KOO27028.1 - 0.098 12.6 2.8 0.26 11.3 1.9 1.8 1 0 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_2 PF13923.1 KOO27028.1 - 0.11 12.5 6.6 0.32 11.0 4.6 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 KOO27028.1 - 0.63 10.1 6.7 2.4 8.3 3.9 2.3 1 1 1 2 2 2 0 RING-H2 zinc finger TPR_12 PF13424.1 KOO27029.1 - 1.9e-34 117.3 18.4 6.3e-16 58.0 0.9 6.1 3 2 2 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.1 KOO27029.1 - 6.9e-34 114.7 27.2 7.4e-08 32.0 0.0 9.8 7 3 1 8 8 8 7 Tetratricopeptide repeat EF-hand_1 PF00036.27 KOO27029.1 - 7.8e-11 40.4 0.0 0.00041 19.4 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO27029.1 - 1.4e-10 41.1 0.1 3.6e-10 39.8 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO27029.1 - 6.4e-09 35.2 0.3 1.5e-07 30.8 0.0 2.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO27029.1 - 7.1e-09 34.6 0.2 0.00037 19.6 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO27029.1 - 2.1e-08 33.3 0.1 0.00033 20.3 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain TPR_1 PF00515.23 KOO27029.1 - 7.2e-08 31.7 14.7 0.22 11.1 0.1 6.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO27029.1 - 2.1e-07 30.2 16.3 0.17 11.7 0.0 6.9 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_11 PF13414.1 KOO27029.1 - 3.4e-06 26.6 17.0 0.0088 15.6 0.4 5.5 3 1 1 5 5 5 3 TPR repeat TPR_17 PF13431.1 KOO27029.1 - 7.3e-06 25.7 6.0 0.38 11.0 0.1 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO27029.1 - 0.00012 21.7 26.1 0.23 11.4 0.0 7.7 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO27029.1 - 0.0051 17.4 8.9 0.0075 16.9 2.0 7.1 7 0 0 7 7 6 2 Tetratricopeptide repeat MutS_III PF05192.13 KOO27029.1 - 0.05 13.3 2.8 0.22 11.2 1.9 2.3 1 1 0 1 1 1 0 MutS domain III EF-hand_4 PF12763.2 KOO27029.1 - 0.15 11.8 0.0 0.39 10.4 0.0 1.6 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand TPR_8 PF13181.1 KOO27029.1 - 3.3 7.7 14.7 14 5.7 0.0 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat Adap_comp_sub PF00928.16 KOO27030.1 - 1.2e-62 211.3 0.0 1.5e-62 211.0 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family VKG_Carbox PF05090.9 KOO27031.1 - 2.1e-17 63.1 3.7 1.5e-15 56.9 2.2 2.7 1 1 1 2 2 2 2 Vitamin K-dependent gamma-carboxylase C2 PF00168.25 KOO27033.1 - 1.2e-14 53.8 0.1 2e-14 53.2 0.1 1.4 1 0 0 1 1 1 1 C2 domain cNMP_binding PF00027.24 KOO27033.1 - 6.2e-13 48.3 0.0 1.1e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ank_3 PF13606.1 KOO27033.1 - 0.02 15.0 4.4 4 7.9 0.1 4.4 4 0 0 4 4 4 0 Ankyrin repeat Ank_5 PF13857.1 KOO27033.1 - 0.049 13.9 0.3 24 5.3 0.0 3.8 3 1 1 4 4 4 0 Ankyrin repeats (many copies) Bestrophin PF01062.16 KOO27034.1 - 7e-24 84.2 0.5 1.4e-20 73.4 0.0 2.1 1 1 1 2 2 2 2 Bestrophin, RFP-TM, chloride channel Peptidase_C2 PF00648.16 KOO27035.1 - 3e-37 128.2 0.0 6.5e-37 127.1 0.0 1.5 1 1 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.17 KOO27035.1 - 3.3e-13 49.5 0.0 6.4e-07 29.1 0.0 2.7 2 1 0 2 2 2 2 Calpain large subunit, domain III PALP PF00291.20 KOO27035.1 - 0.042 13.0 0.0 0.078 12.1 0.0 1.3 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme DUF2475 PF10629.4 KOO27036.1 - 1e-08 35.3 14.7 0.034 14.4 0.6 4.6 4 0 0 4 4 4 4 Protein of unknown function (DUF2475) Pax2_C PF12403.3 KOO27036.1 - 2 8.0 5.8 2.1 8.0 0.1 2.9 2 1 1 3 3 3 0 Paired-box protein 2 C terminal zf-CSL PF05207.8 KOO27037.1 - 4e-13 48.6 1.0 6.8e-13 47.9 0.7 1.4 1 0 0 1 1 1 1 CSL zinc finger zinc_ribbon_4 PF13717.1 KOO27037.1 - 0.016 14.9 0.4 0.025 14.2 0.2 1.3 1 0 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 KOO27037.1 - 0.022 14.3 0.4 0.036 13.6 0.3 1.3 1 0 0 1 1 1 0 zinc-ribbon domain RRS1 PF04939.7 KOO27037.1 - 0.13 11.7 0.3 0.16 11.4 0.2 1.1 1 0 0 1 1 1 0 Ribosome biogenesis regulatory protein (RRS1) Metallophos PF00149.23 KOO27038.1 - 0.0014 18.0 0.0 0.002 17.5 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KOO27038.1 - 0.0016 18.2 0.0 0.003 17.4 0.0 1.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Peptidase_C6 PF00851.13 KOO27038.1 - 0.11 11.1 0.0 0.15 10.7 0.0 1.1 1 0 0 1 1 1 0 Helper component proteinase EF-hand_5 PF13202.1 KOO27039.1 - 2.5e-18 64.4 8.2 8.6e-06 24.8 0.2 3.9 3 1 1 4 4 4 3 EF hand EF-hand_1 PF00036.27 KOO27039.1 - 6.3e-17 59.5 0.9 6.5e-05 21.9 0.0 3.4 2 1 1 3 3 3 3 EF hand EF-hand_7 PF13499.1 KOO27039.1 - 7e-15 54.9 0.6 3.1e-07 30.4 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO27039.1 - 1.7e-14 52.3 2.1 2.1e-05 24.0 0.1 3.3 2 1 1 3 3 3 3 EF-hand domain EF-hand_8 PF13833.1 KOO27039.1 - 2.6e-08 33.3 1.5 0.037 13.6 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain pair 5_nucleotid_C PF02872.13 KOO27039.1 - 0.00072 19.5 0.0 0.0013 18.7 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Sterol_MT_C PF08498.5 KOO27041.1 - 3e-19 68.7 0.2 5.1e-19 67.9 0.1 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.7 KOO27041.1 - 5.4e-19 68.4 0.0 1.2e-18 67.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO27041.1 - 7.8e-15 54.7 0.0 1.1e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 KOO27041.1 - 2.5e-12 46.4 0.0 3.7e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.1 KOO27041.1 - 3.8e-11 43.2 0.1 7.2e-11 42.3 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO27041.1 - 2.2e-09 37.2 0.0 3.4e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO27041.1 - 3e-07 29.7 0.0 4.7e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 KOO27041.1 - 1.6e-06 28.6 0.0 3.2e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO27041.1 - 3.6e-06 27.3 0.0 1e-05 25.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO27041.1 - 2.8e-05 24.1 0.1 7e-05 22.8 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain Tubulin PF00091.20 KOO27042.1 - 1.2e-25 90.6 0.0 1.3e-25 90.4 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Arm PF00514.18 KOO27043.1 - 1.5e-12 46.8 34.0 0.0028 17.4 0.7 9.2 9 0 0 9 9 9 6 Armadillo/beta-catenin-like repeat Neurochondrin PF05536.6 KOO27043.1 - 0.066 11.5 9.6 0.034 12.4 1.4 2.9 3 0 0 3 3 3 0 Neurochondrin DUF913 PF06025.7 KOO27043.1 - 0.21 10.2 0.0 0.37 9.4 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CCDC66 PF15236.1 KOO27044.1 - 1.7 8.2 26.3 0.03 13.9 13.5 1.5 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 66 Skp1 PF01466.14 KOO27045.1 - 0.00015 21.7 0.0 0.00041 20.3 0.0 1.7 1 0 0 1 1 1 1 Skp1 family, dimerisation domain LRR_6 PF13516.1 KOO27045.1 - 0.00035 20.3 1.0 3.5 7.9 0.0 3.8 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.28 KOO27045.1 - 0.00038 20.0 0.0 1.9 8.8 0.0 3.0 2 0 0 2 2 2 2 Leucine Rich Repeat LRR_7 PF13504.1 KOO27045.1 - 0.0019 18.0 1.4 2.1 8.9 0.1 3.3 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.2 KOO27045.1 - 0.03 13.9 1.3 0.3 10.7 0.9 2.3 1 1 0 1 1 1 0 Leucine Rich repeats (2 copies) DUF1269 PF06897.7 KOO27046.1 - 0.098 12.7 1.1 0.19 11.7 0.2 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1269) Pyr_redox PF00070.22 KOO27046.1 - 0.36 11.2 3.2 3.5 8.1 0.1 2.9 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DUF1612 PF07756.7 KOO27046.1 - 1.5 8.9 6.4 1.1 9.3 2.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1612) TMF_DNA_bd PF12329.3 KOO27046.1 - 5.8 6.7 14.8 0.8 9.5 2.7 3.5 2 2 2 4 4 4 0 TATA element modulatory factor 1 DNA binding EF-hand_1 PF00036.27 KOO27047.1 - 0.012 14.8 0.2 0.14 11.4 0.0 2.5 2 0 0 2 2 2 0 EF hand TPR_19 PF14559.1 KOO27047.1 - 0.014 15.7 11.4 0.25 11.6 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat EF-hand_6 PF13405.1 KOO27047.1 - 0.04 13.8 0.2 0.14 12.1 0.2 1.9 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.1 KOO27047.1 - 0.048 13.8 0.0 0.15 12.1 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.1 KOO27047.1 - 0.12 11.7 0.4 0.31 10.4 0.3 1.8 1 0 0 1 1 1 0 EF hand P2X_receptor PF00864.14 KOO27047.1 - 0.27 9.8 0.1 0.43 9.2 0.0 1.2 1 0 0 1 1 1 0 ATP P2X receptor Sec23_trunk PF04811.10 KOO27049.1 - 5.1e-61 206.1 0.0 7.9e-61 205.5 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 KOO27049.1 - 7.8e-31 105.5 0.4 3.4e-30 103.5 0.3 2.1 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 KOO27049.1 - 4.3e-30 104.0 0.1 8.1e-30 103.2 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 KOO27049.1 - 1.1e-15 56.8 6.6 6.4e-15 54.4 5.1 1.9 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 KOO27049.1 - 3.7e-12 45.7 0.0 6.5e-12 44.9 0.0 1.4 1 0 0 1 1 1 1 Gelsolin repeat Sec23_helical PF04815.10 KOO27050.1 - 5.4e-31 106.0 0.4 1.2e-30 104.9 0.3 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 KOO27050.1 - 1.5e-30 105.5 0.1 2.9e-30 104.6 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.17 KOO27050.1 - 1.4e-12 47.1 0.0 2.5e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 Gelsolin repeat Sec23_trunk PF04811.10 KOO27050.1 - 0.013 14.8 0.1 0.025 13.9 0.0 1.5 1 0 0 1 1 1 0 Sec23/Sec24 trunk domain EF-hand_1 PF00036.27 KOO27052.1 - 1.1e-35 118.1 2.6 8.9e-05 21.5 0.1 6.3 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.1 KOO27052.1 - 7.7e-34 112.5 2.2 0.00011 21.7 0.1 6.4 6 0 0 6 6 6 6 EF-hand domain EF-hand_7 PF13499.1 KOO27052.1 - 4.3e-30 103.6 0.5 6.9e-09 35.7 0.0 4.3 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO27052.1 - 5.6e-30 101.3 3.5 0.00042 19.5 0.0 6.4 6 0 0 6 6 6 6 EF hand EF-hand_8 PF13833.1 KOO27052.1 - 2.1e-21 75.3 2.0 0.00028 20.4 0.1 6.2 4 2 2 6 6 6 6 EF-hand domain pair Nipped-B_C PF12830.2 KOO27052.1 - 0.25 10.9 0.0 1.1 8.8 0.0 1.8 2 0 0 2 2 2 0 Sister chromatid cohesion C-terminus TK PF00265.13 KOO27053.1 - 6e-33 113.8 0.0 7.3e-33 113.5 0.0 1.0 1 0 0 1 1 1 1 Thymidine kinase AAA_30 PF13604.1 KOO27053.1 - 2.6e-05 23.8 0.0 4.9e-05 22.9 0.0 1.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 KOO27053.1 - 9.8e-05 22.5 0.0 0.00015 21.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 KOO27053.1 - 0.0018 18.1 0.1 0.0042 16.9 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_10 PF12846.2 KOO27053.1 - 0.039 13.3 0.1 3.7 6.9 0.0 2.1 1 1 1 2 2 2 0 AAA-like domain DUF2075 PF09848.4 KOO27053.1 - 0.05 12.5 0.0 0.059 12.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DJ-1_PfpI PF01965.19 KOO27054.1 - 1.3e-26 92.7 0.0 1.6e-26 92.5 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family DUF4066 PF13278.1 KOO27054.1 - 2.2e-05 23.7 0.0 2.5e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Putative amidotransferase GATase_3 PF07685.9 KOO27054.1 - 0.02 14.5 0.0 0.025 14.1 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.23 KOO27054.1 - 0.078 12.4 0.0 0.23 10.8 0.0 1.7 1 1 0 1 1 1 0 Glutamine amidotransferase class-I Ank PF00023.25 KOO27055.1 - 7.5e-10 38.1 0.7 0.00011 21.8 0.2 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.2 KOO27055.1 - 1.3e-08 35.0 0.0 3e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO27055.1 - 9.1e-06 25.7 0.0 0.0068 16.6 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO27055.1 - 0.00056 19.9 0.1 0.04 14.1 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.1 KOO27055.1 - 0.0011 19.4 0.0 0.0049 17.3 0.0 2.1 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Sfi1 PF08457.5 KOO27056.1 - 1.7e-05 23.4 70.3 0.0057 15.1 4.2 6.3 3 2 2 6 6 6 4 Sfi1 spindle body protein EF-hand_1 PF00036.27 KOO27056.1 - 0.085 12.2 0.1 0.33 10.3 0.0 2.0 2 0 0 2 2 2 0 EF hand OmpH PF03938.9 KOO27056.1 - 0.67 9.8 17.7 2.8 7.8 0.8 4.2 4 0 0 4 4 4 0 Outer membrane protein (OmpH-like) Kinesin PF00225.18 KOO27057.1 - 2.8e-100 335.2 0.2 2.4e-99 332.1 0.0 2.3 2 0 0 2 2 2 1 Kinesin motor domain Pox_A_type_inc PF04508.7 KOO27057.1 - 0.042 13.6 0.1 0.042 13.6 0.1 4.0 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat Arm PF00514.18 KOO27060.1 - 0.0008 19.1 1.2 0.24 11.2 0.2 3.0 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat HECT PF00632.20 KOO27061.1 - 9.3e-80 268.1 0.0 8.1e-79 265.0 0.0 2.1 3 0 0 3 3 3 1 HECT-domain (ubiquitin-transferase) RCC1 PF00415.13 KOO27061.1 - 3.5e-21 75.1 4.5 3.2e-09 36.8 0.4 3.5 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO27061.1 - 4.2e-07 29.3 18.0 0.0035 16.9 2.2 3.7 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat CAP_N PF01213.14 KOO27061.1 - 1.5 8.0 4.3 3.2 6.9 3.0 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal FAM176 PF14851.1 KOO27062.1 - 0.11 12.2 2.9 0.12 12.0 2.0 1.2 1 0 0 1 1 1 0 FAM176 family Abhydrolase_5 PF12695.2 KOO27063.1 - 1.2e-08 34.7 0.0 2.1e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 KOO27063.1 - 1.4e-06 27.7 0.0 3.1e-06 26.5 0.0 1.5 2 0 0 2 2 2 1 Prolyl oligopeptidase family NeA_P2 PF12312.3 KOO27063.1 - 0.0017 17.6 0.4 0.0069 15.6 0.0 1.9 2 0 0 2 2 2 1 Nepovirus subgroup A polyprotein CAP_N PF01213.14 KOO27063.1 - 2.4 7.3 11.1 0.12 11.6 0.9 2.1 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal KAP PF05804.7 KOO27064.1 - 5.1e-159 530.4 0.9 6e-159 530.2 0.6 1.0 1 0 0 1 1 1 1 Kinesin-associated protein (KAP) FoP_duplication PF13865.1 KOO27064.1 - 0.0033 17.8 4.1 0.0082 16.5 2.9 1.6 1 0 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 Beta-lactamase PF00144.19 KOO27064.1 - 0.0039 16.2 2.7 2.6 6.9 0.0 2.9 3 0 0 3 3 3 2 Beta-lactamase PUL PF08324.6 KOO27064.1 - 0.0087 14.8 0.1 0.023 13.4 0.0 1.8 2 0 0 2 2 2 1 PUL domain Arm PF00514.18 KOO27064.1 - 0.13 12.1 8.6 2.3 8.1 0.0 4.5 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 KOO27064.1 - 5.5 7.6 10.4 0.52 10.8 0.3 4.4 4 2 0 4 4 4 0 HEAT-like repeat Methyltransf_18 PF12847.2 KOO27066.1 - 5.6e-08 33.3 0.2 1.1e-07 32.4 0.2 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO27066.1 - 5.3e-07 29.6 8.9 3.4e-06 27.0 6.2 2.5 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 KOO27066.1 - 1.2e-05 24.5 1.8 1.7e-05 24.1 1.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 KOO27066.1 - 0.00011 21.5 0.4 0.00019 20.8 0.3 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PRMT5 PF05185.11 KOO27066.1 - 0.00031 19.7 0.0 0.0015 17.5 0.0 1.9 2 0 0 2 2 2 1 PRMT5 arginine-N-methyltransferase Methyltransf_24 PF13578.1 KOO27066.1 - 0.00073 20.3 0.3 0.0016 19.2 0.2 1.7 1 1 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 KOO27066.1 - 0.0026 17.3 0.0 0.0038 16.8 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_31 PF13847.1 KOO27066.1 - 0.0034 16.9 0.0 0.0052 16.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.10 KOO27066.1 - 0.024 14.0 0.1 0.037 13.3 0.1 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_4 PF02390.12 KOO27066.1 - 0.035 13.1 0.0 0.058 12.4 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase CMAS PF02353.15 KOO27066.1 - 0.037 13.1 0.0 0.053 12.5 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase CbiX PF01903.12 KOO27068.1 - 7.9e-09 35.5 0.1 0.0055 16.7 0.0 3.2 2 2 0 2 2 2 2 CbiX DUF1537 PF07005.6 KOO27069.1 - 0.68 9.5 14.0 0.1 12.2 6.7 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF1537 EF-hand_1 PF00036.27 KOO27070.1 - 6.1e-05 22.0 0.1 0.00021 20.3 0.0 1.9 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 KOO27070.1 - 0.00023 20.7 0.8 0.00054 19.5 0.6 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO27070.1 - 0.00039 20.0 0.5 0.0013 18.4 0.1 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.1 KOO27070.1 - 0.0013 18.0 0.7 0.0027 16.9 0.1 1.9 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO27070.1 - 0.0037 17.3 0.3 0.016 15.3 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain pair DUF1896 PF08989.5 KOO27070.1 - 0.0061 16.4 0.4 0.0061 16.4 0.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1896) MAP7 PF05672.6 KOO27070.1 - 0.0081 15.5 6.6 0.0081 15.5 4.6 2.4 2 0 0 2 2 2 1 MAP7 (E-MAP-115) family DUF4407 PF14362.1 KOO27070.1 - 0.07 12.0 6.7 0.088 11.7 4.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SpoIIIAH PF12685.2 KOO27070.1 - 1.7 8.1 7.4 2.8 7.4 5.1 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein NPV_P10 PF05531.7 KOO27071.1 - 0.7 10.1 9.5 0.63 10.3 2.0 3.7 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Glyco_hydro_65N PF03636.10 KOO27072.1 - 0.3 10.3 2.0 0.46 9.7 1.4 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain BCDHK_Adom3 PF10436.4 KOO27073.1 - 1.8e-44 151.1 0.1 2.4e-44 150.7 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 KOO27073.1 - 3.7e-17 62.0 0.0 1.5e-16 60.0 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 KOO27073.1 - 0.00013 21.6 0.0 0.00021 20.9 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase UBA PF00627.26 KOO27075.1 - 2.3e-05 24.0 1.1 9.2e-05 22.1 0.2 2.5 2 0 0 2 2 2 1 UBA/TS-N domain UBA_4 PF14555.1 KOO27075.1 - 0.0008 18.8 0.1 0.0066 15.9 0.0 2.5 2 0 0 2 2 2 1 UBA-like domain RA PF00788.18 KOO27075.1 - 0.11 13.0 0.0 16 6.0 0.0 2.7 2 0 0 2 2 2 0 Ras association (RalGDS/AF-6) domain UVR PF02151.14 KOO27075.1 - 8.8 5.9 12.2 3.9 7.1 0.4 3.8 3 0 0 3 3 3 0 UvrB/uvrC motif adh_short_C2 PF13561.1 KOO27076.1 - 1.2e-92 310.0 0.0 1.4e-92 309.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF647 PF04884.9 KOO27077.1 - 1.6e-51 174.9 4.9 1.9e-51 174.6 3.4 1.0 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis Ank_2 PF12796.2 KOO27079.1 - 2.8e-36 123.7 4.4 1.2e-15 57.5 0.1 3.0 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO27079.1 - 1.9e-21 74.6 5.9 6.2e-08 32.0 0.1 3.9 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 KOO27079.1 - 2.5e-21 75.6 1.7 2.9e-13 49.9 0.2 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO27079.1 - 3.9e-20 69.9 2.3 8.6e-06 25.5 0.0 4.9 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.1 KOO27079.1 - 1.9e-18 66.0 11.1 4.3e-07 29.9 0.4 5.3 3 1 2 5 5 5 3 Ankyrin repeats (many copies) TPR_11 PF13414.1 KOO27080.1 - 0.045 13.3 4.7 0.061 12.9 0.2 2.5 2 1 0 2 2 2 0 TPR repeat PABP PF00658.13 KOO27081.1 - 3.2e-16 58.7 0.4 5.3e-16 58.0 0.3 1.3 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain Kelch_4 PF13418.1 KOO27081.1 - 6.3e-14 51.4 7.0 2.6e-08 33.4 0.0 4.2 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_3 PF13415.1 KOO27081.1 - 9e-10 38.4 10.5 3.4e-05 23.8 0.1 4.9 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO27081.1 - 6.6e-08 32.3 0.0 0.15 12.0 0.0 3.8 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.1 KOO27081.1 - 1.2e-07 31.5 1.8 0.019 15.1 0.0 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.20 KOO27081.1 - 0.15 11.6 4.4 11 5.6 0.0 3.9 4 0 0 4 4 4 0 Kelch motif Filaggrin PF03516.8 KOO27082.1 - 0.025 15.0 0.2 0.025 15.0 0.2 1.9 2 0 0 2 2 2 0 Filaggrin Helicase_C PF00271.26 KOO27083.1 - 2.1e-16 59.5 0.8 3.3e-16 58.9 0.5 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Phage_integrase PF00589.17 KOO27083.1 - 0.083 12.5 1.1 0.16 11.6 0.5 1.6 2 1 0 2 2 2 0 Phage integrase family Ras PF00071.17 KOO27084.1 - 5.6e-63 211.1 0.5 6.5e-63 210.9 0.4 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO27084.1 - 1.1e-19 71.1 0.0 1.8e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO27084.1 - 8.6e-17 60.9 0.3 1.1e-16 60.6 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 KOO27084.1 - 6.4e-07 28.9 0.5 1.3e-06 27.9 0.2 1.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 KOO27084.1 - 1.1e-06 27.9 0.2 1.3e-06 27.6 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 KOO27084.1 - 7.7e-05 22.6 0.1 0.00017 21.5 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 KOO27084.1 - 0.00016 20.9 0.0 0.00023 20.4 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.1 KOO27084.1 - 0.00043 20.4 0.0 0.00063 19.8 0.0 1.3 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 KOO27084.1 - 0.0021 17.2 0.0 0.0039 16.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 cobW PF02492.14 KOO27084.1 - 0.028 13.8 0.5 4 6.8 0.1 2.2 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.22 KOO27084.1 - 0.035 14.4 0.1 0.054 13.7 0.0 1.6 1 1 0 1 1 1 0 ABC transporter FeoB_N PF02421.13 KOO27084.1 - 0.048 12.9 0.0 0.29 10.3 0.0 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_16 PF13191.1 KOO27084.1 - 0.05 13.5 0.1 0.1 12.5 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.7 KOO27084.1 - 0.059 13.0 0.0 0.096 12.3 0.0 1.3 1 0 0 1 1 1 0 NACHT domain ATP_bind_1 PF03029.12 KOO27084.1 - 0.072 12.6 0.0 0.18 11.3 0.0 1.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_29 PF13555.1 KOO27084.1 - 0.079 12.4 0.2 0.39 10.2 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain AMP-binding PF00501.23 KOO27085.1 - 1.3e-53 181.9 0.0 1.8e-53 181.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 KOO27085.1 - 4.9e-07 30.5 0.1 1.7e-06 28.9 0.0 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain GH3 PF03321.8 KOO27085.1 - 0.11 10.9 0.0 0.39 9.1 0.0 1.7 2 0 0 2 2 2 0 GH3 auxin-responsive promoter EF-hand_6 PF13405.1 KOO27086.1 - 2.4e-08 33.1 0.8 0.0037 17.0 0.1 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.27 KOO27086.1 - 1.6e-07 30.0 3.4 0.00032 19.7 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 KOO27086.1 - 2.1e-07 30.9 0.0 9.5e-05 22.4 0.0 2.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO27086.1 - 3e-06 26.7 0.8 3e-05 23.5 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO27086.1 - 0.0052 16.0 4.1 0.017 14.4 0.2 2.9 3 0 0 3 3 3 1 EF hand RNase_H2-Ydr279 PF09468.5 KOO27086.1 - 0.48 9.5 4.7 0.7 9.0 3.3 1.3 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Asp-B-Hydro_N PF05279.6 KOO27086.1 - 2.6 7.8 16.2 0.37 10.6 8.2 1.6 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region SelR PF01641.13 KOO27089.1 - 1.2e-05 25.0 0.0 2.8e-05 23.8 0.0 1.6 1 1 0 1 1 1 1 SelR domain zf-CW PF07496.10 KOO27090.1 - 4.7e-10 39.0 3.5 1.2e-09 37.7 2.4 1.7 1 0 0 1 1 1 1 CW-type Zinc Finger Gal4_dimer PF03902.8 KOO27090.1 - 0.038 13.9 0.1 0.078 12.9 0.1 1.4 1 0 0 1 1 1 0 Gal4-like dimerisation domain DUF4479 PF14794.1 KOO27090.1 - 0.2 11.1 0.0 0.38 10.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4479) FAD_binding_3 PF01494.14 KOO27091.1 - 9.4e-18 64.3 1.8 1e-14 54.3 0.8 2.9 2 1 0 2 2 2 1 FAD binding domain FAD_binding_2 PF00890.19 KOO27091.1 - 2.6e-05 23.2 0.9 6.3e-05 22.0 0.6 1.6 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 KOO27091.1 - 4.4e-05 23.4 1.2 0.00019 21.3 0.2 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 KOO27091.1 - 0.0022 16.5 0.4 0.004 15.6 0.3 1.4 1 0 0 1 1 1 1 HI0933-like protein GIDA PF01134.17 KOO27091.1 - 0.0092 14.8 0.7 0.013 14.3 0.5 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A DAO PF01266.19 KOO27091.1 - 0.012 14.5 4.9 0.021 13.7 0.4 2.5 2 1 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 KOO27091.1 - 0.029 14.2 0.3 0.054 13.3 0.2 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 KOO27091.1 - 0.034 13.2 1.4 0.054 12.5 0.9 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.22 KOO27091.1 - 0.073 13.4 0.1 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 KOO27091.1 - 0.088 11.8 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pkinase PF00069.20 KOO27092.1 - 1.9e-23 82.9 0.0 3.1e-23 82.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27092.1 - 1.2e-15 57.2 0.0 1.9e-15 56.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1499 PF07386.6 KOO27093.1 - 6.8e-16 58.5 0.0 1.3e-15 57.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1499) CPSase_L_D3 PF02787.14 KOO27093.1 - 0.049 13.4 0.0 0.084 12.6 0.0 1.3 1 0 0 1 1 1 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain TAT_signal PF10518.4 KOO27093.1 - 0.46 10.6 5.9 0.13 12.3 1.8 1.9 2 0 0 2 2 2 0 TAT (twin-arginine translocation) pathway signal sequence EF-hand_1 PF00036.27 KOO27094.1 - 3.2e-86 276.2 71.3 3.3e-05 22.8 0.1 18.8 19 0 0 19 19 19 18 EF hand EF-hand_6 PF13405.1 KOO27094.1 - 1.5e-81 261.0 61.2 3e-05 23.5 0.0 18.5 18 0 0 18 18 18 18 EF-hand domain EF-hand_7 PF13499.1 KOO27094.1 - 5.4e-74 244.2 57.3 8.1e-09 35.4 0.5 11.7 7 4 3 11 11 11 11 EF-hand domain pair EF-hand_5 PF13202.1 KOO27094.1 - 1.1e-58 192.1 80.9 0.00057 19.1 0.2 18.5 18 0 0 18 18 18 17 EF hand EF-hand_8 PF13833.1 KOO27094.1 - 4.8e-56 186.2 80.9 9e-06 25.2 0.2 17.1 7 5 10 17 17 17 17 EF-hand domain pair EF-hand_10 PF14788.1 KOO27094.1 - 5.2e-13 48.4 26.3 0.29 10.8 0.0 13.2 12 2 2 14 14 14 4 EF hand SPARC_Ca_bdg PF10591.4 KOO27094.1 - 1.9e-08 34.2 23.2 0.41 10.7 0.1 9.8 9 3 1 12 12 12 4 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO27094.1 - 1.9e-07 30.7 39.4 0.036 13.7 0.3 10.2 8 3 2 11 11 11 3 Cytoskeletal-regulatory complex EF hand Armet PF10208.4 KOO27094.1 - 0.0026 17.4 1.3 17 5.0 0.0 5.6 6 0 0 6 6 6 0 Degradation arginine-rich protein for mis-folding DUF3872 PF12988.2 KOO27094.1 - 0.015 14.7 0.4 5.3 6.5 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function, B. Theta Gene description (DUF3872) DUF4487 PF14868.1 KOO27094.1 - 0.64 8.6 0.1 39 2.7 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4487) Vint PF14623.1 KOO27095.1 - 1.2e-32 112.5 0.0 2.3e-32 111.7 0.0 1.4 1 0 0 1 1 1 1 Hint-domain VWA_2 PF13519.1 KOO27095.1 - 8e-10 39.0 0.0 1.3e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Vwaint PF14624.1 KOO27095.1 - 0.00012 22.0 0.0 0.00022 21.2 0.0 1.4 1 0 0 1 1 1 1 VWA / Hh protein intein-like VWA PF00092.23 KOO27095.1 - 0.043 13.5 0.0 0.1 12.3 0.0 1.6 1 1 0 1 1 1 0 von Willebrand factor type A domain DUF4486 PF14858.1 KOO27096.1 - 0.0097 14.2 0.6 0.018 13.2 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4486) DUF4618 PF15397.1 KOO27096.1 - 0.91 8.8 6.0 1 8.6 1.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) EGF_2 PF07974.8 KOO27098.1 - 1e-28 99.1 201.3 0.00016 21.7 5.3 11.3 11 0 0 11 11 11 11 EGF-like domain hEGF PF12661.2 KOO27098.1 - 1.2e-11 43.8 89.1 0.0014 18.6 1.4 11.3 10 0 0 10 10 10 8 Human growth factor-like EGF EGF PF00008.22 KOO27098.1 - 4.3e-10 39.3 160.4 0.0006 19.7 3.7 11.9 11 1 0 11 11 11 8 EGF-like domain Bim_N PF06773.6 KOO27098.1 - 1.2 8.9 5.8 0.25 11.0 0.2 2.8 2 0 0 2 2 2 0 Bim protein N-terminus Cofilin_ADF PF00241.15 KOO27099.1 - 2.7e-24 85.4 0.0 3.5e-13 49.5 0.0 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein PCIF1_WW PF12237.3 KOO27100.1 - 2e-50 170.5 0.0 3.2e-50 169.8 0.0 1.3 1 0 0 1 1 1 1 Phosphorylated CTD interacting factor 1 WW domain UAA PF08449.6 KOO27101.1 - 2.6e-08 33.1 21.7 3.4e-08 32.7 5.8 2.1 2 0 0 2 2 2 2 UAA transporter family TPT PF03151.11 KOO27101.1 - 2.9e-06 27.0 10.4 2.9e-06 27.0 7.2 3.1 1 1 1 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 KOO27101.1 - 0.0023 17.9 4.4 0.0023 17.9 3.0 2.9 1 1 0 2 2 2 1 EamA-like transporter family Inositol_P PF00459.20 KOO27102.1 - 1.2e-44 152.6 0.0 2e-44 151.9 0.0 1.2 1 0 0 1 1 1 1 Inositol monophosphatase family GxGYxYP PF14323.1 KOO27102.1 - 1.3e-22 80.1 0.0 2.2e-22 79.4 0.0 1.3 1 0 0 1 1 1 1 GxGYxY sequence motif in domain of unknown function Caps_synth PF05704.7 KOO27102.1 - 2.5e-10 40.0 0.0 4.8e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.10 KOO27102.1 - 0.00076 19.8 0.0 0.0017 18.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif DUF2198 PF09964.4 KOO27102.1 - 0.16 11.7 0.9 2 8.2 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2198) DUF1664 PF07889.7 KOO27103.1 - 0.11 12.2 0.9 0.16 11.7 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF445 PF04286.7 KOO27103.1 - 0.14 11.6 1.4 0.19 11.2 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) RCC_reductase PF06405.6 KOO27105.1 - 0.059 12.3 0.0 0.43 9.4 0.0 1.9 2 0 0 2 2 2 0 Red chlorophyll catabolite reductase (RCC reductase) DUF1612 PF07756.7 KOO27105.1 - 0.11 12.6 0.1 1.2 9.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1612) WGR PF05406.10 KOO27106.1 - 6e-23 80.6 0.7 1.2e-22 79.6 0.5 1.5 1 0 0 1 1 1 1 WGR domain Ank PF00023.25 KOO27106.1 - 9.9e-09 34.5 0.1 9.8e-06 25.1 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 KOO27106.1 - 1.7e-08 34.7 0.0 0.00032 21.1 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO27106.1 - 3e-08 33.8 0.0 8.7e-08 32.4 0.0 1.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO27106.1 - 4.9e-08 32.9 0.0 1.1e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO27106.1 - 8e-05 22.5 0.0 0.0011 18.9 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat PDEase_I PF00233.14 KOO27107.1 - 6e-58 196.3 0.0 7.9e-58 195.9 0.0 1.1 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase YL1 PF05764.8 KOO27108.1 - 0.064 12.8 2.2 0.076 12.6 1.6 1.0 1 0 0 1 1 1 0 YL1 nuclear protein Aldo_ket_red PF00248.16 KOO27112.1 - 2.3e-36 125.0 0.0 3.6e-36 124.4 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Vasohibin PF14822.1 KOO27113.1 - 9.7e-68 227.9 0.0 1.7e-67 227.1 0.0 1.3 1 0 0 1 1 1 1 Vasohibin EF-hand_1 PF00036.27 KOO27114.1 - 4.3e-08 31.8 0.1 0.0066 15.6 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO27114.1 - 1.2e-06 28.4 0.6 5.2e-06 26.5 0.4 2.1 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO27114.1 - 5.8e-06 25.8 1.5 0.12 12.0 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO27114.1 - 1.8e-05 23.8 0.1 0.011 15.0 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO27114.1 - 1.8e-05 24.2 0.2 0.0062 16.3 0.0 2.8 2 0 0 2 2 2 1 EF-hand domain TPR_2 PF07719.12 KOO27114.1 - 0.016 15.1 23.0 0.1 12.5 0.4 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.1 KOO27114.1 - 0.097 12.3 13.8 0.36 10.5 0.0 4.7 4 1 0 4 4 4 0 TPR repeat EF-hand_4 PF12763.2 KOO27114.1 - 0.16 11.6 0.3 2.2 8.0 0.0 2.3 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand TPR_6 PF13174.1 KOO27114.1 - 0.19 12.2 7.4 0.99 10.0 0.1 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOO27114.1 - 0.3 10.9 8.7 0.55 10.1 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Baculo_PEP_C PF04513.7 KOO27115.1 - 0.36 10.6 9.5 6.2 6.6 0.2 4.2 4 1 1 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus SIR2 PF02146.12 KOO27118.1 - 9.8e-24 84.0 0.0 1.2e-23 83.7 0.0 1.1 1 0 0 1 1 1 1 Sir2 family DUF2383 PF09537.5 KOO27119.1 - 0.036 14.3 0.2 0.042 14.0 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) DUF883 PF05957.8 KOO27121.1 - 7.2 7.0 10.2 0.51 10.7 1.6 2.4 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF1116 PF06545.6 KOO27122.1 - 5e-70 234.9 0.0 7.5e-70 234.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1116) Isochorismatase PF00857.15 KOO27122.1 - 4.9e-37 127.5 0.0 9.4e-37 126.6 0.0 1.4 1 0 0 1 1 1 1 Isochorismatase family DUF872 PF05915.7 KOO27123.1 - 0.0026 17.5 0.5 0.0077 16.0 0.4 1.7 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) Pkinase PF00069.20 KOO27125.1 - 1.3e-53 181.8 0.0 1.5e-53 181.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27125.1 - 1.7e-18 66.6 0.0 2.2e-18 66.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO27125.1 - 1.3e-09 37.4 0.2 0.00025 20.1 0.0 2.9 1 1 1 2 2 2 2 Kinase-like APH PF01636.18 KOO27125.1 - 2e-06 27.7 3.1 4.9e-06 26.4 0.2 2.7 2 1 0 2 2 2 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 KOO27125.1 - 0.0002 20.7 0.0 0.00034 20.0 0.0 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Choline_kinase PF01633.15 KOO27125.1 - 0.005 16.4 0.0 0.0072 15.9 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.9 KOO27125.1 - 0.028 13.4 0.0 0.044 12.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Phage_GP20 PF06810.6 KOO27126.1 - 0.0037 16.7 3.3 0.0037 16.7 2.3 2.4 3 0 0 3 3 3 1 Phage minor structural protein GP20 TMF_TATA_bd PF12325.3 KOO27126.1 - 0.0087 15.7 7.4 0.0087 15.7 5.1 3.6 2 1 1 3 3 3 2 TATA element modulatory factor 1 TATA binding CENP-F_leu_zip PF10473.4 KOO27126.1 - 0.017 14.9 23.9 0.3 10.9 3.2 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Ion_trans PF00520.26 KOO27126.1 - 0.022 13.9 0.2 0.033 13.4 0.2 1.2 1 0 0 1 1 1 0 Ion transport protein GAS PF13851.1 KOO27126.1 - 0.15 11.2 21.0 0.033 13.3 8.9 2.6 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.6 KOO27126.1 - 0.2 10.2 18.2 0.82 8.2 1.3 2.5 2 1 0 2 2 2 0 Spc7 kinetochore protein CDC37_N PF03234.9 KOO27126.1 - 2.7 8.2 10.2 1.4 9.2 2.0 2.4 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding Fzo_mitofusin PF04799.8 KOO27126.1 - 5.6 6.3 9.7 6.1 6.1 1.7 2.4 2 0 0 2 2 2 0 fzo-like conserved region DUF2968 PF11180.3 KOO27126.1 - 8.4 5.7 39.8 0.041 13.2 4.3 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2968) TMF_DNA_bd PF12329.3 KOO27126.1 - 9.2 6.1 20.7 0.042 13.6 4.1 3.8 2 2 1 3 3 3 0 TATA element modulatory factor 1 DNA binding TCTP PF00838.12 KOO27127.1 - 1.2e-10 41.6 0.0 9.5e-10 38.7 0.0 2.4 1 1 0 1 1 1 1 Translationally controlled tumour protein AP2 PF00847.15 KOO27129.1 - 4.8e-11 42.6 5.9 3.9e-05 23.7 0.1 3.3 2 1 1 3 3 3 2 AP2 domain zf-MIZ PF02891.15 KOO27129.1 - 0.0005 19.5 2.6 0.00066 19.1 1.0 1.8 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-Nse PF11789.3 KOO27129.1 - 0.44 10.0 2.7 1.5 8.4 1.9 1.9 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DivIC PF04977.10 KOO27130.1 - 0.071 12.6 0.7 0.19 11.2 0.5 1.8 1 0 0 1 1 1 0 Septum formation initiator PPR_3 PF13812.1 KOO27131.1 - 4.7e-38 126.2 18.5 2.1e-05 24.4 0.1 10.2 11 0 0 11 11 11 8 Pentatricopeptide repeat domain PPR_2 PF13041.1 KOO27131.1 - 3.2e-34 116.6 0.0 1.5e-05 24.9 0.0 8.3 3 3 6 9 9 9 9 PPR repeat family PPR PF01535.15 KOO27131.1 - 6.9e-28 94.6 2.0 0.0013 18.5 0.0 10.1 12 0 0 12 12 12 6 PPR repeat PPR_1 PF12854.2 KOO27131.1 - 1.5e-14 53.1 1.1 0.063 12.7 0.0 8.9 9 1 1 10 10 10 3 PPR repeat Apc3 PF12895.2 KOO27131.1 - 1.9e-07 31.0 4.7 0.00081 19.4 0.5 4.4 3 2 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 KOO27131.1 - 8.7e-06 25.9 24.3 0.24 12.1 0.7 7.2 4 1 4 8 8 7 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO27131.1 - 8.9e-05 23.0 22.4 0.028 15.1 0.5 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO27131.1 - 0.00024 21.4 14.5 1.1 9.6 0.1 5.4 5 1 2 7 7 7 2 Tetratricopeptide repeat COX5A PF02284.11 KOO27131.1 - 0.027 14.3 0.1 2.4 8.1 0.0 2.7 2 0 0 2 2 2 0 Cytochrome c oxidase subunit Va TPR_12 PF13424.1 KOO27131.1 - 0.074 12.9 10.5 2 8.3 0.1 5.0 5 2 1 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO27131.1 - 0.12 12.2 8.2 13 5.9 0.1 6.0 6 1 0 6 6 6 0 Tetratricopeptide repeat ECSIT PF06239.6 KOO27131.1 - 0.12 11.1 0.0 11 4.8 0.0 3.3 4 1 1 5 5 5 0 Evolutionarily conserved signalling intermediate in Toll pathway TPR_15 PF13429.1 KOO27131.1 - 0.17 10.9 3.7 1.9 7.4 0.0 2.9 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 KOO27131.1 - 1.3 9.0 12.1 19 5.3 0.2 5.9 7 0 0 7 7 7 0 Tetratricopeptide repeat AP2 PF00847.15 KOO27132.1 - 3e-15 56.1 40.1 1.3e-06 28.4 0.2 6.2 7 0 0 7 7 7 4 AP2 domain IF3_N PF05198.11 KOO27132.1 - 0.00054 19.8 1.0 0.94 9.4 0.1 3.3 3 0 0 3 3 3 2 Translation initiation factor IF-3, N-terminal domain AbrB-like PF14250.1 KOO27132.1 - 9.3 6.2 6.3 28 4.7 0.2 3.5 4 0 0 4 4 4 0 AbrB-like transcriptional regulator TRAM_LAG1_CLN8 PF03798.11 KOO27133.1 - 8.8e-18 64.5 18.5 1.1e-17 64.2 12.8 1.1 1 0 0 1 1 1 1 TLC domain Ribosomal_L37 PF08561.5 KOO27134.1 - 3.2e-17 61.8 0.0 5e-17 61.2 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 Dymeclin PF09742.4 KOO27135.1 - 1.7e-105 353.6 0.0 1.4e-104 350.6 0.0 1.9 1 1 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.2 KOO27135.1 - 0.0026 15.5 0.0 0.0079 13.9 0.0 1.7 2 0 0 2 2 2 1 High-temperature-induced dauer-formation protein SRP1_TIP1 PF00660.12 KOO27135.1 - 0.12 12.2 0.0 0.29 10.9 0.0 1.6 1 0 0 1 1 1 0 Seripauperin and TIP1 family ISG65-75 PF11727.3 KOO27136.1 - 0.054 12.5 4.5 0.077 12.0 3.1 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein AHS1 PF02682.11 KOO27136.1 - 0.13 11.7 0.9 0.22 10.9 0.6 1.3 1 0 0 1 1 1 0 Allophanate hydrolase subunit 1 RRN3 PF05327.6 KOO27136.1 - 0.36 8.8 3.5 0.48 8.4 2.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF1682 PF07946.9 KOO27136.1 - 0.37 9.6 2.0 0.63 8.8 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) SseC PF04888.7 KOO27136.1 - 2.4 7.4 5.5 4 6.6 3.8 1.3 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Ribosomal_S9 PF00380.14 KOO27138.1 - 4e-36 123.9 0.1 4.6e-36 123.7 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ank_2 PF12796.2 KOO27139.1 - 1e-14 54.6 0.0 2.1e-07 31.1 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO27139.1 - 5.3e-09 35.4 0.3 3e-05 23.5 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 KOO27139.1 - 2.9e-05 23.8 0.1 0.078 13.2 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.1 KOO27139.1 - 6.4e-05 23.0 0.1 0.0013 18.8 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO27139.1 - 0.006 17.0 0.1 0.17 12.4 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Pex16 PF08610.5 KOO27140.1 - 0.021 13.8 0.0 0.023 13.6 0.0 1.1 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) BRF1 PF07741.8 KOO27140.1 - 0.33 11.1 5.4 0.53 10.5 3.7 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Fcf1 PF04900.7 KOO27141.1 - 8.3e-15 54.7 0.0 1.8e-14 53.6 0.0 1.6 1 0 0 1 1 1 1 Fcf1 PGAP1 PF07819.8 KOO27141.1 - 1.8e-08 34.2 0.0 2.9e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_5 PF12695.2 KOO27141.1 - 9.4e-06 25.4 0.2 2.3e-05 24.2 0.1 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO27141.1 - 1e-05 25.5 4.2 1e-05 25.5 2.9 2.2 2 1 0 2 2 2 1 Alpha/beta hydrolase family LCAT PF02450.10 KOO27141.1 - 0.0004 19.4 0.0 0.00063 18.8 0.0 1.2 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase His_Phos_1 PF00300.17 KOO27141.1 - 0.059 13.4 0.0 0.64 10.0 0.0 2.2 2 0 0 2 2 2 0 Histidine phosphatase superfamily (branch 1) DUF676 PF05057.9 KOO27141.1 - 0.077 12.2 0.1 0.47 9.7 0.0 2.2 3 0 0 3 3 3 0 Putative serine esterase (DUF676) Lipase_3 PF01764.20 KOO27141.1 - 0.078 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) GST_N PF02798.15 KOO27142.1 - 2.5e-13 49.9 0.0 6.9e-13 48.5 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 KOO27142.1 - 3.1e-06 27.2 0.0 6.1e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 KOO27142.1 - 5.2e-05 23.1 0.1 0.002 18.0 0.0 2.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 KOO27142.1 - 0.00016 21.5 0.0 0.00032 20.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain PC_rep PF01851.17 KOO27144.1 - 0.0081 16.3 1.9 3.1 8.2 0.0 3.4 3 0 0 3 3 3 2 Proteasome/cyclosome repeat TIMELESS_C PF05029.8 KOO27145.1 - 1.9 7.3 11.6 1.9 7.3 8.1 1.0 1 0 0 1 1 1 0 Timeless protein C terminal region YL1 PF05764.8 KOO27145.1 - 3.8 7.0 10.8 3.9 7.0 7.5 1.0 1 0 0 1 1 1 0 YL1 nuclear protein Nuc_sug_transp PF04142.10 KOO27146.1 - 7.3e-50 169.3 5.1 9.8e-50 168.9 3.5 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.6 KOO27146.1 - 3.4e-08 32.7 7.7 4.5e-08 32.3 5.4 1.3 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 KOO27146.1 - 3.3e-07 30.0 10.9 2.3e-06 27.3 1.6 3.2 2 1 0 2 2 2 1 Triose-phosphate Transporter family EmrE PF13536.1 KOO27146.1 - 0.0001 22.4 12.0 0.00037 20.6 1.7 2.5 2 0 0 2 2 2 2 Multidrug resistance efflux transporter EamA PF00892.15 KOO27146.1 - 0.00061 19.8 3.8 0.00061 19.8 2.6 2.8 3 1 0 3 3 3 1 EamA-like transporter family DUF914 PF06027.7 KOO27146.1 - 0.011 14.6 1.0 0.015 14.1 0.1 1.5 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF914) NHL PF01436.16 KOO27147.1 - 2.1e-24 84.1 23.4 1.3e-06 28.0 0.2 7.1 7 2 1 8 8 8 5 NHL repeat BTB PF00651.26 KOO27147.1 - 1.3e-11 44.4 0.0 3.5e-11 43.0 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain SGL PF08450.7 KOO27147.1 - 5.4e-11 42.3 0.1 0.0031 16.9 0.0 4.4 3 1 2 5 5 5 2 SMP-30/Gluconolaconase/LRE-like region NOG1 PF06858.9 KOO27147.1 - 0.00077 19.2 0.0 0.17 11.7 0.0 2.5 2 0 0 2 2 2 1 Nucleolar GTP-binding protein 1 (NOG1) PQQ_3 PF13570.1 KOO27147.1 - 0.0031 17.7 10.4 3.9 7.8 0.2 5.2 5 0 0 5 5 5 2 PQQ-like domain Ldl_recept_b PF00058.12 KOO27147.1 - 0.098 12.9 0.0 1e+02 3.3 0.0 4.4 5 0 0 5 5 5 0 Low-density lipoprotein receptor repeat class B NAD_binding_10 PF13460.1 KOO27149.1 - 4.6e-20 72.3 1.8 1.1e-16 61.3 1.3 3.1 1 1 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 KOO27149.1 - 0.007 15.6 0.0 0.028 13.6 0.0 1.9 1 1 0 1 1 1 1 NmrA-like family DAHP_synth_2 PF01474.11 KOO27150.1 - 8.3e-147 489.0 0.0 1.4e-146 488.2 0.0 1.3 1 1 0 1 1 1 1 Class-II DAHP synthetase family E1-E2_ATPase PF00122.15 KOO27151.1 - 6.8e-12 44.9 0.0 9.7e-12 44.4 0.0 1.3 1 0 0 1 1 1 1 E1-E2 ATPase HAD PF12710.2 KOO27151.1 - 0.019 15.1 0.1 0.029 14.5 0.1 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF4413 PF14372.1 KOO27151.1 - 0.11 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) LRR_6 PF13516.1 KOO27152.1 - 0.00012 21.7 2.6 0.055 13.5 0.1 3.6 3 0 0 3 3 3 2 Leucine Rich repeat LRR_7 PF13504.1 KOO27152.1 - 0.12 12.6 2.0 20 5.9 0.1 4.3 5 0 0 5 5 5 0 Leucine rich repeat Glycos_transf_2 PF00535.21 KOO27153.1 - 2.6e-15 56.5 0.0 4.5e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 KOO27153.1 - 1.7e-08 34.5 0.5 4.3e-08 33.2 0.4 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.1 KOO27153.1 - 0.0052 17.0 0.0 0.011 15.9 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 LRR_6 PF13516.1 KOO27154.1 - 6.4e-32 106.0 29.4 0.00029 20.5 0.0 11.9 11 0 0 11 11 11 10 Leucine Rich repeat LRR_4 PF12799.2 KOO27154.1 - 2.1e-14 52.7 16.1 0.0087 15.6 0.2 7.1 5 2 3 8 8 8 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO27154.1 - 6.7e-10 37.6 0.2 11 6.5 0.0 8.7 8 0 0 8 8 8 1 Leucine Rich Repeat LRR_8 PF13855.1 KOO27154.1 - 7.6e-10 38.4 15.8 0.031 14.0 1.6 6.2 4 1 1 5 5 5 3 Leucine rich repeat LRR_7 PF13504.1 KOO27154.1 - 7.7e-05 22.2 20.4 23 5.7 0.0 9.3 9 0 0 9 9 9 1 Leucine rich repeat YojJ PF10372.4 KOO27154.1 - 0.043 13.6 1.0 12 5.8 0.0 3.4 3 0 0 3 3 3 0 Bacterial membrane-spanning protein N-terminus WW PF00397.21 KOO27155.1 - 8e-11 41.5 1.1 1.5e-10 40.7 0.7 1.5 1 0 0 1 1 1 1 WW domain SSF PF00474.12 KOO27156.1 - 2.1e-21 76.0 21.8 2e-15 56.3 8.5 2.2 2 0 0 2 2 2 2 Sodium:solute symporter family DAO PF01266.19 KOO27157.1 - 9e-61 205.7 0.1 1.2e-60 205.2 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Fer2_BFD PF04324.10 KOO27157.1 - 3.4e-07 30.2 2.4 3.4e-07 30.2 1.7 2.3 2 0 0 2 2 2 1 BFD-like [2Fe-2S] binding domain NAD_binding_8 PF13450.1 KOO27157.1 - 0.00015 21.7 0.6 0.00035 20.5 0.2 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 KOO27157.1 - 0.00067 18.6 0.8 0.0031 16.4 0.3 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein TrkA_N PF02254.13 KOO27157.1 - 0.0053 16.7 0.1 0.019 14.9 0.1 2.0 1 0 0 1 1 1 1 TrkA-N domain Thi4 PF01946.12 KOO27157.1 - 0.016 14.3 0.3 0.034 13.2 0.2 1.5 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.9 KOO27157.1 - 0.02 14.7 0.2 0.045 13.6 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 KOO27157.1 - 0.023 13.7 1.1 0.092 11.7 0.2 2.1 2 0 0 2 2 2 0 FAD binding domain HI0933_like PF03486.9 KOO27157.1 - 0.045 12.2 0.2 0.073 11.5 0.2 1.3 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.22 KOO27157.1 - 0.066 13.6 0.3 0.2 12.0 0.2 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 KOO27157.1 - 0.076 12.6 0.4 0.15 11.6 0.2 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.11 KOO27157.1 - 0.081 12.3 0.5 0.15 11.4 0.4 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Saccharop_dh PF03435.13 KOO27157.1 - 0.14 11.0 0.2 0.24 10.3 0.1 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase Dynein_heavy PF03028.10 KOO27158.1 - 8.4e-203 675.3 0.0 2.4e-202 673.8 0.0 1.7 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor AAA_8 PF12780.2 KOO27158.1 - 1.8e-108 361.5 0.0 3.9e-108 360.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 DHC_N2 PF08393.8 KOO27158.1 - 1.2e-104 350.0 5.9 1.2e-104 350.0 4.1 2.6 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_7 PF12775.2 KOO27158.1 - 4.1e-90 301.5 0.6 7.2e-90 300.7 0.4 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_6 PF12774.2 KOO27158.1 - 3e-87 291.9 0.0 6.8e-87 290.8 0.0 1.6 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_9 PF12781.2 KOO27158.1 - 1.4e-78 262.8 1.1 2.6e-78 261.9 0.2 2.0 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 MT PF12777.2 KOO27158.1 - 5e-62 209.6 10.7 5e-62 209.6 7.4 1.6 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.9 KOO27158.1 - 1.5e-17 63.6 0.0 2e-05 24.3 0.0 5.3 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) AAA PF00004.24 KOO27158.1 - 0.0028 17.8 0.6 9.9 6.3 0.0 4.1 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO27158.1 - 0.0093 15.9 11.1 0.47 10.4 0.0 5.4 6 0 0 6 6 6 1 AAA ATPase domain PSI_PsaF PF02507.10 KOO27159.1 - 0.14 11.7 1.7 0.29 10.6 1.2 1.5 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III AA_kinase PF00696.23 KOO27159.1 - 0.27 10.7 1.0 2.9 7.3 0.0 2.2 2 0 0 2 2 2 0 Amino acid kinase family LRR_5 PF13306.1 KOO27160.1 - 3.3e-18 65.6 0.0 3.8e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO27160.1 - 2.9e-05 23.7 0.0 0.0011 18.7 0.0 2.4 1 1 1 2 2 2 1 Leucine rich repeat DHC_N1 PF08385.7 KOO27161.1 - 4.2e-129 431.5 1.0 2.3e-125 419.2 0.0 3.1 3 1 0 3 3 3 2 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.8 KOO27161.1 - 1.6e-109 366.1 2.6 1.6e-109 366.1 1.8 3.8 5 0 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 KOO27161.1 - 6.8e-99 330.0 0.0 1.1e-98 329.3 0.0 1.3 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_7 PF12775.2 KOO27161.1 - 8.5e-19 67.6 0.0 2.5e-18 66.1 0.0 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_5 PF07728.9 KOO27161.1 - 6.1e-14 51.9 0.0 0.0025 17.5 0.0 4.3 3 1 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOO27161.1 - 8e-06 25.9 1.5 0.23 11.4 0.0 3.9 3 1 0 3 3 3 2 AAA ATPase domain AAA PF00004.24 KOO27161.1 - 2e-05 24.8 0.0 0.31 11.2 0.0 3.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 KOO27161.1 - 0.00011 22.0 0.0 0.82 9.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 KOO27161.1 - 0.00065 19.8 0.0 0.6 10.2 0.0 3.2 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KOO27161.1 - 0.00095 18.8 0.1 0.23 11.2 0.1 2.7 2 0 0 2 2 2 1 Part of AAA domain AAA_18 PF13238.1 KOO27161.1 - 0.009 16.3 0.0 7 6.9 0.0 3.9 3 0 0 3 3 3 1 AAA domain DUF1376 PF07120.6 KOO27161.1 - 0.017 15.1 1.1 0.15 12.2 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1376) AAA_17 PF13207.1 KOO27161.1 - 0.02 15.7 0.2 0.5 11.1 0.0 3.4 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.17 KOO27161.1 - 0.24 11.6 2.1 4.1 7.6 0.0 4.0 5 0 0 5 5 5 0 RNA helicase DUF4423 PF14394.1 KOO27163.1 - 0.027 14.0 4.3 13 5.2 0.0 4.2 3 1 1 4 4 4 0 Domain of unknown function (DUF4423) Pepsin-I3 PF06394.8 KOO27164.1 - 0.039 13.6 6.8 2.1 8.0 0.1 3.7 4 0 0 4 4 4 0 Pepsin inhibitor-3-like repeated domain HA PF03457.9 KOO27164.1 - 0.059 13.4 9.9 2.1 8.5 0.1 3.9 4 0 0 4 4 4 0 Helicase associated domain zf-HC2 PF13490.1 KOO27164.1 - 1 9.3 8.9 46 4.0 0.1 4.3 4 0 0 4 4 4 0 Putative zinc-finger PspB PF06667.7 KOO27164.1 - 1.1 9.2 13.6 7.5 6.5 0.1 4.5 4 0 0 4 4 4 0 Phage shock protein B DUF896 PF05979.7 KOO27164.1 - 4 7.1 15.8 1.3 8.6 1.3 3.5 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF896) SHOCT PF09851.4 KOO27164.1 - 5.8 6.5 13.3 1.6 8.2 0.6 4.2 3 1 1 4 4 4 0 Short C-terminal domain CTP_synth_N PF06418.9 KOO27167.1 - 1.2e-123 411.5 0.0 1.6e-123 411.1 0.0 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.23 KOO27167.1 - 8.7e-52 175.3 0.0 1.5e-51 174.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 KOO27167.1 - 3.1e-06 26.7 0.0 9.6e-06 25.1 0.0 1.9 1 1 0 1 1 1 1 Peptidase C26 CbiA PF01656.18 KOO27167.1 - 9.9e-05 21.8 0.0 0.00016 21.1 0.0 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain DUF2721 PF11026.3 KOO27168.1 - 0.066 12.8 0.2 0.066 12.8 0.1 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF2721) SieB PF14163.1 KOO27168.1 - 4.1 6.9 6.4 7.7 6.0 0.8 2.7 1 1 1 2 2 2 0 Superinfection exclusion protein B FAD_binding_3 PF01494.14 KOO27171.1 - 0.0031 16.6 0.4 0.0042 16.1 0.3 1.3 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 KOO27171.1 - 0.0061 16.5 0.2 0.026 14.5 0.1 2.3 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 KOO27171.1 - 0.0084 15.8 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 KOO27171.1 - 0.011 15.5 0.8 0.028 14.2 0.1 2.1 3 1 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.18 KOO27171.1 - 0.022 14.4 0.6 0.11 12.1 0.4 2.1 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UDPG_MGDP_dh_N PF03721.9 KOO27171.1 - 0.031 13.6 0.0 0.046 13.0 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain HI0933_like PF03486.9 KOO27171.1 - 0.034 12.6 0.1 0.049 12.0 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.12 KOO27171.1 - 0.11 11.6 0.1 0.24 10.4 0.1 1.5 1 0 0 1 1 1 0 Thi4 family T2SE_Nter PF05157.10 KOO27173.1 - 0.014 15.3 0.1 0.36 10.8 0.1 2.5 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein E, N-terminal domain Kelch_5 PF13854.1 KOO27173.1 - 0.084 12.8 0.2 0.2 11.6 0.0 1.7 2 0 0 2 2 2 0 Kelch motif TylF PF05711.6 KOO27174.1 - 5e-30 104.4 0.0 9.6e-30 103.4 0.0 1.4 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Cupin_8 PF13621.1 KOO27174.1 - 5.4e-10 39.1 0.0 1.4e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 Cupin-like domain Methyltransf_24 PF13578.1 KOO27174.1 - 9.3e-06 26.4 0.0 7.2e-05 23.5 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain JmjC PF02373.17 KOO27174.1 - 0.017 15.3 0.0 0.071 13.3 0.0 2.1 1 1 0 1 1 1 0 JmjC domain, hydroxylase ABC_tran PF00005.22 KOO27175.1 - 2.7e-34 118.4 0.0 4.6e-34 117.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 KOO27175.1 - 6.2e-34 117.6 2.6 8.3e-34 117.2 1.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.14 KOO27175.1 - 1.2e-07 31.2 0.2 1.7e-05 24.1 0.1 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 KOO27175.1 - 5.3e-06 26.5 0.2 0.0021 18.1 0.0 2.1 1 1 0 2 2 2 1 AAA domain AAA_25 PF13481.1 KOO27175.1 - 0.00033 20.0 0.1 0.00085 18.7 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOO27175.1 - 0.00049 20.1 0.6 0.00049 20.1 0.4 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.1 KOO27175.1 - 0.0011 18.4 0.1 0.0023 17.4 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_ATPase PF09818.4 KOO27175.1 - 0.002 16.7 0.4 0.012 14.2 0.1 2.0 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_19 PF13245.1 KOO27175.1 - 0.0046 16.6 4.2 0.015 15.0 0.2 3.1 2 1 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 KOO27175.1 - 0.018 14.6 0.5 2.4 7.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.1 KOO27175.1 - 0.028 14.3 1.9 0.1 12.5 0.3 2.7 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_17 PF13207.1 KOO27175.1 - 0.066 14.0 0.1 0.14 13.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_10 PF12846.2 KOO27175.1 - 0.067 12.6 0.1 0.46 9.8 0.0 2.2 3 0 0 3 3 3 0 AAA-like domain NB-ARC PF00931.17 KOO27175.1 - 0.13 11.1 0.0 0.63 8.8 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain UCH PF00443.24 KOO27177.1 - 3.4e-59 200.1 0.7 6e-59 199.3 0.5 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.3 KOO27177.1 - 1.3e-48 165.4 0.0 2.9e-48 164.3 0.0 1.6 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.1 KOO27177.1 - 1.4e-47 161.9 0.2 1.2e-36 126.1 0.0 3.0 3 0 0 3 3 3 2 Ubiquitin-specific protease C-terminal UCH_1 PF13423.1 KOO27177.1 - 3.1e-31 108.9 0.0 4.9e-31 108.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.21 KOO27177.1 - 2.5e-14 53.5 0.1 1.2e-13 51.3 0.0 2.3 2 0 0 2 2 2 1 MATH domain Ubiquitin_2 PF14560.1 KOO27177.1 - 0.0002 21.5 0.0 0.00087 19.4 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin-like domain ubiquitin PF00240.18 KOO27177.1 - 0.00085 18.6 0.0 0.015 14.6 0.0 3.0 2 0 0 2 2 2 1 Ubiquitin family PQ-loop PF04193.9 KOO27178.1 - 0.00071 19.0 0.3 0.00071 19.0 0.2 3.5 3 1 1 4 4 4 2 PQ loop repeat GHMP_kinases_N PF00288.21 KOO27178.1 - 0.45 10.6 0.1 0.45 10.6 0.1 2.8 3 0 0 3 3 3 0 GHMP kinases N terminal domain Baculo_PEP_C PF04513.7 KOO27179.1 - 0.85 9.4 9.0 0.28 10.9 0.5 2.9 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Glyco_transf_8 PF01501.15 KOO27180.1 - 0.04 13.2 0.0 0.051 12.8 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 8 PgaD PF13994.1 KOO27181.1 - 0.15 11.5 12.5 0.39 10.2 0.4 2.2 1 1 1 2 2 2 0 PgaD-like protein LRR_4 PF12799.2 KOO27183.1 - 7e-14 51.0 16.9 9.2e-08 31.5 3.8 3.4 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.1 KOO27183.1 - 5.8e-13 48.7 9.4 5.9e-11 42.2 1.7 2.0 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.1 KOO27183.1 - 8.6e-10 38.2 15.8 5.7e-07 29.1 6.5 3.4 3 0 0 3 3 3 2 Leucine rich repeat LRR_7 PF13504.1 KOO27183.1 - 0.0005 19.8 9.8 1.1 9.7 0.1 5.1 4 0 0 4 4 4 2 Leucine rich repeat LRR_6 PF13516.1 KOO27183.1 - 0.009 15.9 13.4 0.12 12.5 0.4 4.4 2 1 2 4 4 4 2 Leucine Rich repeat LRR_1 PF00560.28 KOO27183.1 - 0.032 14.2 17.6 0.6 10.3 0.2 5.8 6 0 0 6 6 6 0 Leucine Rich Repeat HTH_37 PF13744.1 KOO27184.1 - 0.0037 17.0 0.1 0.0073 16.0 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain DUF3606 PF12244.3 KOO27184.1 - 0.59 9.7 4.3 11 5.7 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3606) DUF768 PF05589.6 KOO27184.1 - 1.7 8.6 8.0 0.15 11.9 2.0 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF768) Bac_DNA_binding PF00216.16 KOO27184.1 - 1.9 8.5 5.6 3.7 7.6 0.1 2.7 2 1 1 3 3 3 0 Bacterial DNA-binding protein Pkinase_Tyr PF07714.12 KOO27185.1 - 8.9e-37 126.5 0.0 1.1e-36 126.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 KOO27185.1 - 1.7e-36 125.6 0.0 2.5e-36 125.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain PP2C PF00481.16 KOO27185.1 - 2.6e-30 105.6 0.0 3.8e-30 105.1 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOO27185.1 - 9.8e-06 25.4 0.9 0.00015 21.4 0.7 2.2 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 KOO27185.1 - 0.00027 20.3 1.0 0.0021 17.5 0.7 2.1 1 1 0 1 1 1 1 Protein phosphatase 2C FAD_binding_3 PF01494.14 KOO27186.1 - 0.01 14.9 0.1 0.05 12.6 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain DJ-1_PfpI PF01965.19 KOO27186.1 - 0.06 12.8 0.1 4.8 6.6 0.0 2.7 2 0 0 2 2 2 0 DJ-1/PfpI family NAD_binding_8 PF13450.1 KOO27186.1 - 0.06 13.3 0.1 0.39 10.7 0.1 2.5 1 1 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Arm PF00514.18 KOO27187.1 - 5.4e-23 79.9 0.5 3.1e-09 36.3 0.2 4.7 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 KOO27187.1 - 0.00031 19.9 0.0 0.34 9.9 0.0 2.1 1 1 1 2 2 2 2 Armadillo-like HEAT_2 PF13646.1 KOO27187.1 - 0.00037 20.7 1.7 0.00091 19.4 1.2 1.8 1 1 0 1 1 1 1 HEAT repeats HEAT PF02985.17 KOO27187.1 - 0.00089 19.1 1.1 0.35 11.0 0.0 3.9 5 0 0 5 5 5 1 HEAT repeat Atx10homo_assoc PF09759.4 KOO27187.1 - 0.0029 17.3 0.0 2.1 8.1 0.0 3.0 2 1 1 3 3 3 2 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.1 KOO27187.1 - 0.19 12.2 3.2 1.1 9.8 0.7 3.1 2 1 2 4 4 4 0 HEAT-like repeat Arm PF00514.18 KOO27188.1 - 1.1e-28 98.0 9.2 1.7e-08 33.9 0.0 5.3 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO27188.1 - 3.9e-05 23.8 11.3 0.015 15.5 0.1 3.3 1 1 3 4 4 4 3 HEAT repeats V-ATPase_H_N PF03224.9 KOO27188.1 - 0.087 11.9 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 V-ATPase subunit H HEAT_EZ PF13513.1 KOO27188.1 - 0.15 12.5 8.6 81 3.8 0.0 4.6 2 2 2 4 4 4 0 HEAT-like repeat AF1Q PF15017.1 KOO27189.1 - 5.4e-05 23.0 2.3 0.2 11.6 0.0 2.2 1 1 1 2 2 2 2 Drug resistance and apoptosis regulator cobW PF02492.14 KOO27190.1 - 1.7e-52 177.4 4.1 2.3e-52 177.0 2.8 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 KOO27190.1 - 1.7e-18 66.1 0.0 3e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain GTP_EFTU PF00009.22 KOO27190.1 - 0.00016 21.1 4.0 0.00065 19.1 2.8 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Arch_ATPase PF01637.13 KOO27190.1 - 0.0015 18.2 0.2 0.0045 16.7 0.0 1.8 2 0 0 2 2 2 1 Archaeal ATPase MMR_HSR1 PF01926.18 KOO27190.1 - 0.0033 17.3 0.5 0.02 14.8 0.2 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase MobB PF03205.9 KOO27190.1 - 0.0035 17.0 0.6 0.012 15.3 0.4 2.0 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_23 PF13476.1 KOO27190.1 - 0.004 17.4 4.7 0.11 12.7 3.3 2.2 1 1 0 1 1 1 1 AAA domain Arf PF00025.16 KOO27190.1 - 0.0049 16.1 2.8 0.64 9.2 0.5 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family DUF258 PF03193.11 KOO27190.1 - 0.012 14.8 0.0 0.026 13.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_14 PF13173.1 KOO27190.1 - 0.015 15.2 0.0 0.035 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain ArgK PF03308.11 KOO27190.1 - 0.021 13.6 1.9 0.033 12.9 0.2 2.1 2 1 0 2 2 2 0 ArgK protein Viral_helicase1 PF01443.13 KOO27190.1 - 0.033 13.7 0.1 0.087 12.3 0.0 1.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.1 KOO27190.1 - 0.04 13.6 0.3 0.12 12.1 0.2 1.8 1 0 0 1 1 1 0 Part of AAA domain NEL PF14496.1 KOO27190.1 - 0.052 12.8 0.7 0.088 12.0 0.5 1.3 1 0 0 1 1 1 0 C-terminal novel E3 ligase, LRR-interacting AAA_22 PF13401.1 KOO27190.1 - 0.056 13.5 0.2 0.13 12.4 0.1 1.8 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.5 KOO27190.1 - 0.057 12.6 0.1 0.12 11.5 0.1 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.1 KOO27190.1 - 0.073 12.6 0.1 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 KOO27190.1 - 0.074 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.1 KOO27190.1 - 0.085 12.8 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain SRP54 PF00448.17 KOO27190.1 - 0.089 12.2 1.5 0.34 10.3 0.9 2.0 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain ABC_tran PF00005.22 KOO27190.1 - 0.089 13.0 0.5 0.18 12.0 0.3 1.7 1 1 0 1 1 1 0 ABC transporter RE_NgoFVII PF09565.5 KOO27190.1 - 0.12 11.2 0.6 12 4.7 0.0 2.2 2 0 0 2 2 2 0 NgoFVII restriction endonuclease Septin PF00735.13 KOO27190.1 - 0.12 11.3 1.0 4.1 6.3 0.1 2.3 2 0 0 2 2 2 0 Septin FAD_binding_1 PF00667.15 KOO27191.1 - 1.4e-37 129.3 0.0 1.8e-37 128.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.16 KOO27191.1 - 1.3e-17 64.3 0.0 2.1e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain HTH_24 PF13412.1 KOO27191.1 - 0.058 12.7 0.0 12 5.3 0.0 2.6 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding NAD_binding_6 PF08030.7 KOO27191.1 - 0.12 12.2 0.0 0.27 11.1 0.0 1.5 1 1 0 1 1 1 0 Ferric reductase NAD binding domain TMF_DNA_bd PF12329.3 KOO27192.1 - 0.13 12.0 8.6 1.1 9.1 0.2 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Atg14 PF10186.4 KOO27192.1 - 0.17 10.7 12.4 0.24 10.3 8.6 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 ADIP PF11559.3 KOO27192.1 - 0.29 11.0 16.0 0.26 11.1 4.5 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF1517 PF07466.6 KOO27192.1 - 0.77 8.6 7.8 1.1 8.1 5.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1517) Pox_A_type_inc PF04508.7 KOO27192.1 - 0.79 9.6 0.1 0.79 9.6 0.1 3.3 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat DUF4140 PF13600.1 KOO27192.1 - 1.7 9.1 9.3 3.7 8.0 6.3 1.6 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Bap31 PF05529.7 KOO27192.1 - 1.9 7.9 7.8 5.7 6.3 5.4 1.8 1 1 0 1 1 1 0 B-cell receptor-associated protein 31-like DUF3571 PF12095.3 KOO27192.1 - 1.9 8.7 5.5 0.61 10.3 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3571) Fib_alpha PF08702.5 KOO27192.1 - 2.9 7.9 10.3 2.8 8.0 1.2 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Mnd1 PF03962.10 KOO27192.1 - 3.7 7.1 8.8 4.8 6.7 6.1 1.2 1 0 0 1 1 1 0 Mnd1 family TPR_12 PF13424.1 KOO27193.1 - 2.5e-92 302.8 32.9 2.5e-17 62.5 0.1 5.5 1 1 6 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.1 KOO27193.1 - 6.4e-76 248.3 36.4 1.5e-12 46.9 0.3 8.1 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_16 PF13432.1 KOO27193.1 - 2.8e-16 59.6 39.0 7.1e-06 26.5 2.5 4.7 3 1 0 5 5 4 4 Tetratricopeptide repeat TPR_4 PF07721.9 KOO27193.1 - 3.4e-16 57.9 48.0 0.02 15.2 1.1 8.1 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_1 PF00515.23 KOO27193.1 - 1.2e-15 56.3 1.3 0.98 9.1 0.0 7.2 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.12 KOO27193.1 - 2.3e-15 55.1 5.1 1 9.4 0.1 7.2 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO27193.1 - 1.2e-13 49.7 16.5 0.28 11.0 0.0 7.6 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.1 KOO27193.1 - 5.1e-13 48.3 43.9 0.025 15.2 0.5 7.4 3 2 4 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.1 KOO27193.1 - 4.6e-10 38.9 0.6 5.3 7.4 0.0 7.1 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOO27193.1 - 2.3e-09 36.7 7.8 0.089 12.4 0.2 5.5 2 2 3 5 5 5 4 TPR repeat TPR_19 PF14559.1 KOO27193.1 - 3.1e-08 33.8 26.8 0.012 15.8 2.1 4.9 4 1 0 4 4 4 4 Tetratricopeptide repeat FliG_M PF14841.1 KOO27193.1 - 6.7e-05 22.8 0.0 12 6.0 0.0 5.4 5 2 2 7 7 7 0 FliG middle domain UvsW PF11637.3 KOO27193.1 - 0.00037 20.1 0.5 2.4 7.9 0.0 5.0 6 0 0 6 6 6 1 ATP-dependant DNA helicase UvsW HisKA_3 PF07730.8 KOO27193.1 - 0.0016 18.7 14.6 4.4 7.7 0.1 6.8 5 3 0 6 6 6 1 Histidine kinase TPR_3 PF07720.7 KOO27193.1 - 0.0081 15.9 0.0 3.8 7.4 0.0 3.2 4 0 0 4 4 4 1 Tetratricopeptide repeat SSI PF00720.12 KOO27193.1 - 0.0082 16.0 4.8 10 6.1 0.0 4.7 1 1 6 7 7 7 0 Subtilisin inhibitor-like DUF3426 PF11906.3 KOO27193.1 - 0.1 12.2 2.3 7.5 6.2 0.0 4.0 3 2 2 5 5 5 0 Protein of unknown function (DUF3426) TPR_9 PF13371.1 KOO27193.1 - 0.28 11.0 25.5 5.8 6.8 0.0 6.6 1 1 6 7 7 7 0 Tetratricopeptide repeat TFIIA_gamma_N PF02268.11 KOO27193.1 - 9.1 5.9 16.1 50 3.5 0.1 5.6 6 0 0 6 6 6 0 Transcription initiation factor IIA, gamma subunit, helical domain Arm PF00514.18 KOO27194.1 - 7.9e-57 187.2 48.5 5.6e-06 25.9 0.1 15.5 15 1 0 15 15 15 14 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO27194.1 - 3.9e-10 39.8 51.2 0.0073 16.5 0.2 7.8 1 1 6 8 8 8 7 HEAT repeats Arm_2 PF04826.8 KOO27194.1 - 1.5e-06 27.5 1.8 0.56 9.2 0.0 5.5 2 2 3 6 6 6 1 Armadillo-like Atx10homo_assoc PF09759.4 KOO27194.1 - 1.9e-05 24.3 0.8 0.022 14.4 0.0 4.6 4 2 2 6 6 6 1 Spinocerebellar ataxia type 10 protein domain Adaptin_N PF01602.15 KOO27194.1 - 3e-05 22.5 1.1 0.05 11.9 0.0 3.9 2 2 2 4 4 4 2 Adaptin N terminal region RICTOR_N PF14664.1 KOO27194.1 - 0.0039 15.8 0.1 4.8 5.6 0.0 3.4 3 1 1 4 4 4 2 Rapamycin-insensitive companion of mTOR, N-term V-ATPase_H_N PF03224.9 KOO27194.1 - 0.0088 15.1 0.1 1.7 7.6 0.1 3.4 1 1 0 1 1 1 1 V-ATPase subunit H Neurochondrin PF05536.6 KOO27194.1 - 0.068 11.4 1.5 0.21 9.8 0.2 2.3 3 0 0 3 3 3 0 Neurochondrin CDC14 PF08045.6 KOO27194.1 - 0.076 12.1 0.0 0.77 8.8 0.0 2.3 2 0 0 2 2 2 0 Cell division control protein 14, SIN component Kinesin PF00225.18 KOO27195.1 - 1.5e-103 346.0 0.0 4.4e-103 344.5 0.0 1.7 2 0 0 2 2 2 1 Kinesin motor domain DnaJ PF00226.26 KOO27197.1 - 1.6e-21 75.7 0.3 3.5e-21 74.6 0.2 1.6 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.1 KOO27197.1 - 1.1e-12 47.7 0.0 2.2e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 X-domain of DnaJ-containing Ribosomal_L29e PF01779.12 KOO27197.1 - 0.14 12.0 0.2 0.43 10.4 0.2 1.8 1 0 0 1 1 1 0 Ribosomal L29e protein family ABC_membrane PF00664.18 KOO27198.1 - 2.1e-10 40.4 0.4 3.2e-10 39.9 0.2 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region Cytochrom_C PF00034.16 KOO27199.1 - 8.9e-12 45.6 0.4 1.4e-11 45.0 0.3 1.3 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.1 KOO27199.1 - 1.3e-08 34.8 5.2 1.3e-07 31.6 3.6 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.1 KOO27199.1 - 0.0071 15.7 1.3 0.076 12.4 0.4 2.1 2 0 0 2 2 2 1 Cytochrome c-550 domain zf-FCS PF06467.9 KOO27199.1 - 0.048 13.3 0.3 0.11 12.1 0.2 1.7 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif Cytochrom_C1 PF02167.10 KOO27199.1 - 0.2 11.3 1.6 0.33 10.5 0.6 1.9 1 1 1 2 2 2 0 Cytochrome C1 family Ribosomal_L7Ae PF01248.21 KOO27200.1 - 6.1e-24 83.3 1.3 8.7e-24 82.8 0.9 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 KOO27200.1 - 0.00024 20.9 0.0 0.00028 20.7 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 EIF_2_alpha PF07541.7 KOO27201.1 - 1.5e-32 111.7 0.0 5.7e-32 109.8 0.0 1.9 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.18 KOO27201.1 - 1.9e-14 53.5 0.3 3.6e-14 52.6 0.2 1.4 1 0 0 1 1 1 1 S1 RNA binding domain EXOSC1 PF10447.4 KOO27201.1 - 0.0088 15.9 0.2 0.027 14.4 0.1 1.9 1 1 0 1 1 1 1 Exosome component EXOSC1/CSL4 CENP-B_dimeris PF09026.5 KOO27201.1 - 0.01 16.0 1.2 0.01 16.0 0.8 2.1 2 0 0 2 2 2 0 Centromere protein B dimerisation domain zf-CCCH PF00642.19 KOO27202.1 - 2.1e-08 33.6 2.1 4.6e-08 32.5 1.4 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-RING_5 PF14634.1 KOO27202.1 - 1e-06 28.3 11.0 1.6e-06 27.6 7.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 KOO27202.1 - 8e-06 25.5 11.2 1.3e-05 24.9 7.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 KOO27202.1 - 8.4e-06 25.3 9.2 1.4e-05 24.6 6.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO27202.1 - 1.5e-05 24.9 11.8 2.7e-05 24.1 8.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO27202.1 - 0.0031 17.1 12.2 0.0059 16.2 8.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 KOO27202.1 - 0.0059 16.6 2.3 0.011 15.7 1.6 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_UBOX PF13445.1 KOO27202.1 - 0.11 12.2 7.0 0.24 11.1 4.9 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.1 KOO27202.1 - 0.14 12.0 7.3 0.54 10.1 5.2 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-P11 PF03854.9 KOO27202.1 - 0.51 9.8 7.1 1 8.8 4.9 1.4 1 0 0 1 1 1 0 P-11 zinc finger ARL2_Bind_BART PF11527.3 KOO27203.1 - 5.3e-13 48.8 0.0 4.2e-06 26.5 0.0 2.6 2 1 0 2 2 2 2 The ARF-like 2 binding protein BART Aa_trans PF01490.13 KOO27204.1 - 2.6e-19 68.9 1.9 3.3e-19 68.6 1.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Laminin_G_3 PF13385.1 KOO27205.1 - 7.6e-05 22.9 0.0 0.00013 22.1 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily PPI_Ypi1 PF07491.6 KOO27206.1 - 0.19 11.3 0.7 0.39 10.3 0.5 1.5 1 0 0 1 1 1 0 Protein phosphatase inhibitor ABC_tran PF00005.22 KOO27207.1 - 1.1e-25 90.5 0.0 1.6e-25 89.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 KOO27207.1 - 8.5e-07 28.6 0.7 1.2e-06 28.1 0.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.14 KOO27207.1 - 3.4e-06 26.4 0.1 0.00062 19.0 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 KOO27207.1 - 0.0014 18.6 0.0 0.33 10.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 KOO27207.1 - 0.0062 16.0 0.0 0.016 14.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.18 KOO27207.1 - 0.0078 16.1 0.0 0.035 14.0 0.1 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_30 PF13604.1 KOO27207.1 - 0.0093 15.5 0.0 0.037 13.6 0.0 1.9 2 1 0 2 2 2 1 AAA domain DUF87 PF01935.12 KOO27207.1 - 0.02 14.7 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF87 AAA_22 PF13401.1 KOO27207.1 - 0.03 14.4 0.1 12 6.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 KOO27207.1 - 0.065 12.6 0.3 0.63 9.4 0.1 2.2 1 1 0 2 2 2 0 AAA-like domain AAA_16 PF13191.1 KOO27207.1 - 0.076 12.9 1.6 0.64 9.9 1.1 2.3 1 1 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.1 KOO27207.1 - 0.1 11.9 0.2 0.23 10.8 0.2 1.8 1 1 0 1 1 1 0 AAA domain SbcCD_C PF13558.1 KOO27207.1 - 0.11 12.3 0.1 0.39 10.6 0.1 2.0 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit TLD PF07534.11 KOO27209.1 - 3.3e-09 36.8 0.0 4.3e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 TLD TPR_17 PF13431.1 KOO27210.1 - 2.8e-05 23.9 2.1 0.55 10.5 0.0 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO27210.1 - 0.0059 16.1 2.5 0.31 10.7 0.3 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO27210.1 - 0.014 15.2 1.4 0.014 15.2 1.0 5.7 6 2 1 7 7 7 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOO27210.1 - 0.057 13.2 3.0 0.13 12.0 0.1 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO27210.1 - 0.098 12.6 0.3 0.098 12.6 0.2 3.8 4 1 0 4 4 4 0 Tetratricopeptide repeat APG6 PF04111.7 KOO27211.1 - 0.0017 17.4 6.2 0.0027 16.8 4.3 1.4 1 0 0 1 1 1 1 Autophagy protein Apg6 Mnd1 PF03962.10 KOO27211.1 - 0.017 14.7 8.5 0.026 14.1 5.9 1.2 1 0 0 1 1 1 0 Mnd1 family AAA_11 PF13086.1 KOO27211.1 - 0.02 14.4 1.2 0.026 14.0 0.8 1.2 1 0 0 1 1 1 0 AAA domain CCDC-167 PF15188.1 KOO27211.1 - 0.084 12.8 11.0 0.15 11.9 7.6 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 Seadorna_VP6 PF07407.6 KOO27211.1 - 0.11 11.2 4.2 0.15 10.7 2.9 1.2 1 0 0 1 1 1 0 Seadornavirus VP6 protein PV-1 PF06637.6 KOO27211.1 - 0.27 9.7 7.1 0.43 9.0 4.9 1.3 1 0 0 1 1 1 0 PV-1 protein (PLVAP) ERM PF00769.14 KOO27211.1 - 0.44 10.0 14.5 0.64 9.5 10.0 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DivIC PF04977.10 KOO27211.1 - 0.44 10.0 12.0 7.5 6.1 7.7 2.2 2 0 0 2 2 2 0 Septum formation initiator DUF4047 PF13256.1 KOO27211.1 - 0.5 10.3 4.5 0.71 9.8 3.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) DUF2681 PF10883.3 KOO27211.1 - 0.51 10.5 5.1 1.2 9.4 3.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) IncA PF04156.9 KOO27211.1 - 0.58 9.7 12.5 0.94 9.0 8.6 1.6 1 1 0 1 1 1 0 IncA protein Peptidase_S49_N PF08496.5 KOO27211.1 - 4.6 7.0 6.9 7.2 6.3 4.8 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF4337 PF14235.1 KOO27211.1 - 5.9 6.7 12.0 11 5.8 7.9 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) V_ATPase_I PF01496.14 KOO27211.1 - 8.6 4.0 9.0 12 3.6 6.2 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family ABM PF03992.11 KOO27212.1 - 4.2e-08 33.1 0.0 6.4e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase ATP-synt_J PF04911.7 KOO27212.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 ATP synthase j chain EF-hand_6 PF13405.1 KOO27213.1 - 1.7e-14 52.3 0.3 2.8e-05 23.6 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.27 KOO27213.1 - 1.9e-13 48.6 0.9 6.3e-05 21.9 0.0 3.9 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.1 KOO27213.1 - 1.1e-12 47.8 0.1 3.4e-05 23.9 0.0 2.4 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO27213.1 - 2e-08 33.7 4.6 0.0042 16.6 0.0 4.8 3 2 2 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO27213.1 - 5.6e-05 22.3 0.1 0.7 9.3 0.0 3.4 4 0 0 4 4 4 2 EF hand EF-hand_9 PF14658.1 KOO27213.1 - 0.00024 20.9 0.0 0.23 11.3 0.0 2.4 2 1 0 2 2 2 2 EF-hand domain Glutaredoxin PF00462.19 KOO27214.1 - 2.5e-09 36.9 0.0 4.2e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.1 KOO27214.1 - 0.00038 20.6 0.0 0.0011 19.1 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 KOO27214.1 - 0.079 12.9 0.1 0.19 11.7 0.0 1.6 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain EF-hand_7 PF13499.1 KOO27215.1 - 2.8e-16 59.3 4.9 3.2e-07 30.3 0.1 2.8 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO27215.1 - 2e-15 54.8 11.6 1.4e-06 27.2 0.3 4.8 4 1 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 KOO27215.1 - 2.6e-15 54.8 7.9 0.00034 20.2 0.0 4.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.1 KOO27215.1 - 1.8e-11 42.8 6.3 0.00015 20.9 0.7 4.2 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO27215.1 - 8.6e-11 41.2 9.4 1.7e-08 33.9 0.3 3.9 2 2 2 4 4 4 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO27215.1 - 3.1e-05 23.9 0.0 0.096 12.7 0.0 2.4 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO27215.1 - 4.6e-05 23.1 0.3 0.0028 17.3 0.0 2.7 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.1 KOO27216.1 - 1.8e-28 96.5 3.1 0.00058 19.0 0.1 6.7 6 0 0 6 6 6 6 EF hand EF-hand_1 PF00036.27 KOO27216.1 - 1.3e-25 86.6 0.0 0.0005 19.1 0.1 6.6 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.1 KOO27216.1 - 3.6e-21 73.0 0.3 0.019 14.7 0.1 6.8 6 0 0 6 6 6 6 EF-hand domain EF-hand_7 PF13499.1 KOO27216.1 - 2e-18 66.2 0.0 6.6e-05 22.9 0.0 4.3 2 1 3 5 5 5 5 EF-hand domain pair EF-hand_8 PF13833.1 KOO27216.1 - 1.7e-11 43.5 3.8 0.14 11.8 0.7 6.3 5 1 1 6 6 6 5 EF-hand domain pair GPS PF01825.16 KOO27216.1 - 1.1e-06 28.5 0.1 1.9e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Latrophilin/CL-1-like GPS domain PDZ PF00595.19 KOO27216.1 - 0.0064 16.6 0.1 0.019 15.1 0.0 1.8 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO27216.1 - 0.071 13.0 0.0 0.31 10.9 0.0 2.0 2 0 0 2 2 2 0 PDZ domain DUF2807 PF10988.3 KOO27216.1 - 1.6 8.1 6.8 0.87 9.0 2.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2807) Excalibur PF05901.6 KOO27216.1 - 5.5 7.4 12.8 48 4.4 0.6 5.1 4 1 0 4 4 4 0 Excalibur calcium-binding domain Aminotran_5 PF00266.14 KOO27217.1 - 1.3e-26 93.2 0.0 1.4e-22 79.9 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V Pkinase PF00069.20 KOO27219.1 - 5e-46 156.9 0.0 1.4e-33 116.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27219.1 - 8.6e-45 152.8 0.0 1.2e-44 152.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PP2C PF00481.16 KOO27219.1 - 1e-13 51.2 0.0 1.6e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C Kdo PF06293.9 KOO27219.1 - 0.00013 21.1 0.0 0.00025 20.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO27219.1 - 0.0003 20.5 0.3 0.0003 20.5 0.2 2.9 3 1 0 3 3 3 1 Phosphotransferase enzyme family SpoIIE PF07228.7 KOO27219.1 - 0.0049 16.5 0.3 0.55 9.9 0.1 2.8 3 0 0 3 3 3 1 Stage II sporulation protein E (SpoIIE) Kinase-like PF14531.1 KOO27219.1 - 0.025 13.5 0.0 0.05 12.5 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Pkinase PF00069.20 KOO27220.1 - 1.3e-37 129.3 0.0 1.5e-37 129.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27220.1 - 1.1e-13 50.9 0.0 2e-13 50.0 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO27220.1 - 0.0024 17.6 0.0 0.0065 16.2 0.0 1.7 2 1 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 KOO27220.1 - 0.064 12.0 0.4 0.1 11.3 0.3 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase PF00069.20 KOO27221.1 - 2.6e-41 141.4 0.0 3e-41 141.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27221.1 - 2.7e-41 141.3 0.0 3.1e-41 141.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO27221.1 - 0.34 10.6 3.8 0.37 10.5 0.6 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family MFS_1 PF07690.11 KOO27222.1 - 1.5e-11 43.6 32.6 1.5e-11 43.6 22.6 2.5 1 1 1 2 2 2 1 Major Facilitator Superfamily Ank PF00023.25 KOO27223.1 - 5.9e-28 95.2 15.8 2.1e-07 30.3 0.0 7.4 7 0 0 7 7 7 5 Ankyrin repeat Ank_2 PF12796.2 KOO27223.1 - 3e-27 94.7 5.3 4.9e-13 49.2 0.1 4.4 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO27223.1 - 3.2e-23 79.4 9.5 6e-05 22.9 0.0 7.6 7 0 0 7 7 7 5 Ankyrin repeat Ank_4 PF13637.1 KOO27223.1 - 9.2e-21 73.8 7.6 2.4e-09 37.4 0.0 4.6 5 0 0 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO27223.1 - 8.9e-20 70.2 14.6 8.1e-07 29.0 0.3 7.1 3 1 4 7 7 7 5 Ankyrin repeats (many copies) Ion_trans PF00520.26 KOO27223.1 - 1e-14 54.2 6.3 3.3e-14 52.5 4.4 1.9 1 1 0 1 1 1 1 Ion transport protein Hemagglutinin PF00509.13 KOO27223.1 - 0.29 9.2 0.3 0.43 8.6 0.2 1.1 1 0 0 1 1 1 0 Haemagglutinin ENT PF03735.9 KOO27224.1 - 0.02 14.6 0.2 0.085 12.5 0.1 2.1 1 0 0 1 1 1 0 ENT domain Dpy-30 PF05186.8 KOO27226.1 - 0.049 13.1 0.1 0.093 12.2 0.1 1.4 1 0 0 1 1 1 0 Dpy-30 motif MutS_V PF00488.16 KOO27227.1 - 2.9e-80 269.0 0.0 5.9e-80 268.0 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 KOO27227.1 - 1.1e-39 136.3 1.0 2.1e-39 135.4 0.7 1.5 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.15 KOO27227.1 - 1.4e-34 118.5 0.0 3e-34 117.4 0.0 1.6 1 0 0 1 1 1 1 MutS domain I MutS_IV PF05190.13 KOO27227.1 - 1.4e-08 34.7 0.0 3.4e-08 33.5 0.0 1.7 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.12 KOO27227.1 - 3.4e-08 33.6 0.0 7e-07 29.3 0.0 2.8 3 0 0 3 3 3 1 MutS domain II AAA_29 PF13555.1 KOO27227.1 - 0.084 12.4 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Abhydrolase_5 PF12695.2 KOO27231.1 - 8.3e-05 22.3 1.3 0.00044 20.0 0.2 2.7 2 2 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 KOO27231.1 - 0.008 15.6 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.16 KOO27231.1 - 0.056 12.6 0.1 8.2 5.5 0.0 2.3 1 1 1 2 2 2 0 Prolyl oligopeptidase family Prenyltrans PF00432.16 KOO27232.1 - 5.2e-28 96.2 22.1 3.3e-08 32.9 0.2 6.6 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 KOO27232.1 - 7.3e-18 65.0 5.3 1.4e-11 44.8 0.1 4.4 1 1 4 5 5 5 4 Prenyltransferase-like Prenyltrans_1 PF13243.1 KOO27232.1 - 0.0089 16.0 0.0 0.13 12.3 0.0 2.3 1 1 1 2 2 2 2 Prenyltransferase-like DnaJ PF00226.26 KOO27233.1 - 2.6e-23 81.5 0.3 4.2e-23 80.8 0.2 1.3 1 0 0 1 1 1 1 DnaJ domain Tmemb_185A PF10269.4 KOO27233.1 - 3e-16 59.7 18.0 4e-09 36.4 2.1 2.3 1 1 2 3 3 3 3 Transmembrane Fragile-X-F protein TRP PF06011.7 KOO27233.1 - 7.1 5.0 6.0 0.57 8.6 0.9 1.5 2 0 0 2 2 2 0 Transient receptor potential (TRP) ion channel Bestrophin PF01062.16 KOO27235.1 - 4.5e-35 121.0 0.3 5.9e-35 120.6 0.2 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel EF-hand_5 PF13202.1 KOO27235.1 - 0.001 18.2 0.2 0.0023 17.1 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KOO27235.1 - 0.011 15.0 0.1 0.026 13.8 0.0 1.6 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.1 KOO27235.1 - 0.037 13.8 0.0 0.095 12.6 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain cNMP_binding PF00027.24 KOO27236.1 - 0.0006 19.5 0.0 0.0019 17.9 0.0 2.0 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Popeye PF04831.8 KOO27236.1 - 0.018 14.7 0.0 0.028 14.1 0.0 1.3 1 0 0 1 1 1 0 Popeye protein conserved region Aldo_ket_red PF00248.16 KOO27238.1 - 2e-68 230.2 0.0 2.3e-68 230.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Corona_RPol_N PF06478.8 KOO27238.1 - 0.028 13.1 0.0 0.042 12.5 0.0 1.2 1 0 0 1 1 1 0 Coronavirus RPol N-terminus PHBC_N PF12551.3 KOO27238.1 - 0.11 11.9 0.0 0.34 10.4 0.0 1.9 1 0 0 1 1 1 0 Poly-beta-hydroxybutyrate polymerase N terminal Iso_dh PF00180.15 KOO27239.1 - 2.1e-21 76.2 0.0 4.2e-21 75.2 0.0 1.5 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase EF-hand_1 PF00036.27 KOO27239.1 - 8.7e-07 27.8 0.2 2.2e-06 26.5 0.1 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO27239.1 - 2.8e-06 26.7 0.1 1.1e-05 24.9 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.1 KOO27239.1 - 4.3e-05 23.5 0.0 0.00012 22.1 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO27239.1 - 4.6e-05 22.5 0.4 0.0001 21.4 0.3 1.6 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 KOO27239.1 - 0.03 13.9 0.1 0.066 12.8 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair Abhydrolase_3 PF07859.8 KOO27240.1 - 0.00025 20.7 0.0 0.00034 20.2 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 KOO27240.1 - 0.0041 17.0 4.8 0.018 14.9 3.3 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Myb_DNA-binding PF00249.26 KOO27241.1 - 1.1e-19 70.1 7.2 4.8e-11 42.5 0.7 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO27241.1 - 1.4e-18 66.7 10.5 9e-14 51.3 3.5 3.9 3 2 1 4 4 4 2 Myb-like DNA-binding domain Myb_Cef PF11831.3 KOO27241.1 - 5.2e-15 55.2 0.0 5.2e-15 55.2 0.0 3.4 3 0 0 3 3 3 1 pre-mRNA splicing factor component MORN PF02493.15 KOO27242.1 - 7.7e-18 63.0 14.8 6.4e-06 25.5 1.4 3.6 3 0 0 3 3 3 3 MORN repeat SNF2_N PF00176.18 KOO27244.1 - 3.9e-09 35.7 0.4 0.00062 18.6 0.0 2.2 1 1 1 2 2 2 2 SNF2 family N-terminal domain Chromo PF00385.19 KOO27244.1 - 9.3e-09 34.8 1.0 2.4e-08 33.4 0.2 2.1 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain PHD PF00628.24 KOO27244.1 - 1.6e-07 30.8 0.9 1.6e-07 30.8 0.6 2.9 2 1 1 3 3 2 1 PHD-finger Agenet PF05641.7 KOO27244.1 - 1.8e-07 31.1 1.0 4.2e-06 26.8 0.0 3.4 3 0 0 3 3 3 1 Agenet domain C1_1 PF00130.17 KOO27244.1 - 4.3e-05 23.1 3.7 0.04 13.6 0.1 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_3 PF07649.7 KOO27244.1 - 0.00048 20.1 7.5 0.00048 20.1 5.2 2.2 2 0 0 2 2 2 1 C1-like domain zf-PHD-like PF15446.1 KOO27244.1 - 0.0077 15.5 0.6 0.025 13.8 0.4 1.9 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain FANCL_C PF11793.3 KOO27244.1 - 0.0094 15.8 0.3 0.022 14.7 0.2 1.5 1 0 0 1 1 1 1 FANCL C-terminal domain ZZ PF00569.12 KOO27244.1 - 0.013 14.9 1.7 0.041 13.4 1.2 1.8 1 0 0 1 1 1 0 Zinc finger, ZZ type zf-HC5HC2H PF13771.1 KOO27244.1 - 0.016 15.3 0.0 0.059 13.5 0.0 2.0 1 0 0 1 1 1 0 PHD-like zinc-binding domain IBR PF01485.16 KOO27244.1 - 0.026 14.3 0.6 0.026 14.3 0.4 2.6 2 1 0 2 2 2 0 IBR domain Prok-RING_1 PF14446.1 KOO27244.1 - 0.19 11.5 13.2 0.034 13.8 1.5 2.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 PALP PF00291.20 KOO27245.1 - 3.1e-56 190.8 0.0 3.9e-56 190.5 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme HAUS4 PF14735.1 KOO27247.1 - 0.18 11.0 3.8 0.23 10.7 2.6 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 DBINO PF13892.1 KOO27247.1 - 1.6 8.7 8.7 1.9 8.5 6.0 1.2 1 0 0 1 1 1 0 DNA-binding domain DUF3987 PF13148.1 KOO27247.1 - 5.2 5.5 9.7 6 5.3 6.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Radial_spoke_3 PF06098.6 KOO27247.1 - 8.5 5.2 11.4 9 5.2 7.9 1.2 1 0 0 1 1 1 0 Radial spoke protein 3 ADK PF00406.17 KOO27248.1 - 7.2e-25 87.6 0.0 1.3e-24 86.8 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase NUDIX PF00293.23 KOO27248.1 - 6.2e-05 22.6 0.3 0.0029 17.2 0.0 2.4 2 0 0 2 2 2 1 NUDIX domain AAA_17 PF13207.1 KOO27248.1 - 0.00077 20.2 0.0 0.0023 18.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain DUF411 PF04214.8 KOO27248.1 - 0.049 13.1 0.1 0.11 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF PDEase_I_N PF08499.7 KOO27249.1 - 0.12 12.2 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase N-terminal PfkB PF00294.19 KOO27250.1 - 2.2e-41 141.9 0.1 2.7e-41 141.6 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase DAGK_cat PF00781.19 KOO27250.1 - 0.0085 15.5 0.2 0.021 14.2 0.1 1.6 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain Metallophos_2 PF12850.2 KOO27251.1 - 2.9e-06 27.2 0.0 5e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 KOO27251.1 - 0.0058 16.0 0.9 0.14 11.4 0.6 2.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_10 PF13374.1 KOO27251.1 - 0.033 14.1 0.4 0.29 11.1 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Cupin_8 PF13621.1 KOO27252.1 - 1e-12 48.0 0.2 9.8e-12 44.8 0.1 2.1 1 1 1 2 2 2 1 Cupin-like domain Cupin_4 PF08007.7 KOO27252.1 - 0.0079 15.4 0.4 0.024 13.9 0.0 1.7 2 0 0 2 2 2 1 Cupin superfamily protein DUF1079 PF06435.6 KOO27252.1 - 7.2 6.6 9.4 46 4.0 0.3 3.3 3 0 0 3 3 3 0 Repeat of unknown function (DUF1079) Ion_trans PF00520.26 KOO27253.1 - 7.9e-170 560.6 47.6 5e-47 159.7 0.1 4.3 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 KOO27253.1 - 4.9e-06 25.2 4.1 4.9e-06 25.2 2.8 9.4 8 3 3 11 11 11 3 Polycystin cation channel RNA_GG_bind PF10258.4 KOO27253.1 - 0.49 10.1 0.3 1.1 8.9 0.2 1.5 1 0 0 1 1 1 0 PHAX RNA-binding domain Metallophos PF00149.23 KOO27254.1 - 6.6e-32 110.5 0.1 9.3e-32 110.0 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KOO27254.1 - 0.0059 16.4 0.0 0.0088 15.8 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Pheromone PF08015.6 KOO27254.1 - 4.7 8.1 0.0 4.7 8.1 0.0 3.5 3 1 0 3 3 3 0 Fungal mating-type pheromone Nuc_sug_transp PF04142.10 KOO27257.1 - 2.7e-62 210.0 3.8 4.2e-62 209.4 2.7 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.15 KOO27257.1 - 5e-07 29.7 2.3 5e-07 29.7 1.6 2.8 2 1 0 2 2 2 1 EamA-like transporter family TPT PF03151.11 KOO27257.1 - 8.6e-07 28.7 11.7 7e-05 22.5 1.1 2.9 2 1 0 3 3 3 2 Triose-phosphate Transporter family EmrE PF13536.1 KOO27257.1 - 0.00014 22.0 3.2 0.00014 22.0 2.2 3.2 2 1 1 3 3 3 1 Multidrug resistance efflux transporter UAA PF08449.6 KOO27257.1 - 0.00062 18.7 0.1 0.00062 18.7 0.1 1.5 2 0 0 2 2 2 1 UAA transporter family Multi_Drug_Res PF00893.14 KOO27257.1 - 0.8 10.2 14.6 1.3 9.5 0.2 3.8 3 2 0 3 3 3 0 Small Multidrug Resistance protein HlyIII PF03006.15 KOO27257.1 - 5.7 6.2 8.1 2.3 7.5 2.2 2.3 2 1 0 2 2 2 0 Haemolysin-III related HECT PF00632.20 KOO27258.1 - 0.00037 19.7 0.0 0.00047 19.4 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) TPR_9 PF13371.1 KOO27259.1 - 0.1 12.4 0.0 1.8 8.4 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Ank_2 PF12796.2 KOO27260.1 - 2.2e-73 242.6 24.7 1.1e-16 60.8 1.7 6.1 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO27260.1 - 4.3e-53 176.8 22.0 2.9e-08 33.9 0.2 9.7 5 3 5 10 10 10 9 Ankyrin repeats (many copies) Ank PF00023.25 KOO27260.1 - 4.4e-49 161.9 30.4 3.6e-06 26.5 0.0 11.8 12 0 0 12 12 12 10 Ankyrin repeat Ank_3 PF13606.1 KOO27260.1 - 1.9e-41 135.8 17.4 0.00044 20.2 0.0 12.5 13 0 0 13 13 13 9 Ankyrin repeat Ank_5 PF13857.1 KOO27260.1 - 4.9e-34 115.5 26.9 1.4e-06 28.2 0.6 8.8 4 2 5 10 10 10 8 Ankyrin repeats (many copies) TPR_11 PF13414.1 KOO27260.1 - 0.033 13.8 0.5 0.4 10.3 0.0 2.8 3 0 0 3 3 3 0 TPR repeat TPR_2 PF07719.12 KOO27260.1 - 0.34 10.9 2.4 6.4 6.9 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 KOO27260.1 - 9.2 7.0 16.1 11 6.8 2.4 4.6 4 1 0 4 4 4 0 Tetratricopeptide repeat tRNA-synt_1b PF00579.20 KOO27261.1 - 1.5e-18 66.9 0.0 5.6e-18 65.0 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) Big_3_2 PF12245.3 KOO27262.1 - 0.044 13.3 0.1 11 5.6 0.0 2.4 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) LRR_6 PF13516.1 KOO27263.1 - 3.2e-28 94.6 5.0 5.4e-05 22.8 0.0 8.5 9 0 0 9 9 9 5 Leucine Rich repeat Ank PF00023.25 KOO27263.1 - 1.1e-15 56.5 0.2 7e-09 35.0 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 KOO27263.1 - 1.1e-13 51.3 0.5 3.1e-13 49.8 0.1 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO27263.1 - 9.2e-12 44.8 0.4 1.3e-10 41.1 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO27263.1 - 5.5e-10 39.4 0.9 1.5e-07 31.7 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO27263.1 - 3.7e-08 32.8 0.1 0.0015 18.5 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat LRR_4 PF12799.2 KOO27263.1 - 0.0017 17.9 8.5 8.9 6.0 0.5 5.6 3 2 3 6 6 5 1 Leucine Rich repeats (2 copies) SpoU_sub_bind PF08032.7 KOO27263.1 - 0.0078 16.3 8.9 0.58 10.3 0.1 4.5 4 1 1 5 5 5 2 RNA 2'-O ribose methyltransferase substrate binding LRR_7 PF13504.1 KOO27263.1 - 0.051 13.7 4.6 1.2e+02 3.5 0.0 5.9 6 0 0 6 6 5 0 Leucine rich repeat EIF_2_alpha PF07541.7 KOO27263.1 - 0.27 10.9 1.2 3.2 7.5 0.1 2.9 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 2 alpha subunit Phage_integ_N PF09003.5 KOO27263.1 - 1.2 8.8 4.6 21 4.9 0.0 3.3 3 0 0 3 3 3 0 Bacteriophage lambda integrase, N-terminal domain SET PF00856.23 KOO27264.1 - 1.9e-20 73.8 1.7 4.9e-20 72.4 0.3 2.2 2 1 0 2 2 2 1 SET domain Y2_Tnp PF04986.8 KOO27264.1 - 0.0085 15.8 0.1 0.022 14.5 0.0 1.6 1 1 0 1 1 1 1 Putative transposase FKBP_C PF00254.23 KOO27266.1 - 1.2e-30 105.3 0.0 1.8e-30 104.8 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase UPF0184 PF03670.8 KOO27268.1 - 7.1 6.8 8.3 4.1 7.6 0.4 3.3 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0184) Beach PF02138.13 KOO27270.1 - 4.1e-106 354.3 0.0 5.6e-106 353.9 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.1 KOO27270.1 - 1.9e-10 40.5 0.0 1.2e-09 37.9 0.0 2.2 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH WD40 PF00400.27 KOO27270.1 - 1.9e-08 33.8 2.7 0.0016 18.2 0.1 4.3 5 0 0 5 5 5 2 WD domain, G-beta repeat Laminin_G_3 PF13385.1 KOO27270.1 - 0.00017 21.8 0.0 0.00036 20.8 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF1088 PF06469.6 KOO27270.1 - 0.00059 19.2 0.1 0.0011 18.3 0.1 1.4 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1088) WD40 PF00400.27 KOO27272.1 - 6.2e-14 51.2 8.4 1.2e-06 28.1 0.2 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat 2Fe-2S_thioredx PF01257.14 KOO27272.1 - 0.0047 16.5 2.3 0.017 14.7 1.6 1.9 1 1 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin TFIIIC_delta PF12657.2 KOO27272.1 - 0.0099 15.6 0.0 1.1 8.9 0.0 2.4 2 0 0 2 2 2 2 Transcription factor IIIC subunit delta N-term TPR_10 PF13374.1 KOO27273.1 - 3.7e-116 376.2 69.9 1.7e-12 46.8 0.5 15.9 14 2 1 15 15 15 13 Tetratricopeptide repeat TPR_12 PF13424.1 KOO27273.1 - 1.3e-100 329.4 45.7 1.9e-17 62.9 0.5 10.5 4 2 7 12 12 12 9 Tetratricopeptide repeat TPR_1 PF00515.23 KOO27273.1 - 4.6e-39 130.4 7.9 0.0033 16.9 0.0 11.3 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_4 PF07721.9 KOO27273.1 - 7.4e-33 109.5 13.2 0.011 16.0 0.0 12.4 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_2 PF07719.12 KOO27273.1 - 2.5e-29 98.7 18.1 0.03 14.2 0.0 11.7 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_16 PF13432.1 KOO27273.1 - 1.8e-28 98.5 29.3 3.1e-06 27.6 0.1 7.5 4 2 0 6 6 6 6 Tetratricopeptide repeat TPR_11 PF13414.1 KOO27273.1 - 6.2e-27 93.0 14.8 1.9e-05 24.2 0.0 8.1 5 3 2 8 8 8 7 TPR repeat TPR_7 PF13176.1 KOO27273.1 - 1.2e-20 71.6 27.0 0.18 11.6 0.2 11.7 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_17 PF13431.1 KOO27273.1 - 1e-19 69.0 1.5 0.57 10.5 0.0 10.8 11 0 0 11 11 11 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO27273.1 - 5.6e-17 60.1 9.5 0.15 11.9 0.0 10.1 11 0 0 11 11 10 4 Tetratricopeptide repeat TPR_14 PF13428.1 KOO27273.1 - 6.2e-15 54.3 43.6 0.36 11.6 0.0 12.4 11 1 1 12 12 11 5 Tetratricopeptide repeat TPR_19 PF14559.1 KOO27273.1 - 9.7e-14 51.4 33.5 0.0064 16.8 1.0 8.2 5 2 4 9 9 9 7 Tetratricopeptide repeat TPR_3 PF07720.7 KOO27273.1 - 2.2e-10 40.0 0.0 1.4 8.8 0.0 8.5 10 0 0 10 10 10 2 Tetratricopeptide repeat Apc3 PF12895.2 KOO27273.1 - 8.5e-09 35.4 0.0 0.46 10.6 0.0 5.3 2 1 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 Osmo_CC PF08946.5 KOO27273.1 - 1.1e-06 28.5 16.5 6.3 6.9 0.0 10.7 12 0 0 12 12 12 1 Osmosensory transporter coiled coil ApoLp-III PF07464.6 KOO27273.1 - 0.0018 18.3 11.4 7.9 6.4 0.0 6.2 4 2 4 8 8 8 0 Apolipophorin-III precursor (apoLp-III) TPR_6 PF13174.1 KOO27273.1 - 0.0084 16.5 7.0 1e+02 3.7 0.0 8.1 10 0 0 10 10 9 0 Tetratricopeptide repeat DUF3368 PF11848.3 KOO27273.1 - 0.29 10.7 23.1 39 3.9 0.1 9.0 10 0 0 10 10 10 0 Domain of unknown function (DUF3368) PPR_1 PF12854.2 KOO27273.1 - 0.51 9.8 16.4 1.1e+02 2.4 0.0 8.6 10 0 0 10 10 10 0 PPR repeat DUF3423 PF11903.3 KOO27274.1 - 0.0021 17.8 0.5 0.0078 15.9 0.3 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3423) Med11 PF10280.4 KOO27274.1 - 0.0032 17.5 5.5 0.083 12.9 2.5 2.6 2 1 0 2 2 2 1 Mediator complex protein DUF3708 PF12501.3 KOO27274.1 - 0.061 13.1 5.4 0.033 14.0 0.7 2.5 3 0 0 3 3 3 0 Phosphate ATP-binding cassette transporter KMP11 PF03037.11 KOO27274.1 - 0.095 13.2 0.1 0.095 13.2 0.1 2.4 2 1 1 3 3 3 0 Kinetoplastid membrane protein 11 TSC22 PF01166.13 KOO27274.1 - 0.29 11.1 13.5 0.71 9.8 0.5 4.4 4 0 0 4 4 4 0 TSC-22/dip/bun family MbeD_MobD PF04899.7 KOO27274.1 - 0.89 9.4 16.3 2.1 8.2 0.1 4.2 4 0 0 4 4 4 0 MbeD/MobD like Phasin PF05597.6 KOO27274.1 - 1.9 8.2 20.3 0.38 10.5 4.8 3.4 3 1 0 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Fib_alpha PF08702.5 KOO27274.1 - 2.9 8.0 12.7 1.8 8.6 1.7 3.0 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family IncA PF04156.9 KOO27274.1 - 5.8 6.4 34.5 10 5.6 0.0 3.7 3 1 0 3 3 3 0 IncA protein DUF972 PF06156.8 KOO27274.1 - 5.8 7.3 0.0 5.8 7.3 0.0 4.1 3 2 1 4 4 4 0 Protein of unknown function (DUF972) Tropomyosin_1 PF12718.2 KOO27274.1 - 7.4 6.4 40.2 0.15 11.8 10.5 4.8 3 2 2 5 5 5 0 Tropomyosin like EF-hand_1 PF00036.27 KOO27275.1 - 6.6e-12 43.8 0.6 1.7e-05 23.7 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO27275.1 - 2.2e-11 43.2 0.5 2.3e-08 33.5 0.0 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO27275.1 - 2.9e-11 42.2 0.3 0.00025 20.6 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO27275.1 - 4.1e-10 39.6 0.0 4.3e-05 23.5 0.0 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO27275.1 - 0.00016 20.8 12.5 0.00045 19.4 0.1 3.2 4 0 0 4 4 4 2 EF hand EF-hand_1 PF00036.27 KOO27276.1 - 2.4e-08 32.7 0.5 5.1e-07 28.5 0.0 2.7 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.1 KOO27276.1 - 5.3e-07 29.6 0.0 1.5e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO27276.1 - 1e-06 28.1 1.6 4e-06 26.2 0.0 2.6 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.1 KOO27276.1 - 6e-06 25.3 0.1 4e-05 22.7 0.0 2.3 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.1 KOO27276.1 - 0.00036 20.1 0.2 0.051 13.1 0.1 2.7 2 0 0 2 2 2 1 EF-hand domain pair DNA_ligase_A_N PF04675.9 KOO27276.1 - 0.11 12.2 0.4 0.42 10.3 0.0 2.0 2 1 0 2 2 2 0 DNA ligase N terminus Acyl-CoA_dh_N PF02771.11 KOO27276.1 - 0.15 12.6 0.6 0.57 10.7 0.1 2.1 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, N-terminal domain Exostosin PF03016.10 KOO27277.1 - 1.1e-41 142.8 0.8 1.1e-41 142.8 0.5 2.5 2 1 0 2 2 2 1 Exostosin family EGF_2 PF07974.8 KOO27277.1 - 2.4e-09 37.1 44.8 0.00035 20.6 5.4 4.6 4 0 0 4 4 4 3 EGF-like domain Laminin_EGF PF00053.19 KOO27277.1 - 0.0044 16.9 32.1 0.0085 16.0 4.3 3.6 2 1 1 3 3 3 2 Laminin EGF-like (Domains III and V) Sirohm_synth_C PF14823.1 KOO27277.1 - 0.22 10.8 0.9 3.3 7.0 0.3 2.5 2 0 0 2 2 2 0 Sirohaem biosynthesis protein C-terminal Helicase_C PF00271.26 KOO27278.1 - 9.6e-25 86.2 0.0 7.8e-24 83.3 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOO27278.1 - 5.2e-18 65.1 0.0 1.2e-17 63.8 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Rick_17kDa_Anti PF05433.10 KOO27278.1 - 0.78 9.4 6.7 2 8.1 4.7 1.7 1 0 0 1 1 1 0 Glycine zipper 2TM domain Myosin_head PF00063.16 KOO27279.1 - 7.5e-77 258.9 0.0 1.3e-42 145.7 0.0 4.1 2 1 2 4 4 4 4 Myosin head (motor domain) AAA_19 PF13245.1 KOO27279.1 - 0.0033 17.1 0.1 0.011 15.4 0.0 2.0 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 KOO27279.1 - 0.027 14.6 0.1 0.15 12.1 0.0 2.3 2 1 0 2 2 2 0 AAA domain UvrC_HhH_N PF08459.6 KOO27280.1 - 0.033 13.7 1.8 0.035 13.6 0.3 1.8 2 0 0 2 2 2 0 UvrC Helix-hairpin-helix N-terminal GABP-alpha PF11620.3 KOO27280.1 - 0.04 13.9 0.1 8.9 6.3 0.0 3.3 4 0 0 4 4 4 0 GA-binding protein alpha chain DrsE_2 PF13686.1 KOO27280.1 - 0.11 12.3 1.4 0.27 10.9 0.8 1.8 1 1 0 1 1 1 0 DsrE/DsrF/DrsH-like family Leucyl-specific PF14795.1 KOO27280.1 - 5.9 6.8 8.6 1.4 8.8 0.3 3.7 3 0 0 3 3 3 0 Leucine-tRNA synthetase-specific domain Pkinase PF00069.20 KOO27282.1 - 1.5e-58 198.0 0.0 1.8e-58 197.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27282.1 - 5.4e-35 120.7 0.0 7.5e-35 120.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO27282.1 - 2.7e-08 33.1 0.0 3.8e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO27282.1 - 0.00012 21.8 0.8 0.025 14.3 0.3 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.17 KOO27282.1 - 0.0062 15.8 0.0 0.0092 15.3 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 KOO27282.1 - 0.15 11.1 0.3 0.23 10.4 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1680 PF07944.7 KOO27283.1 - 0.044 12.0 0.0 0.048 11.9 0.0 1.1 1 0 0 1 1 1 0 Putative glycosyl hydrolase of unknown function (DUF1680) Ribosomal_S11 PF00411.14 KOO27285.1 - 1.2e-39 134.8 0.2 1.6e-39 134.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 DUF814 PF05670.8 KOO27285.1 - 0.013 15.3 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF814) Ion_trans PF00520.26 KOO27286.1 - 1.1e-78 263.0 22.3 1.2e-46 158.4 2.4 3.3 3 0 0 3 3 3 3 Ion transport protein PKD_channel PF08016.7 KOO27286.1 - 0.004 15.6 33.6 0.0073 14.7 1.1 5.6 5 1 1 6 6 6 4 Polycystin cation channel Ion_trans PF00520.26 KOO27287.1 - 7.7e-79 263.5 9.0 1e-49 168.4 0.0 2.1 2 0 0 2 2 2 2 Ion transport protein PKD_channel PF08016.7 KOO27287.1 - 0.0074 14.7 27.6 0.87 7.9 2.5 4.8 3 2 2 5 5 5 4 Polycystin cation channel RRM_1 PF00076.17 KOO27288.1 - 1e-51 172.4 0.0 4.8e-17 61.3 0.0 3.8 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO27288.1 - 6e-44 147.8 0.0 7.7e-14 51.4 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO27288.1 - 3.6e-21 74.7 0.1 4.2e-08 32.9 0.0 3.7 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAPS PF04499.10 KOO27288.1 - 0.023 13.3 3.5 0.026 13.1 2.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Cas_Cas2CT1978 PF09707.5 KOO27288.1 - 0.16 11.8 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas2CT1978) Trefoil PF00088.13 KOO27289.1 - 1.1e-11 44.2 1.6 2.3e-11 43.1 1.1 1.6 1 0 0 1 1 1 1 Trefoil (P-type) domain 2OG-FeII_Oxy_3 PF13640.1 KOO27289.1 - 5e-11 43.0 0.6 1.8e-10 41.2 0.4 1.9 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO27289.1 - 9.8e-05 21.9 3.8 0.00061 19.3 0.4 2.5 1 1 1 2 2 2 1 2OG-Fe(II) oxygenase superfamily Chromo PF00385.19 KOO27290.1 - 1.5e-10 40.5 0.3 1.5e-10 40.5 0.2 1.9 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Acetyltransf_7 PF13508.1 KOO27290.1 - 0.15 12.2 0.0 0.39 10.9 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain TLC PF03219.9 KOO27291.1 - 1.8e-05 23.4 12.0 0.00034 19.2 1.8 2.3 2 1 0 2 2 2 2 TLC ATP/ADP transporter Asp_Arg_Hydrox PF05118.10 KOO27292.1 - 3e-33 114.9 0.0 4.7e-33 114.3 0.0 1.3 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase Abhydrolase_5 PF12695.2 KOO27292.1 - 0.0013 18.5 0.5 0.0033 17.2 0.2 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO27292.1 - 0.0017 18.2 10.0 0.0054 16.6 6.9 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family UPF0227 PF05728.7 KOO27292.1 - 0.034 13.8 0.0 0.073 12.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) HSP70 PF00012.15 KOO27294.1 - 9.8e-68 228.5 0.1 9.4e-53 179.0 0.1 2.1 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 KOO27294.1 - 3.4e-05 22.6 1.0 0.00037 19.1 0.7 2.4 1 1 0 1 1 1 1 MreB/Mbl protein DP PF08781.5 KOO27294.1 - 0.028 14.1 0.0 0.047 13.3 0.0 1.3 1 0 0 1 1 1 0 Transcription factor DP Ion_trans_2 PF07885.11 KOO27295.1 - 0.014 15.1 1.8 0.023 14.3 1.3 1.4 1 0 0 1 1 1 0 Ion channel Adeno_terminal PF02459.10 KOO27296.1 - 0.2 9.7 0.1 0.35 8.9 0.1 1.3 1 0 0 1 1 1 0 Adenoviral DNA terminal protein Vint PF14623.1 KOO27297.1 - 0.00027 20.4 0.0 0.00063 19.2 0.0 1.6 1 0 0 1 1 1 1 Hint-domain Hint PF01079.15 KOO27297.1 - 0.045 12.9 0.0 0.085 12.0 0.0 1.4 1 0 0 1 1 1 0 Hint module SF3b1 PF08920.5 KOO27298.1 - 1.1e-32 113.1 0.1 2.2e-32 112.0 0.0 1.5 1 0 0 1 1 1 1 Splicing factor 3B subunit 1 HEAT_2 PF13646.1 KOO27298.1 - 1.1e-13 51.2 6.4 0.0037 17.5 0.0 7.8 6 3 4 10 10 10 6 HEAT repeats HEAT PF02985.17 KOO27298.1 - 1.3e-11 43.5 9.3 0.13 12.4 0.1 9.6 9 0 0 9 9 9 3 HEAT repeat HEAT_EZ PF13513.1 KOO27298.1 - 2.4e-08 34.2 6.5 0.99 9.9 0.0 7.9 8 1 1 9 9 9 3 HEAT-like repeat Adaptin_N PF01602.15 KOO27298.1 - 2.6e-05 22.7 1.5 0.0052 15.1 0.0 2.9 1 1 1 3 3 3 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.2 KOO27298.1 - 5.9e-05 23.3 0.2 0.29 11.5 0.0 5.0 5 0 0 5 5 5 1 Vacuolar 14 Fab1-binding region MMS19_N PF14500.1 KOO27298.1 - 0.0021 17.3 0.1 5.8 6.0 0.0 3.8 3 1 1 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II CLASP_N PF12348.3 KOO27298.1 - 0.0023 17.3 0.9 3.1 7.0 0.0 3.5 4 0 0 4 4 4 2 CLASP N terminal TIP120 PF08623.5 KOO27298.1 - 0.0028 17.2 0.1 0.36 10.3 0.0 2.9 2 0 0 2 2 2 1 TATA-binding protein interacting (TIP20) Arm PF00514.18 KOO27298.1 - 0.0077 16.0 3.4 9.5 6.2 0.0 5.4 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat UME PF08064.8 KOO27298.1 - 0.026 14.4 0.1 0.72 9.8 0.0 3.5 3 1 1 4 4 4 0 UME (NUC010) domain RPA_C PF08784.6 KOO27298.1 - 0.2 12.0 0.0 26 5.3 0.0 2.6 2 0 0 2 2 2 0 Replication protein A C terminal EzrA PF06160.7 KOO27299.1 - 0.0017 16.6 4.4 0.0024 16.1 3.0 1.2 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA EMP24_GP25L PF01105.19 KOO27299.1 - 0.052 13.2 0.6 0.11 12.1 0.0 1.7 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD STAT_alpha PF01017.15 KOO27299.1 - 0.29 10.8 5.9 0.5 10.0 4.1 1.4 1 0 0 1 1 1 0 STAT protein, all-alpha domain APG6 PF04111.7 KOO27299.1 - 1.8 7.5 7.4 2.7 6.9 5.1 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Striatin PF08232.7 KOO27299.1 - 2.4 8.4 8.9 4.2 7.6 6.1 1.3 1 0 0 1 1 1 0 Striatin family DEAD PF00270.24 KOO27300.1 - 6.8e-40 136.3 0.0 3.5e-39 133.9 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase CN_hydrolase PF00795.17 KOO27300.1 - 1.3e-26 93.0 0.0 2.9e-26 91.9 0.0 1.5 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Helicase_C PF00271.26 KOO27300.1 - 7.1e-25 86.6 0.0 1.4e-24 85.7 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 KOO27300.1 - 0.093 12.8 0.0 1 9.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain BTB_2 PF02214.17 KOO27301.1 - 5e-17 61.8 0.0 7.6e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.26 KOO27301.1 - 0.007 16.3 0.0 0.0099 15.8 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain EF-hand_1 PF00036.27 KOO27302.1 - 8.5e-12 43.4 0.6 4.6e-06 25.5 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO27302.1 - 2.6e-10 39.1 1.4 2.2e-05 23.5 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO27302.1 - 3.8e-10 38.7 0.9 0.00035 20.2 0.2 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO27302.1 - 6.7e-07 29.3 8.0 2.3e-06 27.6 5.6 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO27302.1 - 0.00093 18.7 0.1 0.043 13.4 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain pair Arm PF00514.18 KOO27302.1 - 0.096 12.5 3.0 0.18 11.6 0.1 2.9 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat LRR_6 PF13516.1 KOO27303.1 - 1.5e-44 145.0 0.1 0.00022 20.9 0.0 8.1 8 0 0 8 8 8 8 Leucine Rich repeat LRR_4 PF12799.2 KOO27303.1 - 1.8e-11 43.4 1.6 0.19 11.4 0.0 5.9 4 3 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO27303.1 - 7.9e-10 37.3 0.0 24 5.4 0.0 7.2 7 1 0 7 7 7 0 Leucine Rich Repeat SpoU_sub_bind PF08032.7 KOO27303.1 - 5.2e-08 32.9 9.9 0.017 15.2 0.1 5.7 2 1 4 6 6 6 3 RNA 2'-O ribose methyltransferase substrate binding LRR_7 PF13504.1 KOO27303.1 - 5.4e-06 25.7 5.2 12 6.6 0.0 7.1 8 0 0 8 8 8 1 Leucine rich repeat CbiG_N PF11760.3 KOO27303.1 - 6.7e-05 22.5 21.8 1.2 8.8 0.1 6.9 3 2 4 7 7 7 3 Cobalamin synthesis G N-terminal YycC PF14174.1 KOO27303.1 - 0.0001 21.8 0.0 13 5.5 0.0 6.1 7 0 0 7 7 7 1 YycC-like protein LRR_8 PF13855.1 KOO27303.1 - 0.00033 20.3 5.6 1.5 8.6 0.1 5.3 1 1 6 7 7 7 1 Leucine rich repeat DUF3107 PF11305.3 KOO27303.1 - 0.025 14.4 7.5 7.3 6.5 0.0 4.8 2 1 4 6 6 6 0 Protein of unknown function (DUF3107) DUF2202 PF09968.4 KOO27303.1 - 0.028 14.0 8.1 21 4.7 0.1 5.6 1 1 4 5 5 5 0 Uncharacterized protein domain (DUF2202) CTV_P13 PF06922.6 KOO27303.1 - 0.051 13.4 0.5 30 4.5 0.0 3.8 2 1 2 4 4 4 0 Citrus tristeza virus P13 protein EF-hand_1 PF00036.27 KOO27305.1 - 1.9e-26 89.2 4.8 2.9e-05 23.0 0.2 5.4 5 0 0 5 5 5 5 EF hand EF-hand_5 PF13202.1 KOO27305.1 - 1.9e-22 77.5 5.3 0.00027 20.1 0.1 5.5 5 0 0 5 5 5 5 EF hand EF-hand_7 PF13499.1 KOO27305.1 - 1.8e-21 76.0 1.7 1.7e-08 34.4 0.2 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO27305.1 - 1.9e-20 70.8 0.4 0.0095 15.7 0.0 5.5 5 0 0 5 5 5 5 EF-hand domain EF-hand_8 PF13833.1 KOO27305.1 - 6.5e-16 57.6 9.8 7.1e-07 28.7 1.2 4.7 3 2 2 5 5 5 4 EF-hand domain pair EF-hand_4 PF12763.2 KOO27305.1 - 0.0038 16.9 1.1 0.054 13.2 0.4 3.0 2 2 2 4 4 4 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO27305.1 - 0.21 11.4 0.2 2.8 7.9 0.0 2.9 2 1 1 3 3 3 0 EF-hand domain LRR_4 PF12799.2 KOO27307.1 - 0.077 12.6 2.3 1.9 8.1 0.2 2.7 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO27307.1 - 0.1 12.6 1.3 23 5.5 0.0 3.9 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.1 KOO27307.1 - 0.12 12.5 5.2 12 6.3 0.0 4.6 4 1 0 4 4 4 0 Leucine Rich repeat LRR_8 PF13855.1 KOO27307.1 - 1.1 9.0 3.4 8.5 6.2 0.6 2.8 2 1 1 3 3 3 0 Leucine rich repeat Glycos_transf_1 PF00534.15 KOO27308.1 - 2.9e-28 98.4 0.0 4.9e-28 97.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 KOO27308.1 - 2e-15 56.9 0.8 3.1e-15 56.3 0.6 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.1 KOO27308.1 - 3.4e-15 56.5 21.4 3.5e-15 56.4 9.6 2.7 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.1 KOO27308.1 - 2.2e-14 53.7 0.4 8.4e-14 51.8 0.2 2.0 3 0 0 3 3 3 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 KOO27308.1 - 7.1e-10 39.0 0.1 2.5e-09 37.2 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 DUF2493 PF10686.4 KOO27308.1 - 0.0084 15.6 0.1 0.026 14.0 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2493) VWA_CoxE PF05762.9 KOO27308.1 - 0.1 11.6 1.1 5.2 6.1 0.0 2.5 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein RelA_SpoT PF04607.12 KOO27310.1 - 1.4e-21 76.6 0.0 3.9e-21 75.2 0.0 1.8 1 1 0 1 1 1 1 Region found in RelA / SpoT proteins HD_4 PF13328.1 KOO27310.1 - 3.2e-08 33.4 0.1 1.7e-07 31.0 0.1 2.2 2 0 0 2 2 2 1 HD domain Helicase_C PF00271.26 KOO27311.1 - 7.8e-15 54.5 0.0 1.9e-14 53.2 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RQC PF09382.5 KOO27311.1 - 1.4e-05 24.7 0.0 3.4e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 RQC domain TAF8_C PF10406.4 KOO27313.1 - 0.0052 16.7 0.0 0.018 15.0 0.0 1.9 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term WLM PF08325.5 KOO27314.1 - 1.8e-21 76.9 0.0 1.8e-21 76.9 0.0 2.4 3 0 0 3 3 3 1 WLM domain DUF45 PF01863.12 KOO27314.1 - 4.9e-08 33.0 1.0 9.5e-08 32.0 0.7 1.4 1 0 0 1 1 1 1 Protein of unknown function DUF45 MEDS PF14417.1 KOO27314.1 - 0.00098 18.2 0.0 0.021 13.8 0.0 2.3 2 0 0 2 2 2 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain zf-RanBP PF00641.13 KOO27314.1 - 0.0011 18.0 14.2 0.11 11.6 1.5 2.4 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others NAAA-beta PF15508.1 KOO27314.1 - 0.039 14.3 0.0 0.092 13.1 0.0 1.5 1 0 0 1 1 1 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase DUF2072 PF09845.4 KOO27314.1 - 3.2 7.6 4.4 47 3.9 0.0 3.2 4 0 0 4 4 4 0 Zn-ribbon containing protein (DUF2072) Hist_deacetyl PF00850.14 KOO27315.1 - 9.7e-81 271.4 0.2 1.4e-80 270.8 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain N2227 PF07942.7 KOO27316.1 - 1.5e-76 256.9 0.0 2.3e-76 256.3 0.0 1.2 1 0 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.1 KOO27316.1 - 0.028 14.1 0.0 0.059 13.0 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain TTL PF03133.10 KOO27317.1 - 8.8e-44 149.5 0.0 2.1e-43 148.3 0.0 1.5 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 KOO27317.1 - 9.5e-05 21.3 0.0 0.058 12.1 0.0 2.3 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATP-grasp_4 PF13535.1 KOO27317.1 - 0.0011 18.7 0.0 0.0052 16.5 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_3 PF02655.9 KOO27317.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain Prp18 PF02840.10 KOO27318.1 - 5.6e-50 168.9 0.1 5.6e-50 168.9 0.1 1.5 2 0 0 2 2 2 1 Prp18 domain PRP4 PF08799.6 KOO27318.1 - 1.2e-12 46.8 0.9 3e-12 45.5 0.6 1.7 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Ank_4 PF13637.1 KOO27320.1 - 7.2e-16 58.2 1.2 0.00027 21.3 0.1 4.2 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO27320.1 - 7.9e-15 54.9 1.3 3.5e-11 43.2 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO27320.1 - 2.1e-14 52.4 3.4 2.5e-05 23.8 0.0 4.6 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.1 KOO27320.1 - 4.9e-08 32.4 2.6 2 8.8 0.0 5.7 5 2 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.1 KOO27320.1 - 3.1e-06 27.2 0.5 0.00047 20.3 0.1 3.8 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Cys_Met_Meta_PP PF01053.15 KOO27321.1 - 1.2e-114 382.6 0.0 1.8e-114 382.0 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 KOO27321.1 - 0.00028 19.9 0.0 0.00041 19.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 KOO27321.1 - 0.2 10.3 0.0 0.3 9.7 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V Ank_2 PF12796.2 KOO27322.1 - 2.7e-48 162.2 5.7 1.1e-16 60.8 0.0 3.9 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 KOO27322.1 - 5.6e-39 130.0 9.4 1.5e-08 34.0 0.0 6.3 6 0 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.1 KOO27322.1 - 3.3e-27 93.8 13.6 5.2e-09 36.0 0.1 5.3 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO27322.1 - 4.6e-27 91.3 2.3 0.00037 20.4 0.0 6.3 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.1 KOO27322.1 - 2.8e-25 88.2 7.2 9.5e-09 35.5 0.1 4.9 1 1 4 5 5 5 5 Ankyrin repeats (many copies) YCII PF03795.9 KOO27323.1 - 3.7e-08 33.4 0.0 3.7e-07 30.2 0.0 2.1 2 0 0 2 2 2 1 YCII-related domain ubiquitin PF00240.18 KOO27323.1 - 0.014 14.8 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin family Rad60-SLD PF11976.3 KOO27323.1 - 0.015 14.9 0.0 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like TUG-UBL1 PF11470.3 KOO27323.1 - 0.016 15.1 0.0 0.029 14.2 0.0 1.4 1 0 0 1 1 1 0 GLUT4 regulating protein TUG zf-CHCC PF10276.4 KOO27324.1 - 0.079 12.8 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Zinc-finger domain Motile_Sperm PF00635.21 KOO27325.1 - 1.8e-14 53.2 0.2 0.18 11.4 0.0 7.7 7 1 1 8 8 8 4 MSP (Major sperm protein) domain PapD-like PF14874.1 KOO27325.1 - 1.5e-09 37.7 0.0 0.47 10.4 0.0 7.9 9 0 0 9 9 9 3 Flagellar-associated PapD-like MYCBPAP PF14646.1 KOO27325.1 - 1.3e-07 30.7 0.0 0.0039 15.9 0.0 3.7 4 0 0 4 4 4 2 MYCBP-associated protein family DUF1573 PF07610.6 KOO27325.1 - 0.00073 19.0 4.8 3.8 7.1 0.1 5.6 5 0 0 5 5 5 1 Protein of unknown function (DUF1573) Lyase_1 PF00206.15 KOO27328.1 - 6.4e-93 311.3 0.0 8.6e-93 310.9 0.0 1.2 1 0 0 1 1 1 1 Lyase Abhydrolase_6 PF12697.2 KOO27328.1 - 2.9e-16 60.0 1.1 9.2e-16 58.4 0.8 2.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family ASL_C2 PF14698.1 KOO27328.1 - 8.5e-13 48.1 0.1 2e-12 46.9 0.1 1.6 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal DEK_C PF08766.6 KOO27328.1 - 0.0052 16.5 0.1 0.012 15.3 0.1 1.6 1 0 0 1 1 1 1 DEK C terminal domain Abhydrolase_1 PF00561.15 KOO27328.1 - 0.0071 15.9 0.0 0.019 14.4 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Ser_hydrolase PF06821.8 KOO27328.1 - 0.011 15.3 0.0 0.021 14.3 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase Methyltransf_24 PF13578.1 KOO27329.1 - 6.3e-11 43.0 0.0 6.3e-07 30.1 0.0 2.7 2 1 0 2 2 2 2 Methyltransferase domain CmcI PF04989.7 KOO27329.1 - 1.5e-06 27.7 0.0 5.5e-05 22.5 0.0 2.2 2 0 0 2 2 2 1 Cephalosporin hydroxylase Methyltransf_18 PF12847.2 KOO27329.1 - 0.0058 17.1 0.0 0.17 12.4 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Ribosomal_L19 PF01245.15 KOO27330.1 - 8.7e-11 41.6 0.0 1.2e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L19 BRE1 PF08647.6 KOO27331.1 - 3.2e-07 30.2 2.0 3.2e-07 30.2 1.4 8.9 3 2 8 11 11 11 1 BRE1 E3 ubiquitin ligase Reo_sigmaC PF04582.7 KOO27331.1 - 0.05 12.7 29.1 0.62 9.1 0.4 5.0 3 1 3 6 6 6 0 Reovirus sigma C capsid protein GAF PF01590.21 KOO27334.1 - 7.2e-34 117.1 3.9 4.1e-20 72.4 0.0 5.7 5 1 0 5 5 5 4 GAF domain GAF_3 PF13492.1 KOO27334.1 - 5.2e-30 104.1 0.9 2.2e-16 60.1 0.0 5.1 5 0 0 5 5 5 4 GAF domain GAF_2 PF13185.1 KOO27334.1 - 9.2e-26 91.1 1.7 7.8e-10 39.4 0.0 5.7 5 1 0 5 5 5 3 GAF domain DUF3369 PF11849.3 KOO27334.1 - 6.9e-05 22.8 1.0 0.00099 19.0 0.1 2.8 2 1 0 2 2 2 1 Domain of unknown function (DUF3369) Arm PF00514.18 KOO27335.1 - 1.1e-36 123.3 64.4 0.0003 20.4 0.3 18.5 19 0 0 19 19 19 12 Armadillo/beta-catenin-like repeat V-ATPase_H_N PF03224.9 KOO27335.1 - 0.0033 16.5 0.1 25 3.8 0.0 4.8 4 1 0 4 4 4 1 V-ATPase subunit H Arm_2 PF04826.8 KOO27335.1 - 0.0075 15.3 0.0 0.35 9.9 0.0 3.4 3 1 0 3 3 3 1 Armadillo-like RasGEF_N_2 PF14663.1 KOO27335.1 - 1.6 8.7 7.1 57 3.6 0.0 5.8 7 1 1 8 8 8 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain EF-hand_6 PF13405.1 KOO27336.1 - 1.4e-13 49.4 0.8 0.0036 17.0 0.2 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.27 KOO27336.1 - 2.1e-13 48.4 2.3 0.00061 18.9 0.0 4.1 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.1 KOO27336.1 - 4.8e-09 35.1 5.4 0.0053 16.0 0.1 4.0 5 0 0 5 5 5 2 EF hand EF-hand_7 PF13499.1 KOO27336.1 - 1e-08 35.1 2.5 2.9e-06 27.3 0.9 2.9 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO27336.1 - 8e-05 22.1 0.2 0.047 13.2 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair TMF_TATA_bd PF12325.3 KOO27336.1 - 0.14 11.8 3.8 0.25 11.0 2.6 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding ATP11 PF06644.6 KOO27336.1 - 0.64 9.4 8.4 1 8.7 5.8 1.3 1 0 0 1 1 1 0 ATP11 protein LUC7 PF03194.10 KOO27336.1 - 0.71 9.3 5.5 1.1 8.7 3.8 1.2 1 0 0 1 1 1 0 LUC7 N_terminus Glutaredoxin PF00462.19 KOO27337.1 - 0.0023 17.8 0.0 0.0042 17.0 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin Rib_recp_KP_reg PF05104.7 KOO27338.1 - 0.0013 19.2 11.3 0.0013 19.2 7.9 2.1 2 0 0 2 2 2 1 Ribosome receptor lysine/proline rich region SelP_N PF04592.9 KOO27338.1 - 0.034 13.5 7.6 0.051 12.9 5.3 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region FLO_LFY PF01698.11 KOO27338.1 - 0.38 9.5 10.5 0.63 8.8 7.3 1.3 1 0 0 1 1 1 0 Floricaula / Leafy protein Zip PF02535.17 KOO27338.1 - 2 7.3 8.9 2.8 6.8 6.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter amfpi-1 PF12190.3 KOO27339.1 - 0.11 12.9 0.5 0.58 10.6 0.0 2.3 2 1 1 3 3 3 0 Fungal protease inhibitor PhyH PF05721.8 KOO27340.1 - 5.2e-14 52.7 0.0 7.5e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) PTS_EIIC PF02378.13 KOO27340.1 - 0.11 11.3 0.2 0.16 10.7 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase system, EIIC YrhK PF14145.1 KOO27341.1 - 0.15 11.7 1.7 0.72 9.5 1.2 1.9 1 1 0 1 1 1 0 YrhK-like protein PIG-P PF08510.7 KOO27341.1 - 0.33 10.5 2.4 0.46 10.1 1.7 1.1 1 0 0 1 1 1 0 PIG-P Consortin_C PF15281.1 KOO27341.1 - 2.9 7.4 4.9 3.3 7.2 2.9 1.4 1 1 0 1 1 1 0 Consortin C-terminus LRR_4 PF12799.2 KOO27344.1 - 1.8e-22 78.4 6.0 8.4e-06 25.2 0.4 5.4 5 0 0 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO27344.1 - 7.4e-09 35.2 16.7 0.0045 16.7 0.5 4.3 3 1 0 4 4 4 3 Leucine rich repeat LRR_9 PF14580.1 KOO27344.1 - 1.8e-07 30.9 0.3 0.21 11.0 0.0 3.7 3 1 0 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.28 KOO27344.1 - 1.5e-05 24.3 13.6 3 8.2 0.1 7.4 8 1 1 9 9 9 1 Leucine Rich Repeat LRR_6 PF13516.1 KOO27344.1 - 9.1e-05 22.1 7.6 2.1 8.6 0.0 6.4 6 1 1 7 7 7 2 Leucine Rich repeat EF-hand_5 PF13202.1 KOO27344.1 - 0.0013 18.0 0.0 0.0031 16.7 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KOO27344.1 - 0.0025 16.9 0.0 0.0055 15.9 0.0 1.5 1 0 0 1 1 1 1 EF hand LRR_7 PF13504.1 KOO27344.1 - 0.0055 16.6 29.1 3.8 8.1 0.1 7.7 8 0 0 8 8 8 3 Leucine rich repeat EF-hand_6 PF13405.1 KOO27344.1 - 0.013 15.2 0.0 0.036 13.9 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.1 KOO27344.1 - 0.019 15.1 0.0 0.042 13.9 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair DUF3166 PF11365.3 KOO27345.1 - 2.1e-05 24.9 3.8 2.1e-05 24.9 2.6 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3166) DUF632 PF04782.7 KOO27345.1 - 0.0025 16.9 0.3 0.0047 16.0 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF632) Laminin_I PF06008.9 KOO27345.1 - 0.014 14.7 5.0 0.019 14.2 2.9 1.6 1 1 0 1 1 1 0 Laminin Domain I DUF904 PF06005.7 KOO27345.1 - 0.057 13.7 3.7 0.14 12.4 2.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF904) DUF972 PF06156.8 KOO27345.1 - 0.12 12.6 3.3 0.28 11.5 2.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF972) TMF_DNA_bd PF12329.3 KOO27345.1 - 0.29 10.9 8.5 0.9 9.3 5.9 1.8 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DivIVA PF05103.8 KOO27345.1 - 2.7 8.0 10.3 0.32 11.0 4.1 1.7 2 0 0 2 2 2 0 DivIVA protein APG6 PF04111.7 KOO27345.1 - 2.7 6.9 12.1 0.1 11.6 4.5 1.4 2 0 0 2 2 2 0 Autophagy protein Apg6 Speriolin_N PF15058.1 KOO27345.1 - 8.1 6.3 16.3 0.015 15.1 2.9 2.3 2 1 0 2 2 2 0 Speriolin N terminus OmpH PF03938.9 KOO27345.1 - 8.8 6.2 10.3 14 5.5 7.0 1.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) RPN7 PF10602.4 KOO27346.1 - 9.6e-44 148.8 1.1 1.4e-43 148.3 0.7 1.2 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.22 KOO27346.1 - 6.2e-09 36.1 0.0 1.2e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 PCI domain Abhydrolase_5 PF12695.2 KOO27347.1 - 7.4e-08 32.2 0.7 1.5e-07 31.3 0.5 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 KOO27347.1 - 1.1e-07 31.6 3.5 6.2e-07 29.2 2.4 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 KOO27347.1 - 0.0036 16.5 0.2 3 6.9 0.0 2.8 3 0 0 3 3 3 2 Prolyl oligopeptidase family LIP PF03583.9 KOO27347.1 - 0.012 14.8 0.4 0.27 10.3 0.0 2.1 2 0 0 2 2 2 0 Secretory lipase Abhydrolase_6 PF12697.2 KOO27347.1 - 0.47 10.3 12.4 1.6 8.5 6.8 2.7 1 1 1 2 2 2 0 Alpha/beta hydrolase family NUFIP1 PF10453.4 KOO27349.1 - 0.2 11.1 0.9 0.48 9.9 0.0 1.9 2 0 0 2 2 2 0 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) TPR_11 PF13414.1 KOO27350.1 - 2.6e-16 59.0 5.6 3.1e-11 42.7 0.9 3.1 2 1 0 2 2 2 2 TPR repeat TPR_1 PF00515.23 KOO27350.1 - 2e-11 42.9 8.3 0.0022 17.5 0.3 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.1 KOO27350.1 - 5.4e-06 26.1 8.5 0.00077 19.2 3.4 3.4 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO27350.1 - 6.4e-06 25.6 23.1 0.002 17.9 1.3 4.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO27350.1 - 0.027 15.1 0.9 0.027 15.1 0.6 3.9 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO27350.1 - 0.08 13.6 15.3 0.33 11.7 3.0 4.4 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO27350.1 - 0.35 10.8 0.1 0.28 11.1 1.1 3.9 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOO27350.1 - 1 9.3 4.4 7.2 6.6 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO27350.1 - 1.3 8.9 6.9 2.2 8.2 0.9 3.8 3 1 0 3 3 3 0 Tetratricopeptide repeat F-box-like PF12937.2 KOO27351.1 - 0.032 13.9 0.0 0.097 12.4 0.0 1.8 1 1 0 1 1 1 0 F-box-like DUF504 PF04457.7 KOO27352.1 - 0.0091 16.1 0.3 0.023 14.8 0.2 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF504) Cupin_4 PF08007.7 KOO27353.1 - 2.1e-13 50.2 0.1 1.2e-12 47.7 0.1 1.9 1 1 0 1 1 1 1 Cupin superfamily protein AAA_25 PF13481.1 KOO27354.1 - 0.0021 17.5 0.1 0.033 13.5 0.1 2.5 2 0 0 2 2 2 1 AAA domain EI24 PF07264.6 KOO27354.1 - 0.0027 17.1 0.7 0.0049 16.3 0.5 1.3 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) HEAT_EZ PF13513.1 KOO27354.1 - 0.033 14.6 1.0 0.033 14.6 0.7 2.7 2 0 0 2 2 2 0 HEAT-like repeat ATP-synt_8 PF00895.15 KOO27354.1 - 0.18 12.0 0.8 0.72 10.0 0.9 1.7 2 0 0 2 2 2 0 ATP synthase protein 8 TIG PF01833.19 KOO27355.1 - 6.3e-31 106.2 1.7 2.3e-05 24.3 0.0 7.3 7 1 0 7 7 7 5 IPT/TIG domain Kringle PF00051.13 KOO27355.1 - 4.3e-19 68.3 0.5 9.8e-19 67.2 0.3 1.6 1 0 0 1 1 1 1 Kringle domain Response_reg PF00072.19 KOO27358.1 - 8.2e-06 25.7 0.0 1.6e-05 24.8 0.0 1.6 1 1 0 1 1 1 1 Response regulator receiver domain ABC_tran PF00005.22 KOO27359.1 - 4.3e-52 176.0 0.0 4.7e-30 104.6 0.0 2.3 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 KOO27359.1 - 1.5e-21 77.6 0.0 5.4e-07 29.8 0.0 4.1 4 0 0 4 4 4 4 AAA domain ABC2_membrane_3 PF12698.2 KOO27359.1 - 5.8e-20 71.6 53.1 1.1e-14 54.2 13.3 2.7 3 0 0 3 3 3 2 ABC-2 family transporter protein SMC_N PF02463.14 KOO27359.1 - 1.9e-06 27.2 0.2 0.23 10.6 0.0 4.1 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.1 KOO27359.1 - 4.2e-05 23.3 0.0 0.1 12.5 0.0 3.5 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.1 KOO27359.1 - 0.00034 20.0 6.8 0.0055 16.1 0.5 2.9 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_23 PF13476.1 KOO27359.1 - 0.00049 20.4 1.0 0.56 10.4 0.1 2.2 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 KOO27359.1 - 0.0023 17.1 0.0 1.7 7.8 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_25 PF13481.1 KOO27359.1 - 0.017 14.5 0.5 1.7 7.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.12 KOO27359.1 - 0.021 14.2 1.3 3.3 7.1 0.0 3.3 4 0 0 4 4 4 0 IstB-like ATP binding protein PX PF00787.19 KOO27359.1 - 0.022 14.5 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 PX domain Zeta_toxin PF06414.7 KOO27359.1 - 0.053 12.6 0.2 7.9 5.5 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin AAA_22 PF13401.1 KOO27359.1 - 0.091 12.9 0.4 21 5.2 0.0 2.8 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.17 KOO27359.1 - 0.11 11.8 1.0 4.6 6.6 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_10 PF12846.2 KOO27359.1 - 0.92 8.8 1.0 6.2 6.1 0.0 2.2 2 0 0 2 2 2 0 AAA-like domain Ctr PF04145.10 KOO27360.1 - 0.0081 16.2 1.9 0.02 14.9 1.3 1.6 1 1 0 1 1 1 1 Ctr copper transporter family Patched PF02460.13 KOO27362.1 - 3.4e-10 38.5 21.0 0.00011 20.2 11.8 2.7 3 0 0 3 3 3 2 Patched family Peptidase_M41 PF01434.13 KOO27363.1 - 1.4e-16 60.6 0.0 1.5e-16 60.5 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M41 PMC2NT PF08066.7 KOO27363.1 - 0.044 14.0 0.3 0.17 12.1 0.2 1.7 1 1 0 1 1 1 0 PMC2NT (NUC016) domain DUF3018 PF11455.3 KOO27364.1 - 1.7 8.6 5.4 1.7 8.5 0.4 2.8 2 1 0 3 3 3 0 Protein of unknown function (DUF3018) Tautomerase PF01361.16 KOO27365.1 - 0.058 13.0 0.1 0.87 9.2 0.0 2.3 2 0 0 2 2 2 0 Tautomerase enzyme PIG-P PF08510.7 KOO27365.1 - 0.5 10.0 2.4 0.98 9.0 1.7 1.4 1 0 0 1 1 1 0 PIG-P LRR_6 PF13516.1 KOO27366.1 - 2.9e-28 94.7 41.5 0.02 14.9 0.1 17.5 18 0 0 18 18 18 9 Leucine Rich repeat LRR_1 PF00560.28 KOO27366.1 - 1.2e-15 55.0 22.1 2.1 8.7 0.0 13.7 15 1 0 15 15 15 5 Leucine Rich Repeat LRR_4 PF12799.2 KOO27366.1 - 2.9e-11 42.7 28.8 0.057 13.0 0.0 10.2 11 1 0 11 11 11 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO27366.1 - 1.3e-09 37.6 18.1 5.3 6.8 0.1 10.6 10 1 1 11 11 11 3 Leucine rich repeat LRR_7 PF13504.1 KOO27366.1 - 8.6e-09 34.1 32.1 6.1 7.5 0.3 12.2 13 0 0 13 13 13 3 Leucine rich repeat Plasmid_parti PF01672.11 KOO27366.1 - 0.15 12.4 0.3 1.1e+02 3.3 0.0 3.3 3 0 0 3 3 3 0 Putative plasmid partition protein FIBP PF05427.6 KOO27366.1 - 0.32 10.1 0.0 0.5 9.5 0.0 1.2 1 0 0 1 1 1 0 Acidic fibroblast growth factor binding (FIBP) RRM PF10378.4 KOO27367.1 - 0.053 13.1 0.9 0.12 12.0 0.6 1.7 1 0 0 1 1 1 0 Putative RRM domain Ribosomal_S15 PF00312.17 KOO27368.1 - 0.12 12.1 1.1 0.25 11.1 0.0 2.0 2 0 0 2 2 2 0 Ribosomal protein S15 PAN_4 PF14295.1 KOO27370.1 - 4.7e-08 32.6 7.5 4.7e-08 32.6 5.2 1.9 2 0 0 2 2 2 1 PAN domain Ion_trans PF00520.26 KOO27372.1 - 3.2e-157 519.4 58.1 7.8e-46 155.8 4.6 4.7 4 1 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 KOO27372.1 - 3.8e-09 35.4 63.4 1.9e-08 33.2 0.6 8.2 6 3 3 9 9 9 6 Polycystin cation channel EF-hand_1 PF00036.27 KOO27372.1 - 0.032 13.5 0.0 0.14 11.5 0.0 2.3 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.1 KOO27372.1 - 0.034 14.0 0.0 0.13 12.1 0.0 2.1 1 0 0 1 1 1 0 EF-hand domain VP9 PF09625.5 KOO27373.1 - 0.08 12.7 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 VP9 protein Cytochrom_B562 PF07361.6 KOO27373.1 - 1.1 9.6 15.7 0.16 12.3 5.8 2.8 2 1 1 3 3 3 0 Cytochrome b562 DEAD PF00270.24 KOO27374.1 - 7.6e-05 22.2 0.1 8.9e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase TPR_11 PF13414.1 KOO27375.1 - 1.1e-09 37.7 6.8 0.00027 20.5 0.0 5.2 2 1 3 5 5 5 2 TPR repeat TPR_17 PF13431.1 KOO27375.1 - 7.6e-06 25.7 0.0 0.74 10.1 0.0 4.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO27375.1 - 8.7e-05 22.8 28.2 0.024 15.2 0.1 6.8 5 1 2 7 7 7 3 Tetratricopeptide repeat Utp14 PF04615.8 KOO27375.1 - 0.0015 16.8 0.6 0.002 16.4 0.4 1.1 1 0 0 1 1 1 1 Utp14 protein TPR_16 PF13432.1 KOO27375.1 - 0.004 17.7 6.4 0.021 15.4 0.6 5.9 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO27375.1 - 0.0054 16.5 13.6 0.13 12.2 0.0 6.4 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO27375.1 - 0.37 11.1 0.0 0.37 11.1 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat Ax_dynein_light PF10211.4 KOO27376.1 - 8.8e-05 22.4 5.2 8.8e-05 22.4 3.6 3.0 2 1 0 3 3 3 1 Axonemal dynein light chain HrcA PF01628.16 KOO27376.1 - 0.015 14.9 0.4 0.015 14.9 0.3 2.4 2 1 1 3 3 3 0 HrcA protein C terminal domain DUF3584 PF12128.3 KOO27376.1 - 0.096 10.0 18.1 0.22 8.8 10.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) DUF972 PF06156.8 KOO27376.1 - 0.12 12.6 8.3 0.58 10.5 0.0 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF972) SMAP PF15477.1 KOO27376.1 - 0.19 12.0 5.8 0.72 10.1 0.0 3.7 3 0 0 3 3 3 0 Small acidic protein family V_ATPase_I PF01496.14 KOO27376.1 - 0.25 9.1 2.6 1.5 6.6 1.0 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family AAA_13 PF13166.1 KOO27376.1 - 0.78 8.1 5.0 0.71 8.2 1.7 2.0 2 0 0 2 2 2 0 AAA domain DUF3571 PF12095.3 KOO27376.1 - 4.3 7.6 8.3 2 8.7 0.6 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF3571) DUF342 PF03961.8 KOO27376.1 - 6.1 5.1 6.7 12 4.1 3.3 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF342) BBP1_C PF15272.1 KOO27376.1 - 6.2 6.3 11.8 1.9 7.9 0.0 2.7 3 0 0 3 3 3 0 Spindle pole body component BBP1, C-terminal RCC1 PF00415.13 KOO27377.1 - 2e-21 75.9 16.3 2.4e-10 40.4 0.0 5.2 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO27377.1 - 2.1e-13 49.4 27.5 1.2e-05 24.7 0.5 6.1 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat Methyltransf_26 PF13659.1 KOO27377.1 - 2.6 8.0 7.9 5.6 7.0 5.4 1.8 1 1 0 1 1 1 0 Methyltransferase domain Ax_dynein_light PF10211.4 KOO27378.1 - 1.9e-89 298.4 13.8 2.2e-89 298.2 9.6 1.0 1 0 0 1 1 1 1 Axonemal dynein light chain DUF2051 PF09738.4 KOO27378.1 - 0.00012 21.4 2.3 0.0002 20.7 1.6 1.4 1 0 0 1 1 1 1 Double stranded RNA binding protein (DUF2051) APG6 PF04111.7 KOO27378.1 - 0.0058 15.7 8.8 0.0081 15.2 6.1 1.3 1 0 0 1 1 1 1 Autophagy protein Apg6 OPA3 PF07047.7 KOO27378.1 - 0.0065 16.2 2.3 0.0065 16.2 1.6 2.1 2 0 0 2 2 2 1 Optic atrophy 3 protein (OPA3) Syntaxin-6_N PF09177.6 KOO27378.1 - 0.019 15.3 6.8 0.038 14.3 4.7 1.5 1 0 0 1 1 1 0 Syntaxin 6, N-terminal bZIP_2 PF07716.10 KOO27378.1 - 0.1 12.4 25.3 0.083 12.7 4.4 2.8 3 0 0 3 3 3 0 Basic region leucine zipper TMF_DNA_bd PF12329.3 KOO27378.1 - 0.13 12.1 18.7 0.3 10.9 5.4 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding EMP24_GP25L PF01105.19 KOO27378.1 - 0.2 11.3 3.3 0.3 10.7 2.3 1.3 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF342 PF03961.8 KOO27378.1 - 0.28 9.5 7.3 0.34 9.2 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Striatin PF08232.7 KOO27378.1 - 0.28 11.4 13.7 0.52 10.6 9.5 1.5 1 0 0 1 1 1 0 Striatin family DUF3373 PF11853.3 KOO27378.1 - 0.31 9.5 4.4 0.4 9.1 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) V_ATPase_I PF01496.14 KOO27378.1 - 0.36 8.6 4.2 0.45 8.3 2.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Mnd1 PF03962.10 KOO27378.1 - 0.42 10.2 12.4 0.85 9.2 8.6 1.5 1 0 0 1 1 1 0 Mnd1 family DivIC PF04977.10 KOO27378.1 - 0.79 9.2 18.1 0.087 12.3 5.9 2.9 2 1 1 3 3 3 0 Septum formation initiator EIAV_Rev PF11129.3 KOO27378.1 - 2.5 8.0 6.7 0.69 9.8 2.4 1.6 2 0 0 2 2 2 0 Rev protein of equine infectious anaemia virus Atg14 PF10186.4 KOO27378.1 - 2.9 6.7 10.8 3.8 6.3 7.5 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 NYD-SP28_assoc PF14775.1 KOO27378.1 - 3.8 7.2 9.5 3.7 7.3 0.9 2.7 2 0 0 2 2 2 0 Sperm tail C-terminal domain Spc24 PF08286.6 KOO27378.1 - 4 7.1 9.9 9 6.0 6.6 1.8 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Fmp27_WPPW PF10359.4 KOO27378.1 - 4.1 5.7 9.5 5.1 5.4 6.6 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain GrpE PF01025.14 KOO27378.1 - 4.9 6.6 13.6 10 5.6 9.4 1.5 1 0 0 1 1 1 0 GrpE DUF724 PF05266.9 KOO27378.1 - 7.4 6.1 14.1 1.7 8.2 7.6 1.5 2 0 0 2 2 1 0 Protein of unknown function (DUF724) Peptidase_S41 PF03572.13 KOO27380.1 - 1.2e-37 128.8 0.0 1.8e-37 128.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S41 PDZ_2 PF13180.1 KOO27380.1 - 1.2e-06 28.3 0.0 2.4e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.19 KOO27380.1 - 3.4e-05 23.9 0.0 7.5e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Tricorn_C1 PF14684.1 KOO27380.1 - 0.00045 20.0 0.1 0.00085 19.1 0.1 1.4 1 0 0 1 1 1 1 Tricorn protease C1 domain GRASP55_65 PF04495.9 KOO27380.1 - 0.03 14.3 0.0 0.059 13.3 0.0 1.4 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain Thioredoxin_6 PF13848.1 KOO27381.1 - 8.8e-14 51.7 0.0 1.4e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain Calreticulin PF00262.13 KOO27381.1 - 1.5e-06 27.1 0.0 2.5e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Calreticulin family DUF1183 PF06682.7 KOO27381.1 - 0.14 11.7 0.8 0.31 10.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1183) GRA6 PF05084.8 KOO27381.1 - 0.17 11.4 3.1 0.32 10.4 2.1 1.4 1 0 0 1 1 1 0 Granule antigen protein (GRA6) Glyco_transf_28 PF03033.15 KOO27382.1 - 4.8e-17 62.0 0.2 1.6e-16 60.3 0.1 1.9 2 0 0 2 2 2 1 Glycosyltransferase family 28 N-terminal domain PaREP1 PF05942.6 KOO27382.1 - 0.029 14.2 0.2 0.066 13.0 0.1 1.7 1 1 0 1 1 1 0 Archaeal PaREP1/PaREP8 family DUF4112 PF13430.1 KOO27382.1 - 0.03 14.2 0.5 0.06 13.2 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4112) DUF412 PF04217.8 KOO27382.1 - 0.14 11.9 0.9 0.37 10.5 0.6 1.7 1 1 0 1 1 1 0 Protein of unknown function, DUF412 Dus PF01207.12 KOO27383.1 - 4.4e-53 180.1 0.0 1.4e-52 178.4 0.0 1.7 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) EF-hand_7 PF13499.1 KOO27384.1 - 0.14 12.3 0.1 0.31 11.2 0.1 1.5 1 0 0 1 1 1 0 EF-hand domain pair Myb_DNA-binding PF00249.26 KOO27386.1 - 2.3e-32 110.7 2.3 3.4e-16 59.0 0.0 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO27386.1 - 1.3e-23 82.8 0.1 4.5e-14 52.2 0.0 2.2 1 1 1 2 2 2 2 Myb-like DNA-binding domain Rap1_C PF11626.3 KOO27386.1 - 0.0013 18.5 0.6 0.94 9.4 0.2 2.3 1 1 1 2 2 2 2 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_2 PF08914.6 KOO27386.1 - 0.0015 18.2 1.6 0.17 11.6 0.2 3.0 1 1 1 2 2 2 1 Rap1 Myb domain Myb_DNA-bind_4 PF13837.1 KOO27386.1 - 0.055 13.5 0.8 7.7 6.7 0.0 2.5 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Dus PF01207.12 KOO27387.1 - 6e-56 189.5 0.0 7.9e-56 189.1 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) PEP_mutase PF13714.1 KOO27387.1 - 0.016 14.4 1.1 0.082 12.1 0.0 2.2 2 0 0 2 2 2 0 Phosphoenolpyruvate phosphomutase UCH PF00443.24 KOO27388.1 - 2.2e-50 171.3 0.0 2.6e-50 171.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOO27388.1 - 1.8e-18 67.0 0.0 3.1e-18 66.2 0.0 1.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.18 KOO27388.1 - 2.9e-06 26.5 0.0 6.7e-06 25.4 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family YukD PF08817.5 KOO27388.1 - 0.0039 17.7 0.0 0.0099 16.4 0.0 1.8 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD Peptidase_C98 PF15499.1 KOO27388.1 - 0.15 11.3 0.0 0.7 9.1 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase LRR_4 PF12799.2 KOO27389.1 - 8.2e-23 79.5 6.9 3.4e-05 23.3 0.0 6.4 5 1 2 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO27389.1 - 1.7e-21 75.6 9.5 1.1e-08 34.6 0.2 5.1 5 0 0 5 5 5 4 Leucine rich repeat LRR_1 PF00560.28 KOO27389.1 - 1.5e-17 60.9 8.9 0.19 11.8 0.0 8.5 8 0 0 8 8 8 6 Leucine Rich Repeat LRR_7 PF13504.1 KOO27389.1 - 1.2e-09 36.7 12.5 0.64 10.4 0.0 8.2 8 0 0 8 8 8 3 Leucine rich repeat LRR_6 PF13516.1 KOO27389.1 - 8.8e-05 22.1 10.4 30 5.1 0.0 7.8 8 0 0 8 8 8 0 Leucine Rich repeat CK_II_beta PF01214.13 KOO27389.1 - 0.097 12.1 0.0 2.2 7.7 0.0 2.1 2 0 0 2 2 2 0 Casein kinase II regulatory subunit DUF3389 PF11869.3 KOO27389.1 - 0.16 11.8 0.7 1.4 8.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3389) Beta_helix PF13229.1 KOO27391.1 - 1.7e-23 83.1 0.0 1.4e-15 57.4 0.0 2.3 1 1 1 2 2 2 2 Right handed beta helix region TRM PF02005.11 KOO27391.1 - 6.3e-21 74.7 0.0 1.7e-10 40.3 0.0 2.2 2 0 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase NosD PF05048.8 KOO27391.1 - 1.9e-12 46.8 0.0 7.6e-08 31.7 0.0 2.1 1 1 1 2 2 2 2 Periplasmic copper-binding protein (NosD) DUF1565 PF07602.6 KOO27391.1 - 9.7e-05 21.6 0.1 0.047 12.8 0.0 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF1565) Pectate_lyase_3 PF12708.2 KOO27391.1 - 0.00019 21.6 0.0 0.064 13.3 0.0 2.3 2 0 0 2 2 2 2 Pectate lyase superfamily protein Adeno_E1B_55K PF01696.12 KOO27391.1 - 0.014 13.8 6.2 0.17 10.3 0.1 2.3 2 0 0 2 2 2 0 Adenovirus EB1 55K protein / large t-antigen Bromodomain PF00439.20 KOO27392.1 - 4.6e-11 42.4 0.0 8.5e-11 41.6 0.0 1.4 1 0 0 1 1 1 1 Bromodomain HMG_box PF00505.14 KOO27392.1 - 6.2e-08 32.7 3.7 1.7e-07 31.4 2.5 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO27392.1 - 1.2e-06 28.8 3.9 3.1e-06 27.4 2.7 1.8 1 0 0 1 1 1 1 HMG-box domain Myc_N PF01056.13 KOO27392.1 - 0.002 17.3 5.8 0.002 17.3 4.0 3.1 2 1 1 3 3 3 1 Myc amino-terminal region Cut8_N PF14482.1 KOO27392.1 - 0.047 13.6 2.3 0.26 11.3 0.6 2.8 2 0 0 2 2 2 0 Cut8 proteasome-binding domain Spore_coat_CotO PF14153.1 KOO27392.1 - 3.8 6.9 18.0 1.6 8.1 4.4 2.7 2 0 0 2 2 2 0 Spore coat protein CotO CDC45 PF02724.9 KOO27392.1 - 4.5 5.1 18.0 0.4 8.6 3.7 2.3 2 0 0 2 2 2 0 CDC45-like protein Ion_trans_2 PF07885.11 KOO27393.1 - 1.7e-26 91.7 22.8 3.7e-13 48.9 6.8 2.4 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.26 KOO27393.1 - 0.018 14.3 10.3 0.045 13.0 0.5 2.4 2 0 0 2 2 2 0 Ion transport protein DUF3452 PF11934.3 KOO27393.1 - 0.16 11.3 0.4 0.34 10.2 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3452) DHO_dh PF01180.16 KOO27394.1 - 2.5e-31 108.7 0.0 6.6e-31 107.3 0.0 1.6 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase Cupin_4 PF08007.7 KOO27396.1 - 2.2e-20 73.1 0.0 7e-20 71.5 0.0 1.8 1 1 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.1 KOO27396.1 - 2.7e-09 36.9 0.0 2.2e-08 33.9 0.0 1.9 1 1 0 1 1 1 1 Cupin-like domain Cupin_2 PF07883.6 KOO27396.1 - 0.16 11.4 0.0 0.45 10.0 0.0 1.7 1 0 0 1 1 1 0 Cupin domain Neur_chan_memb PF02932.11 KOO27397.1 - 3.6e-08 33.6 12.6 1.8e-07 31.2 3.5 2.6 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region RR_TM4-6 PF06459.7 KOO27397.1 - 0.015 15.1 10.3 0.033 14.0 7.1 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DivIVA PF05103.8 KOO27397.1 - 0.23 11.5 12.9 0.38 10.8 8.9 1.3 1 0 0 1 1 1 0 DivIVA protein Vfa1 PF08432.5 KOO27397.1 - 0.58 10.1 13.0 1.1 9.2 9.0 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF3464 PF11947.3 KOO27397.1 - 3.1 7.2 6.6 10 5.5 4.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) ADK PF00406.17 KOO27398.1 - 0.072 12.9 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Adenylate kinase cobW PF02492.14 KOO27400.1 - 8.6e-22 77.4 0.1 1.2e-21 76.9 0.1 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MORN PF02493.15 KOO27401.1 - 5.2e-22 76.2 17.0 2.1e-07 30.2 0.8 4.2 4 0 0 4 4 4 3 MORN repeat cobW PF02492.14 KOO27401.1 - 4.3e-17 62.1 0.0 6.6e-17 61.5 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.1 KOO27401.1 - 0.00057 19.9 0.0 0.0015 18.5 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 KOO27401.1 - 0.0008 19.5 0.0 0.0021 18.1 0.0 1.6 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 KOO27401.1 - 0.0057 15.8 0.0 0.0089 15.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_14 PF13173.1 KOO27401.1 - 0.011 15.6 0.0 0.016 15.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 KOO27401.1 - 0.019 14.6 0.0 0.028 14.1 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase UPF0079 PF02367.12 KOO27401.1 - 0.021 14.4 0.5 0.066 12.8 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 T2SE PF00437.15 KOO27401.1 - 0.021 13.7 0.0 0.032 13.1 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein MobB PF03205.9 KOO27401.1 - 0.039 13.6 0.0 0.24 11.1 0.0 2.1 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.22 KOO27401.1 - 0.048 13.9 0.0 0.12 12.7 0.0 1.6 2 0 0 2 2 1 0 ABC transporter AAA_33 PF13671.1 KOO27401.1 - 0.061 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 KOO27401.1 - 0.078 12.7 1.1 0.39 10.5 0.0 2.4 2 0 0 2 2 2 0 Part of AAA domain AAA_29 PF13555.1 KOO27401.1 - 0.096 12.2 0.5 0.39 10.2 0.2 2.1 1 1 1 2 2 2 0 P-loop containing region of AAA domain Zeta_toxin PF06414.7 KOO27401.1 - 0.11 11.6 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Viral_helicase1 PF01443.13 KOO27401.1 - 0.12 11.9 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF3188 PF11384.3 KOO27401.1 - 0.12 11.9 1.4 0.17 11.4 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3188) SRPRB PF09439.5 KOO27401.1 - 0.18 10.9 0.0 0.31 10.2 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit F_bP_aldolase PF01116.15 KOO27402.1 - 2.5e-43 148.2 0.0 1.3e-41 142.6 0.0 2.2 1 1 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Aminotran_1_2 PF00155.16 KOO27403.1 - 9.6e-32 110.3 0.0 1.1e-31 110.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 KOO27403.1 - 1e-06 28.1 0.0 1.4e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 KOO27403.1 - 7e-05 22.0 0.1 0.00068 18.7 0.1 2.0 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.15 KOO27403.1 - 0.00023 19.5 0.0 0.00033 19.0 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Alliinase_C PF04864.8 KOO27403.1 - 0.00048 18.9 0.0 0.00069 18.3 0.0 1.2 1 0 0 1 1 1 1 Allinase Aminotran_5 PF00266.14 KOO27403.1 - 0.0014 17.4 0.0 0.002 16.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DUF4072 PF13284.1 KOO27403.1 - 0.015 15.4 0.0 0.059 13.5 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4072) VirE PF05272.6 KOO27403.1 - 0.093 12.1 0.0 0.33 10.4 0.0 1.8 2 0 0 2 2 2 0 Virulence-associated protein E CR6_interact PF10147.4 KOO27404.1 - 0.00037 19.8 0.9 0.00049 19.4 0.6 1.3 1 0 0 1 1 1 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 DUF2746 PF10874.3 KOO27407.1 - 0.04 14.1 0.7 0.11 12.7 0.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2746) IL10 PF00726.12 KOO27407.1 - 0.075 12.3 2.4 0.1 11.8 0.4 1.9 2 0 0 2 2 2 0 Interleukin 10 Fea1 PF07692.6 KOO27407.1 - 0.098 11.4 1.6 0.14 10.9 0.3 1.7 1 1 1 2 2 2 0 Low iron-inducible periplasmic protein AATF-Che1 PF13339.1 KOO27407.1 - 0.3 11.2 18.0 2.4 8.3 8.1 2.2 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor YqjK PF13997.1 KOO27407.1 - 0.83 9.8 0.0 0.83 9.8 0.0 2.3 2 0 0 2 2 2 0 YqjK-like protein DUF3280 PF11684.3 KOO27407.1 - 0.88 9.7 15.1 0.07 13.3 2.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2380) Peptidase_S46 PF10459.4 KOO27407.1 - 1.6 7.0 8.1 0.12 10.7 2.3 1.5 2 0 0 2 2 2 0 Peptidase S46 DUF445 PF04286.7 KOO27407.1 - 1.7 8.0 10.1 2.2 7.7 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) DUF4616 PF15394.1 KOO27407.1 - 2.5 6.9 10.6 1.6 7.6 6.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4616) IncA PF04156.9 KOO27407.1 - 3.5 7.1 27.5 1.3 8.6 9.2 2.2 2 0 0 2 2 2 0 IncA protein HemX PF04375.9 KOO27407.1 - 4.4 5.7 24.9 6.6 5.2 11.4 2.1 1 1 1 2 2 2 0 HemX Asp-B-Hydro_N PF05279.6 KOO27407.1 - 4.6 7.0 14.6 0.28 10.9 6.3 1.7 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region DUF3573 PF12097.3 KOO27407.1 - 4.7 5.7 9.2 0.21 10.1 1.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3573) Rootletin PF15035.1 KOO27407.1 - 7.1 6.5 26.7 17 5.2 18.3 1.6 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF3897 PF13036.1 KOO27407.1 - 8.8 5.9 12.9 0.42 10.1 3.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3897) DUF3656 PF12392.3 KOO27407.1 - 9.7 6.2 13.1 0.48 10.4 1.1 2.7 2 1 1 3 3 3 0 Collagenase Nucleotid_trans PF03407.11 KOO27408.1 - 3.3e-35 121.7 0.0 4.7e-35 121.2 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase FimP PF09766.4 KOO27410.1 - 2.7e-35 122.0 0.8 3.6e-35 121.6 0.6 1.1 1 0 0 1 1 1 1 Fms-interacting protein Sigma70_r1_2 PF00140.15 KOO27410.1 - 4 7.2 5.9 9.6 5.9 0.4 3.0 3 0 0 3 3 3 0 Sigma-70 factor, region 1.2 PDEase_I PF00233.14 KOO27411.1 - 7e-50 169.9 0.0 4e-49 167.5 0.0 1.8 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase Lipase PF00151.14 KOO27411.1 - 0.14 11.2 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Lipase PDZ PF00595.19 KOO27412.1 - 1.2e-08 34.9 0.0 2.2e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Abhydrolase_5 PF12695.2 KOO27412.1 - 0.0039 16.9 0.0 0.011 15.5 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Adeno_E3_CR2 PF02439.10 KOO27412.1 - 0.1 12.1 0.3 0.22 11.0 0.2 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 PDZ_2 PF13180.1 KOO27412.1 - 0.11 12.3 0.1 0.23 11.3 0.1 1.4 1 0 0 1 1 1 0 PDZ domain YihI PF04220.7 KOO27412.1 - 0.18 11.1 0.0 0.29 10.4 0.0 1.2 1 0 0 1 1 1 0 Der GTPase activator (YihI) HCMV_UL139 PF12507.3 KOO27413.1 - 0.0039 17.3 3.1 0.0039 17.3 2.1 2.8 1 1 1 2 2 2 1 Human Cytomegalovirus UL139 protein Cep57_CLD_2 PF14197.1 KOO27413.1 - 0.018 14.9 4.6 0.018 14.9 3.2 3.1 3 1 0 3 3 3 0 Centrosome localisation domain of PPC89 MDFI PF15316.1 KOO27413.1 - 0.67 9.9 5.8 0.23 11.4 1.4 1.9 1 1 1 2 2 2 0 MyoD family inhibitor Lge1 PF11488.3 KOO27413.1 - 1.6 8.9 8.5 0.25 11.5 1.4 2.7 2 2 0 2 2 2 0 Transcriptional regulatory protein LGE1 Patched PF02460.13 KOO27414.1 - 0.13 10.1 11.7 0.05 11.5 3.3 2.1 2 0 0 2 2 2 0 Patched family Wzy_C PF04932.10 KOO27414.1 - 2 8.1 12.1 0.33 10.7 2.5 2.3 2 0 0 2 2 2 0 O-Antigen ligase PI3_PI4_kinase PF00454.22 KOO27415.1 - 3.6e-22 78.9 0.0 6.1e-21 74.9 0.0 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PH PF00169.24 KOO27415.1 - 1.1e-14 54.5 0.0 2.3e-14 53.4 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_9 PF15410.1 KOO27415.1 - 1.1e-07 31.9 0.0 2.2e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.1 KOO27415.1 - 2.2e-05 24.6 0.2 6e-05 23.2 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain Patatin PF01734.17 KOO27415.1 - 0.0049 16.8 0.8 0.37 10.6 0.6 2.9 1 1 0 1 1 1 1 Patatin-like phospholipase Beta-lactamase PF00144.19 KOO27416.1 - 6.2e-14 51.7 0.2 2.3e-13 49.8 0.2 1.9 1 1 0 1 1 1 1 Beta-lactamase AA_kinase PF00696.23 KOO27417.1 - 2.5e-49 168.0 0.0 4.5e-49 167.1 0.0 1.4 1 0 0 1 1 1 1 Amino acid kinase family ACT PF01842.20 KOO27417.1 - 4.1e-10 38.9 1.0 1e-06 28.0 0.1 2.5 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.1 KOO27417.1 - 1.4e-05 24.4 2.0 0.0019 17.6 0.5 2.5 2 0 0 2 2 2 2 ACT domain EF-hand_1 PF00036.27 KOO27418.1 - 7.1e-23 78.1 2.2 0.0001 21.3 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO27418.1 - 4.4e-21 72.8 5.2 0.0008 19.0 0.0 5.0 4 1 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO27418.1 - 1e-17 63.9 2.9 4.5e-08 33.1 0.2 3.6 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO27418.1 - 1.5e-14 53.2 0.9 3e-05 23.5 0.1 3.7 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO27418.1 - 4.9e-07 28.8 6.3 0.54 9.7 0.0 5.4 5 0 0 5 5 5 2 EF hand EF-hand_9 PF14658.1 KOO27418.1 - 0.002 17.9 0.0 1.7 8.5 0.0 3.8 4 0 0 4 4 4 1 EF-hand domain PMBR PF09373.5 KOO27418.1 - 0.028 14.3 0.5 86 3.3 0.0 4.1 4 0 0 4 4 4 0 Pseudomurein-binding repeat YppF PF14178.1 KOO27418.1 - 0.12 11.9 0.0 0.95 9.0 0.0 2.2 2 0 0 2 2 2 0 YppF-like protein Ion_trans PF00520.26 KOO27419.1 - 9e-88 292.7 19.0 1.9e-49 167.6 0.2 2.2 2 0 0 2 2 2 2 Ion transport protein PKD_channel PF08016.7 KOO27419.1 - 0.0037 15.7 32.6 0.43 8.9 0.1 5.0 3 1 1 4 4 4 3 Polycystin cation channel TIM21 PF08294.6 KOO27419.1 - 0.023 14.3 0.8 12 5.5 0.0 3.3 3 0 0 3 3 3 0 TIM21 DUF1180 PF06679.7 KOO27419.1 - 0.28 11.0 2.4 0.82 9.5 1.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Conotoxin PF02950.12 KOO27419.1 - 0.81 10.5 2.1 22 5.9 0.0 3.3 3 0 0 3 3 3 0 Conotoxin Syntaxin-6_N PF09177.6 KOO27422.1 - 1.1e-15 57.7 3.4 9.9e-15 54.7 0.3 2.5 2 1 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.14 KOO27422.1 - 5.8e-10 38.7 4.8 5.8e-10 38.7 3.3 2.4 3 0 0 3 3 3 1 SNARE domain Macoilin PF09726.4 KOO27422.1 - 0.16 10.2 8.6 0.22 9.7 6.0 1.2 1 1 0 1 1 1 0 Transmembrane protein Bacillus_HBL PF05791.6 KOO27422.1 - 0.2 10.9 2.7 0.18 11.1 0.9 1.5 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Prominin PF05478.6 KOO27422.1 - 0.5 7.8 2.6 0.57 7.6 0.3 1.9 2 0 0 2 2 2 0 Prominin SlyX PF04102.7 KOO27422.1 - 1.9 8.9 5.6 23 5.4 2.1 3.3 2 1 0 2 2 2 0 SlyX Mis14 PF08641.7 KOO27422.1 - 2.6 8.0 6.8 0.4 10.7 1.5 1.9 2 1 0 2 2 2 0 Kinetochore protein Mis14 like Aminotran_3 PF00202.16 KOO27423.1 - 6.7e-15 54.7 0.1 1.7e-13 50.1 0.0 2.2 1 1 0 1 1 1 1 Aminotransferase class-III GTP1_OBG PF01018.17 KOO27424.1 - 3.8e-48 163.0 5.2 7.2e-48 162.1 3.6 1.5 1 0 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.18 KOO27424.1 - 1.4e-20 73.3 0.0 2.4e-20 72.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF1967 PF09269.6 KOO27424.1 - 1.4e-17 63.0 0.0 3e-17 62.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1967) FeoB_N PF02421.13 KOO27424.1 - 1.1e-08 34.5 0.0 2.9e-08 33.1 0.0 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 KOO27424.1 - 0.00073 19.0 0.0 0.062 12.7 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Miro PF08477.8 KOO27424.1 - 0.0012 19.3 0.0 0.0023 18.4 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein ArgK PF03308.11 KOO27424.1 - 0.012 14.3 0.1 1.9 7.1 0.0 2.2 2 0 0 2 2 2 0 ArgK protein ATP_bind_1 PF03029.12 KOO27424.1 - 0.099 12.1 0.0 1.5 8.2 0.0 2.2 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein ABC_tran PF00005.22 KOO27424.1 - 0.12 12.6 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 ABC transporter TAP_C PF03943.8 KOO27424.1 - 0.14 11.5 0.1 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 TAP C-terminal domain DnaJ PF00226.26 KOO27425.1 - 6.1e-12 45.0 0.0 1e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain Rhodanese PF00581.15 KOO27425.1 - 1.5e-09 38.2 0.0 2.4e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain HhH-GPD PF00730.20 KOO27428.1 - 1.3e-14 54.3 0.0 1.9e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NeA_P2 PF12312.3 KOO27428.1 - 0.029 13.6 0.0 0.041 13.1 0.0 1.2 1 0 0 1 1 1 0 Nepovirus subgroup A polyprotein AAA_27 PF13514.1 KOO27429.1 - 0.02 12.5 0.5 0.022 12.4 0.4 1.0 1 0 0 1 1 1 0 AAA domain Atg14 PF10186.4 KOO27430.1 - 0.0036 16.3 5.1 0.0036 16.3 3.5 4.7 4 1 1 5 5 5 1 UV radiation resistance protein and autophagy-related subunit 14 NPV_P10 PF05531.7 KOO27430.1 - 0.12 12.6 3.2 2.3 8.5 0.2 3.6 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.5 KOO27430.1 - 0.41 10.7 5.0 4.9 7.2 0.4 2.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Reo_sigmaC PF04582.7 KOO27430.1 - 1.1 8.3 16.4 1.1 8.3 0.9 3.9 3 1 1 4 4 4 0 Reovirus sigma C capsid protein CASP_C PF08172.7 KOO27430.1 - 1.7 7.6 28.8 0.037 13.0 4.2 4.6 3 1 0 3 3 3 0 CASP C terminal Baculo_PEP_C PF04513.7 KOO27430.1 - 1.9 8.3 10.9 0.8 9.5 1.1 3.9 2 2 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus FlaC_arch PF05377.6 KOO27430.1 - 3 7.8 6.0 35 4.3 0.6 4.5 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) FlxA PF14282.1 KOO27430.1 - 5.1 7.1 13.5 84 3.1 6.4 4.1 2 1 1 3 3 3 0 FlxA-like protein Occludin_ELL PF07303.8 KOO27430.1 - 5.7 7.7 17.0 0.068 13.9 1.4 4.3 5 0 0 5 5 5 0 Occludin homology domain cNMP_binding PF00027.24 KOO27432.1 - 1.9e-17 62.8 0.1 4.2e-17 61.7 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Abhydrolase_5 PF12695.2 KOO27433.1 - 7.6e-12 45.2 0.2 9.9e-12 44.8 0.2 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 KOO27433.1 - 8e-08 31.4 0.0 1.2e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_6 PF12697.2 KOO27433.1 - 1.1e-05 25.4 4.2 0.014 15.2 1.4 2.4 1 1 1 2 2 2 2 Alpha/beta hydrolase family Chlorophyllase PF07224.6 KOO27433.1 - 0.00044 19.1 0.0 0.00075 18.3 0.0 1.3 1 1 0 1 1 1 1 Chlorophyllase Peptidase_S9 PF00326.16 KOO27433.1 - 0.00088 18.5 0.3 0.38 9.9 0.0 2.3 1 1 1 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.13 KOO27433.1 - 0.0039 16.5 0.0 0.0061 15.8 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.8 KOO27433.1 - 0.013 15.0 0.0 0.019 14.5 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold PAF-AH_p_II PF03403.8 KOO27433.1 - 0.015 13.6 0.6 0.62 8.2 0.0 2.1 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II FSH1 PF03959.8 KOO27433.1 - 0.029 13.8 0.0 0.04 13.3 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Metallophos PF00149.23 KOO27434.1 - 5.8e-27 94.3 1.0 9.7e-27 93.6 0.7 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase EF-hand_7 PF13499.1 KOO27434.1 - 1.1e-14 54.2 0.0 1.1e-05 25.4 0.0 4.5 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.27 KOO27434.1 - 1.8e-12 45.5 0.0 0.0011 18.0 0.0 6.6 7 0 0 7 7 7 2 EF hand EF-hand_6 PF13405.1 KOO27434.1 - 7.1e-12 44.1 0.1 0.011 15.5 0.0 6.0 7 0 0 7 7 7 2 EF-hand domain EF-hand_8 PF13833.1 KOO27434.1 - 8.6e-09 34.8 0.5 0.19 11.3 0.1 5.7 6 1 1 7 7 7 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO27434.1 - 0.00047 19.3 0.4 0.59 9.5 0.0 3.9 4 0 0 4 4 4 2 EF hand Metallophos_2 PF12850.2 KOO27434.1 - 0.00073 19.3 0.0 0.0012 18.6 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain CorA PF01544.13 KOO27435.1 - 4.5 6.2 22.2 0.47 9.4 5.5 2.5 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein MSC PF09402.5 KOO27435.1 - 6.2 5.4 12.4 0.079 11.6 1.2 2.6 1 1 2 3 3 3 0 Man1-Src1p-C-terminal domain EF-hand_7 PF13499.1 KOO27436.1 - 4e-10 39.6 0.4 6.9e-10 38.9 0.3 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO27436.1 - 3e-09 35.4 0.2 0.00027 20.0 0.1 2.5 2 0 0 2 2 2 2 EF hand Na_Ca_ex PF01699.19 KOO27436.1 - 3.1e-09 36.5 22.4 2.8e-08 33.4 6.8 2.6 2 1 0 2 2 2 2 Sodium/calcium exchanger protein EF-hand_6 PF13405.1 KOO27436.1 - 2.8e-07 29.8 0.3 0.014 15.2 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO27436.1 - 0.00027 20.5 0.4 0.0006 19.3 0.2 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO27436.1 - 0.0094 15.2 0.2 2.3 7.6 0.1 2.6 2 0 0 2 2 2 2 EF hand Cpn60_TCP1 PF00118.19 KOO27438.1 - 4e-148 494.0 5.6 4.7e-148 493.8 3.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family MOSC PF03473.12 KOO27439.1 - 5e-09 35.7 0.2 8.7e-09 34.9 0.2 1.4 1 0 0 1 1 1 1 MOSC domain FAST_1 PF06743.10 KOO27440.1 - 3.7e-14 52.1 0.5 0.025 14.2 0.0 4.5 1 1 2 4 4 4 4 FAST kinase-like protein, subdomain 1 GrpE PF01025.14 KOO27441.1 - 1.4e-32 112.5 5.6 5.3e-32 110.6 3.8 1.8 1 1 0 1 1 1 1 GrpE DUF603 PF04645.7 KOO27441.1 - 0.017 15.0 0.3 0.024 14.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF603 OrfB_IS605 PF01385.14 KOO27441.1 - 0.03 13.7 0.4 0.044 13.1 0.2 1.2 1 0 0 1 1 1 0 Probable transposase Apolipoprotein PF01442.13 KOO27441.1 - 0.032 13.7 7.7 0.043 13.3 5.0 1.4 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF812 PF05667.6 KOO27441.1 - 0.033 12.6 6.3 0.043 12.3 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) CENP-F_leu_zip PF10473.4 KOO27441.1 - 0.04 13.7 7.1 0.06 13.2 4.9 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Apc4 PF12896.2 KOO27441.1 - 0.19 11.0 2.0 0.93 8.7 1.4 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 4 TPR_MLP1_2 PF07926.7 KOO27441.1 - 0.21 11.3 10.0 0.52 10.0 7.0 1.7 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein APG6 PF04111.7 KOO27441.1 - 0.45 9.5 8.5 0.62 9.0 5.9 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.9 KOO27441.1 - 0.73 9.3 5.0 0.99 8.9 3.5 1.3 1 0 0 1 1 1 0 IncA protein DUF972 PF06156.8 KOO27441.1 - 1 9.7 3.6 1.6 9.1 2.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF972) AAA_12 PF13087.1 KOO27442.1 - 1.2e-22 80.2 0.0 1.9e-22 79.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain RNase_H_2 PF13482.1 KOO27442.1 - 6.4e-19 68.3 0.0 1e-18 67.6 0.0 1.3 1 0 0 1 1 1 1 RNase_H superfamily AAA_11 PF13086.1 KOO27442.1 - 1.1e-13 51.3 0.1 5e-06 26.2 0.0 2.6 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.1 KOO27442.1 - 1.1e-12 47.9 1.5 1.3e-07 31.3 0.1 2.7 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 KOO27442.1 - 4e-12 45.6 2.3 4e-12 45.6 1.6 3.7 3 0 0 3 3 3 1 Part of AAA domain Helicase_RecD PF05127.9 KOO27442.1 - 4.1e-05 23.3 0.5 0.045 13.3 0.1 2.4 2 0 0 2 2 2 2 Helicase PDDEXK_1 PF12705.2 KOO27442.1 - 0.00039 19.8 0.0 0.00072 19.0 0.0 1.3 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily IstB_IS21 PF01695.12 KOO27442.1 - 0.0023 17.3 0.1 0.019 14.3 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein ArgK PF03308.11 KOO27442.1 - 0.0037 16.0 0.1 0.0064 15.2 0.1 1.3 1 0 0 1 1 1 1 ArgK protein AAA PF00004.24 KOO27442.1 - 0.005 17.0 0.0 0.11 12.6 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.4 KOO27442.1 - 0.013 14.4 0.0 0.031 13.2 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.1 KOO27442.1 - 0.03 14.4 0.0 0.87 9.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 KOO27442.1 - 0.033 13.9 0.0 0.069 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ResIII PF04851.10 KOO27442.1 - 0.033 14.0 0.0 0.079 12.7 0.0 1.5 2 0 0 2 2 1 0 Type III restriction enzyme, res subunit PIF1 PF05970.9 KOO27442.1 - 0.041 12.8 0.0 0.064 12.1 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase PhoH PF02562.11 KOO27442.1 - 0.21 10.8 0.1 0.37 9.9 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Med26 PF08711.6 KOO27443.1 - 6.3e-15 54.4 0.1 1.1e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 TFIIS helical bundle-like domain TRAM_LAG1_CLN8 PF03798.11 KOO27444.1 - 2.2e-16 59.9 6.8 3.5e-16 59.3 4.7 1.3 1 0 0 1 1 1 1 TLC domain PAN_4 PF14295.1 KOO27447.1 - 0.00053 19.6 1.1 0.00053 19.6 0.7 2.1 2 0 0 2 2 2 1 PAN domain Glyco_hydro_79n PF03662.9 KOO27447.1 - 0.0065 15.1 0.1 6 5.3 0.0 3.0 1 1 2 3 3 3 3 Glycosyl hydrolase family 79, N-terminal domain P2X_receptor PF00864.14 KOO27448.1 - 1.2e-06 27.4 4.4 0.00075 18.3 2.7 2.5 2 1 0 3 3 3 2 ATP P2X receptor FixP_N PF14715.1 KOO27448.1 - 1.2 8.6 4.0 2.3 7.6 2.8 1.5 1 0 0 1 1 1 0 N-terminal domain of cytochrome oxidase-cbb3, FixP TPT PF03151.11 KOO27449.1 - 8.2e-13 48.2 2.9 1.4e-12 47.4 2.0 1.4 1 0 0 1 1 1 1 Triose-phosphate Transporter family DUF2970 PF11174.3 KOO27449.1 - 9.1 5.9 7.9 0.34 10.5 1.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) Trs65 PF12735.2 KOO27451.1 - 1.5e-10 40.8 0.3 6.4e-08 32.2 0.0 2.0 2 0 0 2 2 2 2 TRAPP trafficking subunit Trs65 Transglut_C PF00927.17 KOO27451.1 - 0.0027 17.7 0.1 0.0053 16.7 0.0 1.5 1 1 0 1 1 1 1 Transglutaminase family, C-terminal ig like domain DUF974 PF06159.8 KOO27451.1 - 0.007 15.8 0.2 0.023 14.1 0.0 1.8 2 1 0 2 2 2 1 Protein of unknown function (DUF974) IlvB_leader PF08049.6 KOO27451.1 - 0.11 12.2 0.1 0.23 11.2 0.1 1.6 1 0 0 1 1 1 0 IlvB leader peptide DUF974 PF06159.8 KOO27452.1 - 6.2e-40 137.2 0.0 7.2e-40 137.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF974) CPSF100_C PF13299.1 KOO27453.1 - 6.7e-20 71.8 0.0 1.4e-17 64.3 0.0 2.3 1 1 1 2 2 2 2 Cleavage and polyadenylation factor 2 C-terminal RMMBL PF07521.7 KOO27453.1 - 0.00055 19.6 0.0 0.0011 18.7 0.0 1.5 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase Lactamase_B PF00753.22 KOO27454.1 - 5.8e-09 35.8 0.1 1.3e-08 34.7 0.0 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 KOO27454.1 - 4.4e-07 29.6 0.0 6.1e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Beta-Casp PF10996.3 KOO27454.1 - 8.1e-05 22.5 0.0 0.00013 21.8 0.0 1.4 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B_3 PF13483.1 KOO27454.1 - 0.001 18.7 0.0 0.0021 17.7 0.0 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Nucleotid_trans PF03407.11 KOO27455.1 - 1.1e-19 71.1 0.2 4.2e-19 69.1 0.1 1.8 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Sulfotransfer_2 PF03567.9 KOO27456.1 - 0.0014 18.3 0.0 0.0029 17.3 0.0 1.6 1 1 0 1 1 1 1 Sulfotransferase family Peptidase_M24 PF00557.19 KOO27457.1 - 1.3e-48 165.3 0.1 1.6e-48 165.0 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 WD40 PF00400.27 KOO27458.1 - 2.1e-20 71.7 14.7 9.3e-05 22.1 0.0 9.7 11 0 0 11 11 11 4 WD domain, G-beta repeat Reo_sigmaC PF04582.7 KOO27458.1 - 0.0039 16.4 1.1 0.033 13.3 0.1 2.6 2 1 2 4 4 4 2 Reovirus sigma C capsid protein TMF_DNA_bd PF12329.3 KOO27458.1 - 0.0094 15.7 6.6 0.0094 15.7 4.6 6.7 4 2 3 7 7 7 2 TATA element modulatory factor 1 DNA binding Nup160 PF11715.3 KOO27458.1 - 0.015 13.4 0.0 2.6 6.0 0.0 2.6 2 1 0 2 2 2 0 Nucleoporin Nup120/160 eIF2A PF08662.6 KOO27458.1 - 0.18 11.4 0.0 0.61 9.7 0.0 1.8 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A COG2 PF06148.6 KOO27458.1 - 5.6 6.8 26.2 0.024 14.4 0.6 4.2 3 1 1 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 NHL PF01436.16 KOO27460.1 - 2.3e-09 36.7 2.0 0.2 11.6 0.0 6.2 7 1 0 7 7 7 4 NHL repeat DUF2252 PF10009.4 KOO27461.1 - 4.3e-62 210.2 1.1 6e-62 209.7 0.8 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2252) Spore_GerAC PF05504.6 KOO27461.1 - 0.049 13.4 2.3 1.4 8.6 0.0 2.4 2 1 0 2 2 2 0 Spore germination B3/ GerAC like, C-terminal GRP PF07172.6 KOO27462.1 - 0.0023 18.3 3.6 0.0055 17.1 2.5 1.6 1 0 0 1 1 1 1 Glycine rich protein family RIB43A PF05914.7 KOO27462.1 - 8.8 4.8 10.8 1.4 7.5 0.5 2.1 2 0 0 2 2 2 0 RIB43A Chloroa_b-bind PF00504.16 KOO27463.1 - 5.7e-26 91.6 0.1 7.8e-26 91.1 0.0 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein LRR_6 PF13516.1 KOO27464.1 - 2.5e-07 30.0 0.7 1.1 9.5 0.0 4.6 4 0 0 4 4 4 4 Leucine Rich repeat LRR_4 PF12799.2 KOO27464.1 - 0.011 15.3 0.0 0.047 13.3 0.0 2.0 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) Sas10 PF09368.5 KOO27467.1 - 1.4e-24 86.0 6.3 1.4e-24 86.0 4.4 2.4 3 0 0 3 3 3 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.10 KOO27467.1 - 2.9e-19 69.0 0.8 6.4e-19 67.9 0.6 1.6 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Peptidase_M23 PF01551.17 KOO27468.1 - 3.5e-19 68.6 0.1 5.5e-19 68.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M23 Mg_trans_NIPA PF05653.9 KOO27469.1 - 6.1e-50 169.8 17.7 5.6e-49 166.7 12.3 2.2 1 1 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.15 KOO27469.1 - 3e-06 27.2 7.7 3e-06 27.2 5.3 3.3 4 1 0 4 4 4 1 EamA-like transporter family EmrE PF13536.1 KOO27469.1 - 6.2e-06 26.3 21.8 1.3e-05 25.3 5.7 3.2 3 1 0 3 3 3 2 Multidrug resistance efflux transporter GTP_EFTU PF00009.22 KOO27470.1 - 6.4e-52 175.7 0.0 7.9e-52 175.4 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.1 KOO27470.1 - 1.1e-21 76.4 0.0 2.1e-21 75.5 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.19 KOO27470.1 - 3.3e-21 74.9 0.0 6.1e-21 74.0 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.18 KOO27470.1 - 0.0033 17.3 0.0 0.0058 16.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.20 KOO27470.1 - 0.054 13.6 0.0 0.15 12.1 0.0 1.8 1 0 0 1 1 1 0 Elongation factor Tu domain 2 DUF3605 PF12239.3 KOO27472.1 - 0.0037 17.1 0.0 0.0061 16.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) Aa_trans PF01490.13 KOO27473.1 - 2.7e-58 197.4 21.9 3.1e-58 197.1 15.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 KOO27473.1 - 1.9e-14 53.3 17.1 1.9e-14 53.3 11.9 2.1 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family Anoctamin PF04547.7 KOO27475.1 - 9.4e-104 347.5 11.2 1.4e-103 346.9 7.8 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel cobW PF02492.14 KOO27475.1 - 3.9e-49 166.4 1.6 6.7e-49 165.7 1.1 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain SNF2_N PF00176.18 KOO27475.1 - 1.4e-48 165.2 1.1 1.7e-48 164.9 0.1 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOO27475.1 - 7e-14 51.4 0.2 3.1e-13 49.3 0.0 2.2 3 0 0 3 3 2 1 Helicase conserved C-terminal domain CobW_C PF07683.9 KOO27475.1 - 2.5e-12 46.3 0.0 9.5e-12 44.4 0.0 2.1 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain DEAD PF00270.24 KOO27475.1 - 7.2e-06 25.6 0.0 2.3e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 KOO27475.1 - 2.8e-05 24.2 0.1 0.31 11.1 0.0 3.5 4 0 0 4 4 4 2 AAA domain CbiA PF01656.18 KOO27475.1 - 0.00017 21.0 0.4 0.0039 16.6 0.2 2.5 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain HDA2-3 PF11496.3 KOO27475.1 - 0.0019 17.0 0.0 0.0043 15.9 0.0 1.5 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 SEC-C PF02810.10 KOO27475.1 - 0.003 17.0 5.2 0.0078 15.7 3.6 1.7 1 0 0 1 1 1 1 SEC-C motif GTP_EFTU PF00009.22 KOO27475.1 - 0.0099 15.3 2.4 0.075 12.4 1.7 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.1 KOO27475.1 - 0.011 15.7 0.1 0.41 10.5 0.0 3.1 2 0 0 2 2 2 0 AAA ATPase domain MMR_HSR1 PF01926.18 KOO27475.1 - 0.024 14.5 0.0 0.066 13.1 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_19 PF13245.1 KOO27475.1 - 0.027 14.2 0.9 0.12 12.0 0.2 2.3 2 0 0 2 2 2 0 Part of AAA domain Arch_ATPase PF01637.13 KOO27475.1 - 0.028 14.1 0.0 0.089 12.4 0.0 1.8 2 0 0 2 2 1 0 Archaeal ATPase AAA_14 PF13173.1 KOO27475.1 - 0.047 13.5 0.1 0.31 10.9 0.0 2.4 3 0 0 3 3 2 0 AAA domain AAA_18 PF13238.1 KOO27475.1 - 0.068 13.4 2.0 0.98 9.7 0.0 3.8 5 0 0 5 5 4 0 AAA domain MobB PF03205.9 KOO27475.1 - 0.1 12.3 0.2 0.82 9.3 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 KOO27475.1 - 0.12 11.8 0.0 0.55 9.6 0.0 2.1 2 0 0 2 2 2 0 AAA-like domain AAA_23 PF13476.1 KOO27475.1 - 0.71 10.1 0.0 0.71 10.1 0.0 2.9 3 1 0 3 3 3 0 AAA domain AAA_29 PF13555.1 KOO27475.1 - 1 8.9 3.7 0.44 10.1 0.1 2.2 2 0 0 2 2 1 0 P-loop containing region of AAA domain zf-C2HC_2 PF13913.1 KOO27476.1 - 4e-24 83.7 16.2 1.3e-09 37.4 0.8 3.4 3 0 0 3 3 3 3 zinc-finger of a C2HC-type SHOCT PF09851.4 KOO27476.1 - 3.3e-06 26.3 0.2 6.9e-06 25.3 0.1 1.6 1 0 0 1 1 1 1 Short C-terminal domain zf-C2H2_4 PF13894.1 KOO27476.1 - 7.9e-05 22.7 12.8 0.0039 17.4 0.8 3.7 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2 PF00096.21 KOO27476.1 - 0.00078 19.6 17.9 0.0012 19.0 0.8 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type DUF164 PF02591.10 KOO27476.1 - 0.0052 16.5 2.0 6.9 6.5 0.0 4.3 5 0 0 5 5 5 1 Putative zinc ribbon domain zf-RING_3 PF14369.1 KOO27476.1 - 0.0057 16.6 5.0 3.3 7.7 0.0 3.9 4 0 0 4 4 4 2 zinc-finger zf-ribbon_3 PF13248.1 KOO27476.1 - 0.034 13.3 4.7 9.1 5.6 0.4 3.4 3 0 0 3 3 3 0 zinc-ribbon domain zf-C2H2_6 PF13912.1 KOO27476.1 - 0.14 12.1 5.0 6.7 6.7 0.0 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-FPG_IleRS PF06827.9 KOO27476.1 - 0.18 11.4 4.6 2 8.1 0.1 2.7 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS FYVE PF01363.16 KOO27476.1 - 0.26 11.2 6.9 6.1 6.8 0.4 3.8 4 0 0 4 4 4 0 FYVE zinc finger zf-C2H2_jaz PF12171.3 KOO27476.1 - 0.28 11.3 11.1 2.5 8.3 0.0 4.0 4 1 1 5 5 4 0 Zinc-finger double-stranded RNA-binding Rad50_zn_hook PF04423.9 KOO27476.1 - 0.31 10.5 3.1 14 5.2 0.0 3.4 3 0 0 3 3 3 0 Rad50 zinc hook motif DUF2256 PF10013.4 KOO27476.1 - 3 7.6 6.8 28 4.5 0.0 3.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-Di19 PF05605.7 KOO27476.1 - 4 7.6 12.0 6.4 6.9 0.5 3.3 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_5 PF13719.1 KOO27476.1 - 9.8 5.8 7.5 19 4.9 0.0 3.7 4 0 0 4 4 4 0 zinc-ribbon domain FixQ PF05545.6 KOO27477.1 - 0.0021 17.6 1.5 0.0054 16.3 1.1 1.8 1 0 0 1 1 1 1 Cbb3-type cytochrome oxidase component FixQ UQ_con PF00179.21 KOO27478.1 - 3.2e-52 175.6 0.0 3.6e-52 175.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 KOO27478.1 - 0.0014 18.4 0.2 0.0028 17.5 0.1 1.6 1 1 0 1 1 1 1 RWD domain Prok-E2_B PF14461.1 KOO27478.1 - 0.0093 15.7 0.0 0.012 15.3 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B WD40_alt PF14077.1 KOO27479.1 - 1.3 8.6 7.6 15 5.2 0.1 3.9 3 0 0 3 3 3 0 Alternative WD40 repeat motif FlaC_arch PF05377.6 KOO27479.1 - 2.3 8.2 5.0 86 3.1 0.0 5.1 6 0 0 6 6 6 0 Flagella accessory protein C (FlaC) PPR_3 PF13812.1 KOO27480.1 - 0.001 19.1 8.7 0.31 11.4 0.0 6.4 7 0 0 7 7 7 1 Pentatricopeptide repeat domain DUF2103 PF09876.4 KOO27481.1 - 0.031 14.0 0.3 0.83 9.4 0.2 2.5 1 1 0 1 1 1 0 Predicted metal-binding protein (DUF2103) Not3 PF04065.10 KOO27481.1 - 0.049 12.9 0.0 0.049 12.9 0.0 3.0 3 0 0 3 3 3 0 Not1 N-terminal domain, CCR4-Not complex component PARP PF00644.15 KOO27482.1 - 2.8e-11 43.2 0.0 4.8e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Cation_efflux PF01545.16 KOO27483.1 - 1.6e-10 40.5 0.1 2.8e-10 39.7 0.1 1.4 1 1 0 1 1 1 1 Cation efflux family DUF4341 PF14241.1 KOO27484.1 - 7.8e-11 41.5 5.3 1.3e-10 40.8 2.9 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4341) zf-C3HC4_3 PF13920.1 KOO27484.1 - 4.1e-10 39.1 3.4 9.2e-10 38.0 2.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Sulf_transp PF04143.9 KOO27484.1 - 7.4e-10 38.6 6.5 7.4e-10 38.6 4.5 2.8 3 0 0 3 3 3 1 Sulphur transport zf-RING_5 PF14634.1 KOO27484.1 - 4.8e-09 35.8 3.5 9.2e-09 34.8 2.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 KOO27484.1 - 9.2e-09 34.8 3.4 1.8e-08 33.8 2.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO27484.1 - 1.3e-08 34.7 5.1 3.1e-08 33.4 3.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO27484.1 - 1.9e-08 34.0 4.9 3.6e-08 33.1 3.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.1 KOO27484.1 - 3.3e-06 26.7 1.4 6.6e-06 25.7 1.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger VWA_2 PF13519.1 KOO27484.1 - 7.4e-05 22.9 0.0 0.00023 21.3 0.0 1.8 1 1 0 1 1 1 1 von Willebrand factor type A domain zf-C3HC4_4 PF15227.1 KOO27484.1 - 0.00015 21.6 5.6 0.00033 20.4 3.9 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.1 KOO27484.1 - 0.00099 18.6 3.7 0.002 17.6 2.6 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.2 KOO27484.1 - 0.043 13.9 1.3 0.11 12.5 0.9 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger Rad50_zn_hook PF04423.9 KOO27484.1 - 1.9 8.0 4.1 0.27 10.7 0.1 1.7 2 0 0 2 2 1 0 Rad50 zinc hook motif Prok-RING_4 PF14447.1 KOO27484.1 - 6.1 6.4 11.2 12 5.4 3.2 2.9 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 Arm PF00514.18 KOO27486.1 - 5.2e-45 149.8 20.7 5.8e-08 32.2 0.1 8.2 8 0 0 8 8 8 7 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.4 KOO27486.1 - 1.1e-05 25.1 3.7 0.17 11.6 0.5 3.8 2 1 2 4 4 4 2 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.8 KOO27486.1 - 2e-05 23.8 2.2 0.00084 18.5 0.1 2.6 1 1 2 3 3 3 1 Armadillo-like TPR_11 PF13414.1 KOO27486.1 - 9.7e-05 21.9 1.5 0.55 9.9 0.1 4.5 4 0 0 4 4 4 2 TPR repeat TPR_17 PF13431.1 KOO27486.1 - 0.00011 22.1 0.0 4 7.8 0.0 4.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO27486.1 - 0.017 14.9 8.1 0.88 9.6 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat PX PF00787.19 KOO27486.1 - 0.04 13.7 0.2 0.085 12.6 0.1 1.5 1 0 0 1 1 1 0 PX domain Phosphoesterase PF04185.9 KOO27487.1 - 4e-52 177.6 0.0 5.2e-29 101.5 0.0 2.2 1 1 1 2 2 2 2 Phosphoesterase family Got1 PF04178.7 KOO27488.1 - 7.5e-27 93.7 14.5 9.8e-27 93.4 10.0 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family Ninjurin PF04923.7 KOO27488.1 - 0.033 13.8 1.4 0.042 13.5 0.1 1.7 2 0 0 2 2 2 0 Ninjurin Kinesin PF00225.18 KOO27489.1 - 0.0014 17.4 0.0 0.002 16.8 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain FHA PF00498.21 KOO27489.1 - 0.0028 17.7 0.0 0.0049 16.9 0.0 1.4 1 0 0 1 1 1 1 FHA domain HHH_3 PF12836.2 KOO27491.1 - 2.6e-11 43.2 0.0 4.3e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif S1 PF00575.18 KOO27491.1 - 4.7e-10 39.4 0.0 7.1e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 S1 RNA binding domain HHH PF00633.18 KOO27491.1 - 0.0077 15.8 0.0 0.026 14.2 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif T2SK PF03934.8 KOO27491.1 - 0.015 14.5 0.2 0.67 9.0 0.0 2.1 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein K HHH_8 PF14716.1 KOO27491.1 - 0.14 12.3 0.1 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix domain Ank_2 PF12796.2 KOO27492.1 - 4.5e-93 305.7 28.9 1.2e-17 64.0 0.1 7.8 2 2 7 9 9 9 9 Ankyrin repeats (3 copies) TPR_12 PF13424.1 KOO27492.1 - 3.1e-75 248.1 23.4 3.1e-19 68.7 0.1 5.5 1 1 5 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.1 KOO27492.1 - 8.4e-65 213.0 33.9 1.2e-12 47.3 0.4 7.7 7 0 0 7 7 6 6 Tetratricopeptide repeat Ank_4 PF13637.1 KOO27492.1 - 3.1e-50 167.7 2.1 4.6e-08 33.3 0.0 10.2 5 4 4 10 10 10 9 Ankyrin repeats (many copies) Ank PF00023.25 KOO27492.1 - 6.3e-49 161.4 17.4 1.5e-05 24.5 0.0 14.0 13 1 0 13 13 13 10 Ankyrin repeat Ank_5 PF13857.1 KOO27492.1 - 6.5e-35 118.3 15.8 5.9e-05 23.1 0.0 11.4 5 3 6 11 11 10 7 Ankyrin repeats (many copies) Tex_N PF09371.5 KOO27492.1 - 8.4e-35 119.8 0.0 1.9e-34 118.6 0.0 1.6 1 0 0 1 1 1 1 Tex-like protein N-terminal domain Ank_3 PF13606.1 KOO27492.1 - 8.9e-29 96.6 5.4 0.081 13.2 0.0 13.4 13 0 0 13 13 13 5 Ankyrin repeat TPR_1 PF00515.23 KOO27492.1 - 8.3e-21 72.6 2.3 0.0032 16.9 0.0 6.6 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.1 KOO27492.1 - 5.4e-14 51.5 3.0 0.0022 17.6 0.5 4.4 2 1 2 4 4 4 4 TPR repeat TPR_2 PF07719.12 KOO27492.1 - 1.7e-13 49.3 5.0 0.087 12.7 0.1 7.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO27492.1 - 8.7e-12 43.9 12.0 0.096 12.5 0.1 7.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO27492.1 - 1.4e-11 43.5 0.6 1.8 8.9 0.0 7.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO27492.1 - 3.6e-11 43.4 23.3 0.00053 20.5 0.1 6.7 4 2 2 6 6 4 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO27492.1 - 6.3e-09 34.9 0.9 0.34 10.7 0.0 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat PARP PF00644.15 KOO27492.1 - 2.3e-07 30.4 0.0 4.5e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain TPR_4 PF07721.9 KOO27492.1 - 0.00045 20.3 42.1 0.37 11.3 0.0 10.4 11 0 0 11 11 7 2 Tetratricopeptide repeat Osmo_CC PF08946.5 KOO27492.1 - 0.0058 16.6 8.7 44 4.2 0.0 6.7 7 0 0 7 7 6 0 Osmosensory transporter coiled coil TPR_3 PF07720.7 KOO27492.1 - 0.0076 16.0 0.0 99 2.8 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF460 PF04312.8 KOO27492.1 - 0.014 14.9 0.1 0.041 13.4 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF460) YqgF PF14639.1 KOO27492.1 - 0.12 11.9 0.0 0.26 10.8 0.0 1.6 1 0 0 1 1 1 0 Holliday-junction resolvase-like of SPT6 Thioredoxin PF00085.15 KOO27493.1 - 1.3e-27 95.4 0.2 1.4e-26 92.2 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.1 KOO27493.1 - 4.2e-05 23.7 1.7 0.00014 22.0 0.1 2.5 2 2 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_7 PF13899.1 KOO27493.1 - 0.0036 17.3 0.0 0.0084 16.1 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_6 PF13848.1 KOO27493.1 - 0.0054 16.5 0.0 0.73 9.6 0.0 2.3 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 KOO27493.1 - 0.01 15.9 0.0 0.034 14.2 0.0 1.8 1 1 0 1 1 1 0 Thioredoxin-like TMF_DNA_bd PF12329.3 KOO27493.1 - 0.019 14.7 4.1 0.038 13.7 2.8 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding AhpC-TSA PF00578.16 KOO27493.1 - 0.058 13.0 0.0 0.16 11.6 0.0 1.7 1 0 0 1 1 1 0 AhpC/TSA family DUF4456 PF14644.1 KOO27493.1 - 0.063 12.4 1.4 3 7.0 0.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4456) SASP PF00269.15 KOO27493.1 - 0.078 12.8 0.6 0.4 10.5 0.3 2.1 2 0 0 2 2 2 0 Small, acid-soluble spore proteins, alpha/beta type Redoxin PF08534.5 KOO27493.1 - 0.1 12.1 0.3 0.25 10.8 0.0 1.7 2 1 0 2 2 2 0 Redoxin FAD_binding_3 PF01494.14 KOO27494.1 - 9.1e-18 64.4 0.4 3.9e-11 42.6 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.1 KOO27494.1 - 3.1e-06 27.0 1.2 7.8e-06 25.8 0.8 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOO27494.1 - 6.3e-06 25.3 9.0 0.0014 17.5 0.7 3.1 2 1 1 3 3 3 2 FAD dependent oxidoreductase Pyr_redox PF00070.22 KOO27494.1 - 0.0055 17.0 1.2 5 7.5 0.5 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 KOO27494.1 - 0.012 15.3 1.8 0.012 15.3 1.2 2.8 2 1 0 2 2 2 0 FAD-NAD(P)-binding Trp_halogenase PF04820.9 KOO27494.1 - 0.02 13.5 0.1 0.44 9.1 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase FAD_binding_2 PF00890.19 KOO27494.1 - 0.06 12.1 2.9 0.096 11.5 2.0 1.5 1 1 0 1 1 1 0 FAD binding domain SE PF08491.5 KOO27494.1 - 0.092 11.5 0.0 0.18 10.6 0.0 1.4 1 0 0 1 1 1 0 Squalene epoxidase Methyltransf_21 PF05050.7 KOO27495.1 - 2.5e-06 27.5 0.0 4.8e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase FkbM domain SRR1 PF07985.7 KOO27498.1 - 2.9e-09 36.7 0.4 3.1e-07 30.2 0.1 2.5 2 0 0 2 2 2 2 SRR1 NAD_binding_1 PF00175.16 KOO27500.1 - 3e-18 66.3 0.0 1.3e-16 61.1 0.0 2.1 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 KOO27500.1 - 3.8e-11 42.9 0.0 8.7e-11 41.8 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 KOO27500.1 - 5.3e-05 23.1 0.0 0.0058 16.5 0.0 2.1 2 0 0 2 2 2 2 Ferric reductase NAD binding domain Complex1_30kDa PF00329.14 KOO27501.1 - 3.1e-34 117.2 0.0 4.5e-34 116.7 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit CLP_protease PF00574.18 KOO27502.1 - 3.9e-79 264.5 0.0 4.7e-79 264.2 0.0 1.0 1 0 0 1 1 1 1 Clp protease CorA PF01544.13 KOO27503.1 - 0.073 12.0 1.1 0.11 11.4 0.1 1.8 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Glucosamine_iso PF01182.15 KOO27504.1 - 5.1e-31 107.9 0.0 6.7e-31 107.5 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Aft1_HRA PF11786.3 KOO27504.1 - 0.096 12.9 0.2 0.24 11.6 0.1 1.7 1 0 0 1 1 1 0 Aft1 HRA domain Hydrolase_6 PF13344.1 KOO27505.1 - 4.5e-10 39.3 0.0 1.6e-09 37.5 0.0 1.8 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Dak1 PF02733.12 KOO27506.1 - 2.3e-113 378.0 2.2 4.3e-113 377.1 1.5 1.3 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.12 KOO27506.1 - 7.1e-43 146.2 15.7 7.1e-43 146.2 10.9 2.4 3 0 0 3 3 3 1 DAK2 domain Nol1_Nop2_Fmu PF01189.12 KOO27507.1 - 1.5e-41 142.6 0.0 2e-41 142.2 0.0 1.1 1 0 0 1 1 1 1 NOL1/NOP2/sun family Methyltransf_26 PF13659.1 KOO27507.1 - 4.5e-09 36.3 0.5 4.5e-09 36.3 0.3 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO27507.1 - 1.1e-07 31.5 0.0 1.8e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO27507.1 - 3.6e-07 30.7 0.1 2.2e-06 28.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 KOO27507.1 - 4.6e-05 22.8 0.0 8.9e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_3 PF01596.12 KOO27507.1 - 0.00015 20.9 0.0 0.00031 19.8 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase Ubie_methyltran PF01209.13 KOO27507.1 - 0.00017 20.8 0.0 0.0013 17.8 0.0 1.9 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.14 KOO27507.1 - 0.032 14.2 0.0 0.061 13.3 0.0 1.4 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_11 PF08241.7 KOO27507.1 - 0.04 14.4 0.0 17 5.9 0.0 2.7 3 0 0 3 3 3 0 Methyltransferase domain EF-hand_1 PF00036.27 KOO27508.1 - 4.4e-19 66.2 20.3 6e-05 22.0 0.1 7.0 7 0 0 7 7 7 6 EF hand EF-hand_7 PF13499.1 KOO27508.1 - 2.8e-16 59.3 15.9 0.0061 16.6 0.0 6.3 5 2 0 5 5 5 5 EF-hand domain pair EF-hand_6 PF13405.1 KOO27508.1 - 6.5e-14 50.5 22.1 0.0011 18.6 0.1 7.7 8 0 0 8 8 8 5 EF-hand domain EF-hand_5 PF13202.1 KOO27508.1 - 4.9e-10 38.2 10.2 0.0026 17.0 0.0 5.3 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.1 KOO27508.1 - 4.1e-08 32.6 11.2 5.2e-07 29.1 0.1 4.5 4 2 1 5 5 5 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO27508.1 - 0.075 13.0 5.8 0.78 9.7 0.3 3.5 4 1 0 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region ELFV_dehydrog_N PF02812.13 KOO27509.1 - 0.0059 16.1 0.1 0.13 11.8 0.0 2.6 3 0 0 3 3 3 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Cpn60_TCP1 PF00118.19 KOO27510.1 - 9.1e-95 318.0 6.9 1.2e-63 215.4 2.2 2.0 1 1 1 2 2 2 2 TCP-1/cpn60 chaperonin family Kinesin PF00225.18 KOO27512.1 - 1.1e-62 211.6 0.0 2.4e-62 210.5 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain CUE PF02845.11 KOO27512.1 - 0.0093 15.4 0.0 0.022 14.2 0.0 1.6 1 0 0 1 1 1 1 CUE domain SPX PF03105.14 KOO27512.1 - 0.014 15.2 4.2 0.025 14.3 2.9 1.3 1 0 0 1 1 1 0 SPX domain PLRV_ORF5 PF01690.12 KOO27512.1 - 3.7 6.5 12.1 5.9 5.9 8.4 1.4 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein JmjC PF02373.17 KOO27513.1 - 3.1e-33 114.3 0.1 5.6e-33 113.5 0.1 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.12 KOO27513.1 - 4.8e-13 48.3 0.1 8.8e-13 47.5 0.1 1.5 1 0 0 1 1 1 1 jmjN domain PHD PF00628.24 KOO27513.1 - 1.2e-11 44.1 7.9 2.2e-11 43.2 5.4 1.5 1 0 0 1 1 1 1 PHD-finger ARID PF01388.16 KOO27513.1 - 1.2e-07 31.5 0.0 2.3e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Prok-RING_1 PF14446.1 KOO27513.1 - 0.031 13.9 2.1 0.078 12.7 1.5 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 PHD_2 PF13831.1 KOO27513.1 - 0.15 11.4 2.9 0.38 10.1 2.0 1.7 1 0 0 1 1 1 0 PHD-finger zf-RING_2 PF13639.1 KOO27513.1 - 4.9 7.0 9.8 94 2.9 0.1 2.7 1 1 1 2 2 2 0 Ring finger domain Costars PF14705.1 KOO27515.1 - 2.2e-06 27.5 0.1 2.6e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Costars Diphthamide_syn PF01866.12 KOO27515.1 - 0.11 11.6 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Putative diphthamide synthesis protein PLU-1 PF08429.6 KOO27516.1 - 0.029 13.2 0.1 0.2 10.4 0.1 1.8 1 1 0 1 1 1 0 PLU-1-like protein RhoGEF PF00621.15 KOO27517.1 - 4e-38 131.0 0.0 4.8e-38 130.8 0.0 1.1 1 0 0 1 1 1 1 RhoGEF domain IL6 PF00489.12 KOO27517.1 - 0.042 13.4 0.1 0.071 12.6 0.0 1.3 1 0 0 1 1 1 0 Interleukin-6/G-CSF/MGF family Kinesin PF00225.18 KOO27518.1 - 1.6e-97 326.2 0.0 2.2e-97 325.7 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain TBPIP PF07106.8 KOO27518.1 - 0.31 10.5 10.3 0.12 11.9 1.6 3.0 3 0 0 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF972 PF06156.8 KOO27518.1 - 0.99 9.7 7.4 0.47 10.8 0.9 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF972) KIAA1430 PF13879.1 KOO27520.1 - 0.00035 20.9 6.8 0.00035 20.9 4.7 3.6 3 1 0 3 3 3 1 KIAA1430 homologue RNA_pol_Rpb1_5 PF04998.12 KOO27520.1 - 6.3 5.9 8.5 1.2e+02 1.7 5.9 2.4 1 1 0 1 1 1 0 RNA polymerase Rpb1, domain 5 Nol1_Nop2_Fmu PF01189.12 KOO27521.1 - 1.6e-14 53.9 0.0 1.9e-14 53.7 0.0 1.1 1 0 0 1 1 1 1 NOL1/NOP2/sun family Methyltransf_26 PF13659.1 KOO27521.1 - 0.043 13.8 0.4 0.12 12.3 0.0 1.9 2 1 0 2 2 2 0 Methyltransferase domain GST_N PF02798.15 KOO27524.1 - 3.3e-13 49.6 0.0 6.6e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 KOO27524.1 - 1.2e-12 47.5 0.1 2.3e-12 46.7 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 KOO27524.1 - 5.8e-08 32.6 0.0 1.1e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 KOO27524.1 - 6.4e-08 32.7 0.0 1.2e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KOO27524.1 - 6.5e-07 29.1 0.1 1e-06 28.4 0.1 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 KOO27524.1 - 0.00034 21.0 0.1 0.00051 20.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain VPEP PF07589.6 KOO27524.1 - 3.4 7.6 6.2 8 6.5 4.3 1.6 1 0 0 1 1 1 0 PEP-CTERM motif polyprenyl_synt PF00348.12 KOO27525.1 - 1.5e-59 200.9 2.4 1.7e-59 200.7 1.7 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase SQS_PSY PF00494.14 KOO27525.1 - 0.00044 19.6 4.3 0.00076 18.8 2.9 1.4 1 1 0 1 1 1 1 Squalene/phytoene synthase WHG PF13305.1 KOO27527.1 - 0.27 11.8 0.2 0.27 11.8 0.1 3.0 2 1 1 3 3 3 0 WHG domain AAA_13 PF13166.1 KOO27527.1 - 5.7 5.2 7.8 0.85 7.9 1.8 1.9 2 0 0 2 2 2 0 AAA domain SRP72 PF08492.7 KOO27528.1 - 2.3e-13 50.2 5.1 5.2e-13 49.1 3.5 1.6 1 0 0 1 1 1 1 SRP72 RNA-binding domain TPR_14 PF13428.1 KOO27528.1 - 1.5e-10 40.7 41.2 0.042 14.4 0.0 8.5 6 1 2 8 8 8 5 Tetratricopeptide repeat TPR_16 PF13432.1 KOO27528.1 - 2.3e-08 34.4 49.4 7.7e-05 23.2 0.1 8.0 6 3 2 9 9 8 3 Tetratricopeptide repeat Apc3 PF12895.2 KOO27528.1 - 2.7e-08 33.8 15.3 0.33 11.1 0.0 5.6 4 1 2 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 KOO27528.1 - 9.4e-06 25.0 11.1 1.6 8.7 0.1 6.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO27528.1 - 4.5e-05 23.0 31.4 0.091 12.7 0.4 8.3 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO27528.1 - 0.00026 20.5 27.2 0.19 11.3 3.0 6.2 5 2 0 5 5 5 3 TPR repeat TPR_19 PF14559.1 KOO27528.1 - 0.0081 16.4 0.2 0.0081 16.4 0.2 7.0 5 2 2 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO27528.1 - 0.11 12.3 8.3 0.46 10.3 0.0 5.1 8 0 0 8 8 8 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO27528.1 - 0.22 11.4 4.0 4.1 7.3 0.0 4.0 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.1 KOO27528.1 - 0.64 10.0 34.1 0.49 10.3 0.6 6.8 8 1 1 9 9 8 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO27528.1 - 4.1 7.3 29.9 22 4.9 0.3 7.2 5 2 2 7 7 7 0 Tetratricopeptide repeat AP2 PF00847.15 KOO27529.1 - 0.012 15.7 4.1 0.023 14.8 0.0 2.8 3 0 0 3 3 3 0 AP2 domain IF3_N PF05198.11 KOO27529.1 - 0.11 12.4 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 Translation initiation factor IF-3, N-terminal domain FAD_binding_4 PF01565.18 KOO27531.1 - 1.1e-23 83.2 0.5 1.8e-23 82.5 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain ALO PF04030.9 KOO27531.1 - 6.5e-15 55.4 0.0 3.5e-14 53.0 0.0 1.9 1 1 0 1 1 1 1 D-arabinono-1,4-lactone oxidase DUF2462 PF09495.5 KOO27532.1 - 5.9e-07 30.1 7.1 8.8e-07 29.5 4.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2462) Rad50_zn_hook PF04423.9 KOO27532.1 - 1.2 8.6 5.7 4.2 6.9 1.1 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-CCCH PF00642.19 KOO27533.1 - 5.7e-07 29.0 1.2 1.2e-06 28.0 0.8 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) GCV_H PF01597.14 KOO27533.1 - 0.012 15.2 0.0 0.029 14.0 0.0 1.7 2 0 0 2 2 2 0 Glycine cleavage H-protein zf-CCCH_2 PF14608.1 KOO27533.1 - 0.043 13.8 0.9 0.094 12.7 0.6 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type Longin PF13774.1 KOO27534.1 - 8.2e-27 92.5 0.0 1.2e-26 92.0 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.16 KOO27534.1 - 9.5e-18 63.5 0.0 1.6e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 Synaptobrevin Bacteroid_pep PF14406.1 KOO27534.1 - 0.061 13.4 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Ribosomally synthesized peptide in Bacteroidetes BBS2_C PF14782.1 KOO27534.1 - 0.11 11.0 0.7 0.17 10.4 0.3 1.4 1 1 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal PhoD PF09423.5 KOO27535.1 - 1.8e-14 53.1 0.0 6e-14 51.4 0.0 1.8 1 1 0 1 1 1 1 PhoD-like phosphatase Pkinase PF00069.20 KOO27536.1 - 4.7e-29 101.3 0.0 5.7e-29 101.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27536.1 - 2.1e-17 63.0 0.0 2.6e-17 62.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO27536.1 - 0.00055 19.0 0.0 0.00075 18.6 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 KOO27536.1 - 0.0021 17.0 0.0 0.0026 16.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 KOO27536.1 - 0.0099 14.7 0.1 0.012 14.4 0.1 1.1 1 0 0 1 1 1 1 Seadornavirus VP7 MFS_1 PF07690.11 KOO27537.1 - 3 6.4 31.4 0.005 15.6 9.7 2.7 1 1 1 2 2 2 0 Major Facilitator Superfamily EF-hand_1 PF00036.27 KOO27538.1 - 5.5e-15 53.4 1.0 0.0011 18.0 0.0 3.7 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.1 KOO27538.1 - 8.9e-14 51.3 0.8 4.4e-08 33.1 0.5 2.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO27538.1 - 4.4e-13 47.9 2.7 0.0013 18.4 0.0 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.1 KOO27538.1 - 4.8e-13 48.5 0.1 0.0017 17.9 0.0 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO27538.1 - 7e-09 34.6 0.8 0.00051 19.2 0.0 3.6 3 0 0 3 3 3 2 EF hand EF-hand_10 PF14788.1 KOO27538.1 - 0.028 14.0 0.0 5.3 6.7 0.0 2.8 3 0 0 3 3 3 0 EF hand Fapy_DNA_glyco PF01149.19 KOO27539.1 - 2.4e-25 89.1 0.0 4.3e-25 88.3 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.9 KOO27539.1 - 7e-20 70.5 0.0 1.2e-19 69.8 0.0 1.3 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain FbpA PF05833.6 KOO27539.1 - 0.01 14.3 0.0 0.018 13.6 0.0 1.3 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) CBM_6 PF03422.10 KOO27540.1 - 0.0071 16.4 0.3 0.019 15.1 0.2 1.7 1 0 0 1 1 1 1 Carbohydrate binding module (family 6) PPC PF04151.10 KOO27540.1 - 0.046 14.6 3.8 5 8.1 0.0 2.9 2 1 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain DEAD PF00270.24 KOO27541.1 - 1.1e-16 60.7 0.0 1.3e-16 60.5 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 KOO27541.1 - 6.7e-05 22.8 0.0 0.00011 22.0 0.0 1.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.1 KOO27541.1 - 0.058 12.9 0.0 0.095 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF512 PF04459.7 KOO27541.1 - 0.063 12.3 0.0 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF512) Pkinase PF00069.20 KOO27543.1 - 4.9e-62 209.4 0.0 6.3e-62 209.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27543.1 - 2.2e-40 138.4 0.0 3.1e-40 137.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Thioredoxin PF00085.15 KOO27543.1 - 1.5e-25 88.8 0.1 2.3e-25 88.2 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.1 KOO27543.1 - 4.3e-06 26.6 0.2 1.1e-05 25.3 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin-like APH PF01636.18 KOO27543.1 - 3.3e-05 23.7 7.1 0.00075 19.3 1.0 2.9 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO27543.1 - 7.1e-05 21.8 0.1 0.00021 20.3 0.1 1.7 1 1 0 1 1 1 1 Kinase-like Thioredoxin_8 PF13905.1 KOO27543.1 - 0.00068 19.6 0.0 0.0014 18.6 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Kdo PF06293.9 KOO27543.1 - 0.00086 18.4 0.6 0.0015 17.6 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Thioredoxin_2 PF13098.1 KOO27543.1 - 0.0084 16.3 0.1 0.054 13.6 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.1 KOO27543.1 - 0.034 13.6 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin AhpC-TSA PF00578.16 KOO27543.1 - 0.12 12.0 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family FA_hydroxylase PF04116.8 KOO27544.1 - 2.1e-10 40.9 19.0 2.1e-10 40.9 13.2 2.2 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily DUF2145 PF09916.4 KOO27544.1 - 0.028 13.9 0.0 0.06 12.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2145) Cap_synth_GfcB PF11102.3 KOO27544.1 - 0.17 11.4 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 Group 4 capsule polysaccharide formation lipoprotein gfcB Myosin_head PF00063.16 KOO27546.1 - 3.3e-138 461.7 0.0 2.5e-82 277.0 0.0 2.6 2 1 0 2 2 2 2 Myosin head (motor domain) AAA_22 PF13401.1 KOO27546.1 - 0.002 18.2 0.2 0.15 12.1 0.0 3.1 3 0 0 3 3 3 1 AAA domain EF-hand_1 PF00036.27 KOO27546.1 - 0.0057 15.8 0.0 3.4 7.1 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO27546.1 - 0.014 15.5 0.0 0.049 13.7 0.0 2.0 1 1 0 1 1 1 0 EF-hand domain pair AAA_16 PF13191.1 KOO27546.1 - 0.025 14.5 2.0 0.1 12.5 0.0 3.0 3 1 0 3 3 3 0 AAA ATPase domain EF-hand_6 PF13405.1 KOO27546.1 - 0.037 13.9 0.0 5.9 7.0 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain PAS PF00989.19 KOO27547.1 - 2.8e-12 46.4 0.0 8.5e-12 44.8 0.0 1.9 1 1 0 1 1 1 1 PAS fold PAS_4 PF08448.5 KOO27547.1 - 2.1e-06 27.7 0.4 1.2e-05 25.2 0.0 2.3 2 1 1 3 3 3 1 PAS fold PAS_9 PF13426.1 KOO27547.1 - 2.2e-06 28.0 0.0 4.5e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS_8 PF13188.1 KOO27547.1 - 0.0018 18.0 0.0 0.0064 16.3 0.0 1.9 2 0 0 2 2 2 1 PAS domain SlyX PF04102.7 KOO27547.1 - 0.24 11.7 0.3 0.24 11.7 0.2 2.4 3 0 0 3 3 3 0 SlyX DUF3185 PF11381.3 KOO27548.1 - 0.36 10.6 6.1 0.16 11.7 0.2 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3185) PGG PF13962.1 KOO27549.1 - 0.19 11.3 7.9 0.11 12.0 2.6 2.2 1 1 1 2 2 2 0 Domain of unknown function Orai-1 PF07856.7 KOO27549.1 - 7.1 6.1 10.7 1.7 8.2 4.2 2.4 2 1 0 2 2 2 0 Mediator of CRAC channel activity NifU_N PF01592.11 KOO27550.1 - 1.4e-49 167.2 0.0 1.6e-49 167.0 0.0 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain DUF4231 PF14015.1 KOO27551.1 - 2.1e-09 37.3 7.1 1.4e-08 34.6 0.1 2.8 3 0 0 3 3 3 2 Protein of unknown function (DUF4231) IQ PF00612.22 KOO27552.1 - 3.5e-07 29.2 0.4 0.016 14.7 0.1 2.6 2 0 0 2 2 2 2 IQ calmodulin-binding motif MatE PF01554.13 KOO27554.1 - 2.4e-22 79.2 16.3 8.7e-14 51.4 1.0 3.9 4 0 0 4 4 4 2 MatE Mid2 PF04478.7 KOO27554.1 - 0.0012 18.2 0.2 0.0024 17.2 0.2 1.4 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor Abhydrolase_1 PF00561.15 KOO27554.1 - 0.0087 15.6 0.1 7.2 6.0 0.0 3.0 3 0 0 3 3 3 2 alpha/beta hydrolase fold Ser_hydrolase PF06821.8 KOO27554.1 - 1.5 8.4 6.2 50 3.4 1.2 3.5 3 0 0 3 3 3 0 Serine hydrolase Ank_2 PF12796.2 KOO27555.1 - 4.8e-08 33.2 1.1 0.00018 21.7 0.1 1.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO27555.1 - 1.5e-06 28.2 4.0 3.2e-05 24.0 0.8 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO27555.1 - 7.9e-06 26.2 1.3 0.022 15.2 0.4 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO27555.1 - 8.1e-06 25.5 1.3 0.011 15.8 0.0 3.8 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.25 KOO27555.1 - 0.00011 21.8 3.1 0.073 12.9 0.1 3.6 3 0 0 3 3 3 1 Ankyrin repeat Skp1 PF01466.14 KOO27555.1 - 0.0027 17.7 0.0 0.0062 16.5 0.0 1.5 1 0 0 1 1 1 1 Skp1 family, dimerisation domain KIAA1430 PF13879.1 KOO27556.1 - 0.022 15.1 1.4 0.022 15.1 1.0 4.9 2 2 2 5 5 5 0 KIAA1430 homologue adh_short PF00106.20 KOO27557.1 - 0.034 14.0 0.7 0.11 12.3 0.4 1.9 2 0 0 2 2 2 0 short chain dehydrogenase DUF2180 PF09947.4 KOO27557.1 - 0.12 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2180) Cons_hypoth95 PF03602.10 KOO27559.1 - 0.11 11.8 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 zf-CCHC_2 PF13696.1 KOO27559.1 - 0.11 12.0 0.2 0.22 11.0 0.1 1.5 1 0 0 1 1 1 0 Zinc knuckle PALP PF00291.20 KOO27560.1 - 8.7e-59 199.2 0.1 1.6e-58 198.3 0.0 1.5 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.23 KOO27560.1 - 4.4e-09 36.0 0.2 1.3e-08 34.5 0.2 1.8 1 0 0 1 1 1 1 CBS domain GST_N_2 PF13409.1 KOO27562.1 - 1.3e-10 41.0 0.0 2.2e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 KOO27562.1 - 1.7e-09 37.7 0.0 3.5e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KOO27562.1 - 0.00036 20.3 0.2 0.0007 19.4 0.2 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 KOO27562.1 - 0.0034 17.5 0.0 0.007 16.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Pkinase PF00069.20 KOO27563.1 - 5.2e-41 140.5 0.0 7.5e-41 139.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27563.1 - 4.5e-17 61.9 0.0 6.5e-17 61.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase cNMP_binding PF00027.24 KOO27564.1 - 1.3e-11 44.1 0.1 0.00031 20.4 0.0 3.9 3 1 0 3 3 3 2 Cyclic nucleotide-binding domain EF-hand_7 PF13499.1 KOO27565.1 - 1e-09 38.3 0.6 2.4e-09 37.2 0.4 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO27565.1 - 2.1e-07 29.7 0.1 0.00091 18.3 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO27565.1 - 8.1e-07 28.4 0.5 0.0036 17.0 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO27565.1 - 2.8e-06 26.8 2.0 0.026 14.1 0.1 3.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_10 PF14788.1 KOO27565.1 - 0.00025 20.6 1.4 0.0044 16.6 0.1 2.4 1 1 1 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO27565.1 - 0.062 12.6 0.1 0.062 12.6 0.0 2.1 2 0 0 2 2 2 0 EF hand Lipase_3 PF01764.20 KOO27566.1 - 4.1e-34 117.1 0.0 5.5e-34 116.7 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.2 KOO27566.1 - 0.00069 19.5 0.3 0.00079 19.3 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO27566.1 - 0.0036 17.0 0.0 0.0042 16.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.3 KOO27566.1 - 0.056 12.8 0.1 0.27 10.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) SHIPPO-rpt PF07004.7 KOO27567.1 - 4.7e-08 33.5 12.0 0.099 13.5 0.0 5.4 5 0 0 5 5 5 4 Sperm-tail PG-rich repeat CASP_C PF08172.7 KOO27568.1 - 5.5e-33 114.0 1.8 5.5e-33 114.0 1.3 3.8 2 2 1 3 3 3 1 CASP C terminal GAS PF13851.1 KOO27568.1 - 0.0012 18.0 1.1 0.0012 18.0 0.8 4.2 2 1 3 5 5 5 1 Growth-arrest specific micro-tubule binding Phage_GP20 PF06810.6 KOO27568.1 - 0.014 14.8 0.5 0.014 14.8 0.4 3.3 2 1 1 3 3 3 0 Phage minor structural protein GP20 DUF3857 PF12969.2 KOO27568.1 - 0.1 12.1 2.7 2.7 7.5 0.2 2.5 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3857) Flagellin_C PF00700.16 KOO27568.1 - 0.11 12.6 8.3 2.5 8.3 0.8 3.5 3 0 0 3 3 3 0 Bacterial flagellin C-terminal helical region AAA_27 PF13514.1 KOO27568.1 - 0.95 7.0 60.8 1.3 6.5 42.1 1.1 1 0 0 1 1 1 0 AAA domain BLOC1_2 PF10046.4 KOO27568.1 - 2.8 8.1 10.8 3.4 7.8 0.2 3.6 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.7 KOO27568.1 - 3.2 7.5 5.5 2.8 7.7 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) AAA_13 PF13166.1 KOO27568.1 - 4.3 5.6 21.1 17 3.6 0.1 2.2 1 1 1 2 2 2 0 AAA domain Fer2 PF00111.22 KOO27569.1 - 6.9e-07 28.9 1.5 1.2e-06 28.2 1.0 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2_3 PF13085.1 KOO27569.1 - 0.0033 17.2 0.9 0.0043 16.8 0.6 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2_4 PF13510.1 KOO27569.1 - 0.059 13.1 3.1 0.067 13.0 0.8 2.1 2 1 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain KH_1 PF00013.24 KOO27569.1 - 0.1 12.2 0.2 0.17 11.5 0.1 1.3 1 0 0 1 1 1 0 KH domain FIST PF08495.5 KOO27569.1 - 0.12 11.5 0.1 0.18 10.8 0.1 1.2 1 0 0 1 1 1 0 FIST N domain Thiolase_C PF02803.13 KOO27570.1 - 0.085 12.2 0.1 0.15 11.4 0.1 1.4 1 0 0 1 1 1 0 Thiolase, C-terminal domain TMF_DNA_bd PF12329.3 KOO27571.1 - 0.0009 19.0 8.1 0.0009 19.0 5.6 6.2 4 2 2 6 6 6 2 TATA element modulatory factor 1 DNA binding Reo_sigmaC PF04582.7 KOO27571.1 - 0.3 10.2 13.5 0.04 13.1 2.9 2.9 1 1 1 2 2 2 0 Reovirus sigma C capsid protein FlaC_arch PF05377.6 KOO27571.1 - 0.44 10.4 13.1 6.5 6.7 0.1 4.8 5 0 0 5 5 5 0 Flagella accessory protein C (FlaC) Nudc_N PF14050.1 KOO27572.1 - 3.5e-21 74.9 0.1 5.4e-21 74.3 0.0 1.3 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. CS PF04969.11 KOO27572.1 - 1.8e-09 37.9 0.0 7.9e-09 35.9 0.0 1.9 1 1 0 1 1 1 1 CS domain Med3 PF11593.3 KOO27572.1 - 0.0025 17.0 9.7 0.0034 16.6 6.7 1.1 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal FAP PF07174.6 KOO27572.1 - 0.0044 16.3 22.1 0.0069 15.7 15.3 1.3 1 0 0 1 1 1 1 Fibronectin-attachment protein (FAP) Pol_alpha_B_N PF08418.5 KOO27572.1 - 0.052 13.0 1.6 0.072 12.6 1.1 1.1 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Totivirus_coat PF05518.6 KOO27572.1 - 8.6 4.0 16.5 13 3.4 11.4 1.2 1 0 0 1 1 1 0 Totivirus coat protein PKD_channel PF08016.7 KOO27574.1 - 8.5e-27 93.6 16.0 2.7e-24 85.3 12.3 2.2 2 0 0 2 2 2 2 Polycystin cation channel AP_endonuc_2 PF01261.19 KOO27575.1 - 0.00057 19.2 0.4 0.0012 18.1 0.3 1.6 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel SART-1 PF03343.8 KOO27575.1 - 0.22 9.8 0.0 0.36 9.1 0.0 1.2 1 0 0 1 1 1 0 SART-1 family Filamin PF00630.14 KOO27578.1 - 2.3e-59 198.2 0.0 1.5e-13 51.1 0.0 6.7 6 1 0 6 6 6 6 Filamin/ABP280 repeat Big_1 PF02369.11 KOO27578.1 - 1.1e-09 38.1 5.0 0.066 13.1 0.0 4.5 5 0 0 5 5 5 3 Bacterial Ig-like domain (group 1) Neurexophilin PF06312.7 KOO27578.1 - 0.00024 20.4 0.1 4.1 6.5 0.0 3.2 3 0 0 3 3 3 2 Neurexophilin Big_3_4 PF13754.1 KOO27578.1 - 0.004 17.4 11.3 4.8 7.5 0.1 5.5 6 0 0 6 6 6 2 Bacterial Ig-like domain (group 3) YtkA PF13115.1 KOO27578.1 - 0.0071 16.6 0.1 47 4.4 0.0 4.8 5 0 0 5 5 5 0 YtkA-like Big_3 PF07523.7 KOO27578.1 - 0.018 15.0 1.5 20 5.3 0.0 4.3 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 3) DUF3244 PF11589.3 KOO27578.1 - 0.11 12.2 0.1 1.5 8.5 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3244) FBPase PF00316.15 KOO27579.1 - 9.5e-52 175.8 0.0 3.2e-31 108.3 0.0 3.0 1 1 1 2 2 2 2 Fructose-1-6-bisphosphatase DUF1131 PF06572.7 KOO27579.1 - 0.1 12.0 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1131) Gly_transf_sug PF04488.10 KOO27581.1 - 1.6e-07 31.6 0.0 2.5e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 KOO27581.1 - 0.00018 20.1 0.0 0.00025 19.6 0.0 1.1 1 0 0 1 1 1 1 TcdA/TcdB catalytic glycosyltransferase domain DUF2214 PF09980.4 KOO27583.1 - 5.6e-46 155.9 2.6 7.5e-46 155.5 1.8 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2214) Sigma70_r3 PF04539.11 KOO27584.1 - 1.8e-08 34.1 25.3 0.066 13.1 0.7 7.5 4 1 3 7 7 7 6 Sigma-70 region 3 PIP5K PF01504.13 KOO27585.1 - 8.9e-68 228.1 0.0 1.4e-67 227.4 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase PSII_Pbs27 PF13326.1 KOO27585.1 - 0.057 13.3 0.2 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 Photosystem II Pbs27 Mito_fiss_reg PF05308.6 KOO27585.1 - 0.085 12.2 0.2 0.2 11.0 0.2 1.6 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.14 KOO27585.1 - 0.59 9.3 3.9 0.89 8.7 2.7 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Anoctamin PF04547.7 KOO27586.1 - 8.8e-99 331.1 0.0 1.6e-98 330.3 0.0 1.4 1 1 0 1 1 1 1 Calcium-activated chloride channel TPR_1 PF00515.23 KOO27586.1 - 0.036 13.6 0.0 0.16 11.6 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Aldo_ket_red PF00248.16 KOO27587.1 - 1.8e-23 82.7 0.0 2.3e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Pkinase PF00069.20 KOO27588.1 - 4.8e-52 176.6 0.0 5.7e-52 176.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27588.1 - 4e-37 127.6 0.0 4.8e-37 127.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO27588.1 - 5e-09 35.5 0.0 6.8e-09 35.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO27588.1 - 0.00082 19.1 0.4 0.0016 18.1 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinesin PF00225.18 KOO27589.1 - 4.5e-97 324.7 0.0 5.1e-97 324.5 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain Ank_2 PF12796.2 KOO27590.1 - 3.7e-20 72.0 6.4 2.1e-09 37.6 0.2 2.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO27590.1 - 4.6e-16 58.4 1.0 1e-06 28.8 0.1 3.7 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO27590.1 - 4e-14 52.6 0.0 2e-06 28.1 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO27590.1 - 6.1e-12 44.7 6.4 0.0089 15.8 0.1 4.3 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.1 KOO27590.1 - 1.6e-11 43.2 0.7 0.075 13.3 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Sulfotransfer_1 PF00685.22 KOO27591.1 - 3.8e-05 23.0 0.0 0.22 10.7 0.0 2.2 2 0 0 2 2 2 2 Sulfotransferase domain Sulfotransfer_3 PF13469.1 KOO27591.1 - 0.43 11.5 11.4 0.058 14.3 4.3 2.3 2 1 0 2 2 2 0 Sulfotransferase family WD40 PF00400.27 KOO27592.1 - 4.5e-15 54.8 0.3 6.1e-07 29.0 0.0 3.8 4 0 0 4 4 4 3 WD domain, G-beta repeat PQQ_3 PF13570.1 KOO27592.1 - 0.011 15.9 1.5 0.24 11.7 0.0 3.2 3 0 0 3 3 3 0 PQQ-like domain Exostosin PF03016.10 KOO27593.1 - 3.2e-35 121.6 0.2 2.7e-33 115.2 0.0 2.2 2 0 0 2 2 2 2 Exostosin family EGF_2 PF07974.8 KOO27593.1 - 3.7e-05 23.7 18.8 0.00068 19.7 6.5 2.5 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.2 KOO27593.1 - 0.1 12.6 10.4 0.72 10.0 1.5 2.9 2 0 0 2 2 2 0 Human growth factor-like EGF EGF PF00008.22 KOO27593.1 - 0.17 11.9 7.1 10 6.2 0.0 2.5 2 0 0 2 2 2 0 EGF-like domain DUF1997 PF09366.5 KOO27595.1 - 2.3e-10 40.4 0.0 2.5e-10 40.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1997) RNB PF00773.14 KOO27596.1 - 1.3e-57 195.5 0.0 5.4e-57 193.5 0.0 2.0 2 1 0 2 2 2 1 RNB domain MFS_1 PF07690.11 KOO27597.1 - 1.8e-10 40.1 14.8 1.8e-10 40.1 10.2 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily PseudoU_synth_2 PF00849.17 KOO27597.1 - 0.0057 16.4 0.0 0.0092 15.8 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase EF-hand_7 PF13499.1 KOO27598.1 - 1.6e-08 34.5 0.7 0.0027 17.8 0.0 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO27598.1 - 1e-07 30.7 5.9 4.7e-05 22.3 0.3 3.0 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO27598.1 - 3.8e-06 26.4 5.7 0.0021 17.6 0.1 2.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO27598.1 - 4.7e-05 22.9 6.4 0.0014 18.2 0.4 3.2 3 0 0 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO27598.1 - 0.023 14.7 0.2 0.045 13.7 0.2 1.6 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO27598.1 - 0.18 11.5 2.0 11 5.7 0.1 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.1 KOO27598.1 - 0.37 10.2 6.2 0.68 9.3 0.1 3.2 3 0 0 3 3 3 0 EF hand Pkinase PF00069.20 KOO27599.1 - 1.4e-45 155.4 0.0 1.8e-45 155.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27599.1 - 6.2e-12 45.1 0.0 1.4e-11 43.9 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase zf-RING_2 PF13639.1 KOO27601.1 - 2.6e-09 36.7 14.3 4.3e-09 36.0 9.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 KOO27601.1 - 7.6e-09 35.4 11.3 1.3e-08 34.7 7.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO27601.1 - 9.5e-08 31.5 9.4 1.5e-07 30.9 6.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO27601.1 - 1.2e-07 31.2 9.6 1.9e-07 30.6 6.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO27601.1 - 1.5e-05 24.5 13.0 2.6e-05 23.8 9.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 KOO27601.1 - 3.2e-05 23.5 3.4 3.2e-05 23.5 2.3 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 KOO27601.1 - 6.1e-05 22.8 11.6 0.0001 22.0 8.0 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.3 KOO27601.1 - 0.033 13.7 6.6 0.061 12.8 4.6 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-Apc11 PF12861.2 KOO27601.1 - 0.23 11.3 7.2 1.7 8.5 5.0 2.3 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FYVE PF01363.16 KOO27601.1 - 0.24 11.2 4.6 0.53 10.2 3.2 1.5 1 0 0 1 1 1 0 FYVE zinc finger zf-MIZ PF02891.15 KOO27601.1 - 0.26 10.8 11.2 0.47 10.0 7.8 1.4 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-rbx1 PF12678.2 KOO27601.1 - 1.6 8.8 8.6 7 6.8 6.0 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger Filamin PF00630.14 KOO27602.1 - 1.3e-147 481.5 0.0 3.7e-18 65.9 0.0 13.1 13 0 0 13 13 13 12 Filamin/ABP280 repeat YtkA PF13115.1 KOO27602.1 - 4e-11 43.1 4.4 3.2 8.1 0.0 10.4 12 0 0 12 12 12 2 YtkA-like Y_Y_Y PF07495.8 KOO27602.1 - 3.3e-05 23.5 4.2 5.8 6.7 0.0 6.3 6 0 0 6 6 6 1 Y_Y_Y domain Big_1 PF02369.11 KOO27602.1 - 0.0003 20.6 20.8 0.69 9.8 0.1 8.1 8 0 0 8 8 8 3 Bacterial Ig-like domain (group 1) Neurexophilin PF06312.7 KOO27602.1 - 0.0015 17.7 6.7 9.3 5.4 0.1 5.4 5 0 0 5 5 5 1 Neurexophilin Whib PF02467.11 KOO27603.1 - 5 7.5 6.3 0.56 10.5 0.1 2.4 3 1 0 3 3 3 0 Transcription factor WhiB U-box PF04564.10 KOO27605.1 - 4.2e-08 33.0 0.0 7.2e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-RING_UBOX PF13445.1 KOO27605.1 - 0.00039 20.0 0.0 0.0015 18.1 0.0 2.0 1 1 1 2 2 2 1 RING-type zinc-finger peroxidase PF00141.18 KOO27606.1 - 3.7e-38 131.2 0.0 5.6e-38 130.6 0.0 1.2 1 0 0 1 1 1 1 Peroxidase PP2C PF00481.16 KOO27607.1 - 8.7e-31 107.2 0.0 1.3e-30 106.6 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C cNMP_binding PF00027.24 KOO27607.1 - 2.1e-09 37.0 0.0 0.0026 17.5 0.0 3.2 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain AhpC-TSA_2 PF13911.1 KOO27607.1 - 3.9e-09 36.4 0.0 8.4e-09 35.3 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.16 KOO27607.1 - 2.5e-06 27.1 0.0 4.5e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family SpoIIE PF07228.7 KOO27607.1 - 9.9e-05 22.1 0.9 0.0045 16.7 0.0 2.4 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) Redoxin PF08534.5 KOO27607.1 - 0.033 13.7 0.0 0.086 12.3 0.0 1.6 1 0 0 1 1 1 0 Redoxin PDDEXK_1 PF12705.2 KOO27607.1 - 0.1 11.9 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily Thioredoxin_8 PF13905.1 KOO27607.1 - 0.11 12.6 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like adh_short PF00106.20 KOO27608.1 - 2.1e-22 79.7 0.1 2.7e-22 79.4 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOO27608.1 - 3e-10 40.0 0.0 4.1e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 KOO27608.1 - 0.00069 19.4 0.0 0.001 18.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 KOO27608.1 - 0.0096 15.9 0.0 1.1 9.2 0.0 2.2 2 0 0 2 2 2 2 NADH(P)-binding Eno-Rase_NADH_b PF12242.3 KOO27608.1 - 0.11 12.2 0.1 0.21 11.4 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase EF-hand_1 PF00036.27 KOO27609.1 - 4.7e-32 106.8 0.2 6.8e-07 28.1 0.0 5.9 5 0 0 5 5 5 5 EF hand EF-hand_6 PF13405.1 KOO27609.1 - 2e-31 105.0 0.9 3.5e-05 23.3 0.0 5.5 5 0 0 5 5 5 5 EF-hand domain EF-hand_7 PF13499.1 KOO27609.1 - 1e-25 89.6 0.6 4.8e-11 42.6 0.1 4.2 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO27609.1 - 4.6e-24 82.6 3.7 9.4e-06 24.7 0.0 5.5 5 0 0 5 5 5 5 EF hand EF-hand_8 PF13833.1 KOO27609.1 - 5e-20 70.8 0.2 1.7e-08 33.9 0.1 4.4 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO27609.1 - 9.9e-07 28.7 2.1 0.01 15.8 0.0 4.4 4 1 0 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOO27609.1 - 0.13 12.2 0.0 5.2 7.0 0.0 3.0 3 0 0 3 3 3 0 EF-hand domain Cystatin PF00031.16 KOO27610.1 - 0.00041 20.4 0.1 0.00072 19.6 0.0 1.4 1 1 0 1 1 1 1 Cystatin domain SAM_1 PF00536.25 KOO27611.1 - 8.9e-20 70.6 0.3 6.4e-14 51.8 0.0 3.0 3 0 0 3 3 2 2 SAM domain (Sterile alpha motif) MIT PF04212.13 KOO27611.1 - 3.3e-18 65.3 3.5 9e-18 63.9 0.6 2.8 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain SAM_2 PF07647.12 KOO27611.1 - 8.5e-16 57.5 2.0 4.6e-11 42.4 0.0 3.2 3 0 0 3 3 3 2 SAM domain (Sterile alpha motif) AAA PF00004.24 KOO27611.1 - 4.3e-14 52.8 0.1 1.2e-13 51.4 0.1 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 KOO27611.1 - 1.1e-06 27.8 0.2 2.2e-06 26.9 0.1 1.5 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KOO27611.1 - 5.2e-06 26.6 0.2 0.0075 16.4 0.0 3.1 2 1 1 3 3 2 2 AAA domain AAA_18 PF13238.1 KOO27611.1 - 3.8e-05 23.9 1.5 0.00066 19.9 0.0 2.9 3 0 0 3 3 2 1 AAA domain DUF1192 PF06698.6 KOO27611.1 - 0.00012 21.8 0.3 0.00051 19.7 0.2 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1192) AAA_17 PF13207.1 KOO27611.1 - 0.00012 22.9 0.5 0.00057 20.6 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.9 KOO27611.1 - 0.002 18.0 0.2 0.0047 16.8 0.1 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Viral_helicase1 PF01443.13 KOO27611.1 - 0.0024 17.4 0.0 0.0048 16.4 0.0 1.5 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase KTI12 PF08433.5 KOO27611.1 - 0.0034 16.6 0.0 0.0071 15.5 0.0 1.5 1 0 0 1 1 1 1 Chromatin associated protein KTI12 RNA_helicase PF00910.17 KOO27611.1 - 0.0077 16.3 0.2 0.044 13.9 0.0 2.3 2 0 0 2 2 2 1 RNA helicase AAA_16 PF13191.1 KOO27611.1 - 0.0077 16.2 0.0 0.025 14.5 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain NTPase_1 PF03266.10 KOO27611.1 - 0.0091 15.7 0.2 0.02 14.5 0.1 1.7 1 0 0 1 1 1 1 NTPase AAA_5 PF07728.9 KOO27611.1 - 0.0093 15.6 0.1 0.021 14.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 KOO27611.1 - 0.013 14.6 0.0 0.23 10.5 0.0 2.1 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI TPR_11 PF13414.1 KOO27611.1 - 0.023 14.3 0.3 0.21 11.2 0.1 2.5 2 0 0 2 2 2 0 TPR repeat Ribosomal_L12 PF00542.14 KOO27611.1 - 0.024 14.6 0.8 0.65 10.0 0.2 2.8 2 0 0 2 2 2 0 Ribosomal protein L7/L12 C-terminal domain AAA_19 PF13245.1 KOO27611.1 - 0.033 13.9 0.1 0.082 12.6 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain Tn7_Tnp_TnsA_C PF08721.6 KOO27611.1 - 0.041 13.8 0.0 2.3 8.3 0.0 3.1 2 1 1 3 3 2 0 TnsA endonuclease C terminal AAA_10 PF12846.2 KOO27611.1 - 0.075 12.4 1.8 3.5 6.9 0.1 2.9 2 1 0 3 3 3 0 AAA-like domain AAA_33 PF13671.1 KOO27611.1 - 0.085 12.7 0.2 0.44 10.4 0.0 2.4 2 0 0 2 2 1 0 AAA domain tRNA_lig_kinase PF08303.6 KOO27611.1 - 0.085 12.7 0.3 0.8 9.5 0.0 2.6 2 2 1 4 4 3 0 tRNA ligase kinase domain TPR_2 PF07719.12 KOO27611.1 - 0.1 12.5 0.7 0.67 10.0 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat EF-1_beta_acid PF10587.4 KOO27611.1 - 0.86 9.8 7.7 0.12 12.5 1.6 2.4 2 0 0 2 2 2 0 Eukaryotic elongation factor 1 beta central acidic region SpaB_C PF14028.1 KOO27612.1 - 0.067 12.7 0.1 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 SpaB C-terminal domain Adeno_VII PF03228.9 KOO27613.1 - 0.084 13.4 1.6 0.2 12.2 1.1 1.7 1 0 0 1 1 1 0 Adenoviral core protein VII CbiG_mid PF11761.3 KOO27613.1 - 1.2 9.4 4.7 2.8 8.2 2.3 2.4 2 1 0 2 2 2 0 Cobalamin biosynthesis central region Saccharop_dh PF03435.13 KOO27614.1 - 2e-17 63.2 0.1 2.9e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase NAD_binding_10 PF13460.1 KOO27614.1 - 0.0022 18.0 0.0 0.0048 16.9 0.0 1.6 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 KOO27614.1 - 0.12 11.7 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family BetaGal_dom3 PF13363.1 KOO27615.1 - 0.068 12.5 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 Beta-galactosidase, domain 3 PDZ PF00595.19 KOO27617.1 - 2.3e-05 24.4 0.1 4.4e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO27617.1 - 0.0024 17.7 0.2 0.0046 16.8 0.1 1.4 1 0 0 1 1 1 1 PDZ domain AFG1_ATPase PF03969.11 KOO27618.1 - 1.8e-35 122.4 0.3 2.3e-29 102.3 0.0 2.0 2 0 0 2 2 2 2 AFG1-like ATPase Mtc PF03820.12 KOO27619.1 - 2.4e-21 75.6 0.0 4.5e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 Tricarboxylate carrier Fer2 PF00111.22 KOO27619.1 - 7e-05 22.4 1.2 0.0001 21.9 0.2 1.7 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer2_3 PF13085.1 KOO27619.1 - 0.0061 16.3 0.4 0.011 15.5 0.3 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Med14 PF08638.6 KOO27620.1 - 1.9e-14 53.3 0.0 4.1e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 Mediator complex subunit MED14 Pkinase PF00069.20 KOO27621.1 - 5.1e-23 81.5 0.0 8.9e-23 80.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27621.1 - 3.2e-19 69.0 0.0 5.2e-19 68.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO27621.1 - 0.0061 16.3 1.0 0.0061 16.3 0.7 3.2 3 1 1 4 4 4 1 Phosphotransferase enzyme family Anoctamin PF04547.7 KOO27622.1 - 5.6e-88 295.5 0.0 7.9e-59 199.4 0.0 2.2 1 1 1 2 2 2 2 Calcium-activated chloride channel C2 PF00168.25 KOO27622.1 - 1.4e-15 56.9 0.0 2.5e-11 43.2 0.0 2.5 2 0 0 2 2 2 2 C2 domain DUF3261 PF11659.3 KOO27622.1 - 0.083 12.4 0.0 0.28 10.7 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3261) Filament PF00038.16 KOO27623.1 - 0.0043 16.5 18.6 0.0043 16.5 12.9 2.1 1 1 1 2 2 2 1 Intermediate filament protein Amino_oxidase PF01593.19 KOO27623.1 - 0.014 14.4 1.7 0.017 14.2 1.1 1.1 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase TelA PF05816.6 KOO27623.1 - 0.016 13.9 20.8 0.052 12.2 9.1 2.1 1 1 1 2 2 2 0 Toxic anion resistance protein (TelA) Spc7 PF08317.6 KOO27623.1 - 0.078 11.6 19.9 0.12 11.0 5.6 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF2895 PF11444.3 KOO27623.1 - 0.12 11.5 0.6 0.25 10.5 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2895) TPR_MLP1_2 PF07926.7 KOO27623.1 - 0.15 11.8 30.1 0.48 10.1 5.7 3.0 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein CALCOCO1 PF07888.6 KOO27623.1 - 0.15 10.3 22.0 0.18 10.0 15.2 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Myosin_tail_1 PF01576.14 KOO27623.1 - 0.17 9.5 32.9 0.48 8.0 21.9 1.8 1 1 0 1 1 1 0 Myosin tail DUF4201 PF13870.1 KOO27623.1 - 0.63 9.4 18.9 0.22 10.9 1.9 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) ATG16 PF08614.6 KOO27623.1 - 0.85 9.4 24.2 2.8 7.7 2.8 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) IncA PF04156.9 KOO27623.1 - 1.8 8.0 25.4 2.7 7.5 7.3 2.2 1 1 1 2 2 2 0 IncA protein AAA_13 PF13166.1 KOO27623.1 - 2.7 6.3 16.3 3.6 5.9 11.3 1.2 1 0 0 1 1 1 0 AAA domain DUF1319 PF07028.6 KOO27623.1 - 3.3 7.9 10.5 0.43 10.7 0.8 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1319) Seryl_tRNA_N PF02403.17 KOO27623.1 - 4.4 7.3 24.2 4.4 7.3 2.6 2.6 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Syntaxin-6_N PF09177.6 KOO27623.1 - 5.4 7.4 16.2 2 8.8 2.7 2.9 1 1 2 3 3 3 0 Syntaxin 6, N-terminal CAP160 PF07918.6 KOO27623.1 - 7.2 6.3 7.2 10 5.8 1.5 3.3 3 0 0 3 3 3 0 CAP160 repeat Bacillus_HBL PF05791.6 KOO27623.1 - 7.4 5.9 13.1 2 7.7 1.0 2.2 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Prefoldin PF02996.12 KOO27623.1 - 8.9 5.9 18.1 3.4 7.3 0.3 3.9 2 2 3 5 5 5 0 Prefoldin subunit Kinesin PF00225.18 KOO27624.1 - 9e-28 96.9 0.0 1.6e-27 96.0 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain TPR_12 PF13424.1 KOO27624.1 - 3e-12 46.3 5.6 1.4e-08 34.5 0.7 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat VHS PF00790.14 KOO27624.1 - 2e-06 27.4 0.1 6e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 VHS domain TPR_11 PF13414.1 KOO27624.1 - 0.0011 18.5 11.2 0.0078 15.8 0.0 4.0 3 1 1 4 4 4 2 TPR repeat TPR_1 PF00515.23 KOO27624.1 - 0.0024 17.3 5.1 1.2 8.8 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO27624.1 - 0.0037 17.0 11.0 4.6 7.4 0.1 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO27624.1 - 0.0082 16.7 2.9 0.0082 16.7 2.0 4.2 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO27624.1 - 0.037 13.7 0.1 22 5.1 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 KOO27624.1 - 0.11 12.4 10.3 1.6 8.7 0.3 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO27624.1 - 0.15 11.9 9.6 8.6 6.4 0.1 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat NPV_P10 PF05531.7 KOO27624.1 - 0.79 10.0 3.4 7.4 6.9 0.5 3.2 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DivIC PF04977.10 KOO27624.1 - 9 5.8 11.8 19 4.8 0.2 4.1 2 2 1 3 3 3 0 Septum formation initiator DnaJ PF00226.26 KOO27625.1 - 3.2e-17 62.0 0.2 3.2e-17 62.0 0.1 1.8 2 0 0 2 2 2 1 DnaJ domain WW PF00397.21 KOO27625.1 - 2.5e-06 27.2 2.0 4.5e-06 26.4 1.4 1.5 1 0 0 1 1 1 1 WW domain Caps_synth PF05704.7 KOO27626.1 - 1.1e-08 34.5 0.0 2.2e-08 33.5 0.0 1.5 1 1 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.10 KOO27626.1 - 3.1e-05 24.2 0.1 0.00015 22.0 0.1 2.1 2 1 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif ABC2_membrane PF01061.19 KOO27628.1 - 2.1e-27 95.6 12.3 2.1e-27 95.6 8.5 1.8 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.22 KOO27628.1 - 9.5e-24 84.2 0.0 1.3e-23 83.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 KOO27628.1 - 8.2e-10 39.1 0.0 6.6e-05 23.0 0.0 2.2 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.14 KOO27628.1 - 2e-05 23.9 0.2 0.02 14.1 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain DUF258 PF03193.11 KOO27628.1 - 0.00032 19.9 0.1 0.00051 19.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ABC2_membrane_3 PF12698.2 KOO27628.1 - 0.00037 19.6 21.3 0.00056 19.0 14.6 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_29 PF13555.1 KOO27628.1 - 0.00043 19.7 0.1 0.00099 18.5 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 KOO27628.1 - 0.0014 17.7 0.0 0.56 9.1 0.0 2.1 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.1 KOO27628.1 - 0.0025 17.2 0.4 0.061 12.7 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 KOO27628.1 - 0.0076 16.3 0.1 0.025 14.6 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 KOO27628.1 - 0.019 15.1 0.2 0.069 13.3 0.1 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO27628.1 - 0.029 14.3 0.1 0.052 13.5 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.1 KOO27628.1 - 0.071 12.9 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.20 KOO27628.1 - 0.071 12.5 0.8 0.11 11.9 0.6 1.4 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain PduV-EutP PF10662.4 KOO27628.1 - 0.08 12.4 0.2 0.15 11.5 0.1 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Arch_ATPase PF01637.13 KOO27628.1 - 0.099 12.3 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase AAA_23 PF13476.1 KOO27628.1 - 0.099 12.9 0.1 0.16 12.3 0.1 1.2 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 KOO27628.1 - 0.12 12.3 0.0 0.6 10.0 0.1 2.1 3 0 0 3 3 3 0 AAA domain Rad17 PF03215.10 KOO27628.1 - 0.32 9.6 0.1 0.45 9.1 0.1 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_19 PF13245.1 KOO27628.1 - 0.36 10.6 2.9 0.31 10.8 0.3 2.2 2 0 0 2 2 2 0 Part of AAA domain Thioredoxin_2 PF13098.1 KOO27629.1 - 0.0006 19.9 0.0 0.00076 19.6 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain EF-hand_7 PF13499.1 KOO27630.1 - 7.3e-24 83.6 0.0 1e-11 44.8 0.0 3.9 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO27630.1 - 1.1e-23 80.7 5.1 7.6e-06 24.8 0.0 6.5 6 0 0 6 6 6 4 EF hand EF-hand_6 PF13405.1 KOO27630.1 - 3.6e-22 76.1 2.4 3.4e-05 23.3 0.0 6.2 6 0 0 6 6 6 4 EF-hand domain EF-hand_8 PF13833.1 KOO27630.1 - 7.3e-21 73.5 0.0 2.1e-05 24.0 0.0 4.3 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO27630.1 - 4e-14 51.2 5.0 0.0022 17.2 0.0 5.7 6 0 0 6 6 6 3 EF hand EF-hand_10 PF14788.1 KOO27630.1 - 0.0022 17.6 0.1 0.039 13.6 0.0 2.5 2 0 0 2 2 2 1 EF hand DUF3856 PF12968.2 KOO27630.1 - 0.053 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF3856) Ribul_P_3_epim PF00834.14 KOO27631.1 - 1.2e-68 230.1 0.9 3.8e-66 222.0 0.6 2.1 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.14 KOO27631.1 - 2e-07 30.6 0.1 0.0003 20.3 0.0 2.2 2 0 0 2 2 2 2 Quinolinate phosphoribosyl transferase, C-terminal domain His_biosynth PF00977.16 KOO27631.1 - 0.008 15.4 0.1 0.14 11.4 0.0 2.1 2 0 0 2 2 2 1 Histidine biosynthesis protein TMP-TENI PF02581.12 KOO27631.1 - 0.015 14.4 0.4 0.23 10.5 0.1 2.6 3 0 0 3 3 3 0 Thiamine monophosphate synthase/TENI DUF1995 PF09353.5 KOO27632.1 - 6.4e-07 29.1 0.0 8.5e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1995) Ank_2 PF12796.2 KOO27633.1 - 1.4e-19 70.2 3.1 8.8e-10 38.8 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO27633.1 - 1.9e-15 55.8 0.2 1.3e-07 31.0 0.0 4.1 3 1 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOO27633.1 - 2.2e-12 47.1 1.3 3.6e-06 27.3 0.1 4.3 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO27633.1 - 1.9e-11 43.8 0.9 0.0015 18.7 0.0 4.6 4 1 0 4 4 4 3 Ankyrin repeats (many copies) EF-hand_1 PF00036.27 KOO27633.1 - 6.5e-11 40.7 3.4 0.00012 21.0 0.1 2.8 2 0 0 2 2 2 2 EF hand Ank_3 PF13606.1 KOO27633.1 - 2.1e-10 39.8 0.3 0.00025 20.9 0.0 5.1 5 1 1 6 6 5 2 Ankyrin repeat EF-hand_7 PF13499.1 KOO27633.1 - 1.1e-07 31.8 0.3 3.1e-07 30.4 0.2 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO27633.1 - 5.4e-05 22.7 0.5 0.12 12.3 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO27633.1 - 6.3e-05 22.5 6.7 0.012 15.1 1.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair Inhibitor_I34 PF10466.4 KOO27633.1 - 0.06 13.4 0.5 10 6.2 0.0 3.3 3 0 0 3 3 3 0 Saccharopepsin inhibitor I34 EF-hand_5 PF13202.1 KOO27633.1 - 0.71 9.3 0.0 0.71 9.3 0.0 2.8 3 1 0 3 3 3 0 EF hand BT1 PF03092.11 KOO27634.1 - 1.5e-16 60.1 13.5 2.1e-16 59.7 9.4 1.2 1 0 0 1 1 1 1 BT1 family Methyltransf_24 PF13578.1 KOO27634.1 - 0.015 16.1 0.0 0.031 15.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Na_Ca_ex PF01699.19 KOO27635.1 - 6.1e-21 74.5 10.8 6.1e-21 74.5 7.5 1.5 2 0 0 2 2 2 1 Sodium/calcium exchanger protein Calx-beta PF03160.9 KOO27635.1 - 0.0022 17.8 0.2 0.0049 16.7 0.0 1.6 2 0 0 2 2 2 1 Calx-beta domain Nuc_sug_transp PF04142.10 KOO27636.1 - 2.4e-28 98.8 14.6 5.3e-28 97.7 10.1 1.5 1 0 0 1 1 1 1 Nucleotide-sugar transporter Ion_trans_2 PF07885.11 KOO27636.1 - 1.7e-09 37.2 19.0 5.8e-07 29.1 2.7 3.9 3 0 0 3 3 3 2 Ion channel ATG16 PF08614.6 KOO27637.1 - 2.2 8.0 39.8 0.21 11.3 14.3 3.0 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Reo_sigmaC PF04582.7 KOO27637.1 - 4.9 6.2 9.3 0.79 8.8 2.0 2.4 1 1 2 3 3 3 0 Reovirus sigma C capsid protein Mob_Pre PF01076.14 KOO27638.1 - 0.0041 16.7 0.3 0.0054 16.4 0.2 1.3 1 0 0 1 1 1 1 Plasmid recombination enzyme DSPc PF00782.15 KOO27639.1 - 2.5e-07 30.3 0.0 3.9e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 KOO27639.1 - 2.8e-05 24.1 0.0 5.5e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.1 KOO27639.1 - 0.00028 21.1 0.1 0.00055 20.2 0.1 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 KOO27639.1 - 0.0025 17.1 0.0 0.0036 16.6 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTEN_C2 PF10409.4 KOO27639.1 - 0.0039 16.9 0.0 0.0067 16.1 0.0 1.3 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein MAP7 PF05672.6 KOO27641.1 - 0.016 14.6 5.3 0.019 14.3 3.7 1.1 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family CBP4 PF07960.6 KOO27641.1 - 0.05 13.2 2.4 0.077 12.6 1.7 1.4 1 1 0 1 1 1 0 CBP4 HisKA_2 PF07568.7 KOO27641.1 - 0.18 11.6 0.9 0.28 11.0 0.1 1.6 2 0 0 2 2 2 0 Histidine kinase PSD5 PF07637.6 KOO27641.1 - 1.6 8.8 4.4 8.3 6.5 0.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1595) Na_Ca_ex PF01699.19 KOO27642.1 - 1.1e-39 135.2 24.5 7.4e-23 80.7 7.2 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Calx-beta PF03160.9 KOO27642.1 - 1.9e-36 123.9 1.2 5.7e-21 74.3 0.2 2.3 2 0 0 2 2 2 2 Calx-beta domain Chloroa_b-bind PF00504.16 KOO27643.1 - 1.2e-35 123.1 0.1 1.5e-35 122.7 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein DAO PF01266.19 KOO27643.1 - 0.0093 14.8 0.1 0.012 14.5 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Seryl_tRNA_N PF02403.17 KOO27644.1 - 0.063 13.2 0.4 0.063 13.2 0.3 3.8 5 0 0 5 5 5 0 Seryl-tRNA synthetase N-terminal domain COG2 PF06148.6 KOO27644.1 - 0.14 11.9 0.1 0.14 11.9 0.1 2.7 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Baculo_PEP_C PF04513.7 KOO27644.1 - 8.8 6.1 12.7 6.4 6.5 0.2 3.4 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2061 PF09834.4 KOO27646.1 - 0.045 13.9 2.4 0.045 13.9 1.6 3.3 4 0 0 4 4 4 0 Predicted membrane protein (DUF2061) Peptidase_M3 PF01432.15 KOO27647.1 - 5.6e-21 75.1 0.0 2.5e-20 72.9 0.0 1.9 1 1 0 1 1 1 1 Peptidase family M3 DUF4033 PF13225.1 KOO27648.1 - 1.2e-15 56.8 0.1 1.8e-15 56.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4033) Fasciclin PF02469.17 KOO27650.1 - 4.2e-10 39.7 0.0 7.6e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 Fasciclin domain Ras PF00071.17 KOO27651.1 - 7.2e-17 61.2 0.0 8.7e-17 60.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO27651.1 - 5.5e-11 43.0 0.0 7.6e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO27651.1 - 0.13 11.4 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family Macoilin PF09726.4 KOO27652.1 - 0.66 8.1 3.4 0.91 7.7 2.3 1.1 1 0 0 1 1 1 0 Transmembrane protein Peptidase_S10 PF00450.17 KOO27653.1 - 7.2e-86 288.9 0.0 9.6e-86 288.5 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Thioredoxin PF00085.15 KOO27653.1 - 1.4e-07 31.0 0.0 3e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 KOO27653.1 - 0.34 11.0 0.0 0.72 10.0 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like TraF PF13728.1 KOO27653.1 - 0.39 10.1 0.0 0.61 9.5 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Tropomyosin PF00261.15 KOO27654.1 - 0.00011 21.3 6.0 0.00011 21.3 4.2 1.6 2 0 0 2 2 2 1 Tropomyosin CENP-F_leu_zip PF10473.4 KOO27654.1 - 0.00055 19.8 9.2 0.0013 18.6 6.4 1.5 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.6 KOO27654.1 - 0.0054 15.4 7.6 0.0054 15.4 5.3 1.5 2 0 0 2 2 2 1 Spc7 kinetochore protein TMF_DNA_bd PF12329.3 KOO27654.1 - 0.0091 15.7 12.7 0.048 13.4 6.9 2.2 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding Fmp27_WPPW PF10359.4 KOO27654.1 - 0.0093 14.4 3.2 0.015 13.7 2.2 1.3 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2360 PF10152.4 KOO27654.1 - 0.011 16.0 0.1 0.022 15.0 0.1 1.6 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) zf-C4H2 PF10146.4 KOO27654.1 - 0.02 14.9 0.0 0.04 13.9 0.0 1.6 1 1 0 1 1 1 0 Zinc finger-containing protein Lectin_N PF03954.9 KOO27654.1 - 0.033 13.5 5.2 0.12 11.7 2.9 2.1 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain Mnd1 PF03962.10 KOO27654.1 - 0.042 13.5 11.0 0.026 14.2 5.8 1.7 2 0 0 2 2 2 0 Mnd1 family MT PF12777.2 KOO27654.1 - 0.043 12.5 0.7 0.095 11.4 0.4 1.5 2 0 0 2 2 2 0 Microtubule-binding stalk of dynein motor ATG16 PF08614.6 KOO27654.1 - 0.063 13.0 10.3 0.13 12.0 5.7 2.0 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Prefoldin_3 PF13758.1 KOO27654.1 - 0.079 12.7 5.4 3.1 7.6 0.0 2.7 2 1 1 3 3 3 0 Prefoldin subunit UPF0560 PF10577.4 KOO27654.1 - 0.15 10.3 2.8 0.19 9.9 2.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Atg14 PF10186.4 KOO27654.1 - 0.19 10.6 12.1 0.081 11.8 6.5 1.6 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Lipoprotein_20 PF13942.1 KOO27654.1 - 0.28 10.7 6.5 0.51 9.8 4.5 1.4 1 0 0 1 1 1 0 YfhG lipoprotein Effector_1 PF04518.7 KOO27654.1 - 0.28 10.1 4.7 0.13 11.2 1.7 1.5 2 0 0 2 2 2 0 Effector from type III secretion system ADIP PF11559.3 KOO27654.1 - 0.31 10.9 14.9 0.035 14.0 6.5 1.9 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding V_ATPase_I PF01496.14 KOO27654.1 - 0.54 8.0 2.7 0.82 7.4 1.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family APG6 PF04111.7 KOO27654.1 - 0.62 9.0 13.5 0.33 9.9 7.1 1.8 2 0 0 2 2 2 0 Autophagy protein Apg6 BLOC1_2 PF10046.4 KOO27654.1 - 0.69 10.0 7.4 1.3 9.2 0.8 2.8 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 YscO PF07321.7 KOO27654.1 - 0.71 9.6 19.7 0.24 11.1 9.2 2.5 2 1 1 3 3 3 0 Type III secretion protein YscO Tropomyosin_1 PF12718.2 KOO27654.1 - 0.88 9.4 12.0 0.6 9.9 5.8 2.0 2 0 0 2 2 2 0 Tropomyosin like TBPIP PF07106.8 KOO27654.1 - 2.3 7.7 8.0 1.4 8.4 2.6 2.3 2 1 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) HAUS-augmin3 PF14932.1 KOO27654.1 - 2.4 7.2 11.9 0.96 8.5 6.5 1.5 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 Fib_alpha PF08702.5 KOO27654.1 - 2.5 8.2 8.3 0.26 11.4 0.9 2.4 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF972 PF06156.8 KOO27654.1 - 3.3 8.0 6.5 1.9 8.8 1.4 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF972) DUF904 PF06005.7 KOO27654.1 - 4.3 7.7 11.9 1.5 9.1 5.5 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF904) Seryl_tRNA_N PF02403.17 KOO27654.1 - 7.1 6.6 9.5 2.7 8.0 4.4 1.8 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4200 PF13863.1 KOO27654.1 - 8.9 6.2 17.6 18 5.2 7.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Ank_2 PF12796.2 KOO27656.1 - 3.5e-55 184.3 10.5 5.7e-18 65.0 0.0 4.8 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 KOO27656.1 - 1.8e-42 141.0 16.6 7.6e-07 28.6 0.0 9.2 9 0 0 9 9 9 7 Ankyrin repeat Ank_4 PF13637.1 KOO27656.1 - 3.4e-39 132.5 12.3 7.6e-11 42.2 0.1 7.4 4 2 4 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO27656.1 - 9.8e-38 124.4 6.5 0.0001 22.2 0.0 8.9 9 0 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.1 KOO27656.1 - 1e-29 101.8 13.5 1.3e-05 25.2 0.7 8.4 3 2 5 8 8 8 7 Ankyrin repeats (many copies) DUF4182 PF13790.1 KOO27656.1 - 0.03 14.1 0.0 3.7 7.4 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4182) zf-CHY PF05495.7 KOO27657.1 - 2e-13 50.2 19.2 6e-12 45.5 6.9 3.4 3 0 0 3 3 3 2 CHY zinc finger ResB PF05140.9 KOO27657.1 - 1.6 7.1 3.5 2.7 6.4 2.2 1.5 1 1 0 1 1 1 0 ResB-like family EF-hand_1 PF00036.27 KOO27658.1 - 1.5e-17 61.4 0.5 8.9e-09 34.0 0.1 2.2 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO27658.1 - 1.4e-15 55.6 1.0 7.8e-08 31.5 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO27658.1 - 3.4e-14 52.1 0.0 2.8e-06 26.8 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO27658.1 - 5e-13 47.7 1.0 6.8e-07 28.3 0.2 2.2 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO27658.1 - 5.4e-13 48.8 0.0 7.6e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_10 PF14788.1 KOO27658.1 - 0.0034 16.9 0.1 1.7 8.3 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.2 KOO27658.1 - 0.0056 16.3 0.0 1.1 8.9 0.0 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO27658.1 - 0.077 12.9 0.0 0.51 10.2 0.0 2.0 1 1 0 1 1 1 0 EF-hand domain Diphthamide_syn PF01866.12 KOO27659.1 - 6.8e-107 357.2 0.0 8.2e-107 356.9 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Acetyltransf_1 PF00583.19 KOO27659.1 - 2.8e-13 49.6 0.5 9.4e-13 48.0 0.0 2.1 3 0 0 3 3 3 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 KOO27659.1 - 2.6e-09 37.2 0.3 5.2e-08 33.0 0.2 2.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 KOO27659.1 - 1.7e-06 28.0 0.0 3.7e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 KOO27659.1 - 2.8e-05 23.7 0.0 5.2e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.1 KOO27659.1 - 5e-05 23.2 0.0 9e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 KOO27659.1 - 0.0096 15.8 0.0 0.016 15.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 KOO27659.1 - 0.013 15.3 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 KOO27659.1 - 0.088 12.7 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase EF-hand_1 PF00036.27 KOO27660.1 - 8.7e-28 93.4 16.6 3.5e-06 25.9 0.1 6.9 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.1 KOO27660.1 - 3.3e-25 85.6 13.7 2e-05 24.0 0.0 7.0 6 0 0 6 6 6 5 EF-hand domain EF-hand_7 PF13499.1 KOO27660.1 - 5.5e-23 80.8 13.1 9.2e-09 35.3 0.2 6.2 4 1 3 7 7 7 6 EF-hand domain pair EF-hand_5 PF13202.1 KOO27660.1 - 1.8e-21 74.4 11.0 6.3e-05 22.1 0.2 6.3 5 0 0 5 5 5 5 EF hand EF-hand_8 PF13833.1 KOO27660.1 - 1.9e-14 52.9 13.2 0.0025 17.3 0.0 6.4 4 1 1 5 5 5 5 EF-hand domain pair Adeno_VII PF03228.9 KOO27660.1 - 0.0045 17.5 1.3 0.0045 17.5 0.9 14.0 17 0 0 17 17 17 1 Adenoviral core protein VII Gmad2 PF10648.4 KOO27661.1 - 0.13 12.4 0.1 0.23 11.6 0.1 1.4 1 0 0 1 1 1 0 Immunoglobulin-like domain of bacterial spore germination VPS11_C PF12451.3 KOO27662.1 - 0.013 15.3 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 Vacuolar protein sorting protein 11 C terminal Ribosomal_60s PF00428.14 KOO27662.1 - 2.9 8.3 8.1 4.1 7.8 5.6 1.3 1 1 0 1 1 1 0 60s Acidic ribosomal protein Chromo PF00385.19 KOO27663.1 - 1.1e-14 53.7 1.2 2.1e-14 52.9 0.8 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Pkinase PF00069.20 KOO27664.1 - 1.2e-44 152.4 0.0 1.5e-44 152.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27664.1 - 7.2e-25 87.5 0.0 9e-25 87.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO27664.1 - 0.00038 19.5 0.0 0.00061 18.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO27664.1 - 0.0036 17.0 0.2 0.024 14.3 0.0 2.0 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 KOO27664.1 - 0.092 11.7 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YbaB_DNA_bd PF02575.11 KOO27665.1 - 4.5e-13 48.9 4.5 8.2e-13 48.0 3.1 1.5 1 1 0 1 1 1 1 YbaB/EbfC DNA-binding family MFS_1 PF07690.11 KOO27666.1 - 5.3e-14 51.7 49.7 3e-08 32.7 23.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily RNA_pol_Rbc25 PF08292.7 KOO27667.1 - 2.8e-29 101.8 0.0 1.3e-28 99.6 0.0 1.8 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.12 KOO27667.1 - 3.5e-16 59.0 0.1 5.4e-16 58.4 0.1 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 DUF3720 PF12517.3 KOO27667.1 - 4 8.1 9.6 13 6.5 6.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3720) RrnaAD PF00398.15 KOO27668.1 - 3.5e-54 183.5 0.0 4.3e-54 183.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_26 PF13659.1 KOO27668.1 - 2.5e-09 37.2 0.4 1.6e-08 34.5 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO27668.1 - 6.1e-06 26.7 0.0 1.4e-05 25.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO27668.1 - 0.0001 21.9 0.0 0.00021 20.8 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 KOO27668.1 - 0.005 16.2 0.0 0.008 15.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.14 KOO27668.1 - 0.0085 15.6 0.0 0.013 15.0 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.7 KOO27668.1 - 0.026 14.9 0.0 0.057 13.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 KOO27668.1 - 0.048 14.1 0.0 0.087 13.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 KOO27668.1 - 0.063 13.0 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.1 KOO27668.1 - 0.068 13.5 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_15 PF09445.5 KOO27668.1 - 0.077 12.5 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase DREV PF05219.7 KOO27668.1 - 0.1 11.4 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Ubie_methyltran PF01209.13 KOO27668.1 - 0.17 11.0 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family MRG PF05712.8 KOO27670.1 - 4.9e-42 143.0 0.1 6.9e-42 142.5 0.0 1.1 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.3 KOO27670.1 - 6.8e-06 25.6 0.0 1.2e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.19 KOO27670.1 - 0.0084 15.7 0.0 0.022 14.4 0.0 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Ribonuc_2-5A PF06479.7 KOO27670.1 - 0.019 14.8 0.0 0.082 12.7 0.0 2.0 2 0 0 2 2 2 0 Ribonuclease 2-5A Dynactin_p22 PF07426.6 KOO27670.1 - 0.047 12.9 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Dynactin subunit p22 TM140 PF14985.1 KOO27670.1 - 0.049 13.3 0.0 0.076 12.6 0.0 1.2 1 0 0 1 1 1 0 TM140 protein family Histidinol_dh PF00815.15 KOO27671.1 - 3e-88 296.2 6.2 4.2e-88 295.7 4.3 1.1 1 0 0 1 1 1 1 Histidinol dehydrogenase HisG PF01634.13 KOO27671.1 - 3.5e-43 147.0 0.0 7.2e-43 145.9 0.0 1.6 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.6 KOO27671.1 - 1.5e-22 79.2 0.3 4.5e-22 77.7 0.0 2.0 2 0 0 2 2 2 1 HisG, C-terminal domain ABC2_membrane PF01061.19 KOO27672.1 - 9e-42 142.6 16.3 1.5e-41 141.8 11.3 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.22 KOO27672.1 - 7.7e-18 65.1 0.0 1.2e-17 64.4 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 KOO27672.1 - 1.8e-05 24.8 0.1 0.12 12.3 0.0 2.5 3 0 0 3 3 2 2 AAA domain AAA_25 PF13481.1 KOO27672.1 - 0.0003 20.2 0.1 0.0052 16.2 0.1 2.4 2 0 0 2 2 2 1 AAA domain ABC2_membrane_3 PF12698.2 KOO27672.1 - 0.0012 17.9 14.1 0.0012 17.9 9.7 2.0 1 1 1 2 2 2 1 ABC-2 family transporter protein AAA_16 PF13191.1 KOO27672.1 - 0.0012 18.8 0.0 0.0033 17.4 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 KOO27672.1 - 0.0015 19.3 0.0 0.0031 18.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.11 KOO27672.1 - 0.0072 15.5 0.1 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 KOO27672.1 - 0.01 16.0 0.0 0.037 14.1 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.1 KOO27672.1 - 0.015 14.8 0.1 0.041 13.4 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.1 KOO27672.1 - 0.021 14.7 0.1 0.037 13.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain DUF503 PF04456.7 KOO27672.1 - 0.024 14.2 0.1 0.051 13.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF503) SMC_N PF02463.14 KOO27672.1 - 0.054 12.7 0.1 0.74 8.9 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA PF00004.24 KOO27672.1 - 0.066 13.4 0.0 0.52 10.5 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) IIGP PF05049.8 KOO27672.1 - 0.071 11.9 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Miro PF08477.8 KOO27672.1 - 0.11 13.0 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein ATP_bind_1 PF03029.12 KOO27672.1 - 0.11 11.9 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.18 KOO27672.1 - 0.15 11.8 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Dynamin family ABC2_membrane_2 PF12679.2 KOO27672.1 - 0.16 10.8 8.8 0.074 11.8 2.9 2.2 1 1 1 2 2 2 0 ABC-2 family transporter protein MMR_HSR1 PF01926.18 KOO27672.1 - 0.18 11.7 0.0 0.41 10.6 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.1 KOO27672.1 - 0.2 11.9 0.0 0.33 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain Shisa PF13908.1 KOO27674.1 - 0.085 13.0 0.0 0.1 12.7 0.0 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator TP6A_N PF04406.9 KOO27675.1 - 4.2e-06 26.3 0.0 8.7e-06 25.3 0.0 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase Prismane PF03063.15 KOO27675.1 - 0.96 7.7 0.0 1.5 7.0 0.0 1.2 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family Gly_acyl_tr_C PF08444.5 KOO27675.1 - 8.6 6.4 7.2 9.3 6.3 0.0 4.3 5 1 1 6 6 6 0 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region EF-hand_1 PF00036.27 KOO27676.1 - 5.6e-11 40.9 0.0 4.9e-05 22.3 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO27676.1 - 1e-09 37.8 0.1 4.5e-09 35.7 0.0 1.9 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.1 KOO27676.1 - 1.4e-09 37.9 0.0 2.4e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO27676.1 - 4.1e-09 35.3 0.3 0.0021 17.2 0.1 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO27676.1 - 1.1e-08 34.2 0.1 0.00032 20.3 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 KOO27676.1 - 0.042 13.5 0.0 0.07 12.8 0.0 1.3 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO27676.1 - 0.1 12.6 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region GST_C_3 PF14497.1 KOO27677.1 - 0.00015 22.2 0.0 0.00021 21.6 0.0 1.4 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 KOO27677.1 - 0.00039 20.3 0.0 0.00093 19.1 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 KOO27677.1 - 0.0034 17.5 0.0 0.0078 16.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KOO27677.1 - 0.019 14.8 0.0 0.043 13.6 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Ras PF00071.17 KOO27678.1 - 8.6e-65 217.0 0.6 1e-64 216.7 0.4 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO27678.1 - 6.6e-22 78.2 0.1 6.6e-22 78.2 0.1 1.7 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 KOO27678.1 - 6.4e-18 64.6 0.2 8.2e-18 64.2 0.2 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KOO27678.1 - 1.9e-06 27.2 0.1 2.4e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 KOO27678.1 - 4.8e-06 25.9 1.3 5.8e-06 25.6 0.0 1.6 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 KOO27678.1 - 5.1e-06 26.0 0.4 1.6e-05 24.4 0.3 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOO27678.1 - 5.5e-06 26.3 0.1 1.1e-05 25.3 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 KOO27678.1 - 0.00045 20.3 0.0 0.00083 19.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain FeoB_N PF02421.13 KOO27678.1 - 0.00065 19.0 0.1 0.0044 16.2 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA PF00004.24 KOO27678.1 - 0.0035 17.5 0.2 0.48 10.6 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KOO27678.1 - 0.0074 16.0 0.0 0.016 14.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF258 PF03193.11 KOO27678.1 - 0.0075 15.4 0.0 0.017 14.3 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 KOO27678.1 - 0.008 16.4 0.1 0.013 15.7 0.1 1.6 1 1 0 1 1 1 1 ABC transporter AAA_16 PF13191.1 KOO27678.1 - 0.041 13.8 0.1 0.093 12.7 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Septin PF00735.13 KOO27678.1 - 0.057 12.4 0.1 0.23 10.4 0.0 1.9 2 0 0 2 2 2 0 Septin AAA_29 PF13555.1 KOO27678.1 - 0.065 12.7 0.5 0.32 10.5 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_14 PF13173.1 KOO27678.1 - 0.07 13.0 0.1 0.16 11.8 0.1 1.8 1 1 0 1 1 1 0 AAA domain Glyco_hydro_32N PF00251.15 KOO27678.1 - 0.1 11.9 0.1 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 32 N-terminal domain DUF1643 PF07799.7 KOO27678.1 - 0.12 12.0 0.1 0.16 11.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1643) Ank_2 PF12796.2 KOO27679.1 - 8e-25 87.0 1.3 8.5e-14 51.6 0.1 3.6 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) NCA2 PF08637.5 KOO27679.1 - 1.2e-18 66.9 0.2 2.3e-11 43.1 0.1 2.3 2 0 0 2 2 2 2 ATP synthase regulation protein NCA2 Ank PF00023.25 KOO27679.1 - 3.6e-10 39.1 10.3 4e-09 35.8 0.1 4.9 6 0 0 6 6 6 1 Ankyrin repeat Ank_4 PF13637.1 KOO27679.1 - 4.3e-10 39.8 0.1 0.00065 20.1 0.1 4.6 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO27679.1 - 1e-09 38.3 0.5 3.5e-07 30.2 0.1 3.6 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO27679.1 - 1.3e-05 24.9 4.5 0.0023 17.9 0.1 4.8 5 0 0 5 5 5 1 Ankyrin repeat LUC7 PF03194.10 KOO27680.1 - 5.9 6.3 9.0 3 7.2 1.7 2.1 2 0 0 2 2 2 0 LUC7 N_terminus IncA PF04156.9 KOO27680.1 - 9.7 5.7 13.6 4 6.9 3.5 2.3 2 0 0 2 2 2 0 IncA protein 5_3_exonuc_N PF02739.11 KOO27681.1 - 4.1e-33 114.1 0.0 5.4e-33 113.7 0.0 1.2 1 0 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain 5_3_exonuc PF01367.15 KOO27681.1 - 8.5e-24 83.7 0.0 1.3e-23 83.0 0.0 1.3 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold NYN_YacP PF05991.6 KOO27681.1 - 0.024 14.3 0.0 0.044 13.5 0.0 1.3 1 0 0 1 1 1 0 YacP-like NYN domain HHH_2 PF12826.2 KOO27681.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif Guanylate_kin PF00625.16 KOO27682.1 - 9e-62 207.7 0.0 1.1e-61 207.4 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.1 KOO27682.1 - 6.4e-06 26.1 0.0 3.4e-05 23.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 KOO27682.1 - 2.9e-05 23.3 0.0 4.8e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 KOO27682.1 - 0.00033 20.7 0.0 0.0031 17.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KOO27682.1 - 0.0026 17.7 0.0 0.0059 16.6 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.1 KOO27682.1 - 0.0033 17.7 0.2 0.048 13.9 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO27682.1 - 0.0055 17.5 0.1 0.0088 16.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain Miro PF08477.8 KOO27682.1 - 0.018 15.5 0.0 0.042 14.3 0.0 1.7 1 1 0 1 1 1 0 Miro-like protein Methyltransf_12 PF08242.7 KOO27682.1 - 0.034 14.5 0.0 4 7.9 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Arch_ATPase PF01637.13 KOO27682.1 - 0.062 12.9 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase Fimbrillin_C PF15495.1 KOO27682.1 - 0.066 13.3 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Major fimbrial subunit protein type IV, Fimbrillin, C-terminal ABC_tran PF00005.22 KOO27682.1 - 0.071 13.4 0.0 0.09 13.0 0.0 1.4 1 1 0 1 1 1 0 ABC transporter AAA_14 PF13173.1 KOO27682.1 - 0.079 12.8 0.0 0.2 11.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.18 KOO27682.1 - 0.097 12.6 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase MobB PF03205.9 KOO27682.1 - 0.15 11.7 0.0 0.83 9.3 0.0 2.1 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DUF1895 PF08988.5 KOO27682.1 - 0.16 12.0 0.1 0.42 10.6 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1895) Ppx-GppA PF02541.11 KOO27683.1 - 9.4e-13 47.9 0.0 1.5e-12 47.3 0.0 1.2 1 0 0 1 1 1 1 Ppx/GppA phosphatase family FtsA PF14450.1 KOO27683.1 - 0.078 12.8 0.1 1.5 8.6 0.0 2.5 3 0 0 3 3 3 0 Cell division protein FtsA DUF1049 PF06305.6 KOO27683.1 - 0.12 11.8 0.8 0.33 10.4 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) SPW PF03779.9 KOO27683.1 - 0.27 10.6 4.0 0.14 11.5 0.3 2.4 2 0 0 2 2 2 0 SPW repeat Voltage_CLC PF00654.15 KOO27684.1 - 7.3e-64 216.0 13.2 7.3e-64 216.0 9.1 2.0 2 1 0 2 2 2 1 Voltage gated chloride channel SNARE_assoc PF09335.6 KOO27684.1 - 9.2e-12 45.2 6.8 9.2e-12 45.2 4.7 4.3 4 0 0 4 4 4 1 SNARE associated Golgi protein CBS PF00571.23 KOO27684.1 - 8.7e-11 41.4 5.9 1.9e-05 24.3 0.2 3.6 4 0 0 4 4 4 2 CBS domain BLUF PF04940.7 KOO27684.1 - 0.014 15.1 0.0 0.03 14.0 0.0 1.5 1 0 0 1 1 1 0 Sensors of blue-light using FAD SAP PF02037.22 KOO27685.1 - 3.3e-08 32.8 0.6 9.6e-08 31.3 0.4 1.9 1 0 0 1 1 1 1 SAP domain LRR_6 PF13516.1 KOO27685.1 - 3.8e-07 29.5 3.6 0.012 15.5 0.0 3.9 3 1 0 3 3 3 2 Leucine Rich repeat GAS2 PF02187.12 KOO27686.1 - 0.00095 18.8 0.0 0.0016 18.1 0.0 1.4 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain Flg_hook PF02120.11 KOO27686.1 - 0.095 12.3 1.2 1.5 8.5 0.0 2.9 3 0 0 3 3 3 0 Flagellar hook-length control protein FliK PAT1 PF09770.4 KOO27686.1 - 1.1 7.3 10.8 1.2 7.2 7.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 His_Phos_2 PF00328.17 KOO27689.1 - 3.9e-57 194.1 0.3 1.7e-33 116.4 0.0 2.2 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) RimK PF08443.6 KOO27689.1 - 0.00024 20.6 0.0 0.00048 19.6 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain His_Phos_1 PF00300.17 KOO27689.1 - 0.0014 18.7 0.7 0.14 12.2 0.2 3.2 3 1 0 3 3 3 1 Histidine phosphatase superfamily (branch 1) Sulfotransfer_2 PF03567.9 KOO27690.1 - 1.6e-10 41.1 0.0 3.3e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 Sulfotransferase family CDC73 PF05179.9 KOO27691.1 - 1.3e-38 132.9 0.1 3.5e-38 131.5 0.0 1.4 1 1 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family EF-hand_1 PF00036.27 KOO27692.1 - 2.2e-08 32.8 0.0 0.00052 19.1 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO27692.1 - 4.7e-08 32.0 0.7 0.00077 18.6 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO27692.1 - 2.4e-06 26.9 0.0 0.023 14.5 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO27692.1 - 2.1e-05 24.5 0.0 0.071 13.2 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO27692.1 - 3.3e-05 23.4 0.0 0.15 11.7 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair Rossmann-like PF10727.4 KOO27692.1 - 0.071 12.8 1.6 0.093 12.4 1.0 1.4 1 1 0 1 1 1 0 Rossmann-like domain MAPEG PF01124.13 KOO27694.1 - 2.8e-06 26.9 0.6 2.8e-06 26.9 0.4 1.8 2 0 0 2 2 2 1 MAPEG family Vps26 PF03643.10 KOO27695.1 - 3.7e-42 144.0 0.0 5.1e-42 143.5 0.0 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.24 KOO27695.1 - 2.3e-07 30.7 0.0 2e-06 27.7 0.0 2.2 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain DUF1528 PF07515.6 KOO27696.1 - 0.055 13.5 0.0 0.098 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1528) Ion_trans PF00520.26 KOO27697.1 - 2e-82 275.3 63.5 2.5e-40 137.8 5.1 5.1 6 0 0 6 6 6 4 Ion transport protein DUF1680 PF07944.7 KOO27697.1 - 2.6e-14 52.3 0.0 8.4e-14 50.7 0.0 1.7 1 1 1 2 2 2 1 Putative glycosyl hydrolase of unknown function (DUF1680) PKD_channel PF08016.7 KOO27697.1 - 3.4e-05 22.4 24.2 0.00015 20.3 3.3 5.7 6 0 0 6 6 6 2 Polycystin cation channel EF-hand_1 PF00036.27 KOO27697.1 - 0.029 13.6 0.1 0.092 12.0 0.0 2.0 1 0 0 1 1 1 0 EF hand MORN PF02493.15 KOO27698.1 - 4.5e-43 142.4 44.0 5.5e-07 28.9 0.3 9.2 9 0 0 9 9 9 8 MORN repeat DUF4359 PF14271.1 KOO27698.1 - 0.18 12.1 2.1 7.2 7.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4359) SM-ATX PF14438.1 KOO27698.1 - 1.1 9.2 5.1 25 4.8 0.1 3.8 4 0 0 4 4 4 0 Ataxin 2 SM domain p25-alpha PF05517.7 KOO27700.1 - 0.00095 19.4 2.0 0.00095 19.4 1.4 8.6 10 0 0 10 10 10 2 p25-alpha DUF760 PF05542.6 KOO27701.1 - 4.2e-34 116.5 1.0 9e-18 64.2 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF760) 2OG-FeII_Oxy_3 PF13640.1 KOO27702.1 - 9e-13 48.5 0.2 3.8e-12 46.5 0.0 1.9 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO27702.1 - 8.3e-05 22.1 0.4 0.0002 20.9 0.3 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Fe-ADH PF00465.14 KOO27702.1 - 0.11 11.1 0.1 0.13 10.8 0.1 1.1 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase GTP_EFTU PF00009.22 KOO27703.1 - 1.8e-50 170.9 0.3 2.7e-50 170.4 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.19 KOO27703.1 - 4.8e-19 68.0 0.0 9.4e-19 67.0 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.18 KOO27703.1 - 1.8e-06 27.8 0.2 3.8e-06 26.8 0.2 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.20 KOO27703.1 - 8.6e-06 25.7 0.0 3.3e-05 23.9 0.0 2.1 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Septin PF00735.13 KOO27703.1 - 8.9e-05 21.6 0.1 0.00014 21.0 0.1 1.2 1 0 0 1 1 1 1 Septin Miro PF08477.8 KOO27703.1 - 0.00016 22.1 0.0 0.00028 21.3 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein FeoB_N PF02421.13 KOO27703.1 - 0.00019 20.7 0.1 0.011 14.9 0.1 2.7 2 1 0 2 2 2 1 Ferrous iron transport protein B Arf PF00025.16 KOO27703.1 - 0.0013 18.0 0.0 0.0033 16.6 0.0 1.6 2 0 0 2 2 2 1 ADP-ribosylation factor family Dynamin_N PF00350.18 KOO27703.1 - 0.004 16.9 0.0 0.56 9.9 0.0 2.2 1 1 1 2 2 2 1 Dynamin family SRPRB PF09439.5 KOO27703.1 - 0.018 14.2 0.1 0.076 12.2 0.1 2.0 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit EFG_II PF14492.1 KOO27703.1 - 0.027 14.3 0.0 0.057 13.2 0.0 1.5 1 0 0 1 1 1 0 Elongation Factor G, domain II SAP PF02037.22 KOO27704.1 - 2.8e-08 33.0 3.0 3.2e-05 23.2 0.1 2.7 3 0 0 3 3 3 2 SAP domain HeH PF12949.2 KOO27704.1 - 0.0021 17.5 0.4 0.097 12.2 0.1 2.6 2 0 0 2 2 2 1 HeH/LEM domain XPC-binding PF09280.6 KOO27704.1 - 1.1 8.7 3.9 4 6.9 2.3 2.1 1 1 1 2 2 2 0 XPC-binding domain 4HBT PF03061.17 KOO27706.1 - 0.00016 21.7 0.0 0.00034 20.6 0.0 1.5 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.1 KOO27706.1 - 0.0059 16.3 0.1 0.0071 16.1 0.1 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily LRR_6 PF13516.1 KOO27707.1 - 5e-26 87.8 26.9 0.0067 16.3 0.0 15.9 17 0 0 17 17 17 5 Leucine Rich repeat Ank_2 PF12796.2 KOO27707.1 - 6.6e-18 64.8 1.1 4e-09 36.6 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO27707.1 - 9e-14 51.1 1.0 1.7e-07 31.2 0.1 3.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) LRR_1 PF00560.28 KOO27707.1 - 6.6e-12 43.7 5.8 39 4.8 0.0 12.5 14 0 0 14 14 14 0 Leucine Rich Repeat Ank_4 PF13637.1 KOO27707.1 - 1.3e-11 44.6 0.2 0.00031 21.1 0.0 3.5 3 0 0 3 3 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO27707.1 - 3.8e-10 39.0 0.3 5.9e-06 26.0 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.25 KOO27707.1 - 4.3e-10 38.8 7.4 0.0001 21.9 0.0 4.6 5 0 0 5 5 5 2 Ankyrin repeat LRR_4 PF12799.2 KOO27707.1 - 5e-08 32.3 8.9 3.6 7.3 0.0 9.4 8 3 2 10 10 10 1 Leucine Rich repeats (2 copies) Skp1 PF01466.14 KOO27707.1 - 0.0001 22.2 0.0 0.00033 20.6 0.0 1.8 1 0 0 1 1 1 1 Skp1 family, dimerisation domain LRR_8 PF13855.1 KOO27707.1 - 0.58 9.9 20.4 1.5 8.6 0.9 8.1 6 3 3 9 9 9 0 Leucine rich repeat LRR_7 PF13504.1 KOO27707.1 - 0.85 10.0 19.0 1.5e+02 3.3 0.0 10.1 12 0 0 12 12 11 0 Leucine rich repeat Dispanin PF04505.7 KOO27707.1 - 2.9 7.5 7.2 12 5.4 0.1 3.8 4 0 0 4 4 4 0 Interferon-induced transmembrane protein NYN PF01936.13 KOO27708.1 - 5.3e-11 42.9 0.0 8e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 NYN domain PAP_fibrillin PF04755.7 KOO27709.1 - 6.4e-08 32.5 0.0 2.8e-07 30.4 0.0 2.1 2 0 0 2 2 2 1 PAP_fibrillin FAM117 PF15388.1 KOO27711.1 - 0.12 11.5 0.1 0.13 11.4 0.1 1.1 1 0 0 1 1 1 0 Protein Family FAM117 HlyD PF00529.15 KOO27711.1 - 0.26 10.5 22.6 0.31 10.3 15.6 1.1 1 0 0 1 1 1 0 HlyD family secretion protein PAT1 PF09770.4 KOO27711.1 - 0.39 8.9 5.0 0.44 8.7 3.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Vfa1 PF08432.5 KOO27711.1 - 0.43 10.5 5.4 0.54 10.2 3.8 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF1501 PF07394.7 KOO27711.1 - 0.9 8.3 7.1 1 8.1 4.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) RIB43A PF05914.7 KOO27711.1 - 1.3 7.5 10.6 1.6 7.2 7.4 1.1 1 0 0 1 1 1 0 RIB43A Kinesin PF00225.18 KOO27712.1 - 4.7e-81 272.0 0.0 8.1e-81 271.3 0.0 1.3 1 1 0 1 1 1 1 Kinesin motor domain DUF4554 PF15091.1 KOO27713.1 - 0.14 10.8 0.6 0.18 10.5 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Borrelia_P83 PF05262.6 KOO27713.1 - 0.5 8.5 8.4 0.65 8.2 5.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF1995 PF09353.5 KOO27714.1 - 0.0033 17.0 0.1 0.0038 16.8 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1995) HEAT_EZ PF13513.1 KOO27714.1 - 8.4 7.0 13.4 0.32 11.5 0.7 3.6 3 1 1 4 4 4 0 HEAT-like repeat Dynein_heavy PF03028.10 KOO27715.1 - 1.6e-29 102.5 0.0 1.7e-29 102.3 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor Helicase_C PF00271.26 KOO27717.1 - 2.3e-10 40.2 0.0 3.8e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SUV3_C PF12513.3 KOO27717.1 - 2.5e-10 39.6 0.3 6.3e-10 38.3 0.2 1.8 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal DUF4386 PF14329.1 KOO27718.1 - 0.002 17.6 5.4 0.002 17.6 3.7 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4386) COX8 PF02285.10 KOO27718.1 - 0.008 15.6 0.4 0.96 9.0 0.1 2.5 2 0 0 2 2 2 2 Cytochrome oxidase c subunit VIII UNC-93 PF05978.11 KOO27718.1 - 0.097 12.1 0.1 0.097 12.1 0.1 1.6 2 0 0 2 2 2 0 Ion channel regulatory protein UNC-93 XRN_N PF03159.13 KOO27720.1 - 6.9e-66 222.0 0.0 1e-65 221.4 0.0 1.2 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus LRR_6 PF13516.1 KOO27720.1 - 7.8e-28 93.3 20.9 0.019 14.9 0.0 14.6 15 0 0 15 15 15 6 Leucine Rich repeat LRR_1 PF00560.28 KOO27720.1 - 2.1e-10 39.1 0.6 10 6.5 0.0 9.8 11 0 0 11 11 11 1 Leucine Rich Repeat LRR_4 PF12799.2 KOO27720.1 - 3.1e-06 26.6 17.4 1.7 8.3 0.0 8.5 6 3 2 9 9 9 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO27720.1 - 5.4e-06 26.0 12.7 0.36 10.5 0.1 7.5 6 3 1 7 7 7 2 Leucine rich repeat LRR_7 PF13504.1 KOO27720.1 - 0.0063 16.5 17.1 22 5.8 0.2 9.4 11 0 0 11 11 11 1 Leucine rich repeat PALP PF00291.20 KOO27721.1 - 4.9e-11 42.4 0.1 5.4e-11 42.2 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Peptidase_M1 PF01433.15 KOO27722.1 - 2.4e-36 125.6 0.0 2.9e-36 125.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 TPR_16 PF13432.1 KOO27723.1 - 3e-15 56.4 13.3 0.017 15.7 0.6 7.8 6 2 2 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.1 KOO27723.1 - 7.3e-15 54.3 23.6 3.9e-05 23.2 2.9 7.6 6 2 3 9 9 9 4 TPR repeat TPR_19 PF14559.1 KOO27723.1 - 5.2e-13 49.1 14.0 0.0015 18.8 0.1 5.9 4 1 1 5 5 5 3 Tetratricopeptide repeat Apc3 PF12895.2 KOO27723.1 - 1.9e-11 43.9 20.1 0.0016 18.5 0.1 6.5 4 2 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.12 KOO27723.1 - 5e-09 35.4 30.0 0.032 14.1 0.1 10.5 11 0 0 11 11 11 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOO27723.1 - 6.7e-09 35.5 17.2 0.11 12.4 0.0 8.0 6 2 4 10 10 10 4 Tetratricopeptide repeat TPR_1 PF00515.23 KOO27723.1 - 3.7e-07 29.4 30.6 0.13 11.9 0.4 8.9 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_14 PF13428.1 KOO27723.1 - 1.9e-06 27.9 9.4 0.32 11.7 0.1 8.6 4 2 5 9 9 9 1 Tetratricopeptide repeat TPR_18 PF13512.1 KOO27723.1 - 0.0047 16.9 3.0 0.028 14.4 1.4 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO27723.1 - 0.32 10.8 20.5 4 7.4 0.1 7.2 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO27723.1 - 0.36 10.7 5.2 27 4.6 0.0 4.3 5 1 0 5 5 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO27723.1 - 0.37 10.6 21.0 4.3 7.3 0.0 7.9 10 0 0 10 10 10 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO27723.1 - 0.38 11.3 27.5 2.3 8.8 0.5 8.3 10 0 0 10 10 9 0 Tetratricopeptide repeat PPR_3 PF13812.1 KOO27723.1 - 1.1 9.6 5.7 13 6.3 0.1 4.9 4 0 0 4 4 4 0 Pentatricopeptide repeat domain NAD_binding_10 PF13460.1 KOO27724.1 - 1.1e-05 25.4 0.8 0.00014 21.9 0.0 2.6 2 1 0 2 2 2 1 NADH(P)-binding DUF342 PF03961.8 KOO27724.1 - 0.022 13.1 0.0 0.027 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) IFR3_antag PF14754.1 KOO27724.1 - 0.066 12.1 0.0 0.17 10.8 0.0 1.6 1 0 0 1 1 1 0 Papain-like auto-proteinase APG6 PF04111.7 KOO27724.1 - 5.8 5.8 9.0 8.4 5.3 6.3 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Ank_2 PF12796.2 KOO27726.1 - 4.2e-19 68.6 2.4 7.2e-10 39.0 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO27726.1 - 2.5e-16 59.2 8.6 3.9e-09 36.4 0.5 4.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO27726.1 - 2.5e-15 56.4 3.2 7.1e-05 23.2 0.0 5.0 4 1 2 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.25 KOO27726.1 - 4.5e-15 54.6 9.7 2.8e-05 23.7 0.1 5.8 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.1 KOO27726.1 - 2.3e-07 30.3 3.3 0.1 12.8 0.0 4.8 4 0 0 4 4 4 2 Ankyrin repeat Prefoldin_2 PF01920.15 KOO27726.1 - 0.28 10.9 0.6 13 5.6 0.1 2.2 2 0 0 2 2 2 0 Prefoldin subunit Adaptin_N PF01602.15 KOO27728.1 - 8.2e-108 361.0 3.1 1e-107 360.7 2.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 KOO27728.1 - 2.9e-12 46.6 6.4 4.3e-06 26.9 0.1 5.5 3 2 3 6 6 6 4 HEAT repeats HEAT PF02985.17 KOO27728.1 - 1.2e-10 40.4 1.2 0.24 11.5 0.0 5.7 5 0 0 5 5 5 3 HEAT repeat Cnd1 PF12717.2 KOO27728.1 - 2.3e-09 37.3 4.8 7.9e-08 32.3 0.9 3.5 2 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Proteasom_PSMB PF10508.4 KOO27728.1 - 6.5e-05 21.3 1.8 6.5e-05 21.3 1.3 1.8 2 1 0 2 2 2 1 Proteasome non-ATPase 26S subunit HEAT_EZ PF13513.1 KOO27728.1 - 0.00025 21.4 8.0 1.9 9.0 0.0 6.3 6 1 1 7 7 7 1 HEAT-like repeat CLASP_N PF12348.3 KOO27728.1 - 0.026 13.9 0.3 1.7 7.9 0.0 3.3 2 1 1 3 3 3 0 CLASP N terminal Arm PF00514.18 KOO27728.1 - 0.07 12.9 1.6 0.82 9.5 0.2 3.1 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat DUF2435 PF10363.4 KOO27728.1 - 0.081 12.8 4.0 1.9 8.4 0.1 3.7 4 1 0 4 4 4 0 Protein of unknown function (DUF2435) XRN_N PF03159.13 KOO27730.1 - 1.3e-93 312.7 0.0 2.1e-93 312.0 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus Pro_isomerase PF00160.16 KOO27731.1 - 4.7e-45 153.5 0.0 5.5e-45 153.3 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Cystatin PF00031.16 KOO27732.1 - 3.2 7.9 6.8 0.31 11.1 0.7 2.3 3 0 0 3 3 3 0 Cystatin domain GTPase_Cys_C PF12631.2 KOO27733.1 - 2.2 8.7 4.9 34 4.9 0.5 2.8 3 0 0 3 3 3 0 Catalytic cysteine-containing C-terminus of GTPase, MnmE DUF1018 PF06252.7 KOO27734.1 - 0.0076 16.7 0.1 0.13 12.7 0.6 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF1018) DUF2389 PF09493.5 KOO27735.1 - 0.089 13.0 0.1 4.2 7.7 0.0 2.5 2 0 0 2 2 2 0 Tryptophan-rich protein (DUF2389) PDZ PF00595.19 KOO27736.1 - 9.2e-14 51.3 0.0 4.8e-08 33.0 0.0 2.5 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) WW PF00397.21 KOO27736.1 - 1.5e-08 34.3 0.7 8.7e-05 22.2 0.0 2.6 2 0 0 2 2 2 2 WW domain PDZ_2 PF13180.1 KOO27736.1 - 2.1e-08 33.9 0.1 3.1e-05 23.7 0.0 2.5 2 0 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.1 KOO27736.1 - 5.3e-05 22.9 0.0 0.097 12.4 0.0 2.5 2 0 0 2 2 2 2 Tricorn protease PDZ domain DnaJ PF00226.26 KOO27737.1 - 4.6e-18 64.7 0.1 4.6e-18 64.7 0.0 2.3 2 0 0 2 2 2 1 DnaJ domain Myb_DNA-binding PF00249.26 KOO27737.1 - 3.8e-12 46.0 0.3 9.6e-06 25.5 0.1 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO27737.1 - 4.2e-06 26.7 0.1 0.019 15.0 0.0 3.0 3 0 0 3 3 3 2 Myb-like DNA-binding domain VPS11_C PF12451.3 KOO27738.1 - 1.3e-06 28.1 0.0 2.4e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal Clathrin PF00637.15 KOO27738.1 - 0.01 15.4 0.0 0.031 13.8 0.0 1.8 2 0 0 2 2 2 0 Region in Clathrin and VPS zf-C3HC4_2 PF13923.1 KOO27738.1 - 0.064 13.2 8.6 0.18 11.8 5.9 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO27738.1 - 0.11 12.3 10.9 0.26 11.1 7.6 1.7 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.1 KOO27738.1 - 0.16 11.7 8.8 0.39 10.4 6.1 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.20 KOO27738.1 - 1.9 8.2 9.0 4.2 7.1 6.3 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Chorismate_synt PF01264.16 KOO27741.1 - 3e-121 404.1 0.0 6.1e-63 212.3 0.0 2.1 2 0 0 2 2 2 2 Chorismate synthase MORN PF02493.15 KOO27742.1 - 7.2e-12 44.3 13.0 1.1e-06 28.0 1.2 3.7 3 0 0 3 3 3 3 MORN repeat LRR_6 PF13516.1 KOO27742.1 - 4.5e-06 26.1 0.7 0.027 14.4 0.0 3.4 3 0 0 3 3 3 2 Leucine Rich repeat HALZ PF02183.13 KOO27742.1 - 0.042 13.5 0.3 0.085 12.5 0.2 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper DUF972 PF06156.8 KOO27742.1 - 0.56 10.5 1.8 1.9 8.8 1.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF972) CDC45 PF02724.9 KOO27745.1 - 2.3e-120 402.5 0.1 8e-118 394.1 0.1 2.8 1 1 0 1 1 1 1 CDC45-like protein Sld5 PF05916.6 KOO27746.1 - 1.7e-17 63.6 0.1 2.5e-17 63.1 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein Serine_rich PF08824.5 KOO27746.1 - 0.063 12.9 0.0 0.094 12.4 0.0 1.2 1 0 0 1 1 1 0 Serine rich protein interaction domain PLDc_2 PF13091.1 KOO27747.1 - 5.8e-23 81.0 0.0 1.5e-13 50.5 0.0 2.2 2 0 0 2 2 2 2 PLD-like domain PLDc_3 PF13918.1 KOO27747.1 - 2.7e-19 69.2 0.0 8.2e-15 54.6 0.0 3.3 3 0 0 3 3 3 2 PLD-like domain PLDc PF00614.17 KOO27747.1 - 1.7e-05 24.4 1.0 0.0011 18.6 0.0 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif Ndufs5 PF10200.4 KOO27749.1 - 0.032 14.2 0.2 0.071 13.1 0.1 1.5 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa MMR_HSR1 PF01926.18 KOO27750.1 - 4.4e-19 68.5 0.0 7.3e-19 67.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP1_OBG PF01018.17 KOO27750.1 - 7e-13 48.5 8.2 1.8e-06 27.6 1.1 3.2 2 2 0 2 2 2 2 GTP1/OBG GTP_EFTU PF00009.22 KOO27750.1 - 2.2e-05 24.0 0.0 0.014 14.8 0.0 2.2 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 KOO27750.1 - 0.00019 21.3 0.0 0.049 13.4 0.0 2.2 1 1 1 2 2 2 2 Dynamin family FeoB_N PF02421.13 KOO27750.1 - 0.00031 20.0 0.0 0.0051 16.0 0.0 2.6 2 1 0 2 2 2 1 Ferrous iron transport protein B ATP_bind_1 PF03029.12 KOO27750.1 - 0.0018 17.8 0.0 0.14 11.7 0.0 2.1 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein ArgK PF03308.11 KOO27750.1 - 0.043 12.5 0.1 0.56 8.9 0.0 2.2 2 0 0 2 2 2 0 ArgK protein Arf PF00025.16 KOO27750.1 - 0.17 11.0 0.0 19 4.4 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family IQ PF00612.22 KOO27752.1 - 0.0026 17.2 1.4 0.0036 16.7 0.1 1.9 2 0 0 2 2 2 1 IQ calmodulin-binding motif Redoxin PF08534.5 KOO27753.1 - 8.6e-07 28.6 0.0 1.7e-06 27.6 0.0 1.5 1 1 0 1 1 1 1 Redoxin Nuc_sug_transp PF04142.10 KOO27754.1 - 2.1e-24 85.9 3.5 2.6e-24 85.6 2.5 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.15 KOO27754.1 - 0.0008 19.4 4.5 0.0008 19.4 3.1 2.6 2 1 0 2 2 2 1 EamA-like transporter family DASH_Dad2 PF08654.5 KOO27755.1 - 0.29 11.1 0.2 0.29 11.1 0.1 3.4 3 1 0 3 3 3 0 DASH complex subunit Dad2 Ly49 PF08391.5 KOO27755.1 - 2.5 8.2 9.6 4.5 7.4 0.9 3.1 3 0 0 3 3 3 0 Ly49-like protein, N-terminal region WD40 PF00400.27 KOO27756.1 - 7.1e-25 85.9 5.2 0.00021 21.0 0.2 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat MFS_1 PF07690.11 KOO27758.1 - 1.6e-33 115.9 34.3 1.6e-33 115.9 23.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF754 PF05449.6 KOO27758.1 - 3.6 7.6 8.4 0.31 11.0 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF754) PA28_beta PF02252.13 KOO27760.1 - 9.4e-25 86.8 0.1 9.7e-14 51.0 0.0 2.1 1 1 1 2 2 2 2 Proteasome activator pa28 beta subunit Tir_receptor_N PF07490.6 KOO27760.1 - 0.0014 18.3 1.4 0.0025 17.4 1.0 1.4 1 0 0 1 1 1 1 Translocated intimin receptor (Tir) N-terminus Pox_RNA_Pol_19 PF05320.7 KOO27760.1 - 0.69 9.6 6.6 0.37 10.5 3.0 1.6 2 0 0 2 2 2 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Ion_trans PF00520.26 KOO27762.1 - 4.8e-08 32.4 14.9 4.8e-08 32.4 10.4 1.8 2 1 0 2 2 2 1 Ion transport protein PKD_channel PF08016.7 KOO27762.1 - 5.2e-06 25.1 10.2 9.5e-06 24.2 7.1 1.4 1 1 0 1 1 1 1 Polycystin cation channel EF-hand_6 PF13405.1 KOO27762.1 - 0.00027 20.5 0.1 0.0012 18.4 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 KOO27762.1 - 0.0011 18.1 0.0 0.0038 16.4 0.0 2.0 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO27762.1 - 0.0055 16.8 0.0 0.013 15.6 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO27762.1 - 0.076 12.3 0.1 0.21 10.9 0.0 1.8 1 0 0 1 1 1 0 EF hand ADH_zinc_N_2 PF13602.1 KOO27763.1 - 9.5e-23 81.4 0.0 2.1e-22 80.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 KOO27763.1 - 5.8e-14 51.7 0.0 1.3e-13 50.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOO27763.1 - 1.1e-07 31.5 0.4 2.5e-06 27.1 0.1 2.7 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain Eno-Rase_NADH_b PF12242.3 KOO27763.1 - 0.041 13.6 1.3 0.11 12.3 0.9 1.7 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DapB_N PF01113.15 KOO27763.1 - 0.044 13.7 0.1 0.081 12.8 0.1 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus EF-hand_1 PF00036.27 KOO27765.1 - 1.1e-08 33.7 0.1 0.00013 21.0 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO27765.1 - 2.3e-06 26.6 0.1 0.031 13.6 0.2 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO27765.1 - 5.3e-06 25.8 0.1 0.027 14.3 0.1 2.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO27765.1 - 9.6e-06 25.6 0.1 1.4e-05 25.1 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO27765.1 - 1.2e-05 24.8 0.2 0.11 12.0 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair Glycophorin_A PF01102.13 KOO27767.1 - 0.02 14.6 1.2 0.06 13.1 0.8 1.8 1 1 0 1 1 1 0 Glycophorin A EphA2_TM PF14575.1 KOO27767.1 - 0.18 12.1 1.5 0.43 11.0 0.0 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.15 KOO27767.1 - 5.6 6.6 6.5 0.55 9.9 0.1 2.3 2 1 0 2 2 2 0 Syndecan domain DUF3984 PF13136.1 KOO27768.1 - 0.053 12.7 0.1 0.061 12.5 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) PABP PF00658.13 KOO27770.1 - 2.2e-15 56.0 0.1 4.3e-15 55.1 0.0 1.5 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RNA_GG_bind PF10258.4 KOO27770.1 - 1.4e-11 43.9 0.0 2.4e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 PHAX RNA-binding domain DUF1180 PF06679.7 KOO27770.1 - 1.1 9.1 4.1 0.41 10.5 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Glutaredoxin PF00462.19 KOO27771.1 - 9.9e-06 25.4 0.0 2.2e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.1 KOO27771.1 - 0.11 12.7 0.0 0.5 10.6 0.0 2.1 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain Gly_transf_sug PF04488.10 KOO27772.1 - 6.2e-14 52.2 0.0 9.1e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.7 KOO27772.1 - 0.0009 18.4 0.0 0.001 18.3 0.0 1.1 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein TcdA_TcdB PF12919.2 KOO27772.1 - 0.016 13.7 0.0 0.019 13.4 0.0 1.1 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain DUF570 PF04489.8 KOO27773.1 - 0.26 9.6 0.1 0.43 8.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF570) Tetraspannin PF00335.15 KOO27775.1 - 7.6e-08 31.9 3.3 7.6e-08 31.9 2.3 3.4 1 1 1 3 3 3 3 Tetraspanin family MLANA PF14991.1 KOO27775.1 - 0.054 13.5 0.1 0.32 11.0 0.0 2.3 2 0 0 2 2 2 0 Protein melan-A Clat_adaptor_s PF01217.15 KOO27776.1 - 7.5e-48 161.8 2.2 8.4e-48 161.6 1.6 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain SBBP PF06739.6 KOO27777.1 - 2.9e-10 39.7 33.1 0.0025 17.5 0.4 6.3 6 0 0 6 6 6 5 Beta-propeller repeat Trypsin_2 PF13365.1 KOO27777.1 - 4.8e-05 23.3 0.0 0.00022 21.2 0.0 2.2 1 1 0 1 1 1 1 Trypsin-like peptidase domain NMU PF02070.10 KOO27777.1 - 2.9 7.4 5.3 99 2.5 0.0 4.3 4 0 0 4 4 4 0 Neuromedin U SBBP PF06739.6 KOO27778.1 - 2e-12 46.6 34.0 0.0011 18.7 0.4 6.1 6 0 0 6 6 6 5 Beta-propeller repeat NMU PF02070.10 KOO27778.1 - 0.0014 18.1 3.8 30 4.2 0.0 5.5 5 0 0 5 5 5 4 Neuromedin U DUF1253 PF06862.7 KOO27781.1 - 8.9e-43 146.3 0.0 9.5e-43 146.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1253) RNase_Zc3h12a PF11977.3 KOO27782.1 - 1.8e-06 27.8 0.0 2.7e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain IpaB_EvcA PF03278.8 KOO27783.1 - 0.0085 15.3 0.3 3.1 7.0 0.0 2.2 2 0 0 2 2 2 2 IpaB/EvcA family C_GCAxxG_C_C PF09719.5 KOO27783.1 - 0.3 10.9 3.4 0.9 9.3 0.4 2.6 2 0 0 2 2 2 0 Putative redox-active protein (C_GCAxxG_C_C) Ion_trans_2 PF07885.11 KOO27784.1 - 3.4e-22 77.9 15.7 8e-11 41.5 5.6 2.3 2 0 0 2 2 2 2 Ion channel EF-hand_1 PF00036.27 KOO27784.1 - 0.0083 15.3 1.3 0.02 14.1 0.0 2.3 2 0 0 2 2 2 1 EF hand Ion_trans PF00520.26 KOO27784.1 - 0.019 14.1 8.7 0.022 14.0 1.9 2.3 2 0 0 2 2 2 0 Ion transport protein EF-hand_5 PF13202.1 KOO27784.1 - 0.026 13.8 0.2 0.026 13.8 0.1 1.8 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.1 KOO27784.1 - 0.043 13.6 1.9 0.05 13.5 0.1 2.1 2 0 0 2 2 2 0 EF-hand domain DUF21 PF01595.15 KOO27784.1 - 0.058 12.6 1.4 0.11 11.7 0.9 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF21 YGGT PF02325.12 KOO27784.1 - 0.067 13.1 0.4 0.18 11.7 0.3 1.7 1 0 0 1 1 1 0 YGGT family EF-hand_7 PF13499.1 KOO27784.1 - 0.1 12.7 0.0 0.3 11.2 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair Reo_sigmaC PF04582.7 KOO27787.1 - 8.8 5.3 16.2 11 5.0 0.2 5.4 3 2 1 6 6 6 0 Reovirus sigma C capsid protein Orn_Arg_deC_N PF02784.11 KOO27789.1 - 2.3e-39 135.1 0.0 3.5e-39 134.5 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain NUDIX PF00293.23 KOO27789.1 - 7e-10 38.6 0.0 2.2e-09 37.0 0.0 1.8 1 0 0 1 1 1 1 NUDIX domain Peptidase_S41 PF03572.13 KOO27789.1 - 0.17 11.2 0.0 0.33 10.3 0.0 1.4 1 0 0 1 1 1 0 Peptidase family S41 DUF3518 PF12031.3 KOO27790.1 - 0.007 15.2 0.0 0.012 14.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3518) Arm PF00514.18 KOO27790.1 - 0.0084 15.9 1.3 0.74 9.7 0.0 3.4 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat MR_MLE_C PF13378.1 KOO27790.1 - 0.12 12.3 1.4 0.24 11.4 0.2 2.0 1 1 1 2 2 2 0 Enolase C-terminal domain-like Exo_endo_phos PF03372.18 KOO27792.1 - 5.1e-16 59.3 0.0 9.3e-16 58.5 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Gelsolin PF00626.17 KOO27793.1 - 1.7e-94 309.5 0.0 3.4e-19 68.3 0.0 6.3 6 0 0 6 6 6 6 Gelsolin repeat VHP PF02209.14 KOO27793.1 - 4.9e-08 32.5 0.5 8.8e-08 31.7 0.4 1.4 1 0 0 1 1 1 1 Villin headpiece domain Na_Ca_ex PF01699.19 KOO27794.1 - 2e-09 37.1 7.9 2.7e-09 36.7 5.5 1.2 1 0 0 1 1 1 1 Sodium/calcium exchanger protein zf-RanBP PF00641.13 KOO27795.1 - 1e-08 34.0 0.9 2e-08 33.1 0.6 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Herpes_capsid PF06112.6 KOO27795.1 - 1.4 8.9 3.7 2.5 8.1 2.5 1.4 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein MFS_1 PF07690.11 KOO27796.1 - 4.2e-33 114.5 34.5 7.7e-33 113.6 21.9 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 KOO27796.1 - 0.0023 16.5 18.2 0.0045 15.6 12.6 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter DUF1228 PF06779.9 KOO27796.1 - 0.0033 17.4 0.9 0.0033 17.4 0.7 2.8 3 1 0 3 3 3 1 Protein of unknown function (DUF1228) polyprenyl_synt PF00348.12 KOO27798.1 - 8e-57 192.0 0.1 1.3e-56 191.3 0.1 1.3 1 0 0 1 1 1 1 Polyprenyl synthetase ATP_bind_1 PF03029.12 KOO27798.1 - 3.2e-53 180.7 0.0 3.7e-41 141.2 0.0 2.4 1 1 1 2 2 2 2 Conserved hypothetical ATP binding protein AAA_17 PF13207.1 KOO27798.1 - 0.0003 21.5 0.0 0.001 19.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOO27798.1 - 0.00051 19.7 0.0 0.0017 18.0 0.0 1.9 1 0 0 1 1 1 1 Part of AAA domain ArgK PF03308.11 KOO27798.1 - 0.00069 18.4 0.0 0.0012 17.6 0.0 1.3 1 0 0 1 1 1 1 ArgK protein CbiA PF01656.18 KOO27798.1 - 0.004 16.5 0.0 0.018 14.4 0.0 2.1 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.9 KOO27798.1 - 0.0056 16.3 0.1 0.042 13.5 0.0 2.5 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B KTI12 PF08433.5 KOO27798.1 - 0.0057 15.9 0.0 0.044 12.9 0.0 2.1 2 0 0 2 2 2 1 Chromatin associated protein KTI12 AAA_10 PF12846.2 KOO27798.1 - 0.0071 15.8 0.0 0.013 14.9 0.0 1.4 1 0 0 1 1 1 1 AAA-like domain AAA_33 PF13671.1 KOO27798.1 - 0.011 15.6 0.0 0.096 12.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain WD40 PF00400.27 KOO27800.1 - 3.2e-59 194.8 34.9 9.4e-08 31.6 0.0 12.8 13 1 0 13 13 13 10 WD domain, G-beta repeat Inhibitor_I78 PF11720.3 KOO27800.1 - 0.095 12.4 0.0 0.39 10.4 0.0 2.0 2 0 0 2 2 2 0 Peptidase inhibitor I78 family SET PF00856.23 KOO27801.1 - 8.4e-05 22.9 0.0 0.0018 18.6 0.0 2.2 1 1 0 1 1 1 1 SET domain Arm PF00514.18 KOO27802.1 - 2.5e-29 100.0 65.5 3.5e-05 23.4 0.1 15.3 17 0 0 17 17 17 9 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO27802.1 - 3.5e-09 36.8 96.8 0.00021 21.5 3.3 12.2 5 4 6 11 11 11 5 HEAT repeats EF-hand_6 PF13405.1 KOO27802.1 - 8.7e-09 34.5 0.5 3.9e-05 23.1 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.27 KOO27802.1 - 2.9e-07 29.3 2.9 7.2e-06 24.9 0.0 2.8 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.1 KOO27802.1 - 5.5e-06 25.4 8.8 1.2e-05 24.4 0.4 2.9 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 KOO27802.1 - 8.9e-06 25.7 0.3 3.4e-05 23.8 0.2 1.8 1 1 0 1 1 1 1 EF-hand domain pair V-ATPase_H_N PF03224.9 KOO27802.1 - 0.00012 21.3 0.0 1.1 8.3 0.0 4.9 6 0 0 6 6 6 1 V-ATPase subunit H HEAT PF02985.17 KOO27802.1 - 0.0015 18.4 54.8 0.016 15.2 0.1 11.1 14 0 0 14 14 11 4 HEAT repeat Arm_2 PF04826.8 KOO27802.1 - 0.0023 17.0 0.1 7.5 5.5 0.0 4.4 4 1 1 5 5 5 1 Armadillo-like EF-hand_8 PF13833.1 KOO27802.1 - 0.003 17.1 0.0 0.014 14.9 0.0 2.2 1 0 0 1 1 1 1 EF-hand domain pair Proteasom_PSMB PF10508.4 KOO27802.1 - 0.042 12.1 0.7 4.6 5.3 0.0 3.8 4 0 0 4 4 4 0 Proteasome non-ATPase 26S subunit CLASP_N PF12348.3 KOO27802.1 - 0.33 10.2 6.9 0.093 12.0 0.2 3.0 4 0 0 4 4 4 0 CLASP N terminal MOR2-PAG1_N PF14222.1 KOO27802.1 - 0.35 9.5 0.0 20 3.7 0.0 2.4 2 0 0 2 2 2 0 Cell morphogenesis N-terminal PseudoU_synth_1 PF01416.15 KOO27805.1 - 2.2e-24 85.8 0.0 3.4e-14 53.1 0.0 2.4 2 0 0 2 2 2 2 tRNA pseudouridine synthase Rnk_N PF14760.1 KOO27805.1 - 0.0027 17.7 2.0 0.2 11.7 0.1 2.6 2 0 0 2 2 2 2 Rnk N-terminus UVR PF02151.14 KOO27805.1 - 0.057 12.9 0.3 0.16 11.5 0.2 1.7 1 0 0 1 1 1 0 UvrB/uvrC motif ACC_central PF08326.7 KOO27806.1 - 9.6e-19 66.9 0.1 1.3e-18 66.5 0.1 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Biotin_lipoyl PF00364.17 KOO27806.1 - 3.3e-06 26.6 0.4 1e-05 25.0 0.3 1.8 1 1 0 1 1 1 1 Biotin-requiring enzyme Pectate_lyase_3 PF12708.2 KOO27806.1 - 0.0039 17.3 0.2 0.011 15.8 0.1 1.8 1 0 0 1 1 1 1 Pectate lyase superfamily protein EF-hand_1 PF00036.27 KOO27807.1 - 1.7e-18 64.4 0.2 4.1e-05 22.5 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO27807.1 - 6.1e-16 56.8 0.6 0.0039 16.9 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO27807.1 - 1.2e-14 54.1 0.4 2.5e-06 27.5 0.1 3.3 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO27807.1 - 1e-12 46.7 1.1 0.0054 16.0 0.0 3.8 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 KOO27807.1 - 4.9e-05 22.8 1.5 0.13 11.9 0.2 3.8 3 1 0 3 3 3 2 EF-hand domain pair zf-RING_2 PF13639.1 KOO27807.1 - 0.066 13.0 0.1 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Ring finger domain ATP-synt_D PF01813.12 KOO27808.1 - 0.59 9.6 3.7 0.37 10.3 1.2 1.5 2 0 0 2 2 2 0 ATP synthase subunit D MPC PF03650.8 KOO27809.1 - 8.3e-40 135.4 0.2 9.6e-19 67.4 0.0 2.1 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0041) CAP_N PF01213.14 KOO27809.1 - 0.26 10.5 1.7 0.42 9.8 1.2 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Filamin PF00630.14 KOO27811.1 - 9.3e-26 90.3 0.0 1.1e-08 35.6 0.0 4.9 5 0 0 5 5 5 4 Filamin/ABP280 repeat Big_1 PF02369.11 KOO27811.1 - 0.00018 21.3 2.5 0.36 10.7 0.1 4.5 5 0 0 5 5 5 1 Bacterial Ig-like domain (group 1) IL12p40_C PF10420.4 KOO27811.1 - 0.1 12.7 0.0 0.27 11.3 0.0 1.7 1 0 0 1 1 1 0 Cytokine interleukin-12p40 C-terminus Filamin PF00630.14 KOO27812.1 - 1e-10 42.0 0.0 2.3e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 Filamin/ABP280 repeat Big_3_4 PF13754.1 KOO27812.1 - 0.0011 19.2 1.3 0.26 11.6 0.4 3.5 3 1 0 3 3 3 1 Bacterial Ig-like domain (group 3) AAA_34 PF13872.1 KOO27813.1 - 7.1e-103 343.5 0.0 1e-102 342.9 0.0 1.2 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.1 KOO27813.1 - 5.6e-67 226.0 0.4 9.8e-67 225.2 0.3 1.3 1 0 0 1 1 1 1 Helicase_C-like DUF4182 PF13790.1 KOO27813.1 - 3.9 7.3 19.6 0.15 11.8 9.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4182) cNMP_binding PF00027.24 KOO27815.1 - 1e-35 121.4 0.0 1.8e-20 72.5 0.0 2.2 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Cupin_2 PF07883.6 KOO27815.1 - 0.17 11.4 0.6 0.67 9.4 0.1 2.1 2 0 0 2 2 2 0 Cupin domain IncA PF04156.9 KOO27816.1 - 0.0036 16.9 11.4 0.049 13.2 2.2 2.3 2 0 0 2 2 2 2 IncA protein FlxA PF14282.1 KOO27816.1 - 0.025 14.5 2.0 0.052 13.4 1.4 1.5 1 0 0 1 1 1 0 FlxA-like protein COG2 PF06148.6 KOO27816.1 - 0.4 10.5 2.0 1.2 8.9 1.4 1.8 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4449 PF14613.1 KOO27816.1 - 2.7 7.8 6.3 0.5 10.2 1.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4449) Mnd1 PF03962.10 KOO27816.1 - 5.3 6.6 14.4 0.085 12.5 3.0 2.3 2 1 0 2 2 2 0 Mnd1 family Seryl_tRNA_N PF02403.17 KOO27816.1 - 6.7 6.7 9.2 0.5 10.4 2.3 2.1 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain NUC153 PF08159.7 KOO27817.1 - 2.2e-14 52.7 14.5 2.7e-11 42.8 0.6 3.8 3 0 0 3 3 3 3 NUC153 domain Dicer_dimer PF03368.9 KOO27817.1 - 0.095 12.4 0.0 0.38 10.5 0.0 2.1 1 0 0 1 1 1 0 Dicer dimerisation domain CTDII PF01556.13 KOO27818.1 - 1.5e-19 69.6 0.0 3.6e-19 68.4 0.0 1.6 2 0 0 2 2 2 1 DnaJ C terminal domain AAA_18 PF13238.1 KOO27819.1 - 1e-19 71.1 0.0 1.6e-19 70.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO27819.1 - 5.5e-11 43.3 0.7 1.9e-10 41.6 0.5 1.8 1 1 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.13 KOO27819.1 - 6.7e-06 25.7 0.0 1.6e-05 24.4 0.0 1.7 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_16 PF13191.1 KOO27819.1 - 0.00012 22.1 0.1 0.00015 21.8 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 KOO27819.1 - 0.0002 21.2 0.3 0.0015 18.4 0.2 2.6 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 KOO27819.1 - 0.00025 21.2 0.0 0.0015 18.7 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 KOO27819.1 - 0.00042 20.2 0.1 0.007 16.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KOO27819.1 - 0.00056 19.5 0.0 0.0011 18.6 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain NTPase_1 PF03266.10 KOO27819.1 - 0.0013 18.4 0.1 0.0047 16.6 0.0 1.9 2 1 0 2 2 2 1 NTPase AAA_22 PF13401.1 KOO27819.1 - 0.0017 18.5 0.5 0.0073 16.4 0.4 2.1 1 1 0 1 1 1 1 AAA domain ArgK PF03308.11 KOO27819.1 - 0.0019 17.0 0.1 0.0049 15.6 0.1 1.7 1 1 0 1 1 1 1 ArgK protein KTI12 PF08433.5 KOO27819.1 - 0.0038 16.4 0.0 0.018 14.2 0.0 1.9 2 0 0 2 2 2 1 Chromatin associated protein KTI12 AAA_10 PF12846.2 KOO27819.1 - 0.0054 16.1 0.0 0.0095 15.4 0.0 1.5 2 0 0 2 2 2 1 AAA-like domain Miro PF08477.8 KOO27819.1 - 0.01 16.3 0.0 0.019 15.4 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein DUF2075 PF09848.4 KOO27819.1 - 0.011 14.6 0.0 0.015 14.3 0.0 1.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TrwB_AAD_bind PF10412.4 KOO27819.1 - 0.014 14.0 0.1 0.029 12.9 0.0 1.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_32 PF13654.1 KOO27819.1 - 0.015 14.0 0.1 0.39 9.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 KOO27819.1 - 0.022 14.3 0.0 0.056 13.1 0.0 1.6 1 0 0 1 1 1 0 NACHT domain DUF815 PF05673.8 KOO27819.1 - 0.023 13.6 0.0 0.034 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ADK PF00406.17 KOO27819.1 - 0.032 14.1 0.0 0.3 10.9 0.0 2.1 2 0 0 2 2 2 0 Adenylate kinase AAA_29 PF13555.1 KOO27819.1 - 0.039 13.4 0.0 0.069 12.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain SNARE PF05739.14 KOO27819.1 - 0.046 13.4 0.8 0.21 11.3 0.1 2.2 2 0 0 2 2 2 0 SNARE domain RNA_helicase PF00910.17 KOO27819.1 - 0.055 13.6 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.9 KOO27819.1 - 0.057 13.1 0.0 0.12 12.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) KaiC PF06745.8 KOO27819.1 - 0.058 12.5 0.1 0.14 11.2 0.0 1.6 2 0 0 2 2 2 0 KaiC MobB PF03205.9 KOO27819.1 - 0.07 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B T2SE PF00437.15 KOO27819.1 - 0.087 11.7 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Mg_chelatase PF01078.16 KOO27819.1 - 0.1 11.7 0.0 0.24 10.5 0.0 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI MMR_HSR1 PF01926.18 KOO27819.1 - 0.11 12.5 0.0 0.32 10.9 0.0 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase cobW PF02492.14 KOO27819.1 - 0.11 11.9 0.1 0.28 10.6 0.0 1.6 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.12 KOO27819.1 - 0.12 11.8 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein DUF87 PF01935.12 KOO27819.1 - 0.15 11.8 0.8 1.2 8.9 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function DUF87 Na_H_Exchanger PF00999.16 KOO27821.1 - 1.1e-47 162.4 44.5 1.5e-47 161.9 30.9 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TrkA_N PF02254.13 KOO27821.1 - 9.1e-20 70.7 0.0 1.9e-19 69.7 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain EF-hand_5 PF13202.1 KOO27821.1 - 2.2e-13 48.8 0.5 1.7e-05 23.9 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO27821.1 - 2.2e-11 42.6 1.3 0.0003 20.4 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.27 KOO27821.1 - 4.2e-11 41.3 0.1 0.00016 20.6 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO27821.1 - 8.8e-09 35.3 0.2 3e-08 33.6 0.1 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO27821.1 - 1.8e-06 27.4 0.4 0.015 14.9 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair ACP_syn_III PF08545.5 KOO27821.1 - 0.032 13.8 0.0 0.7 9.5 0.0 2.7 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DNA_circ_N PF07157.7 KOO27821.1 - 0.13 12.4 0.0 3.8 7.6 0.0 2.6 2 0 0 2 2 2 0 DNA circularisation protein N-terminus COPIIcoated_ERV PF07970.7 KOO27822.1 - 7.1e-25 87.9 0.0 1.2e-24 87.2 0.0 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 KOO27822.1 - 2.4e-12 46.6 0.0 4.8e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Thioredoxin PF00085.15 KOO27822.1 - 2.4e-11 43.2 0.0 7.3e-11 41.6 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin ShK PF01549.19 KOO27822.1 - 8.3e-07 29.2 11.7 0.00052 20.3 2.3 2.4 2 0 0 2 2 2 2 ShK domain-like Thioredoxin_7 PF13899.1 KOO27822.1 - 0.14 12.2 0.1 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like ASC PF00858.19 KOO27822.1 - 0.31 9.6 2.7 0.6 8.7 1.9 1.4 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel SBBP PF06739.6 KOO27823.1 - 0.28 10.9 15.2 5.1 6.9 2.6 3.5 3 0 0 3 3 3 0 Beta-propeller repeat DUF2188 PF09954.4 KOO27823.1 - 2.6 8.0 4.7 73 3.3 0.7 3.6 3 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2188) Kelch_4 PF13418.1 KOO27824.1 - 3.4e-23 81.1 11.9 4.1e-08 32.8 0.0 7.4 8 0 0 8 8 8 5 Galactose oxidase, central domain Kelch_3 PF13415.1 KOO27824.1 - 2.5e-22 78.4 19.6 3e-05 24.0 0.3 9.8 10 0 0 10 10 10 5 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO27824.1 - 3.8e-14 52.2 0.3 0.0011 18.8 0.0 6.5 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 KOO27824.1 - 5e-10 39.1 0.0 3.4 8.0 0.0 6.9 6 1 1 7 7 7 3 Kelch motif TIG PF01833.19 KOO27824.1 - 2.7e-09 36.9 0.0 0.002 18.0 0.0 3.4 3 1 0 3 3 3 2 IPT/TIG domain Kelch_1 PF01344.20 KOO27824.1 - 9.7e-08 31.4 0.0 8.3 6.0 0.0 6.6 8 0 0 8 8 8 2 Kelch motif Kelch_2 PF07646.10 KOO27824.1 - 1.2e-07 31.2 0.0 2.1 8.2 0.0 5.9 5 0 0 5 5 5 2 Kelch motif PX PF00787.19 KOO27825.1 - 0.00019 21.1 0.0 0.00035 20.3 0.0 1.4 1 0 0 1 1 1 1 PX domain HC2 PF07382.6 KOO27826.1 - 2.5e-12 47.0 74.5 5.8e-12 45.8 51.7 1.5 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 Glyco_transf_8 PF01501.15 KOO27826.1 - 1.5e-06 27.7 0.0 5.6e-06 25.8 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferase family 8 ShK PF01549.19 KOO27826.1 - 0.00025 21.3 4.6 0.00025 21.3 3.2 3.0 3 0 0 3 3 3 1 ShK domain-like Asp-B-Hydro_N PF05279.6 KOO27826.1 - 4.8 6.9 21.1 12 5.6 14.6 1.6 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region TPR_12 PF13424.1 KOO27827.1 - 1.4e-25 89.0 7.3 1.1e-10 41.2 0.0 4.7 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO27827.1 - 7.7e-14 50.4 16.1 0.0012 18.5 0.0 6.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.1 KOO27827.1 - 8.8e-14 50.9 2.0 2.1e-06 27.2 0.0 4.8 2 1 3 5 5 5 4 TPR repeat TPR_10 PF13374.1 KOO27827.1 - 1.6e-13 50.0 0.6 0.0089 15.9 0.0 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO27827.1 - 2.5e-11 42.4 1.9 8.4e-06 25.2 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO27827.1 - 9.9e-11 40.7 14.6 1.3e-05 24.5 0.0 5.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO27827.1 - 3.4e-09 35.8 6.9 0.00074 19.1 0.0 5.3 6 0 0 6 6 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO27827.1 - 7.2e-09 35.5 3.3 5.6 7.8 0.0 6.4 6 1 0 6 6 5 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO27827.1 - 7e-07 29.7 2.1 0.0047 17.5 0.0 4.5 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOO27827.1 - 1.3e-05 25.3 1.8 2.7 8.6 0.0 5.1 5 1 0 5 5 3 1 Tetratricopeptide repeat SNAP PF14938.1 KOO27827.1 - 2.6e-05 23.5 4.0 0.36 9.9 0.0 3.7 1 1 3 4 4 4 3 Soluble NSF attachment protein, SNAP Foie-gras_1 PF11817.3 KOO27827.1 - 0.00082 18.9 2.1 0.63 9.4 0.1 3.1 3 0 0 3 3 3 2 Foie gras liver health family 1 RPN7 PF10602.4 KOO27827.1 - 0.026 13.9 5.2 5.9 6.2 0.0 4.4 3 2 1 4 4 4 0 26S proteasome subunit RPN7 CTP_transf_2 PF01467.21 KOO27827.1 - 0.097 12.7 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Cytidylyltransferase PPR PF01535.15 KOO27827.1 - 0.1 12.6 1.4 54 4.0 0.0 4.6 4 0 0 4 4 4 0 PPR repeat HEAT_PBS PF03130.11 KOO27827.1 - 0.19 12.3 2.3 16 6.2 0.0 4.3 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat TPR_19 PF14559.1 KOO27827.1 - 0.2 12.0 13.9 3 8.2 0.1 4.7 3 1 1 5 5 5 0 Tetratricopeptide repeat SufE PF02657.10 KOO27828.1 - 7.6e-31 106.3 0.0 1e-30 105.9 0.0 1.1 1 0 0 1 1 1 1 Fe-S metabolism associated domain BolA PF01722.13 KOO27828.1 - 4.3e-10 39.3 0.4 8.4e-10 38.4 0.3 1.5 1 0 0 1 1 1 1 BolA-like protein SBBP PF06739.6 KOO27829.1 - 0.0026 17.4 78.5 0.15 11.8 0.3 13.0 13 0 0 13 13 13 7 Beta-propeller repeat BRE PF06113.7 KOO27829.1 - 0.016 14.2 0.0 75 2.1 0.0 5.3 7 0 0 7 7 7 0 Brain and reproductive organ-expressed protein (BRE) FA_hydroxylase PF04116.8 KOO27831.1 - 8.7e-13 48.6 14.0 8.7e-13 48.6 9.7 1.9 2 1 1 3 3 3 1 Fatty acid hydroxylase superfamily Sulfotransfer_2 PF03567.9 KOO27832.1 - 2.2e-08 34.0 0.2 4.6e-06 26.5 0.0 2.3 2 0 0 2 2 2 2 Sulfotransferase family DUF1127 PF06568.6 KOO27832.1 - 0.065 12.6 0.1 0.065 12.6 0.1 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1127) N_methyl PF07963.7 KOO27833.1 - 0.066 12.9 1.8 0.14 11.9 1.3 1.6 1 0 0 1 1 1 0 Prokaryotic N-terminal methylation motif EF-hand_7 PF13499.1 KOO27834.1 - 5.7e-11 42.3 0.2 4.2e-10 39.6 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO27834.1 - 4.2e-10 38.6 0.2 1.7e-06 27.3 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO27834.1 - 7e-10 37.4 0.0 2e-05 23.5 0.0 3.0 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO27834.1 - 8.7e-06 25.2 1.0 4.4e-05 22.9 0.0 2.5 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO27834.1 - 0.0002 20.5 1.3 0.00057 19.1 0.0 2.5 3 0 0 3 3 3 1 EF hand EF-hand_9 PF14658.1 KOO27834.1 - 0.043 13.7 0.1 0.19 11.6 0.1 1.9 2 0 0 2 2 2 0 EF-hand domain PqqD PF05402.7 KOO27834.1 - 0.13 12.2 2.2 11 6.0 0.2 3.5 4 0 0 4 4 4 0 Coenzyme PQQ synthesis protein D (PqqD) CobN-Mg_chel PF02514.11 KOO27836.1 - 0 1093.8 0.0 0 1093.5 0.0 1.1 1 0 0 1 1 1 1 CobN/Magnesium Chelatase DUF3479 PF11965.3 KOO27836.1 - 7.9e-48 162.3 0.2 1.5e-47 161.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3479) PAP_fibrillin PF04755.7 KOO27839.1 - 1.9e-11 44.0 0.0 4.4e-11 42.8 0.0 1.6 1 1 0 1 1 1 1 PAP_fibrillin UPF0054 PF02130.12 KOO27840.1 - 2.7e-39 133.7 0.1 3.5e-39 133.3 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein family UPF0054 Galactosyl_T PF01762.16 KOO27841.1 - 0.13 11.7 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 Galactosyltransferase DUF809 PF05663.6 KOO27842.1 - 4.3 7.2 4.8 5.1 7.0 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF809) Chromo PF00385.19 KOO27843.1 - 2.1e-05 24.0 0.0 3.9e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Mito_carr PF00153.22 KOO27845.1 - 9.4e-22 76.5 8.7 6.2e-11 41.8 0.1 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein Dynamin_N PF00350.18 KOO27846.1 - 1.5e-12 47.6 0.0 6.8e-12 45.5 0.0 2.1 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 KOO27846.1 - 2.4e-05 24.2 0.0 0.00029 20.7 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.22 KOO27846.1 - 0.0013 19.0 0.0 0.0052 17.0 0.0 2.1 1 0 0 1 1 1 1 ABC transporter DUF258 PF03193.11 KOO27846.1 - 0.0023 17.1 0.0 0.0069 15.5 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF258 COX14 PF14880.1 KOO27846.1 - 0.037 13.6 0.3 0.25 11.0 0.0 2.4 2 0 0 2 2 2 0 Cytochrome oxidase c assembly Miro PF08477.8 KOO27846.1 - 0.042 14.3 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein DUF87 PF01935.12 KOO27846.1 - 0.12 12.1 0.6 0.43 10.3 0.4 1.9 1 0 0 1 1 1 0 Domain of unknown function DUF87 PP2C PF00481.16 KOO27847.1 - 3.1e-45 154.5 0.0 6.5e-45 153.5 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C Pkinase PF00069.20 KOO27847.1 - 1.9e-39 135.3 0.0 2.8e-39 134.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27847.1 - 3.2e-27 95.2 0.0 9.4e-25 87.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase PP2C_2 PF13672.1 KOO27847.1 - 1.5e-07 31.0 0.0 4e-07 29.6 0.0 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C Kinase-like PF14531.1 KOO27847.1 - 0.0014 17.6 0.0 0.0028 16.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like SAP PF02037.22 KOO27847.1 - 0.0036 16.7 3.3 0.0057 16.1 0.0 2.8 3 0 0 3 3 3 1 SAP domain Kdo PF06293.9 KOO27847.1 - 0.0087 15.1 0.0 0.018 14.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO27847.1 - 0.027 14.1 2.9 1.7 8.3 0.1 3.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family Armet PF10208.4 KOO27847.1 - 0.14 11.7 0.0 9.2 5.9 0.0 2.3 2 0 0 2 2 2 0 Degradation arginine-rich protein for mis-folding Sulfotransfer_3 PF13469.1 KOO27848.1 - 0.32 11.9 6.9 1 10.2 4.8 2.1 1 1 0 1 1 1 0 Sulfotransferase family zf-tcix PF14952.1 KOO27849.1 - 0.15 11.3 1.1 0.31 10.4 0.8 1.5 1 0 0 1 1 1 0 Putative treble-clef, zinc-finger, Zn-binding zf-RanBP PF00641.13 KOO27849.1 - 0.19 10.8 1.2 0.35 10.0 0.8 1.4 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others UPF0547 PF10571.4 KOO27849.1 - 0.78 9.4 3.1 0.69 9.6 1.0 1.6 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 NAD_binding_10 PF13460.1 KOO27850.1 - 2e-13 50.7 0.5 2.3e-13 50.5 0.4 1.1 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 KOO27850.1 - 1.5e-10 40.6 0.2 2e-10 40.3 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.14 KOO27850.1 - 1.5e-05 23.8 0.1 1.8e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 KOO27850.1 - 3.1e-05 23.5 0.0 3.8e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Saccharop_dh PF03435.13 KOO27850.1 - 0.0034 16.4 0.6 0.0041 16.1 0.4 1.1 1 0 0 1 1 1 1 Saccharopine dehydrogenase DapB_N PF01113.15 KOO27850.1 - 0.0081 16.0 0.4 0.013 15.4 0.3 1.4 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.19 KOO27850.1 - 0.015 15.5 0.1 0.023 15.0 0.1 1.4 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_4 PF07993.7 KOO27850.1 - 0.099 11.5 0.4 0.91 8.3 0.3 1.9 1 1 0 1 1 1 0 Male sterility protein PSK_trans_fac PF07704.6 KOO27851.1 - 0.00092 19.8 2.5 0.0012 19.4 1.7 1.2 1 0 0 1 1 1 1 Rv0623-like transcription factor Ribosomal_L37 PF08561.5 KOO27851.1 - 0.049 13.1 8.1 0.27 10.8 5.6 2.0 1 1 0 1 1 1 0 Mitochondrial ribosomal protein L37 DUF4557 PF15101.1 KOO27851.1 - 0.62 9.8 3.2 0.68 9.7 2.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Pkinase_Tyr PF07714.12 KOO27853.1 - 1.7e-20 73.1 0.0 4.5e-17 61.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.20 KOO27853.1 - 1.1e-17 64.1 0.0 2.9e-15 56.1 0.0 2.1 1 1 0 2 2 2 2 Protein kinase domain LRR_8 PF13855.1 KOO27853.1 - 4.6e-14 51.9 6.7 1.3e-06 28.0 0.0 4.2 1 1 4 5 5 5 4 Leucine rich repeat LRR_4 PF12799.2 KOO27853.1 - 3.1e-12 45.8 15.1 0.0035 16.9 0.7 6.1 2 1 6 8 8 8 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO27853.1 - 1.5e-05 24.3 7.3 1.6 9.0 0.1 6.9 6 1 1 7 7 7 1 Leucine Rich Repeat Kdo PF06293.9 KOO27853.1 - 0.0016 17.5 0.0 0.0025 16.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO27853.1 - 0.0076 16.0 0.1 0.29 10.8 0.0 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family LRR_6 PF13516.1 KOO27853.1 - 1.8 8.8 7.5 17 5.8 0.1 4.7 3 1 1 4 4 4 0 Leucine Rich repeat LRR_7 PF13504.1 KOO27853.1 - 2.6 8.6 16.7 29 5.4 0.1 6.8 7 0 0 7 7 7 0 Leucine rich repeat Phage_integrase PF00589.17 KOO27855.1 - 0.00011 21.9 0.0 0.00046 19.9 0.0 1.9 2 0 0 2 2 2 1 Phage integrase family HTH_37 PF13744.1 KOO27855.1 - 0.12 12.2 0.0 0.43 10.4 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain DUF1168 PF06658.7 KOO27857.1 - 2.7e-28 98.2 21.9 3.3e-28 97.9 15.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) D5_N PF08706.6 KOO27857.1 - 0.51 10.4 4.0 0.8 9.7 2.8 1.4 1 0 0 1 1 1 0 D5 N terminal like GAGA_bind PF06217.7 KOO27857.1 - 0.76 9.6 8.0 0.88 9.4 5.5 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Atg14 PF10186.4 KOO27857.1 - 1.6 7.6 8.1 2.1 7.2 5.6 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Sec62 PF03839.11 KOO27857.1 - 2 7.7 7.7 2.9 7.2 5.3 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Gti1_Pac2 PF09729.4 KOO27857.1 - 2.7 7.8 6.2 0.73 9.6 2.3 1.5 2 0 0 2 2 2 0 Gti1/Pac2 family DDHD PF02862.12 KOO27857.1 - 4.2 7.0 6.6 4.9 6.8 4.6 1.3 1 0 0 1 1 1 0 DDHD domain Peptidase_S49_N PF08496.5 KOO27857.1 - 4.8 6.9 11.7 3.8 7.2 6.6 1.9 2 0 0 2 2 2 0 Peptidase family S49 N-terminal PDT PF00800.13 KOO27857.1 - 7.7 6.0 7.0 4.7 6.7 3.7 1.5 2 0 0 2 2 2 0 Prephenate dehydratase BRF1 PF07741.8 KOO27857.1 - 7.7 6.8 19.2 5.6 7.2 11.5 2.0 2 0 0 2 2 2 0 Brf1-like TBP-binding domain AIG2 PF06094.7 KOO27859.1 - 7e-06 26.4 0.0 1.3e-05 25.6 0.0 1.5 1 0 0 1 1 1 1 AIG2-like family HEAT_2 PF13646.1 KOO27860.1 - 2.1e-05 24.7 15.4 0.046 14.0 0.0 5.8 3 2 2 5 5 5 3 HEAT repeats HEAT PF02985.17 KOO27860.1 - 0.0012 18.7 3.7 0.14 12.2 0.1 3.5 3 0 0 3 3 3 2 HEAT repeat HEAT_PBS PF03130.11 KOO27860.1 - 0.064 13.7 25.4 0.25 11.9 0.6 6.4 8 0 0 8 8 8 0 PBS lyase HEAT-like repeat Polyketide_cyc2 PF10604.4 KOO27861.1 - 1.8e-05 24.9 0.0 2.4e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Sulfotransfer_1 PF00685.22 KOO27862.1 - 2e-35 122.3 0.0 1.2e-34 119.8 0.0 1.9 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.1 KOO27862.1 - 5.9e-05 24.0 0.7 0.00061 20.7 0.5 2.3 1 1 0 1 1 1 1 Sulfotransferase family tRNA-synt_1 PF00133.17 KOO27863.1 - 7.9e-115 384.1 0.0 9.4e-115 383.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 KOO27863.1 - 5.6e-16 58.1 0.0 2.3e-08 33.1 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (M) Anticodon_1 PF08264.8 KOO27863.1 - 3.7e-09 36.5 0.0 7e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1_2 PF13603.1 KOO27863.1 - 9.5e-09 34.8 0.0 1.8e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.4 KOO27863.1 - 7.6e-08 32.3 0.3 7.6e-08 32.3 0.2 1.8 2 0 0 2 2 2 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1f PF01921.13 KOO27863.1 - 0.0027 16.4 0.0 0.0041 15.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (K) tRNA-synt_1e PF01406.14 KOO27863.1 - 0.031 13.4 0.0 0.047 12.8 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain tRNA-synt_1d PF00750.14 KOO27863.1 - 0.098 11.4 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (R) tRNA-synt_1 PF00133.17 KOO27864.1 - 1.6e-54 184.9 0.0 2e-54 184.6 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 KOO27864.1 - 4.5e-08 32.1 0.0 1.5e-07 30.4 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (M) tRNA-synt_1d PF00750.14 KOO27864.1 - 0.028 13.2 0.0 0.04 12.7 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (R) FUSC PF04632.7 KOO27864.1 - 0.19 10.1 4.2 0.26 9.6 2.9 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Exostosin PF03016.10 KOO27866.1 - 1.9e-33 115.8 0.2 3.6e-33 114.8 0.1 1.3 1 1 0 1 1 1 1 Exostosin family BNR_2 PF13088.1 KOO27867.1 - 1.3e-40 139.4 0.3 1.7e-40 139.0 0.2 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_3 PF13859.1 KOO27867.1 - 2.2e-12 46.6 0.0 3.4e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 KOO27867.1 - 7.5e-07 28.0 22.7 0.072 12.9 0.1 5.8 6 0 0 6 6 6 4 BNR/Asp-box repeat Mo-co_dimer PF03404.11 KOO27867.1 - 5.7 6.5 7.0 11 5.6 0.0 3.6 4 1 0 5 5 5 0 Mo-co oxidoreductase dimerisation domain DZR PF12773.2 KOO27868.1 - 0.0074 16.0 0.5 0.013 15.3 0.3 1.4 1 0 0 1 1 1 1 Double zinc ribbon Zn-ribbon_8 PF09723.5 KOO27868.1 - 0.013 15.4 0.1 0.029 14.3 0.1 1.6 1 0 0 1 1 1 0 Zinc ribbon domain SRP54 PF00448.17 KOO27868.1 - 0.023 14.1 0.2 0.043 13.2 0.2 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_16 PF13191.1 KOO27868.1 - 0.037 13.9 0.0 0.068 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain zf-TFIIB PF13453.1 KOO27868.1 - 0.061 12.5 0.4 0.13 11.4 0.3 1.6 1 0 0 1 1 1 0 Transcription factor zinc-finger Mito_fiss_reg PF05308.6 KOO27868.1 - 0.1 11.9 2.7 0.091 12.1 0.4 1.9 2 0 0 2 2 2 0 Mitochondrial fission regulator RNA_POL_M_15KD PF02150.11 KOO27868.1 - 0.1 12.2 0.1 0.19 11.4 0.1 1.3 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit zinc_ribbon_4 PF13717.1 KOO27868.1 - 0.12 12.0 0.9 0.54 9.9 0.6 2.2 1 1 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 KOO27868.1 - 0.13 11.9 0.9 0.52 9.9 0.6 2.1 1 1 0 1 1 1 0 zinc-ribbon domain ADK_lid PF05191.9 KOO27868.1 - 0.15 11.7 0.1 0.3 10.7 0.1 1.5 1 0 0 1 1 1 0 Adenylate kinase, active site lid HxlR PF01638.12 KOO27869.1 - 0.11 12.1 0.1 0.12 11.9 0.1 1.2 1 0 0 1 1 1 0 HxlR-like helix-turn-helix Ank_2 PF12796.2 KOO27870.1 - 4.3e-34 116.7 4.2 6.2e-12 45.7 0.1 2.8 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO27870.1 - 5e-27 92.3 8.1 2.5e-08 33.3 0.0 5.1 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.1 KOO27870.1 - 1.8e-20 72.4 7.3 4.8e-07 29.8 0.0 4.7 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO27870.1 - 3.5e-17 62.4 2.1 4.4e-09 36.6 0.1 3.4 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO27870.1 - 6.6e-16 56.8 2.1 0.00091 19.2 0.0 5.7 6 0 0 6 6 6 4 Ankyrin repeat TPR_11 PF13414.1 KOO27871.1 - 8.6e-39 131.0 65.4 1.2e-05 24.8 0.5 13.4 8 4 4 14 14 13 10 TPR repeat TPR_1 PF00515.23 KOO27871.1 - 3.8e-35 118.0 45.4 6.9e-05 22.2 0.2 15.5 16 0 0 16 16 16 9 Tetratricopeptide repeat TPR_2 PF07719.12 KOO27871.1 - 2.6e-34 114.3 69.0 0.003 17.3 0.2 18.0 20 0 0 20 20 18 12 Tetratricopeptide repeat TPR_17 PF13431.1 KOO27871.1 - 4.1e-31 104.5 31.6 0.0039 17.2 0.0 15.2 16 0 0 16 16 15 9 Tetratricopeptide repeat TPR_12 PF13424.1 KOO27871.1 - 5.4e-30 103.1 66.8 2.1e-06 27.5 0.9 13.6 6 3 9 15 15 15 10 Tetratricopeptide repeat TPR_16 PF13432.1 KOO27871.1 - 2.4e-29 101.3 102.1 5.9e-06 26.8 0.1 15.1 9 4 5 15 15 13 12 Tetratricopeptide repeat TPR_19 PF14559.1 KOO27871.1 - 2.3e-28 98.3 56.3 2.6e-06 27.6 0.5 12.8 7 2 8 15 15 15 10 Tetratricopeptide repeat TPR_14 PF13428.1 KOO27871.1 - 2.7e-22 77.2 76.3 0.00079 19.8 0.1 19.0 8 6 12 20 20 18 10 Tetratricopeptide repeat TPR_8 PF13181.1 KOO27871.1 - 3.7e-15 54.4 30.4 0.66 9.8 0.0 13.8 15 1 1 16 16 14 6 Tetratricopeptide repeat TPR_7 PF13176.1 KOO27871.1 - 4.8e-14 50.9 41.7 0.33 10.8 0.0 15.6 17 0 0 17 17 17 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOO27871.1 - 1.9e-09 37.3 47.8 0.67 10.5 0.1 16.3 18 0 0 18 18 16 4 Tetratricopeptide repeat TPR_10 PF13374.1 KOO27871.1 - 6.7e-05 22.6 41.7 0.08 12.9 0.1 13.0 13 1 1 14 14 13 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO27871.1 - 0.0006 19.6 22.5 0.003 17.3 0.1 7.4 8 1 1 9 9 7 2 Tetratricopeptide repeat Vps39_1 PF10366.4 KOO27871.1 - 0.02 14.8 0.2 5.3 7.1 0.0 2.8 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 ChAPs PF09295.5 KOO27871.1 - 0.036 12.8 0.8 0.55 8.9 0.1 2.4 1 1 1 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) NARP1 PF12569.3 KOO27871.1 - 1.1 7.9 40.8 0.59 8.8 0.2 5.2 4 1 0 5 5 5 0 NMDA receptor-regulated protein 1 Glycos_transf_1 PF00534.15 KOO27873.1 - 3.3e-22 78.6 0.0 1.3e-21 76.7 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 KOO27873.1 - 1.3e-12 48.0 0.1 5.7e-12 45.9 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.1 KOO27873.1 - 4.8e-05 23.2 0.1 7.3e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_4_4 PF13579.1 KOO27873.1 - 0.00073 19.7 0.0 0.00073 19.7 0.0 2.7 3 2 0 3 3 3 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.1 KOO27873.1 - 0.0054 16.4 0.1 0.011 15.4 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.1 KOO27873.1 - 0.037 14.3 0.0 0.084 13.1 0.0 1.7 1 0 0 1 1 1 0 Glycosyl transferases group 1 DENN PF02141.16 KOO27875.1 - 4.2e-26 91.8 0.6 5.4e-26 91.4 0.4 1.1 1 0 0 1 1 1 1 DENN (AEX-3) domain CPSase_L_D2 PF02786.12 KOO27876.1 - 4.1e-76 254.9 0.4 6.4e-76 254.3 0.3 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 KOO27876.1 - 1.3e-38 131.4 0.3 3.8e-38 129.9 0.1 1.9 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 KOO27876.1 - 7.4e-32 109.5 0.0 1.5e-31 108.5 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.17 KOO27876.1 - 1.9e-16 59.4 0.3 4.8e-16 58.1 0.0 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.1 KOO27876.1 - 1.2e-13 50.5 0.1 1.9e-08 33.4 0.0 2.1 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_4 PF13535.1 KOO27876.1 - 1.7e-13 50.7 0.1 4.6e-13 49.3 0.1 1.7 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 KOO27876.1 - 2.3e-07 30.4 0.3 1.1e-06 28.1 0.0 2.1 2 1 0 2 2 2 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 KOO27876.1 - 2.2e-06 27.1 0.1 3.7e-06 26.4 0.1 1.3 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.1 KOO27876.1 - 1.1e-05 24.9 0.3 0.01 15.4 0.0 2.6 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp_5 PF13549.1 KOO27876.1 - 0.00081 18.6 1.3 0.00089 18.5 0.1 1.6 2 0 0 2 2 2 1 ATP-grasp domain RimK PF08443.6 KOO27876.1 - 0.0024 17.3 0.0 0.016 14.6 0.0 2.0 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 KOO27876.1 - 0.014 15.2 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain DNA_circ_N PF07157.7 KOO27876.1 - 0.072 13.2 0.0 0.2 11.7 0.0 1.8 1 0 0 1 1 1 0 DNA circularisation protein N-terminus DUF218 PF02698.12 KOO27877.1 - 2.8e-07 30.1 0.4 9.8e-07 28.3 0.0 2.0 2 0 0 2 2 2 1 DUF218 domain LRR_4 PF12799.2 KOO27878.1 - 4.4e-11 42.1 14.3 2.1e-05 23.9 1.5 4.2 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO27878.1 - 4.2e-05 23.2 9.9 0.0061 16.2 0.7 3.4 2 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 KOO27878.1 - 0.00095 18.8 13.5 3.8 7.8 0.4 6.2 5 1 0 5 5 5 2 Leucine Rich Repeat LRR_7 PF13504.1 KOO27878.1 - 0.0028 17.5 10.9 32 5.3 0.1 6.2 6 0 0 6 6 6 0 Leucine rich repeat LRR_6 PF13516.1 KOO27878.1 - 0.63 10.2 11.5 67 4.0 0.0 5.7 5 1 1 6 6 6 0 Leucine Rich repeat RNase_H2_suC PF08615.6 KOO27880.1 - 7.2e-22 77.7 0.0 2.9e-21 75.7 0.0 1.9 1 1 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) AAA_28 PF13521.1 KOO27880.1 - 0.031 14.2 0.0 0.037 13.9 0.0 1.1 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.20 KOO27881.1 - 1.7e-65 220.7 0.0 2.1e-65 220.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27881.1 - 2.1e-33 115.4 0.0 3.1e-33 114.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO27881.1 - 1.9e-07 30.3 0.0 3.1e-07 29.6 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOO27881.1 - 1.2e-05 24.4 0.3 2e-05 23.7 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO27881.1 - 1.4e-05 24.9 3.2 3.2e-05 23.7 0.3 2.4 2 1 1 3 3 3 2 Phosphotransferase enzyme family RIO1 PF01163.17 KOO27881.1 - 0.00046 19.5 0.3 0.00071 18.9 0.2 1.2 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.15 KOO27881.1 - 0.011 15.2 0.6 0.048 13.2 0.4 1.8 1 1 0 1 1 1 0 Choline/ethanolamine kinase YukC PF10140.4 KOO27881.1 - 0.13 10.7 0.1 0.19 10.2 0.1 1.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Methyltransf_4 PF02390.12 KOO27882.1 - 2e-44 151.0 0.0 2e-43 147.7 0.0 1.9 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_31 PF13847.1 KOO27882.1 - 1e-07 31.6 0.0 1.6e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO27882.1 - 1.3e-07 32.2 0.0 5e-07 30.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO27882.1 - 1.4e-05 25.1 0.7 4.2e-05 23.5 0.5 1.8 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOO27882.1 - 0.00021 20.7 0.0 0.00094 18.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 KOO27882.1 - 0.00043 20.5 0.0 0.0011 19.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 KOO27882.1 - 0.00068 19.3 0.0 0.00096 18.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO27882.1 - 0.0015 18.9 0.0 0.0057 17.0 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO27882.1 - 0.0018 18.7 0.0 0.043 14.2 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO27882.1 - 0.0027 17.4 0.0 0.013 15.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain DUF3138 PF11336.3 KOO27882.1 - 0.018 13.2 3.3 0.026 12.7 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DOT1 PF08123.8 KOO27882.1 - 0.085 12.1 0.0 0.19 10.9 0.0 1.5 1 1 0 1 1 1 0 Histone methylation protein DOT1 ABC_membrane PF00664.18 KOO27883.1 - 6.5e-30 104.4 4.3 9.3e-30 103.9 3.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 KOO27883.1 - 2.5e-22 79.6 0.0 1.7e-12 47.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_33 PF13671.1 KOO27883.1 - 0.014 15.2 0.1 0.087 12.6 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.1 KOO27883.1 - 0.039 13.4 0.3 0.12 11.9 0.2 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.1 KOO27883.1 - 0.086 12.7 0.0 18 5.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 KOO27883.1 - 0.092 13.5 0.0 0.33 11.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.1 KOO27883.1 - 0.097 12.0 0.1 0.097 12.0 0.1 1.8 2 0 0 2 2 2 0 AAA domain DUF418 PF04235.7 KOO27883.1 - 0.35 10.5 4.4 1 9.0 3.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF418) Synaptobrevin PF00957.16 KOO27885.1 - 4.2e-22 77.5 0.8 4.8e-22 77.3 0.6 1.0 1 0 0 1 1 1 1 Synaptobrevin m04gp34like PF12216.3 KOO27885.1 - 0.0077 15.6 0.0 0.0096 15.2 0.0 1.0 1 0 0 1 1 1 1 Immune evasion protein Peptidase_C2 PF00648.16 KOO27886.1 - 5.1e-50 170.1 0.4 7.6e-50 169.5 0.2 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.17 KOO27886.1 - 4e-34 117.3 0.0 5.1e-13 48.9 0.0 3.7 3 0 0 3 3 3 3 Calpain large subunit, domain III zf-RING_2 PF13639.1 KOO27887.1 - 2.5e-10 39.9 6.6 3.3e-10 39.6 4.1 1.6 2 0 0 2 2 2 1 Ring finger domain WWE PF02825.15 KOO27887.1 - 5e-10 38.6 1.6 4.1e-05 22.9 0.0 2.8 2 1 1 3 3 3 2 WWE domain zf-rbx1 PF12678.2 KOO27887.1 - 5e-08 32.9 1.2 1.1e-07 31.8 0.8 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 KOO27887.1 - 4.4e-07 29.8 4.7 7e-07 29.1 3.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO27887.1 - 4.5e-07 29.4 4.3 7.3e-07 28.7 3.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO27887.1 - 1.8e-06 27.5 2.8 2.7e-06 26.9 2.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 KOO27887.1 - 3.6e-05 23.5 2.2 0.00014 21.5 1.5 2.0 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.1 KOO27887.1 - 0.00014 21.5 3.6 0.00022 20.8 2.5 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_4 PF14570.1 KOO27887.1 - 0.0028 17.2 2.8 0.0059 16.1 2.0 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-HC5HC2H PF13771.1 KOO27887.1 - 0.0048 17.0 1.3 0.019 15.0 0.2 2.1 1 1 1 2 2 2 1 PHD-like zinc-binding domain zf-RING_UBOX PF13445.1 KOO27887.1 - 0.0085 15.7 1.0 0.017 14.8 0.7 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-Nse PF11789.3 KOO27887.1 - 0.051 13.1 1.9 0.088 12.3 1.3 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING-like PF08746.6 KOO27887.1 - 0.057 13.4 4.0 0.12 12.3 2.8 1.6 1 0 0 1 1 1 0 RING-like domain PHD PF00628.24 KOO27887.1 - 0.092 12.4 2.3 0.19 11.4 1.6 1.6 1 0 0 1 1 1 0 PHD-finger zf-HC5HC2H_2 PF13832.1 KOO27887.1 - 0.12 12.4 1.5 0.18 11.8 0.2 1.8 1 1 1 2 2 2 0 PHD-zinc-finger like domain FANCL_C PF11793.3 KOO27887.1 - 0.19 11.7 3.4 0.6 10.1 2.4 1.8 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.1 KOO27887.1 - 0.38 10.6 2.2 0.93 9.4 1.5 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING COPIIcoated_ERV PF07970.7 KOO27888.1 - 1.5e-44 152.2 1.2 1.5e-41 142.4 0.8 2.1 1 1 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 KOO27888.1 - 5.9e-31 106.2 0.0 1.1e-30 105.4 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Barwin PF00967.12 KOO27888.1 - 0.098 12.3 0.2 0.19 11.3 0.2 1.4 1 0 0 1 1 1 0 Barwin family DUF1275 PF06912.6 KOO27890.1 - 2e-16 59.8 0.4 3e-16 59.2 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) Mito_carr PF00153.22 KOO27891.1 - 1.6e-57 191.1 1.6 5.4e-20 70.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF4235 PF14019.1 KOO27891.1 - 0.031 14.1 0.7 0.22 11.3 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4235) Cupin_8 PF13621.1 KOO27892.1 - 1.6e-26 93.3 0.0 2e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 KOO27892.1 - 0.00075 18.8 0.0 0.001 18.3 0.0 1.2 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_2 PF07883.6 KOO27892.1 - 0.0013 18.2 0.0 0.046 13.2 0.0 2.3 2 0 0 2 2 2 1 Cupin domain JmjC PF02373.17 KOO27892.1 - 0.0079 16.4 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_6 PF12852.2 KOO27892.1 - 0.011 15.3 0.0 0.017 14.7 0.0 1.4 1 0 0 1 1 1 0 Cupin ASF1_hist_chap PF04729.8 KOO27893.1 - 1.3e-64 216.4 0.1 1.4e-64 216.3 0.1 1.0 1 0 0 1 1 1 1 ASF1 like histone chaperone EF-hand_1 PF00036.27 KOO27894.1 - 1.2e-14 52.4 0.3 6.1e-06 25.1 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 KOO27894.1 - 3.2e-14 52.8 0.1 1e-13 51.1 0.0 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO27894.1 - 8.7e-13 46.9 0.2 2.8e-06 26.4 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO27894.1 - 1e-11 44.2 0.3 9.6e-09 34.7 0.0 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO27894.1 - 1.8e-10 39.7 0.1 6e-05 22.5 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_4 PF12763.2 KOO27894.1 - 0.00016 21.3 0.1 0.00092 18.9 0.0 2.0 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO27894.1 - 0.0013 18.7 0.1 0.0018 18.3 0.0 1.4 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region DUF2756 PF10956.3 KOO27894.1 - 0.083 13.1 0.7 0.083 13.1 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2756) DUF2681 PF10883.3 KOO27894.1 - 0.15 12.2 1.7 1.1 9.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Choline_kinase PF01633.15 KOO27895.1 - 9.6e-20 71.0 0.0 1.3e-19 70.5 0.0 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.18 KOO27895.1 - 1.5e-10 41.2 0.3 1.5e-10 41.2 0.2 2.5 2 1 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.15 KOO27895.1 - 0.15 11.1 0.0 1.6 7.7 0.0 2.2 1 1 0 1 1 1 0 Ecdysteroid kinase ASF1_hist_chap PF04729.8 KOO27896.1 - 1.3e-64 216.4 0.1 1.4e-64 216.3 0.1 1.0 1 0 0 1 1 1 1 ASF1 like histone chaperone Cu-oxidase_2 PF07731.9 KOO27899.1 - 0.017 14.6 0.2 0.026 14.0 0.2 1.3 1 0 0 1 1 1 0 Multicopper oxidase Homoserine_dh PF00742.14 KOO27900.1 - 1.8e-41 141.7 0.0 9.8e-41 139.3 0.0 2.3 2 0 0 2 2 2 1 Homoserine dehydrogenase AA_kinase PF00696.23 KOO27900.1 - 1.9e-41 142.2 0.2 8.1e-41 140.1 0.0 2.1 2 0 0 2 2 2 1 Amino acid kinase family NAD_binding_3 PF03447.11 KOO27900.1 - 1.2e-16 61.1 0.2 1.8e-15 57.3 0.0 2.9 3 0 0 3 3 3 1 Homoserine dehydrogenase, NAD binding domain ACT_7 PF13840.1 KOO27900.1 - 3.3e-10 39.3 0.3 1.3e-06 27.8 0.0 2.9 2 0 0 2 2 2 2 ACT domain ACT PF01842.20 KOO27900.1 - 5.9e-10 38.4 3.0 1.7e-05 24.1 0.0 2.9 3 0 0 3 3 3 2 ACT domain Semialdhyde_dh PF01118.19 KOO27900.1 - 0.0009 19.5 1.0 0.019 15.2 0.2 2.9 2 1 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_10 PF13460.1 KOO27900.1 - 0.39 10.7 5.9 1 9.3 0.6 3.2 3 0 0 3 3 3 0 NADH(P)-binding DnaJ PF00226.26 KOO27901.1 - 2.6e-14 52.6 3.0 2.6e-14 52.6 2.1 3.0 2 2 0 2 2 2 1 DnaJ domain AAA_11 PF13086.1 KOO27901.1 - 4.8 6.6 8.7 3.1 7.3 2.4 2.4 2 0 0 2 2 2 0 AAA domain Pox_MCEL PF03291.11 KOO27902.1 - 4.9e-64 216.2 0.0 6.9e-64 215.7 0.0 1.1 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_18 PF12847.2 KOO27902.1 - 1e-07 32.5 1.2 2.2e-07 31.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO27902.1 - 4.7e-06 26.8 0.1 1.1e-05 25.6 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO27902.1 - 7e-06 25.8 0.0 1.5e-05 24.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO27902.1 - 0.00051 19.6 0.0 0.00091 18.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO27902.1 - 0.011 16.2 0.0 0.034 14.6 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 KOO27902.1 - 0.015 15.7 0.0 0.048 14.1 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_9 PF08003.6 KOO27902.1 - 0.26 9.9 0.0 0.41 9.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_26 PF13659.1 KOO27902.1 - 3.2 7.8 6.0 0.31 11.0 0.6 2.0 2 0 0 2 2 2 0 Methyltransferase domain DSRB PF10781.4 KOO27903.1 - 0.0066 15.9 2.0 26 4.4 0.0 4.7 5 0 0 5 5 5 1 Dextransucrase DSRB Paired_CXXCH_1 PF09699.5 KOO27903.1 - 0.063 12.8 5.1 0.13 11.8 3.5 1.6 1 0 0 1 1 1 0 Doubled CXXCH motif (Paired_CXXCH_1) DUF1508 PF07411.7 KOO27903.1 - 3.1 7.3 7.8 35 3.9 0.1 4.7 5 0 0 5 5 5 0 Domain of unknown function (DUF1508) Gp37 PF09646.5 KOO27903.1 - 6 6.3 16.1 24 4.3 0.1 5.6 3 2 3 6 6 6 0 Gp37 protein DEAD PF00270.24 KOO27904.1 - 6.5e-32 110.3 0.0 7.3e-31 106.9 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO27904.1 - 6.1e-21 74.0 0.0 1.3e-20 72.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO27904.1 - 0.00043 20.1 0.0 0.0007 19.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit FIST PF08495.5 KOO27904.1 - 0.0048 16.0 0.3 0.034 13.2 0.1 2.5 2 1 0 2 2 2 1 FIST N domain AAA_22 PF13401.1 KOO27904.1 - 0.036 14.2 0.0 0.19 11.8 0.0 2.2 1 1 0 1 1 1 0 AAA domain DnaJ PF00226.26 KOO27905.1 - 4.6e-17 61.5 0.0 1.4e-16 59.9 0.0 1.9 1 0 0 1 1 1 1 DnaJ domain ADH_zinc_N PF00107.21 KOO27905.1 - 1.3e-06 27.9 0.0 3.2e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase SAM_1 PF00536.25 KOO27905.1 - 0.0011 19.0 0.5 0.01 15.9 0.4 2.5 2 1 0 2 2 2 1 SAM domain (Sterile alpha motif) ADH_N PF08240.7 KOO27905.1 - 0.0034 17.1 0.0 0.0062 16.2 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain SAM_2 PF07647.12 KOO27905.1 - 0.075 12.8 0.4 0.82 9.5 0.3 2.6 2 1 0 2 2 2 0 SAM domain (Sterile alpha motif) MIB_HERC2 PF06701.8 KOO27907.1 - 7.3e-19 67.5 8.0 1.6e-18 66.4 5.5 1.6 1 0 0 1 1 1 1 Mib_herc2 Erv26 PF04148.8 KOO27908.1 - 4.4e-40 137.3 21.0 1.7e-39 135.3 14.6 1.7 1 1 0 1 1 1 1 Transmembrane adaptor Erv26 DUF1270 PF06900.6 KOO27908.1 - 0.033 14.3 0.7 0.15 12.1 0.5 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1270) CTP_transf_1 PF01148.15 KOO27908.1 - 0.18 11.3 17.0 0.28 10.8 11.8 1.3 1 0 0 1 1 1 0 Cytidylyltransferase family BCDHK_Adom3 PF10436.4 KOO27910.1 - 1.9e-20 72.9 0.0 3.2e-20 72.2 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase EF-hand_1 PF00036.27 KOO27910.1 - 3.8e-11 41.4 0.1 0.00029 19.9 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO27910.1 - 5.7e-10 39.1 1.3 1.3e-09 38.0 0.9 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO27910.1 - 1.2e-09 37.2 0.2 0.00015 21.3 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO27910.1 - 9.6e-09 34.1 0.0 0.0035 16.6 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO27910.1 - 8e-08 31.7 0.1 0.00016 21.1 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair Rdx PF10262.4 KOO27910.1 - 4.7e-06 26.5 0.0 7.4e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Rdx family PP2C PF00481.16 KOO27911.1 - 1.1e-37 129.8 0.0 4.6e-29 101.5 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C ZZ PF00569.12 KOO27912.1 - 0.012 15.1 0.1 0.021 14.3 0.1 1.4 1 0 0 1 1 1 0 Zinc finger, ZZ type Med28 PF11594.3 KOO27912.1 - 0.042 14.0 0.7 4.2 7.6 0.0 2.1 1 1 1 2 2 2 0 Mediator complex subunit 28 TPD52 PF04201.10 KOO27912.1 - 0.062 13.0 0.8 0.095 12.4 0.5 1.3 1 0 0 1 1 1 0 Tumour protein D52 family NYD-SP28 PF14772.1 KOO27912.1 - 0.16 12.0 1.2 0.3 11.2 0.8 1.5 1 0 0 1 1 1 0 Sperm tail TMF_DNA_bd PF12329.3 KOO27912.1 - 2 8.2 6.3 3.6 7.4 1.1 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding PKD_channel PF08016.7 KOO27914.1 - 5.3e-11 41.5 12.3 1.1e-05 24.0 7.6 2.2 1 1 1 2 2 2 2 Polycystin cation channel Ion_trans PF00520.26 KOO27914.1 - 0.13 11.4 18.1 0.16 11.2 11.6 1.9 2 1 0 2 2 2 0 Ion transport protein Pkinase PF00069.20 KOO27915.1 - 2.1e-60 204.0 0.0 2.5e-60 203.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27915.1 - 1.3e-41 142.3 0.0 1.7e-41 141.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO27915.1 - 0.00027 19.9 0.0 0.0029 16.6 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 KOO27915.1 - 0.017 14.8 0.0 0.82 9.3 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family VCBS PF13517.1 KOO27916.1 - 7.8e-144 468.1 167.7 6.3e-15 55.2 3.4 13.4 1 1 13 14 14 14 14 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO27916.1 - 1.4e-73 241.0 126.0 3.6e-06 26.5 2.0 13.4 13 0 0 13 13 13 13 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO27916.1 - 3.7e-31 107.9 49.5 0.078 12.4 0.1 13.0 2 2 11 13 13 13 13 Insecticide toxin TcdB middle/N-terminal region DUF4384 PF14326.1 KOO27916.1 - 3e-11 42.9 0.1 28 4.6 0.0 11.3 1 1 12 13 13 13 0 Domain of unknown function (DUF4384) Arrestin_N PF00339.24 KOO27916.1 - 1.5e-07 31.3 0.0 48 3.7 0.0 9.8 13 0 0 13 13 13 0 Arrestin (or S-antigen), N-terminal domain YuzL PF14115.1 KOO27916.1 - 0.0034 17.6 27.1 90 3.4 0.0 11.9 13 0 0 13 13 13 0 YuzL-like protein EF-hand_5 PF13202.1 KOO27916.1 - 0.025 13.9 86.2 9.5 5.7 0.3 13.6 13 0 0 13 13 13 0 EF hand Glyco_transf_56 PF07429.6 KOO27916.1 - 0.042 12.7 0.5 1.5e+02 1.1 0.0 5.8 8 0 0 8 8 8 0 4-alpha-L-fucosyltransferase glycosyl transferase group 56 LCAT PF02450.10 KOO27916.1 - 0.05 12.5 0.4 4e+02 -0.3 0.0 6.5 11 0 0 11 11 11 0 Lecithin:cholesterol acyltransferase BBS2_Mid PF14783.1 KOO27916.1 - 0.99 9.2 17.8 1.6e+02 2.1 0.0 9.7 13 0 0 13 13 13 0 Ciliary BBSome complex subunit 2, middle region EF-hand_1 PF00036.27 KOO27916.1 - 4.3 6.8 63.6 34 4.0 0.1 13.1 13 0 0 13 13 13 0 EF hand FIST PF08495.5 KOO27917.1 - 2.1e-06 27.0 0.8 5.4e-06 25.6 0.6 1.8 1 0 0 1 1 1 1 FIST N domain FIST_C PF10442.4 KOO27917.1 - 0.0026 17.7 0.1 1.8 8.5 0.0 2.6 2 0 0 2 2 2 2 FIST C domain Ank_2 PF12796.2 KOO27920.1 - 1.3e-46 156.8 11.9 5.5e-18 65.0 0.8 2.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO27920.1 - 2.3e-29 99.7 19.1 3.3e-06 26.6 0.0 5.6 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.1 KOO27920.1 - 1.6e-26 92.2 3.0 2.1e-10 40.8 0.2 3.9 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO27920.1 - 1.5e-25 86.6 4.1 4.2e-05 23.3 0.0 5.4 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.1 KOO27920.1 - 8.7e-24 83.0 13.9 7.6e-09 35.5 0.5 5.3 1 1 4 5 5 5 5 Ankyrin repeats (many copies) SNF2_N PF00176.18 KOO27921.1 - 2.2e-47 161.2 0.0 3.9e-37 127.6 0.0 2.4 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.26 KOO27921.1 - 5.8e-14 51.7 0.1 1.8e-13 50.1 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Agenet PF05641.7 KOO27921.1 - 1.2e-11 44.5 0.2 6.3e-05 23.0 0.0 3.4 3 0 0 3 3 3 2 Agenet domain HDA2-3 PF11496.3 KOO27921.1 - 7.1e-11 41.4 0.0 1.3e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.24 KOO27921.1 - 2.1e-07 30.6 0.0 5.5e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase MHC_II_alpha PF00993.15 KOO27921.1 - 0.14 11.7 0.1 0.32 10.5 0.1 1.6 1 0 0 1 1 1 0 Class II histocompatibility antigen, alpha domain SET PF00856.23 KOO27921.1 - 0.15 12.3 0.6 0.78 10.0 0.1 2.4 3 0 0 3 3 3 0 SET domain THOC7 PF05615.8 KOO27923.1 - 0.16 12.2 3.2 0.15 12.3 1.3 1.6 2 0 0 2 2 2 0 Tho complex subunit 7 zf-C3HC4_3 PF13920.1 KOO27923.1 - 1.2 8.8 10.9 2.9 7.6 7.6 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO27923.1 - 4.8 7.0 11.4 20 5.0 8.0 2.0 1 1 0 1 1 1 0 Ring finger domain Pkinase PF00069.20 KOO27924.1 - 2.9e-56 190.4 0.0 3.6e-56 190.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27924.1 - 4.3e-37 127.5 0.0 5.9e-37 127.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO27924.1 - 4.9e-06 25.7 0.0 0.00014 20.9 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Xylanase PF13201.1 KOO27924.1 - 0.01 14.6 0.0 0.016 14.0 0.0 1.2 1 0 0 1 1 1 0 Putative glycoside hydrolase xylanase APH PF01636.18 KOO27924.1 - 0.2 11.3 3.0 0.55 9.9 0.2 2.5 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kinesin PF00225.18 KOO27926.1 - 2.2e-75 253.4 0.0 3.5e-75 252.7 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Gp58 PF07902.6 KOO27926.1 - 0.28 9.3 2.0 0.47 8.6 1.4 1.2 1 0 0 1 1 1 0 gp58-like protein SR-25 PF10500.4 KOO27926.1 - 1.3 8.4 23.7 0.079 12.4 0.5 3.0 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein AAA_22 PF13401.1 KOO27926.1 - 3.2 7.9 5.1 1.9 8.6 0.4 2.3 2 0 0 2 2 2 0 AAA domain EF-hand_7 PF13499.1 KOO27927.1 - 4.6e-41 138.7 13.0 8.7e-15 54.6 0.2 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO27927.1 - 3.2e-33 110.5 28.3 9.5e-07 27.6 0.2 6.4 6 0 0 6 6 6 6 EF hand EF-hand_5 PF13202.1 KOO27927.1 - 1.2e-30 103.4 30.4 3.1e-07 29.4 0.6 6.4 6 0 0 6 6 6 5 EF hand EF-hand_6 PF13405.1 KOO27927.1 - 7.1e-30 100.1 22.5 1.9e-06 27.2 0.2 6.4 6 0 0 6 6 6 6 EF-hand domain EF-hand_8 PF13833.1 KOO27927.1 - 1.7e-22 78.7 24.7 9.4e-08 31.5 0.3 6.3 4 2 2 6 6 6 5 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO27927.1 - 5.2e-06 26.4 1.1 0.16 12.0 0.1 4.0 3 2 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region DUF1789 PF08748.6 KOO27927.1 - 0.0025 17.9 1.3 0.094 12.8 0.3 3.1 2 1 0 2 2 2 1 Domain of unknown function (DUF1789) Barwin PF00967.12 KOO27927.1 - 0.011 15.3 5.7 34 4.1 0.0 5.0 3 2 2 5 5 5 0 Barwin family Excalibur PF05901.6 KOO27927.1 - 0.029 14.7 5.6 9.3 6.6 0.1 4.9 5 0 0 5 5 5 0 Excalibur calcium-binding domain EF-hand_4 PF12763.2 KOO27927.1 - 0.046 13.4 8.2 7.7 6.3 0.0 4.5 3 2 2 5 5 5 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO27927.1 - 1 9.0 11.1 21 4.8 0.2 5.0 6 0 0 6 6 6 0 EF hand CRAL_TRIO PF00650.15 KOO27928.1 - 9.7e-30 103.1 0.0 5.3e-15 55.2 0.0 2.2 2 0 0 2 2 2 2 CRAL/TRIO domain CRAL_TRIO_2 PF13716.1 KOO27928.1 - 0.0003 20.6 0.0 0.0033 17.3 0.0 2.2 2 1 0 2 2 2 1 Divergent CRAL/TRIO domain Baculo_p26 PF04766.7 KOO27928.1 - 0.081 12.1 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus p26 protein His_Phos_2 PF00328.17 KOO27930.1 - 6.9e-22 78.2 0.0 3e-21 76.1 0.0 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) TIR_2 PF13676.1 KOO27931.1 - 8e-07 29.1 0.0 2.5e-06 27.5 0.0 1.8 2 0 0 2 2 2 1 TIR domain TIR PF01582.15 KOO27931.1 - 0.058 12.8 0.1 0.12 11.8 0.1 1.5 1 0 0 1 1 1 0 TIR domain NAD_binding_1 PF00175.16 KOO27932.1 - 1.9e-16 60.5 0.0 2.7e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain SIS_2 PF13580.1 KOO27932.1 - 0.0038 16.9 0.0 0.0057 16.3 0.0 1.2 1 0 0 1 1 1 1 SIS domain Flavodoxin_1 PF00258.20 KOO27933.1 - 4.2e-32 111.1 0.0 6.1e-32 110.5 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.15 KOO27933.1 - 2.8e-10 40.0 0.0 4.2e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_NdrI PF07972.6 KOO27933.1 - 0.00029 20.7 0.0 0.00052 19.9 0.0 1.3 1 0 0 1 1 1 1 NrdI Flavodoxin like Flavodoxin_5 PF12724.2 KOO27933.1 - 0.00067 19.6 0.0 0.00097 19.1 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin domain Flavodoxin_3 PF12641.2 KOO27933.1 - 0.0008 18.8 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin domain polyprenyl_synt PF00348.12 KOO27934.1 - 7.3e-68 228.2 0.1 9.1e-68 227.9 0.1 1.0 1 0 0 1 1 1 1 Polyprenyl synthetase HSP70 PF00012.15 KOO27935.1 - 1e-272 905.4 10.4 1.2e-272 905.2 7.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KOO27935.1 - 1.5e-16 59.9 0.6 6e-15 54.6 0.1 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.1 KOO27935.1 - 0.00023 20.9 3.1 0.018 14.8 2.1 3.8 1 1 0 1 1 1 1 Cell division protein FtsA Hydantoinase_A PF01968.13 KOO27935.1 - 0.00024 20.3 8.6 0.0018 17.4 0.1 3.8 3 1 0 4 4 4 1 Hydantoinase/oxoprolinase AAA_23 PF13476.1 KOO27935.1 - 1.3 9.3 11.3 0.16 12.3 4.8 1.6 2 0 0 2 2 2 0 AAA domain SpoIIAA-like PF11964.3 KOO27935.1 - 1.7 8.9 4.2 1.2 9.4 0.2 2.8 3 1 0 3 3 3 0 SpoIIAA-like DUF883 PF05957.8 KOO27935.1 - 5.2 7.5 10.6 0.92 9.9 1.9 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) PhyH PF05721.8 KOO27937.1 - 7.4e-05 22.8 0.0 0.17 11.8 0.0 2.5 2 1 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) STAG PF08514.6 KOO27939.1 - 9.2e-11 41.4 0.1 1.7e-10 40.6 0.1 1.3 1 0 0 1 1 1 1 STAG domain HEAT_2 PF13646.1 KOO27939.1 - 0.02 15.1 3.8 1.6 9.0 0.3 3.6 1 1 3 4 4 4 0 HEAT repeats HEAT PF02985.17 KOO27939.1 - 0.14 12.2 8.9 10 6.4 0.0 5.0 6 0 0 6 6 6 0 HEAT repeat DUF3523 PF12037.3 KOO27939.1 - 0.23 10.4 3.1 0.37 9.7 2.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) HECT PF00632.20 KOO27940.1 - 2e-47 161.8 0.0 3.4e-47 161.1 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Ank_2 PF12796.2 KOO27940.1 - 1.6e-11 44.3 0.0 5.7e-11 42.6 0.0 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO27940.1 - 3.5e-09 36.0 6.6 0.00034 20.2 0.2 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.1 KOO27940.1 - 2.3e-08 34.3 0.1 0.00085 19.7 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO27940.1 - 3.2e-07 29.9 0.1 0.056 13.6 0.0 3.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 KOO27940.1 - 3.4e-07 30.3 0.4 0.0076 16.4 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) ZZ PF00569.12 KOO27940.1 - 0.0039 16.7 0.1 0.0077 15.7 0.0 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type DUF4537 PF15057.1 KOO27940.1 - 0.31 10.8 0.0 0.61 9.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) Hist_deacetyl PF00850.14 KOO27942.1 - 7e-68 229.2 0.1 9.7e-68 228.7 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Stc1 PF12898.2 KOO27942.1 - 0.00069 19.6 0.8 0.0012 18.8 0.6 1.4 1 0 0 1 1 1 1 Stc1 domain zf-RING_2 PF13639.1 KOO27943.1 - 7.9e-06 25.6 6.6 0.029 14.2 0.8 2.7 2 0 0 2 2 2 2 Ring finger domain zf-C3HC4 PF00097.20 KOO27943.1 - 0.015 14.9 6.7 0.066 12.8 0.5 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO27943.1 - 0.02 14.9 5.8 2.1 8.4 0.3 2.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) RPEL PF02755.10 KOO27943.1 - 0.071 12.4 0.0 0.15 11.4 0.0 1.6 1 0 0 1 1 1 0 RPEL repeat DUF2205 PF10224.4 KOO27943.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Predicted coiled-coil protein (DUF2205) zf-C3HC4_3 PF13920.1 KOO27943.1 - 0.14 11.8 6.8 2 8.1 0.3 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 KOO27943.1 - 0.34 10.8 4.6 1.8 8.4 0.5 3.0 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 KOO27943.1 - 0.46 10.2 6.2 0.47 10.2 0.4 2.6 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_UBOX PF13445.1 KOO27943.1 - 1 9.1 3.8 0.55 9.9 0.2 2.4 2 1 0 2 2 2 0 RING-type zinc-finger SMC_N PF02463.14 KOO27944.1 - 1.5e-61 207.4 1.3 1.9e-61 207.0 0.9 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 KOO27944.1 - 2.6e-20 72.5 0.5 2.6e-20 72.5 0.3 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 KOO27944.1 - 1.1e-09 38.7 0.0 0.0004 20.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.1 KOO27944.1 - 2e-09 38.0 12.7 2e-09 38.0 8.8 6.1 2 2 0 2 2 2 1 AAA domain AAA_29 PF13555.1 KOO27944.1 - 0.00017 21.0 0.0 0.00037 19.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 KOO27944.1 - 0.00027 20.0 0.7 0.76 8.7 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain SNF2_N PF00176.18 KOO27945.1 - 6.4e-56 189.3 0.0 8.4e-56 188.9 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.19 KOO27945.1 - 1e-17 63.4 0.0 1.4e-07 31.0 0.0 2.4 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.26 KOO27945.1 - 8.8e-16 57.5 0.0 1.7e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 KOO27945.1 - 9.5e-09 34.4 0.0 1.6e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.24 KOO27945.1 - 0.00037 20.0 0.0 0.21 11.0 0.0 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.10 KOO27945.1 - 0.003 17.4 0.0 2.3 8.0 0.0 2.6 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit DEAD_2 PF06733.10 KOO27945.1 - 0.27 10.6 0.0 0.57 9.5 0.0 1.4 1 0 0 1 1 1 0 DEAD_2 Cyclin PF08613.6 KOO27946.1 - 2.2e-22 80.0 0.0 3.9e-22 79.2 0.0 1.5 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 KOO27946.1 - 0.0011 18.5 0.1 0.002 17.6 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain FKBP_C PF00254.23 KOO27947.1 - 1.1e-23 82.9 0.0 2e-23 82.2 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.13 KOO27947.1 - 0.042 13.8 0.1 0.072 13.1 0.1 1.3 1 0 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Jun PF03957.8 KOO27947.1 - 0.3 10.7 2.3 0.49 10.0 1.5 1.4 1 1 0 1 1 1 0 Jun-like transcription factor Ion_trans PF00520.26 KOO27948.1 - 1.2e-08 34.4 8.7 3.5e-08 32.9 6.0 1.8 1 1 0 1 1 1 1 Ion transport protein Nodulin-like PF06813.8 KOO27950.1 - 9.1e-10 38.2 6.7 2.1e-09 37.0 4.7 1.6 1 0 0 1 1 1 1 Nodulin-like MFS_1 PF07690.11 KOO27950.1 - 3.4e-07 29.3 49.5 3.9e-06 25.8 34.3 2.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Pkinase PF00069.20 KOO27951.1 - 3.4e-50 170.6 0.0 3.8e-50 170.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27951.1 - 1.5e-24 86.5 0.0 1.8e-24 86.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO27951.1 - 0.0025 16.8 0.1 0.0037 16.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 KOO27951.1 - 0.02 13.8 0.3 1.3 7.8 0.1 3.1 2 1 1 3 3 3 0 Kinase-like YrbL-PhoP_reg PF10707.4 KOO27951.1 - 0.041 13.2 0.0 1.4 8.1 0.0 2.2 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL APH PF01636.18 KOO27951.1 - 0.15 11.7 2.3 0.86 9.2 1.7 2.1 1 1 0 1 1 1 0 Phosphotransferase enzyme family ADH_N PF08240.7 KOO27952.1 - 1.8e-21 75.9 1.3 4.6e-21 74.6 0.9 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 KOO27952.1 - 1.3e-19 70.0 0.1 2.4e-19 69.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 KOO27952.1 - 0.0051 15.9 0.0 0.0091 15.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ThiF PF00899.16 KOO27952.1 - 0.072 12.9 0.5 1.3 8.8 0.2 2.7 3 0 0 3 3 3 0 ThiF family VPEP PF07589.6 KOO27952.1 - 0.16 11.9 2.6 0.66 9.9 0.1 2.7 2 0 0 2 2 2 0 PEP-CTERM motif AdoHcyase_NAD PF00670.16 KOO27952.1 - 0.75 9.6 3.5 0.28 11.0 0.5 1.7 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain LRR_6 PF13516.1 KOO27955.1 - 3.2e-76 242.8 179.5 0.026 14.5 0.4 38.9 39 0 0 39 39 39 31 Leucine Rich repeat LRR_4 PF12799.2 KOO27955.1 - 2.3e-53 177.0 89.9 0.0036 16.8 0.5 24.2 16 5 6 26 26 26 23 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO27955.1 - 9.5e-19 64.5 64.2 2.5 8.4 0.1 30.0 34 3 0 34 34 34 1 Leucine Rich Repeat LRR_7 PF13504.1 KOO27955.1 - 3.3e-10 38.4 146.0 27 5.5 0.1 36.2 39 0 0 39 39 39 0 Leucine rich repeat DUF3140 PF11338.3 KOO27955.1 - 5.6e-09 35.9 0.3 15 5.8 0.0 9.5 10 0 0 10 10 10 1 Protein of unknown function (DUF3140) NACHT PF05729.7 KOO27955.1 - 0.0018 17.9 0.1 0.0036 16.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain DUF4030 PF13222.1 KOO27955.1 - 0.0051 16.5 5.7 1.1e+02 2.4 0.0 8.2 11 0 0 11 11 11 0 Protein of unknown function (DUF4030) Hce2 PF14856.1 KOO27955.1 - 0.034 14.0 7.6 2.4e+02 1.6 0.0 8.1 6 4 5 11 11 11 0 Pathogen effector; putative necrosis-inducing factor LRR_8 PF13855.1 KOO27955.1 - 0.15 11.8 124.9 2.5 7.9 2.1 20.7 9 4 17 26 26 26 0 Leucine rich repeat COPI_assoc PF08507.5 KOO27956.1 - 2.5e-15 56.3 1.9 3.1e-15 56.0 1.3 1.1 1 0 0 1 1 1 1 COPI associated protein Cg6151-P PF10233.4 KOO27956.1 - 0.00019 21.3 5.0 0.00032 20.6 3.5 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P IncA PF04156.9 KOO27956.1 - 0.12 11.9 8.6 1.4 8.4 4.2 2.2 2 0 0 2 2 2 0 IncA protein Pkinase PF00069.20 KOO27957.1 - 1.4e-27 96.5 0.0 1.7e-27 96.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27957.1 - 4.5e-09 35.7 0.0 7.5e-09 35.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO27957.1 - 9.9e-05 22.1 1.9 0.00031 20.5 0.1 2.4 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 KOO27957.1 - 0.024 13.6 0.0 0.051 12.6 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 KOO27957.1 - 0.081 12.2 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.1 KOO27957.1 - 0.12 11.2 0.0 0.27 10.1 0.0 1.5 1 1 0 1 1 1 0 Kinase-like SHIPPO-rpt PF07004.7 KOO27958.1 - 0.00015 22.5 39.7 0.0091 16.8 0.1 7.7 7 1 0 7 7 7 4 Sperm-tail PG-rich repeat VWA_2 PF13519.1 KOO27959.1 - 2.9e-18 66.5 0.2 5.8e-18 65.5 0.1 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 KOO27959.1 - 6.4e-17 61.8 0.0 9.6e-17 61.2 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.1 KOO27959.1 - 9.9e-16 57.7 0.5 2.9e-15 56.2 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain Beta-lactamase PF00144.19 KOO27961.1 - 1e-21 77.3 0.0 5.9e-21 74.8 0.0 1.9 1 1 0 1 1 1 1 Beta-lactamase EF-hand_1 PF00036.27 KOO27963.1 - 2.2e-31 104.7 5.8 7e-07 28.1 0.2 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO27963.1 - 5.7e-27 91.1 6.3 9.7e-08 31.2 0.3 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO27963.1 - 1e-24 86.4 6.0 1.3e-11 44.4 0.1 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO27963.1 - 1.1e-20 71.9 4.9 8e-05 21.7 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO27963.1 - 5.5e-20 70.7 10.7 8.1e-10 38.1 0.2 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.1 KOO27963.1 - 1.1e-06 28.4 0.3 0.00024 20.9 0.0 2.8 2 1 0 2 2 2 1 EF-hand domain EF-hand_10 PF14788.1 KOO27963.1 - 3.2e-06 26.7 0.4 0.014 15.0 0.0 2.9 2 1 1 3 3 3 2 EF hand EF-hand_4 PF12763.2 KOO27963.1 - 0.016 14.9 5.9 1 9.1 0.2 3.7 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO27963.1 - 0.037 14.0 0.0 2.4 8.2 0.0 2.5 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.8 KOO27963.1 - 0.11 12.2 3.5 1.3 8.7 0.3 3.7 2 1 1 3 3 3 0 Tellurite resistance protein TerB Mlo PF03094.10 KOO27963.1 - 0.25 9.3 12.4 0.24 9.4 0.0 3.2 4 0 0 4 4 4 0 Mlo family Orai-1 PF07856.7 KOO27964.1 - 3.4e-09 36.5 7.5 1.9e-08 34.0 5.2 1.8 1 1 0 1 1 1 1 Mediator of CRAC channel activity DUF3955 PF13127.1 KOO27964.1 - 0.038 13.5 2.5 0.087 12.3 1.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3955) NfeD PF01957.13 KOO27964.1 - 0.081 13.0 0.4 0.081 13.0 0.3 2.0 2 0 0 2 2 2 0 NfeD-like C-terminal, partner-binding SPC25 PF06703.6 KOO27964.1 - 1.2 8.6 8.2 16 5.0 0.0 2.2 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Choline_transpo PF04515.7 KOO27965.1 - 1.3e-62 211.4 37.6 1.7e-62 211.1 22.3 2.8 3 0 0 3 3 3 2 Plasma-membrane choline transporter Thioredoxin PF00085.15 KOO27966.1 - 4.9e-20 71.1 0.0 6.7e-20 70.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 KOO27966.1 - 0.0006 19.9 0.1 0.0046 17.1 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 KOO27966.1 - 0.00061 19.8 0.1 0.0095 16.0 0.0 2.2 1 1 1 2 2 2 1 Thioredoxin-like TraF PF13728.1 KOO27966.1 - 0.025 14.0 0.0 0.041 13.3 0.0 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_7 PF13899.1 KOO27966.1 - 0.039 13.9 0.0 0.074 13.0 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like DUF3450 PF11932.3 KOO27967.1 - 0.00054 19.3 3.9 0.00054 19.3 2.7 3.1 1 1 2 3 3 3 1 Protein of unknown function (DUF3450) TMF_TATA_bd PF12325.3 KOO27967.1 - 0.011 15.4 20.4 0.016 14.9 2.3 4.4 1 1 3 4 4 4 0 TATA element modulatory factor 1 TATA binding CENP-F_leu_zip PF10473.4 KOO27967.1 - 0.013 15.3 6.6 0.013 15.3 4.6 3.1 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cobalamin_bind PF01122.14 KOO27967.1 - 0.015 13.8 0.2 0.026 13.1 0.2 1.4 1 0 0 1 1 1 0 Eukaryotic cobalamin-binding protein DUF3584 PF12128.3 KOO27967.1 - 0.045 11.0 20.3 0.046 11.0 6.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) BAR_2 PF10455.4 KOO27967.1 - 0.097 11.5 8.7 0.012 14.5 2.8 1.7 2 0 0 2 2 2 0 Bin/amphiphysin/Rvs domain for vesicular trafficking FlaC_arch PF05377.6 KOO27967.1 - 0.12 12.2 7.6 8.8 6.3 0.1 4.2 3 1 0 4 4 4 0 Flagella accessory protein C (FlaC) BLOC1_2 PF10046.4 KOO27967.1 - 0.31 11.2 8.3 1.4 9.0 0.2 3.3 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4618 PF15397.1 KOO27967.1 - 0.63 9.3 14.3 0.023 14.0 5.0 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4618) AAA_13 PF13166.1 KOO27967.1 - 1.4 7.2 13.3 0.51 8.7 6.2 1.9 1 1 1 2 2 2 0 AAA domain CCDC-167 PF15188.1 KOO27967.1 - 1.5 8.8 14.7 0.2 11.6 3.1 3.5 2 1 2 4 4 4 0 Coiled-coil domain-containing protein 167 TBPIP PF07106.8 KOO27967.1 - 2.1 7.8 18.9 1.3 8.5 1.2 3.2 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Spc7 PF08317.6 KOO27967.1 - 2.4 6.7 16.4 0.5 8.9 5.5 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein TSC22 PF01166.13 KOO27967.1 - 2.8 7.9 8.8 15 5.6 0.1 4.3 5 1 0 5 5 4 0 TSC-22/dip/bun family Reo_sigmaC PF04582.7 KOO27967.1 - 5.2 6.1 9.1 8 5.5 1.2 2.9 1 1 2 3 3 3 0 Reovirus sigma C capsid protein COG2 PF06148.6 KOO27967.1 - 5.2 6.9 15.2 5.8 6.7 2.7 3.1 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 ADIP PF11559.3 KOO27967.1 - 6.4 6.6 17.5 0.45 10.4 6.9 2.7 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding TTL PF03133.10 KOO27968.1 - 3.8e-49 167.1 0.0 4.6e-36 124.2 0.0 2.1 1 1 1 2 2 2 2 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 KOO27968.1 - 1.2e-05 24.3 0.0 0.0035 16.1 0.0 2.2 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATP-grasp_4 PF13535.1 KOO27968.1 - 0.00098 18.8 0.0 0.0024 17.6 0.0 1.7 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.9 KOO27968.1 - 0.0066 16.3 0.0 0.32 10.8 0.0 2.2 2 0 0 2 2 2 1 ATP-grasp domain ATPgrasp_ST PF14397.1 KOO27968.1 - 0.039 13.0 0.0 3.9 6.4 0.0 2.1 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp RimK PF08443.6 KOO27968.1 - 0.16 11.3 0.0 1.4 8.3 0.0 2.0 2 0 0 2 2 2 0 RimK-like ATP-grasp domain Arm PF00514.18 KOO27969.1 - 4.3e-111 359.4 86.4 3.4e-06 26.6 0.1 26.0 27 0 0 27 27 27 22 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO27969.1 - 2.2e-38 130.3 58.8 4.2e-16 59.0 3.9 13.7 2 1 13 16 16 15 8 HEAT repeats Clathrin_H_link PF13838.1 KOO27969.1 - 4.5e-28 96.9 0.2 1.8e-27 95.0 0.1 2.2 1 0 0 1 1 1 1 Clathrin-H-link Clathrin_propel PF01394.15 KOO27969.1 - 2.1e-27 93.4 5.1 0.0015 18.7 0.0 7.7 7 0 0 7 7 7 6 Clathrin propeller repeat HEAT PF02985.17 KOO27969.1 - 5.8e-20 69.5 59.8 4.5e-05 23.1 0.1 14.8 18 0 0 18 18 14 7 HEAT repeat HEAT_EZ PF13513.1 KOO27969.1 - 2.5e-07 31.0 7.7 2.6e-06 27.7 1.8 15.2 10 5 7 17 17 16 6 HEAT-like repeat Clathrin-link PF09268.5 KOO27969.1 - 2.6e-07 29.5 0.0 5.2e-07 28.5 0.0 1.5 1 0 0 1 1 1 1 Clathrin, heavy-chain linker Cnd1 PF12717.2 KOO27969.1 - 3.8e-07 30.1 0.4 0.04 13.7 0.0 4.0 1 1 3 4 4 4 4 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.15 KOO27969.1 - 3.9e-07 28.7 7.4 0.00083 17.7 0.3 3.3 2 1 2 4 4 4 3 Adaptin N terminal region DUF2435 PF10363.4 KOO27969.1 - 3.8e-05 23.4 0.0 0.71 9.8 0.0 3.9 3 1 0 3 3 3 2 Protein of unknown function (DUF2435) WAPL PF07814.8 KOO27969.1 - 0.00012 20.9 0.0 49 2.4 0.0 7.1 5 4 4 9 9 9 0 Wings apart-like protein regulation of heterochromatin Arm_2 PF04826.8 KOO27969.1 - 0.00046 19.3 0.0 19 4.2 0.0 6.3 6 1 2 8 8 8 0 Armadillo-like Flg_hook PF02120.11 KOO27969.1 - 0.11 12.1 0.8 52 3.5 0.0 3.9 3 1 1 4 4 4 0 Flagellar hook-length control protein FliK VARLMGL PF14383.1 KOO27969.1 - 0.17 11.0 3.7 61 2.9 0.0 4.0 4 0 0 4 4 4 0 DUF761-associated sequence motif AAA_27 PF13514.1 KOO27970.1 - 0.46 8.0 9.9 0.59 7.7 6.9 1.0 1 0 0 1 1 1 0 AAA domain Exonuc_VIII PF06630.6 KOO27970.1 - 0.75 9.1 3.0 0.27 10.5 0.4 1.4 2 0 0 2 2 2 0 Enterobacterial exodeoxyribonuclease VIII Clathrin PF00637.15 KOO27971.1 - 1.5e-187 614.6 36.7 2.1e-29 101.9 0.8 7.7 8 0 0 8 8 8 7 Region in Clathrin and VPS MerR PF00376.18 KOO27971.1 - 0.038 13.5 0.0 0.078 12.5 0.0 1.6 1 0 0 1 1 1 0 MerR family regulatory protein SBP_bac_6 PF13343.1 KOO27971.1 - 0.069 12.4 0.7 2.6 7.2 0.0 2.7 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein TPR_1 PF00515.23 KOO27971.1 - 0.16 11.6 10.4 6 6.6 0.0 6.0 7 0 0 7 7 7 0 Tetratricopeptide repeat TruD PF01142.13 KOO27972.1 - 1.1e-47 162.5 0.0 6.1e-47 160.0 0.0 1.9 2 0 0 2 2 2 1 tRNA pseudouridine synthase D (TruD) LRR_1 PF00560.28 KOO27973.1 - 2.5e-07 29.7 0.1 3.7 7.9 0.0 4.8 4 0 0 4 4 4 3 Leucine Rich Repeat LRR_7 PF13504.1 KOO27973.1 - 1.4e-06 27.5 2.5 4.5 7.9 0.0 5.1 4 0 0 4 4 4 2 Leucine rich repeat LRR_6 PF13516.1 KOO27973.1 - 2.3e-06 27.0 1.5 5.5 7.3 0.0 5.8 7 0 0 7 7 7 2 Leucine Rich repeat LRR_4 PF12799.2 KOO27973.1 - 0.0003 20.3 0.0 1.5 8.5 0.0 3.0 2 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO27973.1 - 0.0038 16.9 0.1 0.66 9.7 0.0 3.1 1 1 2 3 3 3 2 Leucine rich repeat RCC1_2 PF13540.1 KOO27974.1 - 4.9e-10 38.7 25.5 0.0024 17.4 0.1 6.3 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat F-box-like PF12937.2 KOO27974.1 - 5.4e-09 35.6 0.1 1.6e-08 34.1 0.1 1.8 1 0 0 1 1 1 1 F-box-like RCC1 PF00415.13 KOO27974.1 - 7.6e-08 32.4 26.0 0.00027 21.0 0.0 8.0 7 2 0 7 7 7 3 Regulator of chromosome condensation (RCC1) repeat F-box PF00646.28 KOO27974.1 - 7.2e-06 25.5 2.1 1.2e-05 24.8 0.0 2.5 2 0 0 2 2 2 1 F-box domain DEAD PF00270.24 KOO27974.1 - 0.0049 16.3 0.0 0.032 13.7 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase PhoH PF02562.11 KOO27974.1 - 0.006 15.8 0.0 0.011 14.9 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein UvrD-helicase PF00580.16 KOO27974.1 - 0.0075 15.6 0.2 0.046 13.0 0.0 2.0 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain ResIII PF04851.10 KOO27974.1 - 0.016 15.0 0.0 1.7 8.4 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_10 PF12846.2 KOO27974.1 - 0.024 14.0 0.0 0.19 11.1 0.0 2.4 2 0 0 2 2 2 0 AAA-like domain PSD5 PF07637.6 KOO27974.1 - 0.32 11.0 4.8 1.4 9.0 0.5 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1595) NAD_binding_5 PF07994.7 KOO27975.1 - 1.6e-108 362.7 0.0 1.9e-108 362.4 0.0 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.12 KOO27975.1 - 1.1e-46 157.1 0.3 2.3e-46 156.2 0.2 1.5 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase DUF4496 PF14908.1 KOO27976.1 - 9.6e-26 90.3 0.0 1.7e-25 89.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4496) polyprenyl_synt PF00348.12 KOO27976.1 - 6.9e-22 77.5 0.0 1e-21 76.9 0.0 1.3 1 0 0 1 1 1 1 Polyprenyl synthetase Cyt-b5 PF00173.23 KOO27977.1 - 0.0039 16.9 0.0 0.0067 16.2 0.0 1.4 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain tRNA_anti-codon PF01336.20 KOO27977.1 - 0.15 11.9 0.0 0.47 10.3 0.0 1.9 1 1 0 1 1 1 0 OB-fold nucleic acid binding domain Ank_2 PF12796.2 KOO27978.1 - 4.2e-12 46.2 3.9 1.4e-06 28.5 0.7 3.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO27978.1 - 4.8e-09 36.4 0.4 0.006 17.0 0.0 3.4 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO27978.1 - 1.8e-08 34.3 1.6 0.0084 16.3 0.1 3.6 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO27978.1 - 2.4e-08 33.3 16.6 0.00045 19.8 0.1 4.8 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.1 KOO27978.1 - 3.8e-05 23.5 6.9 0.27 11.6 0.1 4.6 5 0 0 5 5 5 2 Ankyrin repeat DUF849 PF05853.7 KOO27978.1 - 0.096 11.5 0.1 0.15 10.9 0.1 1.3 1 0 0 1 1 1 0 Prokaryotic protein of unknown function (DUF849) Lipoprotein_15 PF03640.10 KOO27979.1 - 0.0019 17.5 0.8 0.0045 16.3 0.5 1.6 1 0 0 1 1 1 1 Secreted repeat of unknown function Histone PF00125.19 KOO27980.1 - 1.7e-14 53.6 0.2 2.1e-14 53.4 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 KOO27980.1 - 2.9e-05 24.1 0.1 3.9e-05 23.7 0.1 1.3 1 1 0 1 1 1 1 Kinetochore component CENP-S TAF PF02969.12 KOO27980.1 - 0.0002 21.2 0.2 0.00028 20.7 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.18 KOO27980.1 - 0.00049 20.0 0.1 0.0008 19.4 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 KOO27980.1 - 0.0061 16.2 0.0 0.0085 15.7 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.10 KOO27980.1 - 0.034 13.9 0.0 0.041 13.6 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit CENP-T PF15511.1 KOO27980.1 - 0.035 13.3 0.0 0.035 13.3 0.0 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T EF-hand_1 PF00036.27 KOO27982.1 - 0.0022 17.1 0.1 0.014 14.6 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.1 KOO27982.1 - 0.004 16.4 0.0 0.011 14.9 0.0 1.7 1 0 0 1 1 1 1 EF hand DUF2475 PF10629.4 KOO27982.1 - 0.0046 17.1 3.1 0.84 9.9 0.7 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF2475) EF-hand_6 PF13405.1 KOO27982.1 - 0.098 12.5 0.1 0.41 10.6 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain ubiquitin PF00240.18 KOO27983.1 - 0.0012 18.2 0.0 0.0016 17.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family ELM2 PF01448.19 KOO27985.1 - 0.00026 21.5 0.0 0.0017 18.9 0.0 2.4 1 1 0 1 1 1 1 ELM2 domain zf-RanBP PF00641.13 KOO27986.1 - 1.6e-08 33.4 3.3 1.6e-08 33.4 2.3 2.3 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others Pentapeptide_4 PF13599.1 KOO27988.1 - 1.9e-08 33.9 0.0 2.9 7.7 0.0 7.7 4 2 6 10 10 10 3 Pentapeptide repeats (9 copies) XK-related PF09815.4 KOO27988.1 - 0.00038 19.5 7.4 0.00089 18.3 5.2 1.5 1 1 0 1 1 1 1 XK-related protein DUF4032 PF13224.1 KOO27988.1 - 0.017 14.7 0.0 0.73 9.5 0.0 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4032) Aa_trans PF01490.13 KOO27991.1 - 1.3e-23 83.2 7.9 3.1e-23 81.9 5.5 1.5 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein FHA PF00498.21 KOO27992.1 - 1e-28 99.2 0.1 1.4e-14 53.9 0.0 2.3 2 0 0 2 2 2 2 FHA domain Arm PF00514.18 KOO27993.1 - 0.00069 19.3 6.4 4.7 7.1 0.1 6.1 5 2 1 6 6 6 2 Armadillo/beta-catenin-like repeat HEAT PF02985.17 KOO27993.1 - 6.7 7.0 7.1 12 6.2 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat Pkinase PF00069.20 KOO27994.1 - 4.1e-65 219.4 0.0 1.8e-64 217.4 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO27994.1 - 2.3e-25 89.1 0.1 2e-20 72.9 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 KOO27994.1 - 3.2e-05 23.0 0.1 0.00014 20.8 0.1 2.1 2 1 0 2 2 2 1 Kinase-like APH PF01636.18 KOO27994.1 - 0.0096 15.6 0.1 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family UCH PF00443.24 KOO27995.1 - 1e-13 51.0 0.0 1.6e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.18 KOO27995.1 - 5.9e-08 32.0 0.0 1.1e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.26 KOO27995.1 - 0.00042 20.0 0.1 0.0018 18.0 0.1 2.2 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.3 KOO27995.1 - 0.14 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like CENP-U PF13097.1 KOO27995.1 - 0.25 11.2 2.4 0.69 9.8 1.6 1.7 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit Homeobox PF00046.24 KOO27997.1 - 6.4e-14 51.3 0.9 1.6e-13 50.0 0.3 1.9 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.6 KOO27997.1 - 4.6e-05 23.0 0.0 0.00014 21.5 0.0 1.8 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.3 KOO27997.1 - 0.092 11.8 0.0 0.19 10.8 0.0 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez SHOCT PF09851.4 KOO27997.1 - 0.29 10.6 2.8 0.22 11.0 0.2 2.0 2 0 0 2 2 2 0 Short C-terminal domain LON PF02190.11 KOO27998.1 - 0.00024 20.8 0.0 0.004 16.8 0.0 2.0 2 0 0 2 2 2 2 ATP-dependent protease La (LON) domain HAD_2 PF13419.1 KOO27999.1 - 0.0012 19.0 0.0 0.0021 18.3 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase DUF1311 PF07007.7 KOO28000.1 - 0.0019 18.2 1.2 0.0027 17.7 0.6 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1311) MgsA_C PF12002.3 KOO28000.1 - 0.018 14.7 0.1 0.021 14.4 0.1 1.2 1 0 0 1 1 1 0 MgsA AAA+ ATPase C terminal EF-hand_5 PF13202.1 KOO28001.1 - 5.4e-06 25.5 0.2 1.2e-05 24.3 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KOO28001.1 - 2.3e-05 23.3 0.1 4.5e-05 22.4 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO28001.1 - 0.0012 18.5 0.0 0.0028 17.4 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 KOO28001.1 - 0.0085 16.2 0.0 0.016 15.3 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair Chloroa_b-bind PF00504.16 KOO28002.1 - 7e-29 101.1 0.1 9.3e-29 100.6 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Ion_trans PF00520.26 KOO28003.1 - 4.9e-64 215.2 26.6 2.2e-40 138.0 6.3 2.3 2 0 0 2 2 2 2 Ion transport protein Ctr PF04145.10 KOO28003.1 - 0.088 12.8 5.4 1.2 9.1 3.4 2.5 1 1 0 1 1 1 0 Ctr copper transporter family ABC1 PF03109.11 KOO28004.1 - 9.4e-20 70.7 0.5 3.7e-09 36.6 0.1 2.4 2 0 0 2 2 2 2 ABC1 family Beta-lactamase PF00144.19 KOO28004.1 - 5.4e-16 58.5 0.1 2e-15 56.6 0.1 1.9 1 1 0 1 1 1 1 Beta-lactamase SCP2 PF02036.12 KOO28004.1 - 5.2e-07 29.8 0.0 1.2e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 SCP-2 sterol transfer family PX PF00787.19 KOO28004.1 - 2.1e-06 27.5 0.0 3.5e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 PX domain Alkyl_sulf_C PF14864.1 KOO28004.1 - 0.02 14.8 0.0 0.046 13.6 0.0 1.6 1 0 0 1 1 1 0 Alkyl sulfatase C-terminal Flg_hook PF02120.11 KOO28004.1 - 0.054 13.1 0.1 0.14 11.8 0.1 1.6 1 0 0 1 1 1 0 Flagellar hook-length control protein FliK LRR_6 PF13516.1 KOO28005.1 - 5.7e-38 124.7 8.8 0.00012 21.8 0.0 8.9 9 0 0 9 9 9 7 Leucine Rich repeat LRR_4 PF12799.2 KOO28005.1 - 8.9e-08 31.5 0.6 0.29 10.7 0.0 5.3 3 1 4 7 7 7 3 Leucine Rich repeats (2 copies) BRCT PF00533.21 KOO28005.1 - 1.3e-07 31.6 0.0 3.1e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LRR_1 PF00560.28 KOO28005.1 - 0.0017 18.0 0.0 1.6e+02 2.9 0.0 6.3 9 0 0 9 9 9 0 Leucine Rich Repeat LRR_8 PF13855.1 KOO28005.1 - 0.0028 17.3 1.8 15 5.4 0.1 5.0 3 1 3 6 6 6 0 Leucine rich repeat HR1 PF02185.11 KOO28005.1 - 0.011 15.5 0.3 0.026 14.2 0.2 1.6 1 0 0 1 1 1 0 Hr1 repeat Cob_adeno_trans PF01923.13 KOO28005.1 - 0.025 14.3 2.2 0.055 13.2 1.5 1.5 1 0 0 1 1 1 0 Cobalamin adenosyltransferase Viral_P18 PF04521.8 KOO28005.1 - 0.13 11.7 1.8 0.36 10.2 1.2 1.7 1 0 0 1 1 1 0 ssRNA positive strand viral 18kD cysteine rich protein DUF4404 PF14357.1 KOO28005.1 - 0.4 11.1 4.5 1.2 9.5 3.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) LRR_7 PF13504.1 KOO28005.1 - 1.6 9.2 9.5 3.6e+02 2.1 0.0 6.9 8 0 0 8 8 8 0 Leucine rich repeat Fea1 PF07692.6 KOO28007.1 - 1.5e-15 56.9 0.1 7.1e-15 54.6 0.1 2.0 1 1 0 1 1 1 1 Low iron-inducible periplasmic protein EF-hand_1 PF00036.27 KOO28008.1 - 2.7e-23 79.4 8.8 3.1e-08 32.3 0.0 4.8 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.1 KOO28008.1 - 2.7e-19 69.0 1.2 1.6e-10 40.9 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO28008.1 - 1.7e-16 59.5 4.8 1.2e-07 31.2 0.1 3.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO28008.1 - 1.5e-15 55.6 8.8 0.00032 20.3 0.1 4.9 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.1 KOO28008.1 - 2.6e-14 51.7 0.7 9.6e-05 21.5 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_4 PF12763.2 KOO28008.1 - 1e-06 28.3 1.3 0.015 15.0 0.0 3.2 3 1 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO28008.1 - 1.3e-06 28.2 0.2 0.038 13.9 0.0 2.7 3 0 0 3 3 3 2 EF-hand domain TerB PF05099.8 KOO28008.1 - 0.0053 16.4 0.0 0.28 10.9 0.0 2.5 2 0 0 2 2 2 1 Tellurite resistance protein TerB HTH_26 PF13443.1 KOO28008.1 - 0.038 14.1 0.1 2.3 8.5 0.0 2.5 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain EF-hand_10 PF14788.1 KOO28008.1 - 0.14 11.8 0.2 13 5.4 0.0 3.0 3 0 0 3 3 3 0 EF hand Ion_trans PF00520.26 KOO28009.1 - 3.4e-80 268.0 8.9 9.2e-37 126.2 3.1 4.2 3 1 1 4 4 4 4 Ion transport protein Pentapeptide_4 PF13599.1 KOO28009.1 - 0.093 12.5 0.0 0.36 10.6 0.0 1.9 2 0 0 2 2 2 0 Pentapeptide repeats (9 copies) APG6 PF04111.7 KOO28010.1 - 0.27 10.2 22.0 0.12 11.3 11.2 2.2 1 1 1 2 2 2 0 Autophagy protein Apg6 DUF1788 PF08747.6 KOO28010.1 - 0.3 10.9 1.2 0.62 9.9 0.3 1.8 1 1 0 2 2 2 0 Domain of unknown function (DUF1788) AAA_13 PF13166.1 KOO28010.1 - 4.1 5.7 7.2 5.7 5.2 5.0 1.2 1 0 0 1 1 1 0 AAA domain GAS PF13851.1 KOO28010.1 - 4.5 6.4 15.6 1.5 7.9 3.1 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Atg14 PF10186.4 KOO28010.1 - 5.6 5.8 17.8 0.65 8.8 8.6 1.9 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Borrelia_P83 PF05262.6 KOO28010.1 - 6.1 5.0 12.5 4.4 5.4 7.4 1.5 1 1 0 1 1 1 0 Borrelia P83/100 protein Sec2p PF06428.6 KOO28013.1 - 0.03 14.1 1.7 0.03 14.1 1.1 2.2 1 1 0 2 2 2 0 GDP/GTP exchange factor Sec2p Laminin_II PF06009.7 KOO28013.1 - 0.035 13.8 1.9 0.059 13.1 1.3 1.4 1 0 0 1 1 1 0 Laminin Domain II ATP-synt_D PF01813.12 KOO28013.1 - 0.041 13.4 6.1 0.053 13.0 4.2 1.1 1 0 0 1 1 1 0 ATP synthase subunit D Atg14 PF10186.4 KOO28013.1 - 0.055 12.4 7.6 0.068 12.1 5.3 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Ded_cyto PF06920.8 KOO28013.1 - 0.33 10.2 2.0 0.66 9.2 1.4 1.5 1 1 0 1 1 1 0 Dedicator of cytokinesis Spc24 PF08286.6 KOO28013.1 - 0.81 9.3 4.9 4.3 7.0 0.4 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 ATP-synt_B PF00430.13 KOO28013.1 - 4.7 7.0 11.5 9 6.1 8.0 1.5 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) ART PF01129.13 KOO28014.1 - 6.4e-05 22.1 0.0 0.00017 20.7 0.0 1.6 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase LRR_6 PF13516.1 KOO28014.1 - 0.00056 19.7 0.1 0.0062 16.4 0.0 2.7 2 0 0 2 2 2 1 Leucine Rich repeat DUF4407 PF14362.1 KOO28014.1 - 0.01 14.8 9.4 0.025 13.5 6.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1501 PF07394.7 KOO28014.1 - 0.041 12.7 5.2 0.072 11.9 2.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1501) GAS PF13851.1 KOO28014.1 - 2.8 7.1 11.0 3.4 6.8 0.2 2.6 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Ank PF00023.25 KOO28015.1 - 1.6e-23 81.2 0.4 3e-09 36.2 0.0 4.4 4 0 0 4 4 4 4 Ankyrin repeat Ank_2 PF12796.2 KOO28015.1 - 5.9e-23 81.0 1.0 2.1e-11 44.0 0.1 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO28015.1 - 2.7e-17 62.7 0.1 9.6e-10 38.7 0.1 3.2 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO28015.1 - 1.4e-16 60.1 0.2 1.3e-09 38.0 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO28015.1 - 3.5e-15 54.5 0.0 1.7e-05 24.6 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat DUF2384 PF09722.5 KOO28015.1 - 0.026 14.3 0.0 0.073 12.9 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2384) Med3 PF11593.3 KOO28015.1 - 0.5 9.5 8.6 0.58 9.3 5.9 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal KH_1 PF00013.24 KOO28016.1 - 7.3e-21 73.5 0.0 2.5e-10 39.8 0.0 2.2 2 0 0 2 2 2 2 KH domain KH_3 PF13014.1 KOO28016.1 - 1e-15 56.9 0.1 3.3e-07 29.8 0.0 2.3 2 0 0 2 2 2 2 KH domain KH_2 PF07650.12 KOO28016.1 - 5.3e-06 25.8 0.0 0.002 17.6 0.0 2.2 2 0 0 2 2 2 2 KH domain KH_4 PF13083.1 KOO28016.1 - 6.2e-05 22.5 0.1 0.38 10.4 0.0 2.3 2 0 0 2 2 2 2 KH domain Methyltransf_26 PF13659.1 KOO28016.1 - 0.71 9.9 5.7 3.6 7.6 3.9 2.3 1 1 0 1 1 1 0 Methyltransferase domain G-patch PF01585.18 KOO28017.1 - 2.9e-05 23.7 2.7 6.9e-05 22.5 1.8 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 KOO28017.1 - 0.00028 20.6 0.1 0.00075 19.3 0.0 1.8 1 0 0 1 1 1 1 DExH-box splicing factor binding site DUF3486 PF11985.3 KOO28017.1 - 9 6.3 9.7 0.12 12.3 0.6 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3486) Mito_carr PF00153.22 KOO28018.1 - 4.5e-63 208.9 2.4 5.1e-20 70.9 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_5 PF13202.1 KOO28019.1 - 5.9e-09 34.8 0.2 3.7e-05 22.8 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO28019.1 - 1.4e-08 34.2 0.2 3.9e-08 32.7 0.0 1.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO28019.1 - 2.8e-08 32.9 0.0 2.8e-05 23.6 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO28019.1 - 6.6e-08 32.5 0.2 1.5e-07 31.4 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO28019.1 - 1.3e-07 30.3 0.1 1.8e-05 23.6 0.0 2.4 2 0 0 2 2 2 1 EF hand SHIPPO-rpt PF07004.7 KOO28019.1 - 0.0035 18.1 1.8 0.13 13.2 0.1 2.8 2 0 0 2 2 2 1 Sperm-tail PG-rich repeat Ras PF00071.17 KOO28020.1 - 3e-53 179.5 0.3 1.1e-52 177.6 0.2 1.7 1 1 0 1 1 1 1 Ras family Miro PF08477.8 KOO28020.1 - 3.8e-16 59.6 0.0 6.8e-16 58.8 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO28020.1 - 1.3e-07 31.0 0.1 5.4e-07 29.0 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 KOO28020.1 - 3.1e-05 23.8 0.0 5.3e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 KOO28020.1 - 0.0011 19.1 0.0 0.0043 17.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain GTP_EFTU PF00009.22 KOO28020.1 - 0.0024 17.3 0.1 0.057 12.8 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 KOO28020.1 - 0.003 16.7 0.1 0.0088 15.2 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_24 PF13479.1 KOO28020.1 - 0.041 13.4 0.0 0.07 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 KOO28020.1 - 0.041 13.8 0.1 0.14 12.1 0.1 2.0 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.22 KOO28020.1 - 0.044 14.0 0.0 0.082 13.2 0.0 1.4 1 0 0 1 1 1 0 ABC transporter FeoB_N PF02421.13 KOO28020.1 - 0.069 12.4 0.2 0.85 8.8 0.0 2.0 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_15 PF13175.1 KOO28020.1 - 0.11 11.4 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Cation_efflux PF01545.16 KOO28021.1 - 2e-59 201.0 8.5 1.8e-54 184.7 3.3 2.0 2 0 0 2 2 2 2 Cation efflux family HisG_C PF08029.6 KOO28021.1 - 0.07 13.0 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 HisG, C-terminal domain AsnC_trans_reg PF01037.16 KOO28021.1 - 0.21 11.3 1.9 1.1 8.9 0.2 2.3 2 0 0 2 2 2 0 AsnC family DUF4282 PF14110.1 KOO28021.1 - 7.7 6.7 8.7 0.59 10.3 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4282) Mito_carr PF00153.22 KOO28024.1 - 1.2e-27 95.4 3.4 1.8e-13 49.9 0.0 4.1 4 0 0 4 4 4 4 Mitochondrial carrier protein Proteasome PF00227.21 KOO28025.1 - 4.7e-59 198.8 0.1 8.1e-59 198.1 0.0 1.4 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.4 KOO28025.1 - 5.4e-11 41.5 0.1 5.4e-11 41.5 0.1 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature TPR_11 PF13414.1 KOO28026.1 - 1.5e-11 43.7 11.1 1.6e-07 30.9 0.9 4.0 2 2 1 3 3 3 3 TPR repeat TPR_1 PF00515.23 KOO28026.1 - 0.0063 16.0 16.8 0.0078 15.7 0.7 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO28026.1 - 0.0075 16.1 9.9 0.095 12.6 0.8 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat MIT PF04212.13 KOO28026.1 - 0.03 14.2 4.8 0.088 12.6 0.1 3.2 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain PdxJ PF03740.8 KOO28026.1 - 0.063 12.4 0.8 0.11 11.5 0.6 1.3 1 0 0 1 1 1 0 Pyridoxal phosphate biosynthesis protein PdxJ TPR_16 PF13432.1 KOO28026.1 - 0.075 13.7 17.9 3 8.6 0.2 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOO28026.1 - 0.1 12.4 2.6 1.1 9.1 0.4 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28026.1 - 4.5 8.1 16.5 0.23 12.1 1.5 4.8 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO28026.1 - 4.7 7.2 6.1 2.5 8.1 0.0 3.6 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO28026.1 - 7.7 7.2 6.6 7.5 7.2 0.1 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat Pkinase PF00069.20 KOO28027.1 - 6.8e-51 172.9 0.0 9.5e-51 172.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO28027.1 - 1.7e-42 145.2 0.0 2.3e-42 144.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO28027.1 - 0.062 13.0 0.0 0.25 11.0 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO28027.1 - 0.13 11.2 0.0 0.21 10.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like HNH PF01844.18 KOO28028.1 - 0.0035 17.1 0.0 0.0056 16.5 0.0 1.3 1 0 0 1 1 1 1 HNH endonuclease DNA_topoisoIV PF00521.15 KOO28029.1 - 7.3e-21 74.5 0.0 1.1e-20 73.9 0.0 1.2 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A SAP PF02037.22 KOO28029.1 - 1.2e-12 46.9 0.2 2.4e-12 46.0 0.1 1.5 1 0 0 1 1 1 1 SAP domain Toprim PF01751.17 KOO28029.1 - 6.2e-10 38.9 0.0 1.1e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 Toprim domain DNA_gyraseB PF00204.20 KOO28029.1 - 1e-09 37.8 0.0 1.8e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.21 KOO28029.1 - 1.4e-08 34.3 0.0 2.6e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HeH PF12949.2 KOO28029.1 - 0.0053 16.2 0.0 0.013 15.0 0.0 1.7 1 0 0 1 1 1 1 HeH/LEM domain HATPase_c_3 PF13589.1 KOO28029.1 - 0.0062 16.1 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PNRC PF15365.1 KOO28030.1 - 0.2 11.7 8.9 1 9.4 0.2 3.3 3 0 0 3 3 3 0 Proline-rich nuclear receptor coactivator Pkinase PF00069.20 KOO28031.1 - 2.1e-51 174.5 0.0 2.9e-51 174.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO28031.1 - 1.7e-44 151.8 0.0 2.8e-44 151.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO28031.1 - 0.0041 16.8 0.1 0.12 12.0 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO28031.1 - 0.016 14.1 0.0 0.026 13.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.9 KOO28031.1 - 0.12 11.4 0.0 0.22 10.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-C3HC4_3 PF13920.1 KOO28032.1 - 1.1e-12 47.3 9.8 1.7e-12 46.7 6.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO28032.1 - 6.2e-09 35.7 10.0 1.1e-08 34.9 7.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO28032.1 - 1.1e-05 24.9 8.2 1.9e-05 24.2 5.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO28032.1 - 6.2e-05 22.7 10.0 0.0001 22.0 6.9 1.4 1 0 0 1 1 1 1 Ring finger domain Pkinase PF00069.20 KOO28032.1 - 0.00077 18.6 0.0 0.0011 18.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain zf-RING_5 PF14634.1 KOO28032.1 - 0.0057 16.3 9.4 0.0095 15.6 6.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Baculo_IE-1 PF05290.6 KOO28032.1 - 0.37 10.5 2.5 0.57 9.9 1.7 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Prok-RING_4 PF14447.1 KOO28032.1 - 2 8.0 9.6 20 4.8 6.7 2.1 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 SdiA-regulated PF06977.6 KOO28033.1 - 3.2e-24 85.2 0.0 2.6e-23 82.2 0.0 2.3 1 1 0 1 1 1 1 SdiA-regulated LTD PF00932.14 KOO28033.1 - 4.6e-16 58.9 0.0 9.6e-09 35.3 0.0 2.8 3 0 0 3 3 3 2 Lamin Tail Domain Phytase-like PF13449.1 KOO28033.1 - 0.098 11.9 0.0 4.2 6.5 0.0 2.2 2 0 0 2 2 2 0 Esterase-like activity of phytase SGL PF08450.7 KOO28033.1 - 0.099 12.0 0.0 6.7 6.0 0.0 2.9 2 1 1 3 3 3 0 SMP-30/Gluconolaconase/LRE-like region Nol1_Nop2_Fmu PF01189.12 KOO28034.1 - 1.3e-15 57.5 0.0 1.8e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 NOL1/NOP2/sun family Cyt-b5 PF00173.23 KOO28034.1 - 1e-12 47.6 0.0 1.9e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain F-box-like_2 PF13013.1 KOO28034.1 - 0.00073 19.2 0.0 0.0022 17.6 0.0 1.7 2 0 0 2 2 2 1 F-box-like domain F-box-like PF12937.2 KOO28034.1 - 0.0033 17.1 0.1 0.0059 16.3 0.1 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 KOO28034.1 - 0.008 15.8 0.1 0.013 15.1 0.1 1.4 1 0 0 1 1 1 1 F-box domain PAT1 PF09770.4 KOO28036.1 - 0.71 8.0 6.0 0.83 7.8 4.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TPD PF14811.1 KOO28037.1 - 1.7e-42 144.2 0.0 3.8e-41 139.8 0.0 2.0 2 0 0 2 2 2 2 Protein of unknown function TPD sequence-motif AMMECR1 PF01871.12 KOO28038.1 - 1.2e-36 125.3 0.0 1.7e-36 124.9 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 RRM_1 PF00076.17 KOO28039.1 - 2.4e-18 65.5 0.0 3.4e-18 65.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO28039.1 - 1.6e-14 53.6 0.0 2.3e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO28039.1 - 0.00095 18.9 0.0 0.0014 18.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.1 KOO28039.1 - 0.0062 15.8 8.9 0.0082 15.4 6.2 1.2 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal MDMPI_N PF11716.3 KOO28039.1 - 0.047 14.1 0.3 0.051 13.9 0.2 1.1 1 0 0 1 1 1 0 Mycothiol maleylpyruvate isomerase N-terminal domain DUF4414 PF14377.1 KOO28039.1 - 0.062 13.2 1.2 0.12 12.3 0.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4414) FtsJ PF01728.14 KOO28040.1 - 1.3e-10 41.5 0.0 2e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Galactosyl_T PF01762.16 KOO28041.1 - 1.2e-08 34.8 0.0 0.0053 16.3 0.0 2.5 2 1 0 2 2 2 2 Galactosyltransferase Amino_oxidase PF01593.19 KOO28044.1 - 2.4e-65 221.3 1.0 5.1e-65 220.3 0.7 1.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 KOO28044.1 - 4e-08 33.1 0.0 1.1e-07 31.7 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 KOO28044.1 - 0.00017 21.3 0.1 0.0011 18.7 0.0 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 KOO28044.1 - 0.00093 19.3 0.1 0.031 14.3 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 KOO28044.1 - 0.0069 15.5 0.2 0.013 14.6 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.9 KOO28044.1 - 0.036 13.9 0.8 0.17 11.7 0.5 2.2 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.16 KOO28044.1 - 0.051 13.1 1.3 0.11 12.0 0.9 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.22 KOO28044.1 - 0.051 13.9 0.1 0.26 11.7 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MAD PF05557.8 KOO28045.1 - 0.0031 15.6 2.3 0.0038 15.3 1.6 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein Phage_HK97_TLTM PF06120.6 KOO28045.1 - 0.033 13.5 0.4 0.041 13.2 0.3 1.1 1 0 0 1 1 1 0 Tail length tape measure protein HALZ PF02183.13 KOO28045.1 - 0.066 12.9 0.1 2.4 7.9 0.0 2.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper bZIP_1 PF00170.16 KOO28045.1 - 0.071 13.0 0.3 1.4 8.9 0.0 2.7 2 1 1 3 3 3 0 bZIP transcription factor BRE1 PF08647.6 KOO28045.1 - 0.075 13.0 0.6 0.21 11.5 0.2 1.8 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase MbeD_MobD PF04899.7 KOO28045.1 - 0.18 11.7 2.6 1.1 9.2 0.5 2.3 1 1 0 2 2 2 0 MbeD/MobD like FliT PF05400.8 KOO28045.1 - 0.26 11.7 2.4 1.7 9.0 0.0 2.4 2 1 0 2 2 2 0 Flagellar protein FliT DUF498 PF04430.9 KOO28046.1 - 0.067 12.7 2.4 3.2 7.3 0.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF498/DUF598) CbbQ_C PF08406.5 KOO28047.1 - 0.12 12.4 3.3 0.72 9.8 0.1 2.9 2 1 1 3 3 3 0 CbbQ/NirQ/NorQ C-terminal DUF972 PF06156.8 KOO28047.1 - 0.58 10.5 2.7 0.97 9.8 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF972) UVR PF02151.14 KOO28048.1 - 5e-13 48.0 8.1 1.2e-06 27.8 1.7 2.5 2 0 0 2 2 2 2 UvrB/uvrC motif DUF2084 PF09857.4 KOO28049.1 - 0.0045 16.6 0.0 0.011 15.4 0.0 1.5 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2084) PMT PF02366.13 KOO28051.1 - 6e-34 117.4 0.1 7.5e-34 117.1 0.1 1.0 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase LCM PF04072.9 KOO28051.1 - 0.12 11.9 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Leucine carboxyl methyltransferase Pentapeptide_4 PF13599.1 KOO28052.1 - 2.4e-47 158.6 0.0 1.1e-07 31.5 0.0 9.6 4 3 5 9 9 9 9 Pentapeptide repeats (9 copies) EF-hand_1 PF00036.27 KOO28052.1 - 2.8e-06 26.2 1.1 1.4e-05 24.0 0.4 2.6 2 0 0 2 2 2 1 EF hand UBA PF00627.26 KOO28052.1 - 0.00066 19.4 0.5 45 4.0 0.0 7.1 8 0 0 8 8 7 0 UBA/TS-N domain XK-related PF09815.4 KOO28052.1 - 0.0022 17.0 7.5 0.01 14.8 5.1 1.8 1 1 0 1 1 1 1 XK-related protein CPSase_L_D3 PF02787.14 KOO28052.1 - 0.0054 16.5 2.3 2.4 7.9 0.0 4.9 4 2 2 6 6 6 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain EF-hand_6 PF13405.1 KOO28052.1 - 0.012 15.4 0.1 0.14 12.0 0.0 2.9 2 0 0 2 2 2 0 EF-hand domain HTH_20 PF12840.2 KOO28052.1 - 0.02 14.7 2.5 4.5 7.1 0.0 6.1 6 0 0 6 6 6 0 Helix-turn-helix domain TFIIE_alpha PF02002.12 KOO28052.1 - 0.025 14.0 0.0 0.29 10.6 0.0 2.7 2 0 0 2 2 2 0 TFIIE alpha subunit EF-hand_8 PF13833.1 KOO28052.1 - 0.026 14.1 0.4 0.46 10.1 0.1 3.1 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.1 KOO28052.1 - 0.028 13.7 3.2 0.1 12.0 0.4 3.3 3 0 0 3 3 3 0 EF hand EF-hand_7 PF13499.1 KOO28052.1 - 0.11 12.6 0.1 0.56 10.3 0.0 2.3 1 0 0 1 1 1 0 EF-hand domain pair Pentapeptide PF00805.17 KOO28052.1 - 0.15 11.2 2.1 17 4.7 0.0 3.6 3 0 0 3 3 3 0 Pentapeptide repeats (8 copies) Cna_B PF05738.8 KOO28052.1 - 0.17 11.6 0.1 2.6 7.8 0.0 2.7 2 0 0 2 2 2 0 Cna protein B-type domain Ribosomal_L13e PF01294.13 KOO28052.1 - 6 6.2 11.9 9.9 5.5 0.1 6.7 6 6 3 10 10 10 0 Ribosomal protein L13e MFS_1 PF07690.11 KOO28053.1 - 2.5e-27 95.5 79.0 1.5e-24 86.3 30.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.2 KOO28053.1 - 0.22 11.3 4.4 2.5 7.9 0.1 2.9 3 0 0 3 3 3 0 MFS_1 like family DUF3149 PF11346.3 KOO28053.1 - 1.7 8.2 4.5 4.7 6.8 3.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) Arm PF00514.18 KOO28054.1 - 1.4e-104 338.7 99.3 3.7e-07 29.7 0.2 29.6 29 1 1 30 30 30 23 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 KOO28054.1 - 4.7e-12 45.5 7.8 0.1 11.6 0.1 8.5 6 2 5 11 11 11 4 Armadillo-like Atx10homo_assoc PF09759.4 KOO28054.1 - 4e-11 42.5 0.3 0.53 10.0 0.0 7.1 6 1 1 7 7 7 4 Spinocerebellar ataxia type 10 protein domain Adaptin_N PF01602.15 KOO28054.1 - 2e-07 29.7 4.2 0.7 8.1 0.1 5.8 3 3 2 5 5 5 3 Adaptin N terminal region V-ATPase_H_N PF03224.9 KOO28054.1 - 1.4e-05 24.3 2.7 0.78 8.8 0.0 5.1 4 3 0 4 4 4 2 V-ATPase subunit H V-ATPase_H_C PF11698.3 KOO28054.1 - 0.0036 17.2 1.3 0.9 9.4 0.0 4.0 3 0 0 3 3 3 1 V-ATPase subunit H DUF2803 PF10972.3 KOO28054.1 - 0.081 12.4 1.3 0.23 10.9 0.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2803) HEAT PF02985.17 KOO28054.1 - 4.2 7.7 36.7 21 5.5 0.0 13.2 15 0 0 15 15 15 0 HEAT repeat TPR_12 PF13424.1 KOO28055.1 - 2.8e-07 30.3 11.3 0.0053 16.6 0.7 5.0 3 1 2 5 5 5 4 Tetratricopeptide repeat NACHT PF05729.7 KOO28055.1 - 5.8e-07 29.3 0.1 1.2e-05 25.0 0.0 2.9 2 0 0 2 2 2 1 NACHT domain TPR_11 PF13414.1 KOO28055.1 - 2.5e-06 27.0 5.7 0.00044 19.8 0.4 3.9 3 0 0 3 3 3 2 TPR repeat DUF4062 PF13271.1 KOO28055.1 - 0.0013 18.7 0.9 0.015 15.2 0.2 2.9 2 1 0 2 2 2 1 Domain of unknown function (DUF4062) AAA_22 PF13401.1 KOO28055.1 - 0.0024 17.9 0.0 0.026 14.6 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KOO28055.1 - 0.0068 16.4 5.3 0.013 15.4 0.2 3.9 3 1 0 3 3 3 1 AAA ATPase domain TPR_7 PF13176.1 KOO28055.1 - 0.079 12.8 2.5 22 5.1 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Thioredoxin_8 PF13905.1 KOO28056.1 - 4.3e-06 26.7 0.0 6.6e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.16 KOO28056.1 - 1.9e-05 24.3 0.0 3.3e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 KOO28056.1 - 0.002 17.6 0.0 0.0029 17.1 0.0 1.3 1 0 0 1 1 1 1 Redoxin Thioredoxin_2 PF13098.1 KOO28056.1 - 0.0023 18.1 0.0 0.0037 17.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin PF00085.15 KOO28056.1 - 0.033 13.8 0.0 0.067 12.8 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin LON PF02190.11 KOO28057.1 - 2e-14 53.7 0.0 2.9e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 ATP-dependent protease La (LON) domain Thioesterase PF00975.15 KOO28057.1 - 5.7e-08 33.2 0.0 8.9e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain 2OG-FeII_Oxy_3 PF13640.1 KOO28058.1 - 1.9e-12 47.5 0.0 3.9e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Oxygenase-NA PF09859.4 KOO28058.1 - 8.8e-05 21.8 0.0 0.00081 18.7 0.0 2.3 2 1 0 2 2 2 1 Oxygenase, catalysing oxidative methylation of damaged DNA 2OG-FeII_Oxy_5 PF13759.1 KOO28058.1 - 0.0011 19.1 0.0 0.0064 16.7 0.0 2.2 2 1 0 2 2 2 1 Putative 2OG-Fe(II) oxygenase 2OG-FeII_Oxy_4 PF13661.1 KOO28058.1 - 0.0089 15.6 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_2 PF13532.1 KOO28058.1 - 0.023 14.5 0.0 0.026 14.3 0.0 1.2 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily PhyH PF05721.8 KOO28058.1 - 0.091 12.7 0.0 0.26 11.3 0.0 1.6 1 1 1 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) zf-CXXC PF02008.15 KOO28059.1 - 0.028 14.2 0.4 0.041 13.6 0.3 1.3 1 0 0 1 1 1 0 CXXC zinc finger domain Peptidase_C1 PF00112.18 KOO28060.1 - 4.2e-58 196.8 0.0 5.6e-58 196.4 0.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KOO28060.1 - 2.2e-06 27.8 0.0 3.2e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.10 KOO28060.1 - 0.00022 19.9 1.8 0.017 13.6 0.5 2.2 2 0 0 2 2 2 2 Peptidase C1-like family DEAD PF00270.24 KOO28061.1 - 1.5e-18 66.8 0.0 8.2e-17 61.2 0.0 2.1 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.10 KOO28061.1 - 0.0034 17.2 0.0 0.061 13.1 0.0 2.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 KOO28061.1 - 0.0041 17.2 0.1 0.0066 16.5 0.1 1.3 1 0 0 1 1 1 1 AAA domain DNA_pol_A PF00476.15 KOO28062.1 - 4.1e-61 206.7 0.0 5.7e-57 193.0 0.0 3.0 3 0 0 3 3 3 2 DNA polymerase family A DUF4196 PF13846.1 KOO28062.1 - 0.063 13.5 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4196) PEPcase PF00311.12 KOO28063.1 - 2.8e-238 792.7 0.0 3.3e-238 792.5 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxylase PEPcase_2 PF14010.1 KOO28063.1 - 1.5e-07 30.1 0.0 2.3e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxylase Methyltransf_24 PF13578.1 KOO28065.1 - 3.9e-05 24.4 0.1 6.9e-05 23.6 0.1 1.4 2 0 0 2 2 2 1 Methyltransferase domain MBOAT_2 PF13813.1 KOO28066.1 - 5.6e-11 42.3 2.0 1.2e-10 41.2 1.4 1.6 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family MBOAT PF03062.14 KOO28066.1 - 7.3e-06 25.3 0.5 1e-05 24.8 0.3 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family YrzO PF14142.1 KOO28066.1 - 0.31 10.7 1.5 0.98 9.1 0.1 2.2 2 0 0 2 2 2 0 YrzO-like protein SspN PF08177.6 KOO28068.1 - 0.0072 16.0 0.7 0.017 14.8 0.5 1.6 1 0 0 1 1 1 1 Small acid-soluble spore protein N family FliM PF02154.10 KOO28068.1 - 0.042 13.5 0.1 0.094 12.3 0.1 1.5 1 0 0 1 1 1 0 Flagellar motor switch protein FliM Sec3_C_2 PF15278.1 KOO28068.1 - 5.5 7.1 6.3 1.1 9.4 0.4 2.8 2 1 1 3 3 3 0 Sec3 exocyst complex subunit Pkinase PF00069.20 KOO28070.1 - 2.2e-37 128.5 0.0 3.5e-37 127.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO28070.1 - 1.1e-29 103.3 0.0 1.8e-29 102.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.2 KOO28070.1 - 1.3e-16 60.6 0.1 6.5e-09 36.0 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO28070.1 - 4.4e-14 51.4 1.3 3.8e-06 26.4 0.1 4.8 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.1 KOO28070.1 - 2.3e-12 47.0 1.2 2e-05 24.9 0.0 4.4 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO28070.1 - 6.1e-11 42.2 1.0 1e-07 31.9 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO28070.1 - 3.6e-06 26.6 1.2 0.0017 18.3 0.0 4.8 6 0 0 6 6 6 1 Ankyrin repeat Ank_4 PF13637.1 KOO28071.1 - 1.5e-16 60.4 0.9 3.8e-09 36.8 0.2 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO28071.1 - 5.8e-14 52.2 0.0 9.8e-14 51.4 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO28071.1 - 9.4e-12 44.1 0.0 2.5e-08 33.3 0.1 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 KOO28071.1 - 9.3e-10 38.4 0.5 3e-09 36.8 0.1 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO28071.1 - 2.6e-09 36.4 0.0 5.9e-06 26.0 0.1 3.1 3 0 0 3 3 3 2 Ankyrin repeat TerC PF03741.11 KOO28072.1 - 2.7e-43 147.5 2.6 4.5e-43 146.8 1.8 1.3 1 0 0 1 1 1 1 Integral membrane protein TerC family EF-hand_8 PF13833.1 KOO28072.1 - 0.0003 20.3 0.0 0.00083 18.9 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO28072.1 - 0.017 14.9 0.0 0.052 13.4 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.1 KOO28072.1 - 0.023 14.8 0.0 0.044 13.9 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.27 KOO28072.1 - 0.097 12.0 0.0 0.2 11.0 0.0 1.6 1 0 0 1 1 1 0 EF hand Asp_protease_2 PF13650.1 KOO28073.1 - 0.0026 18.2 0.1 0.27 11.7 0.0 2.7 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.1 KOO28073.1 - 0.029 14.2 0.4 3.7 7.4 0.0 2.6 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Exostosin PF03016.10 KOO28074.1 - 1.3e-22 80.2 0.0 1.7e-22 79.8 0.0 1.1 1 0 0 1 1 1 1 Exostosin family EF-hand_1 PF00036.27 KOO28075.1 - 2.5e-57 185.9 27.3 2.1e-06 26.6 0.2 11.3 12 0 0 12 12 12 10 EF hand EF-hand_6 PF13405.1 KOO28075.1 - 2.6e-57 185.6 29.9 5.1e-06 25.9 0.1 12.1 12 0 0 12 12 12 10 EF-hand domain EF-hand_7 PF13499.1 KOO28075.1 - 3.1e-54 180.9 20.5 1.1e-10 41.5 1.0 6.5 5 2 1 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.1 KOO28075.1 - 4.2e-45 149.1 40.3 8.1e-06 24.9 0.2 11.0 11 0 0 11 11 11 10 EF hand EF-hand_8 PF13833.1 KOO28075.1 - 9.9e-36 121.1 30.7 4.7e-07 29.3 0.0 9.9 6 5 5 11 11 11 10 EF-hand domain pair EF-hand_9 PF14658.1 KOO28075.1 - 1.5e-08 34.3 0.3 0.02 14.7 0.0 5.8 6 1 1 7 7 7 2 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO28075.1 - 7.1e-08 32.4 0.0 2.9 7.9 0.0 5.4 5 0 0 5 5 5 1 Secreted protein acidic and rich in cysteine Ca binding region DinB_2 PF12867.2 KOO28075.1 - 0.002 18.4 0.5 1 9.6 0.0 3.3 3 1 1 4 4 4 1 DinB superfamily Caleosin PF05042.8 KOO28075.1 - 0.014 14.9 0.1 41 3.6 0.0 4.6 4 2 0 4 4 4 0 Caleosin related protein EF-hand_10 PF14788.1 KOO28075.1 - 0.051 13.2 8.1 19 4.9 0.0 6.4 6 2 2 8 8 8 0 EF hand DNA_ligase_OB_2 PF14743.1 KOO28076.1 - 1.3e-26 92.0 0.4 2.1e-26 91.3 0.3 1.3 1 0 0 1 1 1 1 DNA ligase OB-like domain DNA_ligase_A_C PF04679.10 KOO28076.1 - 0.035 14.5 0.4 1.7 9.1 0.0 2.4 1 1 1 2 2 2 0 ATP dependent DNA ligase C terminal region DNA_ligase_A_M PF01068.16 KOO28076.1 - 0.16 11.3 0.0 0.3 10.4 0.0 1.5 1 0 0 1 1 1 0 ATP dependent DNA ligase domain DUF940 PF06082.6 KOO28077.1 - 0.085 11.4 3.8 0.099 11.1 2.7 1.0 1 0 0 1 1 1 0 Bacterial putative lipoprotein (DUF940) Glyco_hydro_2 PF00703.16 KOO28077.1 - 0.62 10.5 2.9 0.35 11.3 0.4 1.7 2 0 0 2 2 2 0 Glycosyl hydrolases family 2 Lin-8 PF03353.10 KOO28077.1 - 2.5 7.2 10.1 3.2 6.9 7.0 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF1217 PF06748.7 KOO28079.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1217) SH3_4 PF06347.8 KOO28081.1 - 0.00039 19.9 0.0 0.00068 19.1 0.0 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_3 PF08239.6 KOO28081.1 - 0.052 13.7 0.0 0.091 12.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial SH3 domain OTCace_N PF02729.16 KOO28082.1 - 6.5e-45 152.2 0.1 3.6e-44 149.8 0.0 1.9 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.19 KOO28082.1 - 3.8e-34 117.8 0.0 7e-34 116.9 0.0 1.5 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain TPR_10 PF13374.1 KOO28083.1 - 2.9e-38 128.6 13.0 2.4e-12 46.3 0.3 5.2 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.1 KOO28083.1 - 6.8e-38 128.4 6.1 1.4e-16 60.1 0.3 3.9 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO28083.1 - 1.7e-13 49.2 5.1 0.0011 18.6 0.0 3.9 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO28083.1 - 1.4e-11 43.4 3.6 0.0052 16.3 0.0 4.0 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO28083.1 - 1.2e-09 37.3 3.0 0.037 13.9 0.0 4.1 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO28083.1 - 2.3e-09 37.6 8.0 0.00019 22.0 2.2 3.0 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28083.1 - 4.3e-09 36.2 8.6 0.062 13.9 0.0 4.1 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_4 PF07721.9 KOO28083.1 - 1.7e-08 34.1 6.8 0.12 12.8 0.4 4.6 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 KOO28083.1 - 2.8e-08 33.2 5.6 7.2e-05 22.3 1.0 2.5 1 1 2 3 3 3 3 TPR repeat TPR_8 PF13181.1 KOO28083.1 - 2.7e-07 29.8 0.5 0.21 11.4 0.0 3.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO28083.1 - 2e-06 27.5 0.1 0.97 9.7 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO28083.1 - 3e-05 24.2 4.5 0.023 15.0 0.4 2.9 1 1 2 3 3 3 3 Tetratricopeptide repeat HisKA_3 PF07730.8 KOO28083.1 - 0.00071 19.8 2.1 5.3 7.4 0.0 3.4 1 1 2 3 3 3 1 Histidine kinase TPR_5 PF12688.2 KOO28083.1 - 0.0025 17.8 3.6 0.32 11.0 0.3 2.6 1 1 1 2 2 2 2 Tetratrico peptide repeat TPR_3 PF07720.7 KOO28083.1 - 0.0079 15.9 0.0 14 5.6 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Hairpins PF04877.7 KOO28083.1 - 0.0079 15.6 0.1 1.2 8.5 0.0 2.8 1 1 0 1 1 1 1 HrpZ Orexin PF02072.10 KOO28083.1 - 0.012 15.4 1.3 0.47 10.2 0.6 2.7 1 1 1 2 2 2 0 Prepro-orexin Osmo_CC PF08946.5 KOO28083.1 - 0.035 14.1 0.0 50 4.0 0.0 3.8 4 0 0 4 4 4 0 Osmosensory transporter coiled coil Rab5-bind PF09311.6 KOO28083.1 - 0.067 13.0 0.0 0.4 10.5 0.0 2.0 1 1 1 3 3 3 0 Rabaptin-like protein Calpain_inhib PF00748.14 KOO28083.1 - 0.24 11.7 1.2 11 6.3 0.0 2.9 2 1 1 3 3 3 0 Calpain inhibitor Ank_2 PF12796.2 KOO28086.1 - 2.9e-17 62.7 0.6 9.1e-09 35.5 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO28086.1 - 3.6e-15 55.6 4.1 1.5e-05 25.0 0.1 3.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO28086.1 - 8e-15 53.8 9.5 5.8e-07 29.0 0.1 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 KOO28086.1 - 4e-14 52.6 2.0 5.8e-06 26.6 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO28086.1 - 2.2e-12 45.9 2.5 0.0015 18.5 0.1 4.3 4 0 0 4 4 4 3 Ankyrin repeat Cytochrom_B561 PF03188.11 KOO28088.1 - 2.4e-15 56.5 14.4 2.4e-15 56.5 10.0 1.8 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 60KD_IMP PF02096.15 KOO28088.1 - 0.00065 19.4 7.5 0.0038 16.8 0.8 2.5 3 0 0 3 3 3 2 60Kd inner membrane protein DUF2427 PF10348.4 KOO28088.1 - 7.7 6.1 19.1 8.7 5.9 6.5 4.1 3 1 1 4 4 4 0 Domain of unknown function (DUF2427) FYVE PF01363.16 KOO28089.1 - 2.5e-18 65.7 10.8 4.8e-18 64.8 7.5 1.5 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.11 KOO28089.1 - 0.0004 20.2 4.6 0.00081 19.2 3.2 1.4 1 0 0 1 1 1 1 FYVE-type zinc finger Prok-RING_2 PF14445.1 KOO28089.1 - 0.76 9.7 4.7 1.9 8.4 3.2 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 2 API5 PF05918.6 KOO28089.1 - 5.4 5.3 4.0 7.5 4.9 2.7 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) RRM_1 PF00076.17 KOO28090.1 - 2.7e-61 203.1 0.0 2.8e-20 71.6 0.0 3.1 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO28090.1 - 3.1e-39 132.7 0.0 1.8e-11 43.8 0.0 3.1 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO28090.1 - 3.4e-20 71.6 0.0 5.1e-07 29.4 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 KOO28090.1 - 7.6e-06 25.7 0.0 0.84 9.5 0.0 3.3 3 0 0 3 3 3 3 RNA binding motif Nup35_RRM_2 PF14605.1 KOO28090.1 - 0.0011 18.7 0.0 2.4 8.0 0.0 2.6 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif Pro_racemase PF05544.6 KOO28090.1 - 0.012 14.4 0.0 0.042 12.6 0.0 1.8 3 0 0 3 3 3 0 Proline racemase DUF3343 PF11823.3 KOO28090.1 - 0.045 13.0 0.0 24 4.2 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3343) VWA_2 PF13519.1 KOO28091.1 - 1.7e-09 38.0 0.1 3.6e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 KOO28091.1 - 0.00087 19.0 0.0 0.0018 18.0 0.0 1.5 1 1 0 1 1 1 1 von Willebrand factor type A domain PAT1 PF09770.4 KOO28091.1 - 1.1 7.3 13.8 1.4 7.0 9.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Peptidase_S8 PF00082.17 KOO28092.1 - 5.6e-25 88.0 1.0 9.8e-25 87.2 0.7 1.4 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.15 KOO28092.1 - 2e-09 37.0 0.1 1.6e-07 30.9 0.0 3.0 3 0 0 3 3 3 1 Proprotein convertase P-domain PDZ_2 PF13180.1 KOO28092.1 - 0.024 14.5 0.1 0.06 13.2 0.0 1.7 2 0 0 2 2 2 0 PDZ domain Phospholip_B PF04916.8 KOO28093.1 - 1.1e-89 301.0 0.0 4.4e-77 259.4 0.0 2.2 2 1 0 2 2 2 2 Phospholipase B DUF3456 PF11938.3 KOO28094.1 - 0.00024 21.1 0.2 0.027 14.4 0.0 2.1 1 1 1 2 2 2 2 TLR4 regulator and MIR-interacting MSAP Alpha_kinase PF02816.13 KOO28095.1 - 5.1e-30 104.5 0.0 6.8e-30 104.1 0.0 1.2 1 0 0 1 1 1 1 Alpha-kinase family zf-CCHC PF00098.18 KOO28096.1 - 0.037 13.9 0.1 0.061 13.2 0.1 1.4 1 0 0 1 1 1 0 Zinc knuckle Flavodoxin_1 PF00258.20 KOO28098.1 - 3e-07 30.5 0.0 4.7e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin SET PF00856.23 KOO28099.1 - 5.8e-08 33.2 0.0 3.8e-06 27.2 0.0 2.5 2 1 0 2 2 2 1 SET domain PARP PF00644.15 KOO28100.1 - 7.8e-19 67.9 0.0 1.4e-18 67.1 0.0 1.4 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain UBA PF00627.26 KOO28100.1 - 2.8e-08 33.3 0.1 4.8e-08 32.6 0.1 1.4 1 0 0 1 1 1 1 UBA/TS-N domain UBA_4 PF14555.1 KOO28100.1 - 0.0014 18.1 0.2 0.0024 17.3 0.2 1.4 1 0 0 1 1 1 1 UBA-like domain CUE PF02845.11 KOO28100.1 - 0.0021 17.4 0.1 0.0037 16.7 0.1 1.4 1 0 0 1 1 1 1 CUE domain NYN_YacP PF05991.6 KOO28101.1 - 0.0019 17.9 0.5 0.011 15.4 0.0 2.1 2 0 0 2 2 2 1 YacP-like NYN domain Thioredoxin PF00085.15 KOO28102.1 - 1.5e-26 92.0 0.1 2.4e-26 91.4 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin UBA PF00627.26 KOO28102.1 - 9e-08 31.7 0.9 2e-07 30.6 0.6 1.6 1 0 0 1 1 1 1 UBA/TS-N domain Thioredoxin_7 PF13899.1 KOO28102.1 - 4.9e-06 26.4 0.1 1.3e-05 25.1 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_8 PF13905.1 KOO28102.1 - 5.7e-06 26.3 0.0 9.3e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.1 KOO28102.1 - 3.7e-05 23.3 0.0 5.2e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 KOO28102.1 - 0.00024 21.2 0.2 0.0011 19.1 0.1 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Redoxin PF08534.5 KOO28102.1 - 0.0034 16.9 0.3 0.36 10.3 0.1 2.3 1 1 1 2 2 2 2 Redoxin CUE PF02845.11 KOO28102.1 - 0.017 14.5 0.1 0.032 13.7 0.1 1.5 1 0 0 1 1 1 0 CUE domain AhpC-TSA PF00578.16 KOO28102.1 - 0.018 14.7 0.2 0.051 13.2 0.2 1.7 1 1 0 1 1 1 0 AhpC/TSA family Lipase_3 PF01764.20 KOO28102.1 - 0.026 14.1 0.1 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Glutaredoxin PF00462.19 KOO28102.1 - 0.032 14.2 0.0 0.075 13.0 0.0 1.6 1 0 0 1 1 1 0 Glutaredoxin UBA_4 PF14555.1 KOO28102.1 - 0.052 13.0 1.6 0.064 12.8 0.3 1.8 2 0 0 2 2 2 0 UBA-like domain CoatB PF10389.4 KOO28102.1 - 0.26 11.1 2.0 15 5.5 0.4 2.5 1 1 1 2 2 2 0 Bacteriophage coat protein B Lipase_3 PF01764.20 KOO28103.1 - 2.8e-20 72.3 0.0 5e-20 71.5 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) FYVE PF01363.16 KOO28103.1 - 4e-06 26.6 4.6 8.7e-06 25.5 3.2 1.6 1 0 0 1 1 1 1 FYVE zinc finger Abhydrolase_5 PF12695.2 KOO28103.1 - 0.00042 20.0 1.1 0.0019 17.9 0.1 2.7 3 1 0 3 3 3 1 Alpha/beta hydrolase family Lar_restr_allev PF14354.1 KOO28103.1 - 0.49 10.7 9.0 1.7 9.0 2.9 2.7 2 0 0 2 2 2 0 Restriction alleviation protein Lar HTH_32 PF13565.1 KOO28104.1 - 0.13 13.0 1.3 2.4 8.9 0.8 2.5 1 1 1 2 2 2 0 Homeodomain-like domain DnaB_bind PF10410.4 KOO28105.1 - 0.17 11.8 1.6 1.7 8.6 0.1 2.9 3 0 0 3 3 3 0 DnaB-helicase binding domain of primase Pkinase PF00069.20 KOO28106.1 - 9.2e-19 67.5 0.0 1.7e-18 66.6 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain PP2C PF00481.16 KOO28106.1 - 6.6e-12 45.3 0.0 8.1e-11 41.7 0.0 2.1 1 1 1 2 2 2 1 Protein phosphatase 2C Pkinase_Tyr PF07714.12 KOO28106.1 - 7.5e-05 21.9 0.0 0.00049 19.2 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 KOO28106.1 - 0.00036 20.3 0.2 0.00094 18.9 0.1 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family PDZ PF00595.19 KOO28106.1 - 0.011 15.9 0.0 0.022 14.9 0.0 1.4 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) Kdo PF06293.9 KOO28106.1 - 0.2 10.6 0.0 0.36 9.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 KOO28106.1 - 0.3 10.4 0.0 0.48 9.7 0.0 1.2 1 0 0 1 1 1 0 RIO1 family ArfGap PF01412.13 KOO28107.1 - 2e-26 92.0 0.9 2.3e-26 91.8 0.6 1.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf GRDA PF04723.9 KOO28107.1 - 0.028 14.1 0.1 0.036 13.7 0.0 1.2 1 0 0 1 1 1 0 Glycine reductase complex selenoprotein A UPF0075 PF03702.9 KOO28107.1 - 0.099 11.5 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0075) DnaJ_CXXCXGXG PF00684.14 KOO28107.1 - 0.26 11.3 5.3 2.5 8.1 2.1 2.8 2 1 1 3 3 3 0 DnaJ central domain EF-hand_1 PF00036.27 KOO28110.1 - 0.002 17.3 0.0 0.0047 16.1 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.1 KOO28110.1 - 0.0032 16.7 0.4 0.009 15.3 0.3 1.8 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 KOO28110.1 - 0.0043 16.6 0.1 0.0093 15.5 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO28110.1 - 0.017 14.9 0.1 0.11 12.4 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain EF-hand_7 PF13499.1 KOO28110.1 - 0.017 15.2 0.0 0.072 13.2 0.0 2.1 1 0 0 1 1 1 0 EF-hand domain pair TPR_MLP1_2 PF07926.7 KOO28110.1 - 0.019 14.7 0.9 0.04 13.6 0.6 1.5 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DivIC PF04977.10 KOO28110.1 - 0.02 14.3 3.4 0.024 14.0 0.7 2.4 2 0 0 2 2 2 0 Septum formation initiator Atg14 PF10186.4 KOO28110.1 - 0.26 10.1 1.5 0.48 9.3 1.0 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Spc7 PF08317.6 KOO28110.1 - 0.32 9.5 0.1 0.5 8.9 0.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein adh_short PF00106.20 KOO28111.1 - 1.4e-13 51.0 1.7 6.5e-13 48.9 1.1 2.2 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOO28111.1 - 6.9e-08 32.3 1.3 8.7e-07 28.7 0.3 2.4 1 1 1 2 2 2 1 KR domain adh_short_C2 PF13561.1 KOO28111.1 - 0.0011 18.7 0.0 0.0048 16.6 0.0 1.9 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 KOO28111.1 - 0.019 14.9 1.6 0.037 14.0 0.3 2.1 2 0 0 2 2 2 0 NADH(P)-binding Epimerase PF01370.16 KOO28111.1 - 0.02 14.3 0.1 0.045 13.1 0.0 1.6 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family DAGAT PF03982.8 KOO28112.1 - 2.1e-40 138.2 0.0 2.7e-40 137.9 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol acyltransferase TPR_1 PF00515.23 KOO28113.1 - 8.7e-33 110.5 4.6 3.1e-06 26.5 0.0 8.8 10 0 0 10 10 8 7 Tetratricopeptide repeat TPR_2 PF07719.12 KOO28113.1 - 1.9e-29 99.1 19.3 1.2e-05 24.8 0.0 10.1 12 0 0 12 12 10 6 Tetratricopeptide repeat TPR_11 PF13414.1 KOO28113.1 - 5.1e-28 96.5 14.5 1.1e-10 40.9 0.1 6.7 4 1 0 6 6 6 4 TPR repeat TPR_8 PF13181.1 KOO28113.1 - 2.3e-23 80.1 0.0 9.6e-05 21.9 0.0 8.9 10 0 0 10 10 10 4 Tetratricopeptide repeat Apc3 PF12895.2 KOO28113.1 - 1.8e-20 72.8 19.1 2e-14 53.4 2.2 5.8 6 0 0 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 KOO28113.1 - 5e-20 71.2 9.7 6.7e-09 35.5 0.1 6.8 4 1 3 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.1 KOO28113.1 - 9.5e-20 70.7 17.7 5.4e-07 30.1 0.0 7.2 5 2 3 8 8 7 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28113.1 - 6.5e-19 66.7 20.1 0.0039 17.7 0.0 11.0 7 3 4 11 11 10 4 Tetratricopeptide repeat TPR_7 PF13176.1 KOO28113.1 - 1.4e-16 58.8 8.4 0.0007 19.2 0.0 7.2 7 1 0 7 7 6 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO28113.1 - 8.7e-15 53.6 0.0 0.0073 16.4 0.0 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO28113.1 - 8.4e-12 45.2 10.2 0.097 13.0 0.0 7.1 7 1 1 8 8 7 5 Tetratricopeptide repeat TPR_3 PF07720.7 KOO28113.1 - 6.1e-10 38.6 0.3 0.002 17.8 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.1 KOO28113.1 - 1.8e-07 30.8 12.3 0.24 11.3 0.0 6.7 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOO28113.1 - 2.2e-07 30.8 8.3 1.3 9.5 0.0 8.2 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO28113.1 - 0.00011 21.9 12.0 0.13 12.1 0.1 5.5 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_15 PF13429.1 KOO28113.1 - 0.00036 19.7 5.7 0.11 11.4 0.1 4.4 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_4 PF07721.9 KOO28113.1 - 0.001 19.2 3.4 13 6.6 0.0 5.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.7 KOO28113.1 - 0.003 18.1 0.9 2.9 8.6 0.0 3.9 2 0 0 2 2 2 1 Sel1 repeat Fis1_TPR_C PF14853.1 KOO28113.1 - 0.014 15.2 1.3 0.85 9.5 0.0 3.6 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat RPN7 PF10602.4 KOO28113.1 - 0.55 9.5 4.9 4.5 6.6 0.0 3.9 3 2 2 5 5 5 0 26S proteasome subunit RPN7 Glyco_hydro_67N PF03648.9 KOO28114.1 - 0.00085 19.3 0.0 0.0021 18.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 N-terminus TPR_11 PF13414.1 KOO28115.1 - 1.6e-16 59.6 11.4 1.6e-10 40.5 1.0 3.8 2 1 1 3 3 3 3 TPR repeat TPR_1 PF00515.23 KOO28115.1 - 3.9e-07 29.3 9.3 4.7e-05 22.8 0.0 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO28115.1 - 6.5e-07 28.7 15.1 0.0004 20.0 0.0 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOO28115.1 - 6.6e-06 26.3 7.5 0.00011 22.4 1.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO28115.1 - 1.7e-05 25.3 6.1 1.7e-05 25.3 4.2 5.5 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28115.1 - 0.0008 19.8 2.1 0.0008 19.8 1.5 5.1 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO28115.1 - 0.00089 19.2 0.2 13 6.3 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOO28115.1 - 0.015 15.1 1.6 0.015 15.1 1.1 3.7 3 2 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO28115.1 - 0.04 13.7 6.8 0.074 12.8 0.1 3.8 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOO28115.1 - 0.13 12.1 3.5 2.2 8.2 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO28115.1 - 3.3 7.6 9.0 0.21 11.4 0.4 3.0 2 2 1 3 3 3 0 Tetratricopeptide repeat Transformer PF06495.6 KOO28117.1 - 0.036 13.9 1.1 0.039 13.8 0.7 1.1 1 0 0 1 1 1 0 Fruit fly transformer protein Humanin PF15040.1 KOO28117.1 - 0.04 13.1 0.5 0.076 12.2 0.3 1.5 1 0 0 1 1 1 0 Humanin family CSD PF00313.17 KOO28118.1 - 7.5e-22 76.8 0.0 9.5e-22 76.5 0.0 1.1 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.6 KOO28118.1 - 0.00041 19.8 0.1 0.00096 18.6 0.1 1.5 1 0 0 1 1 1 1 Ribonuclease B OB domain OGFr_III PF04680.8 KOO28118.1 - 0.2 11.8 1.2 0.67 10.1 0.9 1.9 1 0 0 1 1 1 0 Opioid growth factor receptor repeat Aldose_epim PF01263.15 KOO28119.1 - 6.2e-43 147.0 0.0 7e-43 146.8 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase MutS_I PF01624.15 KOO28120.1 - 1.8e-20 73.0 0.0 3.7e-20 72.0 0.0 1.5 1 0 0 1 1 1 1 MutS domain I Ion_trans PF00520.26 KOO28120.1 - 2.9e-16 59.3 0.7 4e-16 58.8 0.5 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO28120.1 - 7.8e-14 51.1 6.7 2.1e-13 49.7 4.6 1.8 1 1 0 1 1 1 1 Ion channel DUF4339 PF14237.1 KOO28121.1 - 0.0002 20.8 0.0 0.00039 19.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4339) GYF PF02213.11 KOO28121.1 - 0.012 15.2 0.0 0.02 14.4 0.0 1.4 1 0 0 1 1 1 0 GYF domain Methyltransf_18 PF12847.2 KOO28122.1 - 3.2e-10 40.5 0.1 3.7e-10 40.3 0.1 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO28122.1 - 1.4e-07 31.8 0.0 1.9e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO28122.1 - 5.1e-07 29.3 0.0 5.9e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO28122.1 - 2.7e-06 27.7 0.0 3.4e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO28122.1 - 3.7e-06 26.2 0.0 4.1e-06 26.0 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 KOO28122.1 - 7.4e-05 22.7 0.6 9.4e-05 22.4 0.4 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO28122.1 - 0.00029 21.1 0.0 0.00035 20.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO28122.1 - 0.0014 18.3 0.0 0.0019 17.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain DDE_3 PF13358.1 KOO28125.1 - 0.052 13.2 0.0 0.071 12.8 0.0 1.5 1 1 0 1 1 1 0 DDE superfamily endonuclease Flavokinase PF01687.12 KOO28126.1 - 1.8e-33 115.0 0.0 3e-33 114.3 0.0 1.3 1 0 0 1 1 1 1 Riboflavin kinase Dpy-30 PF05186.8 KOO28126.1 - 0.011 15.2 0.0 0.017 14.6 0.0 1.3 1 0 0 1 1 1 0 Dpy-30 motif DS PF01916.12 KOO28127.1 - 1e-126 422.0 0.0 1.2e-126 421.8 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase DUF751 PF05421.6 KOO28128.1 - 7.9e-13 48.4 3.0 1.6e-12 47.5 2.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF751) DUF4131 PF13567.1 KOO28128.1 - 0.0063 15.9 0.1 0.012 15.0 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) V4R PF02830.13 KOO28128.1 - 0.043 13.6 0.3 0.12 12.1 0.0 1.8 2 0 0 2 2 2 0 V4R domain Kinesin PF00225.18 KOO28131.1 - 3.4e-55 187.0 0.0 4.8e-55 186.5 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Ank_2 PF12796.2 KOO28131.1 - 2.4e-31 107.9 0.1 5.7e-17 61.8 0.0 2.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO28131.1 - 2.4e-16 58.5 0.0 2.1e-07 30.4 0.0 3.3 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 KOO28131.1 - 4e-15 55.8 0.0 1.7e-06 28.3 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO28131.1 - 1.5e-11 44.1 0.0 7.3e-07 29.2 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO28131.1 - 6.6e-08 32.0 0.0 0.0072 16.4 0.0 3.3 2 0 0 2 2 2 2 Ankyrin repeat 2OG-FeII_Oxy_5 PF13759.1 KOO28131.1 - 1.4e-06 28.5 0.3 3.9e-06 27.0 0.1 1.9 2 0 0 2 2 2 1 Putative 2OG-Fe(II) oxygenase EF-hand_7 PF13499.1 KOO28131.1 - 2.5e-05 24.3 0.3 0.0041 17.2 0.2 2.0 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO28131.1 - 0.0033 16.7 0.1 0.0033 16.7 0.0 3.1 4 0 0 4 4 4 1 EF hand EF-hand_1 PF00036.27 KOO28131.1 - 0.0037 16.4 1.0 0.042 13.1 0.0 3.0 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.1 KOO28131.1 - 0.01 15.6 2.2 0.22 11.5 0.0 3.3 3 0 0 3 3 3 0 EF-hand domain Bac_DnaA PF00308.13 KOO28131.1 - 0.25 10.9 0.0 0.59 9.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein DnaG_DnaB_bind PF08278.6 KOO28133.1 - 4.7e-06 26.8 11.1 0.00039 20.6 1.8 2.6 2 1 1 3 3 3 2 DNA primase DnaG DnaB-binding Caldesmon PF02029.10 KOO28133.1 - 0.0031 15.9 15.8 0.0043 15.5 10.9 1.1 1 0 0 1 1 1 1 Caldesmon DUF572 PF04502.8 KOO28133.1 - 0.012 14.8 15.0 0.014 14.5 10.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF896 PF05979.7 KOO28133.1 - 0.25 10.9 5.6 0.26 10.9 0.3 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF896) CCDC-167 PF15188.1 KOO28133.1 - 0.36 10.8 15.1 0.71 9.8 2.2 2.8 1 1 2 3 3 3 0 Coiled-coil domain-containing protein 167 GvpG PF05120.7 KOO28133.1 - 0.36 10.6 6.3 0.45 10.3 0.7 2.8 2 1 1 3 3 3 0 Gas vesicle protein G zf-HC2 PF13490.1 KOO28133.1 - 0.54 10.2 6.0 7.2 6.6 0.1 3.4 2 1 1 3 3 3 0 Putative zinc-finger Sigma70_ner PF04546.8 KOO28133.1 - 0.66 9.5 11.0 0.84 9.2 7.7 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF1311 PF07007.7 KOO28133.1 - 0.69 10.0 9.3 0.51 10.4 5.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1311) Caudo_TAP PF02413.12 KOO28133.1 - 8.3 6.5 17.9 1.5e+03 -0.8 12.4 2.8 1 1 0 1 1 1 0 Caudovirales tail fibre assembly protein Aldo_ket_red PF00248.16 KOO28134.1 - 3.9e-27 94.7 0.0 6.4e-27 94.0 0.0 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family Glyco_transf_8 PF01501.15 KOO28134.1 - 1.6e-10 40.7 0.0 2.4e-09 36.8 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 8 PARP PF00644.15 KOO28135.1 - 2.4e-13 50.0 0.1 9.5e-13 48.0 0.0 2.1 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain 3HCDH_N PF02737.13 KOO28135.1 - 0.0036 16.9 3.9 0.0077 15.8 0.0 2.8 2 1 1 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain LMBR1 PF04791.11 KOO28135.1 - 0.64 8.5 7.8 0.23 10.0 1.7 2.0 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF4586 PF15239.1 KOO28136.1 - 1.5e-07 31.2 0.9 1.8e-07 30.9 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) Nucleotid_trans PF03407.11 KOO28137.1 - 0.014 15.2 0.0 0.02 14.6 0.0 1.2 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Radial_spoke PF04712.7 KOO28139.1 - 1.6e-12 46.9 0.2 0.00062 18.6 0.0 3.1 2 1 1 3 3 3 3 Radial spokehead-like protein CoA_transf_3 PF02515.12 KOO28141.1 - 3.3e-33 114.5 1.7 4.2e-25 88.1 0.1 2.2 2 0 0 2 2 2 2 CoA-transferase family III Anoctamin PF04547.7 KOO28142.1 - 1.5e-98 330.4 0.0 2.4e-98 329.7 0.0 1.4 1 0 0 1 1 1 1 Calcium-activated chloride channel DUF2360 PF10152.4 KOO28142.1 - 0.35 11.1 9.7 0.91 9.7 6.7 1.7 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) PsbP PF01789.11 KOO28143.1 - 7.3e-06 25.5 0.0 1.8e-05 24.2 0.0 1.6 1 1 0 1 1 1 1 PsbP zf-RING_2 PF13639.1 KOO28144.1 - 0.0002 21.0 13.7 0.0002 21.0 9.5 2.2 2 0 0 2 2 2 1 Ring finger domain C1_1 PF00130.17 KOO28144.1 - 0.018 14.7 11.4 0.054 13.2 7.9 1.8 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HWE_HK PF07536.9 KOO28144.1 - 0.079 13.4 0.7 5.4 7.5 0.0 2.5 2 0 0 2 2 2 0 HWE histidine kinase zinc_ribbon_2 PF13240.1 KOO28144.1 - 1.7 8.2 6.8 1.8 8.1 0.6 2.6 2 0 0 2 2 2 0 zinc-ribbon domain zf-C3HC4_2 PF13923.1 KOO28144.1 - 3.4 7.7 17.7 1.4 8.9 9.4 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Laminin_G_3 PF13385.1 KOO28145.1 - 8.6e-11 42.3 0.0 9.5e-11 42.1 0.0 1.0 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Pentaxin PF00354.12 KOO28145.1 - 0.093 12.1 0.0 0.11 11.8 0.0 1.4 1 1 0 1 1 1 0 Pentaxin family NAD_binding_8 PF13450.1 KOO28146.1 - 1e-15 57.4 0.4 2.3e-15 56.3 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOO28146.1 - 6.4e-10 38.4 0.3 1e-08 34.4 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Amino_oxidase PF01593.19 KOO28146.1 - 3.7e-08 32.8 0.0 6.6e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.19 KOO28146.1 - 2.3e-06 26.7 0.1 4e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.12 KOO28146.1 - 2.7e-06 26.6 0.5 4.4e-06 25.9 0.3 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.9 KOO28146.1 - 8.8e-06 25.7 0.2 1.4e-05 25.0 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 KOO28146.1 - 9.9e-06 24.8 0.5 1.4e-05 24.3 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.22 KOO28146.1 - 2.8e-05 24.4 0.4 6.1e-05 23.3 0.3 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 KOO28146.1 - 0.00022 20.4 1.8 0.00032 19.9 1.3 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 KOO28146.1 - 0.0019 16.7 0.1 0.0063 15.0 0.4 1.6 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.1 KOO28146.1 - 0.0021 18.1 0.1 0.0037 17.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 KOO28146.1 - 0.0032 16.4 1.2 0.0046 15.8 0.8 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A 3HCDH_N PF02737.13 KOO28146.1 - 0.02 14.5 0.6 0.032 13.8 0.4 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Trp_halogenase PF04820.9 KOO28146.1 - 0.099 11.2 0.7 0.14 10.7 0.5 1.2 1 0 0 1 1 1 0 Tryptophan halogenase EF-hand_6 PF13405.1 KOO28148.1 - 0.014 15.2 0.1 0.032 14.1 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain COX16 PF14138.1 KOO28148.1 - 0.019 15.1 0.3 0.05 13.7 0.2 1.7 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 EF-hand_7 PF13499.1 KOO28148.1 - 0.022 14.8 0.2 0.068 13.3 0.1 1.6 1 1 1 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.27 KOO28148.1 - 0.088 12.1 0.3 0.19 11.1 0.2 1.6 1 0 0 1 1 1 0 EF hand VSG_B PF13206.1 KOO28148.1 - 0.37 9.8 6.4 0.4 9.7 3.9 1.3 1 1 0 1 1 1 0 Trypanosomal VSG domain SMC_N PF02463.14 KOO28150.1 - 6.9e-17 61.4 0.0 8.5e-17 61.1 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 KOO28150.1 - 6.1e-11 43.0 0.0 6.3e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.1 KOO28150.1 - 2.9e-06 27.4 0.0 3.5e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 KOO28150.1 - 1e-05 24.9 0.0 2.1e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 KOO28150.1 - 1.2e-05 24.6 0.0 1.2e-05 24.6 0.0 1.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_16 PF13191.1 KOO28150.1 - 0.0014 18.6 0.5 0.002 18.1 0.4 1.5 1 1 0 1 1 1 1 AAA ATPase domain FtsK_SpoIIIE PF01580.13 KOO28150.1 - 0.0028 17.1 0.0 0.0045 16.5 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family MukB PF04310.7 KOO28150.1 - 0.017 14.4 0.0 0.026 13.8 0.0 1.3 1 0 0 1 1 1 0 MukB N-terminal AP2 PF00847.15 KOO28151.1 - 5.8e-11 42.3 14.7 0.00021 21.3 0.0 6.6 7 2 0 7 7 7 4 AP2 domain IF3_N PF05198.11 KOO28151.1 - 0.0024 17.7 4.3 4.8 7.1 0.0 4.1 3 1 0 3 3 3 2 Translation initiation factor IF-3, N-terminal domain CedA PF10729.4 KOO28151.1 - 0.0056 16.1 0.0 24 4.5 0.0 3.3 3 0 0 3 3 3 1 Cell division activator CedA AbrB-like PF14250.1 KOO28151.1 - 0.069 13.0 0.3 13 5.7 0.0 3.3 3 0 0 3 3 3 0 AbrB-like transcriptional regulator DUF2493 PF10686.4 KOO28151.1 - 8.5 6.0 6.8 29 4.3 0.2 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2493) zf-RING_2 PF13639.1 KOO28152.1 - 5.6e-11 42.0 5.9 8.4e-11 41.5 4.1 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KOO28152.1 - 8.8e-06 25.7 3.2 2.5e-05 24.2 2.3 1.5 1 1 0 1 1 1 1 RING-H2 zinc finger FANCL_C PF11793.3 KOO28152.1 - 2.4e-05 24.2 4.3 4.2e-05 23.4 3.0 1.4 1 1 0 1 1 1 1 FANCL C-terminal domain zf-C3HC4_2 PF13923.1 KOO28152.1 - 7.3e-05 22.7 7.8 0.0018 18.2 5.4 2.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO28152.1 - 0.001 18.6 5.9 0.0022 17.6 4.1 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO28152.1 - 0.0012 18.5 6.3 0.0021 17.7 4.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain RINGv PF12906.2 KOO28152.1 - 0.0021 18.0 4.8 0.0048 16.9 3.3 1.7 1 1 0 1 1 1 1 RING-variant domain zf-C3HC4 PF00097.20 KOO28152.1 - 0.028 14.0 5.6 0.23 11.1 3.9 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 KOO28152.1 - 0.05 13.4 5.6 0.47 10.3 3.9 2.1 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger C1_1 PF00130.17 KOO28152.1 - 0.075 12.7 3.1 0.16 11.6 0.9 2.1 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DNMT1-RFD PF12047.3 KOO28154.1 - 5.7e-19 68.2 0.0 1.1e-18 67.3 0.0 1.5 1 0 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain HMG_box PF00505.14 KOO28154.1 - 1e-10 41.7 0.1 4e-10 39.8 0.1 2.1 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO28154.1 - 2.4e-09 37.4 0.1 6.8e-09 35.9 0.0 1.8 1 0 0 1 1 1 1 HMG-box domain ADH_N PF08240.7 KOO28155.1 - 1.9e-14 53.3 3.4 3.2e-14 52.6 2.3 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 KOO28155.1 - 5.9e-06 27.1 0.0 3.7e-05 24.6 0.0 2.3 1 1 1 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 KOO28155.1 - 2.3e-05 23.9 0.1 0.00011 21.7 0.0 2.1 1 1 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_10 PF13460.1 KOO28155.1 - 0.0093 15.9 0.7 0.016 15.2 0.5 1.4 1 0 0 1 1 1 1 NADH(P)-binding Shikimate_DH PF01488.15 KOO28155.1 - 0.085 12.9 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase HEAT_EZ PF13513.1 KOO28158.1 - 0.0024 18.2 5.4 0.023 15.2 0.3 15.3 9 5 6 15 15 15 3 HEAT-like repeat RICTOR_V PF14668.1 KOO28158.1 - 0.0038 17.1 0.1 0.013 15.4 0.1 1.9 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, domain 5 Cnd3 PF12719.2 KOO28158.1 - 0.0085 15.1 0.1 0.18 10.7 0.0 2.8 3 0 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain DUF4042 PF13251.1 KOO28158.1 - 0.0099 15.3 0.1 0.47 9.8 0.0 3.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4042) Vac14_Fab1_bd PF12755.2 KOO28158.1 - 0.13 12.6 0.0 3 8.2 0.0 3.1 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region MMS19_C PF12460.3 KOO28158.1 - 0.15 10.7 0.0 11 4.5 0.0 3.1 4 0 0 4 4 4 0 RNAPII transcription regulator C-terminal cNMP_binding PF00027.24 KOO28159.1 - 9.1e-10 38.2 0.0 1.5e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain cNMP_binding PF00027.24 KOO28160.1 - 4.2e-26 90.5 0.0 3.5e-15 55.5 0.0 2.2 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain WD40 PF00400.27 KOO28163.1 - 1e-51 171.0 16.9 1.4e-12 47.0 0.1 4.2 4 0 0 4 4 4 4 WD domain, G-beta repeat PD40 PF07676.7 KOO28163.1 - 2.3e-11 43.0 1.3 0.39 10.4 0.0 4.4 4 0 0 4 4 4 4 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOO28163.1 - 4.1e-07 29.9 0.1 0.0017 18.0 0.0 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.1 KOO28163.1 - 7.8e-06 25.6 0.1 0.48 10.2 0.0 3.4 1 1 1 3 3 3 2 Ciliary BBSome complex subunit 2, middle region Nbas_N PF15492.1 KOO28163.1 - 3.2e-05 23.1 1.1 0.32 10.0 0.1 3.5 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal DUF3312 PF11768.3 KOO28163.1 - 0.0001 20.6 0.0 0.22 9.7 0.0 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF3312) Dfp1_Him1_M PF08630.5 KOO28163.1 - 0.0013 18.4 4.9 8 6.2 0.0 4.0 4 0 0 4 4 4 1 Dfp1/Him1, central region DUF1513 PF07433.6 KOO28163.1 - 0.0014 17.6 0.0 2.9 6.7 0.0 3.3 1 1 1 3 3 3 1 Protein of unknown function (DUF1513) Nucleoporin_N PF08801.6 KOO28163.1 - 0.0037 16.0 4.9 1.1 7.9 0.2 3.4 1 1 1 3 3 3 1 Nup133 N terminal like TFIIIC_delta PF12657.2 KOO28163.1 - 0.0055 16.4 0.3 0.1 12.3 0.0 2.5 1 1 2 3 3 3 2 Transcription factor IIIC subunit delta N-term Gmad1 PF10647.4 KOO28163.1 - 0.01 15.2 0.2 52 3.1 0.0 3.8 2 2 1 4 4 4 0 Lipoprotein LpqB beta-propeller domain SLH PF00395.15 KOO28163.1 - 0.028 14.1 1.0 63 3.4 0.0 4.1 4 0 0 4 4 4 0 S-layer homology domain MMS1_N PF10433.4 KOO28163.1 - 0.039 12.0 0.1 2.5 6.1 0.0 2.6 1 1 2 3 3 3 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term DUF3935 PF13071.1 KOO28163.1 - 0.053 13.9 0.2 25 5.3 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3935) Flt3_lig PF02947.9 KOO28163.1 - 0.059 13.2 0.0 19 5.1 0.0 3.3 2 1 1 3 3 3 0 flt3 ligand rOmpB PF12334.3 KOO28163.1 - 0.1 11.9 1.2 21 4.3 0.0 3.4 1 1 1 3 3 3 0 Rickettsia outer membrane protein B UN_NPL4 PF11543.3 KOO28163.1 - 0.13 12.5 0.8 1.1e+02 3.1 0.0 3.9 4 0 0 4 4 4 0 Nuclear pore localisation protein NPL4 Proteasome_A_N PF10584.4 KOO28163.1 - 0.73 9.2 5.6 1.1e+02 2.2 0.0 4.1 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature UAA PF08449.6 KOO28164.1 - 2.1e-06 26.9 3.5 2.1e-06 26.9 2.4 2.2 2 0 0 2 2 2 1 UAA transporter family EamA PF00892.15 KOO28164.1 - 0.00026 21.0 25.0 0.0017 18.3 6.5 2.9 3 0 0 3 3 3 2 EamA-like transporter family EmrE PF13536.1 KOO28164.1 - 0.0089 16.2 2.6 0.0089 16.2 1.8 3.7 2 1 2 4 4 4 1 Multidrug resistance efflux transporter TPT PF03151.11 KOO28164.1 - 5.6 6.5 18.4 0.021 14.4 3.3 2.8 2 1 0 2 2 2 0 Triose-phosphate Transporter family tRNA-synt_1e PF01406.14 KOO28165.1 - 9.4e-112 373.0 0.0 2e-111 371.9 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.6 KOO28165.1 - 2.5e-07 29.7 0.3 2e-05 23.4 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 KOO28165.1 - 0.00081 17.5 0.0 0.0028 15.7 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1f PF01921.13 KOO28165.1 - 0.17 10.5 0.1 2.6 6.6 0.0 2.0 2 0 0 2 2 2 0 tRNA synthetases class I (K) ROK PF00480.15 KOO28166.1 - 1.4e-21 77.1 0.0 2.1e-21 76.5 0.0 1.3 1 0 0 1 1 1 1 ROK family Glucokinase PF02685.11 KOO28166.1 - 0.022 13.5 0.1 0.022 13.5 0.1 2.6 3 0 0 3 3 3 0 Glucokinase PRK PF00485.13 KOO28167.1 - 1e-47 162.1 0.0 1.3e-47 161.9 0.0 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.1 KOO28167.1 - 5.8e-07 29.8 0.0 1.2e-06 28.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO28167.1 - 3.8e-05 24.4 0.1 0.00014 22.7 0.1 1.8 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOO28167.1 - 0.0001 21.4 0.0 0.00016 20.8 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin CoaE PF01121.15 KOO28167.1 - 0.00018 20.9 0.0 0.084 12.2 0.0 2.3 2 0 0 2 2 2 2 Dephospho-CoA kinase AAA_33 PF13671.1 KOO28167.1 - 0.011 15.5 0.0 0.032 14.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 KOO28167.1 - 0.037 14.0 0.0 0.051 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Spore_II_R PF09551.5 KOO28167.1 - 0.046 13.7 0.0 0.089 12.8 0.0 1.4 1 0 0 1 1 1 0 Stage II sporulation protein R (spore_II_R) T2SE PF00437.15 KOO28167.1 - 0.1 11.4 0.0 0.17 10.7 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein CPT PF07931.7 KOO28167.1 - 0.11 12.0 0.1 0.35 10.4 0.0 1.8 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein MobB PF03205.9 KOO28167.1 - 0.11 12.1 0.0 0.3 10.7 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B BACK PF07707.10 KOO28168.1 - 1e-15 57.4 0.0 9.6e-15 54.2 0.0 2.3 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 KOO28168.1 - 5e-13 49.0 0.0 1.3e-12 47.7 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain MATH PF00917.21 KOO28168.1 - 9.1e-12 45.2 0.0 1.7e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 MATH domain WD40 PF00400.27 KOO28170.1 - 4.5e-10 39.0 2.9 7.9e-08 31.8 0.0 4.2 4 0 0 4 4 4 1 WD domain, G-beta repeat DUF1513 PF07433.6 KOO28170.1 - 0.00084 18.3 0.1 0.0014 17.6 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1513) Nup160 PF11715.3 KOO28170.1 - 0.0058 14.8 0.0 0.0082 14.3 0.0 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 EamA PF00892.15 KOO28171.1 - 2.1e-12 47.1 18.8 2.3e-09 37.3 4.6 2.3 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.11 KOO28171.1 - 3.4e-10 39.7 10.4 1.4e-09 37.7 0.7 2.4 2 1 0 2 2 2 2 Triose-phosphate Transporter family Nuc_sug_transp PF04142.10 KOO28171.1 - 0.0069 15.5 0.4 0.011 14.8 0.0 1.6 2 0 0 2 2 2 1 Nucleotide-sugar transporter EmrE PF13536.1 KOO28171.1 - 0.0094 16.1 5.3 0.0094 16.1 3.7 2.8 3 0 0 3 3 3 1 Multidrug resistance efflux transporter NAD_binding_6 PF08030.7 KOO28172.1 - 4.4e-17 62.4 0.0 4.3e-16 59.1 0.0 2.4 2 1 0 2 2 2 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 KOO28172.1 - 2e-10 40.8 5.8 2e-10 40.8 4.0 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 KOO28172.1 - 3e-07 30.2 0.0 5.3e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain WW PF00397.21 KOO28172.1 - 6.6e-07 29.0 4.5 6.6e-07 29.0 3.1 2.5 2 0 0 2 2 2 1 WW domain NAD_binding_1 PF00175.16 KOO28172.1 - 1.6 9.3 3.3 4.3 7.9 0.0 3.0 3 1 0 3 3 3 0 Oxidoreductase NAD-binding domain Zip PF02535.17 KOO28173.1 - 6e-18 64.9 13.9 1.3e-11 44.1 2.9 3.3 2 1 2 4 4 4 2 ZIP Zinc transporter Cation_efflux PF01545.16 KOO28173.1 - 0.033 13.2 3.3 0.059 12.4 0.2 2.4 1 1 0 2 2 2 0 Cation efflux family Pox_A14 PF05767.7 KOO28173.1 - 0.09 12.7 0.7 18 5.3 0.0 3.4 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 DUF4199 PF13858.1 KOO28173.1 - 3.1 7.7 8.5 1.2 9.0 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4199) KH_1 PF00013.24 KOO28174.1 - 3.7e-85 279.4 24.3 5.9e-14 51.4 0.3 10.8 11 0 0 11 11 11 9 KH domain KH_3 PF13014.1 KOO28174.1 - 6.4e-46 153.3 23.2 1.1e-08 34.5 0.6 9.3 10 0 0 10 10 10 8 KH domain KH_2 PF07650.12 KOO28174.1 - 3e-17 61.9 35.0 0.0026 17.2 0.5 8.2 6 2 1 8 8 8 7 KH domain SLS PF14611.1 KOO28174.1 - 1.8e-16 60.2 4.8 5.1e-06 26.0 0.0 5.3 2 2 2 5 5 5 3 Mitochondrial inner-membrane-bound regulator KH_4 PF13083.1 KOO28174.1 - 2.5e-07 30.2 20.2 0.0092 15.6 0.1 6.1 6 0 0 6 6 6 3 KH domain KH_5 PF13184.1 KOO28174.1 - 0.016 15.0 10.4 24 4.7 0.0 6.4 6 0 0 6 6 6 0 NusA-like KH domain Secretin_N PF03958.12 KOO28174.1 - 0.21 11.8 15.3 2.5 8.3 0.1 6.4 5 2 2 7 7 7 0 Bacterial type II/III secretion system short domain BMC PF00936.14 KOO28174.1 - 0.25 11.0 0.0 0.25 11.0 0.0 7.5 10 0 0 10 10 10 0 BMC domain AAA_13 PF13166.1 KOO28174.1 - 1.6 7.1 9.0 2.9 6.2 6.2 1.4 1 0 0 1 1 1 0 AAA domain SNARE_assoc PF09335.6 KOO28175.1 - 3.4e-16 59.5 0.3 3.4e-16 59.5 0.2 1.9 2 0 0 2 2 2 1 SNARE associated Golgi protein ThiW PF09512.5 KOO28175.1 - 0.053 13.3 1.0 0.39 10.5 0.2 2.2 2 0 0 2 2 2 0 Thiamine-precursor transporter protein (ThiW) RCC1 PF00415.13 KOO28176.1 - 8.7e-70 230.7 21.6 2.8e-14 53.0 0.1 8.5 7 1 1 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO28176.1 - 7.1e-35 117.8 37.5 1.3e-06 27.8 0.3 8.5 8 1 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat EF-hand_1 PF00036.27 KOO28177.1 - 3.4e-10 38.4 1.1 2.8e-05 23.0 0.2 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO28177.1 - 4.5e-10 39.5 0.1 6.7e-08 32.5 0.0 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO28177.1 - 3.4e-08 32.7 0.4 0.0025 17.5 0.2 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO28177.1 - 6.7e-08 32.0 0.0 7.7e-06 25.4 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO28177.1 - 2.1e-05 23.6 2.5 0.00011 21.3 0.3 2.4 2 0 0 2 2 2 1 EF hand PG_binding_1 PF01471.13 KOO28177.1 - 0.042 13.8 0.2 0.16 12.0 0.1 1.9 1 1 0 1 1 1 0 Putative peptidoglycan binding domain Pkinase PF00069.20 KOO28178.1 - 2.3e-41 141.6 0.0 3.3e-41 141.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO28178.1 - 1.5e-21 76.6 0.0 2.6e-21 75.8 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO28178.1 - 1.1e-06 27.8 0.0 2.2e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO28178.1 - 0.037 13.7 2.8 0.05 13.3 0.0 2.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.9 KOO28178.1 - 0.069 12.1 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family NUDIX PF00293.23 KOO28179.1 - 1.6e-17 63.4 0.0 2.4e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain PWWP PF00855.12 KOO28180.1 - 2.6e-14 53.1 0.3 2.6e-14 53.1 0.2 1.9 2 0 0 2 2 2 1 PWWP domain HMG_box PF00505.14 KOO28180.1 - 3.3e-09 36.8 9.4 8.8e-08 32.3 0.0 3.4 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO28180.1 - 1.1e-05 25.6 5.7 0.0034 17.7 0.1 3.3 2 1 1 3 3 3 2 HMG-box domain CHDNT PF08073.7 KOO28180.1 - 0.0012 18.5 0.0 0.0034 17.0 0.0 1.7 2 0 0 2 2 2 1 CHDNT (NUC034) domain FKBP_N PF01346.13 KOO28180.1 - 0.28 11.2 7.4 1.1 9.3 1.7 3.0 2 1 1 3 3 3 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Band_7 PF01145.20 KOO28181.1 - 1.7e-18 67.1 4.7 2.3e-18 66.7 3.2 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family DUF2733 PF10813.3 KOO28181.1 - 0.0047 16.4 0.1 0.011 15.3 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2733) Band_7_1 PF13421.1 KOO28181.1 - 0.01 15.3 0.5 0.015 14.8 0.4 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family Chorein_N PF12624.2 KOO28183.1 - 5.7e-35 119.4 0.0 5.6e-34 116.2 0.0 2.3 2 0 0 2 2 2 1 N-terminal region of Chorein, a TM vesicle-mediated sorter DUF1162 PF06650.7 KOO28183.1 - 2.5e-22 79.4 0.0 1.8e-17 63.4 0.0 3.5 4 0 0 4 4 4 3 Protein of unknown function (DUF1162) Apt1 PF10351.4 KOO28183.1 - 0.11 11.3 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Fea1 PF07692.6 KOO28184.1 - 0.0017 17.2 0.1 0.0029 16.4 0.1 1.5 1 1 0 1 1 1 1 Low iron-inducible periplasmic protein FAM163 PF15069.1 KOO28184.1 - 0.083 13.4 0.9 0.15 12.6 0.6 1.3 1 0 0 1 1 1 0 FAM163 family LRR19-TM PF15176.1 KOO28184.1 - 0.12 12.0 0.3 0.27 10.9 0.2 1.6 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain EMP70 PF02990.11 KOO28185.1 - 2.2e-169 564.2 11.8 2.7e-169 563.9 8.2 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 TMEM219 PF14940.1 KOO28185.1 - 0.026 13.6 0.7 0.049 12.7 0.5 1.3 1 0 0 1 1 1 0 Transmembrane 219 Actin PF00022.14 KOO28186.1 - 1.8e-93 313.1 0.0 2.3e-93 312.7 0.0 1.1 1 0 0 1 1 1 1 Actin DUF2413 PF10310.4 KOO28187.1 - 0.016 14.0 7.8 0.022 13.5 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) DUF572 PF04502.8 KOO28187.1 - 0.028 13.6 4.3 0.037 13.2 3.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) AvrE PF11725.3 KOO28187.1 - 0.046 10.7 5.1 0.051 10.6 3.5 1.0 1 0 0 1 1 1 0 Pathogenicity factor APG6 PF04111.7 KOO28187.1 - 0.15 11.0 10.5 0.21 10.6 7.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4615 PF15393.1 KOO28187.1 - 0.19 11.9 1.9 0.38 10.9 1.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4615) BOP1NT PF08145.7 KOO28187.1 - 0.41 10.3 2.3 0.57 9.8 1.6 1.1 1 0 0 1 1 1 0 BOP1NT (NUC169) domain PAT1 PF09770.4 KOO28187.1 - 0.41 8.8 11.2 0.48 8.6 7.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4557 PF15101.1 KOO28187.1 - 1.6 8.5 5.8 2.4 7.9 4.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) PCEMA1 PF07418.6 KOO28187.1 - 2.6 7.3 5.6 3.6 6.8 3.9 1.1 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 Snf7 PF03357.16 KOO28188.1 - 1.9e-58 196.6 85.3 6.3e-22 77.7 9.6 5.1 3 1 2 5 5 5 5 Snf7 DUF1247 PF06851.6 KOO28188.1 - 0.027 14.1 14.0 0.96 9.0 0.6 3.9 3 1 0 3 3 3 0 Protein of unknown function (DUF1247) ASL_C PF08328.6 KOO28188.1 - 0.056 13.2 19.6 0.9 9.3 2.2 4.6 4 0 0 4 4 4 0 Adenylosuccinate lyase C-terminal Syntaxin_2 PF14523.1 KOO28188.1 - 3.2 7.8 17.6 5.5 7.0 0.2 5.9 3 2 3 6 6 6 0 Syntaxin-like protein ABC1 PF03109.11 KOO28189.1 - 2.6e-29 101.5 0.0 6.8e-29 100.2 0.0 1.7 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 KOO28189.1 - 9.2e-05 22.2 0.3 9.2e-05 22.2 0.2 2.7 2 2 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.20 KOO28189.1 - 0.0013 17.9 0.0 0.26 10.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain RD3 PF14473.1 KOO28189.1 - 0.05 13.0 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 RD3 protein Peptidase_S8 PF00082.17 KOO28190.1 - 1.4e-31 109.7 6.0 5.2e-31 107.8 2.0 3.0 2 1 0 2 2 2 1 Subtilase family Methyltransf_23 PF13489.1 KOO28190.1 - 3.8e-18 65.7 0.0 7.4e-18 64.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain P_proprotein PF01483.15 KOO28190.1 - 3.3e-17 62.0 0.2 3.2e-08 33.2 0.0 2.6 2 0 0 2 2 2 2 Proprotein convertase P-domain Methyltransf_11 PF08241.7 KOO28190.1 - 8.8e-12 45.3 0.0 2.1e-11 44.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO28190.1 - 6.4e-08 32.0 0.0 1.1e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 KOO28190.1 - 1.1e-06 29.0 0.0 4.2e-06 27.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO28190.1 - 1.4e-05 25.3 0.0 4.2e-05 23.8 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO28190.1 - 0.00034 20.2 0.0 0.00098 18.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Fer4_15 PF13459.1 KOO28191.1 - 2.6e-13 50.3 3.9 2.6e-13 50.3 2.7 2.0 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_13 PF13370.1 KOO28191.1 - 4e-12 46.3 2.4 4e-12 46.3 1.7 1.9 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4 PF00037.22 KOO28191.1 - 0.012 15.2 3.4 0.31 10.7 0.4 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_21 PF14697.1 KOO28191.1 - 0.22 11.3 4.2 0.4 10.5 0.2 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_2 PF12797.2 KOO28191.1 - 4.6 7.3 6.5 0.29 11.1 0.4 2.0 2 0 0 2 2 2 0 4Fe-4S binding domain Sigma70_r2 PF04542.9 KOO28192.1 - 1.6e-13 50.0 0.0 4.5e-13 48.6 0.0 1.8 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r3 PF04539.11 KOO28192.1 - 2.9e-09 36.6 1.3 3e-08 33.4 0.4 2.4 2 0 0 2 2 2 1 Sigma-70 region 3 Sigma70_r4 PF04545.11 KOO28192.1 - 4.1e-07 29.1 4.1 0.011 15.0 0.2 3.6 3 0 0 3 3 3 3 Sigma-70, region 4 HTH_AsnC-type PF13404.1 KOO28192.1 - 0.00018 20.9 2.0 0.095 12.2 0.1 2.9 2 0 0 2 2 2 2 AsnC-type helix-turn-helix domain HTH_24 PF13412.1 KOO28192.1 - 0.0016 17.7 0.7 0.1 12.0 0.1 2.7 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_31 PF13560.1 KOO28192.1 - 0.012 15.7 8.1 0.78 9.9 0.3 2.9 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_10 PF04967.7 KOO28192.1 - 0.013 15.0 0.2 0.39 10.3 0.0 2.9 3 1 0 3 3 3 0 HTH DNA binding domain HTH_3 PF01381.17 KOO28192.1 - 0.051 13.4 0.6 7.6 6.4 0.1 2.4 2 0 0 2 2 2 0 Helix-turn-helix Kelch_3 PF13415.1 KOO28193.1 - 5.7e-27 93.2 6.5 7.9e-09 35.4 0.0 7.1 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.1 KOO28193.1 - 1.9e-22 78.7 3.3 8.3e-09 35.0 0.0 6.3 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO28193.1 - 1.5e-14 53.5 3.3 0.0013 18.5 0.0 5.6 6 0 0 6 6 6 2 Kelch motif Kelch_1 PF01344.20 KOO28193.1 - 8.5e-11 41.2 1.1 0.11 12.0 0.0 5.5 5 1 0 5 5 5 4 Kelch motif Kelch_6 PF13964.1 KOO28193.1 - 5.8e-09 35.7 1.3 9.4e-06 25.5 0.0 3.5 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.10 KOO28193.1 - 3.5e-05 23.3 1.0 2.9 7.7 0.0 4.7 5 0 0 5 5 5 2 Kelch motif RAG2 PF03089.9 KOO28193.1 - 0.014 14.1 0.0 0.68 8.5 0.0 2.5 2 0 0 2 2 2 0 Recombination activating protein 2 DUF1978 PF09321.5 KOO28194.1 - 0.0091 15.4 7.9 0.012 15.1 5.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1978) RNA_pol_Rpc82 PF05645.8 KOO28194.1 - 0.032 13.7 0.3 0.052 13.0 0.2 1.2 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 ParB PF08775.5 KOO28194.1 - 0.043 14.1 0.5 0.2 11.9 0.4 1.8 2 0 0 2 2 2 0 ParB family Fez1 PF06818.10 KOO28194.1 - 0.74 9.8 19.4 1.2 9.0 13.4 1.4 1 1 0 1 1 1 0 Fez1 DUF3584 PF12128.3 KOO28194.1 - 2.9 5.1 16.2 3.6 4.7 11.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Sel1 PF08238.7 KOO28196.1 - 4e-56 186.2 42.3 1.8e-07 31.5 0.2 9.7 9 0 0 9 9 9 9 Sel1 repeat U-box PF04564.10 KOO28196.1 - 1e-16 60.6 0.0 1.5e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO28196.1 - 0.00011 21.5 0.0 0.00021 20.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit TIG PF01833.19 KOO28197.1 - 1.5e-23 82.5 9.8 9.7e-05 22.2 0.0 7.3 6 1 0 6 6 6 6 IPT/TIG domain Anth_Ig PF05587.8 KOO28197.1 - 0.00092 19.0 0.0 0.052 13.3 0.0 3.6 5 0 0 5 5 5 1 Anthrax receptor extracellular domain DUF543 PF04418.7 KOO28198.1 - 1.2e-21 76.3 0.2 1.3e-21 76.2 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF543) zf-MYND PF01753.13 KOO28199.1 - 0.00051 19.8 8.7 0.0012 18.6 6.0 1.7 1 0 0 1 1 1 1 MYND finger zf-Mss51 PF13824.1 KOO28199.1 - 0.02 14.7 6.4 0.063 13.1 4.4 1.9 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Ribosomal_60s PF00428.14 KOO28199.1 - 3.9 7.9 10.6 9.6 6.6 7.3 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein TIG PF01833.19 KOO28200.1 - 0.0018 18.2 0.0 0.22 11.5 0.0 2.7 2 0 0 2 2 2 2 IPT/TIG domain DUF2458 PF10454.4 KOO28201.1 - 0.0046 16.8 2.0 0.0046 16.8 1.4 4.9 3 2 4 7 7 7 1 Protein of unknown function (DUF2458) Pho88 PF10032.4 KOO28202.1 - 1.4e-22 79.8 0.9 1.7e-22 79.6 0.6 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) Sel1 PF08238.7 KOO28203.1 - 6.8e-33 112.3 34.8 4.4e-08 33.5 1.0 7.0 6 0 0 6 6 6 6 Sel1 repeat U-box PF04564.10 KOO28203.1 - 9.7e-18 63.9 0.0 1.4e-17 63.3 0.0 1.3 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO28203.1 - 0.00014 21.3 0.0 0.00028 20.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit DUF4557 PF15101.1 KOO28203.1 - 7.6 6.3 9.8 0.37 10.6 2.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4557) TIG PF01833.19 KOO28204.1 - 1.1e-23 82.9 29.8 4.6e-08 32.9 0.1 7.8 8 1 1 9 9 9 5 IPT/TIG domain REJ PF02010.10 KOO28204.1 - 1.5e-08 33.4 0.0 9e-07 27.5 0.0 2.2 1 1 1 2 2 2 2 REJ domain Qn_am_d_aIII PF09099.5 KOO28204.1 - 1.2 9.4 8.7 5.5 7.3 0.5 4.7 5 0 0 5 5 5 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain III TatD_DNase PF01026.16 KOO28205.1 - 1.1e-33 116.4 0.0 2.1e-33 115.6 0.0 1.5 1 0 0 1 1 1 1 TatD related DNase ThiF PF00899.16 KOO28205.1 - 9.1e-31 106.4 0.4 9.1e-31 106.4 0.3 1.7 2 0 0 2 2 2 1 ThiF family NAD_binding_7 PF13241.1 KOO28205.1 - 0.0037 17.4 0.4 0.0096 16.1 0.2 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding ELFV_dehydrog PF00208.16 KOO28205.1 - 0.014 15.0 0.0 0.026 14.0 0.0 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 3HCDH_N PF02737.13 KOO28205.1 - 0.087 12.4 0.1 0.087 12.4 0.1 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.9 KOO28205.1 - 0.095 12.5 0.2 0.17 11.7 0.2 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.15 KOO28205.1 - 0.13 12.3 0.1 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Glyco_transf_8 PF01501.15 KOO28206.1 - 9.6e-10 38.2 0.0 1.5e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 EF-hand_6 PF13405.1 KOO28207.1 - 1.7e-19 67.8 10.0 2.5e-05 23.7 0.3 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.27 KOO28207.1 - 4.4e-19 66.2 10.4 4.9e-05 22.3 0.2 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO28207.1 - 7.5e-19 67.6 1.8 7.1e-09 35.6 0.1 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO28207.1 - 6.5e-15 54.4 1.4 6.6e-07 28.8 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO28207.1 - 2.7e-12 45.4 13.9 2.3e-05 23.4 0.3 4.3 4 0 0 4 4 4 3 EF hand SPARC_Ca_bdg PF10591.4 KOO28207.1 - 0.014 15.4 0.1 3.7 7.6 0.0 3.1 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOO28207.1 - 0.029 14.3 0.0 14 5.6 0.0 3.0 4 0 0 4 4 4 0 EF-hand domain Armet PF10208.4 KOO28207.1 - 0.087 12.4 0.0 0.39 10.3 0.0 1.9 2 0 0 2 2 2 0 Degradation arginine-rich protein for mis-folding EF-hand_10 PF14788.1 KOO28207.1 - 0.11 12.1 3.8 0.82 9.3 0.0 3.2 4 0 0 4 4 4 0 EF hand EF-hand_4 PF12763.2 KOO28207.1 - 0.48 10.1 3.2 4.2 7.1 0.0 2.8 3 0 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand UFD1 PF03152.9 KOO28208.1 - 5.1e-40 136.4 0.0 6.9e-40 136.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 CAP_GLY PF01302.20 KOO28208.1 - 2.1e-21 75.4 1.2 4.2e-21 74.4 0.8 1.6 1 0 0 1 1 1 1 CAP-Gly domain UBX PF00789.15 KOO28208.1 - 5e-16 58.5 0.0 9e-16 57.7 0.0 1.4 1 0 0 1 1 1 1 UBX domain CDC48_2 PF02933.12 KOO28208.1 - 0.054 13.1 0.6 0.17 11.5 0.5 1.7 2 0 0 2 2 2 0 Cell division protein 48 (CDC48), domain 2 DUF2878 PF11086.3 KOO28208.1 - 0.11 12.5 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2878) CBF PF03914.12 KOO28209.1 - 3.4e-41 140.4 0.0 8.6e-41 139.1 0.0 1.7 1 0 0 1 1 1 1 CBF/Mak21 family Adaptin_N PF01602.15 KOO28210.1 - 2.9e-38 131.5 0.0 3.6e-38 131.1 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 KOO28210.1 - 0.012 15.8 11.1 0.039 14.2 0.3 3.6 2 1 1 3 3 3 0 HEAT repeats HEAT PF02985.17 KOO28210.1 - 0.033 14.2 2.0 0.29 11.3 0.1 3.3 2 0 0 2 2 2 0 HEAT repeat Arm PF00514.18 KOO28210.1 - 2.8 7.8 6.4 0.79 9.6 0.2 3.1 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Mito_carr PF00153.22 KOO28213.1 - 3.7e-33 113.0 2.9 1.9e-17 62.7 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Gly_transf_sug PF04488.10 KOO28215.1 - 1.6e-09 38.0 0.0 3.2e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif ShK PF01549.19 KOO28215.1 - 2.6e-09 37.2 8.0 2.6e-09 37.2 5.5 1.9 2 0 0 2 2 2 1 ShK domain-like TcdA_TcdB PF12919.2 KOO28215.1 - 0.00074 18.1 0.0 0.0011 17.5 0.0 1.1 1 0 0 1 1 1 1 TcdA/TcdB catalytic glycosyltransferase domain Caps_synth PF05704.7 KOO28215.1 - 0.0047 16.1 0.0 0.0064 15.6 0.0 1.1 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein 6PF2K PF01591.13 KOO28217.1 - 5.6e-38 130.2 0.3 1.7e-28 99.2 0.0 2.1 1 1 1 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 KOO28217.1 - 2.7e-12 47.0 0.0 2.1e-11 44.1 0.0 2.3 1 1 1 2 2 2 1 Histidine phosphatase superfamily (branch 1) AAA_17 PF13207.1 KOO28217.1 - 0.0053 17.5 0.0 0.014 16.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 KOO28217.1 - 0.0064 16.3 0.2 0.03 14.2 0.1 2.0 1 1 0 1 1 1 1 AAA domain DUF3274 PF11678.3 KOO28217.1 - 0.04 13.1 0.0 0.065 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3274) Redoxin PF08534.5 KOO28218.1 - 2.2e-14 53.2 0.1 3.8e-14 52.4 0.0 1.4 1 0 0 1 1 1 1 Redoxin Ank_4 PF13637.1 KOO28220.1 - 0.022 15.2 0.0 0.49 10.9 0.0 2.2 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO28220.1 - 0.051 13.9 0.1 0.13 12.5 0.0 1.9 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO28220.1 - 0.074 13.3 0.0 1.3 9.4 0.0 2.6 3 0 0 3 3 3 0 Ankyrin repeat CDC37_C PF08564.5 KOO28222.1 - 4.4e-24 84.2 1.0 1.7e-12 47.0 0.0 2.8 3 0 0 3 3 3 2 Cdc37 C terminal domain Lzipper-MIP1 PF14389.1 KOO28222.1 - 0.017 15.2 2.5 0.017 15.2 1.7 2.1 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 SOBP PF15279.1 KOO28222.1 - 0.56 10.5 2.2 0.58 10.4 0.9 1.5 1 1 0 1 1 1 0 Sine oculis-binding protein Vps39_2 PF10367.4 KOO28222.1 - 1.1 9.4 4.1 23 5.2 0.0 3.2 3 1 0 3 3 3 0 Vacuolar sorting protein 39 domain 2 APG6 PF04111.7 KOO28222.1 - 2.2 7.2 6.7 3.4 6.6 4.7 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Cnd1_N PF12922.2 KOO28222.1 - 3.6 7.1 6.4 3.7 7.1 3.2 1.9 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term Macoilin PF09726.4 KOO28222.1 - 7.6 4.6 8.5 11 4.2 5.9 1.2 1 0 0 1 1 1 0 Transmembrane protein DUF4404 PF14357.1 KOO28222.1 - 7.9 6.9 8.3 14 6.2 4.9 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) DNA_topoisoIV PF00521.15 KOO28224.1 - 8.3e-140 466.3 0.0 9.9e-140 466.1 0.0 1.1 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseA_C PF03989.8 KOO28224.1 - 1.6e-19 68.8 0.0 5.3e-07 28.8 0.0 4.4 4 0 0 4 4 4 3 DNA gyrase C-terminal domain, beta-propeller LigA PF07746.6 KOO28224.1 - 0.029 14.3 0.2 0.077 13.0 0.1 1.7 1 0 0 1 1 1 0 Aromatic-ring-opening dioxygenase LigAB, LigA subunit DNA_gyraseA_C PF03989.8 KOO28225.1 - 2.7e-23 80.9 0.2 1.8e-11 43.1 0.0 2.1 2 0 0 2 2 2 2 DNA gyrase C-terminal domain, beta-propeller TPR_11 PF13414.1 KOO28226.1 - 4.2e-13 48.7 5.0 6.8e-10 38.4 2.4 2.9 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 KOO28226.1 - 1.7e-10 39.9 7.9 0.012 15.5 0.3 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO28226.1 - 1.4e-09 37.1 2.7 0.013 15.1 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOO28226.1 - 8.9e-06 25.5 3.5 0.014 15.3 2.2 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO28226.1 - 0.00011 22.7 8.2 0.00011 22.7 5.7 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO28226.1 - 0.00027 20.4 0.2 3.6 7.5 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO28226.1 - 0.00032 20.6 0.6 0.3 11.4 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28226.1 - 0.026 15.1 2.8 0.026 15.1 1.9 4.8 4 1 1 5 5 4 0 Tetratricopeptide repeat MscS_porin PF12795.2 KOO28226.1 - 0.048 12.9 0.0 0.078 12.2 0.0 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain TPR_9 PF13371.1 KOO28226.1 - 0.1 12.4 17.0 0.08 12.8 0.8 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO28226.1 - 0.12 12.8 4.7 30 5.3 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat ABC_tran PF00005.22 KOO28227.1 - 1.3e-29 103.2 0.0 3e-29 102.0 0.0 1.6 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.1 KOO28227.1 - 6e-12 46.1 0.1 1e-05 25.6 0.0 2.2 1 1 0 2 2 2 2 AAA domain SMC_N PF02463.14 KOO28227.1 - 3.3e-07 29.7 0.1 3.6e-05 23.0 0.1 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain Dynamin_N PF00350.18 KOO28227.1 - 3.1e-05 23.8 0.0 5.2e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Dynamin family ABC_tran_2 PF12848.2 KOO28227.1 - 0.00012 21.8 0.1 0.00031 20.5 0.1 1.7 1 0 0 1 1 1 1 ABC transporter Miro PF08477.8 KOO28227.1 - 0.0002 21.8 0.0 0.00048 20.6 0.0 1.7 2 0 0 2 2 1 1 Miro-like protein AAA_29 PF13555.1 KOO28227.1 - 0.00079 18.9 0.0 0.0016 17.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.1 KOO28227.1 - 0.00084 19.7 0.5 0.0018 18.6 0.3 1.9 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO28227.1 - 0.0025 18.6 0.0 0.0065 17.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 KOO28227.1 - 0.0045 16.9 0.0 0.017 15.0 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_14 PF13173.1 KOO28227.1 - 0.0065 16.3 0.0 0.051 13.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_10 PF12846.2 KOO28227.1 - 0.0074 15.7 0.2 0.023 14.1 0.1 2.0 1 1 1 2 2 2 1 AAA-like domain AAA_22 PF13401.1 KOO28227.1 - 0.0085 16.2 0.1 0.018 15.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOO28227.1 - 0.0094 15.9 0.0 0.016 15.2 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.1 KOO28227.1 - 0.014 14.4 0.0 3.3 6.6 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.1 KOO28227.1 - 0.02 15.2 0.0 0.073 13.3 0.0 2.1 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.11 KOO28227.1 - 0.028 13.5 0.0 0.042 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_28 PF13521.1 KOO28227.1 - 0.041 13.8 0.3 0.1 12.5 0.2 2.0 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.17 KOO28227.1 - 0.051 12.4 0.0 0.075 11.8 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain cobW PF02492.14 KOO28227.1 - 0.058 12.8 0.0 0.88 8.9 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.1 KOO28227.1 - 0.059 12.9 0.1 0.22 11.0 0.0 1.9 1 1 0 1 1 1 0 AAA domain GTP_EFTU PF00009.22 KOO28227.1 - 0.079 12.3 0.0 0.38 10.1 0.0 1.8 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain DUF87 PF01935.12 KOO28227.1 - 0.085 12.6 0.0 0.37 10.5 0.0 1.9 2 1 0 2 2 2 0 Domain of unknown function DUF87 NACHT PF05729.7 KOO28227.1 - 0.087 12.4 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_33 PF13671.1 KOO28227.1 - 0.096 12.5 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.1 KOO28227.1 - 0.096 12.6 0.0 1.3 9.0 0.0 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_13 PF13166.1 KOO28227.1 - 0.1 11.0 0.0 0.44 8.9 0.0 1.8 1 1 0 2 2 2 0 AAA domain AAA_25 PF13481.1 KOO28227.1 - 0.13 11.6 0.2 0.66 9.3 0.2 2.4 1 1 0 1 1 1 0 AAA domain LRR_6 PF13516.1 KOO28228.1 - 2.6e-16 57.7 20.3 0.00072 19.3 0.2 7.6 7 1 0 7 7 7 5 Leucine Rich repeat LRR_4 PF12799.2 KOO28228.1 - 4.8e-05 22.8 6.6 0.37 10.4 0.0 4.9 5 1 0 5 5 5 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO28228.1 - 5.2e-05 22.7 4.0 4.5 7.7 0.0 6.2 7 0 0 7 7 7 1 Leucine Rich Repeat LRR_8 PF13855.1 KOO28228.1 - 0.57 9.9 10.9 5.2 6.9 0.0 4.6 4 1 0 4 4 4 0 Leucine rich repeat DUF676 PF05057.9 KOO28230.1 - 5.6e-20 71.5 0.0 1.5e-19 70.1 0.0 1.6 1 1 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.8 KOO28230.1 - 3.3e-05 23.5 0.0 5.3e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_5 PF12695.2 KOO28230.1 - 8.6e-05 22.3 0.0 0.00019 21.2 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.20 KOO28230.1 - 0.0041 16.7 0.0 0.0067 16.0 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) MMR_HSR1 PF01926.18 KOO28232.1 - 6.2e-18 64.8 0.1 1.6e-15 57.0 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KOO28232.1 - 2.8e-11 42.9 0.0 6.3e-09 35.2 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B DUF258 PF03193.11 KOO28232.1 - 0.00036 19.7 0.1 0.00082 18.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Miro PF08477.8 KOO28232.1 - 0.0028 18.1 0.0 0.19 12.2 0.0 2.5 2 0 0 2 2 2 1 Miro-like protein GTP_EFTU PF00009.22 KOO28232.1 - 0.0045 16.4 0.0 0.86 9.0 0.0 3.0 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 KOO28232.1 - 0.005 16.6 0.2 0.086 12.6 0.1 2.5 2 1 0 2 2 2 1 Dynamin family SRPRB PF09439.5 KOO28232.1 - 0.033 13.4 0.0 0.065 12.4 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AIG1 PF04548.11 KOO28232.1 - 0.038 13.0 0.1 0.066 12.3 0.1 1.3 1 0 0 1 1 1 0 AIG1 family MobB PF03205.9 KOO28232.1 - 0.066 12.9 0.1 0.18 11.5 0.1 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.14 KOO28232.1 - 0.11 11.9 0.1 4.4 6.7 0.0 2.8 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DEAD PF00270.24 KOO28233.1 - 1.5e-38 131.9 0.1 2.8e-38 131.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO28233.1 - 1e-26 92.5 0.2 2.3e-26 91.4 0.2 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF1253 PF06862.7 KOO28233.1 - 0.0063 14.9 0.0 0.39 9.0 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1253) ResIII PF04851.10 KOO28233.1 - 0.053 13.3 0.1 0.098 12.4 0.1 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_19 PF13245.1 KOO28233.1 - 0.065 12.9 0.2 0.21 11.3 0.1 1.8 1 0 0 1 1 1 0 Part of AAA domain CMS1 PF14617.1 KOO28233.1 - 0.088 11.8 0.0 0.26 10.2 0.0 1.7 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Kinesin PF00225.18 KOO28234.1 - 1.5e-101 339.4 0.0 2.1e-101 339.0 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain ABC1 PF03109.11 KOO28235.1 - 5.9e-16 58.5 0.1 1.7e-15 57.0 0.0 1.7 2 0 0 2 2 2 1 ABC1 family Pkinase PF00069.20 KOO28235.1 - 0.04 13.0 0.0 0.13 11.4 0.0 1.7 2 0 0 2 2 2 0 Protein kinase domain RIO1 PF01163.17 KOO28235.1 - 0.11 11.8 0.0 0.61 9.3 0.0 2.2 3 0 0 3 3 3 0 RIO1 family TauD PF02668.11 KOO28236.1 - 8.4e-40 137.0 0.1 1.7e-39 136.0 0.0 1.5 2 0 0 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family EF-hand_1 PF00036.27 KOO28236.1 - 1.8e-12 45.5 0.7 2.5e-05 23.2 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO28236.1 - 1.7e-10 40.8 0.0 3.3e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO28236.1 - 8.5e-09 34.5 0.4 0.0017 18.1 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO28236.1 - 1.2e-08 33.8 0.8 0.00064 18.9 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO28236.1 - 1.2e-07 31.2 0.2 0.012 15.1 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair CsiD PF08943.5 KOO28236.1 - 0.016 14.0 0.0 0.032 13.1 0.0 1.4 1 0 0 1 1 1 0 CsiD WD40 PF00400.27 KOO28237.1 - 5.4e-66 216.2 18.2 2.9e-13 49.1 0.1 5.2 5 0 0 5 5 5 5 WD domain, G-beta repeat PD40 PF07676.7 KOO28237.1 - 6.2e-13 48.1 2.0 0.68 9.6 0.0 5.4 5 0 0 5 5 5 5 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOO28237.1 - 1.2e-05 25.1 0.2 0.0055 16.4 0.0 2.7 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A DUF3312 PF11768.3 KOO28237.1 - 8.5e-05 20.9 0.0 0.53 8.4 0.0 3.0 1 1 2 3 3 3 3 Protein of unknown function (DUF3312) Gmad1 PF10647.4 KOO28237.1 - 0.0047 16.3 0.2 13 5.1 0.0 3.9 2 1 1 4 4 4 1 Lipoprotein LpqB beta-propeller domain IKI3 PF04762.7 KOO28237.1 - 0.0073 14.1 0.4 0.029 12.2 0.2 2.0 1 1 0 1 1 1 1 IKI3 family rOmpB PF12334.3 KOO28237.1 - 0.03 13.7 0.6 4.4 6.6 0.1 3.4 3 1 1 4 4 4 0 Rickettsia outer membrane protein B Dfp1_Him1_M PF08630.5 KOO28237.1 - 0.28 10.9 5.7 3.1 7.6 0.0 3.3 4 1 1 5 5 5 0 Dfp1/Him1, central region RED_C PF07807.6 KOO28237.1 - 0.41 10.8 3.3 24 5.1 0.0 3.6 3 1 2 5 5 5 0 RED-like protein C-terminal region Antimicrobial_7 PF08102.6 KOO28237.1 - 0.76 9.8 5.9 71 3.5 0.0 4.8 5 0 0 5 5 5 0 Scorpion antimicrobial peptide Proteasome_A_N PF10584.4 KOO28237.1 - 2 7.8 10.8 12 5.3 0.3 4.7 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Ras PF00071.17 KOO28240.1 - 1.7e-40 138.0 0.0 2.1e-40 137.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO28240.1 - 4e-16 59.5 0.0 5.1e-16 59.2 0.0 1.1 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO28240.1 - 2.6e-08 33.2 0.0 3.3e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 KOO28240.1 - 5.7e-05 23.0 0.0 7.9e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 KOO28240.1 - 0.00061 19.2 0.0 0.0013 18.2 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 KOO28240.1 - 0.015 14.4 0.0 0.017 14.3 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DNA_pol_E_B PF04042.11 KOO28240.1 - 0.074 12.2 0.0 0.097 11.9 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B Apc5 PF12862.2 KOO28241.1 - 0.00013 21.6 14.2 0.0025 17.5 0.8 3.3 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 5 SET PF00856.23 KOO28242.1 - 4.7e-11 43.2 0.1 1.5e-05 25.4 0.0 3.2 3 1 0 3 3 3 2 SET domain HypA PF01155.14 KOO28242.1 - 0.7 9.6 6.5 2.6 7.7 0.2 2.9 3 0 0 3 3 3 0 Hydrogenase expression/synthesis hypA family Mito_carr PF00153.22 KOO28243.1 - 2.3e-65 216.3 7.5 6.9e-22 76.9 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein tRNA-synt_2d PF01409.15 KOO28244.1 - 3.4e-55 186.9 0.0 8.2e-31 107.0 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.9 KOO28244.1 - 6.4e-24 83.9 0.0 1.3e-23 82.9 0.0 1.6 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain DUF2070 PF09843.4 KOO28244.1 - 0.041 13.3 0.0 0.08 12.4 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) tRNA-synt_2 PF00152.15 KOO28244.1 - 0.044 12.5 0.3 7 5.3 0.0 2.5 3 0 0 3 3 3 0 tRNA synthetases class II (D, K and N) Dynein_heavy PF03028.10 KOO28245.1 - 3.6e-193 643.4 0.0 5e-193 642.9 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor AAA_8 PF12780.2 KOO28245.1 - 2.1e-106 354.8 0.0 3.3e-106 354.1 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 KOO28245.1 - 3.3e-84 281.2 0.8 6e-84 280.4 0.2 1.8 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 AAA_7 PF12775.2 KOO28245.1 - 1.1e-80 270.6 0.1 1.9e-80 269.8 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 MT PF12777.2 KOO28245.1 - 1e-59 202.0 12.9 1.7e-59 201.3 8.9 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_6 PF12774.2 KOO28245.1 - 1.1e-31 110.1 0.0 3e-31 108.7 0.0 1.8 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_5 PF07728.9 KOO28245.1 - 7.3e-15 54.9 0.1 2e-07 30.8 0.0 3.8 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOO28245.1 - 0.047 13.6 2.0 5.2 7.0 0.0 3.7 4 0 0 4 4 4 0 AAA ATPase domain Pox_A32 PF04665.7 KOO28245.1 - 0.054 12.7 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Poxvirus A32 protein WTX PF09422.5 KOO28245.1 - 4.6 6.0 0.7 7.1 5.4 0.5 1.1 1 0 0 1 1 1 0 WTX protein DMP1 PF07263.6 KOO28245.1 - 6.6 5.3 0.2 11 4.5 0.2 1.2 1 0 0 1 1 1 0 Dentin matrix protein 1 (DMP1) Exostosin PF03016.10 KOO28246.1 - 2.9e-18 65.9 0.0 4.2e-18 65.4 0.0 1.2 1 0 0 1 1 1 1 Exostosin family Nuc_sug_transp PF04142.10 KOO28248.1 - 6.5e-70 235.0 9.0 1e-69 234.3 6.3 1.3 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.15 KOO28248.1 - 9.9e-07 28.8 4.6 9.9e-07 28.8 3.2 3.2 3 1 0 3 3 3 1 EamA-like transporter family UAA PF08449.6 KOO28248.1 - 5.9e-06 25.4 12.3 8.3e-06 24.9 8.5 1.3 1 1 0 1 1 1 1 UAA transporter family TPT PF03151.11 KOO28248.1 - 7.1e-06 25.7 6.5 7.1e-06 25.7 4.5 3.4 2 1 0 2 2 2 1 Triose-phosphate Transporter family EmrE PF13536.1 KOO28248.1 - 3.8e-05 23.8 4.1 3.8e-05 23.8 2.8 3.4 2 1 1 3 3 3 1 Multidrug resistance efflux transporter DEAD PF00270.24 KOO28249.1 - 1.3e-17 63.8 0.1 2.3e-17 63.0 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO28249.1 - 3.5e-09 36.3 0.0 8.4e-09 35.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain LpxB PF02684.10 KOO28249.1 - 6.2e-08 31.6 0.0 0.0034 16.0 0.0 2.3 1 1 1 2 2 2 2 Lipid-A-disaccharide synthetase ResIII PF04851.10 KOO28249.1 - 0.029 14.2 0.0 0.057 13.2 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Pkinase PF00069.20 KOO28250.1 - 1.7e-35 122.4 0.0 2.4e-35 121.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO28250.1 - 2.8e-32 111.7 0.0 4.1e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO28250.1 - 0.00042 20.1 0.5 0.0037 17.0 0.1 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family Imm42 PF15601.1 KOO28250.1 - 0.027 13.8 0.0 0.049 13.0 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 42 Mak10 PF04112.8 KOO28251.1 - 5.6e-24 84.2 0.0 1.9e-23 82.5 0.0 1.8 1 1 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase GDA1_CD39 PF01150.12 KOO28252.1 - 1e-74 251.6 0.0 1.3e-74 251.2 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Plus-3 PF03126.13 KOO28255.1 - 2.7e-18 65.9 0.0 1e-17 64.1 0.0 1.8 1 1 1 2 2 2 1 Plus-3 domain DUF563 PF04577.9 KOO28256.1 - 9.5e-19 68.1 0.3 6.1e-18 65.4 0.2 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF563) L31 PF09784.4 KOO28256.1 - 0.11 12.5 0.9 4.1 7.5 0.0 3.0 3 1 0 3 3 3 0 Mitochondrial ribosomal protein L31 HET PF06985.6 KOO28257.1 - 0.1 12.7 0.3 1.9 8.6 0.0 2.7 2 1 1 3 3 3 0 Heterokaryon incompatibility protein (HET) DEAD PF00270.24 KOO28258.1 - 1.1e-20 73.8 0.0 1.7e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 KOO28258.1 - 3.4e-16 59.6 0.0 8.2e-16 58.3 0.0 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Metallophos PF00149.23 KOO28259.1 - 0.04 13.3 0.0 0.073 12.4 0.0 1.6 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase FAST_1 PF06743.10 KOO28260.1 - 2e-12 46.6 0.0 0.16 11.7 0.0 5.6 1 1 5 6 6 6 4 FAST kinase-like protein, subdomain 1 DUF1601 PF07671.6 KOO28260.1 - 2.1e-05 24.0 2.0 0.25 11.0 0.1 5.2 4 2 2 6 6 6 1 Protein of unknown function (DUF1601) TPR_17 PF13431.1 KOO28260.1 - 0.048 13.8 3.1 4.7 7.6 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Phage_holin_5 PF06946.6 KOO28260.1 - 1.1 9.4 13.0 0.63 10.2 0.2 4.4 1 1 3 5 5 5 0 Phage holin Helicase_C_3 PF13625.1 KOO28260.1 - 3.5 7.3 6.6 11 5.8 0.1 3.4 3 2 1 4 4 4 0 Helicase conserved C-terminal domain DUF2291 PF10054.4 KOO28260.1 - 6.7 5.9 12.6 13 5.0 0.2 3.8 2 2 2 4 4 4 0 Predicted periplasmic lipoprotein (DUF2291) SKI PF01202.17 KOO28261.1 - 1e-25 90.4 0.0 1.9e-25 89.6 0.0 1.4 1 0 0 1 1 1 1 Shikimate kinase DHquinase_I PF01487.10 KOO28261.1 - 6e-22 78.4 0.0 2.1e-18 66.8 0.0 2.2 2 0 0 2 2 2 2 Type I 3-dehydroquinase AAA_17 PF13207.1 KOO28261.1 - 8.6e-08 33.0 0.0 2.3e-07 31.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 KOO28261.1 - 0.00098 19.0 0.2 0.0039 17.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 KOO28261.1 - 0.064 13.4 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Acetyltransf_1 PF00583.19 KOO28263.1 - 2.6e-14 52.9 0.0 3.9e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 KOO28263.1 - 2.9e-06 27.3 0.0 5.2e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 KOO28263.1 - 4.2e-05 23.6 0.0 7e-05 22.9 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 KOO28263.1 - 0.0043 16.7 0.0 0.007 16.0 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein HAD_2 PF13419.1 KOO28264.1 - 2.5e-22 79.9 0.0 3.1e-22 79.6 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOO28264.1 - 4.4e-09 35.9 0.1 3.9e-07 29.6 0.0 2.3 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.21 KOO28264.1 - 1e-07 32.6 0.0 2.4e-07 31.3 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO28264.1 - 0.00043 20.5 0.0 0.0005 20.2 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.1 KOO28264.1 - 0.0066 16.3 0.0 0.069 13.0 0.0 2.4 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Phage_integrase PF00589.17 KOO28265.1 - 0.13 11.9 0.0 0.28 10.8 0.0 1.6 1 0 0 1 1 1 0 Phage integrase family Dam PF05869.6 KOO28265.1 - 0.19 11.1 0.0 0.33 10.3 0.0 1.3 1 0 0 1 1 1 0 DNA N-6-adenine-methyltransferase (Dam) Ion_trans_2 PF07885.11 KOO28266.1 - 4.2e-15 55.2 1.6 7.4e-15 54.4 1.1 1.4 1 0 0 1 1 1 1 Ion channel EF-hand_6 PF13405.1 KOO28266.1 - 2.7e-05 23.6 1.4 0.00092 18.9 0.1 2.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.1 KOO28266.1 - 3.9e-05 22.8 4.7 0.0013 17.9 0.7 2.5 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.27 KOO28266.1 - 0.00017 20.6 1.9 0.013 14.7 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO28266.1 - 0.00036 20.6 2.1 0.11 12.7 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO28266.1 - 0.017 14.7 0.8 2.2 7.9 0.1 2.6 2 0 0 2 2 2 0 EF-hand domain pair Mito_fiss_reg PF05308.6 KOO28266.1 - 0.39 10.0 2.5 0.59 9.4 1.7 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator DEAD PF00270.24 KOO28268.1 - 7.9e-17 61.2 0.0 5.3e-16 58.5 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO28268.1 - 2.8e-16 59.1 0.0 9.1e-16 57.4 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SPX PF03105.14 KOO28269.1 - 4.9e-10 39.6 1.7 1.8e-08 34.5 1.2 2.0 1 1 0 1 1 1 1 SPX domain UAA PF08449.6 KOO28270.1 - 3.4e-12 45.8 19.2 4.7e-12 45.4 13.0 1.6 1 1 0 1 1 1 1 UAA transporter family TPT PF03151.11 KOO28270.1 - 2.3e-11 43.5 11.2 2.3e-11 43.5 7.8 2.4 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 KOO28270.1 - 7.8e-07 29.1 6.5 7.8e-07 29.1 4.5 3.4 2 2 1 3 3 3 1 EamA-like transporter family Pox_A14 PF05767.7 KOO28270.1 - 0.0075 16.2 0.4 0.1 12.6 0.2 2.6 2 0 0 2 2 2 1 Poxvirus virion envelope protein A14 DUF4231 PF14015.1 KOO28270.1 - 3.5 7.6 6.6 18 5.3 0.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) 6PF2K PF01591.13 KOO28271.1 - 8.8e-49 165.5 0.0 1.3e-48 165.0 0.0 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_33 PF13671.1 KOO28271.1 - 0.0072 16.2 0.1 0.019 14.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain His_Phos_1 PF00300.17 KOO28271.1 - 0.025 14.6 0.1 0.3 11.1 0.0 2.7 2 1 0 2 2 2 0 Histidine phosphatase superfamily (branch 1) Mito_carr PF00153.22 KOO28272.1 - 1.3e-48 162.6 7.9 1.9e-19 69.1 0.3 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein CLP_protease PF00574.18 KOO28273.1 - 7.1e-51 172.4 0.0 1.1e-50 171.7 0.0 1.3 1 0 0 1 1 1 1 Clp protease TGT PF01702.13 KOO28274.1 - 2e-52 177.8 0.0 2.2e-52 177.7 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Filamin PF00630.14 KOO28275.1 - 7.5e-08 32.8 0.0 0.019 15.5 0.0 2.3 2 0 0 2 2 2 2 Filamin/ABP280 repeat PPC PF04151.10 KOO28275.1 - 0.16 12.9 0.3 3.4 8.7 0.1 2.7 3 0 0 3 3 3 0 Bacterial pre-peptidase C-terminal domain Lipocalin_6 PF13944.1 KOO28275.1 - 0.31 11.1 2.6 0.69 10.0 0.3 2.5 3 0 0 3 3 3 0 Lipocalin-like domain Sec2p PF06428.6 KOO28277.1 - 2.8 7.8 7.8 0.81 9.5 3.4 1.7 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p ACT_7 PF13840.1 KOO28279.1 - 3.1e-15 55.4 0.1 6.2e-07 28.8 0.0 2.7 3 0 0 3 3 3 2 ACT domain Sds3 PF08598.6 KOO28280.1 - 0.62 9.5 14.3 0.78 9.2 9.9 1.3 1 1 0 1 1 1 0 Sds3-like Atg14 PF10186.4 KOO28280.1 - 3.4 6.5 11.5 4.1 6.2 8.0 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Mnd1 PF03962.10 KOO28280.1 - 6.1 6.4 13.3 9.6 5.8 9.2 1.3 1 0 0 1 1 1 0 Mnd1 family FUSC PF04632.7 KOO28280.1 - 8 4.7 8.0 10 4.3 5.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family RRM_6 PF14259.1 KOO28281.1 - 5.2e-24 84.0 0.0 1.7e-09 37.5 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOO28281.1 - 3e-23 81.2 0.0 1.3e-07 31.1 0.0 3.6 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO28281.1 - 3.9e-16 58.6 0.3 9.5e-06 25.3 0.0 3.7 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Surp PF01805.15 KOO28281.1 - 0.00017 21.1 0.0 0.00029 20.4 0.0 1.4 1 0 0 1 1 1 1 Surp module Kri1_C PF12936.2 KOO28281.1 - 0.15 11.9 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 KRI1-like family C-terminal MRP-S23 PF10484.4 KOO28282.1 - 0.00018 21.3 0.1 0.00042 20.2 0.1 1.6 1 1 0 1 1 1 1 Mitochondrial ribosomal protein S23 UPF0181 PF03701.9 KOO28282.1 - 0.055 12.7 0.5 0.14 11.4 0.1 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0181) MRP-S25 PF13741.1 KOO28282.1 - 0.27 10.6 10.4 3.2 7.1 4.5 2.6 1 1 1 2 2 2 0 Mitochondrial ribosomal protein S25 Ank_2 PF12796.2 KOO28283.1 - 3.6e-33 113.7 5.2 7e-15 55.1 0.2 3.4 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO28283.1 - 1.5e-29 100.2 8.1 5.8e-05 22.6 0.3 6.3 5 1 1 6 6 6 6 Ankyrin repeat Ank_4 PF13637.1 KOO28283.1 - 1.4e-28 98.6 4.4 2.8e-08 34.0 0.0 4.5 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO28283.1 - 7.3e-23 80.0 4.7 4.3e-07 29.9 0.1 5.5 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO28283.1 - 1.7e-22 77.2 1.9 0.00074 19.5 0.0 6.7 6 1 0 6 6 6 5 Ankyrin repeat CENP-X PF09415.5 KOO28284.1 - 0.099 12.4 0.2 0.32 10.8 0.1 1.9 1 0 0 1 1 1 0 CENP-S associating Centromere protein X TPR_11 PF13414.1 KOO28286.1 - 7.3e-10 38.3 5.5 1.3e-05 24.7 0.2 2.5 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 KOO28286.1 - 4.7e-08 32.3 1.1 0.00039 20.1 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO28286.1 - 1.1e-06 27.9 0.1 0.071 12.7 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO28286.1 - 3.6e-06 27.4 1.4 3.6e-06 27.4 1.0 2.0 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28286.1 - 0.00013 22.2 1.0 0.072 13.7 0.3 3.0 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.1 KOO28286.1 - 0.00028 21.1 2.3 0.95 10.0 0.0 3.5 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO28286.1 - 0.00043 20.1 0.6 0.0012 18.6 0.4 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO28286.1 - 0.00057 20.1 7.6 0.00087 19.5 0.3 3.5 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO28286.1 - 0.0011 18.8 3.2 0.0043 16.8 0.4 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO28286.1 - 0.0023 17.5 0.0 0.6 10.0 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO28286.1 - 0.0036 16.9 2.1 0.039 13.7 0.1 2.9 2 1 1 3 3 2 1 Tetratricopeptide repeat MIT PF04212.13 KOO28286.1 - 0.015 15.1 0.5 0.091 12.6 0.3 2.5 1 1 1 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_4 PF07721.9 KOO28286.1 - 0.021 15.2 4.4 2.1 8.9 0.9 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat PP28 PF10252.4 KOO28286.1 - 0.031 14.2 0.1 0.031 14.2 0.1 2.2 2 0 0 2 2 2 0 Casein kinase substrate phosphoprotein PP28 Apc3 PF12895.2 KOO28286.1 - 0.037 14.1 1.3 0.074 13.1 0.9 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.1 KOO28286.1 - 0.16 11.9 3.2 3.2 7.8 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat EF-hand_8 PF13833.1 KOO28286.1 - 0.2 11.2 3.9 7.2 6.3 0.2 3.4 2 0 0 2 2 2 0 EF-hand domain pair TPR_21 PF09976.4 KOO28286.1 - 2.1 8.2 25.6 0.06 13.2 9.8 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat ATG13 PF10033.4 KOO28287.1 - 1.8e-25 89.7 0.0 2.4e-25 89.3 0.0 1.2 1 0 0 1 1 1 1 Autophagy-related protein 13 vATP-synt_AC39 PF01992.11 KOO28288.1 - 2.7e-86 289.7 1.2 3.1e-86 289.5 0.8 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit MORN PF02493.15 KOO28289.1 - 2.6e-28 96.0 18.0 1.5e-07 30.7 0.1 5.5 5 0 0 5 5 5 5 MORN repeat Pkinase PF00069.20 KOO28290.1 - 1.9e-53 181.2 0.0 2.5e-53 180.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.24 KOO28290.1 - 4.7e-39 132.0 0.0 3.1e-23 81.3 0.0 3.3 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.12 KOO28290.1 - 4.1e-26 91.5 0.0 5.9e-26 91.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO28290.1 - 2.2e-07 30.1 0.0 5.3e-07 28.9 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO28290.1 - 5.8e-07 29.4 1.5 0.003 17.3 0.0 3.1 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO28290.1 - 2.9e-06 26.4 0.0 7e-06 25.2 0.0 1.6 1 0 0 1 1 1 1 Kinase-like EF-hand_6 PF13405.1 KOO28290.1 - 1.1e-05 24.8 0.0 6e-05 22.5 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 KOO28290.1 - 9.5e-05 21.4 0.0 0.00042 19.4 0.0 2.2 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO28290.1 - 0.00061 19.8 0.0 0.0024 17.9 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain pair RIO1 PF01163.17 KOO28290.1 - 0.0027 17.0 0.0 0.0072 15.6 0.0 1.5 1 1 1 2 2 2 1 RIO1 family EFhand_Ca_insen PF08726.5 KOO28290.1 - 0.024 14.6 0.1 0.22 11.5 0.0 2.5 2 0 0 2 2 2 0 Ca2+ insensitive EF hand Choline_kinase PF01633.15 KOO28290.1 - 0.05 13.1 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase EF-hand_8 PF13833.1 KOO28290.1 - 0.091 12.3 0.2 0.39 10.3 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.1 KOO28290.1 - 0.17 11.2 0.3 1.1 8.6 0.0 2.5 2 0 0 2 2 2 0 EF hand CdCA1 PF10563.4 KOO28292.1 - 9.6e-77 257.3 1.3 1.4e-76 256.8 0.9 1.2 1 0 0 1 1 1 1 Cadmium carbonic anhydrase repeat EF-hand_1 PF00036.27 KOO28292.1 - 1.2e-11 43.0 0.3 6.7e-05 21.9 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO28292.1 - 4.9e-10 38.8 0.0 0.00014 21.4 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.1 KOO28292.1 - 1.2e-08 34.9 0.0 2.5e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO28292.1 - 1.3e-08 33.9 0.6 0.003 17.3 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO28292.1 - 5.3e-05 22.3 1.0 0.032 13.5 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.2 KOO28292.1 - 0.036 13.8 0.1 8.8 6.1 0.0 2.5 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand CCG PF02754.11 KOO28294.1 - 0.033 14.1 0.2 0.055 13.4 0.1 1.4 1 1 0 1 1 1 0 Cysteine-rich domain Bestrophin PF01062.16 KOO28295.1 - 3.2e-14 52.5 0.2 6.5e-14 51.5 0.1 1.4 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel U-box PF04564.10 KOO28296.1 - 1.5e-10 40.8 0.0 2.9e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 U-box domain SAP PF02037.22 KOO28296.1 - 3.8e-08 32.6 1.0 3.8e-08 32.6 0.7 1.8 2 0 0 2 2 2 1 SAP domain Sel1 PF08238.7 KOO28296.1 - 2.7e-07 31.0 0.8 0.016 15.8 0.0 3.6 3 0 0 3 3 3 2 Sel1 repeat zf-Nse PF11789.3 KOO28296.1 - 0.059 12.9 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit CDC37_C PF08564.5 KOO28296.1 - 7.7 6.4 7.2 0.32 10.8 0.5 2.0 3 0 0 3 3 3 0 Cdc37 C terminal domain Arm PF00514.18 KOO28297.1 - 6.1e-22 76.6 16.7 0.00025 20.7 0.3 6.2 6 0 0 6 6 6 6 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO28297.1 - 6.8e-08 32.6 30.0 0.0035 17.5 3.3 3.5 1 1 1 3 3 3 3 HEAT repeats HEAT PF02985.17 KOO28297.1 - 1.5e-05 24.6 5.2 21 5.5 0.0 6.3 6 0 0 6 6 6 0 HEAT repeat DUF1869 PF08956.5 KOO28297.1 - 0.00013 21.5 1.7 0.36 10.4 0.0 3.7 4 0 0 4 4 4 1 Domain of unknown function (DUF1869) TruB_C PF09142.6 KOO28297.1 - 0.0045 16.5 1.2 0.0045 16.5 0.9 4.9 4 2 2 6 6 6 1 tRNA Pseudouridine synthase II, C terminal Succ_CoA_lig PF13607.1 KOO28297.1 - 0.068 12.7 20.7 0.15 11.6 0.9 3.8 1 1 4 5 5 5 0 Succinyl-CoA ligase like flavodoxin domain Flavodoxin_1 PF00258.20 KOO28297.1 - 0.08 12.9 0.0 0.29 11.1 0.0 1.9 1 1 0 1 1 1 0 Flavodoxin HEAT_EZ PF13513.1 KOO28297.1 - 0.93 10.0 26.2 7.7 7.1 0.2 5.6 3 2 2 5 5 5 0 HEAT-like repeat GST_N_3 PF13417.1 KOO28298.1 - 5.5e-21 74.5 0.0 1.6e-10 41.0 0.0 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 KOO28298.1 - 5e-09 36.0 0.0 0.00027 20.8 0.0 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain PAP_fibrillin PF04755.7 KOO28300.1 - 1.7e-28 99.7 0.0 6.4e-20 71.7 0.0 3.8 2 2 0 2 2 2 2 PAP_fibrillin BAALC_N PF06989.7 KOO28300.1 - 0.21 11.9 0.1 0.21 11.9 0.1 2.9 4 0 0 4 4 4 0 BAALC N-terminus TPR_12 PF13424.1 KOO28301.1 - 5.6e-91 298.5 37.8 6.2e-18 64.5 0.6 7.6 3 1 6 9 9 9 8 Tetratricopeptide repeat TPR_10 PF13374.1 KOO28301.1 - 1e-79 260.4 49.9 6.9e-11 41.7 0.7 9.9 10 0 0 10 10 9 9 Tetratricopeptide repeat TPR_2 PF07719.12 KOO28301.1 - 2.7e-28 95.5 18.5 0.0028 17.4 0.1 9.6 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_1 PF00515.23 KOO28301.1 - 6.9e-27 91.9 8.3 0.011 15.3 0.0 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_7 PF13176.1 KOO28301.1 - 2.1e-26 89.5 27.1 0.0013 18.3 0.2 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_16 PF13432.1 KOO28301.1 - 2.2e-22 79.1 43.4 2.4e-05 24.8 4.3 7.3 2 1 6 8 8 8 8 Tetratricopeptide repeat TPR_11 PF13414.1 KOO28301.1 - 9e-21 73.2 13.1 0.00021 20.8 0.3 6.5 3 2 3 6 6 6 6 TPR repeat TPR_8 PF13181.1 KOO28301.1 - 2.3e-19 67.6 0.5 0.13 12.1 0.0 8.8 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_3 PF07720.7 KOO28301.1 - 2.3e-15 55.9 0.0 1.1 9.1 0.0 8.9 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO28301.1 - 1.8e-14 52.6 15.0 2 8.8 0.0 9.9 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28301.1 - 2e-11 43.4 52.9 0.097 13.3 0.5 10.5 5 3 5 10 10 9 6 Tetratricopeptide repeat TPR_19 PF14559.1 KOO28301.1 - 6e-08 32.9 23.5 0.011 16.0 1.3 6.7 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_4 PF07721.9 KOO28301.1 - 0.00028 21.0 6.7 0.022 15.1 0.2 13.7 16 2 1 17 17 11 4 Tetratricopeptide repeat DUF2379 PF09543.5 KOO28301.1 - 0.00047 20.0 15.1 4.4 7.2 0.0 7.7 8 1 1 9 9 8 1 Protein of unknown function (DUF2379) DUF630 PF04783.7 KOO28301.1 - 0.0034 17.2 20.8 11 5.9 0.0 8.3 9 0 0 9 9 9 0 Protein of unknown function (DUF630) TPR_6 PF13174.1 KOO28301.1 - 0.049 14.1 16.2 46 4.7 0.0 8.4 9 0 0 9 9 8 0 Tetratricopeptide repeat Nucleoplasmin PF03066.10 KOO28301.1 - 0.72 9.3 5.3 1.1 8.7 3.7 1.3 1 0 0 1 1 1 0 Nucleoplasmin NOA36 PF06524.7 KOO28301.1 - 1.9 7.6 8.7 2.7 7.1 6.0 1.2 1 0 0 1 1 1 0 NOA36 protein S-methyl_trans PF02574.11 KOO28302.1 - 1.4e-90 303.6 0.5 3.2e-90 302.5 0.1 1.8 2 0 0 2 2 2 1 Homocysteine S-methyltransferase Met_synt_B12 PF02965.12 KOO28302.1 - 8.1e-73 244.0 0.1 1.5e-72 243.2 0.1 1.5 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain Pterin_bind PF00809.17 KOO28302.1 - 3.5e-37 127.8 0.0 1.4e-36 125.8 0.0 2.2 1 0 0 1 1 1 1 Pterin binding enzyme B12-binding_2 PF02607.12 KOO28302.1 - 7.4e-21 73.9 0.2 5.1e-20 71.2 0.0 2.6 2 0 0 2 2 2 1 B12 binding domain B12-binding PF02310.14 KOO28302.1 - 1.1e-16 60.8 1.5 3.9e-16 59.0 0.1 2.6 3 0 0 3 3 3 1 B12 binding domain TPR_11 PF13414.1 KOO28302.1 - 1.4e-15 56.6 13.8 2e-09 36.9 3.4 4.1 2 1 1 3 3 3 2 TPR repeat TPR_1 PF00515.23 KOO28302.1 - 7.1e-09 34.9 9.2 0.052 13.1 0.4 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO28302.1 - 4e-06 26.3 19.7 0.0013 18.4 0.0 5.2 6 0 0 6 6 4 3 Tetratricopeptide repeat TPR_9 PF13371.1 KOO28302.1 - 0.0002 21.1 4.1 0.00061 19.5 2.8 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOO28302.1 - 0.072 13.0 13.7 0.14 12.0 0.7 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO28302.1 - 0.14 12.6 2.3 0.95 10.0 0.0 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO28302.1 - 0.17 11.7 2.0 10 6.2 0.1 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 KOO28302.1 - 0.17 12.5 8.2 2.7 8.7 0.8 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_60s PF00428.14 KOO28302.1 - 0.29 11.5 16.8 0.016 15.6 5.4 2.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein Thioredoxin PF00085.15 KOO28303.1 - 1.8e-08 34.0 0.2 1.9e-08 33.9 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Rpr2 PF04032.11 KOO28303.1 - 0.0019 18.0 0.8 0.0072 16.1 0.5 1.7 1 1 1 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain DIM1 PF02966.11 KOO28303.1 - 0.013 15.0 0.0 0.015 14.8 0.0 1.1 1 0 0 1 1 1 0 Mitosis protein DIM1 TF_Zn_Ribbon PF08271.7 KOO28303.1 - 0.02 14.2 0.7 0.038 13.3 0.5 1.6 1 1 0 1 1 1 0 TFIIB zinc-binding Thioredoxin_3 PF13192.1 KOO28303.1 - 0.056 13.2 0.2 0.07 12.9 0.1 1.2 1 0 0 1 1 1 0 Thioredoxin domain Thioredoxin_2 PF13098.1 KOO28303.1 - 0.1 12.7 1.2 0.17 12.0 0.8 1.6 1 1 0 1 1 1 0 Thioredoxin-like domain Cyclin_N PF00134.18 KOO28304.1 - 3.5e-10 39.5 0.2 1.5e-09 37.4 0.1 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin PF08613.6 KOO28304.1 - 8.9e-10 39.1 0.3 1.8e-09 38.2 0.2 1.7 1 1 0 1 1 1 1 Cyclin SAM_1 PF00536.25 KOO28304.1 - 2.7e-05 24.2 0.0 4.6e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 KOO28304.1 - 0.00042 20.1 0.0 0.00083 19.1 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) TnpV PF14198.1 KOO28305.1 - 0.53 10.2 4.5 0.85 9.5 0.7 2.2 1 1 1 2 2 2 0 Transposon-encoded protein TnpV Prp19 PF08606.6 KOO28305.1 - 0.58 9.9 0.1 0.58 9.9 0.0 2.8 3 1 0 3 3 3 0 Prp19/Pso4-like ABA_WDS PF02496.11 KOO28305.1 - 1.4 9.1 6.5 0.38 10.9 0.7 2.7 3 0 0 3 3 3 0 ABA/WDS induced protein DUF3180 PF11377.3 KOO28305.1 - 2.2 8.1 5.4 0.36 10.6 0.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3180) Glycos_transf_1 PF00534.15 KOO28306.1 - 2.3e-13 49.9 0.0 5.6e-13 48.6 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 KOO28306.1 - 4.4e-09 36.5 0.0 8e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycogen_syn PF05693.8 KOO28306.1 - 0.0043 15.3 0.0 0.0062 14.8 0.0 1.1 1 0 0 1 1 1 1 Glycogen synthase Glyco_trans_4_4 PF13579.1 KOO28306.1 - 0.0084 16.2 5.3 0.0084 16.2 3.7 3.9 2 2 2 4 4 4 1 Glycosyl transferase 4-like domain LysM PF01476.15 KOO28307.1 - 0.00027 20.7 0.0 0.04 13.8 0.0 2.5 2 1 0 2 2 2 2 LysM domain Terminase_2 PF03592.11 KOO28307.1 - 0.17 12.1 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Terminase small subunit PDZ_2 PF13180.1 KOO28308.1 - 6.8e-07 29.0 1.9 0.083 12.7 0.0 3.4 3 0 0 3 3 3 3 PDZ domain PDZ PF00595.19 KOO28308.1 - 0.0088 16.2 2.3 9.5 6.4 0.0 3.5 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) DUF3420 PF11900.3 KOO28309.1 - 0.015 15.4 0.0 0.063 13.3 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3420) DUF2783 PF10932.3 KOO28309.1 - 0.06 12.8 0.0 0.17 11.3 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2783) APH PF01636.18 KOO28310.1 - 1.1e-06 28.6 0.0 5.4e-06 26.3 0.0 2.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family NACHT PF05729.7 KOO28310.1 - 1.1e-05 25.1 0.0 2.9e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 NACHT domain LRR_6 PF13516.1 KOO28310.1 - 0.00014 21.6 10.4 1.8e+02 2.6 0.0 9.9 11 0 0 11 11 11 0 Leucine Rich repeat LRR_7 PF13504.1 KOO28310.1 - 0.0022 17.8 8.6 2.1e+02 2.8 0.0 8.5 8 0 0 8 8 8 0 Leucine rich repeat Fructosamin_kin PF03881.9 KOO28310.1 - 0.53 9.1 0.0 1.1 8.2 0.0 1.4 1 0 0 1 1 1 0 Fructosamine kinase EcKinase PF02958.15 KOO28310.1 - 0.55 9.3 0.0 0.94 8.5 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase Choline_kinase PF01633.15 KOO28310.1 - 0.63 9.5 0.0 1.1 8.8 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Fn3_assoc PF13287.1 KOO28310.1 - 0.7 10.0 0.0 55 3.9 0.0 2.4 2 0 0 2 2 2 0 Fn3 associated Pkinase PF00069.20 KOO28310.1 - 0.92 8.5 0.0 1.6 7.7 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain Topoisom_bac PF01131.15 KOO28311.1 - 6e-20 71.4 0.0 6.5e-19 68.0 0.0 2.0 2 0 0 2 2 2 1 DNA topoisomerase Toprim PF01751.17 KOO28311.1 - 5e-15 55.2 0.0 8e-15 54.6 0.0 1.3 1 0 0 1 1 1 1 Toprim domain Tub PF01167.13 KOO28313.1 - 1.7e-20 73.0 0.0 1.4e-19 70.0 0.0 2.1 1 1 0 1 1 1 1 Tub family Bromodomain PF00439.20 KOO28314.1 - 4.2e-24 84.2 0.0 9.8e-24 83.0 0.0 1.6 1 0 0 1 1 1 1 Bromodomain AAA_23 PF13476.1 KOO28314.1 - 1.4 9.2 4.4 1.8 8.8 0.9 2.1 2 0 0 2 2 2 0 AAA domain DUF1266 PF06889.6 KOO28314.1 - 1.7 8.3 11.6 0.66 9.7 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1266) Methyltransf_23 PF13489.1 KOO28315.1 - 5.5e-17 61.9 0.0 1.2e-16 60.8 0.0 1.5 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO28315.1 - 4.1e-14 52.8 0.0 6.5e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO28315.1 - 2.4e-13 49.9 0.0 2.8e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO28315.1 - 1.6e-12 47.7 0.0 4e-12 46.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO28315.1 - 5.4e-11 43.0 0.0 1.8e-10 41.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO28315.1 - 1.8e-09 37.8 0.0 3.4e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO28315.1 - 2.1e-08 34.1 0.6 6.6e-08 32.5 0.4 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO28315.1 - 1e-05 24.7 0.0 1.3e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.9 KOO28315.1 - 1.8e-05 24.2 0.0 3e-05 23.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.1 KOO28315.1 - 0.0012 18.5 0.0 0.0017 18.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain FmrO PF07091.6 KOO28315.1 - 0.0055 15.7 0.0 0.008 15.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA methyltransferase (FmrO) FtsJ PF01728.14 KOO28315.1 - 0.025 14.5 0.0 0.037 14.0 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_8 PF05148.10 KOO28315.1 - 0.04 13.5 0.0 0.1 12.1 0.0 1.6 1 1 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_16 PF10294.4 KOO28315.1 - 0.072 12.5 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase PrmA PF06325.8 KOO28315.1 - 0.076 12.1 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.14 KOO28315.1 - 0.087 12.3 0.0 0.12 11.9 0.0 1.4 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Exostosin PF03016.10 KOO28316.1 - 1e-13 51.0 0.0 1.3e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 Exostosin family SHIPPO-rpt PF07004.7 KOO28317.1 - 6.8e-16 58.2 32.0 0.056 14.3 0.0 10.3 10 0 0 10 10 10 7 Sperm-tail PG-rich repeat DUF2403 PF10290.4 KOO28317.1 - 0.11 12.6 0.2 29 4.9 0.0 2.7 2 0 0 2 2 2 0 Glycine-rich protein domain (DUF2403) SMK-1 PF04802.10 KOO28317.1 - 0.16 11.4 0.0 17 4.8 0.0 2.1 2 0 0 2 2 2 0 Component of IIS longevity pathway SMK-1 Ank_2 PF12796.2 KOO28318.1 - 1.8e-22 79.4 6.6 1.9e-11 44.1 0.9 2.8 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO28318.1 - 1.7e-17 62.2 6.6 4.3e-05 23.1 0.0 5.0 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.1 KOO28318.1 - 6.6e-15 54.8 9.2 3.9e-07 30.1 0.3 5.5 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO28318.1 - 1.6e-12 47.5 0.8 3.6e-06 27.3 0.2 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO28318.1 - 2.4e-12 45.8 3.2 0.01 15.9 0.0 5.6 6 0 0 6 6 6 4 Ankyrin repeat NACHT PF05729.7 KOO28318.1 - 3.9e-05 23.3 0.0 0.00022 20.9 0.0 2.4 3 1 0 3 3 3 1 NACHT domain AAA_25 PF13481.1 KOO28318.1 - 0.00074 18.9 0.4 0.0054 16.1 0.1 2.6 2 0 0 2 2 2 1 AAA domain NT5C PF06941.7 KOO28319.1 - 1.3e-26 93.3 0.0 2.4e-26 92.4 0.0 1.4 1 0 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Laminin_G_3 PF13385.1 KOO28319.1 - 2.8e-07 30.9 0.0 1.2e-06 28.8 0.0 1.9 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Ank_2 PF12796.2 KOO28321.1 - 1.1e-71 237.2 39.1 3e-16 59.5 0.1 6.7 3 1 5 8 8 8 7 Ankyrin repeats (3 copies) Ank PF00023.25 KOO28321.1 - 3.5e-53 174.8 43.7 1.5e-06 27.6 0.5 12.6 12 0 0 12 12 12 11 Ankyrin repeat Ank_4 PF13637.1 KOO28321.1 - 3.3e-38 129.3 15.4 2.3e-08 34.3 0.0 8.9 4 2 5 10 10 10 8 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO28321.1 - 1.8e-35 120.1 32.6 5.9e-06 26.3 0.1 10.3 4 1 7 11 11 11 9 Ankyrin repeats (many copies) Pro_isomerase PF00160.16 KOO28321.1 - 3.2e-35 121.6 0.0 5.1e-35 120.9 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ank_3 PF13606.1 KOO28321.1 - 1.1e-27 93.3 24.2 0.01 15.9 0.0 12.2 12 0 0 12 12 12 7 Ankyrin repeat TPR_11 PF13414.1 KOO28321.1 - 6.1e-06 25.7 13.9 0.00099 18.7 1.9 3.3 2 1 1 3 3 3 2 TPR repeat TPR_9 PF13371.1 KOO28321.1 - 7.7e-05 22.4 2.1 7.7e-05 22.4 1.4 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO28321.1 - 0.0014 18.1 1.3 0.021 14.4 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO28321.1 - 0.0073 16.1 5.3 0.19 11.7 0.2 3.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOO28322.1 - 2.2e-61 203.4 29.8 2.4e-18 65.5 0.6 6.2 6 0 0 6 6 6 6 TPR repeat TPR_1 PF00515.23 KOO28322.1 - 4.7e-48 158.9 23.7 1.9e-06 27.2 0.1 9.4 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.12 KOO28322.1 - 2.5e-40 133.1 25.4 6.6e-05 22.5 1.1 9.5 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_12 PF13424.1 KOO28322.1 - 1.5e-23 82.4 22.5 4.9e-10 39.1 0.1 7.2 2 2 4 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.1 KOO28322.1 - 3.9e-20 71.9 20.9 1.6e-05 25.3 0.3 6.9 6 1 1 7 7 6 4 Tetratricopeptide repeat TPR_8 PF13181.1 KOO28322.1 - 4.6e-16 57.3 16.6 0.0081 15.8 0.0 9.2 8 1 1 9 9 9 5 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28322.1 - 6.4e-16 57.4 12.4 0.21 12.3 0.1 8.1 6 2 2 8 8 7 5 Tetratricopeptide repeat TPR_7 PF13176.1 KOO28322.1 - 1.2e-13 49.7 14.6 0.06 13.1 0.0 8.4 8 1 1 9 9 9 4 Tetratricopeptide repeat TPR_9 PF13371.1 KOO28322.1 - 4.1e-09 36.1 5.6 0.037 13.8 0.0 6.5 3 2 4 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO28322.1 - 1.5e-08 34.1 10.8 0.011 15.8 0.0 7.8 8 1 1 9 9 8 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO28322.1 - 9.1e-08 32.3 23.5 0.24 11.7 0.0 7.1 5 1 2 7 7 7 3 Tetratricopeptide repeat Apc3 PF12895.2 KOO28322.1 - 1.7e-06 28.0 20.0 0.016 15.2 3.7 5.7 3 2 2 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.1 KOO28322.1 - 1.7e-05 24.6 0.0 0.027 14.3 0.0 4.5 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.1 KOO28322.1 - 2e-05 24.7 23.8 2.8 8.5 0.1 9.2 9 0 0 9 9 9 1 Tetratricopeptide repeat SHNi-TPR PF10516.4 KOO28322.1 - 0.00091 18.4 0.0 10 5.4 0.0 4.6 4 0 0 4 4 4 0 SHNi-TPR Sugarporin_N PF11471.3 KOO28322.1 - 0.0011 18.5 2.9 0.26 10.9 0.0 2.8 2 0 0 2 2 2 1 Maltoporin periplasmic N-terminal extension RPN7 PF10602.4 KOO28322.1 - 0.0036 16.6 1.7 0.0036 16.6 1.2 4.0 3 2 2 5 5 4 1 26S proteasome subunit RPN7 MIT PF04212.13 KOO28322.1 - 0.017 14.9 27.2 0.14 12.0 0.2 6.7 5 2 2 7 7 7 0 MIT (microtubule interacting and transport) domain Syntaxin PF00804.20 KOO28322.1 - 0.024 14.8 0.7 0.14 12.3 0.2 2.4 2 0 0 2 2 2 0 Syntaxin Lebercilin PF15619.1 KOO28322.1 - 0.025 14.0 6.5 0.074 12.4 4.5 1.8 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease BTAD PF03704.12 KOO28322.1 - 0.04 14.2 10.7 7.6 6.8 0.0 4.8 2 2 2 4 4 4 0 Bacterial transcriptional activator domain TPR_10 PF13374.1 KOO28322.1 - 0.043 13.7 9.4 36 4.4 0.1 6.7 6 1 1 7 7 7 0 Tetratricopeptide repeat Syntaxin-6_N PF09177.6 KOO28322.1 - 0.07 13.5 0.9 0.22 11.9 0.1 2.2 2 0 0 2 2 2 0 Syntaxin 6, N-terminal TPM PF04536.9 KOO28322.1 - 0.088 12.6 3.8 18 5.2 0.0 3.7 3 0 0 3 3 3 0 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase RNase_T PF00929.19 KOO28322.1 - 1.9 8.7 5.7 17 5.6 1.8 2.6 1 1 1 2 2 2 0 Exonuclease Strep_SA_rep PF06696.6 KOO28322.1 - 3.4 7.5 10.4 0.3 10.9 0.2 4.3 4 0 0 4 4 4 0 Streptococcal surface antigen repeat Glyoxalase_2 PF12681.2 KOO28323.1 - 0.0036 17.8 0.0 0.0062 17.1 0.0 1.4 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.1 KOO28323.1 - 0.0082 16.1 0.0 0.66 10.0 0.0 2.3 1 1 1 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily TIL PF01826.12 KOO28324.1 - 0.021 14.9 6.1 0.038 14.1 4.2 1.4 1 0 0 1 1 1 0 Trypsin Inhibitor like cysteine rich domain Pkinase PF00069.20 KOO28325.1 - 2.2e-46 158.1 0.0 4.4e-34 117.7 0.1 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO28325.1 - 6.6e-19 67.9 0.2 8.6e-18 64.3 0.1 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 KOO28325.1 - 2.2e-09 36.7 0.1 1.7e-07 30.4 0.0 2.3 1 1 1 2 2 2 2 Kinase-like APH PF01636.18 KOO28325.1 - 0.011 15.4 0.2 0.055 13.1 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 KOO28325.1 - 0.043 12.8 0.1 0.091 11.8 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PPR_2 PF13041.1 KOO28327.1 - 1.5e-29 101.7 0.0 1.9e-08 34.1 0.0 6.3 4 2 2 6 6 6 5 PPR repeat family PPR PF01535.15 KOO28327.1 - 1.1e-23 81.4 0.9 0.0011 18.7 0.0 9.3 10 0 0 10 10 10 6 PPR repeat PPR_3 PF13812.1 KOO28327.1 - 2e-20 71.3 16.3 4.8e-07 29.5 0.1 10.1 10 0 0 10 10 10 5 Pentatricopeptide repeat domain PPR_1 PF12854.2 KOO28327.1 - 7.3e-18 63.7 0.4 0.00059 19.2 0.0 7.5 8 0 0 8 8 8 4 PPR repeat TPR_19 PF14559.1 KOO28327.1 - 1.6e-05 25.1 4.3 2.5 8.4 0.0 5.5 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28327.1 - 1.6e-05 25.0 34.8 0.042 14.4 0.0 9.4 5 2 5 10 10 10 4 Tetratricopeptide repeat TPR_7 PF13176.1 KOO28327.1 - 0.00035 20.1 1.0 4.8 7.2 0.0 5.1 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOO28327.1 - 0.00061 19.6 11.7 0.021 14.7 0.6 4.6 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO28327.1 - 0.0025 17.6 3.1 1.1 9.3 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO28327.1 - 0.013 16.1 2.5 0.023 15.3 2.1 6.3 5 2 2 7 7 7 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOO28327.1 - 0.25 11.0 2.1 2.1 8.0 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Mito_carr PF00153.22 KOO28328.1 - 8.8e-65 214.4 2.5 6.6e-21 73.8 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein GP41 PF00517.12 KOO28329.1 - 0.084 12.4 0.9 0.24 10.9 0.1 1.9 2 0 0 2 2 2 0 Retroviral envelope protein SpoIID PF08486.5 KOO28330.1 - 0.071 13.3 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Stage II sporulation protein DUF3783 PF12646.2 KOO28333.1 - 0.093 12.4 0.0 8.6 6.1 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3783) DUF3727 PF12527.3 KOO28334.1 - 5.5e-10 39.2 7.1 5.5e-10 39.2 5.0 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF3727) AAA_23 PF13476.1 KOO28335.1 - 9.8e-05 22.7 0.3 0.00033 21.0 0.2 2.1 1 1 0 1 1 1 1 AAA domain IRK PF01007.15 KOO28335.1 - 0.00053 18.8 3.4 0.0014 17.5 2.4 1.6 1 1 0 1 1 1 1 Inward rectifier potassium channel Ion_trans_2 PF07885.11 KOO28335.1 - 0.0029 17.2 11.9 0.0069 16.0 8.2 1.6 1 0 0 1 1 1 1 Ion channel Metallophos_2 PF12850.2 KOO28335.1 - 0.0034 17.2 0.0 0.0074 16.1 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 KOO28335.1 - 0.059 12.7 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase Lig_chan PF00060.21 KOO28335.1 - 3.9 7.1 4.5 7.5 6.2 3.1 1.4 1 0 0 1 1 1 0 Ligand-gated ion channel Ricin_B_lectin PF00652.17 KOO28336.1 - 0.00011 22.2 0.0 0.019 14.9 0.0 2.7 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain CDtoxinA PF03498.9 KOO28336.1 - 0.01 15.2 0.0 0.13 11.5 0.0 2.5 3 0 0 3 3 3 0 Cytolethal distending toxin A/C family SHIPPO-rpt PF07004.7 KOO28337.1 - 0.0058 17.4 3.0 1.7 9.6 1.2 2.5 2 1 0 2 2 2 2 Sperm-tail PG-rich repeat Pkinase PF00069.20 KOO28340.1 - 7.8e-13 48.1 0.0 8.5e-13 48.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO28340.1 - 5.6e-06 25.6 0.0 6.1e-06 25.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 KOO28341.1 - 2.2e-54 184.3 0.0 2.7e-54 184.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO28341.1 - 3e-21 75.6 0.0 4e-21 75.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO28341.1 - 0.0044 16.7 0.0 0.0079 15.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO28341.1 - 0.011 14.7 0.0 0.015 14.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Phenol_Hydrox PF02332.13 KOO28341.1 - 0.098 11.9 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Methane/Phenol/Toluene Hydroxylase Choline_kinase PF01633.15 KOO28341.1 - 0.13 11.8 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF2475 PF10629.4 KOO28342.1 - 3.5e-13 49.5 10.7 0.0082 16.3 0.2 4.6 4 0 0 4 4 4 4 Protein of unknown function (DUF2475) Pax2_C PF12403.3 KOO28342.1 - 0.0072 15.9 8.1 17 5.0 0.2 4.3 4 0 0 4 4 4 4 Paired-box protein 2 C terminal NAGLU PF05089.7 KOO28342.1 - 0.0079 14.9 1.1 1.9 7.1 0.0 3.8 4 1 0 4 4 4 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain PP2C PF00481.16 KOO28343.1 - 5.1e-23 81.7 0.0 6.4e-23 81.4 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 KOO28343.1 - 2.2e-08 33.7 0.1 4.9e-08 32.6 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOO28343.1 - 0.00074 19.2 0.1 0.0031 17.2 0.1 1.9 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) SAP PF02037.22 KOO28344.1 - 1.1e-05 24.7 1.0 2e-05 23.9 0.7 1.4 1 0 0 1 1 1 1 SAP domain Telomere_Sde2_2 PF13297.1 KOO28344.1 - 0.076 12.2 0.8 0.17 11.1 0.5 1.6 1 0 0 1 1 1 0 Telomere stability C-terminal Methyltransf_23 PF13489.1 KOO28344.1 - 0.099 12.3 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Ank_2 PF12796.2 KOO28345.1 - 1e-25 89.9 0.1 3.3e-13 49.7 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO28345.1 - 2.8e-17 61.5 0.3 1.2e-10 40.6 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 KOO28345.1 - 2.1e-12 46.8 2.4 6.8e-09 35.6 0.2 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO28345.1 - 9.6e-12 43.9 0.1 4.3e-06 26.4 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat ADPrib_exo_Tox PF03496.9 KOO28345.1 - 8.4e-11 41.4 0.0 2.2e-10 40.0 0.0 1.7 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Ank_4 PF13637.1 KOO28345.1 - 7.7e-10 39.0 0.8 4.2e-05 23.9 0.0 3.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) ART PF01129.13 KOO28345.1 - 9.3e-10 37.9 0.0 2.9e-09 36.3 0.0 1.8 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase IQ PF00612.22 KOO28345.1 - 0.34 10.6 0.0 0.34 10.6 0.0 2.9 3 0 0 3 3 3 0 IQ calmodulin-binding motif DUF4476 PF14771.1 KOO28346.1 - 7e-22 77.2 0.6 1.7e-15 56.7 0.0 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4476) VWA_2 PF13519.1 KOO28346.1 - 1.5e-14 54.5 0.5 1.5e-14 54.5 0.3 2.1 2 1 0 2 2 2 1 von Willebrand factor type A domain VWA_3 PF13768.1 KOO28346.1 - 3.5e-11 43.0 0.5 4.3e-10 39.5 0.0 2.7 2 2 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.23 KOO28346.1 - 0.013 15.2 0.0 0.03 14.0 0.0 1.7 1 0 0 1 1 1 0 von Willebrand factor type A domain Amino_oxidase PF01593.19 KOO28349.1 - 2.7e-60 204.7 0.0 3.1e-60 204.5 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 KOO28349.1 - 3.1e-15 55.9 0.2 7.9e-15 54.6 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 KOO28349.1 - 8.7e-10 38.0 0.1 5.8e-05 22.1 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 KOO28349.1 - 1.4e-05 24.1 0.0 0.0018 17.2 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.22 KOO28349.1 - 3.3e-05 24.2 0.1 0.027 14.8 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 KOO28349.1 - 0.0002 21.3 0.0 0.00083 19.2 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 KOO28349.1 - 0.00034 19.1 0.6 0.0015 17.0 0.4 1.8 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.1 KOO28349.1 - 0.0007 19.7 0.5 0.0022 18.0 0.3 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 KOO28349.1 - 0.00078 18.6 0.1 0.0015 17.6 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.17 KOO28349.1 - 0.0019 17.1 0.1 0.0035 16.2 0.1 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_3 PF01494.14 KOO28349.1 - 0.0077 15.3 0.1 0.037 13.0 0.1 1.9 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.12 KOO28349.1 - 0.017 14.2 1.6 0.027 13.5 0.2 1.8 2 0 0 2 2 2 0 Thi4 family AlaDh_PNT_C PF01262.16 KOO28349.1 - 0.032 13.7 0.2 0.083 12.4 0.1 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.13 KOO28349.1 - 0.046 13.3 0.1 0.078 12.6 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Rossmann-like PF10727.4 KOO28349.1 - 0.063 12.9 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 Rossmann-like domain Strep_67kDa_ant PF06100.6 KOO28349.1 - 0.096 11.0 0.1 4.2 5.6 0.0 2.1 2 0 0 2 2 2 0 Streptococcal 67 kDa myosin-cross-reactive antigen like family PKD_channel PF08016.7 KOO28350.1 - 5.2e-29 100.9 10.5 5.2e-29 100.9 7.3 2.1 2 1 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.26 KOO28350.1 - 3.3e-11 42.8 16.6 3.3e-11 42.8 11.5 1.6 2 0 0 2 2 2 1 Ion transport protein NAD_binding_10 PF13460.1 KOO28352.1 - 1.1e-16 61.3 0.3 1.6e-16 60.8 0.2 1.3 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 KOO28352.1 - 7.5e-09 35.3 0.1 1.5e-08 34.3 0.1 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 KOO28352.1 - 1.3e-08 34.3 0.0 2.1e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.14 KOO28352.1 - 7.6e-07 28.1 0.1 1.7e-05 23.6 0.0 2.2 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 KOO28352.1 - 0.0045 16.9 3.4 0.0081 16.0 0.6 2.7 2 1 0 2 2 2 1 short chain dehydrogenase ELFV_dehydrog PF00208.16 KOO28352.1 - 0.044 13.3 0.0 0.086 12.4 0.0 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NAD_binding_7 PF13241.1 KOO28352.1 - 0.062 13.5 0.1 0.1 12.8 0.1 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding RmlD_sub_bind PF04321.12 KOO28352.1 - 0.082 11.7 0.1 0.95 8.2 0.1 2.2 1 1 0 1 1 1 0 RmlD substrate binding domain NAD_binding_4 PF07993.7 KOO28352.1 - 0.084 11.7 0.0 6.6 5.5 0.0 2.3 2 1 0 2 2 2 0 Male sterility protein ParcG PF10274.4 KOO28353.1 - 2.8e-83 278.3 0.0 3.6e-83 277.9 0.0 1.1 1 0 0 1 1 1 1 Parkin co-regulated protein DUF2475 PF10629.4 KOO28354.1 - 2.1e-05 24.6 1.2 0.1 12.8 0.2 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF2475) Pkinase PF00069.20 KOO28355.1 - 7.3e-42 143.3 0.0 8.2e-42 143.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO28355.1 - 2.3e-25 89.1 0.0 2.6e-25 88.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO28355.1 - 7.8e-05 21.8 0.0 0.00026 20.1 0.0 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO28355.1 - 0.00044 20.0 2.8 0.034 13.8 0.6 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family SBBP PF06739.6 KOO28356.1 - 0.00017 21.3 8.0 0.6 9.9 0.4 4.0 4 0 0 4 4 4 3 Beta-propeller repeat HMG_box PF00505.14 KOO28357.1 - 1.8e-14 53.7 11.5 2.2e-08 34.2 1.6 2.8 3 0 0 3 3 3 2 HMG (high mobility group) box FHA PF00498.21 KOO28357.1 - 4.7e-14 52.2 0.0 1.4e-13 50.7 0.0 1.8 2 0 0 2 2 2 1 FHA domain APH PF01636.18 KOO28357.1 - 1.7e-08 34.5 1.5 1.7e-08 34.4 0.1 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.15 KOO28357.1 - 3.5e-08 32.9 0.0 5.1e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase HMG_box_2 PF09011.5 KOO28357.1 - 7.7e-06 26.1 13.4 0.003 17.9 2.0 2.5 1 1 1 2 2 2 2 HMG-box domain HMG_box_5 PF14887.1 KOO28357.1 - 0.00035 20.2 9.1 0.072 12.8 1.4 2.5 2 0 0 2 2 2 2 HMG (high mobility group) box 5 DUF1679 PF07914.6 KOO28357.1 - 0.011 14.4 0.0 0.017 13.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Choline_kinase PF01633.15 KOO28357.1 - 0.092 12.3 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF1289 PF06945.8 KOO28357.1 - 1.1 8.7 3.8 22 4.6 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1289) Apolipoprotein PF01442.13 KOO28358.1 - 0.023 14.2 3.8 0.034 13.6 2.6 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain GTPase_Cys_C PF12631.2 KOO28358.1 - 0.63 10.4 3.4 3.3 8.1 2.0 2.5 1 1 1 2 2 2 0 Catalytic cysteine-containing C-terminus of GTPase, MnmE Nucleotid_trans PF03407.11 KOO28359.1 - 1.1e-06 28.6 0.0 1.5e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Cupin_8 PF13621.1 KOO28360.1 - 2.6e-18 66.4 0.0 1.5e-17 63.9 0.0 2.0 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.17 KOO28360.1 - 3.4e-16 59.5 0.0 2.3e-15 56.8 0.0 2.1 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_4 PF08007.7 KOO28360.1 - 8e-06 25.3 0.0 1.1e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Cupin superfamily protein MAPEG PF01124.13 KOO28361.1 - 6.9e-16 58.0 1.8 6.9e-16 58.0 1.2 1.8 2 0 0 2 2 2 1 MAPEG family Methyltransf_23 PF13489.1 KOO28361.1 - 1.6e-08 34.4 0.0 2.4e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO28361.1 - 0.00021 21.6 0.0 0.00053 20.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO28361.1 - 0.00045 19.8 0.0 0.0008 19.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO28361.1 - 0.00052 20.4 0.0 0.0011 19.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO28361.1 - 0.045 14.3 0.0 0.17 12.4 0.0 2.1 2 1 0 2 2 2 0 Methyltransferase domain EF-hand_1 PF00036.27 KOO28362.1 - 2.1e-21 73.4 0.5 0.00016 20.7 0.0 4.7 5 0 0 5 5 5 4 EF hand EF-hand_5 PF13202.1 KOO28362.1 - 5.3e-19 66.6 1.5 0.0022 17.2 0.0 4.7 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.1 KOO28362.1 - 1.8e-16 59.9 5.0 2.7e-08 33.8 0.1 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO28362.1 - 2.8e-16 57.8 1.7 0.0058 16.4 0.0 4.8 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.1 KOO28362.1 - 5.8e-14 51.4 15.3 0.00021 20.8 0.3 4.4 3 2 2 5 5 5 4 EF-hand domain pair EF-hand_4 PF12763.2 KOO28362.1 - 6.9e-10 38.6 5.9 0.0033 17.1 0.1 4.0 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand nec1 PF10379.4 KOO28362.1 - 0.013 14.8 0.1 4 6.6 0.0 2.2 1 1 0 2 2 2 0 Virulence protein nec1 EF-hand_10 PF14788.1 KOO28362.1 - 0.019 14.6 1.3 13 5.5 0.0 3.6 4 0 0 4 4 4 0 EF hand EF-hand_9 PF14658.1 KOO28362.1 - 0.08 12.8 0.1 11 6.0 0.0 3.3 2 1 0 3 3 3 0 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO28362.1 - 0.13 12.2 1.7 24 4.9 0.1 3.5 3 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Excalibur PF05901.6 KOO28362.1 - 0.39 11.0 4.1 14 6.1 0.1 2.7 2 1 0 2 2 2 0 Excalibur calcium-binding domain VCBS PF13517.1 KOO28362.1 - 7.8 6.9 9.2 18 5.8 0.0 3.2 3 1 1 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Agenet PF05641.7 KOO28363.1 - 1.1e-14 54.3 4.2 1.4e-07 31.5 0.1 4.3 3 1 1 4 4 4 3 Agenet domain PP2C PF00481.16 KOO28364.1 - 1.3e-28 100.0 0.0 1.9e-28 99.5 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOO28364.1 - 1.6e-09 37.7 0.4 5.7e-08 32.6 0.3 2.2 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 KOO28364.1 - 2.3e-06 27.1 0.0 6.1e-06 25.7 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C EF-hand_1 PF00036.27 KOO28365.1 - 3.9e-08 32.0 0.1 0.00058 18.9 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO28365.1 - 1.6e-07 30.3 1.4 5.3e-05 22.3 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO28365.1 - 3.3e-07 29.6 0.2 0.0021 17.7 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO28365.1 - 1.1e-05 24.9 0.1 0.0062 16.1 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.1 KOO28365.1 - 1.5e-05 25.0 0.1 0.042 13.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair DUF1079 PF06435.6 KOO28365.1 - 0.15 12.0 0.2 0.51 10.3 0.0 1.9 2 1 1 3 3 3 0 Repeat of unknown function (DUF1079) Syja_N PF02383.13 KOO28366.1 - 3.6e-46 157.3 0.0 5e-46 156.9 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.18 KOO28366.1 - 1.3e-24 87.4 0.0 2.1e-24 86.8 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Lipase_GDSL_2 PF13472.1 KOO28367.1 - 6.9e-10 39.3 0.0 1.6e-09 38.1 0.0 1.6 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family UFD1 PF03152.9 KOO28368.1 - 7.6e-14 51.2 0.0 1e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 TPR_11 PF13414.1 KOO28369.1 - 1.2e-26 92.0 8.0 1.8e-09 37.0 0.1 4.9 3 2 2 5 5 5 4 TPR repeat TPR_2 PF07719.12 KOO28369.1 - 1.3e-18 65.3 17.2 0.00037 20.1 0.6 7.9 8 1 0 8 8 8 6 Tetratricopeptide repeat TPR_16 PF13432.1 KOO28369.1 - 3.8e-15 56.1 39.3 3.1e-07 30.8 4.4 5.4 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO28369.1 - 7.8e-14 50.6 2.3 0.00016 21.1 0.1 6.7 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOO28369.1 - 1.5e-10 40.8 13.9 5.7e-05 22.9 0.7 4.7 2 2 3 5 5 5 5 Tetratricopeptide repeat TPR_19 PF14559.1 KOO28369.1 - 1e-09 38.5 16.4 0.00022 21.5 0.9 5.4 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO28369.1 - 1.3e-08 34.3 2.0 0.0015 18.5 0.1 5.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOO28369.1 - 1.2e-07 31.4 25.5 1e-05 25.3 2.6 5.0 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.1 KOO28369.1 - 1.3e-07 31.5 3.0 1.5 9.4 0.0 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO28369.1 - 2.3e-07 30.1 0.0 0.27 11.0 0.0 5.2 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28369.1 - 3.4e-07 30.2 36.4 0.00012 22.3 1.3 7.5 4 2 4 8 8 7 4 Tetratricopeptide repeat Apc3 PF12895.2 KOO28369.1 - 7.9e-06 25.9 2.8 0.03 14.4 0.5 3.7 3 2 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 KOO28369.1 - 1.1e-05 24.7 7.3 0.005 16.5 0.1 5.0 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_4 PF07721.9 KOO28369.1 - 0.011 16.0 26.6 0.95 10.0 0.3 6.9 6 0 0 6 6 6 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO28369.1 - 0.013 15.3 2.7 0.95 9.3 0.4 3.5 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat BTAD PF03704.12 KOO28369.1 - 0.11 12.7 22.9 0.15 12.3 7.5 2.7 2 1 0 2 2 2 0 Bacterial transcriptional activator domain TPR_10 PF13374.1 KOO28369.1 - 5.8 6.9 15.1 0.52 10.3 0.7 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat PDZ PF00595.19 KOO28370.1 - 8.7e-08 32.2 0.1 1.3e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO28370.1 - 0.00066 19.5 0.1 0.001 18.9 0.1 1.3 1 0 0 1 1 1 1 PDZ domain AA_permease_2 PF13520.1 KOO28371.1 - 8e-07 27.9 10.4 8.8e-07 27.8 7.2 1.0 1 0 0 1 1 1 1 Amino acid permease SHIPPO-rpt PF07004.7 KOO28372.1 - 0.041 14.7 11.5 1.8 9.5 0.6 4.1 3 0 0 3 3 3 0 Sperm-tail PG-rich repeat Bacillus_PapR PF05968.6 KOO28373.1 - 0.018 15.1 0.0 0.032 14.2 0.0 1.3 1 0 0 1 1 1 0 Bacillus PapR protein DUF4407 PF14362.1 KOO28373.1 - 0.025 13.5 2.0 0.029 13.3 1.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4164 PF13747.1 KOO28373.1 - 0.037 14.1 0.8 0.077 13.1 0.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) AAA_13 PF13166.1 KOO28373.1 - 0.056 11.9 0.3 0.067 11.6 0.2 1.1 1 0 0 1 1 1 0 AAA domain CIA30 PF08547.7 KOO28374.1 - 4.4e-05 23.4 0.0 7.9e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) Peptidase_C69 PF03577.10 KOO28375.1 - 2.4e-55 188.0 0.0 1.8e-54 185.1 0.0 1.9 1 1 0 1 1 1 1 Peptidase family C69 ABC1 PF03109.11 KOO28376.1 - 8.7e-27 93.4 0.0 1.5e-26 92.6 0.0 1.4 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 KOO28376.1 - 6e-06 26.1 1.2 6e-06 26.1 0.8 3.3 2 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.20 KOO28376.1 - 0.0055 15.8 0.0 1.6 7.8 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain DnaG_DnaB_bind PF08278.6 KOO28377.1 - 0.14 12.4 0.6 0.14 12.4 0.4 1.5 2 0 0 2 2 2 0 DNA primase DnaG DnaB-binding Na_H_Exchanger PF00999.16 KOO28378.1 - 0.28 9.6 17.3 0.023 13.2 6.6 2.5 2 2 1 3 3 3 0 Sodium/hydrogen exchanger family Gtr1_RagA PF04670.7 KOO28379.1 - 4.7e-68 228.8 1.7 5.8e-68 228.5 1.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 KOO28379.1 - 2.5e-06 26.8 0.0 4e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.16 KOO28379.1 - 8.7e-05 21.8 0.0 0.00013 21.2 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 KOO28379.1 - 0.00024 20.5 0.2 0.00036 20.0 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Miro PF08477.8 KOO28379.1 - 0.0013 19.1 0.0 0.0026 18.2 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 KOO28379.1 - 0.002 18.0 0.0 0.0048 16.8 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.17 KOO28379.1 - 0.01 15.2 0.1 0.015 14.6 0.1 1.3 1 0 0 1 1 1 0 Ras family DUF815 PF05673.8 KOO28379.1 - 0.015 14.2 0.0 0.027 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_14 PF13173.1 KOO28379.1 - 0.016 15.0 0.0 0.033 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 KOO28379.1 - 0.087 12.8 0.2 1.1 9.2 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain Chorein_N PF12624.2 KOO28380.1 - 3.8e-29 100.6 0.0 7.3e-29 99.7 0.0 1.4 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter DUF1289 PF06945.8 KOO28380.1 - 0.35 10.3 2.7 0.35 10.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1289) DUF1162 PF06650.7 KOO28381.1 - 4.8e-32 111.2 0.0 3.8e-15 55.8 0.0 3.3 3 0 0 3 3 3 3 Protein of unknown function (DUF1162) GRAM PF02893.15 KOO28381.1 - 7.9e-12 44.5 0.0 6.9e-05 22.2 0.0 2.4 2 0 0 2 2 2 2 GRAM domain ATG_C PF09333.6 KOO28381.1 - 1.6e-06 28.1 0.0 6e-06 26.3 0.0 2.0 1 0 0 1 1 1 1 ATG C terminal domain Vps36_ESCRT-II PF11605.3 KOO28381.1 - 0.0067 16.2 0.1 0.48 10.2 0.0 3.2 3 0 0 3 3 3 1 Vacuolar protein sorting protein 36 Vps36 RCC1_2 PF13540.1 KOO28383.1 - 1e-13 50.4 0.6 2.3e-06 27.0 0.1 2.5 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.13 KOO28383.1 - 5.7e-09 36.0 0.3 2.9e-06 27.3 0.2 2.9 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat PAF-AH_p_II PF03403.8 KOO28384.1 - 8.5e-10 37.4 0.0 3.3e-05 22.3 0.0 2.7 1 1 1 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_6 PF12697.2 KOO28384.1 - 1.5e-06 28.3 3.2 7.5e-06 25.9 1.0 2.2 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO28384.1 - 2.3e-06 27.4 0.1 3.7e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 KOO28384.1 - 0.00092 18.8 0.1 0.0017 17.9 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.15 KOO28384.1 - 0.00095 18.7 0.0 0.0017 17.9 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Aldo_ket_red PF00248.16 KOO28388.1 - 1.9e-48 164.7 0.0 2.7e-48 164.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Cupin_8 PF13621.1 KOO28388.1 - 1.8e-31 109.5 0.0 3.1e-31 108.7 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 KOO28388.1 - 6e-06 25.7 0.0 2.4e-05 23.7 0.0 2.0 2 0 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.17 KOO28388.1 - 0.011 15.9 0.0 0.023 14.9 0.0 1.5 1 0 0 1 1 1 0 JmjC domain, hydroxylase HECT PF00632.20 KOO28390.1 - 8e-54 182.9 0.0 9.4e-54 182.6 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Laminin_G_3 PF13385.1 KOO28391.1 - 0.0044 17.2 0.0 0.062 13.5 0.0 2.5 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily DUF3638 PF12340.3 KOO28392.1 - 6.5e-16 58.0 0.1 4.4e-15 55.2 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3638) DUF3645 PF12359.3 KOO28392.1 - 1.5e-14 52.8 0.1 3.2e-14 51.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) GPS PF01825.16 KOO28394.1 - 6.5e-11 42.1 5.9 1.6e-10 40.9 4.1 1.6 1 0 0 1 1 1 1 Latrophilin/CL-1-like GPS domain Asp23 PF03780.8 KOO28394.1 - 0.087 13.1 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Asp23 family Peptidase_S26 PF10502.4 KOO28395.1 - 3.7e-15 55.6 0.0 5.4e-15 55.1 0.0 1.2 1 0 0 1 1 1 1 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.18 KOO28395.1 - 2.4e-11 43.1 0.0 1.5e-10 40.5 0.0 2.1 1 1 0 1 1 1 1 Peptidase S24-like RRM_1 PF00076.17 KOO28396.1 - 8.3e-34 115.0 0.1 3.2e-16 58.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO28396.1 - 1e-27 95.8 0.1 4.6e-13 48.9 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO28396.1 - 3e-13 49.3 0.1 9.2e-06 25.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPT PF03151.11 KOO28397.1 - 1.9e-05 24.3 9.5 2.4e-05 24.0 6.6 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family PRA1 PF03208.14 KOO28397.1 - 0.49 9.7 8.4 3.2 7.0 0.1 2.3 2 0 0 2 2 2 0 PRA1 family protein TMF_DNA_bd PF12329.3 KOO28398.1 - 0.0096 15.7 8.8 0.0096 15.7 6.1 6.9 4 2 4 8 8 8 1 TATA element modulatory factor 1 DNA binding SlyX PF04102.7 KOO28398.1 - 0.03 14.7 1.3 0.03 14.7 0.9 7.4 4 2 2 7 7 7 0 SlyX Reo_sigmaC PF04582.7 KOO28398.1 - 5.9 5.9 21.9 0.78 8.8 0.4 3.9 1 1 3 4 4 4 0 Reovirus sigma C capsid protein 2-oxoacid_dh PF00198.18 KOO28399.1 - 1.5e-65 220.6 0.3 2.1e-65 220.2 0.2 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) E3_binding PF02817.12 KOO28399.1 - 5.5e-29 99.5 0.9 9.5e-17 60.3 0.2 3.3 3 0 0 3 3 3 2 e3 binding domain Biotin_lipoyl PF00364.17 KOO28399.1 - 4.3e-19 67.9 2.1 1e-18 66.7 0.7 2.2 2 0 0 2 2 2 1 Biotin-requiring enzyme IF3_N PF05198.11 KOO28399.1 - 0.12 12.3 0.2 15 5.6 0.1 2.6 1 1 1 2 2 2 0 Translation initiation factor IF-3, N-terminal domain Biotin_lipoyl_2 PF13533.1 KOO28399.1 - 0.14 11.8 3.0 0.58 9.8 0.1 3.0 2 1 1 3 3 3 0 Biotin-lipoyl like HlyD_2 PF12700.2 KOO28399.1 - 0.16 11.0 0.3 7 5.7 0.1 2.1 1 1 1 2 2 2 0 HlyD family secretion protein FA_desaturase PF00487.19 KOO28400.1 - 7.6e-20 71.4 15.2 4.5e-13 49.2 4.2 2.4 2 0 0 2 2 2 2 Fatty acid desaturase CDC37_N PF03234.9 KOO28401.1 - 0.81 9.9 4.9 0.86 9.9 0.0 2.7 2 1 1 3 3 3 0 Cdc37 N terminal kinase binding TMCO5 PF14992.1 KOO28401.1 - 6.3 5.8 7.7 1.1 8.3 0.2 2.6 2 1 0 2 2 2 0 TMCO5 family Prefoldin_2 PF01920.15 KOO28401.1 - 6.9 6.4 14.8 1.5 8.6 0.1 4.4 5 0 0 5 5 5 0 Prefoldin subunit Sulfotransfer_2 PF03567.9 KOO28402.1 - 0.0084 15.8 0.0 0.014 15.0 0.0 1.3 1 1 0 1 1 1 1 Sulfotransferase family TPR_11 PF13414.1 KOO28403.1 - 6.9e-15 54.4 0.9 1.4e-08 34.2 0.0 2.5 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 KOO28403.1 - 1.6e-12 46.3 0.7 0.00093 18.9 0.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOO28403.1 - 9.7e-12 44.6 0.7 5.6e-09 35.8 0.3 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO28403.1 - 7.1e-11 41.2 0.3 0.02 14.5 0.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.1 KOO28403.1 - 7.5e-07 28.9 2.0 0.0016 18.2 0.1 2.3 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO28403.1 - 4.3e-06 27.2 12.5 0.0005 20.6 2.5 2.3 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOO28403.1 - 5.9e-06 26.4 4.5 2 9.0 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOO28403.1 - 1e-05 25.7 2.4 0.00011 22.4 0.6 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_4 PF07721.9 KOO28403.1 - 4.5e-05 23.4 2.9 0.19 12.2 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO28403.1 - 0.00039 20.4 0.8 0.51 10.6 0.1 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.1 KOO28403.1 - 0.00069 19.4 3.5 0.0049 16.7 0.1 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO28403.1 - 0.00092 18.8 2.4 2.1 8.3 0.1 3.9 3 2 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO28403.1 - 0.0012 18.4 0.1 8.1 6.4 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28403.1 - 0.0014 19.0 5.9 1.4 9.7 0.9 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat DUF3856 PF12968.2 KOO28403.1 - 0.0043 16.8 1.3 0.0095 15.7 0.3 1.8 1 1 0 1 1 1 1 Domain of Unknown Function (DUF3856) MIT PF04212.13 KOO28403.1 - 0.054 13.3 0.4 2.2 8.2 0.1 2.3 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain SNAP PF14938.1 KOO28403.1 - 0.075 12.1 0.8 0.36 9.9 1.0 1.7 2 0 0 2 2 2 0 Soluble NSF attachment protein, SNAP BTAD PF03704.12 KOO28403.1 - 0.15 12.3 4.7 3.9 7.7 0.2 2.7 1 1 2 3 3 3 0 Bacterial transcriptional activator domain DEAD PF00270.24 KOO28404.1 - 1.3e-36 125.6 0.1 2.3e-36 124.8 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO28404.1 - 7.8e-27 92.9 0.0 9.7e-26 89.4 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain CMS1 PF14617.1 KOO28404.1 - 0.00062 18.9 0.1 0.0016 17.5 0.0 1.7 1 1 1 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.10 KOO28404.1 - 0.00066 19.5 0.1 0.0023 17.7 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF1253 PF06862.7 KOO28404.1 - 0.0049 15.3 0.1 0.011 14.1 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1253) Oxidored_nitro PF00148.14 KOO28404.1 - 0.094 11.3 0.0 0.49 8.9 0.0 2.1 1 1 1 2 2 2 0 Nitrogenase component 1 type Oxidoreductase ChaC PF04752.7 KOO28404.1 - 0.13 12.1 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 ChaC-like protein Methyltransf_11 PF08241.7 KOO28405.1 - 9.7e-14 51.6 0.0 7e-13 48.8 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO28405.1 - 5.9e-13 49.0 0.0 6.3e-11 42.5 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO28405.1 - 1.5e-11 44.8 0.0 7.5e-11 42.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO28405.1 - 2.6e-10 40.3 1.2 6.1e-10 39.1 0.3 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO28405.1 - 4.6e-10 39.4 0.0 7.2e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO28405.1 - 1.1e-07 32.2 0.0 4.2e-07 30.3 0.0 2.0 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO28405.1 - 1.5e-05 24.6 0.0 5e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO28405.1 - 5.5e-05 22.4 0.0 0.0002 20.5 0.0 1.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_24 PF13578.1 KOO28405.1 - 0.0034 18.1 0.1 0.017 15.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.8 KOO28405.1 - 0.005 15.9 0.0 0.007 15.5 0.0 1.3 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 KOO28405.1 - 0.015 14.6 0.0 0.062 12.6 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_32 PF13679.1 KOO28405.1 - 0.02 14.5 0.0 0.14 11.8 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_3 PF01596.12 KOO28405.1 - 0.022 13.7 0.0 0.61 9.1 0.0 2.2 1 1 0 1 1 1 0 O-methyltransferase Methyltransf_2 PF00891.13 KOO28405.1 - 0.042 13.0 0.0 0.22 10.7 0.0 2.1 1 1 0 1 1 1 0 O-methyltransferase Methyltransf_9 PF08003.6 KOO28405.1 - 0.092 11.4 0.0 0.16 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_4 PF02390.12 KOO28405.1 - 0.14 11.2 0.0 0.26 10.3 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Arm PF00514.18 KOO28406.1 - 5.6e-17 60.8 10.8 2.2e-06 27.2 0.1 7.2 5 2 1 6 6 6 5 Armadillo/beta-catenin-like repeat Mo25 PF08569.6 KOO28406.1 - 0.22 10.5 0.0 0.56 9.1 0.0 1.6 2 0 0 2 2 2 0 Mo25-like Rhodanese PF00581.15 KOO28407.1 - 8.3e-07 29.3 0.0 1.9e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain CCDC155 PF14662.1 KOO28408.1 - 0.0032 17.0 13.9 0.0044 16.6 9.6 1.1 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 FTA2 PF13095.1 KOO28408.1 - 0.089 12.3 0.4 0.12 11.9 0.3 1.1 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 DDE_Tnp_IS66 PF03050.9 KOO28408.1 - 1.8 7.7 10.4 8.8 5.4 5.2 2.0 2 0 0 2 2 2 0 Transposase IS66 family Tho2 PF11262.3 KOO28408.1 - 2.4 7.1 7.0 3.4 6.6 4.9 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 V_ATPase_I PF01496.14 KOO28408.1 - 7.1 4.3 6.8 8.7 4.0 4.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ORC4_C PF14629.1 KOO28409.1 - 8.8e-14 51.3 0.1 1.3e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.1 KOO28409.1 - 1.5e-07 31.5 8.2 6.9e-07 29.4 0.2 3.6 3 2 1 4 4 4 1 AAA ATPase domain AAA PF00004.24 KOO28409.1 - 0.0093 16.1 0.0 0.17 12.0 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 KOO28409.1 - 0.097 12.3 0.0 0.24 11.0 0.0 1.6 2 0 0 2 2 2 0 Archaeal ATPase Ank_2 PF12796.2 KOO28410.1 - 7.6e-33 112.7 0.9 1.5e-16 60.5 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO28410.1 - 6.6e-20 69.8 0.2 1.1e-08 34.4 0.1 3.3 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 KOO28410.1 - 2.6e-17 62.8 2.9 4.8e-07 30.1 0.1 2.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO28410.1 - 4e-13 49.1 0.5 2.4e-06 27.5 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO28410.1 - 8.3e-10 37.9 0.3 0.00021 21.2 0.0 2.7 3 0 0 3 3 3 2 Ankyrin repeat DSS1_SEM1 PF05160.8 KOO28410.1 - 5.8 6.7 9.8 1.7 8.4 4.5 1.8 2 0 0 2 2 2 0 DSS1/SEM1 family Ribosomal_L6 PF00347.18 KOO28411.1 - 1.2e-09 38.4 0.1 0.0009 19.6 0.0 3.1 3 0 0 3 3 3 2 Ribosomal protein L6 TRAM_LAG1_CLN8 PF03798.11 KOO28412.1 - 3e-14 53.0 4.7 3.5e-14 52.8 3.3 1.0 1 0 0 1 1 1 1 TLC domain PNP_UDP_1 PF01048.15 KOO28413.1 - 1.4e-17 63.4 6.3 2.7e-17 62.5 4.4 1.5 1 0 0 1 1 1 1 Phosphorylase superfamily 2OG-FeII_Oxy PF03171.15 KOO28413.1 - 0.059 13.6 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Acetyltransf_1 PF00583.19 KOO28415.1 - 8.7e-05 22.4 3.5 0.0005 20.0 0.1 3.6 4 0 0 4 4 4 1 Acetyltransferase (GNAT) family SET PF00856.23 KOO28415.1 - 0.00087 19.6 0.0 0.011 16.0 0.0 2.4 1 1 0 1 1 1 1 SET domain Acetyltransf_7 PF13508.1 KOO28415.1 - 0.25 11.5 0.0 0.5 10.5 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain HpaP PF09483.5 KOO28416.1 - 1 9.2 14.3 1.5 8.7 9.9 1.2 1 0 0 1 1 1 0 Type III secretion protein (HpaP) KLRAQ PF10205.4 KOO28417.1 - 0.4 10.7 13.1 1 9.4 0.4 3.7 2 2 1 4 4 4 0 Predicted coiled-coil domain-containing protein Adeno_PIX PF03955.9 KOO28417.1 - 5.4 7.5 8.7 0.87 10.1 0.2 2.9 3 0 0 3 3 3 0 Adenovirus hexon-associated protein (IX) Exo_endo_phos PF03372.18 KOO28418.1 - 3.1e-15 56.8 0.0 2.7e-12 47.1 0.0 2.1 1 1 1 2 2 2 2 Endonuclease/Exonuclease/phosphatase family MFS_1 PF07690.11 KOO28419.1 - 8.2e-39 133.2 36.3 2.8e-23 82.2 10.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KOO28419.1 - 2.4e-11 42.6 9.7 1.3e-09 36.9 6.9 2.1 1 1 0 1 1 1 1 MFS/sugar transport protein MFS_3 PF05977.8 KOO28419.1 - 6.1e-09 34.5 20.8 5.9e-06 24.6 6.4 2.2 2 0 0 2 2 2 2 Transmembrane secretion effector LacY_symp PF01306.14 KOO28419.1 - 0.02 13.4 3.5 0.27 9.7 0.1 2.4 2 0 0 2 2 2 0 LacY proton/sugar symporter OATP PF03137.15 KOO28419.1 - 0.3 9.0 5.9 0.65 7.9 0.3 2.3 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Pam17 PF08566.5 KOO28419.1 - 3.7 7.2 4.7 13 5.4 0.1 3.0 3 0 0 3 3 3 0 Mitochondrial import protein Pam17 ENTH PF01417.15 KOO28420.1 - 2.2e-60 202.0 0.0 4.3e-39 133.2 0.0 2.1 2 0 0 2 2 2 2 ENTH domain ANTH PF07651.11 KOO28420.1 - 5.4e-09 35.1 0.0 0.001 17.8 0.0 2.1 2 0 0 2 2 2 2 ANTH domain Med3 PF11593.3 KOO28420.1 - 0.65 9.1 11.9 0.33 10.1 6.5 1.8 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal UbiA PF01040.13 KOO28421.1 - 5.7e-26 91.2 18.6 7.6e-26 90.8 12.9 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family SET PF00856.23 KOO28423.1 - 4.1e-27 95.4 4.4 4.6e-27 95.3 0.1 2.8 3 1 0 3 3 3 1 SET domain Pre-SET PF05033.11 KOO28423.1 - 4.2e-07 30.1 0.0 1.4e-06 28.5 0.0 2.0 2 0 0 2 2 2 1 Pre-SET motif LRR_6 PF13516.1 KOO28424.1 - 2.7e-09 36.1 5.6 0.0093 15.9 0.0 4.8 4 1 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.2 KOO28424.1 - 1.1e-05 24.9 0.1 0.032 13.8 0.0 3.1 3 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO28424.1 - 0.0017 18.0 0.8 5.4 7.4 0.0 4.2 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_7 PF13504.1 KOO28424.1 - 0.24 11.7 6.6 19 6.0 0.0 4.7 5 1 1 6 6 6 0 Leucine rich repeat DUF3450 PF11932.3 KOO28425.1 - 0.11 11.7 2.0 3.6 6.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) PMC2NT PF08066.7 KOO28425.1 - 0.14 12.5 1.4 3 8.1 0.2 2.2 2 1 0 2 2 2 0 PMC2NT (NUC016) domain IncA PF04156.9 KOO28425.1 - 0.15 11.6 5.3 2.8 7.5 0.2 2.1 2 0 0 2 2 2 0 IncA protein CorA PF01544.13 KOO28425.1 - 0.34 9.8 2.1 0.45 9.5 1.5 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein EF-hand_1 PF00036.27 KOO28426.1 - 4.2e-10 38.1 2.6 0.089 12.1 0.1 4.6 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO28426.1 - 9.7e-09 34.7 1.6 0.28 10.8 0.1 4.4 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO28426.1 - 1.8e-07 30.1 12.4 0.022 14.0 0.5 4.6 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.1 KOO28426.1 - 1.4e-05 25.0 2.3 5 7.3 0.0 4.3 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO28426.1 - 1.8e-05 24.2 4.6 1.2 9.2 0.1 4.8 5 0 0 5 5 5 2 EF-hand domain MxiH PF09392.5 KOO28426.1 - 3.4 8.2 0.0 3.4 8.2 0.0 17.2 3 2 3 6 6 6 0 Type III secretion needle MxiH like Cupin_8 PF13621.1 KOO28426.1 - 6.2 6.2 4.2 22 4.4 2.4 2.3 1 1 0 1 1 1 0 Cupin-like domain PRK PF00485.13 KOO28427.1 - 5.8e-39 133.6 0.0 8.4e-39 133.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.1 KOO28427.1 - 8.6e-10 39.0 0.0 1.3e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO28427.1 - 3e-09 37.7 0.1 5.1e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOO28427.1 - 1.3e-06 27.6 0.1 4.9e-06 25.7 0.0 1.9 2 1 0 2 2 2 1 Zeta toxin AAA_16 PF13191.1 KOO28427.1 - 2e-05 24.6 0.0 3.4e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 KOO28427.1 - 3.2e-05 23.8 0.1 7.6e-05 22.6 0.0 1.6 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 KOO28427.1 - 4.3e-05 23.2 0.1 0.00013 21.7 0.1 1.8 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_26 PF13500.1 KOO28427.1 - 0.00047 19.8 0.0 0.0013 18.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.22 KOO28427.1 - 0.0008 19.7 0.0 0.002 18.4 0.0 1.5 1 1 0 1 1 1 1 ABC transporter KTI12 PF08433.5 KOO28427.1 - 0.0022 17.2 0.0 0.0043 16.2 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 IstB_IS21 PF01695.12 KOO28427.1 - 0.0029 17.0 0.0 0.0042 16.5 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein APS_kinase PF01583.15 KOO28427.1 - 0.0032 17.1 0.0 0.009 15.6 0.0 1.7 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_19 PF13245.1 KOO28427.1 - 0.0038 16.9 0.0 0.015 15.0 0.0 2.1 1 0 0 1 1 1 1 Part of AAA domain AAA_10 PF12846.2 KOO28427.1 - 0.0057 16.1 0.0 0.011 15.2 0.0 1.4 1 1 0 1 1 1 1 AAA-like domain T2SE PF00437.15 KOO28427.1 - 0.0077 15.1 0.0 0.013 14.4 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein CoaE PF01121.15 KOO28427.1 - 0.009 15.4 1.6 0.056 12.8 0.2 2.1 2 0 0 2 2 2 1 Dephospho-CoA kinase SRP54 PF00448.17 KOO28427.1 - 0.0097 15.3 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain NB-ARC PF00931.17 KOO28427.1 - 0.0097 14.7 0.0 0.014 14.2 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain Thymidylate_kin PF02223.12 KOO28427.1 - 0.013 14.9 0.1 0.066 12.5 0.0 2.0 2 0 0 2 2 2 0 Thymidylate kinase AAA_22 PF13401.1 KOO28427.1 - 0.013 15.6 0.0 0.029 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 KOO28427.1 - 0.015 15.5 0.0 0.024 14.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 KOO28427.1 - 0.024 14.6 0.0 0.039 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain ArgK PF03308.11 KOO28427.1 - 0.027 13.2 0.0 0.056 12.2 0.0 1.4 1 0 0 1 1 1 0 ArgK protein CbiA PF01656.18 KOO28427.1 - 0.029 13.8 0.0 0.042 13.2 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain RNA_helicase PF00910.17 KOO28427.1 - 0.04 14.1 0.0 0.066 13.3 0.0 1.3 1 0 0 1 1 1 0 RNA helicase TrwB_AAD_bind PF10412.4 KOO28427.1 - 0.04 12.5 0.0 0.062 11.9 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain DUF87 PF01935.12 KOO28427.1 - 0.055 13.2 0.0 0.092 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF87 NTPase_1 PF03266.10 KOO28427.1 - 0.056 13.1 0.0 0.097 12.3 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_30 PF13604.1 KOO28427.1 - 0.057 13.0 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 KOO28427.1 - 0.13 11.9 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA PF00004.24 KOO28427.1 - 0.13 12.4 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Ank_2 PF12796.2 KOO28428.1 - 7.4e-24 83.9 0.1 1.7e-13 50.6 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO28428.1 - 2.1e-21 74.5 0.2 3.8e-07 29.5 0.0 5.0 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.1 KOO28428.1 - 3.6e-21 74.6 4.1 5.4e-09 36.0 0.1 4.3 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO28428.1 - 7.8e-21 72.0 0.0 6.7e-05 22.7 0.0 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.1 KOO28428.1 - 4.3e-15 55.7 0.0 9.8e-07 29.1 0.0 3.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) SHIPPO-rpt PF07004.7 KOO28431.1 - 0.1 13.5 2.2 7.6 7.6 0.2 2.8 2 1 0 2 2 2 0 Sperm-tail PG-rich repeat RMMBL PF07521.7 KOO28433.1 - 0.073 12.9 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 RNA-metabolising metallo-beta-lactamase Tn7_TnsC_Int PF11426.3 KOO28433.1 - 0.087 12.5 0.0 0.25 11.1 0.0 1.8 1 0 0 1 1 1 0 Tn7 transposition regulator TnsC Permease PF02405.11 KOO28434.1 - 1.8e-22 79.8 7.5 1.8e-22 79.8 5.2 2.0 2 0 0 2 2 2 1 Permease AAA_21 PF13304.1 KOO28434.1 - 0.0016 18.4 0.0 0.0024 17.8 0.0 1.1 1 0 0 1 1 1 1 AAA domain SbcCD_C PF13558.1 KOO28434.1 - 0.0076 16.1 0.0 0.043 13.7 0.0 2.3 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit FixP_N PF14715.1 KOO28436.1 - 0.48 9.8 2.7 1.4 8.3 1.9 1.8 1 0 0 1 1 1 0 N-terminal domain of cytochrome oxidase-cbb3, FixP DUF3021 PF11457.3 KOO28436.1 - 1.2 9.0 11.1 0.25 11.2 4.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3021) Phage_integrase PF00589.17 KOO28437.1 - 0.0044 16.6 0.0 0.0074 15.9 0.0 1.5 1 0 0 1 1 1 1 Phage integrase family Abhydrolase_6 PF12697.2 KOO28440.1 - 1.1e-10 41.8 0.6 1.3e-10 41.5 0.4 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO28440.1 - 0.03 13.8 0.0 0.038 13.5 0.0 1.1 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 KOO28440.1 - 0.032 14.0 0.0 0.043 13.5 0.0 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family SpoIIE PF07228.7 KOO28441.1 - 8.4e-13 48.4 0.0 1.2e-12 47.8 0.0 1.3 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 KOO28441.1 - 0.00045 19.6 0.1 0.00088 18.7 0.1 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.16 KOO28441.1 - 0.08 12.3 0.0 2.1 7.6 0.0 2.2 2 0 0 2 2 2 0 Protein phosphatase 2C EF-hand_7 PF13499.1 KOO28442.1 - 2.3e-18 66.0 0.2 3.8e-08 33.3 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO28442.1 - 2.5e-16 58.0 0.6 0.0013 18.4 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.27 KOO28442.1 - 3.9e-15 53.9 0.1 0.0008 18.5 0.0 4.5 4 0 0 4 4 4 3 EF hand GPS PF01825.16 KOO28442.1 - 2.9e-11 43.2 3.7 5.9e-11 42.2 2.5 1.5 1 0 0 1 1 1 1 Latrophilin/CL-1-like GPS domain EF-hand_5 PF13202.1 KOO28442.1 - 7.4e-11 40.8 0.2 0.00087 18.5 0.0 4.5 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO28442.1 - 2.3e-05 23.8 0.1 0.0099 15.4 0.0 3.0 2 1 1 3 3 3 1 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO28442.1 - 0.085 12.8 0.0 3.4 7.7 0.0 2.4 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF937 PF06078.6 KOO28442.1 - 0.38 10.9 11.8 0.035 14.3 3.5 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF937) Myosin_tail_1 PF01576.14 KOO28443.1 - 0.29 8.8 70.2 0.032 11.9 13.1 4.1 2 1 2 4 4 4 0 Myosin tail RCC1 PF00415.13 KOO28445.1 - 3.3e-21 75.2 4.4 6.7e-07 29.4 0.2 4.7 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat Ank_2 PF12796.2 KOO28445.1 - 1.7e-08 34.6 1.8 2.4e-08 34.1 0.3 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO28445.1 - 1.4e-06 28.6 0.3 6.7e-06 26.4 0.2 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO28445.1 - 2.2e-06 27.1 0.4 2.2e-06 27.1 0.3 3.0 3 0 0 3 3 3 1 Ankyrin repeat RCC1_2 PF13540.1 KOO28445.1 - 2.8e-06 26.7 27.8 0.0021 17.5 1.9 4.7 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat Ank_3 PF13606.1 KOO28445.1 - 5.1e-05 23.1 1.4 0.0018 18.3 0.2 3.0 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.1 KOO28445.1 - 0.00037 20.6 2.6 0.00076 19.6 0.5 2.7 2 1 0 2 2 2 1 Ankyrin repeats (many copies) DUF4490 PF14892.1 KOO28446.1 - 0.0094 15.5 0.0 0.024 14.3 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4490) FA_desaturase PF00487.19 KOO28448.1 - 1.6e-16 60.5 20.2 1.6e-16 60.5 14.0 1.4 1 1 0 1 1 1 1 Fatty acid desaturase WHEP-TRS PF00458.15 KOO28449.1 - 0.0045 16.6 0.1 0.0079 15.8 0.1 1.4 1 0 0 1 1 1 1 WHEP-TRS domain Exostosin PF03016.10 KOO28450.1 - 2.4e-06 26.8 0.0 4e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Exostosin family Fer2_3 PF13085.1 KOO28451.1 - 2.4e-31 107.7 0.0 4e-31 107.0 0.0 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.1 KOO28451.1 - 6.9e-09 35.9 5.6 6.9e-09 35.9 3.9 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.1 KOO28451.1 - 2.9e-08 33.6 4.3 2.9e-08 33.6 2.9 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_18 PF13746.1 KOO28451.1 - 0.00021 21.6 1.5 0.00021 21.6 1.0 2.8 2 2 1 3 3 3 2 4Fe-4S dicluster domain Fer2 PF00111.22 KOO28451.1 - 0.0034 17.0 1.1 0.0034 17.0 0.8 2.3 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_10 PF13237.1 KOO28451.1 - 0.01 15.6 6.5 0.01 15.6 4.5 2.5 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_7 PF12838.2 KOO28451.1 - 0.015 15.6 6.5 0.015 15.6 4.5 2.7 2 2 0 2 2 2 0 4Fe-4S dicluster domain Fer4_9 PF13187.1 KOO28451.1 - 0.033 14.4 11.3 0.041 14.1 0.5 3.0 3 1 0 3 3 3 0 4Fe-4S dicluster domain Fer4_15 PF13459.1 KOO28451.1 - 0.077 13.5 1.4 5.8 7.5 0.1 2.6 2 0 0 2 2 2 0 4Fe-4S single cluster domain DUF482 PF04339.7 KOO28452.1 - 4.2e-42 144.3 0.0 1.7e-21 76.5 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function, DUF482 Acetyltransf_6 PF13480.1 KOO28452.1 - 0.00049 20.0 0.0 0.00065 19.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF2959 PF11172.3 KOO28453.1 - 0.014 15.1 5.0 0.023 14.4 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2959) DivIC PF04977.10 KOO28453.1 - 10 5.7 9.7 30 4.1 6.7 1.7 1 0 0 1 1 1 0 Septum formation initiator PHD PF00628.24 KOO28454.1 - 4e-10 39.2 6.7 7.2e-10 38.4 4.7 1.4 1 0 0 1 1 1 1 PHD-finger WHIM2 PF15613.1 KOO28454.1 - 0.0015 18.4 0.0 0.003 17.4 0.0 1.5 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 2 LRR_6 PF13516.1 KOO28457.1 - 7.3e-19 65.6 11.8 0.034 14.2 0.0 8.1 8 0 0 8 8 8 6 Leucine Rich repeat LRR_1 PF00560.28 KOO28457.1 - 0.0032 17.2 0.1 12 6.3 0.0 5.4 6 0 0 6 6 6 1 Leucine Rich Repeat DUF3197 PF11432.3 KOO28457.1 - 0.03 14.3 0.6 9 6.3 0.0 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3197) LRR_7 PF13504.1 KOO28457.1 - 0.049 13.8 8.9 25 5.6 0.0 7.0 9 0 0 9 9 9 0 Leucine rich repeat HHH_5 PF14520.1 KOO28457.1 - 7.7 6.7 7.6 30 4.8 0.3 3.5 3 1 0 3 3 3 0 Helix-hairpin-helix domain TP_methylase PF00590.15 KOO28458.1 - 1.2e-29 103.5 1.2 1.2e-29 103.5 0.9 1.4 2 0 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Chloroa_b-bind PF00504.16 KOO28459.1 - 1.7e-34 119.3 0.0 2.4e-34 118.8 0.0 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein DUF2905 PF11146.3 KOO28459.1 - 0.19 11.6 1.3 20 5.2 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2905) Ion_trans PF00520.26 KOO28460.1 - 5.1e-13 48.7 14.3 5.1e-13 48.7 9.9 1.9 2 1 0 2 2 2 1 Ion transport protein cNMP_binding PF00027.24 KOO28460.1 - 1.4e-11 44.0 0.0 3e-11 42.9 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.11 KOO28460.1 - 2.5e-11 43.1 7.2 2.5e-11 43.1 5.0 2.1 2 1 0 2 2 2 1 Ion channel Ion_trans_N PF08412.5 KOO28460.1 - 0.021 14.1 0.3 0.077 12.3 0.0 2.1 2 0 0 2 2 2 0 Ion transport protein N-terminal Glucan_synthase PF02364.10 KOO28461.1 - 2.3e-106 356.6 2.9 1.8e-86 290.7 1.8 3.0 1 1 1 2 2 2 2 1,3-beta-glucan synthase component Ion_trans PF00520.26 KOO28461.1 - 0.0053 16.0 0.2 0.0097 15.1 0.1 1.3 1 0 0 1 1 1 1 Ion transport protein Thioredoxin PF00085.15 KOO28463.1 - 3.8e-16 58.6 0.0 8.2e-16 57.5 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_6 PF13848.1 KOO28463.1 - 0.00064 19.5 0.0 0.0026 17.5 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin-like domain DUF3456 PF11938.3 KOO28463.1 - 0.02 14.9 1.4 0.13 12.2 0.6 2.4 1 1 1 2 2 2 0 TLR4 regulator and MIR-interacting MSAP Glyco_tranf_2_3 PF13641.1 KOO28466.1 - 5.7e-26 91.7 0.0 7.5e-26 91.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 KOO28466.1 - 8.2e-20 71.3 1.7 1.6e-19 70.3 1.2 1.4 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.1 KOO28466.1 - 2.7e-12 46.3 0.0 4.4e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 KOO28466.1 - 0.00014 21.5 0.0 0.00023 20.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ribosomal_L35Ae PF01247.13 KOO28467.1 - 8.7e-41 137.6 0.8 1.5e-40 136.8 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein L35Ae Sel1 PF08238.7 KOO28468.1 - 0.00022 21.7 0.2 0.0019 18.8 0.0 2.7 2 0 0 2 2 2 1 Sel1 repeat Aldo_ket_red PF00248.16 KOO28469.1 - 3.4e-49 167.1 0.0 4.1e-49 166.9 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Cupin_8 PF13621.1 KOO28470.1 - 1.9e-08 34.1 0.0 0.014 14.8 0.0 3.2 3 0 0 3 3 3 3 Cupin-like domain Cupin_4 PF08007.7 KOO28470.1 - 0.087 12.0 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Cupin superfamily protein DUF3508 PF12018.3 KOO28471.1 - 2.1e-15 56.4 1.1 3.4e-15 55.7 0.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3508) YlqD PF11068.3 KOO28471.1 - 0.31 11.0 3.4 1.3 9.1 0.7 2.7 2 1 1 3 3 3 0 YlqD protein Malic_M PF03949.10 KOO28472.1 - 3.8e-78 262.5 0.1 4.8e-78 262.2 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.14 KOO28472.1 - 9.7e-67 224.0 0.0 2.1e-66 222.9 0.0 1.6 2 0 0 2 2 2 1 Malic enzyme, N-terminal domain Pyr_redox_2 PF07992.9 KOO28472.1 - 0.069 13.0 0.4 0.13 12.1 0.3 1.5 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 KOO28472.1 - 0.28 10.8 0.8 0.47 10.0 0.5 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1846 PF08903.6 KOO28473.1 - 0.11 10.8 0.0 0.15 10.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1846) EXS PF03124.9 KOO28474.1 - 1.2e-60 205.3 14.8 1.6e-60 204.9 10.3 1.1 1 0 0 1 1 1 1 EXS family PalH PF08733.5 KOO28474.1 - 0.017 13.9 2.5 0.035 12.9 1.7 1.4 1 0 0 1 1 1 0 PalH/RIM21 ARL2_Bind_BART PF11527.3 KOO28475.1 - 2e-07 30.8 0.0 3.4e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART NYN PF01936.13 KOO28475.1 - 1.2e-05 25.6 0.0 3e-05 24.3 0.0 1.6 2 0 0 2 2 2 1 NYN domain CSD PF00313.17 KOO28475.1 - 0.0012 18.6 0.0 0.0025 17.5 0.0 1.5 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain Cornifin PF02389.10 KOO28476.1 - 0.033 13.9 0.2 0.068 12.9 0.2 1.5 1 0 0 1 1 1 0 Cornifin (SPRR) family HC2 PF07382.6 KOO28477.1 - 0.004 17.0 14.7 0.0061 16.4 10.2 1.2 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 Staphylcoagulse PF04022.7 KOO28477.1 - 1.8 7.9 4.5 0.48 9.8 0.3 2.2 2 0 0 2 2 2 0 Staphylocoagulase repeat DUF4279 PF14106.1 KOO28478.1 - 0.027 14.3 4.1 1.3 8.9 0.1 4.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4279) Surfac_D-trimer PF09006.6 KOO28478.1 - 7.9 6.3 7.3 5.4 6.8 0.2 3.6 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation Inhibitor_I29 PF08246.7 KOO28479.1 - 0.21 11.8 0.2 0.21 11.8 0.1 3.0 2 1 1 3 3 3 0 Cathepsin propeptide inhibitor domain (I29) EF-hand_1 PF00036.27 KOO28480.1 - 3.5e-19 66.5 8.8 0.00069 18.7 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO28480.1 - 3e-17 60.8 5.7 0.0023 17.6 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO28480.1 - 4.1e-15 55.6 4.3 1.9e-05 24.7 0.0 3.6 2 2 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO28480.1 - 5.8e-13 48.2 6.6 5.5e-06 25.8 0.1 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO28480.1 - 3.5e-11 41.9 11.5 0.00035 19.7 0.1 4.5 4 0 0 4 4 4 3 EF hand EF-hand_10 PF14788.1 KOO28480.1 - 0.0014 18.2 0.2 8.9 6.0 0.0 4.2 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.4 KOO28480.1 - 0.61 10.1 8.9 3.1 7.8 0.7 3.4 2 2 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region TRAPPC9-Trs120 PF08626.6 KOO28481.1 - 4.8e-20 70.6 0.0 1.1e-09 36.3 0.0 2.2 2 0 0 2 2 2 2 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit TRAPPC-Trs85 PF12739.2 KOO28481.1 - 0.0028 16.3 0.2 0.0046 15.6 0.1 1.5 1 1 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit DUF2383 PF09537.5 KOO28481.1 - 0.039 14.1 1.0 0.095 12.9 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2383) Poxvirus_B22R_N PF13169.1 KOO28482.1 - 0.069 13.3 0.7 0.21 11.7 0.1 2.1 1 1 0 2 2 2 0 Poxvirus B22R protein N-terminal DUF1844 PF08899.6 KOO28482.1 - 0.46 10.4 3.5 0.31 11.0 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1844) PLRV_ORF5 PF01690.12 KOO28482.1 - 3 6.8 15.1 3.8 6.5 10.5 1.1 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein DUF3540 PF12059.3 KOO28483.1 - 0.015 14.9 1.1 0.015 14.9 0.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3540) FUSC PF04632.7 KOO28483.1 - 0.42 8.9 17.4 0.51 8.7 12.1 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family APG6 PF04111.7 KOO28483.1 - 3 6.8 19.3 2.8 6.9 5.3 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 RmuC PF02646.11 KOO28483.1 - 3.3 6.4 11.3 0.14 10.9 1.8 2.1 2 0 0 2 2 2 0 RmuC family SIMPL PF04402.9 KOO28483.1 - 3.9 7.2 10.7 13 5.5 7.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF541) GrpE PF01025.14 KOO28483.1 - 5 6.6 17.6 0.86 9.1 2.0 2.1 2 0 0 2 2 2 0 GrpE Cut12 PF11500.3 KOO28483.1 - 6.1 6.5 13.4 3.8 7.1 1.2 2.2 2 0 0 2 2 2 0 Spindle pole body formation-associated protein AAA PF00004.24 KOO28484.1 - 8.2e-19 68.1 0.0 2.1e-18 66.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IQ PF00612.22 KOO28484.1 - 0.0008 18.8 1.0 0.002 17.6 0.7 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif Sigma54_activ_2 PF14532.1 KOO28484.1 - 0.038 14.0 0.0 0.12 12.4 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_5 PF07728.9 KOO28484.1 - 0.053 13.2 0.0 0.18 11.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 KOO28484.1 - 0.072 13.9 1.7 0.23 12.2 0.0 2.8 3 0 0 3 3 3 0 AAA domain DUF2828 PF11443.3 KOO28486.1 - 1.8e-08 33.0 0.4 4.4e-06 25.2 0.5 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF2828) VWA_2 PF13519.1 KOO28486.1 - 0.0013 18.8 0.8 0.0061 16.6 0.0 2.5 2 1 0 2 2 2 1 von Willebrand factor type A domain LUC7 PF03194.10 KOO28486.1 - 0.33 10.4 4.1 0.11 11.9 0.9 1.5 2 0 0 2 2 2 0 LUC7 N_terminus Motile_Sperm PF00635.21 KOO28487.1 - 7.3e-18 64.2 0.6 1.3e-17 63.4 0.4 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain TPR_11 PF13414.1 KOO28487.1 - 1.4e-12 47.0 0.6 2.6e-05 23.7 0.1 4.2 1 1 2 3 3 3 3 TPR repeat TPR_16 PF13432.1 KOO28487.1 - 4.4e-07 30.4 21.7 0.00016 22.2 0.7 5.0 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO28487.1 - 4.8e-07 29.1 3.8 0.0039 17.0 0.3 5.3 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO28487.1 - 9.2e-05 21.8 3.4 0.0032 16.9 0.1 4.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOO28487.1 - 0.00028 20.7 14.6 0.0013 18.5 1.0 4.2 2 1 4 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO28487.1 - 0.0049 16.9 0.2 0.31 11.3 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO28487.1 - 0.07 13.4 13.0 0.12 12.7 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28487.1 - 0.21 12.2 26.4 0.12 13.0 1.1 6.3 2 2 5 7 7 7 0 Tetratricopeptide repeat EF-hand_1 PF00036.27 KOO28488.1 - 1.2e-41 136.8 16.9 5e-08 31.6 0.2 6.5 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.1 KOO28488.1 - 2.5e-39 129.5 19.1 7.7e-07 28.4 0.2 6.9 6 0 0 6 6 6 6 EF-hand domain EF-hand_5 PF13202.1 KOO28488.1 - 1.1e-35 119.3 27.3 4.1e-07 29.0 0.2 6.6 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.1 KOO28488.1 - 5.8e-35 119.2 8.4 6.6e-12 45.3 0.2 3.6 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO28488.1 - 9.4e-24 82.7 17.9 1.4e-06 27.8 0.8 6.4 4 2 2 6 6 6 6 EF-hand domain pair EF-hand_9 PF14658.1 KOO28488.1 - 0.00049 19.9 0.0 1.6 8.7 0.0 4.4 4 0 0 4 4 4 1 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO28488.1 - 0.001 19.0 0.3 9.3 6.3 0.0 4.2 4 2 1 5 5 5 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO28488.1 - 0.019 14.6 3.3 21 4.8 0.0 5.2 6 0 0 6 6 6 0 EF hand EF-hand_4 PF12763.2 KOO28488.1 - 0.081 12.6 2.0 8 6.2 0.1 3.3 3 1 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand DUF2681 PF10883.3 KOO28488.1 - 0.091 12.9 4.4 0.21 11.8 3.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Mnd1 PF03962.10 KOO28488.1 - 0.096 12.3 4.0 0.2 11.2 2.8 1.5 1 0 0 1 1 1 0 Mnd1 family DUF3584 PF12128.3 KOO28488.1 - 0.14 9.4 11.6 0.44 7.8 8.5 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Mitofilin PF09731.4 KOO28488.1 - 0.23 10.1 17.4 0.35 9.4 12.1 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein BRE1 PF08647.6 KOO28488.1 - 1.6 8.7 12.3 4.3 7.3 7.0 2.6 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase SAM_1 PF00536.25 KOO28489.1 - 2.8e-05 24.1 0.2 7.2e-05 22.8 0.1 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 KOO28489.1 - 0.00087 19.0 0.2 0.003 17.3 0.1 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.11 KOO28489.1 - 0.055 13.2 0.1 0.14 11.9 0.1 1.6 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Dermcidin PF15291.1 KOO28489.1 - 0.58 10.3 7.6 4.3 7.5 0.1 3.6 3 0 0 3 3 3 0 Dermcidin, antibiotic peptide Radical_SAM PF04055.16 KOO28490.1 - 1.7e-31 109.6 0.0 5.7e-31 107.9 0.0 1.9 2 0 0 2 2 2 1 Radical SAM superfamily UPF0004 PF00919.15 KOO28490.1 - 1.8e-22 78.9 0.0 6.9e-22 77.1 0.0 2.0 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 Rotamase_3 PF13616.1 KOO28490.1 - 1.9e-11 44.2 0.0 8.4e-11 42.1 0.0 1.9 2 0 0 2 2 2 1 PPIC-type PPIASE domain Rotamase PF00639.16 KOO28490.1 - 5.6e-09 36.6 0.0 1.7e-08 35.1 0.0 1.8 1 0 0 1 1 1 1 PPIC-type PPIASE domain TRAM PF01938.15 KOO28490.1 - 5.8e-09 35.6 0.0 1.1e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 TRAM domain Ribosomal_L10 PF00466.15 KOO28491.1 - 4.7e-14 52.1 0.0 6.4e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 DUF2809 PF10990.3 KOO28491.1 - 0.0082 16.5 0.0 0.015 15.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2809) Semialdhyde_dhC PF02774.13 KOO28491.1 - 0.17 11.7 0.9 0.37 10.6 0.1 1.9 2 1 1 3 3 3 0 Semialdehyde dehydrogenase, dimerisation domain Tic22 PF04278.7 KOO28492.1 - 4.2e-08 32.8 0.0 5.3e-07 29.1 0.0 2.1 1 1 0 1 1 1 1 Tic22-like family DUF3589 PF12141.3 KOO28492.1 - 0.0071 14.6 0.0 0.01 14.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3589) Methyltransf_9 PF08003.6 KOO28492.1 - 0.2 10.2 0.0 0.35 9.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Ion_trans PF00520.26 KOO28493.1 - 9.5e-06 24.9 6.0 2.6e-05 23.5 4.2 1.6 1 1 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO28493.1 - 0.11 12.1 5.7 0.25 11.1 3.9 1.7 1 1 0 1 1 1 0 Ion channel Yip1 PF04893.12 KOO28493.1 - 4.4 6.7 10.0 17 4.8 7.0 1.7 1 1 0 1 1 1 0 Yip1 domain Sulfatase PF00884.18 KOO28494.1 - 5.5e-22 78.3 0.0 1.4e-21 77.0 0.0 1.6 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.17 KOO28494.1 - 4.7e-05 22.8 0.0 0.0028 17.0 0.0 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase UCH PF00443.24 KOO28495.1 - 9.5e-20 70.8 0.9 2.3e-19 69.5 0.0 1.8 2 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.7 KOO28495.1 - 5e-12 46.0 0.4 5.1e-11 42.8 0.0 2.5 2 0 0 2 2 2 1 DUSP domain UCH_1 PF13423.1 KOO28495.1 - 1.1e-06 28.3 0.0 1.4e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ShK PF01549.19 KOO28497.1 - 5.7e-16 58.5 21.4 7.1e-09 35.8 6.2 2.4 2 0 0 2 2 2 2 ShK domain-like zf-CCCH PF00642.19 KOO28497.1 - 0.26 11.0 2.8 3.4 7.4 0.0 3.3 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Ion_trans PF00520.26 KOO28498.1 - 3.4e-13 49.3 3.4 5.3e-13 48.6 2.3 1.3 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO28498.1 - 0.21 11.3 4.7 0.54 10.0 3.3 1.8 1 1 0 1 1 1 0 Ion channel Polysacc_deac_1 PF01522.16 KOO28500.1 - 9.1e-17 60.8 0.0 1.4e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase 2OG-FeII_Oxy PF03171.15 KOO28500.1 - 0.0055 16.9 0.1 0.0093 16.2 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Fer2_4 PF13510.1 KOO28500.1 - 0.031 14.0 0.1 0.063 13.0 0.0 1.5 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Ras PF00071.17 KOO28501.1 - 1.2e-14 54.0 0.1 1e-11 44.5 0.0 2.1 1 1 1 2 2 2 2 Ras family Miro PF08477.8 KOO28501.1 - 0.013 15.9 0.0 0.58 10.6 0.0 2.4 1 1 1 2 2 2 0 Miro-like protein DUF908 PF06012.7 KOO28501.1 - 0.019 14.2 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) adh_short PF00106.20 KOO28502.1 - 9.2e-14 51.6 0.4 1.6e-13 50.9 0.1 1.5 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 KOO28502.1 - 6.4e-06 25.9 0.2 9.5e-06 25.3 0.2 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 KOO28502.1 - 5.3e-05 22.7 0.0 7.1e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 KOO28502.1 - 0.1 11.4 0.2 0.68 8.7 0.2 2.0 1 1 0 1 1 1 0 RmlD substrate binding domain HAD PF12710.2 KOO28503.1 - 0.044 13.9 0.1 0.054 13.6 0.1 1.1 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase HALZ PF02183.13 KOO28505.1 - 0.06 13.0 11.8 0.42 10.3 0.0 3.7 4 0 0 4 4 4 0 Homeobox associated leucine zipper FH2 PF02181.18 KOO28505.1 - 0.33 9.7 7.3 0.077 11.8 1.2 1.9 1 1 1 2 2 2 0 Formin Homology 2 Domain FliE PF02049.13 KOO28505.1 - 0.64 10.0 6.6 0.27 11.2 2.1 2.1 2 1 0 2 2 2 0 Flagellar hook-basal body complex protein FliE DUF4201 PF13870.1 KOO28505.1 - 0.78 9.1 13.8 1.9 7.9 2.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DUF972 PF06156.8 KOO28505.1 - 1.1 9.5 13.5 1.5 9.1 1.1 3.4 1 1 1 3 3 3 0 Protein of unknown function (DUF972) DUF342 PF03961.8 KOO28505.1 - 1.4 7.2 7.6 0.44 8.9 1.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF342) DP PF08781.5 KOO28505.1 - 2 8.0 4.8 0.5 10.0 0.3 2.1 2 1 0 2 2 2 0 Transcription factor DP DUF904 PF06005.7 KOO28505.1 - 2.2 8.6 14.7 0.21 11.8 0.6 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF904) DUF4140 PF13600.1 KOO28505.1 - 3.2 8.2 26.5 0.06 13.8 1.5 3.4 2 2 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) Atg14 PF10186.4 KOO28505.1 - 5.5 5.8 20.4 0.46 9.3 6.6 2.1 1 1 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Vfa1 PF08432.5 KOO28505.1 - 6.9 6.6 7.8 7.1 6.6 3.8 2.0 1 1 1 2 2 2 0 AAA-ATPase Vps4-associated protein 1 MCC-bdg_PDZ PF10506.4 KOO28505.1 - 7.1 6.5 23.1 0.07 12.9 2.5 3.3 2 2 1 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Nuc_sug_transp PF04142.10 KOO28506.1 - 2.8e-24 85.5 4.4 4.8e-24 84.7 3.1 1.3 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.6 KOO28506.1 - 6.6e-05 21.9 4.8 6.6e-05 21.9 3.3 2.1 1 1 1 2 2 2 1 UAA transporter family EamA PF00892.15 KOO28506.1 - 0.00013 21.9 2.7 0.00013 21.9 1.9 2.9 3 1 0 3 3 3 1 EamA-like transporter family TPT PF03151.11 KOO28506.1 - 0.0017 18.0 4.6 0.0017 18.0 3.2 2.0 2 1 0 2 2 2 1 Triose-phosphate Transporter family EmrE PF13536.1 KOO28506.1 - 0.0027 17.9 0.7 0.0027 17.9 0.5 3.0 3 1 1 4 4 4 1 Multidrug resistance efflux transporter Transmemb_17 PF09799.4 KOO28506.1 - 0.41 10.9 10.2 0.059 13.7 1.9 2.8 3 0 0 3 3 3 0 Predicted membrane protein Phage_holin_5 PF06946.6 KOO28506.1 - 0.79 9.9 4.4 1.6 8.9 0.2 2.9 2 1 0 3 3 3 0 Phage holin ATP-sulfurylase PF01747.12 KOO28507.1 - 3.3e-59 199.8 0.0 6.3e-59 198.8 0.0 1.4 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.1 KOO28507.1 - 1e-40 138.7 0.0 1.5e-40 138.2 0.0 1.2 1 0 0 1 1 1 1 PUA-like domain 2OG-FeII_Oxy_3 PF13640.1 KOO28508.1 - 0.096 13.2 0.3 0.18 12.3 0.2 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DUF2968 PF11180.3 KOO28509.1 - 0.04 13.2 11.5 0.048 13.0 7.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) DUF4019 PF13211.1 KOO28509.1 - 0.4 10.9 3.8 0.95 9.7 2.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4019) DUF3708 PF12501.3 KOO28509.1 - 1.7 8.4 7.1 2 8.2 4.9 1.1 1 0 0 1 1 1 0 Phosphate ATP-binding cassette transporter KfrA_N PF11740.3 KOO28509.1 - 3.2 8.2 23.5 6.3 7.2 13.3 2.0 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term LPP PF04728.8 KOO28509.1 - 7.1 6.5 10.2 1.7 8.4 1.2 2.3 2 0 0 2 2 2 0 Lipoprotein leucine-zipper DUF2475 PF10629.4 KOO28510.1 - 3.9 7.8 9.5 11 6.3 0.0 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF2475) AAA_11 PF13086.1 KOO28512.1 - 2.9e-29 102.3 0.0 5.5e-29 101.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.1 KOO28512.1 - 4e-25 88.3 0.0 8.8e-25 87.2 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KOO28512.1 - 3.2e-09 36.4 0.0 1.2e-08 34.5 0.0 2.1 1 0 0 1 1 1 1 Part of AAA domain AAA_30 PF13604.1 KOO28512.1 - 2.8e-08 33.5 0.0 0.00036 20.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain UvrD-helicase PF00580.16 KOO28512.1 - 0.0046 16.2 0.0 0.0079 15.5 0.0 1.3 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain Parvo_NS1 PF01057.12 KOO28512.1 - 0.0054 15.6 0.0 0.009 14.9 0.0 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 PhoH PF02562.11 KOO28512.1 - 0.0077 15.4 0.0 0.015 14.5 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein AAA_25 PF13481.1 KOO28512.1 - 0.015 14.7 0.0 0.046 13.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain DEAD PF00270.24 KOO28512.1 - 0.022 14.2 0.0 0.082 12.3 0.0 1.9 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA PF00004.24 KOO28512.1 - 0.023 14.9 0.0 0.048 13.8 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOO28512.1 - 0.041 14.0 0.0 0.22 11.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.4 KOO28512.1 - 0.067 12.1 0.9 0.12 11.3 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) UvrD_C_2 PF13538.1 KOO28512.1 - 0.11 12.6 0.1 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain ResIII PF04851.10 KOO28512.1 - 0.2 11.4 0.0 0.35 10.6 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit PDZ PF00595.19 KOO28513.1 - 3.1e-08 33.6 0.0 4.9e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) LRR_4 PF12799.2 KOO28514.1 - 1.9e-11 43.2 10.6 3.3e-06 26.5 0.6 2.6 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO28514.1 - 1.2e-07 30.7 4.0 0.04 13.9 0.0 4.0 4 0 0 4 4 4 3 Leucine Rich Repeat LRR_8 PF13855.1 KOO28514.1 - 1.4e-07 31.1 9.1 2.2e-05 24.0 1.1 1.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_6 PF13516.1 KOO28514.1 - 2.9e-06 26.7 0.1 0.058 13.4 0.0 3.5 3 0 0 3 3 3 2 Leucine Rich repeat LRR_7 PF13504.1 KOO28514.1 - 0.00014 21.5 2.5 5.3 7.6 0.0 4.5 4 0 0 4 4 4 1 Leucine rich repeat DUF4379 PF14311.1 KOO28515.1 - 0.082 12.7 0.1 0.082 12.7 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4379) Herpes_capsid PF06112.6 KOO28515.1 - 0.29 11.1 2.8 0.47 10.4 1.9 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein THF_DHG_CYH_C PF02882.14 KOO28517.1 - 4.8e-67 224.0 3.5 4.8e-67 224.0 2.4 1.8 3 0 0 3 3 3 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.18 KOO28517.1 - 2.9e-41 140.1 0.3 4.8e-41 139.4 0.2 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain OCD_Mu_crystall PF02423.10 KOO28517.1 - 0.025 13.3 0.8 0.041 12.6 0.1 1.6 2 0 0 2 2 2 0 Ornithine cyclodeaminase/mu-crystallin family Gal_Lectin PF02140.13 KOO28518.1 - 3.7e-12 46.3 0.9 3.7e-12 46.3 0.7 1.8 2 0 0 2 2 2 1 Galactose binding lectin domain Thioredox_DsbH PF03190.10 KOO28518.1 - 0.035 13.8 0.0 0.097 12.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Beta-lactamase PF00144.19 KOO28519.1 - 1.8e-25 89.7 1.6 2.4e-25 89.2 1.1 1.1 1 0 0 1 1 1 1 Beta-lactamase PUB PF09409.5 KOO28520.1 - 2.3e-12 46.5 0.0 4e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 PUB domain DUF2379 PF09543.5 KOO28520.1 - 0.011 15.7 0.8 0.029 14.3 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2379) DnaJ PF00226.26 KOO28522.1 - 1.9e-20 72.3 0.1 1.9e-20 72.3 0.1 2.2 3 0 0 3 3 3 1 DnaJ domain FHA PF00498.21 KOO28523.1 - 7.1e-13 48.4 0.0 1.4e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 FHA domain Drf_FH3 PF06367.11 KOO28523.1 - 0.022 14.1 0.9 0.059 12.7 0.6 1.6 1 0 0 1 1 1 0 Diaphanous FH3 Domain IncA PF04156.9 KOO28523.1 - 2.7 7.5 56.7 1 8.9 9.4 3.1 1 1 2 3 3 3 0 IncA protein XhlA PF10779.4 KOO28523.1 - 9 6.2 10.8 1.4 8.9 2.3 3.2 1 1 1 2 2 2 0 Haemolysin XhlA DUF608 PF04685.8 KOO28524.1 - 2.5e-28 98.8 0.5 4.2e-28 98.1 0.4 1.3 1 1 0 1 1 1 1 Protein of unknown function, DUF608 GBA2_N PF12215.3 KOO28524.1 - 2.6e-15 56.3 0.0 1.3e-09 37.6 0.0 2.2 2 0 0 2 2 2 2 beta-Glucocerebrosidase 2 N terminal PAN_4 PF14295.1 KOO28524.1 - 0.019 14.6 3.2 0.05 13.3 2.2 1.7 1 0 0 1 1 1 0 PAN domain Saccharop_dh PF03435.13 KOO28525.1 - 1.7e-105 353.1 0.0 1.9e-105 353.0 0.0 1.0 1 0 0 1 1 1 1 Saccharopine dehydrogenase Death PF00531.17 KOO28525.1 - 0.041 13.6 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 Death domain LicD PF04991.8 KOO28526.1 - 2.1e-06 28.0 0.0 5e-06 26.7 0.0 1.6 2 0 0 2 2 2 1 LicD family DUF1295 PF06966.7 KOO28527.1 - 6.7e-45 153.2 3.2 6.7e-45 153.2 2.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) DUF2781 PF10914.3 KOO28527.1 - 1.1e-13 51.2 13.2 1.1e-13 51.2 9.1 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF2781) ICMT PF04140.9 KOO28527.1 - 0.0044 17.2 0.1 0.02 15.0 0.1 2.2 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family NTP_transferase PF00483.18 KOO28528.1 - 3.4e-10 39.6 0.0 5.2e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.19 KOO28528.1 - 1.2e-05 24.5 6.5 0.00031 20.1 0.7 3.6 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.2 KOO28528.1 - 0.0077 16.3 1.6 0.015 15.4 1.1 1.6 1 1 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.7 KOO28528.1 - 0.14 10.6 0.8 0.22 10.0 0.5 1.2 1 0 0 1 1 1 0 L-fucokinase DUF4185 PF13810.1 KOO28529.1 - 1.4e-11 43.8 0.1 1.9e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4185) AP_endonuc_2 PF01261.19 KOO28530.1 - 0.011 15.0 0.0 0.021 14.1 0.0 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Orn_Arg_deC_N PF02784.11 KOO28530.1 - 0.19 10.8 0.0 0.28 10.3 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Glyco_hydro_3 PF00933.16 KOO28531.1 - 0.0015 17.5 0.0 0.0017 17.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain DUF515 PF04415.7 KOO28531.1 - 1.1 7.3 8.0 1.2 7.2 5.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Rgp1 PF08737.5 KOO28532.1 - 0.00086 18.4 0.1 0.00096 18.3 0.0 1.1 1 0 0 1 1 1 1 Rgp1 Cyclin PF08613.6 KOO28533.1 - 1.1e-19 71.2 0.1 1.8e-19 70.6 0.0 1.3 1 0 0 1 1 1 1 Cyclin Homeobox PF00046.24 KOO28533.1 - 5.2e-17 61.2 0.7 9.8e-17 60.3 0.5 1.5 1 0 0 1 1 1 1 Homeobox domain Cyclin_N PF00134.18 KOO28533.1 - 1.7e-05 24.4 0.0 2.7e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Homeobox_KN PF05920.6 KOO28533.1 - 0.09 12.4 0.2 0.21 11.3 0.1 1.6 1 0 0 1 1 1 0 Homeobox KN domain TRAM_LAG1_CLN8 PF03798.11 KOO28535.1 - 6.2e-20 71.5 12.7 6.2e-20 71.5 8.8 1.4 2 0 0 2 2 2 1 TLC domain TPR_2 PF07719.12 KOO28536.1 - 7.7e-19 66.0 3.9 0.00014 21.4 0.1 6.0 5 2 1 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.23 KOO28536.1 - 1.2e-17 62.6 0.5 0.003 17.0 0.0 5.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.1 KOO28536.1 - 5e-15 55.1 21.7 2.1e-06 27.5 0.1 3.8 1 1 2 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.1 KOO28536.1 - 7e-15 53.6 0.0 0.0002 20.8 0.0 5.4 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.1 KOO28536.1 - 2.2e-13 49.6 20.4 1.7e-06 27.5 1.4 4.0 1 1 4 5 5 5 5 TPR repeat TPR_7 PF13176.1 KOO28536.1 - 2.4e-10 39.4 11.4 0.23 11.3 0.1 5.6 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.1 KOO28536.1 - 1.3e-07 32.1 17.9 6.4e-05 23.4 0.1 4.3 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO28536.1 - 1.8e-07 30.8 1.1 0.6 10.4 0.0 5.2 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28536.1 - 8.1e-07 29.1 12.4 2.8 8.8 0.0 5.9 3 1 3 6 6 6 2 Tetratricopeptide repeat TPR_4 PF07721.9 KOO28536.1 - 6.1e-06 26.1 21.7 0.15 12.5 0.3 7.5 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.1 KOO28536.1 - 1.4e-05 24.8 13.2 0.0047 16.8 0.1 5.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.1 KOO28536.1 - 2.1e-05 24.6 1.2 0.57 10.7 0.0 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO28536.1 - 0.00016 21.9 5.1 0.17 12.2 0.4 4.1 2 2 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO28536.1 - 0.15 11.9 0.9 12 5.8 0.1 3.2 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Apc5 PF12862.2 KOO28536.1 - 0.21 11.4 3.5 0.21 11.4 0.6 2.3 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 5 DUF3856 PF12968.2 KOO28536.1 - 0.64 9.8 5.3 7.9 6.2 0.2 3.0 1 1 1 3 3 3 0 Domain of Unknown Function (DUF3856) TPR_9 PF13371.1 KOO28536.1 - 1.5 8.7 9.6 1.2 9.0 0.4 3.8 2 2 1 3 3 3 0 Tetratricopeptide repeat Glyco_tranf_2_3 PF13641.1 KOO28538.1 - 1.5e-24 87.0 0.0 2.1e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 KOO28538.1 - 5.7e-17 62.0 2.5 5.7e-17 62.0 1.8 1.8 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.1 KOO28538.1 - 1.6e-09 37.2 0.0 2.5e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 KOO28538.1 - 3.1e-07 30.2 0.0 5.1e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.4 KOO28538.1 - 0.0016 17.5 0.0 0.0042 16.2 0.0 1.6 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_29 PF00777.13 KOO28539.1 - 6.1e-28 97.7 0.0 1.3e-27 96.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) Hydrolase_like PF13242.1 KOO28539.1 - 7.1e-10 38.4 0.0 1.8e-09 37.1 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.1 KOO28539.1 - 6.1e-09 35.6 0.0 2.1e-08 33.9 0.0 1.9 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOO28539.1 - 0.019 15.3 0.0 6.9 7.0 0.0 2.7 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.5 KOO28539.1 - 0.16 11.3 0.0 0.28 10.5 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase Borrelia_P83 PF05262.6 KOO28540.1 - 0.013 13.7 4.1 0.013 13.7 2.8 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF2992 PF11208.3 KOO28540.1 - 7.1 6.5 9.4 9.6 6.1 6.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) Helicase_C PF00271.26 KOO28541.1 - 3e-08 33.4 0.0 5.9e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOO28541.1 - 0.00043 19.8 0.1 0.0013 18.3 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase CSTF_C PF14304.1 KOO28542.1 - 0.0015 17.7 0.0 0.98 8.7 0.0 2.4 1 1 1 2 2 2 2 Transcription termination and cleavage factor C-terminal Mito_fiss_reg PF05308.6 KOO28542.1 - 0.019 14.3 0.2 0.025 13.9 0.2 1.3 1 1 0 1 1 1 0 Mitochondrial fission regulator DUF484 PF04340.7 KOO28542.1 - 0.029 13.8 0.1 0.032 13.7 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function, DUF484 peroxidase PF00141.18 KOO28542.1 - 0.032 13.7 0.1 0.04 13.3 0.1 1.2 1 0 0 1 1 1 0 Peroxidase Nuc_sug_transp PF04142.10 KOO28543.1 - 5e-54 182.9 4.7 7.9e-54 182.3 3.2 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.6 KOO28543.1 - 8.6e-07 28.1 9.7 1.5e-06 27.4 6.7 1.4 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.15 KOO28543.1 - 2.1e-06 27.7 6.6 2.1e-06 27.7 4.6 2.7 2 1 0 2 2 2 1 EamA-like transporter family EmrE PF13536.1 KOO28543.1 - 4.6e-06 26.8 23.9 6.8e-06 26.2 3.3 3.0 2 1 1 3 3 3 2 Multidrug resistance efflux transporter TPT PF03151.11 KOO28543.1 - 0.024 14.2 22.6 0.03 13.9 5.9 2.9 2 2 0 2 2 2 0 Triose-phosphate Transporter family Helicase_C_2 PF13307.1 KOO28545.1 - 5.6e-39 133.7 0.0 1.2e-36 126.1 0.0 2.6 1 1 1 2 2 2 2 Helicase C-terminal domain DEAD_2 PF06733.10 KOO28545.1 - 5.6e-34 117.0 0.0 9.7e-34 116.2 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 RRM_1 PF00076.17 KOO28545.1 - 6.8e-07 28.8 0.0 1.4e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO28545.1 - 2e-05 24.3 0.0 4.1e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO28545.1 - 0.0034 17.3 0.0 0.01 15.8 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DEAD PF00270.24 KOO28545.1 - 0.011 15.2 0.0 3.3 7.1 0.0 2.5 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_22 PF13401.1 KOO28545.1 - 0.022 14.8 0.1 8.2 6.5 0.1 3.0 2 1 0 2 2 2 0 AAA domain ResIII PF04851.10 KOO28545.1 - 0.096 12.5 0.0 12 5.6 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit PhoH PF02562.11 KOO28545.1 - 0.12 11.5 0.0 11 5.1 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein DUF2315 PF10231.4 KOO28545.1 - 0.23 11.3 0.3 0.43 10.4 0.2 1.4 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2315) DAGAT PF03982.8 KOO28546.1 - 2e-18 66.1 0.0 2.8e-18 65.6 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Ank_2 PF12796.2 KOO28547.1 - 7.9e-22 77.4 0.7 2.5e-11 43.7 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO28547.1 - 1.3e-18 65.7 4.2 4.5e-05 23.0 0.1 5.1 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.1 KOO28547.1 - 1.2e-16 60.3 2.2 2.1e-07 30.9 0.2 4.2 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO28547.1 - 4.9e-16 57.2 0.1 0.00071 19.5 0.0 4.6 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.1 KOO28547.1 - 5.3e-14 52.2 0.4 1e-05 25.8 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) 2OG-FeII_Oxy_3 PF13640.1 KOO28547.1 - 0.0073 16.8 0.1 0.02 15.3 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF45 PF01863.12 KOO28547.1 - 0.011 15.5 0.1 0.016 14.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF45 2OG-FeII_Oxy PF03171.15 KOO28547.1 - 0.047 13.9 2.1 0.66 10.3 0.3 2.6 2 1 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily MatE PF01554.13 KOO28548.1 - 4.6e-30 104.3 13.9 1.9e-17 63.3 1.3 2.1 2 0 0 2 2 2 2 MatE DUF4349 PF14257.1 KOO28549.1 - 0.16 11.1 4.1 0.25 10.5 2.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) ATG16 PF08614.6 KOO28549.1 - 0.32 10.8 14.0 0.83 9.4 7.5 2.5 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF87 PF01935.12 KOO28549.1 - 0.75 9.5 3.0 0.93 9.2 1.7 1.5 1 1 1 2 2 2 0 Domain of unknown function DUF87 Rab5-bind PF09311.6 KOO28549.1 - 0.94 9.3 13.4 7.6 6.3 6.2 2.1 2 0 0 2 2 2 0 Rabaptin-like protein CDO_I PF05995.7 KOO28549.1 - 2.6 7.1 5.3 5.3 6.1 0.2 2.8 2 1 1 3 3 3 0 Cysteine dioxygenase type I Histone_HNS PF00816.16 KOO28549.1 - 7.5 7.1 7.0 2.4 8.7 1.9 2.4 1 1 1 2 2 2 0 H-NS histone family TIM PF00121.13 KOO28550.1 - 3.2e-68 229.4 0.0 3.7e-68 229.2 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase Fusion_gly PF00523.13 KOO28550.1 - 0.15 10.0 0.5 0.21 9.6 0.3 1.1 1 0 0 1 1 1 0 Fusion glycoprotein F0 GST_N_3 PF13417.1 KOO28551.1 - 2.1e-19 69.5 0.0 5.3e-19 68.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 KOO28551.1 - 6.4e-14 51.7 0.1 1.1e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.20 KOO28551.1 - 7.2e-08 32.3 0.0 1.2e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 KOO28551.1 - 9.4e-05 22.2 0.2 0.00021 21.1 0.1 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 KOO28551.1 - 0.00049 20.5 0.0 0.001 19.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.19 KOO28551.1 - 0.0014 18.5 0.0 0.003 17.5 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin PGK PF00162.14 KOO28553.1 - 1.3e-142 474.9 0.7 1.5e-142 474.7 0.5 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase TMP-TENI PF02581.12 KOO28553.1 - 0.04 13.0 0.1 1.8 7.6 0.0 2.4 2 0 0 2 2 2 0 Thiamine monophosphate synthase/TENI Nitro_FeMo-Co PF02579.12 KOO28553.1 - 0.19 11.7 2.0 8.3 6.5 0.1 3.4 4 0 0 4 4 4 0 Dinitrogenase iron-molybdenum cofactor Pkinase PF00069.20 KOO28554.1 - 1.8e-31 109.2 0.0 1.1e-20 73.8 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO28554.1 - 3.5e-18 65.5 0.0 5.8e-12 45.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 KOO28554.1 - 0.00083 19.1 1.2 0.0092 15.7 0.0 2.4 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.9 KOO28554.1 - 0.009 15.1 0.0 0.014 14.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 KOO28554.1 - 0.011 14.7 0.0 0.027 13.4 0.0 1.6 2 0 0 2 2 2 0 Kinase-like Ank_2 PF12796.2 KOO28555.1 - 2.4e-39 133.5 11.6 3.9e-20 71.9 1.6 4.6 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 KOO28555.1 - 1.6e-32 109.7 14.7 6.8e-08 31.9 0.1 7.5 8 0 0 8 8 8 5 Ankyrin repeat Ank_4 PF13637.1 KOO28555.1 - 6.9e-30 102.8 9.2 4.1e-10 39.8 0.1 5.2 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO28555.1 - 4.2e-20 69.8 4.9 0.00012 21.9 0.1 7.6 8 0 0 8 8 8 5 Ankyrin repeat Ank_5 PF13857.1 KOO28555.1 - 3.8e-18 65.0 13.3 1.3e-06 28.4 1.2 7.0 3 1 4 7 7 7 5 Ankyrin repeats (many copies) DUF2946 PF11162.3 KOO28556.1 - 0.069 13.3 0.9 0.6 10.3 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2946) SNF2_N PF00176.18 KOO28558.1 - 1.3e-73 247.4 0.5 2.2e-73 246.7 0.3 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain HSA PF07529.8 KOO28558.1 - 3.3e-18 65.2 9.0 1.3e-17 63.3 5.5 2.6 1 1 1 2 2 2 1 HSA Helicase_C PF00271.26 KOO28558.1 - 4.9e-16 58.3 0.0 1.5e-15 56.7 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO28558.1 - 6.5e-12 45.6 0.0 1.4e-11 44.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-CXXC PF02008.15 KOO28558.1 - 2.3e-11 43.3 8.3 4.2e-05 23.2 1.5 2.5 2 0 0 2 2 2 2 CXXC zinc finger domain DEAD PF00270.24 KOO28558.1 - 8.9e-07 28.5 0.0 3.6e-06 26.5 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase HDA2-3 PF11496.3 KOO28558.1 - 0.022 13.5 0.0 2.2 7.0 0.0 2.9 2 1 0 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 FbpA PF05833.6 KOO28559.1 - 2.6e-43 148.2 0.0 2.6e-43 148.2 0.0 2.3 2 1 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) DUF3441 PF11923.3 KOO28559.1 - 4.2e-24 84.3 0.0 4.2e-24 84.3 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF3441) DUF814 PF05670.8 KOO28559.1 - 1.1e-13 50.8 0.0 4.6e-13 48.8 0.0 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF814) PKD_channel PF08016.7 KOO28560.1 - 1.1e-07 30.6 13.0 1.1e-07 30.6 9.0 1.6 1 1 1 2 2 2 1 Polycystin cation channel OAD_gamma PF04277.8 KOO28560.1 - 0.17 12.2 0.1 0.17 12.2 0.1 3.1 4 0 0 4 4 4 0 Oxaloacetate decarboxylase, gamma chain HsdM_N PF12161.3 KOO28560.1 - 0.52 10.7 3.8 0.66 10.3 0.3 2.5 2 0 0 2 2 2 0 HsdM N-terminal domain Ion_trans PF00520.26 KOO28560.1 - 6.2 6.0 17.7 1.9 7.7 9.8 1.9 2 0 0 2 2 2 0 Ion transport protein Ank_2 PF12796.2 KOO28562.1 - 5.7e-19 68.2 2.6 4.9e-11 42.8 0.2 2.7 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO28562.1 - 7.4e-17 60.2 4.6 1.4e-05 24.6 0.2 3.9 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 KOO28562.1 - 2e-14 53.2 6.7 5.6e-05 23.2 0.1 3.9 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO28562.1 - 8.7e-13 47.1 0.7 0.0018 18.2 0.1 3.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 KOO28562.1 - 2.1e-10 40.8 0.3 2.3e-07 31.1 0.0 2.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Lipase_GDSL_2 PF13472.1 KOO28563.1 - 0.022 14.9 0.0 0.05 13.7 0.0 1.7 1 1 1 2 2 2 0 GDSL-like Lipase/Acylhydrolase family ABC1 PF03109.11 KOO28564.1 - 2.3e-21 75.9 0.0 6.9e-21 74.4 0.0 1.9 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 KOO28564.1 - 3.1e-06 27.1 6.9 3.8e-06 26.8 1.6 3.2 2 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.20 KOO28564.1 - 0.096 11.8 0.0 0.98 8.5 0.0 2.1 2 0 0 2 2 2 0 Protein kinase domain EF-hand_6 PF13405.1 KOO28565.1 - 7.7e-12 44.0 0.5 0.00053 19.6 0.0 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO28565.1 - 1.1e-09 38.2 0.2 6.6e-08 32.5 0.0 3.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO28565.1 - 1.9e-09 36.1 3.1 0.00012 21.1 0.0 3.6 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.1 KOO28565.1 - 5.9e-08 32.2 0.3 2.6e-06 26.9 0.0 2.6 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO28565.1 - 0.00075 18.7 10.0 0.011 14.9 0.1 3.9 4 0 0 4 4 4 2 EF hand ACT_6 PF13740.1 KOO28565.1 - 0.11 12.2 1.4 16 5.2 0.0 3.9 3 0 0 3 3 3 0 ACT domain DUF4579 PF15158.1 KOO28565.1 - 0.7 9.3 4.8 2.8 7.4 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4579) MtrG PF04210.8 KOO28565.1 - 1.5 8.5 4.8 6.7 6.4 0.2 3.3 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G IFT57 PF10498.4 KOO28566.1 - 0.00025 19.9 13.4 0.0011 17.7 5.0 2.4 1 1 1 2 2 2 2 Intra-flagellar transport protein 57 Bacillus_HBL PF05791.6 KOO28566.1 - 0.0065 15.8 0.5 0.0065 15.8 0.3 2.5 2 0 0 2 2 2 1 Bacillus haemolytic enterotoxin (HBL) Reo_sigmaC PF04582.7 KOO28566.1 - 0.071 12.2 9.2 1.9 7.6 3.4 2.6 2 0 0 2 2 2 0 Reovirus sigma C capsid protein RBD-FIP PF09457.5 KOO28566.1 - 0.17 11.6 4.3 6 6.7 0.4 3.0 2 0 0 2 2 2 0 FIP domain Spc7 PF08317.6 KOO28566.1 - 0.19 10.3 17.5 0.33 9.5 1.1 3.1 3 0 0 3 3 3 0 Spc7 kinetochore protein AbiH PF14253.1 KOO28566.1 - 0.33 10.5 5.4 1.5 8.3 3.8 1.9 1 1 0 1 1 1 0 Bacteriophage abortive infection AbiH DUF948 PF06103.6 KOO28566.1 - 0.38 10.6 6.3 0.25 11.2 0.3 3.0 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Cauli_AT PF03233.8 KOO28566.1 - 0.52 9.9 3.9 6.4 6.4 0.1 2.4 2 0 0 2 2 2 0 Aphid transmission protein Fib_alpha PF08702.5 KOO28566.1 - 4.6 7.3 6.4 6.8 6.8 0.5 2.9 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Prefoldin PF02996.12 KOO28566.1 - 5.8 6.6 17.0 0.44 10.2 1.0 4.0 4 0 0 4 4 4 0 Prefoldin subunit DUF4537 PF15057.1 KOO28567.1 - 1.3e-07 31.4 0.0 4.3e-07 29.7 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4537) 53-BP1_Tudor PF09038.5 KOO28567.1 - 1.3e-05 24.9 0.7 0.00014 21.6 0.1 2.3 1 1 1 2 2 2 1 Tumour suppressor p53-binding protein-1 Tudor DUF1325 PF07039.6 KOO28567.1 - 0.015 14.9 0.0 0.039 13.5 0.0 1.6 1 1 0 1 1 1 0 SGF29 tudor-like domain KOW PF00467.24 KOO28567.1 - 0.048 13.4 0.0 0.17 11.6 0.0 2.0 1 0 0 1 1 1 0 KOW motif Ank_2 PF12796.2 KOO28568.1 - 9.1e-16 57.9 0.1 2.2e-15 56.7 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO28568.1 - 1.8e-15 55.8 0.4 2.3e-06 27.1 0.4 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 KOO28568.1 - 2e-08 34.5 0.3 2.5e-07 31.0 0.2 2.8 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO28568.1 - 4.1e-08 32.7 0.2 0.012 15.7 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 KOO28568.1 - 1.2e-06 28.5 0.4 5.3e-05 23.3 0.2 2.7 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ribonuclease_T2 PF00445.13 KOO28570.1 - 3.3e-11 43.1 0.0 4.9e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family Glyco_transf_25 PF01755.12 KOO28571.1 - 2.8e-26 92.4 0.0 6.6e-26 91.1 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) MMR_HSR1 PF01926.18 KOO28573.1 - 9.4e-20 70.7 0.0 1.3e-19 70.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KOO28573.1 - 1.5e-09 37.3 0.0 1.9e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 KOO28573.1 - 0.00051 19.8 0.0 0.0052 16.6 0.0 1.9 1 1 1 2 2 2 1 Dynamin family GTP_EFTU PF00009.22 KOO28573.1 - 0.00099 18.5 0.0 0.053 12.9 0.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 KOO28573.1 - 0.003 16.7 0.0 0.0046 16.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 KOO28573.1 - 0.021 14.3 0.0 0.04 13.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AIG1 PF04548.11 KOO28573.1 - 0.028 13.5 0.0 0.041 12.9 0.0 1.1 1 0 0 1 1 1 0 AIG1 family ABC_tran PF00005.22 KOO28573.1 - 0.057 13.7 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Miro PF08477.8 KOO28573.1 - 0.057 13.9 0.0 0.095 13.2 0.0 1.5 1 1 0 1 1 1 0 Miro-like protein AAA_21 PF13304.1 KOO28573.1 - 0.14 12.0 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Nol1_Nop2_Fmu PF01189.12 KOO28574.1 - 2.9e-29 102.3 0.7 4.8e-17 62.2 0.0 3.4 3 1 0 3 3 3 2 NOL1/NOP2/sun family Methyltransf_26 PF13659.1 KOO28574.1 - 0.017 15.1 1.7 0.026 14.5 0.1 2.1 2 0 0 2 2 2 0 Methyltransferase domain FtsJ PF01728.14 KOO28574.1 - 0.034 14.1 0.0 0.055 13.4 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase RCC1 PF00415.13 KOO28575.1 - 4.6e-16 58.7 1.2 1.5e-09 37.9 0.0 2.3 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO28575.1 - 1.8e-07 30.5 1.7 1.2e-05 24.7 0.3 2.7 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat NTR2 PF15458.1 KOO28576.1 - 0.0041 16.3 0.9 0.0041 16.3 0.7 1.6 1 1 1 2 2 2 1 Nineteen complex-related protein 2 CALCOCO1 PF07888.6 KOO28576.1 - 0.015 13.6 0.8 0.015 13.6 0.5 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like TMF_TATA_bd PF12325.3 KOO28576.1 - 0.035 13.8 5.0 0.069 12.8 3.2 1.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Linocin_M18 PF04454.7 KOO28576.1 - 0.18 10.6 4.9 0.14 11.0 1.1 1.9 2 0 0 2 2 2 0 Encapsulating protein for peroxidase Usp PF00582.21 KOO28576.1 - 0.26 11.4 5.4 0.6 10.2 3.6 1.7 1 1 0 1 1 1 0 Universal stress protein family M PF02370.11 KOO28576.1 - 3.1 8.4 5.6 2.5 8.7 0.5 2.8 2 0 0 2 2 2 0 M protein repeat DUF4140 PF13600.1 KOO28576.1 - 5.3 7.5 8.7 6.7 7.2 3.5 2.4 1 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) TPR_11 PF13414.1 KOO28577.1 - 5.3e-12 45.2 16.0 8.4e-07 28.5 1.1 3.3 4 0 0 4 4 4 2 TPR repeat TPR_1 PF00515.23 KOO28577.1 - 3.3e-10 39.1 7.3 0.00077 18.9 0.1 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO28577.1 - 1.8e-09 36.7 15.1 0.0014 18.4 0.7 4.6 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_9 PF13371.1 KOO28577.1 - 7.1e-07 28.9 11.9 4.2e-05 23.3 0.8 3.2 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO28577.1 - 2e-05 24.4 1.6 2e-05 24.4 1.1 4.3 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO28577.1 - 0.0017 18.0 9.9 0.87 9.5 0.1 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO28577.1 - 0.0048 16.9 8.1 1.3 9.4 0.2 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO28577.1 - 0.0062 17.1 4.3 0.0062 17.1 3.0 5.5 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28577.1 - 0.0068 16.9 2.0 0.0068 16.9 1.4 6.1 5 1 3 8 8 6 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO28577.1 - 0.013 15.2 1.0 8.9 6.3 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 KOO28577.1 - 0.51 10.3 0.1 0.51 10.3 0.1 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat Filamin PF00630.14 KOO28578.1 - 9.8e-20 71.0 0.0 2.3e-16 60.1 0.0 2.4 2 0 0 2 2 2 2 Filamin/ABP280 repeat Herpes_UL25 PF01499.11 KOO28578.1 - 6.8e-05 21.3 1.1 9.2e-05 20.9 0.8 1.1 1 0 0 1 1 1 1 Herpesvirus UL25 family RNA_pol_A_bac PF01000.21 KOO28580.1 - 1.7e-27 95.7 0.0 2.7e-27 95.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 KOO28580.1 - 1.3e-18 65.8 0.0 1.8e-18 65.3 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4_7 PF12838.2 KOO28580.1 - 0.066 13.6 1.2 0.15 12.4 0.9 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer2 PF00111.22 KOO28582.1 - 4.2e-10 39.2 0.5 7e-10 38.5 0.4 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Kinesin PF00225.18 KOO28584.1 - 2.8e-62 210.3 0.0 4.3e-62 209.7 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain zf-C3HC4_2 PF13923.1 KOO28584.1 - 8.8e-06 25.6 10.4 8.8e-06 25.6 7.2 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO28584.1 - 5e-05 22.8 8.4 5e-05 22.8 5.8 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.1 KOO28584.1 - 9.1e-05 22.1 5.8 0.00023 20.8 4.0 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.1 KOO28584.1 - 0.0012 18.5 7.7 0.0012 18.5 5.4 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.1 KOO28584.1 - 0.0018 18.0 10.7 0.0018 18.0 7.4 2.6 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.1 KOO28584.1 - 0.0026 17.4 11.2 0.0079 15.8 7.8 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 KOO28584.1 - 1.3 8.8 7.3 3.8 7.3 5.1 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-MIZ PF02891.15 KOO28584.1 - 3.8 7.1 10.7 12 5.4 7.4 1.9 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger EF-hand_1 PF00036.27 KOO28586.1 - 1.3e-08 33.5 0.1 4.1e-05 22.5 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO28586.1 - 1.5e-08 33.8 0.1 9.6e-05 21.9 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO28586.1 - 3.6e-06 26.0 0.4 0.00059 19.0 0.1 3.1 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO28586.1 - 8.4e-06 25.8 0.1 5.4e-05 23.2 0.0 2.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO28586.1 - 0.00077 19.0 0.1 0.0048 16.4 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair Reo_sigmaC PF04582.7 KOO28586.1 - 0.36 9.9 5.8 9 5.3 0.3 3.3 3 0 0 3 3 3 0 Reovirus sigma C capsid protein Cluap1 PF10234.4 KOO28587.1 - 0.22 10.6 2.4 0.4 9.8 1.6 1.3 1 0 0 1 1 1 0 Clusterin-associated protein-1 SQS_PSY PF00494.14 KOO28588.1 - 0.13 11.5 7.1 0.66 9.2 1.8 2.7 1 1 0 2 2 2 0 Squalene/phytoene synthase Ank_2 PF12796.2 KOO28589.1 - 2.6e-12 46.8 2.1 8.6e-12 45.2 1.1 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO28589.1 - 5.7e-10 38.4 1.8 1.6e-05 24.4 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 KOO28589.1 - 2.7e-09 36.9 3.1 7.3e-08 32.4 0.5 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO28589.1 - 1.6e-08 34.8 0.3 3.5e-08 33.7 0.2 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO28589.1 - 7e-08 31.9 0.2 0.002 18.1 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat EF-hand_7 PF13499.1 KOO28590.1 - 2.4e-20 72.4 0.0 4.3e-08 33.1 0.0 4.0 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.27 KOO28590.1 - 7.3e-19 65.5 0.3 0.0021 17.2 0.0 5.4 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.1 KOO28590.1 - 8.2e-17 59.5 1.0 0.0011 18.6 0.0 5.6 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.1 KOO28590.1 - 4.1e-16 57.5 9.4 0.0057 15.9 0.0 5.7 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.1 KOO28590.1 - 9.8e-10 37.9 1.0 0.064 12.8 0.0 4.7 3 1 1 4 4 4 2 EF-hand domain pair VCBS PF13517.1 KOO28590.1 - 0.00099 19.4 4.1 0.8 10.1 0.2 3.5 3 0 0 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella SPARC_Ca_bdg PF10591.4 KOO28590.1 - 0.093 12.7 0.0 1 9.4 0.0 2.5 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region FG-GAP PF01839.18 KOO28590.1 - 0.4 10.4 15.1 2.5 7.8 0.3 3.7 3 0 0 3 3 3 0 FG-GAP repeat EF-hand_1 PF00036.27 KOO28592.1 - 9.9e-14 49.5 0.0 3.2e-06 26.0 0.0 3.7 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.1 KOO28592.1 - 5.3e-12 45.6 0.0 2e-05 24.6 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO28592.1 - 1.2e-11 43.4 0.0 2.1e-06 27.1 0.0 3.4 3 2 1 4 4 4 2 EF-hand domain EF-hand_5 PF13202.1 KOO28592.1 - 1.5e-09 36.7 0.0 2.5e-05 23.4 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO28592.1 - 1.4e-06 27.8 1.0 0.011 15.3 0.0 3.7 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_9 PF14658.1 KOO28592.1 - 8.7e-06 25.5 0.0 0.0029 17.4 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain UPF0154 PF03672.8 KOO28592.1 - 0.11 12.1 0.0 4.2 7.0 0.0 2.7 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0154) zf-C2H2_4 PF13894.1 KOO28593.1 - 0.21 12.0 2.6 0.27 11.6 1.0 1.9 2 0 0 2 2 2 0 C2H2-type zinc finger CDC45 PF02724.9 KOO28593.1 - 2.1 6.2 8.3 3.6 5.4 5.8 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF962 PF06127.6 KOO28596.1 - 0.7 9.8 15.6 6.2 6.7 0.0 5.3 4 2 0 4 4 4 0 Protein of unknown function (DUF962) Tom5 PF10642.4 KOO28596.1 - 1.7 8.3 7.8 12 5.5 0.0 4.1 4 0 0 4 4 4 0 Mitochondrial import receptor subunit or translocase LRR_6 PF13516.1 KOO28597.1 - 9.2e-24 80.8 6.1 0.025 14.6 0.0 8.4 8 1 0 8 8 8 6 Leucine Rich repeat LRR_4 PF12799.2 KOO28597.1 - 1.2e-10 40.7 3.2 0.0098 15.4 0.0 5.1 2 1 4 6 6 6 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO28597.1 - 6e-09 34.7 0.4 4.8 7.5 0.0 7.2 7 0 0 7 7 7 2 Leucine Rich Repeat LRR_7 PF13504.1 KOO28597.1 - 2.7e-06 26.6 3.6 38 5.1 0.0 6.6 7 0 0 7 7 7 0 Leucine rich repeat LRR_8 PF13855.1 KOO28597.1 - 0.0033 17.1 10.2 3 7.6 0.3 5.4 3 2 2 6 6 6 3 Leucine rich repeat adh_short PF00106.20 KOO28599.1 - 2.7e-24 85.9 11.3 4.7e-24 85.1 7.8 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KOO28599.1 - 8.1e-12 45.4 1.4 1.2e-11 44.8 1.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KOO28599.1 - 8.1e-11 41.9 6.7 1.5e-10 40.9 4.7 1.4 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 KOO28599.1 - 6e-05 23.1 1.9 0.00014 21.9 1.3 1.6 1 1 0 1 1 1 1 NADH(P)-binding Eno-Rase_NADH_b PF12242.3 KOO28599.1 - 0.082 12.7 0.6 0.23 11.2 0.4 1.8 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Epimerase PF01370.16 KOO28599.1 - 0.12 11.7 0.4 0.26 10.6 0.2 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family NB-ARC PF00931.17 KOO28600.1 - 6.6e-10 38.3 0.0 0.00047 19.1 0.0 2.4 2 1 0 2 2 2 2 NB-ARC domain RRM_1 PF00076.17 KOO28601.1 - 0.061 12.9 0.0 0.32 10.6 0.0 2.2 2 1 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UPF0278 PF08745.6 KOO28602.1 - 0.065 12.4 0.5 0.11 11.7 0.2 1.6 1 1 0 1 1 1 0 UPF0278 family DUF461 PF04314.8 KOO28602.1 - 0.092 12.4 0.1 0.19 11.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF461) TerB PF05099.8 KOO28602.1 - 1.1 9.0 13.9 3.5 7.3 9.6 1.8 1 1 0 1 1 1 0 Tellurite resistance protein TerB Complex1_LYR PF05347.10 KOO28602.1 - 8.8 6.2 8.2 1.4 8.7 0.3 3.0 2 2 1 3 3 3 0 Complex 1 protein (LYR family) UBA PF00627.26 KOO28603.1 - 0.013 15.3 0.0 0.039 13.8 0.0 1.8 1 0 0 1 1 1 0 UBA/TS-N domain Arm PF00514.18 KOO28606.1 - 2.4e-34 115.9 13.8 5.3e-09 35.5 0.1 7.3 7 0 0 7 7 7 7 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO28606.1 - 9.4e-05 22.6 15.3 0.17 12.2 4.5 3.6 1 1 2 4 4 4 4 HEAT repeats Atx10homo_assoc PF09759.4 KOO28606.1 - 0.0016 18.1 0.1 2.4 7.9 0.0 4.1 4 1 0 4 4 4 1 Spinocerebellar ataxia type 10 protein domain HEAT_PBS PF03130.11 KOO28606.1 - 0.032 14.7 6.4 18 6.1 0.6 4.6 4 1 0 4 4 4 0 PBS lyase HEAT-like repeat DUF1129 PF06570.6 KOO28607.1 - 0.097 11.9 1.5 0.13 11.5 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Kinesin PF00225.18 KOO28608.1 - 2.1e-79 266.6 0.0 2.5e-79 266.4 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Acetyltransf_10 PF13673.1 KOO28609.1 - 0.047 13.8 0.0 0.074 13.1 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AAA_27 PF13514.1 KOO28609.1 - 0.086 10.5 0.3 0.096 10.3 0.2 1.0 1 0 0 1 1 1 0 AAA domain HAD_2 PF13419.1 KOO28611.1 - 0.00093 19.4 0.0 0.0035 17.5 0.0 2.0 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Acid_PPase PF12689.2 KOO28611.1 - 0.027 14.0 0.1 0.27 10.8 0.1 2.2 1 1 0 1 1 1 0 Acid Phosphatase NIF PF03031.13 KOO28611.1 - 0.04 13.5 0.0 0.42 10.2 0.0 2.0 2 0 0 2 2 2 0 NLI interacting factor-like phosphatase FAP PF07174.6 KOO28611.1 - 2.1 7.5 20.5 3.7 6.7 14.2 1.3 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) DivIC PF04977.10 KOO28612.1 - 0.0039 16.6 0.2 0.0063 15.9 0.2 1.3 1 0 0 1 1 1 1 Septum formation initiator HALZ PF02183.13 KOO28612.1 - 0.044 13.5 0.2 0.06 13.0 0.1 1.2 1 0 0 1 1 1 0 Homeobox associated leucine zipper TMF_DNA_bd PF12329.3 KOO28612.1 - 0.048 13.4 0.8 0.059 13.1 0.5 1.1 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Mto2_bdg PF12808.2 KOO28612.1 - 0.071 13.2 0.3 0.11 12.5 0.2 1.3 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region CMS1 PF14617.1 KOO28612.1 - 0.14 11.2 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Ank_2 PF12796.2 KOO28613.1 - 2.3e-30 104.7 4.2 4.6e-12 46.1 0.0 3.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO28613.1 - 1.4e-24 85.5 11.9 3.2e-09 36.7 0.1 5.4 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO28613.1 - 2.4e-23 82.0 1.6 3.3e-09 37.0 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO28613.1 - 5.1e-18 63.9 0.6 3.5e-05 23.3 0.0 5.5 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.1 KOO28613.1 - 3.5e-15 54.5 0.2 0.00041 20.3 0.0 5.7 6 0 0 6 6 6 2 Ankyrin repeat Bacteriocin_IIi PF11758.3 KOO28613.1 - 1 8.9 6.1 21 4.8 0.0 3.8 4 1 0 4 4 4 0 Aureocin-like type II bacteriocin DUF1843 PF08898.5 KOO28613.1 - 1.8 8.6 6.1 6.7 6.8 0.1 3.4 4 1 0 4 4 4 0 Domain of unknown function (DUF1843) Glyco_transf_64 PF09258.5 KOO28614.1 - 0.00035 19.8 0.0 0.00069 18.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Radical_SAM PF04055.16 KOO28614.1 - 0.062 13.4 0.2 0.25 11.4 0.0 2.1 2 0 0 2 2 2 0 Radical SAM superfamily Fer4_14 PF13394.1 KOO28614.1 - 0.072 13.1 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 4Fe-4S single cluster domain Fer4_12 PF13353.1 KOO28614.1 - 0.081 13.0 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 4Fe-4S single cluster domain ShK PF01549.19 KOO28614.1 - 2.1 8.7 8.7 1.1 9.7 3.2 2.5 2 1 0 2 2 2 0 ShK domain-like Methyltransf_26 PF13659.1 KOO28615.1 - 2.9e-10 40.1 1.3 7.9e-10 38.7 0.2 2.3 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO28615.1 - 9.4e-10 39.0 0.0 2.8e-09 37.5 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 KOO28615.1 - 3.4e-06 26.4 0.0 6.3e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 KOO28615.1 - 3.2e-05 23.3 0.6 0.00011 21.6 0.1 2.1 2 0 0 2 2 2 1 Methyltransferase small domain Cons_hypoth95 PF03602.10 KOO28615.1 - 7.4e-05 22.2 0.0 0.00016 21.1 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 PCMT PF01135.14 KOO28615.1 - 0.00038 20.0 0.0 0.00076 19.0 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 KOO28615.1 - 0.00075 19.1 0.0 0.0014 18.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 KOO28615.1 - 0.0018 17.7 0.0 0.0032 16.9 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_11 PF08241.7 KOO28615.1 - 0.0025 18.2 0.0 0.007 16.8 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 KOO28615.1 - 0.0031 17.1 0.0 0.0051 16.4 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_32 PF13679.1 KOO28615.1 - 0.0068 16.0 0.2 0.034 13.8 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase domain RrnaAD PF00398.15 KOO28615.1 - 0.01 14.8 0.0 0.017 14.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase CMAS PF02353.15 KOO28615.1 - 0.012 14.7 0.0 0.019 14.0 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.1 KOO28615.1 - 0.014 15.7 0.0 0.04 14.2 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 KOO28615.1 - 0.074 12.7 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain LRR_6 PF13516.1 KOO28616.1 - 2.5e-07 30.0 11.3 0.27 11.4 0.0 5.7 6 0 0 6 6 6 3 Leucine Rich repeat LRR_7 PF13504.1 KOO28616.1 - 1.5e-05 24.4 1.1 8.6 7.0 0.2 4.9 4 0 0 4 4 4 2 Leucine rich repeat LRR_4 PF12799.2 KOO28616.1 - 3.4e-05 23.3 0.0 0.39 10.3 0.0 3.8 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO28616.1 - 0.00027 20.6 0.3 3.4 7.4 0.0 4.0 2 1 1 3 3 3 1 Leucine rich repeat LRR_1 PF00560.28 KOO28616.1 - 0.00059 19.5 0.9 20 5.7 0.0 4.9 5 0 0 5 5 5 1 Leucine Rich Repeat Period_C PF12114.3 KOO28618.1 - 1.3 8.6 4.3 2 8.0 3.0 1.3 1 0 0 1 1 1 0 Period protein 2/3C-terminal region Cript PF10235.4 KOO28622.1 - 7.2e-17 61.5 4.0 7.2e-17 61.5 2.8 1.8 2 0 0 2 2 2 1 Microtubule-associated protein CRIPT Tyr-DNA_phospho PF06087.7 KOO28622.1 - 0.13 10.9 0.0 0.15 10.6 0.0 1.1 1 0 0 1 1 1 0 Tyrosyl-DNA phosphodiesterase Acyltransferase PF01553.16 KOO28623.1 - 1e-08 34.7 0.0 2.3e-08 33.5 0.0 1.5 1 1 0 1 1 1 1 Acyltransferase Bromodomain PF00439.20 KOO28624.1 - 1e-45 153.5 0.0 2.8e-22 78.4 0.0 2.2 2 0 0 2 2 2 2 Bromodomain HALZ PF02183.13 KOO28625.1 - 0.033 13.9 0.5 0.033 13.9 0.4 3.0 4 0 0 4 4 4 0 Homeobox associated leucine zipper DUF3584 PF12128.3 KOO28625.1 - 0.22 8.8 22.0 0.01 13.2 5.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) V_ATPase_I PF01496.14 KOO28625.1 - 0.34 8.7 0.4 0.55 8.0 0.3 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CCDC-167 PF15188.1 KOO28625.1 - 0.64 10.0 6.5 2.3 8.1 0.7 3.0 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 IncA PF04156.9 KOO28625.1 - 1.7 8.2 13.8 0.07 12.7 4.0 2.2 2 0 0 2 2 2 0 IncA protein OmpH PF03938.9 KOO28625.1 - 2.6 7.9 19.5 2 8.3 7.0 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) AAA PF00004.24 KOO28626.1 - 6.5e-17 61.9 0.0 1.1e-16 61.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO28626.1 - 0.00014 21.8 0.1 0.00034 20.6 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 KOO28626.1 - 0.00044 21.0 0.0 0.00085 20.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOO28626.1 - 0.00062 18.9 0.0 0.001 18.1 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.1 KOO28626.1 - 0.0017 18.5 0.0 0.0037 17.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 KOO28626.1 - 0.0039 17.1 0.0 0.0071 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 KOO28626.1 - 0.0051 16.5 0.1 0.03 14.0 0.0 2.1 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) Miro PF08477.8 KOO28626.1 - 0.008 16.6 0.0 0.015 15.8 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein Viral_helicase1 PF01443.13 KOO28626.1 - 0.0093 15.5 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.1 KOO28626.1 - 0.0095 15.6 0.0 0.027 14.1 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_25 PF13481.1 KOO28626.1 - 0.011 15.1 0.2 0.04 13.3 0.0 1.8 1 1 0 2 2 2 0 AAA domain UPF0079 PF02367.12 KOO28626.1 - 0.015 14.9 0.0 0.039 13.5 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 MMR_HSR1 PF01926.18 KOO28626.1 - 0.017 15.0 0.0 0.029 14.3 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.1 KOO28626.1 - 0.02 15.2 0.0 0.035 14.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain DUF815 PF05673.8 KOO28626.1 - 0.036 12.9 0.1 0.089 11.7 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF815) ABC_tran PF00005.22 KOO28626.1 - 0.039 14.2 0.0 0.064 13.5 0.0 1.4 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.7 KOO28626.1 - 0.044 13.4 0.0 0.078 12.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_33 PF13671.1 KOO28626.1 - 0.044 13.6 0.0 0.063 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 KOO28626.1 - 0.052 13.0 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain KaiC PF06745.8 KOO28626.1 - 0.12 11.4 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 KaiC PDZ PF00595.19 KOO28627.1 - 4.1e-05 23.6 0.5 6.4e-05 23.0 0.4 1.2 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO28627.1 - 0.00014 21.7 0.3 0.0002 21.2 0.2 1.2 1 0 0 1 1 1 1 PDZ domain NHL PF01436.16 KOO28629.1 - 9.1e-07 28.5 1.2 0.086 12.8 0.0 3.7 4 0 0 4 4 4 2 NHL repeat PQQ_3 PF13570.1 KOO28629.1 - 0.03 14.6 1.6 6 7.2 0.0 2.9 2 0 0 2 2 2 0 PQQ-like domain HATPase_c_3 PF13589.1 KOO28630.1 - 0.00079 19.0 0.0 0.0015 18.2 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SAP PF02037.22 KOO28630.1 - 0.0034 16.8 0.4 0.022 14.2 0.0 2.6 2 0 0 2 2 2 1 SAP domain DUF3895 PF13034.1 KOO28630.1 - 0.048 13.1 0.2 2.6 7.5 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3895) Dynamin_N PF00350.18 KOO28631.1 - 4.3e-21 75.4 0.0 1.1e-20 74.1 0.0 1.7 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 KOO28631.1 - 1.9e-08 34.2 0.0 4.7e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 KOO28631.1 - 0.00011 22.6 0.0 0.0008 19.8 0.0 2.2 2 0 0 2 2 2 1 Miro-like protein Gtr1_RagA PF04670.7 KOO28631.1 - 0.021 14.0 0.0 0.069 12.2 0.0 1.9 2 1 0 2 2 2 0 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KOO28631.1 - 0.074 12.4 0.0 0.24 10.8 0.0 2.0 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain CobS PF02654.10 KOO28632.1 - 3.1e-24 85.8 5.6 1e-23 84.1 3.9 1.7 1 1 0 1 1 1 1 Cobalamin-5-phosphate synthase adh_short PF00106.20 KOO28634.1 - 2.3e-28 99.1 12.8 4.1e-27 95.1 6.9 2.5 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.5 KOO28634.1 - 2.5e-17 63.1 8.8 2.6e-17 63.0 4.3 2.1 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.1 KOO28634.1 - 4.7e-09 36.3 0.0 4e-08 33.3 0.0 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Eno-Rase_NADH_b PF12242.3 KOO28634.1 - 0.2 11.4 2.6 0.58 9.9 0.0 2.8 3 0 0 3 3 3 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase HAT PF02184.11 KOO28635.1 - 9e-23 79.7 58.1 7.1e-10 38.4 0.4 13.5 13 1 0 13 13 13 5 HAT (Half-A-TPR) repeat TPR_14 PF13428.1 KOO28635.1 - 3.7e-16 58.1 38.0 0.0085 16.6 0.0 12.5 5 3 8 13 13 13 5 Tetratricopeptide repeat TPR_19 PF14559.1 KOO28635.1 - 1.8e-15 57.0 9.2 0.039 14.3 0.0 7.3 4 2 2 7 7 7 5 Tetratricopeptide repeat Suf PF05843.9 KOO28635.1 - 4.6e-15 56.0 8.3 1e-05 25.4 2.2 5.2 2 2 2 4 4 4 4 Suppressor of forked protein (Suf) TPR_16 PF13432.1 KOO28635.1 - 1.1e-13 51.4 35.3 0.00018 22.0 0.0 8.5 5 3 4 10 10 9 6 Tetratricopeptide repeat TPR_2 PF07719.12 KOO28635.1 - 1.6e-06 27.5 19.7 7.2 6.7 0.0 10.2 12 0 0 12 12 12 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO28635.1 - 4e-05 23.4 13.4 1.7 8.6 0.0 6.5 4 2 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO28635.1 - 4.9e-05 23.1 3.8 0.045 13.9 0.1 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO28635.1 - 0.016 14.9 1.9 53 3.9 0.0 5.4 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.1 KOO28635.1 - 0.048 13.3 12.5 0.58 9.8 0.0 5.6 6 1 1 7 7 7 0 TPR repeat TPR_7 PF13176.1 KOO28635.1 - 0.53 10.2 18.4 1.7 8.6 0.0 6.6 9 0 0 9 9 7 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO28635.1 - 2.5 8.7 19.4 11 6.7 0.0 8.3 10 0 0 10 10 9 0 Tetratricopeptide repeat Ribosomal_S19 PF00203.16 KOO28636.1 - 8.4e-14 50.9 0.4 1.2e-13 50.4 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 IQ PF00612.22 KOO28637.1 - 4.9e-08 31.9 1.9 0.0013 18.1 0.1 3.0 2 0 0 2 2 2 2 IQ calmodulin-binding motif Flavin_Reduct PF01613.13 KOO28637.1 - 0.074 12.9 4.4 0.019 14.8 0.6 2.0 2 0 0 2 2 2 0 Flavin reductase like domain X PF00739.14 KOO28637.1 - 5.1 6.9 12.7 0.14 12.0 3.2 2.6 2 0 0 2 2 2 0 Trans-activation protein X Pkinase PF00069.20 KOO28638.1 - 6.4e-59 199.2 0.0 1.6e-58 197.9 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO28638.1 - 5.4e-34 117.4 0.1 2.4e-33 115.3 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Response_reg PF00072.19 KOO28638.1 - 1.9e-12 47.1 0.0 4.2e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.1 KOO28638.1 - 0.0014 17.6 0.0 0.0032 16.4 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Rep_fac_C PF08542.6 KOO28638.1 - 0.091 12.7 0.0 0.58 10.1 0.0 2.2 2 0 0 2 2 2 0 Replication factor C C-terminal domain ASL_C2 PF14698.1 KOO28638.1 - 0.19 11.8 1.7 1.7 8.7 0.1 2.8 2 0 0 2 2 2 0 Argininosuccinate lyase C-terminal PPPI_inhib PF14895.1 KOO28638.1 - 0.23 10.1 0.0 0.36 9.5 0.0 1.2 1 0 0 1 1 1 0 Protein phosphatase 1 inhibitor zf-C2HC_2 PF13913.1 KOO28638.1 - 0.36 10.5 2.1 0.3 10.8 0.2 1.8 2 0 0 2 2 2 0 zinc-finger of a C2HC-type DUF3505 PF12013.3 KOO28638.1 - 2.3 8.4 6.9 0.24 11.6 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3505) Myb_DNA-bind_6 PF13921.1 KOO28640.1 - 5.8e-05 23.1 0.0 7.3e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 KOO28640.1 - 0.033 14.2 0.0 0.049 13.7 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain Methyltransf_1N PF02870.10 KOO28640.1 - 0.11 13.0 0.0 0.24 12.0 0.0 1.5 1 1 1 2 2 2 0 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain Glyoxalase_4 PF13669.1 KOO28641.1 - 0.039 13.9 0.0 0.86 9.6 0.0 2.4 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AAA PF00004.24 KOO28642.1 - 3.1e-31 108.2 0.0 2.3e-10 40.7 0.0 4.0 4 0 0 4 4 3 3 ATPase family associated with various cellular activities (AAA) MIB_HERC2 PF06701.8 KOO28642.1 - 2.1e-12 46.8 5.4 7.3e-12 45.0 3.8 2.0 1 0 0 1 1 1 1 Mib_herc2 AAA_17 PF13207.1 KOO28642.1 - 6.6e-11 43.0 4.8 0.017 15.9 0.5 4.6 3 1 0 3 3 3 3 AAA domain AAA_22 PF13401.1 KOO28642.1 - 7.9e-10 38.9 7.6 0.1 12.7 0.0 6.8 5 3 0 5 5 4 3 AAA domain AAA_19 PF13245.1 KOO28642.1 - 1e-09 37.9 6.3 0.042 13.6 0.1 4.6 4 0 0 4 4 3 3 Part of AAA domain AAA_5 PF07728.9 KOO28642.1 - 8.9e-09 35.2 4.5 0.2 11.3 0.0 4.6 4 0 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 KOO28642.1 - 2e-08 34.5 3.2 0.019 15.2 0.0 3.7 3 0 0 3 3 3 2 AAA domain RuvB_N PF05496.7 KOO28642.1 - 4.1e-08 32.5 0.2 0.071 12.1 0.0 3.5 3 0 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 KOO28642.1 - 4.3e-08 33.3 0.2 0.35 10.8 0.0 4.2 3 0 0 3 3 3 2 AAA ATPase domain Mg_chelatase PF01078.16 KOO28642.1 - 1.9e-06 27.2 2.4 0.64 9.1 0.1 4.4 3 1 0 4 4 4 2 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 KOO28642.1 - 3.7e-06 26.8 2.4 0.13 12.0 0.1 3.7 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.12 KOO28642.1 - 1.3e-05 24.7 1.7 1.1 8.6 0.0 3.8 4 0 0 4 4 3 2 IstB-like ATP binding protein Viral_helicase1 PF01443.13 KOO28642.1 - 3.1e-05 23.6 0.3 0.44 10.0 0.0 3.7 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.1 KOO28642.1 - 5e-05 23.3 2.8 0.62 10.0 0.0 4.2 4 0 0 4 4 3 1 AAA domain RNA_helicase PF00910.17 KOO28642.1 - 0.00013 22.0 0.4 3.9 7.7 0.0 3.8 3 0 0 3 3 3 0 RNA helicase ABC_tran PF00005.22 KOO28642.1 - 0.00013 22.2 0.9 2.7 8.3 0.0 3.9 3 0 0 3 3 3 1 ABC transporter Sigma54_activat PF00158.21 KOO28642.1 - 0.00016 21.2 0.3 6.3 6.2 0.0 4.6 4 1 0 4 4 4 0 Sigma-54 interaction domain AAA_24 PF13479.1 KOO28642.1 - 0.0002 21.0 5.4 1.7 8.1 0.1 3.8 3 0 0 3 3 3 2 AAA domain MobB PF03205.9 KOO28642.1 - 0.00051 19.7 2.2 0.68 9.6 0.0 3.8 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B PDZ PF00595.19 KOO28642.1 - 0.00069 19.7 0.9 0.0018 18.4 0.1 2.0 2 0 0 2 2 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO28642.1 - 0.0011 18.8 0.1 0.0046 16.8 0.0 2.0 2 0 0 2 2 1 1 PDZ domain Sigma54_activ_2 PF14532.1 KOO28642.1 - 0.002 18.1 0.0 0.3 11.1 0.0 3.4 3 0 0 3 3 3 1 Sigma-54 interaction domain KTI12 PF08433.5 KOO28642.1 - 0.0021 17.3 0.6 3.4 6.8 0.0 3.2 3 0 0 3 3 3 1 Chromatin associated protein KTI12 AAA_2 PF07724.9 KOO28642.1 - 0.0029 17.5 0.0 1.1 9.1 0.0 3.3 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) NTPase_1 PF03266.10 KOO28642.1 - 0.003 17.2 3.3 5.7 6.6 0.1 3.5 3 0 0 3 3 3 0 NTPase Torsin PF06309.6 KOO28642.1 - 0.02 14.7 0.2 0.35 10.7 0.0 2.8 3 0 0 3 3 3 0 Torsin Mito_fiss_reg PF05308.6 KOO28642.1 - 0.053 12.8 1.5 5.4 6.3 0.2 2.5 2 0 0 2 2 2 0 Mitochondrial fission regulator AAA_10 PF12846.2 KOO28642.1 - 0.055 12.8 1.1 4 6.7 0.0 3.4 4 0 0 4 4 3 0 AAA-like domain Thymidylate_kin PF02223.12 KOO28642.1 - 0.11 11.8 4.2 9.3 5.5 0.1 3.4 3 0 0 3 3 3 0 Thymidylate kinase AAA_3 PF07726.6 KOO28642.1 - 0.14 11.7 0.3 66 3.1 0.0 3.7 4 0 0 4 4 3 0 ATPase family associated with various cellular activities (AAA) DUF3987 PF13148.1 KOO28642.1 - 0.17 10.3 0.0 0.17 10.3 0.0 4.4 7 0 0 7 7 6 0 Protein of unknown function (DUF3987) ArgK PF03308.11 KOO28642.1 - 0.18 10.5 4.0 3.7 6.2 0.1 2.8 3 0 0 3 3 2 0 ArgK protein KaiC PF06745.8 KOO28642.1 - 0.19 10.7 2.7 31 3.5 0.0 3.6 4 0 0 4 4 4 0 KaiC APS_kinase PF01583.15 KOO28642.1 - 0.22 11.1 1.3 25 4.4 0.0 3.2 3 0 0 3 3 3 0 Adenylylsulphate kinase AAA_25 PF13481.1 KOO28642.1 - 0.24 10.7 7.7 9.8 5.5 0.0 4.8 4 1 0 4 4 4 0 AAA domain PhoH PF02562.11 KOO28642.1 - 0.36 10.0 0.2 87 2.2 0.0 3.2 3 0 0 3 3 3 0 PhoH-like protein Mur_ligase_M PF08245.7 KOO28642.1 - 0.89 9.5 4.0 2.4 8.1 0.1 2.8 3 0 0 3 3 2 0 Mur ligase middle domain 6PF2K PF01591.13 KOO28642.1 - 1.5 7.8 1.3 65 2.4 0.0 2.9 3 0 0 3 3 3 0 6-phosphofructo-2-kinase NACHT PF05729.7 KOO28642.1 - 1.5 8.4 4.0 19 4.8 0.0 3.3 3 0 0 3 3 3 0 NACHT domain SKI PF01202.17 KOO28642.1 - 2.2 8.1 8.0 20 4.9 0.1 4.2 4 0 0 4 4 4 0 Shikimate kinase CbiA PF01656.18 KOO28642.1 - 3 7.2 6.9 7.1 5.9 0.2 3.1 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain ADK PF00406.17 KOO28642.1 - 3.6 7.4 4.5 24 4.7 0.1 3.3 3 0 0 3 3 3 0 Adenylate kinase AAA_21 PF13304.1 KOO28642.1 - 4.9 7.0 1.8 32 4.3 0.0 2.7 3 0 0 3 3 2 0 AAA domain Ycf1 PF05758.7 KOO28642.1 - 7.1 4.1 0.8 10 3.7 0.6 1.1 1 0 0 1 1 1 0 Ycf1 Carboxyl_trans PF01039.17 KOO28643.1 - 4e-191 635.6 0.2 4.8e-191 635.4 0.1 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.6 KOO28643.1 - 0.041 13.0 0.0 0.041 13.0 0.0 2.2 3 0 0 3 3 3 0 Malonate decarboxylase gamma subunit (MdcE) Arm PF00514.18 KOO28644.1 - 2.9e-07 30.0 4.4 3e-05 23.6 0.2 2.8 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat EF-hand_8 PF13833.1 KOO28644.1 - 0.00074 19.0 0.1 0.0021 17.6 0.0 1.7 2 0 0 2 2 2 1 EF-hand domain pair HEAT_2 PF13646.1 KOO28644.1 - 0.00093 19.4 2.5 0.0017 18.5 1.8 1.4 1 0 0 1 1 1 1 HEAT repeats EF-hand_1 PF00036.27 KOO28644.1 - 0.0061 15.7 0.0 0.029 13.6 0.0 2.0 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO28644.1 - 0.023 14.8 0.0 0.044 13.9 0.0 1.6 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.1 KOO28644.1 - 0.045 13.1 0.0 0.11 11.8 0.0 1.7 1 0 0 1 1 1 0 EF hand HEAT_EZ PF13513.1 KOO28644.1 - 0.56 10.7 6.3 1.9 9.0 2.5 2.4 1 1 1 2 2 2 0 HEAT-like repeat PMSR PF01625.16 KOO28645.1 - 6.7e-08 32.5 0.0 1.8e-07 31.1 0.0 1.7 1 1 0 1 1 1 1 Peptide methionine sulfoxide reductase TPR_17 PF13431.1 KOO28645.1 - 0.012 15.7 0.1 0.085 13.0 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat SNARE_assoc PF09335.6 KOO28646.1 - 6.4e-07 29.6 2.5 6.6e-07 29.5 0.7 1.7 1 1 1 2 2 2 2 SNARE associated Golgi protein DUF4574 PF15141.1 KOO28647.1 - 0.072 12.8 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4574) TPR_11 PF13414.1 KOO28648.1 - 3.3e-16 58.6 0.9 3.1e-11 42.7 0.3 2.6 2 1 1 3 3 3 2 TPR repeat TPR_16 PF13432.1 KOO28648.1 - 2.1e-12 47.3 11.7 8.2e-09 35.9 2.0 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO28648.1 - 4.7e-11 41.7 1.9 0.0029 17.3 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO28648.1 - 4.3e-10 38.9 0.0 0.00058 19.8 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO28648.1 - 5.2e-09 36.3 3.7 0.00029 21.1 0.0 3.9 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO28648.1 - 3.9e-07 29.3 0.0 0.0017 17.8 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28648.1 - 5e-07 29.7 10.3 0.0016 18.8 0.0 4.4 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO28648.1 - 9.9e-07 28.1 1.0 0.0037 16.9 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 KOO28648.1 - 1.1e-06 28.6 0.6 0.4 11.2 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO28648.1 - 8.9e-06 25.5 0.6 0.0014 18.5 0.1 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO28648.1 - 0.0066 16.2 0.4 0.15 11.9 0.2 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO28648.1 - 0.0086 15.7 0.0 0.17 11.7 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 KOO28648.1 - 0.027 14.5 0.0 0.11 12.6 0.0 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.12 KOO28648.1 - 1.2 9.3 10.9 0.47 10.7 3.1 2.9 2 1 0 2 2 2 0 Bacterial transcriptional activator domain TPR_4 PF07721.9 KOO28648.1 - 2.8 8.6 12.8 8.4 7.1 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat ABC2_membrane PF01061.19 KOO28649.1 - 1.7e-23 82.9 7.5 3e-23 82.1 5.2 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_2 PF12679.2 KOO28649.1 - 0.044 12.6 4.9 0.079 11.7 3.4 1.5 1 0 0 1 1 1 0 ABC-2 family transporter protein ABC2_membrane_3 PF12698.2 KOO28649.1 - 0.2 10.6 5.9 0.37 9.7 4.1 1.5 1 0 0 1 1 1 0 ABC-2 family transporter protein DnaJ PF00226.26 KOO28650.1 - 4.1e-20 71.2 0.5 7.3e-20 70.4 0.3 1.4 1 0 0 1 1 1 1 DnaJ domain Peptidase_S24 PF00717.18 KOO28650.1 - 5.5e-07 29.1 0.0 1e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.4 KOO28650.1 - 0.0051 16.3 0.0 0.14 11.6 0.0 2.4 1 1 1 2 2 2 1 Signal peptidase, peptidase S26 SOR_SNZ PF01680.12 KOO28651.1 - 2.5e-98 327.7 3.5 3.8e-98 327.2 2.4 1.3 1 0 0 1 1 1 1 SOR/SNZ family SNO PF01174.14 KOO28651.1 - 1.9e-39 135.2 0.0 3.5e-39 134.3 0.0 1.4 1 0 0 1 1 1 1 SNO glutamine amidotransferase family ThiG PF05690.9 KOO28651.1 - 2.5e-07 30.0 2.2 2e-06 27.0 0.0 2.3 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG GATase_3 PF07685.9 KOO28651.1 - 4.2e-07 29.6 0.0 7.6e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.23 KOO28651.1 - 0.00089 18.7 0.0 0.0023 17.3 0.0 1.7 1 1 0 1 1 1 1 Glutamine amidotransferase class-I His_biosynth PF00977.16 KOO28651.1 - 0.0013 18.0 0.0 0.009 15.3 0.0 2.0 2 0 0 2 2 2 1 Histidine biosynthesis protein NMO PF03060.10 KOO28651.1 - 0.0017 17.5 0.2 0.0038 16.4 0.1 1.5 1 0 0 1 1 1 1 Nitronate monooxygenase DJ-1_PfpI PF01965.19 KOO28651.1 - 0.015 14.7 0.0 0.05 13.0 0.0 1.8 1 0 0 1 1 1 0 DJ-1/PfpI family IGPS PF00218.16 KOO28651.1 - 0.065 12.2 0.0 0.13 11.2 0.0 1.5 1 0 0 1 1 1 0 Indole-3-glycerol phosphate synthase TPR_11 PF13414.1 KOO28653.1 - 2.1e-06 27.2 1.8 0.037 13.6 0.0 4.3 4 0 0 4 4 4 2 TPR repeat TPR_19 PF14559.1 KOO28653.1 - 0.0054 17.0 13.0 1.2 9.5 1.8 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO28653.1 - 0.0072 16.2 9.6 0.97 9.4 0.1 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO28653.1 - 0.0091 15.8 8.0 19 5.4 0.0 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO28653.1 - 0.055 13.6 0.0 2.1 8.7 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat PKD_channel PF08016.7 KOO28655.1 - 1.3e-11 43.6 10.6 8.3e-11 40.9 0.1 2.1 2 0 0 2 2 2 2 Polycystin cation channel Clathrin_lg_ch PF01086.12 KOO28656.1 - 2.1e-24 86.7 1.7 2.6e-24 86.3 1.2 1.1 1 0 0 1 1 1 1 Clathrin light chain Fork_head_N PF08430.7 KOO28656.1 - 0.042 14.2 17.5 0.068 13.5 12.1 1.4 1 0 0 1 1 1 0 Forkhead N-terminal region Adeno_PIX PF03955.9 KOO28656.1 - 1.2 9.6 4.0 18 5.9 0.1 2.3 1 1 1 2 2 2 0 Adenovirus hexon-associated protein (IX) HMG_box PF00505.14 KOO28658.1 - 1e-20 73.7 3.5 2.5e-20 72.5 2.4 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO28658.1 - 2.9e-13 49.9 3.5 2.9e-13 49.9 2.4 2.0 1 1 0 1 1 1 1 HMG-box domain Imm35 PF15581.1 KOO28658.1 - 0.0095 15.9 0.5 1 9.4 0.2 2.5 2 0 0 2 2 2 1 Immunity protein 35 CHDNT PF08073.7 KOO28658.1 - 0.015 14.9 0.1 0.034 13.8 0.0 1.5 1 0 0 1 1 1 0 CHDNT (NUC034) domain BNR_assoc_N PF14873.1 KOO28658.1 - 0.064 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of BNR-repeat neuraminidase Myb_DNA-binding PF00249.26 KOO28659.1 - 7.6e-34 115.5 5.2 2.4e-16 59.4 0.5 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO28659.1 - 2.4e-28 97.9 3.9 2.5e-16 59.5 0.1 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 KOO28659.1 - 0.12 12.5 5.8 5 7.3 0.4 2.7 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain GA PF01468.12 KOO28659.1 - 0.24 11.5 6.3 0.17 12.0 0.3 2.6 3 0 0 3 3 3 0 GA module Myb_DNA-bind_5 PF13873.1 KOO28659.1 - 0.5 10.2 4.6 7.5 6.5 0.0 2.5 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain DUF2057 PF09829.4 KOO28659.1 - 0.84 9.2 3.3 3.3 7.3 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) EF-hand_7 PF13499.1 KOO28660.1 - 3.2e-13 49.6 0.2 5.3e-08 32.8 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO28660.1 - 2.1e-12 45.8 3.2 0.012 15.4 0.1 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.27 KOO28660.1 - 1.6e-11 42.6 10.3 0.00029 19.9 0.2 4.2 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO28660.1 - 7.5e-10 38.2 1.2 5.6e-08 32.2 0.5 3.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO28660.1 - 1.6e-05 23.9 7.5 0.37 10.2 0.0 4.1 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.1 KOO28660.1 - 0.0054 16.6 0.1 1.1 9.2 0.0 3.0 2 1 0 2 2 2 1 EF-hand domain Asn_synthase PF00733.16 KOO28660.1 - 0.014 14.9 0.1 0.027 13.9 0.0 1.5 1 0 0 1 1 1 0 Asparagine synthase EF-hand_4 PF12763.2 KOO28660.1 - 0.089 12.5 0.3 3.3 7.4 0.0 2.5 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand SKG6 PF08693.5 KOO28661.1 - 1.1e-05 24.6 2.9 1.1e-05 24.6 2.0 2.6 4 0 0 4 4 4 1 Transmembrane alpha-helix domain FUN14 PF04930.10 KOO28661.1 - 0.02 15.1 0.1 0.05 13.8 0.0 1.7 2 0 0 2 2 2 0 FUN14 family PSI_PSAK PF01241.13 KOO28661.1 - 0.025 14.6 3.8 0.034 14.1 0.0 2.2 2 0 0 2 2 2 0 Photosystem I psaG / psaK Secretin PF00263.16 KOO28661.1 - 0.13 11.6 2.9 0.25 10.6 2.0 1.4 1 0 0 1 1 1 0 Bacterial type II and III secretion system protein MARVEL PF01284.18 KOO28661.1 - 2.7 7.8 6.8 0.55 10.0 0.1 2.1 2 0 0 2 2 2 0 Membrane-associating domain Adeno_E3_CR2 PF02439.10 KOO28661.1 - 3.9 7.0 7.3 0.15 11.6 0.8 1.8 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 Lipase_GDSL_2 PF13472.1 KOO28662.1 - 8.1e-09 35.8 0.1 1.8e-08 34.6 0.0 1.6 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family DUF1455 PF07306.6 KOO28662.1 - 0.026 14.5 1.2 0.044 13.8 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1455) Endomucin PF07010.7 KOO28662.1 - 0.03 13.6 0.0 0.062 12.6 0.0 1.4 1 0 0 1 1 1 0 Endomucin Filamin PF00630.14 KOO28663.1 - 8.5e-27 93.6 0.0 3.1e-05 24.4 0.0 5.5 5 0 0 5 5 5 5 Filamin/ABP280 repeat ECH PF00378.15 KOO28664.1 - 1.9e-43 148.3 0.1 3.1e-43 147.6 0.1 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Baculo_PEP_C PF04513.7 KOO28665.1 - 0.00017 21.4 2.0 0.91 9.3 0.0 4.1 3 1 1 4 4 4 2 Baculovirus polyhedron envelope protein, PEP, C terminus LXG PF04740.7 KOO28665.1 - 0.0028 17.4 5.6 0.021 14.6 0.1 3.6 2 2 0 3 3 3 1 LXG domain of WXG superfamily DUF4515 PF14988.1 KOO28665.1 - 0.0039 16.8 1.5 0.0039 16.8 1.0 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF4515) Spc7 PF08317.6 KOO28665.1 - 0.11 11.1 15.4 0.14 10.7 1.1 3.2 2 1 0 3 3 3 0 Spc7 kinetochore protein Reo_sigmaC PF04582.7 KOO28665.1 - 0.11 11.6 2.9 0.3 10.2 0.1 2.7 1 1 1 3 3 3 0 Reovirus sigma C capsid protein Erp_C PF06780.6 KOO28665.1 - 0.37 10.6 1.9 1.2 9.0 0.1 2.5 2 1 0 2 2 2 0 Erp protein C-terminus CorA PF01544.13 KOO28665.1 - 0.46 9.4 8.3 0.47 9.4 0.9 2.7 2 1 1 3 3 3 0 CorA-like Mg2+ transporter protein TBPIP PF07106.8 KOO28665.1 - 1.4 8.4 9.7 5.2 6.5 0.6 3.5 2 1 2 4 4 4 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TPR_12 PF13424.1 KOO28667.1 - 6.2e-08 32.4 2.9 2e-07 30.8 1.9 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat EF-hand_6 PF13405.1 KOO28667.1 - 1.1e-05 24.9 0.0 0.18 11.7 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain TPR_1 PF00515.23 KOO28667.1 - 1.7e-05 24.1 0.9 0.0039 16.7 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO28667.1 - 4.1e-05 23.1 1.2 7.9e-05 22.2 0.8 1.5 1 0 0 1 1 1 1 TPR repeat EF-hand_7 PF13499.1 KOO28667.1 - 6.2e-05 23.0 0.0 0.00062 19.8 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair TPR_2 PF07719.12 KOO28667.1 - 6.3e-05 22.5 3.3 0.013 15.3 0.2 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat EF-hand_1 PF00036.27 KOO28667.1 - 0.00012 21.1 0.1 0.19 11.1 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO28667.1 - 0.0003 20.3 0.1 0.035 13.7 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO28667.1 - 0.0017 17.6 0.1 0.17 11.2 0.0 2.4 2 0 0 2 2 2 1 EF hand TPR_16 PF13432.1 KOO28667.1 - 0.0024 18.4 1.5 0.0024 18.4 1.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.1 KOO28667.1 - 0.0032 17.3 0.5 0.0032 17.3 0.4 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat MAGE_N PF12440.3 KOO28669.1 - 0.048 13.9 1.4 0.057 13.6 1.0 1.2 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal Herpes_capsid PF06112.6 KOO28669.1 - 0.44 10.5 3.0 0.48 10.4 2.1 1.1 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein ANTH PF07651.11 KOO28670.1 - 1.4e-08 33.8 0.5 2e-08 33.3 0.4 1.2 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.15 KOO28670.1 - 2.1e-05 24.4 0.0 3.5e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 ENTH domain DUF1009 PF06230.6 KOO28672.1 - 0.075 12.3 1.4 3.9 6.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1009) DUF3640 PF12342.3 KOO28672.1 - 0.45 10.0 16.8 58 3.3 0.2 7.6 9 0 0 9 9 9 0 Protein of unknown function (DUF3640) Sel1 PF08238.7 KOO28673.1 - 9.9e-40 134.0 45.6 2.7e-07 30.9 0.6 8.0 8 0 0 8 8 8 6 Sel1 repeat U-box PF04564.10 KOO28673.1 - 1.7e-17 63.1 0.0 2.6e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO28673.1 - 0.00019 20.8 0.0 0.00041 19.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Erythro-docking PF09277.6 KOO28673.1 - 0.035 13.7 24.0 1.6 8.5 0.1 7.0 5 1 3 8 8 8 0 Erythronolide synthase, docking TTL PF03133.10 KOO28674.1 - 4.8e-56 189.8 0.0 6.5e-56 189.4 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 KOO28674.1 - 3.1e-05 22.9 0.0 0.00054 18.8 0.0 2.2 2 0 0 2 2 2 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.1 KOO28674.1 - 0.003 16.6 0.0 0.74 8.8 0.0 2.1 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.9 KOO28674.1 - 0.081 12.7 0.0 0.23 11.3 0.0 1.6 2 0 0 2 2 2 0 ATP-grasp domain RabGAP-TBC PF00566.13 KOO28675.1 - 2.3e-17 63.2 0.0 2.8e-17 62.8 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain MarC PF01914.12 KOO28675.1 - 0.16 11.0 0.1 0.25 10.4 0.1 1.2 1 0 0 1 1 1 0 MarC family integral membrane protein TOH_N PF12549.3 KOO28675.1 - 6.7 6.4 7.7 0.47 10.0 1.8 1.8 2 0 0 2 2 2 0 Tyrosine hydroxylase N terminal RNase_PH PF01138.16 KOO28677.1 - 1.8e-22 80.0 0.0 9.1e-15 55.1 0.0 2.4 2 0 0 2 2 2 2 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 KOO28677.1 - 2.9e-09 36.7 0.0 7.3e-09 35.4 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 zf-CSL PF05207.8 KOO28678.1 - 2.2e-19 68.6 0.5 3e-19 68.2 0.4 1.2 1 0 0 1 1 1 1 CSL zinc finger zinc_ribbon_5 PF13719.1 KOO28678.1 - 0.0075 15.8 0.4 0.013 15.0 0.3 1.5 1 0 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_4 PF13717.1 KOO28678.1 - 0.038 13.6 0.4 0.067 12.9 0.3 1.5 1 0 0 1 1 1 0 zinc-ribbon domain Zn-ribbon_8 PF09723.5 KOO28678.1 - 0.061 13.2 0.7 0.12 12.4 0.5 1.4 1 0 0 1 1 1 0 Zinc ribbon domain DUF4087 PF13316.1 KOO28678.1 - 0.076 13.2 0.1 0.084 13.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4087) zf-TFIIB PF13453.1 KOO28678.1 - 0.18 11.0 1.3 0.3 10.3 0.9 1.4 1 0 0 1 1 1 0 Transcription factor zinc-finger WW PF00397.21 KOO28679.1 - 5.6e-10 38.9 0.4 9.9e-10 38.1 0.3 1.4 1 0 0 1 1 1 1 WW domain KOW PF00467.24 KOO28683.1 - 0.11 12.3 3.3 13 5.6 0.1 3.7 3 0 0 3 3 3 0 KOW motif DnaJ PF00226.26 KOO28685.1 - 1.3e-23 82.4 1.0 2.3e-23 81.6 0.7 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.1 KOO28685.1 - 2.7e-08 33.3 0.0 9.1e-06 25.0 0.0 2.3 2 0 0 2 2 2 2 X-domain of DnaJ-containing Chromate_transp PF02417.10 KOO28688.1 - 1.5e-06 27.8 1.4 1.7e-05 24.5 0.2 2.1 2 0 0 2 2 2 1 Chromate transporter ARGLU PF15346.1 KOO28688.1 - 0.56 9.9 25.8 1 9.1 17.9 1.4 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 GBP_C PF02841.9 KOO28688.1 - 8.3 5.4 15.2 13 4.8 10.5 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain LRR_6 PF13516.1 KOO28689.1 - 0.0011 18.8 5.0 0.5 10.6 0.0 3.4 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.28 KOO28689.1 - 0.0098 15.7 3.0 4.9 7.5 0.3 3.1 3 0 0 3 3 3 2 Leucine Rich Repeat LRR_4 PF12799.2 KOO28689.1 - 0.015 14.9 1.1 2.3 7.9 0.1 2.3 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) GlutR_N PF05201.10 KOO28689.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, N-terminal domain Pkinase PF00069.20 KOO28691.1 - 7.8e-52 175.9 0.0 9.9e-52 175.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO28691.1 - 3.4e-32 111.5 0.0 4.2e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO28691.1 - 6e-06 26.1 3.9 0.0083 15.8 0.0 3.0 1 1 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO28691.1 - 8.3e-06 24.9 0.0 0.0026 16.7 0.0 2.1 2 0 0 2 2 2 2 Kinase-like Seadorna_VP7 PF07387.6 KOO28691.1 - 0.062 12.1 0.0 0.099 11.4 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase PF00069.20 KOO28692.1 - 1.3e-49 168.7 0.1 1.7e-49 168.2 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO28692.1 - 1.1e-32 113.0 0.1 1.8e-32 112.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO28692.1 - 8.1e-05 21.7 0.0 0.00011 21.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Csm1 PF12539.3 KOO28693.1 - 0.00012 22.5 0.0 0.0003 21.2 0.0 1.8 1 1 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 Filament PF00038.16 KOO28693.1 - 0.024 14.1 0.7 0.037 13.5 0.5 1.3 1 0 0 1 1 1 0 Intermediate filament protein MscS_porin PF12795.2 KOO28693.1 - 0.6 9.3 10.4 0.51 9.6 1.0 2.3 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Toxin_39 PF15500.1 KOO28693.1 - 0.71 10.0 4.7 8 6.6 3.3 2.4 1 1 0 1 1 1 0 Putative RNase-like toxin DUF4140 PF13600.1 KOO28693.1 - 1.1 9.6 7.8 9.2 6.7 1.3 2.5 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF2285 PF10074.4 KOO28693.1 - 3.6 7.9 7.8 0.31 11.4 0.9 2.1 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2285) LRR_6 PF13516.1 KOO28694.1 - 1.8e-26 89.1 28.7 1.6 9.0 0.0 17.1 17 0 0 17 17 17 8 Leucine Rich repeat LRR_1 PF00560.28 KOO28694.1 - 5.2e-19 65.3 13.7 5.9 7.3 0.0 13.3 15 0 0 15 15 15 6 Leucine Rich Repeat LRR_4 PF12799.2 KOO28694.1 - 4.3e-11 42.1 15.0 0.49 10.0 0.1 11.3 12 2 0 12 12 12 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO28694.1 - 1.8e-08 33.9 6.6 46 3.8 0.0 10.8 13 0 0 13 13 13 0 Leucine rich repeat LRR_7 PF13504.1 KOO28694.1 - 6.9e-05 22.4 26.4 16 6.2 0.1 11.2 15 0 0 15 15 15 1 Leucine rich repeat Phage_DsbA PF11126.3 KOO28694.1 - 0.0026 17.8 0.1 0.95 9.5 0.0 2.7 2 0 0 2 2 2 1 Transcriptional regulator DsbA DUF4112 PF13430.1 KOO28694.1 - 0.015 15.2 1.2 9.8 6.1 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4112) SpoU_sub_bind PF08032.7 KOO28694.1 - 0.055 13.6 2.9 16 5.7 0.0 4.5 5 0 0 5 5 5 0 RNA 2'-O ribose methyltransferase substrate binding Dispanin PF04505.7 KOO28694.1 - 3.8 7.1 8.3 78 2.9 0.0 4.8 6 0 0 6 6 6 0 Interferon-induced transmembrane protein Aminotran_4 PF01063.14 KOO28695.1 - 7.4e-29 100.8 0.0 8.8e-29 100.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class IV Peptidase_S9 PF00326.16 KOO28696.1 - 7.3e-38 129.9 0.0 1.8e-37 128.6 0.0 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family Acetyltransf_1 PF00583.19 KOO28696.1 - 3.7e-12 46.0 0.0 1.4e-11 44.2 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Peptidase_S9_N PF02897.10 KOO28696.1 - 1.8e-11 43.3 0.0 1.6e-07 30.2 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase, N-terminal beta-propeller domain Acetyltransf_10 PF13673.1 KOO28696.1 - 9.3e-07 28.9 0.4 2.2e-06 27.7 0.1 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 KOO28696.1 - 5.3e-06 26.0 0.0 1.2e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.1 KOO28696.1 - 1.8e-05 24.6 0.0 3.3e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 KOO28696.1 - 0.00016 21.7 0.0 0.00032 20.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF3749 PF12568.3 KOO28696.1 - 0.098 12.2 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Clathrin_propel PF01394.15 KOO28698.1 - 6.5e-35 117.0 3.5 3.1e-06 27.1 0.0 7.4 7 0 0 7 7 7 7 Clathrin propeller repeat Clathrin_H_link PF13838.1 KOO28698.1 - 4.4e-29 100.1 1.3 7.6e-29 99.4 0.2 2.0 2 0 0 2 2 2 1 Clathrin-H-link Clathrin-link PF09268.5 KOO28698.1 - 4.6e-08 31.9 0.4 1.7e-07 30.1 0.0 2.1 2 0 0 2 2 2 1 Clathrin, heavy-chain linker Clathrin PF00637.15 KOO28698.1 - 0.05 13.1 0.0 0.89 9.1 0.0 2.7 3 0 0 3 3 3 0 Region in Clathrin and VPS Lumazine_bd PF12870.2 KOO28698.1 - 0.12 12.4 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Lumazine-binding domain Lactonase PF10282.4 KOO28699.1 - 0.00024 20.2 0.0 0.099 11.6 0.0 2.4 2 0 0 2 2 2 2 Lactonase, 7-bladed beta-propeller WD40 PF00400.27 KOO28700.1 - 5.1e-49 162.4 12.6 3.1e-12 45.8 0.4 4.3 4 0 0 4 4 4 4 WD domain, G-beta repeat HEM4 PF02602.10 KOO28700.1 - 2.9e-17 62.6 2.3 4.9e-17 61.9 1.6 1.3 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD PD40 PF07676.7 KOO28700.1 - 1.4e-09 37.3 0.2 0.8 9.4 0.0 4.4 4 0 0 4 4 4 4 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.6 KOO28700.1 - 0.016 13.9 0.7 7.8 5.1 0.0 2.9 1 1 2 3 3 3 0 Nup133 N terminal like DUF1513 PF07433.6 KOO28700.1 - 0.02 13.7 0.0 0.062 12.1 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1513) DUF3312 PF11768.3 KOO28700.1 - 0.022 13.0 0.0 1.2 7.2 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3312) Cpn60_TCP1 PF00118.19 KOO28701.1 - 2.8e-126 422.0 12.8 3.3e-126 421.7 8.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DOT1 PF08123.8 KOO28701.1 - 0.013 14.8 0.1 0.027 13.8 0.1 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 MFS_1 PF07690.11 KOO28702.1 - 7.9e-23 80.7 25.2 2.1e-22 79.3 17.4 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KOO28702.1 - 2e-11 43.1 1.7 2e-11 43.1 1.2 1.8 2 0 0 2 2 2 1 Sugar (and other) transporter EF-hand_5 PF13202.1 KOO28702.1 - 6.2e-10 37.9 1.1 0.00047 19.3 0.2 2.3 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.27 KOO28702.1 - 3.7e-09 35.2 0.3 0.0027 16.8 0.3 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO28702.1 - 1.3e-08 34.3 0.2 0.0021 17.6 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO28702.1 - 1.4e-08 33.9 0.3 0.0074 16.0 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO28702.1 - 3.1e-08 33.6 0.4 5.2e-08 32.9 0.3 1.3 1 0 0 1 1 1 1 EF-hand domain pair MFS_3 PF05977.8 KOO28702.1 - 0.00015 20.0 10.0 0.00015 20.0 6.9 2.1 1 1 1 2 2 2 1 Transmembrane secretion effector DUF1228 PF06779.9 KOO28702.1 - 0.011 15.7 0.6 0.011 15.7 0.4 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1228) MFS_2 PF13347.1 KOO28702.1 - 5.7 5.2 10.4 0.19 10.1 0.6 2.2 2 1 0 2 2 2 0 MFS/sugar transport protein FKBP_C PF00254.23 KOO28703.1 - 2e-18 66.1 0.0 3.2e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.13 KOO28703.1 - 7.6e-09 35.6 0.4 2e-08 34.3 0.0 1.8 3 0 0 3 3 3 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Arm PF00514.18 KOO28704.1 - 2.7e-17 61.8 6.5 4.1e-05 23.2 0.0 5.5 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO28704.1 - 0.045 14.0 11.9 0.038 14.2 3.9 3.1 2 1 1 3 3 3 0 HEAT repeats Ric8 PF10165.4 KOO28704.1 - 0.058 12.2 0.0 0.082 11.7 0.0 1.1 1 0 0 1 1 1 0 Guanine nucleotide exchange factor synembryn MFS_1 PF07690.11 KOO28706.1 - 5.5e-17 61.5 26.9 5.5e-17 61.5 18.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily zf-H2C2_2 PF13465.1 KOO28709.1 - 1e-20 72.9 10.8 5.4e-07 29.5 0.1 3.9 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.21 KOO28709.1 - 2.6e-15 55.7 23.2 0.00017 21.7 0.2 4.4 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOO28709.1 - 9.2e-09 35.0 19.5 0.012 15.9 0.3 4.5 4 0 0 4 4 4 3 C2H2-type zinc finger DDE_5 PF13546.1 KOO28709.1 - 0.0071 15.2 0.0 0.76 8.5 0.0 2.1 1 1 1 2 2 2 2 DDE superfamily endonuclease zf-TRAF PF02176.13 KOO28709.1 - 0.12 12.7 7.5 5.2 7.5 1.0 2.9 1 1 2 3 3 3 0 TRAF-type zinc finger zf-met PF12874.2 KOO28709.1 - 9.2 6.6 10.3 11 6.3 0.2 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Spc97_Spc98 PF04130.8 KOO28710.1 - 3.3e-51 174.2 0.0 1.4e-32 112.7 0.0 2.2 1 1 1 2 2 2 2 Spc97 / Spc98 family SHIPPO-rpt PF07004.7 KOO28711.1 - 1.7e-15 56.9 34.3 0.045 14.6 0.4 8.9 9 0 0 9 9 9 8 Sperm-tail PG-rich repeat CPSF_A PF03178.10 KOO28712.1 - 7.1e-50 169.9 0.0 8.8e-50 169.5 0.0 1.1 1 0 0 1 1 1 1 CPSF A subunit region RNA_pol_L_2 PF13656.1 KOO28713.1 - 1.7e-23 81.8 0.0 2.2e-23 81.4 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 KOO28713.1 - 3.9e-06 25.8 0.0 5.7e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain LeuA_dimer PF08502.5 KOO28713.1 - 0.035 13.8 0.0 0.036 13.8 0.0 1.3 1 1 0 1 1 1 0 LeuA allosteric (dimerisation) domain Rio2_N PF09202.6 KOO28713.1 - 0.049 13.6 0.0 0.091 12.8 0.0 1.4 1 0 0 1 1 1 0 Rio2, N-terminal Pkinase PF00069.20 KOO28714.1 - 5.8e-66 222.2 0.0 6.8e-66 222.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO28714.1 - 9.4e-38 129.7 0.0 1.3e-37 129.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO28714.1 - 0.00012 21.2 0.0 0.00018 20.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO28714.1 - 0.0053 16.5 0.0 0.14 11.8 0.0 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO28714.1 - 0.014 14.3 0.0 0.023 13.6 0.0 1.3 1 0 0 1 1 1 0 Kinase-like YrbL-PhoP_reg PF10707.4 KOO28714.1 - 0.061 12.6 0.0 0.095 12.0 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DUF1737 PF08410.5 KOO28715.1 - 0.068 12.9 0.1 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1737) Ank_2 PF12796.2 KOO28716.1 - 2.1e-20 72.8 0.1 5.6e-10 39.4 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO28716.1 - 6.8e-18 64.6 0.4 4.9e-06 26.8 0.0 5.5 5 0 0 5 5 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO28716.1 - 3.1e-16 58.9 4.8 0.0019 18.3 0.0 6.2 4 2 2 6 6 5 4 Ankyrin repeats (many copies) TPR_11 PF13414.1 KOO28716.1 - 1e-11 44.3 5.6 4.2e-05 23.1 0.1 3.1 2 1 0 2 2 2 2 TPR repeat Ank_3 PF13606.1 KOO28716.1 - 1.4e-10 40.3 0.1 0.51 10.7 0.0 6.2 6 0 0 6 6 6 3 Ankyrin repeat TPR_16 PF13432.1 KOO28716.1 - 6.8e-10 39.3 17.4 9.2e-05 23.0 0.6 4.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO28716.1 - 1.4e-09 37.1 7.7 0.084 12.8 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat Ank PF00023.25 KOO28716.1 - 1.6e-09 37.0 0.7 0.0056 16.4 0.0 5.6 5 0 0 5 5 5 2 Ankyrin repeat zf-C3HC4_3 PF13920.1 KOO28716.1 - 1.4e-08 34.2 12.2 2.8e-08 33.3 8.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) TPR_12 PF13424.1 KOO28716.1 - 9.6e-08 31.8 2.2 8.7e-05 22.3 0.2 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO28716.1 - 1.5e-05 24.8 0.9 0.24 11.7 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO28716.1 - 2.9e-05 24.3 6.3 0.16 12.3 1.7 3.1 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO28716.1 - 0.00014 21.2 4.7 0.095 12.3 0.1 4.1 5 0 0 5 5 4 1 Tetratricopeptide repeat zf-C3HC4_2 PF13923.1 KOO28716.1 - 0.0009 19.2 10.6 0.0009 19.2 7.4 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) TPR_8 PF13181.1 KOO28716.1 - 0.0014 18.2 0.1 1.2 9.0 0.0 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28716.1 - 0.0026 18.2 18.1 1.2 10.0 2.2 5.5 1 1 3 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO28716.1 - 0.0034 17.0 0.1 0.5 10.2 0.0 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.1 KOO28716.1 - 0.12 12.8 6.4 46 4.7 0.4 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO28716.1 - 0.53 10.1 10.9 0.62 9.9 0.2 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 KOO28716.1 - 1.5 8.9 12.2 0.18 11.7 0.6 4.3 4 0 0 4 4 3 0 Tetratricopeptide repeat Thioredoxin PF00085.15 KOO28717.1 - 1.2e-25 89.2 0.0 2.3e-25 88.2 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_6 PF13848.1 KOO28717.1 - 8.9e-06 25.6 0.0 0.0095 15.7 0.0 2.7 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 KOO28717.1 - 0.00014 21.8 0.0 0.034 14.2 0.0 2.5 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.1 KOO28717.1 - 0.00045 20.3 0.1 0.022 14.9 0.0 3.0 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_7 PF13899.1 KOO28717.1 - 0.0014 18.6 0.0 0.0042 17.0 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin-like Glutaredoxin PF00462.19 KOO28717.1 - 0.038 13.9 0.2 10 6.2 0.0 3.8 4 0 0 4 4 4 0 Glutaredoxin Thioredoxin_3 PF13192.1 KOO28717.1 - 0.049 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin domain Thioredoxin_9 PF14595.1 KOO28717.1 - 0.061 12.8 0.1 0.17 11.4 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin DUF3293 PF11697.3 KOO28718.1 - 2.6e-10 40.2 0.4 6.1e-10 39.0 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3293) DUF2746 PF10874.3 KOO28721.1 - 0.021 15.0 0.1 0.57 10.4 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2746) ATG_C PF09333.6 KOO28721.1 - 0.055 13.6 0.2 8.9 6.5 0.1 3.3 1 1 1 2 2 2 0 ATG C terminal domain DUF760 PF05542.6 KOO28721.1 - 0.077 13.1 0.0 0.22 11.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF760) Exonuc_VII_L PF02601.10 KOO28721.1 - 0.14 11.3 0.2 0.3 10.2 0.0 1.6 2 0 0 2 2 2 0 Exonuclease VII, large subunit Bacillus_HBL PF05791.6 KOO28721.1 - 0.18 11.1 1.2 0.3 10.4 0.8 1.3 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) MIT PF04212.13 KOO28721.1 - 4.3 7.2 9.9 0.24 11.3 0.2 3.1 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain SDA1 PF05285.7 KOO28722.1 - 0.018 14.3 0.4 0.028 13.6 0.2 1.2 1 0 0 1 1 1 0 SDA1 Trm112p PF03966.11 KOO28723.1 - 7.8e-15 54.9 0.0 1e-14 54.6 0.0 1.1 1 0 0 1 1 1 1 Trm112p-like protein Glyco_transf_20 PF00982.16 KOO28725.1 - 8.3e-98 327.9 0.0 1e-97 327.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 KOO28725.1 - 2.7e-33 114.8 0.0 3.9e-32 111.0 0.0 2.1 1 1 0 1 1 1 1 Trehalose-phosphatase CBM_20 PF00686.14 KOO28725.1 - 1.2e-17 63.2 0.0 3.1e-17 61.9 0.0 1.6 1 0 0 1 1 1 1 Starch binding domain Hydrolase_3 PF08282.7 KOO28725.1 - 0.31 10.5 0.0 3.5 7.1 0.0 2.1 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase O-FucT PF10250.4 KOO28727.1 - 0.0061 15.7 0.1 0.55 9.2 0.0 2.1 2 0 0 2 2 2 2 GDP-fucose protein O-fucosyltransferase Helicase_C PF00271.26 KOO28728.1 - 1.1e-16 60.4 0.0 2.5e-16 59.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOO28728.1 - 3.3e-16 59.2 0.0 5.8e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase RQC PF09382.5 KOO28728.1 - 4.8e-13 48.7 0.0 2.1e-12 46.6 0.0 2.1 2 0 0 2 2 2 1 RQC domain HRDC PF00570.18 KOO28728.1 - 6.4e-13 48.2 0.0 1.3e-12 47.2 0.0 1.6 1 0 0 1 1 1 1 HRDC domain ResIII PF04851.10 KOO28728.1 - 0.013 15.3 0.0 0.038 13.8 0.0 1.8 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Phosphoesterase PF04185.9 KOO28730.1 - 6e-53 180.3 0.0 3.6e-50 171.2 0.0 2.1 1 1 0 1 1 1 1 Phosphoesterase family LRR_6 PF13516.1 KOO28731.1 - 9.7e-09 34.4 4.4 0.28 11.3 0.0 7.5 8 0 0 8 8 8 2 Leucine Rich repeat LRR_4 PF12799.2 KOO28731.1 - 1.9e-08 33.6 0.4 0.01 15.4 0.0 4.8 5 0 0 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO28731.1 - 2.2e-05 23.8 0.9 1.3 9.3 0.0 5.7 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_7 PF13504.1 KOO28731.1 - 0.0004 20.1 3.3 22 5.8 0.0 6.8 8 0 0 8 8 8 1 Leucine rich repeat LRR_8 PF13855.1 KOO28731.1 - 0.00045 19.9 0.9 1 9.1 0.3 4.0 2 1 1 3 3 3 2 Leucine rich repeat Glyco_trans_1_4 PF13692.1 KOO28732.1 - 3.3e-13 49.9 0.9 1.1e-12 48.3 0.0 2.3 2 2 0 2 2 2 1 Glycosyl transferases group 1 Ank PF00023.25 KOO28733.1 - 0.00016 21.3 0.1 0.0012 18.5 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeat Methyltransf_18 PF12847.2 KOO28733.1 - 0.00028 21.4 0.0 0.00049 20.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO28733.1 - 0.0015 18.5 0.5 0.003 17.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Ank_2 PF12796.2 KOO28733.1 - 0.0068 16.7 0.0 0.011 16.0 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO28733.1 - 0.017 15.3 0.2 0.86 10.0 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeat Methyltransf_23 PF13489.1 KOO28733.1 - 0.042 13.5 0.0 0.069 12.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 KOO28733.1 - 0.077 12.5 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Ank_4 PF13637.1 KOO28733.1 - 0.13 12.7 0.0 0.26 11.8 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) ADH_zinc_N PF00107.21 KOO28734.1 - 2e-14 53.2 0.2 7.6e-14 51.3 0.2 1.9 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 KOO28734.1 - 1e-13 52.2 0.0 4.3e-13 50.2 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOO28734.1 - 5.7e-11 42.1 0.1 1.5e-10 40.7 0.0 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain LRR_6 PF13516.1 KOO28735.1 - 1.5e-05 24.5 1.7 1.7 8.9 0.0 6.8 7 0 0 7 7 7 1 Leucine Rich repeat LRR_4 PF12799.2 KOO28735.1 - 0.0037 16.8 0.9 10 5.8 0.0 5.0 4 1 0 4 4 4 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO28735.1 - 0.004 16.8 2.7 18 5.2 0.0 5.0 5 0 0 5 5 5 1 Leucine rich repeat LRR_1 PF00560.28 KOO28735.1 - 0.49 10.6 3.8 21 5.6 0.0 4.8 6 0 0 6 6 6 0 Leucine Rich Repeat HA2 PF04408.18 KOO28736.1 - 3.1e-18 65.6 0.0 5.7e-18 64.8 0.0 1.4 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 KOO28736.1 - 7.1e-13 48.2 0.0 1.4e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.11 KOO28736.1 - 0.00015 21.5 0.0 0.00029 20.6 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold SMN PF06003.7 KOO28736.1 - 0.0077 15.3 0.6 0.016 14.3 0.4 1.5 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) DUF4558 PF15104.1 KOO28736.1 - 0.032 14.1 0.2 0.068 13.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4558) DUF4537 PF15057.1 KOO28736.1 - 0.076 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) DEAD PF00270.24 KOO28736.1 - 0.095 12.1 0.1 0.18 11.3 0.1 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase Response_reg PF00072.19 KOO28737.1 - 3.8e-19 68.7 0.1 4.8e-19 68.4 0.1 1.1 1 0 0 1 1 1 1 Response regulator receiver domain DUF4106 PF13388.1 KOO28738.1 - 0.15 11.0 4.9 0.088 11.7 1.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4106) RCC1 PF00415.13 KOO28739.1 - 1.4e-44 150.0 5.4 1.3e-13 50.8 0.1 4.5 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO28739.1 - 8e-28 95.4 14.5 7.9e-09 34.9 0.3 4.6 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat TMF_TATA_bd PF12325.3 KOO28739.1 - 0.047 13.4 20.8 0.24 11.1 0.3 3.5 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding IncA PF04156.9 KOO28739.1 - 0.17 11.4 22.9 0.48 9.9 0.0 3.4 3 0 0 3 3 3 0 IncA protein V_ATPase_I PF01496.14 KOO28739.1 - 0.65 7.7 1.9 2.1 6.1 0.7 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family PilO PF04350.8 KOO28739.1 - 2.6 7.9 9.3 0.27 11.0 2.4 2.4 2 0 0 2 2 2 0 Pilus assembly protein, PilO APG6 PF04111.7 KOO28739.1 - 5.2 6.0 16.7 0.084 11.8 2.4 2.9 3 0 0 3 3 3 0 Autophagy protein Apg6 DUF2240 PF09999.4 KOO28740.1 - 0.01 15.2 1.0 0.012 15.0 0.7 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2240) Methyltransf_6 PF03737.10 KOO28741.1 - 2.1e-19 69.9 0.0 3.4e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 Demethylmenaquinone methyltransferase Rep_fac_C PF08542.6 KOO28742.1 - 9.7e-20 70.3 0.0 4.9e-19 68.1 0.0 2.0 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA PF00004.24 KOO28742.1 - 1.4e-14 54.4 0.1 2.1e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 KOO28742.1 - 1.1e-10 41.3 0.0 8.9e-09 35.2 0.0 2.2 1 1 1 2 2 2 1 DNA polymerase III, delta subunit AAA_14 PF13173.1 KOO28742.1 - 2.5e-06 27.3 0.0 3.8e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOO28742.1 - 6e-06 26.3 0.0 0.0001 22.3 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain Rad17 PF03215.10 KOO28742.1 - 1.9e-05 23.5 0.0 0.00032 19.5 0.0 2.1 1 1 0 2 2 2 1 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 KOO28742.1 - 3.4e-05 23.9 0.2 0.031 14.4 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.1 KOO28742.1 - 4.7e-05 23.0 0.0 0.00012 21.7 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain Mg_chelatase PF01078.16 KOO28742.1 - 7.3e-05 22.0 0.1 0.00073 18.7 0.0 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI RuvB_N PF05496.7 KOO28742.1 - 0.00013 21.0 0.0 0.0003 19.9 0.0 1.6 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_25 PF13481.1 KOO28742.1 - 0.00026 20.4 0.6 0.011 15.2 0.2 3.0 2 2 1 3 3 3 1 AAA domain AAA_5 PF07728.9 KOO28742.1 - 0.00048 19.8 0.1 0.0015 18.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.13 KOO28742.1 - 0.0014 18.1 0.0 0.0026 17.3 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_10 PF12846.2 KOO28742.1 - 0.0036 16.7 0.4 0.45 9.8 0.1 2.5 2 1 0 3 3 3 1 AAA-like domain AAA_11 PF13086.1 KOO28742.1 - 0.0042 16.6 0.0 0.0068 16.0 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 KOO28742.1 - 0.0054 16.7 0.0 0.0095 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.13 KOO28742.1 - 0.0095 15.4 0.1 0.023 14.1 0.0 1.7 2 0 0 2 2 1 1 FtsK/SpoIIIE family DEAD PF00270.24 KOO28742.1 - 0.01 15.3 0.2 0.61 9.5 0.0 2.4 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_3 PF07726.6 KOO28742.1 - 0.011 15.3 0.0 0.02 14.4 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.12 KOO28742.1 - 0.012 15.0 0.1 0.027 13.8 0.1 1.7 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.1 KOO28742.1 - 0.013 15.8 0.0 0.021 15.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 KOO28742.1 - 0.016 14.7 0.4 0.12 11.9 0.3 2.2 1 1 0 1 1 1 0 AAA domain SNF2_N PF00176.18 KOO28742.1 - 0.025 13.3 0.1 2.5 6.8 0.0 2.1 2 0 0 2 2 2 0 SNF2 family N-terminal domain RNA_helicase PF00910.17 KOO28742.1 - 0.028 14.5 0.0 0.11 12.6 0.0 1.9 1 1 0 1 1 1 0 RNA helicase AAA_29 PF13555.1 KOO28742.1 - 0.031 13.8 0.0 0.07 12.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NTPase_1 PF03266.10 KOO28742.1 - 0.031 13.9 0.7 0.24 11.1 0.1 2.2 1 1 0 2 2 2 0 NTPase AAA_17 PF13207.1 KOO28742.1 - 0.047 14.4 0.1 0.1 13.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain PrpR_N PF06506.6 KOO28742.1 - 0.048 13.0 0.0 0.11 11.8 0.0 1.6 1 0 0 1 1 1 0 Propionate catabolism activator T2SE PF00437.15 KOO28742.1 - 0.061 12.2 0.0 0.1 11.4 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein KTI12 PF08433.5 KOO28742.1 - 0.072 12.2 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_24 PF13479.1 KOO28742.1 - 0.075 12.6 0.1 0.14 11.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain ArgK PF03308.11 KOO28742.1 - 0.09 11.5 0.0 0.18 10.5 0.0 1.5 1 0 0 1 1 1 0 ArgK protein PhoH PF02562.11 KOO28742.1 - 0.1 11.8 0.7 3.9 6.6 0.0 2.3 1 1 0 2 2 2 0 PhoH-like protein DUF2075 PF09848.4 KOO28742.1 - 0.16 10.9 0.3 2.4 7.0 0.2 2.2 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) HAP1_N PF04849.8 KOO28743.1 - 0.012 14.5 10.2 0.23 10.3 0.7 2.7 1 1 2 3 3 3 0 HAP1 N-terminal conserved region DUF972 PF06156.8 KOO28743.1 - 0.58 10.5 5.7 4.6 7.6 0.9 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Pex19 PF04614.7 KOO28743.1 - 1.8 8.1 4.5 1.5 8.4 1.7 1.8 1 1 1 2 2 2 0 Pex19 protein family Atg14 PF10186.4 KOO28743.1 - 4.9 5.9 14.5 1.1 8.1 3.8 2.3 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 IncA PF04156.9 KOO28743.1 - 7.7 6.0 15.8 1 8.8 7.2 1.9 1 1 1 2 2 2 0 IncA protein DREV PF05219.7 KOO28745.1 - 8.5e-25 87.1 0.0 1.4e-24 86.4 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_23 PF13489.1 KOO28745.1 - 9.9e-11 41.6 0.0 1.6e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO28745.1 - 2.7e-10 40.5 0.0 5.4e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO28745.1 - 1.8e-08 34.7 0.0 3.3e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO28745.1 - 4.7e-08 33.5 0.1 1.7e-07 31.8 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO28745.1 - 0.00024 20.7 0.0 0.002 17.7 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.6 KOO28745.1 - 0.049 12.3 0.0 0.071 11.7 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1698) MTS PF05175.9 KOO28745.1 - 0.17 11.2 0.0 0.85 8.9 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase small domain Arf PF00025.16 KOO28747.1 - 4.8e-56 188.7 0.0 6e-56 188.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 KOO28747.1 - 4.8e-12 45.5 0.0 5.8e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 KOO28747.1 - 3.3e-10 39.1 0.1 3.3e-07 29.3 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Miro PF08477.8 KOO28747.1 - 5e-10 39.9 0.0 7.8e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein SRPRB PF09439.5 KOO28747.1 - 1.4e-09 37.4 0.0 1.8e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 KOO28747.1 - 4.2e-06 26.6 0.0 6.5e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 KOO28747.1 - 1.2e-05 24.5 0.0 1.7e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region NACHT PF05729.7 KOO28747.1 - 0.0011 18.6 0.4 0.011 15.3 0.3 2.3 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 KOO28747.1 - 0.0012 18.8 3.0 0.003 17.5 0.0 2.4 2 1 1 3 3 3 1 AAA ATPase domain AAA_33 PF13671.1 KOO28747.1 - 0.015 15.1 0.2 0.12 12.2 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_17 PF13207.1 KOO28747.1 - 0.018 15.8 0.2 0.033 15.0 0.2 1.8 1 1 0 1 1 1 0 AAA domain cobW PF02492.14 KOO28747.1 - 0.033 13.6 0.0 6.4 6.1 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.1 KOO28747.1 - 0.033 14.4 0.1 0.091 13.0 0.1 1.9 1 1 0 1 1 1 0 AAA domain DAP3 PF10236.4 KOO28747.1 - 0.035 13.0 0.0 0.053 12.4 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 PduV-EutP PF10662.4 KOO28747.1 - 0.056 12.9 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_19 PF13245.1 KOO28747.1 - 0.065 12.9 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain AAA_14 PF13173.1 KOO28747.1 - 0.089 12.6 0.1 0.27 11.1 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.1 KOO28747.1 - 0.097 12.8 0.1 0.19 11.8 0.1 1.7 1 1 0 1 1 1 0 AAA domain Rad17 PF03215.10 KOO28747.1 - 0.12 10.9 0.0 0.17 10.4 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_28 PF13521.1 KOO28747.1 - 0.15 12.0 0.1 0.4 10.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.17 KOO28747.1 - 0.16 11.3 0.0 0.32 10.4 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain RecO_N PF11967.3 KOO28748.1 - 0.017 14.9 0.0 0.031 14.1 0.0 1.4 1 0 0 1 1 1 0 Recombination protein O N terminal RVT_2 PF07727.9 KOO28749.1 - 2.5e-29 101.9 0.0 3.7e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2293 PF10056.4 KOO28749.1 - 0.062 13.2 0.1 0.17 11.8 0.1 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2293) Ank_2 PF12796.2 KOO28750.1 - 0.0018 18.6 0.0 0.0034 17.6 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO28750.1 - 0.004 17.3 0.0 0.0088 16.2 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.25 KOO28750.1 - 0.008 15.9 0.0 0.023 14.4 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank_4 PF13637.1 KOO28750.1 - 0.017 15.6 0.0 0.034 14.6 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO28750.1 - 0.11 12.8 0.0 0.33 11.3 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeat CDC45 PF02724.9 KOO28750.1 - 0.15 10.0 0.1 0.2 9.6 0.1 1.1 1 0 0 1 1 1 0 CDC45-like protein SAP PF02037.22 KOO28751.1 - 2.5e-15 55.5 0.1 2.7e-07 29.9 0.2 2.6 2 0 0 2 2 2 2 SAP domain PsbW PF07123.7 KOO28752.1 - 4e-07 30.1 2.6 7.6e-07 29.2 1.6 1.7 1 1 0 1 1 1 1 Photosystem II reaction centre W protein (PsbW) Aldedh PF00171.17 KOO28753.1 - 1e-102 343.8 0.2 3.2e-68 230.1 0.1 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family DUF1995 PF09353.5 KOO28754.1 - 1.9e-10 40.7 0.0 2.6e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1995) Ribosomal_L37e PF01907.14 KOO28756.1 - 3.8e-20 71.4 7.7 7.6e-20 70.4 5.3 1.5 1 0 0 1 1 1 1 Ribosomal protein L37e SelR PF01641.13 KOO28756.1 - 0.0021 17.7 0.3 0.0027 17.4 0.2 1.2 1 1 0 1 1 1 1 SelR domain DZR PF12773.2 KOO28756.1 - 0.0032 17.2 1.8 0.0051 16.5 1.2 1.3 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_2 PF13240.1 KOO28756.1 - 0.028 13.8 0.8 7.3 6.2 0.2 2.3 2 0 0 2 2 2 0 zinc-ribbon domain C1_3 PF07649.7 KOO28756.1 - 0.037 14.0 2.4 0.13 12.3 0.2 2.1 2 0 0 2 2 2 0 C1-like domain FeS PF04060.8 KOO28756.1 - 0.12 11.9 0.4 1.1 8.9 0.0 2.2 2 0 0 2 2 2 0 Putative Fe-S cluster HypA PF01155.14 KOO28756.1 - 0.14 11.8 1.1 0.18 11.4 0.8 1.1 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family DnaJ_CXXCXGXG PF00684.14 KOO28756.1 - 0.25 11.4 5.0 0.21 11.6 2.5 1.6 2 0 0 2 2 2 0 DnaJ central domain DUF35_N PF12172.3 KOO28756.1 - 0.25 11.2 3.2 0.48 10.4 2.2 1.5 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DUF2688 PF10892.3 KOO28756.1 - 0.26 10.9 2.9 0.61 9.7 1.9 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2688) zf-ribbon_3 PF13248.1 KOO28756.1 - 0.38 10.0 3.6 2 7.7 2.6 1.9 1 1 1 2 2 2 0 zinc-ribbon domain Cript PF10235.4 KOO28756.1 - 0.72 10.2 4.7 0.99 9.8 3.3 1.4 1 1 0 1 1 1 0 Microtubule-associated protein CRIPT Chloroa_b-bind PF00504.16 KOO28757.1 - 4.1e-28 98.6 0.1 5.3e-28 98.2 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Calpain_III PF01067.17 KOO28760.1 - 3.2e-27 94.9 0.0 3.9e-08 33.0 0.0 6.2 4 2 0 4 4 4 4 Calpain large subunit, domain III EF-hand_1 PF00036.27 KOO28760.1 - 9.5e-05 21.4 0.0 0.79 9.1 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO28760.1 - 0.038 14.1 0.1 15 5.8 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain pair Topoisom_I_N PF02919.10 KOO28761.1 - 3.8e-83 278.0 3.1 3.8e-83 278.0 2.2 2.3 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.15 KOO28761.1 - 6.3e-78 261.1 4.5 1.2e-77 260.1 3.1 1.5 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.1 KOO28761.1 - 2.7e-29 100.6 0.3 6.2e-29 99.4 0.2 1.7 1 0 0 1 1 1 1 C-terminal topoisomerase domain DUF1664 PF07889.7 KOO28761.1 - 0.0032 17.2 2.1 0.0032 17.2 1.4 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) Z1 PF10593.4 KOO28761.1 - 4.2 6.5 5.3 16 4.5 0.4 2.4 2 0 0 2 2 2 0 Z1 domain HET PF06985.6 KOO28761.1 - 7 6.8 7.4 0.27 11.3 0.4 2.2 2 0 0 2 2 2 0 Heterokaryon incompatibility protein (HET) Ion_trans PF00520.26 KOO28762.1 - 2.3e-14 53.0 7.6 2.3e-14 53.0 5.3 2.0 3 0 0 3 3 3 1 Ion transport protein Ion_trans_2 PF07885.11 KOO28762.1 - 1.6e-09 37.3 8.5 1.6e-09 37.3 5.9 2.7 2 1 0 2 2 2 1 Ion channel cNMP_binding PF00027.24 KOO28762.1 - 4.2e-05 23.2 0.0 7.8e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain DUF1246 PF06849.7 KOO28762.1 - 0.15 11.8 0.1 0.37 10.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1246) Seryl_tRNA_N PF02403.17 KOO28762.1 - 1.2 9.1 7.7 2.3 8.2 0.7 2.5 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF3811 PF11656.3 KOO28762.1 - 6 6.9 8.5 13 5.9 1.7 3.2 2 1 0 2 2 2 0 YjbD family (DUF3811) ATP-grasp_2 PF08442.5 KOO28763.1 - 1.4e-64 217.2 1.8 1.9e-64 216.7 1.2 1.2 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.14 KOO28763.1 - 9.5e-26 90.2 1.4 4.1e-25 88.1 1.0 2.1 2 0 0 2 2 2 1 CoA-ligase ATP-grasp_5 PF13549.1 KOO28763.1 - 2.8e-09 36.5 0.5 5e-09 35.6 0.3 1.4 1 0 0 1 1 1 1 ATP-grasp domain RRM_1 PF00076.17 KOO28764.1 - 1.6e-14 53.2 0.1 2.6e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO28764.1 - 8.8e-11 41.6 0.1 1.4e-10 40.9 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) SAP PF02037.22 KOO28764.1 - 9.4e-09 34.5 0.1 1.4e-08 33.9 0.1 1.3 1 0 0 1 1 1 1 SAP domain RRM_5 PF13893.1 KOO28764.1 - 1.8e-08 34.1 0.0 3e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LETM1 PF07766.8 KOO28764.1 - 0.14 11.1 0.1 0.18 10.7 0.1 1.1 1 0 0 1 1 1 0 LETM1-like protein LRR_6 PF13516.1 KOO28765.1 - 4.7e-41 134.2 8.3 8.9e-05 22.1 0.0 8.1 8 0 0 8 8 8 8 Leucine Rich repeat LRR_4 PF12799.2 KOO28765.1 - 1.2e-07 31.2 6.3 0.55 9.9 0.2 5.4 3 2 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO28765.1 - 7.7e-06 25.2 0.0 9.9 6.6 0.0 6.5 8 0 0 8 8 8 1 Leucine Rich Repeat LRR_7 PF13504.1 KOO28765.1 - 0.00078 19.2 9.4 20 5.9 0.0 7.0 8 0 0 8 8 8 0 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO28765.1 - 0.0069 16.5 7.7 2.8 8.1 0.1 4.6 2 2 4 6 6 6 1 RNA 2'-O ribose methyltransferase substrate binding LRR_8 PF13855.1 KOO28765.1 - 0.022 14.5 5.6 11 5.8 0.0 5.0 4 2 1 5 5 5 0 Leucine rich repeat CbiG_N PF11760.3 KOO28765.1 - 0.22 11.2 21.6 5.1 6.8 0.1 5.9 3 3 2 6 6 6 0 Cobalamin synthesis G N-terminal HOASN PF14515.1 KOO28765.1 - 2.3 8.6 11.9 21 5.5 0.1 4.6 1 1 5 6 6 6 0 Haem-oxygenase-associated N-terminal helices AAA_12 PF13087.1 KOO28767.1 - 1e-46 158.8 0.0 1.4e-46 158.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 KOO28767.1 - 6.6e-21 74.9 0.9 3.5e-19 69.3 0.0 2.9 3 0 0 3 3 3 1 AAA domain Viral_helicase1 PF01443.13 KOO28767.1 - 4.2e-07 29.7 0.0 0.025 14.1 0.0 2.2 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.1 KOO28767.1 - 4.1e-05 23.2 1.2 0.007 15.9 0.1 2.9 2 2 0 2 2 2 2 AAA domain UvrD_C_2 PF13538.1 KOO28767.1 - 0.00053 20.0 0.0 0.0014 18.7 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD_C PF13361.1 KOO28767.1 - 0.036 13.5 0.0 5.2 6.4 0.0 2.1 1 1 1 2 2 2 0 UvrD-like helicase C-terminal domain AAA_19 PF13245.1 KOO28767.1 - 0.055 13.2 2.7 0.095 12.4 0.3 2.5 2 0 0 2 2 2 0 Part of AAA domain HSP70 PF00012.15 KOO28768.1 - 0.1 10.4 0.0 0.14 10.0 0.0 1.1 1 0 0 1 1 1 0 Hsp70 protein Complex1_30kDa PF00329.14 KOO28768.1 - 0.15 12.3 0.0 0.3 11.3 0.0 1.5 1 0 0 1 1 1 0 Respiratory-chain NADH dehydrogenase, 30 Kd subunit CS PF04969.11 KOO28769.1 - 0.0018 18.7 0.0 0.0036 17.7 0.0 1.5 1 0 0 1 1 1 1 CS domain Colicin_V PF02674.11 KOO28769.1 - 0.084 12.7 0.1 0.16 11.8 0.1 1.3 1 0 0 1 1 1 0 Colicin V production protein DUF4662 PF15578.1 KOO28769.1 - 0.62 9.5 0.0 0.62 9.5 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4662) ICL PF00463.16 KOO28770.1 - 4.1e-208 691.8 0.6 5.1e-208 691.5 0.4 1.1 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.1 KOO28770.1 - 2.6e-13 49.7 0.0 7.2e-13 48.3 0.0 1.9 1 1 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Dynein_heavy PF03028.10 KOO28771.1 - 6.3e-237 788.1 0.0 1e-236 787.3 0.0 1.3 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DHC_N1 PF08385.7 KOO28771.1 - 4e-162 540.6 0.8 4e-162 540.6 0.6 2.0 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.8 KOO28771.1 - 4.8e-113 377.7 2.7 4.8e-113 377.7 1.9 4.4 5 1 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.2 KOO28771.1 - 2.5e-106 354.5 0.1 6.9e-106 353.1 0.0 1.8 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_6 PF12774.2 KOO28771.1 - 1.3e-103 345.5 0.0 3.8e-103 343.9 0.0 1.9 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_7 PF12775.2 KOO28771.1 - 4.4e-84 281.7 0.0 9e-84 280.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 MT PF12777.2 KOO28771.1 - 1.2e-77 261.0 12.4 2.7e-77 259.8 8.6 1.6 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_9 PF12781.2 KOO28771.1 - 5.3e-69 231.5 0.0 1.5e-68 230.0 0.0 1.8 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_5 PF07728.9 KOO28771.1 - 9e-15 54.6 0.0 3.3e-05 23.6 0.0 5.1 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA PF00004.24 KOO28771.1 - 0.18 12.0 2.8 11 6.2 0.0 3.9 4 0 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 KOO28771.1 - 1.1 9.0 6.6 47 3.8 0.0 3.9 3 0 0 3 3 3 0 Part of AAA domain UAA PF08449.6 KOO28772.1 - 2.4e-63 213.8 9.1 3e-63 213.5 6.3 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 KOO28772.1 - 0.016 15.2 4.1 0.016 15.2 2.9 2.4 2 1 0 2 2 2 0 EamA-like transporter family EmrE PF13536.1 KOO28772.1 - 2.2 8.5 12.7 0.34 11.1 0.6 3.0 2 2 0 2 2 2 0 Multidrug resistance efflux transporter RRM_1 PF00076.17 KOO28773.1 - 7.1e-21 73.6 0.0 1.1e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO28773.1 - 9.2e-16 57.5 0.0 1.5e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO28773.1 - 2.7e-10 39.9 0.0 4.8e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 KOO28773.1 - 0.026 14.2 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 KOO28773.1 - 0.038 13.8 0.0 0.063 13.1 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif MutS_III PF05192.13 KOO28775.1 - 4.1e-29 101.8 2.3 7.1e-29 101.0 1.6 1.3 1 0 0 1 1 1 1 MutS domain III MutS_II PF05188.12 KOO28775.1 - 1.7e-17 63.7 0.1 4.9e-17 62.2 0.0 1.8 2 0 0 2 2 2 1 MutS domain II MutS_I PF01624.15 KOO28775.1 - 3.7e-07 30.1 0.0 6.9e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 MutS domain I MutS_IV PF05190.13 KOO28775.1 - 5.1e-05 23.3 0.0 9.6e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 MutS family domain IV ATP12 PF07542.6 KOO28775.1 - 0.0042 17.0 0.1 0.032 14.1 0.0 2.1 2 0 0 2 2 2 1 ATP12 chaperone protein DUF2580 PF10824.3 KOO28775.1 - 0.19 12.0 2.6 5.5 7.4 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2580) DUF4337 PF14235.1 KOO28775.1 - 1.1 9.1 7.1 0.58 9.9 3.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) LRR_6 PF13516.1 KOO28776.1 - 8.1e-27 90.2 13.6 0.0018 18.1 0.0 12.6 12 0 0 12 12 12 6 Leucine Rich repeat LRR_4 PF12799.2 KOO28776.1 - 2.2e-14 52.6 0.0 0.032 13.8 0.0 7.1 6 2 0 6 6 6 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO28776.1 - 5.2e-11 41.0 0.1 18 5.8 0.0 9.9 11 0 0 11 11 11 1 Leucine Rich Repeat LRR_8 PF13855.1 KOO28776.1 - 1.3e-06 28.0 8.1 0.29 10.9 0.0 7.0 4 3 2 7 7 7 2 Leucine rich repeat LRR_7 PF13504.1 KOO28776.1 - 3.6e-05 23.2 12.9 38 5.1 0.0 10.3 12 0 0 12 12 12 0 Leucine rich repeat SE PF08491.5 KOO28777.1 - 0.1 11.3 0.0 0.38 9.5 0.0 1.8 2 0 0 2 2 2 0 Squalene epoxidase PAT1 PF09770.4 KOO28777.1 - 0.71 8.0 13.4 0.97 7.5 9.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 OmpH PF03938.9 KOO28777.1 - 1.7 8.5 11.7 3 7.7 8.1 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF381 PF04038.7 KOO28778.1 - 0.13 12.2 0.1 0.22 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF381) MutS_V PF00488.16 KOO28779.1 - 4.4e-77 258.6 0.1 5.4e-77 258.3 0.1 1.1 1 0 0 1 1 1 1 MutS domain V Pribosyltran PF00156.22 KOO28780.1 - 1.3e-11 44.2 0.2 3.1e-11 43.0 0.1 1.7 2 0 0 2 2 2 1 Phosphoribosyl transferase domain Bax1-I PF01027.15 KOO28781.1 - 7.2e-46 156.3 33.4 8.8e-46 156.0 23.1 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Pro_isomerase PF00160.16 KOO28782.1 - 3e-28 99.0 0.0 3.3e-28 98.8 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Diphtheria_R PF01324.14 KOO28782.1 - 0.13 11.7 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Diphtheria toxin, R domain Myotub-related PF06602.9 KOO28784.1 - 1.4e-76 257.5 0.0 2.1e-76 257.0 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.1 KOO28784.1 - 0.047 13.9 0.0 0.095 12.9 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family SAE2 PF08573.5 KOO28786.1 - 0.0078 16.8 0.2 0.012 16.3 0.2 1.3 1 0 0 1 1 1 1 DNA repair protein endonuclease SAE2/CtIP C-terminus TPR_11 PF13414.1 KOO28787.1 - 4.9e-13 48.5 11.3 1.3e-11 43.9 1.9 2.5 2 1 1 3 3 3 2 TPR repeat TPR_2 PF07719.12 KOO28787.1 - 7.1e-10 38.0 3.8 0.0011 18.6 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO28787.1 - 2e-09 36.6 1.9 0.081 12.5 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOO28787.1 - 8.2e-05 22.4 11.0 0.0017 18.2 1.8 3.3 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO28787.1 - 0.00038 21.0 15.1 0.00067 20.2 1.9 3.0 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28787.1 - 0.0012 19.2 14.6 0.064 13.9 0.2 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO28787.1 - 0.0031 17.8 5.4 0.0057 16.9 0.5 2.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO28787.1 - 0.039 13.7 0.5 7 6.7 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO28787.1 - 0.074 12.9 0.0 0.074 12.9 0.0 2.4 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat FlaC_arch PF05377.6 KOO28787.1 - 0.28 11.0 1.0 0.48 10.3 0.7 1.3 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) HEAT_2 PF13646.1 KOO28787.1 - 0.63 10.3 6.8 2.5 8.4 4.7 2.1 1 1 0 1 1 1 0 HEAT repeats TPR_9 PF13371.1 KOO28787.1 - 0.64 9.9 8.2 0.25 11.2 0.5 3.3 2 1 0 3 3 3 0 Tetratricopeptide repeat HemY_N PF07219.8 KOO28787.1 - 1.9 8.0 8.9 0.071 12.6 1.0 2.3 2 2 1 3 3 3 0 HemY protein N-terminus Chloroa_b-bind PF00504.16 KOO28791.1 - 4.5e-28 98.4 0.0 7.5e-28 97.7 0.0 1.3 1 0 0 1 1 1 1 Chlorophyll A-B binding protein XAP5 PF04921.9 KOO28792.1 - 2.1e-59 201.0 0.5 4e-59 200.0 0.4 1.4 1 1 0 1 1 1 1 XAP5, circadian clock regulator Methyltransf_16 PF10294.4 KOO28792.1 - 5.8e-13 48.6 0.0 1.9e-12 46.9 0.0 1.7 1 1 0 1 1 1 1 Putative methyltransferase PrmA PF06325.8 KOO28792.1 - 2.3e-08 33.4 0.9 3.1e-08 33.0 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 KOO28792.1 - 8.1e-08 32.3 4.2 8.1e-08 32.3 2.9 2.1 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 KOO28792.1 - 6.2e-07 28.9 0.1 1.3e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.2 KOO28792.1 - 3.3e-06 27.6 0.4 1.1e-05 26.0 0.1 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO28792.1 - 2.4e-05 24.5 0.1 7.2e-05 23.0 0.1 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO28792.1 - 8.3e-05 22.2 0.0 0.00024 20.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO28792.1 - 0.00017 21.3 0.0 0.00034 20.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO28792.1 - 0.0003 21.2 0.1 0.00096 19.5 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO28792.1 - 0.0029 18.0 0.2 0.012 16.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.10 KOO28792.1 - 0.003 16.9 0.0 0.0059 16.0 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Helicase_C PF00271.26 KOO28793.1 - 3e-14 52.6 0.0 9.2e-14 51.0 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain 2OG-FeII_Oxy_4 PF13661.1 KOO28793.1 - 0.072 12.7 0.1 0.67 9.6 0.0 2.2 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily Metallophos_2 PF12850.2 KOO28795.1 - 3.3e-07 30.2 0.0 6.7e-07 29.2 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 KOO28795.1 - 2.8e-05 23.6 0.0 0.00019 20.9 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_3 PF14582.1 KOO28795.1 - 0.0053 15.9 0.0 0.0084 15.2 0.0 1.3 1 1 0 1 1 1 1 Metallophosphoesterase, calcineurin superfamily EF-hand_1 PF00036.27 KOO28796.1 - 2e-09 36.0 0.8 0.0013 17.9 0.1 2.9 1 1 1 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO28796.1 - 4.1e-09 35.3 2.9 0.0012 18.1 0.1 2.8 1 1 1 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO28796.1 - 5.7e-08 31.9 1.0 0.0082 15.9 0.1 3.0 1 1 1 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO28796.1 - 1.6e-06 28.1 0.2 0.062 13.4 0.0 3.2 2 1 1 3 3 3 2 EF-hand domain pair ADPrib_exo_Tox PF03496.9 KOO28796.1 - 9.6e-05 21.6 0.0 0.00044 19.5 0.0 1.9 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme EF-hand_8 PF13833.1 KOO28796.1 - 0.00015 21.3 0.8 0.41 10.3 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain pair ART PF01129.13 KOO28796.1 - 0.0025 16.9 0.0 0.0081 15.2 0.0 1.8 1 1 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase AF1Q PF15017.1 KOO28797.1 - 0.033 14.0 2.0 0.061 13.2 1.4 1.4 1 0 0 1 1 1 0 Drug resistance and apoptosis regulator RNA_pol_Rpb6 PF01192.17 KOO28801.1 - 0.039 13.7 0.3 0.29 10.9 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase Rpb6 UPF0118 PF01594.11 KOO28803.1 - 2.2e-34 118.9 25.1 3.5e-33 114.9 17.4 2.0 1 1 0 1 1 1 1 Domain of unknown function DUF20 TraG_N PF07916.6 KOO28803.1 - 0.47 8.8 2.9 0.19 10.1 0.1 1.6 2 0 0 2 2 2 0 TraG-like protein, N-terminal region S1 PF00575.18 KOO28805.1 - 7e-46 154.1 0.9 4.9e-20 71.4 0.1 3.2 3 0 0 3 3 3 3 S1 RNA binding domain LptE PF04390.7 KOO28805.1 - 0.11 12.2 0.4 0.19 11.4 0.3 1.4 1 0 0 1 1 1 0 Lipopolysaccharide-assembly PARP PF00644.15 KOO28806.1 - 9.6e-05 21.9 0.7 0.012 15.0 0.0 2.1 1 1 1 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain DAP3 PF10236.4 KOO28807.1 - 1.9e-24 86.1 0.0 4.1e-12 45.6 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.1 KOO28807.1 - 0.0018 18.2 0.0 0.0044 17.0 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.1 KOO28807.1 - 0.015 14.7 0.0 0.033 13.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF258 PF03193.11 KOO28807.1 - 0.017 14.3 0.0 0.029 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 KOO28807.1 - 0.022 14.9 0.1 0.051 13.7 0.1 1.5 1 0 0 1 1 1 0 AAA domain Hpr_kinase_C PF07475.7 KOO28807.1 - 0.22 10.8 0.2 0.38 10.0 0.1 1.2 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain Glyco_transf_29 PF00777.13 KOO28808.1 - 4.5e-19 68.6 0.1 2.6e-13 49.7 0.0 2.2 1 1 0 2 2 2 2 Glycosyltransferase family 29 (sialyltransferase) Ank_2 PF12796.2 KOO28809.1 - 2.2e-11 43.9 1.0 1.1e-10 41.7 0.8 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO28809.1 - 9.3e-11 41.6 1.5 1.4e-05 25.1 0.6 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO28809.1 - 1.8e-08 33.7 2.3 0.00071 19.2 0.2 2.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOO28809.1 - 7.9e-07 29.4 0.1 0.0041 17.5 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO28809.1 - 0.00016 21.5 0.1 0.18 12.1 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat DUF4182 PF13790.1 KOO28809.1 - 0.035 13.8 0.0 9.5 6.1 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4182) Sec16_N PF12935.2 KOO28809.1 - 0.22 11.3 1.9 0.29 10.9 1.3 1.1 1 0 0 1 1 1 0 Vesicle coat trafficking protein Sec16 N-terminus DUF3138 PF11336.3 KOO28809.1 - 0.42 8.7 3.2 0.65 8.1 2.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) HMG_box_5 PF14887.1 KOO28810.1 - 0.0081 15.9 0.1 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box 5 HMG_box PF00505.14 KOO28810.1 - 0.095 12.9 0.1 0.16 12.2 0.1 1.5 1 1 0 1 1 1 0 HMG (high mobility group) box GILT PF03227.11 KOO28811.1 - 3.5e-08 33.2 2.4 9.4e-08 31.8 1.6 1.8 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) DUF1191 PF06697.7 KOO28811.1 - 0.038 12.8 0.0 0.043 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) EFP PF01132.15 KOO28812.1 - 6.2e-18 64.2 0.0 1.1e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor P (EF-P) OB domain Elong-fact-P_C PF09285.6 KOO28812.1 - 2.6e-12 45.9 0.7 5.2e-12 44.9 0.3 1.7 2 0 0 2 2 2 1 Elongation factor P, C-terminal EFP_N PF08207.7 KOO28812.1 - 0.00041 20.1 0.3 0.0017 18.2 0.0 2.0 2 1 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain UQ_con PF00179.21 KOO28813.1 - 1.9e-09 37.0 0.0 4.2e-09 35.9 0.0 1.5 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme UBA PF00627.26 KOO28813.1 - 4e-07 29.6 0.2 0.011 15.5 0.2 3.1 3 0 0 3 3 3 2 UBA/TS-N domain Prok-E2_B PF14461.1 KOO28813.1 - 0.00089 19.0 0.0 0.0016 18.1 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 KOO28813.1 - 0.037 13.9 0.0 0.048 13.5 0.0 1.3 1 0 0 1 1 1 0 RWD domain Prok-E2_A PF14457.1 KOO28813.1 - 0.076 12.4 0.1 0.19 11.1 0.0 1.7 2 0 0 2 2 2 0 Prokaryotic E2 family A LRR_4 PF12799.2 KOO28817.1 - 1.6e-22 78.6 13.1 8.5e-07 28.4 0.1 6.1 4 2 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO28817.1 - 2.6e-20 71.9 3.9 2.1e-06 27.3 0.4 4.2 3 1 1 4 4 4 4 Leucine rich repeat LRR_1 PF00560.28 KOO28817.1 - 4e-15 53.5 7.8 0.11 12.6 0.0 9.6 9 1 0 9 9 9 4 Leucine Rich Repeat LRR_7 PF13504.1 KOO28817.1 - 3.5e-06 26.3 11.8 2.8 8.5 0.0 7.9 10 0 0 10 10 10 2 Leucine rich repeat LRR_6 PF13516.1 KOO28817.1 - 0.0068 16.3 12.3 3.3 8.0 0.0 6.7 9 0 0 9 9 9 2 Leucine Rich repeat F-box-like PF12937.2 KOO28818.1 - 0.17 11.6 2.8 2.1 8.1 0.1 2.6 2 0 0 2 2 2 0 F-box-like Daxx PF03344.10 KOO28819.1 - 0.0079 14.7 5.3 0.0086 14.6 3.7 1.0 1 0 0 1 1 1 1 Daxx Family Vma12 PF11712.3 KOO28819.1 - 0.013 15.1 0.9 0.051 13.2 0.6 1.9 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Mitofilin PF09731.4 KOO28819.1 - 0.69 8.4 11.5 0.79 8.3 8.0 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Herpes_gE PF02480.11 KOO28819.1 - 2.6 6.1 6.6 0.18 10.0 0.1 1.9 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E KH_1 PF00013.24 KOO28820.1 - 2.6e-05 23.7 0.3 4.7e-05 22.9 0.2 1.4 1 0 0 1 1 1 1 KH domain KCNQC3-Ank-G_bd PF11956.3 KOO28820.1 - 0.051 13.6 0.1 0.13 12.3 0.1 1.6 1 0 0 1 1 1 0 Ankyrin-G binding motif of KCNQ2-3 RRM_1 PF00076.17 KOO28821.1 - 4.7e-14 51.7 0.0 6.5e-14 51.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO28821.1 - 4e-10 39.3 0.0 5.8e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO28821.1 - 1.9e-09 37.3 0.0 2.9e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) NT-C2 PF10358.4 KOO28822.1 - 1e-07 31.5 0.0 1.5e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins PH_11 PF15413.1 KOO28822.1 - 0.014 15.6 0.2 20 5.4 0.0 3.2 3 0 0 3 3 3 0 Pleckstrin homology domain PH PF00169.24 KOO28822.1 - 0.014 15.5 0.0 0.03 14.5 0.0 1.6 1 0 0 1 1 1 0 PH domain zf-C4H2 PF10146.4 KOO28822.1 - 0.26 11.2 0.0 0.51 10.3 0.0 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein EF-hand_1 PF00036.27 KOO28823.1 - 1.5e-41 136.5 12.1 4.7e-10 38.0 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO28823.1 - 4e-37 126.1 5.1 1.7e-20 72.8 0.6 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO28823.1 - 5.5e-34 115.5 10.4 7.2e-17 60.7 0.3 4.2 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO28823.1 - 2e-29 98.8 8.2 2.3e-09 36.3 0.1 4.9 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.1 KOO28823.1 - 7.7e-27 91.4 7.9 5.4e-07 28.6 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.1 KOO28823.1 - 1.4e-15 56.9 0.1 3.7e-08 33.1 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO28823.1 - 1.5e-10 41.0 0.1 0.00019 21.4 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO28823.1 - 2.2e-10 40.1 0.4 0.00021 20.9 0.1 2.5 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EFhand_Ca_insen PF08726.5 KOO28823.1 - 1.1e-05 25.3 0.9 6.7e-05 22.7 0.1 2.3 2 0 0 2 2 2 1 Ca2+ insensitive EF hand UPF0154 PF03672.8 KOO28823.1 - 1.9e-05 24.1 0.1 0.17 11.4 0.0 3.1 3 1 1 4 4 4 2 Uncharacterised protein family (UPF0154) TerB PF05099.8 KOO28823.1 - 0.0006 19.5 0.6 0.25 11.0 0.0 2.6 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.8 KOO28823.1 - 0.002 17.6 0.1 0.17 11.4 0.0 2.5 2 1 0 2 2 2 1 Caleosin related protein DUF1103 PF06513.6 KOO28823.1 - 0.013 14.9 2.8 0.017 14.5 1.6 1.4 1 1 0 1 1 1 0 Repeat of unknown function (DUF1103) EF-hand_like PF09279.6 KOO28823.1 - 0.017 15.0 1.0 0.38 10.8 0.1 2.9 2 1 0 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like RNA_pol_Rpb4 PF03874.11 KOO28823.1 - 0.052 13.5 3.5 1.3 9.0 0.1 2.7 3 1 0 3 3 3 0 RNA polymerase Rpb4 Toprim_2 PF13155.1 KOO28823.1 - 0.063 13.6 2.3 8.7 6.7 0.0 2.8 2 1 0 3 3 3 0 Toprim-like MotA_activ PF09114.5 KOO28823.1 - 0.12 12.1 0.2 16 5.3 0.0 2.4 2 0 0 2 2 2 0 Transcription factor MotA, activation domain Kinase-PPPase PF03618.9 KOO28824.1 - 0.06 12.8 0.0 0.082 12.3 0.0 1.1 1 0 0 1 1 1 0 Kinase/pyrophosphorylase ASCH PF04266.9 KOO28824.1 - 0.084 13.2 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 ASCH domain Orai-1 PF07856.7 KOO28825.1 - 0.07 12.7 0.3 0.12 11.9 0.0 1.5 2 0 0 2 2 2 0 Mediator of CRAC channel activity Peptidase_M14 PF00246.19 KOO28826.1 - 8.7e-09 35.3 0.0 1.3e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase DUF2817 PF10994.3 KOO28826.1 - 5.8e-06 25.6 0.0 1e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2817) AstE_AspA PF04952.9 KOO28826.1 - 3.8e-05 22.7 0.0 5.5e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family Tubulin PF00091.20 KOO28827.1 - 1.2e-64 218.0 0.0 1.8e-64 217.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 KOO28827.1 - 3.3e-24 85.3 0.0 7.7e-24 84.1 0.0 1.6 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 KOO28827.1 - 0.021 14.8 0.0 0.041 13.9 0.0 1.5 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain DUF1411 PF07199.6 KOO28828.1 - 0.048 13.1 0.2 0.13 11.7 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1411) RNA_pol_3_Rpc31 PF11705.3 KOO28829.1 - 0.21 11.5 5.5 0.3 11.0 3.8 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Daxx PF03344.10 KOO28829.1 - 1.8 6.9 7.9 2.8 6.3 5.5 1.2 1 0 0 1 1 1 0 Daxx Family MMS22L_N PF14910.1 KOO28830.1 - 0.026 12.7 0.0 0.038 12.2 0.0 1.1 1 0 0 1 1 1 0 S-phase genomic integrity recombination mediator, N-terminal La PF05383.12 KOO28831.1 - 1.9e-21 75.5 0.0 1.2e-11 44.2 0.0 2.4 2 0 0 2 2 2 2 La domain Exo_endo_phos PF03372.18 KOO28831.1 - 1e-19 71.4 0.0 1.5e-19 70.9 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Cupin_8 PF13621.1 KOO28832.1 - 1.6e-25 90.1 0.0 2e-25 89.7 0.0 1.0 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 KOO28832.1 - 5.5e-08 32.4 0.0 1.7e-07 30.8 0.0 1.7 1 1 0 1 1 1 1 Cupin superfamily protein Cupin_2 PF07883.6 KOO28832.1 - 0.0024 17.3 0.0 0.0044 16.4 0.0 1.4 1 0 0 1 1 1 1 Cupin domain 2OG-FeII_Oxy_5 PF13759.1 KOO28832.1 - 0.044 14.0 0.0 0.082 13.1 0.0 1.4 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase Cupin_3 PF05899.7 KOO28832.1 - 0.051 12.9 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF861) JmjC PF02373.17 KOO28832.1 - 0.093 12.9 0.0 0.16 12.2 0.0 1.6 1 1 0 1 1 1 0 JmjC domain, hydroxylase Peptidase_C48 PF02902.14 KOO28833.1 - 2.4e-23 82.8 0.2 4e-23 82.1 0.2 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain HSP70 PF00012.15 KOO28834.1 - 2.2e-242 805.3 14.3 5.9e-188 625.5 0.1 2.0 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 KOO28834.1 - 7.9e-14 50.9 0.6 1.3e-11 43.6 0.0 2.6 1 1 1 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.11 KOO28834.1 - 0.011 15.4 0.0 0.042 13.4 0.0 2.1 2 1 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.1 KOO28834.1 - 0.03 14.1 8.1 0.54 10.1 0.1 4.7 3 1 0 3 3 3 0 Cell division protein FtsA Bap31 PF05529.7 KOO28834.1 - 8.2 5.8 5.4 17 4.8 3.8 1.5 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like CAF-1_p150 PF11600.3 KOO28835.1 - 0.17 11.2 22.5 0.19 11.0 15.6 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Atg14 PF10186.4 KOO28835.1 - 0.24 10.2 11.7 0.27 10.1 8.1 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Fumble PF03630.9 KOO28835.1 - 0.33 9.7 3.8 0.41 9.4 2.6 1.0 1 0 0 1 1 1 0 Fumble Asp-B-Hydro_N PF05279.6 KOO28835.1 - 5.3 6.8 11.9 5.8 6.6 8.2 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region zf-CCHC PF00098.18 KOO28837.1 - 0.0066 16.3 0.2 0.013 15.4 0.1 1.5 1 0 0 1 1 1 1 Zinc knuckle Apelin PF15360.1 KOO28839.1 - 0.09 13.0 0.5 0.2 11.9 0.4 1.6 1 0 0 1 1 1 0 APJ endogenous ligand Ribosomal_L24e PF01246.15 KOO28840.1 - 2.4e-27 94.5 1.8 5.7e-27 93.3 1.2 1.6 1 0 0 1 1 1 1 Ribosomal protein L24e NAD_Gly3P_dh_N PF01210.18 KOO28840.1 - 0.0079 15.9 0.2 0.011 15.4 0.1 1.2 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DUF3330 PF11809.3 KOO28840.1 - 0.07 13.0 0.1 0.19 11.6 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3330) DUF2175 PF09943.4 KOO28840.1 - 1.5 8.9 5.5 0.35 10.9 0.3 2.3 1 1 2 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) HAMP PF00672.20 KOO28841.1 - 2.4 8.4 5.9 8.8 6.5 4.1 1.9 1 1 0 1 1 1 0 HAMP domain Peptidase_C65 PF10275.4 KOO28842.1 - 3.1e-15 56.1 0.0 4.9e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase C65 Otubain 2OG-FeII_Oxy_3 PF13640.1 KOO28842.1 - 6e-06 26.6 0.0 1.4e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO28842.1 - 0.005 17.0 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Imm15 PF15590.1 KOO28842.1 - 0.04 13.0 0.0 0.1 11.6 0.0 1.7 1 0 0 1 1 1 0 Immunity protein 15 DNA_repr_REX1B PF14966.1 KOO28843.1 - 6.2e-12 45.7 1.1 8.3e-12 45.3 0.2 1.5 2 0 0 2 2 2 1 DNA repair REX1-B Virulence_fact PF13769.1 KOO28843.1 - 0.053 13.4 0.1 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Virulence factor MmoB_DmpM PF02406.12 KOO28843.1 - 0.056 13.4 0.1 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 MmoB/DmpM family NUDIX PF00293.23 KOO28844.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 NUDIX domain SpaB_C PF14028.1 KOO28845.1 - 0.082 12.4 4.2 0.09 12.3 2.9 1.2 1 0 0 1 1 1 0 SpaB C-terminal domain HXXSHH PF07586.6 KOO28845.1 - 0.23 10.3 2.2 0.41 9.5 1.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) Cgr1 PF03879.9 KOO28845.1 - 0.37 10.9 5.6 0.73 10.0 3.9 1.5 1 1 0 1 1 1 0 Cgr1 family CK2S PF15011.1 KOO28845.1 - 0.98 9.1 6.7 4.9 6.9 1.0 2.7 2 1 1 3 3 3 0 Casein Kinase 2 substrate SAM_2 PF07647.12 KOO28846.1 - 2.6e-05 23.9 0.0 8.7e-05 22.2 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 KOO28846.1 - 0.0006 19.9 0.0 0.0014 18.7 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Cyclin PF08613.6 KOO28846.1 - 0.00066 20.1 0.0 0.19 12.1 0.0 2.3 1 1 1 2 2 2 2 Cyclin Cyclin_N PF00134.18 KOO28846.1 - 0.0023 17.5 0.1 0.0048 16.4 0.1 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain KaiC PF06745.8 KOO28849.1 - 0.16 11.0 0.5 0.59 9.2 0.1 2.0 2 0 0 2 2 2 0 KaiC Baculo_PEP_C PF04513.7 KOO28849.1 - 0.23 11.2 3.4 21 4.9 0.0 3.4 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Phage_GP20 PF06810.6 KOO28849.1 - 0.48 9.8 2.9 0.53 9.7 0.4 2.3 1 1 1 2 2 2 0 Phage minor structural protein GP20 Phage_Mu_Gam PF07352.7 KOO28849.1 - 0.53 9.7 3.8 0.4 10.1 0.7 2.2 2 1 0 2 2 2 0 Bacteriophage Mu Gam like protein Tropomyosin_1 PF12718.2 KOO28849.1 - 2 8.2 25.9 0.41 10.4 5.0 3.6 1 1 2 4 4 4 0 Tropomyosin like CorA PF01544.13 KOO28849.1 - 2.4 7.1 9.3 5.6 5.9 2.3 2.2 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein TF_Otx PF03529.8 KOO28850.1 - 0.36 11.0 4.5 2.1 8.6 2.7 2.5 2 1 0 2 2 2 0 Otx1 transcription factor F420_oxidored PF03807.12 KOO28851.1 - 2.2e-07 31.1 0.3 5.3e-07 29.9 0.2 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Rossmann-like PF10727.4 KOO28851.1 - 0.00032 20.4 0.5 0.00072 19.2 0.3 1.6 1 0 0 1 1 1 1 Rossmann-like domain NAD_binding_2 PF03446.10 KOO28851.1 - 0.00057 19.7 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.11 KOO28851.1 - 0.00066 19.1 0.2 0.0011 18.4 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.14 KOO28851.1 - 0.0032 16.6 0.0 0.0067 15.6 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SIR2 PF02146.12 KOO28852.1 - 3.6e-30 104.9 0.0 6.2e-30 104.2 0.0 1.4 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.17 KOO28852.1 - 3.1e-05 23.7 0.0 0.21 11.3 0.0 2.5 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain Filo_VP35 PF02097.10 KOO28852.1 - 0.73 8.9 4.3 6.5 5.8 0.3 2.1 2 0 0 2 2 2 0 Filoviridae VP35 APG6 PF04111.7 KOO28852.1 - 6.8 5.6 5.9 11 4.9 4.1 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 WGG PF10273.4 KOO28854.1 - 0.38 10.8 1.0 0.93 9.6 0.0 2.2 2 0 0 2 2 2 0 Pre-rRNA-processing protein TSR2 rve PF00665.21 KOO28856.1 - 3.8e-08 33.4 0.0 1.5e-07 31.5 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain RVT_2 PF07727.9 KOO28856.1 - 1.3e-06 27.5 0.0 3.5e-06 26.1 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) GHL13 PF14883.1 KOO28857.1 - 0.046 12.8 0.1 0.067 12.3 0.1 1.1 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 13 PX PF00787.19 KOO28858.1 - 1.7e-22 79.3 0.0 4.2e-22 78.0 0.0 1.7 1 0 0 1 1 1 1 PX domain Vps5 PF09325.5 KOO28858.1 - 4.4e-09 35.9 2.2 1.9e-08 33.8 0.7 2.1 2 0 0 2 2 2 1 Vps5 C terminal like Med9 PF07544.8 KOO28858.1 - 0.026 14.2 7.1 0.11 12.3 0.0 3.4 3 1 1 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 SlyX PF04102.7 KOO28858.1 - 0.64 10.4 3.9 27 5.2 0.3 3.1 3 0 0 3 3 3 0 SlyX FlxA PF14282.1 KOO28858.1 - 5.6 6.9 8.9 17 5.4 3.1 2.8 2 1 1 3 3 3 0 FlxA-like protein CBFD_NFYB_HMF PF00808.18 KOO28859.1 - 9.7e-16 57.5 0.7 9.7e-16 57.5 0.5 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 KOO28859.1 - 1.7e-05 24.8 0.2 3.1e-05 23.9 0.1 1.5 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.11 KOO28859.1 - 0.0073 16.0 0.1 0.016 15.0 0.1 1.7 1 1 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit bZIP_1 PF00170.16 KOO28861.1 - 0.036 14.0 1.1 0.079 12.9 0.8 1.5 1 0 0 1 1 1 0 bZIP transcription factor Adenine_glyco PF03352.8 KOO28862.1 - 1.4e-56 190.8 0.0 2.1e-56 190.2 0.0 1.2 1 0 0 1 1 1 1 Methyladenine glycosylase zf-RING_2 PF13639.1 KOO28863.1 - 9.1e-12 44.6 4.8 1.4e-11 44.0 3.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 KOO28863.1 - 3.7e-07 30.0 3.5 5.7e-07 29.4 2.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO28863.1 - 8.8e-07 28.4 2.4 1.3e-06 27.9 1.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 KOO28863.1 - 4.5e-06 26.6 6.2 1.2e-05 25.2 4.3 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 KOO28863.1 - 2.7e-05 23.7 2.7 4.1e-05 23.2 1.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 KOO28863.1 - 3.4e-05 23.4 2.0 5.4e-05 22.7 1.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 KOO28863.1 - 0.032 14.0 4.9 0.11 12.3 3.3 1.8 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-HC5HC2H PF13771.1 KOO28863.1 - 0.068 13.3 0.7 0.12 12.5 0.5 1.4 1 0 0 1 1 1 0 PHD-like zinc-binding domain Baculo_RING PF05883.6 KOO28863.1 - 0.069 12.9 0.2 0.1 12.4 0.1 1.4 1 1 0 1 1 1 0 Baculovirus U-box/Ring-like domain zf-RING_UBOX PF13445.1 KOO28863.1 - 0.092 12.4 0.2 0.18 11.5 0.2 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-Nse PF11789.3 KOO28863.1 - 0.098 12.1 1.7 0.22 11.0 1.2 1.7 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit RINGv PF12906.2 KOO28863.1 - 0.16 12.0 3.0 0.51 10.4 2.1 1.8 1 1 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.1 KOO28863.1 - 0.19 11.3 4.8 14 5.4 3.3 2.3 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.6 KOO28863.1 - 0.86 9.6 5.1 1.4 8.9 3.6 1.4 1 0 0 1 1 1 0 RING-like domain Prok-RING_4 PF14447.1 KOO28863.1 - 1.4 8.5 5.7 17 5.0 3.8 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 FANCL_C PF11793.3 KOO28863.1 - 4.7 7.2 7.1 28 4.7 5.0 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain Oxysterol_BP PF01237.13 KOO28864.1 - 0.25 9.7 1.8 0.4 9.1 1.2 1.3 1 0 0 1 1 1 0 Oxysterol-binding protein adh_short PF00106.20 KOO28865.1 - 6.3e-09 35.9 0.0 1.1e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KOO28865.1 - 0.0048 16.6 0.0 0.0068 16.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase CAP_N PF01213.14 KOO28866.1 - 1.9 7.7 8.5 0.72 9.0 2.5 2.0 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Myb_DNA-binding PF00249.26 KOO28867.1 - 2.5e-07 30.6 2.0 3.7e-07 30.0 0.1 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO28867.1 - 4.9e-06 26.5 0.0 1.2e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain WD40 PF00400.27 KOO28868.1 - 2e-46 154.2 17.1 5.8e-10 38.6 0.1 7.4 7 1 0 7 7 7 7 WD domain, G-beta repeat PQQ_3 PF13570.1 KOO28868.1 - 1.3e-05 25.2 2.3 0.1 12.8 0.0 5.1 5 0 0 5 5 5 1 PQQ-like domain PQQ_2 PF13360.1 KOO28868.1 - 6.7e-05 22.4 0.7 0.043 13.2 0.0 2.5 1 1 0 2 2 2 2 PQQ-like domain Nup160 PF11715.3 KOO28868.1 - 0.19 9.8 4.8 3.1 5.8 0.2 3.4 1 1 2 4 4 4 0 Nucleoporin Nup120/160 AMP-binding PF00501.23 KOO28871.1 - 1.3e-75 254.4 0.0 2e-75 253.7 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme PPR_2 PF13041.1 KOO28872.1 - 3.9e-120 391.7 0.1 2.4e-12 46.6 0.0 12.7 2 2 11 13 13 13 13 PPR repeat family PPR_1 PF12854.2 KOO28872.1 - 7.8e-87 284.4 0.0 3.8e-09 35.8 0.0 14.2 14 0 0 14 14 14 13 PPR repeat PPR_3 PF13812.1 KOO28872.1 - 7.7e-81 259.7 23.4 1.4e-06 28.1 0.0 14.2 14 0 0 14 14 14 12 Pentatricopeptide repeat domain PPR PF01535.15 KOO28872.1 - 1.3e-75 244.2 1.1 1.7e-08 33.8 0.0 13.4 14 0 0 14 14 13 12 PPR repeat TPR_19 PF14559.1 KOO28872.1 - 1.3e-12 47.8 11.1 0.0012 19.1 0.1 5.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28872.1 - 3.3e-10 39.6 51.2 0.32 11.7 0.0 11.8 5 3 8 13 13 12 4 Tetratricopeptide repeat DUF3368 PF11848.3 KOO28872.1 - 1e-07 31.3 0.0 0.048 13.2 0.0 4.9 5 0 0 5 5 5 2 Domain of unknown function (DUF3368) TPR_12 PF13424.1 KOO28872.1 - 1.1e-06 28.5 15.2 0.055 13.4 0.0 7.1 5 1 4 9 9 9 3 Tetratricopeptide repeat DUF849 PF05853.7 KOO28872.1 - 4.1e-06 25.8 0.6 0.053 12.3 0.0 4.8 1 1 3 5 5 5 1 Prokaryotic protein of unknown function (DUF849) TPR_16 PF13432.1 KOO28872.1 - 0.00015 22.2 38.3 0.0065 17.1 0.6 7.3 8 1 1 9 9 9 3 Tetratricopeptide repeat TPR_4 PF07721.9 KOO28872.1 - 0.00018 21.5 61.7 1.3 9.6 0.3 11.0 11 0 0 11 11 11 6 Tetratricopeptide repeat Apc3 PF12895.2 KOO28872.1 - 0.0002 21.4 0.6 9.9 6.3 0.0 3.9 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 ECSIT PF06239.6 KOO28872.1 - 0.00027 19.8 0.0 0.87 8.4 0.0 4.9 5 1 1 6 6 6 1 Evolutionarily conserved signalling intermediate in Toll pathway SPOB_a PF14689.1 KOO28872.1 - 0.0032 17.0 0.0 6.5 6.3 0.0 4.3 5 0 0 5 5 5 1 Sensor_kinase_SpoOB-type, alpha-helical domain SelB-wing_2 PF09106.6 KOO28872.1 - 0.0088 15.9 0.5 1.3 9.0 0.0 4.2 5 0 0 5 5 4 1 Elongation factor SelB, winged helix Clathrin PF00637.15 KOO28872.1 - 0.022 14.3 0.0 12 5.4 0.0 3.5 2 2 3 5 5 5 0 Region in Clathrin and VPS TetR_C_9 PF14514.1 KOO28872.1 - 0.11 12.3 0.1 21 4.9 0.0 3.0 2 1 1 3 3 3 0 Transcriptional regulator, TetR, C-terminal TPR_7 PF13176.1 KOO28872.1 - 0.24 11.2 11.9 53 3.9 0.0 6.7 8 1 0 8 8 7 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO28872.1 - 0.62 10.1 14.3 33 4.7 0.1 7.4 8 0 0 8 8 7 0 Tetratricopeptide repeat Cytochrom_B_N PF00033.14 KOO28873.1 - 3.5e-19 68.9 10.5 4.3e-19 68.6 7.3 1.1 1 0 0 1 1 1 1 Cytochrome b(N-terminal)/b6/petB Ni_hydr_CYTB PF01292.15 KOO28873.1 - 1.8e-17 63.3 9.5 2.1e-17 63.0 6.6 1.1 1 0 0 1 1 1 1 Prokaryotic cytochrome b561 Ferric_reduct PF01794.14 KOO28873.1 - 0.032 14.3 3.3 0.4 10.7 0.1 2.4 2 0 0 2 2 2 0 Ferric reductase like transmembrane component Ubiq_cyt_C_chap PF03981.7 KOO28875.1 - 6.4e-13 48.7 0.0 1e-12 48.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone AAA PF00004.24 KOO28878.1 - 1.1e-33 116.2 0.1 3.5e-15 56.3 0.0 3.0 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOO28878.1 - 6.9e-13 48.8 3.4 0.002 18.2 0.1 5.4 4 2 1 5 5 4 2 AAA domain RuvB_N PF05496.7 KOO28878.1 - 6.2e-11 41.7 2.7 0.0002 20.4 0.1 3.4 2 2 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 KOO28878.1 - 1.4e-10 41.0 0.2 0.00036 20.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 KOO28878.1 - 2e-09 38.2 0.0 0.00017 22.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 KOO28878.1 - 3.6e-08 33.6 2.0 0.0073 16.3 0.0 3.4 2 1 0 2 2 2 2 AAA ATPase domain AAA_18 PF13238.1 KOO28878.1 - 6.9e-08 32.8 0.1 0.0022 18.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 KOO28878.1 - 9.7e-08 31.6 5.1 0.0016 18.1 0.1 4.0 4 0 0 4 4 4 2 Part of AAA domain Mg_chelatase PF01078.16 KOO28878.1 - 3.3e-07 29.6 4.7 0.014 14.6 0.1 3.8 2 2 2 4 4 4 2 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 KOO28878.1 - 2.3e-06 27.1 1.1 0.38 10.2 0.1 4.0 2 2 0 2 2 2 2 Sigma-54 interaction domain DUF815 PF05673.8 KOO28878.1 - 1.4e-05 24.1 1.9 0.14 11.0 0.0 3.9 4 1 1 5 5 5 2 Protein of unknown function (DUF815) Sigma54_activ_2 PF14532.1 KOO28878.1 - 1.6e-05 24.9 0.0 0.1 12.6 0.0 2.9 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_30 PF13604.1 KOO28878.1 - 1.6e-05 24.5 1.0 0.013 15.0 0.2 3.0 2 1 0 2 2 2 1 AAA domain Torsin PF06309.6 KOO28878.1 - 6.6e-05 22.8 0.1 0.25 11.2 0.0 2.7 2 1 0 2 2 2 2 Torsin CAP_GLY PF01302.20 KOO28878.1 - 7.4e-05 22.3 0.0 0.00013 21.6 0.0 1.4 1 0 0 1 1 1 1 CAP-Gly domain AAA_2 PF07724.9 KOO28878.1 - 0.00011 22.1 0.1 0.52 10.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.1 KOO28878.1 - 0.00018 21.4 0.3 0.26 11.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain KTI12 PF08433.5 KOO28878.1 - 0.00018 20.7 0.1 0.1 11.7 0.0 2.3 2 0 0 2 2 2 1 Chromatin associated protein KTI12 Viral_helicase1 PF01443.13 KOO28878.1 - 0.00021 20.8 0.0 0.14 11.6 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.1 KOO28878.1 - 0.00023 21.1 0.4 0.089 12.7 0.0 3.2 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 KOO28878.1 - 0.00023 21.2 0.1 0.24 11.5 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_3 PF07726.6 KOO28878.1 - 0.00032 20.3 0.2 0.63 9.6 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.4 KOO28878.1 - 0.00035 19.6 1.1 0.65 8.9 0.1 3.0 2 2 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) TrwB_AAD_bind PF10412.4 KOO28878.1 - 0.00041 19.1 0.2 0.32 9.5 0.0 2.4 2 0 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain NTPase_1 PF03266.10 KOO28878.1 - 0.00061 19.5 0.3 0.61 9.7 0.0 2.9 3 0 0 3 3 3 1 NTPase Zeta_toxin PF06414.7 KOO28878.1 - 0.00071 18.7 0.1 0.51 9.3 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin AAA_11 PF13086.1 KOO28878.1 - 0.0033 17.0 0.0 4 6.9 0.0 2.4 1 1 0 2 2 2 0 AAA domain AAA_24 PF13479.1 KOO28878.1 - 0.0035 16.9 0.0 4.5 6.7 0.0 2.9 3 0 0 3 3 3 0 AAA domain MCM PF00493.18 KOO28878.1 - 0.004 15.9 2.0 0.2 10.4 0.0 2.7 3 0 0 3 3 3 1 MCM2/3/5 family APS_kinase PF01583.15 KOO28878.1 - 0.0044 16.7 0.3 2.1 7.9 0.0 2.4 2 0 0 2 2 2 1 Adenylylsulphate kinase MobB PF03205.9 KOO28878.1 - 0.0053 16.4 0.1 1.3 8.7 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Parvo_NS1 PF01057.12 KOO28878.1 - 0.0054 15.6 0.0 1.1 8.0 0.0 2.3 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 FtsK_SpoIIIE PF01580.13 KOO28878.1 - 0.0057 16.1 0.0 3.6 7.0 0.0 2.8 3 0 0 3 3 2 0 FtsK/SpoIIIE family SKI PF01202.17 KOO28878.1 - 0.0064 16.3 0.6 1.1 9.0 0.0 2.8 2 0 0 2 2 2 1 Shikimate kinase DUF3987 PF13148.1 KOO28878.1 - 0.018 13.5 0.4 9.6 4.6 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3987) ABC_tran PF00005.22 KOO28878.1 - 0.023 14.9 0.1 7.9 6.7 0.0 2.4 2 0 0 2 2 2 0 ABC transporter AAA_10 PF12846.2 KOO28878.1 - 0.046 13.1 5.4 5.2 6.3 0.1 4.3 3 2 2 5 5 5 0 AAA-like domain IstB_IS21 PF01695.12 KOO28878.1 - 0.046 13.1 0.1 8.2 5.8 0.0 2.7 2 0 0 2 2 2 0 IstB-like ATP binding protein Zot PF05707.7 KOO28878.1 - 0.056 12.9 0.4 28 4.0 0.0 3.6 2 2 0 2 2 2 0 Zonular occludens toxin (Zot) TetR PF13972.1 KOO28878.1 - 0.058 12.8 0.0 0.16 11.3 0.0 1.8 1 0 0 1 1 1 0 Bacterial transcriptional repressor CbiA PF01656.18 KOO28878.1 - 0.062 12.6 0.4 0.2 11.0 0.0 2.1 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain ADK PF00406.17 KOO28878.1 - 0.068 13.0 0.4 1.1 9.1 0.0 2.6 2 0 0 2 2 2 0 Adenylate kinase NACHT PF05729.7 KOO28878.1 - 0.075 12.6 2.3 1.9 8.1 0.1 3.1 3 0 0 3 3 3 0 NACHT domain Thymidylate_kin PF02223.12 KOO28878.1 - 0.12 11.7 0.2 3.8 6.8 0.0 2.3 2 0 0 2 2 2 0 Thymidylate kinase TIP49 PF06068.8 KOO28878.1 - 0.21 10.2 1.1 58 2.2 0.0 3.9 4 1 0 5 5 5 0 TIP49 C-terminus AAA_25 PF13481.1 KOO28878.1 - 0.57 9.5 5.2 5.3 6.3 0.2 3.8 4 2 1 5 5 3 0 AAA domain Metallophos_2 PF12850.2 KOO28879.1 - 2.9e-22 79.1 0.0 3.5e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 KOO28879.1 - 3.7e-06 26.4 2.0 0.00041 19.7 1.4 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase CorA PF01544.13 KOO28880.1 - 0.0017 17.4 1.4 0.0055 15.7 0.1 2.2 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein DUF2721 PF11026.3 KOO28880.1 - 0.0089 15.6 0.7 0.021 14.4 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2721) Tmemb_cc2 PF10267.4 KOO28880.1 - 0.019 13.5 0.1 0.033 12.8 0.1 1.3 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein ABC_membrane PF00664.18 KOO28881.1 - 2.1e-39 135.5 2.2 3e-39 135.1 1.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 KOO28881.1 - 2e-31 109.1 0.0 3.3e-31 108.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 KOO28881.1 - 1.8e-05 24.0 0.0 0.00011 21.4 0.0 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.1 KOO28881.1 - 0.02 14.7 1.3 0.093 12.6 0.2 2.5 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.1 KOO28881.1 - 0.039 13.4 0.0 0.1 12.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.1 KOO28881.1 - 0.13 12.2 0.0 22 4.8 0.0 2.2 1 1 0 2 2 2 0 AAA domain CLP_protease PF00574.18 KOO28883.1 - 2.7e-51 173.8 0.0 4e-51 173.2 0.0 1.2 1 0 0 1 1 1 1 Clp protease Peptidase_S49 PF01343.13 KOO28883.1 - 0.022 14.5 0.2 1.4 8.6 0.0 2.2 2 0 0 2 2 2 0 Peptidase family S49 PTPS_related PF10131.4 KOO28884.1 - 0.071 11.2 0.6 0.092 10.8 0.4 1.0 1 0 0 1 1 1 0 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein SET PF00856.23 KOO28885.1 - 5.9e-11 42.9 0.0 9.1e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 SET domain WD40 PF00400.27 KOO28886.1 - 8.1e-81 263.2 30.0 1.4e-11 43.7 0.2 8.4 8 0 0 8 8 8 7 WD domain, G-beta repeat Dynamin_N PF00350.18 KOO28886.1 - 8.2e-18 64.7 0.0 1.4e-17 64.0 0.0 1.4 1 0 0 1 1 1 1 Dynamin family PD40 PF07676.7 KOO28886.1 - 1.1e-10 40.9 0.4 2.6 7.8 0.0 6.3 6 0 0 6 6 6 4 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOO28886.1 - 8.5e-10 38.6 0.1 0.0001 22.0 0.0 3.2 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Arm PF00514.18 KOO28886.1 - 9.1e-10 38.0 5.8 6.1e-05 22.6 0.3 5.0 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat BBS2_Mid PF14783.1 KOO28886.1 - 8.7e-09 35.1 0.5 0.013 15.2 0.0 4.2 1 1 2 4 4 4 3 Ciliary BBSome complex subunit 2, middle region TFIIIC_delta PF12657.2 KOO28886.1 - 2.4e-06 27.3 4.0 0.03 14.0 0.2 3.5 1 1 0 2 2 2 2 Transcription factor IIIC subunit delta N-term HEAT_2 PF13646.1 KOO28886.1 - 0.00016 21.8 23.0 0.00051 20.2 5.5 3.8 3 1 1 4 4 4 2 HEAT repeats U-box PF04564.10 KOO28886.1 - 0.00026 20.8 0.0 0.00058 19.7 0.0 1.6 1 0 0 1 1 1 1 U-box domain PHTB1_N PF14727.1 KOO28886.1 - 0.00034 19.6 0.4 0.36 9.7 0.0 3.6 2 2 2 4 4 4 1 PTHB1 N-terminus DUF3312 PF11768.3 KOO28886.1 - 0.00078 17.7 0.1 4.6 5.3 0.0 4.2 1 1 3 5 5 5 1 Protein of unknown function (DUF3312) HEAT PF02985.17 KOO28886.1 - 0.0021 18.0 0.0 0.0021 18.0 0.0 4.0 4 0 0 4 4 3 1 HEAT repeat MMR_HSR1 PF01926.18 KOO28886.1 - 0.017 15.0 0.0 0.12 12.3 0.0 2.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase Miro PF08477.8 KOO28886.1 - 0.018 15.5 0.1 0.38 11.2 0.0 3.2 3 1 1 4 4 4 0 Miro-like protein UCH PF00443.24 KOO28887.1 - 2.9e-29 101.9 0.0 1.4e-27 96.4 0.0 2.2 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.18 KOO28887.1 - 2e-10 39.9 0.1 6.1e-10 38.3 0.0 1.8 1 1 1 2 2 2 1 Ubiquitin family UCH_1 PF13423.1 KOO28887.1 - 2.2e-08 33.9 2.6 1.6e-07 31.1 0.8 2.4 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Rad60-SLD PF11976.3 KOO28887.1 - 0.013 15.1 0.0 0.027 14.1 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 KOO28887.1 - 0.15 12.3 0.0 0.41 10.9 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin-like domain FWWh PF14922.1 KOO28888.1 - 1.2e-11 44.3 0.0 1.6e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function EF-hand_6 PF13405.1 KOO28889.1 - 0.0023 17.6 0.1 0.077 12.9 0.0 3.0 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.27 KOO28889.1 - 0.26 10.6 0.0 0.26 10.6 0.0 2.5 3 0 0 3 3 3 0 EF hand Ank_2 PF12796.2 KOO28890.1 - 6.8e-16 58.3 0.8 3.1e-14 53.0 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO28890.1 - 1.3e-12 46.7 7.6 9e-06 25.2 0.0 5.3 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.1 KOO28890.1 - 3.8e-12 46.3 0.8 2.9e-08 34.0 0.0 3.4 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO28890.1 - 4.6e-12 44.9 1.8 0.00077 19.4 0.0 4.8 4 1 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.1 KOO28890.1 - 1e-05 25.5 4.1 0.0026 17.9 0.1 4.5 3 2 2 5 5 5 2 Ankyrin repeats (many copies) EF-hand_6 PF13405.1 KOO28891.1 - 5.8e-13 47.5 2.7 0.01 15.6 0.0 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.27 KOO28891.1 - 1.7e-12 45.6 1.9 0.084 12.2 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO28891.1 - 3.6e-12 46.2 6.8 1.3e-07 31.6 0.4 3.4 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO28891.1 - 1.5e-06 27.3 6.5 0.078 12.3 0.1 4.1 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO28891.1 - 1e-05 25.0 5.4 0.041 13.4 0.1 3.8 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.1 KOO28891.1 - 0.034 14.0 0.0 0.92 9.4 0.0 2.7 3 0 0 3 3 3 0 EF-hand domain Cob_adeno_trans PF01923.13 KOO28892.1 - 2.5e-49 167.2 0.0 3.6e-49 166.6 0.0 1.2 1 1 0 1 1 1 1 Cobalamin adenosyltransferase Ceramidase PF05875.7 KOO28893.1 - 5.7e-16 58.4 3.6 7.8e-16 57.9 2.5 1.2 1 0 0 1 1 1 1 Ceramidase MMR_HSR1 PF01926.18 KOO28894.1 - 5.7e-20 71.4 0.0 1.2e-19 70.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP-bdg_N PF13167.1 KOO28894.1 - 1.5e-15 57.0 0.0 3e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 GTP-binding GTPase N-terminal GTP_EFTU PF00009.22 KOO28894.1 - 0.00014 21.4 0.0 0.26 10.7 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 KOO28894.1 - 0.00015 21.6 0.2 0.013 15.3 0.0 2.3 2 0 0 2 2 2 1 Dynamin family cobW PF02492.14 KOO28894.1 - 0.00034 20.1 3.9 0.097 12.1 0.1 2.8 2 1 1 3 3 3 2 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.22 KOO28894.1 - 0.00043 20.5 0.0 0.0011 19.2 0.0 1.7 1 0 0 1 1 1 1 ABC transporter FeoB_N PF02421.13 KOO28894.1 - 0.00068 18.9 0.5 0.0026 17.0 0.3 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B Miro PF08477.8 KOO28894.1 - 0.0012 19.3 0.3 0.0052 17.2 0.1 2.1 2 1 0 2 2 1 1 Miro-like protein MobB PF03205.9 KOO28894.1 - 0.0062 16.2 0.1 0.014 15.1 0.1 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B Arf PF00025.16 KOO28894.1 - 0.011 14.9 0.1 3 7.0 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_16 PF13191.1 KOO28894.1 - 0.018 15.0 1.9 0.045 13.7 0.5 2.2 2 1 0 2 2 2 0 AAA ATPase domain DUF258 PF03193.11 KOO28894.1 - 0.027 13.6 0.0 0.047 12.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ArgK PF03308.11 KOO28894.1 - 0.036 12.8 0.3 0.4 9.4 0.0 2.3 1 1 1 2 2 2 0 ArgK protein AAA_23 PF13476.1 KOO28894.1 - 0.037 14.3 0.2 0.089 13.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 KOO28894.1 - 0.098 12.1 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_14 PF13173.1 KOO28894.1 - 0.1 12.5 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain GBP PF02263.14 KOO28894.1 - 0.16 10.9 0.0 0.26 10.2 0.0 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain EF-hand_7 PF13499.1 KOO28895.1 - 2.5e-32 110.8 0.5 1.5e-10 41.0 0.0 6.2 6 1 0 6 6 6 4 EF-hand domain pair EF-hand_1 PF00036.27 KOO28895.1 - 9.3e-32 105.8 11.5 4.8e-06 25.5 0.3 8.3 8 0 0 8 8 8 6 EF hand EF-hand_6 PF13405.1 KOO28895.1 - 1.8e-30 102.0 11.7 8.3e-06 25.2 0.1 8.4 9 0 0 9 9 9 6 EF-hand domain EF-hand_8 PF13833.1 KOO28895.1 - 7e-25 86.4 10.9 0.00055 19.4 0.0 8.1 8 1 1 9 9 9 5 EF-hand domain pair EF-hand_5 PF13202.1 KOO28895.1 - 1.8e-14 52.2 14.0 8e-05 21.8 0.3 6.7 6 0 0 6 6 6 5 EF hand EF-hand_10 PF14788.1 KOO28895.1 - 0.012 15.3 0.0 1.8 8.2 0.0 3.6 4 0 0 4 4 4 0 EF hand Asp-B-Hydro_N PF05279.6 KOO28895.1 - 0.052 13.3 0.1 0.052 13.3 0.1 2.1 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region WD40 PF00400.27 KOO28897.1 - 2.7e-66 217.2 19.8 1.3e-12 47.0 0.1 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat PD40 PF07676.7 KOO28897.1 - 2.3e-14 52.6 1.1 0.45 10.2 0.0 5.3 5 0 0 5 5 5 5 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOO28897.1 - 3.3e-12 46.5 1.2 0.00033 20.4 0.0 2.6 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.1 KOO28897.1 - 4.8e-07 29.1 1.6 0.35 9.9 0.1 3.8 1 1 3 4 4 4 3 Neuroblastoma-amplified sequence, N terminal BBS2_Mid PF14783.1 KOO28897.1 - 2.7e-06 27.1 0.2 0.019 14.7 0.0 3.9 1 1 1 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Dfp1_Him1_M PF08630.5 KOO28897.1 - 0.00016 21.4 0.4 3.8 7.3 0.0 3.9 4 0 0 4 4 4 2 Dfp1/Him1, central region Gmad1 PF10647.4 KOO28897.1 - 0.00065 19.1 0.1 50 3.1 0.0 4.6 2 2 0 5 5 5 0 Lipoprotein LpqB beta-propeller domain PQQ_3 PF13570.1 KOO28897.1 - 0.00095 19.3 2.4 11 6.3 0.0 4.5 5 0 0 5 5 5 0 PQQ-like domain TFIIIC_delta PF12657.2 KOO28897.1 - 0.0031 17.2 3.0 0.16 11.6 0.4 2.8 1 1 3 4 4 4 2 Transcription factor IIIC subunit delta N-term UN_NPL4 PF11543.3 KOO28897.1 - 0.021 15.0 1.1 1.3e+02 2.9 0.0 4.8 5 0 0 5 5 5 0 Nuclear pore localisation protein NPL4 IKI3 PF04762.7 KOO28897.1 - 0.023 12.5 0.2 0.11 10.3 0.1 2.0 1 1 0 1 1 1 0 IKI3 family ACT_4 PF13291.1 KOO28897.1 - 0.11 12.8 0.3 47 4.4 0.0 3.4 3 1 0 3 3 3 0 ACT domain DUF1844 PF08899.6 KOO28897.1 - 0.24 11.3 1.0 35 4.3 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF1844) XRN_N PF03159.13 KOO28898.1 - 3.1e-81 272.2 0.0 1.2e-40 139.4 0.0 2.1 1 1 1 2 2 2 2 XRN 5'-3' exonuclease N-terminus DUF3632 PF12311.3 KOO28899.1 - 0.012 15.4 0.5 0.15 11.8 0.2 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF3632) Ubiq_cyt_C_chap PF03981.7 KOO28899.1 - 0.054 13.3 3.4 0.064 13.1 0.4 2.2 2 0 0 2 2 2 0 Ubiquinol-cytochrome C chaperone HHH_5 PF14520.1 KOO28899.1 - 0.12 12.5 0.7 0.41 10.8 0.1 2.2 2 0 0 2 2 2 0 Helix-hairpin-helix domain RNase_T PF00929.19 KOO28900.1 - 0.023 15.0 0.0 0.027 14.7 0.0 1.1 1 0 0 1 1 1 0 Exonuclease EF-hand_1 PF00036.27 KOO28901.1 - 2.8e-27 91.8 8.4 1e-07 30.7 0.2 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO28901.1 - 1.6e-26 92.2 1.1 6.9e-12 45.3 0.8 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO28901.1 - 1e-23 82.6 5.4 1.7e-11 43.5 0.2 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO28901.1 - 6.3e-22 75.4 5.7 3.8e-07 29.4 0.2 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO28901.1 - 2.6e-18 64.4 10.1 2.3e-05 23.4 0.6 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.1 KOO28901.1 - 1e-05 25.3 0.0 0.0011 18.8 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO28901.1 - 0.00022 21.1 0.0 0.81 9.7 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO28901.1 - 0.00088 18.9 1.3 0.029 14.0 0.4 2.4 2 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand tRNA_synt_1c_R1 PF04558.10 KOO28901.1 - 0.003 17.1 0.4 1.3 8.5 0.1 2.2 1 1 1 2 2 2 2 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 UPF0154 PF03672.8 KOO28901.1 - 0.085 12.4 0.1 0.85 9.2 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) DUF1217 PF06748.7 KOO28901.1 - 0.11 12.5 0.1 0.19 11.7 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1217) EFhand_Ca_insen PF08726.5 KOO28901.1 - 0.13 12.2 0.0 0.45 10.5 0.0 1.9 2 0 0 2 2 2 0 Ca2+ insensitive EF hand Guanylate_cyc_2 PF09778.4 KOO28902.1 - 2e-45 154.6 0.0 2.3e-45 154.3 0.0 1.0 1 0 0 1 1 1 1 Guanylylate cyclase Transpep_BrtH PF14399.1 KOO28902.1 - 5.9e-06 25.7 0.0 8.5e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 NlpC/p60-like transpeptidase Peptidase_C39_2 PF13529.1 KOO28902.1 - 0.05 13.9 0.2 0.073 13.4 0.2 1.5 1 1 0 1 1 1 0 Peptidase_C39 like family Ank_2 PF12796.2 KOO28903.1 - 2.9e-58 194.1 13.4 1.7e-11 44.2 0.0 6.2 3 3 3 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.25 KOO28903.1 - 2.6e-53 175.2 21.8 1.3e-08 34.2 0.2 11.0 11 0 0 11 11 11 10 Ankyrin repeat Ank_4 PF13637.1 KOO28903.1 - 5.1e-42 141.5 5.9 1.4e-09 38.1 0.1 9.1 6 2 5 11 11 11 9 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO28903.1 - 6.8e-36 118.7 9.6 0.00018 21.4 0.0 10.5 11 0 0 11 11 11 6 Ankyrin repeat Ank_5 PF13857.1 KOO28903.1 - 2.8e-34 116.3 16.8 8.8e-08 32.1 0.1 7.6 5 3 3 8 8 8 7 Ankyrin repeats (many copies) JmjC PF02373.17 KOO28904.1 - 1.1e-06 28.8 0.0 1.9e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.1 KOO28904.1 - 0.00031 20.3 0.0 0.00054 19.5 0.0 1.4 1 1 0 1 1 1 1 Cupin-like domain F-box PF00646.28 KOO28905.1 - 0.00011 21.7 0.1 0.0002 20.8 0.1 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 KOO28905.1 - 0.0059 16.3 0.2 0.02 14.6 0.3 1.7 2 0 0 2 2 2 1 F-box-like FabA PF07977.8 KOO28906.1 - 1.9e-37 127.8 0.2 2.4e-37 127.4 0.1 1.1 1 0 0 1 1 1 1 FabA-like domain MaoC_dehydratas PF01575.14 KOO28906.1 - 0.012 14.9 0.1 0.026 13.9 0.1 1.6 1 0 0 1 1 1 0 MaoC like domain MaoC_dehydrat_N PF13452.1 KOO28906.1 - 0.12 12.1 0.0 0.38 10.5 0.0 1.9 2 0 0 2 2 2 0 N-terminal half of MaoC dehydratase Methyltransf_18 PF12847.2 KOO28907.1 - 2.6e-09 37.6 0.0 5.3e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO28907.1 - 3.9e-08 33.0 0.0 5.2e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 KOO28907.1 - 3.9e-07 29.4 0.0 5.9e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 KOO28907.1 - 6.4e-07 29.4 0.6 2e-06 27.8 0.4 1.9 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOO28907.1 - 6.8e-06 25.5 0.1 1.1e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PRMT5 PF05185.11 KOO28907.1 - 1.1e-05 24.5 0.0 1.5e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_11 PF08241.7 KOO28907.1 - 9e-05 22.8 0.0 0.00019 21.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO28907.1 - 0.00021 21.0 0.0 0.0004 20.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.1 KOO28907.1 - 0.0019 19.0 0.1 0.011 16.5 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.10 KOO28907.1 - 0.0034 16.8 0.1 0.0067 15.8 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_16 PF10294.4 KOO28907.1 - 0.0051 16.2 0.0 0.0084 15.5 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase TehB PF03848.9 KOO28907.1 - 0.022 13.9 0.0 0.044 12.9 0.0 1.6 1 1 0 1 1 1 0 Tellurite resistance protein TehB Met_10 PF02475.11 KOO28907.1 - 0.046 13.2 0.0 0.07 12.7 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein FtsJ PF01728.14 KOO28907.1 - 0.085 12.8 0.0 0.16 11.9 0.0 1.4 2 0 0 2 2 1 0 FtsJ-like methyltransferase DREV PF05219.7 KOO28907.1 - 0.21 10.4 0.0 0.3 9.8 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase ARL2_Bind_BART PF11527.3 KOO28909.1 - 6.9e-40 135.5 0.0 3.5e-28 97.8 0.0 2.6 2 1 0 2 2 2 2 The ARF-like 2 binding protein BART DUF4395 PF14340.1 KOO28909.1 - 0.081 12.9 0.2 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4395) Pkinase PF00069.20 KOO28911.1 - 1.4e-43 148.9 0.0 2.1e-43 148.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO28911.1 - 2.1e-22 79.4 0.0 3e-22 78.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO28911.1 - 1.8e-06 27.8 3.7 0.0001 22.1 0.1 2.8 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 KOO28911.1 - 0.04 12.9 0.0 0.07 12.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family NTP_transferase PF00483.18 KOO28911.1 - 0.048 12.9 0.0 0.078 12.2 0.0 1.3 1 0 0 1 1 1 0 Nucleotidyl transferase NAD_binding_2 PF03446.10 KOO28912.1 - 9.4e-37 126.3 0.1 1.6e-36 125.6 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 KOO28912.1 - 3.2e-20 72.3 3.6 5.4e-20 71.6 2.5 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.12 KOO28912.1 - 7.4e-06 26.3 0.0 3.8e-05 24.0 0.0 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.18 KOO28912.1 - 0.051 13.2 0.1 3.2 7.4 0.0 2.4 2 1 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus IF2_N PF04760.10 KOO28912.1 - 0.088 12.4 0.0 0.23 11.1 0.0 1.7 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region CRAL_TRIO PF00650.15 KOO28913.1 - 2.4e-21 75.8 0.0 3.9e-21 75.1 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain Amidohydro_1 PF01979.15 KOO28913.1 - 1.5 8.4 5.6 5.2 6.6 0.5 2.5 2 1 1 3 3 3 0 Amidohydrolase family Methyltransf_21 PF05050.7 KOO28914.1 - 2.2e-06 27.7 0.0 2.5e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_22 PF13383.1 KOO28914.1 - 0.00086 18.9 0.0 0.001 18.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ribosomal_L28 PF00830.14 KOO28915.1 - 3.2e-22 78.1 2.2 4.2e-22 77.7 1.5 1.1 1 0 0 1 1 1 1 Ribosomal L28 family CR6_interact PF10147.4 KOO28916.1 - 0.024 13.9 0.1 0.029 13.6 0.0 1.0 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Glyco_hydro_39 PF01229.12 KOO28918.1 - 2.2e-50 171.4 0.0 3e-37 128.1 0.0 3.0 2 1 1 3 3 3 3 Glycosyl hydrolases family 39 Cellulase-like PF12876.2 KOO28918.1 - 0.059 13.8 0.1 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 Sugar-binding cellulase-like Myotub-related PF06602.9 KOO28919.1 - 8.7e-120 399.7 0.1 1.2e-119 399.2 0.1 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.1 KOO28919.1 - 0.052 13.7 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family bZIP_2 PF07716.10 KOO28919.1 - 0.099 12.4 2.0 0.18 11.6 1.4 1.4 1 0 0 1 1 1 0 Basic region leucine zipper bZIP_1 PF00170.16 KOO28919.1 - 0.14 12.1 0.4 0.28 11.1 0.3 1.4 1 0 0 1 1 1 0 bZIP transcription factor DUF3138 PF11336.3 KOO28919.1 - 2.5 6.1 6.2 3.6 5.6 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Sulfate_transp PF00916.15 KOO28920.1 - 2.6e-53 180.8 16.9 2.6e-53 180.8 11.7 1.5 2 0 0 2 2 2 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 KOO28920.1 - 1.2e-24 85.8 6.7 1.2e-24 85.8 4.7 3.9 5 1 0 5 5 5 1 Sulfate transporter N-terminal domain with GLY motif PARP PF00644.15 KOO28921.1 - 3.1e-12 46.3 0.0 4.2e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PP2C PF00481.16 KOO28923.1 - 7.5e-33 113.9 0.0 1.3e-32 113.1 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 KOO28923.1 - 0.00023 20.6 2.1 0.0016 17.8 1.0 2.2 2 0 0 2 2 2 1 Protein phosphatase 2C tRNA_NucTransf2 PF09249.6 KOO28926.1 - 0.15 11.9 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 tRNA nucleotidyltransferase, second domain Metallophos_2 PF12850.2 KOO28927.1 - 2.5e-06 27.4 0.6 4.6e-06 26.5 0.4 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF2830 PF11125.3 KOO28928.1 - 0.076 12.7 0.1 0.28 10.9 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2830) PsaM PF07465.8 KOO28928.1 - 0.46 10.1 0.0 0.46 10.1 0.0 4.2 4 0 0 4 4 4 0 Photosystem I protein M (PsaM) CbtA PF09490.5 KOO28929.1 - 3.6e-36 124.5 12.5 7.8e-35 120.2 3.8 5.1 5 0 0 5 5 5 2 Probable cobalt transporter subunit (CbtA) GET2 PF08690.5 KOO28929.1 - 0.71 9.0 3.9 0.53 9.4 1.3 1.8 2 0 0 2 2 2 0 GET complex subunit GET2 Pyrophosphatase PF00719.14 KOO28930.1 - 1.2e-40 138.5 0.0 1.4e-40 138.3 0.0 1.0 1 0 0 1 1 1 1 Inorganic pyrophosphatase EF-hand_7 PF13499.1 KOO28931.1 - 4.4e-20 71.5 7.7 6.8e-10 38.9 2.4 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO28931.1 - 1.3e-19 67.9 12.1 4.9e-06 25.4 0.2 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO28931.1 - 1.3e-15 55.7 13.1 7.3e-06 25.4 0.3 4.4 3 1 1 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 KOO28931.1 - 1.3e-11 43.8 8.9 8.5e-05 22.0 0.3 4.3 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO28931.1 - 1.6e-11 42.9 13.5 0.00087 18.5 0.1 4.4 4 0 0 4 4 4 3 EF hand SPARC_Ca_bdg PF10591.4 KOO28931.1 - 0.00011 22.1 2.9 0.39 10.7 0.9 2.7 2 1 1 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO28931.1 - 0.14 11.8 3.9 1.2 8.8 0.2 3.2 3 2 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO28931.1 - 3.1 7.5 6.5 2.9 7.6 0.3 3.1 4 0 0 4 4 4 0 EF hand ChAPs PF09295.5 KOO28932.1 - 1.7e-19 69.9 0.0 4.4e-12 45.4 0.0 2.2 2 0 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_11 PF13414.1 KOO28932.1 - 1.8e-06 27.4 2.4 0.0014 18.2 0.1 3.7 2 1 1 3 3 3 2 TPR repeat TPR_19 PF14559.1 KOO28932.1 - 0.91 9.9 15.5 0.17 12.2 0.2 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat EGF_2 PF07974.8 KOO28934.1 - 6.5e-05 22.9 29.3 0.029 14.5 5.9 2.4 2 0 0 2 2 2 2 EGF-like domain Laminin_EGF PF00053.19 KOO28934.1 - 2.6 8.0 19.6 2.6 8.0 3.7 2.4 1 1 1 2 2 2 0 Laminin EGF-like (Domains III and V) Met_gamma_lyase PF06838.6 KOO28935.1 - 4.8e-144 479.6 0.0 5.5e-144 479.4 0.0 1.0 1 0 0 1 1 1 1 Methionine gamma-lyase Cys_Met_Meta_PP PF01053.15 KOO28935.1 - 9.8e-05 20.7 0.0 0.00014 20.3 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme HCBP_related PF06594.6 KOO28935.1 - 0.5 10.0 2.3 0.47 10.1 0.1 2.0 2 0 0 2 2 2 0 Haemolysin-type calcium binding protein related domain Kinesin PF00225.18 KOO28936.1 - 3.5e-108 361.2 0.1 4.9e-108 360.7 0.1 1.2 1 0 0 1 1 1 1 Kinesin motor domain Choline_transpo PF04515.7 KOO28937.1 - 2.1e-45 154.8 37.5 2.5e-45 154.6 22.9 2.1 2 0 0 2 2 2 2 Plasma-membrane choline transporter DUF4064 PF13273.1 KOO28937.1 - 0.02 14.9 2.9 0.02 14.9 2.0 4.5 2 2 2 4 4 4 0 Protein of unknown function (DUF4064) YfzA PF14118.1 KOO28937.1 - 9.2 6.4 7.9 22 5.2 0.2 3.0 3 0 0 3 3 3 0 YfzA-like protein PspC PF04024.7 KOO28938.1 - 0.11 12.0 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 PspC domain Nuc_sug_transp PF04142.10 KOO28939.1 - 1e-69 234.3 5.6 1.4e-69 233.8 3.9 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.6 KOO28939.1 - 3.7e-07 29.3 8.5 5.5e-07 28.7 5.9 1.2 1 0 0 1 1 1 1 UAA transporter family EmrE PF13536.1 KOO28939.1 - 5.8e-06 26.4 3.2 5.8e-06 26.4 2.2 2.7 2 2 0 2 2 2 1 Multidrug resistance efflux transporter EamA PF00892.15 KOO28939.1 - 2.9e-05 24.1 2.7 2.9e-05 24.1 1.9 3.1 2 1 0 2 2 2 1 EamA-like transporter family TPT PF03151.11 KOO28939.1 - 0.0029 17.2 6.0 0.0029 17.2 4.2 3.1 2 1 0 2 2 2 1 Triose-phosphate Transporter family SET PF00856.23 KOO28941.1 - 1.3e-25 90.6 0.0 3e-25 89.4 0.0 1.7 1 0 0 1 1 1 1 SET domain PHD PF00628.24 KOO28941.1 - 3.2e-14 52.3 32.4 1.1e-06 28.2 5.8 3.8 3 0 0 3 3 3 3 PHD-finger MBT PF02820.13 KOO28941.1 - 3.3e-07 30.1 0.1 5.3e-05 23.0 0.0 2.5 2 0 0 2 2 2 1 mbt repeat Tudor-knot PF11717.3 KOO28941.1 - 0.28 10.9 3.1 5.4 6.8 0.0 2.7 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain zf-HC5HC2H PF13771.1 KOO28941.1 - 4.1 7.6 45.8 0.078 13.1 4.7 4.1 3 1 1 4 4 4 0 PHD-like zinc-binding domain DUF4336 PF14234.1 KOO28942.1 - 4.9e-64 216.2 0.0 1.3e-42 145.9 0.0 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4336) PDZ PF00595.19 KOO28943.1 - 0.003 17.6 0.0 0.0056 16.8 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Mss4 PF04421.8 KOO28943.1 - 0.0088 15.8 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 Mss4 protein EF-hand_7 PF13499.1 KOO28944.1 - 9.2e-25 86.5 2.9 2.1e-11 43.7 0.3 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO28944.1 - 2.7e-23 79.4 4.3 0.00014 20.8 0.0 4.1 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO28944.1 - 3.6e-20 69.9 4.7 0.00039 20.0 0.0 4.1 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 KOO28944.1 - 1.6e-16 59.6 3.4 0.0058 16.2 0.0 4.1 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO28944.1 - 1.8e-15 55.4 3.2 0.019 14.3 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_10 PF14788.1 KOO28944.1 - 4.9e-05 22.9 0.9 5 6.8 0.1 4.0 4 0 0 4 4 4 2 EF hand Armet PF10208.4 KOO28944.1 - 0.00042 20.0 0.0 0.0019 17.8 0.0 2.0 1 1 1 2 2 2 1 Degradation arginine-rich protein for mis-folding SPARC_Ca_bdg PF10591.4 KOO28944.1 - 0.014 15.4 0.3 1.1 9.3 0.0 2.5 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO28944.1 - 0.083 12.6 3.2 4.9 6.9 0.0 3.2 1 1 3 4 4 4 0 Cytoskeletal-regulatory complex EF hand CPL PF08144.6 KOO28945.1 - 1.8e-11 44.1 0.1 2.9e-10 40.1 0.0 3.1 2 2 0 2 2 2 1 CPL (NUC119) domain Patatin PF01734.17 KOO28945.1 - 0.0017 18.2 1.5 0.0017 18.2 1.1 2.2 2 1 0 2 2 2 1 Patatin-like phospholipase PRA-PH PF01503.12 KOO28945.1 - 0.073 13.3 0.2 0.35 11.1 0.1 2.2 1 0 0 1 1 1 0 Phosphoribosyl-ATP pyrophosphohydrolase Peptidase_C48 PF02902.14 KOO28947.1 - 3.3e-39 134.7 0.1 6.3e-38 130.5 0.0 2.6 3 0 0 3 3 3 1 Ulp1 protease family, C-terminal catalytic domain SspK PF08176.7 KOO28947.1 - 0.031 14.2 0.1 0.069 13.1 0.1 1.5 1 0 0 1 1 1 0 Small acid-soluble spore protein K family U-box PF04564.10 KOO28948.1 - 4.8e-13 48.8 0.0 1.3e-12 47.4 0.0 1.8 2 0 0 2 2 2 1 U-box domain G8 PF10162.4 KOO28949.1 - 0.038 13.7 0.0 0.061 13.1 0.0 1.3 1 0 0 1 1 1 0 G8 domain Spc7 PF08317.6 KOO28949.1 - 0.077 11.6 3.9 0.13 10.8 2.7 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein AAA_23 PF13476.1 KOO28949.1 - 0.81 9.9 7.6 0.034 14.4 1.3 1.6 2 0 0 2 2 2 0 AAA domain DUF607 PF04678.8 KOO28949.1 - 2.3 8.1 4.2 1.9 8.3 1.3 2.1 1 1 1 2 2 2 0 Protein of unknown function, DUF607 DUF4604 PF15377.1 KOO28949.1 - 2.5 8.2 12.4 0.28 11.3 5.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4604) Ribosomal_L23 PF00276.15 KOO28950.1 - 4e-18 65.1 2.1 4e-18 65.1 1.5 2.0 2 1 0 2 2 2 1 Ribosomal protein L23 Ribosomal_L23eN PF03939.8 KOO28950.1 - 3.4e-12 46.1 13.8 8.1e-12 44.9 9.6 1.7 1 0 0 1 1 1 1 Ribosomal protein L23, N-terminal domain PAN_4 PF14295.1 KOO28951.1 - 1.3e-06 28.0 8.2 8.5e-06 25.3 5.7 2.5 1 1 0 1 1 1 1 PAN domain Aa_trans PF01490.13 KOO28954.1 - 7.7e-44 149.7 13.2 1e-43 149.4 9.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 KOO28954.1 - 1.3e-05 24.2 9.9 1.3e-05 24.2 6.9 1.5 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family DUF2294 PF10057.4 KOO28955.1 - 0.056 13.0 0.8 0.096 12.3 0.5 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2294) Hydrolase_6 PF13344.1 KOO28956.1 - 9e-16 57.6 0.0 2.2e-15 56.3 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 KOO28956.1 - 5e-14 52.9 0.0 1.1e-06 29.0 0.0 2.5 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOO28956.1 - 1.1e-13 50.6 0.0 2e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 KOO28956.1 - 5e-05 23.8 0.1 0.15 12.4 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase WD40 PF00400.27 KOO28957.1 - 2.6e-23 80.9 0.2 0.0004 20.1 0.0 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat PCP_red PF08369.5 KOO28957.1 - 0.038 13.8 0.2 0.089 12.6 0.2 1.7 1 0 0 1 1 1 0 Proto-chlorophyllide reductase 57 kD subunit DUF458 PF04308.7 KOO28958.1 - 3.9e-14 52.5 0.4 1.7e-12 47.2 0.1 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF458) ATPgrasp_ST PF14397.1 KOO28959.1 - 9e-06 24.9 0.0 1.5e-05 24.2 0.0 1.3 1 1 0 1 1 1 1 Sugar-transfer associated ATP-grasp PCI PF01399.22 KOO28960.1 - 2.7e-18 66.1 0.1 9.8e-18 64.4 0.1 2.0 1 0 0 1 1 1 1 PCI domain PCI_Csn8 PF10075.4 KOO28960.1 - 1.5e-10 41.0 3.0 2.3e-05 24.1 0.0 3.1 2 1 1 3 3 3 2 COP9 signalosome, subunit CSN8 TPR_7 PF13176.1 KOO28960.1 - 2.3e-06 26.9 4.4 0.23 11.3 0.0 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28960.1 - 0.015 15.8 0.1 4.1 8.3 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.1 KOO28960.1 - 0.03 13.9 1.8 2.2 8.0 0.1 3.6 3 2 0 3 3 3 0 TPR repeat TPR_12 PF13424.1 KOO28960.1 - 0.032 14.1 10.2 0.042 13.7 0.0 4.3 4 1 1 5 5 5 0 Tetratricopeptide repeat zf-ZPR1 PF03367.8 KOO28960.1 - 0.044 12.9 0.6 0.18 10.9 0.1 2.2 2 1 0 2 2 2 0 ZPR1 zinc-finger domain FeoC PF09012.5 KOO28960.1 - 0.067 12.9 0.0 0.24 11.1 0.0 2.0 1 1 0 1 1 1 0 FeoC like transcriptional regulator AAA_assoc PF14363.1 KOO28960.1 - 0.069 13.2 0.4 16 5.6 0.0 2.8 3 0 0 3 3 3 0 Domain associated at C-terminal with AAA TPR_10 PF13374.1 KOO28960.1 - 0.092 12.7 0.4 31 4.6 0.0 4.2 6 0 0 6 6 6 0 Tetratricopeptide repeat Glyco_hyd_65N_2 PF14498.1 KOO28960.1 - 0.19 11.3 1.2 0.89 9.1 0.2 2.3 3 0 0 3 3 3 0 Glycosyl hydrolase family 65, N-terminal domain TPR_6 PF13174.1 KOO28960.1 - 0.41 11.2 2.1 33 5.2 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat ABC_membrane PF00664.18 KOO28961.1 - 1.9e-06 27.5 0.1 1.9e-06 27.5 0.1 2.4 3 0 0 3 3 3 1 ABC transporter transmembrane region Ribosomal_L3 PF00297.17 KOO28962.1 - 1e-109 365.9 10.2 1.3e-109 365.6 7.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 FadA PF09403.5 KOO28962.1 - 0.052 13.5 1.8 0.098 12.6 1.2 1.3 1 0 0 1 1 1 0 Adhesion protein FadA EF-hand_7 PF13499.1 KOO28963.1 - 2.2e-24 85.3 0.1 2.9e-10 40.1 0.1 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO28963.1 - 5.4e-23 78.7 0.0 8e-05 22.2 0.0 5.5 5 0 0 5 5 5 5 EF-hand domain EF-hand_1 PF00036.27 KOO28963.1 - 2.7e-21 73.1 0.0 0.00019 20.4 0.1 5.3 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.1 KOO28963.1 - 3.7e-14 52.0 1.0 1.9e-05 24.1 0.5 3.8 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO28963.1 - 4.3e-12 44.7 0.1 0.06 12.7 0.1 4.4 4 0 0 4 4 4 4 EF hand MRP_L53 PF10780.4 KOO28963.1 - 0.087 12.8 0.0 0.25 11.3 0.0 1.7 1 0 0 1 1 1 0 39S ribosomal protein L53/MRP-L53 Arm PF00514.18 KOO28965.1 - 5.3e-33 111.7 26.5 6.2e-07 29.0 0.4 6.7 6 0 0 6 6 6 6 Armadillo/beta-catenin-like repeat U-box PF04564.10 KOO28965.1 - 1.5e-10 40.8 0.0 2.9e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO28965.1 - 5.8e-06 25.7 0.0 1.4e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 KOO28965.1 - 0.012 15.3 0.0 0.043 13.5 0.0 2.0 1 0 0 1 1 1 0 RING-type zinc-finger CoA_binding_2 PF13380.1 KOO28965.1 - 0.44 10.7 12.7 7.8 6.7 0.1 4.6 1 1 4 5 5 5 0 CoA binding domain MORN PF02493.15 KOO28966.1 - 7.6e-61 198.3 111.9 1.1e-07 31.1 1.0 16.5 16 0 0 16 16 16 13 MORN repeat Calreticulin PF00262.13 KOO28966.1 - 0.48 9.0 4.2 7 5.1 0.1 2.5 3 0 0 3 3 3 0 Calreticulin family NinG PF05766.7 KOO28966.1 - 0.7 9.6 5.6 22 4.7 0.1 3.1 3 0 0 3 3 3 0 Bacteriophage Lambda NinG protein Tape_meas_lam_C PF09718.5 KOO28966.1 - 2.5 8.0 6.5 75 3.3 0.0 5.0 5 0 0 5 5 5 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) Bestrophin PF01062.16 KOO28967.1 - 4.6e-36 124.2 0.1 6.7e-36 123.7 0.1 1.2 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel DUF21 PF01595.15 KOO28967.1 - 3.7e-25 88.2 0.3 9e-25 87.0 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function DUF21 DUF3110 PF11360.3 KOO28968.1 - 2.3e-09 36.9 0.0 3.6e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3110) SelR PF01641.13 KOO28969.1 - 1.2e-08 34.6 0.2 0.0013 18.4 0.0 2.1 1 1 1 2 2 2 2 SelR domain IFRD_C PF04836.7 KOO28969.1 - 0.048 13.8 0.3 4.8 7.4 0.0 2.2 1 1 1 2 2 2 0 Interferon-related protein conserved region Glyco_transf_8 PF01501.15 KOO28971.1 - 1.2e-35 123.0 0.0 1.8e-35 122.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 WW PF00397.21 KOO28973.1 - 4.1e-11 42.5 0.2 0.0029 17.4 0.2 3.8 3 1 0 3 3 3 3 WW domain EF-hand_5 PF13202.1 KOO28973.1 - 1.9e-08 33.2 4.4 1.9e-05 23.7 0.1 3.3 4 0 0 4 4 4 2 EF hand EF-hand_1 PF00036.27 KOO28973.1 - 1.4e-07 30.3 2.6 0.0071 15.5 0.0 3.3 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.1 KOO28973.1 - 6.7e-06 25.5 7.3 0.0061 16.3 0.1 4.2 4 0 0 4 4 4 2 EF-hand domain IQ PF00612.22 KOO28973.1 - 0.00014 21.2 2.8 0.13 12.0 0.1 2.4 2 0 0 2 2 2 2 IQ calmodulin-binding motif EF-hand_7 PF13499.1 KOO28973.1 - 0.00084 19.4 4.3 0.0039 17.3 0.5 3.2 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO28973.1 - 0.058 13.0 6.9 1.1 8.9 0.1 3.4 4 0 0 4 4 4 0 EF-hand domain pair FAST_1 PF06743.10 KOO28974.1 - 2.7e-08 33.3 1.2 0.44 10.2 0.0 4.4 2 1 3 5 5 5 3 FAST kinase-like protein, subdomain 1 DUF3367 PF11847.3 KOO28975.1 - 0.034 12.0 1.0 0.054 11.4 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3367) CENP-F_leu_zip PF10473.4 KOO28975.1 - 0.048 13.5 4.4 0.12 12.2 0.6 2.7 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AIP3 PF03915.8 KOO28975.1 - 0.05 12.5 0.2 0.075 11.9 0.1 1.2 1 0 0 1 1 1 0 Actin interacting protein 3 Mei5 PF10376.4 KOO28975.1 - 0.072 12.6 0.9 0.14 11.6 0.4 1.6 2 0 0 2 2 2 0 Double-strand recombination repair protein IncA PF04156.9 KOO28975.1 - 0.19 11.3 2.3 0.98 8.9 0.9 2.2 2 0 0 2 2 2 0 IncA protein DUF3761 PF12587.3 KOO28976.1 - 0.079 13.0 2.6 0.13 12.4 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3761) Atg14 PF10186.4 KOO28976.1 - 0.14 11.0 0.0 0.16 10.8 0.0 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 CLASP_N PF12348.3 KOO28977.1 - 3.3e-08 33.1 0.0 2e-07 30.6 0.0 2.2 2 0 0 2 2 2 1 CLASP N terminal HEAT PF02985.17 KOO28977.1 - 0.13 12.4 1.2 19 5.6 0.0 3.4 2 0 0 2 2 2 0 HEAT repeat Pkinase PF00069.20 KOO28978.1 - 1.8e-45 155.1 0.0 3.7e-45 154.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO28978.1 - 1.6e-24 86.3 0.0 3.1e-24 85.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO28978.1 - 0.00016 21.4 0.0 0.44 10.2 0.0 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family IQ PF00612.22 KOO28978.1 - 0.00078 18.8 0.7 0.0022 17.4 0.5 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif Neur_chan_memb PF02932.11 KOO28979.1 - 0.00013 21.9 3.0 0.00025 21.0 2.1 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF179 PF02622.10 KOO28980.1 - 3.2e-18 65.8 0.2 7.4e-18 64.6 0.1 1.6 1 1 0 1 1 1 1 Uncharacterized ACR, COG1678 Sugar_tr PF00083.19 KOO28981.1 - 1.2e-77 261.4 16.1 2.3e-77 260.4 11.2 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOO28981.1 - 1.2e-14 53.8 62.5 7.5e-13 47.9 27.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KOO28981.1 - 7.8e-06 24.5 15.6 0.0081 14.6 0.0 3.2 2 1 1 3 3 3 2 MFS/sugar transport protein Chloroa_b-bind PF00504.16 KOO28982.1 - 5.9e-27 94.8 0.2 1.6e-13 51.2 0.1 2.3 1 1 1 2 2 2 2 Chlorophyll A-B binding protein Dynein_heavy PF03028.10 KOO28983.1 - 5.7e-124 414.7 0.0 2.1e-123 412.8 0.0 2.0 2 0 0 2 2 1 1 Dynein heavy chain and region D6 of dynein motor AAA_9 PF12781.2 KOO28983.1 - 7.6e-39 132.8 0.0 1.7e-38 131.7 0.0 1.6 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_5 PF07728.9 KOO28983.1 - 1.1e-33 115.8 0.0 8.5e-24 83.8 0.0 4.6 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_8 PF12780.2 KOO28983.1 - 7.4e-32 110.3 0.0 1.6e-31 109.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 MT PF12777.2 KOO28983.1 - 2e-27 95.8 7.0 3.1e-27 95.2 4.8 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 KOO28983.1 - 3.9e-20 72.0 0.2 1.7e-19 70.0 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_6 PF12774.2 KOO28983.1 - 2e-10 40.5 0.0 5.2e-10 39.2 0.0 1.7 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_16 PF13191.1 KOO28983.1 - 6.1e-09 36.1 2.9 0.16 11.9 0.0 4.9 4 0 0 4 4 3 3 AAA ATPase domain AAA_22 PF13401.1 KOO28983.1 - 5.3e-05 23.3 1.4 0.93 9.6 0.0 4.2 4 0 0 4 4 4 2 AAA domain DUF258 PF03193.11 KOO28983.1 - 6.7e-05 22.1 0.1 0.041 13.0 0.0 3.3 3 0 0 3 3 3 1 Protein of unknown function, DUF258 IstB_IS21 PF01695.12 KOO28983.1 - 6.9e-05 22.3 0.1 0.12 11.7 0.0 3.3 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA PF00004.24 KOO28983.1 - 0.00015 22.0 0.2 1.6 8.8 0.0 3.4 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.22 KOO28983.1 - 0.00029 21.1 4.1 0.055 13.7 0.0 4.1 4 1 0 4 4 4 1 ABC transporter AAA_17 PF13207.1 KOO28983.1 - 0.00036 21.3 0.3 0.015 16.0 0.0 3.7 4 0 0 4 4 3 1 AAA domain Guanylate_kin PF00625.16 KOO28983.1 - 0.00042 19.8 0.2 0.16 11.3 0.0 3.5 3 0 0 3 3 3 1 Guanylate kinase Cast PF10174.4 KOO28983.1 - 0.00057 18.0 1.0 0.00057 18.0 0.7 2.6 3 0 0 3 3 3 1 RIM-binding protein of the cytomatrix active zone AAA_23 PF13476.1 KOO28983.1 - 0.001 19.4 3.3 0.63 10.3 0.0 3.4 3 0 0 3 3 3 1 AAA domain Arch_ATPase PF01637.13 KOO28983.1 - 0.0011 18.6 0.0 1.5 8.4 0.0 2.7 2 0 0 2 2 2 2 Archaeal ATPase NACHT PF05729.7 KOO28983.1 - 0.0013 18.3 0.1 2.1 8.0 0.0 2.9 2 0 0 2 2 2 2 NACHT domain AAA_28 PF13521.1 KOO28983.1 - 0.0022 17.9 0.0 0.47 10.3 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 KOO28983.1 - 0.0031 17.4 0.1 2.1 8.2 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 KOO28983.1 - 0.0063 16.4 0.0 5.5 6.9 0.0 3.1 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.17 KOO28983.1 - 0.0085 16.2 0.0 0.19 11.9 0.0 2.5 2 0 0 2 2 2 1 RNA helicase AAA_29 PF13555.1 KOO28983.1 - 0.0088 15.5 0.0 0.46 10.0 0.0 3.0 3 0 0 3 3 3 1 P-loop containing region of AAA domain MobB PF03205.9 KOO28983.1 - 0.019 14.6 0.4 5 6.8 0.0 2.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Mg_chelatase PF01078.16 KOO28983.1 - 0.021 13.9 0.1 8.1 5.5 0.0 2.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Rad17 PF03215.10 KOO28983.1 - 0.027 13.1 0.0 0.3 9.7 0.0 2.2 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein AAA_18 PF13238.1 KOO28983.1 - 0.1 12.9 0.0 0.71 10.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF1664 PF07889.7 KOO28983.1 - 1.2 8.9 9.0 0.79 9.5 1.2 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) L31 PF09784.4 KOO28983.1 - 4.4 7.4 5.0 2.2 8.3 1.0 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L31 V_ATPase_I PF01496.14 KOO28983.1 - 7 4.3 7.8 2.7 5.7 2.7 1.9 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family APG6 PF04111.7 KOO28983.1 - 9.6 5.1 13.4 7.7 5.4 4.6 2.5 2 0 0 2 2 2 0 Autophagy protein Apg6 ANF_receptor PF01094.23 KOO28985.1 - 4.9e-07 28.8 0.0 1e-06 27.8 0.0 1.4 1 1 0 1 1 1 1 Receptor family ligand binding region NT-C2 PF10358.4 KOO28986.1 - 0.082 12.4 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 N-terminal C2 in EEIG1 and EHBP1 proteins MFS_1 PF07690.11 KOO28987.1 - 5.3e-06 25.3 7.9 1.9e-05 23.5 5.6 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily MARVEL PF01284.18 KOO28987.1 - 0.017 14.9 6.2 0.96 9.2 0.7 2.8 3 0 0 3 3 3 0 Membrane-associating domain Hydrolase_like PF13242.1 KOO28989.1 - 6.4e-11 41.8 0.0 1.7e-10 40.4 0.0 1.8 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.1 KOO28989.1 - 5.4e-10 39.0 0.0 1.5e-09 37.6 0.0 1.8 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase EF-hand_1 PF00036.27 KOO28989.1 - 0.0021 17.2 0.3 0.12 11.7 0.1 2.5 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO28989.1 - 0.007 16.1 0.1 0.14 12.1 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.1 KOO28989.1 - 0.021 14.9 0.0 0.066 13.3 0.0 1.8 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.1 KOO28989.1 - 0.05 12.9 0.3 0.13 11.6 0.2 1.6 1 0 0 1 1 1 0 EF hand Hydrolase PF00702.21 KOO28989.1 - 0.055 13.8 0.1 3.2 8.1 0.1 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.5 KOO28989.1 - 0.13 11.5 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase LRR_4 PF12799.2 KOO28990.1 - 0.064 12.9 0.0 6.7 6.4 0.0 2.5 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) Filament PF00038.16 KOO28990.1 - 0.12 11.8 35.4 0.14 11.5 0.4 3.3 3 0 0 3 3 3 0 Intermediate filament protein Prefoldin_2 PF01920.15 KOO28990.1 - 1 9.1 8.1 0.21 11.3 1.3 2.9 1 1 0 2 2 2 0 Prefoldin subunit SHIPPO-rpt PF07004.7 KOO28992.1 - 1.3e-05 25.8 27.4 0.12 13.3 0.1 7.5 7 0 0 7 7 7 4 Sperm-tail PG-rich repeat FHA PF00498.21 KOO28993.1 - 0.025 14.6 0.0 0.039 14.0 0.0 1.3 1 0 0 1 1 1 0 FHA domain Pro-rich PF15240.1 KOO28993.1 - 0.35 10.9 12.2 0.68 10.0 8.4 1.6 1 1 0 1 1 1 0 Proline-rich UvrD-helicase PF00580.16 KOO28994.1 - 9.6e-47 159.7 0.1 1.3e-26 93.6 0.0 2.4 1 1 1 2 2 2 2 UvrD/REP helicase N-terminal domain UvrD_C PF13361.1 KOO28994.1 - 1.3e-34 120.2 0.0 4.4e-19 69.1 0.0 2.2 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_19 PF13245.1 KOO28994.1 - 3.1e-14 52.4 0.6 3.1e-14 52.4 0.4 4.2 4 0 0 4 4 4 1 Part of AAA domain UvrD_C_2 PF13538.1 KOO28994.1 - 3e-09 36.9 0.0 8.5e-09 35.4 0.0 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_11 PF13086.1 KOO28994.1 - 6.3e-09 35.7 0.6 8.9e-05 22.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.13 KOO28994.1 - 2.7e-06 27.0 1.5 0.19 11.1 0.0 3.6 3 1 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.1 KOO28994.1 - 0.054 13.6 0.0 0.22 11.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_12 PF13087.1 KOO28994.1 - 0.16 11.3 0.0 0.6 9.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain PfkB PF00294.19 KOO28995.1 - 6.3e-47 160.1 2.2 1e-46 159.4 1.5 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase AP_endonuc_2 PF01261.19 KOO28995.1 - 2.3e-18 66.2 0.0 1.1e-17 63.9 0.0 2.2 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel STAS PF01740.16 KOO28995.1 - 3.5e-10 39.3 0.1 1.1e-09 37.6 0.0 1.9 1 0 0 1 1 1 1 STAS domain Phos_pyr_kin PF08543.7 KOO28995.1 - 1.5e-07 30.8 0.0 2.6e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase cNMP_binding PF00027.24 KOO28995.1 - 0.017 14.9 0.0 0.049 13.4 0.0 1.8 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain CLN3 PF02487.12 KOO28996.1 - 1.1e-28 100.1 9.1 2.6e-15 56.1 0.0 2.7 1 1 2 3 3 3 2 CLN3 protein EF-hand_1 PF00036.27 KOO28997.1 - 2.6e-20 70.1 0.1 2.7e-05 23.1 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO28997.1 - 1.9e-16 58.3 0.4 0.00082 19.0 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO28997.1 - 1.5e-14 53.8 1.8 5.8e-05 23.1 0.0 4.3 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO28997.1 - 5.5e-10 38.1 0.0 0.14 11.5 0.0 4.6 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.1 KOO28997.1 - 1.9e-09 36.9 0.9 0.0019 17.7 0.0 4.3 3 1 1 4 4 4 3 EF-hand domain pair TPR_12 PF13424.1 KOO28997.1 - 8.1e-05 22.4 6.1 0.0041 17.0 0.3 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO28997.1 - 0.0045 16.6 3.5 0.058 13.0 0.1 3.1 2 1 2 4 4 4 1 TPR repeat Hen1_L PF12623.2 KOO28997.1 - 0.0072 15.1 0.5 15 4.2 0.0 3.4 2 2 1 3 3 3 0 RNA repair, ligase-Pnkp-associating, region of Hen1 EF-hand_4 PF12763.2 KOO28997.1 - 0.01 15.5 0.5 8 6.2 0.1 2.7 2 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand DUF960 PF06124.6 KOO28997.1 - 0.02 15.1 0.1 5 7.4 0.0 2.4 2 0 0 2 2 2 0 Staphylococcal protein of unknown function (DUF960) TPR_10 PF13374.1 KOO28997.1 - 0.12 12.3 0.1 0.12 12.3 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO28997.1 - 0.63 10.8 11.2 17 6.3 0.3 5.0 4 0 0 4 4 4 0 Tetratricopeptide repeat APH PF01636.18 KOO28998.1 - 3.9e-39 134.7 1.8 8.3e-39 133.7 1.3 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Acyl-CoA_dh_1 PF00441.19 KOO28998.1 - 3e-31 108.5 6.7 3e-31 108.5 4.6 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 KOO28998.1 - 2.8e-15 55.5 0.0 5.1e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.11 KOO28998.1 - 5.9e-13 49.3 0.0 1.7e-12 47.8 0.0 1.9 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.6 KOO28998.1 - 8.5e-10 38.9 6.2 8.5e-10 38.9 4.3 2.0 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, C-terminal domain EcKinase PF02958.15 KOO28998.1 - 8.1e-05 21.9 0.0 0.00014 21.1 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.6 KOO28998.1 - 0.023 13.3 0.0 0.033 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Sulfatase PF00884.18 KOO28999.1 - 1e-22 80.7 0.0 1.4e-22 80.2 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.1 KOO28999.1 - 1.1e-17 64.5 0.0 1.9e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.17 KOO28999.1 - 0.0016 17.8 0.0 0.0024 17.2 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Rick_17kDa_Anti PF05433.10 KOO29000.1 - 0.014 15.0 14.3 0.16 11.6 1.4 2.7 2 0 0 2 2 2 0 Glycine zipper 2TM domain Gly-zipper_YMGG PF13441.1 KOO29000.1 - 0.018 14.5 23.7 0.037 13.5 4.8 2.8 3 0 0 3 3 3 0 YMGG-like Gly-zipper T2SM PF04612.7 KOO29000.1 - 0.07 12.9 1.5 0.093 12.5 1.0 1.3 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M Bacteriocin_IIc PF10439.4 KOO29000.1 - 0.072 13.2 11.0 0.17 12.0 2.0 2.3 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide DUF3987 PF13148.1 KOO29000.1 - 0.079 11.5 3.9 0.098 11.2 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Gly-zipper_Omp PF13488.1 KOO29000.1 - 0.14 11.7 21.7 0.22 11.1 1.4 2.6 3 0 0 3 3 3 0 Glycine zipper DUF1269 PF06897.7 KOO29000.1 - 0.77 9.8 6.1 3.6 7.6 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1269) UvrD-helicase PF00580.16 KOO29001.1 - 3.5e-49 167.8 0.0 7.9e-49 166.6 0.0 1.6 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.1 KOO29001.1 - 6.4e-49 167.2 0.0 2.6e-27 96.2 0.0 2.0 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.1 KOO29001.1 - 2.5e-10 40.4 0.0 6.4e-10 39.0 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.1 KOO29001.1 - 2e-09 37.0 0.9 1.3e-08 34.4 0.1 2.9 2 0 0 2 2 2 1 Part of AAA domain AAA_12 PF13087.1 KOO29001.1 - 1.3e-05 24.6 0.0 0.00051 19.4 0.0 2.6 2 1 1 3 3 3 1 AAA domain Viral_helicase1 PF01443.13 KOO29001.1 - 0.0004 19.9 0.1 0.0084 15.6 0.0 2.6 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.1 KOO29001.1 - 0.088 12.9 1.0 14 5.7 0.0 3.2 3 1 0 3 3 3 0 AAA domain PhoH PF02562.11 KOO29001.1 - 0.15 11.2 0.1 3.3 6.8 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein EF-hand_6 PF13405.1 KOO29002.1 - 0.014 15.2 0.0 0.046 13.6 0.0 2.0 1 1 0 1 1 1 0 EF-hand domain EF-hand_5 PF13202.1 KOO29002.1 - 0.02 14.2 0.0 0.049 12.9 0.0 1.6 1 0 0 1 1 1 0 EF hand EF-hand_1 PF00036.27 KOO29002.1 - 0.05 12.9 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.1 KOO29002.1 - 0.13 12.3 0.1 0.43 10.7 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain pair FtsJ PF01728.14 KOO29003.1 - 2.3e-64 216.7 0.0 2.6e-64 216.5 0.0 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_18 PF12847.2 KOO29003.1 - 0.0011 19.4 0.1 0.0054 17.2 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain DUF563 PF04577.9 KOO29004.1 - 5.1e-05 23.2 0.2 8e-05 22.6 0.2 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF563) VCBS PF13517.1 KOO29005.1 - 2.1e-183 594.8 223.5 7.9e-14 51.7 4.1 18.4 1 1 18 19 19 19 19 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO29005.1 - 3.2e-89 290.8 203.7 7.4e-06 25.5 1.3 19.4 19 0 0 19 19 19 19 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO29005.1 - 1.2e-33 116.0 77.1 0.077 12.4 0.0 18.9 2 2 17 19 19 19 16 Insecticide toxin TcdB middle/N-terminal region DUF4384 PF14326.1 KOO29005.1 - 3.2e-14 52.5 0.1 6.7 6.6 0.0 14.1 5 5 12 17 17 17 1 Domain of unknown function (DUF4384) Arrestin_N PF00339.24 KOO29005.1 - 1.5e-08 34.5 0.0 21 4.9 0.0 10.6 15 0 0 15 15 15 0 Arrestin (or S-antigen), N-terminal domain Phage_AlpA PF05930.7 KOO29005.1 - 0.00056 19.5 0.0 1.3e+02 2.4 0.0 8.6 13 0 0 13 13 13 0 Prophage CP4-57 regulatory protein (AlpA) YuzL PF14115.1 KOO29005.1 - 0.0037 17.4 24.3 23 5.3 0.0 12.5 15 0 0 15 15 15 0 YuzL-like protein DUF3459 PF11941.3 KOO29005.1 - 0.026 14.6 10.9 1.2e+02 2.8 0.0 9.2 3 2 6 10 10 10 0 Domain of unknown function (DUF3459) LCAT PF02450.10 KOO29005.1 - 1.5 7.7 2.7 1.9e+02 0.8 0.0 5.7 12 0 0 12 12 12 0 Lecithin:cholesterol acyltransferase Glucodextran_B PF09136.5 KOO29005.1 - 8.7 6.5 78.1 1.1 9.4 0.2 15.6 4 4 13 17 17 17 0 Glucodextranase, domain B Pkinase PF00069.20 KOO29006.1 - 2.8e-57 193.8 0.0 3.4e-57 193.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29006.1 - 5.8e-42 143.5 0.0 7.9e-42 143.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO29006.1 - 1.3e-07 30.9 0.0 0.0026 16.7 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 KOO29006.1 - 0.0028 17.4 0.1 0.5 10.0 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family ABC1 PF03109.11 KOO29007.1 - 9.9e-30 102.9 0.0 2.6e-29 101.6 0.0 1.7 2 0 0 2 2 2 1 ABC1 family APH PF01636.18 KOO29007.1 - 0.00041 20.1 0.1 0.00041 20.1 0.1 3.3 3 1 1 4 4 4 1 Phosphotransferase enzyme family WaaY PF06176.6 KOO29007.1 - 0.061 12.5 0.0 0.098 11.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Pkinase PF00069.20 KOO29007.1 - 0.086 11.9 0.0 8 5.5 0.0 2.2 2 0 0 2 2 2 0 Protein kinase domain Peptidase_S10 PF00450.17 KOO29009.1 - 4.8e-110 368.5 2.9 7.3e-110 367.9 2.0 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase cNMP_binding PF00027.24 KOO29009.1 - 2.7e-35 120.0 0.0 6.2e-14 51.5 0.0 3.6 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Abhydrolase_6 PF12697.2 KOO29009.1 - 0.0014 18.5 0.0 0.0084 16.0 0.0 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Myosin_head PF00063.16 KOO29010.1 - 3e-177 590.7 0.0 6.6e-177 589.6 0.0 1.5 2 0 0 2 2 2 1 Myosin head (motor domain) PDZ PF00595.19 KOO29010.1 - 1.8e-09 37.6 1.5 0.00023 21.2 0.0 3.8 3 1 0 3 3 3 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO29010.1 - 5.2e-07 29.4 0.2 0.48 10.3 0.0 4.4 4 0 0 4 4 4 2 PDZ domain WW PF00397.21 KOO29010.1 - 8.7e-06 25.4 1.0 1.6e-05 24.6 0.7 1.4 1 0 0 1 1 1 1 WW domain AAA_19 PF13245.1 KOO29010.1 - 0.0027 17.4 0.1 0.01 15.5 0.1 2.1 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 KOO29010.1 - 0.004 17.2 1.8 0.01 15.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KOO29010.1 - 0.032 14.2 0.0 0.032 14.2 0.0 3.6 3 1 0 3 3 3 0 AAA ATPase domain Asp-B-Hydro_N PF05279.6 KOO29010.1 - 2.1 8.1 29.5 5.4 6.7 20.5 1.7 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Metallophos PF00149.23 KOO29011.1 - 1.4e-17 63.7 0.8 2.3e-17 63.0 0.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.1 KOO29011.1 - 3.3e-07 30.2 4.5 0.00028 20.8 0.1 2.9 3 0 0 3 3 3 2 Iron/zinc purple acid phosphatase-like protein C Metallophos_2 PF12850.2 KOO29011.1 - 0.01 15.7 0.0 0.021 14.6 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain TPR_11 PF13414.1 KOO29012.1 - 7e-15 54.4 2.5 3.6e-05 23.3 0.0 4.0 4 0 0 4 4 4 3 TPR repeat TPR_17 PF13431.1 KOO29012.1 - 1.2e-09 37.5 0.0 0.13 12.5 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO29012.1 - 2.5e-08 33.1 0.0 0.0036 16.8 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO29012.1 - 4.3e-08 32.9 8.1 0.0041 17.0 0.0 4.0 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO29012.1 - 6e-08 32.0 6.1 0.024 14.5 0.0 5.8 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO29012.1 - 1.1e-06 28.7 13.3 0.0022 18.4 0.4 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO29012.1 - 6.6e-06 26.6 14.7 0.24 12.1 0.1 4.2 3 1 0 4 4 4 3 Tetratricopeptide repeat Apc3 PF12895.2 KOO29012.1 - 7.4e-05 22.8 0.2 0.094 12.8 0.0 3.1 3 1 1 4 4 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.1 KOO29012.1 - 0.00084 18.4 1.8 0.34 9.9 0.1 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO29012.1 - 0.0011 18.5 4.3 0.59 10.0 0.2 3.7 4 1 0 4 4 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO29012.1 - 0.0046 16.7 3.6 0.7 9.7 0.0 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO29012.1 - 0.01 16.1 4.9 2.3 8.6 0.1 3.5 3 2 2 5 5 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO29012.1 - 0.027 14.9 1.3 13 6.5 0.1 3.8 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_20 PF14561.1 KOO29012.1 - 0.064 13.3 1.5 14 5.9 0.1 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOO29012.1 - 0.078 12.7 0.2 50 4.0 0.0 4.1 4 1 1 5 5 5 0 Tetratricopeptide repeat SLT_L PF14718.1 KOO29012.1 - 1.8 8.4 5.5 22 4.9 0.0 3.3 3 1 1 4 4 4 0 Soluble lytic murein transglycosylase L domain TPR_10 PF13374.1 KOO29012.1 - 3.2 7.8 0.0 3.2 7.8 0.0 4.4 6 0 0 6 6 5 0 Tetratricopeptide repeat Tubulin PF00091.20 KOO29013.1 - 1.5e-08 34.7 0.1 1.5e-08 34.7 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.4 KOO29013.1 - 0.027 14.5 0.0 0.027 14.5 0.0 1.1 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain Aa_trans PF01490.13 KOO29014.1 - 1e-39 136.2 17.8 8e-33 113.5 6.0 2.6 1 1 1 2 2 2 2 Transmembrane amino acid transporter protein NTPase_I-T PF01931.13 KOO29016.1 - 1.7e-22 79.9 0.3 2.4e-11 43.6 0.0 3.1 1 1 1 2 2 2 2 Protein of unknown function DUF84 DUF3429 PF11911.3 KOO29016.1 - 0.23 11.4 16.4 0.43 10.5 7.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3429) Ribosomal_L32e PF01655.13 KOO29017.1 - 2.8e-42 143.2 2.4 3.4e-42 142.9 1.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L32 Exo_endo_phos PF03372.18 KOO29019.1 - 7.3e-06 26.0 0.4 0.00027 20.9 0.0 2.1 1 1 1 2 2 2 2 Endonuclease/Exonuclease/phosphatase family HA PF03457.9 KOO29020.1 - 2.8e-30 104.2 15.6 1.2e-15 57.3 0.2 4.1 4 1 0 4 4 4 3 Helicase associated domain Peptidase_C14 PF00656.17 KOO29020.1 - 3.6e-07 30.1 0.0 6.1e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Caspase domain RuvA_C PF07499.8 KOO29020.1 - 0.034 14.3 0.4 1.3 9.2 0.1 2.9 2 0 0 2 2 2 0 RuvA, C-terminal domain PWI PF01480.12 KOO29021.1 - 1.5e-10 41.0 0.0 2e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 PWI domain Silic_transp PF03842.8 KOO29022.1 - 1 7.3 3.4 1.3 6.9 2.3 1.1 1 0 0 1 1 1 0 Silicon transporter PV-1 PF06637.6 KOO29022.1 - 1.5 7.3 8.5 1.9 6.9 5.9 1.2 1 0 0 1 1 1 0 PV-1 protein (PLVAP) DUF4604 PF15377.1 KOO29022.1 - 7.6 6.7 15.8 20 5.3 11.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4604) CDC45 PF02724.9 KOO29022.1 - 8.4 4.2 8.1 8.8 4.2 5.6 1.0 1 0 0 1 1 1 0 CDC45-like protein EF-hand_1 PF00036.27 KOO29023.1 - 1.7e-27 92.5 4.7 1.7e-06 26.9 0.2 6.2 6 0 0 6 6 6 4 EF hand EF-hand_7 PF13499.1 KOO29023.1 - 9.6e-24 83.3 2.4 4.4e-10 39.5 0.8 3.7 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO29023.1 - 8e-21 73.4 16.8 5.4e-06 25.9 0.7 5.0 3 2 2 5 5 5 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO29023.1 - 3.8e-18 63.6 4.6 0.00051 19.6 0.1 6.4 6 0 0 6 6 6 3 EF-hand domain EF-hand_5 PF13202.1 KOO29023.1 - 3.9e-17 60.7 9.9 0.00015 20.9 0.1 5.4 5 0 0 5 5 5 4 EF hand EF-hand_10 PF14788.1 KOO29023.1 - 0.00017 21.2 0.2 0.83 9.3 0.0 2.9 2 0 0 2 2 2 2 EF hand RIIa PF02197.12 KOO29023.1 - 0.00072 18.9 0.0 0.0017 17.7 0.0 1.6 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit EF-hand_4 PF12763.2 KOO29023.1 - 0.0065 16.1 5.2 2.1 8.1 0.0 4.3 3 2 2 5 5 5 1 Cytoskeletal-regulatory complex EF hand MatE PF01554.13 KOO29024.1 - 4.8e-20 71.7 18.8 4.7e-12 45.8 2.1 3.0 2 2 1 3 3 3 2 MatE Polysacc_synt_C PF14667.1 KOO29024.1 - 5e-08 32.8 3.6 5e-08 32.8 2.5 3.5 3 1 1 4 4 4 1 Polysaccharide biosynthesis C-terminal domain AAA PF00004.24 KOO29026.1 - 1.2e-91 303.7 0.0 5.3e-47 159.3 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO29026.1 - 2.1e-14 53.9 1.9 2e-06 27.9 0.0 3.4 2 2 0 2 2 2 2 AAA ATPase domain RuvB_N PF05496.7 KOO29026.1 - 1.9e-13 49.9 0.0 7.3e-06 25.1 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 KOO29026.1 - 1.6e-11 44.2 0.0 0.00023 21.0 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_22 PF13401.1 KOO29026.1 - 2.1e-11 44.0 0.2 0.004 17.3 0.0 4.1 2 2 1 3 3 3 2 AAA domain AAA_17 PF13207.1 KOO29026.1 - 4.9e-11 43.5 0.0 0.00043 21.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.9 KOO29026.1 - 6.9e-11 42.3 0.0 0.00052 19.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 KOO29026.1 - 5.9e-10 39.0 0.3 0.0012 18.5 0.0 3.5 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 KOO29026.1 - 6.6e-10 38.7 4.6 0.031 13.6 0.0 4.4 2 2 1 4 4 4 3 AAA domain AAA_14 PF13173.1 KOO29026.1 - 1.9e-09 37.5 0.0 0.0018 18.1 0.0 2.3 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 KOO29026.1 - 2.5e-09 36.8 0.0 0.00051 19.5 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein TIP49 PF06068.8 KOO29026.1 - 4.3e-09 35.5 0.1 0.00036 19.3 0.0 2.3 2 1 0 2 2 2 2 TIP49 C-terminus NACHT PF05729.7 KOO29026.1 - 1.1e-08 34.9 0.5 0.0089 15.7 0.0 3.6 3 1 1 4 4 3 2 NACHT domain RNA_helicase PF00910.17 KOO29026.1 - 2.2e-08 34.1 0.0 0.0096 16.0 0.0 2.4 2 0 0 2 2 2 2 RNA helicase AAA_19 PF13245.1 KOO29026.1 - 3.5e-08 33.0 6.7 0.0013 18.4 0.2 3.8 3 2 0 3 3 2 2 Part of AAA domain AAA_3 PF07726.6 KOO29026.1 - 1.5e-07 31.0 0.0 0.0017 17.9 0.0 2.5 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.16 KOO29026.1 - 1.3e-06 27.7 0.4 0.036 13.2 0.1 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 KOO29026.1 - 1.4e-06 27.5 0.0 0.017 14.2 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_28 PF13521.1 KOO29026.1 - 2.2e-06 27.7 0.1 0.091 12.7 0.0 3.3 3 0 0 3 3 3 2 AAA domain ABC_tran PF00005.22 KOO29026.1 - 9.2e-06 25.9 0.0 0.066 13.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_18 PF13238.1 KOO29026.1 - 2.6e-05 24.5 0.0 0.07 13.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain KaiC PF06745.8 KOO29026.1 - 3.3e-05 23.1 0.0 2.1 7.3 0.0 3.2 3 0 0 3 3 3 1 KaiC PhoH PF02562.11 KOO29026.1 - 4.6e-05 22.7 0.0 0.6 9.3 0.0 3.3 4 0 0 4 4 3 2 PhoH-like protein Rad17 PF03215.10 KOO29026.1 - 9.7e-05 21.2 0.0 0.17 10.5 0.0 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein NB-ARC PF00931.17 KOO29026.1 - 0.00017 20.5 0.0 0.061 12.1 0.0 2.2 2 0 0 2 2 2 1 NB-ARC domain Viral_helicase1 PF01443.13 KOO29026.1 - 0.00018 21.1 0.0 0.085 12.3 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase UPF0079 PF02367.12 KOO29026.1 - 0.00056 19.5 0.0 0.21 11.2 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 SKI PF01202.17 KOO29026.1 - 0.00063 19.6 0.1 0.68 9.7 0.0 2.8 3 0 0 3 3 2 1 Shikimate kinase Sigma54_activat PF00158.21 KOO29026.1 - 0.00099 18.6 0.1 0.21 11.0 0.0 3.2 3 1 0 3 3 3 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.1 KOO29026.1 - 0.0024 17.9 0.0 0.21 11.6 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain DUF2075 PF09848.4 KOO29026.1 - 0.0038 16.2 0.0 1.4 7.8 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.1 KOO29026.1 - 0.0039 16.7 0.0 2.2 7.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 KOO29026.1 - 0.0053 16.4 0.0 2.4 7.8 0.0 3.0 2 1 1 3 3 3 1 Archaeal ATPase Cytidylate_kin2 PF13189.1 KOO29026.1 - 0.0091 15.9 0.0 1.6 8.6 0.0 2.2 2 0 0 2 2 2 1 Cytidylate kinase-like family Parvo_NS1 PF01057.12 KOO29026.1 - 0.0091 14.8 0.0 0.5 9.1 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 Zot PF05707.7 KOO29026.1 - 0.013 14.9 0.1 2.2 7.7 0.0 3.4 3 1 0 3 3 2 0 Zonular occludens toxin (Zot) ATP-synt_ab PF00006.20 KOO29026.1 - 0.015 14.8 0.0 2.9 7.3 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain ResIII PF04851.10 KOO29026.1 - 0.015 15.1 0.0 1.5 8.6 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit NTPase_1 PF03266.10 KOO29026.1 - 0.031 13.9 0.2 4.3 7.0 0.0 3.1 2 1 1 3 3 3 0 NTPase AAA_24 PF13479.1 KOO29026.1 - 0.046 13.2 0.2 5.1 6.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain AFG1_ATPase PF03969.11 KOO29026.1 - 0.06 12.1 0.0 0.89 8.2 0.0 2.3 2 0 0 2 2 2 0 AFG1-like ATPase DAP3 PF10236.4 KOO29026.1 - 0.17 10.8 0.2 20 4.0 0.0 2.5 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 cobW PF02492.14 KOO29026.1 - 0.17 11.3 0.4 19 4.6 0.0 2.6 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_10 PF12846.2 KOO29026.1 - 0.21 10.9 0.2 18 4.6 0.0 2.8 2 1 0 3 3 3 0 AAA-like domain DUF815 PF05673.8 KOO29026.1 - 0.24 10.2 0.0 2.1 7.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Torsin PF06309.6 KOO29026.1 - 0.26 11.1 0.0 19 5.1 0.0 2.4 2 0 0 2 2 2 0 Torsin Bac_DnaA PF00308.13 KOO29026.1 - 0.27 10.8 0.0 5.7 6.5 0.0 2.4 2 1 0 2 2 2 0 Bacterial dnaA protein TPR_4 PF07721.9 KOO29027.1 - 0.87 10.2 4.0 0.59 10.7 0.3 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Pkinase PF00069.20 KOO29028.1 - 2.9e-55 187.2 0.0 3.7e-55 186.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29028.1 - 3.3e-21 75.5 0.0 7.7e-21 74.3 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 KOO29028.1 - 0.012 15.3 0.0 0.026 14.2 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.15 KOO29028.1 - 0.026 14.1 0.0 0.067 12.7 0.0 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase Kdo PF06293.9 KOO29028.1 - 0.074 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4088 PF13317.1 KOO29029.1 - 0.044 13.1 2.2 0.062 12.6 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4088) ATP-synt_E PF05680.7 KOO29029.1 - 1.3 8.9 7.4 0.6 10.1 3.6 1.5 2 0 0 2 2 2 0 ATP synthase E chain DUF3708 PF12501.3 KOO29029.1 - 3.6 7.3 8.6 3.7 7.3 5.4 1.5 1 1 0 1 1 1 0 Phosphate ATP-binding cassette transporter TFIIA PF03153.8 KOO29029.1 - 7.2 6.4 7.4 7.6 6.3 5.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nop10p PF04135.7 KOO29030.1 - 4.1 7.2 10.7 0.18 11.5 1.1 2.6 2 0 0 2 2 2 0 Nucleolar RNA-binding protein, Nop10p family DNA_Packaging_2 PF11123.3 KOO29032.1 - 0.014 15.2 0.1 0.022 14.6 0.1 1.3 1 0 0 1 1 1 0 DNA packaging protein Sec2p PF06428.6 KOO29032.1 - 0.16 11.7 5.6 0.12 12.2 1.7 2.0 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p CBFD_NFYB_HMF PF00808.18 KOO29033.1 - 6.1e-08 32.6 0.0 8.4e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-X PF09415.5 KOO29033.1 - 0.032 14.0 0.0 0.042 13.6 0.0 1.2 1 0 0 1 1 1 0 CENP-S associating Centromere protein X Histone PF00125.19 KOO29033.1 - 0.1 12.7 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Baculo_PEP_C PF04513.7 KOO29034.1 - 1.9 8.3 23.2 1.9 8.3 2.2 5.0 5 0 0 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus Glyco_transf_29 PF00777.13 KOO29035.1 - 1.1e-32 113.2 0.0 1.7e-32 112.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) LigB PF02900.13 KOO29036.1 - 0.011 14.7 1.8 0.025 13.5 0.0 2.2 3 0 0 3 3 3 0 Catalytic LigB subunit of aromatic ring-opening dioxygenase EF-hand_7 PF13499.1 KOO29037.1 - 1.7e-35 120.9 15.3 5.4e-09 36.0 1.8 7.7 4 4 3 7 7 7 7 EF-hand domain pair EF-hand_1 PF00036.27 KOO29037.1 - 1.1e-32 108.8 16.0 0.00078 18.5 0.0 9.5 9 0 0 9 9 9 8 EF hand EF-hand_6 PF13405.1 KOO29037.1 - 1.5e-29 99.1 19.3 0.0029 17.3 0.1 10.5 10 0 0 10 10 10 8 EF-hand domain EF-hand_5 PF13202.1 KOO29037.1 - 1.2e-27 93.9 22.3 0.00011 21.4 0.1 9.4 9 0 0 9 9 9 7 EF hand EF-hand_8 PF13833.1 KOO29037.1 - 5.8e-24 83.4 12.9 2.4e-05 23.8 1.7 8.7 7 2 2 9 9 9 7 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO29037.1 - 9.4e-06 25.6 0.8 1.7 8.7 0.0 5.3 5 1 0 5 5 5 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO29037.1 - 0.02 14.6 3.5 1.1 9.0 0.0 4.1 5 1 1 6 6 6 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO29037.1 - 0.051 13.2 1.4 2.1 8.0 0.0 3.9 5 1 0 5 5 5 0 EF hand Pentapeptide_2 PF01469.13 KOO29037.1 - 0.49 10.0 3.1 0.83 9.3 2.2 1.3 1 0 0 1 1 1 0 Pentapeptide repeats (8 copies) Gb3_synth PF04572.7 KOO29038.1 - 2.6e-16 59.5 0.0 2.1e-07 30.7 0.0 2.2 2 0 0 2 2 2 2 Alpha 1,4-glycosyltransferase conserved region Gly_transf_sug PF04488.10 KOO29038.1 - 2e-15 57.0 0.0 3.1e-15 56.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 KOO29038.1 - 0.005 15.3 0.2 0.0068 14.9 0.1 1.1 1 0 0 1 1 1 1 TcdA/TcdB catalytic glycosyltransferase domain Caps_synth PF05704.7 KOO29038.1 - 0.012 14.7 0.0 0.017 14.2 0.0 1.1 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein DUF810 PF05664.6 KOO29040.1 - 2.9e-05 22.6 0.0 0.0039 15.5 0.0 2.2 1 1 0 2 2 2 2 Protein of unknown function (DUF810) EF-hand_1 PF00036.27 KOO29041.1 - 1.2e-16 58.6 3.8 1.4e-07 30.2 0.3 2.9 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO29041.1 - 2e-15 55.1 3.1 4e-07 29.3 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO29041.1 - 4.8e-13 49.0 1.4 2e-11 43.8 1.0 2.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO29041.1 - 5.4e-13 47.6 3.4 2e-06 26.8 0.2 2.8 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO29041.1 - 7.7e-12 44.6 6.8 1.5e-07 30.9 0.7 2.8 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_10 PF14788.1 KOO29041.1 - 0.022 14.4 2.6 0.24 11.1 0.1 2.5 2 0 0 2 2 2 0 EF hand MS_channel PF00924.13 KOO29043.1 - 3.8e-32 111.3 0.0 6.2e-32 110.5 0.0 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel Malate_synthase PF01274.17 KOO29044.1 - 4.7e-103 344.9 0.0 4.2e-60 203.2 0.0 2.0 1 1 1 2 2 2 2 Malate synthase Sulfotransfer_2 PF03567.9 KOO29045.1 - 0.037 13.7 0.1 0.093 12.3 0.0 1.6 2 0 0 2 2 2 0 Sulfotransferase family Arm PF00514.18 KOO29046.1 - 3.2e-31 106.0 9.4 7.1e-08 31.9 0.2 5.3 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat U-box PF04564.10 KOO29046.1 - 4.9e-13 48.8 0.0 1.1e-12 47.7 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO29046.1 - 1.6e-05 24.2 0.0 3.6e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Arm_2 PF04826.8 KOO29046.1 - 0.00043 19.4 0.0 0.19 10.8 0.0 2.5 1 1 2 3 3 3 3 Armadillo-like Atx10homo_assoc PF09759.4 KOO29046.1 - 0.029 14.1 0.0 4 7.2 0.0 3.0 2 1 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain Rtf2 PF04641.7 KOO29046.1 - 1.4 8.0 4.5 5.6 6.0 3.1 1.8 1 1 0 1 1 1 0 Rtf2 RING-finger Bap31 PF05529.7 KOO29046.1 - 6.6 6.1 4.7 12 5.2 3.3 1.4 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like DUF4200 PF13863.1 KOO29047.1 - 0.0086 16.0 18.8 0.052 13.5 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4200) Macoilin PF09726.4 KOO29047.1 - 0.13 10.5 16.8 0.17 10.1 11.6 1.2 1 0 0 1 1 1 0 Transmembrane protein AAA_13 PF13166.1 KOO29047.1 - 0.16 10.4 5.0 0.2 10.0 3.5 1.2 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.3 KOO29047.1 - 0.27 8.4 22.8 0.37 8.0 15.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) IFT57 PF10498.4 KOO29047.1 - 0.35 9.5 8.8 0.3 9.7 3.0 2.0 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Spc7 PF08317.6 KOO29047.1 - 1.1 7.8 15.2 1.8 7.1 10.2 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF4320 PF14208.1 KOO29047.1 - 2.2 8.2 3.7 1.9 8.4 0.4 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4320) DUF342 PF03961.8 KOO29047.1 - 2.5 6.4 4.4 3.8 5.8 3.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Prefoldin_2 PF01920.15 KOO29047.1 - 3 7.6 11.9 16 5.3 3.8 3.1 3 0 0 3 3 3 0 Prefoldin subunit TMF_DNA_bd PF12329.3 KOO29047.1 - 5.1 6.9 22.6 3.6 7.4 5.7 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Syntaxin-6_N PF09177.6 KOO29047.1 - 6 7.3 10.7 2e+02 2.4 6.8 3.1 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Inositol_P PF00459.20 KOO29048.1 - 5.5e-09 35.7 0.3 8.4e-09 35.1 0.2 1.2 1 0 0 1 1 1 1 Inositol monophosphatase family DUF1499 PF07386.6 KOO29049.1 - 2.4e-15 56.7 1.6 2.2e-14 53.6 1.1 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1499) MdcG PF10620.4 KOO29049.1 - 0.21 11.0 1.9 0.47 9.9 1.3 1.5 1 1 0 1 1 1 0 Phosphoribosyl-dephospho-CoA transferase MdcG Methyltransf_21 PF05050.7 KOO29050.1 - 0.00021 21.2 0.1 0.00034 20.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain TSC22 PF01166.13 KOO29052.1 - 0.06 13.3 0.3 0.06 13.3 0.2 3.6 2 1 2 4 4 4 0 TSC-22/dip/bun family Surfac_D-trimer PF09006.6 KOO29052.1 - 0.27 10.9 2.6 1.2 8.9 0.0 2.7 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation DUF3584 PF12128.3 KOO29052.1 - 0.61 7.3 34.0 1.1 6.4 23.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ATP-grasp_4 PF13535.1 KOO29053.1 - 3.9e-14 52.7 0.0 6.8e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.12 KOO29053.1 - 9.6e-06 25.0 0.0 0.13 11.5 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain ATPgrasp_Ter PF15632.1 KOO29053.1 - 0.0051 15.6 0.0 1.4 7.5 0.0 2.5 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon CH PF00307.26 KOO29054.1 - 4.1e-24 84.6 0.0 9.6e-13 48.1 0.1 2.6 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.3 KOO29054.1 - 1.5e-05 24.5 0.0 0.00027 20.5 0.0 2.5 2 0 0 2 2 2 1 CAMSAP CH domain Macoilin PF09726.4 KOO29054.1 - 5.2 5.2 7.5 0.15 10.2 0.6 1.7 3 0 0 3 3 3 0 Transmembrane protein EF-hand_1 PF00036.27 KOO29055.1 - 2.8e-12 44.9 0.3 0.0021 17.2 0.0 4.5 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.1 KOO29055.1 - 4e-12 44.9 0.0 0.0012 18.5 0.0 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.1 KOO29055.1 - 2.5e-09 36.0 1.1 0.0057 15.9 0.0 3.7 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.1 KOO29055.1 - 3.1e-07 30.4 0.1 2.2e-05 24.4 0.1 2.6 1 1 1 2 2 2 2 EF-hand domain pair PipA PF07108.6 KOO29055.1 - 0.0011 18.3 0.2 1.1 8.5 0.0 2.2 2 0 0 2 2 2 2 PipA protein EF-hand_8 PF13833.1 KOO29055.1 - 0.0013 18.2 0.0 11 5.6 0.0 4.0 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_9 PF14658.1 KOO29055.1 - 0.005 16.7 0.0 4 7.4 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain DUF2780 PF11075.3 KOO29055.1 - 0.11 12.5 4.9 2.5 8.1 0.4 2.6 1 1 1 2 2 2 0 Protein of unknown function VcgC/VcgE (DUF2780) VCBS PF13517.1 KOO29056.1 - 4e-154 501.1 179.3 1.4e-14 54.2 4.6 15.5 3 3 12 15 15 15 15 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO29056.1 - 9.1e-84 273.4 172.5 1.1e-06 28.0 0.1 17.6 17 0 0 17 17 17 17 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO29056.1 - 3.2e-30 104.8 72.9 0.11 11.9 0.1 17.1 2 2 15 17 17 17 16 Insecticide toxin TcdB middle/N-terminal region DUF3459 PF11941.3 KOO29056.1 - 1.4 9.0 16.5 1.3e+02 2.7 0.1 9.0 5 3 2 8 8 8 0 Domain of unknown function (DUF3459) Peptidase_S9 PF00326.16 KOO29057.1 - 1.5e-38 132.2 0.0 2.3e-38 131.5 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.10 KOO29057.1 - 3.2e-12 45.7 0.0 5.8e-11 41.6 0.0 2.4 1 1 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain NO_synthase PF02898.10 KOO29058.1 - 7.2e-96 321.1 0.0 1e-95 320.5 0.0 1.1 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain FAD_binding_1 PF00667.15 KOO29058.1 - 1.6e-17 63.7 0.0 8.7e-17 61.2 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.16 KOO29058.1 - 3e-12 47.0 0.0 6e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_1 PF00258.20 KOO29058.1 - 3.2e-09 36.9 0.0 1e-08 35.3 0.0 1.9 1 1 0 1 1 1 1 Flavodoxin Nucleoporin_FG PF13634.1 KOO29059.1 - 0.031 14.5 5.3 0.075 13.2 3.7 1.6 1 0 0 1 1 1 0 Nucleoporin FG repeat region SET_assoc PF11767.3 KOO29060.1 - 5.4e-10 38.4 1.4 7.3 5.9 0.0 8.2 6 2 2 8 8 8 4 Histone lysine methyltransferase SET associated Trichoplein PF13868.1 KOO29060.1 - 0.23 9.7 1.0 0.4 9.0 0.7 1.2 1 0 0 1 1 1 0 Tumour suppressor, Mitostatin MORN PF02493.15 KOO29062.1 - 1.3e-60 197.6 62.4 2.6e-07 29.9 0.4 11.1 11 0 0 11 11 11 10 MORN repeat DUF448 PF04296.8 KOO29062.1 - 0.057 13.0 1.1 1.6 8.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF448) p25-alpha PF05517.7 KOO29062.1 - 0.27 11.4 2.3 1.5 9.0 0.0 2.6 3 1 0 3 3 3 0 p25-alpha Ribosomal_L21e PF01157.13 KOO29063.1 - 4.3e-34 116.2 2.6 6.2e-34 115.7 1.8 1.2 1 0 0 1 1 1 1 Ribosomal protein L21e ShK PF01549.19 KOO29064.1 - 1.1e-07 32.0 8.6 2e-07 31.2 5.9 1.5 1 0 0 1 1 1 1 ShK domain-like 2OG-FeII_Oxy_3 PF13640.1 KOO29064.1 - 1.6e-06 28.5 0.1 3.2e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO29064.1 - 0.00098 19.3 0.0 0.0023 18.1 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Chloroa_b-bind PF00504.16 KOO29066.1 - 2.4e-36 125.3 0.2 3.3e-36 124.8 0.2 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein AA_permease PF00324.16 KOO29066.1 - 0.082 11.2 0.4 0.12 10.6 0.3 1.2 1 0 0 1 1 1 0 Amino acid permease HMGL-like PF00682.14 KOO29067.1 - 3.5e-13 49.7 0.2 4.4e-13 49.4 0.1 1.1 1 0 0 1 1 1 1 HMGL-like Pkinase PF00069.20 KOO29068.1 - 3.3e-51 173.9 0.0 4.3e-51 173.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29068.1 - 9e-30 103.5 0.0 1.6e-29 102.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase IPK PF03770.11 KOO29068.1 - 1.7e-13 50.6 0.0 3e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Inositol polyphosphate kinase Kinase-like PF14531.1 KOO29068.1 - 8.3e-05 21.6 0.0 0.00018 20.5 0.0 1.6 1 0 0 1 1 1 1 Kinase-like AAA_5 PF07728.9 KOO29069.1 - 2.5e-06 27.2 0.0 0.0022 17.6 0.0 3.3 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA PF00004.24 KOO29069.1 - 1.1e-05 25.6 0.0 0.21 11.8 0.0 3.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOO29069.1 - 0.00023 21.3 0.0 0.064 13.4 0.0 3.2 3 0 0 3 3 3 1 AAA domain Sigma54_activ_2 PF14532.1 KOO29069.1 - 0.0018 18.3 0.0 3.3 7.7 0.0 3.7 3 0 0 3 3 3 1 Sigma-54 interaction domain UPF0079 PF02367.12 KOO29069.1 - 0.32 10.6 0.1 1.4 8.5 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 RNA_helicase PF00910.17 KOO29069.1 - 1.2 9.3 0.0 54 4.0 0.0 2.5 2 0 0 2 2 2 0 RNA helicase KAP_NTPase PF07693.9 KOO29069.1 - 2.8 6.8 0.0 5 6.0 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain KaiC PF06745.8 KOO29069.1 - 6.2 5.8 0.0 26 3.8 0.0 1.9 2 0 0 2 2 2 0 KaiC Histone_HNS PF00816.16 KOO29070.1 - 0.18 12.3 9.3 3 8.4 2.0 2.5 2 0 0 2 2 2 0 H-NS histone family DUF566 PF04484.7 KOO29070.1 - 1.1 8.6 9.1 1.6 8.1 6.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF566) PIF1 PF05970.9 KOO29071.1 - 1.5e-27 96.5 0.0 2.7e-27 95.6 0.0 1.4 1 0 0 1 1 1 1 PIF1-like helicase Helitron_like_N PF14214.1 KOO29071.1 - 6.9e-21 74.8 0.6 1.4e-20 73.8 0.4 1.5 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus AAA_30 PF13604.1 KOO29071.1 - 3.7e-12 46.2 0.0 1.8e-11 43.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOO29071.1 - 0.0013 18.4 0.1 0.005 16.5 0.0 2.0 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 KOO29071.1 - 0.002 18.1 0.6 0.014 15.3 0.1 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 KOO29071.1 - 0.0033 17.5 0.1 0.014 15.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.1 KOO29071.1 - 0.0041 17.2 0.0 0.015 15.3 0.0 2.0 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain DUF3296 PF11726.3 KOO29071.1 - 0.011 15.3 0.4 0.03 13.8 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3296) AAA_5 PF07728.9 KOO29071.1 - 0.019 14.7 0.0 0.038 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.13 KOO29071.1 - 0.046 13.2 0.0 3.2 7.2 0.0 2.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase CDC45 PF02724.9 KOO29071.1 - 6.6 4.6 10.9 7.3 4.5 0.2 2.2 2 0 0 2 2 2 0 CDC45-like protein cNMP_binding PF00027.24 KOO29072.1 - 8.8e-37 124.8 0.2 3.6e-17 61.9 0.0 2.6 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain PAN_1 PF00024.21 KOO29073.1 - 0.034 13.9 1.5 0.076 12.7 1.0 1.6 1 0 0 1 1 1 0 PAN domain PAN_4 PF14295.1 KOO29073.1 - 0.34 10.6 21.1 18 5.1 14.6 3.3 1 1 0 1 1 1 0 PAN domain HSF_DNA-bind PF00447.12 KOO29074.1 - 2.1e-25 88.8 0.0 1.3e-21 76.7 0.0 2.3 2 0 0 2 2 2 2 HSF-type DNA-binding PAS_9 PF13426.1 KOO29074.1 - 1.6e-21 76.6 0.0 6.6e-13 48.9 0.0 2.3 2 0 0 2 2 2 2 PAS domain PAS_8 PF13188.1 KOO29074.1 - 6.7e-11 41.6 0.0 0.00019 21.1 0.0 2.7 3 0 0 3 3 3 2 PAS domain PAS PF00989.19 KOO29074.1 - 7.3e-09 35.4 0.0 0.0011 18.7 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.5 KOO29074.1 - 1.5e-07 31.4 0.0 0.00077 19.4 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_3 PF08447.6 KOO29074.1 - 0.018 15.0 0.0 8.2 6.6 0.0 2.4 2 0 0 2 2 2 0 PAS fold Lipase_GDSL_2 PF13472.1 KOO29075.1 - 0.028 14.5 0.0 0.048 13.7 0.0 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family GILT PF03227.11 KOO29078.1 - 2.5e-05 24.1 0.6 0.00092 19.0 0.0 3.0 4 0 0 4 4 4 1 Gamma interferon inducible lysosomal thiol reductase (GILT) TPR_11 PF13414.1 KOO29079.1 - 2.1e-10 40.0 3.0 2.1e-10 40.0 2.1 1.7 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.12 KOO29079.1 - 1.2e-08 34.2 4.6 0.004 16.9 0.2 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO29079.1 - 6.8e-06 25.4 1.2 0.055 13.1 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO29079.1 - 8.5e-05 22.4 5.0 9.3e-05 22.2 2.3 1.9 1 1 1 2 2 2 1 Tetratricopeptide repeat SAM_2 PF07647.12 KOO29079.1 - 0.0017 18.1 0.0 0.0034 17.2 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) TPR_8 PF13181.1 KOO29079.1 - 0.0018 17.9 0.4 0.27 11.1 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat SAM_1 PF00536.25 KOO29079.1 - 0.0036 17.4 0.1 0.01 16.0 0.0 1.9 3 0 0 3 3 2 1 SAM domain (Sterile alpha motif) TPR_16 PF13432.1 KOO29079.1 - 0.007 17.0 5.1 0.007 17.0 3.5 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO29079.1 - 0.029 15.0 9.7 0.55 11.0 0.5 3.6 1 1 2 3 3 3 0 Tetratricopeptide repeat TerB-C PF15615.1 KOO29079.1 - 0.029 14.6 0.1 0.051 13.8 0.1 1.5 1 0 0 1 1 1 0 TerB-C domain TPR_7 PF13176.1 KOO29079.1 - 0.35 10.7 1.9 0.97 9.3 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Ank_2 PF12796.2 KOO29080.1 - 6.7e-25 87.2 4.2 9.7e-10 38.6 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO29080.1 - 2.2e-21 75.7 2.7 2.2e-06 28.0 0.1 4.0 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.25 KOO29080.1 - 2.9e-19 67.8 3.0 0.00045 19.8 0.1 5.0 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.1 KOO29080.1 - 2.4e-16 59.3 11.5 1.5e-06 28.2 0.4 3.9 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO29080.1 - 2.2e-15 55.2 0.4 0.03 14.5 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat CheD PF03975.8 KOO29080.1 - 0.014 15.1 0.1 0.079 12.7 0.1 2.0 1 1 1 2 2 2 0 CheD chemotactic sensory transduction UBA PF00627.26 KOO29080.1 - 0.017 14.9 1.5 0.21 11.4 0.0 3.0 3 0 0 3 3 3 0 UBA/TS-N domain PTS_IIA PF02255.11 KOO29080.1 - 0.028 14.2 0.3 0.11 12.3 0.0 2.0 2 1 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIA subunit DUF4226 PF10774.4 KOO29080.1 - 0.035 14.1 0.7 0.096 12.7 0.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4226) Sulfate_transp PF00916.15 KOO29081.1 - 1.4e-54 185.0 16.6 1.4e-54 185.0 11.5 1.5 2 0 0 2 2 2 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 KOO29081.1 - 1.1e-23 82.7 7.4 1.1e-23 82.7 5.1 4.2 5 2 0 5 5 5 1 Sulfate transporter N-terminal domain with GLY motif ADH_N PF08240.7 KOO29082.1 - 5e-21 74.5 1.7 1.4e-20 73.0 1.2 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 KOO29082.1 - 2.6e-10 39.9 1.9 5.2e-10 38.9 0.1 2.3 3 0 0 3 3 3 1 Zinc-binding dehydrogenase PALP PF00291.20 KOO29082.1 - 0.001 18.3 0.2 0.0016 17.7 0.1 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme FAD_binding_3 PF01494.14 KOO29082.1 - 0.078 12.0 0.1 0.11 11.5 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain AlaDh_PNT_C PF01262.16 KOO29082.1 - 0.13 11.7 1.5 0.18 11.3 0.1 1.9 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain RdRP PF05183.7 KOO29083.1 - 2e-28 99.4 0.0 1.7e-26 93.1 0.0 2.0 2 0 0 2 2 2 2 RNA dependent RNA polymerase Peptidase_C1 PF00112.18 KOO29084.1 - 3.8e-40 138.0 4.3 5.2e-40 137.6 3.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.10 KOO29084.1 - 0.38 9.2 0.8 1.1 7.7 0.5 1.6 2 0 0 2 2 2 0 Peptidase C1-like family DUF676 PF05057.9 KOO29085.1 - 2.3e-37 128.4 0.0 3.2e-37 127.9 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.2 KOO29085.1 - 6.2e-06 26.2 1.8 1.3e-05 25.2 0.0 2.2 2 1 0 2 2 2 1 Alpha/beta hydrolase family PGAP1 PF07819.8 KOO29085.1 - 0.0001 21.9 0.0 0.00018 21.2 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_5 PF12695.2 KOO29085.1 - 0.0017 18.1 0.0 0.0043 16.8 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family LCAT PF02450.10 KOO29085.1 - 0.16 10.9 0.0 0.32 9.9 0.0 1.4 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase cNMP_binding PF00027.24 KOO29086.1 - 8.9e-12 44.6 0.0 1.5e-07 31.1 0.0 2.7 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain EF-hand_7 PF13499.1 KOO29086.1 - 2.2e-09 37.3 0.0 4.9e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO29086.1 - 5.3e-09 35.2 0.1 3.7e-05 23.2 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO29086.1 - 9.1e-09 34.0 0.0 0.0017 17.5 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO29086.1 - 1.5e-05 24.1 0.0 0.027 13.8 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO29086.1 - 5.6e-05 22.6 0.0 0.00027 20.4 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain pair ATG16 PF08614.6 KOO29086.1 - 0.0074 16.1 3.1 0.0074 16.1 2.2 2.5 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) Phage_GPO PF05929.6 KOO29086.1 - 5.8 6.0 20.3 0.99 8.6 1.8 2.4 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase TMCO5 PF14992.1 KOO29086.1 - 9.4 5.2 20.3 8.4 5.4 6.9 2.3 2 0 0 2 2 2 0 TMCO5 family WD40 PF00400.27 KOO29088.1 - 3.8e-17 61.4 15.7 5.6e-07 29.1 0.4 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat PQQ_3 PF13570.1 KOO29088.1 - 0.0068 16.6 0.8 1.2 9.4 0.0 4.2 4 0 0 4 4 4 1 PQQ-like domain Spc7 PF08317.6 KOO29088.1 - 2.3 6.8 7.9 3.3 6.2 5.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Ank_2 PF12796.2 KOO29089.1 - 1.4e-66 220.8 36.2 1.1e-13 51.3 0.8 7.2 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank PF00023.25 KOO29089.1 - 6.1e-65 211.9 38.5 9.5e-07 28.3 0.1 14.3 14 0 0 14 14 14 14 Ankyrin repeat Ank_4 PF13637.1 KOO29089.1 - 9.6e-48 159.7 14.6 5.7e-07 29.8 0.1 9.6 2 2 9 12 12 12 12 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO29089.1 - 1.6e-46 151.6 21.2 0.00049 20.0 0.0 14.3 14 0 0 14 14 14 13 Ankyrin repeat Ank_5 PF13857.1 KOO29089.1 - 7.8e-41 137.1 27.1 1.6e-07 31.2 0.1 10.3 5 4 5 10 10 10 9 Ankyrin repeats (many copies) Shigella_OspC PF06128.6 KOO29089.1 - 0.051 13.0 0.0 12 5.2 0.0 2.8 3 0 0 3 3 3 0 Shigella flexneri OspC protein PPR_3 PF13812.1 KOO29089.1 - 3.2 8.2 0.0 3.2 8.2 0.0 4.3 7 0 0 7 7 7 0 Pentatricopeptide repeat domain PEPCK_ATP PF01293.15 KOO29092.1 - 2.1e-198 659.5 0.0 2.7e-198 659.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.1 KOO29092.1 - 0.046 13.5 0.0 0.099 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 KOO29092.1 - 0.13 11.6 0.0 0.29 10.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_13 PF13166.1 KOO29092.1 - 0.36 9.2 0.0 0.52 8.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain WD40 PF00400.27 KOO29093.1 - 4.6e-24 83.3 8.2 1e-05 25.1 0.0 6.4 8 0 0 8 8 8 4 WD domain, G-beta repeat Nup160 PF11715.3 KOO29093.1 - 0.034 12.2 0.0 0.055 11.6 0.0 1.4 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Kinesin PF00225.18 KOO29094.1 - 5.2e-95 317.9 0.0 7.8e-95 317.3 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain DivIC PF04977.10 KOO29094.1 - 5.1 6.6 7.4 1.4 8.4 0.2 3.3 2 1 2 4 4 4 0 Septum formation initiator Dynamin_N PF00350.18 KOO29095.1 - 1.9e-22 79.8 0.0 3.8e-22 78.8 0.0 1.5 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.18 KOO29095.1 - 1.6e-05 24.8 0.0 5.7e-05 23.0 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.11 KOO29095.1 - 0.014 14.5 0.0 0.67 9.0 0.0 2.2 2 0 0 2 2 2 0 AIG1 family FeoB_N PF02421.13 KOO29095.1 - 0.018 14.3 0.0 0.82 8.9 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF892 PF05974.7 KOO29095.1 - 0.039 13.7 0.1 0.089 12.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF892) GTP_EFTU PF00009.22 KOO29095.1 - 0.17 11.3 0.0 0.5 9.7 0.0 1.8 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.1 KOO29095.1 - 0.62 10.0 5.8 0.25 11.2 0.4 2.5 2 2 0 2 2 2 0 AAA ATPase domain Ras PF00071.17 KOO29096.1 - 1.8e-40 137.9 0.0 2.2e-40 137.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO29096.1 - 3.7e-15 56.4 0.0 5.8e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO29096.1 - 3.7e-09 36.0 0.0 5e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KOO29096.1 - 7.3e-05 22.0 0.0 0.0001 21.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.4 KOO29096.1 - 0.072 12.5 0.0 0.18 11.2 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.5 KOO29096.1 - 0.12 11.5 0.0 0.17 11.1 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Orai-1 PF07856.7 KOO29097.1 - 0.061 12.8 5.0 0.25 10.9 3.5 1.8 1 1 0 1 1 1 0 Mediator of CRAC channel activity Kinesin PF00225.18 KOO29098.1 - 7.9e-76 254.9 0.0 1.9e-75 253.6 0.0 1.6 2 0 0 2 2 2 1 Kinesin motor domain Bacillus_HBL PF05791.6 KOO29098.1 - 2.5 7.4 9.9 0.49 9.7 4.0 1.9 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF972 PF06156.8 KOO29098.1 - 6.1 7.2 13.2 2.5 8.4 2.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Pkinase PF00069.20 KOO29099.1 - 7.2e-71 238.3 0.0 8.2e-71 238.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29099.1 - 1.9e-32 112.3 0.0 2.4e-32 112.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO29099.1 - 0.012 14.5 0.0 0.23 10.3 0.0 2.2 1 1 1 2 2 2 0 Kinase-like Lactamase_B_2 PF12706.2 KOO29100.1 - 1.8e-13 50.5 0.0 2.5e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 KOO29100.1 - 3.5e-05 23.5 0.2 0.00012 21.7 0.0 1.9 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily DBC1 PF14443.1 KOO29101.1 - 0.0023 17.4 0.1 0.01 15.3 0.0 2.0 2 0 0 2 2 2 1 DBC1 Glyco_trans_1_2 PF13524.1 KOO29101.1 - 0.071 13.3 0.5 7.6 6.8 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferases group 1 Ion_trans PF00520.26 KOO29102.1 - 6e-27 94.2 12.3 8.5e-27 93.7 8.5 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.7 KOO29102.1 - 0.018 13.4 16.4 0.1 10.9 8.0 3.0 2 1 0 2 2 2 0 Polycystin cation channel PG_binding_1 PF01471.13 KOO29103.1 - 2.6e-06 27.3 0.1 5.8e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Putative peptidoglycan binding domain ZZ PF00569.12 KOO29103.1 - 0.00023 20.6 0.3 0.00039 19.9 0.2 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type DUF4632 PF15451.1 KOO29103.1 - 0.038 13.9 0.3 0.12 12.3 0.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4632) PG_binding_3 PF09374.5 KOO29103.1 - 0.051 13.5 0.0 0.095 12.6 0.0 1.4 1 0 0 1 1 1 0 Predicted Peptidoglycan domain LRR_6 PF13516.1 KOO29104.1 - 1.5e-22 77.0 3.5 0.0011 18.7 0.0 6.8 6 0 0 6 6 6 5 Leucine Rich repeat Ank_2 PF12796.2 KOO29104.1 - 8.7e-21 74.0 1.0 1.9e-14 53.7 0.2 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO29104.1 - 6.5e-19 66.7 1.2 3.9e-08 32.6 0.1 3.9 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 KOO29104.1 - 1.2e-16 60.7 0.8 5.2e-07 29.9 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO29104.1 - 1.8e-15 56.6 3.4 6.7e-09 35.7 0.1 3.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO29104.1 - 3.5e-15 54.6 1.2 0.0004 20.3 0.0 4.8 4 0 0 4 4 4 2 Ankyrin repeat CbiG_N PF11760.3 KOO29104.1 - 0.059 13.0 4.0 28 4.5 0.0 4.5 4 0 0 4 4 4 0 Cobalamin synthesis G N-terminal Peptidase_C9 PF01707.11 KOO29104.1 - 0.15 11.6 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 Peptidase family C9 SpoU_sub_bind PF08032.7 KOO29104.1 - 4.7 7.4 6.9 48 4.2 0.1 4.4 4 1 2 6 6 6 0 RNA 2'-O ribose methyltransferase substrate binding Imm19 PF15567.1 KOO29105.1 - 0.023 14.6 0.0 0.075 13.0 0.0 1.8 2 0 0 2 2 2 0 Immunity protein 19 Fringe PF02434.11 KOO29106.1 - 2.7e-25 89.0 0.0 6e-25 87.9 0.0 1.5 1 1 0 1 1 1 1 Fringe-like DUF604 PF04646.7 KOO29106.1 - 0.011 15.0 0.0 0.02 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF604 Renin_r PF07850.9 KOO29110.1 - 0.0049 17.1 4.5 0.0064 16.8 1.7 1.8 1 1 0 2 2 2 1 Renin receptor-like protein TMEM107 PF14995.1 KOO29110.1 - 0.091 12.8 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Transmembrane protein SVM_signal PF12113.3 KOO29110.1 - 0.3 10.9 1.5 0.42 10.4 1.1 1.2 1 0 0 1 1 1 0 SVM protein signal sequence SAP PF02037.22 KOO29111.1 - 2.3e-15 55.6 1.6 1.9e-07 30.4 0.1 2.6 2 0 0 2 2 2 2 SAP domain SURF2 PF05477.6 KOO29111.1 - 0.00067 18.8 0.0 0.0011 18.1 0.0 1.3 1 0 0 1 1 1 1 Surfeit locus protein 2 (SURF2) HeH PF12949.2 KOO29111.1 - 0.053 13.0 0.3 6.3 6.4 0.0 2.6 2 0 0 2 2 2 0 HeH/LEM domain Mito_carr PF00153.22 KOO29112.1 - 4.4e-50 167.3 0.3 3.2e-16 58.7 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.27 KOO29112.1 - 0.11 11.8 0.4 0.48 9.8 0.0 2.3 3 0 0 3 3 3 0 EF hand zf-RING_2 PF13639.1 KOO29113.1 - 1.6e-08 34.2 9.6 4e-08 32.9 6.7 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 KOO29113.1 - 2.1e-07 30.5 7.9 5.2e-07 29.2 5.5 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 KOO29113.1 - 3e-06 27.1 9.9 8.6e-06 25.6 6.8 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Glycos_transf_1 PF00534.15 KOO29113.1 - 7.5e-06 25.4 0.0 0.028 13.8 0.0 2.3 1 1 1 2 2 2 2 Glycosyl transferases group 1 zf-C3HC4_3 PF13920.1 KOO29113.1 - 3.8e-05 23.2 7.8 9.4e-05 22.0 5.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO29113.1 - 8.2e-05 22.1 8.6 0.00019 20.9 5.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 KOO29113.1 - 0.0011 18.7 12.1 0.003 17.4 6.6 3.0 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 KOO29113.1 - 0.0057 16.3 7.9 0.011 15.4 1.2 3.0 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_4 PF14570.1 KOO29113.1 - 0.0067 15.9 6.5 0.021 14.3 4.5 1.9 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain DUF1323 PF07037.6 KOO29114.1 - 0.00058 20.0 9.3 1.2 9.3 0.2 4.0 1 1 3 4 4 4 4 Putative transcription regulator (DUF1323) DUF4599 PF15371.1 KOO29114.1 - 6.9 6.8 8.0 43 4.2 0.3 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4599) HTH_23 PF13384.1 KOO29115.1 - 0.0006 19.3 0.1 0.0017 17.9 0.0 1.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.1 KOO29115.1 - 0.004 17.1 0.0 0.014 15.3 0.0 2.0 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.1 KOO29115.1 - 0.04 13.1 0.0 0.077 12.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_7 PF02796.10 KOO29115.1 - 0.06 13.2 0.0 0.64 9.9 0.0 2.3 1 1 1 2 2 2 0 Helix-turn-helix domain of resolvase HTH_29 PF13551.1 KOO29115.1 - 0.068 13.3 0.1 0.23 11.6 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn helix Ion_trans PF00520.26 KOO29116.1 - 4.8e-132 437.2 57.2 1.1e-41 142.3 1.8 4.5 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 KOO29116.1 - 6.8e-09 34.6 58.1 1.4e-05 23.6 2.5 7.6 6 3 2 8 8 8 6 Polycystin cation channel FAM176 PF14851.1 KOO29116.1 - 0.076 12.6 0.1 2.1 8.0 0.0 3.1 3 0 0 3 3 3 0 FAM176 family Glutaredoxin PF00462.19 KOO29117.1 - 4.9e-17 61.6 0.0 8.8e-17 60.8 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.1 KOO29117.1 - 0.00018 21.6 0.0 0.00038 20.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Phosphoesterase PF04185.9 KOO29118.1 - 1.4e-55 189.0 0.3 3.4e-55 187.7 0.2 1.5 1 1 0 1 1 1 1 Phosphoesterase family cobW PF02492.14 KOO29119.1 - 8.3e-49 165.4 0.3 1.3e-48 164.8 0.2 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 KOO29119.1 - 1.7e-22 78.9 0.1 3.4e-22 77.9 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_28 PF13521.1 KOO29119.1 - 0.041 13.8 0.0 0.092 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 KOO29119.1 - 0.056 13.3 0.0 0.15 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 KOO29119.1 - 0.058 12.8 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain UPF0079 PF02367.12 KOO29119.1 - 0.066 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 MobB PF03205.9 KOO29119.1 - 0.069 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Viral_helicase1 PF01443.13 KOO29119.1 - 0.083 12.3 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase MMR_HSR1 PF01926.18 KOO29119.1 - 0.095 12.6 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.1 KOO29119.1 - 0.1 12.7 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 KOO29119.1 - 0.12 12.6 0.0 0.32 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 KOO29119.1 - 0.13 11.3 0.1 0.35 9.9 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_14 PF13173.1 KOO29119.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 KOO29119.1 - 0.14 11.3 0.0 0.27 10.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 CbiA PF01656.18 KOO29119.1 - 0.15 11.4 0.0 0.29 10.5 0.0 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ABC_tran PF00005.22 KOO29119.1 - 0.16 12.2 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Arch_ATPase PF01637.13 KOO29119.1 - 0.25 11.0 0.0 0.43 10.2 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase PDZ PF00595.19 KOO29121.1 - 0.00012 22.2 0.0 0.00021 21.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO29121.1 - 0.0078 16.0 0.2 0.013 15.3 0.1 1.3 1 0 0 1 1 1 1 PDZ domain DUF2880 PF11082.3 KOO29123.1 - 0.12 12.2 1.1 1 9.3 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2880) EF-hand_1 PF00036.27 KOO29124.1 - 0.034 13.4 0.0 0.088 12.1 0.0 1.7 1 0 0 1 1 1 0 EF hand EF-hand_5 PF13202.1 KOO29124.1 - 0.068 12.5 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 EF hand EF-hand_4 PF12763.2 KOO29124.1 - 0.17 11.6 0.0 0.37 10.5 0.0 1.5 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.1 KOO29125.1 - 4.7e-23 81.1 0.2 9.9e-11 41.6 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO29125.1 - 9.9e-23 77.6 1.5 2.3e-05 23.3 0.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO29125.1 - 1e-15 56.1 0.8 0.0023 17.6 0.0 4.8 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.1 KOO29125.1 - 9.1e-13 46.9 0.1 0.00083 18.5 0.0 4.6 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO29125.1 - 6.1e-11 41.7 7.2 0.026 14.1 0.0 4.5 2 2 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO29125.1 - 0.00041 20.3 0.1 1.1 9.3 0.0 2.7 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO29125.1 - 0.0037 16.9 0.0 2.4 7.9 0.0 2.6 2 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Gon7 PF08738.5 KOO29126.1 - 0.13 12.2 0.3 0.31 11.0 0.0 1.7 2 0 0 2 2 2 0 Gon7 family Cupin_8 PF13621.1 KOO29127.1 - 1.3e-31 110.0 0.0 3e-31 108.8 0.0 1.6 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.17 KOO29127.1 - 0.0015 18.8 0.0 0.0031 17.7 0.0 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_4 PF08007.7 KOO29127.1 - 0.0017 17.6 0.1 0.024 13.8 0.0 2.2 1 1 0 1 1 1 1 Cupin superfamily protein DUF2475 PF10629.4 KOO29131.1 - 0.011 15.9 0.7 3.5 7.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2475) DUF1032 PF06278.6 KOO29132.1 - 1.3e-31 109.7 15.3 5.9e-18 64.6 3.4 5.0 3 1 1 4 4 4 4 Protein of unknown function (DUF1032) Cnd2 PF05786.9 KOO29132.1 - 0.00085 17.9 0.1 0.00085 17.9 0.1 1.9 2 0 0 2 2 2 1 Condensin complex subunit 2 AnfO_nitrog PF09582.5 KOO29132.1 - 0.13 11.3 1.0 0.26 10.4 0.7 1.4 1 0 0 1 1 1 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) ECH PF00378.15 KOO29133.1 - 1.2e-72 244.0 1.3 1.4e-72 243.8 0.9 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family ECH_C PF13766.1 KOO29133.1 - 0.0075 16.3 0.1 0.016 15.3 0.1 1.6 1 1 0 1 1 1 1 2-enoyl-CoA Hydratase C-terminal region Peptidase_S49 PF01343.13 KOO29133.1 - 0.025 14.3 0.3 3.6 7.3 0.0 2.5 2 0 0 2 2 2 0 Peptidase family S49 TetR_C_9 PF14514.1 KOO29133.1 - 0.079 12.7 0.0 0.82 9.4 0.0 2.1 2 0 0 2 2 2 0 Transcriptional regulator, TetR, C-terminal DLH PF01738.13 KOO29133.1 - 0.098 11.9 0.2 0.16 11.1 0.2 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family Cupin_8 PF13621.1 KOO29134.1 - 3e-25 89.1 0.0 3.5e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 KOO29134.1 - 0.0013 18.0 0.2 0.012 14.8 0.1 2.3 2 1 0 2 2 2 1 Cupin superfamily protein Peptidase_A22B PF04258.8 KOO29135.1 - 1.7e-76 257.5 11.0 2e-76 257.2 7.6 1.1 1 0 0 1 1 1 1 Signal peptide peptidase DUF1119 PF06550.6 KOO29135.1 - 0.00026 20.2 16.6 0.0003 20.0 7.6 2.8 2 1 0 2 2 2 1 Protein of unknown function (DUF1119) LRR_4 PF12799.2 KOO29137.1 - 2.1e-72 237.8 53.7 5e-08 32.3 0.8 14.6 11 2 2 14 14 14 13 Leucine Rich repeats (2 copies) LRR_9 PF14580.1 KOO29137.1 - 9.2e-48 162.0 16.0 2.5e-13 49.9 1.1 6.6 3 2 4 7 7 7 7 Leucine-rich repeat LRR_8 PF13855.1 KOO29137.1 - 1.1e-44 149.9 70.3 9.4e-09 34.9 0.9 12.2 9 4 3 13 13 13 10 Leucine rich repeat LRR_1 PF00560.28 KOO29137.1 - 1.5e-08 33.5 61.7 0.21 11.7 0.2 18.7 19 2 1 20 20 20 4 Leucine Rich Repeat LRR_6 PF13516.1 KOO29137.1 - 0.0029 17.5 59.7 2.4 8.4 0.0 15.8 13 4 5 18 18 18 4 Leucine Rich repeat LRR_7 PF13504.1 KOO29137.1 - 0.01 15.8 64.2 6.4 7.4 0.1 19.2 20 2 0 20 20 20 0 Leucine rich repeat Macoilin PF09726.4 KOO29137.1 - 0.23 9.6 0.2 0.39 8.9 0.1 1.2 1 0 0 1 1 1 0 Transmembrane protein DUF2365 PF10157.4 KOO29138.1 - 2.1e-10 40.6 0.1 2.3e-10 40.5 0.1 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2365) DUF2388 PF09498.5 KOO29138.1 - 0.03 13.9 0.6 0.046 13.3 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2388) AAA PF00004.24 KOO29139.1 - 1.4e-43 148.2 0.0 3.2e-43 147.0 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KOO29139.1 - 1.1e-08 34.8 0.2 4.7e-08 32.8 0.1 2.1 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 KOO29139.1 - 7e-07 29.4 0.2 5.8e-05 23.2 0.1 2.8 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.9 KOO29139.1 - 9.7e-07 28.8 0.1 3.1e-06 27.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 KOO29139.1 - 1.8e-06 28.0 0.1 1.6e-05 24.9 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.8 KOO29139.1 - 3.4e-05 22.9 0.0 7.1e-05 21.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_19 PF13245.1 KOO29139.1 - 0.00018 21.1 0.2 0.00043 19.9 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_28 PF13521.1 KOO29139.1 - 0.0002 21.3 0.0 0.00054 19.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 KOO29139.1 - 0.00022 20.3 0.0 0.00042 19.4 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.12 KOO29139.1 - 0.00024 20.5 0.0 0.00058 19.3 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_17 PF13207.1 KOO29139.1 - 0.00047 20.9 0.0 0.0017 19.1 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_25 PF13481.1 KOO29139.1 - 0.00062 19.2 2.0 0.011 15.1 0.1 2.4 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.8 KOO29139.1 - 0.00068 18.4 0.0 0.002 16.8 0.0 1.6 1 1 1 2 2 2 1 TIP49 C-terminus RNA_helicase PF00910.17 KOO29139.1 - 0.00094 19.3 0.0 0.0048 17.0 0.0 2.2 2 0 0 2 2 2 1 RNA helicase Mg_chelatase PF01078.16 KOO29139.1 - 0.0014 17.8 0.1 0.0032 16.6 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 KOO29139.1 - 0.0035 17.2 0.0 0.0084 15.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 KOO29139.1 - 0.0037 16.9 0.1 0.066 12.8 0.0 2.3 2 0 0 2 2 2 1 NACHT domain AAA_14 PF13173.1 KOO29139.1 - 0.0037 17.1 0.0 0.009 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOO29139.1 - 0.0054 17.0 0.0 0.014 15.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 KOO29139.1 - 0.0062 16.1 0.1 0.013 15.0 0.1 1.5 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOO29139.1 - 0.011 14.7 0.0 0.023 13.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_11 PF13086.1 KOO29139.1 - 0.013 15.0 0.0 0.048 13.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.1 KOO29139.1 - 0.014 14.9 0.0 0.044 13.3 0.0 1.8 2 0 0 2 2 1 0 AAA domain Sigma54_activat PF00158.21 KOO29139.1 - 0.015 14.8 0.1 0.15 11.4 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain Parvo_NS1 PF01057.12 KOO29139.1 - 0.017 13.9 0.0 0.033 13.0 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 UPF0079 PF02367.12 KOO29139.1 - 0.02 14.4 0.0 0.064 12.8 0.0 1.7 1 1 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_3 PF07726.6 KOO29139.1 - 0.024 14.2 0.0 0.051 13.1 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.10 KOO29139.1 - 0.028 14.1 0.1 0.1 12.3 0.0 2.0 2 0 0 2 2 2 0 NTPase GrpE PF01025.14 KOO29139.1 - 0.042 13.3 0.1 0.51 9.8 0.0 2.2 2 0 0 2 2 2 0 GrpE KaiC PF06745.8 KOO29139.1 - 0.072 12.2 0.8 0.38 9.8 0.0 2.3 3 0 0 3 3 3 0 KaiC Arch_ATPase PF01637.13 KOO29139.1 - 0.072 12.7 0.4 1.1 8.8 0.0 2.3 2 1 1 3 3 2 0 Archaeal ATPase AAA_23 PF13476.1 KOO29139.1 - 0.076 13.3 0.1 2.8 8.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain PhoH PF02562.11 KOO29139.1 - 0.078 12.2 0.1 0.17 11.0 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Sigma54_activ_2 PF14532.1 KOO29139.1 - 0.091 12.8 0.0 0.25 11.4 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain NB-ARC PF00931.17 KOO29139.1 - 0.097 11.5 0.0 0.19 10.5 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_10 PF12846.2 KOO29139.1 - 0.14 11.5 0.2 1.2 8.5 0.0 2.1 1 1 0 2 2 2 0 AAA-like domain ABC_tran PF00005.22 KOO29139.1 - 0.16 12.2 0.0 1.2 9.3 0.0 2.4 3 0 0 3 3 2 0 ABC transporter GSHPx PF00255.14 KOO29140.1 - 5.3e-05 22.5 0.0 6.6e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase SAD_SRA PF02182.12 KOO29141.1 - 3.9e-10 39.2 0.0 7.5e-10 38.3 0.0 1.4 1 0 0 1 1 1 1 SAD/SRA domain PsbU PF06514.6 KOO29142.1 - 5.8e-32 109.3 0.5 7.7e-32 109.0 0.3 1.1 1 0 0 1 1 1 1 Photosystem II 12 kDa extrinsic protein (PsbU) HHH_3 PF12836.2 KOO29142.1 - 0.0011 18.8 0.2 0.0057 16.5 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix motif GSHPx PF00255.14 KOO29143.1 - 1.1e-17 63.3 0.0 1.5e-17 62.9 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase ATP-grasp_4 PF13535.1 KOO29144.1 - 5.6e-35 120.7 0.0 9.5e-35 119.9 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 KOO29144.1 - 8.9e-12 44.3 0.0 1.5e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.9 KOO29144.1 - 5.6e-10 39.3 0.0 9.5e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.14 KOO29144.1 - 4e-07 29.7 0.0 6.9e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATPgrasp_ST PF14397.1 KOO29144.1 - 0.0022 17.1 0.0 0.16 10.9 0.0 2.1 1 1 1 2 2 2 2 Sugar-transfer associated ATP-grasp RimK PF08443.6 KOO29144.1 - 0.0041 16.6 0.0 0.0071 15.8 0.0 1.3 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Ion_trans_2 PF07885.11 KOO29146.1 - 2.2e-21 75.3 13.6 1.2e-10 40.9 3.4 2.3 2 0 0 2 2 2 2 Ion channel MORN PF02493.15 KOO29146.1 - 2.2e-11 42.8 13.8 9.7e-09 34.4 0.3 3.8 4 0 0 4 4 4 2 MORN repeat EF-hand_5 PF13202.1 KOO29146.1 - 9.6e-06 24.7 0.3 9.6e-06 24.7 0.2 2.0 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.27 KOO29146.1 - 0.0032 16.6 0.0 0.0032 16.6 0.0 2.2 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.1 KOO29146.1 - 0.0035 17.4 0.0 0.0088 16.1 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO29146.1 - 0.0037 17.0 0.1 0.0037 17.0 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain Ni_hydr_CYTB PF01292.15 KOO29146.1 - 0.046 13.1 5.7 0.069 12.5 4.0 1.3 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 Ion_trans PF00520.26 KOO29146.1 - 0.054 12.7 8.9 0.034 13.3 1.3 2.4 2 1 0 2 2 2 0 Ion transport protein Cytochrom_B_N PF00033.14 KOO29146.1 - 1.9 7.8 9.6 3.2 7.0 6.7 1.4 1 1 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB Phage_GP20 PF06810.6 KOO29148.1 - 5.1 6.5 11.8 0.42 10.0 0.6 3.2 2 1 1 3 3 3 0 Phage minor structural protein GP20 V_ATPase_I PF01496.14 KOO29148.1 - 7.2 4.3 7.1 10 3.8 4.9 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PALP PF00291.20 KOO29149.1 - 1.8e-69 234.3 5.1 2.4e-69 233.9 3.5 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.13 KOO29149.1 - 2.5e-33 113.5 0.0 5e-20 70.8 0.0 2.4 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase SNARE_assoc PF09335.6 KOO29150.1 - 2.8e-13 50.1 6.7 2.8e-13 50.1 4.6 2.1 3 0 0 3 3 3 1 SNARE associated Golgi protein DAO PF01266.19 KOO29151.1 - 9.8e-09 34.5 5.2 1e-06 27.9 0.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase ArfGap PF01412.13 KOO29152.1 - 7e-18 64.5 12.9 6.7e-13 48.4 2.2 2.0 1 1 1 2 2 2 2 Putative GTPase activating protein for Arf RNA_POL_M_15KD PF02150.11 KOO29152.1 - 0.23 11.1 7.8 9.7 5.9 0.1 3.9 4 0 0 4 4 4 0 RNA polymerases M/15 Kd subunit DUF630 PF04783.7 KOO29152.1 - 1.5 8.7 4.5 16 5.5 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF630) Subtilosin_A PF11420.3 KOO29152.1 - 2.1 8.4 6.7 16 5.6 0.5 2.5 2 0 0 2 2 2 0 Bacteriocin subtilosin A PhnA_Zn_Ribbon PF08274.7 KOO29152.1 - 2.1 8.1 13.4 6.2 6.7 0.1 4.1 4 0 0 4 4 4 0 PhnA Zinc-Ribbon Adeno_E4_34 PF04528.8 KOO29152.1 - 2.9 7.4 10.7 1.2 8.7 1.3 2.1 2 0 0 2 2 2 0 Adenovirus early E4 34 kDa protein conserved region Filamin PF00630.14 KOO29154.1 - 2.4e-85 281.6 0.0 2.8e-11 43.8 0.0 10.3 9 1 0 9 9 9 9 Filamin/ABP280 repeat YtkA PF13115.1 KOO29154.1 - 9.6e-05 22.6 0.1 4.5 7.6 0.0 5.8 6 0 0 6 6 6 1 YtkA-like Big_1 PF02369.11 KOO29154.1 - 0.00048 19.9 1.7 0.75 9.7 0.0 4.4 4 0 0 4 4 4 1 Bacterial Ig-like domain (group 1) Neurexophilin PF06312.7 KOO29154.1 - 0.0021 17.3 0.0 0.096 11.9 0.0 2.8 3 0 0 3 3 3 1 Neurexophilin EF-hand_1 PF00036.27 KOO29155.1 - 2.8e-22 76.2 2.4 4.5e-07 28.7 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_5 PF13202.1 KOO29155.1 - 1.9e-19 68.0 2.8 3.3e-06 26.1 0.1 3.4 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 KOO29155.1 - 5.1e-19 66.3 1.3 3.1e-06 26.5 0.0 3.8 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.1 KOO29155.1 - 4.2e-18 65.2 0.0 1.4e-05 25.0 0.0 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO29155.1 - 2.7e-16 58.9 2.0 0.00039 19.9 0.1 3.4 3 1 0 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO29155.1 - 8.2e-07 29.0 0.3 0.0027 17.7 0.1 2.9 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO29155.1 - 0.00071 19.2 0.4 0.66 9.7 0.0 2.8 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO29155.1 - 0.0039 17.0 0.0 0.16 11.9 0.0 2.7 2 1 0 2 2 2 1 EF-hand domain EF-hand_10 PF14788.1 KOO29155.1 - 0.0082 15.7 1.6 3.3 7.4 0.0 3.5 3 1 1 4 4 4 1 EF hand p25-alpha PF05517.7 KOO29155.1 - 0.031 14.5 1.7 2.8 8.1 0.0 2.2 2 0 0 2 2 2 0 p25-alpha MT-A70 PF05063.9 KOO29157.1 - 1.4e-56 190.8 0.1 2.1e-56 190.2 0.1 1.3 1 0 0 1 1 1 1 MT-A70 Methyltransf_26 PF13659.1 KOO29157.1 - 0.012 15.6 0.0 0.028 14.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DUF4456 PF14644.1 KOO29157.1 - 0.049 12.8 0.1 0.078 12.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4456) NCD1 PF04904.8 KOO29157.1 - 0.067 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 NAB conserved region 1 (NCD1) zf-CCCH_2 PF14608.1 KOO29157.1 - 0.22 11.5 1.2 0.44 10.6 0.8 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type Rootletin PF15035.1 KOO29159.1 - 0.0094 15.9 13.1 0.022 14.7 6.1 2.2 2 0 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion Tropomyosin PF00261.15 KOO29159.1 - 0.083 11.9 17.5 0.13 11.3 12.2 1.3 1 0 0 1 1 1 0 Tropomyosin Reo_sigmaC PF04582.7 KOO29159.1 - 0.095 11.8 4.1 0.28 10.3 2.4 1.9 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Spc7 PF08317.6 KOO29159.1 - 0.24 9.9 10.2 0.015 13.9 3.2 1.6 1 1 1 2 2 2 0 Spc7 kinetochore protein BLOC1_2 PF10046.4 KOO29159.1 - 0.25 11.4 3.4 0.63 10.2 0.3 2.7 2 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HALZ PF02183.13 KOO29159.1 - 0.31 10.7 1.8 23 4.7 0.0 3.5 4 0 0 4 4 4 0 Homeobox associated leucine zipper Syntaxin-6_N PF09177.6 KOO29159.1 - 0.39 11.1 5.5 0.76 10.2 0.4 3.1 2 1 1 3 3 3 0 Syntaxin 6, N-terminal GAS PF13851.1 KOO29159.1 - 0.55 9.4 12.8 0.073 12.2 5.5 1.8 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding AAA_13 PF13166.1 KOO29159.1 - 3.6 5.9 10.3 6.1 5.1 7.1 1.3 1 0 0 1 1 1 0 AAA domain EF-hand_7 PF13499.1 KOO29160.1 - 2e-15 56.6 0.0 3.1e-05 24.0 0.0 2.3 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO29160.1 - 1.7e-14 51.9 0.3 2.2e-06 26.5 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO29160.1 - 2.6e-13 48.6 0.4 6.8e-06 25.1 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO29160.1 - 7.1e-13 47.2 0.0 3.1e-05 23.4 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO29160.1 - 1.4e-09 37.4 0.5 0.0011 18.4 0.2 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.1 KOO29160.1 - 0.05 13.5 0.0 0.11 12.4 0.0 1.6 1 1 0 1 1 1 0 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO29160.1 - 0.065 13.2 0.0 0.19 11.7 0.0 1.9 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region p25-alpha PF05517.7 KOO29160.1 - 0.14 12.4 0.2 0.28 11.4 0.1 1.6 1 1 1 2 2 2 0 p25-alpha Sec1 PF00995.18 KOO29161.1 - 4.8e-119 398.5 0.0 5.5e-119 398.3 0.0 1.0 1 0 0 1 1 1 1 Sec1 family DUF3749 PF12568.3 KOO29161.1 - 0.11 12.0 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Ion_trans PF00520.26 KOO29162.1 - 1.1e-12 47.6 0.3 1.8e-12 46.9 0.2 1.3 1 0 0 1 1 1 1 Ion transport protein YqhR PF11085.3 KOO29162.1 - 0.068 12.6 3.5 0.085 12.3 1.0 2.0 2 0 0 2 2 2 0 Conserved membrane protein YqhR Pkinase PF00069.20 KOO29163.1 - 1.5e-54 184.9 0.0 2.5e-54 184.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29163.1 - 6.7e-28 97.4 0.0 1.1e-27 96.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Formyl_trans_N PF00551.14 KOO29163.1 - 0.04 13.4 0.0 0.13 11.8 0.0 1.8 1 0 0 1 1 1 0 Formyl transferase PI3K_C2 PF00792.19 KOO29164.1 - 0.00018 21.3 0.0 0.15 11.8 0.0 4.0 4 0 0 4 4 4 1 Phosphoinositide 3-kinase C2 zf-C2H2_jaz PF12171.3 KOO29164.1 - 0.25 11.5 0.1 0.52 10.5 0.1 1.4 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 KOO29164.1 - 0.28 11.5 0.5 0.76 10.2 0.3 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type PDZ PF00595.19 KOO29165.1 - 0.00067 19.7 0.0 0.0019 18.3 0.0 1.7 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) Far-17a_AIG1 PF04750.9 KOO29166.1 - 0.00091 18.4 6.2 0.0017 17.5 4.3 1.4 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein TIG PF01833.19 KOO29167.1 - 2.1e-10 40.4 11.8 0.00029 20.7 1.2 5.9 5 1 0 5 5 5 3 IPT/TIG domain CBM_X2 PF03442.9 KOO29167.1 - 0.053 13.3 0.4 0.11 12.2 0.0 1.7 2 0 0 2 2 2 0 Carbohydrate binding domain X2 DnaJ PF00226.26 KOO29168.1 - 1.5e-11 43.8 3.2 2e-11 43.4 1.2 2.1 2 0 0 2 2 2 1 DnaJ domain Chromo PF00385.19 KOO29168.1 - 2.2e-07 30.4 0.1 5e-07 29.2 0.1 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DEK_C PF08766.6 KOO29168.1 - 2.7e-07 30.2 1.5 7.6e-07 28.8 0.0 2.3 2 0 0 2 2 2 1 DEK C terminal domain ABC1 PF03109.11 KOO29169.1 - 2.2e-22 79.2 0.0 4.7e-22 78.1 0.0 1.6 1 0 0 1 1 1 1 ABC1 family SCP2 PF02036.12 KOO29169.1 - 2.4e-09 37.3 0.0 6.2e-09 36.0 0.0 1.7 1 0 0 1 1 1 1 SCP-2 sterol transfer family Beta-lactamase PF00144.19 KOO29169.1 - 1.6e-05 24.1 0.1 4.7e-05 22.5 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase PX PF00787.19 KOO29169.1 - 0.00019 21.1 0.0 0.00044 20.0 0.0 1.5 1 0 0 1 1 1 1 PX domain Pkinase PF00069.20 KOO29169.1 - 0.00038 19.6 0.0 0.00062 18.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Alkyl_sulf_C PF14864.1 KOO29169.1 - 0.077 12.9 0.0 0.28 11.1 0.0 1.9 2 0 0 2 2 2 0 Alkyl sulfatase C-terminal Rep-A_N PF04057.7 KOO29170.1 - 6.5e-09 35.4 0.0 2e-08 33.9 0.0 1.8 1 1 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.20 KOO29170.1 - 0.0058 16.4 0.0 0.15 11.9 0.0 2.4 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain Chromo PF00385.19 KOO29171.1 - 0.017 14.7 0.2 0.032 13.9 0.1 1.5 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain Methyltransf_21 PF05050.7 KOO29172.1 - 1.8e-06 28.0 0.0 2.1e-06 27.7 0.0 1.0 1 0 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_22 PF13383.1 KOO29172.1 - 0.00014 21.5 0.2 0.00015 21.4 0.1 1.1 1 0 0 1 1 1 1 Methyltransferase domain DUF4320 PF14208.1 KOO29172.1 - 0.11 12.4 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4320) adh_short PF00106.20 KOO29173.1 - 0.0034 17.2 0.0 0.013 15.4 0.0 1.8 1 1 1 2 2 2 1 short chain dehydrogenase Kinesin PF00225.18 KOO29174.1 - 8.6e-82 274.5 0.1 9.4e-82 274.3 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain AAA_10 PF12846.2 KOO29174.1 - 0.0085 15.5 0.0 0.012 15.1 0.0 1.2 1 0 0 1 1 1 1 AAA-like domain PIF1 PF05970.9 KOO29174.1 - 0.062 12.2 0.4 0.11 11.3 0.3 1.3 1 0 0 1 1 1 0 PIF1-like helicase AAA_22 PF13401.1 KOO29174.1 - 0.091 12.8 0.1 0.25 11.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain Syntaxin PF00804.20 KOO29175.1 - 0.016 15.3 2.7 0.016 15.3 1.8 1.9 2 0 0 2 2 2 0 Syntaxin SlyX PF04102.7 KOO29175.1 - 0.072 13.4 3.5 2.7 8.4 0.4 3.4 3 0 0 3 3 3 0 SlyX DUF2353 PF09789.4 KOO29175.1 - 0.082 12.1 6.4 0.14 11.4 4.5 1.4 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) AKNA PF12443.3 KOO29175.1 - 0.97 9.4 4.7 2.8 8.0 2.2 2.2 1 1 1 2 2 2 0 AT-hook-containing transcription factor Occludin_ELL PF07303.8 KOO29175.1 - 1.2 9.9 7.3 3.7 8.3 0.4 2.5 3 0 0 3 3 3 0 Occludin homology domain Seryl_tRNA_N PF02403.17 KOO29175.1 - 2.3 8.2 16.9 1.6 8.7 8.2 2.9 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Spc42p PF11544.3 KOO29175.1 - 4 7.4 10.5 1.2 9.1 0.4 3.4 3 1 0 3 3 3 0 Spindle pole body component Spc42p DUF4618 PF15397.1 KOO29175.1 - 4.1 6.6 9.9 3.3 6.9 0.6 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4618) Spc7 PF08317.6 KOO29175.1 - 4.2 5.9 12.9 1.3 7.6 1.2 2.9 2 1 1 3 3 3 0 Spc7 kinetochore protein DUF2630 PF10944.3 KOO29175.1 - 9 6.4 12.5 0.21 11.7 1.3 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2630) Arm PF00514.18 KOO29176.1 - 6.9e-28 95.4 10.2 7.3e-07 28.7 0.0 5.8 6 0 0 6 6 6 4 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO29176.1 - 1e-05 25.7 7.3 0.0072 16.5 0.2 3.4 3 1 1 4 4 4 2 HEAT repeats Arm_2 PF04826.8 KOO29176.1 - 0.0015 17.7 0.0 0.4 9.7 0.0 2.5 1 1 1 2 2 2 2 Armadillo-like HEAT_EZ PF13513.1 KOO29176.1 - 0.01 16.2 7.4 1.9 9.0 0.1 5.0 3 1 1 4 4 4 0 HEAT-like repeat adh_short PF00106.20 KOO29177.1 - 9e-13 48.4 0.0 1.6e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOO29177.1 - 0.0042 16.7 0.0 0.0066 16.1 0.0 1.3 1 0 0 1 1 1 1 KR domain Thioredoxin_6 PF13848.1 KOO29178.1 - 0.00078 19.2 0.0 0.00098 18.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin PF00085.15 KOO29178.1 - 0.076 12.7 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin FA_desaturase PF00487.19 KOO29180.1 - 2.8e-29 102.3 29.5 5.7e-29 101.3 20.4 1.5 1 1 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.23 KOO29180.1 - 7.2e-22 76.9 0.0 1.9e-21 75.6 0.0 1.8 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Melibiase PF02065.13 KOO29181.1 - 3.3e-17 62.2 0.0 9.3e-14 50.9 0.0 2.1 2 0 0 2 2 2 2 Melibiase DUF3459 PF11941.3 KOO29181.1 - 0.12 12.4 1.0 4.1 7.5 0.0 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF3459) Pirin PF02678.11 KOO29182.1 - 4.4e-30 103.7 1.2 4.6e-30 103.6 0.2 1.5 2 0 0 2 2 2 1 Pirin Pirin_C PF05726.8 KOO29182.1 - 1.4e-22 79.6 0.0 2.6e-22 78.8 0.0 1.4 1 0 0 1 1 1 1 Pirin C-terminal cupin domain Ion_trans PF00520.26 KOO29183.1 - 4.3e-25 88.1 9.9 1.1e-24 86.8 6.9 1.7 1 0 0 1 1 1 1 Ion transport protein MFS_1 PF07690.11 KOO29183.1 - 3.3e-14 52.3 37.0 3.3e-14 52.3 25.7 3.0 2 2 2 4 4 4 2 Major Facilitator Superfamily PKD_channel PF08016.7 KOO29183.1 - 0.00067 18.1 5.2 0.00067 18.1 3.6 2.3 2 1 0 2 2 2 1 Polycystin cation channel Nucleotid_trans PF03407.11 KOO29184.1 - 7.4e-10 38.9 0.0 1.2e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase DUF1680 PF07944.7 KOO29185.1 - 5.5e-20 71.1 0.0 7.6e-20 70.6 0.0 1.2 1 0 0 1 1 1 1 Putative glycosyl hydrolase of unknown function (DUF1680) Peptidase_M14 PF00246.19 KOO29186.1 - 6.1e-27 94.9 0.0 1.1e-26 94.1 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase Neurochondrin PF05536.6 KOO29186.1 - 0.034 12.4 1.5 0.11 10.7 0.1 1.9 1 1 1 2 2 2 0 Neurochondrin Arm PF00514.18 KOO29186.1 - 0.49 10.2 7.9 0.42 10.4 0.1 3.3 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat VKOR PF07884.9 KOO29187.1 - 4.6e-21 75.1 8.1 9.5e-21 74.0 5.6 1.5 1 0 0 1 1 1 1 Vitamin K epoxide reductase family Thioredoxin PF00085.15 KOO29187.1 - 0.14 11.8 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin UIM PF02809.15 KOO29188.1 - 0.12 12.0 1.5 3.1 7.6 0.0 2.6 2 0 0 2 2 2 0 Ubiquitin interaction motif ADP_ribosyl_GH PF03747.9 KOO29189.1 - 1.9 8.1 5.5 0.39 10.4 0.3 1.9 1 1 1 2 2 2 0 ADP-ribosylglycohydrolase HET PF06985.6 KOO29190.1 - 0.039 14.1 0.1 0.35 11.0 0.0 2.3 3 0 0 3 3 3 0 Heterokaryon incompatibility protein (HET) DUF1764 PF08576.5 KOO29193.1 - 6.4e-12 46.1 6.1 6.4e-12 46.1 4.2 3.0 1 1 1 2 2 2 1 Eukaryotic protein of unknown function (DUF1764) NAM-associated PF14303.1 KOO29193.1 - 0.48 10.7 7.7 0.69 10.2 5.3 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain WW PF00397.21 KOO29194.1 - 0.00011 21.9 0.6 0.11 12.4 0.0 3.2 3 0 0 3 3 3 2 WW domain Bestrophin PF01062.16 KOO29194.1 - 0.13 11.1 4.6 6.3 5.6 0.0 2.4 2 0 0 2 2 2 0 Bestrophin, RFP-TM, chloride channel Cupin_8 PF13621.1 KOO29195.1 - 4.5e-33 114.7 0.1 6.9e-33 114.1 0.1 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 KOO29195.1 - 9.3e-07 28.3 0.7 3.3e-06 26.5 0.5 2.0 1 1 0 1 1 1 1 Cupin superfamily protein Cupin_6 PF12852.2 KOO29195.1 - 0.024 14.2 0.0 0.41 10.2 0.0 2.2 2 0 0 2 2 2 0 Cupin Cupin_2 PF07883.6 KOO29195.1 - 0.029 13.8 0.0 0.069 12.6 0.0 1.6 1 0 0 1 1 1 0 Cupin domain Cupin_1 PF00190.17 KOO29195.1 - 0.093 12.1 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Cupin KH_1 PF00013.24 KOO29197.1 - 0.00016 21.2 0.0 0.00029 20.3 0.0 1.4 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 KOO29197.1 - 0.15 11.7 0.0 0.37 10.5 0.0 1.6 1 0 0 1 1 1 0 KH domain nlz1 PF12402.3 KOO29197.1 - 0.2 12.0 14.8 45 4.4 0.3 5.9 2 1 4 6 6 6 0 NocA-like zinc-finger protein 1 ADH_zinc_N_2 PF13602.1 KOO29198.1 - 4.1e-14 53.5 0.3 2.1e-13 51.2 0.0 2.3 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 KOO29198.1 - 6.6e-09 35.4 0.1 1.5e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOO29198.1 - 9.7e-07 28.5 0.0 5.3e-06 26.1 0.0 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Eno-Rase_NADH_b PF12242.3 KOO29198.1 - 0.061 13.1 0.6 0.45 10.3 0.8 2.2 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase RNA_pol_A_bac PF01000.21 KOO29199.1 - 6.8e-29 100.2 0.0 1.9e-28 98.8 0.0 1.8 1 1 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain MORN PF02493.15 KOO29199.1 - 1.1e-16 59.4 6.8 1.1e-05 24.8 0.2 3.6 3 0 0 3 3 3 3 MORN repeat RNA_pol_L PF01193.19 KOO29199.1 - 2.8e-15 55.2 0.1 6.9e-15 53.9 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb3/Rpb11 dimerisation domain NAD_binding_8 PF13450.1 KOO29201.1 - 5.7e-07 29.4 0.5 1.5e-06 28.0 0.4 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 KOO29201.1 - 2.6e-05 23.4 5.9 0.037 13.1 0.8 2.9 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase Radical_SAM PF04055.16 KOO29202.1 - 5.8e-17 62.3 0.0 1.1e-16 61.4 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.1 KOO29202.1 - 1.1e-06 28.8 0.0 2.3e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.1 KOO29202.1 - 3.5e-06 27.0 0.0 9.3e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain Anthrax_toxA PF03497.11 KOO29202.1 - 0.083 12.7 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Anthrax toxin LF subunit SelR PF01641.13 KOO29203.1 - 0.00021 20.9 0.7 0.0011 18.6 0.5 2.0 1 1 0 1 1 1 1 SelR domain HSDR_N PF04313.9 KOO29204.1 - 0.043 13.5 0.9 0.054 13.2 0.6 1.1 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) Ino80_Iec3 PF14612.1 KOO29204.1 - 0.067 13.2 2.4 0.082 12.9 1.7 1.0 1 0 0 1 1 1 0 IEC3 subunit of the Ino80 complex, chromatin re-modelling FUSC PF04632.7 KOO29204.1 - 0.17 10.2 21.1 0.18 10.1 14.6 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family GAS PF13851.1 KOO29204.1 - 0.19 10.9 2.1 0.26 10.4 1.5 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF4404 PF14357.1 KOO29204.1 - 0.47 10.8 0.1 0.47 10.8 0.1 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4404) CbiQ PF02361.11 KOO29205.1 - 0.27 10.7 3.6 1.9 8.0 0.0 2.4 2 0 0 2 2 2 0 Cobalt transport protein DUF4515 PF14988.1 KOO29206.1 - 2.6e-10 40.2 38.2 2.6e-10 40.2 26.5 2.9 2 1 1 3 3 3 1 Domain of unknown function (DUF4515) DcpS_C PF11969.3 KOO29206.1 - 0.05 13.8 0.2 0.05 13.8 0.2 2.5 4 0 0 4 4 4 0 Scavenger mRNA decapping enzyme C-term binding Selenoprotein_S PF06936.6 KOO29207.1 - 0.043 13.3 0.6 0.054 13.0 0.4 1.1 1 0 0 1 1 1 0 Selenoprotein S (SelS) Pkinase PF00069.20 KOO29208.1 - 8.7e-59 198.7 0.0 2.4e-53 180.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29208.1 - 9.5e-56 188.7 0.0 4.9e-55 186.3 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Arf PF00025.16 KOO29208.1 - 1e-42 145.3 0.0 2.6e-42 144.0 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 KOO29208.1 - 2.2e-08 33.5 0.0 3.7e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 KOO29208.1 - 9.4e-08 32.0 0.0 1.6e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.15 KOO29208.1 - 2.9e-07 29.5 0.1 0.0005 18.8 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Miro PF08477.8 KOO29208.1 - 2.8e-05 24.5 0.0 4.7e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Ras PF00071.17 KOO29208.1 - 6.4e-05 22.3 0.0 0.0001 21.6 0.0 1.3 1 0 0 1 1 1 1 Ras family SH3_1 PF00018.23 KOO29208.1 - 0.00025 20.3 0.0 0.00049 19.4 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 KOO29208.1 - 0.00091 18.6 0.0 0.002 17.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Gtr1_RagA PF04670.7 KOO29208.1 - 0.0022 17.1 0.0 0.0033 16.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SH3_9 PF14604.1 KOO29208.1 - 0.0032 17.0 0.9 0.021 14.3 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain AAA_33 PF13671.1 KOO29208.1 - 0.008 16.0 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain GTP_EFTU PF00009.22 KOO29208.1 - 0.014 14.7 0.0 0.33 10.3 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Kdo PF06293.9 KOO29208.1 - 0.02 13.9 0.1 4.4 6.3 0.1 2.4 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family ATP_bind_1 PF03029.12 KOO29208.1 - 0.4 10.1 0.0 1.5 8.3 0.0 1.9 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein Methyltransf_18 PF12847.2 KOO29209.1 - 8.1e-11 42.4 1.1 3.2e-07 30.8 0.0 2.7 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_11 PF08241.7 KOO29209.1 - 6.7e-09 36.1 0.1 7e-07 29.6 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO29209.1 - 8.2e-09 35.3 0.0 2.3e-08 33.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO29209.1 - 9e-09 35.6 0.3 2.5e-08 34.1 0.2 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO29209.1 - 9.6e-09 35.6 0.0 1.5e-07 31.8 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO29209.1 - 3.1e-07 30.4 0.1 7.7e-07 29.1 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO29209.1 - 6.4e-07 29.0 0.4 8.5e-05 22.1 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_28 PF02636.12 KOO29209.1 - 0.022 14.1 0.1 1.2 8.4 0.0 2.7 2 1 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase MTS PF05175.9 KOO29209.1 - 0.029 13.7 0.2 2.9 7.2 0.1 2.4 2 1 0 2 2 2 0 Methyltransferase small domain SecE PF00584.15 KOO29210.1 - 6.2e-14 51.3 0.2 7.4e-14 51.0 0.2 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex TUDOR PF00567.19 KOO29211.1 - 0.12 12.1 0.0 1.1 9.1 0.0 2.2 1 1 1 2 2 2 0 Tudor domain VPS9 PF02204.13 KOO29212.1 - 3.9e-14 52.5 0.2 6.8e-14 51.7 0.1 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain 2OG-FeII_Oxy_3 PF13640.1 KOO29213.1 - 2.3e-09 37.6 0.0 1.6e-08 34.9 0.0 2.2 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO29213.1 - 3.9e-08 33.4 0.0 8.7e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO29213.1 - 0.00042 19.8 0.0 0.00093 18.7 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ShK PF01549.19 KOO29213.1 - 0.041 14.2 3.7 0.073 13.4 2.6 1.4 1 0 0 1 1 1 0 ShK domain-like CBFD_NFYB_HMF PF00808.18 KOO29214.1 - 7.2e-07 29.1 0.0 1.1e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF2587 PF10759.4 KOO29214.1 - 0.015 14.6 0.5 0.022 14.1 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2587) Mg_trans_NIPA PF05653.9 KOO29215.1 - 4.6e-19 68.4 6.8 6e-19 68.1 4.7 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA Multi_Drug_Res PF00893.14 KOO29215.1 - 1.3 9.5 7.4 0.28 11.6 0.5 2.8 2 2 0 2 2 2 0 Small Multidrug Resistance protein MatE PF01554.13 KOO29216.1 - 2.4e-11 43.5 7.8 2.4e-11 43.5 5.4 3.7 5 1 0 5 5 5 2 MatE FKBP_C PF00254.23 KOO29216.1 - 2.6e-07 30.5 0.0 4.5e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF677 PF05055.7 KOO29216.1 - 4.3 5.9 3.8 8.6 4.9 2.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF677) DUF221 PF02714.10 KOO29217.1 - 8.4e-13 47.8 2.0 2.2e-05 23.4 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function DUF221 Filamin PF00630.14 KOO29218.1 - 9e-06 26.1 0.1 2.7e-05 24.6 0.0 1.7 2 0 0 2 2 2 1 Filamin/ABP280 repeat Spc7 PF08317.6 KOO29218.1 - 0.059 12.0 0.6 0.074 11.7 0.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Acyl-CoA_dh_2 PF08028.6 KOO29218.1 - 4.8 7.4 18.2 0.68 10.1 8.9 2.0 1 1 1 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain ALIX_LYPXL_bnd PF13949.1 KOO29219.1 - 0.037 12.9 10.1 0.054 12.4 7.0 1.3 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV Tho2 PF11262.3 KOO29219.1 - 0.06 12.3 4.5 0.073 12.1 2.9 1.3 1 1 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Syntaxin PF00804.20 KOO29219.1 - 0.062 13.4 3.2 0.11 12.6 1.8 1.8 1 1 0 1 1 1 0 Syntaxin GAS PF13851.1 KOO29219.1 - 0.44 9.7 11.4 0.65 9.1 7.9 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Phage_cap_E PF03864.10 KOO29219.1 - 0.45 9.3 2.8 0.49 9.2 0.4 2.0 2 0 0 2 2 2 0 Phage major capsid protein E APG6 PF04111.7 KOO29219.1 - 0.63 9.0 12.6 1.2 8.1 8.7 1.4 1 1 0 1 1 1 0 Autophagy protein Apg6 IncA PF04156.9 KOO29219.1 - 0.66 9.5 15.8 0.14 11.7 7.8 1.7 1 1 1 2 2 2 0 IncA protein Ax_dynein_light PF10211.4 KOO29219.1 - 0.67 9.7 9.1 0.93 9.3 6.0 1.4 1 1 0 1 1 1 0 Axonemal dynein light chain TMPIT PF07851.8 KOO29219.1 - 1 8.3 3.8 2.1 7.3 1.9 1.8 2 0 0 2 2 2 0 TMPIT-like protein Nnf1 PF03980.9 KOO29219.1 - 2.7 7.9 10.3 2.3 8.2 0.6 2.4 2 1 0 2 2 2 0 Nnf1 YlqD PF11068.3 KOO29219.1 - 3.6 7.6 11.9 1.7 8.6 4.7 2.1 1 1 1 2 2 2 0 YlqD protein DUF342 PF03961.8 KOO29219.1 - 4.9 5.4 11.5 1.5 7.1 5.6 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF342) AAA_23 PF13476.1 KOO29219.1 - 7 6.9 9.2 9.7 6.4 6.4 1.3 1 0 0 1 1 1 0 AAA domain Muted PF14942.1 KOO29220.1 - 0.12 12.2 5.8 0.05 13.4 0.7 2.1 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein DNA_pol_viral_N PF00242.12 KOO29220.1 - 0.67 8.9 3.4 0.84 8.6 2.4 1.2 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain V-SNARE_C PF12352.3 KOO29221.1 - 4e-11 42.8 0.7 1.9e-10 40.6 0.1 2.3 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus COMP PF11598.3 KOO29221.1 - 0.098 12.7 0.6 13 5.9 0.1 2.6 2 0 0 2 2 2 0 Cartilage oligomeric matrix protein Mid2 PF04478.7 KOO29221.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor DUF4201 PF13870.1 KOO29221.1 - 1.4 8.2 6.6 1.7 8.0 3.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) AP2 PF00847.15 KOO29222.1 - 2.2e-07 30.9 10.0 0.0088 16.1 0.1 4.7 3 1 0 3 3 3 2 AP2 domain IF3_N PF05198.11 KOO29222.1 - 0.25 11.2 5.1 7.4 6.5 0.0 3.7 4 0 0 4 4 4 0 Translation initiation factor IF-3, N-terminal domain Atg14 PF10186.4 KOO29223.1 - 0.11 11.4 8.7 0.71 8.7 0.5 2.3 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 HSNSD PF12062.3 KOO29224.1 - 0.0052 15.2 0.0 0.0074 14.7 0.0 1.1 1 0 0 1 1 1 1 heparan sulfate-N-deacetylase GSHPx PF00255.14 KOO29225.1 - 6.2e-22 77.0 0.0 7.9e-22 76.6 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase DUF4174 PF13778.1 KOO29225.1 - 0.023 14.7 0.0 0.027 14.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) DUF2638 PF10937.3 KOO29226.1 - 4.6e-07 30.8 0.0 1e-06 29.7 0.0 1.5 1 1 1 2 2 2 1 Protein of unknown function (DUF2638) Biotin_lipoyl PF00364.17 KOO29226.1 - 8.9e-07 28.4 0.2 1.3e-06 27.9 0.2 1.2 1 0 0 1 1 1 1 Biotin-requiring enzyme PYNP_C PF07831.8 KOO29226.1 - 0.1 12.0 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Pyrimidine nucleoside phosphorylase C-terminal domain Bestrophin PF01062.16 KOO29227.1 - 5.5e-14 51.7 0.2 5.5e-14 51.7 0.1 1.7 2 0 0 2 2 2 1 Bestrophin, RFP-TM, chloride channel MOZART1 PF12554.3 KOO29227.1 - 0.05 13.0 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated HSBP1 PF06825.7 KOO29227.1 - 0.11 12.0 0.4 2.5 7.7 0.0 2.5 2 0 0 2 2 2 0 Heat shock factor binding protein 1 ATP-synt_C PF00137.16 KOO29228.1 - 8.5e-28 96.0 42.4 5.5e-17 61.4 8.4 3.2 3 0 0 3 3 3 2 ATP synthase subunit C Peptidase_C97 PF05903.9 KOO29228.1 - 3.8e-15 55.9 0.0 6.3e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain YpjP PF14005.1 KOO29229.1 - 0.022 14.5 0.3 0.25 11.0 0.0 2.2 2 0 0 2 2 2 0 YpjP-like protein ATC_hydrolase PF14196.1 KOO29229.1 - 0.061 13.7 0.1 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 L-2-amino-thiazoline-4-carboxylic acid hydrolase YusW PF14039.1 KOO29230.1 - 0.032 14.5 1.5 0.11 12.7 1.1 2.0 1 1 0 1 1 1 0 YusW-like protein PAT1 PF09770.4 KOO29230.1 - 7.6 4.6 21.1 9.4 4.3 14.6 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Tubulin PF00091.20 KOO29231.1 - 5.6e-63 212.6 0.0 8.3e-63 212.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 KOO29231.1 - 2.9e-47 159.8 0.1 4.4e-47 159.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.1 KOO29231.1 - 0.017 14.6 0.0 0.053 12.9 0.0 1.8 2 0 0 2 2 2 0 Tubulin domain Arm PF00514.18 KOO29232.1 - 3.1e-11 42.6 20.5 7.9e-05 22.3 0.2 6.8 8 0 0 8 8 8 3 Armadillo/beta-catenin-like repeat EF-hand_1 PF00036.27 KOO29232.1 - 3.8e-10 38.3 0.8 0.0017 17.5 0.0 3.5 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO29232.1 - 4.3e-10 38.6 0.4 0.0007 19.2 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO29232.1 - 8e-09 35.5 0.6 2.6e-07 30.6 0.2 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO29232.1 - 1e-06 28.2 0.3 0.0004 19.9 0.1 3.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO29232.1 - 6.8e-05 22.0 1.8 0.0077 15.5 0.0 3.0 3 0 0 3 3 3 1 EF hand EF-hand_10 PF14788.1 KOO29232.1 - 0.0029 17.2 0.2 0.75 9.5 0.0 3.3 3 0 0 3 3 3 1 EF hand Atx10homo_assoc PF09759.4 KOO29232.1 - 0.024 14.3 0.0 3.1 7.5 0.0 3.4 3 1 1 4 4 4 0 Spinocerebellar ataxia type 10 protein domain NusG PF02357.14 KOO29234.1 - 1.2e-10 41.4 0.2 2e-10 40.7 0.1 1.5 1 1 0 1 1 1 1 Transcription termination factor nusG Het-C PF07217.6 KOO29235.1 - 0.003 15.8 0.1 0.0051 15.0 0.1 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C IFT57 PF10498.4 KOO29235.1 - 1.6 7.4 6.7 0.17 10.5 0.4 2.0 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Methyltransf_26 PF13659.1 KOO29236.1 - 2.6e-17 62.9 0.8 5.4e-17 61.9 0.2 1.7 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 KOO29236.1 - 6.5e-13 48.3 0.0 9.9e-13 47.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.1 KOO29236.1 - 2.9e-12 46.4 0.0 4e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO29236.1 - 9.4e-10 39.0 0.1 2.6e-09 37.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO29236.1 - 1.2e-08 35.3 0.0 2.5e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 KOO29236.1 - 1.8e-06 27.3 0.0 2.5e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.1 KOO29236.1 - 3.4e-06 27.3 0.0 1.1e-05 25.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO29236.1 - 9e-06 26.0 0.0 2.1e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 KOO29236.1 - 2.6e-05 23.8 0.0 4.6e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_23 PF13489.1 KOO29236.1 - 4.2e-05 23.3 0.0 6.8e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.10 KOO29236.1 - 9.1e-05 21.9 0.0 0.00013 21.3 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_32 PF13679.1 KOO29236.1 - 0.0031 17.1 0.0 0.0054 16.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 KOO29236.1 - 0.013 15.0 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase PCMT PF01135.14 KOO29236.1 - 0.027 14.0 0.0 0.04 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Eco57I PF07669.6 KOO29236.1 - 0.071 13.4 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 Eco57I restriction-modification methylase Methyltransf_4 PF02390.12 KOO29236.1 - 0.097 11.7 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase DUF2997 PF11211.3 KOO29237.1 - 3.3e-17 61.5 0.2 6.2e-17 60.7 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2997) Ion_trans PF00520.26 KOO29238.1 - 1.1e-29 103.1 14.6 1.6e-29 102.6 10.1 1.2 1 0 0 1 1 1 1 Ion transport protein EF-hand_1 PF00036.27 KOO29238.1 - 3.3e-06 26.0 0.1 1.2e-05 24.2 0.1 2.1 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO29238.1 - 8.8e-06 25.1 0.0 3.3e-05 23.3 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain PKD_channel PF08016.7 KOO29238.1 - 3.9e-05 22.2 10.7 0.0065 14.9 1.9 2.2 2 0 0 2 2 2 2 Polycystin cation channel EF-hand_5 PF13202.1 KOO29238.1 - 0.00068 18.8 0.0 0.0017 17.5 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO29238.1 - 0.0012 18.9 0.0 0.0049 16.9 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair Ni_hydr_CYTB PF01292.15 KOO29238.1 - 0.25 10.7 0.0 0.25 10.7 0.0 2.1 2 1 0 2 2 2 0 Prokaryotic cytochrome b561 COG5 PF10392.4 KOO29240.1 - 1.6e-12 47.5 1.0 3.4e-12 46.4 0.7 1.5 1 0 0 1 1 1 1 Golgi transport complex subunit 5 DUF489 PF04356.7 KOO29240.1 - 0.01 15.4 0.1 0.02 14.5 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF489) Sec8_exocyst PF04048.9 KOO29240.1 - 0.022 14.3 0.1 0.079 12.5 0.0 1.9 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain U-box PF04564.10 KOO29241.1 - 4.4e-34 116.2 0.1 1.1e-15 57.2 0.0 2.4 1 1 1 2 2 2 2 U-box domain TPR_11 PF13414.1 KOO29241.1 - 8.4e-19 66.9 25.8 0.0035 16.9 0.0 10.1 9 1 2 11 11 11 6 TPR repeat TPR_2 PF07719.12 KOO29241.1 - 3.1e-12 45.3 10.9 0.071 13.0 0.0 10.2 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO29241.1 - 5e-12 44.8 0.4 0.055 13.1 0.0 8.0 10 0 0 10 10 10 3 Tetratricopeptide repeat zf-Nse PF11789.3 KOO29241.1 - 4.6e-08 32.4 0.0 0.012 15.0 0.0 2.5 2 0 0 2 2 2 2 Zinc-finger of the MIZ type in Nse subunit TPR_14 PF13428.1 KOO29241.1 - 8.1e-07 29.1 51.9 0.0073 16.8 1.1 12.0 11 1 1 13 13 11 4 Tetratricopeptide repeat zf-RING_UBOX PF13445.1 KOO29241.1 - 5.9e-06 25.8 0.1 0.17 11.6 0.0 2.9 3 0 0 3 3 3 2 RING-type zinc-finger TPR_16 PF13432.1 KOO29241.1 - 4.2e-05 24.0 53.3 0.064 13.9 1.3 12.0 10 1 4 14 14 14 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO29241.1 - 0.0065 16.5 10.4 33 5.0 0.0 8.0 10 0 0 10 10 8 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOO29241.1 - 0.017 14.8 0.0 4.9 7.1 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat zf-rbx1 PF12678.2 KOO29241.1 - 0.22 11.6 0.0 38 4.5 0.0 2.5 2 0 0 2 2 2 0 RING-H2 zinc finger LRR_6 PF13516.1 KOO29242.1 - 3e-06 26.7 5.5 0.7 10.1 0.0 8.2 9 0 0 9 9 9 1 Leucine Rich repeat LRR_1 PF00560.28 KOO29242.1 - 0.0012 18.6 5.4 33 5.0 0.0 7.3 8 2 0 8 8 8 1 Leucine Rich Repeat Ste50p-SAM PF09235.5 KOO29242.1 - 0.22 11.6 7.2 31 4.6 0.0 5.4 5 2 2 7 7 7 0 Ste50p, sterile alpha motif LRR_7 PF13504.1 KOO29242.1 - 0.71 10.3 22.2 5.5 7.6 0.0 9.8 11 0 0 11 11 11 0 Leucine rich repeat Epimerase PF01370.16 KOO29244.1 - 2.8e-67 226.6 0.1 3.8e-67 226.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 KOO29244.1 - 0.00011 21.1 0.0 0.00018 20.5 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase_Csub PF13950.1 KOO29244.1 - 0.00039 20.3 0.0 0.0012 18.7 0.0 1.8 2 0 0 2 2 2 1 UDP-glucose 4-epimerase C-term subunit NAD_binding_10 PF13460.1 KOO29244.1 - 0.028 14.4 0.0 0.08 12.9 0.0 1.7 1 0 0 1 1 1 0 NADH(P)-binding Polysacc_synt_2 PF02719.10 KOO29244.1 - 0.15 10.9 0.0 0.36 9.6 0.0 1.6 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein SPRY PF00622.23 KOO29246.1 - 2.1e-07 31.0 0.1 1.4e-06 28.3 0.0 2.0 1 1 0 1 1 1 1 SPRY domain Peptidase_C2 PF00648.16 KOO29247.1 - 1.5e-54 185.0 0.0 3.9e-54 183.6 0.0 1.6 2 0 0 2 2 2 1 Calpain family cysteine protease zf-GRF PF06839.7 KOO29247.1 - 1e-11 44.5 1.7 1.9e-11 43.6 1.2 1.5 1 0 0 1 1 1 1 GRF zinc finger LRR_6 PF13516.1 KOO29249.1 - 1.6e-09 36.8 2.1 0.00042 20.0 0.2 3.8 4 0 0 4 4 4 2 Leucine Rich repeat LRR_4 PF12799.2 KOO29249.1 - 0.0017 17.9 0.1 0.053 13.1 0.0 2.2 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) PK PF00224.16 KOO29250.1 - 7.6e-121 402.9 1.9 1e-120 402.5 1.3 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.11 KOO29250.1 - 4.9e-18 64.7 0.0 2.6e-17 62.4 0.0 2.2 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.9 KOO29250.1 - 0.0059 15.5 1.1 0.02 13.7 0.8 1.8 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family CytB6-F_Fe-S PF08802.5 KOO29251.1 - 0.0031 17.4 2.8 9.3 6.3 0.0 5.0 5 0 0 5 5 5 1 Cytochrome B6-F complex Fe-S subunit Caudo_TAP PF02413.12 KOO29251.1 - 0.028 14.5 0.2 0.028 14.5 0.2 7.4 7 1 1 8 8 8 0 Caudovirales tail fibre assembly protein DUF4572 PF15139.1 KOO29251.1 - 0.06 13.1 1.5 0.21 11.3 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4572) DnaG_DnaB_bind PF08278.6 KOO29251.1 - 1 9.6 60.2 1 9.6 0.5 9.4 6 3 3 9 9 9 0 DNA primase DnaG DnaB-binding LisH PF08513.6 KOO29252.1 - 2.2e-06 27.1 0.0 3.1e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 LisH z-alpha PF02295.12 KOO29252.1 - 0.031 14.0 0.0 0.034 13.9 0.0 1.2 1 0 0 1 1 1 0 Adenosine deaminase z-alpha domain SNARE_assoc PF09335.6 KOO29253.1 - 1.3e-05 25.4 3.2 1.3e-05 25.4 2.2 1.5 2 0 0 2 2 2 1 SNARE associated Golgi protein Pkinase PF00069.20 KOO29254.1 - 7.2e-55 185.9 0.0 8.8e-55 185.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29254.1 - 8.1e-27 93.9 0.0 1.1e-26 93.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO29254.1 - 0.003 16.5 0.0 0.0049 15.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like NAD_binding_2 PF03446.10 KOO29255.1 - 2.3e-36 125.0 1.1 4.3e-36 124.2 0.7 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 KOO29255.1 - 9.4e-23 80.5 3.0 1.9e-22 79.5 2.1 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.12 KOO29255.1 - 3.3e-08 33.8 0.0 7.4e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Ion_trans_2 PF07885.11 KOO29255.1 - 4.8e-07 29.3 0.7 4.8e-07 29.3 0.5 2.4 2 0 0 2 2 2 1 Ion channel Shikimate_DH PF01488.15 KOO29255.1 - 4e-05 23.7 0.0 7.3e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase SK_channel PF03530.9 KOO29255.1 - 0.0016 18.2 5.2 0.0031 17.3 2.1 2.5 2 1 0 2 2 2 1 Calcium-activated SK potassium channel PDZ PF00595.19 KOO29258.1 - 0.073 13.2 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) PVL_ORF50 PF07768.6 KOO29258.1 - 0.095 12.7 7.8 0.046 13.7 3.8 1.6 2 0 0 2 2 2 0 PVL ORF-50-like family Ndufs5 PF10200.4 KOO29259.1 - 0.0061 16.5 5.6 1.7 8.6 0.0 4.8 5 0 0 5 5 5 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa EF-hand_7 PF13499.1 KOO29259.1 - 0.24 11.5 2.8 14 5.8 0.0 5.5 6 0 0 6 6 6 0 EF-hand domain pair EF-hand_1 PF00036.27 KOO29259.1 - 1.4 8.4 13.9 95 2.6 0.1 7.7 8 0 0 8 8 8 0 EF hand Ion_trans_2 PF07885.11 KOO29260.1 - 7.5e-23 80.0 9.1 7.7e-14 51.1 0.9 2.2 2 0 0 2 2 2 2 Ion channel EF-hand_7 PF13499.1 KOO29260.1 - 0.0013 18.7 1.6 0.046 13.8 0.1 2.8 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO29260.1 - 0.0034 17.1 6.3 0.0047 16.7 0.1 3.0 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.27 KOO29260.1 - 0.016 14.5 11.0 0.046 13.0 0.2 3.5 3 0 0 3 3 3 0 EF hand Ion_trans PF00520.26 KOO29260.1 - 0.017 14.4 4.7 0.046 12.9 0.2 2.5 2 0 0 2 2 2 0 Ion transport protein EF-hand_5 PF13202.1 KOO29260.1 - 0.46 9.9 12.7 0.21 10.9 0.2 3.7 4 0 0 4 4 4 0 EF hand AAA_28 PF13521.1 KOO29261.1 - 2.2e-10 40.7 0.6 2.2e-09 37.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain DUF390 PF04094.9 KOO29261.1 - 0.013 13.5 8.8 0.017 13.1 6.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF390) Telomere_Sde2 PF13019.1 KOO29261.1 - 0.082 12.5 0.7 0.14 11.8 0.5 1.3 1 0 0 1 1 1 0 Telomere stability and silencing TTL PF03133.10 KOO29262.1 - 5.2e-62 209.4 0.0 6.7e-62 209.0 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATP-grasp_4 PF13535.1 KOO29262.1 - 0.0026 17.4 0.0 0.0044 16.7 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_YheCD PF14398.1 KOO29262.1 - 0.046 12.5 0.1 0.72 8.5 0.1 2.2 1 1 0 1 1 1 0 YheC/D like ATP-grasp TTL PF03133.10 KOO29263.1 - 4.5e-13 48.7 0.1 5.6e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 KOO29263.1 - 0.011 14.5 0.0 0.015 14.1 0.0 1.1 1 0 0 1 1 1 0 YheC/D like ATP-grasp Myosin_head PF00063.16 KOO29264.1 - 1e-176 589.0 1.8 2.3e-107 359.7 0.0 2.0 2 0 0 2 2 2 2 Myosin head (motor domain) AAA_22 PF13401.1 KOO29264.1 - 0.00039 20.5 0.0 0.0038 17.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 KOO29264.1 - 0.0094 15.0 0.1 0.023 13.7 0.1 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.1 KOO29264.1 - 0.032 14.2 0.0 0.1 12.5 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_19 PF13245.1 KOO29264.1 - 0.04 13.6 0.0 0.12 12.1 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain LRR_6 PF13516.1 KOO29265.1 - 0.00026 20.7 0.1 1.5 9.1 0.0 4.2 5 0 0 5 5 5 2 Leucine Rich repeat NACHT PF05729.7 KOO29265.1 - 0.016 14.8 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Methyltransf_21 PF05050.7 KOO29266.1 - 6.6e-13 48.9 0.0 1.1e-12 48.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain V-SNARE_C PF12352.3 KOO29267.1 - 1.5e-13 50.5 1.0 1.5e-13 50.5 0.7 2.8 2 1 1 3 3 3 2 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.10 KOO29267.1 - 3.5e-11 43.0 0.7 3.5e-11 43.0 0.5 2.3 2 1 0 3 3 3 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.8 KOO29267.1 - 4.3e-05 23.1 0.1 0.00016 21.2 0.0 1.9 1 1 0 1 1 1 1 Sec20 ApoO PF09769.4 KOO29267.1 - 0.00076 19.2 0.1 0.0013 18.4 0.1 1.4 1 0 0 1 1 1 1 Apolipoprotein O MscS_porin PF12795.2 KOO29267.1 - 0.0036 16.6 2.4 0.0055 16.0 1.7 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain MRP-S26 PF14943.1 KOO29267.1 - 0.038 13.5 4.2 0.057 12.9 2.9 1.2 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Mnd1 PF03962.10 KOO29267.1 - 0.044 13.4 2.3 0.073 12.7 1.6 1.4 1 0 0 1 1 1 0 Mnd1 family SF-assemblin PF06705.6 KOO29267.1 - 0.045 12.9 5.2 0.16 11.1 3.4 1.8 1 1 1 2 2 2 0 SF-assemblin/beta giardin CDC37_N PF03234.9 KOO29267.1 - 0.18 12.1 4.1 0.26 11.5 2.8 1.2 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding DUF4200 PF13863.1 KOO29267.1 - 1.1 9.2 8.8 6.5 6.7 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Adeno_PIX PF03955.9 KOO29267.1 - 7 7.2 6.8 8.2 6.9 1.4 2.5 1 1 2 3 3 3 0 Adenovirus hexon-associated protein (IX) PP-binding PF00550.20 KOO29268.1 - 1.7e-07 31.3 0.0 6.7e-07 29.4 0.0 2.1 2 0 0 2 2 2 1 Phosphopantetheine attachment site Methyltransf_26 PF13659.1 KOO29268.1 - 1.8e-05 24.7 0.3 1.8e-05 24.7 0.2 2.3 2 1 0 2 2 2 1 Methyltransferase domain MarR_2 PF12802.2 KOO29268.1 - 0.03 13.9 0.1 0.092 12.4 0.0 1.9 1 0 0 1 1 1 0 MarR family Methyltransf_32 PF13679.1 KOO29268.1 - 0.096 12.3 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain IncA PF04156.9 KOO29269.1 - 0.009 15.6 4.7 0.0096 15.5 3.3 1.1 1 0 0 1 1 1 1 IncA protein ADIP PF11559.3 KOO29269.1 - 0.13 12.1 8.9 0.14 12.0 6.2 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding HemX PF04375.9 KOO29269.1 - 0.17 10.4 10.2 0.19 10.2 7.1 1.0 1 0 0 1 1 1 0 HemX V_ATPase_I PF01496.14 KOO29269.1 - 0.38 8.5 2.6 0.41 8.4 1.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NBP1 PF08537.5 KOO29269.1 - 0.74 8.9 9.0 0.87 8.7 6.2 1.0 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 DUF3450 PF11932.3 KOO29269.1 - 0.97 8.6 8.8 1.2 8.3 6.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Borrelia_P83 PF05262.6 KOO29269.1 - 1 7.5 10.4 1.2 7.2 7.2 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Dsh_C PF12316.3 KOO29269.1 - 1.1 9.3 5.8 1.2 9.2 4.0 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal CorA PF01544.13 KOO29269.1 - 1.1 8.1 3.9 1.3 8.0 2.7 1.0 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein APG6 PF04111.7 KOO29269.1 - 1.5 7.8 6.2 1.6 7.6 4.3 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 Atg14 PF10186.4 KOO29269.1 - 1.6 7.6 8.2 2.1 7.2 5.7 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Phage_GPO PF05929.6 KOO29269.1 - 1.7 7.8 5.6 1.8 7.7 3.9 1.0 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase ARGLU PF15346.1 KOO29269.1 - 2.2 8.0 23.7 3.7 7.3 16.4 1.4 1 1 0 1 1 1 0 Arginine and glutamate-rich 1 OmpH PF03938.9 KOO29269.1 - 3.4 7.5 10.0 4.2 7.2 6.9 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF874 PF05917.6 KOO29269.1 - 3.7 6.2 6.7 4.2 6.1 4.6 1.0 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) NPIP PF06409.6 KOO29269.1 - 4 6.0 7.5 4.7 5.8 5.2 1.1 1 0 0 1 1 1 0 Nuclear pore complex interacting protein (NPIP) MAS20 PF02064.10 KOO29269.1 - 4.3 7.2 6.7 5.6 6.8 4.6 1.2 1 0 0 1 1 1 0 MAS20 protein import receptor BTV_NS2 PF04514.7 KOO29269.1 - 4.7 5.9 9.5 5.4 5.8 6.6 1.0 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 CCDC66 PF15236.1 KOO29269.1 - 8.1 6.0 24.1 10 5.7 16.7 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 66 Metallophos PF00149.23 KOO29270.1 - 3.8e-17 62.3 0.0 1.2e-16 60.6 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.1 KOO29270.1 - 2.7e-13 49.7 0.0 1.1e-12 47.8 0.0 2.1 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Metallophos_2 PF12850.2 KOO29270.1 - 0.00017 21.4 0.0 0.0003 20.6 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Ion_trans PF00520.26 KOO29271.1 - 7.1e-08 31.9 17.1 4.7e-07 29.2 11.9 2.0 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.7 KOO29271.1 - 1.9e-06 26.5 8.2 3.5e-06 25.7 5.7 1.5 1 1 0 1 1 1 1 Polycystin cation channel DUF2417 PF10329.4 KOO29271.1 - 0.21 10.9 9.7 0.45 9.8 6.7 1.4 1 0 0 1 1 1 0 Region of unknown function (DUF2417) IFT46_B_C PF12317.3 KOO29271.1 - 0.24 10.7 1.1 0.46 9.8 0.7 1.4 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal EF-hand_1 PF00036.27 KOO29272.1 - 7.8e-26 87.3 3.7 2.4e-05 23.3 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO29272.1 - 8.4e-24 81.2 5.2 3.2e-05 23.4 0.0 4.8 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO29272.1 - 1.7e-20 71.3 6.4 0.0002 20.5 0.1 4.7 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO29272.1 - 4.8e-18 65.0 1.3 7.2e-06 26.0 0.1 4.0 3 1 0 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO29272.1 - 6.5e-15 54.4 5.1 0.011 15.2 0.0 4.7 4 1 1 5 5 5 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO29272.1 - 1.9e-05 24.6 0.0 4.1 7.4 0.0 4.3 4 0 0 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region DUF2040 PF09745.4 KOO29272.1 - 0.034 13.9 6.4 0.37 10.6 0.8 2.6 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 55 (DUF2040) EF-hand_4 PF12763.2 KOO29272.1 - 0.12 12.1 0.1 12 5.7 0.0 3.0 3 0 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand Homeobox PF00046.24 KOO29275.1 - 2.7e-17 62.1 1.9 3.8e-17 61.6 1.3 1.2 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 KOO29275.1 - 7.1e-06 25.6 0.1 1.4e-05 24.6 0.1 1.5 1 0 0 1 1 1 1 Homeobox KN domain HTH_Tnp_1 PF01527.15 KOO29275.1 - 0.085 12.8 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Transposase HTH_28 PF13518.1 KOO29275.1 - 0.095 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain ACP_syn_III PF08545.5 KOO29276.1 - 0.047 13.3 0.2 0.068 12.8 0.1 1.3 1 1 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Transposase_22 PF02994.9 KOO29277.1 - 0.063 11.7 5.0 0.072 11.5 3.5 1.1 1 0 0 1 1 1 0 L1 transposable element IFT57 PF10498.4 KOO29277.1 - 0.97 8.1 9.3 1.1 7.9 6.4 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Nup88 PF10168.4 KOO29277.1 - 4.2 5.0 9.2 5.9 4.5 6.4 1.2 1 0 0 1 1 1 0 Nuclear pore component SNAPc19 PF15497.1 KOO29277.1 - 4.5 7.5 9.6 2.9 8.1 2.9 2.2 2 0 0 2 2 2 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 PCEMA1 PF07418.6 KOO29277.1 - 4.7 6.4 10.0 5.8 6.2 6.9 1.1 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 BCDHK_Adom3 PF10436.4 KOO29278.1 - 1.9e-12 47.0 0.2 2.9e-12 46.4 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 KOO29278.1 - 2.5e-05 23.9 0.0 4.2e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Kinesin PF00225.18 KOO29280.1 - 1.9e-51 174.7 0.0 1.6e-50 171.7 0.0 1.9 1 1 0 1 1 1 1 Kinesin motor domain DUF4573 PF15140.1 KOO29282.1 - 0.007 15.9 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4573) DUF350 PF03994.9 KOO29283.1 - 1.2e-24 85.7 54.5 8.6e-07 28.6 0.4 8.7 10 0 0 10 10 10 5 Domain of Unknown Function (DUF350) C2 PF00168.25 KOO29283.1 - 1.1e-23 82.8 0.0 1.4e-10 40.8 0.0 2.4 2 0 0 2 2 2 2 C2 domain Cupin_8 PF13621.1 KOO29284.1 - 5.5e-22 78.4 0.0 1.6e-21 76.9 0.0 1.8 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.17 KOO29284.1 - 7e-11 42.3 0.2 9.1e-09 35.5 0.1 3.1 2 1 0 2 2 2 1 JmjC domain, hydroxylase Cupin_4 PF08007.7 KOO29284.1 - 5.5e-05 22.5 0.0 9.4e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Cupin superfamily protein EF-hand_6 PF13405.1 KOO29285.1 - 1.5e-12 46.2 6.2 0.00014 21.4 0.1 4.6 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.1 KOO29285.1 - 3.3e-12 46.3 6.5 1.8e-05 24.7 0.2 4.1 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO29285.1 - 3.7e-12 44.6 8.8 5.9e-05 22.0 0.1 4.5 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO29285.1 - 2.1e-10 40.0 8.8 3.2e-07 29.8 0.5 3.5 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO29285.1 - 8.6e-07 28.0 13.6 0.0009 18.4 0.5 4.0 4 0 0 4 4 4 2 EF hand AraC_N PF06719.8 KOO29285.1 - 0.044 13.0 1.2 0.13 11.5 0.8 1.8 1 0 0 1 1 1 0 AraC-type transcriptional regulator N-terminus SPARC_Ca_bdg PF10591.4 KOO29285.1 - 0.26 11.3 7.4 2.3 8.2 0.0 3.9 2 2 2 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region Asp-B-Hydro_N PF05279.6 KOO29285.1 - 0.96 9.2 26.9 0.15 11.8 13.6 2.5 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region Sec62 PF03839.11 KOO29285.1 - 7.3 5.9 11.0 24 4.2 7.7 1.9 1 0 0 1 1 1 0 Translocation protein Sec62 Kinesin PF00225.18 KOO29289.1 - 6.2e-72 242.1 0.0 8.5e-72 241.6 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain DUF4043 PF13252.1 KOO29289.1 - 0.028 13.4 0.2 0.25 10.2 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4043) Vps53_N PF04100.7 KOO29291.1 - 5.9e-100 334.7 1.8 2.6e-99 332.6 1.2 2.0 1 1 0 1 1 1 1 Vps53-like, N-terminal Sec6 PF06046.8 KOO29291.1 - 1.2e-11 43.3 0.3 1.2e-11 43.3 0.2 2.1 2 0 0 2 2 2 1 Exocyst complex component Sec6 DUF2450 PF10475.4 KOO29291.1 - 6.9e-11 41.5 5.3 6.9e-11 41.5 3.7 2.0 3 0 0 3 3 3 1 Protein of unknown function N-terminal domain (DUF2450) COG2 PF06148.6 KOO29291.1 - 0.0002 21.2 2.9 0.00049 19.9 1.1 2.4 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 FAD_binding_5 PF00941.16 KOO29291.1 - 0.055 12.8 0.9 0.12 11.7 0.1 1.9 2 0 0 2 2 2 0 FAD binding domain in molybdopterin dehydrogenase Filo_VP35 PF02097.10 KOO29291.1 - 0.36 9.9 6.9 0.29 10.3 2.8 2.3 2 1 0 2 2 2 0 Filoviridae VP35 COG5 PF10392.4 KOO29291.1 - 0.56 10.1 5.8 1.6 8.7 2.1 2.9 1 1 1 2 2 2 0 Golgi transport complex subunit 5 PhaP_Bmeg PF09602.5 KOO29291.1 - 5.6 6.7 13.0 1.1 9.0 0.7 3.7 3 1 0 4 4 4 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) AAA_12 PF13087.1 KOO29296.1 - 4.5e-60 202.4 0.0 6.5e-60 201.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 KOO29296.1 - 3.7e-24 85.5 1.1 4.8e-22 78.6 0.0 2.8 2 1 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.13 KOO29296.1 - 3.3e-05 23.5 0.0 0.02 14.3 0.0 2.3 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase GAGA_bind PF06217.7 KOO29296.1 - 0.025 14.5 2.8 0.04 13.8 1.9 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family WD40 PF00400.27 KOO29297.1 - 1e-23 82.2 15.5 0.0094 15.8 0.0 9.0 9 0 0 9 9 9 7 WD domain, G-beta repeat HELP PF03451.9 KOO29297.1 - 1e-08 34.5 0.0 2.6e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 HELP motif Pkinase PF00069.20 KOO29298.1 - 3.9e-46 157.3 0.0 5.2e-46 156.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29298.1 - 4.5e-32 111.1 0.0 6e-32 110.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FdhE PF04216.7 KOO29298.1 - 0.032 13.9 3.6 0.042 13.5 2.5 1.3 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation Nnf1 PF03980.9 KOO29300.1 - 8.1e-07 29.0 3.5 1.3e-06 28.3 2.5 1.3 1 0 0 1 1 1 1 Nnf1 bZIP_2 PF07716.10 KOO29300.1 - 0.077 12.8 3.0 0.18 11.6 2.1 1.6 1 0 0 1 1 1 0 Basic region leucine zipper IncA PF04156.9 KOO29300.1 - 0.11 12.0 4.8 0.12 11.9 3.0 1.3 1 1 0 1 1 1 0 IncA protein HrpB7 PF09486.5 KOO29300.1 - 0.8 9.6 13.6 0.16 11.9 7.1 1.6 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) Cyclin_N PF00134.18 KOO29302.1 - 8.9e-46 154.5 2.1 8.9e-46 154.5 1.4 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 KOO29302.1 - 8.9e-33 112.7 0.1 2.1e-32 111.5 0.1 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain DSPc PF00782.15 KOO29303.1 - 9e-11 41.4 0.0 1.3e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KOO29303.1 - 0.011 15.0 0.0 0.016 14.5 0.0 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 KOO29303.1 - 0.03 14.5 0.1 0.063 13.5 0.1 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Helicase_C_3 PF13625.1 KOO29305.1 - 6.4e-25 87.3 0.0 1.3e-24 86.4 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO29305.1 - 5.7e-15 55.6 0.0 1.1e-14 54.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 KOO29305.1 - 7.6e-11 41.7 0.2 2.2e-10 40.2 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 KOO29305.1 - 1.1e-08 34.2 0.0 1.9e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain WD40 PF00400.27 KOO29307.1 - 1.2e-24 85.2 2.8 1.3e-13 50.2 0.2 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat PD40 PF07676.7 KOO29307.1 - 3.5e-05 23.3 0.1 0.32 10.7 0.0 2.4 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOO29307.1 - 0.017 14.8 0.0 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.1 KOO29307.1 - 0.036 13.1 0.1 1 8.4 0.0 2.0 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Nucleoporin_N PF08801.6 KOO29307.1 - 0.094 11.4 0.1 2.3 6.8 0.0 2.0 1 1 1 2 2 2 0 Nup133 N terminal like PAD_porph PF04371.10 KOO29308.1 - 3e-45 154.7 0.0 7.4e-22 77.8 0.0 2.0 2 0 0 2 2 2 2 Porphyromonas-type peptidyl-arginine deiminase E1-E2_ATPase PF00122.15 KOO29309.1 - 9.7e-39 132.7 0.0 1.9e-38 131.8 0.0 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 KOO29309.1 - 1.1e-30 107.6 9.1 1.1e-30 107.6 6.3 2.1 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO29309.1 - 2.8e-08 34.1 0.0 2.4e-07 31.0 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Ank_2 PF12796.2 KOO29310.1 - 1.3e-41 140.7 3.5 9.6e-18 64.3 0.1 2.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO29310.1 - 2.3e-17 63.0 0.1 5.9e-08 33.0 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO29310.1 - 2.4e-16 58.6 0.1 2.5e-07 30.1 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.1 KOO29310.1 - 4.7e-11 42.5 0.1 6.8e-07 29.3 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO29310.1 - 6.3e-11 41.4 0.0 0.00031 20.6 0.0 3.3 4 0 0 4 4 4 2 Ankyrin repeat MBOAT PF03062.14 KOO29312.1 - 1e-24 87.2 11.1 1.3e-24 86.9 7.7 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.1 KOO29312.1 - 0.011 15.7 5.6 0.028 14.4 3.9 1.7 1 0 0 1 1 1 0 Membrane bound O-acyl transferase family SMC_N PF02463.14 KOO29313.1 - 0.062 12.5 0.0 0.07 12.3 0.0 1.1 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain EGF_2 PF07974.8 KOO29314.1 - 1.1e-65 217.3 396.4 3e-05 24.0 3.9 20.5 20 0 0 20 20 20 20 EGF-like domain hEGF PF12661.2 KOO29314.1 - 6.1e-23 79.2 203.9 0.0022 17.9 1.0 22.6 20 0 0 20 20 20 17 Human growth factor-like EGF EGF PF00008.22 KOO29314.1 - 4.5e-06 26.4 310.4 0.014 15.3 1.0 21.1 20 0 0 20 20 20 17 EGF-like domain Rdx PF10262.4 KOO29315.1 - 0.0025 17.8 0.0 0.0039 17.1 0.0 1.5 1 0 0 1 1 1 1 Rdx family DivIC PF04977.10 KOO29315.1 - 0.01 15.3 0.3 0.041 13.3 0.2 2.0 1 0 0 1 1 1 1 Septum formation initiator Chloroa_b-bind PF00504.16 KOO29316.1 - 3.3e-32 111.9 0.1 4.4e-32 111.4 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein ART PF01129.13 KOO29317.1 - 8.5e-10 38.1 0.0 1.6e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.9 KOO29317.1 - 2.8e-08 33.1 0.0 6.3e-08 32.0 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme TrmB PF01978.14 KOO29317.1 - 0.00016 21.3 0.0 0.00028 20.5 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Chlorophyllase PF07224.6 KOO29318.1 - 0.17 10.6 0.0 0.27 9.9 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase PMSR PF01625.16 KOO29319.1 - 1.9 8.3 0.0 3.8 7.3 0.0 1.4 1 0 0 1 1 1 0 Peptide methionine sulfoxide reductase Rubredoxin PF00301.15 KOO29320.1 - 1.8e-07 30.9 1.7 4.6e-07 29.6 1.2 1.7 1 1 0 1 1 1 1 Rubredoxin DUF1610 PF07754.6 KOO29320.1 - 0.0015 18.5 1.0 0.019 15.0 0.7 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF1610) zf-ribbon_3 PF13248.1 KOO29320.1 - 0.03 13.5 1.0 1 8.6 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.7 KOO29320.1 - 0.062 12.6 2.2 3.7 6.9 0.2 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding TFIIS_C PF01096.13 KOO29320.1 - 0.83 9.3 5.4 7.9 6.2 0.1 3.3 3 0 0 3 3 3 0 Transcription factor S-II (TFIIS) zinc_ribbon_2 PF13240.1 KOO29320.1 - 0.98 8.9 4.0 2.7 7.5 0.5 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.2 KOO29320.1 - 3.4 7.5 6.3 3.9 7.3 0.0 3.1 3 0 0 3 3 3 0 Transposase zinc-ribbon domain Zn-ribbon_8 PF09723.5 KOO29320.1 - 6.4 6.8 7.3 40 4.2 5.1 2.2 1 1 0 1 1 1 0 Zinc ribbon domain DUF605 PF04652.11 KOO29321.1 - 1e-06 28.4 0.0 1e-06 28.4 0.0 2.8 1 1 2 3 3 3 1 Vta1 like Rhodanese PF00581.15 KOO29322.1 - 0.0019 18.5 0.0 0.0055 17.0 0.0 1.8 2 1 0 2 2 2 1 Rhodanese-like domain DUF2870 PF11069.3 KOO29323.1 - 1.7e-05 24.7 0.0 4.4e-05 23.4 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2870) Peptidase_S49 PF01343.13 KOO29324.1 - 1e-30 106.5 0.0 1.9e-30 105.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S49 Peptidase_S49_N PF08496.5 KOO29324.1 - 7.3e-14 51.8 0.1 3.9e-13 49.4 0.1 2.0 1 1 0 1 1 1 1 Peptidase family S49 N-terminal SDH_sah PF01972.11 KOO29324.1 - 0.0018 17.0 0.2 0.0028 16.4 0.1 1.2 1 0 0 1 1 1 1 Serine dehydrogenase proteinase CLP_protease PF00574.18 KOO29324.1 - 0.016 14.8 0.1 0.061 12.9 0.1 1.8 1 1 1 2 2 2 0 Clp protease Pkinase PF00069.20 KOO29325.1 - 2.7e-22 79.1 0.0 2.9e-22 79.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29325.1 - 1.7e-09 37.1 0.0 1.9e-09 36.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO29325.1 - 0.0084 15.1 0.0 0.0084 15.1 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 KOO29325.1 - 0.13 11.1 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Metallophos PF00149.23 KOO29326.1 - 9.5e-23 80.6 0.0 1.4e-22 80.0 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF1118 PF06549.7 KOO29326.1 - 6.2e-07 29.5 4.5 1.4e-06 28.4 3.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1118) IncA PF04156.9 KOO29326.1 - 4.5 6.8 6.5 8.8 5.8 4.5 1.4 1 0 0 1 1 1 0 IncA protein Band_7 PF01145.20 KOO29328.1 - 2.1e-26 92.8 2.1 4.3e-26 91.9 1.4 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family DUF2884 PF11101.3 KOO29328.1 - 0.032 13.6 0.3 0.061 12.7 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) DUF1049 PF06305.6 KOO29329.1 - 3.9 7.0 6.0 5.7 6.4 1.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) EF-hand_1 PF00036.27 KOO29330.1 - 3.8e-23 78.9 0.9 3e-05 23.0 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO29330.1 - 8.5e-21 71.9 2.5 4.8e-05 22.8 0.1 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO29330.1 - 2.9e-16 59.3 5.0 1.6e-08 34.5 0.6 3.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO29330.1 - 5.4e-11 41.3 7.9 0.0025 17.0 0.0 4.7 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.1 KOO29330.1 - 1.1e-10 41.0 6.8 0.0001 21.8 0.1 3.7 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_10 PF14788.1 KOO29330.1 - 0.00027 20.5 0.5 2.9 7.6 0.0 4.1 4 0 0 4 4 4 2 EF hand EF-hand_4 PF12763.2 KOO29330.1 - 0.0028 17.3 4.7 0.72 9.6 0.5 3.1 2 2 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand NPV_P10 PF05531.7 KOO29331.1 - 0.059 13.6 0.0 0.078 13.2 0.0 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.7 KOO29331.1 - 0.098 13.0 0.0 0.22 11.9 0.0 1.6 1 1 0 1 1 1 0 SlyX AAA PF00004.24 KOO29333.1 - 3.4e-24 85.5 0.0 1.4e-22 80.2 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SAM_MT PF04445.8 KOO29333.1 - 3.3e-05 23.1 0.0 7e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase AAA_5 PF07728.9 KOO29333.1 - 0.00021 21.0 0.0 0.0005 19.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Methyltransf_26 PF13659.1 KOO29333.1 - 0.0024 17.8 0.0 0.0089 16.0 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain AAA_16 PF13191.1 KOO29333.1 - 0.0028 17.6 0.0 0.0028 17.6 0.0 2.8 3 1 1 4 4 4 1 AAA ATPase domain AAA_25 PF13481.1 KOO29333.1 - 0.019 14.3 5.0 0.027 13.8 0.3 3.0 3 1 1 4 4 4 0 AAA domain TIP49 PF06068.8 KOO29333.1 - 0.065 11.9 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus AAA_22 PF13401.1 KOO29333.1 - 0.11 12.6 0.1 0.78 9.8 0.1 2.2 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 KOO29333.1 - 0.19 11.9 0.0 0.31 11.2 0.0 1.3 1 0 0 1 1 1 0 RNA helicase DUF3292 PF11696.3 KOO29335.1 - 0.37 8.6 3.8 0.5 8.1 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) RNase_H2-Ydr279 PF09468.5 KOO29335.1 - 0.57 9.3 3.8 0.72 8.9 2.6 1.2 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Herpes_DNAp_acc PF04929.7 KOO29335.1 - 5.8 5.7 6.6 7.5 5.3 4.6 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor WD40 PF00400.27 KOO29336.1 - 4.3e-11 42.2 23.0 0.00047 19.9 0.5 5.8 7 0 0 7 7 7 4 WD domain, G-beta repeat PQQ_3 PF13570.1 KOO29336.1 - 0.03 14.5 2.6 0.22 11.8 0.0 3.3 3 1 0 3 3 3 0 PQQ-like domain Mg_trans_NIPA PF05653.9 KOO29337.1 - 1.7e-18 66.6 8.7 3.2e-18 65.7 6.0 1.5 1 1 0 1 1 1 1 Magnesium transporter NIPA UPF0546 PF10639.4 KOO29337.1 - 0.025 14.4 0.5 0.051 13.4 0.3 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0546 PapC_C PF13953.1 KOO29337.1 - 0.17 11.5 0.3 0.46 10.1 0.0 1.8 2 0 0 2 2 2 0 PapC C-terminal domain Reo_sigmaC PF04582.7 KOO29338.1 - 1.9 7.5 15.0 0.35 10.0 1.3 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein EamA PF00892.15 KOO29339.1 - 6e-10 39.2 26.7 6.4e-06 26.2 5.0 2.3 2 1 0 2 2 2 2 EamA-like transporter family TPT PF03151.11 KOO29339.1 - 4.2e-07 29.7 10.5 4.2e-07 29.7 7.2 2.9 2 1 0 2 2 2 1 Triose-phosphate Transporter family EmrE PF13536.1 KOO29339.1 - 0.097 12.8 32.2 0.042 14.0 5.7 3.3 2 1 1 3 3 3 0 Multidrug resistance efflux transporter Glyco_hydro_81 PF03639.8 KOO29340.1 - 1.5e-104 350.4 0.0 5.4e-103 345.3 0.0 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 81 SprT-like PF10263.4 KOO29341.1 - 0.0038 16.9 0.0 0.0078 15.8 0.0 1.4 1 0 0 1 1 1 1 SprT-like family WLM PF08325.5 KOO29341.1 - 0.2 11.5 0.0 0.42 10.4 0.0 1.5 1 0 0 1 1 1 0 WLM domain Aa_trans PF01490.13 KOO29342.1 - 9.1e-31 106.7 14.6 1.2e-30 106.2 10.1 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Peptidase_C2 PF00648.16 KOO29343.1 - 6.6e-43 146.8 0.0 1.4e-42 145.7 0.0 1.5 1 1 0 1 1 1 1 Calpain family cysteine protease Acetyltransf_3 PF13302.1 KOO29343.1 - 3.3e-22 79.1 0.0 6.1e-22 78.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain EamA PF00892.15 KOO29343.1 - 2.2e-07 30.9 12.5 2.2e-07 30.9 8.7 3.0 2 1 1 3 3 3 2 EamA-like transporter family Acetyltransf_8 PF13523.1 KOO29343.1 - 3.4e-06 27.0 0.2 6.9e-06 26.0 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain TPT PF03151.11 KOO29343.1 - 2.6e-05 23.9 9.4 2.6e-05 23.9 6.5 2.4 2 1 0 2 2 2 1 Triose-phosphate Transporter family Acetyltransf_1 PF00583.19 KOO29343.1 - 0.00089 19.2 0.4 0.0018 18.2 0.3 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family EmrE PF13536.1 KOO29343.1 - 0.0016 18.5 12.3 0.0016 18.5 8.5 3.6 1 1 3 4 4 4 1 Multidrug resistance efflux transporter PX PF00787.19 KOO29344.1 - 1.5e-33 114.9 0.0 8.5e-16 57.7 0.0 2.5 2 0 0 2 2 2 2 PX domain GCC2_GCC3 PF07699.8 KOO29345.1 - 2.2e-26 91.1 58.0 4.8e-06 26.0 2.4 7.3 2 2 5 7 7 7 7 GCC2 and GCC3 NCD3G PF07562.9 KOO29345.1 - 1.6e-09 37.2 43.0 0.079 12.6 1.0 7.5 6 2 1 7 7 7 7 Nine Cysteines Domain of family 3 GPCR Methyltransf_32 PF13679.1 KOO29346.1 - 0.084 12.5 0.4 3.7 7.2 0.1 2.3 2 0 0 2 2 2 0 Methyltransferase domain RrnaAD PF00398.15 KOO29346.1 - 0.21 10.5 0.0 0.34 9.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase DUF2457 PF10446.4 KOO29346.1 - 8.5 4.9 15.2 14 4.2 10.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Abhydrolase_2 PF02230.11 KOO29347.1 - 1e-17 64.3 0.0 1.4e-17 63.8 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase PIH1 PF08190.7 KOO29347.1 - 2.5e-11 43.6 0.0 3.4e-11 43.1 0.0 1.1 1 0 0 1 1 1 1 pre-RNA processing PIH1/Nop17 Abhydrolase_5 PF12695.2 KOO29347.1 - 9.5e-08 31.9 0.1 1.9e-07 30.9 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.13 KOO29347.1 - 3.7e-07 29.6 0.0 5.9e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.2 KOO29347.1 - 1.2e-05 25.3 2.1 0.086 12.7 0.0 2.5 1 1 1 2 2 2 2 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 KOO29347.1 - 0.00067 18.9 0.1 0.028 13.6 0.0 2.1 1 1 1 2 2 2 1 Prolyl oligopeptidase family CS PF04969.11 KOO29347.1 - 0.003 18.0 0.0 0.0046 17.4 0.0 1.2 1 0 0 1 1 1 1 CS domain Esterase_phd PF10503.4 KOO29347.1 - 0.065 12.4 4.6 0.081 12.1 0.5 2.5 2 1 0 2 2 2 0 Esterase PHB depolymerase Abhydrolase_3 PF07859.8 KOO29347.1 - 0.87 9.1 4.0 0.79 9.2 0.1 2.4 2 1 1 3 3 3 0 alpha/beta hydrolase fold Arf PF00025.16 KOO29348.1 - 8.2e-48 161.9 0.0 1e-47 161.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 KOO29348.1 - 9.7e-11 42.2 0.0 1.3e-10 41.8 0.0 1.1 1 0 0 1 1 1 1 Miro-like protein SRPRB PF09439.5 KOO29348.1 - 2e-09 36.9 0.0 3e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 KOO29348.1 - 3.7e-09 35.7 0.0 4.5e-06 25.5 0.0 2.3 2 1 0 2 2 2 2 G-protein alpha subunit Ras PF00071.17 KOO29348.1 - 4.4e-08 32.6 0.0 6.5e-08 32.1 0.0 1.3 1 1 0 1 1 1 1 Ras family Gtr1_RagA PF04670.7 KOO29348.1 - 1e-07 31.3 0.0 1.2e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 KOO29348.1 - 1.6e-05 24.8 0.0 2.3e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 KOO29348.1 - 0.00046 19.6 0.0 0.0013 18.2 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.1 KOO29348.1 - 0.049 13.6 0.3 0.81 9.6 0.1 2.1 1 1 1 2 2 2 0 AAA ATPase domain Queuosine_synth PF02547.10 KOO29349.1 - 2.8e-93 312.3 0.0 1.7e-61 207.8 0.0 3.2 2 1 0 2 2 2 2 Queuosine biosynthesis protein DUF208 PF02677.9 KOO29349.1 - 1.8e-65 220.0 2.4 3.1e-65 219.2 1.7 1.4 1 0 0 1 1 1 1 Uncharacterized BCR, COG1636 Sel1 PF08238.7 KOO29350.1 - 1.2e-13 51.2 11.2 1.8e-06 28.4 0.6 4.3 4 0 0 4 4 4 3 Sel1 repeat U-box PF04564.10 KOO29350.1 - 3.3e-13 49.4 0.0 6.9e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO29350.1 - 0.0011 18.3 0.0 0.0022 17.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Sel1 PF08238.7 KOO29351.1 - 3.1e-14 53.0 15.1 8.8e-09 35.7 0.6 4.0 4 0 0 4 4 4 3 Sel1 repeat U-box PF04564.10 KOO29351.1 - 2.7e-12 46.4 0.0 4.8e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO29351.1 - 0.00052 19.4 0.1 0.0023 17.4 0.0 2.0 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit TPR_6 PF13174.1 KOO29351.1 - 0.016 15.6 3.0 0.16 12.5 0.2 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat Sigma70_r3 PF04539.11 KOO29351.1 - 0.056 13.3 0.1 0.056 13.3 0.1 2.1 2 0 0 2 2 2 0 Sigma-70 region 3 DUF1269 PF06897.7 KOO29353.1 - 0.0031 17.4 0.8 0.0056 16.6 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1269) CBF_beta PF02312.12 KOO29353.1 - 7.3 6.1 7.5 15 5.1 2.3 2.2 1 1 1 2 2 2 0 Core binding factor beta subunit DUF2324 PF10086.4 KOO29354.1 - 0.0002 20.6 1.0 0.00041 19.6 0.7 1.5 1 0 0 1 1 1 1 Putative membrane peptidase family (DUF2324) ABC_membrane PF00664.18 KOO29354.1 - 0.017 14.5 3.8 0.033 13.5 2.7 1.4 1 1 0 1 1 1 0 ABC transporter transmembrane region IncA PF04156.9 KOO29354.1 - 0.42 10.1 3.1 0.69 9.4 2.2 1.2 1 0 0 1 1 1 0 IncA protein Pkinase PF00069.20 KOO29356.1 - 1.5e-19 70.1 0.0 4.5e-19 68.6 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29356.1 - 4.7e-11 42.2 0.1 2.4e-10 39.9 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase ART PF01129.13 KOO29356.1 - 0.0083 15.2 0.0 0.0083 15.2 0.0 2.4 3 0 0 3 3 3 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.9 KOO29356.1 - 0.093 11.9 0.0 0.18 10.9 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosyltransferase exoenzyme Sel1 PF08238.7 KOO29360.1 - 7.3e-16 58.2 7.3 2.7e-06 27.8 0.2 4.1 4 0 0 4 4 4 3 Sel1 repeat U-box PF04564.10 KOO29360.1 - 4.6e-12 45.7 0.0 1e-11 44.5 0.0 1.6 2 0 0 2 2 2 1 U-box domain zf-Nse PF11789.3 KOO29360.1 - 0.00023 20.5 0.2 0.00086 18.7 0.0 2.0 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit Reprolysin_2 PF13574.1 KOO29360.1 - 0.0084 16.1 0.1 0.013 15.5 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Hydrophobin_2 PF06766.6 KOO29360.1 - 0.022 14.4 0.5 0.047 13.3 0.4 1.5 1 0 0 1 1 1 0 Fungal hydrophobin Sigma70_r3 PF04539.11 KOO29360.1 - 0.024 14.5 0.0 0.024 14.5 0.0 2.0 2 0 0 2 2 2 0 Sigma-70 region 3 CZB PF13682.1 KOO29360.1 - 0.029 14.5 0.3 0.086 13.0 0.2 1.8 1 0 0 1 1 1 0 Chemoreceptor zinc-binding domain APG12 PF04110.8 KOO29362.1 - 3.4e-24 84.8 0.0 3.9e-24 84.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.11 KOO29362.1 - 0.00064 19.6 0.0 0.00068 19.5 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like Amidohydro_1 PF01979.15 KOO29363.1 - 2.9e-17 63.3 0.0 4e-08 33.3 0.0 2.5 1 1 1 2 2 2 2 Amidohydrolase family Pribosyltran PF00156.22 KOO29363.1 - 9.7e-11 41.4 0.5 8.8e-10 38.3 0.0 2.3 2 0 0 2 2 2 1 Phosphoribosyl transferase domain Amidohydro_5 PF13594.1 KOO29363.1 - 3.3e-07 30.0 0.0 9.3e-07 28.5 0.0 1.8 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_3 PF07969.6 KOO29363.1 - 0.001 18.3 1.4 1.1 8.4 0.2 2.4 2 1 0 2 2 2 2 Amidohydrolase family UPRTase PF14681.1 KOO29363.1 - 0.0043 16.2 0.0 0.0077 15.4 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Xan_ur_permease PF00860.15 KOO29364.1 - 1.5e-33 115.8 33.6 7.5e-18 64.1 12.9 2.4 2 1 0 2 2 2 2 Permease family Response_reg PF00072.19 KOO29367.1 - 5.3e-08 32.8 0.0 1.3e-05 25.1 0.0 3.2 2 1 0 2 2 2 2 Response regulator receiver domain HMG_box PF00505.14 KOO29370.1 - 3.3e-15 56.0 0.0 4.1e-15 55.7 0.0 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO29370.1 - 1e-07 32.2 0.0 1.2e-07 32.0 0.0 1.2 1 0 0 1 1 1 1 HMG-box domain Exostosin PF03016.10 KOO29371.1 - 2.2e-34 118.8 0.0 2.9e-34 118.5 0.0 1.1 1 0 0 1 1 1 1 Exostosin family Sulfate_transp PF00916.15 KOO29373.1 - 2.4e-26 92.4 23.8 2.4e-26 92.4 16.5 4.1 3 1 0 3 3 3 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 KOO29373.1 - 1.7e-10 40.3 4.8 1.7e-10 40.3 3.3 3.9 3 0 0 3 3 3 1 Sulfate transporter N-terminal domain with GLY motif zf-C2H2 PF00096.21 KOO29374.1 - 0.64 10.4 2.9 1.3 9.5 2.0 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type PAN_1 PF00024.21 KOO29375.1 - 0.01 15.5 0.6 0.01 15.5 0.4 1.8 2 0 0 2 2 2 0 PAN domain E1_dh PF00676.15 KOO29376.1 - 2e-52 177.7 0.1 4.2e-52 176.7 0.1 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component Transketolase_C PF02780.15 KOO29376.1 - 1.3e-24 86.4 0.1 4.5e-24 84.7 0.0 1.9 1 0 0 1 1 1 1 Transketolase, C-terminal domain Transket_pyr PF02779.19 KOO29376.1 - 1.1e-14 54.3 0.3 3.4e-14 52.7 0.0 1.9 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain TPP_enzyme_C PF02775.16 KOO29376.1 - 5.9e-05 22.6 0.7 0.00038 20.0 0.0 2.7 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.1 KOO29376.1 - 0.0032 16.4 0.0 0.0067 15.3 0.0 1.5 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase Transketolase_N PF00456.16 KOO29376.1 - 0.038 12.7 0.0 0.075 11.8 0.0 1.4 1 0 0 1 1 1 0 Transketolase, thiamine diphosphate binding domain Hydrolase PF00702.21 KOO29377.1 - 8.6e-16 59.0 0.6 1.9e-14 54.5 0.4 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO29377.1 - 2.9e-14 53.6 0.0 7.5e-14 52.3 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOO29377.1 - 4.4e-10 39.3 0.1 2.2e-09 37.1 0.0 2.3 3 0 0 3 3 3 1 Putative hydrolase of sodium-potassium ATPase alpha subunit E1-E2_ATPase PF00122.15 KOO29377.1 - 2e-09 36.8 0.0 5.5e-09 35.3 0.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.7 KOO29377.1 - 0.00095 18.8 0.1 0.0019 17.8 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 KOO29379.1 - 1.8e-12 47.8 0.2 2.8e-07 30.9 0.0 2.6 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOO29379.1 - 1.6e-07 30.9 0.1 3e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 KOO29379.1 - 3.4e-05 24.3 0.0 5.9e-05 23.5 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Nucleotid_trans PF03407.11 KOO29380.1 - 1.5e-25 90.2 0.0 2.2e-25 89.6 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Kinesin PF00225.18 KOO29382.1 - 9.9e-107 356.4 2.3 1.4e-106 355.9 0.2 2.2 3 0 0 3 3 3 1 Kinesin motor domain DUF1637 PF07847.7 KOO29382.1 - 7.5e-38 129.9 0.0 7.8e-37 126.5 0.0 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1637) Rhodanese PF00581.15 KOO29382.1 - 1.9e-14 53.9 0.0 1.3e-13 51.2 0.0 2.3 2 0 0 2 2 2 1 Rhodanese-like domain AAA_16 PF13191.1 KOO29382.1 - 0.00024 21.1 9.5 0.00097 19.1 0.0 4.2 3 2 0 4 4 4 1 AAA ATPase domain CDO_I PF05995.7 KOO29382.1 - 0.00024 20.3 0.0 0.00065 18.9 0.0 1.7 1 0 0 1 1 1 1 Cysteine dioxygenase type I AAA_19 PF13245.1 KOO29382.1 - 0.00036 20.2 1.1 0.053 13.2 0.0 3.1 2 0 0 2 2 2 1 Part of AAA domain AAA_17 PF13207.1 KOO29382.1 - 0.0035 18.1 3.6 0.011 16.4 0.0 3.4 3 0 0 3 3 2 1 AAA domain T2SE PF00437.15 KOO29382.1 - 0.0035 16.2 0.6 0.14 11.0 0.0 2.6 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_22 PF13401.1 KOO29382.1 - 0.02 15.0 0.0 4.9 7.3 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.1 KOO29382.1 - 0.028 14.2 0.0 1 9.2 0.0 2.8 2 0 0 2 2 2 0 AAA domain ResIII PF04851.10 KOO29382.1 - 0.047 13.5 1.2 3.6 7.3 0.0 2.9 3 0 0 3 3 2 0 Type III restriction enzyme, res subunit AAA_18 PF13238.1 KOO29382.1 - 0.13 12.5 2.5 0.21 11.8 0.0 2.6 3 0 0 3 3 2 0 AAA domain AAA_23 PF13476.1 KOO29382.1 - 0.23 11.7 0.0 0.23 11.7 0.0 4.5 3 1 1 4 4 3 0 AAA domain Kelch_5 PF13854.1 KOO29383.1 - 5e-24 83.7 7.2 0.00015 21.6 0.0 6.7 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.1 KOO29383.1 - 2.6e-22 78.3 12.9 2.1e-05 24.1 0.0 6.6 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.1 KOO29383.1 - 1e-19 70.1 21.5 9.5e-09 35.1 0.0 7.1 8 0 0 8 8 8 5 Galactose oxidase, central domain ACBP PF00887.14 KOO29383.1 - 5.2e-18 64.4 0.2 8.7e-18 63.7 0.1 1.3 1 0 0 1 1 1 1 Acyl CoA binding protein Kelch_1 PF01344.20 KOO29383.1 - 5.9e-15 54.5 4.9 0.0076 15.7 0.0 6.1 7 0 0 7 7 7 4 Kelch motif Kelch_2 PF07646.10 KOO29383.1 - 5.5e-14 51.2 4.7 2.7e-05 23.7 0.0 6.1 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.1 KOO29383.1 - 2.8e-13 49.4 6.1 0.0015 18.6 0.0 6.4 5 1 1 6 6 6 4 Kelch motif RAG2 PF03089.9 KOO29383.1 - 0.15 10.7 0.1 16 4.0 0.0 2.5 2 0 0 2 2 2 0 Recombination activating protein 2 Cyto_heme_lyase PF01265.12 KOO29384.1 - 2.5e-45 155.1 0.0 3e-45 154.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase Hexapep PF00132.19 KOO29385.1 - 8.6e-15 53.4 3.2 0.0007 18.9 0.0 4.4 3 1 2 5 5 5 5 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 KOO29385.1 - 0.039 13.5 7.9 0.24 11.0 1.2 4.0 2 1 1 3 3 3 0 Hexapeptide repeat of succinyl-transferase PPR_3 PF13812.1 KOO29386.1 - 3.2e-06 26.9 0.2 0.0016 18.5 0.0 2.8 2 1 1 3 3 3 1 Pentatricopeptide repeat domain Smr PF01713.16 KOO29386.1 - 1.3e-05 25.3 0.0 4.1e-05 23.6 0.0 1.8 2 0 0 2 2 2 1 Smr domain PPR PF01535.15 KOO29386.1 - 7.4e-05 22.4 0.1 0.024 14.5 0.0 2.8 3 0 0 3 3 3 1 PPR repeat TPR_14 PF13428.1 KOO29386.1 - 0.00029 21.1 6.9 0.23 12.1 0.3 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO29386.1 - 0.00062 19.3 2.2 0.8 9.6 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.1 KOO29386.1 - 0.017 15.5 2.3 1.3 9.6 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 KOO29386.1 - 0.021 15.1 0.2 0.021 15.1 0.1 1.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO29386.1 - 0.037 13.9 1.2 0.36 10.8 0.4 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat Apc3 PF12895.2 KOO29386.1 - 0.045 13.8 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 PPR_2 PF13041.1 KOO29386.1 - 0.085 12.8 0.0 2.4 8.1 0.0 2.7 2 1 1 3 3 3 0 PPR repeat family GMC_oxred_N PF00732.14 KOO29387.1 - 5e-45 153.9 0.2 2.5e-42 145.0 0.2 3.0 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 KOO29387.1 - 1.2e-32 113.2 0.1 2.3e-32 112.2 0.1 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FPN1 PF06963.7 KOO29389.1 - 1e-54 185.5 12.8 4.5e-27 94.5 6.7 2.4 1 1 1 2 2 2 2 Ferroportin1 (FPN1) PQ-loop PF04193.9 KOO29389.1 - 9.6e-31 105.1 6.6 1.6e-16 59.5 3.0 3.0 2 0 0 2 2 2 2 PQ loop repeat Glyco_hydro_2_C PF02836.12 KOO29391.1 - 3.4e-88 295.4 0.0 1.1e-87 293.7 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.13 KOO29391.1 - 1.7e-38 131.8 0.0 3.2e-26 91.8 0.0 2.3 2 0 0 2 2 2 2 Glycosyl hydrolases family 2, sugar binding domain Bgal_small_N PF02929.12 KOO29391.1 - 1.1e-36 126.3 0.0 2.1e-36 125.3 0.0 1.5 1 1 0 1 1 1 1 Beta galactosidase small chain Glyco_hydro_2 PF00703.16 KOO29391.1 - 3e-09 37.2 0.0 3.8e-08 33.7 0.0 2.3 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Tfb4 PF03850.9 KOO29392.1 - 5e-33 114.5 6.7 9.3e-33 113.6 0.1 2.2 2 0 0 2 2 2 2 Transcription factor Tfb4 Ank_5 PF13857.1 KOO29393.1 - 8.8e-07 28.9 0.0 1.7e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO29393.1 - 2.9e-06 27.5 0.0 5.6e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO29393.1 - 6.5e-05 23.3 0.1 0.00015 22.1 0.0 1.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO29393.1 - 0.0014 18.6 0.1 4.4 7.8 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.25 KOO29393.1 - 0.0015 18.2 0.1 2.4 8.1 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 KOO29394.1 - 1.6e-30 105.3 0.2 4.3e-14 52.6 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO29394.1 - 1.5e-26 90.8 1.9 1.2e-06 28.0 0.5 6.4 6 0 0 6 6 6 6 Ankyrin repeat Ank_5 PF13857.1 KOO29394.1 - 1.4e-22 79.2 3.4 2.3e-07 30.8 0.0 4.7 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO29394.1 - 2.4e-21 75.6 0.3 9.5e-07 29.1 0.0 4.0 3 2 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO29394.1 - 8e-19 65.8 0.1 0.00013 21.9 0.1 6.3 6 0 0 6 6 6 5 Ankyrin repeat AAA_13 PF13166.1 KOO29394.1 - 1.9 6.8 6.0 2.9 6.2 4.2 1.1 1 0 0 1 1 1 0 AAA domain DUF2457 PF10446.4 KOO29395.1 - 0.0026 16.5 16.0 0.0026 16.5 11.1 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2457) Daxx PF03344.10 KOO29395.1 - 0.048 12.1 12.4 0.055 11.9 8.6 1.1 1 0 0 1 1 1 0 Daxx Family NOA36 PF06524.7 KOO29395.1 - 0.098 11.8 12.7 0.18 11.0 8.8 1.4 1 0 0 1 1 1 0 NOA36 protein DUF1510 PF07423.6 KOO29395.1 - 0.24 10.7 9.5 0.39 10.0 6.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CDC45 PF02724.9 KOO29395.1 - 0.9 7.4 10.1 1 7.2 7.0 1.1 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.6 KOO29395.1 - 1.3 7.0 3.5 1.5 6.8 2.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SDA1 PF05285.7 KOO29395.1 - 1.5 7.9 14.7 1.9 7.7 10.2 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.7 KOO29395.1 - 3.3 5.5 18.6 3.5 5.4 12.9 1.1 1 0 0 1 1 1 0 Nop14-like family PPP4R2 PF09184.6 KOO29395.1 - 3.8 6.9 13.5 6.3 6.2 9.3 1.3 1 0 0 1 1 1 0 PPP4R2 YqaJ PF09588.5 KOO29396.1 - 2.9e-29 101.9 0.0 4.1e-29 101.5 0.0 1.2 1 0 0 1 1 1 1 YqaJ-like viral recombinase domain DEAD PF00270.24 KOO29398.1 - 1.8e-27 95.9 0.0 2.4e-27 95.4 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase SNF2_N PF00176.18 KOO29398.1 - 0.00033 19.5 0.0 0.00043 19.1 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 KOO29398.1 - 0.0054 16.5 0.0 0.0075 16.1 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit COX17 PF05051.8 KOO29399.1 - 0.073 13.1 0.6 0.15 12.1 0.2 1.7 2 0 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) ATP-synt_Eps PF04627.8 KOO29399.1 - 0.48 10.0 2.0 0.88 9.1 1.0 2.0 1 1 0 1 1 1 0 Mitochondrial ATP synthase epsilon chain Bravo_FIGEY PF13882.1 KOO29400.1 - 0.38 11.7 7.1 3.5 8.6 1.5 2.4 2 0 0 2 2 2 0 Bravo-like intracellular region ShK PF01549.19 KOO29400.1 - 0.4 11.0 12.8 15 6.0 0.1 4.4 4 1 0 4 4 4 0 ShK domain-like Chromo PF00385.19 KOO29401.1 - 3e-07 30.0 0.0 1.2e-05 24.8 0.0 2.2 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain DUF3653 PF12375.3 KOO29401.1 - 0.041 14.0 2.0 9 6.5 0.0 3.6 2 1 1 3 3 3 0 Phage protein Mtf2_C PF14061.1 KOO29401.1 - 0.045 13.6 0.5 0.15 12.0 0.0 2.1 2 0 0 2 2 2 0 Polycomb-like MTF2 factor 2 DUF382 PF04037.8 KOO29402.1 - 1.1e-46 157.8 1.9 4.1e-28 97.7 0.0 2.6 1 1 1 2 2 2 2 Domain of unknown function (DUF382) PSP PF04046.11 KOO29402.1 - 2.2e-20 71.7 5.3 4.7e-20 70.7 3.3 1.8 2 0 0 2 2 2 1 PSP Cation_efflux PF01545.16 KOO29403.1 - 1.1e-39 136.1 8.0 1.5e-39 135.7 5.5 1.1 1 0 0 1 1 1 1 Cation efflux family Kelch_1 PF01344.20 KOO29404.1 - 1.8e-92 302.6 0.0 1.5e-17 62.8 0.0 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.1 KOO29404.1 - 1.4e-56 186.4 0.0 2.7e-11 43.1 0.0 6.4 1 1 5 6 6 6 6 Kelch motif Kelch_2 PF07646.10 KOO29404.1 - 5.2e-49 162.2 0.0 9.5e-08 31.5 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.1 KOO29404.1 - 2.2e-48 161.7 0.2 2.2e-08 33.7 0.0 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.1 KOO29404.1 - 1.9e-45 152.0 5.8 1.1e-10 41.3 0.0 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO29404.1 - 6.5e-23 80.2 7.2 0.00023 21.0 0.0 6.7 6 0 0 6 6 6 4 Kelch motif BACK PF07707.10 KOO29404.1 - 2.7e-18 65.6 0.0 4.6e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.26 KOO29404.1 - 5.3e-14 52.1 0.0 1.2e-13 50.9 0.0 1.6 2 0 0 2 2 1 1 BTB/POZ domain DUF1668 PF07893.8 KOO29404.1 - 7.3e-06 25.3 1.6 0.28 10.2 0.0 4.8 1 1 5 6 6 6 1 Protein of unknown function (DUF1668) PQQ_3 PF13570.1 KOO29404.1 - 0.00031 20.9 16.4 13 6.2 0.1 6.1 7 0 0 7 7 5 0 PQQ-like domain Glyoxal_oxid_N PF07250.6 KOO29404.1 - 0.00066 18.8 0.1 0.21 10.6 0.0 2.3 1 1 1 2 2 2 2 Glyoxal oxidase N-terminus Skp1 PF01466.14 KOO29404.1 - 0.009 16.0 0.2 0.019 14.9 0.2 1.5 1 0 0 1 1 1 1 Skp1 family, dimerisation domain TBSV_P22 PF03558.8 KOO29404.1 - 0.017 14.5 0.0 1.9 7.8 0.0 2.8 1 1 2 3 3 3 0 TBSV core protein P21/P22 DUF721 PF05258.7 KOO29404.1 - 0.017 15.2 0.0 5.1 7.3 0.0 3.6 4 1 1 5 5 5 0 Protein of unknown function (DUF721) Peptidase_S9_N PF02897.10 KOO29404.1 - 0.15 10.5 0.0 0.28 9.6 0.0 1.4 1 1 0 1 1 1 0 Prolyl oligopeptidase, N-terminal beta-propeller domain Cupin_8 PF13621.1 KOO29405.1 - 1.6e-10 40.9 0.0 2.1e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 KOO29405.1 - 9.7e-06 25.0 0.1 3.3e-05 23.2 0.1 1.7 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.17 KOO29405.1 - 1.6e-05 25.0 0.0 3.4e-05 24.0 0.0 1.6 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cu-oxidase_2 PF07731.9 KOO29405.1 - 0.013 15.0 0.1 0.019 14.4 0.0 1.3 1 0 0 1 1 1 0 Multicopper oxidase TPR_11 PF13414.1 KOO29406.1 - 9.7e-05 21.9 3.5 0.00069 19.2 0.1 3.2 3 0 0 3 3 3 1 TPR repeat TPR_2 PF07719.12 KOO29406.1 - 0.00012 21.6 12.1 0.29 11.1 0.1 4.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO29406.1 - 0.00019 20.9 0.9 0.14 12.0 0.0 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO29406.1 - 0.00021 20.7 3.8 1.5 8.5 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO29406.1 - 0.00079 20.0 0.8 0.00079 20.0 0.6 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO29406.1 - 0.0059 16.9 3.1 0.015 15.6 0.1 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO29406.1 - 0.017 14.9 1.5 2.4 8.1 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.1 KOO29406.1 - 0.029 14.5 0.6 0.38 11.0 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO29406.1 - 0.18 12.5 0.3 0.18 12.5 0.2 5.5 4 1 2 6 6 5 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO29406.1 - 2.1 8.3 10.5 0.59 10.1 0.8 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.9 KOO29406.1 - 8 7.2 26.7 0.44 11.1 1.0 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat IF-2B PF01008.12 KOO29407.1 - 2.9e-67 226.6 0.0 3.6e-67 226.3 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Sigma54_CBD PF04963.8 KOO29407.1 - 0.039 13.3 0.0 0.064 12.6 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 factor, core binding domain LRR_4 PF12799.2 KOO29410.1 - 2.5e-23 81.2 9.7 7.4e-10 38.2 0.0 4.8 2 2 3 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO29410.1 - 4.7e-12 45.4 6.4 3.2e-08 33.2 0.4 3.2 2 1 2 4 4 4 2 Leucine rich repeat LRR_1 PF00560.28 KOO29410.1 - 2e-08 33.1 4.7 2.5 8.4 0.0 5.5 5 1 0 5 5 5 4 Leucine Rich Repeat LRR_9 PF14580.1 KOO29410.1 - 6.2e-07 29.1 1.4 0.025 14.1 0.1 2.3 1 1 0 2 2 2 2 Leucine-rich repeat LRR_7 PF13504.1 KOO29410.1 - 1.9e-06 27.1 6.5 5.5 7.6 0.0 5.8 6 1 0 6 6 6 3 Leucine rich repeat LRR_6 PF13516.1 KOO29410.1 - 1e-05 25.0 10.0 2.3 8.5 0.4 5.7 5 1 0 5 5 5 2 Leucine Rich repeat Glucosamine_iso PF01182.15 KOO29411.1 - 8.9e-60 201.8 0.0 1.6e-59 200.9 0.0 1.4 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase PAN_4 PF14295.1 KOO29412.1 - 3.9e-08 32.8 8.9 3.9e-08 32.8 6.2 1.7 2 0 0 2 2 2 1 PAN domain Pro_isomerase PF00160.16 KOO29412.1 - 7e-05 23.0 0.0 9.9e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Exo_endo_phos PF03372.18 KOO29413.1 - 3.8e-10 40.1 0.5 7.7e-10 39.1 0.3 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-C3HC4_2 PF13923.1 KOO29414.1 - 2.1e-07 30.8 6.2 8.5e-07 28.9 4.3 2.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-TRAF PF02176.13 KOO29414.1 - 8.6e-05 22.8 1.8 8.6e-05 22.8 1.2 3.1 2 1 1 3 3 3 1 TRAF-type zinc finger zf-RING_2 PF13639.1 KOO29414.1 - 0.00075 19.2 3.4 0.00075 19.2 2.4 3.0 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.20 KOO29414.1 - 0.0029 17.2 1.7 0.0029 17.2 1.2 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) ADIP PF11559.3 KOO29414.1 - 0.024 14.5 1.6 0.32 10.8 0.3 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Sina PF03145.11 KOO29414.1 - 0.057 13.0 6.3 1.6 8.3 0.3 2.5 1 1 1 2 2 2 0 Seven in absentia protein family zf-C3HC4_3 PF13920.1 KOO29414.1 - 0.39 10.4 8.6 0.089 12.4 3.2 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO29414.1 - 1.4 8.7 9.6 2.3 8.0 2.0 2.9 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_4 PF15227.1 KOO29414.1 - 8.3 6.3 8.3 8.4 6.3 4.1 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING CS PF04969.11 KOO29416.1 - 5.6e-11 42.8 0.2 7.6e-11 42.4 0.1 1.2 1 0 0 1 1 1 1 CS domain GvpH PF05455.6 KOO29416.1 - 0.064 12.8 0.1 0.08 12.5 0.1 1.2 1 0 0 1 1 1 0 GvpH Serinc PF03348.10 KOO29417.1 - 5.9e-79 265.7 27.9 1.1e-78 264.9 19.4 1.3 1 1 0 1 1 1 1 Serine incorporator (Serinc) YL1 PF05764.8 KOO29418.1 - 8.6 5.8 14.8 1e+02 2.3 10.3 2.2 1 1 0 1 1 1 0 YL1 nuclear protein XendoU PF09412.5 KOO29419.1 - 2.7e-43 147.9 0.1 3e-43 147.7 0.1 1.0 1 0 0 1 1 1 1 Endoribonuclease XendoU zf-C2H2 PF00096.21 KOO29420.1 - 4.6e-12 45.5 19.3 5.6e-05 23.2 1.3 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOO29420.1 - 6.8e-09 35.4 12.2 0.023 14.9 0.6 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KOO29420.1 - 1.2e-06 28.4 8.2 0.0047 17.0 0.1 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 KOO29420.1 - 0.0017 18.5 17.4 0.27 11.5 2.9 3.9 4 1 0 4 4 3 2 Zinc-finger double domain zf-met PF12874.2 KOO29420.1 - 0.0019 18.3 6.2 0.1 12.8 0.4 3.2 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 KOO29420.1 - 0.0065 16.3 11.1 0.055 13.4 0.1 3.7 3 1 0 3 3 3 2 C2H2-type zinc finger HypA PF01155.14 KOO29420.1 - 0.13 12.0 2.3 0.34 10.6 1.6 1.6 1 1 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zf-Di19 PF05605.7 KOO29420.1 - 0.38 10.9 6.8 7.1 6.8 1.6 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-trcl PF13451.1 KOO29420.1 - 0.45 10.1 7.9 0.069 12.7 1.9 2.2 2 0 0 2 2 2 0 Probable zinc-binding domain zf-BED PF02892.10 KOO29420.1 - 0.51 10.1 6.1 7.4 6.4 0.0 2.7 2 1 0 2 2 2 0 BED zinc finger Prok-RING_1 PF14446.1 KOO29420.1 - 1.6 8.5 8.4 18 5.1 0.0 3.3 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 C1_4 PF07975.7 KOO29420.1 - 1.9 8.5 5.9 38 4.3 0.0 2.7 2 1 1 3 3 3 0 TFIIH C1-like domain zf-C2H2_2 PF12756.2 KOO29420.1 - 3.8 7.6 11.3 9 6.4 0.1 3.1 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_5 PF13719.1 KOO29420.1 - 8.6 6.0 7.3 21 4.8 0.1 3.2 3 0 0 3 3 3 0 zinc-ribbon domain Indigoidine_A PF04227.7 KOO29421.1 - 3e-104 348.3 3.0 3.8e-104 348.0 2.1 1.0 1 0 0 1 1 1 1 Indigoidine synthase A like protein TPP_enzyme_N PF02776.13 KOO29421.1 - 0.0039 16.6 2.4 0.0081 15.6 0.2 2.1 1 1 1 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain CcoS PF03597.10 KOO29422.1 - 0.2 11.1 1.8 0.42 10.1 1.3 1.5 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type Kinesin PF00225.18 KOO29423.1 - 7.1e-27 93.9 0.0 1.2e-14 53.8 0.0 3.1 2 1 1 3 3 3 3 Kinesin motor domain ERp29_N PF07912.8 KOO29424.1 - 3.1e-30 104.6 0.4 6.3e-30 103.7 0.3 1.5 1 0 0 1 1 1 1 ERp29, N-terminal domain ERp29 PF07749.7 KOO29424.1 - 6.6e-24 84.3 3.0 1.2e-23 83.5 2.1 1.4 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain Flagellin_D3 PF08884.6 KOO29424.1 - 0.082 13.1 2.9 0.2 11.8 2.0 1.7 1 1 0 1 1 1 0 Flagellin D3 domain DPCD PF14913.1 KOO29425.1 - 6.9e-65 217.8 0.6 8.8e-65 217.4 0.4 1.0 1 0 0 1 1 1 1 DPCD protein family UBA PF00627.26 KOO29426.1 - 0.00017 21.3 0.4 0.00085 19.0 0.0 2.5 2 0 0 2 2 2 1 UBA/TS-N domain SAP PF02037.22 KOO29426.1 - 0.0089 15.5 0.3 0.15 11.6 0.2 3.0 1 1 0 1 1 1 1 SAP domain UBA_4 PF14555.1 KOO29426.1 - 0.019 14.5 0.0 0.07 12.6 0.0 2.0 1 0 0 1 1 1 0 UBA-like domain CENP-F_leu_zip PF10473.4 KOO29426.1 - 0.019 14.7 0.3 0.019 14.7 0.2 2.8 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Reo_sigmaC PF04582.7 KOO29426.1 - 1.2 8.2 14.0 0.67 9.0 1.7 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DUF3584 PF12128.3 KOO29426.1 - 8.2 3.6 35.1 14 2.8 24.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) cNMP_binding PF00027.24 KOO29427.1 - 1.8e-30 104.6 0.0 4e-13 49.0 0.0 3.9 3 1 0 3 3 3 2 Cyclic nucleotide-binding domain EF-hand_1 PF00036.27 KOO29427.1 - 1.3e-09 36.6 0.1 0.00025 20.1 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO29427.1 - 4.5e-08 33.0 1.0 3.2e-05 23.9 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO29427.1 - 3.2e-07 29.6 0.2 0.0076 16.0 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO29427.1 - 7.7e-07 28.1 4.0 0.0039 16.4 0.3 3.5 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO29427.1 - 0.0001 21.8 0.0 0.00034 20.1 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain pair Lipocalin_2 PF08212.7 KOO29428.1 - 1.1e-17 64.1 0.0 1.3e-17 63.9 0.0 1.1 1 0 0 1 1 1 1 Lipocalin-like domain PARP PF00644.15 KOO29429.1 - 3.8e-16 59.1 0.0 6.2e-16 58.4 0.0 1.3 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain zf-CW PF07496.10 KOO29430.1 - 5.8e-06 25.9 1.8 1e-05 25.1 1.3 1.4 1 0 0 1 1 1 1 CW-type Zinc Finger DRY_EERY PF09750.4 KOO29430.1 - 0.031 14.3 1.9 0.046 13.8 1.3 1.2 1 0 0 1 1 1 0 Alternative splicing regulator DUF3381 PF11861.3 KOO29430.1 - 4.4 6.7 8.5 5.7 6.4 5.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) RYDR_ITPR PF01365.16 KOO29431.1 - 0.24 10.5 0.0 0.39 9.9 0.0 1.2 1 0 0 1 1 1 0 RIH domain mRNA_triPase PF02940.10 KOO29432.1 - 1.3e-08 34.8 0.0 2.1e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain Ion_trans_2 PF07885.11 KOO29433.1 - 5.9e-28 96.4 21.9 8.3e-15 54.2 6.8 2.2 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.26 KOO29433.1 - 1.2e-05 24.6 10.9 0.0024 17.1 1.6 2.5 2 1 0 2 2 2 2 Ion transport protein EF-hand_5 PF13202.1 KOO29433.1 - 0.0023 17.1 5.4 0.01 15.1 0.0 2.8 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.1 KOO29433.1 - 0.0034 17.1 1.3 0.016 15.0 0.0 2.6 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.27 KOO29433.1 - 0.004 16.3 2.1 0.034 13.4 0.0 3.0 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.1 KOO29433.1 - 0.013 15.5 0.2 0.078 13.1 0.0 2.2 2 1 0 2 2 2 0 EF-hand domain pair DUF4261 PF14080.1 KOO29435.1 - 0.23 11.2 0.0 0.48 10.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4261) DivIC PF04977.10 KOO29435.1 - 0.24 10.8 0.7 0.61 9.6 0.5 1.7 1 0 0 1 1 1 0 Septum formation initiator EF-hand_6 PF13405.1 KOO29436.1 - 0.00031 20.3 0.1 0.0007 19.2 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.1 KOO29436.1 - 0.00064 19.2 0.1 0.0011 18.5 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.1 KOO29436.1 - 0.0017 18.4 0.0 0.0029 17.6 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO29436.1 - 0.0047 16.2 0.0 0.009 15.3 0.0 1.5 1 0 0 1 1 1 1 EF hand CTF_NFI PF00859.13 KOO29436.1 - 0.009 15.8 0.1 0.014 15.2 0.1 1.2 1 0 0 1 1 1 1 CTF/NF-I family transcription modulation region EF-hand_1 PF00036.27 KOO29436.1 - 0.011 15.0 0.0 0.02 14.2 0.0 1.5 1 0 0 1 1 1 0 EF hand DUF3560 PF12083.3 KOO29436.1 - 0.094 12.7 0.2 1.9 8.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3560) Ank_2 PF12796.2 KOO29437.1 - 6.5e-28 96.9 2.1 1.3e-17 63.9 0.3 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO29437.1 - 1.5e-24 84.4 10.4 1.3e-09 37.3 0.5 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.1 KOO29437.1 - 5.3e-20 69.5 1.8 2.8e-07 30.1 0.2 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 KOO29437.1 - 9.3e-20 70.2 5.0 3.8e-07 30.1 0.5 3.8 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO29437.1 - 7.8e-16 58.1 0.4 2.9e-09 37.1 0.1 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) AAA PF00004.24 KOO29438.1 - 5.5e-10 39.5 0.0 9.6e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 KOO29438.1 - 0.00012 21.7 0.0 0.00038 20.1 0.0 1.9 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 KOO29438.1 - 0.0012 18.5 0.0 0.0032 17.2 0.0 1.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOO29438.1 - 0.0027 17.7 0.0 0.0071 16.3 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.8 KOO29438.1 - 0.0035 16.1 0.0 0.005 15.6 0.0 1.1 1 0 0 1 1 1 1 TIP49 C-terminus IstB_IS21 PF01695.12 KOO29438.1 - 0.0038 16.6 0.0 0.0063 15.9 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.1 KOO29438.1 - 0.0039 17.3 0.0 0.0081 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 KOO29438.1 - 0.0041 16.3 0.0 0.0082 15.3 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.1 KOO29438.1 - 0.0055 16.6 0.2 0.018 14.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 KOO29438.1 - 0.0072 17.1 0.0 0.033 15.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.1 KOO29438.1 - 0.0082 16.4 0.0 0.024 14.9 0.0 1.8 2 0 0 2 2 1 1 AAA domain RuvB_N PF05496.7 KOO29438.1 - 0.015 14.3 0.0 0.024 13.6 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_24 PF13479.1 KOO29438.1 - 0.016 14.7 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 KOO29438.1 - 0.019 14.8 0.6 0.043 13.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 KOO29438.1 - 0.047 12.7 0.0 0.091 11.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin PhoH PF02562.11 KOO29438.1 - 0.12 11.6 0.1 0.2 10.8 0.1 1.2 1 0 0 1 1 1 0 PhoH-like protein Arch_ATPase PF01637.13 KOO29438.1 - 0.24 11.0 0.0 0.34 10.5 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase LRR_6 PF13516.1 KOO29439.1 - 8.1e-21 71.7 44.5 0.06 13.4 0.1 18.2 20 0 0 20 20 20 7 Leucine Rich repeat LRR_1 PF00560.28 KOO29439.1 - 1.2e-07 30.7 19.8 6.5 7.1 0.1 11.7 15 1 1 16 16 15 2 Leucine Rich Repeat FIBP PF05427.6 KOO29439.1 - 0.00013 21.3 0.3 0.1 11.8 0.0 3.7 4 0 0 4 4 4 1 Acidic fibroblast growth factor binding (FIBP) LRR_4 PF12799.2 KOO29439.1 - 0.00021 20.8 16.3 0.83 9.3 0.0 8.0 8 3 1 9 9 9 2 Leucine Rich repeats (2 copies) Metal_CEHH PF14455.1 KOO29439.1 - 0.0086 15.4 0.7 3.5 6.9 0.0 3.5 4 1 1 5 5 5 1 Predicted metal binding domain LRR_8 PF13855.1 KOO29439.1 - 0.015 15.0 23.5 6.8 6.5 0.3 8.5 6 4 2 8 8 8 0 Leucine rich repeat SLT_L PF14718.1 KOO29439.1 - 0.021 14.5 0.6 24 4.8 0.0 4.0 4 0 0 4 4 4 0 Soluble lytic murein transglycosylase L domain Mg_chelatase_2 PF13335.1 KOO29439.1 - 0.038 14.3 0.9 56 4.2 0.0 4.1 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI EIF_2_alpha PF07541.7 KOO29439.1 - 0.073 12.7 1.2 8 6.2 0.0 4.6 7 1 1 8 8 8 0 Eukaryotic translation initiation factor 2 alpha subunit DUF902 PF06001.8 KOO29439.1 - 0.1 12.7 0.9 1.3e+02 2.8 0.0 4.0 4 0 0 4 4 4 0 Domain of Unknown Function (DUF902) ORF6C PF10552.4 KOO29439.1 - 0.39 10.4 1.9 9.4 5.9 0.1 3.5 4 0 0 4 4 4 0 ORF6C domain UBA PF00627.26 KOO29440.1 - 9.1e-07 28.5 0.1 5.8e-06 25.9 0.1 2.5 1 0 0 1 1 1 1 UBA/TS-N domain CUE PF02845.11 KOO29440.1 - 0.016 14.7 0.0 0.042 13.3 0.0 1.7 1 0 0 1 1 1 0 CUE domain DUF964 PF06133.6 KOO29440.1 - 4.1 7.4 7.8 18 5.3 5.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF964) Glyco_hydro_85 PF03644.8 KOO29442.1 - 8.9e-67 225.4 0.0 1.3e-66 224.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 LSM PF01423.17 KOO29442.1 - 2.4e-16 59.0 0.3 4.2e-16 58.2 0.2 1.4 1 0 0 1 1 1 1 LSM domain PUB PF09409.5 KOO29442.1 - 2.4e-15 56.0 0.0 4.2e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 PUB domain YlqD PF11068.3 KOO29443.1 - 7.5 6.6 8.9 0.84 9.6 0.4 2.5 2 0 0 2 2 2 0 YlqD protein Ank_2 PF12796.2 KOO29445.1 - 0.0019 18.5 0.8 0.066 13.5 0.3 3.2 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO29445.1 - 0.022 14.9 0.2 1.1 9.7 0.0 3.8 4 0 0 4 4 4 0 Ankyrin repeat Ank PF00023.25 KOO29445.1 - 0.076 12.8 0.2 2.7 7.9 0.0 3.5 3 1 0 3 3 3 0 Ankyrin repeat Nop14 PF04147.7 KOO29446.1 - 0.0067 14.4 2.7 0.0086 14.0 1.9 1.1 1 0 0 1 1 1 1 Nop14-like family Serinc PF03348.10 KOO29447.1 - 1.2e-64 218.5 19.9 1.9e-64 217.9 13.8 1.2 1 0 0 1 1 1 1 Serine incorporator (Serinc) Abhydrolase_5 PF12695.2 KOO29448.1 - 6.1e-05 22.7 0.0 7.3e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO29448.1 - 0.003 17.4 0.1 0.0031 17.4 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ank_5 PF13857.1 KOO29449.1 - 2.7e-67 221.2 30.3 6.7e-06 26.1 0.0 19.9 8 5 14 22 22 22 18 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO29449.1 - 3.4e-62 206.7 25.7 5.8e-08 32.9 0.1 13.7 1 1 12 14 14 14 14 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO29449.1 - 7.3e-42 141.0 13.2 0.00086 19.7 0.0 15.5 10 4 7 18 18 18 12 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO29449.1 - 6.5e-40 131.1 33.8 0.18 12.1 0.0 23.3 26 0 0 26 26 26 9 Ankyrin repeat Ank PF00023.25 KOO29449.1 - 5.5e-39 130.0 39.7 0.01 15.6 0.0 23.9 25 1 0 25 25 25 12 Ankyrin repeat DUF976 PF06162.7 KOO29449.1 - 0.00012 21.5 0.0 0.9 9.0 0.0 5.3 7 1 0 8 8 8 1 Caenorhabditis elegans protein of unknown function (DUF976) DUF3349 PF11829.3 KOO29449.1 - 0.00088 19.6 0.1 9.8 6.6 0.0 6.0 4 2 1 5 5 5 1 Protein of unknown function (DUF3349) Anti-adapt_IraP PF10796.4 KOO29449.1 - 0.042 14.2 0.9 1.2 9.5 0.1 3.6 3 0 0 3 3 3 0 Sigma-S stabilisation anti-adaptor protein Nucleotid_trans PF03407.11 KOO29450.1 - 7.3e-28 97.7 0.0 1.1e-27 97.2 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase O-FucT PF10250.4 KOO29450.1 - 0.019 14.0 0.0 0.031 13.4 0.0 1.2 1 0 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase Clathrin_H_link PF13838.1 KOO29453.1 - 0.21 11.4 2.6 0.67 9.8 0.1 2.9 2 1 0 2 2 2 0 Clathrin-H-link DUF500 PF04366.7 KOO29454.1 - 6.5e-35 119.3 0.0 1e-34 118.6 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF500) FYVE PF01363.16 KOO29454.1 - 1.5e-18 66.4 7.4 2.6e-18 65.6 5.1 1.3 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.11 KOO29454.1 - 0.0045 16.8 2.1 0.0073 16.1 1.5 1.3 1 0 0 1 1 1 1 FYVE-type zinc finger DUF2797 PF10977.3 KOO29454.1 - 0.79 9.3 2.0 1.3 8.6 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) HypA PF01155.14 KOO29454.1 - 7.7 6.2 6.5 15 5.2 4.5 1.4 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Clathrin PF00637.15 KOO29455.1 - 6.6e-18 64.6 15.9 0.0068 16.0 0.0 10.6 6 2 6 12 12 12 5 Region in Clathrin and VPS WD40 PF00400.27 KOO29455.1 - 7.2e-08 32.0 7.0 0.15 11.9 0.0 6.4 6 0 0 6 6 6 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 KOO29455.1 - 6.9e-07 28.4 9.8 0.00013 20.9 0.9 5.1 5 2 0 6 6 6 2 Coatomer WD associated region TPR_19 PF14559.1 KOO29455.1 - 4.2e-05 23.8 18.8 5 7.5 0.0 9.0 8 1 1 9 9 9 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO29455.1 - 0.00038 20.8 41.7 26 5.7 0.0 15.6 13 3 2 16 16 16 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOO29455.1 - 0.0036 16.8 16.4 28 4.5 0.0 9.9 9 0 0 9 9 9 0 Tetratricopeptide repeat PPR PF01535.15 KOO29455.1 - 0.053 13.5 8.8 30 4.8 0.1 8.1 8 0 0 8 8 8 0 PPR repeat EF-hand_8 PF13833.1 KOO29455.1 - 0.058 13.0 0.1 0.74 9.4 0.1 2.7 3 0 0 3 3 3 0 EF-hand domain pair Mad3_BUB1_I PF08311.7 KOO29455.1 - 0.18 11.6 16.6 0.04 13.7 0.3 5.3 7 0 0 7 7 7 0 Mad3/BUB1 homology region 1 TPR_7 PF13176.1 KOO29455.1 - 0.19 11.6 31.0 2.8 7.9 0.3 11.5 11 3 0 11 11 10 0 Tetratricopeptide repeat TPR_11 PF13414.1 KOO29455.1 - 0.31 10.7 29.6 2 8.1 0.0 10.9 10 0 0 10 10 10 0 TPR repeat PPR_2 PF13041.1 KOO29455.1 - 0.47 10.4 1.7 16 5.5 0.0 4.4 4 0 0 4 4 4 0 PPR repeat family TPR_2 PF07719.12 KOO29455.1 - 9.1 6.4 44.4 23 5.2 0.1 13.5 16 0 0 16 16 16 0 Tetratricopeptide repeat DUF1602 PF07673.9 KOO29456.1 - 0.19 11.2 2.6 0.29 10.6 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1602) EF-hand_1 PF00036.27 KOO29458.1 - 6.6e-26 87.6 16.0 0.00023 20.2 0.0 7.5 7 0 0 7 7 7 6 EF hand EF-hand_7 PF13499.1 KOO29458.1 - 4.6e-23 81.1 4.9 1.2e-06 28.5 0.8 5.7 4 1 2 6 6 6 5 EF-hand domain pair EF-hand_6 PF13405.1 KOO29458.1 - 4.8e-23 78.9 14.7 0.012 15.4 0.0 7.7 7 0 0 7 7 7 6 EF-hand domain EF-hand_5 PF13202.1 KOO29458.1 - 5.3e-12 44.5 9.8 0.11 11.8 0.0 6.0 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.1 KOO29458.1 - 1.9e-09 36.9 11.5 0.15 11.7 0.0 6.6 6 1 1 7 7 7 3 EF-hand domain pair EF-hand_10 PF14788.1 KOO29458.1 - 0.0031 17.1 2.3 6.3 6.5 0.0 4.9 4 1 1 5 5 5 1 EF hand SPARC_Ca_bdg PF10591.4 KOO29458.1 - 0.0097 15.9 1.3 3 7.9 0.0 4.2 3 2 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_like PF09279.6 KOO29458.1 - 0.022 14.7 0.0 3.7 7.6 0.0 3.4 3 0 0 3 3 3 0 Phosphoinositide-specific phospholipase C, efhand-like IQ PF00612.22 KOO29458.1 - 0.096 12.3 0.2 0.25 11.0 0.2 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif Pkinase PF00069.20 KOO29459.1 - 1.5e-63 214.3 0.0 2.1e-63 213.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29459.1 - 2.2e-34 118.7 0.0 2.8e-34 118.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO29459.1 - 9.1e-09 34.6 0.0 1.7e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO29459.1 - 0.018 14.7 0.2 0.036 13.7 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family 7TM_GPCR_Srx PF10328.4 KOO29459.1 - 0.26 10.3 0.0 0.37 9.8 0.0 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx 2OG-FeII_Oxy_3 PF13640.1 KOO29461.1 - 1.5e-18 67.1 0.1 1.9e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO29461.1 - 8e-06 25.3 0.0 1.5e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily HAD_2 PF13419.1 KOO29462.1 - 3.3e-16 60.0 0.1 4e-16 59.7 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOO29462.1 - 3.4e-05 23.4 0.1 5.9e-05 22.7 0.1 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Na_sulph_symp PF00939.14 KOO29463.1 - 3.1e-62 210.9 8.3 1.4e-61 208.8 5.7 1.7 1 1 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.11 KOO29463.1 - 1.3e-07 30.5 21.9 3.9e-06 25.6 6.2 2.4 3 0 0 3 3 3 2 Citrate transporter DcuC PF03606.10 KOO29463.1 - 0.085 11.0 12.6 0.15 10.2 8.7 1.3 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier DUF485 PF04341.7 KOO29463.1 - 1 9.1 6.8 0.073 12.7 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF485 Phosphodiest PF01663.17 KOO29465.1 - 3.1e-06 26.7 2.0 8.9e-06 25.2 0.0 2.3 2 1 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase ATG16 PF08614.6 KOO29465.1 - 0.0043 16.9 20.0 0.0043 16.9 13.9 3.2 1 1 2 3 3 3 1 Autophagy protein 16 (ATG16) Myco_19_kDa PF05481.7 KOO29465.1 - 0.22 11.3 0.0 0.43 10.3 0.0 1.4 1 0 0 1 1 1 0 Mycobacterium 19 kDa lipoprotein antigen GAS PF13851.1 KOO29465.1 - 0.26 10.4 33.1 1.6 7.8 0.5 3.4 1 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.4 KOO29465.1 - 0.3 10.9 35.9 1.8 8.4 16.4 3.5 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tropomyosin_1 PF12718.2 KOO29465.1 - 1.1 9.0 41.0 0.018 14.8 13.2 3.5 1 1 2 3 3 3 0 Tropomyosin like DSHCT PF08148.7 KOO29466.1 - 8.5e-40 135.8 6.9 3.2e-25 88.4 0.2 3.1 2 1 1 3 3 3 2 DSHCT (NUC185) domain rRNA_proc-arch PF13234.1 KOO29466.1 - 9.2e-28 97.1 0.8 1.4e-23 83.3 0.0 2.2 1 1 0 2 2 2 2 rRNA-processing arch domain DEAD PF00270.24 KOO29466.1 - 3e-23 82.1 0.0 5.6e-23 81.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO29466.1 - 2.5e-06 27.2 0.0 8.6e-06 25.5 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO29466.1 - 0.016 15.0 0.0 0.17 11.6 0.0 2.1 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit EF-hand_7 PF13499.1 KOO29467.1 - 6.9e-11 42.1 0.5 1.1e-10 41.5 0.4 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO29467.1 - 6.4e-10 37.6 0.8 4.5e-05 22.4 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO29467.1 - 3.6e-08 32.6 0.1 0.0033 17.1 0.0 2.7 2 1 1 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 KOO29467.1 - 0.00045 19.7 1.6 0.0019 17.7 0.1 2.3 1 1 1 2 2 2 1 EF-hand domain pair ubiquitin PF00240.18 KOO29468.1 - 8.8e-35 117.9 0.4 1.1e-34 117.6 0.3 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 KOO29468.1 - 8.5e-20 70.2 0.4 1.1e-19 69.8 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ribosomal_L41 PF05162.8 KOO29468.1 - 5.4e-12 45.1 28.2 5.4e-12 45.1 19.5 1.6 2 0 0 2 2 2 1 Ribosomal protein L41 Ubiquitin_2 PF14560.1 KOO29468.1 - 1.1e-05 25.6 0.1 3.9e-05 23.8 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Telomere_Sde2 PF13019.1 KOO29468.1 - 0.00065 19.4 0.0 0.00065 19.4 0.0 1.8 1 1 1 2 2 2 1 Telomere stability and silencing Rad60-SLD_2 PF13881.1 KOO29468.1 - 0.0059 16.4 0.1 0.011 15.6 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 KOO29468.1 - 0.03 14.4 0.3 0.037 14.2 0.2 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain DUF2870 PF11069.3 KOO29468.1 - 0.033 14.2 0.5 0.059 13.4 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2870) FlgD_ig PF13860.1 KOO29468.1 - 0.11 12.1 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 FlgD Ig-like domain DUF2207 PF09972.4 KOO29468.1 - 0.19 10.2 0.6 0.2 10.2 0.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Lum_binding PF00677.12 KOO29469.1 - 5.6e-37 125.5 0.0 5.1e-18 64.7 0.0 2.2 2 0 0 2 2 2 2 Lumazine binding domain Mito_fiss_reg PF05308.6 KOO29470.1 - 0.017 14.5 0.5 0.022 14.1 0.4 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator IncA PF04156.9 KOO29471.1 - 8.6 5.9 61.1 0.7 9.4 1.2 5.3 3 1 1 5 5 5 0 IncA protein Anthrax_toxA PF03497.11 KOO29472.1 - 0.017 14.9 0.1 0.13 12.1 0.0 2.1 2 0 0 2 2 2 0 Anthrax toxin LF subunit DUF4427 PF14468.1 KOO29472.1 - 0.035 13.8 0.0 0.062 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4427) eIF2A PF08662.6 KOO29473.1 - 4.5e-67 225.5 0.0 6.1e-67 225.0 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A HEV_ORF1 PF02444.11 KOO29474.1 - 0.033 14.3 0.2 0.055 13.6 0.2 1.4 1 0 0 1 1 1 0 Hepatitis E virus ORF-2 (Putative capsid protein) YndJ PF14158.1 KOO29474.1 - 0.091 11.8 2.7 0.11 11.5 1.9 1.3 1 0 0 1 1 1 0 YndJ-like protein COPIIcoated_ERV PF07970.7 KOO29477.1 - 1.2e-25 90.4 0.1 1.8e-25 89.8 0.1 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 KOO29477.1 - 4.5e-21 74.6 0.0 1.1e-20 73.4 0.0 1.6 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Thioredoxin PF00085.15 KOO29477.1 - 6.6e-15 54.6 0.0 1.3e-14 53.7 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.1 KOO29477.1 - 0.00024 21.0 0.2 0.00071 19.5 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_8 PF13905.1 KOO29477.1 - 0.13 12.3 0.0 0.43 10.7 0.0 1.9 1 1 0 1 1 1 0 Thioredoxin-like Mannosyl_trans3 PF11051.3 KOO29478.1 - 0.065 12.5 0.0 0.22 10.8 0.0 1.7 2 0 0 2 2 2 0 Mannosyltransferase putative 2OG-FeII_Oxy_3 PF13640.1 KOO29479.1 - 0.00013 22.4 0.1 0.00025 21.5 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Peptidase_M6 PF05547.6 KOO29481.1 - 5.2 4.9 6.1 6.4 4.6 0.5 2.1 2 0 0 2 2 2 0 Immune inhibitor A peptidase M6 Pkinase PF00069.20 KOO29482.1 - 1.8e-66 223.9 0.0 2.2e-66 223.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29482.1 - 9.2e-33 113.4 0.0 1.3e-32 112.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO29482.1 - 0.00067 18.7 0.1 0.0011 18.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO29482.1 - 0.008 15.9 0.1 0.016 14.9 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family YukC PF10140.4 KOO29482.1 - 0.11 11.0 0.0 0.17 10.4 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC OmpA PF00691.15 KOO29483.1 - 0.0057 17.0 0.0 0.028 14.8 0.0 2.0 2 0 0 2 2 2 1 OmpA family Pentapeptide PF00805.17 KOO29484.1 - 1.5e-17 62.4 9.3 4.1e-09 35.4 0.1 3.5 1 1 2 3 3 3 3 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.1 KOO29484.1 - 2.2e-14 53.0 3.3 1.2e-10 40.9 1.7 2.5 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.1 KOO29484.1 - 7.1e-12 45.0 7.0 8.3e-07 28.8 4.2 2.8 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) DUF837 PF05769.6 KOO29484.1 - 0.0028 17.2 3.5 0.0039 16.7 2.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF837) Prominin PF05478.6 KOO29484.1 - 0.011 13.2 3.4 0.015 12.9 2.3 1.1 1 0 0 1 1 1 0 Prominin Mod_r PF07200.8 KOO29484.1 - 0.041 13.8 8.1 0.066 13.1 5.6 1.3 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Tmemb_cc2 PF10267.4 KOO29484.1 - 0.047 12.2 7.7 0.066 11.7 5.3 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Transposase_22 PF02994.9 KOO29484.1 - 0.061 11.8 3.6 0.083 11.3 2.5 1.1 1 0 0 1 1 1 0 L1 transposable element RPAP1_C PF08620.5 KOO29484.1 - 0.18 11.7 4.4 28 4.6 0.0 5.2 3 2 2 5 5 5 0 RPAP1-like, C-terminal HAUS-augmin3 PF14932.1 KOO29484.1 - 0.54 9.4 11.0 0.8 8.8 7.6 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Mto2_bdg PF12808.2 KOO29484.1 - 0.54 10.4 10.7 3.7 7.7 2.4 2.5 1 1 1 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF1993 PF09351.5 KOO29484.1 - 0.9 9.4 7.8 1.1 9.1 4.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF1993) KIAA1430 PF13879.1 KOO29484.1 - 0.97 9.8 6.2 4.4 7.7 1.4 2.2 1 1 1 2 2 2 0 KIAA1430 homologue AAA_13 PF13166.1 KOO29484.1 - 1.1 7.6 5.1 1.4 7.2 3.5 1.1 1 0 0 1 1 1 0 AAA domain DUF4407 PF14362.1 KOO29484.1 - 1.1 8.1 11.8 1.7 7.5 8.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FUSC PF04632.7 KOO29484.1 - 1.3 7.3 12.9 1.7 7.0 8.9 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Atg14 PF10186.4 KOO29484.1 - 2.6 6.9 12.3 3.6 6.4 8.5 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Pro_CA PF00484.14 KOO29484.1 - 3.2 7.7 9.1 1.1 9.2 4.2 1.7 2 0 0 2 2 2 0 Carbonic anhydrase DUF972 PF06156.8 KOO29484.1 - 3.4 8.0 7.4 6.5 7.1 4.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF972) Antigen_Bd37 PF11641.3 KOO29484.1 - 5.2 6.2 7.2 8.2 5.6 1.4 2.1 1 1 1 2 2 2 0 Glycosylphosphatidylinositol-anchored merozoite surface protein GXGXG PF01493.14 KOO29484.1 - 5.4 5.9 7.1 1.9 7.4 2.9 1.7 2 0 0 2 2 2 0 GXGXG motif NAP PF00956.13 KOO29485.1 - 2.7e-11 43.0 0.1 9.9e-11 41.2 0.1 1.8 1 1 0 1 1 1 1 Nucleosome assembly protein (NAP) C2 PF00168.25 KOO29485.1 - 0.0031 17.3 0.0 0.0082 15.9 0.0 1.7 1 0 0 1 1 1 1 C2 domain Reo_sigmaC PF04582.7 KOO29486.1 - 0.013 14.6 7.6 0.009 15.2 2.7 2.1 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Sec34 PF04136.10 KOO29486.1 - 1.4 8.5 7.4 0.28 10.8 1.8 2.2 2 1 0 2 2 2 0 Sec34-like family PHD PF00628.24 KOO29487.1 - 2e-13 49.7 17.9 1.9e-12 46.6 2.1 3.4 2 1 1 3 3 3 2 PHD-finger PHD_2 PF13831.1 KOO29487.1 - 0.0037 16.5 0.6 0.0037 16.5 0.4 4.0 4 1 0 4 4 4 2 PHD-finger Prok-RING_1 PF14446.1 KOO29487.1 - 0.0038 16.9 0.8 0.0038 16.9 0.5 3.6 3 2 0 3 3 3 1 Prokaryotic RING finger family 1 C1_1 PF00130.17 KOO29487.1 - 0.0069 16.0 0.1 0.0069 16.0 0.0 3.3 3 0 0 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-PHD-like PF15446.1 KOO29487.1 - 0.0088 15.3 0.1 0.0088 15.3 0.1 2.8 3 0 0 3 3 3 1 PHD/FYVE-zinc-finger like domain zf-RING_4 PF14570.1 KOO29487.1 - 0.089 12.3 0.6 0.089 12.3 0.4 3.2 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-4CXXC_R1 PF10497.4 KOO29487.1 - 0.3 11.2 8.3 0.06 13.4 2.4 2.2 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 PhnA_Zn_Ribbon PF08274.7 KOO29487.1 - 0.98 9.2 21.9 0.15 11.8 1.2 4.2 4 0 0 4 4 4 0 PhnA Zinc-Ribbon Pentapeptide PF00805.17 KOO29488.1 - 6.1e-14 50.8 3.0 1.6e-10 40.0 0.2 3.0 2 1 0 3 3 3 2 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.1 KOO29488.1 - 3.1e-12 46.1 0.1 8.5e-12 44.7 0.1 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.1 KOO29488.1 - 8.1e-12 44.8 15.4 6.9e-09 35.4 2.2 2.3 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) DUF2717 PF10911.3 KOO29488.1 - 0.016 14.7 0.2 0.068 12.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2717) Prominin PF05478.6 KOO29488.1 - 0.031 11.8 2.1 0.039 11.5 1.4 1.1 1 0 0 1 1 1 0 Prominin KIAA1430 PF13879.1 KOO29488.1 - 0.073 13.4 5.2 3.2 8.2 1.4 2.2 1 1 1 2 2 2 0 KIAA1430 homologue DUF1993 PF09351.5 KOO29488.1 - 0.1 12.5 9.2 0.048 13.5 3.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1993) Tmemb_cc2 PF10267.4 KOO29488.1 - 0.21 10.1 8.6 0.31 9.5 5.9 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein FUSC PF04632.7 KOO29488.1 - 0.45 8.8 14.1 0.59 8.4 9.8 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4407 PF14362.1 KOO29488.1 - 0.6 9.0 12.5 0.89 8.4 8.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4200 PF13863.1 KOO29488.1 - 0.82 9.6 12.2 0.8 9.6 6.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Mto2_bdg PF12808.2 KOO29488.1 - 0.83 9.8 10.5 3.4 7.8 2.5 2.6 1 1 1 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Mnd1 PF03962.10 KOO29488.1 - 0.96 9.0 8.7 1.5 8.4 6.0 1.4 1 0 0 1 1 1 0 Mnd1 family HAUS-augmin3 PF14932.1 KOO29488.1 - 1.2 8.2 10.6 1.9 7.6 7.4 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Atg14 PF10186.4 KOO29488.1 - 1.3 7.8 10.2 1.8 7.4 7.1 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Pro_CA PF00484.14 KOO29488.1 - 1.4 8.8 8.2 1.6 8.6 3.6 2.1 2 0 0 2 2 2 0 Carbonic anhydrase Antigen_Bd37 PF11641.3 KOO29488.1 - 4.9 6.3 6.2 16 4.6 1.7 2.1 1 1 1 2 2 2 0 Glycosylphosphatidylinositol-anchored merozoite surface protein Adeno_PIX PF03955.9 KOO29488.1 - 7.3 7.1 10.1 7.4 7.1 6.0 1.8 1 1 0 1 1 1 0 Adenovirus hexon-associated protein (IX) Viral_P18 PF04521.8 KOO29488.1 - 9.1 5.7 13.7 2.1 7.8 3.5 3.2 2 1 1 3 3 3 0 ssRNA positive strand viral 18kD cysteine rich protein DUF972 PF06156.8 KOO29488.1 - 9.8 6.5 8.0 10 6.4 4.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF972) PARP PF00644.15 KOO29489.1 - 0.0026 17.2 0.0 0.0026 17.2 0.0 1.1 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PALP PF00291.20 KOO29491.1 - 1.1e-20 74.1 0.1 1.6e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme SUI1 PF01253.17 KOO29492.1 - 6e-19 67.6 0.9 1.3e-18 66.5 0.7 1.5 1 0 0 1 1 1 1 Translation initiation factor SUI1 Adaptin_N PF01602.15 KOO29493.1 - 5.2e-110 368.2 0.0 6.8e-110 367.8 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.11 KOO29493.1 - 1.9e-16 60.0 0.0 4.6e-16 58.7 0.0 1.7 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.15 KOO29493.1 - 1.1e-14 54.7 0.0 2e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 Adaptin C-terminal domain Proteasom_PSMB PF10508.4 KOO29493.1 - 0.23 9.6 2.1 0.29 9.3 0.9 1.5 2 0 0 2 2 2 0 Proteasome non-ATPase 26S subunit TPT PF03151.11 KOO29494.1 - 1.8e-10 40.6 6.5 1.8e-10 40.6 4.5 1.7 2 0 0 2 2 2 1 Triose-phosphate Transporter family DUF3302 PF11742.3 KOO29494.1 - 0.16 11.8 4.4 0.19 11.6 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3302) ketoacyl-synt PF00109.21 KOO29495.1 - 5.4e-46 157.1 0.1 7.6e-46 156.6 0.0 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 KOO29495.1 - 1.7e-36 124.6 0.9 3.6e-36 123.6 0.1 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 KOO29495.1 - 0.00026 20.0 0.6 0.00069 18.6 0.2 1.8 2 0 0 2 2 2 1 Thiolase, N-terminal domain Ank PF00023.25 KOO29496.1 - 6e-12 44.7 1.4 0.004 16.9 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.2 KOO29496.1 - 1.9e-11 44.1 0.0 5.4e-11 42.6 0.0 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO29496.1 - 2.3e-07 30.3 0.1 0.14 12.5 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 KOO29496.1 - 6.9e-05 22.9 0.3 0.00024 21.2 0.1 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO29496.1 - 0.00024 21.5 0.1 0.19 12.2 0.0 3.3 1 1 2 3 3 3 2 Ankyrin repeats (many copies) CENP-C_mid PF15620.1 KOO29496.1 - 0.11 12.2 0.1 0.17 11.5 0.1 1.2 1 0 0 1 1 1 0 Centromere assembly component CENP-C middle DNMT3B-binding region HRDC PF00570.18 KOO29498.1 - 8.9e-09 34.9 0.0 2.4e-08 33.5 0.0 1.8 2 0 0 2 2 2 1 HRDC domain Transglut_core PF01841.14 KOO29499.1 - 9.2e-15 54.8 0.1 2.1e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily Transglut_core3 PF13471.1 KOO29499.1 - 0.00026 20.7 0.7 0.00026 20.7 0.5 2.4 2 1 0 2 2 2 1 Transglutaminase-like superfamily Peptidase_C25 PF01364.13 KOO29500.1 - 1.9e-33 115.9 0.3 2.4e-33 115.6 0.2 1.1 1 0 0 1 1 1 1 Peptidase family C25 Propeptide_C25 PF08126.6 KOO29500.1 - 7e-13 48.0 0.0 1.1e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 Propeptide_C25 GSH_synth_ATP PF03917.12 KOO29501.1 - 1.6e-78 263.9 0.0 2.6e-78 263.2 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.10 KOO29501.1 - 4.2e-31 107.1 0.0 7.7e-31 106.2 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Pkinase PF00069.20 KOO29502.1 - 1.5e-44 152.1 0.0 3.5e-44 150.8 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29502.1 - 9.2e-12 44.5 0.0 1.4e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO29502.1 - 1.8e-05 24.5 8.4 0.0002 21.1 0.0 3.4 2 2 2 4 4 4 2 Phosphotransferase enzyme family Choline_kinase PF01633.15 KOO29502.1 - 0.051 13.1 0.0 0.097 12.2 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase DWNN PF08783.6 KOO29503.1 - 1.1e-13 50.9 0.0 1.9e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 DWNN domain zf-C3HC4_3 PF13920.1 KOO29503.1 - 0.029 14.0 0.4 0.05 13.2 0.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) U-box PF04564.10 KOO29503.1 - 0.085 12.8 0.0 0.26 11.2 0.0 1.9 1 1 0 1 1 1 0 U-box domain Sybindin PF04099.7 KOO29504.1 - 1.2e-31 109.3 0.0 1.3e-31 109.2 0.0 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.8 KOO29504.1 - 4.9e-07 29.6 0.0 3.3e-06 27.0 0.0 1.9 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region WD40 PF00400.27 KOO29505.1 - 1.3e-86 281.6 18.2 4e-11 42.3 0.1 8.2 8 0 0 8 8 8 8 WD domain, G-beta repeat NLE PF08154.7 KOO29505.1 - 1.1e-16 60.6 0.1 1.7e-16 59.9 0.1 1.3 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.3 KOO29505.1 - 3.4e-08 32.1 2.4 0.013 13.7 0.1 3.4 3 1 0 3 3 3 3 Nucleoporin Nup120/160 Gmad1 PF10647.4 KOO29505.1 - 0.00043 19.7 0.7 0.00043 19.7 0.5 3.0 3 1 1 4 4 4 1 Lipoprotein LpqB beta-propeller domain Nbas_N PF15492.1 KOO29505.1 - 0.014 14.5 0.3 20 4.1 0.0 3.7 2 1 2 4 4 4 0 Neuroblastoma-amplified sequence, N terminal IKI3 PF04762.7 KOO29505.1 - 0.019 12.8 0.1 0.036 11.8 0.1 1.4 1 1 0 1 1 1 0 IKI3 family Nucleoporin_N PF08801.6 KOO29505.1 - 0.027 13.2 0.1 3.3 6.3 0.0 3.0 3 0 0 3 3 3 0 Nup133 N terminal like PD40 PF07676.7 KOO29505.1 - 0.034 13.8 1.8 40 4.0 0.0 4.2 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat DUF3312 PF11768.3 KOO29505.1 - 0.053 11.7 0.0 0.2 9.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3312) CENP-X PF09415.5 KOO29506.1 - 0.022 14.5 1.1 0.043 13.6 0.8 1.4 1 0 0 1 1 1 0 CENP-S associating Centromere protein X DUF3896 PF13035.1 KOO29506.1 - 0.11 12.6 1.1 0.19 11.8 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3896) TAT_signal PF10518.4 KOO29506.1 - 2 8.6 7.7 0.23 11.5 2.2 1.9 2 0 0 2 2 2 0 TAT (twin-arginine translocation) pathway signal sequence Mnd1 PF03962.10 KOO29506.1 - 2.2 7.8 7.5 1 8.9 3.7 1.5 2 0 0 2 2 2 0 Mnd1 family DUF4407 PF14362.1 KOO29506.1 - 2.8 6.8 9.8 3.6 6.4 6.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CPSF_A PF03178.10 KOO29508.1 - 1.1e-74 251.4 0.0 1.9e-74 250.6 0.0 1.4 1 0 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.4 KOO29508.1 - 4.7e-70 236.1 0.0 6.9e-70 235.6 0.0 1.1 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term cobW PF02492.14 KOO29510.1 - 2.3e-53 180.2 0.1 2.9e-53 179.9 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 KOO29510.1 - 2.5e-18 65.5 0.0 4.4e-18 64.7 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain MMR_HSR1 PF01926.18 KOO29510.1 - 0.00011 22.1 0.0 0.00018 21.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase UPF0079 PF02367.12 KOO29510.1 - 0.013 15.0 0.1 0.033 13.8 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 GTP_EFTU PF00009.22 KOO29510.1 - 0.015 14.7 0.6 0.18 11.2 0.4 2.1 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.1 KOO29510.1 - 0.016 15.1 0.1 0.029 14.3 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.1 KOO29510.1 - 0.019 15.3 0.3 0.026 14.8 0.2 1.4 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.1 KOO29510.1 - 0.023 14.2 0.1 0.055 13.0 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.1 KOO29510.1 - 0.03 14.0 0.3 0.063 13.0 0.2 1.4 1 0 0 1 1 1 0 Part of AAA domain DUF258 PF03193.11 KOO29510.1 - 0.032 13.4 0.0 0.055 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Arch_ATPase PF01637.13 KOO29510.1 - 0.039 13.6 0.0 0.078 12.6 0.0 1.6 1 0 0 1 1 1 0 Archaeal ATPase AAA_28 PF13521.1 KOO29510.1 - 0.044 13.7 1.3 0.31 11.0 0.9 2.4 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.1 KOO29510.1 - 0.044 13.6 0.0 0.087 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.1 KOO29510.1 - 0.085 12.9 0.0 0.2 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 KOO29510.1 - 0.096 11.7 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin MobB PF03205.9 KOO29510.1 - 0.12 12.0 0.0 0.27 10.9 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 KOO29510.1 - 0.12 11.7 0.5 0.56 9.5 0.1 2.0 1 1 0 2 2 2 0 AAA-like domain ABC_tran PF00005.22 KOO29510.1 - 0.13 12.5 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.1 KOO29510.1 - 0.17 12.2 1.6 0.62 10.3 0.8 2.4 1 1 0 1 1 1 0 AAA domain AAA PF00004.24 KOO29513.1 - 3.1e-59 198.8 0.0 9.6e-33 113.1 0.0 3.1 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KOO29513.1 - 7.9e-06 25.6 0.1 0.00031 20.4 0.0 2.9 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOO29513.1 - 7.9e-06 25.9 5.5 0.00023 21.1 0.1 3.9 3 1 1 4 4 4 1 AAA ATPase domain AAA_17 PF13207.1 KOO29513.1 - 2.7e-05 24.9 0.0 6.9e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 KOO29513.1 - 5.3e-05 22.3 0.1 0.00021 20.3 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KOO29513.1 - 0.00024 21.2 0.1 0.029 14.5 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KOO29513.1 - 0.00047 19.8 0.2 0.00047 19.8 0.1 3.5 3 0 0 3 3 3 1 Part of AAA domain AAA_33 PF13671.1 KOO29513.1 - 0.00054 19.8 0.0 0.0015 18.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 KOO29513.1 - 0.011 14.9 0.2 0.04 13.0 0.1 1.8 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.12 KOO29513.1 - 0.018 14.4 0.0 0.035 13.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_2 PF07724.9 KOO29513.1 - 0.021 14.7 0.0 5.7 6.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) NACHT PF05729.7 KOO29513.1 - 0.026 14.1 0.0 0.95 9.0 0.0 3.0 2 1 1 3 3 3 0 NACHT domain Sigma54_activat PF00158.21 KOO29513.1 - 0.1 12.0 0.0 0.92 8.9 0.0 2.5 2 1 0 2 2 2 0 Sigma-54 interaction domain TIP49 PF06068.8 KOO29513.1 - 0.27 9.9 0.0 0.44 9.2 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus Bin3 PF06859.7 KOO29514.1 - 3.3e-09 36.7 0.0 7.6e-09 35.5 0.0 1.6 1 0 0 1 1 1 1 Bicoid-interacting protein 3 (Bin3) Opi1 PF08618.5 KOO29514.1 - 0.2 10.5 5.5 0.27 10.1 3.8 1.2 1 0 0 1 1 1 0 Transcription factor Opi1 CMV_1a PF12467.3 KOO29514.1 - 0.29 11.4 5.9 0.35 11.2 1.2 2.1 2 0 0 2 2 2 0 Cucumber mosaic virus 1a protein family RRP14 PF15459.1 KOO29514.1 - 0.67 10.0 13.7 0.24 11.4 2.8 2.4 2 0 0 2 2 2 0 60S ribosome biogenesis protein Rrp14 Herpes_capsid PF06112.6 KOO29514.1 - 2.6 8.0 10.4 0.39 10.7 4.5 1.6 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein Tombus_movement PF05318.7 KOO29514.1 - 5.7 7.6 8.4 16 6.2 0.2 2.5 2 0 0 2 2 2 0 Tombusvirus movement protein ABC1 PF03109.11 KOO29515.1 - 2.6e-21 75.8 0.0 1e-20 73.8 0.0 1.9 2 0 0 2 2 2 1 ABC1 family APH PF01636.18 KOO29515.1 - 1.6e-05 24.8 0.5 1.6e-05 24.8 0.4 3.3 4 1 0 4 4 4 1 Phosphotransferase enzyme family RIO1 PF01163.17 KOO29515.1 - 8.3e-05 22.0 0.0 0.00097 18.5 0.0 2.2 2 0 0 2 2 2 1 RIO1 family Pkinase PF00069.20 KOO29515.1 - 0.058 12.5 0.0 0.2 10.7 0.0 1.7 2 0 0 2 2 2 0 Protein kinase domain Bacteriocin_IIc PF10439.4 KOO29516.1 - 1.8 8.7 6.9 2.8 8.1 4.8 1.2 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide LRR_5 PF13306.1 KOO29517.1 - 1.1e-116 384.0 0.0 4.5e-36 123.3 0.0 4.2 1 1 3 4 4 4 4 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO29517.1 - 5.6e-35 118.8 0.0 4.1e-06 26.4 0.0 9.4 3 2 10 13 13 13 12 Leucine rich repeat Skp1 PF01466.14 KOO29517.1 - 0.069 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Skp1 family, dimerisation domain DUF2240 PF09999.4 KOO29517.1 - 0.29 10.5 0.0 14 5.0 0.0 2.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2240) Tox-ODYAM1 PF15642.1 KOO29518.1 - 1.8 7.1 13.2 0.058 12.0 4.6 1.7 1 1 1 2 2 2 0 Toxin in Odyssella and Amoebophilus DUF1318 PF07027.7 KOO29518.1 - 2.5 8.4 6.8 5.6 7.2 2.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1318) Cytidylate_kin2 PF13189.1 KOO29518.1 - 3.8 7.3 9.6 20 5.0 6.6 2.0 1 1 0 1 1 1 0 Cytidylate kinase-like family SLAIN PF15301.1 KOO29520.1 - 0.054 12.6 3.4 0.067 12.3 2.3 1.1 1 0 0 1 1 1 0 SLAIN motif-containing family DUF221 PF02714.10 KOO29521.1 - 0.00031 19.6 13.0 0.0067 15.3 9.0 2.6 1 1 0 1 1 1 1 Domain of unknown function DUF221 ATPgrasp_ST PF14397.1 KOO29524.1 - 0.00038 19.6 0.0 0.00054 19.1 0.0 1.2 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp tRNA_U5-meth_tr PF05958.6 KOO29525.1 - 2.1e-115 385.2 0.0 2.4e-115 385.0 0.0 1.0 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_18 PF12847.2 KOO29525.1 - 3.5e-05 24.3 0.0 6.1e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO29525.1 - 7.8e-05 22.3 0.0 0.00014 21.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO29525.1 - 0.00022 21.2 0.1 0.00063 19.7 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOO29525.1 - 0.0003 20.1 0.1 0.00076 18.8 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.12 KOO29525.1 - 0.00045 19.3 0.0 0.00072 18.6 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Met_10 PF02475.11 KOO29525.1 - 0.0097 15.5 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_15 PF09445.5 KOO29525.1 - 0.067 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase DUF2666 PF10869.3 KOO29526.1 - 0.0066 16.4 0.1 0.0097 15.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2666) PCP_red PF08369.5 KOO29526.1 - 0.052 13.4 2.3 0.11 12.3 0.6 2.3 2 1 0 2 2 2 0 Proto-chlorophyllide reductase 57 kD subunit PqiA PF04403.8 KOO29527.1 - 5.9e-08 32.4 3.0 5.9e-08 32.4 2.1 3.2 4 0 0 4 4 4 2 Paraquat-inducible protein A IBR PF01485.16 KOO29528.1 - 1.2e-13 50.7 46.9 8.7e-11 41.5 4.7 4.4 3 1 1 4 4 4 2 IBR domain zf-C3HC4_2 PF13923.1 KOO29528.1 - 0.00018 21.4 8.4 0.00018 21.4 5.8 3.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO29528.1 - 0.00057 19.5 8.8 0.00057 19.5 6.1 3.7 3 1 0 3 3 3 1 zinc-RING finger domain zf-C3HC4 PF00097.20 KOO29528.1 - 0.0011 18.5 5.1 0.0011 18.5 3.6 3.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO29528.1 - 0.0022 17.7 8.0 0.0022 17.7 5.5 3.6 3 0 0 3 3 3 1 Ring finger domain Kinesin PF00225.18 KOO29529.1 - 6.4e-87 291.3 0.0 1.2e-86 290.4 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Syntaxin-18_N PF10496.4 KOO29529.1 - 0.017 14.9 0.2 8.9 6.2 0.0 2.5 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus DUF972 PF06156.8 KOO29529.1 - 0.57 10.5 7.9 0.24 11.7 3.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF972) DASH_Spc19 PF08287.6 KOO29529.1 - 0.61 9.6 10.3 0.61 9.6 5.7 2.0 1 1 0 1 1 1 0 Spc19 DDRGK PF09756.4 KOO29530.1 - 5.2e-49 166.2 15.3 6.2e-49 165.9 10.6 1.1 1 0 0 1 1 1 1 DDRGK domain FeoC PF09012.5 KOO29530.1 - 3.5e-05 23.4 0.3 0.0054 16.3 0.0 2.4 2 0 0 2 2 2 1 FeoC like transcriptional regulator DHQS PF01959.11 KOO29530.1 - 0.049 12.3 6.2 0.061 12.0 4.3 1.1 1 0 0 1 1 1 0 3-dehydroquinate synthase (EC 4.6.1.3) RPA_C PF08784.6 KOO29530.1 - 0.055 13.8 0.1 0.088 13.2 0.0 1.5 1 1 0 1 1 1 0 Replication protein A C terminal NA37 PF04245.8 KOO29530.1 - 0.34 10.2 9.3 0.52 9.5 6.4 1.2 1 0 0 1 1 1 0 37-kD nucleoid-associated bacterial protein DUF3347 PF11827.3 KOO29530.1 - 1 9.3 7.2 1.4 8.8 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) CAF-1_p150 PF11600.3 KOO29530.1 - 1.1 8.5 19.3 1.6 8.0 13.4 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal PTEN_C2 PF10409.4 KOO29531.1 - 2.7e-17 62.7 0.4 8.5e-10 38.4 0.1 3.3 3 0 0 3 3 3 3 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.15 KOO29531.1 - 1.2e-15 57.3 0.1 1e-07 31.5 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KOO29531.1 - 8.7e-13 48.1 0.0 8.1e-06 25.3 0.0 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 KOO29531.1 - 2.3e-10 40.9 0.0 0.00041 20.6 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.1 KOO29531.1 - 6.1e-07 29.5 0.1 0.011 15.7 0.0 2.3 2 0 0 2 2 2 2 Inositol hexakisphosphate Y_phosphatase2 PF03162.8 KOO29531.1 - 0.00056 19.3 0.0 0.58 9.4 0.0 2.5 2 0 0 2 2 2 2 Tyrosine phosphatase family RXT2_N PF08595.6 KOO29531.1 - 0.2 11.4 0.1 0.36 10.6 0.1 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal XET_C PF06955.7 KOO29531.1 - 0.84 9.3 4.6 17 5.2 0.3 2.5 2 0 0 2 2 2 0 Xyloglucan endo-transglycosylase (XET) C-terminus DUF1049 PF06305.6 KOO29533.1 - 0.019 14.4 1.0 0.019 14.4 0.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) Flu_M1_C PF08289.6 KOO29533.1 - 1.2 9.2 5.6 2.5 8.2 3.7 1.6 1 1 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain Abhydrolase_6 PF12697.2 KOO29534.1 - 1.4e-18 67.6 1.0 2.3e-08 34.1 0.1 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO29534.1 - 1.1e-10 41.5 0.0 2.7e-05 23.8 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 KOO29534.1 - 1.1e-07 31.7 0.0 7.8e-05 22.4 0.0 2.3 1 1 1 2 2 2 2 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 KOO29534.1 - 0.0097 15.7 0.1 0.017 14.9 0.1 1.5 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_4 PF08386.5 KOO29534.1 - 0.12 12.3 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein Pro_CA PF00484.14 KOO29535.1 - 4.6e-41 140.3 0.4 7.2e-41 139.7 0.2 1.3 1 0 0 1 1 1 1 Carbonic anhydrase Pkinase PF00069.20 KOO29536.1 - 2e-47 161.5 0.0 2.8e-47 161.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29536.1 - 1.4e-39 135.7 0.0 2.3e-39 135.0 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO29536.1 - 0.0042 16.0 0.0 0.0069 15.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO29536.1 - 0.015 15.0 0.4 0.079 12.6 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF2217 PF10265.4 KOO29536.1 - 0.017 13.8 0.0 0.03 13.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) Dynein_heavy PF03028.10 KOO29537.1 - 2.9e-224 746.2 0.0 6.8e-224 745.0 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DHC_N2 PF08393.8 KOO29537.1 - 1.5e-128 428.8 6.1 1.5e-128 428.8 4.2 3.5 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.7 KOO29537.1 - 3.3e-127 425.3 0.1 3.3e-127 425.3 0.1 2.6 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.2 KOO29537.1 - 1.8e-101 338.4 0.3 3.8e-101 337.4 0.2 1.6 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.2 KOO29537.1 - 5.4e-78 261.6 0.1 1.4e-77 260.2 0.0 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 KOO29537.1 - 3.6e-60 202.6 0.5 7.2e-60 201.6 0.3 1.5 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 MT PF12777.2 KOO29537.1 - 1.2e-53 182.1 16.4 2.5e-53 181.0 11.4 1.6 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 KOO29537.1 - 6.6e-52 176.2 0.0 1.6e-51 175.0 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_5 PF07728.9 KOO29537.1 - 3.8e-20 72.0 0.0 6.3e-05 22.7 0.0 5.8 5 1 0 5 5 5 4 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 KOO29537.1 - 3.8e-06 27.0 0.1 0.73 9.9 0.0 5.0 5 0 0 5 5 4 2 AAA domain AAA_16 PF13191.1 KOO29537.1 - 5.7e-06 26.4 0.3 3 7.7 0.0 5.5 4 0 0 4 4 4 2 AAA ATPase domain AAA_25 PF13481.1 KOO29537.1 - 0.00021 20.7 0.3 0.36 10.1 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA PF00004.24 KOO29537.1 - 0.003 17.7 4.0 4.4 7.5 0.1 4.8 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 KOO29537.1 - 0.03 15.1 0.1 5.5 7.8 0.0 4.3 4 0 0 4 4 3 0 AAA domain DUF258 PF03193.11 KOO29537.1 - 0.19 10.9 0.3 5.4 6.1 0.0 2.9 3 0 0 3 3 2 0 Protein of unknown function, DUF258 ATP-synt_ab PF00006.20 KOO29537.1 - 0.25 10.8 0.0 32 3.9 0.0 3.7 3 1 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_19 PF13245.1 KOO29537.1 - 0.39 10.4 2.2 11 5.9 0.2 3.1 2 0 0 2 2 2 0 Part of AAA domain Pro-rich PF15240.1 KOO29537.1 - 2.3 8.2 23.9 4.3 7.4 16.5 1.3 1 0 0 1 1 1 0 Proline-rich EF-hand_1 PF00036.27 KOO29538.1 - 3.2e-52 169.8 1.8 1.9e-05 23.6 0.0 10.1 8 2 2 10 10 10 9 EF hand EF-hand_6 PF13405.1 KOO29538.1 - 1.3e-43 142.9 20.8 2.2e-06 27.0 0.0 10.3 6 4 4 10 10 10 8 EF-hand domain EF-hand_7 PF13499.1 KOO29538.1 - 1.6e-43 146.6 7.4 3.7e-10 39.7 0.0 5.4 3 2 2 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.1 KOO29538.1 - 5.4e-34 114.0 21.3 2.4e-05 23.4 0.0 9.0 9 1 1 10 10 10 8 EF hand EF-hand_8 PF13833.1 KOO29538.1 - 1.5e-28 98.1 10.7 9.9e-07 28.2 0.0 8.2 5 4 4 9 9 9 9 EF-hand domain pair EF-hand_10 PF14788.1 KOO29538.1 - 1.1e-07 31.3 0.0 0.12 12.0 0.0 5.5 5 1 1 6 6 6 2 EF hand Caleosin PF05042.8 KOO29538.1 - 1.6e-06 27.7 0.0 1.9 8.0 0.0 4.2 2 2 0 4 4 4 3 Caleosin related protein EF-hand_9 PF14658.1 KOO29538.1 - 0.00026 20.8 0.1 5.2 7.0 0.0 4.6 5 0 0 5 5 5 1 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO29538.1 - 0.017 15.1 0.4 3 7.8 0.0 4.1 5 1 0 5 5 5 0 Secreted protein acidic and rich in cysteine Ca binding region Lge1 PF11488.3 KOO29538.1 - 0.45 10.7 2.8 0.68 10.1 1.2 1.8 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 U-box PF04564.10 KOO29539.1 - 9e-23 80.0 0.1 3.8e-10 39.5 0.0 2.4 2 0 0 2 2 2 2 U-box domain Ank_2 PF12796.2 KOO29539.1 - 1.9e-17 63.3 6.9 1.9e-09 37.7 0.2 2.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO29539.1 - 4.4e-11 42.0 2.5 1.7e-06 27.5 0.1 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.1 KOO29539.1 - 6e-10 39.0 0.1 1.2e-05 25.3 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) zf-Nse PF11789.3 KOO29539.1 - 2.1e-08 33.5 0.0 0.0029 17.0 0.0 2.5 2 0 0 2 2 2 2 Zinc-finger of the MIZ type in Nse subunit Ank_3 PF13606.1 KOO29539.1 - 0.0003 20.7 0.2 0.13 12.5 0.0 3.7 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.1 KOO29539.1 - 0.0045 17.4 0.5 0.24 11.9 0.0 2.6 1 1 2 3 3 3 2 Ankyrin repeats (many copies) YdfZ PF14001.1 KOO29539.1 - 0.02 15.1 0.4 0.97 9.7 0.0 2.7 2 0 0 2 2 2 0 YdfZ protein DUF2680 PF10925.3 KOO29539.1 - 0.057 13.2 0.1 3.6 7.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2680) Glyco_hydro_59 PF02057.10 KOO29540.1 - 4.1e-152 507.6 0.0 5.5e-152 507.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 Glyco_hydro_30 PF02055.11 KOO29540.1 - 0.034 12.3 0.6 0.059 11.5 0.0 1.7 2 0 0 2 2 2 0 O-Glycosyl hydrolase family 30 Ank PF00023.25 KOO29542.1 - 0.11 12.4 0.0 0.19 11.6 0.0 1.5 1 1 0 1 1 1 0 Ankyrin repeat DUF3589 PF12141.3 KOO29543.1 - 0.00048 18.4 0.0 0.00068 17.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3589) DUF1777 PF08648.7 KOO29543.1 - 3.1 7.4 11.0 0.087 12.5 3.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1777) Exostosin PF03016.10 KOO29544.1 - 3.4e-08 32.8 0.0 0.00017 20.7 0.0 2.4 2 0 0 2 2 2 2 Exostosin family EF-hand_7 PF13499.1 KOO29545.1 - 2.3e-16 59.6 7.7 1.3e-05 25.2 0.1 6.0 3 2 1 5 5 5 5 EF-hand domain pair EF-hand_6 PF13405.1 KOO29545.1 - 1.2e-15 55.9 6.4 0.0011 18.6 0.1 6.7 6 0 0 6 6 6 5 EF-hand domain EF-hand_1 PF00036.27 KOO29545.1 - 1.5e-13 48.9 6.4 0.0075 15.5 0.0 6.5 6 0 0 6 6 6 4 EF hand EF-hand_5 PF13202.1 KOO29545.1 - 4.9e-07 28.7 8.9 0.00042 19.5 0.0 5.0 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.1 KOO29545.1 - 1e-05 25.0 8.5 0.13 11.9 0.0 6.0 6 1 0 6 6 6 1 EF-hand domain pair CBFD_NFYB_HMF PF00808.18 KOO29546.1 - 7.2e-06 25.9 0.0 1.1e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TMF_TATA_bd PF12325.3 KOO29546.1 - 0.032 13.9 0.4 0.057 13.1 0.3 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding ATG16 PF08614.6 KOO29546.1 - 0.12 12.1 0.7 0.16 11.7 0.5 1.2 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) His_Phos_1 PF00300.17 KOO29547.1 - 5.2e-09 36.3 0.0 9e-09 35.6 0.0 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Na_Ca_ex PF01699.19 KOO29548.1 - 5.8e-33 113.4 16.3 2.8e-19 69.0 3.7 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein EF-hand_1 PF00036.27 KOO29549.1 - 1e-09 36.9 0.1 0.00094 18.3 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO29549.1 - 1.2e-08 34.9 0.1 2.6e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO29549.1 - 1.6e-06 27.5 0.2 0.0039 16.9 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain LETM1 PF07766.8 KOO29549.1 - 6.1e-06 25.4 0.1 1.1e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 LETM1-like protein EF-hand_8 PF13833.1 KOO29549.1 - 0.00015 21.3 0.6 0.1 12.2 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO29549.1 - 0.072 12.4 0.5 0.94 8.9 0.1 2.4 2 0 0 2 2 2 0 EF hand DUF4116 PF13475.1 KOO29550.1 - 3.9e-55 183.1 0.0 5.4e-15 54.6 0.0 5.3 2 2 2 5 5 5 4 Domain of unknown function (DUF4116) EF-hand_1 PF00036.27 KOO29550.1 - 4.6e-16 56.8 0.6 3.1e-07 29.2 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 KOO29550.1 - 9e-13 48.1 0.0 2.3e-12 46.8 0.0 1.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO29550.1 - 1.8e-12 46.6 1.4 1.6e-11 43.6 0.1 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO29550.1 - 1.8e-11 42.8 0.1 1.5e-05 24.4 0.0 2.8 3 0 0 3 3 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO29550.1 - 3.6e-09 35.5 3.8 9.3e-05 21.6 0.0 3.3 3 1 0 3 3 3 2 EF hand EF-hand_9 PF14658.1 KOO29550.1 - 0.00015 21.5 0.0 0.00027 20.7 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain DUF1667 PF07892.6 KOO29550.1 - 0.0045 16.6 0.0 27 4.5 0.0 3.9 2 1 3 5 5 5 0 Protein of unknown function (DUF1667) EF-hand_4 PF12763.2 KOO29550.1 - 0.0067 16.1 0.0 0.014 15.0 0.0 1.5 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand Rsbr_N PF08678.5 KOO29550.1 - 0.026 14.3 0.0 23 4.8 0.0 3.6 1 1 3 4 4 4 0 Rsbr N terminal SPARC_Ca_bdg PF10591.4 KOO29550.1 - 0.17 11.9 0.0 0.41 10.6 0.0 1.6 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region p25-alpha PF05517.7 KOO29551.1 - 0.066 13.4 0.0 1.2 9.4 0.0 2.2 2 0 0 2 2 2 0 p25-alpha Bestrophin PF01062.16 KOO29552.1 - 1.5e-48 165.2 0.9 1.9e-48 164.9 0.6 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel DUF2568 PF10823.3 KOO29552.1 - 0.2 11.9 3.2 0.13 12.4 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2568) STAS_2 PF13466.1 KOO29553.1 - 0.093 12.7 1.1 0.69 9.9 0.2 2.3 2 0 0 2 2 2 0 STAS domain Sugar_tr PF00083.19 KOO29553.1 - 0.095 11.2 0.4 0.13 10.7 0.3 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter PRRSV_2b PF07069.6 KOO29553.1 - 0.47 10.7 2.4 0.98 9.7 1.6 1.5 1 0 0 1 1 1 0 Porcine reproductive and respiratory syndrome virus 2b 7tm_3 PF00003.17 KOO29554.1 - 0.0095 15.3 2.7 0.013 14.8 1.9 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR G3P_acyltransf PF02660.10 KOO29554.1 - 0.14 11.7 5.9 0.17 11.4 4.1 1.1 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase DUF347 PF03988.7 KOO29554.1 - 0.31 10.9 4.8 1.6 8.6 3.3 2.2 1 1 0 1 1 1 0 Repeat of Unknown Function (DUF347) DUF3533 PF12051.3 KOO29554.1 - 0.61 8.7 4.6 0.73 8.5 3.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) MatE PF01554.13 KOO29555.1 - 0.0021 17.7 4.7 0.0021 17.7 3.3 2.1 1 1 0 2 2 2 1 MatE zf-DHHC PF01529.15 KOO29555.1 - 1.1 8.6 7.8 0.2 11.0 0.1 2.4 2 1 0 2 2 2 0 DHHC palmitoyltransferase FAD_binding_6 PF00970.19 KOO29556.1 - 8.6e-20 70.7 0.0 1.9e-19 69.6 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Pkinase PF00069.20 KOO29557.1 - 1.1e-46 159.0 0.0 1.3e-46 158.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29557.1 - 2.4e-31 108.7 0.1 2.7e-31 108.5 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO29557.1 - 7.6e-05 21.8 0.0 0.00011 21.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO29557.1 - 0.11 12.1 0.5 2.4 7.8 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Adap_comp_sub PF00928.16 KOO29558.1 - 8.5e-13 47.9 0.0 1.4e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 KOO29558.1 - 1.4e-07 31.2 0.2 2.5e-07 30.5 0.1 1.4 1 1 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.4 KOO29558.1 - 0.0026 16.9 0.0 0.0049 16.1 0.0 1.4 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain AP-5_subunit_s1 PF15001.1 KOO29558.1 - 0.087 12.7 0.1 0.087 12.7 0.0 2.0 1 1 1 2 2 2 0 AP-5 complex subunit sigma-1 PTPLA PF04387.9 KOO29560.1 - 2e-05 24.0 0.4 0.078 12.4 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine phosphatase-like protein, PTPLA Malic_M PF03949.10 KOO29560.1 - 0.1 12.1 0.0 13 5.2 0.0 2.3 2 0 0 2 2 2 0 Malic enzyme, NAD binding domain MMR_HSR1 PF01926.18 KOO29562.1 - 1.3e-20 73.4 0.0 2.2e-20 72.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP1_OBG PF01018.17 KOO29562.1 - 6.2e-12 45.4 0.2 1e-11 44.7 0.1 1.4 1 0 0 1 1 1 1 GTP1/OBG FeoB_N PF02421.13 KOO29562.1 - 1.7e-06 27.4 0.0 5.2e-06 25.8 0.0 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B PduV-EutP PF10662.4 KOO29562.1 - 0.005 16.3 0.0 0.03 13.7 0.0 1.9 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Miro PF08477.8 KOO29562.1 - 0.0075 16.7 0.0 0.034 14.6 0.0 2.0 1 1 0 1 1 1 1 Miro-like protein Dynamin_N PF00350.18 KOO29562.1 - 0.073 12.8 0.0 1.4 8.7 0.0 2.2 1 1 1 2 2 2 0 Dynamin family DnaJ PF00226.26 KOO29563.1 - 2.6e-16 59.0 0.2 1.6e-15 56.5 0.0 2.5 3 0 0 3 3 3 1 DnaJ domain TPR_19 PF14559.1 KOO29563.1 - 0.051 13.9 0.7 0.21 11.9 0.5 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat PP2C PF00481.16 KOO29564.1 - 2e-35 122.4 0.0 3e-35 121.8 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 KOO29564.1 - 9.4e-07 28.4 0.3 1.3e-05 24.7 0.1 2.4 1 1 0 1 1 1 1 Protein phosphatase 2C VitK2_biosynth PF02621.9 KOO29564.1 - 0.0092 15.2 0.1 0.016 14.4 0.0 1.3 1 0 0 1 1 1 1 Menaquinone biosynthesis Toxin_28 PF08115.6 KOO29564.1 - 0.19 11.3 0.4 0.9 9.2 0.0 2.2 2 0 0 2 2 2 0 SFI toxin family UPF0004 PF00919.15 KOO29565.1 - 3.3e-29 100.5 0.1 1e-28 98.9 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized protein family UPF0004 Radical_SAM PF04055.16 KOO29565.1 - 8.3e-21 74.8 0.0 1.8e-20 73.7 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily WD40 PF00400.27 KOO29566.1 - 5.7e-30 102.0 18.8 1.4e-08 34.3 0.4 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat Sof1 PF04158.9 KOO29566.1 - 2.8e-22 78.5 9.2 4.9e-22 77.7 6.4 1.4 1 0 0 1 1 1 1 Sof1-like domain Kinesin PF00225.18 KOO29567.1 - 2e-129 431.1 8.6 3.8e-107 357.8 0.5 4.0 4 0 0 4 4 4 2 Kinesin motor domain TPR_7 PF13176.1 KOO29567.1 - 0.00025 20.6 0.2 0.026 14.2 0.1 3.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.1 KOO29567.1 - 0.00083 19.2 1.1 0.052 13.5 0.3 3.6 2 0 0 2 2 2 1 Tetratricopeptide repeat PAS_9 PF13426.1 KOO29568.1 - 9.3e-13 48.4 0.0 1.8e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 PAS domain PAS PF00989.19 KOO29568.1 - 0.0032 17.2 0.0 0.0054 16.4 0.0 1.4 1 0 0 1 1 1 1 PAS fold KorB_C PF06613.6 KOO29568.1 - 0.11 11.9 0.0 0.25 10.8 0.0 1.6 1 0 0 1 1 1 0 KorB C-terminal beta-barrel domain Myb_DNA-binding PF00249.26 KOO29569.1 - 0.033 14.2 0.4 0.11 12.5 0.3 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO29569.1 - 0.043 13.9 0.0 0.086 12.9 0.0 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain Ank_2 PF12796.2 KOO29570.1 - 1.2e-21 76.8 0.5 8.5e-15 54.8 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO29570.1 - 2.7e-20 71.0 1.6 0.00014 21.5 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 KOO29570.1 - 9.2e-13 47.9 3.1 4.2e-06 26.8 0.3 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO29570.1 - 3.7e-12 45.2 0.1 0.0049 16.9 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 KOO29570.1 - 1.8e-09 37.8 0.1 2.9e-06 27.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Nucleotid_trans PF03407.11 KOO29571.1 - 1.7e-31 109.6 0.0 2.5e-31 109.1 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase ECH PF00378.15 KOO29572.1 - 1.3e-106 355.1 18.9 3.3e-53 180.3 3.8 2.4 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase family 3HCDH_N PF02737.13 KOO29572.1 - 5.2e-67 224.9 1.7 2.2e-52 177.3 0.3 3.5 5 0 0 5 5 3 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain EF-hand_1 PF00036.27 KOO29572.1 - 4.4e-33 110.0 0.6 5.7e-06 25.2 0.1 6.6 6 0 0 6 6 6 5 EF hand EF-hand_6 PF13405.1 KOO29572.1 - 6.4e-29 97.2 3.4 1.9e-06 27.2 0.1 6.7 6 0 0 6 6 6 5 EF-hand domain EF-hand_7 PF13499.1 KOO29572.1 - 2.6e-28 97.9 0.4 8.8e-10 38.5 0.1 4.5 4 1 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO29572.1 - 4.1e-26 89.1 6.6 4.3e-06 25.8 0.1 6.0 6 0 0 6 6 6 5 EF hand 3HCDH PF00725.17 KOO29572.1 - 1.9e-25 89.0 0.1 6.3e-20 71.3 0.0 3.5 3 0 0 3 3 3 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain EF-hand_8 PF13833.1 KOO29572.1 - 6.1e-21 73.7 4.4 9.2e-05 21.9 0.0 5.8 5 0 0 5 5 5 5 EF-hand domain pair NAD_binding_8 PF13450.1 KOO29572.1 - 5.5e-06 26.3 2.5 0.14 12.1 0.1 3.4 3 0 0 3 3 3 2 NAD(P)-binding Rossmann-like domain DUF3798 PF12683.2 KOO29572.1 - 7.1e-05 22.0 9.2 0.041 12.9 0.9 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF3798) NAD_Gly3P_dh_N PF01210.18 KOO29572.1 - 0.00028 20.6 0.1 0.57 9.8 0.0 3.0 2 0 0 2 2 2 2 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Cyclophil_like PF04126.8 KOO29572.1 - 0.00056 19.4 0.0 2 8.0 0.0 2.9 2 0 0 2 2 2 2 Cyclophilin-like DAO PF01266.19 KOO29572.1 - 0.00072 18.5 5.3 0.23 10.3 0.2 2.5 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_2 PF03446.10 KOO29572.1 - 0.004 17.0 13.8 0.073 12.9 0.1 3.7 4 0 0 4 4 4 2 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.14 KOO29572.1 - 0.0047 16.0 8.4 0.32 10.1 0.1 3.2 4 0 0 4 4 4 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF1880 PF08976.6 KOO29572.1 - 0.043 13.9 0.0 0.2 11.7 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1880) Caleosin PF05042.8 KOO29572.1 - 0.16 11.5 0.2 8 5.9 0.0 3.8 6 0 0 6 6 6 0 Caleosin related protein F420_oxidored PF03807.12 KOO29572.1 - 0.54 10.7 18.4 0.44 11.0 0.5 4.2 5 0 0 5 5 3 0 NADP oxidoreductase coenzyme F420-dependent Pyr_redox PF00070.22 KOO29572.1 - 7 7.1 9.9 24 5.4 0.1 4.1 4 0 0 4 4 4 0 Pyridine nucleotide-disulphide oxidoreductase SUR7 PF06687.7 KOO29574.1 - 0.014 15.0 0.2 0.02 14.4 0.1 1.3 1 1 0 1 1 1 0 SUR7/PalI family UPF0104 PF03706.8 KOO29574.1 - 0.017 14.4 2.4 0.02 14.1 1.7 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0104) BacteriocIIc_cy PF12173.3 KOO29574.1 - 0.1 12.6 2.0 0.8 9.7 0.1 2.1 2 0 0 2 2 2 0 Bacteriocin class IIc cyclic gassericin A-like MASE1 PF05231.9 KOO29574.1 - 0.19 10.6 6.6 1.8 7.4 0.4 2.0 2 0 0 2 2 2 0 MASE1 Sdh_cyt PF01127.17 KOO29574.1 - 0.21 11.4 5.2 0.1 12.3 0.3 2.0 1 1 1 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF1469 PF07332.6 KOO29574.1 - 0.31 10.7 3.4 3.1 7.5 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) ABC2_membrane_2 PF12679.2 KOO29574.1 - 0.77 8.5 3.1 5.6 5.7 0.0 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein MatE PF01554.13 KOO29575.1 - 8.2e-24 84.0 26.6 4.1e-17 62.2 4.5 2.4 2 0 0 2 2 2 2 MatE PP2C PF00481.16 KOO29576.1 - 2.9e-43 148.1 0.0 3.6e-43 147.7 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 KOO29576.1 - 2.1e-06 27.2 1.2 3e-05 23.5 0.9 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOO29576.1 - 6.8e-06 25.9 0.1 0.0011 18.6 0.0 2.4 2 1 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) Zip PF02535.17 KOO29577.1 - 1.7e-36 125.8 9.0 1.8e-36 125.7 6.2 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter SepZ PF06066.6 KOO29577.1 - 0.89 9.5 5.1 0.17 11.9 0.8 1.9 2 1 0 2 2 2 0 SepZ Strumpellin PF10266.4 KOO29578.1 - 2.8e-16 58.2 0.0 5.2e-16 57.3 0.0 1.4 1 0 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin Histone PF00125.19 KOO29580.1 - 9.9e-22 76.8 0.1 1.3e-21 76.4 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 RRM_1 PF00076.17 KOO29581.1 - 3.3e-19 68.2 0.0 1.5e-15 56.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO29581.1 - 6.7e-15 54.8 0.0 8.8e-12 44.8 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO29581.1 - 2.5e-10 40.0 0.2 2e-05 24.3 0.0 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LRR_4 PF12799.2 KOO29582.1 - 1.1e-12 47.2 3.5 7.6e-07 28.6 0.1 2.4 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.1 KOO29582.1 - 1.9e-10 40.6 0.0 3.1e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.1 KOO29582.1 - 5e-07 29.3 20.5 6.5e-05 22.6 3.4 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_6 PF13516.1 KOO29582.1 - 0.00011 21.8 1.5 1.7 8.9 0.1 4.2 4 0 0 4 4 4 1 Leucine Rich repeat LRR_7 PF13504.1 KOO29582.1 - 0.00011 21.7 2.9 3.7 8.1 0.2 4.4 4 0 0 4 4 4 2 Leucine rich repeat LRR_1 PF00560.28 KOO29582.1 - 0.00029 20.4 2.9 3.6 7.9 0.0 4.5 2 2 1 3 3 3 2 Leucine Rich Repeat Dev_Cell_Death PF10539.4 KOO29583.1 - 3.9e-17 62.0 0.1 4.1e-17 61.9 0.0 1.0 1 0 0 1 1 1 1 Development and cell death domain FYVE PF01363.16 KOO29584.1 - 1.2 9.0 5.5 0.47 10.3 1.1 2.0 2 0 0 2 2 2 0 FYVE zinc finger Prok-RING_1 PF14446.1 KOO29584.1 - 4.4 7.1 8.2 0.18 11.5 1.5 1.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Nuc-transf PF10127.4 KOO29585.1 - 1.1e-06 28.2 0.3 1.5e-06 27.7 0.2 1.2 1 0 0 1 1 1 1 Predicted nucleotidyltransferase EF-hand_1 PF00036.27 KOO29586.1 - 1e-40 133.9 1.2 3.2e-05 22.9 0.0 7.5 7 0 0 7 7 7 7 EF hand EF-hand_7 PF13499.1 KOO29586.1 - 3.1e-32 110.5 0.0 2.5e-05 24.3 0.0 7.3 6 1 0 6 6 6 6 EF-hand domain pair EF-hand_8 PF13833.1 KOO29586.1 - 4e-29 99.9 6.8 4.1e-05 23.0 0.0 8.4 7 1 1 8 8 8 7 EF-hand domain pair EF-hand_6 PF13405.1 KOO29586.1 - 5.9e-29 97.3 7.5 0.0027 17.4 0.2 7.5 7 0 0 7 7 7 7 EF-hand domain EF-hand_5 PF13202.1 KOO29586.1 - 1.3e-27 93.8 9.5 0.00013 21.1 0.0 6.6 6 0 0 6 6 6 6 EF hand EF-hand_4 PF12763.2 KOO29586.1 - 8.4e-07 28.6 0.1 9.8 5.9 0.0 6.7 7 1 0 7 7 7 1 Cytoskeletal-regulatory complex EF hand fn3 PF00041.16 KOO29586.1 - 2.4e-06 27.5 0.0 5e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain EF-hand_10 PF14788.1 KOO29586.1 - 0.0077 15.8 1.3 6.6 6.4 0.2 5.3 8 0 0 8 8 8 1 EF hand TcdB_toxin_midN PF12256.3 KOO29586.1 - 0.14 11.6 0.1 0.42 10.0 0.0 1.8 2 0 0 2 2 2 0 Insecticide toxin TcdB middle/N-terminal region VCBS PF13517.1 KOO29586.1 - 0.2 12.0 5.8 0.48 10.8 0.1 3.7 4 0 0 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella EF-hand_9 PF14658.1 KOO29586.1 - 0.22 11.4 0.1 19 5.2 0.0 3.8 4 0 0 4 4 4 0 EF-hand domain Cep57_MT_bd PF06657.8 KOO29587.1 - 0.00083 19.2 7.9 0.13 12.2 0.3 2.9 2 1 1 3 3 3 2 Centrosome microtubule-binding domain of Cep57 bZIP_1 PF00170.16 KOO29587.1 - 0.0045 16.9 8.8 0.03 14.2 0.3 3.4 3 1 0 3 3 3 1 bZIP transcription factor TMF_TATA_bd PF12325.3 KOO29587.1 - 0.0047 16.6 11.9 0.028 14.1 0.3 3.0 1 1 2 3 3 3 1 TATA element modulatory factor 1 TATA binding Filament PF00038.16 KOO29587.1 - 0.0064 15.9 12.2 0.012 15.1 8.3 1.6 1 1 0 1 1 1 1 Intermediate filament protein Cep57_CLD PF14073.1 KOO29587.1 - 0.032 14.0 10.5 0.07 12.9 7.3 1.6 1 1 0 1 1 1 0 Centrosome localisation domain of Cep57 Kinesin-relat_1 PF12711.2 KOO29587.1 - 0.21 11.9 5.3 0.2 12.0 0.3 2.7 2 1 0 2 2 2 0 Kinesin motor DUF904 PF06005.7 KOO29587.1 - 0.29 11.4 7.3 3.7 7.9 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF904) DDE_Tnp_IS66 PF03050.9 KOO29587.1 - 0.49 9.5 8.9 0.13 11.4 3.9 1.7 1 1 1 2 2 2 0 Transposase IS66 family IncA PF04156.9 KOO29587.1 - 0.5 9.9 15.0 1.2 8.7 5.4 2.8 1 1 1 2 2 2 0 IncA protein Jnk-SapK_ap_N PF09744.4 KOO29587.1 - 0.67 9.9 5.9 0.37 10.7 2.0 1.8 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DMPK_coil PF08826.5 KOO29587.1 - 0.75 9.7 8.5 2.8 7.9 0.5 3.5 2 1 1 3 3 3 0 DMPK coiled coil domain like Ax_dynein_light PF10211.4 KOO29587.1 - 0.95 9.2 9.8 0.26 11.1 0.2 2.4 1 1 2 3 3 3 0 Axonemal dynein light chain Rho_Binding PF08912.6 KOO29587.1 - 1.1 9.6 5.8 2.1 8.7 0.1 2.7 2 1 1 3 3 3 0 Rho Binding Spc24 PF08286.6 KOO29587.1 - 1.3 8.7 8.6 3 7.5 1.4 2.7 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 NPV_P10 PF05531.7 KOO29587.1 - 1.6 8.9 4.3 12 6.2 1.1 2.9 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Seryl_tRNA_N PF02403.17 KOO29587.1 - 1.7 8.6 12.7 2.5 8.1 2.7 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4201 PF13870.1 KOO29587.1 - 2.8 7.3 9.2 3.2 7.1 0.3 2.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4201) HALZ PF02183.13 KOO29587.1 - 3.2 7.5 7.3 7.3 6.4 0.5 3.3 3 0 0 3 3 3 0 Homeobox associated leucine zipper TPR_MLP1_2 PF07926.7 KOO29587.1 - 3.7 7.3 15.4 1.7e+03 -1.4 10.6 2.6 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Rab5-bind PF09311.6 KOO29587.1 - 4.3 7.1 16.7 2 8.2 5.8 2.0 1 1 1 2 2 2 0 Rabaptin-like protein DUF972 PF06156.8 KOO29587.1 - 4.7 7.5 7.3 13 6.2 0.9 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF972) AAA_13 PF13166.1 KOO29587.1 - 5.4 5.3 8.5 9.3 4.5 5.9 1.4 1 1 0 1 1 1 0 AAA domain V_ATPase_I PF01496.14 KOO29587.1 - 6.1 4.5 5.8 2.7 5.7 1.2 1.8 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family DUF4472 PF14739.1 KOO29587.1 - 7.6 7.0 9.9 5.3 7.5 1.3 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) DUF3641 PF12345.3 KOO29588.1 - 7.1e-47 158.6 0.0 1.2e-46 157.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3641) Radical_SAM PF04055.16 KOO29588.1 - 1.4e-09 38.3 0.0 6.5e-09 36.1 0.0 1.9 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_14 PF13394.1 KOO29588.1 - 0.0015 18.5 0.0 0.0033 17.4 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.1 KOO29588.1 - 0.0018 18.3 0.0 0.0038 17.3 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain Methyltransf_11 PF08241.7 KOO29589.1 - 2.3e-11 44.0 0.0 4.1e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO29589.1 - 6.8e-07 29.1 0.0 1.1e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO29589.1 - 6.9e-06 25.3 0.0 9.1e-06 24.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 KOO29589.1 - 3.7e-05 24.1 0.0 6.5e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.11 KOO29589.1 - 3.7e-05 22.2 0.0 4.8e-05 21.8 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_25 PF13649.1 KOO29589.1 - 5.9e-05 23.3 0.0 0.00012 22.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO29589.1 - 0.00013 21.5 0.0 0.0002 20.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 KOO29589.1 - 0.015 14.7 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_8 PF05148.10 KOO29589.1 - 0.05 13.2 0.0 0.07 12.7 0.0 1.2 1 0 0 1 1 1 0 Hypothetical methyltransferase HRDC PF00570.18 KOO29590.1 - 1.7e-16 59.6 1.4 2.2e-16 59.2 0.1 1.8 2 0 0 2 2 2 1 HRDC domain TylF PF05711.6 KOO29591.1 - 6.9e-46 156.3 0.0 1e-45 155.7 0.0 1.2 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) PPR_2 PF13041.1 KOO29591.1 - 3.6e-26 90.8 0.0 2e-11 43.6 0.0 4.4 3 1 1 4 4 4 4 PPR repeat family PPR_3 PF13812.1 KOO29591.1 - 5.9e-16 57.3 1.0 0.00018 21.5 0.0 5.9 5 0 0 5 5 5 2 Pentatricopeptide repeat domain PPR PF01535.15 KOO29591.1 - 6.7e-12 44.5 1.2 0.0017 18.1 0.0 4.8 6 0 0 6 6 6 3 PPR repeat PPR_1 PF12854.2 KOO29591.1 - 2.5e-09 36.4 1.8 0.017 14.5 0.0 4.4 6 0 0 6 6 6 3 PPR repeat Methyltransf_24 PF13578.1 KOO29591.1 - 3.2e-08 34.3 0.3 7.5e-07 29.9 0.0 2.9 2 1 0 2 2 2 1 Methyltransferase domain Pkinase PF00069.20 KOO29592.1 - 1.2e-21 77.0 0.0 3e-21 75.7 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29592.1 - 3.8e-20 72.0 0.1 3.5e-19 68.9 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Sugar_transport PF06800.7 KOO29593.1 - 8.1e-13 48.0 17.5 2e-10 40.1 0.6 2.6 3 0 0 3 3 3 2 Sugar transport protein DUF1632 PF07857.7 KOO29593.1 - 1.2e-06 28.0 3.2 0.0009 18.5 0.0 2.2 2 0 0 2 2 2 2 CEO family (DUF1632) Multi_Drug_Res PF00893.14 KOO29593.1 - 0.0084 16.5 5.6 0.0089 16.4 0.9 3.0 2 1 1 3 3 3 1 Small Multidrug Resistance protein Lysis_S PF04971.7 KOO29593.1 - 1.9 8.1 6.7 12 5.6 0.7 3.1 1 1 1 2 2 2 0 Lysis protein S Sulfotransfer_1 PF00685.22 KOO29594.1 - 1.5e-05 24.3 0.0 6.8e-05 22.2 0.0 1.9 2 1 0 2 2 2 1 Sulfotransferase domain Sulfotransfer_3 PF13469.1 KOO29594.1 - 0.0024 18.8 10.1 0.067 14.1 7.0 2.4 1 1 0 1 1 1 1 Sulfotransferase family LRR_6 PF13516.1 KOO29595.1 - 2.3e-25 85.7 5.0 0.0012 18.7 0.1 6.4 6 0 0 6 6 6 5 Leucine Rich repeat LRR_1 PF00560.28 KOO29595.1 - 4.5e-05 22.9 0.0 39 4.8 0.0 6.0 6 1 0 6 6 6 0 Leucine Rich Repeat YycC PF14174.1 KOO29595.1 - 0.014 15.0 0.2 49 3.6 0.0 4.4 5 0 0 5 5 5 0 YycC-like protein LRR_4 PF12799.2 KOO29595.1 - 0.031 13.9 9.4 0.84 9.3 0.2 4.9 2 1 4 6 6 6 0 Leucine Rich repeats (2 copies) CbiG_N PF11760.3 KOO29595.1 - 0.065 12.9 10.2 6.6 6.5 0.1 4.2 2 1 3 5 5 5 0 Cobalamin synthesis G N-terminal LRR_8 PF13855.1 KOO29595.1 - 0.086 12.6 5.7 6.4 6.6 0.5 4.7 2 1 1 4 4 4 0 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO29595.1 - 0.72 10.0 2.6 2.5 8.3 0.2 2.6 2 1 1 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding LRR_7 PF13504.1 KOO29595.1 - 4.5 7.8 14.2 21 5.8 0.1 5.8 7 0 0 7 7 7 0 Leucine rich repeat LVIVD PF08309.6 KOO29596.1 - 7.7e-52 172.0 43.3 6.7e-12 44.1 1.1 5.2 5 0 0 5 5 5 5 LVIVD repeat Beta_propel PF09826.4 KOO29596.1 - 3.6e-08 32.2 0.9 0.3 9.3 0.0 4.9 4 1 0 5 5 5 4 Beta propeller domain MTTB PF06253.6 KOO29596.1 - 0.02 12.6 1.7 0.65 7.6 0.1 2.3 2 0 0 2 2 2 0 Trimethylamine methyltransferase (MTTB) Lactonase PF10282.4 KOO29596.1 - 0.047 12.7 1.1 0.38 9.7 0.4 2.6 1 1 1 2 2 2 0 Lactonase, 7-bladed beta-propeller Chitin_bind_4 PF00379.18 KOO29596.1 - 0.19 12.0 12.2 26 5.1 0.0 5.2 5 0 0 5 5 5 0 Insect cuticle protein PQQ_3 PF13570.1 KOO29596.1 - 0.96 9.8 21.2 12 6.3 0.9 5.9 4 2 1 5 5 5 0 PQQ-like domain ADH_zinc_N_2 PF13602.1 KOO29598.1 - 1.7e-10 41.8 0.2 1.7e-10 41.8 0.1 1.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PAS_4 PF08448.5 KOO29598.1 - 0.059 13.3 0.0 0.066 13.2 0.0 1.1 1 0 0 1 1 1 0 PAS fold Pyrophosphatase PF00719.14 KOO29599.1 - 4.3e-47 159.4 0.1 6e-47 158.9 0.1 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase EF-hand_6 PF13405.1 KOO29599.1 - 4.8e-08 32.2 0.2 0.0016 18.1 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO29599.1 - 7.3e-08 32.4 0.1 1.5e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO29599.1 - 6.4e-07 28.2 0.1 0.024 13.9 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO29599.1 - 8.2e-05 22.1 0.4 0.00048 19.6 0.1 2.3 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO29599.1 - 0.0019 17.4 0.7 0.015 14.6 0.2 2.4 2 0 0 2 2 2 1 EF hand PPR_2 PF13041.1 KOO29600.1 - 2.1e-09 37.2 0.0 3e-05 23.9 0.0 3.9 4 0 0 4 4 4 2 PPR repeat family PPR_3 PF13812.1 KOO29600.1 - 4.3e-06 26.5 13.1 4.1e-05 23.5 0.0 6.0 6 1 0 6 6 6 1 Pentatricopeptide repeat domain PPR PF01535.15 KOO29600.1 - 0.00014 21.5 0.0 0.17 11.9 0.0 3.9 3 0 0 3 3 3 1 PPR repeat PPR_1 PF12854.2 KOO29600.1 - 0.069 12.6 6.5 0.58 9.6 0.0 4.0 5 0 0 5 5 5 0 PPR repeat Exostosin PF03016.10 KOO29601.1 - 6.5e-06 25.3 0.1 8.1e-06 25.0 0.0 1.4 1 1 0 1 1 1 1 Exostosin family Fib_alpha PF08702.5 KOO29603.1 - 0.0065 16.6 0.4 0.0065 16.6 0.3 4.2 2 1 0 4 4 4 1 Fibrinogen alpha/beta chain family HALZ PF02183.13 KOO29603.1 - 1.5 8.5 34.6 1.2 8.9 0.1 8.6 10 0 0 10 10 10 0 Homeobox associated leucine zipper Radical_SAM PF04055.16 KOO29604.1 - 7.6e-23 81.5 0.0 2.2e-10 40.9 0.0 2.3 2 0 0 2 2 2 2 Radical SAM superfamily DeoC PF01791.4 KOO29604.1 - 0.13 11.5 0.0 0.35 10.1 0.0 1.7 1 0 0 1 1 1 0 DeoC/LacD family aldolase Pkinase PF00069.20 KOO29605.1 - 7.8e-29 100.6 0.0 1.1e-28 100.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29605.1 - 2.9e-12 46.2 0.0 4.2e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO29605.1 - 1.2e-05 25.1 3.0 0.017 14.8 0.2 3.2 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.9 KOO29605.1 - 0.00012 21.2 0.0 0.00023 20.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 KOO29605.1 - 0.11 11.4 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 Kinase-like BT1 PF03092.11 KOO29607.1 - 6.1e-14 51.5 10.3 2.6e-09 36.3 3.1 3.2 2 1 0 2 2 2 2 BT1 family MFS_1 PF07690.11 KOO29607.1 - 3.6e-05 22.6 4.1 3.6e-05 22.6 2.8 3.5 1 1 2 3 3 3 2 Major Facilitator Superfamily Ank_2 PF12796.2 KOO29608.1 - 8.7e-09 35.6 0.0 0.0076 16.5 0.0 3.6 2 2 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO29608.1 - 4.4e-06 26.4 0.1 0.46 10.8 0.0 4.7 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.25 KOO29608.1 - 6.3e-06 25.7 0.6 2.7 7.9 0.0 5.0 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.1 KOO29608.1 - 1.8e-05 24.8 0.1 1.7 9.0 0.0 4.4 5 0 0 5 5 5 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO29608.1 - 0.089 13.3 0.0 17 6.0 0.0 3.5 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Filamin PF00630.14 KOO29609.1 - 9e-20 71.1 0.0 2.9e-08 34.2 0.0 3.2 3 0 0 3 3 3 3 Filamin/ABP280 repeat SH3_3 PF08239.6 KOO29609.1 - 2e-05 24.6 0.0 4.7e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain Big_1 PF02369.11 KOO29609.1 - 0.011 15.6 1.2 0.033 14.0 0.1 2.4 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 1) PKD PF00801.15 KOO29609.1 - 0.056 13.2 1.3 6.6 6.5 0.0 3.8 4 0 0 4 4 4 0 PKD domain Big_3_4 PF13754.1 KOO29609.1 - 0.35 11.2 6.0 4.2 7.7 0.9 3.0 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 3) SET PF00856.23 KOO29610.1 - 1.1e-28 100.5 0.3 8.7e-28 97.6 0.2 2.2 1 1 0 1 1 1 1 SET domain Pre-SET PF05033.11 KOO29610.1 - 1e-18 67.4 2.2 1e-18 67.4 1.6 2.0 2 0 0 2 2 2 1 Pre-SET motif Gly-zipper_YMGG PF13441.1 KOO29610.1 - 0.098 12.1 0.3 0.098 12.1 0.2 2.4 2 0 0 2 2 2 0 YMGG-like Gly-zipper Gly-zipper_Omp PF13488.1 KOO29610.1 - 4.7 6.9 16.8 0.047 13.3 1.6 2.4 2 0 0 2 2 2 0 Glycine zipper Band_7 PF01145.20 KOO29611.1 - 9.5e-09 35.4 0.2 1.8e-08 34.5 0.2 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family UQ_con PF00179.21 KOO29613.1 - 5.8e-43 145.6 0.0 7.5e-43 145.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KOO29613.1 - 0.0002 21.0 0.0 0.00038 20.2 0.0 1.4 1 1 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.8 KOO29613.1 - 0.0066 16.1 0.1 0.013 15.1 0.1 1.5 1 1 0 1 1 1 1 UEV domain RWD PF05773.17 KOO29613.1 - 0.01 15.7 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 0 RWD domain Ion_trans PF00520.26 KOO29614.1 - 2e-15 56.5 1.9 2e-15 56.5 1.3 1.8 2 1 0 2 2 2 1 Ion transport protein Ion_trans_2 PF07885.11 KOO29614.1 - 3.4e-06 26.6 6.6 3.4e-06 26.6 4.6 3.2 3 1 1 4 4 4 1 Ion channel SHOCT PF09851.4 KOO29614.1 - 0.009 15.4 0.2 0.019 14.4 0.1 1.6 1 0 0 1 1 1 1 Short C-terminal domain IRK PF01007.15 KOO29614.1 - 0.077 11.7 0.1 0.16 10.7 0.1 1.5 1 0 0 1 1 1 0 Inward rectifier potassium channel GvpG PF05120.7 KOO29614.1 - 0.079 12.7 1.2 0.14 12.0 0.4 1.7 2 0 0 2 2 2 0 Gas vesicle protein G Ald_Xan_dh_C2 PF02738.13 KOO29615.1 - 8.9e-86 288.3 0.2 8.9e-86 288.3 0.1 2.3 2 0 0 2 2 2 1 Molybdopterin-binding domain of aldehyde dehydrogenase Fer2_2 PF01799.15 KOO29615.1 - 2.1e-24 85.2 0.8 5.7e-24 83.8 0.6 1.8 1 0 0 1 1 1 1 [2Fe-2S] binding domain Ald_Xan_dh_C PF01315.17 KOO29615.1 - 9.3e-17 61.1 0.8 2.5e-16 59.7 0.6 1.8 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain FAD_binding_5 PF00941.16 KOO29615.1 - 1.1e-15 57.5 0.0 3.1e-15 56.0 0.0 1.9 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Fer2 PF00111.22 KOO29615.1 - 2.2e-05 24.1 2.3 7.2e-05 22.4 0.2 2.5 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain PPR_2 PF13041.1 KOO29616.1 - 4.3e-55 183.4 0.0 1.9e-07 30.9 0.0 9.4 2 2 7 10 10 10 10 PPR repeat family PPR_3 PF13812.1 KOO29616.1 - 7.7e-48 156.7 16.9 8.6e-05 22.5 0.1 12.6 12 1 0 12 12 12 10 Pentatricopeptide repeat domain PPR PF01535.15 KOO29616.1 - 8.5e-40 131.9 9.5 0.00038 20.2 0.1 12.2 13 0 0 13 13 13 9 PPR repeat PPR_1 PF12854.2 KOO29616.1 - 1.3e-29 101.3 1.1 0.00012 21.4 0.0 11.4 13 1 0 13 13 13 6 PPR repeat TPR_19 PF14559.1 KOO29616.1 - 0.011 16.1 3.8 5.3 7.4 0.1 4.4 3 1 0 4 4 4 0 Tetratricopeptide repeat ECSIT PF06239.6 KOO29616.1 - 0.017 14.0 0.0 14 4.5 0.0 4.6 4 1 0 4 4 4 0 Evolutionarily conserved signalling intermediate in Toll pathway PDZ PF00595.19 KOO29616.1 - 0.02 15.0 0.0 0.045 13.9 0.0 1.5 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) RRM_1 PF00076.17 KOO29617.1 - 7.5e-19 67.1 0.1 1.3e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO29617.1 - 7.7e-15 54.6 0.1 4.1e-14 52.3 0.1 2.0 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) CSTF2_hinge PF14327.1 KOO29617.1 - 1.7e-11 44.0 0.1 4.7e-11 42.6 0.0 1.6 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_5 PF13893.1 KOO29617.1 - 9.2e-05 22.2 0.1 0.0002 21.1 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Na_H_Exchanger PF00999.16 KOO29619.1 - 3.3e-52 177.3 30.1 4.4e-52 176.8 20.9 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family zf-CCHC PF00098.18 KOO29621.1 - 0.026 14.4 1.0 0.042 13.7 0.7 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_6 PF15288.1 KOO29621.1 - 0.12 12.0 0.6 0.25 11.0 0.4 1.5 1 0 0 1 1 1 0 Zinc knuckle RVT_2 PF07727.9 KOO29622.1 - 3.7e-32 111.2 0.0 5.2e-32 110.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Nucleotid_trans PF03407.11 KOO29623.1 - 1.4e-22 80.5 0.0 1.8e-22 80.1 0.0 1.1 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Glyco_transf_8 PF01501.15 KOO29623.1 - 0.1 11.9 0.0 0.13 11.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 8 Anoctamin PF04547.7 KOO29624.1 - 4.3e-101 338.7 6.5 5.2e-101 338.5 4.5 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel ART PF01129.13 KOO29625.1 - 4e-05 22.8 0.0 0.00031 19.9 0.0 2.0 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.9 KOO29625.1 - 0.00033 19.9 0.0 0.00057 19.1 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme HAD_2 PF13419.1 KOO29630.1 - 0.011 15.9 0.0 0.014 15.6 0.0 1.2 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DUF3320 PF11784.3 KOO29630.1 - 0.098 12.1 0.1 0.2 11.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3320) Tetraspannin PF00335.15 KOO29631.1 - 0.00028 20.2 7.2 0.00028 20.2 5.0 2.1 2 0 0 2 2 2 1 Tetraspanin family DEAD PF00270.24 KOO29633.1 - 6.9e-47 159.0 0.0 1.2e-46 158.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO29633.1 - 1.1e-21 76.4 0.2 3.9e-21 74.6 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 KOO29633.1 - 0.04 14.0 0.1 0.19 11.9 0.0 2.2 1 1 0 1 1 1 0 AAA domain ResIII PF04851.10 KOO29633.1 - 0.048 13.4 0.0 0.13 12.1 0.0 1.7 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit SecA_DEAD PF07517.9 KOO29633.1 - 0.071 12.3 0.0 0.25 10.5 0.0 1.7 1 1 0 1 1 1 0 SecA DEAD-like domain Macoilin PF09726.4 KOO29634.1 - 0.00088 17.6 8.2 0.0012 17.2 5.7 1.2 1 0 0 1 1 1 1 Transmembrane protein Not3 PF04065.10 KOO29634.1 - 0.065 12.4 4.8 0.1 11.8 2.9 1.4 1 1 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component Reo_sigmaC PF04582.7 KOO29634.1 - 0.35 10.0 6.2 0.12 11.5 2.0 1.8 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Spc24 PF08286.6 KOO29634.1 - 0.46 10.1 2.7 0.94 9.1 1.6 1.7 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 SOBP PF15279.1 KOO29634.1 - 0.73 10.1 4.5 0.9 9.8 3.1 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein ERM PF00769.14 KOO29634.1 - 1.3 8.5 26.0 1.8 8.0 17.7 1.5 1 1 0 1 1 1 0 Ezrin/radixin/moesin family APG6 PF04111.7 KOO29634.1 - 1.8 7.5 9.4 2.3 7.1 6.5 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Corona_nucleoca PF00937.13 KOO29634.1 - 2.5 6.9 8.5 3.2 6.5 5.9 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Seryl_tRNA_N PF02403.17 KOO29634.1 - 2.7 8.0 9.5 2 8.4 5.2 1.9 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain NifQ PF04891.7 KOO29634.1 - 3.4 7.7 12.7 1.9 8.6 6.1 2.1 2 0 0 2 2 2 0 NifQ AAA_13 PF13166.1 KOO29634.1 - 4 5.7 6.7 5.2 5.4 4.6 1.1 1 0 0 1 1 1 0 AAA domain Mito_fiss_reg PF05308.6 KOO29634.1 - 5.2 6.3 11.5 1 8.6 5.4 1.8 2 0 0 2 2 2 0 Mitochondrial fission regulator PP2C PF00481.16 KOO29635.1 - 5.9e-27 94.6 0.6 9.4e-13 48.1 0.1 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.1 KOO29635.1 - 7.2e-06 25.5 0.2 1.3e-05 24.6 0.1 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOO29635.1 - 0.00051 19.8 0.1 0.0013 18.5 0.0 1.6 1 1 1 2 2 2 1 Stage II sporulation protein E (SpoIIE) DUF1995 PF09353.5 KOO29636.1 - 2e-08 34.1 0.1 5.9e-07 29.3 0.0 2.6 1 1 0 1 1 1 1 Domain of unknown function (DUF1995) SRP54_N PF02881.14 KOO29636.1 - 0.057 13.5 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, helical bundle domain SIR2 PF02146.12 KOO29637.1 - 5.4e-49 166.3 0.0 6.7e-49 166.0 0.0 1.1 1 0 0 1 1 1 1 Sir2 family BmKX PF09132.5 KOO29637.1 - 0.064 13.1 0.3 0.15 11.9 0.2 1.6 1 0 0 1 1 1 0 BmKX Cwf_Cwc_15 PF04889.7 KOO29637.1 - 4.1 7.0 9.6 6 6.5 6.6 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.9 KOO29637.1 - 6.3 4.6 6.8 8.5 4.2 4.7 1.1 1 0 0 1 1 1 0 CDC45-like protein TPT PF03151.11 KOO29638.1 - 1.6e-22 79.8 6.0 1.6e-22 79.8 4.2 2.3 2 1 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.15 KOO29638.1 - 2.7e-09 37.1 21.9 2e-06 27.8 6.4 2.9 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.6 KOO29638.1 - 0.0096 14.8 9.5 0.026 13.4 6.6 1.8 1 1 0 1 1 1 1 UAA transporter family EmrE PF13536.1 KOO29638.1 - 0.38 10.9 23.4 0.58 10.3 1.9 3.7 1 1 3 4 4 4 0 Multidrug resistance efflux transporter Mito_fiss_reg PF05308.6 KOO29639.1 - 3.1 7.0 6.5 4.2 6.6 4.5 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator FKBP_C PF00254.23 KOO29640.1 - 1.4e-29 101.9 0.0 2e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase MdcE PF06833.6 KOO29640.1 - 0.042 13.0 0.1 0.056 12.6 0.1 1.1 1 0 0 1 1 1 0 Malonate decarboxylase gamma subunit (MdcE) AhpC-TSA_2 PF13911.1 KOO29641.1 - 0.00036 20.4 0.0 0.00046 20.0 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme CTDII PF01556.13 KOO29642.1 - 0.00088 19.1 0.0 0.21 11.5 0.0 3.3 3 2 0 3 3 3 2 DnaJ C terminal domain LRR_6 PF13516.1 KOO29643.1 - 4.6e-27 91.0 8.6 8.3e-05 22.2 0.1 7.5 7 1 0 7 7 7 5 Leucine Rich repeat LRR_4 PF12799.2 KOO29643.1 - 9.5e-07 28.3 8.8 0.67 9.6 0.1 6.2 2 2 4 6 6 6 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO29643.1 - 5.5e-05 22.6 0.1 1.1e+02 3.4 0.0 6.6 7 0 0 7 7 7 0 Leucine Rich Repeat CbiG_N PF11760.3 KOO29643.1 - 0.0034 17.0 10.5 1.2 8.8 0.1 4.1 3 1 1 4 4 4 3 Cobalamin synthesis G N-terminal LRR_7 PF13504.1 KOO29643.1 - 0.0038 17.1 10.7 31 5.3 0.0 7.2 7 1 0 7 7 7 0 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO29643.1 - 0.015 15.4 2.8 1.3 9.2 0.2 3.8 2 1 2 4 4 4 0 RNA 2'-O ribose methyltransferase substrate binding YusW PF14039.1 KOO29643.1 - 0.28 11.4 2.7 8 6.8 0.3 3.4 2 1 1 3 3 3 0 YusW-like protein Adeno_shaft PF00608.12 KOO29644.1 - 0.062 12.9 0.0 92 2.9 0.0 4.7 5 0 0 5 5 5 0 Adenoviral fibre protein (repeat/shaft region) LRR_6 PF13516.1 KOO29645.1 - 0.002 18.0 0.0 0.0049 16.7 0.0 1.6 1 0 0 1 1 1 1 Leucine Rich repeat EMP70 PF02990.11 KOO29646.1 - 7.1e-221 734.1 4.4 1e-220 733.6 3.1 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 Acetyltransf_6 PF13480.1 KOO29648.1 - 0.14 12.1 0.2 0.24 11.3 0.1 1.5 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 KOO29649.1 - 1.1e-08 34.9 0.4 3e-08 33.5 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 KOO29649.1 - 0.00016 21.7 0.0 0.00045 20.3 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 KOO29649.1 - 0.00046 20.3 0.0 0.00075 19.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain AAA_16 PF13191.1 KOO29650.1 - 7.7e-05 22.7 0.0 7.7e-05 22.7 0.0 2.9 2 1 0 2 2 2 1 AAA ATPase domain Nodulin PF02451.10 KOO29650.1 - 0.021 14.3 0.1 0.021 14.3 0.0 1.6 2 0 0 2 2 2 0 Nodulin APS_kinase PF01583.15 KOO29650.1 - 0.026 14.1 0.0 0.056 13.1 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase Viral_helicase1 PF01443.13 KOO29650.1 - 0.074 12.5 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_29 PF13555.1 KOO29650.1 - 0.077 12.5 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF815 PF05673.8 KOO29650.1 - 0.08 11.8 0.0 0.15 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) UPF0079 PF02367.12 KOO29650.1 - 0.088 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA PF00004.24 KOO29650.1 - 0.09 12.9 0.0 0.26 11.4 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.11 KOO29650.1 - 0.15 11.2 0.0 0.28 10.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 EF-hand_7 PF13499.1 KOO29651.1 - 8.5e-15 54.6 1.4 1.3e-14 54.0 0.4 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO29651.1 - 4.8e-13 47.3 4.7 7.5e-07 28.0 0.1 3.0 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO29651.1 - 7.7e-11 40.9 1.8 0.00039 20.0 0.1 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 KOO29651.1 - 1.3e-09 37.5 1.5 4.4e-09 35.8 0.3 1.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO29651.1 - 1.8e-07 30.1 4.7 0.0045 16.2 0.0 3.1 4 0 0 4 4 4 2 EF hand WW PF00397.21 KOO29652.1 - 0.00043 20.0 4.2 0.16 11.8 0.6 3.4 3 0 0 3 3 3 2 WW domain Kinesin PF00225.18 KOO29654.1 - 3.6e-55 187.0 0.0 1e-54 185.5 0.0 1.7 2 0 0 2 2 2 1 Kinesin motor domain DUF4201 PF13870.1 KOO29654.1 - 1.2 8.5 11.3 0.25 10.7 3.1 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4201) DUF1515 PF07439.6 KOO29654.1 - 2.4 8.0 6.2 0.58 9.9 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) GAS PF13851.1 KOO29654.1 - 5.6 6.1 15.7 1 8.4 3.3 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding IncA PF04156.9 KOO29654.1 - 8.1 5.9 26.4 0.47 10.0 5.3 2.8 1 1 1 2 2 2 0 IncA protein Nicastrin PF05450.10 KOO29656.1 - 1.7e-21 76.5 0.0 2.3e-21 76.1 0.0 1.1 1 0 0 1 1 1 1 Nicastrin Sulfatase PF00884.18 KOO29657.1 - 4.9e-50 170.4 0.0 4.6e-49 167.2 0.0 2.0 1 1 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.1 KOO29657.1 - 3.3e-05 24.1 0.0 8.7e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphoesterase PF04185.9 KOO29657.1 - 0.1 11.7 0.0 5.2 6.1 0.0 2.4 3 0 0 3 3 3 0 Phosphoesterase family Aha1_N PF09229.6 KOO29658.1 - 1.6e-32 112.2 0.9 2.9e-32 111.3 0.6 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.6 KOO29658.1 - 1.2e-16 60.9 0.0 3e-16 59.6 0.0 1.6 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein WD40 PF00400.27 KOO29659.1 - 4.9e-34 114.9 15.5 9.9e-09 34.7 0.1 6.6 6 1 1 7 7 7 5 WD domain, G-beta repeat eIF2A PF08662.6 KOO29659.1 - 2.5e-07 30.6 0.2 0.00024 20.8 0.0 2.9 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Abhydrolase_1 PF00561.15 KOO29660.1 - 2.4e-15 56.7 0.1 2.9e-11 43.3 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_4 PF08386.5 KOO29660.1 - 1.5e-08 34.4 0.0 1.1e-07 31.7 0.0 2.2 1 1 0 1 1 1 1 TAP-like protein Abhydrolase_6 PF12697.2 KOO29660.1 - 1.8e-08 34.5 2.8 8.1e-08 32.4 1.9 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO29660.1 - 0.0026 17.5 0.0 0.052 13.3 0.0 2.2 2 0 0 2 2 2 1 Alpha/beta hydrolase family mTERF PF02536.9 KOO29662.1 - 1.9e-20 72.7 0.0 4e-11 42.0 0.0 3.1 1 1 2 3 3 3 3 mTERF Acyl_transf_3 PF01757.17 KOO29662.1 - 1.6e-09 37.0 2.9 2.3e-09 36.5 2.0 1.2 1 0 0 1 1 1 1 Acyltransferase family DUF2629 PF10945.3 KOO29662.1 - 0.13 11.6 1.3 0.45 9.8 0.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2629) Pkinase PF00069.20 KOO29663.1 - 2.1e-69 233.5 0.0 2.8e-69 233.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29663.1 - 2.1e-34 118.7 0.0 2.5e-34 118.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO29663.1 - 0.00031 19.8 0.0 0.00099 18.1 0.0 1.7 1 1 0 2 2 2 1 Kinase-like RIO1 PF01163.17 KOO29663.1 - 0.0036 16.6 0.0 0.0052 16.1 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 KOO29663.1 - 0.0043 16.8 0.1 0.006 16.3 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 KOO29663.1 - 0.049 12.6 0.1 0.11 11.5 0.1 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 KOO29663.1 - 0.081 11.7 0.1 0.11 11.2 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 AA_permease_2 PF13520.1 KOO29665.1 - 8.3e-28 97.0 20.6 4e-27 94.8 14.3 1.8 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KOO29665.1 - 6.2e-07 28.1 12.9 6.2e-07 28.1 9.0 1.7 2 0 0 2 2 2 1 Amino acid permease Homeobox PF00046.24 KOO29666.1 - 1.1e-17 63.4 0.4 2.7e-17 62.1 0.3 1.6 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.6 KOO29666.1 - 0.00018 21.1 0.3 0.00043 19.9 0.2 1.6 1 0 0 1 1 1 1 Homeobox KN domain Sugar_tr PF00083.19 KOO29668.1 - 2.2e-85 286.9 15.8 2.6e-85 286.7 10.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOO29668.1 - 2.4e-23 82.4 58.4 6.2e-19 67.9 19.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Romo1 PF10247.4 KOO29668.1 - 1.9 8.7 7.2 0.28 11.4 1.1 2.5 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 Vma12 PF11712.3 KOO29668.1 - 2.5 7.7 4.0 1.9 8.1 1.2 2.0 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase PP2C PF00481.16 KOO29669.1 - 7.9e-27 94.2 0.0 1.1e-26 93.7 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 KOO29669.1 - 0.024 14.0 0.6 0.19 11.1 0.4 2.0 1 1 0 1 1 1 0 Protein phosphatase 2C WD40 PF00400.27 KOO29669.1 - 0.024 14.5 0.0 0.05 13.5 0.0 1.6 1 0 0 1 1 1 0 WD domain, G-beta repeat Fis1_TPR_C PF14853.1 KOO29670.1 - 7.4 6.5 10.4 10 6.0 1.8 3.2 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat RCC1 PF00415.13 KOO29671.1 - 1.3e-54 182.2 17.3 9.3e-13 48.1 0.3 7.1 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO29671.1 - 4.2e-32 109.0 38.6 4e-08 32.6 1.0 6.8 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat Filamin PF00630.14 KOO29671.1 - 6.7e-06 26.6 0.0 0.0031 18.0 0.0 3.2 3 0 0 3 3 3 1 Filamin/ABP280 repeat EDR1 PF14381.1 KOO29671.1 - 0.012 15.1 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 Ethylene-responsive protein kinase Le-CTR1 EF-hand_1 PF00036.27 KOO29672.1 - 6.3e-58 187.7 13.2 5e-07 28.5 1.0 11.2 11 0 0 11 11 11 10 EF hand EF-hand_6 PF13405.1 KOO29672.1 - 3.5e-53 172.7 15.6 1e-06 28.0 0.9 10.9 11 0 0 11 11 11 10 EF-hand domain EF-hand_7 PF13499.1 KOO29672.1 - 1.1e-45 153.5 10.4 4.5e-10 39.5 0.2 8.1 4 2 4 8 8 8 8 EF-hand domain pair EF-hand_5 PF13202.1 KOO29672.1 - 9.1e-37 122.7 29.2 4.6e-07 28.8 1.7 12.0 12 0 0 12 12 12 10 EF hand EF-hand_8 PF13833.1 KOO29672.1 - 4.4e-33 112.6 15.9 0.00025 20.5 1.6 10.2 6 4 4 10 10 10 10 EF-hand domain pair EF-hand_10 PF14788.1 KOO29672.1 - 3.8e-05 23.2 2.6 21 4.8 0.0 6.7 7 1 1 8 8 8 1 EF hand EF-hand_4 PF12763.2 KOO29672.1 - 0.0079 15.9 7.7 6.6 6.5 0.0 6.3 6 1 1 7 7 7 1 Cytoskeletal-regulatory complex EF hand Asp_Arg_Hydrox PF05118.10 KOO29673.1 - 1.7e-32 112.4 0.0 4.5e-32 111.1 0.0 1.7 1 1 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase Holin_LLH PF09682.5 KOO29673.1 - 0.12 12.4 0.1 0.19 11.8 0.1 1.3 1 0 0 1 1 1 0 Phage holin protein (Holin_LLH) FTCD_N PF07837.7 KOO29674.1 - 3.1e-19 69.1 0.0 1.1e-18 67.3 0.0 1.8 2 0 0 2 2 2 1 Formiminotransferase domain, N-terminal subdomain Rad21_Rec8_N PF04825.8 KOO29675.1 - 4.8e-34 116.6 0.0 8.5e-34 115.8 0.0 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.11 KOO29675.1 - 6.5e-08 31.6 0.1 5.1e-05 22.3 0.0 2.4 2 0 0 2 2 2 2 Conserved region of Rad21 / Rec8 like protein ScpA_ScpB PF02616.9 KOO29675.1 - 0.0062 16.1 0.0 0.016 14.8 0.0 1.6 2 0 0 2 2 2 1 ScpA/B protein Cgr1 PF03879.9 KOO29676.1 - 0.028 14.5 2.0 0.046 13.8 1.4 1.3 1 0 0 1 1 1 0 Cgr1 family RRM_6 PF14259.1 KOO29677.1 - 0.017 15.0 0.0 0.032 14.2 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) MerR_1 PF13411.1 KOO29678.1 - 8.2e-08 31.9 0.0 12 5.7 0.0 8.7 6 2 0 9 9 9 1 MerR HTH family regulatory protein Ribosomal_L13e PF01294.13 KOO29678.1 - 8.7e-07 28.5 8.0 0.16 11.4 0.0 6.1 2 2 4 6 6 6 3 Ribosomal protein L13e TFIID_30kDa PF03540.8 KOO29678.1 - 0.00072 19.3 3.0 1.1e+02 2.6 0.0 7.8 8 2 2 10 10 10 0 Transcription initiation factor TFIID 23-30kDa subunit RPAP1_C PF08620.5 KOO29678.1 - 0.0045 16.8 6.1 42 4.0 0.0 7.6 7 2 4 11 11 11 0 RPAP1-like, C-terminal PARP PF00644.15 KOO29678.1 - 0.028 13.8 0.4 0.8 9.0 0.0 2.4 1 1 1 2 2 2 0 Poly(ADP-ribose) polymerase catalytic domain Pyr_redox_dim PF02852.17 KOO29678.1 - 2.5 8.1 12.1 15 5.6 0.3 5.4 3 2 4 7 7 7 0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Rieske PF00355.21 KOO29679.1 - 4e-16 58.3 0.0 5.5e-16 57.9 0.0 1.2 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.1 KOO29679.1 - 1.7e-13 50.1 0.0 2.4e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain RRM_1 PF00076.17 KOO29680.1 - 1.1e-17 63.4 0.0 1.6e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO29680.1 - 4.6e-14 52.1 0.0 7.7e-14 51.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO29680.1 - 1.3e-08 34.5 0.0 2.1e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.1 KOO29680.1 - 3.4e-06 27.3 1.6 3.4e-06 27.3 1.1 4.3 2 2 1 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 DUF972 PF06156.8 KOO29681.1 - 0.054 13.8 15.5 0.61 10.4 1.3 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF972) Atg14 PF10186.4 KOO29681.1 - 3 6.6 16.4 0.24 10.3 6.3 2.3 2 1 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Herpes_BLRF2 PF05812.7 KOO29681.1 - 5.9 6.7 22.3 2.8 7.7 0.0 4.5 4 1 0 4 4 4 0 Herpesvirus BLRF2 protein WD40 PF00400.27 KOO29682.1 - 7.6e-27 92.1 12.3 3.4e-05 23.5 0.0 5.6 5 1 1 6 6 6 5 WD domain, G-beta repeat DUF3611 PF12263.3 KOO29683.1 - 4.4e-34 117.4 7.6 5.7e-34 117.1 5.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3611) DUF3185 PF11381.3 KOO29683.1 - 0.16 11.7 10.1 1.1 9.1 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) DUF3040 PF11239.3 KOO29683.1 - 5.6 7.0 6.8 23 5.1 1.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Ribosomal_L19e PF01280.15 KOO29684.1 - 3.7e-62 208.4 13.9 3.7e-62 208.4 9.7 1.3 2 0 0 2 2 2 1 Ribosomal protein L19e DUF2513 PF10711.4 KOO29684.1 - 0.015 15.3 1.2 3.1 7.9 0.0 2.2 2 0 0 2 2 2 0 Hypothetical protein (DUF2513) ATP-synt_C PF00137.16 KOO29685.1 - 1.6e-32 111.1 27.2 1.3e-19 69.8 5.5 2.1 2 0 0 2 2 2 2 ATP synthase subunit C PRTP PF01366.13 KOO29686.1 - 0.16 9.9 0.3 0.22 9.4 0.2 1.1 1 0 0 1 1 1 0 Herpesvirus processing and transport protein AP2 PF00847.15 KOO29687.1 - 7.7e-07 29.1 0.7 1.7e-06 28.0 0.2 1.8 2 0 0 2 2 2 1 AP2 domain HAD_2 PF13419.1 KOO29689.1 - 0.031 14.5 0.0 0.035 14.3 0.0 1.0 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Glycos_trans_3N PF02885.12 KOO29689.1 - 0.12 11.9 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family, helical bundle domain DUF179 PF02622.10 KOO29690.1 - 1e-12 47.9 0.0 1.1e-11 44.6 0.0 2.5 2 1 0 2 2 2 1 Uncharacterized ACR, COG1678 Ribosomal_L7Ae PF01248.21 KOO29690.1 - 4.9e-09 35.5 0.9 1.3e-07 30.9 0.6 2.3 1 1 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Peptidase_C12 PF01088.16 KOO29691.1 - 4.7e-53 179.5 0.0 5.5e-53 179.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Glyco_transf_25 PF01755.12 KOO29692.1 - 1.5e-10 41.0 0.0 7.4e-09 35.5 0.0 2.7 1 1 1 2 2 2 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Mito_fiss_reg PF05308.6 KOO29692.1 - 0.3 10.4 1.3 0.45 9.8 0.9 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator MBF1 PF08523.5 KOO29694.1 - 0.029 14.4 2.5 0.029 14.4 1.8 1.8 2 0 0 2 2 2 0 Multiprotein bridging factor 1 Adeno_PIX PF03955.9 KOO29694.1 - 0.11 12.9 5.6 1.5 9.3 0.3 2.9 2 1 0 2 2 2 0 Adenovirus hexon-associated protein (IX) PmbA_TldD PF01523.11 KOO29694.1 - 0.53 9.4 4.3 0.33 10.1 0.3 2.1 2 0 0 2 2 2 0 Putative modulator of DNA gyrase SAP PF02037.22 KOO29695.1 - 4.8e-11 41.8 0.5 1.4e-10 40.4 0.4 1.8 2 0 0 2 2 2 1 SAP domain HeH PF12949.2 KOO29695.1 - 0.00039 19.9 0.4 0.0043 16.5 0.1 2.3 2 0 0 2 2 2 1 HeH/LEM domain BRCT PF00533.21 KOO29695.1 - 0.0004 20.4 0.0 0.00068 19.7 0.0 1.3 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 KOO29695.1 - 0.019 14.8 0.0 0.054 13.3 0.0 1.8 1 1 0 1 1 1 0 twin BRCT domain DUF2890 PF11081.3 KOO29695.1 - 0.041 13.9 3.4 0.076 13.0 2.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Myc_N PF01056.13 KOO29695.1 - 0.06 12.5 2.5 0.093 11.8 1.7 1.4 1 0 0 1 1 1 0 Myc amino-terminal region Nop14 PF04147.7 KOO29695.1 - 0.92 7.3 6.8 1.1 7.0 4.7 1.0 1 0 0 1 1 1 0 Nop14-like family Daxx PF03344.10 KOO29695.1 - 1.4 7.2 7.3 1.8 6.9 5.1 1.1 1 0 0 1 1 1 0 Daxx Family PARP PF00644.15 KOO29696.1 - 9.4e-62 208.0 0.0 1.6e-61 207.3 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.9 KOO29696.1 - 1.2e-26 92.9 0.0 1.8e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain CHAT PF12770.2 KOO29696.1 - 0.0012 18.0 2.3 0.002 17.3 1.6 1.2 1 0 0 1 1 1 1 CHAT domain PRT_C PF08372.5 KOO29696.1 - 0.074 12.5 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal PNTB PF02233.11 KOO29697.1 - 1e-159 532.2 15.7 1e-159 532.2 10.9 2.3 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.16 KOO29697.1 - 1.6e-49 167.7 3.1 5.4e-49 165.9 1.0 2.3 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.10 KOO29697.1 - 1.9e-33 115.3 0.3 5.7e-33 113.8 0.0 1.9 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, N-terminal domain DUF3814 PF12769.2 KOO29697.1 - 9.2e-30 102.6 3.6 9.2e-30 102.6 2.5 4.0 3 1 1 4 4 4 1 Domain of unknown function (DUF3814) 2-Hacid_dh_C PF02826.14 KOO29697.1 - 0.00041 19.5 0.1 0.085 11.9 0.0 2.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N PF00107.21 KOO29697.1 - 0.0013 18.3 0.7 0.0043 16.6 0.2 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase NAD_binding_8 PF13450.1 KOO29697.1 - 0.0039 17.1 0.3 0.021 14.8 0.2 2.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.13 KOO29697.1 - 0.0091 15.6 0.4 0.02 14.5 0.3 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 KOO29697.1 - 0.011 15.7 2.6 13 5.8 0.1 3.8 4 0 0 4 4 4 0 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.9 KOO29697.1 - 0.03 14.2 0.1 0.08 12.8 0.1 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TPP_enzyme_M PF00205.17 KOO29697.1 - 0.034 13.8 2.2 0.11 12.3 0.5 2.7 2 1 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Rz1 PF06085.6 KOO29697.1 - 6.3 6.2 10.0 16 5.0 6.9 1.6 1 0 0 1 1 1 0 Lipoprotein Rz1 precursor TPR_11 PF13414.1 KOO29698.1 - 1.2e-09 37.6 0.1 8.3e-06 25.3 0.0 3.1 2 1 1 3 3 3 2 TPR repeat TPR_2 PF07719.12 KOO29698.1 - 1.5e-07 30.7 0.1 0.15 12.0 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO29698.1 - 7.1e-05 22.2 0.0 1.2 8.8 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO29698.1 - 0.0018 18.7 0.2 2.7 8.8 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOO29698.1 - 0.012 15.5 0.1 0.073 13.0 0.1 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 KOO29698.1 - 0.048 14.3 0.3 4.4 8.0 0.0 3.5 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.1 KOO29698.1 - 0.099 12.8 0.0 12 6.4 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat NPR2 PF06218.6 KOO29699.1 - 1e-41 143.0 0.0 1.4e-41 142.6 0.0 1.1 1 0 0 1 1 1 1 Nitrogen permease regulator 2 MarR_2 PF12802.2 KOO29699.1 - 0.043 13.4 1.2 0.091 12.4 0.1 2.1 2 0 0 2 2 2 0 MarR family Fez1 PF06818.10 KOO29700.1 - 0.0031 17.5 9.3 0.0091 16.0 0.1 2.2 2 0 0 2 2 2 1 Fez1 DUF2944 PF11161.3 KOO29700.1 - 0.098 12.3 0.4 0.53 9.9 0.1 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2946) ATP-synt_E PF05680.7 KOO29700.1 - 0.098 12.6 8.4 1.3 9.0 0.1 2.4 2 0 0 2 2 2 0 ATP synthase E chain Sds3 PF08598.6 KOO29700.1 - 0.11 12.0 5.6 0.19 11.2 3.9 1.4 1 1 0 1 1 1 0 Sds3-like Peptidase_S49_N PF08496.5 KOO29700.1 - 2 8.2 6.9 0.64 9.7 1.8 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal WD40 PF00400.27 KOO29701.1 - 3.1e-82 267.7 20.3 2.3e-12 46.2 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 KOO29701.1 - 1.2e-07 30.3 10.7 0.0076 14.4 0.3 4.4 1 1 3 4 4 4 3 Nucleoporin Nup120/160 eIF2A PF08662.6 KOO29701.1 - 0.001 18.8 0.0 0.22 11.2 0.0 3.1 1 1 3 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.6 KOO29701.1 - 0.0023 16.7 0.3 0.38 9.4 0.1 2.5 1 1 2 3 3 3 2 Nup133 N terminal like Gmad1 PF10647.4 KOO29701.1 - 0.005 16.2 3.6 0.27 10.6 0.1 3.4 2 1 3 5 5 5 1 Lipoprotein LpqB beta-propeller domain Nbas_N PF15492.1 KOO29701.1 - 0.0064 15.6 1.3 1.2 8.1 0.1 3.5 1 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.7 KOO29701.1 - 0.02 14.5 1.4 31 4.3 0.0 3.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.11 KOO29701.1 - 0.044 12.0 0.0 0.61 8.3 0.0 2.3 1 1 1 2 2 2 0 Cytochrome D1 heme domain Apc4_WD40 PF12894.2 KOO29701.1 - 0.13 11.8 0.0 14 5.2 0.0 3.3 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Proteasome_A_N PF10584.4 KOO29701.1 - 4.2 6.7 9.1 0.9 8.9 0.1 3.5 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Filamin PF00630.14 KOO29702.1 - 1.7e-72 240.3 0.0 2.2e-17 63.4 0.0 9.2 9 1 0 9 9 9 7 Filamin/ABP280 repeat YtkA PF13115.1 KOO29702.1 - 0.0013 19.0 0.0 28 5.1 0.0 5.1 6 0 0 6 6 6 1 YtkA-like Y_Y_Y PF07495.8 KOO29702.1 - 0.069 12.9 0.0 16 5.3 0.0 3.5 3 0 0 3 3 3 0 Y_Y_Y domain Big_3_4 PF13754.1 KOO29702.1 - 1.6 9.0 13.1 5.9 7.2 0.0 6.9 8 0 0 8 8 8 0 Bacterial Ig-like domain (group 3) Kelch_4 PF13418.1 KOO29704.1 - 2.2e-27 94.5 9.5 8.5e-11 41.4 0.1 6.0 6 0 0 6 6 6 5 Galactose oxidase, central domain EGF_2 PF07974.8 KOO29704.1 - 1.8e-26 91.9 232.5 7.7e-05 22.7 8.2 13.1 13 0 0 13 13 13 12 EGF-like domain Kelch_3 PF13415.1 KOO29704.1 - 1.1e-24 85.8 24.9 4.2e-08 33.1 0.1 7.4 8 0 0 8 8 8 5 Galactose oxidase, central domain Kelch_6 PF13964.1 KOO29704.1 - 1e-18 66.6 3.6 0.003 17.6 0.1 5.7 3 1 2 5 5 5 5 Kelch motif Kelch_1 PF01344.20 KOO29704.1 - 8.6e-15 54.0 6.4 0.02 14.4 0.1 6.5 7 0 0 7 7 7 4 Kelch motif Kelch_5 PF13854.1 KOO29704.1 - 9.9e-15 54.1 0.6 0.004 17.0 0.0 5.3 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.10 KOO29704.1 - 1.9e-13 49.6 0.1 0.43 10.4 0.0 6.1 5 0 0 5 5 5 5 Kelch motif hEGF PF12661.2 KOO29704.1 - 0.0036 17.2 106.3 0.013 15.5 1.4 13.2 12 0 0 12 12 12 8 Human growth factor-like EGF EGF PF00008.22 KOO29704.1 - 4.3 7.4 169.5 0.064 13.2 4.0 12.9 12 0 0 12 12 12 0 EGF-like domain EGF_2 PF07974.8 KOO29705.1 - 1.9e-37 127.0 292.4 0.00011 22.3 8.2 15.7 15 0 0 15 15 15 15 EGF-like domain Kelch_4 PF13418.1 KOO29705.1 - 2.7e-29 100.6 10.6 1.2e-10 40.9 0.1 6.8 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.1 KOO29705.1 - 7.4e-22 76.9 33.7 5.8e-08 32.6 0.1 8.8 10 0 0 10 10 10 5 Galactose oxidase, central domain Kelch_6 PF13964.1 KOO29705.1 - 6.3e-18 64.1 4.5 0.0041 17.2 0.1 6.1 3 1 2 5 5 5 5 Kelch motif Kelch_5 PF13854.1 KOO29705.1 - 3.5e-14 52.3 0.6 0.0055 16.6 0.0 5.4 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.10 KOO29705.1 - 8.1e-13 47.5 0.6 0.6 9.9 0.0 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.20 KOO29705.1 - 5.4e-11 41.8 20.0 0.027 13.9 0.1 8.0 9 0 0 9 9 9 4 Kelch motif hEGF PF12661.2 KOO29705.1 - 0.0087 16.0 11.7 0.012 15.6 1.6 16.0 15 0 0 15 15 15 9 Human growth factor-like EGF HSP70 PF00012.15 KOO29706.1 - 2.8e-94 316.1 11.8 2.9e-88 296.3 3.2 2.9 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 KOO29706.1 - 1.2e-06 27.4 0.0 0.0061 15.2 0.0 2.7 1 1 0 2 2 2 2 MreB/Mbl protein WW PF00397.21 KOO29708.1 - 1.8e-24 85.2 5.6 7.2e-12 44.9 0.9 2.6 2 0 0 2 2 2 2 WW domain BAR PF03114.13 KOO29708.1 - 5.2e-12 45.7 0.4 9.3e-12 44.9 0.3 1.4 1 1 0 1 1 1 1 BAR domain SH3_2 PF07653.12 KOO29708.1 - 1.3e-09 37.3 0.0 2.7e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 KOO29708.1 - 1.8e-08 33.8 0.1 8.8e-08 31.6 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.23 KOO29708.1 - 2.4e-05 23.6 0.6 0.00012 21.4 0.0 2.5 3 0 0 3 3 3 1 SH3 domain Arfaptin PF06456.8 KOO29708.1 - 0.053 12.8 0.1 0.12 11.7 0.0 1.5 2 0 0 2 2 2 0 Arfaptin-like domain Aldedh PF00171.17 KOO29709.1 - 1.8e-157 524.4 0.3 2.1e-157 524.2 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family AAA PF00004.24 KOO29710.1 - 5.1e-15 55.8 0.0 9.8e-15 54.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 KOO29710.1 - 3.9e-12 46.1 0.0 1.8e-11 43.9 0.0 1.9 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.6 KOO29710.1 - 1.1e-11 44.5 0.0 2.6e-11 43.3 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA_22 PF13401.1 KOO29710.1 - 1.5e-06 28.3 0.0 1.6e-05 25.0 0.0 2.4 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.1 KOO29710.1 - 8.7e-06 25.8 0.1 0.019 14.9 0.0 3.3 2 2 2 4 4 4 1 AAA ATPase domain AAA_19 PF13245.1 KOO29710.1 - 1.1e-05 25.1 0.0 2.4e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain Rad17 PF03215.10 KOO29710.1 - 2.3e-05 23.2 0.0 0.00069 18.4 0.0 2.1 1 1 0 2 2 2 1 Rad17 cell cycle checkpoint protein AAA_30 PF13604.1 KOO29710.1 - 2.9e-05 23.7 0.0 8.5e-05 22.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.7 KOO29710.1 - 8.7e-05 21.6 0.0 0.00091 18.3 0.0 2.4 3 0 0 3 3 3 1 Holliday junction DNA helicase ruvB N-terminus AAA_24 PF13479.1 KOO29710.1 - 0.00041 19.9 0.0 0.001 18.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.1 KOO29710.1 - 0.00063 19.3 0.0 0.00094 18.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.4 KOO29710.1 - 0.0011 18.0 0.0 0.0016 17.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.1 KOO29710.1 - 0.0018 18.2 0.0 0.003 17.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 KOO29710.1 - 0.0021 17.8 0.0 0.0034 17.1 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase DNA_pol3_gamma3 PF12169.3 KOO29710.1 - 0.0026 17.5 3.0 0.36 10.5 0.2 2.9 2 1 1 3 3 3 2 DNA polymerase III subunits gamma and tau domain III AAA_5 PF07728.9 KOO29710.1 - 0.0031 17.2 0.0 0.013 15.2 0.0 2.0 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_10 PF12846.2 KOO29710.1 - 0.019 14.4 0.0 0.17 11.2 0.0 2.2 1 1 1 2 2 2 0 AAA-like domain ResIII PF04851.10 KOO29710.1 - 0.029 14.2 0.0 0.056 13.2 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Mg_chelatase PF01078.16 KOO29710.1 - 0.029 13.5 0.0 0.58 9.2 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 KOO29710.1 - 0.048 13.0 0.0 0.13 11.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain FtsQ PF03799.10 KOO29710.1 - 0.058 13.5 0.0 0.27 11.4 0.0 2.1 2 0 0 2 2 2 0 Cell division protein FtsQ DEAD PF00270.24 KOO29710.1 - 0.058 12.8 0.1 1.2 8.5 0.0 2.3 1 1 0 2 2 2 0 DEAD/DEAH box helicase PhoH PF02562.11 KOO29710.1 - 0.096 11.9 0.0 1.3 8.1 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein DUF815 PF05673.8 KOO29710.1 - 0.1 11.5 0.0 0.19 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_17 PF13207.1 KOO29710.1 - 0.13 13.0 0.0 0.28 12.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain Peptidase_S8 PF00082.17 KOO29711.1 - 9.6e-14 51.1 6.3 4.5e-07 29.3 0.3 3.1 2 1 1 3 3 3 2 Subtilase family Pyrophosphatase PF00719.14 KOO29712.1 - 1.2e-46 158.0 0.0 2.2e-46 157.1 0.0 1.5 1 0 0 1 1 1 1 Inorganic pyrophosphatase DIOX_N PF14226.1 KOO29713.1 - 8.6e-18 64.9 0.0 1e-17 64.7 0.0 1.1 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal EF-hand_1 PF00036.27 KOO29714.1 - 0.00055 19.0 0.2 0.047 13.0 0.3 2.7 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO29714.1 - 0.0012 18.9 1.7 0.0015 18.6 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO29714.1 - 0.0041 16.8 1.1 0.027 14.3 0.3 2.6 2 0 0 2 2 2 1 EF-hand domain CDC45 PF02724.9 KOO29714.1 - 0.0071 14.4 0.4 0.0078 14.2 0.3 1.1 1 0 0 1 1 1 1 CDC45-like protein EF-hand_8 PF13833.1 KOO29714.1 - 0.016 14.8 5.5 0.02 14.5 0.0 3.0 2 1 1 3 3 3 0 EF-hand domain pair Stimulus_sens_1 PF13756.1 KOO29714.1 - 0.043 14.2 0.3 5.1 7.5 0.0 2.4 2 0 0 2 2 2 0 Stimulus-sensing domain EF-hand_9 PF14658.1 KOO29714.1 - 0.078 12.8 8.2 0.17 11.8 0.0 2.9 3 0 0 3 3 3 0 EF-hand domain WD40 PF00400.27 KOO29719.1 - 4.1e-82 267.3 41.0 6.4e-12 44.8 0.3 9.4 8 1 1 9 9 9 9 WD domain, G-beta repeat PD40 PF07676.7 KOO29719.1 - 5.6e-18 64.1 11.7 0.14 11.8 0.0 8.7 9 0 0 9 9 9 6 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOO29719.1 - 8.4e-12 45.2 0.2 0.011 15.3 0.0 3.7 2 1 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A Gmad1 PF10647.4 KOO29719.1 - 7e-07 28.8 3.2 0.91 8.8 0.0 5.7 3 3 2 5 5 5 2 Lipoprotein LpqB beta-propeller domain DUF3312 PF11768.3 KOO29719.1 - 9.1e-07 27.4 0.0 0.13 10.4 0.0 3.5 1 1 4 5 5 5 5 Protein of unknown function (DUF3312) Nucleoporin_N PF08801.6 KOO29719.1 - 0.001 17.9 6.7 0.92 8.1 0.3 4.0 1 1 3 4 4 4 2 Nup133 N terminal like DUF4467 PF14729.1 KOO29719.1 - 0.021 15.1 0.0 49 4.3 0.0 3.5 2 1 1 3 3 3 0 Domain of unknown function with cystatin-like fold (DUF4467) eIF-5a PF01287.15 KOO29720.1 - 4.3e-20 71.4 0.0 6.3e-20 70.8 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.7 KOO29720.1 - 0.00029 20.6 0.5 0.00065 19.5 0.0 1.8 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain KOW PF00467.24 KOO29720.1 - 0.003 17.1 0.1 0.0053 16.4 0.1 1.4 1 0 0 1 1 1 1 KOW motif EF-hand_5 PF13202.1 KOO29720.1 - 0.014 14.7 0.1 0.03 13.6 0.1 1.5 1 0 0 1 1 1 0 EF hand SAM_1 PF00536.25 KOO29721.1 - 4.4e-07 29.9 0.0 7.6e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 KOO29721.1 - 7e-07 29.0 0.0 1.6e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_9 PF14604.1 KOO29721.1 - 0.00022 20.7 0.0 0.00036 20.0 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain LRR_6 PF13516.1 KOO29721.1 - 0.00024 20.8 20.4 0.75 10.0 0.0 9.0 10 0 0 10 10 10 2 Leucine Rich repeat SH3_1 PF00018.23 KOO29721.1 - 0.061 12.7 0.0 0.099 12.0 0.0 1.3 1 0 0 1 1 1 0 SH3 domain SH3_2 PF07653.12 KOO29721.1 - 0.2 11.1 0.0 0.32 10.5 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain EF-hand_1 PF00036.27 KOO29722.1 - 2.7e-05 23.1 0.0 3.8e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 KOO29722.1 - 0.00012 21.5 0.0 0.00016 21.2 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO29722.1 - 0.00016 21.2 0.0 0.00022 20.8 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.1 KOO29722.1 - 0.0016 17.6 0.0 0.0025 17.0 0.0 1.3 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO29722.1 - 0.003 17.6 0.0 0.0037 17.3 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO29725.1 - 5.8e-32 106.5 8.6 2.3e-05 23.3 0.2 9.1 10 0 0 10 10 10 6 EF hand EF-hand_6 PF13405.1 KOO29725.1 - 2.2e-29 98.6 6.4 0.00084 19.0 0.0 9.0 9 0 0 9 9 9 6 EF-hand domain EF-hand_7 PF13499.1 KOO29725.1 - 1.6e-25 88.9 10.2 1.4e-07 31.5 0.0 6.6 5 2 3 8 8 8 7 EF-hand domain pair EF-hand_5 PF13202.1 KOO29725.1 - 1.2e-22 78.2 13.8 7.9e-06 24.9 0.0 7.4 7 0 0 7 7 7 4 EF hand EF-hand_8 PF13833.1 KOO29725.1 - 3.6e-18 64.9 10.5 0.00059 19.4 0.0 7.3 5 2 2 7 7 7 5 EF-hand domain pair EF-hand_4 PF12763.2 KOO29725.1 - 0.0002 21.0 3.0 0.06 13.0 0.0 3.7 3 1 1 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO29725.1 - 0.0021 17.9 0.0 48 3.9 0.0 5.7 8 0 0 8 8 8 0 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO29725.1 - 0.0026 17.7 0.6 13 5.8 0.0 4.1 4 1 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region RST PF12174.3 KOO29725.1 - 0.014 15.1 0.0 3.1 7.6 0.0 3.1 3 0 0 3 3 3 0 RCD1-SRO-TAF4 (RST) plant domain Dockerin_1 PF00404.13 KOO29725.1 - 2.5 7.9 4.7 28 4.6 0.1 2.7 2 0 0 2 2 2 0 Dockerin type I repeat AAA PF00004.24 KOO29726.1 - 1.4e-40 138.5 0.2 8.9e-17 61.5 0.0 4.9 5 0 0 5 5 5 3 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 KOO29726.1 - 1.4e-15 57.0 0.2 4e-05 22.7 0.0 5.0 3 2 0 3 3 3 3 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KOO29726.1 - 1.2e-14 54.5 4.5 0.13 12.4 0.0 6.7 3 3 2 5 5 5 4 AAA domain AAA_19 PF13245.1 KOO29726.1 - 2.9e-11 42.9 4.8 0.0018 17.9 0.0 4.9 5 0 0 5 5 3 3 Part of AAA domain AAA_17 PF13207.1 KOO29726.1 - 4.2e-11 43.7 1.5 0.045 14.5 0.1 4.1 4 0 0 4 4 3 3 AAA domain Mg_chelatase PF01078.16 KOO29726.1 - 2.4e-10 39.9 2.4 0.033 13.3 0.0 4.9 3 2 2 5 5 5 3 Magnesium chelatase, subunit ChlI AAA_18 PF13238.1 KOO29726.1 - 2.5e-08 34.2 2.2 0.059 13.6 0.0 3.8 3 0 0 3 3 3 3 AAA domain AAA_16 PF13191.1 KOO29726.1 - 7.5e-08 32.5 4.8 0.082 12.8 0.0 4.4 4 1 0 4 4 3 2 AAA ATPase domain AAA_5 PF07728.9 KOO29726.1 - 1.8e-07 30.9 3.0 0.18 11.5 0.0 4.3 4 1 0 4 4 3 3 AAA domain (dynein-related subfamily) AAA_28 PF13521.1 KOO29726.1 - 3.6e-07 30.2 2.0 0.018 14.9 0.0 4.2 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.12 KOO29726.1 - 6.2e-07 28.9 0.9 0.045 13.1 0.0 3.6 3 0 0 3 3 3 2 IstB-like ATP binding protein Viral_helicase1 PF01443.13 KOO29726.1 - 9.9e-07 28.5 0.2 0.55 9.7 0.0 3.5 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.21 KOO29726.1 - 1.8e-06 27.5 3.2 0.06 12.8 0.1 5.4 3 2 0 3 3 3 1 Sigma-54 interaction domain AAA_33 PF13671.1 KOO29726.1 - 5.2e-06 26.3 3.5 0.093 12.5 0.0 4.4 4 0 0 4 4 4 1 AAA domain KTI12 PF08433.5 KOO29726.1 - 1.3e-05 24.5 0.1 0.32 10.1 0.0 3.3 3 0 0 3 3 3 2 Chromatin associated protein KTI12 RNA_helicase PF00910.17 KOO29726.1 - 1.4e-05 25.2 0.2 1.9 8.7 0.0 3.6 3 0 0 3 3 3 1 RNA helicase AAA_2 PF07724.9 KOO29726.1 - 2.2e-05 24.4 0.1 0.46 10.3 0.0 3.5 3 0 0 3 3 3 2 AAA domain (Cdc48 subfamily) AAA_10 PF12846.2 KOO29726.1 - 2.5e-05 23.8 0.2 0.17 11.2 0.0 4.0 4 0 0 4 4 4 1 AAA-like domain AAA_30 PF13604.1 KOO29726.1 - 2.6e-05 23.8 4.3 0.5 9.9 0.1 4.6 3 2 0 3 3 3 1 AAA domain AAA_24 PF13479.1 KOO29726.1 - 3.8e-05 23.3 3.5 0.71 9.4 0.1 3.5 3 0 0 3 3 3 1 AAA domain MobB PF03205.9 KOO29726.1 - 4.1e-05 23.3 1.0 1.9 8.2 0.0 3.7 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.22 KOO29726.1 - 4.8e-05 23.6 1.6 5.7 7.2 0.1 3.8 3 0 0 3 3 3 0 ABC transporter Sigma54_activ_2 PF14532.1 KOO29726.1 - 5.3e-05 23.2 0.3 0.99 9.4 0.0 4.3 4 0 0 4 4 4 1 Sigma-54 interaction domain AAA_11 PF13086.1 KOO29726.1 - 5.8e-05 22.7 0.1 0.39 10.2 0.0 4.2 3 2 0 3 3 3 1 AAA domain AAA_3 PF07726.6 KOO29726.1 - 0.00026 20.5 0.0 2.3 7.8 0.0 3.6 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 KOO29726.1 - 0.0014 18.1 0.9 3.4 7.0 0.2 4.0 3 1 0 3 3 3 0 AAA domain Zeta_toxin PF06414.7 KOO29726.1 - 0.0021 17.2 0.0 1.9 7.5 0.0 3.6 3 0 0 3 3 3 1 Zeta toxin Torsin PF06309.6 KOO29726.1 - 0.0044 16.8 0.0 24 4.8 0.0 3.7 3 0 0 3 3 3 0 Torsin PRK PF00485.13 KOO29726.1 - 0.0057 16.2 0.1 1.1 8.7 0.0 3.0 3 0 0 3 3 3 1 Phosphoribulokinase / Uridine kinase family KaiC PF06745.8 KOO29726.1 - 0.0063 15.6 1.2 3.6 6.6 0.1 3.5 3 0 0 3 3 3 0 KaiC DUF815 PF05673.8 KOO29726.1 - 0.018 13.9 0.0 6.7 5.5 0.0 3.8 4 0 0 4 4 3 0 Protein of unknown function (DUF815) AAA_29 PF13555.1 KOO29726.1 - 0.019 14.5 0.1 4.4 6.9 0.0 3.4 3 0 0 3 3 3 0 P-loop containing region of AAA domain NTPase_1 PF03266.10 KOO29726.1 - 0.026 14.2 1.9 10 5.7 0.0 3.6 3 0 0 3 3 3 0 NTPase APS_kinase PF01583.15 KOO29726.1 - 0.034 13.7 0.5 14 5.3 0.0 3.8 4 0 0 4 4 4 0 Adenylylsulphate kinase TrwB_AAD_bind PF10412.4 KOO29726.1 - 0.047 12.3 0.9 1.6 7.3 0.0 2.8 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain DUF2075 PF09848.4 KOO29726.1 - 0.05 12.5 4.9 7.2 5.4 0.1 3.9 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) AAA_31 PF13614.1 KOO29726.1 - 0.06 13.2 0.1 8.1 6.3 0.0 3.5 5 0 0 5 5 3 0 AAA domain NACHT PF05729.7 KOO29726.1 - 0.085 12.5 3.2 6.9 6.3 0.0 3.6 3 0 0 3 3 3 0 NACHT domain Zot PF05707.7 KOO29726.1 - 0.12 11.7 3.0 62 2.9 0.0 4.9 3 2 1 4 4 4 0 Zonular occludens toxin (Zot) SRP54 PF00448.17 KOO29726.1 - 0.14 11.5 2.9 4.6 6.6 0.0 3.3 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain T2SE PF00437.15 KOO29726.1 - 0.15 10.9 0.4 1.3 7.8 0.0 2.6 3 0 0 3 3 3 0 Type II/IV secretion system protein SKI PF01202.17 KOO29726.1 - 0.17 11.7 6.7 2 8.2 0.0 3.8 4 0 0 4 4 3 0 Shikimate kinase AAA_23 PF13476.1 KOO29726.1 - 0.26 11.5 0.7 24 5.1 0.0 3.4 3 0 0 3 3 3 0 AAA domain Mur_ligase_M PF08245.7 KOO29726.1 - 0.32 11.0 1.8 51 3.8 0.1 3.7 4 0 0 4 4 4 0 Mur ligase middle domain TIP49 PF06068.8 KOO29726.1 - 0.34 9.5 4.1 5.5 5.5 0.0 4.2 5 1 1 6 6 6 0 TIP49 C-terminus Thymidylate_kin PF02223.12 KOO29726.1 - 0.35 10.2 3.3 20 4.4 0.0 3.5 3 0 0 3 3 3 0 Thymidylate kinase CbiA PF01656.18 KOO29726.1 - 1.1 8.6 5.0 0.85 8.9 0.0 2.8 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain ATP_bind_1 PF03029.12 KOO29726.1 - 1.7 8.1 3.7 4.2 6.8 0.1 3.0 3 1 0 3 3 3 0 Conserved hypothetical ATP binding protein THOC7 PF05615.8 KOO29728.1 - 0.081 13.1 4.8 0.73 10.1 2.1 2.5 2 0 0 2 2 2 0 Tho complex subunit 7 Chromo PF00385.19 KOO29730.1 - 3.3e-08 33.0 0.0 6.1e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Stc1 PF12898.2 KOO29730.1 - 8.5e-05 22.5 1.9 0.00017 21.5 1.3 1.5 1 0 0 1 1 1 1 Stc1 domain Pkinase PF00069.20 KOO29731.1 - 3e-37 128.1 0.0 5.4e-37 127.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29731.1 - 4.1e-17 62.1 0.1 6.8e-17 61.3 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO29731.1 - 0.0093 14.9 0.0 0.016 14.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 KOO29731.1 - 0.043 13.1 0.0 0.099 11.9 0.0 1.7 1 0 0 1 1 1 0 RIO1 family APH PF01636.18 KOO29731.1 - 0.051 13.3 0.2 0.19 11.4 0.0 1.9 2 1 1 3 3 3 0 Phosphotransferase enzyme family CcdA PF07362.7 KOO29732.1 - 0.19 11.6 4.4 0.35 10.7 3.0 1.6 1 0 0 1 1 1 0 Post-segregation antitoxin CcdA TerB-N PF13208.1 KOO29732.1 - 1.1 8.6 4.7 1.6 8.0 3.2 1.2 1 0 0 1 1 1 0 TerB-N Amidohydro_1 PF01979.15 KOO29733.1 - 0.00011 22.0 0.2 0.00016 21.4 0.1 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_5 PF13594.1 KOO29733.1 - 0.0036 17.0 0.1 0.011 15.4 0.0 1.9 2 0 0 2 2 2 1 Amidohydrolase Brix PF04427.13 KOO29736.1 - 7.2e-30 104.0 0.0 9.4e-30 103.6 0.0 1.1 1 0 0 1 1 1 1 Brix domain Mqo PF06039.10 KOO29739.1 - 1.3e-179 597.4 0.0 8.4e-179 594.8 0.0 1.8 1 1 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) DAO PF01266.19 KOO29739.1 - 1.6e-11 43.6 0.0 2.3e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.19 KOO29740.1 - 1.9e-48 165.2 1.5 2.9e-48 164.6 1.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GCV_T PF01571.16 KOO29740.1 - 4.9e-34 117.5 0.0 1.3e-33 116.2 0.0 1.6 2 0 0 2 2 2 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 KOO29740.1 - 9.3e-06 25.5 0.0 2.7e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Pyr_redox_2 PF07992.9 KOO29740.1 - 7.7e-05 22.6 1.9 0.002 18.0 1.3 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 KOO29740.1 - 0.00015 20.9 0.3 0.0003 19.9 0.0 1.5 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase HI0933_like PF03486.9 KOO29740.1 - 0.00059 18.4 4.1 0.15 10.5 0.0 2.2 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_3 PF13738.1 KOO29740.1 - 0.0025 17.9 0.3 0.37 10.8 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 KOO29740.1 - 0.0031 17.5 2.7 0.0082 16.1 1.9 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 KOO29740.1 - 0.0042 16.1 3.9 0.048 12.7 1.5 2.2 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.7 KOO29740.1 - 0.0058 15.5 3.4 0.88 8.4 1.2 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein GIDA PF01134.17 KOO29740.1 - 0.0078 15.1 1.4 0.032 13.1 0.4 2.0 2 0 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_9 PF13454.1 KOO29740.1 - 0.0089 15.8 4.8 0.66 9.7 0.1 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding 3HCDH_N PF02737.13 KOO29740.1 - 0.011 15.3 0.3 0.02 14.5 0.2 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_10 PF13460.1 KOO29740.1 - 0.018 15.0 6.7 2.2 8.2 2.8 3.5 2 1 0 2 2 2 0 NADH(P)-binding Pyr_redox PF00070.22 KOO29740.1 - 0.093 13.1 2.0 0.42 11.0 0.9 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 KOO29740.1 - 0.72 8.4 2.3 20 3.6 0.0 2.2 2 0 0 2 2 2 0 Tryptophan halogenase tRNA_U5-meth_tr PF05958.6 KOO29742.1 - 1.3e-13 50.3 0.0 2.5e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.1 KOO29742.1 - 3.9e-12 46.0 0.0 5.9e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOO29742.1 - 6.5e-07 28.8 1.7 7.2e-07 28.7 0.3 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_26 PF13659.1 KOO29742.1 - 8.4e-07 29.0 0.8 8.4e-07 29.0 0.6 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO29742.1 - 1.4e-06 28.8 0.6 4.8e-06 27.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.1 KOO29742.1 - 2.1e-05 24.2 0.2 0.00018 21.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.12 KOO29742.1 - 0.00021 20.4 0.0 0.00035 19.6 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.8 KOO29742.1 - 0.00026 20.2 0.2 0.00061 19.0 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.13 KOO29742.1 - 0.00098 18.7 0.2 0.0018 17.8 0.1 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.1 KOO29742.1 - 0.0011 19.3 0.0 0.0036 17.6 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Cons_hypoth95 PF03602.10 KOO29742.1 - 0.002 17.5 0.0 0.0033 16.8 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.7 KOO29742.1 - 0.0039 17.6 0.0 0.017 15.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain RRM_6 PF14259.1 KOO29742.1 - 0.0074 16.2 0.0 0.016 15.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Ubie_methyltran PF01209.13 KOO29742.1 - 0.01 14.9 0.0 0.017 14.2 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family RRM_1 PF00076.17 KOO29742.1 - 0.016 14.8 0.0 0.026 14.1 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Methyltransf_15 PF09445.5 KOO29742.1 - 0.061 12.8 0.0 0.093 12.2 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase RRM_5 PF13893.1 KOO29742.1 - 0.097 12.5 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Methyltransf_23 PF13489.1 KOO29742.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.14 KOO29742.1 - 0.11 11.9 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ring_hydroxyl_A PF00848.14 KOO29743.1 - 3.9e-40 137.7 0.0 6.6e-40 137.0 0.0 1.3 1 0 0 1 1 1 1 Ring hydroxylating alpha subunit (catalytic domain) Rieske PF00355.21 KOO29743.1 - 4e-18 64.7 0.0 6.9e-18 64.0 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Galactosyl_T PF01762.16 KOO29746.1 - 1.7e-17 63.6 0.0 2.8e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.11 KOO29746.1 - 0.029 13.5 0.0 0.037 13.2 0.0 1.2 1 0 0 1 1 1 0 Fringe-like SSF PF00474.12 KOO29747.1 - 1.2e-13 50.4 32.0 6.2e-13 48.1 22.2 2.0 1 1 0 1 1 1 1 Sodium:solute symporter family DUF221 PF02714.10 KOO29748.1 - 2.5e-07 29.8 11.6 0.0008 18.3 1.5 2.7 3 0 0 3 3 3 2 Domain of unknown function DUF221 Corona_S2 PF01601.11 KOO29748.1 - 0.33 8.9 3.1 0.69 7.9 2.2 1.4 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Anoctamin PF04547.7 KOO29748.1 - 1.6 7.3 4.9 0.37 9.3 0.1 2.1 1 1 0 2 2 2 0 Calcium-activated chloride channel DUF4145 PF13643.1 KOO29749.1 - 0.12 12.2 0.3 1.3 8.8 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4145) Usp PF00582.21 KOO29750.1 - 1.5e-08 34.9 1.9 0.0026 17.9 0.6 2.8 2 1 0 2 2 2 2 Universal stress protein family PX PF00787.19 KOO29752.1 - 3.4e-06 26.8 0.0 5.1e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 PX domain GATA PF00320.22 KOO29755.1 - 2.6e-17 61.8 25.4 1e-05 24.7 3.2 6.5 6 0 0 6 6 6 4 GATA zinc finger zf-C2H2_6 PF13912.1 KOO29755.1 - 4.5e-10 39.0 41.2 0.0045 16.8 0.2 7.9 8 0 0 8 8 8 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KOO29755.1 - 0.001 19.1 5.2 20 5.4 0.0 6.3 7 0 0 7 7 7 1 Zinc-finger double-stranded RNA-binding WHIM2 PF15613.1 KOO29755.1 - 0.0038 17.1 0.0 0.23 11.4 0.0 3.2 3 0 0 3 3 3 1 WSTF, HB1, Itc1p, MBD9 motif 2 Trm112p PF03966.11 KOO29755.1 - 0.0075 16.6 5.9 0.17 12.2 0.9 4.4 3 0 0 3 3 3 1 Trm112p-like protein WHIM3 PF15614.1 KOO29755.1 - 0.02 14.6 0.1 0.07 12.9 0.1 1.9 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 3 zinc-ribbons_6 PF07191.7 KOO29755.1 - 1.5 8.6 39.5 0.38 10.5 0.2 7.2 3 2 2 5 5 5 0 zinc-ribbons DUF4440 PF14534.1 KOO29756.1 - 1.1e-05 25.6 1.4 0.14 12.3 0.0 3.9 3 1 0 3 3 3 2 Domain of unknown function (DUF4440) CSD PF00313.17 KOO29756.1 - 0.00019 21.1 2.1 7.2 6.4 0.0 3.7 3 0 0 3 3 3 3 'Cold-shock' DNA-binding domain SnoaL_2 PF12680.2 KOO29756.1 - 0.043 14.2 3.3 0.71 10.3 0.0 3.3 4 1 0 4 4 4 0 SnoaL-like domain RPAP3_C PF13877.1 KOO29757.1 - 7.6e-13 48.2 0.0 1.7e-12 47.1 0.0 1.6 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 TPR_11 PF13414.1 KOO29757.1 - 3e-10 39.5 11.4 3.7e-06 26.4 2.0 2.7 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 KOO29757.1 - 7.4e-05 22.3 11.8 0.009 15.8 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO29757.1 - 0.00027 20.3 8.1 0.021 14.4 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO29757.1 - 0.00039 21.0 7.5 0.00039 21.0 5.2 5.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO29757.1 - 0.00068 20.0 4.2 0.00068 20.0 2.9 5.8 5 2 2 7 7 7 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO29757.1 - 0.02 15.0 0.0 0.094 12.9 0.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO29757.1 - 0.05 14.0 4.4 0.66 10.5 0.1 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO29757.1 - 0.072 13.0 8.3 0.42 10.5 1.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO29757.1 - 0.19 11.5 12.6 0.16 11.8 4.5 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat ABC_tran PF00005.22 KOO29758.1 - 7e-30 104.1 0.0 1.1e-29 103.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 KOO29758.1 - 2.6e-11 43.4 0.0 3.5e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.14 KOO29758.1 - 1.9e-07 30.5 0.0 2e-05 23.9 0.0 2.0 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 KOO29758.1 - 3e-05 24.1 0.1 0.23 11.3 0.0 2.1 1 1 0 2 2 2 2 AAA domain AAA_17 PF13207.1 KOO29758.1 - 8.4e-05 23.3 0.0 0.00013 22.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 KOO29758.1 - 9.8e-05 21.8 1.1 0.00046 19.6 0.8 2.1 1 1 0 1 1 1 1 AAA domain CbiA PF01656.18 KOO29758.1 - 0.00022 20.6 0.1 0.00036 19.9 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_29 PF13555.1 KOO29758.1 - 0.00023 20.6 0.1 0.00052 19.4 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.1 KOO29758.1 - 0.00048 20.1 1.9 0.0011 19.0 1.3 1.5 1 0 0 1 1 1 1 AAA ATPase domain DUF87 PF01935.12 KOO29758.1 - 0.0077 16.0 0.1 0.018 14.8 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function DUF87 Mg_chelatase PF01078.16 KOO29758.1 - 0.016 14.4 0.0 0.028 13.6 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI SRP54 PF00448.17 KOO29758.1 - 0.025 14.0 0.0 0.044 13.2 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_18 PF13238.1 KOO29758.1 - 0.028 14.7 0.1 0.051 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 KOO29758.1 - 0.046 13.4 0.1 0.15 11.7 0.1 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.1 KOO29758.1 - 0.062 13.2 0.1 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 KOO29758.1 - 0.074 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_33 PF13671.1 KOO29758.1 - 0.083 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 KOO29758.1 - 0.089 11.9 0.0 0.17 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 NACHT PF05729.7 KOO29758.1 - 0.13 11.9 0.2 1.7 8.3 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_22 PF13401.1 KOO29758.1 - 0.15 12.2 0.2 0.81 9.8 0.2 2.1 1 1 0 1 1 1 0 AAA domain Vac14_Fig4_bd PF11916.3 KOO29760.1 - 8.9e-69 230.2 1.5 1.4e-68 229.5 0.2 2.0 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.2 KOO29760.1 - 1.5e-44 150.2 0.1 2.8e-37 126.9 0.1 4.1 4 0 0 4 4 4 2 Vacuolar 14 Fab1-binding region HEAT PF02985.17 KOO29760.1 - 2.1e-11 42.8 0.3 0.064 13.3 0.0 7.4 7 0 0 7 7 7 2 HEAT repeat HEAT_2 PF13646.1 KOO29760.1 - 4.7e-10 39.6 3.0 0.003 17.8 0.0 5.0 3 1 1 4 4 4 3 HEAT repeats HEAT_EZ PF13513.1 KOO29760.1 - 7.4e-06 26.2 6.5 0.28 11.7 0.1 6.3 5 1 1 6 6 6 1 HEAT-like repeat CLASP_N PF12348.3 KOO29760.1 - 8.3e-05 22.0 2.3 0.31 10.3 1.5 3.7 1 1 3 4 4 4 3 CLASP N terminal Cnd1 PF12717.2 KOO29760.1 - 0.0012 18.6 0.8 0.43 10.4 0.1 4.0 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Xpo1 PF08389.7 KOO29760.1 - 0.0019 18.1 5.2 0.81 9.5 0.0 4.6 4 1 1 5 5 5 1 Exportin 1-like protein DUF844 PF05815.6 KOO29760.1 - 0.0063 15.3 0.3 1.1 8.0 0.0 3.1 3 0 0 3 3 3 1 Baculovirus protein of unknown function (DUF844) DUF2435 PF10363.4 KOO29760.1 - 0.0066 16.3 0.7 0.037 13.9 0.0 2.7 3 0 0 3 3 2 1 Protein of unknown function (DUF2435) AAA_10 PF12846.2 KOO29760.1 - 0.01 15.3 0.1 3.5 6.9 0.0 2.5 2 1 0 2 2 2 0 AAA-like domain DUF2454 PF10521.4 KOO29760.1 - 0.013 14.4 0.0 3.8 6.4 0.0 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2454) Ipi1_N PF12333.3 KOO29760.1 - 0.077 12.9 3.8 0.56 10.2 1.5 3.3 3 1 0 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation UME PF08064.8 KOO29760.1 - 0.11 12.4 5.2 0.66 9.9 0.2 3.9 2 1 2 4 4 4 0 UME (NUC010) domain Ten1 PF12658.2 KOO29760.1 - 0.14 11.9 0.0 1.2 8.9 0.0 2.3 2 0 0 2 2 2 0 Telomere capping, CST complex subunit ThiF PF00899.16 KOO29761.1 - 8.2e-39 132.5 0.1 2.9e-38 130.7 0.0 1.8 2 0 0 2 2 2 1 ThiF family UBACT PF02134.16 KOO29761.1 - 8.6e-22 76.5 0.5 1.4e-21 75.8 0.3 1.3 1 0 0 1 1 1 1 Repeat in ubiquitin-activating (UBA) protein E2_bind PF08825.5 KOO29761.1 - 5.8e-12 45.1 0.0 1.1e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 E2 binding domain UBA_e1_thiolCys PF10585.4 KOO29761.1 - 3.4e-11 42.3 3.2 5.9e-11 41.5 2.2 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site MoeZ_MoeB PF05237.8 KOO29761.1 - 0.00061 19.3 0.1 0.00061 19.3 0.0 1.9 2 0 0 2 2 2 1 MoeZ/MoeB domain Shikimate_DH PF01488.15 KOO29761.1 - 0.096 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase c-SKI_SMAD_bind PF08782.5 KOO29761.1 - 0.31 11.2 1.3 0.91 9.6 0.0 2.1 2 0 0 2 2 2 0 c-SKI Smad4 binding domain WD40 PF00400.27 KOO29762.1 - 1e-07 31.5 0.0 0.2 11.6 0.0 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat TruB_C PF09142.6 KOO29762.1 - 3.1e-05 23.5 0.8 8.9 6.0 0.0 5.5 4 0 0 4 4 4 2 tRNA Pseudouridine synthase II, C terminal PQQ_3 PF13570.1 KOO29762.1 - 0.048 13.9 4.2 15 5.9 0.1 4.7 5 0 0 5 5 5 0 PQQ-like domain GBP_C PF02841.9 KOO29762.1 - 0.91 8.6 10.8 1.4 7.9 7.5 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain TACC PF05010.9 KOO29762.1 - 1.1 8.9 8.5 1.8 8.2 5.9 1.3 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) APG6 PF04111.7 KOO29762.1 - 3.6 6.5 11.3 6 5.8 7.8 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF3461 PF11944.3 KOO29763.1 - 0.28 11.0 1.5 5.2 6.9 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3461) Trichoplein PF13868.1 KOO29764.1 - 3.9e-16 58.4 96.4 3.9e-16 58.4 66.8 2.1 1 1 1 2 2 2 1 Tumour suppressor, Mitostatin PAS PF00989.19 KOO29764.1 - 7.4 6.4 12.2 0.11 12.2 0.3 3.1 3 0 0 3 3 3 0 PAS fold RVT_2 PF07727.9 KOO29765.1 - 2e-40 138.3 0.0 2.9e-39 134.5 0.0 2.5 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KOO29765.1 - 1.3e-09 38.1 0.0 4.4e-09 36.4 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.1 KOO29765.1 - 0.0033 17.0 0.2 0.0089 15.6 0.2 1.6 1 0 0 1 1 1 1 GAG-pre-integrase domain NACHT PF05729.7 KOO29767.1 - 5.3e-05 22.9 0.1 0.0004 20.0 0.1 2.3 1 1 0 1 1 1 1 NACHT domain AAA_19 PF13245.1 KOO29767.1 - 0.00058 19.5 0.1 0.0018 18.0 0.1 1.8 1 0 0 1 1 1 1 Part of AAA domain UvrD-helicase PF00580.16 KOO29767.1 - 0.092 12.0 1.7 0.15 11.3 0.0 2.1 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain G-alpha PF00503.15 KOO29768.1 - 1.3e-97 326.9 0.0 2.1e-97 326.2 0.0 1.3 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 KOO29768.1 - 3.7e-14 52.3 1.0 3.6e-11 42.5 0.1 2.8 2 0 0 2 2 2 2 ADP-ribosylation factor family Miro PF08477.8 KOO29768.1 - 0.11 13.0 1.0 5 7.6 0.0 2.7 2 0 0 2 2 2 0 Miro-like protein Gtr1_RagA PF04670.7 KOO29768.1 - 0.23 10.5 3.9 0.55 9.3 0.2 2.2 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Methyltrn_RNA_3 PF02598.12 KOO29769.1 - 4.8e-55 186.9 0.0 2.4e-32 112.4 0.0 2.0 1 1 1 2 2 2 2 Putative RNA methyltransferase SpoU_methylase PF00588.14 KOO29769.1 - 0.073 12.9 0.0 1 9.2 0.0 2.5 3 0 0 3 3 3 0 SpoU rRNA Methylase family Pro_isomerase PF00160.16 KOO29770.1 - 1e-42 145.9 0.3 1.2e-42 145.7 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Mito_carr PF00153.22 KOO29772.1 - 5.4e-25 86.9 2.3 1.8e-14 53.1 0.1 2.5 2 0 0 2 2 2 2 Mitochondrial carrier protein Arm PF00514.18 KOO29774.1 - 2.4 8.0 13.7 0.3 10.9 0.3 3.5 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO29774.1 - 3.5 7.9 16.6 0.38 11.0 6.4 2.6 1 1 1 2 2 2 0 HEAT repeats Kelch_1 PF01344.20 KOO29776.1 - 3.1e-94 308.3 0.1 7.5e-17 60.6 0.0 6.1 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.1 KOO29776.1 - 2.3e-61 201.5 0.0 1.6e-11 43.8 0.0 6.1 2 1 4 6 6 6 6 Kelch motif Kelch_2 PF07646.10 KOO29776.1 - 1.1e-52 173.8 0.0 2.9e-11 42.6 0.0 6.1 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.1 KOO29776.1 - 3e-48 161.0 1.9 8.2e-07 29.0 0.0 6.1 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.1 KOO29776.1 - 1.3e-47 159.3 0.0 2.6e-08 33.5 0.0 6.2 4 2 2 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO29776.1 - 9.9e-23 79.6 11.7 0.00015 21.6 0.0 6.7 7 0 0 7 7 7 6 Kelch motif PQQ_3 PF13570.1 KOO29776.1 - 1.3e-09 38.0 17.4 0.47 10.7 0.1 5.7 5 1 0 6 6 6 5 PQQ-like domain DUF721 PF05258.7 KOO29776.1 - 7e-08 32.5 0.0 0.3 11.3 0.0 4.5 4 1 1 5 5 5 2 Protein of unknown function (DUF721) Glyoxal_oxid_N PF07250.6 KOO29776.1 - 1e-07 31.2 0.0 0.028 13.4 0.0 3.9 1 1 2 3 3 3 2 Glyoxal oxidase N-terminus DUF134 PF02001.11 KOO29776.1 - 0.00024 20.9 0.0 3.6 7.5 0.0 4.7 5 0 0 5 5 5 1 Protein of unknown function DUF134 DUF1668 PF07893.8 KOO29776.1 - 0.0011 18.2 4.2 0.74 8.8 0.1 4.2 1 1 4 5 5 5 1 Protein of unknown function (DUF1668) Peptidase_S9_N PF02897.10 KOO29776.1 - 0.0058 15.2 0.0 0.39 9.2 0.0 2.2 1 1 1 2 2 2 1 Prolyl oligopeptidase, N-terminal beta-propeller domain DUF1396 PF07161.8 KOO29776.1 - 0.0094 15.6 0.8 4.5 6.8 0.0 3.9 2 1 3 5 5 5 1 Protein of unknown function (DUF1396) Rax2 PF12768.2 KOO29776.1 - 0.095 11.8 0.0 1 8.4 0.0 2.5 1 1 2 3 3 3 0 Cortical protein marker for cell polarity Ion_trans PF00520.26 KOO29777.1 - 6e-171 564.2 60.7 8.6e-46 155.7 5.3 4.2 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 KOO29777.1 - 3.7e-07 28.9 78.5 6.6e-05 21.5 4.7 10.0 9 1 1 10 10 10 8 Polycystin cation channel ISK_Channel PF02060.10 KOO29777.1 - 0.67 9.5 4.7 11 5.6 0.0 3.6 3 0 0 3 3 3 0 Slow voltage-gated potassium channel EF-hand_1 PF00036.27 KOO29779.1 - 1.2e-28 96.1 4.5 2.5e-06 26.3 0.0 5.4 5 0 0 5 5 5 5 EF hand EF-hand_6 PF13405.1 KOO29779.1 - 1e-26 90.3 7.3 3.9e-05 23.1 0.0 5.6 5 0 0 5 5 5 5 EF-hand domain EF-hand_7 PF13499.1 KOO29779.1 - 3.5e-23 81.5 15.9 4.5e-09 36.3 0.3 3.8 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO29779.1 - 1.9e-20 71.2 10.9 0.0011 18.2 0.1 5.5 5 0 0 5 5 5 5 EF hand EF-hand_8 PF13833.1 KOO29779.1 - 6.4e-19 67.3 4.3 2.5e-08 33.3 0.1 4.0 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO29779.1 - 0.00024 21.1 0.0 0.81 9.7 0.0 2.5 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region RHH_1 PF01402.16 KOO29779.1 - 0.013 15.4 3.2 0.2 11.6 0.1 3.1 3 0 0 3 3 3 0 Ribbon-helix-helix protein, copG family TerB PF05099.8 KOO29779.1 - 0.037 13.7 0.5 9.1 6.0 0.0 2.6 2 1 0 2 2 2 0 Tellurite resistance protein TerB EF-hand_10 PF14788.1 KOO29779.1 - 0.06 13.0 0.7 2 8.1 0.0 2.9 2 1 1 3 3 3 0 EF hand LRR_4 PF12799.2 KOO29780.1 - 2.2e-14 52.6 8.3 7.3e-06 25.4 0.1 4.3 1 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO29780.1 - 2.2e-12 46.5 2.3 1.8e-06 27.5 0.2 3.7 2 1 2 4 4 4 3 Leucine rich repeat Ank_2 PF12796.2 KOO29780.1 - 5.9e-09 36.1 0.0 1.3e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO29780.1 - 2.7e-06 27.4 0.0 7.2e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) LRR_1 PF00560.28 KOO29780.1 - 2.2e-05 23.8 0.7 0.34 11.1 0.0 5.5 7 1 0 7 7 7 1 Leucine Rich Repeat Ank PF00023.25 KOO29780.1 - 3.8e-05 23.2 0.0 0.00022 20.8 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.1 KOO29780.1 - 0.00015 22.1 0.0 0.00045 20.6 0.0 1.9 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO29780.1 - 0.0052 16.9 0.0 0.019 15.1 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeat LRR_7 PF13504.1 KOO29780.1 - 0.0055 16.6 3.4 1.5 9.3 0.0 5.0 6 0 0 6 6 6 1 Leucine rich repeat LRR_6 PF13516.1 KOO29780.1 - 0.11 12.6 0.4 8.6 6.7 0.0 3.8 4 0 0 4 4 4 0 Leucine Rich repeat Carn_acyltransf PF00755.15 KOO29781.1 - 8.9e-45 152.8 0.0 1e-23 83.2 0.0 2.0 1 1 1 2 2 2 2 Choline/Carnitine o-acyltransferase DUF3404 PF11884.3 KOO29781.1 - 0.17 10.7 0.0 0.25 10.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3404) Dynein_heavy PF03028.10 KOO29782.1 - 1.6e-200 667.8 0.0 2.8e-200 666.9 0.0 1.4 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor DHC_N1 PF08385.7 KOO29782.1 - 4.1e-128 428.2 15.4 4.1e-128 428.2 10.7 2.1 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.8 KOO29782.1 - 3.4e-114 381.5 0.0 3.4e-114 381.5 0.0 3.2 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 KOO29782.1 - 6.4e-86 287.6 0.5 2.2e-85 285.8 0.2 2.0 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_8 PF12780.2 KOO29782.1 - 1.1e-70 237.7 0.0 2.7e-70 236.4 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 KOO29782.1 - 3.4e-68 228.8 0.7 9.6e-68 227.4 0.5 1.8 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 MT PF12777.2 KOO29782.1 - 9e-46 156.1 11.2 2.4e-45 154.7 7.8 1.7 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 KOO29782.1 - 2e-44 151.7 0.2 1.6e-43 148.7 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_5 PF07728.9 KOO29782.1 - 4.2e-16 58.9 0.0 0.00016 21.4 0.0 6.1 6 1 0 6 6 6 3 AAA domain (dynein-related subfamily) AAA PF00004.24 KOO29782.1 - 5.6e-07 29.8 0.5 0.059 13.5 0.0 4.6 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO29782.1 - 8.4e-07 29.1 0.1 0.35 10.8 0.0 4.5 3 0 0 3 3 3 2 AAA ATPase domain AAA_33 PF13671.1 KOO29782.1 - 0.0013 18.5 0.2 0.017 15.0 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.1 KOO29782.1 - 0.0014 18.3 6.5 2 8.2 0.1 3.9 3 0 0 3 3 3 2 Part of AAA domain ABC_tran PF00005.22 KOO29782.1 - 0.012 15.9 1.3 3.9 7.7 0.0 3.5 3 0 0 3 3 3 0 ABC transporter AAA_17 PF13207.1 KOO29782.1 - 0.014 16.2 0.1 0.76 10.5 0.0 4.0 3 0 0 3 3 2 0 AAA domain Reo_sigmaC PF04582.7 KOO29782.1 - 0.024 13.8 0.5 1.2 8.2 0.0 2.7 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Mg_chelatase PF01078.16 KOO29782.1 - 0.034 13.3 0.0 0.45 9.6 0.0 2.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 KOO29782.1 - 0.064 13.4 0.0 2.6 8.2 0.0 3.2 2 0 0 2 2 2 0 RNA helicase DUF258 PF03193.11 KOO29782.1 - 0.11 11.6 0.4 0.79 8.8 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 KOO29782.1 - 1.3 9.1 0.0 1.3 9.1 0.0 5.0 6 0 0 6 6 3 0 AAA domain T6SS_Vgr PF13296.1 KOO29783.1 - 0.0007 19.4 1.0 0.0012 18.6 0.7 1.4 1 0 0 1 1 1 1 Putative type VI secretion system Rhs element Vgr EF-hand_7 PF13499.1 KOO29783.1 - 0.014 15.5 0.0 0.038 14.1 0.0 1.8 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.1 KOO29783.1 - 0.024 13.9 0.0 0.059 12.7 0.0 1.7 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.1 KOO29783.1 - 0.057 13.3 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain GAS PF13851.1 KOO29783.1 - 0.1 11.8 1.4 0.12 11.5 0.9 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Rep_fac-A_3 PF08661.6 KOO29784.1 - 4.6e-10 39.3 0.0 5.9e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 Replication factor A protein 3 Ten1_2 PF15490.1 KOO29784.1 - 0.018 14.6 0.0 0.028 13.9 0.0 1.4 1 1 0 1 1 1 0 Telomere-capping, CST complex subunit RVP PF00077.15 KOO29786.1 - 0.18 11.7 0.1 0.39 10.6 0.0 1.5 1 0 0 1 1 1 0 Retroviral aspartyl protease Ribosomal_L5_C PF00673.16 KOO29787.1 - 3.1e-24 84.5 0.0 5.2e-24 83.8 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 KOO29787.1 - 0.023 14.4 0.4 0.079 12.7 0.3 1.9 1 1 0 1 1 1 0 Ribosomal protein L5 MerR_1 PF13411.1 KOO29788.1 - 7.4e-14 51.2 0.0 3.1 7.6 0.0 13.6 15 1 0 15 15 15 1 MerR HTH family regulatory protein DUF2717 PF10911.3 KOO29788.1 - 4.2e-08 32.5 42.5 0.012 15.0 0.1 12.7 4 2 7 13 13 13 3 Protein of unknown function (DUF2717) Pentapeptide_4 PF13599.1 KOO29788.1 - 0.00095 18.9 1.0 21 5.0 0.0 5.2 4 1 2 6 6 6 0 Pentapeptide repeats (9 copies) Ribosomal_L13e PF01294.13 KOO29788.1 - 0.0013 18.2 19.7 7.3 6.0 0.0 11.8 3 3 5 13 13 13 1 Ribosomal protein L13e CBM_3 PF00942.13 KOO29788.1 - 0.016 15.1 14.3 39 4.3 0.0 9.6 6 5 6 12 12 12 0 Cellulose binding domain HTH_27 PF13463.1 KOO29788.1 - 0.047 14.0 0.0 92 3.4 0.0 6.0 7 2 0 7 7 7 0 Winged helix DNA-binding domain AdoMetDC_leader PF08132.6 KOO29788.1 - 0.12 12.2 1.4 9.3 6.2 0.0 4.4 4 0 0 4 4 4 0 S-adenosyl-l-methionine decarboxylase leader peptide DUF3726 PF12525.3 KOO29788.1 - 1.2 8.9 51.6 1.6 8.5 0.9 10.4 8 5 3 11 11 11 0 Protein of unknown function (DUF3726) HAD_2 PF13419.1 KOO29791.1 - 1.7e-21 77.1 0.0 6.8e-21 75.2 0.0 1.8 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOO29791.1 - 6.4e-12 46.3 0.0 8.8e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOO29791.1 - 2.5e-10 39.8 0.0 8e-10 38.2 0.0 1.9 2 0 0 2 2 2 1 HAD-hyrolase-like HAD PF12710.2 KOO29791.1 - 0.0096 16.1 0.0 0.021 14.9 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Herpes_VP19C PF03327.9 KOO29791.1 - 0.036 12.9 0.0 0.054 12.3 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus capsid shell protein VP19C EF-hand_1 PF00036.27 KOO29793.1 - 1.3e-34 114.8 13.5 1.5e-08 33.2 0.0 6.7 6 0 0 6 6 6 5 EF hand EF-hand_7 PF13499.1 KOO29793.1 - 6.1e-31 106.3 9.2 3.2e-14 52.7 0.1 4.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO29793.1 - 3.1e-27 91.9 13.0 4.6e-08 32.2 0.0 6.6 6 0 0 6 6 6 5 EF-hand domain EF-hand_8 PF13833.1 KOO29793.1 - 3.2e-23 81.0 7.7 3.8e-07 29.6 0.2 5.7 4 1 1 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.1 KOO29793.1 - 5.5e-22 76.0 9.9 0.00019 20.6 0.0 6.3 6 0 0 6 6 6 5 EF hand cNMP_binding PF00027.24 KOO29793.1 - 6.4e-20 70.7 0.1 1.1e-19 70.0 0.1 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain EF-hand_9 PF14658.1 KOO29793.1 - 0.0014 18.4 0.0 0.084 12.7 0.0 2.9 3 0 0 3 3 3 1 EF-hand domain EF-hand_4 PF12763.2 KOO29793.1 - 0.0024 17.5 3.6 0.98 9.1 0.0 4.1 3 1 1 4 4 4 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO29793.1 - 0.0032 17.4 0.6 3.3 7.7 0.0 3.5 4 0 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region Toprim_2 PF13155.1 KOO29793.1 - 0.0099 16.1 0.7 2.7 8.3 0.0 3.1 2 1 0 2 2 2 1 Toprim-like DUF853 PF05872.7 KOO29793.1 - 0.086 11.1 0.9 6.4 4.9 0.1 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF853) DUF3954 PF13128.1 KOO29793.1 - 0.14 11.5 0.3 0.36 10.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3954) PNPase PF03726.9 KOO29793.1 - 0.58 10.4 3.0 1.2 9.4 0.2 2.7 3 0 0 3 3 3 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain Fer2 PF00111.22 KOO29794.1 - 8.2e-08 31.8 1.6 1.2e-07 31.3 1.1 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain ShK PF01549.19 KOO29795.1 - 7.1e-15 55.0 34.9 1e-06 28.9 2.8 5.1 5 0 0 5 5 5 3 ShK domain-like 2OG-FeII_Oxy_3 PF13640.1 KOO29795.1 - 2e-11 44.2 0.7 2e-10 41.0 0.1 2.7 3 0 0 3 3 3 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO29795.1 - 3.7e-08 33.5 0.1 1e-07 32.1 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO29795.1 - 1.6e-06 27.6 0.7 5.5e-06 25.9 0.5 1.9 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Mito_fiss_reg PF05308.6 KOO29796.1 - 0.036 13.4 1.0 0.07 12.4 0.7 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator Cortex-I_coil PF09304.5 KOO29796.1 - 0.056 13.5 5.2 0.067 13.2 0.0 3.1 4 0 0 4 4 4 0 Cortexillin I, coiled coil GBP PF02263.14 KOO29797.1 - 1.6e-33 115.8 0.0 1.6e-31 109.2 0.0 2.3 1 1 1 2 2 2 2 Guanylate-binding protein, N-terminal domain RHD3 PF05879.7 KOO29797.1 - 0.00019 19.5 0.0 0.00028 18.9 0.0 1.2 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.18 KOO29797.1 - 0.031 14.2 0.0 0.055 13.4 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF2791 PF10923.3 KOO29797.1 - 0.15 10.6 0.0 0.3 9.6 0.0 1.4 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) AAA_28 PF13521.1 KOO29797.1 - 6.3 6.7 7.5 2.9 7.8 0.1 3.0 3 1 0 3 3 3 0 AAA domain PsbP PF01789.11 KOO29798.1 - 2.1e-25 89.2 0.0 3e-25 88.6 0.0 1.2 1 0 0 1 1 1 1 PsbP Methyltransf_18 PF12847.2 KOO29799.1 - 7.1e-07 29.8 0.2 2e-06 28.3 0.1 1.8 1 1 1 2 2 2 1 Methyltransferase domain DOT1 PF08123.8 KOO29799.1 - 6.2e-05 22.4 0.0 0.00011 21.5 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_31 PF13847.1 KOO29799.1 - 0.0097 15.5 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 KOO29799.1 - 0.013 15.2 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_26 PF13659.1 KOO29799.1 - 0.02 14.8 0.3 0.047 13.7 0.2 1.6 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.14 KOO29799.1 - 0.025 14.1 0.0 0.04 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.9 KOO29799.1 - 0.12 11.7 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain EF-hand_1 PF00036.27 KOO29800.1 - 1.1e-20 71.2 0.3 0.00051 19.1 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO29800.1 - 4.9e-18 63.3 1.1 0.0015 18.2 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO29800.1 - 1.5e-16 60.2 0.8 2.4e-08 34.0 0.0 3.3 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.1 KOO29800.1 - 2e-13 49.7 1.6 3.6e-05 23.2 0.0 4.8 3 2 2 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO29800.1 - 5.8e-09 34.8 4.6 0.19 11.1 0.0 5.0 5 0 0 5 5 5 3 EF hand EF-hand_4 PF12763.2 KOO29800.1 - 0.00056 19.6 0.1 0.83 9.4 0.0 2.8 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand SMC_N PF02463.14 KOO29801.1 - 8.3e-56 188.6 0.0 2.8e-55 186.9 0.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 KOO29801.1 - 1.3e-25 89.7 3.0 1.5e-23 83.0 0.0 3.9 3 1 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.1 KOO29801.1 - 1.5e-14 54.8 0.0 1.5e-14 54.8 0.0 6.9 5 3 1 6 6 6 2 AAA domain AAA_21 PF13304.1 KOO29801.1 - 6.2e-12 46.0 0.0 6.2e-06 26.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.1 KOO29801.1 - 9.6e-07 28.1 6.9 0.01 14.9 0.0 3.4 2 1 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 KOO29801.1 - 5.3e-05 22.6 0.0 0.00012 21.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain EF-hand_5 PF13202.1 KOO29802.1 - 6.9e-16 56.7 0.9 1e-06 27.7 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO29802.1 - 5.2e-14 50.8 0.4 1.1e-06 28.0 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO29802.1 - 2e-12 45.4 4.2 4.1e-06 25.7 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO29802.1 - 6.9e-11 41.5 3.0 7.8e-05 22.2 0.1 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.1 KOO29802.1 - 1.6e-10 40.9 0.1 1.3e-09 38.0 0.0 2.4 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_9 PF14658.1 KOO29802.1 - 0.053 13.4 0.0 13 5.7 0.0 2.6 3 0 0 3 3 3 0 EF-hand domain ABC_tran PF00005.22 KOO29803.1 - 5.9e-34 117.2 0.0 1e-33 116.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 KOO29803.1 - 3.6e-24 85.6 8.5 6.8e-24 84.7 5.9 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.14 KOO29803.1 - 1.1e-07 31.3 0.3 1.7e-05 24.1 0.0 2.5 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 KOO29803.1 - 1.8e-05 24.8 0.0 0.0049 16.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KOO29803.1 - 8.7e-05 22.5 0.0 0.0002 21.4 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 KOO29803.1 - 0.0001 22.4 0.2 0.00092 19.3 0.2 2.3 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO29803.1 - 0.00029 21.6 0.0 0.00099 19.9 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_29 PF13555.1 KOO29803.1 - 0.00069 19.0 0.4 0.0019 17.7 0.3 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF258 PF03193.11 KOO29803.1 - 0.0017 17.5 0.1 0.0044 16.2 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_33 PF13671.1 KOO29803.1 - 0.0066 16.3 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 KOO29803.1 - 0.0067 15.8 1.7 0.23 10.8 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.1 KOO29803.1 - 0.0071 16.6 0.0 0.02 15.2 0.0 1.8 2 0 0 2 2 1 1 AAA domain Mg_chelatase PF01078.16 KOO29803.1 - 0.022 13.8 0.0 0.047 12.8 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI SbcCD_C PF13558.1 KOO29803.1 - 0.024 14.5 2.2 0.077 12.9 0.3 2.8 2 1 0 2 2 1 0 Putative exonuclease SbcCD, C subunit ABC_ATPase PF09818.4 KOO29803.1 - 0.03 12.9 5.6 0.15 10.6 0.2 3.2 4 0 0 4 4 4 0 Predicted ATPase of the ABC class AAA_5 PF07728.9 KOO29803.1 - 0.032 13.9 0.3 0.59 9.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.10 KOO29803.1 - 0.053 13.2 0.2 3.8 7.2 0.0 2.3 2 0 0 2 2 2 0 NTPase MobB PF03205.9 KOO29803.1 - 0.055 13.1 0.0 0.18 11.5 0.0 1.9 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA PF00004.24 KOO29803.1 - 0.067 13.3 5.0 0.8 9.9 1.7 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 KOO29803.1 - 0.071 12.5 0.1 0.36 10.2 0.0 2.1 2 0 0 2 2 2 0 AAA-like domain Exo_endo_phos PF03372.18 KOO29805.1 - 1.6e-16 61.0 0.6 2.3e-16 60.5 0.4 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 KOO29805.1 - 0.0041 16.7 0.2 0.015 14.8 0.1 1.9 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase MORN PF02493.15 KOO29806.1 - 1.2e-38 128.5 43.0 1.1e-05 24.8 0.4 8.7 8 0 0 8 8 8 8 MORN repeat LST1 PF05083.8 KOO29807.1 - 0.18 11.7 0.5 16 5.5 0.0 2.4 2 0 0 2 2 2 0 LST-1 protein DctQ PF04290.7 KOO29807.1 - 0.33 10.7 0.1 0.33 10.7 0.0 2.8 2 1 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component DEAD PF00270.24 KOO29808.1 - 1.7e-42 144.7 0.0 5.8e-42 143.0 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO29808.1 - 1e-21 76.5 0.1 2.3e-21 75.4 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_19 PF13245.1 KOO29808.1 - 0.002 17.8 1.9 0.013 15.2 0.2 2.9 2 0 0 2 2 2 1 Part of AAA domain ResIII PF04851.10 KOO29808.1 - 0.0055 16.5 0.0 0.014 15.1 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.1 KOO29808.1 - 0.019 14.9 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 Helicase C-terminal domain Flavi_DEAD PF07652.9 KOO29808.1 - 0.056 13.1 0.3 0.26 11.0 0.0 2.0 2 0 0 2 2 2 0 Flavivirus DEAD domain UFD1 PF03152.9 KOO29809.1 - 4.7e-12 45.4 0.0 2.3e-10 39.8 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 UIM PF02809.15 KOO29809.1 - 0.017 14.6 0.3 0.017 14.6 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin interaction motif Neur_chan_memb PF02932.11 KOO29810.1 - 8.1e-08 32.4 4.3 8.1e-08 32.4 3.0 1.6 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region OTU PF02338.14 KOO29812.1 - 0.1 13.1 0.0 0.21 12.1 0.0 1.5 1 1 0 1 1 1 0 OTU-like cysteine protease Homeobox PF00046.24 KOO29813.1 - 9.6e-16 57.1 1.7 1.4e-15 56.6 1.2 1.2 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 KOO29813.1 - 0.00026 20.6 0.1 0.00048 19.7 0.1 1.4 1 0 0 1 1 1 1 Homeobox KN domain DNA_mis_repair PF01119.14 KOO29813.1 - 0.032 13.6 0.0 0.045 13.2 0.0 1.2 1 0 0 1 1 1 0 DNA mismatch repair protein, C-terminal domain DUF4079 PF13301.1 KOO29814.1 - 5.5e-12 46.0 11.9 8.3e-10 38.9 8.3 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF4079) Cytochrom_B_N PF00033.14 KOO29814.1 - 0.17 11.2 12.8 0.57 9.5 1.3 2.3 2 1 0 2 2 2 0 Cytochrome b(N-terminal)/b6/petB Ni_hydr_CYTB PF01292.15 KOO29814.1 - 0.21 10.9 11.9 0.5 9.7 0.9 2.2 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 UPF0147 PF03685.8 KOO29816.1 - 0.04 13.7 0.0 0.081 12.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0147) Paramyxo_NS_C PF02725.9 KOO29816.1 - 0.13 11.9 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 Non-structural protein C CAF-1_p150 PF11600.3 KOO29817.1 - 0.5 9.7 18.6 0.6 9.4 12.9 1.0 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal SHOCT PF09851.4 KOO29817.1 - 3.2 7.3 0.0 3.2 7.3 0.0 4.6 5 0 0 5 5 5 0 Short C-terminal domain Ank_2 PF12796.2 KOO29818.1 - 7.3e-18 64.6 6.8 3.6e-10 40.0 0.7 3.0 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO29818.1 - 2e-10 40.5 5.7 2.2e-08 34.0 0.4 3.6 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO29818.1 - 2.1e-08 34.4 2.1 8.4e-08 32.5 0.7 2.7 3 0 0 3 3 2 1 Ankyrin repeats (many copies) Ank PF00023.25 KOO29818.1 - 6e-08 32.1 6.7 1.5e-06 27.7 0.4 3.9 3 1 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.1 KOO29818.1 - 2.3e-05 24.2 1.0 0.0033 17.5 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeat TPR_11 PF13414.1 KOO29818.1 - 2.5e-05 23.8 0.6 2.5e-05 23.8 0.4 2.6 3 0 0 3 3 3 1 TPR repeat TPR_1 PF00515.23 KOO29818.1 - 0.037 13.6 0.3 2.3 7.9 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Lin0512_fam PF09585.5 KOO29818.1 - 0.063 12.8 0.0 0.3 10.6 0.0 2.0 2 0 0 2 2 2 0 Conserved hypothetical protein (Lin0512_fam) TPR_16 PF13432.1 KOO29818.1 - 0.073 13.7 0.9 0.073 13.7 0.6 4.9 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO29818.1 - 0.52 10.3 3.9 1.2 9.2 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 KOO29818.1 - 3.7 7.6 13.2 1.1 9.2 0.1 4.4 5 0 0 5 5 4 0 Tetratricopeptide repeat Big_2 PF02368.13 KOO29820.1 - 0.003 17.4 0.1 0.003 17.4 0.1 3.6 4 0 0 4 4 4 1 Bacterial Ig-like domain (group 2) Cupin_8 PF13621.1 KOO29821.1 - 1.9e-31 109.5 0.1 2.5e-31 109.0 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 KOO29821.1 - 0.00027 20.2 0.3 0.00075 18.8 0.2 1.5 1 1 0 1 1 1 1 Cupin superfamily protein Cupin_2 PF07883.6 KOO29821.1 - 0.0007 19.0 0.2 0.0022 17.4 0.1 1.8 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.17 KOO29821.1 - 0.017 14.5 0.0 0.026 13.9 0.0 1.2 1 0 0 1 1 1 0 Cupin AAA PF00004.24 KOO29822.1 - 0.00022 21.4 0.0 0.00054 20.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 KOO29822.1 - 0.0013 18.6 0.0 0.0032 17.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 KOO29822.1 - 0.0027 17.8 0.0 0.035 14.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain Torsin PF06309.6 KOO29822.1 - 0.0077 16.1 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 Torsin AAA_5 PF07728.9 KOO29822.1 - 0.0084 15.8 0.0 0.21 11.2 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 KOO29822.1 - 0.047 12.7 0.0 0.12 11.3 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus PIF1 PF05970.9 KOO29822.1 - 0.17 10.7 0.0 0.26 10.1 0.0 1.1 1 0 0 1 1 1 0 PIF1-like helicase DUF1049 PF06305.6 KOO29822.1 - 0.23 10.9 2.9 0.78 9.2 2.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Wbp11 PF09429.5 KOO29823.1 - 6.4e-09 35.6 15.4 1e-08 35.0 10.7 1.4 1 0 0 1 1 1 1 WW domain binding protein 11 Phage_GP20 PF06810.6 KOO29823.1 - 0.11 11.9 8.7 0.25 10.7 6.0 1.6 1 1 0 1 1 1 0 Phage minor structural protein GP20 Med28 PF11594.3 KOO29823.1 - 0.15 12.2 2.6 0.31 11.3 1.8 1.5 1 1 0 1 1 1 0 Mediator complex subunit 28 COX16 PF14138.1 KOO29823.1 - 0.84 9.8 6.3 2.5 8.3 0.3 2.3 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 ERM PF00769.14 KOO29823.1 - 0.98 8.9 15.5 1.1 8.6 10.7 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF3347 PF11827.3 KOO29823.1 - 2.2 8.2 5.6 2.7 7.9 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) IncA PF04156.9 KOO29823.1 - 6.5 6.2 10.1 8.4 5.9 7.0 1.2 1 0 0 1 1 1 0 IncA protein RIO1 PF01163.17 KOO29825.1 - 3.5e-46 156.9 0.1 5.6e-46 156.2 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.6 KOO29825.1 - 2.5e-32 110.7 0.1 7.2e-32 109.3 0.0 1.8 2 0 0 2 2 2 1 Rio2, N-terminal APH PF01636.18 KOO29825.1 - 1.4e-10 41.3 3.3 5.4e-05 23.0 0.4 3.0 1 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.9 KOO29825.1 - 2.2e-05 23.6 0.1 0.0028 16.7 0.1 2.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 KOO29825.1 - 0.0026 16.9 0.1 0.0041 16.3 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Med25_VWA PF11265.3 KOO29825.1 - 0.064 12.2 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit 25 von Willebrand factor type A WaaY PF06176.6 KOO29825.1 - 0.1 11.8 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) DUF4341 PF14241.1 KOO29826.1 - 2e-12 46.6 5.5 2e-12 46.6 3.8 4.1 5 1 0 5 5 5 1 Domain of unknown function (DUF4341) Sulf_transp PF04143.9 KOO29826.1 - 7.8e-12 45.0 25.0 1.1e-08 34.8 5.1 6.4 6 1 1 7 7 7 2 Sulphur transport Glyco_transf_28 PF03033.15 KOO29827.1 - 7.3e-07 29.0 0.6 2.3e-06 27.3 0.0 2.2 2 0 0 2 2 2 1 Glycosyltransferase family 28 N-terminal domain Muted PF14942.1 KOO29827.1 - 0.12 12.2 5.5 0.23 11.3 3.8 1.4 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein DSBA PF01323.15 KOO29831.1 - 4.1 6.9 6.7 9.6 5.7 4.6 1.6 1 0 0 1 1 1 0 DSBA-like thioredoxin domain TRP PF06011.7 KOO29834.1 - 0.00055 18.6 5.6 0.0016 17.0 3.9 1.6 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel Ank_2 PF12796.2 KOO29835.1 - 6.1e-07 29.7 0.0 9.6e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO29835.1 - 3e-05 23.8 0.0 0.00018 21.4 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.1 KOO29835.1 - 0.00047 20.5 0.1 0.001 19.5 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.25 KOO29835.1 - 0.0019 17.9 1.7 0.005 16.5 0.2 2.4 3 0 0 3 3 3 1 Ankyrin repeat EF-hand_1 PF00036.27 KOO29836.1 - 0.11 11.8 0.1 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 EF hand PseudoU_synth_1 PF01416.15 KOO29838.1 - 5.4e-19 68.5 0.0 3.8e-08 33.7 0.0 2.6 2 0 0 2 2 2 2 tRNA pseudouridine synthase DHC_N2 PF08393.8 KOO29839.1 - 8.3e-103 344.0 3.4 8.3e-103 344.0 2.4 2.1 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 Kelch_4 PF13418.1 KOO29839.1 - 7e-34 115.3 10.0 6.1e-09 35.5 0.0 7.5 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_3 PF13415.1 KOO29839.1 - 3.2e-29 100.3 19.2 2.5e-08 33.8 0.0 8.7 8 0 0 8 8 8 5 Galactose oxidase, central domain AAA_6 PF12774.2 KOO29839.1 - 4.1e-28 98.4 0.2 7.8e-28 97.5 0.2 1.5 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 Kelch_5 PF13854.1 KOO29839.1 - 4.7e-21 74.3 0.1 0.0048 16.8 0.1 7.6 7 0 0 7 7 7 5 Kelch motif Kelch_1 PF01344.20 KOO29839.1 - 4.1e-15 55.0 6.1 0.0017 17.8 0.4 6.5 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.10 KOO29839.1 - 3e-13 48.9 19.9 0.025 14.3 0.0 8.0 8 0 0 8 8 8 5 Kelch motif Kelch_6 PF13964.1 KOO29839.1 - 3.3e-13 49.1 10.2 0.021 14.9 0.0 8.0 8 1 1 9 9 9 3 Kelch motif Filamin PF00630.14 KOO29839.1 - 1e-11 45.3 0.0 2.1e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 Filamin/ABP280 repeat TIG PF01833.19 KOO29839.1 - 1.9e-08 34.1 0.1 6.6e-08 32.4 0.1 2.0 1 0 0 1 1 1 1 IPT/TIG domain Trypan_PARP PF05887.6 KOO29839.1 - 0.054 13.3 17.1 0.14 11.9 11.9 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) IER PF05760.7 KOO29839.1 - 0.58 10.0 1.9 0.99 9.2 1.3 1.3 1 0 0 1 1 1 0 Immediate early response protein (IER) Mito_carr PF00153.22 KOO29840.1 - 1.3e-31 108.1 1.1 5.3e-17 61.3 0.0 3.2 1 1 1 3 3 3 3 Mitochondrial carrier protein FKBP_C PF00254.23 KOO29841.1 - 1.5e-13 50.5 0.0 2.6e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase AIG1 PF04548.11 KOO29841.1 - 3.3e-07 29.6 0.0 4.9e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 AIG1 family FKBP_N PF01346.13 KOO29841.1 - 0.00011 22.1 0.0 0.00046 20.2 0.0 1.9 2 0 0 2 2 2 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase DUF563 PF04577.9 KOO29842.1 - 3.6e-05 23.7 0.0 5e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Hydrolase_6 PF13344.1 KOO29843.1 - 1.1e-12 47.6 0.0 2.2e-12 46.7 0.0 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOO29843.1 - 1.9e-11 43.5 0.0 5.1e-11 42.1 0.0 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like HAD_2 PF13419.1 KOO29843.1 - 1.5e-06 28.5 0.0 0.0034 17.6 0.0 2.4 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOO29843.1 - 3.6e-05 24.2 0.0 0.14 12.5 0.0 2.5 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO29843.1 - 0.002 18.3 0.0 0.0059 16.7 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.9 KOO29843.1 - 0.082 12.2 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) ADK PF00406.17 KOO29844.1 - 2.1e-54 183.4 0.0 2.5e-54 183.2 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 KOO29844.1 - 1e-10 41.1 0.0 8.6e-09 34.9 0.0 2.5 1 1 0 1 1 1 1 Adenylate kinase, active site lid Zeta_toxin PF06414.7 KOO29844.1 - 1.5e-05 24.2 0.0 2.8e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_17 PF13207.1 KOO29844.1 - 5.9e-05 23.8 0.0 0.00015 22.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 KOO29844.1 - 0.00034 20.5 0.0 0.00063 19.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOO29844.1 - 0.006 16.8 0.0 0.022 15.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 KOO29844.1 - 0.089 12.9 0.1 0.13 12.4 0.1 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SnoaL_2 PF12680.2 KOO29845.1 - 0.043 14.2 0.0 0.056 13.8 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like domain DUF2358 PF10184.4 KOO29845.1 - 0.14 12.1 0.0 0.17 11.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2358) FACT-Spt16_Nlob PF14826.1 KOO29846.1 - 1.7e-44 151.2 0.3 3.9e-44 150.0 0.0 1.8 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain SPT16 PF08644.6 KOO29846.1 - 3.3e-44 150.3 0.1 8.1e-44 149.1 0.0 1.7 1 0 0 1 1 1 1 FACT complex subunit (SPT16/CDC68) Peptidase_M24 PF00557.19 KOO29846.1 - 2.5e-23 82.7 0.0 4.4e-23 81.9 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.7 KOO29846.1 - 3.9e-17 62.0 0.0 8.5e-17 60.9 0.0 1.6 1 0 0 1 1 1 1 Histone chaperone Rttp106-like CDC45 PF02724.9 KOO29846.1 - 0.022 12.8 20.5 0.039 12.0 14.2 1.3 1 0 0 1 1 1 0 CDC45-like protein ADK PF00406.17 KOO29847.1 - 1e-41 142.2 0.0 2.2e-41 141.2 0.0 1.5 1 1 0 1 1 1 1 Adenylate kinase MORN PF02493.15 KOO29847.1 - 3e-13 48.6 37.7 3.4e-08 32.7 1.2 6.2 6 0 0 6 6 6 3 MORN repeat AAA_17 PF13207.1 KOO29847.1 - 6.8e-08 33.3 0.0 1.6e-07 32.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOO29847.1 - 4.8e-07 30.1 0.0 1e-06 29.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 KOO29847.1 - 3.3e-06 27.0 0.0 1.6e-05 24.8 0.0 2.1 2 1 0 2 2 2 1 AAA domain ADK_lid PF05191.9 KOO29847.1 - 0.058 13.0 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 Adenylate kinase, active site lid CK2S PF15011.1 KOO29847.1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Casein Kinase 2 substrate DUF4047 PF13256.1 KOO29848.1 - 0.011 15.6 0.5 0.016 15.1 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) NIF PF03031.13 KOO29849.1 - 3.7e-18 65.7 0.0 6e-18 65.0 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase PTCB-BRCT PF12738.2 KOO29849.1 - 0.00029 20.6 0.1 0.00064 19.5 0.1 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.21 KOO29849.1 - 0.002 18.2 0.0 0.004 17.2 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain VirB3 PF05101.8 KOO29850.1 - 3.1 7.8 12.0 1.2 9.2 0.5 3.2 3 0 0 3 3 3 0 Type IV secretory pathway, VirB3-like protein zf-PARP PF00645.13 KOO29851.1 - 3e-18 65.8 0.1 6e-18 64.8 0.1 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region WGR PF05406.10 KOO29851.1 - 8.6e-11 41.6 0.2 8.6e-11 41.6 0.1 1.8 2 0 0 2 2 2 1 WGR domain PARP PF00644.15 KOO29851.1 - 1.1e-10 41.2 1.7 1.5e-10 40.8 0.0 2.1 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain SAP PF02037.22 KOO29851.1 - 1.1e-08 34.3 2.3 1.6e-08 33.8 0.8 2.0 2 0 0 2 2 2 1 SAP domain BORA_N PF15280.1 KOO29851.1 - 0.016 14.5 0.1 0.032 13.5 0.1 1.4 1 0 0 1 1 1 0 Protein aurora borealis N-terminus Sec7 PF01369.15 KOO29852.1 - 1.8e-45 154.9 0.0 2.7e-45 154.3 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.24 KOO29852.1 - 4.2e-17 62.2 0.0 1.4e-16 60.5 0.0 2.0 2 0 0 2 2 2 1 PH domain PH_11 PF15413.1 KOO29852.1 - 4.5e-11 42.9 0.0 9.1e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain FHA PF00498.21 KOO29852.1 - 7.3e-11 42.0 0.1 2.2e-10 40.4 0.0 1.9 2 0 0 2 2 2 1 FHA domain PH_6 PF15406.1 KOO29852.1 - 0.0013 18.7 0.2 0.9 9.6 0.0 2.5 1 1 1 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.1 KOO29852.1 - 0.1 12.7 0.0 1 9.4 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain PH_3 PF14593.1 KOO29852.1 - 0.1 12.5 0.0 0.25 11.2 0.0 1.7 1 1 0 1 1 1 0 PH domain PH_4 PF15404.1 KOO29852.1 - 0.11 11.9 0.0 2.9 7.3 0.0 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain Ded_cyto PF06920.8 KOO29853.1 - 0.0055 16.0 0.3 0.0055 16.0 0.2 2.0 3 0 0 3 3 3 1 Dedicator of cytokinesis GLE1 PF07817.8 KOO29853.1 - 0.0061 15.5 2.5 0.0061 15.5 1.7 1.6 1 1 0 1 1 1 1 GLE1-like protein DUF1127 PF06568.6 KOO29855.1 - 0.018 14.4 0.1 0.037 13.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1127) HTH_Tnp_ISL3 PF13542.1 KOO29856.1 - 0.064 12.4 0.5 0.068 12.3 0.3 1.1 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 Pkinase PF00069.20 KOO29857.1 - 4.7e-43 147.1 0.0 7.1e-43 146.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO29857.1 - 6.3e-38 130.3 0.0 1.1e-37 129.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO29857.1 - 0.01 14.8 0.0 0.036 13.0 0.0 1.8 2 0 0 2 2 2 0 Kinase-like Shisa PF13908.1 KOO29857.1 - 0.39 10.8 0.0 0.39 10.8 0.0 3.2 4 1 0 4 4 4 0 Wnt and FGF inhibitory regulator CAP-ZIP_m PF15255.1 KOO29858.1 - 2.3 8.1 10.7 2.1 8.2 0.1 3.3 3 0 0 3 3 3 0 WASH complex subunit CAP-Z interacting, central region PP2C PF00481.16 KOO29859.1 - 4.6e-42 144.1 0.0 6.1e-42 143.7 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 KOO29859.1 - 1.8e-06 27.5 0.9 2.6e-05 23.7 0.6 2.1 1 1 0 1 1 1 1 Protein phosphatase 2C CheY-binding PF09078.6 KOO29859.1 - 0.049 13.6 0.1 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 CheY binding Man-6-P_recep PF02157.10 KOO29861.1 - 1.4e-08 34.1 0.0 1.6e-08 33.9 0.0 1.0 1 0 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.5 KOO29861.1 - 0.021 14.0 0.0 0.03 13.5 0.0 1.2 1 0 0 1 1 1 0 Autophagy-related protein 27 COX14 PF14880.1 KOO29861.1 - 0.13 11.9 0.4 0.26 10.9 0.3 1.5 1 0 0 1 1 1 0 Cytochrome oxidase c assembly Guanylate_cyc PF00211.15 KOO29862.1 - 7.8e-17 61.2 0.0 5.6e-08 32.3 0.0 2.4 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AAA_16 PF13191.1 KOO29862.1 - 2e-08 34.4 0.2 0.00023 21.2 0.0 3.7 3 0 0 3 3 3 2 AAA ATPase domain NACHT PF05729.7 KOO29862.1 - 0.041 13.5 0.0 0.091 12.4 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.1 KOO29862.1 - 0.043 13.9 0.0 0.13 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 KOO29862.1 - 0.1 13.0 0.0 0.18 12.2 0.0 1.3 1 0 0 1 1 1 0 Miro-like protein Bac_DnaA PF00308.13 KOO29862.1 - 0.25 10.9 0.0 0.49 9.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein TrwB_AAD_bind PF10412.4 KOO29862.1 - 0.3 9.6 0.0 0.6 8.6 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Arch_ATPase PF01637.13 KOO29862.1 - 0.36 10.4 0.0 0.8 9.3 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase VirB3 PF05101.8 KOO29863.1 - 0.0045 16.9 0.3 67 3.5 0.0 5.8 8 0 0 8 8 8 0 Type IV secretory pathway, VirB3-like protein MIF PF01187.13 KOO29863.1 - 0.14 12.2 14.6 3.1 7.9 0.1 5.0 3 3 1 5 5 5 0 Macrophage migration inhibitory factor (MIF) Phage_Coat_A PF05357.8 KOO29863.1 - 0.57 9.7 8.5 12 5.5 0.1 5.8 8 0 0 8 8 8 0 Phage Coat Protein A TIG PF01833.19 KOO29866.1 - 1.7e-15 56.7 0.0 9.9e-06 25.4 0.0 5.3 5 0 0 5 5 4 3 IPT/TIG domain AAA PF00004.24 KOO29866.1 - 2.8e-14 53.4 0.1 2.5e-06 27.7 0.1 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 KOO29866.1 - 0.00012 21.7 0.7 0.012 15.3 0.1 3.4 2 0 0 2 2 2 1 Part of AAA domain AAA_5 PF07728.9 KOO29866.1 - 0.012 15.3 0.2 3.6 7.2 0.0 2.8 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 KOO29866.1 - 0.032 14.3 0.5 1.3 9.1 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA_28 PF13521.1 KOO29866.1 - 0.034 14.1 1.0 2.1 8.2 0.1 2.7 3 0 0 3 3 3 0 AAA domain Mg_chelatase PF01078.16 KOO29866.1 - 0.037 13.1 0.0 0.3 10.2 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 KOO29866.1 - 0.08 12.8 0.3 0.6 9.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.1 KOO29866.1 - 0.089 12.3 0.6 2.9 7.4 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 KOO29866.1 - 0.11 13.3 0.9 1.5 9.6 0.0 2.6 3 0 0 3 3 2 0 AAA domain RuvB_N PF05496.7 KOO29866.1 - 0.14 11.1 0.0 0.85 8.6 0.0 2.1 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus Torsin PF06309.6 KOO29866.1 - 0.2 11.5 0.0 0.54 10.1 0.0 1.6 1 0 0 1 1 1 0 Torsin AAA_11 PF13086.1 KOO29866.1 - 0.22 11.0 0.0 14 5.1 0.0 2.5 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.1 KOO29866.1 - 0.34 11.2 0.1 0.86 9.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain Mqo PF06039.10 KOO29866.1 - 0.47 8.5 0.0 0.69 8.0 0.0 1.1 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) Thioredoxin PF00085.15 KOO29867.1 - 2.4e-26 91.4 0.1 3.2e-26 91.0 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.1 KOO29867.1 - 5.5e-06 26.3 0.1 9.9e-06 25.5 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_8 PF13905.1 KOO29867.1 - 8.7e-05 22.5 0.0 0.00018 21.5 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 KOO29867.1 - 0.00033 20.8 0.1 0.0029 17.7 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.1 KOO29867.1 - 0.0043 16.6 0.0 0.0066 16.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.16 KOO29867.1 - 0.009 15.6 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 KOO29867.1 - 0.058 12.9 0.0 0.11 12.0 0.0 1.5 2 0 0 2 2 2 0 Redoxin HD_4 PF13328.1 KOO29868.1 - 1.6e-47 161.0 0.2 3.9e-47 159.8 0.2 1.7 1 0 0 1 1 1 1 HD domain RelA_SpoT PF04607.12 KOO29868.1 - 2.7e-28 98.3 0.0 6e-28 97.1 0.0 1.6 1 0 0 1 1 1 1 Region found in RelA / SpoT proteins HD PF01966.17 KOO29868.1 - 4.2e-09 36.4 0.2 1.3e-08 34.8 0.0 2.0 2 0 0 2 2 2 1 HD domain ACT_4 PF13291.1 KOO29868.1 - 1.6e-08 34.7 1.1 2.7e-08 34.0 0.8 1.4 1 0 0 1 1 1 1 ACT domain TGS PF02824.16 KOO29868.1 - 0.00085 19.1 0.0 0.0021 17.8 0.0 1.7 1 0 0 1 1 1 1 TGS domain ACT PF01842.20 KOO29868.1 - 0.00093 18.6 0.2 0.0025 17.2 0.2 1.8 1 0 0 1 1 1 1 ACT domain ThiS PF02597.15 KOO29868.1 - 0.042 14.2 0.0 0.12 12.8 0.0 1.8 1 0 0 1 1 1 0 ThiS family EF-hand_5 PF13202.1 KOO29869.1 - 0.00049 19.3 0.2 0.0014 17.8 0.2 1.8 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KOO29869.1 - 0.0044 16.2 0.1 0.01 15.0 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO29869.1 - 0.013 15.6 0.0 0.03 14.4 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.1 KOO29869.1 - 0.023 14.5 0.1 0.069 13.0 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain DUF1707 PF08044.6 KOO29869.1 - 0.041 13.6 0.0 0.22 11.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1707) Methyltransf_21 PF05050.7 KOO29870.1 - 4.6e-09 36.4 0.0 5.4e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase FkbM domain DUF680 PF05079.7 KOO29870.1 - 0.0034 17.8 0.1 0.006 17.0 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF680) Methyltransf_22 PF13383.1 KOO29870.1 - 0.036 13.5 0.0 0.042 13.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain RNase_P_pop3 PF08228.6 KOO29873.1 - 0.039 13.7 0.3 0.11 12.3 0.1 1.8 2 0 0 2 2 2 0 RNase P subunit Pop3 CM_1 PF07736.6 KOO29875.1 - 0.027 14.5 0.0 0.09 12.8 0.0 1.8 1 0 0 1 1 1 0 Chorismate mutase type I DUF760 PF05542.6 KOO29876.1 - 6e-20 71.2 5.7 3.3e-11 43.1 0.0 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF760) Kelch_4 PF13418.1 KOO29878.1 - 0.00024 20.8 0.0 0.0083 15.8 0.0 2.4 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO29878.1 - 0.031 14.2 0.0 0.23 11.4 0.0 2.1 2 0 0 2 2 2 0 Kelch motif VASP_tetra PF08776.6 KOO29878.1 - 0.032 13.5 3.3 0.068 12.4 2.3 1.5 1 0 0 1 1 1 0 VASP tetramerisation domain Filamin PF00630.14 KOO29879.1 - 4.5e-06 27.1 0.0 0.26 11.8 0.0 3.6 4 0 0 4 4 4 2 Filamin/ABP280 repeat Actin PF00022.14 KOO29880.1 - 2e-70 237.2 0.0 9.2e-62 208.7 0.0 2.0 1 1 1 2 2 2 2 Actin NACHT PF05729.7 KOO29882.1 - 1.3e-05 24.8 0.1 3.6e-05 23.4 0.1 1.8 1 1 0 1 1 1 1 NACHT domain AAA_25 PF13481.1 KOO29882.1 - 3.4e-05 23.3 0.2 6.2e-05 22.4 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOO29882.1 - 0.052 13.2 0.5 0.33 10.7 0.0 2.5 2 0 0 2 2 2 0 Part of AAA domain AAA_16 PF13191.1 KOO29882.1 - 0.088 12.7 5.5 0.17 11.8 0.7 2.9 2 2 0 2 2 2 0 AAA ATPase domain NPDC1 PF06809.6 KOO29884.1 - 0.003 16.4 1.8 0.0034 16.2 1.2 1.1 1 0 0 1 1 1 1 Neural proliferation differentiation control-1 protein (NPDC1) CPSase_L_D2 PF02786.12 KOO29886.1 - 8.1e-54 182.0 0.0 1.2e-53 181.5 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain HMGL-like PF00682.14 KOO29886.1 - 1.3e-30 106.8 0.0 2.7e-30 105.7 0.0 1.6 1 0 0 1 1 1 1 HMGL-like Biotin_carb_C PF02785.14 KOO29886.1 - 1.6e-30 105.2 0.0 3.9e-30 103.9 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain PYC_OADA PF02436.13 KOO29886.1 - 1.3e-17 63.9 0.0 2.1e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain ATP-grasp_4 PF13535.1 KOO29886.1 - 2.7e-07 30.5 0.3 6.2e-07 29.3 0.0 1.7 2 0 0 2 2 2 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 KOO29886.1 - 0.001 18.4 0.0 0.003 16.9 0.0 1.7 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.1 KOO29886.1 - 0.0036 16.1 0.3 0.0082 14.9 0.0 1.7 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon FoP_duplication PF13865.1 KOO29887.1 - 2.7 8.4 7.3 6.4 7.2 5.1 1.6 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 DUF791 PF05631.9 KOO29888.1 - 1.1e-70 238.0 9.9 5.1e-68 229.3 6.9 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF791) MFS_1 PF07690.11 KOO29888.1 - 1.4e-15 56.8 33.1 1.4e-15 56.8 22.9 2.5 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF1601 PF07671.6 KOO29889.1 - 4.5e-20 70.9 39.3 0.004 16.7 0.1 8.8 3 1 6 9 9 9 7 Protein of unknown function (DUF1601) RAP PF08373.5 KOO29889.1 - 1.2e-16 60.2 0.0 1.8e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 RAP domain FAST_1 PF06743.10 KOO29889.1 - 5.2e-06 26.0 0.0 12 5.7 0.0 6.3 2 1 6 8 8 8 2 FAST kinase-like protein, subdomain 1 FAST_2 PF08368.7 KOO29889.1 - 0.0031 17.8 0.0 0.0072 16.6 0.0 1.6 1 1 0 1 1 1 1 FAST kinase-like protein, subdomain 2 DUF427 PF04248.7 KOO29889.1 - 0.14 11.8 22.1 29 4.3 0.1 6.8 7 0 0 7 7 7 0 Domain of unknown function (DUF427) PGA_cap PF09587.5 KOO29889.1 - 0.15 11.3 11.1 0.99 8.7 1.2 2.8 1 1 2 3 3 3 0 Bacterial capsule synthesis protein PGA_cap ShK PF01549.19 KOO29890.1 - 8.2e-09 35.6 23.9 2.6e-07 30.8 2.3 3.9 4 0 0 4 4 4 3 ShK domain-like YlqD PF11068.3 KOO29892.1 - 0.077 13.0 0.1 0.14 12.2 0.1 1.4 1 0 0 1 1 1 0 YlqD protein SPX PF03105.14 KOO29892.1 - 0.2 11.4 0.2 0.27 10.9 0.1 1.1 1 0 0 1 1 1 0 SPX domain LRR_6 PF13516.1 KOO29893.1 - 1.8e-52 169.4 14.1 0.00012 21.8 0.0 11.6 11 0 0 11 11 11 10 Leucine Rich repeat LRR_1 PF00560.28 KOO29893.1 - 1.3e-12 45.8 0.0 13 6.2 0.0 10.0 11 0 0 11 11 11 1 Leucine Rich Repeat LRR_8 PF13855.1 KOO29893.1 - 1.3e-08 34.4 10.4 0.098 12.4 0.2 6.7 3 2 4 7 7 7 5 Leucine rich repeat LRR_4 PF12799.2 KOO29893.1 - 1.9e-07 30.5 20.1 0.36 10.5 0.2 7.5 2 2 8 10 10 10 6 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO29893.1 - 4.4e-07 29.0 12.7 45 4.8 0.0 9.8 10 0 0 10 10 10 0 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO29893.1 - 0.00085 19.4 13.8 0.041 14.0 0.2 5.8 3 3 3 6 6 6 1 RNA 2'-O ribose methyltransferase substrate binding YycC PF14174.1 KOO29893.1 - 0.0014 18.2 0.0 1.8e+02 1.8 0.0 6.7 8 0 0 8 8 8 0 YycC-like protein Rhabdo_glycop PF00974.13 KOO29893.1 - 0.3 9.2 0.0 0.46 8.6 0.0 1.2 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein DUF2202 PF09968.4 KOO29893.1 - 0.56 9.8 6.5 24 4.5 0.2 4.4 1 1 2 4 4 4 0 Uncharacterized protein domain (DUF2202) CbiG_N PF11760.3 KOO29893.1 - 4.8 6.9 25.9 67 3.2 0.0 8.3 5 3 3 9 9 9 0 Cobalamin synthesis G N-terminal SbcCD_C PF13558.1 KOO29894.1 - 0.02 14.7 0.1 0.046 13.6 0.1 1.7 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit V-SNARE PF05008.10 KOO29895.1 - 0.025 14.7 0.1 26 5.0 0.0 3.0 1 1 2 3 3 3 0 Vesicle transport v-SNARE protein N-terminus DUF1205 PF06722.7 KOO29895.1 - 0.17 12.1 2.3 7 6.9 0.1 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1205) DUF2765 PF10963.3 KOO29895.1 - 4.7 7.2 5.6 46 4.0 0.3 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF2765) Hc1 PF07432.8 KOO29895.1 - 5.7 7.1 19.2 6.2 7.0 6.2 2.0 1 1 1 2 2 2 0 Histone H1-like protein Hc1 LRR_6 PF13516.1 KOO29896.1 - 2.7e-15 54.6 4.9 0.0026 17.6 0.0 6.4 6 0 0 6 6 6 5 Leucine Rich repeat LRR_4 PF12799.2 KOO29896.1 - 8.9e-10 37.9 0.1 0.0011 18.5 0.0 3.8 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO29896.1 - 0.0002 21.0 1.1 0.65 9.8 0.3 4.3 4 1 0 4 4 4 2 Leucine rich repeat LRR_1 PF00560.28 KOO29896.1 - 0.0023 17.6 0.9 28 5.2 0.1 5.0 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_7 PF13504.1 KOO29896.1 - 0.0062 16.5 2.9 11 6.7 0.0 5.4 5 1 1 6 6 6 1 Leucine rich repeat AAA_5 PF07728.9 KOO29897.1 - 4.8e-39 133.2 0.0 4.1e-15 55.7 0.0 5.8 6 0 0 6 6 6 4 AAA domain (dynein-related subfamily) AAA PF00004.24 KOO29897.1 - 3.6e-09 36.9 0.1 1.2e-05 25.5 0.0 4.1 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO29897.1 - 8.8e-09 35.6 4.4 3.2e-05 24.0 0.0 4.3 4 0 0 4 4 4 2 AAA ATPase domain AAA_22 PF13401.1 KOO29897.1 - 1.5e-08 34.8 0.0 0.048 13.8 0.0 4.6 4 0 0 4 4 4 2 AAA domain AAA_3 PF07726.6 KOO29897.1 - 9.3e-08 31.7 0.0 0.00057 19.4 0.0 3.3 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 KOO29897.1 - 0.00013 21.8 0.0 3.6 7.4 0.0 3.8 3 0 0 3 3 3 2 AAA domain Mg_chelatase PF01078.16 KOO29897.1 - 0.0011 18.1 0.0 0.17 11.0 0.0 3.2 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_17 PF13207.1 KOO29897.1 - 0.0037 18.0 0.0 3.3 8.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain UPF0079 PF02367.12 KOO29897.1 - 0.015 14.9 0.0 3.1 7.4 0.0 3.1 3 0 0 3 3 3 0 Uncharacterised P-loop hydrolase UPF0079 TIP49 PF06068.8 KOO29897.1 - 0.033 12.9 0.1 1.7 7.2 0.0 3.2 4 0 0 4 4 4 0 TIP49 C-terminus AAA_18 PF13238.1 KOO29897.1 - 0.27 11.5 0.0 16 5.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 KOO29897.1 - 0.29 11.0 0.0 42 4.0 0.0 2.9 2 0 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 KOO29897.1 - 1 9.0 0.0 46 3.6 0.0 2.4 3 0 0 3 3 2 0 Archaeal ATPase Rad17 PF03215.10 KOO29897.1 - 2.3 6.7 0.0 10 4.6 0.0 1.8 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein OmpA PF00691.15 KOO29898.1 - 5.8e-07 29.8 0.0 1e-06 29.0 0.0 1.3 1 0 0 1 1 1 1 OmpA family Peptidase_S10 PF00450.17 KOO29899.1 - 3.1e-48 164.9 0.0 1.3e-47 162.8 0.0 1.9 1 1 0 1 1 1 1 Serine carboxypeptidase DNA_pol_B_palm PF14792.1 KOO29899.1 - 5.8e-10 39.2 0.0 1.6e-09 37.7 0.0 1.8 1 1 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.1 KOO29899.1 - 3.3e-07 29.8 0.0 7.3e-07 28.7 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.4 KOO29899.1 - 3.8e-05 23.1 0.0 0.0014 18.1 0.0 2.4 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda HHH_5 PF14520.1 KOO29899.1 - 0.0063 16.6 0.0 0.7 10.1 0.0 3.0 3 0 0 3 3 3 1 Helix-hairpin-helix domain HHH PF00633.18 KOO29899.1 - 0.0079 15.8 0.0 8.3 6.3 0.0 3.1 2 0 0 2 2 2 2 Helix-hairpin-helix motif NTP_transf_2 PF01909.18 KOO29899.1 - 0.0086 16.3 0.0 0.02 15.1 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain HHH_8 PF14716.1 KOO29899.1 - 0.066 13.3 0.0 2.4 8.4 0.0 2.5 2 0 0 2 2 2 0 Helix-hairpin-helix domain HHH_3 PF12836.2 KOO29899.1 - 0.25 11.3 0.0 7 6.6 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix motif EF-hand_1 PF00036.27 KOO29901.1 - 2.8e-13 48.0 0.3 2.5e-05 23.2 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO29901.1 - 3.1e-10 40.0 0.0 1.3e-09 38.0 0.0 2.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO29901.1 - 9.9e-10 37.8 7.0 1.2e-06 28.0 0.5 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO29901.1 - 3e-09 35.7 0.1 0.0022 17.2 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO29901.1 - 2e-08 33.4 0.4 0.0081 15.9 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_9 PF14658.1 KOO29901.1 - 1.6e-05 24.6 0.1 3.5e-05 23.6 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.2 KOO29901.1 - 0.012 15.3 0.2 0.043 13.5 0.1 2.0 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand DUF2422 PF10337.4 KOO29901.1 - 0.55 8.9 15.6 0.78 8.4 10.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2422) LANC_like PF05147.8 KOO29902.1 - 8.4e-37 126.5 0.0 1e-36 126.2 0.0 1.0 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein Prenyltrans_1 PF13243.1 KOO29902.1 - 0.015 15.3 1.1 0.037 14.0 0.1 2.1 2 0 0 2 2 2 0 Prenyltransferase-like SHIPPO-rpt PF07004.7 KOO29903.1 - 0.00025 21.7 2.3 0.0026 18.5 0.4 6.9 7 0 0 7 7 7 4 Sperm-tail PG-rich repeat PEP_mutase PF13714.1 KOO29904.1 - 3.7e-43 147.4 1.4 4.3e-43 147.2 1.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.16 KOO29904.1 - 9.8e-12 43.8 1.3 1.2e-11 43.5 0.9 1.1 1 0 0 1 1 1 1 Isocitrate lyase family zinc_ribbon_6 PF14599.1 KOO29906.1 - 4.9e-27 93.4 0.2 4.9e-27 93.4 0.1 4.1 3 1 1 4 4 4 1 Zinc-ribbon zf-CHY PF05495.7 KOO29906.1 - 8.1e-13 48.3 18.7 8.1e-13 48.3 13.0 4.8 3 1 0 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.1 KOO29906.1 - 1.1e-10 41.1 5.1 1.1e-10 41.1 3.5 4.7 3 1 2 5 5 5 1 Ring finger domain zf-RING_UBOX PF13445.1 KOO29906.1 - 1.8e-08 33.9 0.1 1.8e-08 33.9 0.0 3.2 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.20 KOO29906.1 - 1.4e-07 31.0 2.3 1.4e-07 31.0 1.6 4.6 4 2 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO29906.1 - 1.5e-07 31.3 4.4 1.5e-07 31.3 3.1 5.4 4 2 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO29906.1 - 9.6e-07 28.4 4.0 9.6e-07 28.4 2.8 5.9 3 3 2 5 5 5 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 KOO29906.1 - 5.8e-06 26.0 4.4 5.8e-06 26.0 3.0 4.9 5 2 1 6 6 6 1 zinc finger of C3HC4-type, RING HypA PF01155.14 KOO29906.1 - 0.026 14.1 0.9 0.026 14.1 0.6 4.7 1 1 3 4 4 4 0 Hydrogenase expression/synthesis hypA family SPRY PF00622.23 KOO29907.1 - 2.4e-17 63.1 0.6 1.1e-11 44.8 0.0 2.5 2 0 0 2 2 2 2 SPRY domain PHD PF00628.24 KOO29907.1 - 0.036 13.7 0.3 0.076 12.7 0.2 1.5 1 0 0 1 1 1 0 PHD-finger Ank_2 PF12796.2 KOO29908.1 - 6e-28 97.0 0.7 4.1e-19 68.7 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO29908.1 - 4.9e-19 67.9 0.7 3.4e-09 36.6 0.0 3.1 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO29908.1 - 2.3e-18 64.9 0.0 1.9e-06 27.4 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.1 KOO29908.1 - 1.4e-16 60.4 0.0 4.3e-06 27.1 0.0 2.8 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO29908.1 - 1e-11 43.8 0.1 0.0012 18.8 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeat HEAT_PBS PF03130.11 KOO29908.1 - 0.037 14.4 1.1 49 4.8 0.1 4.0 4 1 0 4 4 4 0 PBS lyase HEAT-like repeat LMF1 PF06762.9 KOO29910.1 - 4.6e-11 42.1 0.0 1.9e-09 36.7 0.0 2.1 2 0 0 2 2 2 2 Lipase maturation factor ShK PF01549.19 KOO29910.1 - 0.03 14.6 0.9 0.051 13.9 0.7 1.4 1 0 0 1 1 1 0 ShK domain-like MitoNEET_N PF10660.4 KOO29911.1 - 0.15 11.8 0.1 0.15 11.8 0.1 2.6 3 0 0 3 3 3 0 Iron-containing outer mitochondrial membrane protein N-terminus PKD_channel PF08016.7 KOO29912.1 - 9.2e-08 30.9 0.0 1.5e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Polycystin cation channel DUF3053 PF11254.3 KOO29912.1 - 0.0099 15.1 0.4 0.017 14.3 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3053) DUF106 PF01956.11 KOO29912.1 - 0.31 10.5 3.4 1.3 8.5 0.1 2.2 2 0 0 2 2 2 0 Integral membrane protein DUF106 CemA PF03040.9 KOO29912.1 - 0.92 9.0 4.2 0.26 10.8 0.1 1.9 2 0 0 2 2 2 0 CemA family TMPIT PF07851.8 KOO29912.1 - 4.2 6.3 7.4 0.81 8.6 2.0 1.9 2 0 0 2 2 2 0 TMPIT-like protein Med4 PF10018.4 KOO29912.1 - 6.4 6.1 11.5 0.079 12.3 2.7 1.6 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 UMP1 PF05348.6 KOO29913.1 - 6e-26 90.9 0.0 7.2e-26 90.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 ANT PF03374.9 KOO29913.1 - 0.14 12.1 0.0 0.22 11.5 0.0 1.3 1 1 0 1 1 1 0 Phage antirepressor protein KilAC domain DUF2248 PF10005.4 KOO29915.1 - 0.012 14.5 0.1 0.017 14.0 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2248) L27_N PF09060.5 KOO29915.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 L27_N Ion_trans PF00520.26 KOO29917.1 - 1.1e-163 540.5 60.7 2e-47 161.0 2.0 4.4 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 KOO29917.1 - 0.00014 20.4 1.9 0.00014 20.4 1.3 8.7 6 3 3 9 9 9 6 Polycystin cation channel Sec7 PF01369.15 KOO29918.1 - 6.1e-66 221.7 0.1 1.9e-65 220.1 0.0 1.9 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.2 KOO29918.1 - 2.8e-45 153.7 12.0 3e-45 153.6 4.1 3.0 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.5 KOO29918.1 - 9.1e-26 89.2 3.2 1.4e-23 82.2 0.0 4.5 5 0 0 5 5 5 2 Domain of unknown function (DUF1981) Ank_2 PF12796.2 KOO29919.1 - 6.9e-19 67.9 0.2 1.3e-18 67.0 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO29919.1 - 8.4e-19 66.3 0.7 6.3e-09 35.2 0.1 2.4 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 KOO29919.1 - 1.2e-17 63.8 1.3 4.7e-13 49.2 0.3 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO29919.1 - 5.1e-17 61.5 0.3 3.5e-10 39.7 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO29919.1 - 8.8e-15 53.3 0.2 3.2e-07 29.9 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Enkurin PF13864.1 KOO29919.1 - 7 6.9 11.4 0.39 10.9 2.5 2.3 2 0 0 2 2 2 0 Calmodulin-binding 2OG-FeII_Oxy_3 PF13640.1 KOO29920.1 - 3.7e-13 49.8 0.0 8.1e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SAM_2 PF07647.12 KOO29920.1 - 3.9e-11 42.6 0.0 6.5e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 KOO29920.1 - 7.6e-08 32.4 0.0 1.3e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) 2OG-FeII_Oxy PF03171.15 KOO29920.1 - 0.035 14.3 0.0 0.12 12.7 0.0 1.9 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily PDEase_I PF00233.14 KOO29921.1 - 8.7e-24 84.5 0.0 9e-22 77.9 0.0 2.1 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase WD40 PF00400.27 KOO29922.1 - 1.6e-06 27.7 4.1 0.047 13.6 0.0 3.8 5 0 0 5 5 5 2 WD domain, G-beta repeat CPSF_A PF03178.10 KOO29922.1 - 0.00081 18.5 0.0 1.2 8.1 0.0 2.3 3 0 0 3 3 3 2 CPSF A subunit region Kelch_3 PF13415.1 KOO29923.1 - 1.8e-45 152.1 19.9 4e-11 42.7 0.1 7.3 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_4 PF13418.1 KOO29923.1 - 5.3e-40 134.9 24.8 4.5e-09 35.9 0.0 7.2 6 1 1 7 7 7 6 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO29923.1 - 1.3e-32 111.1 0.4 1e-05 25.3 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.1 KOO29923.1 - 1.3e-29 101.0 4.4 8.2e-06 25.7 0.0 6.3 5 1 1 6 6 6 5 Kelch motif Kelch_1 PF01344.20 KOO29923.1 - 1.6e-29 101.2 0.0 1.3e-07 30.9 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.10 KOO29923.1 - 2.4e-26 90.4 4.9 0.00017 21.2 0.0 6.8 6 1 0 6 6 6 5 Kelch motif DUF2576 PF10845.3 KOO29923.1 - 0.12 11.5 0.0 0.34 10.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2576) Ax_dynein_light PF10211.4 KOO29923.1 - 0.15 11.8 1.3 11 5.8 0.0 2.6 3 0 0 3 3 3 0 Axonemal dynein light chain zf-RING_2 PF13639.1 KOO29924.1 - 2.8e-14 52.6 2.5 2.8e-14 52.6 1.8 1.8 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.2 KOO29924.1 - 4.6e-10 39.4 0.1 1.1e-09 38.2 0.1 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 KOO29924.1 - 9.7e-09 35.1 2.0 2.3e-08 33.9 1.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO29924.1 - 4.6e-07 29.3 0.6 9.9e-07 28.3 0.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO29924.1 - 5.3e-07 29.2 1.2 5.3e-07 29.2 0.8 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO29924.1 - 9.5e-07 28.4 1.0 9.5e-07 28.4 0.7 1.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-Apc11 PF12861.2 KOO29924.1 - 7.7e-06 25.6 0.7 1.5e-05 24.7 0.5 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 KOO29924.1 - 0.0017 17.8 2.2 0.0033 16.9 1.5 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.1 KOO29924.1 - 0.01 15.6 1.7 0.041 13.7 1.2 2.1 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 KOO29924.1 - 0.027 14.2 2.9 1 9.1 0.1 2.4 2 0 0 2 2 2 0 RING-type zinc-finger FANCL_C PF11793.3 KOO29924.1 - 0.049 13.5 5.0 0.62 10.0 3.4 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.2 KOO29924.1 - 0.15 12.1 2.3 0.52 10.4 1.6 1.9 1 1 0 1 1 1 0 RING-variant domain Retinal PF15449.1 KOO29924.1 - 0.72 7.4 7.1 0.89 7.1 4.9 1.2 1 0 0 1 1 1 0 Retinal protein DUF1620 PF07774.8 KOO29925.1 - 3.4e-52 176.8 0.0 4.7e-52 176.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1620) PQQ_2 PF13360.1 KOO29925.1 - 1.6e-06 27.7 3.5 6.1e-06 25.8 2.3 1.9 1 1 0 1 1 1 1 PQQ-like domain NACHT PF05729.7 KOO29925.1 - 0.00021 20.9 0.0 0.00041 20.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain PQQ PF01011.16 KOO29925.1 - 0.032 13.7 0.0 6.8 6.4 0.0 3.2 2 0 0 2 2 2 0 PQQ enzyme repeat Zeta_toxin PF06414.7 KOO29925.1 - 0.22 10.5 0.0 0.43 9.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin RRM_1 PF00076.17 KOO29925.1 - 0.42 10.2 0.0 1 9.0 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CheZ PF04344.8 KOO29925.1 - 2.2 7.8 3.4 1.7 8.2 0.2 2.2 2 0 0 2 2 2 0 Chemotaxis phosphatase, CheZ Glyco_hydro_2_C PF02836.12 KOO29926.1 - 3.3e-77 259.3 0.0 1.2e-76 257.5 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.13 KOO29926.1 - 1.1e-44 152.0 0.0 1.7e-44 151.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.16 KOO29926.1 - 8.6e-08 32.6 0.0 2.1e-07 31.3 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 2 Bgal_small_N PF02929.12 KOO29926.1 - 0.0068 15.4 0.0 0.01 14.8 0.0 1.2 1 0 0 1 1 1 1 Beta galactosidase small chain Glyco_hydro_72 PF03198.9 KOO29926.1 - 0.025 13.5 0.0 0.039 12.9 0.0 1.2 1 0 0 1 1 1 0 Glucanosyltransferase Glyco_hydro_42 PF02449.10 KOO29926.1 - 0.11 11.5 0.0 0.31 10.0 0.0 1.6 2 0 0 2 2 2 0 Beta-galactosidase VCBS PF13517.1 KOO29928.1 - 1.3e-127 416.2 140.4 6.2e-14 52.0 3.8 13.1 1 1 12 13 13 13 13 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO29928.1 - 6e-75 245.4 135.7 4.2e-06 26.2 0.8 14.4 14 0 0 14 14 14 14 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO29928.1 - 3.6e-23 81.9 63.3 0.21 10.9 0.1 14.0 2 2 11 14 14 14 14 Insecticide toxin TcdB middle/N-terminal region Phage_AlpA PF05930.7 KOO29928.1 - 3.1e-05 23.6 0.0 82 3.0 0.0 7.9 10 0 0 10 10 10 0 Prophage CP4-57 regulatory protein (AlpA) NUDIX PF00293.23 KOO29928.1 - 0.00015 21.3 0.0 21 4.7 0.0 7.0 9 2 0 9 9 9 0 NUDIX domain Arrestin_N PF00339.24 KOO29928.1 - 0.00098 18.9 0.0 1.3e+02 2.3 0.0 7.6 12 0 0 12 12 12 0 Arrestin (or S-antigen), N-terminal domain DUF1117 PF06547.7 KOO29928.1 - 0.014 15.4 0.1 1.6e+02 2.3 0.0 6.4 11 0 0 11 11 11 0 Protein of unknown function (DUF1117) EF-hand_5 PF13202.1 KOO29928.1 - 0.081 12.2 97.5 3.4 7.1 0.3 14.6 14 0 0 14 14 14 0 EF hand DAP_B PF07930.7 KOO29928.1 - 0.27 10.9 1.5 59 3.4 0.0 4.8 5 1 1 6 6 6 0 D-aminopeptidase, domain B Lantibiotic_a PF14867.1 KOO29928.1 - 0.45 9.8 1.4 13 5.1 0.1 3.6 2 0 0 2 2 2 0 Lantibiotic alpha EF-hand_1 PF00036.27 KOO29928.1 - 0.66 9.4 66.3 24 4.5 0.1 14.1 14 0 0 14 14 14 0 EF hand Lipase_bact_N PF12262.3 KOO29928.1 - 4.2 6.5 12.8 47 3.0 0.0 6.1 6 0 0 6 6 6 0 Bacterial virulence factor lipase N-terminal LRR_4 PF12799.2 KOO29929.1 - 2.2e-23 81.4 3.6 6.3e-06 25.6 0.5 5.7 3 2 3 6 6 6 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO29929.1 - 2.9e-18 65.3 5.8 1.3e-09 37.6 0.3 4.5 3 1 1 4 4 4 4 Leucine rich repeat LRR_1 PF00560.28 KOO29929.1 - 1.2e-11 42.9 11.5 0.15 12.2 0.0 8.7 7 1 1 8 8 8 3 Leucine Rich Repeat LRR_6 PF13516.1 KOO29929.1 - 2.2e-10 39.5 9.4 0.028 14.4 0.0 7.9 5 3 3 8 8 8 3 Leucine Rich repeat LRR_7 PF13504.1 KOO29929.1 - 1.6e-07 30.3 15.6 0.12 12.6 0.1 7.4 8 0 0 8 8 8 3 Leucine rich repeat WD40 PF00400.27 KOO29930.1 - 4.2e-36 121.5 8.3 8.4e-09 34.9 0.0 6.8 7 1 0 7 7 7 6 WD domain, G-beta repeat EF-hand_6 PF13405.1 KOO29933.1 - 6.6e-54 174.9 26.5 0.0002 20.9 0.1 16.5 16 1 1 17 17 17 14 EF-hand domain EF-hand_7 PF13499.1 KOO29933.1 - 1.9e-49 165.6 38.3 6.5e-08 32.5 0.4 14.5 12 3 1 14 14 14 11 EF-hand domain pair EF-hand_1 PF00036.27 KOO29933.1 - 2.1e-49 161.1 29.5 2.2e-05 23.4 0.1 16.4 16 1 0 16 16 16 14 EF hand EF-hand_8 PF13833.1 KOO29933.1 - 8.2e-27 92.5 45.2 0.0033 16.9 0.1 15.1 11 5 5 16 16 16 10 EF-hand domain pair EF-hand_5 PF13202.1 KOO29933.1 - 2.1e-17 61.5 34.4 0.014 14.7 0.0 12.6 13 0 0 13 13 13 6 EF hand DUF960 PF06124.6 KOO29933.1 - 0.0077 16.4 2.4 44 4.4 0.0 5.3 8 0 0 8 8 8 0 Staphylococcal protein of unknown function (DUF960) EF-hand_10 PF14788.1 KOO29933.1 - 0.02 14.5 22.4 16 5.2 0.0 10.0 10 1 1 11 11 11 0 EF hand SAP PF02037.22 KOO29933.1 - 0.033 13.7 0.2 12 5.5 0.1 3.6 3 0 0 3 3 3 0 SAP domain EF-hand_4 PF12763.2 KOO29933.1 - 0.45 10.2 30.9 2.4 7.9 0.0 9.6 9 2 2 11 11 11 0 Cytoskeletal-regulatory complex EF hand ThiF PF00899.16 KOO29934.1 - 6.9e-44 148.9 0.3 1.2e-43 148.1 0.1 1.5 2 0 0 2 2 2 1 ThiF family MoeZ_MoeB PF05237.8 KOO29934.1 - 6.6e-24 83.3 0.0 1.3e-23 82.3 0.0 1.5 1 0 0 1 1 1 1 MoeZ/MoeB domain Rhodanese PF00581.15 KOO29934.1 - 1.1e-06 28.9 0.0 4.3e-06 27.0 0.0 2.0 3 0 0 3 3 3 1 Rhodanese-like domain RVT_2 PF07727.9 KOO29935.1 - 1e-33 116.3 0.0 1.7e-33 115.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KOO29935.1 - 4e-06 26.9 0.0 2.6e-05 24.2 0.0 2.2 2 0 0 2 2 2 1 Integrase core domain C1_3 PF07649.7 KOO29935.1 - 1.1 9.2 12.3 3.5 7.7 8.5 1.9 1 1 0 1 1 1 0 C1-like domain DUF1336 PF07059.7 KOO29937.1 - 4.9e-25 88.2 0.0 6.8e-25 87.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1336) PH PF00169.24 KOO29937.1 - 0.00063 19.9 0.0 0.85 9.8 0.0 2.6 2 0 0 2 2 2 2 PH domain SNF2_N PF00176.18 KOO29940.1 - 6.3e-57 192.6 0.0 9.7e-57 192.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-RING_2 PF13639.1 KOO29940.1 - 8.1e-09 35.1 5.8 1.9e-08 33.9 4.0 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 KOO29940.1 - 4.3e-06 26.6 6.2 8.6e-06 25.6 4.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO29940.1 - 1.4e-05 24.6 5.0 3e-05 23.5 3.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO29940.1 - 0.00013 21.5 3.6 0.00031 20.3 2.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO29940.1 - 0.00023 20.8 4.4 0.00047 19.8 3.1 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Tmpp129 PF10272.4 KOO29940.1 - 0.0031 16.3 2.6 0.0054 15.4 1.8 1.3 1 0 0 1 1 1 1 Putative transmembrane protein precursor zf-RING_UBOX PF13445.1 KOO29940.1 - 0.0056 16.3 0.1 0.016 14.9 0.0 1.8 1 0 0 1 1 1 1 RING-type zinc-finger Helicase_C PF00271.26 KOO29940.1 - 0.019 14.8 0.0 0.047 13.5 0.0 1.7 1 0 0 1 1 1 0 Helicase conserved C-terminal domain RRM_6 PF14259.1 KOO29940.1 - 0.044 13.7 0.0 0.59 10.1 0.0 2.8 1 1 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-RING_4 PF14570.1 KOO29940.1 - 0.43 10.2 4.5 0.96 9.0 3.1 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Apc11 PF12861.2 KOO29940.1 - 0.54 10.1 4.6 2.6 7.9 3.2 2.1 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Baculo_RING PF05883.6 KOO29940.1 - 0.65 9.8 0.1 1.4 8.8 0.1 1.4 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain FANCL_C PF11793.3 KOO29940.1 - 1.1 9.2 3.1 2.3 8.2 1.6 1.9 2 0 0 2 2 2 0 FANCL C-terminal domain DUF3138 PF11336.3 KOO29940.1 - 1.2 7.1 4.6 3 5.9 3.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Filamin PF00630.14 KOO29941.1 - 6.8e-41 138.9 0.0 2.3e-11 44.1 0.0 6.2 6 0 0 6 6 6 5 Filamin/ABP280 repeat EF-hand_1 PF00036.27 KOO29941.1 - 1.1e-07 30.5 0.5 3.4e-07 29.0 0.1 2.0 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO29941.1 - 8.5e-07 29.0 0.2 1.9e-06 27.9 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO29941.1 - 4.6e-06 25.7 0.7 1.4e-05 24.2 0.5 1.9 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO29941.1 - 6.2e-06 25.6 1.2 1.4e-05 24.6 0.2 2.0 2 0 0 2 2 2 1 EF-hand domain Big_3_4 PF13754.1 KOO29941.1 - 0.018 15.3 0.2 6.5 7.1 0.0 3.5 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 3) EF-hand_8 PF13833.1 KOO29941.1 - 0.031 13.8 0.5 0.091 12.3 0.2 1.9 1 1 1 2 2 2 0 EF-hand domain pair Vfa1 PF08432.5 KOO29942.1 - 0.054 13.5 10.0 0.055 13.4 6.9 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF1510 PF07423.6 KOO29942.1 - 0.24 10.7 14.3 0.23 10.8 9.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) CobT PF06213.7 KOO29942.1 - 0.25 10.4 24.1 0.25 10.4 16.7 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RNA_pol_Rpc4 PF05132.9 KOO29942.1 - 0.7 9.8 4.0 0.8 9.6 2.8 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 Spore_coat_CotO PF14153.1 KOO29942.1 - 0.99 8.8 7.6 1 8.7 5.3 1.1 1 0 0 1 1 1 0 Spore coat protein CotO NOA36 PF06524.7 KOO29942.1 - 1.1 8.4 18.2 1.2 8.3 12.6 1.2 1 0 0 1 1 1 0 NOA36 protein eIF-3c_N PF05470.7 KOO29942.1 - 1.2 7.1 10.0 1.2 7.1 6.9 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus CDC45 PF02724.9 KOO29942.1 - 1.4 6.8 19.2 1.3 6.9 13.3 1.0 1 0 0 1 1 1 0 CDC45-like protein YqfQ PF14181.1 KOO29942.1 - 1.7 8.6 4.2 1.8 8.5 2.9 1.1 1 0 0 1 1 1 0 YqfQ-like protein TLP-20 PF06088.6 KOO29942.1 - 3.1 7.4 7.1 3.6 7.2 4.9 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) CENP-T PF15511.1 KOO29942.1 - 4.3 6.4 15.5 4.3 6.4 10.7 1.0 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Paf1 PF03985.8 KOO29942.1 - 4.5 5.8 18.8 4.4 5.9 13.0 1.0 1 0 0 1 1 1 0 Paf1 Sporozoite_P67 PF05642.6 KOO29942.1 - 4.9 4.8 13.6 6 4.6 9.5 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2457 PF10446.4 KOO29942.1 - 4.9 5.7 35.4 5.4 5.6 24.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Daxx PF03344.10 KOO29942.1 - 5 5.4 26.2 4.8 5.5 18.2 1.0 1 0 0 1 1 1 0 Daxx Family Tim54 PF11711.3 KOO29942.1 - 5.2 5.5 7.9 5.6 5.4 5.5 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Nop14 PF04147.7 KOO29942.1 - 5.7 4.7 29.0 6 4.6 20.1 1.0 1 0 0 1 1 1 0 Nop14-like family Pox_Ag35 PF03286.9 KOO29942.1 - 6.6 6.1 13.4 7.4 6.0 9.3 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein TRAP_alpha PF03896.11 KOO29942.1 - 6.7 5.6 19.1 7.4 5.4 13.3 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit VID27 PF08553.5 KOO29942.1 - 7.6 4.6 17.3 7.8 4.5 12.0 1.0 1 0 0 1 1 1 0 VID27 cytoplasmic protein BTV_NS2 PF04514.7 KOO29942.1 - 7.7 5.2 13.3 10 4.9 9.2 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Ycf1 PF05758.7 KOO29942.1 - 8.2 4.0 6.3 8 4.0 4.4 1.0 1 0 0 1 1 1 0 Ycf1 RNA_pol_3_Rpc31 PF11705.3 KOO29942.1 - 9 6.1 25.6 10 6.0 17.8 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 LysR_substrate PF03466.15 KOO29944.1 - 0.0072 15.4 1.4 0.12 11.4 0.1 2.3 2 0 0 2 2 2 2 LysR substrate binding domain Xpo1 PF08389.7 KOO29945.1 - 0.00023 21.0 0.0 0.00037 20.4 0.0 1.3 1 0 0 1 1 1 1 Exportin 1-like protein Spt4 PF06093.8 KOO29946.1 - 5.7e-20 70.9 0.0 7.8e-20 70.5 0.0 1.2 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Coronavirus_5 PF05528.6 KOO29946.1 - 0.0048 16.6 0.0 0.26 11.1 0.0 2.1 1 1 1 2 2 2 2 Coronavirus gene 5 protein LRR_6 PF13516.1 KOO29947.1 - 5.4e-20 69.1 8.9 0.27 11.4 0.0 10.8 13 0 0 13 13 13 6 Leucine Rich repeat LRR_1 PF00560.28 KOO29947.1 - 5.4e-09 34.8 0.0 1.4 9.2 0.1 6.6 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_4 PF12799.2 KOO29947.1 - 0.00015 21.3 0.0 4.9 6.8 0.0 5.5 6 0 0 6 6 6 1 Leucine Rich repeats (2 copies) Profilin PF00235.14 KOO29947.1 - 0.0014 18.7 3.6 19 5.3 0.0 5.1 5 0 0 5 5 5 0 Profilin LRR_8 PF13855.1 KOO29947.1 - 0.0084 15.8 0.0 63 3.4 0.0 5.4 6 0 0 6 6 6 0 Leucine rich repeat LRR_7 PF13504.1 KOO29947.1 - 0.013 15.5 4.3 3.5 8.2 0.1 5.3 6 0 0 6 6 6 0 Leucine rich repeat DUF3443 PF11925.3 KOO29947.1 - 0.026 13.1 2.2 20 3.7 0.0 4.4 5 0 0 5 5 5 0 Protein of unknown function (DUF3443) PAD_M PF08527.5 KOO29947.1 - 0.16 11.3 6.9 42 3.4 0.0 4.7 5 0 0 5 5 5 0 Protein-arginine deiminase (PAD) middle domain VCBS PF13517.1 KOO29948.1 - 2.2e-88 290.5 81.7 1.1e-13 51.3 3.9 10.0 5 3 4 9 9 9 9 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO29948.1 - 5.6e-60 197.7 131.0 1.1e-05 24.9 0.1 14.2 13 1 0 13 13 13 13 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO29948.1 - 9.1e-18 64.3 52.2 0.26 10.6 0.1 13.2 6 3 7 13 13 13 13 Insecticide toxin TcdB middle/N-terminal region GCC2_GCC3 PF07699.8 KOO29948.1 - 7.4e-15 54.2 49.4 1.3e-07 31.1 1.0 7.7 4 1 1 6 6 6 3 GCC2 and GCC3 DUF4589 PF15252.1 KOO29949.1 - 0.4 10.4 2.4 0.51 10.1 1.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4589) DP PF08781.5 KOO29950.1 - 1.6e-35 121.9 0.8 3e-35 120.9 0.6 1.4 1 0 0 1 1 1 1 Transcription factor DP E2F_TDP PF02319.15 KOO29950.1 - 5.1e-24 83.6 0.1 1e-23 82.6 0.1 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain CLASP_N PF12348.3 KOO29951.1 - 7.7e-26 90.8 0.0 3.4e-16 59.2 0.0 2.8 4 0 0 4 4 4 2 CLASP N terminal ATG16 PF08614.6 KOO29951.1 - 0.0071 16.1 6.5 0.0071 16.1 4.5 2.6 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) HEAT_EZ PF13513.1 KOO29951.1 - 0.0088 16.5 0.9 0.0088 16.5 0.6 5.2 4 1 1 5 5 5 1 HEAT-like repeat HEAT PF02985.17 KOO29951.1 - 0.15 12.2 0.2 0.15 12.2 0.1 5.3 7 0 0 7 7 7 0 HEAT repeat TBPIP PF07106.8 KOO29951.1 - 0.32 10.5 3.5 0.2 11.1 0.6 1.8 1 1 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Arm PF00514.18 KOO29951.1 - 0.73 9.7 5.6 7.9 6.4 0.1 3.9 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat V_ATPase_I PF01496.14 KOO29951.1 - 6.9 4.3 9.0 10 3.8 6.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Filamin PF00630.14 KOO29952.1 - 3.1e-35 120.7 0.0 1.5e-11 44.7 0.0 6.3 5 1 1 6 6 6 5 Filamin/ABP280 repeat MORN PF02493.15 KOO29953.1 - 1.8e-58 190.8 54.6 3e-08 32.9 1.2 10.8 11 0 0 11 11 11 10 MORN repeat ZZ PF00569.12 KOO29953.1 - 0.0057 16.1 0.0 0.014 14.8 0.0 1.7 1 0 0 1 1 1 1 Zinc finger, ZZ type TFIIIC_sub6 PF10419.4 KOO29953.1 - 0.028 13.8 28.0 3.2 7.2 0.2 8.9 9 0 0 9 9 9 0 TFIIIC subunit DUF1330 PF07045.6 KOO29953.1 - 8.9 6.2 11.2 1.7 8.5 0.1 5.2 5 3 2 7 7 7 0 Protein of unknown function (DUF1330) CAML PF14963.1 KOO29954.1 - 0.39 10.0 1.8 0.5 9.6 1.3 1.1 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand SAP PF02037.22 KOO29956.1 - 1.3e-05 24.5 0.8 3.1e-05 23.3 0.5 1.6 1 0 0 1 1 1 1 SAP domain DUF3138 PF11336.3 KOO29956.1 - 1.7 6.7 4.7 2.1 6.3 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) HalX PF08663.5 KOO29956.1 - 9.6 6.2 10.5 24 4.9 0.4 2.7 2 0 0 2 2 2 0 HalX domain FA_desaturase PF00487.19 KOO29957.1 - 6.6e-28 97.8 12.0 6.9e-28 97.7 8.0 1.3 1 1 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.23 KOO29957.1 - 4.6e-07 29.5 0.0 9.3e-07 28.5 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain EF-hand_1 PF00036.27 KOO29958.1 - 1e-10 40.1 3.2 1.7e-05 23.8 0.2 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO29958.1 - 8.4e-10 37.7 1.7 0.00058 19.5 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO29958.1 - 8.9e-10 38.5 0.8 3.3e-09 36.7 0.6 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO29958.1 - 1.2e-08 33.8 1.2 0.0015 17.7 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO29958.1 - 1.3e-08 34.3 1.0 3.9e-07 29.5 0.2 2.6 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO29958.1 - 0.029 14.4 0.2 0.054 13.5 0.1 1.6 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO29958.1 - 0.05 13.2 0.2 1.5 8.5 0.1 2.4 1 1 1 2 2 2 0 EF hand EF-hand_4 PF12763.2 KOO29958.1 - 0.06 13.0 1.5 0.49 10.1 0.9 2.2 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand SecA_DEAD PF07517.9 KOO29959.1 - 7.3e-13 48.4 0.0 1.6e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 SecA DEAD-like domain ResIII PF04851.10 KOO29959.1 - 0.09 12.6 0.0 0.32 10.8 0.0 1.9 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit WD40 PF00400.27 KOO29960.1 - 2.6e-13 49.2 1.5 0.017 14.9 0.0 5.4 6 0 0 6 6 6 3 WD domain, G-beta repeat PQQ_3 PF13570.1 KOO29960.1 - 0.068 13.4 1.1 36 4.8 0.0 4.5 4 1 0 4 4 4 0 PQQ-like domain PQQ_2 PF13360.1 KOO29960.1 - 0.075 12.4 0.7 4.4 6.6 0.0 2.5 1 1 1 2 2 2 0 PQQ-like domain DOT1 PF08123.8 KOO29961.1 - 3.7e-07 29.6 0.0 7e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Histone methylation protein DOT1 LRR_5 PF13306.1 KOO29964.1 - 1.2e-109 361.2 0.0 1.5e-32 112.0 0.0 4.6 2 1 2 4 4 4 4 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO29964.1 - 5.3e-31 106.1 0.1 0.0005 19.7 0.0 10.7 4 3 8 13 13 13 13 Leucine rich repeat TylF PF05711.6 KOO29966.1 - 1.7e-43 148.5 0.0 2.1e-43 148.2 0.0 1.1 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.1 KOO29966.1 - 1.8e-08 35.1 0.0 4.6e-08 33.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ank_2 PF12796.2 KOO29967.1 - 2.2e-33 114.4 0.4 1.6e-12 47.5 0.2 3.7 3 1 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO29967.1 - 1.6e-30 104.8 3.2 2e-08 34.4 0.6 4.7 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.25 KOO29967.1 - 6.2e-23 79.3 17.0 0.00012 21.6 2.4 6.8 6 1 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.1 KOO29967.1 - 9.9e-20 70.1 13.0 5.6e-06 26.4 1.3 6.2 3 3 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO29967.1 - 4e-17 60.6 2.3 0.039 14.1 0.0 7.4 7 0 0 7 7 7 4 Ankyrin repeat TylF PF05711.6 KOO29968.1 - 3.8e-29 101.5 0.0 6.9e-29 100.6 0.0 1.4 1 1 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.1 KOO29968.1 - 1.2e-05 26.1 0.0 2.6e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Peptidase_S8 PF00082.17 KOO29970.1 - 0.023 13.8 0.3 0.031 13.4 0.2 1.1 1 0 0 1 1 1 0 Subtilase family UCH PF00443.24 KOO29971.1 - 1.1e-07 31.3 0.0 1.4e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF1062 PF06353.7 KOO29971.1 - 0.097 12.8 0.0 0.35 11.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1062) ubiquitin PF00240.18 KOO29971.1 - 0.35 10.3 0.0 1.4 8.3 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin family zf-RING_2 PF13639.1 KOO29972.1 - 1.4e-10 40.8 2.3 2.9e-10 39.8 1.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 KOO29972.1 - 1.1e-07 31.4 1.7 2.2e-07 30.4 1.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 KOO29972.1 - 4.2e-07 29.8 2.9 9.2e-07 28.7 2.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO29972.1 - 4.2e-07 29.5 1.5 8.4e-07 28.5 1.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO29972.1 - 1.9e-06 27.4 1.3 3.9e-06 26.4 0.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 KOO29972.1 - 0.00013 21.6 0.5 0.00062 19.4 0.3 2.2 2 1 0 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.2 KOO29972.1 - 0.0011 18.9 0.3 0.0024 17.9 0.2 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_4 PF15227.1 KOO29972.1 - 0.0011 18.7 3.1 0.0094 15.8 2.3 2.2 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.1 KOO29972.1 - 0.0017 17.8 0.7 0.0056 16.2 0.5 1.9 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-Apc11 PF12861.2 KOO29972.1 - 0.05 13.4 0.8 0.15 11.8 0.6 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Rtf2 PF04641.7 KOO29972.1 - 0.051 12.7 0.7 0.11 11.6 0.2 1.7 1 1 1 2 2 2 0 Rtf2 RING-finger C1_1 PF00130.17 KOO29972.1 - 0.059 13.1 0.3 0.15 11.7 0.2 1.6 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF1644 PF07800.7 KOO29972.1 - 0.19 11.5 1.3 9.9 5.9 0.9 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) PSD5 PF07637.6 KOO29972.1 - 0.24 11.4 1.5 26 4.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1595) Prok-RING_1 PF14446.1 KOO29972.1 - 0.3 10.8 2.7 0.2 11.4 0.2 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Heme_oxygenase PF01126.15 KOO29973.1 - 4.9e-59 199.3 0.1 5.8e-59 199.0 0.0 1.1 1 0 0 1 1 1 1 Heme oxygenase CpeT PF06206.6 KOO29974.1 - 2.9e-14 53.1 0.0 3.6e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 CpeT/CpcT family (DUF1001) Flu_C_NS2 PF03555.9 KOO29974.1 - 0.0025 17.7 0.0 0.0047 16.8 0.0 1.4 1 0 0 1 1 1 1 Influenza C non-structural protein (NS2) TIR_2 PF13676.1 KOO29975.1 - 1.2e-14 54.2 0.0 7.9e-06 25.9 0.0 3.3 2 0 0 2 2 2 2 TIR domain Proteasom_PSMB PF10508.4 KOO29975.1 - 9e-06 24.2 5.1 0.033 12.4 0.1 4.2 6 1 0 6 6 6 2 Proteasome non-ATPase 26S subunit Arm PF00514.18 KOO29975.1 - 0.00018 21.2 24.7 0.27 11.1 0.0 12.3 15 0 0 15 15 15 1 Armadillo/beta-catenin-like repeat DUF2922 PF11148.3 KOO29975.1 - 0.0055 16.3 0.0 0.013 15.1 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2922) DUF3636 PF12331.3 KOO29975.1 - 0.028 13.9 0.4 1.6 8.3 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3636) TIR PF01582.15 KOO29975.1 - 0.2 11.0 0.0 13 5.2 0.0 2.4 2 0 0 2 2 2 0 TIR domain Npa1 PF11707.3 KOO29975.1 - 1.6 7.6 0.3 12 4.8 0.0 2.2 2 0 0 2 2 2 0 Ribosome 60S biogenesis N-terminal AAA PF00004.24 KOO29977.1 - 0.0019 18.4 0.2 0.0031 17.7 0.2 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PRKCSH-like PF12999.2 KOO29979.1 - 2.2e-22 79.4 8.9 4.8e-22 78.3 6.2 1.5 1 0 0 1 1 1 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.1 KOO29979.1 - 4.1e-16 58.8 0.0 1.4e-15 57.0 0.0 1.8 1 1 0 1 1 1 1 Glucosidase II beta subunit-like protein Chromo PF00385.19 KOO29981.1 - 1.2e-11 44.1 0.1 3.7e-11 42.5 0.1 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain PRO8NT PF08082.6 KOO29981.1 - 0.18 11.4 4.6 2.1 7.9 0.3 2.8 3 0 0 3 3 3 0 PRO8NT (NUC069), PrP8 N-terminal domain Topoisom_bac PF01131.15 KOO29982.1 - 9.8e-90 301.2 0.0 1.8e-62 211.4 0.0 2.0 1 1 1 2 2 2 2 DNA topoisomerase Toprim PF01751.17 KOO29982.1 - 1.3e-16 60.3 0.0 2.5e-16 59.4 0.0 1.5 1 0 0 1 1 1 1 Toprim domain SAP PF02037.22 KOO29982.1 - 7.2e-10 38.1 0.4 1.6e-09 37.0 0.3 1.6 1 0 0 1 1 1 1 SAP domain Toprim_4 PF13662.1 KOO29982.1 - 0.00011 22.1 0.0 0.00065 19.6 0.0 2.4 2 1 0 2 2 2 1 Toprim domain DNA_binding_1 PF01035.15 KOO29982.1 - 0.098 12.4 1.6 2.9 7.6 0.0 3.2 2 1 1 3 3 3 0 6-O-methylguanine DNA methyltransferase, DNA binding domain DUF4326 PF14216.1 KOO29983.1 - 0.001 19.5 0.3 0.014 15.9 0.1 2.9 2 1 0 2 2 2 1 Domain of unknown function (DUF4326) NAD_binding_8 PF13450.1 KOO29984.1 - 8.6e-11 41.7 1.5 1.1e-10 41.3 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOO29984.1 - 0.0043 15.9 0.6 0.0069 15.3 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Amino_oxidase PF01593.19 KOO29984.1 - 0.0057 15.7 1.5 0.1 11.6 0.1 2.1 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.1 KOO29984.1 - 0.037 13.7 0.0 0.083 12.6 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding PARP PF00644.15 KOO29985.1 - 1.3e-14 54.1 0.0 1.5e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain ABC_membrane PF00664.18 KOO29988.1 - 4.5e-20 72.2 13.9 6.3e-19 68.4 4.2 2.2 1 1 1 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 KOO29988.1 - 6.2e-12 45.9 0.0 1.4e-11 44.8 0.0 1.6 1 0 0 1 1 1 1 ABC transporter UBA PF00627.26 KOO29989.1 - 3.1e-07 30.0 0.2 7.9e-07 28.7 0.1 1.7 1 0 0 1 1 1 1 UBA/TS-N domain Ras PF00071.17 KOO29989.1 - 0.00018 20.9 0.0 0.0003 20.2 0.0 1.4 1 0 0 1 1 1 1 Ras family CUE PF02845.11 KOO29989.1 - 0.077 12.5 0.1 0.17 11.3 0.0 1.6 2 0 0 2 2 2 0 CUE domain cobW PF02492.14 KOO29991.1 - 0.0002 20.8 0.0 0.00024 20.5 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain PepSY_2 PF13670.1 KOO29991.1 - 0.08 12.8 1.2 4.4 7.2 0.1 2.3 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain SGT1 PF07093.6 KOO29992.1 - 0.0058 15.0 2.1 0.0064 14.9 1.4 1.0 1 0 0 1 1 1 1 SGT1 protein Syntaphilin PF15290.1 KOO29992.1 - 0.12 11.8 3.0 0.1 12.0 1.1 1.5 2 0 0 2 2 2 0 Golgi-localised syntaxin-1-binding clamp HisKA_2 PF07568.7 KOO29992.1 - 0.16 11.8 1.1 0.3 10.9 0.8 1.4 1 0 0 1 1 1 0 Histidine kinase RR_TM4-6 PF06459.7 KOO29992.1 - 0.26 11.1 4.2 0.32 10.8 2.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SAP PF02037.22 KOO29993.1 - 3.9e-08 32.6 2.0 8.1e-08 31.5 1.4 1.5 1 0 0 1 1 1 1 SAP domain BID PF06393.6 KOO29993.1 - 0.0064 15.8 2.2 0.011 15.0 1.5 1.3 1 0 0 1 1 1 1 BH3 interacting domain (BID) DUF2360 PF10152.4 KOO29993.1 - 3.6 7.8 5.9 7.3 6.8 4.1 1.5 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) SAM_MT PF04445.8 KOO29994.1 - 0.12 11.5 0.0 9.1 5.3 0.0 2.8 2 1 1 3 3 3 0 Putative SAM-dependent methyltransferase Ank_4 PF13637.1 KOO29995.1 - 1e-10 41.8 0.6 2.1e-07 31.2 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO29995.1 - 1.7e-09 37.8 0.0 3e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO29995.1 - 3.6e-09 36.5 0.2 9.8e-09 35.1 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.25 KOO29995.1 - 4.7e-09 35.6 0.1 5.4e-07 29.1 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.1 KOO29995.1 - 0.00031 20.7 0.0 0.004 17.2 0.0 2.6 3 0 0 3 3 3 1 Ankyrin repeat Glyco_hydro_2_C PF02836.12 KOO29996.1 - 2.9e-77 259.5 0.0 1.1e-76 257.6 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.13 KOO29996.1 - 9.7e-45 152.1 0.0 1.6e-44 151.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.16 KOO29996.1 - 8.1e-08 32.6 0.0 1.9e-07 31.4 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_72 PF03198.9 KOO29996.1 - 0.023 13.7 0.0 0.037 13.0 0.0 1.2 1 0 0 1 1 1 0 Glucanosyltransferase Glyco_hydro_42 PF02449.10 KOO29996.1 - 0.11 11.6 0.0 0.3 10.1 0.0 1.6 2 0 0 2 2 2 0 Beta-galactosidase zf-RING_2 PF13639.1 KOO29997.1 - 1.3e-14 53.7 2.5 1.3e-14 53.7 1.8 1.8 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.2 KOO29997.1 - 6.3e-10 39.0 2.0 7.7e-10 38.7 0.6 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 KOO29997.1 - 1.1e-08 34.9 2.0 1.1e-08 34.9 1.4 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO29997.1 - 2.4e-07 30.3 1.2 2.4e-07 30.3 0.8 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO29997.1 - 4.4e-07 29.5 1.0 4.4e-07 29.5 0.7 1.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.20 KOO29997.1 - 4.7e-07 29.3 0.6 4.7e-07 29.3 0.4 1.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 KOO29997.1 - 3.5e-06 26.7 0.6 6.7e-06 25.8 0.4 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 KOO29997.1 - 0.0015 18.0 2.2 0.0015 18.0 1.5 1.5 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.1 KOO29997.1 - 0.0074 15.9 2.9 0.5 10.1 0.1 2.4 2 0 0 2 2 2 2 RING-type zinc-finger FANCL_C PF11793.3 KOO29997.1 - 0.026 14.4 5.9 0.57 10.1 4.1 2.6 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.1 KOO29997.1 - 0.035 13.9 2.6 0.035 13.9 1.8 2.3 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING RINGv PF12906.2 KOO29997.1 - 0.06 13.3 2.4 0.27 11.3 1.7 2.1 1 1 0 1 1 1 0 RING-variant domain zf-Nse PF11789.3 KOO29997.1 - 0.088 12.3 1.1 0.28 10.7 0.1 2.0 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Baculo_RING PF05883.6 KOO29997.1 - 0.2 11.4 0.8 0.41 10.4 0.5 1.4 1 1 0 1 1 1 0 Baculovirus U-box/Ring-like domain PCI_Csn8 PF10075.4 KOO29998.1 - 3.6e-21 75.4 0.0 4.6e-21 75.1 0.0 1.1 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 SAC3_GANP PF03399.11 KOO29998.1 - 1.8e-15 57.0 0.0 2.3e-15 56.7 0.0 1.1 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family DUF2079 PF09852.4 KOO29998.1 - 0.047 12.4 0.0 0.058 12.1 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2079) DUF563 PF04577.9 KOO29999.1 - 1.5e-11 44.6 0.0 2.1e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Chromo PF00385.19 KOO30000.1 - 0.15 11.7 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain DUF4189 PF13827.1 KOO30003.1 - 0.048 13.9 0.1 0.11 12.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4189) 2OG-FeII_Oxy_3 PF13640.1 KOO30004.1 - 6.7e-09 36.1 0.0 1.2e-08 35.3 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO30004.1 - 0.0034 16.9 0.0 0.0066 16.0 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PhyH PF05721.8 KOO30004.1 - 0.08 12.9 0.0 2.6 8.0 0.1 2.1 2 0 0 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) Lactamase_B_4 PF13691.1 KOO30005.1 - 4.1e-05 22.9 0.0 8.5e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 tRNase Z endonuclease PSI_PSAK PF01241.13 KOO30006.1 - 2.1e-05 24.4 1.2 2.1e-05 24.4 0.8 1.9 2 0 0 2 2 2 1 Photosystem I psaG / psaK Romo1 PF10247.4 KOO30006.1 - 0.092 12.9 2.5 0.16 12.1 1.7 1.5 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 DUF4345 PF14248.1 KOO30006.1 - 1.2 8.6 6.8 0.67 9.4 3.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4345) Lactamase_B_2 PF12706.2 KOO30007.1 - 8.7e-32 110.2 0.0 1.9e-31 109.1 0.0 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 KOO30007.1 - 1.8e-06 27.7 3.5 1.4e-05 24.8 2.4 2.3 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily DUF2188 PF09954.4 KOO30007.1 - 0.037 13.9 0.7 0.49 10.3 0.1 3.0 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2188) SPRY PF00622.23 KOO30008.1 - 1.1e-07 31.9 0.0 1.6e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 SPRY domain Succ_CoA_lig PF13607.1 KOO30009.1 - 0.13 11.8 0.1 0.13 11.8 0.1 1.9 2 1 1 3 3 3 0 Succinyl-CoA ligase like flavodoxin domain LRR_4 PF12799.2 KOO30010.1 - 8.1e-21 73.1 0.0 1.6e-08 33.9 0.1 3.7 2 2 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO30010.1 - 4.9e-14 51.8 0.1 9.7e-07 28.4 0.0 2.6 2 1 0 2 2 2 2 Leucine rich repeat LRR_7 PF13504.1 KOO30010.1 - 6.9e-08 31.4 3.8 4.8 7.8 0.0 6.4 7 0 0 7 7 7 2 Leucine rich repeat LRR_9 PF14580.1 KOO30010.1 - 8.5e-07 28.6 0.0 6.2e-06 25.8 0.0 2.0 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.28 KOO30010.1 - 1e-06 27.9 0.0 5 7.5 0.0 5.3 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_6 PF13516.1 KOO30010.1 - 0.00044 20.0 0.9 1.1 9.5 0.1 4.4 3 1 1 4 4 4 1 Leucine Rich repeat IncA PF04156.9 KOO30010.1 - 0.004 16.7 1.0 0.0067 16.0 0.7 1.3 1 0 0 1 1 1 1 IncA protein Uds1 PF15456.1 KOO30010.1 - 0.055 13.4 7.6 0.14 12.1 5.3 1.6 1 0 0 1 1 1 0 Up-regulated During Septation YlqD PF11068.3 KOO30011.1 - 0.049 13.6 2.0 0.069 13.1 0.7 1.7 1 1 0 1 1 1 0 YlqD protein DUF1136 PF06582.7 KOO30011.1 - 0.12 12.1 0.5 0.54 9.9 0.4 2.2 1 0 0 1 1 1 0 Repeat of unknown function (DUF1136) OEP PF02321.13 KOO30011.1 - 1.1 8.7 26.5 1.9 8.0 6.2 2.1 1 1 1 2 2 2 0 Outer membrane efflux protein CENP-Q PF13094.1 KOO30011.1 - 3.6 7.6 12.0 0.13 12.3 2.4 2.2 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit TMF_DNA_bd PF12329.3 KOO30011.1 - 3.7 7.4 6.8 4.2 7.2 0.1 3.1 2 2 2 4 4 4 0 TATA element modulatory factor 1 DNA binding DUF3829 PF12889.2 KOO30011.1 - 4.3 6.4 9.1 5.1 6.1 6.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) Dapper PF15268.1 KOO30011.1 - 5.8 5.5 9.2 6.5 5.4 6.4 1.2 1 0 0 1 1 1 0 Dapper Rad60-SLD PF11976.3 KOO30012.1 - 0.00014 21.4 0.0 0.00022 20.8 0.0 1.3 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 KOO30012.1 - 0.00018 20.8 0.0 0.00031 20.0 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.1 KOO30012.1 - 0.0032 17.3 0.0 0.0037 17.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Nuc_sug_transp PF04142.10 KOO30013.1 - 3.3e-52 177.0 0.8 3.3e-52 177.0 0.5 1.6 2 0 0 2 2 2 1 Nucleotide-sugar transporter EamA PF00892.15 KOO30013.1 - 0.00034 20.6 7.2 0.00034 20.6 5.0 2.8 2 1 0 2 2 2 1 EamA-like transporter family EmrE PF13536.1 KOO30013.1 - 0.0026 17.9 5.0 0.0026 17.9 3.4 3.7 3 0 0 3 3 3 1 Multidrug resistance efflux transporter TPT PF03151.11 KOO30013.1 - 0.022 14.4 11.1 0.21 11.2 3.4 2.8 2 1 0 2 2 2 0 Triose-phosphate Transporter family DUF1675 PF07897.6 KOO30014.1 - 1.9 8.2 14.5 3.1 7.5 10.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) FUSC PF04632.7 KOO30014.1 - 3.3 6.0 16.7 6 5.1 11.6 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family HAUS6_N PF14661.1 KOO30014.1 - 4.5 6.5 22.9 7.6 5.8 15.9 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus SpoU_methylase PF00588.14 KOO30016.1 - 7.3e-15 55.0 0.0 1e-14 54.5 0.0 1.2 1 0 0 1 1 1 1 SpoU rRNA Methylase family Isochorismatase PF00857.15 KOO30017.1 - 6.7e-25 88.0 0.1 1.6e-24 86.7 0.1 1.7 1 1 0 1 1 1 1 Isochorismatase family EF-hand_1 PF00036.27 KOO30017.1 - 2.1e-09 35.9 1.2 0.00029 19.9 0.1 3.0 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO30017.1 - 2.5e-08 33.1 0.4 0.0055 16.4 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO30017.1 - 1.8e-06 27.9 0.1 6.2e-06 26.2 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO30017.1 - 1.9e-06 26.9 0.1 0.0014 17.9 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO30017.1 - 0.00012 21.5 1.4 0.0014 18.2 0.4 2.8 2 1 1 3 3 3 2 EF-hand domain pair RIIa PF02197.12 KOO30017.1 - 0.004 16.5 0.0 0.0087 15.4 0.0 1.6 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit SPARC_Ca_bdg PF10591.4 KOO30017.1 - 0.049 13.6 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Filamin PF00630.14 KOO30018.1 - 8.9e-25 87.2 0.0 1.5e-19 70.3 0.0 2.1 2 0 0 2 2 2 2 Filamin/ABP280 repeat Big_1 PF02369.11 KOO30018.1 - 0.0013 18.5 0.0 0.0027 17.5 0.0 1.5 1 0 0 1 1 1 1 Bacterial Ig-like domain (group 1) Big_3_4 PF13754.1 KOO30018.1 - 0.0035 17.6 1.5 0.0075 16.5 0.6 1.8 1 1 1 2 2 2 1 Bacterial Ig-like domain (group 3) DUF2744 PF10910.3 KOO30020.1 - 0.0052 16.6 0.3 0.011 15.6 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2744) Pyr_redox_2 PF07992.9 KOO30022.1 - 0.032 14.1 0.0 0.11 12.3 0.0 1.9 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF824 PF05688.6 KOO30022.1 - 0.08 12.5 0.3 0.33 10.6 0.0 2.2 2 0 0 2 2 2 0 Salmonella repeat of unknown function (DUF824) Pyr_redox PF00070.22 KOO30022.1 - 0.17 12.3 0.8 2.5 8.5 0.0 3.0 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DUF4407 PF14362.1 KOO30022.1 - 2 7.3 13.1 3.3 6.5 9.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) EF-hand_7 PF13499.1 KOO30023.1 - 2.6e-46 155.6 28.7 9.9e-10 38.4 0.0 7.2 5 2 1 6 6 6 6 EF-hand domain pair EF-hand_1 PF00036.27 KOO30023.1 - 8.5e-46 149.8 42.9 5.2e-05 22.2 0.1 12.6 13 0 0 13 13 13 12 EF hand EF-hand_6 PF13405.1 KOO30023.1 - 4.1e-45 147.6 34.5 0.00023 20.8 0.0 12.5 12 0 0 12 12 12 11 EF-hand domain EF-hand_8 PF13833.1 KOO30023.1 - 2.8e-30 103.6 33.9 5.9e-08 32.2 0.0 9.7 6 5 5 11 11 11 9 EF-hand domain pair EF-hand_5 PF13202.1 KOO30023.1 - 1.6e-28 96.6 33.7 0.00023 20.3 0.1 11.6 11 0 0 11 11 11 9 EF hand EF-hand_9 PF14658.1 KOO30023.1 - 3e-05 23.8 0.0 7.2 6.5 0.0 5.4 4 1 2 6 6 6 1 EF-hand domain UPF0158 PF03682.8 KOO30023.1 - 0.0012 18.5 3.0 0.03 13.9 0.1 2.5 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0158) EF-hand_10 PF14788.1 KOO30023.1 - 0.0035 16.9 2.5 34 4.1 0.0 6.5 6 1 1 7 7 7 0 EF hand EF-hand_4 PF12763.2 KOO30023.1 - 0.0081 15.8 28.0 5.3 6.8 0.3 9.0 6 3 5 11 11 11 2 Cytoskeletal-regulatory complex EF hand Toprim_2 PF13155.1 KOO30023.1 - 0.0086 16.3 3.4 53 4.2 0.0 5.1 4 2 1 5 5 4 0 Toprim-like Hormone_6 PF00236.13 KOO30023.1 - 0.05 13.4 0.1 15 5.4 0.0 2.4 2 0 0 2 2 2 0 Glycoprotein hormone Lipase_GDSL_2 PF13472.1 KOO30023.1 - 0.077 13.1 0.1 15 5.6 0.0 2.7 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase family SPARC_Ca_bdg PF10591.4 KOO30023.1 - 0.097 12.7 16.7 5 7.2 0.1 6.8 5 3 1 7 7 7 0 Secreted protein acidic and rich in cysteine Ca binding region Peptidase_S49_N PF08496.5 KOO30023.1 - 5.8 6.6 15.1 5.3 6.8 0.7 4.1 4 0 0 4 4 4 0 Peptidase family S49 N-terminal TUDOR PF00567.19 KOO30025.1 - 7.7e-08 32.2 1.8 2e-07 30.9 0.0 2.4 2 1 1 3 3 3 1 Tudor domain SMN PF06003.7 KOO30025.1 - 2.9e-05 23.3 0.1 2.9e-05 23.3 0.1 2.4 1 1 1 2 2 2 1 Survival motor neuron protein (SMN) Chromo PF00385.19 KOO30026.1 - 7.3e-10 38.3 0.0 1.1e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Acetyltransf_1 PF00583.19 KOO30027.1 - 0.00014 21.7 0.2 0.00029 20.8 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 KOO30027.1 - 0.00017 21.6 0.2 0.00038 20.5 0.2 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain SET PF00856.23 KOO30027.1 - 0.0018 18.6 0.0 0.0029 17.9 0.0 1.4 1 0 0 1 1 1 1 SET domain Acetyltransf_7 PF13508.1 KOO30027.1 - 0.013 15.6 0.0 0.022 14.9 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain LRR_6 PF13516.1 KOO30028.1 - 3.5e-15 54.3 0.0 0.012 15.6 0.0 5.0 5 0 0 5 5 5 4 Leucine Rich repeat LRR_4 PF12799.2 KOO30028.1 - 0.00018 21.0 0.0 0.033 13.8 0.0 2.8 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO30028.1 - 0.0039 17.0 0.0 70 4.0 0.0 4.2 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_7 PF13504.1 KOO30028.1 - 0.0041 17.0 0.1 55 4.6 0.0 4.2 4 0 0 4 4 4 0 Leucine rich repeat LRR_8 PF13855.1 KOO30028.1 - 0.15 11.8 0.1 14 5.5 0.1 3.6 2 1 0 2 2 2 0 Leucine rich repeat DUF1014 PF06244.7 KOO30032.1 - 6.5e-26 90.9 0.4 7.3e-26 90.7 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1014) DUF3126 PF11324.3 KOO30032.1 - 0.0048 16.5 0.1 0.0092 15.6 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3126) PA-IIL PF07472.6 KOO30032.1 - 0.12 12.6 0.1 0.19 11.9 0.1 1.4 1 1 0 1 1 1 0 Fucose-binding lectin II (PA-IIL) Melibiase PF02065.13 KOO30033.1 - 0.0001 21.1 0.0 0.00016 20.5 0.0 1.2 1 0 0 1 1 1 1 Melibiase Glyco_hydro_97 PF10566.4 KOO30033.1 - 0.00025 20.2 0.0 0.0004 19.5 0.0 1.2 1 0 0 1 1 1 1 Glycoside hydrolase 97 Glyco_hydro_2_N PF02837.13 KOO30034.1 - 1.9e-11 43.7 0.0 5.2e-11 42.3 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.12 KOO30034.1 - 1.7e-08 33.7 0.0 3.2e-06 26.2 0.0 2.3 2 0 0 2 2 2 2 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.16 KOO30034.1 - 1.5e-06 28.6 0.0 1.5e-06 28.6 0.0 3.0 2 2 0 2 2 2 1 Glycosyl hydrolases family 2 GDI PF00996.13 KOO30035.1 - 3.4e-147 490.2 0.0 4.4e-147 489.9 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Aminotran_1_2 PF00155.16 KOO30036.1 - 4.4e-39 134.4 0.0 5.5e-39 134.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 KOO30036.1 - 0.003 16.7 0.0 0.0046 16.1 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase FKBP_C PF00254.23 KOO30037.1 - 2.4e-57 190.9 0.0 2.2e-27 94.8 0.0 2.4 2 0 0 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_11 PF13414.1 KOO30037.1 - 8.8e-06 25.2 0.4 0.00063 19.3 0.0 2.5 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 KOO30037.1 - 3.9e-05 23.2 0.1 0.0016 18.2 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO30037.1 - 7.1e-05 22.2 0.1 0.0013 18.2 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO30037.1 - 0.0074 16.8 0.2 0.042 14.5 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOO30037.1 - 0.021 14.6 0.2 0.054 13.3 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.1 KOO30037.1 - 0.022 15.4 0.3 0.42 11.3 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO30037.1 - 0.025 15.0 0.0 0.46 11.0 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO30037.1 - 0.025 14.5 0.0 0.16 11.9 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Aldose_epim PF01263.15 KOO30038.1 - 5.1e-74 249.0 0.0 6e-74 248.8 0.0 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase Tad PF13400.1 KOO30038.1 - 0.031 14.3 0.9 0.059 13.4 0.6 1.5 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like Nrap PF03813.9 KOO30039.1 - 5.8e-24 83.7 1.1 1.5e-11 42.6 0.1 2.1 2 0 0 2 2 2 2 Nrap protein Pribosyltran_N PF13793.1 KOO30040.1 - 2.2e-45 153.1 0.0 2.4e-44 149.7 0.0 2.5 3 0 0 3 3 3 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 KOO30040.1 - 3.3e-28 98.6 0.1 1.5e-27 96.5 0.1 1.9 1 1 1 2 2 2 1 Phosphoribosyl synthetase-associated domain SPX PF03105.14 KOO30040.1 - 1.3e-23 84.2 6.2 4.1e-09 36.6 0.0 3.1 2 1 0 2 2 2 2 SPX domain Pribosyltran PF00156.22 KOO30040.1 - 9.8e-09 35.0 0.1 1.2e-07 31.5 0.1 2.3 2 0 0 2 2 2 1 Phosphoribosyl transferase domain RseA_N PF03872.8 KOO30040.1 - 0.072 13.4 0.4 0.19 12.0 0.2 1.7 1 0 0 1 1 1 0 Anti sigma-E protein RseA, N-terminal domain TelA PF05816.6 KOO30041.1 - 0.012 14.3 0.3 0.015 14.0 0.2 1.1 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) Cast PF10174.4 KOO30041.1 - 0.016 13.2 1.7 0.02 12.9 1.2 1.0 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone Arfaptin PF06456.8 KOO30041.1 - 0.037 13.3 0.2 0.047 13.0 0.1 1.1 1 0 0 1 1 1 0 Arfaptin-like domain IncA PF04156.9 KOO30041.1 - 0.038 13.5 1.4 0.047 13.2 1.0 1.1 1 0 0 1 1 1 0 IncA protein Speriolin_N PF15058.1 KOO30041.1 - 0.24 11.2 5.6 0.46 10.3 3.9 1.5 1 1 0 1 1 1 0 Speriolin N terminus ABC1 PF03109.11 KOO30042.1 - 6.6e-32 109.9 0.1 1.6e-31 108.7 0.1 1.7 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 KOO30042.1 - 0.0052 16.5 0.2 0.31 10.7 0.2 3.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family Prominin PF05478.6 KOO30042.1 - 0.23 8.9 0.0 0.41 8.1 0.0 1.3 1 0 0 1 1 1 0 Prominin UPF0160 PF03690.8 KOO30043.1 - 1.3e-93 313.9 0.0 6.3e-93 311.6 0.0 2.0 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0160) SpoU_methylase PF00588.14 KOO30044.1 - 1.1e-35 122.6 0.0 1.5e-35 122.0 0.0 1.2 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.7 KOO30044.1 - 0.0072 16.4 0.0 0.022 14.9 0.0 1.8 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding LRAT PF04970.8 KOO30045.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Lecithin retinol acyltransferase Pro_isomerase PF00160.16 KOO30046.1 - 1.7e-42 145.2 0.4 2.2e-42 144.9 0.2 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Tubulin PF00091.20 KOO30047.1 - 2.7e-67 226.7 0.0 3.7e-67 226.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.1 KOO30047.1 - 0.029 13.8 0.0 0.05 13.0 0.0 1.3 1 0 0 1 1 1 0 Tubulin domain LSM PF01423.17 KOO30048.1 - 4.1e-16 58.2 0.9 4.8e-16 58.0 0.6 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 KOO30048.1 - 0.043 13.7 0.1 0.053 13.4 0.1 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Flag1_repress PF03614.8 KOO30048.1 - 0.057 12.9 0.1 0.1 12.1 0.0 1.4 1 1 0 1 1 1 0 Repressor of phase-1 flagellin Metallophos PF00149.23 KOO30049.1 - 0.0024 17.3 0.0 0.0029 17.0 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase UcrQ PF02939.11 KOO30050.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 UcrQ family Ank_2 PF12796.2 KOO30051.1 - 6.1e-07 29.6 0.3 9.4e-07 29.0 0.2 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO30051.1 - 4.3e-05 23.8 0.2 0.016 15.6 0.0 1.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO30051.1 - 0.014 15.6 0.0 0.049 13.8 0.0 1.9 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Ank PF00023.25 KOO30051.1 - 0.061 13.1 0.0 0.75 9.7 0.0 2.5 3 0 0 3 3 3 0 Ankyrin repeat TGS PF02824.16 KOO30051.1 - 0.068 13.0 0.8 0.17 11.7 0.1 2.0 2 1 0 2 2 2 0 TGS domain Aminotran_1_2 PF00155.16 KOO30052.1 - 2.4e-18 66.2 0.0 2.9e-18 65.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 KOO30052.1 - 8.5e-05 21.8 0.0 0.00011 21.4 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 KOO30052.1 - 0.0023 17.0 0.1 0.03 13.3 0.0 2.3 3 0 0 3 3 3 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_MocR PF12897.2 KOO30052.1 - 0.0031 16.1 0.0 0.005 15.4 0.0 1.3 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase RraB PF06877.6 KOO30053.1 - 2.2 8.9 13.0 1.6 9.4 1.4 3.0 1 1 1 2 2 2 0 Regulator of ribonuclease activity B MRP-S27 PF10037.4 KOO30053.1 - 3.5 6.4 16.6 4.5 6.0 11.5 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 AAA PF00004.24 KOO30054.1 - 1.1e-38 132.4 0.0 1.7e-38 131.7 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 KOO30054.1 - 6.1e-20 70.8 0.0 2e-19 69.2 0.0 2.0 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.7 KOO30054.1 - 1.1e-07 31.1 0.0 1.8e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 KOO30054.1 - 1.1e-06 28.7 0.4 0.0012 18.8 0.0 2.5 1 1 1 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 KOO30054.1 - 1.4e-06 28.5 0.3 0.0024 17.9 0.0 2.6 2 1 1 3 3 3 2 AAA domain AAA_2 PF07724.9 KOO30054.1 - 4.6e-06 26.6 0.0 7.3e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_25 PF13481.1 KOO30054.1 - 5.3e-06 25.9 0.7 0.054 12.8 0.1 2.4 1 1 1 2 2 2 2 AAA domain AAA_17 PF13207.1 KOO30054.1 - 8.4e-06 26.6 0.0 1.9e-05 25.4 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_5 PF07728.9 KOO30054.1 - 3.1e-05 23.7 0.1 0.00038 20.1 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 KOO30054.1 - 5.3e-05 22.7 0.0 9.6e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.1 KOO30054.1 - 0.00024 20.9 0.0 0.00085 19.2 0.0 2.1 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.8 KOO30054.1 - 0.00026 19.8 0.0 0.00042 19.1 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_19 PF13245.1 KOO30054.1 - 0.0004 20.0 0.1 0.0015 18.2 0.0 2.1 2 0 0 2 2 1 1 Part of AAA domain AAA_14 PF13173.1 KOO30054.1 - 0.00049 19.9 0.0 0.00084 19.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOO30054.1 - 0.0016 18.7 0.0 0.0027 18.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain Bac_DnaA PF00308.13 KOO30054.1 - 0.003 17.2 0.0 0.0067 16.0 0.0 1.7 1 1 0 1 1 1 1 Bacterial dnaA protein DUF815 PF05673.8 KOO30054.1 - 0.003 16.5 0.0 0.0041 16.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RNA_helicase PF00910.17 KOO30054.1 - 0.0031 17.6 0.0 0.0052 16.9 0.0 1.4 1 0 0 1 1 1 1 RNA helicase Arch_ATPase PF01637.13 KOO30054.1 - 0.0057 16.3 0.0 0.029 14.0 0.0 1.8 1 1 1 2 2 2 1 Archaeal ATPase NACHT PF05729.7 KOO30054.1 - 0.0093 15.6 0.1 0.14 11.8 0.0 2.2 1 1 0 2 2 2 1 NACHT domain AAA_24 PF13479.1 KOO30054.1 - 0.011 15.3 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 KOO30054.1 - 0.012 14.8 0.1 0.04 13.0 0.0 1.8 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 KOO30054.1 - 0.02 13.9 0.0 0.034 13.2 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_3 PF07726.6 KOO30054.1 - 0.026 14.1 0.0 0.05 13.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.12 KOO30054.1 - 0.027 13.3 0.0 0.046 12.5 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Sigma54_activ_2 PF14532.1 KOO30054.1 - 0.048 13.7 0.0 0.09 12.8 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_28 PF13521.1 KOO30054.1 - 0.048 13.6 0.1 0.14 12.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.1 KOO30054.1 - 0.06 12.9 0.0 0.089 12.3 0.0 1.3 1 1 0 1 1 1 0 AAA domain PhoH PF02562.11 KOO30054.1 - 0.072 12.3 0.1 0.16 11.2 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein CPT PF07931.7 KOO30054.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein NTPase_1 PF03266.10 KOO30054.1 - 0.14 11.8 0.1 2 8.1 0.0 2.2 2 0 0 2 2 2 0 NTPase Myb_DNA-bind_5 PF13873.1 KOO30055.1 - 0.00083 19.1 0.1 0.00085 19.1 0.1 1.0 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-binding PF00249.26 KOO30055.1 - 0.048 13.7 0.2 0.051 13.6 0.1 1.1 1 0 0 1 1 1 0 Myb-like DNA-binding domain RPA_interact_N PF14766.1 KOO30055.1 - 0.17 11.3 1.2 0.27 10.7 0.3 1.9 1 1 1 2 2 2 0 Replication protein A interacting N-terminal Acetyltransf_10 PF13673.1 KOO30057.1 - 0.063 13.4 0.1 0.095 12.8 0.1 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 KOO30057.1 - 0.11 12.3 0.0 0.27 11.1 0.0 1.6 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase ABC1 PF03109.11 KOO30059.1 - 6.2e-26 90.7 0.1 2.3e-25 88.8 0.0 2.0 2 0 0 2 2 2 1 ABC1 family Pkinase PF00069.20 KOO30059.1 - 0.22 10.6 0.0 12 4.9 0.0 2.4 2 0 0 2 2 2 0 Protein kinase domain Ion_trans PF00520.26 KOO30060.1 - 1.1e-29 103.1 17.3 1.6e-29 102.5 12.0 1.3 1 0 0 1 1 1 1 Ion transport protein Abhydrolase_2 PF02230.11 KOO30060.1 - 4.9e-08 32.6 0.1 2.3e-05 23.9 0.0 2.3 1 1 1 2 2 2 2 Phospholipase/Carboxylesterase PIH1 PF08190.7 KOO30060.1 - 8.6e-05 22.1 0.0 0.00013 21.5 0.0 1.2 1 0 0 1 1 1 1 pre-RNA processing PIH1/Nop17 Peptidase_S9 PF00326.16 KOO30060.1 - 0.0051 16.0 0.0 0.0083 15.3 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family PKD_channel PF08016.7 KOO30060.1 - 0.022 13.2 11.8 0.082 11.3 1.7 2.2 2 0 0 2 2 2 0 Polycystin cation channel DLH PF01738.13 KOO30060.1 - 0.13 11.4 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 KOO30060.1 - 0.15 11.7 0.1 0.39 10.4 0.1 1.6 1 1 1 2 2 2 0 Alpha/beta hydrolase family Adeno_PX PF05829.7 KOO30060.1 - 1.5 8.3 5.2 10 5.7 0.1 2.6 2 0 0 2 2 2 0 Adenovirus late L2 mu core protein (Protein X) Ion_trans PF00520.26 KOO30061.1 - 9.7e-33 113.0 14.2 9.7e-33 113.0 9.8 1.4 2 0 0 2 2 2 1 Ion transport protein EF-hand_1 PF00036.27 KOO30061.1 - 0.0012 17.9 0.0 0.0045 16.1 0.0 2.1 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO30061.1 - 0.0041 17.2 0.0 0.0098 16.0 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair PKD_channel PF08016.7 KOO30061.1 - 0.0042 15.5 20.5 0.098 11.0 1.6 2.7 2 1 0 2 2 2 2 Polycystin cation channel EF-hand_6 PF13405.1 KOO30061.1 - 0.025 14.4 0.0 0.15 12.0 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain EF-hand_5 PF13202.1 KOO30061.1 - 0.084 12.2 0.0 0.24 10.8 0.0 1.8 1 0 0 1 1 1 0 EF hand PP-binding PF00550.20 KOO30062.1 - 4e-12 46.2 0.0 6.2e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site TPR_12 PF13424.1 KOO30063.1 - 4.5e-62 205.9 31.1 1.3e-14 53.8 0.8 4.6 1 1 5 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.1 KOO30063.1 - 4.5e-26 89.9 27.3 7.6e-10 38.3 0.4 6.7 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_1 PF00515.23 KOO30063.1 - 1.4e-22 78.3 7.3 3.4e-06 26.4 0.1 6.1 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.1 KOO30063.1 - 6.8e-21 73.7 4.8 1.2e-07 31.2 0.1 3.7 2 1 1 3 3 3 3 TPR repeat TPR_2 PF07719.12 KOO30063.1 - 2e-14 52.2 18.8 0.00016 21.2 0.1 5.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.1 KOO30063.1 - 5.6e-14 50.7 7.3 0.036 13.8 0.0 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_19 PF14559.1 KOO30063.1 - 2.3e-08 34.2 6.1 0.015 15.6 0.3 4.0 1 1 2 4 4 4 4 Tetratricopeptide repeat TPR_16 PF13432.1 KOO30063.1 - 4.8e-08 33.4 15.2 0.011 16.3 1.1 4.2 2 2 3 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO30063.1 - 1.7e-07 31.2 19.4 0.016 15.7 0.4 5.6 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_4 PF07721.9 KOO30063.1 - 8.9e-07 28.7 5.4 0.017 15.5 0.3 4.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO30063.1 - 3.3e-06 26.4 7.2 0.26 11.1 0.0 4.4 6 0 0 6 6 4 3 Tetratricopeptide repeat Apc3 PF12895.2 KOO30063.1 - 5.3e-06 26.4 0.1 0.005 16.9 0.0 2.7 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 SHNi-TPR PF10516.4 KOO30063.1 - 2.8e-05 23.2 1.9 0.002 17.3 0.0 3.3 4 0 0 4 4 4 1 SHNi-TPR TPR_17 PF13431.1 KOO30063.1 - 0.00095 19.1 0.1 10 6.6 0.0 4.0 3 1 0 3 3 3 0 Tetratricopeptide repeat SNAP PF14938.1 KOO30063.1 - 0.0019 17.3 0.6 0.2 10.7 0.1 2.4 1 1 1 2 2 2 1 Soluble NSF attachment protein, SNAP HDOD PF08668.7 KOO30063.1 - 0.068 12.4 0.8 0.47 9.7 0.1 2.6 1 1 1 2 2 2 0 HDOD domain MIT PF04212.13 KOO30063.1 - 0.077 12.8 0.6 5.9 6.8 0.0 3.1 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_3 PF07720.7 KOO30063.1 - 0.2 11.5 1.2 23 4.9 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO30063.1 - 0.59 10.7 18.3 1.9 9.1 0.2 5.8 6 1 0 6 6 5 0 Tetratricopeptide repeat His_Phos_1 PF00300.17 KOO30064.1 - 4e-10 39.9 0.0 6.2e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DM PF00751.13 KOO30066.1 - 0.091 12.3 0.7 0.19 11.2 0.5 1.5 1 0 0 1 1 1 0 DM DNA binding domain Chordopox_RPO7 PF05864.7 KOO30066.1 - 0.11 12.6 2.0 0.76 9.9 0.3 2.9 2 1 1 3 3 3 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) WD40 PF00400.27 KOO30068.1 - 1.6e-35 119.6 11.2 2.7e-10 39.7 0.0 5.3 5 0 0 5 5 5 5 WD domain, G-beta repeat eIF2A PF08662.6 KOO30068.1 - 4.1e-06 26.6 0.0 0.0057 16.3 0.0 2.7 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 KOO30068.1 - 0.13 10.3 3.1 2.9 5.9 0.1 2.3 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Mg-por_mtran_C PF07109.6 KOO30068.1 - 0.15 12.1 0.0 0.45 10.5 0.0 1.8 2 0 0 2 2 2 0 Magnesium-protoporphyrin IX methyltransferase C-terminus Methyltransf_26 PF13659.1 KOO30069.1 - 3.4e-05 23.8 0.0 5.1e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO30069.1 - 6.5e-05 23.4 0.0 0.00013 22.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO30069.1 - 0.014 15.1 0.0 0.019 14.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain SAYSvFN PF10260.4 KOO30072.1 - 1.2e-11 44.2 0.0 1.7e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved domain (SAYSvFN) Peptidase_S8 PF00082.17 KOO30073.1 - 6.5e-21 74.7 0.6 2.2e-20 72.9 0.3 1.8 2 0 0 2 2 2 1 Subtilase family DCP1 PF06058.8 KOO30074.1 - 4.3e-36 123.6 0.0 6.4e-36 123.1 0.0 1.2 1 0 0 1 1 1 1 Dcp1-like decapping family Ran_BP1 PF00638.13 KOO30074.1 - 0.084 12.9 0.0 3.6 7.6 0.0 2.2 2 0 0 2 2 2 0 RanBP1 domain LZ_Tnp_IS66 PF13007.2 KOO30074.1 - 9.8 6.9 9.9 23 5.7 1.2 2.4 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain TFIIB PF00382.14 KOO30075.1 - 1.3e-32 111.3 1.1 1.5e-15 56.7 0.0 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 KOO30075.1 - 1.3e-13 50.0 2.6 2.5e-13 49.1 1.8 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding zf-ribbon_3 PF13248.1 KOO30075.1 - 0.00049 19.2 0.6 0.0012 18.0 0.4 1.7 1 0 0 1 1 1 1 zinc-ribbon domain BRF1 PF07741.8 KOO30075.1 - 0.00086 19.4 0.4 0.0025 18.0 0.3 1.8 1 0 0 1 1 1 1 Brf1-like TBP-binding domain CDC37_N PF03234.9 KOO30075.1 - 0.007 16.7 1.2 0.013 15.8 0.8 1.4 1 0 0 1 1 1 1 Cdc37 N terminal kinase binding Prim_Zn_Ribbon PF08273.7 KOO30075.1 - 0.014 15.4 3.0 0.036 14.1 2.1 1.7 1 0 0 1 1 1 0 Zinc-binding domain of primase-helicase zinc_ribbon_2 PF13240.1 KOO30075.1 - 0.023 14.1 2.3 0.057 12.9 1.6 1.7 1 0 0 1 1 1 0 zinc-ribbon domain DUF1204 PF06721.6 KOO30075.1 - 0.055 12.7 5.2 0.033 13.4 1.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1204) DUF479 PF04336.7 KOO30075.1 - 0.056 13.5 1.6 0.42 10.7 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function, DUF479 DZR PF12773.2 KOO30075.1 - 0.072 12.9 2.3 0.2 11.5 1.6 1.7 1 0 0 1 1 1 0 Double zinc ribbon Lar_restr_allev PF14354.1 KOO30075.1 - 0.082 13.2 1.4 0.24 11.7 1.0 1.8 1 0 0 1 1 1 0 Restriction alleviation protein Lar A2L_zn_ribbon PF08792.5 KOO30075.1 - 0.12 11.8 3.5 0.24 10.8 2.4 1.5 1 0 0 1 1 1 0 A2L zinc ribbon domain RRN7 PF11781.3 KOO30075.1 - 0.15 11.6 4.1 0.34 10.4 2.9 1.7 1 0 0 1 1 1 0 RNA polymerase I-specific transcription initiation factor Rrn7 OrfB_Zn_ribbon PF07282.6 KOO30075.1 - 0.16 11.6 1.6 0.32 10.6 1.1 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Kri1 PF05178.7 KOO30075.1 - 0.23 11.7 5.4 0.44 10.8 3.7 1.4 1 0 0 1 1 1 0 KRI1-like family FYDLN_acid PF09538.5 KOO30075.1 - 1.7 9.2 5.8 9.5 6.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Caudo_TAP PF02413.12 KOO30075.1 - 4.6 7.4 9.5 3.4 7.8 4.9 2.0 2 1 0 2 2 1 0 Caudovirales tail fibre assembly protein EF-hand_1 PF00036.27 KOO30076.1 - 2.4e-28 95.2 11.3 6.6e-07 28.1 0.2 5.8 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.1 KOO30076.1 - 6.6e-26 89.6 1.0 1.2e-08 34.4 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO30076.1 - 2.1e-25 86.2 12.1 5.5e-06 25.8 0.1 6.4 6 0 0 6 6 6 6 EF-hand domain EF-hand_7 PF13499.1 KOO30076.1 - 5.2e-24 84.1 5.0 2.2e-10 40.5 0.1 4.6 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO30076.1 - 5.6e-24 82.3 18.1 7.8e-07 28.1 0.1 6.1 6 0 0 6 6 6 5 EF hand SPARC_Ca_bdg PF10591.4 KOO30076.1 - 0.1 12.6 0.0 38 4.3 0.0 3.6 4 0 0 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region DUF4546 PF15079.1 KOO30076.1 - 0.28 10.2 1.4 3.5 6.7 0.1 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4546) SHOCT PF09851.4 KOO30076.1 - 5.8 6.5 7.4 6.8 6.3 0.3 4.0 4 0 0 4 4 4 0 Short C-terminal domain Peptidase_S8 PF00082.17 KOO30078.1 - 7.6e-35 120.4 0.4 1.3e-34 119.7 0.3 1.2 1 0 0 1 1 1 1 Subtilase family XPC-binding PF09280.6 KOO30079.1 - 9.2e-06 25.0 0.6 5.2e-05 22.6 0.1 2.2 2 0 0 2 2 2 1 XPC-binding domain UBA PF00627.26 KOO30079.1 - 0.00027 20.6 0.0 0.0019 17.9 0.0 2.1 2 0 0 2 2 2 1 UBA/TS-N domain zf-B_box PF00643.19 KOO30079.1 - 0.37 10.7 4.7 0.44 10.4 1.6 2.2 2 0 0 2 2 2 0 B-box zinc finger DUF3499 PF12005.3 KOO30080.1 - 0.028 14.5 3.1 0.14 12.3 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3499) Taxilin PF09728.4 KOO30080.1 - 0.029 13.4 0.1 0.029 13.4 0.1 3.6 2 1 2 4 4 4 0 Myosin-like coiled-coil protein HisKA PF00512.20 KOO30080.1 - 0.063 13.2 4.1 2.8 8.0 0.2 3.4 1 1 1 2 2 2 0 His Kinase A (phospho-acceptor) domain DUF4559 PF15112.1 KOO30080.1 - 0.26 10.4 4.1 0.3 10.2 0.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4559) Vac_Fusion PF02346.11 KOO30080.1 - 0.52 9.7 3.5 3.8 6.9 0.0 3.3 3 0 0 3 3 3 0 Chordopoxvirus fusion protein TMF_TATA_bd PF12325.3 KOO30080.1 - 0.6 9.8 14.2 0.17 11.6 1.7 3.3 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF972 PF06156.8 KOO30080.1 - 2.8 8.3 10.7 3.3 8.1 0.1 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF972) Baculo_PEP_C PF04513.7 KOO30080.1 - 7.3 6.4 8.4 11 5.8 0.6 3.2 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Troponin PF00992.15 KOO30080.1 - 9.7 6.2 19.6 2.6 8.0 2.0 3.1 3 0 0 3 3 3 0 Troponin Pyr_redox_2 PF07992.9 KOO30081.1 - 9.6e-45 152.9 2.5 1.4e-44 152.3 1.7 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 KOO30081.1 - 3.4e-40 136.5 1.9 7e-40 135.4 0.5 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 KOO30081.1 - 1.5e-22 79.7 7.7 1.2e-18 67.2 0.2 4.0 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOO30081.1 - 1.2e-11 45.0 0.8 1.5e-06 28.4 0.3 3.1 1 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 KOO30081.1 - 1.4e-11 44.1 3.8 5.8e-10 38.8 0.8 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.17 KOO30081.1 - 4.3e-10 39.0 6.5 4.3e-09 35.7 2.0 2.7 2 1 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_8 PF13450.1 KOO30081.1 - 1.3e-09 37.9 3.2 0.0005 20.0 0.4 3.2 3 0 0 3 3 3 2 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 KOO30081.1 - 6.1e-09 35.2 11.2 4.6e-06 25.7 0.6 3.6 4 0 0 4 4 4 2 FAD binding domain HI0933_like PF03486.9 KOO30081.1 - 1.8e-05 23.3 11.9 0.00024 19.6 1.0 3.5 4 0 0 4 4 4 2 HI0933-like protein K_oxygenase PF13434.1 KOO30081.1 - 7e-05 21.8 0.9 0.14 11.0 0.0 2.6 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) AlaDh_PNT_C PF01262.16 KOO30081.1 - 7.5e-05 22.3 2.6 0.061 12.8 0.1 2.5 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.12 KOO30081.1 - 8.9e-05 21.6 0.2 8.9e-05 21.6 0.1 2.9 2 1 1 3 3 3 1 Thi4 family FAD_binding_3 PF01494.14 KOO30081.1 - 0.00011 21.4 3.3 0.023 13.7 0.4 2.3 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 KOO30081.1 - 0.017 14.0 15.3 0.033 13.0 0.3 3.7 4 0 0 4 4 4 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 KOO30081.1 - 0.054 12.4 2.6 0.11 11.4 0.0 2.4 3 0 0 3 3 3 0 Lycopene cyclase protein 3HCDH_N PF02737.13 KOO30081.1 - 0.097 12.3 0.1 0.097 12.3 0.1 2.6 2 1 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.1 KOO30081.1 - 0.15 12.3 0.3 5.3 7.3 0.1 2.6 2 0 0 2 2 2 0 Putative NAD(P)-binding tRNA-synt_2 PF00152.15 KOO30082.1 - 5.1e-55 186.5 0.0 9e-35 120.0 0.0 3.1 2 1 1 3 3 3 3 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 KOO30082.1 - 1.5e-10 40.7 0.2 2.6e-10 39.9 0.1 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain WHEP-TRS PF00458.15 KOO30082.1 - 2.4e-09 36.7 2.7 5.2e-09 35.6 1.8 1.6 1 0 0 1 1 1 1 WHEP-TRS domain tRNA-synt_2d PF01409.15 KOO30082.1 - 0.026 13.7 0.1 1.4 8.0 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) Pro_racemase PF05544.6 KOO30083.1 - 2.5e-90 302.6 0.0 4.8e-90 301.6 0.0 1.4 1 1 0 1 1 1 1 Proline racemase DAP_epimerase PF01678.14 KOO30083.1 - 0.0042 17.0 0.0 0.43 10.5 0.1 2.3 2 0 0 2 2 2 2 Diaminopimelate epimerase TTL PF03133.10 KOO30084.1 - 3.2e-84 282.3 0.0 4.5e-84 281.8 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 KOO30084.1 - 0.0046 15.7 0.0 0.16 10.7 0.0 2.7 2 1 1 3 3 3 1 YheC/D like ATP-grasp ATP-grasp_3 PF02655.9 KOO30084.1 - 0.017 15.0 0.0 0.18 11.6 0.0 2.4 2 1 1 3 3 3 0 ATP-grasp domain Ubiquitin_3 PF14836.1 KOO30085.1 - 0.087 12.5 1.2 2.5 7.8 0.1 2.8 2 2 0 2 2 2 0 Ubiquitin-like domain DUF3983 PF13137.1 KOO30085.1 - 0.14 11.8 1.5 4.1 7.1 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3983) MscS_porin PF12795.2 KOO30085.1 - 2 7.7 8.3 0.36 10.1 1.2 2.1 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain MerR-DNA-bind PF09278.6 KOO30085.1 - 7 7.1 9.5 6.4 7.2 1.5 3.5 2 2 2 4 4 4 0 MerR, DNA binding EF-hand_1 PF00036.27 KOO30086.1 - 1e-33 112.0 11.3 4.7e-09 34.8 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO30086.1 - 8.4e-28 96.3 9.1 1.5e-15 57.0 0.3 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO30086.1 - 4.2e-26 88.4 10.0 4.9e-09 35.3 0.0 4.9 4 2 1 5 5 5 4 EF-hand domain EF-hand_8 PF13833.1 KOO30086.1 - 1.5e-25 88.5 11.4 3e-12 45.9 0.2 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO30086.1 - 6.6e-24 82.1 9.1 3.6e-06 26.0 0.2 4.7 4 1 1 5 5 5 4 EF hand EF-hand_9 PF14658.1 KOO30086.1 - 7.2e-13 48.2 0.1 4.7e-07 29.6 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 KOO30086.1 - 2e-06 27.4 4.0 0.16 11.7 0.6 3.6 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO30086.1 - 0.001 19.0 0.2 1.6 8.7 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region LETM1 PF07766.8 KOO30086.1 - 0.01 14.9 0.2 0.014 14.4 0.1 1.3 1 0 0 1 1 1 0 LETM1-like protein Toprim_2 PF13155.1 KOO30086.1 - 0.011 15.9 1.6 3.5 7.9 0.0 2.4 1 1 1 2 2 2 0 Toprim-like Caleosin PF05042.8 KOO30086.1 - 0.014 14.9 0.1 5.6 6.4 0.0 2.5 2 1 0 2 2 2 0 Caleosin related protein OST-HTH PF12872.2 KOO30086.1 - 0.04 13.7 0.0 16 5.4 0.0 3.2 3 1 1 4 4 4 0 OST-HTH/LOTUS domain Acetyltransf_11 PF13720.1 KOO30086.1 - 0.043 14.0 0.3 1.9 8.7 0.0 2.4 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 DUF3008 PF11450.3 KOO30086.1 - 0.069 13.2 4.0 0.1 12.7 0.1 2.9 4 0 0 4 4 2 0 Protein of unknwon function (DUF3008) TerB PF05099.8 KOO30086.1 - 0.072 12.8 1.6 4.8 6.9 0.2 2.6 1 1 1 2 2 2 0 Tellurite resistance protein TerB DUF21 PF01595.15 KOO30086.1 - 0.098 11.9 0.2 0.7 9.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF21 TyeA PF09059.5 KOO30086.1 - 0.1 12.5 0.1 0.44 10.5 0.0 1.9 2 0 0 2 2 2 0 TyeA UPF0154 PF03672.8 KOO30086.1 - 0.14 11.8 0.6 10 5.8 0.0 3.3 4 0 0 4 4 4 0 Uncharacterised protein family (UPF0154) PMBR PF09373.5 KOO30086.1 - 0.14 12.1 0.2 19 5.4 0.0 4.2 6 0 0 6 6 6 0 Pseudomurein-binding repeat Endonuc-dimeris PF09124.5 KOO30086.1 - 0.24 11.0 3.6 4.2 7.0 0.0 2.9 3 0 0 3 3 3 0 T4 recombination endonuclease VII, dimerisation DUF4373 PF14297.1 KOO30086.1 - 0.32 11.3 2.5 58 4.0 0.1 3.5 1 1 3 4 4 4 0 Domain of unknown function (DUF4373) MgtE_N PF03448.12 KOO30086.1 - 0.34 11.2 2.5 0.64 10.3 0.1 2.3 2 1 0 2 2 2 0 MgtE intracellular N domain EF-hand_10 PF14788.1 KOO30086.1 - 0.75 9.5 3.3 9.9 5.9 0.3 2.8 2 1 1 3 3 3 0 EF hand IQ PF00612.22 KOO30087.1 - 9.6e-05 21.7 0.2 0.0048 16.4 0.0 2.6 2 0 0 2 2 2 1 IQ calmodulin-binding motif PX PF00787.19 KOO30087.1 - 0.0015 18.3 0.0 0.0023 17.6 0.0 1.2 1 0 0 1 1 1 1 PX domain Mg_trans_NIPA PF05653.9 KOO30088.1 - 3.5e-14 52.4 7.9 5.3e-14 51.8 5.5 1.2 1 0 0 1 1 1 1 Magnesium transporter NIPA UPF0546 PF10639.4 KOO30088.1 - 0.046 13.5 0.5 0.046 13.5 0.4 1.8 2 0 0 2 2 2 0 Uncharacterised protein family UPF0546 FtsX PF02687.16 KOO30088.1 - 0.07 12.8 0.2 0.07 12.8 0.2 3.2 3 2 0 3 3 3 0 FtsX-like permease family DctQ PF04290.7 KOO30088.1 - 4.7 6.9 19.4 0.082 12.6 4.3 3.2 3 1 1 4 4 4 0 Tripartite ATP-independent periplasmic transporters, DctQ component PgaD PF13994.1 KOO30088.1 - 5.1 6.5 10.2 0.21 11.0 0.6 2.5 2 0 0 2 2 2 0 PgaD-like protein TMP-TENI PF02581.12 KOO30089.1 - 9.7e-45 151.8 2.7 1.8e-44 151.0 1.9 1.4 1 0 0 1 1 1 1 Thiamine monophosphate synthase/TENI Phos_pyr_kin PF08543.7 KOO30089.1 - 1.1e-29 103.3 0.6 1.8e-29 102.6 0.0 1.6 2 0 0 2 2 2 1 Phosphomethylpyrimidine kinase DUF561 PF04481.7 KOO30089.1 - 0.029 13.3 0.0 0.072 12.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF561) Mg_trans_NIPA PF05653.9 KOO30091.1 - 0.00018 20.5 3.1 0.002 17.1 0.1 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA CitMHS PF03600.11 KOO30091.1 - 0.0086 14.6 0.0 0.014 14.0 0.0 1.3 1 1 0 1 1 1 1 Citrate transporter EamA PF00892.15 KOO30091.1 - 0.026 14.5 1.1 0.026 14.5 0.7 3.1 3 1 0 3 3 3 0 EamA-like transporter family EmrE PF13536.1 KOO30091.1 - 4.2 7.6 10.5 1.1 9.5 1.1 3.2 3 0 0 3 3 3 0 Multidrug resistance efflux transporter VDE PF07137.6 KOO30092.1 - 3.7e-72 242.3 0.9 5.2e-72 241.8 0.6 1.2 1 0 0 1 1 1 1 Violaxanthin de-epoxidase (VDE) DUF2771 PF10969.3 KOO30092.1 - 0.091 12.0 0.1 0.15 11.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2771) TylF PF05711.6 KOO30093.1 - 6.1e-21 74.6 0.0 7.1e-21 74.4 0.0 1.2 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.1 KOO30093.1 - 9e-06 26.4 0.0 1.3e-05 25.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain FAD_binding_3 PF01494.14 KOO30094.1 - 6.1e-19 68.2 0.0 1e-18 67.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain SE PF08491.5 KOO30094.1 - 0.00054 18.8 0.0 0.01 14.6 0.0 2.0 2 0 0 2 2 2 1 Squalene epoxidase Lycopene_cycl PF05834.7 KOO30094.1 - 0.0054 15.6 0.0 0.0054 15.6 0.0 2.2 3 0 0 3 3 3 1 Lycopene cyclase protein PseudoU_synth_2 PF00849.17 KOO30095.1 - 6.6e-28 97.6 0.0 1.1e-27 96.8 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.20 KOO30095.1 - 1.3e-05 24.4 0.1 6e-05 22.3 0.0 2.1 2 0 0 2 2 2 1 S4 domain S4_2 PF13275.1 KOO30095.1 - 0.0031 17.0 0.0 0.007 15.9 0.0 1.5 1 0 0 1 1 1 1 S4 domain DUF1242 PF06842.7 KOO30095.1 - 0.063 12.7 0.0 0.18 11.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1242) Methyltransf_16 PF10294.4 KOO30096.1 - 2.6e-09 36.7 0.0 3.7e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Na_H_Exchanger PF00999.16 KOO30097.1 - 3.3e-42 144.3 18.0 4.9e-42 143.8 12.5 1.3 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DUF4404 PF14357.1 KOO30097.1 - 0.091 13.1 0.3 0.47 10.9 0.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) UCH PF00443.24 KOO30098.1 - 3.1e-29 101.9 0.0 4.4e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.26 KOO30098.1 - 1.2e-13 50.4 3.7 5.4e-08 32.4 0.1 3.1 3 0 0 3 3 3 2 UBA/TS-N domain zf-UBP PF02148.14 KOO30098.1 - 5.8e-08 32.7 0.0 1.1e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.1 KOO30098.1 - 0.00018 21.0 0.0 0.00028 20.4 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UIM PF02809.15 KOO30098.1 - 0.065 12.8 0.7 0.21 11.2 0.5 1.9 1 0 0 1 1 1 0 Ubiquitin interaction motif Ank PF00023.25 KOO30100.1 - 6.8e-22 76.1 6.9 2.4e-08 33.3 0.1 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.2 KOO30100.1 - 7e-19 67.9 2.4 1.1e-18 67.3 1.7 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO30100.1 - 1.5e-16 60.4 4.1 2.7e-07 30.8 0.1 2.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO30100.1 - 1.5e-11 43.3 3.5 0.001 19.1 0.1 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.1 KOO30100.1 - 2.6e-10 40.2 5.5 0.00027 21.0 0.2 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) NUDIX PF00293.23 KOO30101.1 - 1.2e-10 41.1 0.0 1.2e-09 37.8 0.0 2.5 2 0 0 2 2 2 1 NUDIX domain EF-hand_6 PF13405.1 KOO30101.1 - 0.00055 19.5 0.0 0.0019 17.9 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.27 KOO30101.1 - 0.0029 16.8 0.0 0.0064 15.7 0.0 1.6 1 0 0 1 1 1 1 EF hand Ion_trans PF00520.26 KOO30101.1 - 0.0079 15.4 0.8 0.014 14.6 0.6 1.4 1 0 0 1 1 1 1 Ion transport protein EF-hand_7 PF13499.1 KOO30101.1 - 0.085 13.0 0.0 0.22 11.6 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair DUF4473 PF14747.1 KOO30102.1 - 0.032 14.4 0.1 0.12 12.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4473) Ribosomal_L18_c PF14204.1 KOO30102.1 - 0.13 12.8 0.9 0.16 12.5 0.2 1.5 2 0 0 2 2 2 0 Ribosomal L18 C-terminal region RNA_pol_N PF01194.12 KOO30103.1 - 1.4e-29 101.9 1.2 1.9e-29 101.4 0.8 1.2 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.7 KOO30103.1 - 0.036 14.1 0.5 0.056 13.5 0.3 1.3 1 1 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Yippee-Mis18 PF03226.9 KOO30103.1 - 0.095 12.7 0.5 0.15 12.0 0.1 1.6 1 1 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Cytochrom_B561 PF03188.11 KOO30104.1 - 8.1e-22 77.5 12.2 8.1e-22 77.5 8.5 1.7 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 PepSY_TM PF03929.11 KOO30104.1 - 0.24 11.8 0.0 0.24 11.8 0.0 5.0 5 1 0 5 5 5 0 PepSY-associated TM helix DUF3040 PF11239.3 KOO30104.1 - 0.59 10.2 0.1 0.59 10.2 0.1 4.1 3 2 1 4 4 4 0 Protein of unknown function (DUF3040) DUF4407 PF14362.1 KOO30104.1 - 9.8 5.0 6.9 2.4 7.0 1.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) PA28_beta PF02252.13 KOO30107.1 - 0.0019 17.6 0.0 0.0032 16.9 0.0 1.4 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit Peptidase_M16_C PF05193.16 KOO30107.1 - 0.11 12.1 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Peptidase M16 inactive domain YusW PF14039.1 KOO30107.1 - 0.11 12.7 0.8 0.21 11.8 0.1 1.8 2 1 0 2 2 2 0 YusW-like protein MHCassoc_trimer PF08831.5 KOO30107.1 - 0.18 11.6 1.9 5.1 7.0 0.0 2.7 2 1 1 3 3 3 0 Class II MHC-associated invariant chain trimerisation domain gag_pre-integrs PF13976.1 KOO30108.1 - 0.001 18.6 2.0 0.0013 18.2 0.1 1.9 2 0 0 2 2 2 1 GAG-pre-integrase domain DUF3275 PF11679.3 KOO30109.1 - 1.2 8.7 4.3 2.6 7.6 3.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) LRR_6 PF13516.1 KOO30111.1 - 1.9e-14 52.0 0.2 0.0083 16.0 0.0 5.9 5 0 0 5 5 5 4 Leucine Rich repeat NACHT PF05729.7 KOO30111.1 - 0.00029 20.5 0.0 0.00064 19.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain LRR_4 PF12799.2 KOO30111.1 - 0.0063 16.1 1.2 2 8.1 0.1 3.9 3 2 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO30111.1 - 0.77 10.2 3.8 1.5e+02 3.3 0.0 5.3 6 0 0 6 6 6 0 Leucine rich repeat BSP_II PF05432.6 KOO30113.1 - 0.0031 16.8 7.0 0.0031 16.8 4.9 1.0 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) PBP1_TM PF14812.1 KOO30113.1 - 0.0041 17.3 13.8 0.0071 16.6 9.6 1.4 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Nucleoplasmin PF03066.10 KOO30113.1 - 0.024 14.1 13.8 0.028 13.9 9.6 1.2 1 0 0 1 1 1 0 Nucleoplasmin DNA_pol_phi PF04931.8 KOO30113.1 - 0.043 11.6 13.1 0.045 11.5 9.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi Trypan_PARP PF05887.6 KOO30113.1 - 0.06 13.1 4.2 0.064 13.0 2.9 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) CENP-B_dimeris PF09026.5 KOO30113.1 - 0.067 13.4 14.2 0.084 13.1 9.9 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sigma70_ner PF04546.8 KOO30113.1 - 0.078 12.5 10.5 0.086 12.4 7.3 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region eIF-3c_N PF05470.7 KOO30113.1 - 0.098 10.7 6.9 0.11 10.6 4.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus NOA36 PF06524.7 KOO30113.1 - 0.12 11.5 8.4 0.13 11.4 5.8 1.1 1 0 0 1 1 1 0 NOA36 protein Dicty_REP PF05086.7 KOO30113.1 - 0.13 10.0 13.3 0.14 9.8 9.2 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Rhabdo_ncap PF00945.13 KOO30113.1 - 0.13 10.7 3.2 0.14 10.7 2.2 1.0 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein DUF2796 PF10986.3 KOO30113.1 - 0.14 12.1 1.8 0.14 12.1 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) RXT2_N PF08595.6 KOO30113.1 - 0.16 11.7 9.3 0.18 11.6 6.4 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal EBV-NA3 PF05009.7 KOO30113.1 - 0.21 10.8 6.5 0.24 10.6 4.5 1.0 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) FAM176 PF14851.1 KOO30113.1 - 0.25 10.9 7.3 0.29 10.8 5.0 1.1 1 0 0 1 1 1 0 FAM176 family Myc_N PF01056.13 KOO30113.1 - 0.32 10.1 9.1 0.35 9.9 6.3 1.1 1 0 0 1 1 1 0 Myc amino-terminal region DUF3464 PF11947.3 KOO30113.1 - 0.47 9.8 2.6 0.52 9.7 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3464) Sporozoite_P67 PF05642.6 KOO30113.1 - 0.54 8.0 7.5 0.54 8.0 5.2 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Voldacs PF03517.8 KOO30113.1 - 0.67 9.7 5.4 0.71 9.7 3.7 1.2 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling SspB PF04386.8 KOO30113.1 - 0.93 9.0 4.3 1 8.9 3.0 1.1 1 0 0 1 1 1 0 Stringent starvation protein B Daxx PF03344.10 KOO30113.1 - 1.1 7.6 12.5 1.2 7.5 8.7 1.0 1 0 0 1 1 1 0 Daxx Family TLP-20 PF06088.6 KOO30113.1 - 1.2 8.8 6.1 1.3 8.6 4.2 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Pox_Ag35 PF03286.9 KOO30113.1 - 1.5 8.3 9.0 1.7 8.1 6.2 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein BTV_NS2 PF04514.7 KOO30113.1 - 1.8 7.3 8.3 1.7 7.4 5.7 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Paf1 PF03985.8 KOO30113.1 - 2 7.0 10.0 2 7.0 6.9 1.0 1 0 0 1 1 1 0 Paf1 FLO_LFY PF01698.11 KOO30113.1 - 2.3 7.0 7.9 2.5 6.8 5.5 1.0 1 0 0 1 1 1 0 Floricaula / Leafy protein CDC45 PF02724.9 KOO30113.1 - 2.4 6.0 11.4 2.6 5.9 7.9 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF1510 PF07423.6 KOO30113.1 - 2.5 7.4 10.7 2.5 7.3 7.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Cwf_Cwc_15 PF04889.7 KOO30113.1 - 2.7 7.6 16.3 3.1 7.4 11.3 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Vfa1 PF08432.5 KOO30113.1 - 3 7.8 9.2 3.4 7.6 6.4 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Nop14 PF04147.7 KOO30113.1 - 3.3 5.5 14.6 3.5 5.4 10.1 1.0 1 0 0 1 1 1 0 Nop14-like family Tom22 PF04281.8 KOO30113.1 - 3.8 7.0 7.8 4.3 6.8 5.4 1.3 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 Retinal PF15449.1 KOO30113.1 - 4.3 4.8 7.1 4.9 4.6 4.9 1.0 1 0 0 1 1 1 0 Retinal protein Nucleo_P87 PF07267.6 KOO30113.1 - 4.8 5.7 12.4 5.1 5.6 8.6 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 VID27 PF08553.5 KOO30113.1 - 5 5.2 9.5 4.9 5.2 6.6 1.0 1 0 0 1 1 1 0 VID27 cytoplasmic protein Tim54 PF11711.3 KOO30113.1 - 5.1 5.5 6.6 5.4 5.5 4.5 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TRAP_alpha PF03896.11 KOO30113.1 - 6.1 5.7 9.3 6.5 5.6 6.5 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF3449 PF11931.3 KOO30113.1 - 6.4 6.2 6.8 7.5 6.0 4.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) HSP90 PF00183.13 KOO30113.1 - 7.2 4.8 9.1 6.9 4.9 6.3 1.0 1 0 0 1 1 1 0 Hsp90 protein LRR_5 PF13306.1 KOO30114.1 - 4.9e-67 223.5 0.2 1.3e-36 125.1 0.0 2.1 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO30114.1 - 1.2e-24 85.7 0.0 1.4e-06 27.8 0.0 4.6 1 1 3 4 4 4 4 Leucine rich repeat ZF-HD_dimer PF04770.7 KOO30114.1 - 2.4 8.3 4.6 11 6.0 0.0 3.2 3 0 0 3 3 3 0 ZF-HD protein dimerisation region Mitoc_L55 PF09776.4 KOO30115.1 - 0.019 14.5 0.1 37 3.9 0.0 3.7 1 1 3 4 4 4 0 Mitochondrial ribosomal protein L55 EF-hand_7 PF13499.1 KOO30116.1 - 2.4e-18 65.9 0.1 3.6e-08 33.4 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO30116.1 - 2.4e-15 54.9 1.4 0.00041 19.9 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.27 KOO30116.1 - 1.1e-14 52.4 0.1 5.9e-05 22.0 0.0 4.4 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.1 KOO30116.1 - 1.2e-12 46.5 0.4 0.0011 18.2 0.0 4.5 4 0 0 4 4 4 2 EF hand GPS PF01825.16 KOO30116.1 - 5.1e-11 42.5 3.0 1.1e-10 41.4 2.1 1.6 1 0 0 1 1 1 1 Latrophilin/CL-1-like GPS domain EF-hand_8 PF13833.1 KOO30116.1 - 0.00039 19.9 0.1 0.26 10.9 0.0 3.3 2 2 2 4 4 4 2 EF-hand domain pair DUF2217 PF10265.4 KOO30116.1 - 0.019 13.7 2.7 0.031 13.0 1.9 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) SPARC_Ca_bdg PF10591.4 KOO30116.1 - 0.049 13.6 1.0 0.92 9.5 0.0 2.6 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region rve PF00665.21 KOO30118.1 - 1.7e-08 34.5 0.0 6.2e-08 32.7 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain RVT_2 PF07727.9 KOO30118.1 - 2.4e-07 29.9 0.0 1.3e-06 27.5 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Gelsolin PF00626.17 KOO30121.1 - 2e-44 149.1 0.0 4.2e-10 39.1 0.0 6.9 7 0 0 7 7 7 6 Gelsolin repeat VHP PF02209.14 KOO30121.1 - 3.4e-13 49.0 3.4 6.2e-13 48.1 2.3 1.5 1 0 0 1 1 1 1 Villin headpiece domain EF-hand_1 PF00036.27 KOO30121.1 - 4.7e-07 28.6 4.1 0.0002 20.4 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO30121.1 - 4.5e-06 26.0 2.0 0.00075 19.1 0.0 3.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.1 KOO30121.1 - 0.00014 21.4 0.1 0.014 15.0 0.0 2.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO30121.1 - 0.00014 21.0 0.0 0.00014 21.0 0.0 2.8 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.1 KOO30121.1 - 0.00019 21.5 0.7 0.0014 18.7 0.5 2.4 1 1 0 1 1 1 1 EF-hand domain pair Ank_3 PF13606.1 KOO30121.1 - 0.00022 21.1 0.6 45 4.7 0.0 5.5 5 0 0 5 5 5 0 Ankyrin repeat Ank_2 PF12796.2 KOO30121.1 - 0.0021 18.3 0.0 2 8.8 0.0 3.4 2 1 1 3 3 3 1 Ankyrin repeats (3 copies) CASP_C PF08172.7 KOO30123.1 - 0.0039 16.2 5.3 0.006 15.6 3.7 1.3 1 0 0 1 1 1 1 CASP C terminal DndB PF14072.1 KOO30123.1 - 0.036 13.2 0.0 0.06 12.4 0.0 1.3 1 0 0 1 1 1 0 DNA-sulfur modification-associated FliH PF02108.11 KOO30123.1 - 0.15 11.9 7.8 0.084 12.7 3.8 1.8 2 0 0 2 2 2 0 Flagellar assembly protein FliH DUF342 PF03961.8 KOO30123.1 - 1.8 6.8 6.7 2.9 6.1 4.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) CDC37_N PF03234.9 KOO30123.1 - 2.5 8.3 7.4 11 6.3 5.1 2.0 1 1 0 1 1 1 0 Cdc37 N terminal kinase binding Ribosomal_S15 PF00312.17 KOO30125.1 - 3e-22 78.1 0.4 4.1e-22 77.7 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S15 Abhydrolase_6 PF12697.2 KOO30126.1 - 6.1e-16 58.9 9.9 6.1e-16 58.9 6.9 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO30126.1 - 0.019 14.6 5.9 0.14 11.8 4.1 2.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family TAT_signal PF10518.4 KOO30126.1 - 0.054 13.5 0.8 0.054 13.5 0.6 5.3 6 0 0 6 6 6 0 TAT (twin-arginine translocation) pathway signal sequence Exo_endo_phos PF03372.18 KOO30127.1 - 8e-13 48.8 0.0 9.5e-13 48.6 0.0 1.0 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 KOO30127.1 - 0.014 14.9 0.0 0.024 14.2 0.0 1.4 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase ShK PF01549.19 KOO30129.1 - 2.9e-26 91.5 44.7 1.4e-06 28.5 1.5 5.7 5 0 0 5 5 5 5 ShK domain-like 2OG-FeII_Oxy_3 PF13640.1 KOO30129.1 - 2.2e-09 37.7 0.1 9.5e-09 35.6 0.0 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO30129.1 - 7.3e-08 32.6 0.0 1.5e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-CCCH PF00642.19 KOO30129.1 - 0.033 13.8 6.3 32 4.3 0.0 4.6 4 0 0 4 4 4 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) BACK PF07707.10 KOO30130.1 - 1.5e-17 63.2 0.1 2.8e-17 62.4 0.0 1.5 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.26 KOO30130.1 - 5.1e-06 26.4 0.0 1.7e-05 24.7 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain Skp1 PF01466.14 KOO30130.1 - 0.0022 17.9 0.2 0.0056 16.6 0.1 1.6 1 0 0 1 1 1 1 Skp1 family, dimerisation domain RNA_pol_Rpb1_6 PF04992.9 KOO30132.1 - 0.0023 17.6 0.2 0.0027 17.4 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 DUF4618 PF15397.1 KOO30132.1 - 0.0098 15.2 9.7 0.012 14.9 6.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) WEMBL PF05701.6 KOO30132.1 - 0.013 13.9 17.4 0.037 12.4 12.1 1.6 1 1 0 1 1 1 0 Weak chloroplast movement under blue light ORC4_C PF14629.1 KOO30132.1 - 0.018 14.4 0.2 0.019 14.3 0.1 1.2 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 4 C-terminus Mer2 PF09074.5 KOO30132.1 - 0.02 14.8 4.9 0.051 13.5 3.4 1.7 1 1 0 1 1 1 0 Mer2 ATG16 PF08614.6 KOO30132.1 - 0.029 14.2 12.8 0.056 13.2 0.9 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) bZIP_1 PF00170.16 KOO30132.1 - 0.044 13.7 1.8 0.044 13.7 1.2 3.2 2 1 1 3 3 3 0 bZIP transcription factor IL11 PF07400.6 KOO30132.1 - 0.064 12.7 0.0 0.072 12.6 0.0 1.1 1 0 0 1 1 1 0 Interleukin 11 Thioredoxin PF00085.15 KOO30132.1 - 0.099 12.3 0.3 0.17 11.5 0.2 1.4 1 0 0 1 1 1 0 Thioredoxin TMPIT PF07851.8 KOO30132.1 - 0.17 10.9 2.0 0.25 10.3 1.4 1.1 1 0 0 1 1 1 0 TMPIT-like protein GAS PF13851.1 KOO30132.1 - 0.2 10.8 13.3 0.1 11.7 1.8 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Atg14 PF10186.4 KOO30132.1 - 0.2 10.5 9.6 0.27 10.1 6.7 1.3 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF641 PF04859.7 KOO30132.1 - 0.23 11.2 10.1 0.057 13.1 2.6 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DUF4201 PF13870.1 KOO30132.1 - 0.24 10.8 13.9 0.36 10.2 5.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) AAA_13 PF13166.1 KOO30132.1 - 0.32 9.3 6.4 0.35 9.2 4.5 1.1 1 0 0 1 1 1 0 AAA domain Seryl_tRNA_N PF02403.17 KOO30132.1 - 0.38 10.8 12.0 0.53 10.3 7.9 1.6 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain FliJ PF02050.11 KOO30132.1 - 0.62 10.1 15.3 0.94 9.5 5.4 2.3 2 0 0 2 2 2 0 Flagellar FliJ protein DUF2968 PF11180.3 KOO30132.1 - 0.95 8.8 17.9 0.082 12.2 7.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) DUF1664 PF07889.7 KOO30132.1 - 1.1 9.0 4.1 0.8 9.5 1.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ERM PF00769.14 KOO30132.1 - 1.5 8.3 16.7 2.1 7.8 11.6 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Prp19 PF08606.6 KOO30132.1 - 1.5 8.5 7.5 0.19 11.4 0.3 2.8 2 1 1 3 3 3 0 Prp19/Pso4-like TPR_MLP1_2 PF07926.7 KOO30132.1 - 1.8 8.3 17.2 0.45 10.2 7.5 2.4 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein TSC22 PF01166.13 KOO30132.1 - 1.9 8.5 10.8 1.6 8.7 1.0 3.2 2 1 0 3 3 3 0 TSC-22/dip/bun family APG6 PF04111.7 KOO30132.1 - 2.1 7.3 12.7 2.5 7.0 8.8 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Acyl-CoA_dh_C PF12806.2 KOO30132.1 - 2.1 8.1 6.8 0.28 11.0 1.7 2.0 2 1 0 2 2 1 0 Acetyl-CoA dehydrogenase C-terminal like PV-1 PF06637.6 KOO30132.1 - 2.5 6.5 10.5 3.7 6.0 7.3 1.4 1 1 0 1 1 1 0 PV-1 protein (PLVAP) DUF342 PF03961.8 KOO30132.1 - 2.7 6.3 6.5 3.3 6.0 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) FliT PF05400.8 KOO30132.1 - 2.9 8.3 14.6 0.57 10.6 6.1 2.5 2 1 0 2 2 2 0 Flagellar protein FliT WXG100 PF06013.7 KOO30132.1 - 3 7.9 6.4 1 9.4 1.4 2.3 1 1 1 2 2 2 0 Proteins of 100 residues with WXG Phage_lysis PF03245.8 KOO30132.1 - 3.3 7.7 13.3 57 3.7 8.1 2.5 1 1 0 1 1 1 0 Bacteriophage Rz lysis protein Zein-binding PF04576.10 KOO30132.1 - 3.3 7.8 14.5 3.9 7.6 1.4 2.6 1 1 2 3 3 3 0 Zein-binding Spc7 PF08317.6 KOO30132.1 - 4 5.9 11.5 5.5 5.5 7.9 1.2 1 1 0 1 1 1 0 Spc7 kinetochore protein Mnd1 PF03962.10 KOO30132.1 - 5.5 6.6 16.0 2.7 7.6 3.4 2.2 1 1 1 2 2 2 0 Mnd1 family FlaG PF03646.10 KOO30132.1 - 5.5 7.1 7.8 15 5.7 5.3 1.9 1 1 0 1 1 1 0 FlaG protein DUF972 PF06156.8 KOO30132.1 - 8 6.8 11.0 16 5.9 1.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF972) FA_hydroxylase PF04116.8 KOO30133.1 - 4.3e-09 36.7 10.1 6.3e-09 36.2 7.0 1.2 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily HAD_2 PF13419.1 KOO30133.1 - 0.54 10.4 5.0 17 5.6 0.3 3.0 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF4319 PF14203.1 KOO30133.1 - 0.97 9.0 11.6 0.51 9.9 0.3 4.0 3 1 1 4 4 4 0 Domain of unknown function (DUF4319) DASH_Dam1 PF08653.5 KOO30133.1 - 1.2 8.9 5.9 3.1 7.6 0.1 4.2 4 0 0 4 4 4 0 DASH complex subunit Dam1 cNMP_binding PF00027.24 KOO30134.1 - 5.5e-23 80.5 0.0 1.1e-13 50.7 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain HlyIII PF03006.15 KOO30135.1 - 5.5e-48 163.2 21.2 6.5e-48 163.0 14.7 1.1 1 0 0 1 1 1 1 Haemolysin-III related UAA PF08449.6 KOO30136.1 - 3.4e-56 190.3 4.9 3.9e-56 190.1 3.4 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 KOO30136.1 - 4.3e-06 26.7 18.1 0.0015 18.5 2.9 2.2 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.11 KOO30136.1 - 0.015 14.9 3.4 0.015 14.9 2.4 2.3 3 0 0 3 3 3 0 Triose-phosphate Transporter family UPF0546 PF10639.4 KOO30136.1 - 2 8.2 6.9 0.41 10.4 0.7 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0546 RabGAP-TBC PF00566.13 KOO30137.1 - 9.6e-18 64.4 0.0 1.3e-17 63.9 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Glyco_hydro_31 PF01055.21 KOO30138.1 - 2.3e-73 247.5 0.2 3.6e-73 246.8 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 ShK PF01549.19 KOO30138.1 - 0.00037 20.7 3.8 0.00078 19.7 2.6 1.5 1 0 0 1 1 1 1 ShK domain-like UCH PF00443.24 KOO30139.1 - 5.6e-54 183.0 0.0 7.8e-54 182.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOO30139.1 - 1.6e-24 86.8 0.0 2.2e-24 86.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Zn-ribbon_8 PF09723.5 KOO30139.1 - 0.23 11.4 1.8 0.93 9.5 0.2 2.3 2 0 0 2 2 2 0 Zinc ribbon domain IQ PF00612.22 KOO30142.1 - 4e-15 53.9 43.7 0.0015 17.9 0.1 7.2 7 0 0 7 7 7 6 IQ calmodulin-binding motif EF-hand_6 PF13405.1 KOO30142.1 - 3.1e-07 29.7 0.0 0.011 15.5 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO30142.1 - 3.1e-07 30.4 0.0 8.6e-07 29.0 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO30142.1 - 5.8e-07 28.3 0.0 0.01 15.1 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO30142.1 - 4.1e-05 22.7 1.1 0.053 12.8 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO30142.1 - 0.008 15.7 0.1 0.62 9.7 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain pair LMBR1 PF04791.11 KOO30142.1 - 0.55 8.7 3.4 0.85 8.1 2.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein FKBP_C PF00254.23 KOO30143.1 - 9.3e-19 67.2 0.0 1.3e-18 66.7 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.13 KOO30143.1 - 6.9e-10 39.0 0.5 1.5e-09 37.9 0.0 1.8 3 0 0 3 3 3 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase AAA_34 PF13872.1 KOO30144.1 - 3.7e-108 360.8 0.0 6.6e-108 360.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.1 KOO30144.1 - 3e-84 282.7 0.7 5.2e-73 245.8 1.3 2.6 2 0 0 2 2 2 2 Helicase_C-like Helicase_C PF00271.26 KOO30144.1 - 0.026 14.3 1.5 0.33 10.8 0.0 3.0 3 0 0 3 3 3 0 Helicase conserved C-terminal domain DEAD PF00270.24 KOO30144.1 - 0.039 13.4 0.0 0.1 12.0 0.0 1.7 1 0 0 1 1 1 0 DEAD/DEAH box helicase ResIII PF04851.10 KOO30144.1 - 0.058 13.2 0.0 0.17 11.7 0.0 1.8 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit RVT_2 PF07727.9 KOO30145.1 - 4.2e-25 88.1 0.0 6.8e-25 87.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.19 KOO30145.1 - 0.13 12.6 0.0 0.38 11.0 0.0 1.8 2 0 0 2 2 2 0 RNase H Lipase_GDSL_2 PF13472.1 KOO30146.1 - 4e-11 43.3 0.5 1e-10 42.0 0.1 1.9 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family SHS2_Rpb7-N PF03876.12 KOO30147.1 - 8.5e-13 48.2 0.0 1.5e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.18 KOO30147.1 - 1.1e-09 38.1 0.1 3.4e-09 36.6 0.0 1.8 1 1 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.7 KOO30147.1 - 0.0005 20.2 0.0 0.00077 19.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 PDDEXK_5 PF11645.3 KOO30147.1 - 0.083 12.5 0.1 0.18 11.5 0.1 1.5 1 1 0 1 1 1 0 PD-(D/E)XK endonuclease Ank_2 PF12796.2 KOO30148.1 - 2.9e-21 75.6 0.1 6.9e-15 55.1 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) DnaJ PF00226.26 KOO30148.1 - 7.3e-16 57.6 0.2 1.8e-15 56.3 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain Ank_4 PF13637.1 KOO30148.1 - 1.2e-12 47.9 0.1 1.8e-08 34.6 0.0 4.0 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO30148.1 - 6.7e-11 41.4 0.6 0.0016 18.1 0.0 4.3 3 1 1 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 KOO30148.1 - 1.3e-09 37.9 0.3 4.8e-06 26.6 0.0 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO30148.1 - 2.1e-09 36.7 0.2 0.099 12.9 0.0 4.9 4 1 1 5 5 5 2 Ankyrin repeat TPR_11 PF13414.1 KOO30148.1 - 8.3e-07 28.5 1.9 0.00051 19.6 0.1 3.0 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 KOO30148.1 - 3.8e-05 23.2 2.7 0.82 9.7 0.0 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO30148.1 - 0.0011 18.8 0.1 0.035 14.0 0.0 2.8 1 1 2 3 3 3 2 Tetratricopeptide repeat Filamin PF00630.14 KOO30149.1 - 1.2e-40 138.1 0.0 2.8e-11 43.8 0.0 7.2 7 0 0 7 7 7 6 Filamin/ABP280 repeat Multi_ubiq PF14452.1 KOO30149.1 - 0.022 14.7 0.0 2 8.4 0.0 2.6 2 0 0 2 2 2 0 Multiubiquitin Phycoerythr_ab PF02972.9 KOO30150.1 - 0.4 10.3 1.9 0.94 9.1 1.3 1.6 1 0 0 1 1 1 0 Phycoerythrin, alpha/beta chain Methyltransf_26 PF13659.1 KOO30151.1 - 0.00053 19.9 2.8 0.00083 19.3 1.5 1.5 1 1 0 1 1 1 1 Methyltransferase domain Ham1p_like PF01725.11 KOO30152.1 - 2.9e-46 157.2 0.0 4.3e-46 156.6 0.0 1.2 1 0 0 1 1 1 1 Ham1 family DUF2475 PF10629.4 KOO30154.1 - 6.8e-06 26.2 1.6 0.064 13.5 0.0 3.5 3 0 0 3 3 3 2 Protein of unknown function (DUF2475) IlvN PF07991.7 KOO30155.1 - 1.6e-58 196.6 0.3 4.1e-58 195.3 0.0 1.8 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, catalytic domain IlvC PF01450.14 KOO30155.1 - 2.7e-47 160.3 0.2 1.9e-29 102.4 0.0 2.2 2 0 0 2 2 2 2 Acetohydroxy acid isomeroreductase, catalytic domain 2-Hacid_dh_C PF02826.14 KOO30155.1 - 0.00024 20.3 0.0 0.00045 19.4 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.11 KOO30155.1 - 0.00053 19.4 0.0 0.00094 18.6 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA AdoHcyase_NAD PF00670.16 KOO30155.1 - 0.0051 16.6 0.1 0.011 15.6 0.1 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_7 PF13241.1 KOO30155.1 - 0.027 14.7 0.0 0.072 13.3 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding DUF4205 PF13898.1 KOO30156.1 - 1e-57 195.4 0.0 1.9e-54 184.7 0.0 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4205) Chloroa_b-bind PF00504.16 KOO30157.1 - 1.1e-27 97.2 0.0 1.8e-27 96.5 0.0 1.3 1 1 0 1 1 1 1 Chlorophyll A-B binding protein DUF3576 PF12100.3 KOO30157.1 - 0.034 14.2 0.0 0.055 13.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3576) HIG_1_N PF04588.8 KOO30158.1 - 1e-20 73.1 3.2 1.4e-20 72.7 2.2 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Pkinase PF00069.20 KOO30159.1 - 5.1e-15 55.3 0.0 1.9e-13 50.2 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO30159.1 - 4.2e-05 22.7 0.1 0.00026 20.1 0.0 1.9 1 1 1 2 2 2 1 Protein tyrosine kinase APH PF01636.18 KOO30159.1 - 0.0041 16.9 0.0 0.0041 16.9 0.0 2.2 2 1 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 KOO30159.1 - 0.059 12.1 0.0 0.081 11.7 0.0 1.0 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase TGS PF02824.16 KOO30160.1 - 2.9e-17 62.2 0.1 7.3e-17 60.9 0.0 1.7 2 0 0 2 2 2 1 TGS domain MMR_HSR1 PF01926.18 KOO30160.1 - 1.6e-15 57.1 0.0 2.8e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KOO30160.1 - 5.1e-07 29.0 0.0 4.1e-06 26.1 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.18 KOO30160.1 - 0.0022 17.8 0.1 0.22 11.3 0.0 2.3 1 1 0 2 2 2 1 Dynamin family ArgK PF03308.11 KOO30160.1 - 0.018 13.8 0.0 0.037 12.8 0.0 1.5 1 0 0 1 1 1 0 ArgK protein GTP_EFTU PF00009.22 KOO30160.1 - 0.037 13.4 0.2 30 3.9 0.0 3.7 2 2 1 3 3 3 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.1 KOO30160.1 - 0.16 11.9 0.0 0.37 10.7 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain FA_desaturase PF00487.19 KOO30161.1 - 3.2e-12 46.4 34.3 8e-11 41.8 17.0 2.5 2 1 0 2 2 2 2 Fatty acid desaturase DUF3329 PF11808.3 KOO30161.1 - 0.91 9.6 6.4 0.98 9.5 0.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3329) SSF PF00474.12 KOO30162.1 - 8.9e-15 54.2 30.5 8.9e-15 54.2 21.1 2.0 2 1 0 2 2 2 1 Sodium:solute symporter family Peptidase_M24 PF00557.19 KOO30163.1 - 2.9e-32 111.9 0.1 5.4e-32 111.0 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.13 KOO30163.1 - 2.3e-17 63.7 0.0 3.4e-15 56.7 0.0 2.5 2 1 0 2 2 2 2 Creatinase/Prolidase N-terminal domain DUF2984 PF11203.3 KOO30163.1 - 0.11 12.5 1.8 0.45 10.6 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2984) DUF968 PF06147.6 KOO30164.1 - 0.12 12.2 0.0 0.18 11.7 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF968) Peptidase_C2 PF00648.16 KOO30165.1 - 1.1e-28 100.0 0.9 1.1e-28 100.0 0.6 1.5 2 0 0 2 2 2 1 Calpain family cysteine protease WWE PF02825.15 KOO30165.1 - 5.3e-18 64.2 4.0 3.5e-09 35.9 0.0 3.0 3 0 0 3 3 3 2 WWE domain DSPc PF00782.15 KOO30167.1 - 5.4e-26 90.7 0.0 1.1e-25 89.6 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KOO30167.1 - 0.0015 17.9 0.0 0.0027 17.0 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 KOO30167.1 - 0.035 14.1 0.0 0.056 13.4 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate Pkinase PF00069.20 KOO30168.1 - 6.4e-09 35.3 0.0 9.6e-09 34.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO30168.1 - 5.2e-08 32.2 0.0 7.7e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PAP_fibrillin PF04755.7 KOO30170.1 - 6.4e-18 65.1 0.0 4.2e-16 59.2 0.0 2.2 1 1 0 1 1 1 1 PAP_fibrillin PP2C PF00481.16 KOO30171.1 - 6e-36 124.1 0.0 7.3e-36 123.8 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 KOO30171.1 - 0.0017 17.8 0.0 0.0022 17.4 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C RVT_2 PF07727.9 KOO30172.1 - 5.3e-30 104.1 0.0 8.3e-30 103.5 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KOO30172.1 - 6.8e-08 32.6 0.0 1.5e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain Macro PF01661.16 KOO30173.1 - 4.3e-23 81.4 0.0 5.2e-23 81.1 0.0 1.1 1 0 0 1 1 1 1 Macro domain PP2C PF00481.16 KOO30174.1 - 4.1e-45 154.1 0.0 7.1e-45 153.3 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOO30174.1 - 0.00023 20.9 0.8 0.69 9.5 0.0 2.9 3 0 0 3 3 3 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 KOO30174.1 - 0.001 18.5 0.9 0.001 18.5 0.6 3.0 2 1 0 2 2 2 1 Protein phosphatase 2C Peptidase_M35 PF02102.10 KOO30174.1 - 0.015 14.0 0.1 0.015 14.0 0.1 1.7 2 0 0 2 2 2 0 Deuterolysin metalloprotease (M35) family Filamin PF00630.14 KOO30175.1 - 7e-64 212.7 0.0 1.3e-15 57.7 0.0 6.5 6 0 0 6 6 6 6 Filamin/ABP280 repeat CAP_GLY PF01302.20 KOO30175.1 - 4.6e-18 64.6 1.7 9e-18 63.7 1.2 1.5 1 0 0 1 1 1 1 CAP-Gly domain Big_1 PF02369.11 KOO30175.1 - 3.9e-09 36.3 0.2 0.037 13.9 0.1 5.1 6 0 0 6 6 6 2 Bacterial Ig-like domain (group 1) Big_3_4 PF13754.1 KOO30175.1 - 0.019 15.3 5.4 9.5 6.6 0.3 6.0 7 0 0 7 7 7 0 Bacterial Ig-like domain (group 3) PapC_N PF13954.1 KOO30175.1 - 0.034 13.7 0.0 7.4 6.1 0.0 3.4 4 0 0 4 4 4 0 PapC N-terminal domain DUF4239 PF14023.1 KOO30176.1 - 3.9e-24 85.1 3.2 6.1e-24 84.5 2.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4239) Med20 PF08612.6 KOO30177.1 - 1.6e-11 43.8 0.0 2.1e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex HSP70 PF00012.15 KOO30178.1 - 5.4e-255 846.9 4.0 6.2e-255 846.7 2.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KOO30178.1 - 5e-16 58.2 0.4 2.4e-14 52.7 0.2 2.1 2 0 0 2 2 2 2 MreB/Mbl protein Hydantoinase_A PF01968.13 KOO30178.1 - 5.3e-05 22.4 1.6 0.13 11.2 0.1 3.3 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase FGGY_C PF02782.11 KOO30178.1 - 0.0021 17.7 0.1 0.018 14.6 0.0 2.4 2 1 1 3 3 3 1 FGGY family of carbohydrate kinases, C-terminal domain CDP-OH_P_transf PF01066.16 KOO30179.1 - 4.3e-14 52.6 9.9 4.3e-14 52.6 6.8 2.2 1 1 1 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF2644 PF10841.3 KOO30179.1 - 0.041 13.9 0.1 0.12 12.4 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2644) CAMSAP_CH PF11971.3 KOO30179.1 - 0.056 13.0 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 CAMSAP CH domain Pkinase PF00069.20 KOO30180.1 - 2.8e-43 147.9 0.0 5e-43 147.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO30180.1 - 1.7e-19 69.9 0.0 3.1e-19 69.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO30180.1 - 0.0028 16.7 0.1 0.0096 15.0 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 KOO30180.1 - 0.014 14.3 0.0 0.17 10.7 0.0 2.5 2 1 0 2 2 2 0 Kinase-like APH PF01636.18 KOO30180.1 - 4.8 6.8 11.9 1.1 8.9 1.6 3.5 2 2 0 2 2 2 0 Phosphotransferase enzyme family OmpA PF00691.15 KOO30181.1 - 4.5e-25 87.8 3.9 2.6e-16 59.7 0.0 3.4 3 0 0 3 3 3 2 OmpA family DUF2977 PF11192.3 KOO30183.1 - 0.91 9.4 5.9 2.7 7.8 0.5 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2977) Pkinase PF00069.20 KOO30184.1 - 1.7e-36 125.7 0.0 2.3e-36 125.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO30184.1 - 7.9e-21 74.2 0.0 1.1e-20 73.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO30184.1 - 0.00098 18.1 0.0 0.0015 17.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Aminotran_1_2 PF00155.16 KOO30185.1 - 9.6e-42 143.2 0.0 1.2e-41 142.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 KOO30185.1 - 0.00065 18.8 0.0 0.00089 18.3 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Neur_chan_memb PF02932.11 KOO30187.1 - 2e-05 24.6 0.5 3e-05 24.0 0.3 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF21 PF01595.15 KOO30187.1 - 0.14 11.3 0.8 5.5 6.2 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function DUF21 AP2 PF00847.15 KOO30190.1 - 1.3e-11 44.4 2.3 3.8e-05 23.7 0.0 3.6 3 0 0 3 3 3 2 AP2 domain Helicase_C PF00271.26 KOO30190.1 - 1.5e-10 40.7 0.4 5.2e-10 39.0 0.2 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOO30190.1 - 1.3e-09 37.8 0.1 2.6e-09 36.8 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase CedA PF10729.4 KOO30190.1 - 1.3e-05 24.6 0.0 0.12 11.9 0.0 3.0 2 0 0 2 2 2 2 Cell division activator CedA Patched PF02460.13 KOO30192.1 - 3.9e-10 38.3 21.0 0.00012 20.1 11.8 2.6 3 0 0 3 3 3 2 Patched family Dimer_Tnp_hAT PF05699.9 KOO30194.1 - 7.6e-17 60.7 0.2 3.6e-16 58.5 0.0 2.3 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region HTH_AsnC-type PF13404.1 KOO30196.1 - 0.017 14.6 1.1 5 6.7 0.0 3.2 3 0 0 3 3 3 0 AsnC-type helix-turn-helix domain FKBP_N PF01346.13 KOO30197.1 - 1.7e-08 34.5 0.0 4.1e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Tudor-knot PF11717.3 KOO30197.1 - 0.00017 21.2 0.1 0.00031 20.3 0.1 1.4 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain EF-hand_1 PF00036.27 KOO30198.1 - 7.9e-20 68.6 7.8 7.2e-06 24.9 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO30198.1 - 1.8e-18 64.7 3.4 4.8e-05 22.8 0.2 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO30198.1 - 2.2e-17 62.9 0.6 3.4e-08 33.5 0.2 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO30198.1 - 5.4e-16 57.1 8.3 0.00049 19.3 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO30198.1 - 3.2e-09 36.2 7.6 0.00026 20.5 0.0 3.9 3 1 1 4 4 4 2 EF-hand domain pair LRR_8 PF13855.1 KOO30198.1 - 7.3e-07 28.8 0.3 0.011 15.4 0.1 2.6 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.2 KOO30198.1 - 9.7e-06 25.0 1.4 0.048 13.2 0.0 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO30198.1 - 0.00058 19.5 1.0 4.7 7.6 0.1 4.6 3 1 1 4 4 4 1 Leucine Rich Repeat DUF4473 PF14747.1 KOO30198.1 - 0.046 13.9 0.7 0.15 12.3 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4473) LRR_7 PF13504.1 KOO30198.1 - 0.048 13.8 4.0 26 5.6 0.0 4.1 3 0 0 3 3 3 0 Leucine rich repeat VIT1 PF01988.14 KOO30199.1 - 8.1e-57 192.1 4.5 9.2e-57 191.9 3.1 1.0 1 0 0 1 1 1 1 VIT family EmrE PF13536.1 KOO30199.1 - 0.003 17.7 0.7 0.003 17.7 0.5 1.9 2 0 0 2 2 2 1 Multidrug resistance efflux transporter DUF1700 PF08006.6 KOO30199.1 - 0.14 11.4 1.2 0.25 10.6 0.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1700) Peptidase_U4 PF03419.8 KOO30199.1 - 0.73 8.8 3.2 1.1 8.2 2.3 1.2 1 0 0 1 1 1 0 Sporulation factor SpoIIGA GST_N PF02798.15 KOO30201.1 - 9.1e-10 38.5 0.0 1.8e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 KOO30201.1 - 5.9e-05 23.4 0.0 8.3e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain TPR_11 PF13414.1 KOO30202.1 - 5.5e-11 41.9 16.2 0.00039 20.0 2.9 3.3 3 0 0 3 3 3 3 TPR repeat TPR_16 PF13432.1 KOO30202.1 - 2.6e-08 34.2 23.5 2.8e-05 24.6 0.2 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO30202.1 - 0.0015 18.5 2.2 10 6.6 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO30202.1 - 0.0021 18.5 24.0 0.0033 17.9 0.1 5.1 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO30202.1 - 0.003 17.3 20.8 0.31 11.0 0.8 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.1 KOO30202.1 - 0.025 14.4 2.2 0.025 14.4 1.6 2.7 1 1 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOO30202.1 - 0.15 11.7 15.3 2 8.1 0.1 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.1 KOO30202.1 - 3.2 8.1 16.4 0.36 11.2 0.2 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat DUF2630 PF10944.3 KOO30205.1 - 3.5 7.8 15.2 0.61 10.2 0.1 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2630) B PF02216.11 KOO30206.1 - 0.14 11.9 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 B domain Glyco_transf_34 PF05637.7 KOO30207.1 - 0.00025 20.6 0.0 0.63 9.5 0.0 2.2 2 0 0 2 2 2 2 galactosyl transferase GMA12/MNN10 family Nucleotid_trans PF03407.11 KOO30207.1 - 0.015 15.1 0.0 0.027 14.2 0.0 1.5 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase CreA PF05981.7 KOO30208.1 - 3.7e-25 87.9 0.1 4.7e-25 87.5 0.1 1.2 1 0 0 1 1 1 1 CreA protein DUF4476 PF14771.1 KOO30208.1 - 0.056 13.4 0.2 0.63 10.1 0.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4476) Sema PF01403.14 KOO30208.1 - 0.07 11.6 0.0 0.087 11.3 0.0 1.1 1 0 0 1 1 1 0 Sema domain Peptidase_S10 PF00450.17 KOO30209.1 - 3.7e-78 263.5 0.7 5e-78 263.1 0.5 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase Cyclin_N PF00134.18 KOO30210.1 - 5.2e-08 32.4 0.1 8.8e-08 31.7 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Spy1 PF11357.3 KOO30210.1 - 0.022 14.8 0.0 0.038 14.0 0.0 1.3 1 0 0 1 1 1 0 Cell cycle regulatory protein FMO-like PF00743.14 KOO30211.1 - 4.1e-44 150.6 1.0 7.1e-16 57.4 0.0 5.0 4 1 0 4 4 4 4 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 KOO30211.1 - 1.2e-19 71.1 0.0 1.4e-15 57.8 0.0 3.2 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 KOO30211.1 - 2.8e-11 42.9 1.0 1e-05 24.6 0.0 4.1 3 1 1 4 4 4 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 KOO30211.1 - 2.5e-10 40.2 1.4 1.6e-09 37.6 0.1 2.9 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 KOO30211.1 - 6.2e-10 39.2 3.4 3.5e-06 27.0 2.4 3.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 KOO30211.1 - 2.8e-07 29.7 1.3 3.3e-06 26.2 0.0 2.9 3 0 0 3 3 3 1 FAD dependent oxidoreductase Amino_oxidase PF01593.19 KOO30211.1 - 5.8e-06 25.6 0.1 4.4e-05 22.7 0.0 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.19 KOO30211.1 - 6.6e-06 25.2 0.4 1.9e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.12 KOO30211.1 - 6.6e-06 25.3 2.4 7.5e-05 21.9 0.7 2.4 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.22 KOO30211.1 - 7.8e-06 26.2 2.0 0.00017 21.8 0.3 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 KOO30211.1 - 2.5e-05 23.4 0.6 0.00012 21.2 0.2 2.0 2 0 0 2 2 2 1 FAD binding domain Shikimate_DH PF01488.15 KOO30211.1 - 4.2e-05 23.6 0.4 0.091 12.8 0.1 2.4 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase FAD_oxidored PF12831.2 KOO30211.1 - 7.1e-05 22.0 1.2 0.00012 21.3 0.8 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.1 KOO30211.1 - 9.9e-05 22.5 0.0 0.09 13.0 0.0 2.5 2 0 0 2 2 2 1 Putative NAD(P)-binding NAD_binding_9 PF13454.1 KOO30211.1 - 0.00016 21.4 1.6 0.13 12.0 0.1 4.2 4 1 0 4 4 3 1 FAD-NAD(P)-binding HI0933_like PF03486.9 KOO30211.1 - 0.00028 19.4 2.2 0.00031 19.3 0.2 1.9 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.17 KOO30211.1 - 0.0065 15.3 4.5 0.13 11.0 0.6 2.8 3 0 0 3 3 3 1 Glucose inhibited division protein A TrkA_N PF02254.13 KOO30211.1 - 0.0088 16.0 1.2 0.39 10.7 0.1 2.5 2 0 0 2 2 2 1 TrkA-N domain 2-Hacid_dh_C PF02826.14 KOO30211.1 - 0.017 14.2 0.1 3.3 6.8 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ThiF PF00899.16 KOO30211.1 - 0.025 14.3 2.2 0.57 10.0 0.2 2.5 2 0 0 2 2 2 0 ThiF family IlvN PF07991.7 KOO30211.1 - 0.037 13.3 0.3 0.49 9.7 0.1 2.5 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain AlaDh_PNT_C PF01262.16 KOO30211.1 - 0.041 13.4 0.4 0.087 12.3 0.3 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.13 KOO30211.1 - 0.073 12.7 1.5 0.12 11.9 0.2 1.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Trp_halogenase PF04820.9 KOO30211.1 - 0.088 11.4 1.2 0.33 9.5 0.6 2.0 2 0 0 2 2 2 0 Tryptophan halogenase CPSase_L_chain PF00289.17 KOO30211.1 - 0.094 12.8 0.1 7.8 6.6 0.0 2.4 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, N-terminal domain ApbA PF02558.11 KOO30211.1 - 0.12 11.8 0.4 0.27 10.6 0.3 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Lycopene_cycl PF05834.7 KOO30211.1 - 0.16 10.8 1.8 4.9 5.9 0.1 2.6 3 0 0 3 3 3 0 Lycopene cyclase protein Skp1_POZ PF03931.10 KOO30212.1 - 2.8e-15 56.1 0.0 5.6e-15 55.1 0.0 1.5 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain BTB PF00651.26 KOO30212.1 - 0.00014 21.8 0.0 0.00019 21.4 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Gly_transf_sug PF04488.10 KOO30213.1 - 1.9e-07 31.4 0.0 3.5e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 KOO30213.1 - 7.2e-06 24.7 0.2 0.076 11.4 0.0 2.1 2 0 0 2 2 2 2 TcdA/TcdB catalytic glycosyltransferase domain CAP_GLY PF01302.20 KOO30216.1 - 5.4e-16 58.0 0.1 8.2e-16 57.4 0.1 1.3 1 0 0 1 1 1 1 CAP-Gly domain Arm PF00514.18 KOO30217.1 - 0.0053 16.5 0.0 0.0098 15.6 0.0 1.6 1 0 0 1 1 1 1 Armadillo/beta-catenin-like repeat Arm PF00514.18 KOO30219.1 - 8.5e-46 152.2 57.6 2.9e-06 26.8 0.1 22.9 24 0 0 24 24 24 11 Armadillo/beta-catenin-like repeat V-ATPase_H_N PF03224.9 KOO30219.1 - 0.0053 15.9 1.7 7.2 5.6 0.0 4.7 3 2 0 3 3 3 2 V-ATPase subunit H Arm_2 PF04826.8 KOO30219.1 - 0.007 15.4 1.1 0.16 11.0 0.0 3.5 4 0 0 4 4 4 1 Armadillo-like Atx10homo_assoc PF09759.4 KOO30219.1 - 0.0083 15.8 6.9 1.9 8.2 0.0 5.9 6 1 1 7 7 7 1 Spinocerebellar ataxia type 10 protein domain V-ATPase_H_C PF11698.3 KOO30219.1 - 0.011 15.6 0.2 0.12 12.3 0.0 3.0 3 1 1 4 4 4 0 V-ATPase subunit H TATR PF03430.8 KOO30219.1 - 0.63 8.6 4.2 0.95 8.0 2.9 1.1 1 0 0 1 1 1 0 Trans-activating transcriptional regulator IQ PF00612.22 KOO30220.1 - 1.5e-08 33.4 31.6 0.14 11.9 0.1 8.7 9 0 0 9 9 9 6 IQ calmodulin-binding motif Arm PF00514.18 KOO30221.1 - 2.5e-15 55.6 21.7 0.048 13.4 0.0 10.4 9 2 1 10 10 10 7 Armadillo/beta-catenin-like repeat Arm PF00514.18 KOO30222.1 - 5e-19 67.3 3.8 0.00048 19.8 0.0 4.3 4 0 0 4 4 4 4 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO30222.1 - 0.00013 22.1 10.9 0.0024 18.1 2.3 2.3 1 1 1 2 2 2 2 HEAT repeats WAPL PF07814.8 KOO30222.1 - 0.00023 20.0 0.2 0.0015 17.3 0.1 2.0 1 1 0 2 2 2 1 Wings apart-like protein regulation of heterochromatin V-ATPase_H_N PF03224.9 KOO30222.1 - 0.0061 15.7 0.0 0.0088 15.1 0.0 1.2 1 0 0 1 1 1 1 V-ATPase subunit H RasGEF_N_2 PF14663.1 KOO30222.1 - 0.0085 16.0 0.2 1.7 8.6 0.0 2.2 2 0 0 2 2 2 2 Rapamycin-insensitive companion of mTOR RasGEF_N domain HEAT_EZ PF13513.1 KOO30222.1 - 0.015 15.7 4.6 2.2 8.9 0.2 3.5 3 0 0 3 3 3 0 HEAT-like repeat LRR_6 PF13516.1 KOO30223.1 - 7.6e-10 37.8 0.1 0.00012 21.8 0.0 3.3 3 0 0 3 3 3 2 Leucine Rich repeat LRR_4 PF12799.2 KOO30223.1 - 6.9e-07 28.7 0.0 0.00023 20.7 0.0 2.2 1 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO30223.1 - 7.9e-05 22.2 0.1 2.7 8.5 0.0 3.5 3 0 0 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 KOO30223.1 - 0.00043 19.9 0.0 1.8 8.9 0.0 3.2 3 0 0 3 3 3 1 Leucine Rich Repeat LRR_8 PF13855.1 KOO30223.1 - 0.093 12.5 0.4 4.7 7.0 0.3 2.7 1 1 0 1 1 1 0 Leucine rich repeat DUF1336 PF07059.7 KOO30224.1 - 1.1e-31 109.9 0.0 1.4e-31 109.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1336) DUF572 PF04502.8 KOO30225.1 - 1.8e-70 237.7 7.5 1.9e-70 237.6 5.2 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) zf-FCS PF06467.9 KOO30225.1 - 0.095 12.3 0.5 4.2 7.0 0.0 2.3 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif RNA_pol_N PF01194.12 KOO30225.1 - 0.48 10.4 0.1 0.48 10.4 0.1 2.9 2 1 0 2 2 2 0 RNA polymerases N / 8 kDa subunit DNA_primase_lrg PF04104.9 KOO30226.1 - 5.6 6.1 6.2 3.9 6.6 1.5 2.8 2 0 0 2 2 2 0 Eukaryotic and archaeal DNA primase, large subunit zf-C3HC4_4 PF15227.1 KOO30227.1 - 3.8e-08 33.0 12.3 6.3e-08 32.3 8.5 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Rad60-SLD PF11976.3 KOO30227.1 - 8.5e-07 28.5 0.0 1.5e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zf-C3HC4_3 PF13920.1 KOO30227.1 - 1.7e-06 27.5 8.8 3e-06 26.7 6.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO30227.1 - 2.8e-06 26.8 11.4 4.7e-06 26.1 7.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO30227.1 - 9.4e-06 25.5 12.7 1.6e-05 24.7 8.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO30227.1 - 1.1e-05 25.1 13.9 2e-05 24.3 9.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 KOO30227.1 - 1.6e-05 24.4 12.4 2.8e-05 23.7 8.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 KOO30227.1 - 0.00027 20.5 8.4 0.00047 19.8 5.8 1.4 1 0 0 1 1 1 1 RING-type zinc-finger U-box PF04564.10 KOO30227.1 - 0.0029 17.5 0.0 0.0081 16.0 0.0 1.7 2 0 0 2 2 2 1 U-box domain zf-RING_4 PF14570.1 KOO30227.1 - 0.0055 16.2 2.2 0.012 15.2 1.5 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.1 KOO30227.1 - 0.17 11.6 3.1 0.34 10.7 2.2 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein DZR PF12773.2 KOO30227.1 - 1.2 9.0 7.2 3.5 7.5 5.2 1.7 1 1 0 1 1 1 0 Double zinc ribbon GRP PF07172.6 KOO30228.1 - 0.11 12.9 30.0 0.47 10.9 4.4 2.8 2 0 0 2 2 2 0 Glycine rich protein family DUF2763 PF10961.3 KOO30228.1 - 5.6 7.4 22.7 0.037 14.4 2.6 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2763) Ala_racemase_N PF01168.15 KOO30230.1 - 2.4e-42 144.9 0.0 2.7e-42 144.7 0.0 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Mg_trans_NIPA PF05653.9 KOO30231.1 - 1.4e-16 60.3 9.7 2.5e-09 36.5 0.3 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EmrE PF13536.1 KOO30231.1 - 0.0027 17.9 2.6 0.0027 17.9 1.8 3.6 3 1 1 4 4 4 2 Multidrug resistance efflux transporter EamA PF00892.15 KOO30231.1 - 0.044 13.8 22.3 0.037 14.0 1.5 3.7 2 2 2 4 4 4 0 EamA-like transporter family Glyco_transf_22 PF03901.12 KOO30232.1 - 1.3e-24 86.9 0.5 1.8e-24 86.5 0.3 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family SET PF00856.23 KOO30232.1 - 0.0023 18.2 0.1 0.0058 16.9 0.0 1.8 2 1 0 2 2 2 1 SET domain F5_F8_type_C PF00754.20 KOO30236.1 - 0.00017 21.4 0.0 0.00022 21.0 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain Glyco_transf_22 PF03901.12 KOO30239.1 - 3.9e-53 180.9 3.5 4.7e-53 180.6 2.4 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family DUF563 PF04577.9 KOO30240.1 - 4e-06 26.8 0.0 6.1e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) PPR_2 PF13041.1 KOO30241.1 - 1.8e-63 210.3 0.0 8.9e-09 35.1 0.0 11.5 2 2 10 12 12 12 11 PPR repeat family PPR_3 PF13812.1 KOO30241.1 - 6.1e-56 182.0 16.3 7.8e-07 28.8 0.0 13.7 13 0 0 13 13 13 11 Pentatricopeptide repeat domain PPR PF01535.15 KOO30241.1 - 2.8e-45 149.1 9.4 0.00015 21.5 0.0 13.3 13 0 0 13 13 13 10 PPR repeat PPR_1 PF12854.2 KOO30241.1 - 1.5e-32 110.7 3.0 5.3e-05 22.6 0.0 9.5 11 0 0 11 11 11 7 PPR repeat SAP PF02037.22 KOO30241.1 - 8.8e-08 31.4 0.4 8.8e-08 31.4 0.3 1.8 2 0 0 2 2 2 1 SAP domain ECSIT PF06239.6 KOO30241.1 - 1.8e-05 23.7 0.2 4.1 6.2 0.0 5.9 4 2 2 6 6 6 1 Evolutionarily conserved signalling intermediate in Toll pathway Ank_2 PF12796.2 KOO30241.1 - 0.0036 17.5 0.2 0.55 10.6 0.0 3.1 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) LETM1 PF07766.8 KOO30241.1 - 0.0097 14.9 0.2 0.018 14.1 0.1 1.3 1 0 0 1 1 1 1 LETM1-like protein RICTOR_V PF14668.1 KOO30241.1 - 0.029 14.3 0.1 0.34 10.8 0.0 2.3 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 NETI PF14044.1 KOO30241.1 - 0.057 12.9 0.0 13 5.3 0.0 3.5 3 0 0 3 3 3 0 NETI protein Radical_SAM PF04055.16 KOO30241.1 - 0.088 12.9 0.0 1.9 8.6 0.0 2.7 3 0 0 3 3 3 0 Radical SAM superfamily Aldedh PF00171.17 KOO30242.1 - 1.9e-151 504.5 0.2 2.3e-151 504.2 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Aldo_ket_red PF00248.16 KOO30243.1 - 5e-44 150.2 0.0 7.3e-44 149.6 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family SRCR PF00530.13 KOO30243.1 - 1.3e-16 60.7 0.5 1.3e-16 60.7 0.3 2.3 2 0 0 2 2 2 1 Scavenger receptor cysteine-rich domain FYDLN_acid PF09538.5 KOO30243.1 - 2.9 8.5 17.3 5.3 7.6 12.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Mito_fiss_reg PF05308.6 KOO30244.1 - 1.2 8.4 2.9 2 7.7 2.0 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator DnaJ_CXXCXGXG PF00684.14 KOO30245.1 - 0.002 18.1 5.3 0.0038 17.2 3.7 1.5 1 0 0 1 1 1 1 DnaJ central domain PhyH PF05721.8 KOO30246.1 - 0.00063 19.8 0.0 0.00084 19.4 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) NYN_YacP PF05991.6 KOO30247.1 - 3.4e-29 101.7 0.1 5.6e-29 101.0 0.0 1.4 1 0 0 1 1 1 1 YacP-like NYN domain DEAD_assoc PF08494.6 KOO30247.1 - 0.15 11.7 2.1 1.7 8.3 0.9 2.2 1 1 1 2 2 2 0 DEAD/H associated RNA_pol_Rpb4 PF03874.11 KOO30248.1 - 8.4e-19 67.7 0.3 1.1e-18 67.3 0.2 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 Drf_GBD PF06371.8 KOO30249.1 - 4.3e-07 29.4 0.0 1.1e-06 28.1 0.0 1.6 1 1 0 1 1 1 1 Diaphanous GTPase-binding Domain PH PF00169.24 KOO30249.1 - 2.7e-06 27.5 0.0 4.8e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 PH domain Drf_FH3 PF06367.11 KOO30249.1 - 9.8e-05 21.8 0.0 0.00017 21.0 0.0 1.3 1 0 0 1 1 1 1 Diaphanous FH3 Domain PH_11 PF15413.1 KOO30249.1 - 0.089 13.0 0.2 0.32 11.2 0.1 2.0 1 1 0 1 1 1 0 Pleckstrin homology domain LRR_6 PF13516.1 KOO30252.1 - 2.3e-21 73.4 0.8 0.0014 18.5 0.0 5.1 4 0 0 4 4 4 4 Leucine Rich repeat Skp1 PF01466.14 KOO30252.1 - 0.0069 16.3 0.0 0.022 14.7 0.0 1.9 1 0 0 1 1 1 1 Skp1 family, dimerisation domain SpoU_sub_bind PF08032.7 KOO30252.1 - 0.0099 16.0 1.6 2.5 8.3 0.1 3.3 2 2 1 3 3 3 2 RNA 2'-O ribose methyltransferase substrate binding LRR_4 PF12799.2 KOO30252.1 - 0.011 15.3 1.5 0.15 11.6 0.1 2.9 1 1 2 3 3 3 0 Leucine Rich repeats (2 copies) HeH PF12949.2 KOO30253.1 - 2.3e-05 23.8 0.1 8.2e-05 22.0 0.1 1.8 2 0 0 2 2 2 1 HeH/LEM domain EF-hand_7 PF13499.1 KOO30253.1 - 0.012 15.7 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair HAD_2 PF13419.1 KOO30253.1 - 0.015 15.5 0.0 0.038 14.2 0.0 1.6 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Rho_N PF07498.7 KOO30253.1 - 0.076 12.7 1.1 0.22 11.3 0.4 2.1 2 0 0 2 2 2 0 Rho termination factor, N-terminal domain Methyltransf_16 PF10294.4 KOO30254.1 - 0.039 13.3 0.0 0.041 13.3 0.0 1.0 1 0 0 1 1 1 0 Putative methyltransferase NTP_transf_2 PF01909.18 KOO30255.1 - 6.3e-10 39.2 0.0 8e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyltransferase domain Tubulin PF00091.20 KOO30256.1 - 7.3e-35 120.7 0.0 8e-35 120.6 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Cons_hypoth698 PF03601.9 KOO30257.1 - 5.4e-62 209.1 16.4 7.2e-62 208.7 11.4 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 698 PC-Esterase PF13839.1 KOO30257.1 - 0.2 11.4 0.0 0.95 9.2 0.0 1.9 1 1 0 1 1 1 0 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p TniQ PF06527.6 KOO30258.1 - 0.14 12.3 0.3 0.14 12.3 0.2 1.0 1 0 0 1 1 1 0 TniQ Keratin PF02422.11 KOO30259.1 - 0.14 12.1 0.3 0.14 12.1 0.2 1.8 2 0 0 2 2 2 0 Keratin OCD_Mu_crystall PF02423.10 KOO30260.1 - 3.6e-44 150.8 0.4 5e-44 150.3 0.3 1.3 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.15 KOO30260.1 - 0.0047 17.0 0.0 0.0082 16.2 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Filamin PF00630.14 KOO30261.1 - 3.2e-06 27.6 0.0 0.16 12.5 0.0 3.4 3 1 0 3 3 3 3 Filamin/ABP280 repeat zf-RING_2 PF13639.1 KOO30262.1 - 2.6e-12 46.3 6.2 4.7e-12 45.5 4.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KOO30262.1 - 3.2e-09 36.7 1.2 6.9e-09 35.6 0.8 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 KOO30262.1 - 3.4e-06 26.6 5.1 6e-06 25.8 3.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO30262.1 - 1.3e-05 24.8 7.2 2.2e-05 24.0 5.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 KOO30262.1 - 5.3e-05 23.1 5.3 9.8e-05 22.3 3.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO30262.1 - 0.0002 20.9 7.6 0.00031 20.3 5.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 KOO30262.1 - 0.12 12.2 6.8 1.1 9.1 4.6 2.2 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.24 KOO30262.1 - 0.65 9.7 7.5 1.2 8.9 4.9 1.6 1 1 0 1 1 1 0 PHD-finger RINGv PF12906.2 KOO30262.1 - 1.1 9.3 9.4 2.1 8.4 6.5 1.5 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.3 KOO30262.1 - 4.5 7.3 9.1 6 6.9 5.0 2.1 1 1 1 2 2 2 0 FANCL C-terminal domain ESSS PF10183.4 KOO30263.1 - 7.2e-13 48.8 0.1 1.5e-12 47.7 0.1 1.5 2 0 0 2 2 2 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) ABM PF03992.11 KOO30263.1 - 0.073 13.1 0.2 0.5 10.4 0.0 2.3 2 1 0 2 2 2 0 Antibiotic biosynthesis monooxygenase MIG-14_Wnt-bd PF06664.7 KOO30264.1 - 2.9e-20 72.3 0.5 4.7e-20 71.6 0.4 1.3 1 0 0 1 1 1 1 Wnt-binding factor required for Wnt secretion PP2C PF00481.16 KOO30265.1 - 3.5e-47 160.9 0.5 4.6e-46 157.2 0.4 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C FAD_binding_4 PF01565.18 KOO30266.1 - 1.3e-15 57.0 0.4 2.1e-15 56.4 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain ALO PF04030.9 KOO30266.1 - 1.4e-14 54.2 0.0 2.6e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase Ribosomal_L10 PF00466.15 KOO30267.1 - 2e-13 50.1 0.0 2.9e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 Syntaxin-6_N PF09177.6 KOO30268.1 - 0.018 15.4 0.8 0.018 15.4 0.5 2.6 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Lzipper-MIP1 PF14389.1 KOO30268.1 - 0.018 15.1 6.1 0.042 13.9 0.5 2.6 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Nup54 PF13874.1 KOO30268.1 - 0.47 10.1 12.6 1.8 8.2 1.8 2.9 1 1 1 3 3 3 0 Nucleoporin complex subunit 54 APG6 PF04111.7 KOO30268.1 - 3.3 6.6 21.4 2.1 7.3 0.9 2.2 1 1 1 2 2 2 0 Autophagy protein Apg6 Defensin_propep PF00879.13 KOO30268.1 - 4 7.4 10.8 4.3 7.3 2.8 2.8 3 0 0 3 3 3 0 Defensin propeptide Ank_2 PF12796.2 KOO30269.1 - 5.5e-11 42.6 0.3 1e-10 41.8 0.2 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO30269.1 - 6.8e-11 42.0 0.3 1.6e-10 40.8 0.2 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.25 KOO30269.1 - 4e-10 38.9 1.6 1e-09 37.6 0.1 2.3 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.1 KOO30269.1 - 3.6e-09 36.8 0.2 6.9e-09 35.9 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO30269.1 - 4.4e-06 26.4 0.3 1.3e-05 24.9 0.1 1.9 2 0 0 2 2 2 1 Ankyrin repeat AP2 PF00847.15 KOO30270.1 - 0.00022 21.2 0.2 0.00022 21.2 0.2 2.1 2 0 0 2 2 2 1 AP2 domain HTH_19 PF12844.2 KOO30270.1 - 0.028 14.4 0.0 0.061 13.3 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_3 PF01381.17 KOO30270.1 - 0.04 13.7 0.0 0.14 12.0 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix HTH_23 PF13384.1 KOO30270.1 - 0.056 13.1 0.0 0.19 11.4 0.0 1.9 1 0 0 1 1 1 0 Homeodomain-like domain EF-hand_1 PF00036.27 KOO30273.1 - 2.3e-13 48.3 4.8 9.6e-07 27.6 0.1 4.3 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO30273.1 - 3e-13 49.1 0.7 7.4e-05 22.2 0.2 3.7 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO30273.1 - 5.7e-09 35.1 1.6 0.004 16.9 0.0 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.1 KOO30273.1 - 1.2e-08 34.9 0.3 0.0007 19.6 0.2 3.4 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO30273.1 - 2.3e-07 29.8 6.5 0.0039 16.4 0.1 3.4 3 0 0 3 3 3 2 EF hand EF-hand_4 PF12763.2 KOO30273.1 - 9.1e-05 22.1 0.3 0.65 9.7 0.0 3.1 3 0 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand Sel1 PF08238.7 KOO30274.1 - 7.5e-18 64.5 5.0 5.2e-07 30.0 1.2 3.7 3 0 0 3 3 3 3 Sel1 repeat U-box PF04564.10 KOO30274.1 - 4.1e-10 39.4 0.0 7.6e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO30274.1 - 0.00032 20.1 0.1 0.0011 18.3 0.0 1.9 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit DJ-1_PfpI PF01965.19 KOO30274.1 - 0.13 11.7 0.2 0.31 10.4 0.1 1.7 2 0 0 2 2 2 0 DJ-1/PfpI family ADK PF00406.17 KOO30275.1 - 2.5e-72 241.7 0.0 2.5e-39 134.5 0.0 2.8 3 0 0 3 3 3 2 Adenylate kinase AAA_17 PF13207.1 KOO30275.1 - 2.6e-17 63.7 0.5 2.8e-08 34.5 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_33 PF13671.1 KOO30275.1 - 1.9e-12 47.2 0.0 9.5e-06 25.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 KOO30275.1 - 1.8e-11 44.4 0.0 0.00032 20.9 0.0 2.8 2 1 0 2 2 2 2 AAA domain EF-hand_7 PF13499.1 KOO30275.1 - 2.8e-10 40.1 0.0 8.8e-10 38.5 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO30275.1 - 9e-08 30.8 5.5 0.00057 19.0 0.0 3.3 3 0 0 3 3 3 2 EF hand 5_nucleotid_C PF02872.13 KOO30275.1 - 9.9e-08 32.1 0.0 2.3e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Thymidylate_kin PF02223.12 KOO30275.1 - 1.7e-07 30.7 4.9 0.015 14.7 0.1 3.5 3 0 0 3 3 3 2 Thymidylate kinase EF-hand_5 PF13202.1 KOO30275.1 - 4.6e-07 28.8 2.6 0.0043 16.3 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO30275.1 - 5.2e-07 29.0 0.3 0.043 13.7 0.0 3.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO30275.1 - 8.6e-05 22.0 0.3 0.0037 16.8 0.0 2.8 2 0 0 2 2 2 1 EF-hand domain pair SRP54 PF00448.17 KOO30275.1 - 0.0004 19.8 0.4 0.49 9.8 0.0 2.5 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain AAA_19 PF13245.1 KOO30275.1 - 0.00065 19.3 2.8 0.14 11.9 0.1 2.9 3 0 0 3 3 2 2 Part of AAA domain AAA PF00004.24 KOO30275.1 - 0.0029 17.7 0.3 5.7 7.1 0.0 3.6 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO30275.1 - 0.0081 16.1 0.0 1.9 8.4 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain Zeta_toxin PF06414.7 KOO30275.1 - 0.14 11.2 0.5 17 4.4 0.1 2.5 2 0 0 2 2 2 0 Zeta toxin PYRIN PF02758.11 KOO30276.1 - 0.026 14.2 0.1 0.054 13.1 0.0 1.5 1 0 0 1 1 1 0 PAAD/DAPIN/Pyrin domain SBDS_C PF09377.5 KOO30276.1 - 0.055 13.1 0.6 0.089 12.4 0.2 1.6 2 0 0 2 2 2 0 SBDS protein C-terminal domain PEP-utilisers_N PF05524.8 KOO30276.1 - 1.6 8.5 5.0 0.38 10.5 1.0 1.6 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal zf-C2H2_4 PF13894.1 KOO30277.1 - 0.43 11.0 2.8 0.87 10.0 2.0 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger NPV_P10 PF05531.7 KOO30279.1 - 2.2 8.5 8.0 1 9.6 1.0 3.4 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein 2OG-FeII_Oxy_4 PF13661.1 KOO30280.1 - 5.8e-13 48.2 0.1 1.1e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.1 KOO30280.1 - 3.4e-09 37.1 0.0 5.7e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Dus PF01207.12 KOO30281.1 - 7.7e-42 143.1 2.5 8e-42 143.1 0.0 1.9 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) Peptidase_M10 PF00413.19 KOO30281.1 - 8.2e-05 22.3 0.0 0.0006 19.5 0.0 2.4 2 1 0 2 2 2 1 Matrixin Peptidase_M57 PF12388.3 KOO30281.1 - 0.011 15.0 0.1 0.031 13.6 0.1 1.7 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Astacin PF01400.19 KOO30281.1 - 0.68 9.2 3.8 0.35 10.2 0.7 1.8 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) PPR_2 PF13041.1 KOO30282.1 - 5.7e-41 138.2 0.0 8.2e-06 25.7 0.0 10.5 10 1 2 12 12 12 6 PPR repeat family PPR PF01535.15 KOO30282.1 - 6.3e-33 110.4 1.6 0.0026 17.6 0.0 13.3 13 0 0 13 13 13 5 PPR repeat PPR_3 PF13812.1 KOO30282.1 - 8.2e-30 100.5 39.5 0.0023 18.0 0.0 14.6 15 0 0 15 15 15 7 Pentatricopeptide repeat domain BNR_2 PF13088.1 KOO30282.1 - 1.7e-18 66.9 0.0 4.4e-18 65.5 0.0 1.7 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.15 KOO30282.1 - 2.3e-06 26.5 7.2 0.41 10.6 0.1 4.0 3 0 0 3 3 3 3 BNR/Asp-box repeat PPR_1 PF12854.2 KOO30282.1 - 5.6e-06 25.7 2.3 0.53 9.8 0.0 6.1 6 0 0 6 6 6 2 PPR repeat Apc3 PF12895.2 KOO30282.1 - 0.0017 18.4 6.1 0.025 14.6 0.0 4.7 5 1 1 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 MgsA_C PF12002.3 KOO30282.1 - 0.013 15.2 2.9 0.045 13.4 0.3 3.0 2 0 0 2 2 2 0 MgsA AAA+ ATPase C terminal CesT PF05932.8 KOO30282.1 - 0.022 14.6 0.1 0.071 12.9 0.1 1.9 1 0 0 1 1 1 0 Tir chaperone protein (CesT) family TPR_19 PF14559.1 KOO30282.1 - 0.035 14.4 20.7 0.42 10.9 0.1 6.8 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO30282.1 - 0.92 10.3 57.5 1.5 9.6 0.3 12.9 8 4 6 14 14 14 0 Tetratricopeptide repeat EF-hand_1 PF00036.27 KOO30283.1 - 2.7e-07 29.4 0.0 0.043 13.1 0.0 3.5 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.1 KOO30283.1 - 2.8e-07 29.5 0.2 0.0033 16.7 0.0 3.6 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO30283.1 - 1.7e-06 27.4 0.3 0.1 12.5 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO30283.1 - 0.0012 18.9 0.3 2.6 8.2 0.1 2.8 1 1 0 2 2 2 2 EF-hand domain pair IQ PF00612.22 KOO30283.1 - 0.019 14.5 0.2 0.053 13.1 0.2 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif EF-hand_8 PF13833.1 KOO30283.1 - 0.019 14.5 0.2 7.1 6.3 0.0 3.3 3 1 0 3 3 3 0 EF-hand domain pair zf-RING_2 PF13639.1 KOO30286.1 - 6.1e-07 29.1 9.9 1.3e-06 28.1 6.9 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KOO30286.1 - 3.6e-06 26.9 5.5 6.3e-06 26.2 3.8 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger FANCL_C PF11793.3 KOO30286.1 - 9.6e-06 25.4 6.9 2.5e-05 24.1 4.8 1.7 1 1 0 1 1 1 1 FANCL C-terminal domain zf-Apc11 PF12861.2 KOO30286.1 - 0.0021 17.8 6.5 0.0049 16.6 4.5 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.2 KOO30286.1 - 0.0038 17.2 7.9 0.0096 15.9 5.5 1.8 1 1 0 1 1 1 1 RING-variant domain zf-C3HC4 PF00097.20 KOO30286.1 - 0.016 14.8 10.6 0.036 13.7 7.3 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.6 KOO30286.1 - 0.024 14.6 3.6 0.024 14.6 2.5 2.2 3 0 0 3 3 3 0 RING-like domain SIR2 PF02146.12 KOO30286.1 - 0.15 11.7 0.3 0.23 11.1 0.2 1.3 1 0 0 1 1 1 0 Sir2 family zf-C3HC4_2 PF13923.1 KOO30286.1 - 0.2 11.6 10.5 1.3 9.1 7.8 2.0 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) C1_1 PF00130.17 KOO30286.1 - 0.42 10.3 9.7 0.076 12.7 3.2 2.3 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.24 KOO30286.1 - 0.49 10.1 7.9 0.94 9.2 5.5 1.5 1 0 0 1 1 1 0 PHD-finger IBR PF01485.16 KOO30286.1 - 0.84 9.5 8.2 3.4 7.6 5.7 1.8 1 1 0 1 1 1 0 IBR domain zf-C3HC4_3 PF13920.1 KOO30286.1 - 0.97 9.1 8.9 12 5.7 6.5 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) GAGA PF09237.6 KOO30286.1 - 1.4 8.5 6.9 6.1 6.5 0.3 2.4 1 1 1 2 2 2 0 GAGA factor zf-RING_5 PF14634.1 KOO30286.1 - 9.7 6.0 11.2 30 4.4 7.8 1.9 1 1 1 2 2 2 0 zinc-RING finger domain Laminin_II PF06009.7 KOO30287.1 - 0.00032 20.4 1.0 0.00068 19.3 0.7 1.6 1 1 0 1 1 1 1 Laminin Domain II DUF2721 PF11026.3 KOO30287.1 - 3 7.4 6.9 0.55 9.8 1.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Ion_trans PF00520.26 KOO30288.1 - 4.9e-69 231.5 36.3 5.3e-32 110.6 7.1 3.4 3 0 0 3 3 3 3 Ion transport protein EF-hand_1 PF00036.27 KOO30288.1 - 0.00012 21.1 0.0 0.0012 18.0 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.1 KOO30288.1 - 0.00033 19.8 0.0 0.00079 18.6 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO30288.1 - 0.0013 18.8 0.0 0.0028 17.7 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO30288.1 - 0.12 12.2 0.0 0.34 10.9 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain PDZ_2 PF13180.1 KOO30289.1 - 7.3e-05 22.5 0.3 0.00014 21.6 0.2 1.5 1 1 0 1 1 1 1 PDZ domain PDZ PF00595.19 KOO30289.1 - 9.4e-05 22.5 0.0 0.00017 21.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Glyco_transf_34 PF05637.7 KOO30290.1 - 0.079 12.4 0.2 0.15 11.5 0.1 1.3 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family EF-hand_1 PF00036.27 KOO30292.1 - 9.9e-20 68.2 11.2 3.9e-05 22.6 0.6 5.3 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.1 KOO30292.1 - 6.2e-19 67.9 3.8 7.2e-10 38.8 0.1 4.1 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO30292.1 - 8.8e-16 56.3 12.0 0.00021 20.8 0.4 5.5 5 0 0 5 5 5 3 EF-hand domain EF-hand_8 PF13833.1 KOO30292.1 - 8.8e-14 50.8 9.9 2.3e-05 23.9 0.4 4.9 5 0 0 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO30292.1 - 6.8e-11 40.9 13.3 0.00051 19.2 0.0 4.9 4 0 0 4 4 4 3 EF hand GSCFA PF08885.6 KOO30292.1 - 0.00054 19.5 0.0 0.0011 18.6 0.0 1.5 1 0 0 1 1 1 1 GSCFA family EF-hand_10 PF14788.1 KOO30292.1 - 0.053 13.2 0.8 8.9 6.0 0.0 3.3 3 0 0 3 3 3 0 EF hand DUF3486 PF11985.3 KOO30292.1 - 3.2 7.7 8.8 0.25 11.3 2.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3486) PIP5K PF01504.13 KOO30293.1 - 1.1e-54 185.2 0.0 1.6e-54 184.6 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Siah-Interact_N PF09032.6 KOO30293.1 - 0.0048 16.9 0.3 0.0096 15.9 0.2 1.5 1 0 0 1 1 1 1 Siah interacting protein, N terminal Git3 PF11710.3 KOO30293.1 - 0.035 13.6 0.5 0.072 12.6 0.3 1.4 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 HMG_box PF00505.14 KOO30297.1 - 2.4e-07 30.8 0.7 2.4e-07 30.8 0.5 3.2 2 2 0 2 2 2 1 HMG (high mobility group) box SHIPPO-rpt PF07004.7 KOO30298.1 - 2.5e-11 43.8 19.4 0.045 14.6 0.1 7.1 7 0 0 7 7 7 4 Sperm-tail PG-rich repeat Fasciclin PF02469.17 KOO30299.1 - 1.5e-63 212.5 0.5 6.7e-31 106.9 0.0 2.1 2 0 0 2 2 2 2 Fasciclin domain tRNA_anti_2 PF13742.1 KOO30299.1 - 0.012 15.4 0.2 5.5 6.9 0.0 2.3 2 0 0 2 2 2 0 OB-fold nucleic acid binding domain Peptidase_M73 PF12389.3 KOO30299.1 - 0.032 13.7 0.3 1.4 8.3 0.1 2.1 2 0 0 2 2 2 0 Camelysin metallo-endopeptidase DUF4339 PF14237.1 KOO30299.1 - 0.033 13.7 0.0 13 5.4 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4339) EutN_CcmL PF03319.8 KOO30299.1 - 0.04 14.3 0.1 15 6.0 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation protein EutN/carboxysome CSD PF00313.17 KOO30300.1 - 2.5e-12 46.3 0.0 4e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain zf-CCCH PF00642.19 KOO30300.1 - 0.00057 19.5 0.2 0.00057 19.5 0.1 1.9 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) OB_RNB PF08206.6 KOO30300.1 - 0.025 14.0 0.1 0.055 12.9 0.1 1.6 1 0 0 1 1 1 0 Ribonuclease B OB domain JmjC PF02373.17 KOO30301.1 - 9.8e-34 116.0 0.1 1.7e-33 115.2 0.0 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.12 KOO30301.1 - 2.1e-09 36.7 0.2 4.3e-09 35.7 0.2 1.6 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.11 KOO30301.1 - 5.5 7.1 5.4 0.75 9.9 0.2 2.1 2 0 0 2 2 2 0 C5HC2 zinc finger NDK PF00334.14 KOO30302.1 - 2.7e-22 79.0 0.0 9.7e-22 77.2 0.0 1.8 2 0 0 2 2 2 1 Nucleoside diphosphate kinase G3P_antiterm PF04309.7 KOO30302.1 - 0.17 10.9 0.0 0.53 9.3 0.0 1.7 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator VCBS PF13517.1 KOO30303.1 - 1e-20 73.8 2.3 2.1e-13 50.4 0.1 2.8 1 1 1 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO30303.1 - 1.8e-14 52.9 10.6 8.6e-05 22.1 0.1 3.9 3 0 0 3 3 3 3 FG-GAP repeat Ank_2 PF12796.2 KOO30303.1 - 9e-07 29.1 0.1 0.014 15.6 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO30303.1 - 1.5e-06 28.2 0.3 0.073 13.3 0.2 3.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO30303.1 - 9.5e-05 22.0 5.5 0.37 10.6 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.1 KOO30303.1 - 0.0045 17.1 0.9 1.9 8.9 0.0 3.8 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.1 KOO30303.1 - 0.0056 17.1 0.2 3.1 8.4 0.2 3.1 3 0 0 3 3 3 1 Ankyrin repeats (many copies) BBS2_Mid PF14783.1 KOO30303.1 - 0.024 14.3 0.0 3.1 7.5 0.0 3.1 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region TcdB_toxin_midN PF12256.3 KOO30303.1 - 0.037 13.4 0.3 5.3 6.4 0.0 2.6 2 0 0 2 2 2 0 Insecticide toxin TcdB middle/N-terminal region EF-hand_5 PF13202.1 KOO30303.1 - 2 7.9 4.3 8.3 5.9 0.1 2.5 2 0 0 2 2 2 0 EF hand Mito_carr PF00153.22 KOO30305.1 - 1.7e-34 117.4 9.5 1.2e-14 53.7 0.1 4.0 3 1 0 3 3 3 3 Mitochondrial carrier protein Ldr_toxin PF13940.1 KOO30305.1 - 3.9 7.3 6.1 3 7.6 1.1 2.5 2 0 0 2 2 2 0 Toxin Ldr, type I toxin-antitoxin system Metallophos PF00149.23 KOO30306.1 - 1.4e-16 60.4 0.1 3.3e-16 59.2 0.1 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.1 KOO30306.1 - 1.5e-13 50.6 0.0 3.8e-13 49.2 0.0 1.7 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Metallophos_2 PF12850.2 KOO30306.1 - 0.0011 18.8 0.0 0.0023 17.7 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain TauE PF01925.14 KOO30306.1 - 0.031 13.7 0.2 0.053 12.9 0.2 1.3 1 0 0 1 1 1 0 Sulfite exporter TauE/SafE PBP1_TM PF14812.1 KOO30307.1 - 0.23 11.7 1.9 0.29 11.4 1.3 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RNA_pol_3_Rpc31 PF11705.3 KOO30307.1 - 2 8.2 6.4 2.5 7.9 4.4 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 UQ_con PF00179.21 KOO30308.1 - 9.8e-15 54.2 0.0 6.3e-14 51.5 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KOO30308.1 - 0.0011 18.7 0.0 0.0016 18.1 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B Prok-E2_A PF14457.1 KOO30308.1 - 0.0014 18.0 0.1 0.0026 17.2 0.1 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family A LAT PF15234.1 KOO30308.1 - 0.18 11.2 4.4 0.3 10.5 2.9 1.4 1 1 0 1 1 1 0 Linker for activation of T-cells DUF2457 PF10446.4 KOO30308.1 - 0.22 10.2 5.6 0.25 10.0 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PBP1_TM PF14812.1 KOO30308.1 - 0.48 10.7 6.6 0.8 10.0 4.6 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Myc_N PF01056.13 KOO30308.1 - 0.57 9.2 5.1 0.78 8.8 3.5 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Daxx PF03344.10 KOO30308.1 - 0.64 8.4 5.5 0.75 8.2 3.8 1.1 1 0 0 1 1 1 0 Daxx Family Nop14 PF04147.7 KOO30308.1 - 0.67 7.8 4.5 0.76 7.6 3.1 1.1 1 0 0 1 1 1 0 Nop14-like family Nucleoplasmin PF03066.10 KOO30308.1 - 1.7 8.1 9.8 2.8 7.4 6.8 1.3 1 0 0 1 1 1 0 Nucleoplasmin Sigma70_ner PF04546.8 KOO30308.1 - 3.7 7.1 8.5 0.26 10.8 2.7 1.5 2 0 0 2 2 2 0 Sigma-70, non-essential region NOA36 PF06524.7 KOO30308.1 - 8 5.6 7.6 11 5.1 5.3 1.1 1 0 0 1 1 1 0 NOA36 protein E1-E2_ATPase PF00122.15 KOO30309.1 - 7.5e-50 169.0 2.9 7.5e-50 169.0 2.0 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 KOO30309.1 - 5e-24 85.9 0.0 2.1e-23 83.8 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO30309.1 - 1.1e-15 58.2 0.0 2.4e-15 57.1 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 KOO30309.1 - 1.9e-09 36.8 0.0 4.6e-09 35.6 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 KOO30309.1 - 0.00013 21.6 0.5 0.0012 18.5 0.2 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOO30309.1 - 0.00075 19.4 0.0 0.0017 18.2 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit PsbI PF02532.9 KOO30309.1 - 0.17 11.5 1.6 0.54 9.9 1.1 1.9 1 0 0 1 1 1 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) Phage_int_SAM_1 PF02899.12 KOO30311.1 - 0.31 11.2 3.0 0.62 10.2 2.0 1.6 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Methyltransf_15 PF09445.5 KOO30313.1 - 7.3e-44 149.2 0.0 9.3e-44 148.8 0.0 1.1 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_26 PF13659.1 KOO30313.1 - 2e-10 40.7 0.2 3.8e-10 39.8 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Gemin7 PF11095.3 KOO30313.1 - 6.7e-07 28.9 0.0 1.6e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 Gem-associated protein 7 (Gemin7) Methyltransf_18 PF12847.2 KOO30313.1 - 8.8e-07 29.4 0.0 1.4e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 KOO30313.1 - 1.1e-05 25.0 0.0 2.8e-05 23.8 0.0 1.3 1 1 0 1 1 1 1 Met-10+ like-protein UPF0020 PF01170.13 KOO30313.1 - 1.6e-05 24.5 0.0 2.4e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Cons_hypoth95 PF03602.10 KOO30313.1 - 0.0016 17.8 0.0 0.0023 17.3 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 RrnaAD PF00398.15 KOO30313.1 - 0.0026 16.8 0.0 0.0034 16.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase MTS PF05175.9 KOO30313.1 - 0.0029 17.0 0.0 0.004 16.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain CoA_binding_2 PF13380.1 KOO30313.1 - 0.049 13.7 0.0 0.084 13.0 0.0 1.5 1 0 0 1 1 1 0 CoA binding domain IF3_C PF00707.17 KOO30315.1 - 3.8e-09 36.1 0.0 5.8e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.11 KOO30315.1 - 4.1e-07 29.8 0.2 1e-06 28.5 0.1 1.7 2 0 0 2 2 2 1 Translation initiation factor IF-3, N-terminal domain GTP_EFTU PF00009.22 KOO30316.1 - 2.9e-57 193.1 0.0 4.6e-57 192.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 KOO30316.1 - 3.7e-36 123.3 0.0 7.6e-36 122.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.1 KOO30316.1 - 4.4e-29 100.1 0.0 1e-28 98.9 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.19 KOO30316.1 - 7.5e-23 80.2 0.1 2.1e-22 78.8 0.1 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 KOO30316.1 - 9e-11 41.7 0.0 2.2e-10 40.4 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 KOO30316.1 - 0.00086 19.2 0.0 0.0021 18.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.11 KOO30316.1 - 0.0052 15.9 0.0 0.01 14.9 0.0 1.4 1 0 0 1 1 1 1 AIG1 family DUF442 PF04273.8 KOO30316.1 - 0.063 13.1 0.0 25 4.7 0.0 3.5 3 0 0 3 3 3 0 Putative phosphatase (DUF442) Miro PF08477.8 KOO30316.1 - 0.094 13.2 0.0 0.22 12.0 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein Amidohydro_2 PF04909.9 KOO30317.1 - 1.2e-26 93.8 1.0 1.7e-26 93.4 0.7 1.2 1 0 0 1 1 1 1 Amidohydrolase IQ PF00612.22 KOO30318.1 - 2.9e-05 23.3 57.4 0.55 10.0 0.0 12.4 13 0 0 13 13 13 7 IQ calmodulin-binding motif UBA PF00627.26 KOO30318.1 - 0.00012 21.7 0.1 0.17 11.7 0.0 3.2 2 0 0 2 2 2 2 UBA/TS-N domain UBA_4 PF14555.1 KOO30318.1 - 0.087 12.3 0.2 3.5 7.2 0.0 2.7 2 0 0 2 2 2 0 UBA-like domain GST_N PF02798.15 KOO30319.1 - 8.2e-09 35.5 0.0 1.6e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 KOO30319.1 - 0.00016 21.8 0.0 0.0004 20.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 KOO30319.1 - 0.0012 18.8 0.0 0.0022 17.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KOO30319.1 - 0.0024 17.7 0.3 0.0072 16.1 0.2 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 KOO30319.1 - 0.003 17.9 0.0 0.0053 17.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain p31comet PF06581.7 KOO30319.1 - 0.11 11.4 0.0 3.3 6.5 0.0 2.2 2 0 0 2 2 2 0 Mad1 and Cdc20-bound-Mad2 binding HC2 PF07382.6 KOO30320.1 - 0.017 14.9 18.5 0.018 14.9 12.8 1.0 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 HC2 PF07382.6 KOO30321.1 - 0.0096 15.7 14.2 0.0096 15.7 9.9 1.0 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 DUF4573 PF15140.1 KOO30323.1 - 0.06 12.9 0.6 0.076 12.6 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4573) 6PF2K PF01591.13 KOO30325.1 - 7.8e-37 126.5 0.1 1.4e-36 125.7 0.1 1.5 1 1 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 KOO30325.1 - 3.3e-33 115.0 0.1 7.1e-33 113.9 0.0 1.6 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) DUF2414 PF10309.4 KOO30326.1 - 8.2e-17 60.6 0.0 1.4e-16 59.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2414) SPT6_acidic PF14632.1 KOO30326.1 - 0.0027 17.8 1.9 0.0052 16.9 1.3 1.4 1 0 0 1 1 1 1 Acidic N-terminal SPT6 Ribosomal_S10 PF00338.17 KOO30327.1 - 1.6e-14 53.5 0.1 2.8e-14 52.7 0.0 1.4 2 0 0 2 2 2 1 Ribosomal protein S10p/S20e DLIC PF05783.6 KOO30329.1 - 2.1e-11 43.1 0.0 3.4e-09 35.8 0.0 2.1 1 1 0 1 1 1 1 Dynein light intermediate chain (DLIC) Miro PF08477.8 KOO30329.1 - 1.6e-06 28.6 0.3 1e-05 25.9 0.0 2.4 3 0 0 3 3 3 1 Miro-like protein Ras PF00071.17 KOO30329.1 - 4.9e-05 22.7 0.0 0.00022 20.6 0.0 1.9 1 1 0 2 2 2 1 Ras family Dynamin_N PF00350.18 KOO30329.1 - 0.00043 20.1 0.1 0.0015 18.4 0.0 1.8 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.18 KOO30329.1 - 0.00076 19.4 0.0 0.0015 18.4 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.1 KOO30329.1 - 0.0011 18.9 0.9 0.0082 16.1 0.1 2.2 2 1 0 2 2 2 1 AAA ATPase domain GTP_EFTU PF00009.22 KOO30329.1 - 0.0061 16.0 0.0 0.78 9.1 0.0 2.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Septin PF00735.13 KOO30329.1 - 0.0069 15.4 0.0 0.013 14.5 0.0 1.4 1 0 0 1 1 1 1 Septin Arf PF00025.16 KOO30329.1 - 0.011 15.0 0.0 0.2 10.8 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family Plasmid_stab_B PF10784.4 KOO30329.1 - 0.014 15.0 0.3 0.031 13.9 0.2 1.5 1 0 0 1 1 1 0 Plasmid stability protein AAA_29 PF13555.1 KOO30329.1 - 0.023 14.2 0.0 0.06 12.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF1515 PF07439.6 KOO30329.1 - 0.087 12.6 0.4 0.19 11.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) ATP_bind_1 PF03029.12 KOO30329.1 - 0.1 12.1 0.0 3.3 7.2 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein G-alpha PF00503.15 KOO30329.1 - 0.11 11.1 0.5 0.79 8.3 0.0 2.2 2 1 0 3 3 3 0 G-protein alpha subunit tRNA-synt_1g PF09334.6 KOO30330.1 - 2.3e-119 398.5 0.0 2.4e-118 395.2 0.0 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (M) PPR_2 PF13041.1 KOO30330.1 - 7e-79 259.6 0.0 1.5e-13 50.4 0.0 13.1 4 3 9 13 13 13 11 PPR repeat family PPR_3 PF13812.1 KOO30330.1 - 3.4e-62 201.5 24.3 6.4e-06 26.0 0.0 15.5 14 0 0 14 14 14 11 Pentatricopeptide repeat domain PPR PF01535.15 KOO30330.1 - 3.1e-57 186.6 0.6 9e-06 25.3 0.0 12.7 13 0 0 13 13 13 10 PPR repeat PPR_1 PF12854.2 KOO30330.1 - 4.1e-56 186.1 4.8 1.1e-08 34.4 0.0 11.0 11 0 0 11 11 11 8 PPR repeat tRNA-synt_1 PF00133.17 KOO30330.1 - 1.6e-30 105.6 0.0 6.3e-14 50.8 0.0 4.0 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.14 KOO30330.1 - 2.3e-12 46.6 0.0 1.5e-05 24.3 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain ECSIT PF06239.6 KOO30330.1 - 0.033 13.0 0.0 7 5.4 0.0 3.8 4 1 1 5 5 5 0 Evolutionarily conserved signalling intermediate in Toll pathway Anticodon_1 PF08264.8 KOO30330.1 - 0.046 13.4 0.0 0.15 11.8 0.0 1.9 2 0 0 2 2 2 0 Anticodon-binding domain of tRNA DUF4003 PF13170.1 KOO30330.1 - 0.098 11.8 0.0 0.75 8.9 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4003) tRNA-synt_1f PF01921.13 KOO30330.1 - 0.19 10.3 0.0 1.8 7.1 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (K) Enolase_C PF00113.17 KOO30331.1 - 8.4e-131 435.3 0.0 1.1e-130 434.9 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.11 KOO30331.1 - 1e-52 177.5 0.4 1.7e-52 176.8 0.3 1.3 1 0 0 1 1 1 1 Enolase, N-terminal domain MAAL_C PF07476.6 KOO30331.1 - 6.8e-06 25.2 0.7 6.8e-06 25.2 0.5 1.8 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus MR_MLE_C PF13378.1 KOO30331.1 - 0.009 15.9 0.0 0.03 14.3 0.0 1.8 2 0 0 2 2 2 1 Enolase C-terminal domain-like ADIP PF11559.3 KOO30333.1 - 0.0069 16.2 5.2 0.0069 16.2 3.6 4.5 2 2 2 5 5 5 1 Afadin- and alpha -actinin-Binding AsnA PF03590.10 KOO30333.1 - 0.031 13.7 0.1 1.7 7.9 0.0 2.4 2 0 0 2 2 2 0 Aspartate-ammonia ligase TruB_C PF09142.6 KOO30333.1 - 0.16 11.6 3.6 2.3 7.9 0.1 3.1 3 0 0 3 3 3 0 tRNA Pseudouridine synthase II, C terminal PUF PF00806.14 KOO30335.1 - 4.5e-17 60.4 0.0 0.0034 16.7 0.0 6.2 7 0 0 7 7 7 5 Pumilio-family RNA binding repeat EF-hand_1 PF00036.27 KOO30336.1 - 2.6e-14 51.3 1.5 0.0019 17.3 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 KOO30336.1 - 3.3e-13 48.3 2.2 0.00092 18.9 0.0 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.1 KOO30336.1 - 6.3e-12 45.4 0.1 9.8e-07 28.8 0.3 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO30336.1 - 1.3e-09 37.5 0.9 1e-06 28.2 0.3 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO30336.1 - 3.5e-07 29.2 11.0 0.042 13.1 0.2 3.7 4 0 0 4 4 4 3 EF hand EF-hand_10 PF14788.1 KOO30336.1 - 0.016 14.8 1.8 16 5.2 0.1 4.1 4 1 1 5 5 5 0 EF hand EF-hand_4 PF12763.2 KOO30336.1 - 0.14 11.9 1.1 63 3.3 0.0 3.2 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand LCM PF04072.9 KOO30337.1 - 6.8e-23 81.1 0.0 9.8e-23 80.6 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase GARS_A PF01071.14 KOO30338.1 - 5.1e-45 153.4 0.0 8.1e-45 152.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Formyl_trans_N PF00551.14 KOO30338.1 - 4.3e-40 137.1 0.0 6e-40 136.7 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase GARS_C PF02843.11 KOO30338.1 - 5.8e-16 58.4 0.0 1.5e-15 57.1 0.0 1.7 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain ATP-grasp_4 PF13535.1 KOO30338.1 - 1.3e-06 28.2 0.0 8.2e-06 25.6 0.0 2.1 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_2 PF08442.5 KOO30338.1 - 0.023 14.0 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain PNMA PF14893.1 KOO30338.1 - 0.11 11.5 0.0 0.22 10.4 0.0 1.4 2 0 0 2 2 2 0 PNMA FGE-sulfatase PF03781.11 KOO30339.1 - 6.2e-27 94.5 0.2 1.3e-26 93.5 0.1 1.5 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 DUF4303 PF14136.1 KOO30341.1 - 0.0088 15.7 7.2 0.0088 15.7 5.0 2.1 2 1 0 2 2 2 1 Domain of unknown function (DUF4303) Peripla_BP_2 PF01497.13 KOO30341.1 - 0.078 12.0 3.0 1 8.4 0.0 2.4 2 0 0 2 2 2 0 Periplasmic binding protein Tic22 PF04278.7 KOO30342.1 - 4.9e-16 58.8 0.0 9.6e-16 57.8 0.0 1.4 1 1 0 1 1 1 1 Tic22-like family IQ PF00612.22 KOO30343.1 - 6.4e-07 28.4 0.3 0.017 14.6 0.1 2.6 2 0 0 2 2 2 2 IQ calmodulin-binding motif DUF3275 PF11679.3 KOO30343.1 - 6 6.4 6.3 11 5.5 4.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) AA_kinase PF00696.23 KOO30344.1 - 0.00076 19.0 1.1 0.00093 18.7 0.8 1.1 1 0 0 1 1 1 1 Amino acid kinase family DUF4407 PF14362.1 KOO30344.1 - 0.0085 15.0 8.8 0.011 14.7 6.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) TMF_DNA_bd PF12329.3 KOO30344.1 - 0.012 15.3 1.9 0.012 15.3 1.3 4.0 1 1 3 4 4 4 0 TATA element modulatory factor 1 DNA binding Ded_cyto PF06920.8 KOO30344.1 - 0.013 14.7 4.0 0.023 13.9 2.6 1.6 1 1 1 2 2 2 0 Dedicator of cytokinesis TBPIP PF07106.8 KOO30344.1 - 0.077 12.5 10.8 0.53 9.8 2.6 2.6 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) FUSC PF04632.7 KOO30344.1 - 0.17 10.3 8.5 0.21 9.9 5.9 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Prefoldin_2 PF01920.15 KOO30344.1 - 0.31 10.8 12.9 0.49 10.1 0.9 3.4 2 1 0 3 3 3 0 Prefoldin subunit Reo_sigmaC PF04582.7 KOO30344.1 - 0.32 10.1 3.8 0.47 9.5 0.3 1.8 1 1 1 2 2 2 0 Reovirus sigma C capsid protein NRDE-2 PF08424.5 KOO30344.1 - 0.33 9.7 4.9 0.55 9.0 3.4 1.3 1 0 0 1 1 1 0 NRDE-2, necessary for RNA interference TMCO5 PF14992.1 KOO30344.1 - 0.96 8.5 12.3 0.73 8.9 7.5 1.3 1 1 0 1 1 1 0 TMCO5 family Fib_alpha PF08702.5 KOO30344.1 - 2.8 8.0 6.6 1.6 8.8 2.9 1.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Lebercilin PF15619.1 KOO30344.1 - 3.3 7.0 19.9 15 4.9 0.5 2.2 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease FlxA PF14282.1 KOO30344.1 - 3.9 7.4 8.4 25 4.8 0.2 3.2 1 1 2 3 3 3 0 FlxA-like protein MxiH PF09392.5 KOO30344.1 - 4.1 8.0 5.8 1.9e+02 2.7 4.0 2.6 1 1 0 1 1 1 0 Type III secretion needle MxiH like TIG PF01833.19 KOO30345.1 - 4e-66 219.0 5.5 3e-08 33.5 0.0 12.8 11 3 0 11 11 11 10 IPT/TIG domain Peptidase_M24 PF00557.19 KOO30346.1 - 7.9e-43 146.4 0.0 1.7e-42 145.3 0.0 1.6 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.13 KOO30346.1 - 3.1e-26 92.3 0.0 1.9e-22 80.1 0.0 2.6 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain TIG PF01833.19 KOO30347.1 - 4.1e-73 241.4 15.4 1.4e-09 37.8 0.0 17.5 18 1 0 18 18 18 14 IPT/TIG domain MORN PF02493.15 KOO30348.1 - 8.3e-82 264.3 90.1 2.7e-06 26.7 1.7 15.6 16 0 0 16 16 16 14 MORN repeat Ion_trans PF00520.26 KOO30348.1 - 5.6e-21 74.7 7.7 7.6e-21 74.2 5.3 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO30348.1 - 1.6e-12 46.9 7.8 3.7e-12 45.7 5.4 1.6 1 0 0 1 1 1 1 Ion channel NQRA_SLBB PF11973.3 KOO30348.1 - 0.0013 19.0 0.0 4.2 7.7 0.0 4.4 4 0 0 4 4 4 1 NQRA C-terminal domain EF-hand_1 PF00036.27 KOO30348.1 - 0.0059 15.8 0.1 0.014 14.6 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 KOO30348.1 - 0.015 14.8 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair SecD_SecF PF02355.11 KOO30348.1 - 0.025 13.7 1.6 0.045 12.9 1.1 1.4 1 0 0 1 1 1 0 Protein export membrane protein EF-hand_5 PF13202.1 KOO30348.1 - 0.034 13.4 0.4 0.034 13.4 0.2 2.2 2 0 0 2 2 2 0 EF hand EF-hand_7 PF13499.1 KOO30348.1 - 0.035 14.2 0.0 0.073 13.2 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair FLILHELTA PF10306.4 KOO30348.1 - 0.22 11.5 0.1 0.49 10.4 0.1 1.5 1 0 0 1 1 1 0 Hypothetical protein FLILHELTA PKD_channel PF08016.7 KOO30348.1 - 0.33 9.3 4.9 0.24 9.7 0.8 2.0 1 1 1 2 2 2 0 Polycystin cation channel BTB PF00651.26 KOO30349.1 - 8.1e-10 38.6 0.0 8e-08 32.2 0.0 2.3 1 1 1 2 2 2 1 BTB/POZ domain Kelch_5 PF13854.1 KOO30349.1 - 1.6e-07 31.1 0.0 0.01 15.7 0.0 2.9 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.1 KOO30349.1 - 3.3e-06 27.1 1.3 0.1 12.8 0.0 4.1 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_4 PF13418.1 KOO30349.1 - 7.9e-05 22.3 5.2 0.0026 17.4 0.0 3.5 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.1 KOO30349.1 - 0.0002 21.3 2.7 0.088 13.0 0.0 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.20 KOO30349.1 - 0.023 14.2 0.0 0.95 9.0 0.0 2.7 3 0 0 3 3 3 0 Kelch motif Asp23 PF03780.8 KOO30351.1 - 0.015 15.5 0.0 0.051 13.8 0.0 1.9 1 0 0 1 1 1 0 Asp23 family DUF212 PF02681.9 KOO30351.1 - 0.026 14.2 3.2 0.049 13.3 2.2 1.4 1 0 0 1 1 1 0 Divergent PAP2 family PDZ_2 PF13180.1 KOO30351.1 - 0.027 14.3 0.0 0.066 13.1 0.0 1.6 1 0 0 1 1 1 0 PDZ domain Ribosomal_L14e PF01929.12 KOO30352.1 - 0.023 15.0 0.1 0.057 13.7 0.1 1.6 1 0 0 1 1 1 0 Ribosomal protein L14 MobA_MobL PF03389.10 KOO30353.1 - 0.081 12.3 0.1 0.12 11.7 0.1 1.4 1 0 0 1 1 1 0 MobA/MobL family Shufflon_N PF04917.7 KOO30354.1 - 0.11 11.5 0.0 0.14 11.1 0.0 1.1 1 0 0 1 1 1 0 Bacterial shufflon protein, N-terminal constant region CBS PF00571.23 KOO30355.1 - 1.1e-24 85.9 4.5 1.2e-09 37.8 0.0 4.3 4 0 0 4 4 4 4 CBS domain DUF639 PF04842.7 KOO30355.1 - 0.057 11.5 0.1 0.082 11.0 0.1 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) Peptidase_C69 PF03577.10 KOO30356.1 - 5.2e-50 170.4 0.6 3e-49 167.9 0.0 2.3 1 1 1 2 2 2 1 Peptidase family C69 Mtc PF03820.12 KOO30358.1 - 8.7e-23 80.4 0.0 9.7e-23 80.2 0.0 1.1 1 0 0 1 1 1 1 Tricarboxylate carrier Asp PF00026.18 KOO30359.1 - 8.5e-27 94.2 0.0 2.4e-26 92.7 0.0 1.7 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 KOO30359.1 - 0.00019 21.4 0.0 0.00042 20.2 0.0 1.6 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 KOO30359.1 - 0.016 14.7 0.0 0.071 12.6 0.0 2.0 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal Hexapep PF00132.19 KOO30360.1 - 1.6e-20 71.6 23.1 5.3e-08 32.0 1.2 4.9 4 1 2 6 6 6 5 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 KOO30360.1 - 0.00037 19.9 6.2 0.002 17.6 1.8 4.1 3 1 1 4 4 4 2 Hexapeptide repeat of succinyl-transferase CHAT PF12770.2 KOO30361.1 - 5.3e-07 29.0 0.0 9.5e-07 28.2 0.0 1.3 1 0 0 1 1 1 1 CHAT domain GBP PF02263.14 KOO30361.1 - 0.00053 19.1 0.0 0.00074 18.6 0.0 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain EF-hand_6 PF13405.1 KOO30362.1 - 1.3e-25 86.8 1.5 4.9e-06 25.9 0.0 4.8 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.27 KOO30362.1 - 1.1e-23 80.6 0.0 4.4e-05 22.4 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO30362.1 - 3.7e-20 71.8 0.6 1.4e-08 34.7 0.1 2.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO30362.1 - 5e-19 66.7 0.4 0.00092 18.4 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO30362.1 - 1.7e-18 65.9 1.9 2.9e-08 33.2 0.0 3.7 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_10 PF14788.1 KOO30362.1 - 0.0019 17.8 0.0 3.1 7.5 0.0 3.6 3 1 0 3 3 3 1 EF hand EF-hand_9 PF14658.1 KOO30362.1 - 0.012 15.5 0.0 0.35 10.7 0.0 2.8 2 1 1 3 3 3 0 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO30362.1 - 0.089 12.8 0.1 31 4.6 0.0 3.1 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO30362.1 - 0.15 11.8 0.2 2.8 7.7 0.0 2.5 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand FoP_duplication PF13865.1 KOO30363.1 - 7.7e-05 23.0 14.7 0.023 15.1 5.9 2.4 1 1 1 2 2 2 2 C-terminal duplication domain of Friend of PRMT1 DUF2763 PF10961.3 KOO30363.1 - 0.14 12.5 3.4 0.17 12.3 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2763) zf-PARP PF00645.13 KOO30364.1 - 1.3e-10 41.3 0.8 1.5e-07 31.5 0.1 2.9 1 1 1 2 2 2 2 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region ASFV_J13L PF05568.6 KOO30364.1 - 1.1 8.8 3.4 1.3 8.5 0.6 2.1 2 0 0 2 2 2 0 African swine fever virus J13L protein Sterol-sensing PF12349.3 KOO30365.1 - 2.5e-05 23.7 9.9 4.8e-05 22.8 6.8 1.5 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.13 KOO30365.1 - 0.00088 17.3 1.2 0.001 17.0 0.1 1.5 1 1 0 1 1 1 1 Patched family DsrD PF08679.6 KOO30365.1 - 0.0082 16.1 0.0 0.26 11.3 0.0 2.2 2 0 0 2 2 2 1 Dissimilatory sulfite reductase D (DsrD) MMPL PF03176.10 KOO30365.1 - 0.22 10.2 7.8 0.37 9.4 5.4 1.3 1 0 0 1 1 1 0 MMPL family Patched PF02460.13 KOO30366.1 - 0.00013 20.1 16.1 0.00017 19.7 11.2 1.1 1 0 0 1 1 1 1 Patched family Sugar_tr PF00083.19 KOO30367.1 - 6e-17 61.3 10.2 6e-13 48.1 0.2 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter Cyclin_N PF00134.18 KOO30368.1 - 1.1e-12 47.6 0.0 1.7e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.6 KOO30368.1 - 1.8e-09 38.1 0.0 2.7e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Cyclin SKG6 PF08693.5 KOO30369.1 - 0.038 13.2 2.6 0.099 11.9 1.8 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Adeno_E3_CR2 PF02439.10 KOO30369.1 - 2.1 7.9 6.5 0.19 11.3 0.8 2.0 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 DUF445 PF04286.7 KOO30371.1 - 0.8 9.1 6.3 15 4.9 3.3 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF445) EF-hand_5 PF13202.1 KOO30372.1 - 2e-14 52.1 1.9 4e-05 22.7 0.2 3.7 3 0 0 3 3 3 3 EF hand EF-hand_1 PF00036.27 KOO30372.1 - 1.3e-13 49.1 2.4 0.00068 18.7 0.2 3.9 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.1 KOO30372.1 - 2.8e-12 46.5 0.0 1.9e-08 34.3 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO30372.1 - 1e-11 44.2 0.5 0.016 14.8 0.0 4.2 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO30372.1 - 3.4e-11 42.0 3.0 0.0021 17.7 0.3 4.6 4 0 0 4 4 4 3 EF-hand domain LRR_6 PF13516.1 KOO30372.1 - 0.00015 21.4 1.6 1 9.6 0.1 3.5 4 0 0 4 4 4 2 Leucine Rich repeat CHCH PF06747.8 KOO30372.1 - 0.24 11.3 0.6 0.59 10.1 0.0 2.1 3 0 0 3 3 3 0 CHCH domain Myosin_head PF00063.16 KOO30373.1 - 1.7e-112 376.7 0.0 2e-112 376.5 0.0 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_16 PF13191.1 KOO30373.1 - 0.0018 18.2 2.2 0.0079 16.1 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain T2SE PF00437.15 KOO30373.1 - 0.0024 16.8 0.0 0.0039 16.1 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein Zeta_toxin PF06414.7 KOO30373.1 - 0.02 13.9 0.0 0.04 12.9 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.1 KOO30373.1 - 0.025 14.7 0.1 0.096 12.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain PARP PF00644.15 KOO30374.1 - 2.6e-14 53.1 0.0 5.8e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PTS_2-RNA PF01885.11 KOO30374.1 - 0.013 14.7 0.0 0.024 13.9 0.0 1.3 1 0 0 1 1 1 0 RNA 2'-phosphotransferase, Tpt1 / KptA family THDPS_M PF14789.1 KOO30374.1 - 0.16 11.9 0.6 5 7.1 0.1 2.8 2 0 0 2 2 2 0 Tetrahydrodipicolinate N-succinyltransferase middle DUF1778 PF08681.6 KOO30376.1 - 1.1 9.1 8.6 0.16 11.8 1.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1778) H2TH PF06831.9 KOO30378.1 - 5.6e-12 45.2 0.0 8.9e-12 44.6 0.0 1.3 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Pkinase PF00069.20 KOO30379.1 - 9.4e-10 38.0 0.0 3.5e-09 36.1 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 KOO30379.1 - 0.0012 17.8 0.0 0.0041 16.1 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 KOO30379.1 - 0.0024 16.9 0.0 0.0039 16.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family 2OG-FeII_Oxy_3 PF13640.1 KOO30380.1 - 1.3e-09 38.4 0.0 2.4e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO30380.1 - 1.7e-06 28.2 0.0 2.6e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO30380.1 - 0.02 14.5 0.0 0.041 13.5 0.0 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.8 KOO30380.1 - 0.15 10.7 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Poxvirus C4/C10 protein Pentapeptide_4 PF13599.1 KOO30382.1 - 4.9e-35 119.1 0.0 6.2e-15 54.7 0.0 3.7 1 1 4 5 5 5 4 Pentapeptide repeats (9 copies) Ribosomal_L13e PF01294.13 KOO30382.1 - 0.0014 18.1 2.7 4.4 6.7 0.0 4.6 2 1 2 5 5 5 2 Ribosomal protein L13e LytR_C PF13399.1 KOO30382.1 - 0.0058 16.9 4.5 1 9.7 0.1 4.0 2 1 2 4 4 4 1 LytR cell envelope-related transcriptional attenuator N_methyl_2 PF13544.1 KOO30382.1 - 0.017 14.6 3.1 0.82 9.2 0.0 4.2 4 0 0 4 4 4 0 Type IV pilin N-term methylation site GFxxxE RPAP1_C PF08620.5 KOO30382.1 - 0.071 12.9 0.0 59 3.6 0.0 3.7 3 1 1 4 4 4 0 RPAP1-like, C-terminal MerR-DNA-bind PF09278.6 KOO30382.1 - 0.12 12.7 4.0 14 6.1 0.0 4.6 5 1 0 5 5 5 0 MerR, DNA binding Pentapeptide PF00805.17 KOO30382.1 - 1.2 8.4 5.0 1.3 8.3 0.2 3.2 4 0 0 4 4 4 0 Pentapeptide repeats (8 copies) Clp_N PF02861.15 KOO30382.1 - 1.4 8.8 3.9 59 3.7 0.0 4.0 4 0 0 4 4 4 0 Clp amino terminal domain Porin_3 PF01459.17 KOO30383.1 - 3.9e-51 173.9 0.1 4.4e-51 173.7 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic porin OprB PF04966.7 KOO30383.1 - 0.0024 17.0 4.0 0.0084 15.2 2.4 1.8 2 0 0 2 2 2 1 Carbohydrate-selective porin, OprB family DAGK_cat PF00781.19 KOO30384.1 - 1.6e-18 66.4 0.0 3.3e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain PT PF04886.7 KOO30384.1 - 0.0082 15.4 10.9 0.016 14.4 7.6 1.4 1 0 0 1 1 1 1 PT repeat BASP1 PF05466.7 KOO30384.1 - 8.7 6.0 13.8 13 5.5 9.5 1.1 1 0 0 1 1 1 0 Brain acid soluble protein 1 (BASP1 protein) DEC-1_N PF04625.8 KOO30384.1 - 8.9 4.8 11.5 13 4.2 8.0 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Peptidase_M8 PF01457.11 KOO30385.1 - 8.7e-17 60.6 0.1 1.4e-16 59.9 0.1 1.2 1 0 0 1 1 1 1 Leishmanolysin Astacin PF01400.19 KOO30385.1 - 0.1 11.9 0.2 0.22 10.9 0.1 1.4 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Tetraspannin PF00335.15 KOO30385.1 - 0.95 8.6 12.1 1.3 8.2 7.1 2.1 2 0 0 2 2 2 0 Tetraspanin family Reprolysin_3 PF13582.1 KOO30385.1 - 2.1 8.8 7.1 1.4 9.5 0.3 2.6 3 0 0 3 3 3 0 Metallo-peptidase family M12B Reprolysin-like IMS PF00817.15 KOO30386.1 - 1.8e-35 121.9 0.1 3.8e-35 120.8 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family IMS_HHH PF11798.3 KOO30386.1 - 2.2e-07 30.5 0.0 6.3e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 IMS family HHH motif BCAS2 PF05700.6 KOO30386.1 - 0.059 12.8 0.2 0.088 12.2 0.2 1.2 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 2 (BCAS2) Peptidase_C1 PF00112.18 KOO30387.1 - 5.4e-71 238.9 1.5 7.3e-71 238.5 1.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KOO30387.1 - 9e-13 48.2 0.1 1.5e-12 47.5 0.1 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.10 KOO30387.1 - 5.1e-07 28.5 1.7 0.0001 20.9 0.0 3.2 2 1 1 3 3 3 3 Peptidase C1-like family Rad60-SLD PF11976.3 KOO30388.1 - 2.2e-26 91.3 0.1 2.6e-26 91.0 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 KOO30388.1 - 2.3e-09 36.4 0.0 2.8e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family RNA_Me_trans PF04252.8 KOO30388.1 - 0.022 14.1 0.0 0.025 14.0 0.0 1.1 1 0 0 1 1 1 0 Predicted SAM-dependent RNA methyltransferase zf-CCHC PF00098.18 KOO30389.1 - 6.5e-06 25.8 14.3 0.00026 20.7 0.7 2.2 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.1 KOO30389.1 - 0.0022 17.5 11.5 0.0041 16.7 0.7 2.2 2 0 0 2 2 2 2 Zinc knuckle zinc-ribbons_6 PF07191.7 KOO30389.1 - 0.062 13.0 3.4 0.18 11.5 2.4 1.7 1 1 0 1 1 1 0 zinc-ribbons DnaJ_CXXCXGXG PF00684.14 KOO30389.1 - 0.17 11.9 8.3 0.24 11.4 5.7 1.2 1 0 0 1 1 1 0 DnaJ central domain zf-CCHC_3 PF13917.1 KOO30389.1 - 0.24 11.1 0.1 0.24 11.1 0.1 2.3 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.1 KOO30389.1 - 3.2 7.3 7.6 6.3 6.3 1.2 2.2 2 0 0 2 2 2 0 Zinc knuckle Mre11_DNA_bind PF04152.9 KOO30390.1 - 2.1e-19 70.0 0.2 6.9e-18 65.1 0.0 2.5 2 1 0 2 2 2 2 Mre11 DNA-binding presumed domain Trichoplein PF13868.1 KOO30391.1 - 0.0022 16.4 105.4 0.0029 16.0 73.0 1.2 1 0 0 1 1 1 1 Tumour suppressor, Mitostatin SET PF00856.23 KOO30392.1 - 1.6e-07 31.7 0.5 4.1e-07 30.4 0.2 1.8 2 0 0 2 2 2 1 SET domain zf-NADH-PPase PF09297.6 KOO30392.1 - 0.43 10.1 15.0 1.5 8.4 1.2 2.7 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain rve PF00665.21 KOO30393.1 - 1.1e-07 32.0 0.0 3e-07 30.5 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RVT_2 PF07727.9 KOO30393.1 - 0.0046 15.9 0.0 0.0076 15.2 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Glyco_transf_8 PF01501.15 KOO30394.1 - 1.1e-28 100.3 0.0 1.6e-28 99.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.3 KOO30394.1 - 0.0028 17.0 0.1 0.0052 16.1 0.0 1.3 1 0 0 1 1 1 1 Mannosyltransferase putative MRP-L47 PF06984.8 KOO30394.1 - 0.0062 16.4 0.4 0.012 15.5 0.3 1.4 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) MT PF12777.2 KOO30395.1 - 4.8e-05 22.2 0.0 6.9e-05 21.7 0.0 1.1 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor PUB PF09409.5 KOO30396.1 - 2e-11 43.4 0.0 3.8e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 PUB domain UBX PF00789.15 KOO30396.1 - 0.012 15.6 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 UBX domain ClpS PF02617.12 KOO30397.1 - 4.5e-10 39.1 0.0 7.9e-10 38.3 0.0 1.3 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS PMSR PF01625.16 KOO30399.1 - 8.9e-09 35.4 0.1 2.1e-08 34.1 0.1 1.6 1 1 0 1 1 1 1 Peptide methionine sulfoxide reductase WD40 PF00400.27 KOO30400.1 - 2.9e-51 169.6 23.7 1.3e-11 43.9 0.0 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat AAA_16 PF13191.1 KOO30400.1 - 4.4e-10 39.8 1.2 4.6e-09 36.5 0.1 2.9 2 0 0 2 2 2 1 AAA ATPase domain PD40 PF07676.7 KOO30400.1 - 1.4e-07 31.0 0.2 5.4 6.7 0.0 4.9 4 0 0 4 4 4 4 WD40-like Beta Propeller Repeat NACHT PF05729.7 KOO30400.1 - 1.4e-07 31.3 0.0 3.1e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain KAP_NTPase PF07693.9 KOO30400.1 - 0.045 12.7 0.0 0.22 10.4 0.0 1.9 2 0 0 2 2 2 0 KAP family P-loop domain Amidinotransf PF02274.12 KOO30400.1 - 0.045 12.8 0.0 0.93 8.5 0.0 2.3 2 0 0 2 2 2 0 Amidinotransferase TFIIIC_delta PF12657.2 KOO30400.1 - 0.09 12.4 2.9 0.23 11.1 1.1 2.2 2 0 0 2 2 2 0 Transcription factor IIIC subunit delta N-term Coatomer_WDAD PF04053.9 KOO30400.1 - 0.14 10.8 0.1 0.47 9.1 0.0 1.8 2 0 0 2 2 2 0 Coatomer WD associated region zf-TFIIB PF13453.1 KOO30400.1 - 0.15 11.2 0.4 1.6 7.9 0.0 2.8 3 0 0 3 3 3 0 Transcription factor zinc-finger MIP-T3 PF10243.4 KOO30400.1 - 0.24 9.8 2.2 0.39 9.1 1.6 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 EF-hand_7 PF13499.1 KOO30402.1 - 1e-11 44.7 0.0 8.4e-08 32.2 0.0 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO30402.1 - 2.3e-11 42.0 0.0 2.4e-05 23.2 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO30402.1 - 3.2e-11 42.0 0.1 8.9e-06 24.8 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO30402.1 - 2.5e-09 36.2 0.2 0.00066 19.3 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO30402.1 - 5.2e-06 25.9 0.1 0.02 14.5 0.0 2.5 1 1 1 2 2 2 2 EF-hand domain pair LRR_6 PF13516.1 KOO30402.1 - 7.6e-05 22.3 2.2 0.54 10.5 0.1 3.4 3 0 0 3 3 3 2 Leucine Rich repeat LRR_4 PF12799.2 KOO30402.1 - 0.00012 21.5 1.4 0.004 16.7 1.8 2.5 3 0 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO30402.1 - 0.032 13.9 0.1 0.096 12.4 0.1 1.8 1 0 0 1 1 1 0 Leucine rich repeat LRR_1 PF00560.28 KOO30402.1 - 0.091 12.8 0.8 10 6.5 0.1 3.0 2 0 0 2 2 2 0 Leucine Rich Repeat NETI PF14044.1 KOO30402.1 - 0.15 11.5 0.0 0.37 10.3 0.0 1.6 1 0 0 1 1 1 0 NETI protein KH_1 PF00013.24 KOO30403.1 - 5.9e-17 61.0 0.1 1.2e-06 27.9 0.0 3.4 3 0 0 3 3 3 2 KH domain KH_3 PF13014.1 KOO30403.1 - 3.4e-13 48.8 0.6 1.1e-05 24.9 0.0 2.8 2 0 0 2 2 2 2 KH domain KH_2 PF07650.12 KOO30403.1 - 8.9e-05 21.9 0.2 0.29 10.7 0.0 2.4 2 0 0 2 2 2 2 KH domain KH_4 PF13083.1 KOO30403.1 - 0.0031 17.1 0.1 0.63 9.7 0.0 2.4 2 0 0 2 2 2 2 KH domain Notch PF00066.12 KOO30404.1 - 2.8e-32 110.6 85.6 2e-07 31.1 9.7 5.6 5 0 0 5 5 5 5 LNR domain Kringle PF00051.13 KOO30404.1 - 1.1e-29 102.2 6.8 1.9e-20 72.7 0.4 2.7 2 0 0 2 2 2 2 Kringle domain Glyco_transf_8 PF01501.15 KOO30404.1 - 9.4e-11 41.5 0.0 1.7e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Ion_trans PF00520.26 KOO30405.1 - 1.5e-174 576.0 63.2 3.3e-48 163.6 0.1 4.5 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 KOO30405.1 - 2.9e-11 42.4 71.6 2.1e-08 32.9 0.8 8.5 7 2 2 9 9 9 8 Polycystin cation channel Kinesin PF00225.18 KOO30406.1 - 7.8e-20 70.8 0.0 1.4e-18 66.6 0.0 2.3 1 1 0 1 1 1 1 Kinesin motor domain TPR_12 PF13424.1 KOO30406.1 - 8.2e-14 51.3 13.8 5.9e-10 38.9 4.1 3.1 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.1 KOO30406.1 - 4.2e-09 36.0 21.1 0.00042 20.1 2.4 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO30406.1 - 0.0002 21.0 6.8 0.37 10.8 0.7 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO30406.1 - 0.00021 20.8 4.5 0.0032 17.0 0.8 3.0 2 1 0 2 2 2 1 TPR repeat TPR_1 PF00515.23 KOO30406.1 - 0.00074 19.0 1.1 0.26 10.9 0.5 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO30406.1 - 0.16 11.8 5.4 24 5.0 0.4 4.4 3 1 0 3 3 3 0 Tetratricopeptide repeat AAA_22 PF13401.1 KOO30406.1 - 0.26 11.4 3.2 0.58 10.3 0.6 2.7 3 0 0 3 3 3 0 AAA domain MscS_porin PF12795.2 KOO30406.1 - 0.69 9.1 14.1 0.78 9.0 6.5 2.3 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain Alk_phosphatase PF00245.15 KOO30407.1 - 2.8e-92 309.6 0.0 4e-82 276.1 0.0 2.3 2 0 0 2 2 2 2 Alkaline phosphatase Sulfatase PF00884.18 KOO30407.1 - 0.00054 19.2 0.0 0.00074 18.7 0.0 1.3 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.13 KOO30407.1 - 0.00059 19.2 0.0 0.0015 18.0 0.0 1.6 2 0 0 2 2 2 1 Metalloenzyme superfamily Laminin_G_3 PF13385.1 KOO30410.1 - 1.3e-08 35.2 0.0 1.8e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily EXS PF03124.9 KOO30411.1 - 8.5e-65 219.0 11.7 1.1e-64 218.6 8.1 1.1 1 0 0 1 1 1 1 EXS family WW PF00397.21 KOO30412.1 - 2.1e-06 27.4 5.0 3.2e-06 26.8 3.5 1.3 1 0 0 1 1 1 1 WW domain UQ_con PF00179.21 KOO30413.1 - 4.9e-40 136.1 0.0 5.5e-40 136.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KOO30413.1 - 8.9e-05 22.2 0.0 0.00012 21.8 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UFC1 PF08694.6 KOO30413.1 - 0.031 13.7 0.0 0.035 13.5 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.17 KOO30413.1 - 0.068 13.0 0.1 0.087 12.7 0.1 1.3 1 0 0 1 1 1 0 RWD domain Bclt PF15318.1 KOO30414.1 - 0.037 14.0 0.2 0.057 13.4 0.1 1.4 1 0 0 1 1 1 0 Putative Bcl-2 like protein of testis HSP70 PF00012.15 KOO30416.1 - 1.9e-142 475.2 0.9 2.1e-142 475.0 0.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 KOO30416.1 - 2.1e-11 43.0 0.0 4.9e-10 38.5 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.13 KOO30416.1 - 0.032 13.3 0.2 0.065 12.3 0.0 1.6 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase DDR PF08841.5 KOO30416.1 - 0.06 12.1 0.1 0.094 11.5 0.0 1.3 1 0 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain StbA PF06406.6 KOO30416.1 - 0.097 11.5 0.0 0.15 10.9 0.0 1.3 1 0 0 1 1 1 0 StbA protein SRI PF08236.6 KOO30416.1 - 0.14 12.1 0.8 0.48 10.3 0.1 2.0 2 0 0 2 2 2 0 SRI (Set2 Rpb1 interacting) domain FtsA PF14450.1 KOO30416.1 - 0.38 10.6 1.8 3.9 7.3 1.3 2.7 1 1 0 1 1 1 0 Cell division protein FtsA DUF4381 PF14316.1 KOO30418.1 - 7.4e-07 29.3 1.6 8.9e-07 29.1 1.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) T2SM PF04612.7 KOO30418.1 - 0.00087 19.1 2.7 0.0012 18.6 1.9 1.3 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein M SKG6 PF08693.5 KOO30418.1 - 0.0077 15.5 0.5 0.013 14.8 0.3 1.3 1 0 0 1 1 1 1 Transmembrane alpha-helix domain UPF0104 PF03706.8 KOO30418.1 - 0.012 14.9 0.2 0.013 14.8 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0104) DUF1049 PF06305.6 KOO30418.1 - 0.014 14.8 2.7 0.022 14.2 1.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) MASE1 PF05231.9 KOO30418.1 - 0.014 14.4 0.2 0.019 14.0 0.1 1.1 1 0 0 1 1 1 0 MASE1 DUF2681 PF10883.3 KOO30418.1 - 0.016 15.4 0.2 0.026 14.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) DUF347 PF03988.7 KOO30418.1 - 0.031 14.1 0.2 0.043 13.6 0.2 1.2 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) MFS_1 PF07690.11 KOO30418.1 - 0.033 12.9 0.0 0.033 12.9 0.0 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily SIT PF15330.1 KOO30418.1 - 0.033 14.3 0.3 0.048 13.7 0.2 1.3 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT RRF_GI PF12614.3 KOO30418.1 - 0.038 13.8 0.7 0.053 13.3 0.5 1.1 1 0 0 1 1 1 0 Ribosome recycling factor DUF2762 PF10960.3 KOO30418.1 - 0.056 13.1 0.2 0.074 12.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2762) YajC PF02699.10 KOO30418.1 - 0.057 13.0 0.2 0.084 12.5 0.2 1.3 1 0 0 1 1 1 0 Preprotein translocase subunit DUF4131 PF13567.1 KOO30418.1 - 0.06 12.7 0.1 0.073 12.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Vpu PF00558.14 KOO30418.1 - 0.091 12.3 0.2 0.15 11.6 0.1 1.4 1 0 0 1 1 1 0 Vpu protein DUF2868 PF11067.3 KOO30418.1 - 0.1 11.7 4.6 0.14 11.3 3.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2868) BatD PF13584.1 KOO30418.1 - 0.11 11.1 0.2 0.13 10.7 0.1 1.1 1 0 0 1 1 1 0 Oxygen tolerance EphA2_TM PF14575.1 KOO30418.1 - 0.11 12.8 0.0 0.16 12.4 0.0 1.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain BatA PF07584.6 KOO30418.1 - 1.6 9.0 5.7 2.6 8.3 4.0 1.4 1 1 0 1 1 1 0 Aerotolerance regulator N-terminal CcmD PF04995.9 KOO30418.1 - 1.8 8.3 7.3 3.8 7.3 5.1 1.6 1 1 0 1 1 1 0 Heme exporter protein D (CcmD) DUF2937 PF11157.3 KOO30418.1 - 3.9 6.7 6.8 11 5.3 1.4 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF2937) TPR_1 PF00515.23 KOO30419.1 - 2.3e-25 87.1 14.5 2e-06 27.1 0.0 10.2 11 1 0 11 11 11 5 Tetratricopeptide repeat TPR_11 PF13414.1 KOO30419.1 - 7.6e-24 83.1 17.3 1.3e-11 43.9 0.3 6.4 3 1 3 6 6 6 5 TPR repeat TPR_2 PF07719.12 KOO30419.1 - 5.3e-22 75.9 17.1 4e-06 26.3 0.0 9.0 10 0 0 10 10 8 5 Tetratricopeptide repeat TPR_8 PF13181.1 KOO30419.1 - 7.6e-20 69.1 0.8 0.00031 20.3 0.0 9.4 10 1 1 11 11 10 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOO30419.1 - 2.2e-16 58.8 17.5 0.0012 19.2 0.2 8.5 6 2 3 9 9 8 5 Tetratricopeptide repeat TPR_16 PF13432.1 KOO30419.1 - 4.8e-15 55.7 18.1 2.3e-07 31.2 0.4 6.1 4 2 4 8 8 7 5 Tetratricopeptide repeat TPR_12 PF13424.1 KOO30419.1 - 1.6e-13 50.3 20.4 1.2e-05 25.1 0.5 6.7 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_7 PF13176.1 KOO30419.1 - 2.2e-13 48.8 7.0 0.0002 20.9 0.0 7.1 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOO30419.1 - 1.2e-12 47.4 2.5 0.077 13.4 0.0 7.2 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO30419.1 - 1.6e-12 46.5 5.0 0.032 14.4 0.0 7.9 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_21 PF09976.4 KOO30419.1 - 2.2e-12 47.1 2.8 0.00051 20.0 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOO30419.1 - 4e-12 46.3 7.8 0.0012 19.1 0.2 5.4 5 2 2 7 7 6 5 Tetratricopeptide repeat TPR_15 PF13429.1 KOO30419.1 - 2.7e-08 33.2 4.2 0.082 11.9 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat Apc3 PF12895.2 KOO30419.1 - 4e-06 26.8 7.9 0.0029 17.7 0.1 4.1 4 1 1 5 5 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 KOO30419.1 - 2.2e-05 24.2 19.2 0.013 15.2 1.9 6.5 5 2 2 7 7 7 2 Tetratricopeptide repeat FAT PF02259.18 KOO30419.1 - 2.9e-05 23.2 0.1 0.09 11.7 0.0 3.1 3 1 0 3 3 3 2 FAT domain TPR_20 PF14561.1 KOO30419.1 - 0.0017 18.4 2.7 1.9 8.6 0.2 3.4 2 2 1 3 3 3 2 Tetratricopeptide repeat TOM20_plant PF06552.7 KOO30419.1 - 0.03 13.9 0.3 13 5.3 0.0 3.8 3 1 1 4 4 3 0 Plant specific mitochondrial import receptor subunit TOM20 SNAP PF14938.1 KOO30419.1 - 0.068 12.3 5.8 3.6 6.6 0.0 3.5 3 1 0 3 3 3 0 Soluble NSF attachment protein, SNAP ChAPs PF09295.5 KOO30419.1 - 0.073 11.8 0.0 0.19 10.4 0.0 1.7 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) Coatomer_WDAD PF04053.9 KOO30419.1 - 0.21 10.3 0.8 0.32 9.7 0.0 1.6 2 0 0 2 2 2 0 Coatomer WD associated region TPR_10 PF13374.1 KOO30419.1 - 0.35 10.8 7.4 3.4 7.7 0.2 4.4 5 0 0 5 5 3 0 Tetratricopeptide repeat DUF1052 PF06319.7 KOO30420.1 - 0.046 12.9 0.0 0.089 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1052) TRM PF02005.11 KOO30421.1 - 1.8e-57 194.9 0.0 2.2e-57 194.6 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase WES_acyltransf PF03007.11 KOO30422.1 - 1.6e-10 41.0 0.1 1.6e-10 41.0 0.1 3.0 3 1 1 4 4 4 1 Wax ester synthase-like Acyl-CoA acyltransferase domain DUF1298 PF06974.8 KOO30422.1 - 9.1e-08 32.0 0.0 1.7e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1298) Condensation PF00668.15 KOO30422.1 - 0.00014 20.8 0.0 0.0076 15.1 0.0 2.3 2 0 0 2 2 2 2 Condensation domain DUF4095 PF13338.1 KOO30422.1 - 0.42 10.7 4.8 18 5.5 0.1 3.2 3 1 1 4 4 4 0 Domain of unknown function (DUF4095) HEAT_2 PF13646.1 KOO30425.1 - 1e-06 28.9 9.1 0.00045 20.4 1.5 3.1 2 1 1 3 3 3 2 HEAT repeats HEAT PF02985.17 KOO30425.1 - 0.00038 20.2 6.8 0.089 12.9 0.1 4.4 4 0 0 4 4 4 2 HEAT repeat Methyltransf_24 PF13578.1 KOO30428.1 - 3e-07 31.2 0.0 4e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain zf-C3HC4_3 PF13920.1 KOO30429.1 - 4.1e-12 45.5 8.3 4.1e-12 45.5 5.8 1.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO30429.1 - 1.2e-06 28.4 9.3 2.1e-06 27.6 6.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO30429.1 - 2.2e-05 24.1 9.4 4.7e-05 23.1 6.5 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 KOO30429.1 - 0.0048 16.5 7.9 0.0089 15.7 5.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 KOO30429.1 - 0.049 13.3 5.4 0.1 12.3 3.7 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.1 KOO30429.1 - 0.14 12.0 9.1 0.25 11.2 6.3 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING PhyH PF05721.8 KOO30432.1 - 1.7e-14 54.3 0.0 6.3e-14 52.5 0.0 1.8 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) TauD PF02668.11 KOO30432.1 - 0.078 12.6 0.0 4.4 6.8 0.0 2.5 2 1 0 2 2 2 0 Taurine catabolism dioxygenase TauD, TfdA family SNF2_N PF00176.18 KOO30433.1 - 7.8e-15 54.4 0.0 2e-08 33.3 0.0 2.2 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.26 KOO30433.1 - 4.2e-12 45.7 0.0 7.3e-12 44.9 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain CS PF04969.11 KOO30434.1 - 7.6e-07 29.5 0.0 1.5e-06 28.6 0.0 1.5 1 1 0 1 1 1 1 CS domain eIF3_subunit PF08597.5 KOO30434.1 - 0.11 12.0 24.5 0.37 10.2 17.0 1.8 1 1 0 1 1 1 0 Translation initiation factor eIF3 subunit Ycf1 PF05758.7 KOO30434.1 - 7.3 4.1 8.7 8.8 3.8 6.0 1.1 1 0 0 1 1 1 0 Ycf1 EII-Sor PF03609.9 KOO30435.1 - 0.0017 17.7 3.5 0.0028 16.9 2.4 1.3 1 0 0 1 1 1 1 PTS system sorbose-specific iic component Laminin_G_3 PF13385.1 KOO30436.1 - 0.025 14.8 0.0 0.043 14.0 0.0 1.3 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily Lectin_legB PF00139.14 KOO30436.1 - 0.047 13.0 0.0 0.16 11.3 0.0 1.8 2 0 0 2 2 2 0 Legume lectin domain Laminin_G_2 PF02210.19 KOO30436.1 - 0.077 13.0 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Laminin G domain Inositol_P PF00459.20 KOO30438.1 - 1.6e-35 122.7 0.1 2.4e-35 122.1 0.0 1.2 1 0 0 1 1 1 1 Inositol monophosphatase family Ion_trans_2 PF07885.11 KOO30439.1 - 6.2e-06 25.8 16.0 4.9e-05 22.9 2.8 2.5 2 0 0 2 2 2 2 Ion channel Ribosomal_S5_C PF03719.10 KOO30441.1 - 2.5e-24 84.3 0.1 6.6e-24 82.9 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.15 KOO30441.1 - 2.8e-24 84.6 0.2 5.2e-24 83.7 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain IKKbetaNEMObind PF12179.3 KOO30442.1 - 0.3 10.9 1.7 0.59 9.9 1.2 1.5 1 0 0 1 1 1 0 I-kappa-kinase-beta NEMO binding domain Herpes_UL35 PF04496.7 KOO30442.1 - 0.47 10.6 3.6 5.3 7.3 2.9 2.1 2 0 0 2 2 2 0 Herpesvirus UL35 family ADK PF00406.17 KOO30443.1 - 0.0006 19.7 0.0 0.00066 19.5 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase Na_H_antiporter PF03553.9 KOO30444.1 - 3.2e-40 138.0 7.9 3.2e-40 138.0 5.5 2.1 1 1 1 2 2 2 2 Na+/H+ antiporter family DnaJ PF00226.26 KOO30445.1 - 6.6e-22 77.0 0.7 1e-21 76.4 0.2 1.6 2 0 0 2 2 2 1 DnaJ domain TPR_11 PF13414.1 KOO30445.1 - 4.4e-07 29.4 8.6 0.00086 18.9 0.0 3.9 2 2 2 4 4 4 3 TPR repeat TPR_2 PF07719.12 KOO30445.1 - 4.5e-05 23.0 4.6 0.16 11.9 0.0 4.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO30445.1 - 0.00025 20.5 0.2 0.12 11.9 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO30445.1 - 0.024 15.2 1.7 0.024 15.2 1.2 4.7 4 1 1 5 5 5 0 Tetratricopeptide repeat SecA_DEAD PF07517.9 KOO30446.1 - 1.4e-07 31.1 2.8 3.2e-07 29.9 0.0 3.1 3 1 1 4 4 4 1 SecA DEAD-like domain Glyco_hydro_97 PF10566.4 KOO30446.1 - 0.046 12.8 0.3 4.6 6.2 0.0 2.3 2 0 0 2 2 2 0 Glycoside hydrolase 97 TauE PF01925.14 KOO30448.1 - 6.3e-21 74.9 37.2 7.3e-12 45.2 1.5 2.2 2 0 0 2 2 2 2 Sulfite exporter TauE/SafE RRM_1 PF00076.17 KOO30449.1 - 0.00065 19.2 0.0 0.0013 18.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO30449.1 - 0.0023 17.7 0.0 0.0041 16.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO30449.1 - 0.015 15.2 0.0 0.032 14.2 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Calcipressin PF04847.7 KOO30449.1 - 0.022 14.3 0.0 0.035 13.6 0.0 1.2 1 0 0 1 1 1 0 Calcipressin LRR_8 PF13855.1 KOO30450.1 - 1.1e-06 28.2 4.7 9.8e-06 25.2 0.2 2.7 2 0 0 2 2 2 1 Leucine rich repeat LRR_6 PF13516.1 KOO30450.1 - 0.052 13.6 0.5 5.3 7.4 0.0 4.0 4 0 0 4 4 4 0 Leucine Rich repeat LRR_4 PF12799.2 KOO30450.1 - 0.053 13.1 0.1 0.053 13.1 0.1 3.4 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO30450.1 - 0.13 12.3 0.2 1.1 9.5 0.0 2.7 2 0 0 2 2 2 0 Leucine Rich Repeat TRP PF06011.7 KOO30450.1 - 1.4 7.3 6.7 0.11 11.0 1.0 1.7 2 0 0 2 2 2 0 Transient receptor potential (TRP) ion channel EF-hand_1 PF00036.27 KOO30452.1 - 3.4e-13 47.8 6.7 8.4e-05 21.6 0.0 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 KOO30452.1 - 4.6e-13 47.8 2.8 0.0053 16.5 0.1 3.8 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.1 KOO30452.1 - 3.2e-09 36.7 3.3 0.00062 19.8 0.9 3.7 3 1 1 4 4 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO30452.1 - 2.6e-07 30.1 1.8 0.0021 17.6 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO30452.1 - 3.1e-06 26.2 9.9 0.01 15.1 0.1 3.9 4 0 0 4 4 4 2 EF hand YjcZ PF13990.1 KOO30452.1 - 0.0065 15.6 2.4 0.022 13.8 0.0 2.3 2 0 0 2 2 2 1 YjcZ-like protein Tower PF09121.5 KOO30452.1 - 0.017 15.0 1.6 0.055 13.4 1.1 1.9 1 0 0 1 1 1 0 Tower RGS-like PF09128.6 KOO30452.1 - 0.074 12.5 0.2 0.074 12.5 0.2 2.4 2 0 0 2 2 2 0 Regulator of G protein signalling-like domain ALMT PF11744.3 KOO30452.1 - 0.44 9.1 7.2 1.3 7.6 0.2 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter TMPIT PF07851.8 KOO30452.1 - 1 8.3 7.3 2 7.4 0.1 2.1 2 0 0 2 2 2 0 TMPIT-like protein SNARE PF05739.14 KOO30452.1 - 4.2 7.1 11.1 3.3 7.4 0.5 2.5 2 0 0 2 2 2 0 SNARE domain OmpH PF03938.9 KOO30452.1 - 5.3 6.9 19.4 11 5.8 9.4 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) ParB PF08775.5 KOO30452.1 - 5.9 7.2 10.5 6 7.1 1.7 2.5 2 0 0 2 2 2 0 ParB family EF-hand_1 PF00036.27 KOO30454.1 - 1e-09 36.9 1.0 0.00046 19.2 0.1 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO30454.1 - 2.9e-09 36.4 2.9 1.3e-05 24.6 0.3 2.6 1 1 1 2 2 2 2 EF-hand domain pair FAST_1 PF06743.10 KOO30454.1 - 6.6e-09 35.3 0.2 0.0033 17.0 0.1 4.0 3 2 2 5 5 5 3 FAST kinase-like protein, subdomain 1 EF-hand_7 PF13499.1 KOO30454.1 - 1.3e-08 34.8 0.2 2.3e-08 34.0 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO30454.1 - 3.5e-08 32.6 0.0 0.00016 21.3 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO30454.1 - 0.0045 16.2 0.3 0.0045 16.2 0.2 2.3 2 1 0 2 2 2 1 EF hand EF-hand_9 PF14658.1 KOO30454.1 - 0.0075 16.1 0.0 0.022 14.6 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain HEAT_PBS PF03130.11 KOO30454.1 - 0.36 11.4 3.7 8 7.2 0.6 3.6 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat Pkinase PF00069.20 KOO30455.1 - 6.4e-67 225.4 0.0 8.3e-67 225.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO30455.1 - 2.8e-32 111.8 0.0 3.7e-32 111.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO30455.1 - 0.00085 18.3 0.0 0.0023 16.9 0.0 1.6 1 1 1 2 2 2 1 Kinase-like GMC_oxred_N PF00732.14 KOO30457.1 - 9e-52 176.0 0.0 1.5e-51 175.3 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 KOO30457.1 - 6.1e-31 107.6 0.0 1e-30 106.9 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.1 KOO30457.1 - 0.00034 20.5 0.9 0.001 19.0 0.5 2.0 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOO30457.1 - 0.0012 17.8 4.0 0.0012 17.8 2.8 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 KOO30457.1 - 0.011 14.6 5.5 0.063 12.1 1.8 2.1 2 0 0 2 2 2 0 FAD binding domain HI0933_like PF03486.9 KOO30457.1 - 0.036 12.5 0.4 0.065 11.6 0.2 1.4 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_2 PF07992.9 KOO30457.1 - 0.089 12.6 1.3 0.16 11.8 0.9 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GDI PF00996.13 KOO30457.1 - 0.16 10.2 0.0 0.24 9.6 0.0 1.1 1 0 0 1 1 1 0 GDP dissociation inhibitor Thi4 PF01946.12 KOO30457.1 - 0.16 10.9 0.3 0.31 10.1 0.2 1.3 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.7 KOO30457.1 - 0.17 10.8 0.1 0.25 10.2 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_3 PF01494.14 KOO30457.1 - 0.22 10.5 1.4 0.44 9.5 1.0 1.5 1 0 0 1 1 1 0 FAD binding domain HATPase_c_3 PF13589.1 KOO30458.1 - 1e-08 34.9 0.0 2.2e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 KOO30458.1 - 0.00068 19.3 0.0 0.0014 18.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Sporozoite_P67 PF05642.6 KOO30458.1 - 0.13 10.1 0.9 0.27 9.0 0.6 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Ion_trans PF00520.26 KOO30459.1 - 2.9e-16 59.3 5.0 5.4e-16 58.4 3.5 1.5 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO30459.1 - 8.6e-12 44.6 1.4 8.6e-12 44.6 1.0 2.8 4 0 0 4 4 4 1 Ion channel cNMP_binding PF00027.24 KOO30459.1 - 6.4e-08 32.3 0.0 2.9e-07 30.1 0.0 2.1 2 1 0 2 2 2 1 Cyclic nucleotide-binding domain EF-hand_1 PF00036.27 KOO30460.1 - 7.1e-12 43.7 1.9 5.7e-05 22.1 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO30460.1 - 4.2e-11 42.8 0.1 8e-11 41.9 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO30460.1 - 5.9e-10 38.5 0.1 1.2e-09 37.5 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO30460.1 - 2.7e-09 36.1 1.2 2.2e-05 23.9 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO30460.1 - 3.1e-06 26.2 3.2 0.00041 19.5 0.1 2.8 3 0 0 3 3 3 2 EF hand cNMP_binding PF00027.24 KOO30460.1 - 0.014 15.1 0.0 0.029 14.1 0.0 1.4 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain EF-hand_4 PF12763.2 KOO30460.1 - 0.015 15.0 0.0 3.1 7.5 0.0 3.0 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO30460.1 - 0.045 13.7 0.0 0.075 13.0 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Bac_surface_Ag PF01103.18 KOO30461.1 - 1.4e-10 41.1 1.8 8.5e-09 35.3 0.9 2.1 2 0 0 2 2 2 2 Surface antigen POTRA_2 PF08479.6 KOO30461.1 - 0.0015 18.1 0.0 0.0067 16.0 0.0 2.1 1 1 0 1 1 1 1 POTRA domain, ShlB-type Surf_Ag_VNR PF07244.10 KOO30461.1 - 0.054 13.9 0.0 0.19 12.1 0.0 1.8 1 1 0 1 1 1 0 Surface antigen variable number repeat ABC_tran PF00005.22 KOO30462.1 - 7.4e-35 120.2 0.0 1.2e-34 119.5 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 KOO30462.1 - 8.4e-22 77.8 7.3 1.4e-21 77.1 5.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_16 PF13191.1 KOO30462.1 - 0.0015 18.5 0.1 0.0037 17.2 0.1 1.6 1 0 0 1 1 1 1 AAA ATPase domain SbcCD_C PF13558.1 KOO30462.1 - 0.0017 18.2 2.4 0.0054 16.6 0.6 2.6 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit SMC_N PF02463.14 KOO30462.1 - 0.0021 17.3 0.1 0.019 14.1 0.1 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 KOO30462.1 - 0.003 17.5 0.0 0.13 12.1 0.0 2.2 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 KOO30462.1 - 0.011 14.9 0.0 0.027 13.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 KOO30462.1 - 0.013 15.5 0.4 0.14 12.2 0.3 2.2 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.1 KOO30462.1 - 0.017 14.5 0.1 0.12 11.7 0.1 2.3 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.1 KOO30462.1 - 0.021 14.3 0.0 0.063 12.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain zf-HIT PF04438.11 KOO30462.1 - 1.4 8.6 5.0 2.8 7.6 3.5 1.5 1 0 0 1 1 1 0 HIT zinc finger 2-oxoacid_dh PF00198.18 KOO30463.1 - 2.1e-75 252.9 0.0 2.3e-75 252.8 0.0 1.0 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) HTH_10 PF04967.7 KOO30463.1 - 0.086 12.4 0.0 0.2 11.2 0.0 1.6 1 0 0 1 1 1 0 HTH DNA binding domain UQ_con PF00179.21 KOO30464.1 - 4.8e-53 178.3 0.0 5.4e-53 178.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KOO30464.1 - 1.3e-05 24.9 0.0 1.5e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 KOO30464.1 - 8.4e-05 22.4 0.0 9.8e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 KOO30464.1 - 0.043 13.5 0.1 0.066 12.8 0.0 1.3 1 0 0 1 1 1 0 UEV domain Filamin PF00630.14 KOO30465.1 - 2.4e-13 50.5 0.0 0.00081 19.9 0.1 3.8 3 1 0 3 3 3 3 Filamin/ABP280 repeat Dam PF05869.6 KOO30465.1 - 0.0058 16.0 0.0 0.0099 15.3 0.0 1.2 1 0 0 1 1 1 1 DNA N-6-adenine-methyltransferase (Dam) Guanylate_cyc PF00211.15 KOO30466.1 - 1.7e-20 73.1 0.0 2.4e-11 43.3 0.0 2.4 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain cNMP_binding PF00027.24 KOO30466.1 - 1.9e-18 66.0 0.1 4.2e-18 64.9 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain AAA_16 PF13191.1 KOO30466.1 - 5e-10 39.6 1.0 5e-10 39.6 0.7 2.9 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.7 KOO30466.1 - 0.0041 16.7 0.2 0.077 12.6 0.2 2.8 2 1 0 2 2 2 1 NACHT domain AAA_22 PF13401.1 KOO30466.1 - 0.017 15.2 0.0 0.3 11.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 KOO30466.1 - 0.065 12.3 0.0 0.35 9.9 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin DUF2791 PF10923.3 KOO30466.1 - 0.12 10.9 0.0 0.38 9.3 0.0 1.7 2 0 0 2 2 2 0 P-loop Domain of unknown function (DUF2791) TPR_11 PF13414.1 KOO30466.1 - 0.13 11.9 2.5 0.19 11.3 0.2 2.5 2 0 0 2 2 2 0 TPR repeat DUF815 PF05673.8 KOO30466.1 - 0.24 10.2 0.0 0.43 9.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) zf-DHHC PF01529.15 KOO30467.1 - 6.8e-31 106.9 3.3 6.8e-31 106.9 2.3 1.9 2 1 0 2 2 2 1 DHHC palmitoyltransferase C1_1 PF00130.17 KOO30467.1 - 9.7 6.0 17.6 6.2 6.6 5.2 3.0 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF399 PF04187.8 KOO30469.1 - 4e-27 95.0 0.1 5.2e-27 94.7 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF399 Ank_2 PF12796.2 KOO30471.1 - 2.4e-47 159.2 2.2 7.8e-18 64.6 0.0 3.4 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO30471.1 - 1.7e-38 130.2 5.3 1.5e-11 44.4 0.0 4.2 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.25 KOO30471.1 - 6e-33 111.0 8.0 4.1e-07 29.4 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.1 KOO30471.1 - 4.9e-28 94.3 3.5 2.1e-06 27.4 0.0 5.5 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.1 KOO30471.1 - 2.7e-27 94.1 6.4 2.1e-09 37.3 0.0 4.7 2 1 3 5 5 5 4 Ankyrin repeats (many copies) NMT1_2 PF13379.1 KOO30471.1 - 0.041 13.2 0.3 0.46 9.8 0.0 2.0 1 1 1 2 2 2 0 NMT1-like family ketoacyl-synt PF00109.21 KOO30472.1 - 4e-57 193.5 0.0 1.1e-56 192.1 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.16 KOO30472.1 - 1.2e-53 182.5 0.0 2.9e-53 181.2 0.0 1.6 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.5 KOO30472.1 - 7.1e-47 159.3 1.3 6.7e-44 149.7 0.0 3.4 3 0 0 3 3 3 2 KR domain adh_short PF00106.20 KOO30472.1 - 4.2e-40 137.3 0.8 2.9e-37 128.1 0.0 3.8 3 0 0 3 3 3 1 short chain dehydrogenase NAD_binding_4 PF07993.7 KOO30472.1 - 3.5e-39 134.2 0.0 7.2e-39 133.2 0.0 1.5 1 0 0 1 1 1 1 Male sterility protein Ketoacyl-synt_C PF02801.17 KOO30472.1 - 6e-26 90.6 1.1 2.2e-25 88.8 0.7 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.1 KOO30472.1 - 2.6e-25 89.1 0.0 5.9e-25 88.0 0.0 1.6 1 0 0 1 1 1 1 Polyketide synthase dehydratase ADH_zinc_N PF00107.21 KOO30472.1 - 2.8e-21 75.4 2.0 1.1e-20 73.4 0.2 2.6 3 0 0 3 3 3 1 Zinc-binding dehydrogenase Sulfotransfer_3 PF13469.1 KOO30472.1 - 2.5e-11 44.7 5.7 2.5e-11 44.7 3.9 2.7 3 0 0 3 3 2 1 Sulfotransferase family Epimerase PF01370.16 KOO30472.1 - 1.8e-10 40.6 0.0 3e-07 30.1 0.0 3.0 3 0 0 3 3 3 2 NAD dependent epimerase/dehydratase family ADH_zinc_N_2 PF13602.1 KOO30472.1 - 3.8e-07 31.0 0.0 1.5e-06 29.1 0.0 2.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOO30472.1 - 4e-07 29.7 0.1 1e-06 28.4 0.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PP-binding PF00550.20 KOO30472.1 - 0.0051 17.0 0.0 0.012 15.8 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.14 KOO30472.1 - 0.061 12.0 0.0 0.64 8.6 0.0 2.1 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family Sulfotransfer_1 PF00685.22 KOO30472.1 - 0.27 10.4 0.0 0.49 9.5 0.0 1.4 1 0 0 1 1 1 0 Sulfotransferase domain Polysacc_synt_2 PF02719.10 KOO30472.1 - 0.4 9.5 0.0 22 3.7 0.0 2.3 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Piwi PF02171.12 KOO30473.1 - 1.9e-20 73.0 0.2 2.9e-20 72.4 0.1 1.3 1 0 0 1 1 1 1 Piwi domain NPV_P10 PF05531.7 KOO30474.1 - 0.033 14.4 6.4 2.4 8.4 1.1 3.9 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein RNA_polI_A14 PF08203.6 KOO30474.1 - 3.4 7.9 14.9 2.4 8.4 0.1 4.5 4 0 0 4 4 4 0 Yeast RNA polymerase I subunit RPA14 Pectate_lyase_3 PF12708.2 KOO30475.1 - 0.034 14.2 0.5 0.062 13.4 0.2 1.5 1 1 0 1 1 1 0 Pectate lyase superfamily protein tRNA-synt_1c PF00749.16 KOO30477.1 - 1.8e-88 296.2 0.0 1.8e-88 296.2 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 KOO30477.1 - 2.4e-26 92.4 0.0 7.6e-26 90.8 0.0 1.9 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain WHEP-TRS PF00458.15 KOO30477.1 - 6.2e-09 35.3 0.7 2.9e-08 33.2 0.5 2.2 1 0 0 1 1 1 1 WHEP-TRS domain GST_C_2 PF13410.1 KOO30477.1 - 0.0052 16.6 0.0 0.018 14.9 0.0 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 KOO30477.1 - 0.0053 16.7 0.0 0.041 13.8 0.0 2.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain DUF3021 PF11457.3 KOO30478.1 - 2.7 7.8 9.5 0.54 10.1 3.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3021) DUF3883 PF13020.1 KOO30479.1 - 0.07 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3883) JmjC PF02373.17 KOO30481.1 - 0.021 15.0 0.0 0.042 14.0 0.0 1.5 1 1 0 1 1 1 0 JmjC domain, hydroxylase TPR_MLP1_2 PF07926.7 KOO30483.1 - 0.00065 19.4 11.4 0.00065 19.4 7.9 10.8 4 2 3 8 8 8 2 TPR/MLP1/MLP2-like protein DUF4279 PF14106.1 KOO30483.1 - 0.23 11.3 5.4 0.96 9.3 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4279) DUF3994 PF13159.1 KOO30483.1 - 0.86 9.9 38.3 0.45 10.8 2.3 7.0 8 0 0 8 8 8 0 Domain of unknown function (DUF3994) DUF1059 PF06348.6 KOO30483.1 - 2.9 7.7 8.5 57 3.6 0.2 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1059) GlutR_dimer PF00745.15 KOO30484.1 - 0.1 12.5 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain SHOCT PF09851.4 KOO30484.1 - 1.1 8.8 4.0 0.68 9.4 0.6 2.3 2 1 0 2 2 2 0 Short C-terminal domain RVT_1 PF00078.22 KOO30485.1 - 1.4e-10 40.9 0.0 2.2e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mito_carr PF00153.22 KOO30486.1 - 1.1e-39 134.0 2.1 1.3e-14 53.6 0.2 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein ARL2_Bind_BART PF11527.3 KOO30486.1 - 4.3e-13 49.1 0.0 7.1e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART Pkinase PF00069.20 KOO30487.1 - 7.9e-63 212.0 0.1 1e-62 211.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO30487.1 - 3.7e-40 137.6 0.0 4.6e-40 137.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO30487.1 - 5e-08 32.2 0.0 1.1e-07 31.1 0.0 1.4 2 0 0 2 2 2 1 Kinase-like HIT PF01230.18 KOO30487.1 - 6e-06 26.7 0.0 1.2e-05 25.7 0.0 1.4 1 0 0 1 1 1 1 HIT domain CoA_binding PF02629.14 KOO30488.1 - 0.063 13.7 0.1 1.2 9.6 0.0 2.8 4 0 0 4 4 4 0 CoA binding domain DUF3613 PF12266.3 KOO30488.1 - 1.3 8.6 6.0 0.4 10.2 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3613) PH_8 PF15409.1 KOO30490.1 - 9e-10 38.4 2.8 0.0019 18.2 0.0 5.4 6 0 0 6 6 6 3 Pleckstrin homology domain PH_11 PF15413.1 KOO30490.1 - 7.4e-09 35.8 1.1 3.3e-05 24.1 0.1 3.9 3 0 0 3 3 3 2 Pleckstrin homology domain PH PF00169.24 KOO30490.1 - 2.2e-08 34.2 1.0 0.0014 18.7 0.0 5.1 5 1 0 5 5 5 2 PH domain PH_7 PF15408.1 KOO30490.1 - 0.00095 19.0 0.0 7.5 6.4 0.0 4.5 4 0 0 4 4 4 1 Pleckstrin homology domain Glycos_transf_2 PF00535.21 KOO30491.1 - 8.7e-12 45.0 0.0 1.5e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_7C PF02709.9 KOO30491.1 - 2.5e-11 42.8 0.0 4.5e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_3 PF13641.1 KOO30491.1 - 7.9e-09 35.6 0.1 1.2e-08 35.0 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 KOO30491.1 - 1.6e-07 30.7 0.0 0.0001 21.5 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 GlcNAc PF11397.3 KOO30491.1 - 0.00073 18.7 0.0 0.00092 18.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase (GlcNAc) UcrQ PF02939.11 KOO30492.1 - 0.00016 21.4 0.1 0.00022 20.9 0.0 1.2 1 1 0 1 1 1 1 UcrQ family Peptidase_C2 PF00648.16 KOO30493.1 - 1.9e-66 224.1 0.1 2.8e-66 223.5 0.1 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease CIAPIN1 PF05093.8 KOO30496.1 - 0.27 11.3 1.9 0.34 11.0 1.3 1.1 1 0 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis OAD_gamma PF04277.8 KOO30496.1 - 3.7 7.9 5.5 4.8 7.6 3.8 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain IL12 PF03039.9 KOO30497.1 - 0.064 12.3 0.5 0.11 11.6 0.4 1.3 1 0 0 1 1 1 0 Interleukin-12 alpha subunit Chlam_PMP PF02415.12 KOO30498.1 - 0.00026 21.0 0.7 0.075 13.3 0.1 3.1 3 0 0 3 3 3 2 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat TPR_17 PF13431.1 KOO30498.1 - 0.0018 18.3 0.0 0.0076 16.3 0.0 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat LRR_6 PF13516.1 KOO30499.1 - 1.8e-06 27.4 1.4 0.031 14.3 0.1 4.0 3 0 0 3 3 3 2 Leucine Rich repeat LRR_4 PF12799.2 KOO30499.1 - 0.0037 16.8 0.6 3.2 7.4 0.0 2.9 2 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO30499.1 - 0.0081 15.8 0.5 4.3 7.1 0.0 3.3 3 0 0 3 3 3 2 Leucine rich repeat HEAT_2 PF13646.1 KOO30500.1 - 2.1e-22 79.1 25.7 1e-05 25.6 0.7 8.0 2 2 6 9 9 9 9 HEAT repeats HEAT PF02985.17 KOO30500.1 - 2.7e-15 55.0 20.9 0.35 11.0 0.0 11.0 11 0 0 11 11 11 5 HEAT repeat Adaptin_N PF01602.15 KOO30500.1 - 3.5e-08 32.2 8.4 0.0015 16.9 0.0 4.3 3 1 1 4 4 4 3 Adaptin N terminal region HEAT_EZ PF13513.1 KOO30500.1 - 1.5e-07 31.6 24.3 1.3 9.6 0.0 9.5 8 2 2 10 10 10 3 HEAT-like repeat Cnd1 PF12717.2 KOO30500.1 - 7.1e-05 22.7 6.7 2 8.2 0.1 6.6 4 2 3 7 7 7 1 non-SMC mitotic condensation complex subunit 1 Cnd3 PF12719.2 KOO30500.1 - 0.016 14.2 1.2 2.8 6.8 0.0 3.6 2 1 1 3 3 3 0 Nuclear condensing complex subunits, C-term domain HEAT_PBS PF03130.11 KOO30500.1 - 0.034 14.6 2.0 24 5.7 0.1 4.5 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat Glyco_transf_28 PF03033.15 KOO30500.1 - 0.043 13.5 0.8 0.26 11.0 0.1 2.6 2 0 0 2 2 2 0 Glycosyltransferase family 28 N-terminal domain Cohesin_HEAT PF12765.2 KOO30500.1 - 0.14 12.1 0.1 0.14 12.1 0.1 4.8 6 0 0 6 6 6 0 HEAT repeat associated with sister chromatid cohesion CLASP_N PF12348.3 KOO30500.1 - 0.39 10.0 7.2 1.7 7.9 0.1 4.6 5 2 1 6 6 6 0 CLASP N terminal Ion_trans_2 PF07885.11 KOO30501.1 - 1.7e-30 104.5 13.0 2e-16 59.4 4.6 2.3 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.26 KOO30501.1 - 5.1e-08 32.3 2.9 0.0043 16.3 0.1 2.4 2 0 0 2 2 2 2 Ion transport protein PDZ PF00595.19 KOO30502.1 - 6.3e-06 26.2 0.0 1.6e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) DUF2587 PF10759.4 KOO30502.1 - 4.2e-05 23.0 5.3 0.047 13.0 0.6 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF2587) Stimulus_sens_1 PF13756.1 KOO30502.1 - 0.0028 18.0 8.2 0.13 12.6 0.6 2.6 1 1 1 2 2 2 2 Stimulus-sensing domain PDZ_2 PF13180.1 KOO30502.1 - 0.024 14.5 0.0 0.071 13.0 0.0 1.9 1 0 0 1 1 1 0 PDZ domain IQ PF00612.22 KOO30502.1 - 0.049 13.2 11.6 0.9 9.3 0.6 3.4 3 0 0 3 3 3 0 IQ calmodulin-binding motif TetR_C_6 PF13977.1 KOO30502.1 - 0.082 12.9 7.8 2.2 8.3 0.8 3.3 1 1 2 3 3 3 0 Bacterial transcriptional repressor UPF0149 PF03695.8 KOO30502.1 - 0.12 12.2 0.3 13 5.5 0.1 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0149) DUF2786 PF10979.3 KOO30502.1 - 0.17 11.6 12.3 0.3 10.8 0.3 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2786) FlaG PF03646.10 KOO30502.1 - 0.26 11.4 6.2 5.9 7.0 0.4 3.0 1 1 2 3 3 3 0 FlaG protein AAA_13 PF13166.1 KOO30504.1 - 0.14 10.5 8.0 0.36 9.2 2.1 2.2 2 0 0 2 2 2 0 AAA domain HC2 PF07382.6 KOO30504.1 - 1.1 9.0 32.5 0.028 14.2 17.7 1.8 2 0 0 2 2 2 0 Histone H1-like nucleoprotein HC2 DUF3373 PF11853.3 KOO30504.1 - 1.7 7.0 7.2 0.99 7.8 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3373) Spc7 PF08317.6 KOO30504.1 - 8.8 4.8 10.2 0.59 8.7 0.2 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein EF-hand_1 PF00036.27 KOO30505.1 - 2e-27 92.3 4.4 4.5e-06 25.5 0.0 5.1 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO30505.1 - 1.6e-26 91.6 3.1 5.5e-06 25.9 0.0 6.0 3 2 2 5 5 5 5 EF-hand domain pair EF-hand_7 PF13499.1 KOO30505.1 - 5e-25 87.4 0.4 2.1e-10 40.5 0.1 3.9 3 1 0 3 3 3 2 EF-hand domain pair TPK_catalytic PF04263.11 KOO30505.1 - 5.4e-22 77.6 0.1 1.9e-15 56.4 0.0 2.8 3 0 0 3 3 3 2 Thiamin pyrophosphokinase, catalytic domain EF-hand_6 PF13405.1 KOO30505.1 - 1.3e-18 65.1 1.0 0.0014 18.3 0.1 5.8 6 1 1 7 7 6 4 EF-hand domain EF-hand_5 PF13202.1 KOO30505.1 - 1.5e-18 65.1 1.9 0.0015 17.8 0.0 5.3 4 1 1 5 5 5 4 EF hand TPK_B1_binding PF04265.9 KOO30505.1 - 2.2e-15 56.1 0.0 3.9e-15 55.3 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain RIIa PF02197.12 KOO30505.1 - 2.9e-12 45.8 0.7 6.1e-12 44.7 0.5 1.6 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit SPARC_Ca_bdg PF10591.4 KOO30505.1 - 1.6e-06 28.0 0.1 0.41 10.6 0.0 3.4 2 1 1 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO30505.1 - 1.7e-06 27.6 4.0 0.96 9.2 0.0 5.6 2 1 4 6 6 6 2 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO30505.1 - 0.0069 16.0 7.1 3 7.5 0.1 4.6 4 1 1 5 5 5 3 EF hand Nucleotid_trans PF03407.11 KOO30506.1 - 2.2e-06 27.6 0.0 4.4e-06 26.6 0.0 1.5 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Pkinase PF00069.20 KOO30508.1 - 4.9e-35 120.9 0.0 1.7e-34 119.1 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO30508.1 - 1.5e-10 40.6 0.0 2.7e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4407 PF14362.1 KOO30508.1 - 0.0011 17.9 10.6 0.16 10.8 0.2 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4407) EF-hand_7 PF13499.1 KOO30508.1 - 0.0048 16.9 1.0 0.014 15.5 0.6 2.0 1 1 0 1 1 1 1 EF-hand domain pair IL11 PF07400.6 KOO30508.1 - 0.012 15.0 0.4 0.033 13.7 0.0 1.8 2 0 0 2 2 2 0 Interleukin 11 EF-hand_1 PF00036.27 KOO30508.1 - 0.018 14.3 1.6 1.2 8.6 1.0 2.6 2 0 0 2 2 2 0 EF hand Cast PF10174.4 KOO30508.1 - 0.038 12.0 16.7 0.19 9.7 0.7 2.1 2 0 0 2 2 2 0 RIM-binding protein of the cytomatrix active zone TMF_TATA_bd PF12325.3 KOO30508.1 - 0.058 13.1 11.5 0.32 10.7 6.0 2.6 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding Ribosomal_60s PF00428.14 KOO30508.1 - 0.5 10.7 15.9 1.6 9.2 0.5 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein Tropomyosin_1 PF12718.2 KOO30508.1 - 0.77 9.5 16.9 0.52 10.1 0.2 2.5 2 0 0 2 2 2 0 Tropomyosin like Mnd1 PF03962.10 KOO30508.1 - 1.8 8.2 10.9 14 5.3 0.0 2.4 2 0 0 2 2 2 0 Mnd1 family OmpH PF03938.9 KOO30508.1 - 2.8 7.8 8.9 4 7.3 0.1 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) APG6 PF04111.7 KOO30508.1 - 8 5.4 12.4 3.7 6.4 4.7 2.1 2 0 0 2 2 2 0 Autophagy protein Apg6 BRCT PF00533.21 KOO30509.1 - 4.4e-06 26.7 0.0 0.061 13.4 0.0 2.4 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 KOO30509.1 - 0.00019 21.2 0.0 0.00093 19.0 0.0 2.2 2 0 0 2 2 2 1 twin BRCT domain SDA1 PF05285.7 KOO30509.1 - 0.21 10.8 12.7 0.28 10.4 8.8 1.1 1 0 0 1 1 1 0 SDA1 DUF572 PF04502.8 KOO30509.1 - 1 8.4 6.0 1.4 8.0 4.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Nop14 PF04147.7 KOO30509.1 - 5.2 4.8 13.1 7 4.4 9.1 1.1 1 0 0 1 1 1 0 Nop14-like family Daxx PF03344.10 KOO30509.1 - 7.8 4.8 11.2 11 4.3 7.8 1.2 1 0 0 1 1 1 0 Daxx Family Arm PF00514.18 KOO30510.1 - 7.2e-22 76.3 5.2 0.00015 21.4 0.1 6.3 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO30510.1 - 0.1 12.9 12.1 0.84 9.9 4.2 3.2 1 1 3 4 4 4 0 HEAT repeats Retinal PF15449.1 KOO30510.1 - 0.25 8.9 12.8 0.31 8.6 8.9 1.0 1 0 0 1 1 1 0 Retinal protein HEAT_EZ PF13513.1 KOO30510.1 - 5 7.7 12.1 0.47 11.0 1.8 3.6 3 2 0 3 3 3 0 HEAT-like repeat TPR_12 PF13424.1 KOO30511.1 - 3.8e-128 417.6 70.6 5.8e-17 61.3 0.8 9.1 1 1 11 12 12 12 11 Tetratricopeptide repeat TPR_10 PF13374.1 KOO30511.1 - 8.8e-107 346.4 60.7 2.8e-10 39.7 0.0 14.4 14 0 0 14 14 14 13 Tetratricopeptide repeat TPR_1 PF00515.23 KOO30511.1 - 9.5e-31 104.1 29.5 0.024 14.2 0.1 12.4 12 0 0 12 12 12 10 Tetratricopeptide repeat TPR_7 PF13176.1 KOO30511.1 - 9.2e-26 87.5 42.4 0.087 12.6 0.0 12.9 12 0 0 12 12 12 9 Tetratricopeptide repeat TPR_2 PF07719.12 KOO30511.1 - 7.7e-23 78.5 42.0 0.063 13.2 0.1 12.9 13 0 0 13 13 12 10 Tetratricopeptide repeat TPR_4 PF07721.9 KOO30511.1 - 2.7e-21 73.7 34.7 0.047 14.1 0.2 14.7 13 0 0 13 13 13 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO30511.1 - 9.7e-20 68.8 29.8 0.055 13.2 0.1 12.4 12 0 0 12 12 12 4 Tetratricopeptide repeat TPR_11 PF13414.1 KOO30511.1 - 1.8e-19 69.1 25.2 0.00039 19.9 0.2 8.6 4 3 6 10 10 10 8 TPR repeat TPR_17 PF13431.1 KOO30511.1 - 1.5e-18 65.4 15.9 0.47 10.7 0.0 12.1 12 0 0 12 12 12 5 Tetratricopeptide repeat TPR_3 PF07720.7 KOO30511.1 - 6.8e-18 64.0 1.0 0.57 10.0 0.0 10.8 12 0 0 12 12 12 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO30511.1 - 9.9e-16 57.9 49.4 0.0026 18.3 0.4 10.2 4 2 7 11 11 11 8 Tetratricopeptide repeat TPR_14 PF13428.1 KOO30511.1 - 1.7e-10 40.5 49.8 0.39 11.4 0.4 13.5 11 2 2 13 13 13 3 Tetratricopeptide repeat TPR_5 PF12688.2 KOO30511.1 - 1.4e-08 34.7 33.5 0.01 15.8 1.0 6.3 2 1 4 6 6 6 5 Tetratrico peptide repeat TPR_19 PF14559.1 KOO30511.1 - 8.6e-08 32.4 41.1 0.19 12.0 0.5 8.8 4 2 6 10 10 10 5 Tetratricopeptide repeat Sec16_C PF12931.2 KOO30511.1 - 0.00052 19.8 4.9 23 4.6 0.0 6.5 3 2 1 5 5 5 0 Sec23-binding domain of Sec16 Nebulin PF00880.13 KOO30511.1 - 0.0081 15.7 0.0 1.3e+02 2.4 0.0 4.7 5 0 0 5 5 5 0 Nebulin repeat TPR_20 PF14561.1 KOO30511.1 - 0.024 14.7 24.9 0.86 9.7 0.1 7.0 1 1 6 9 9 9 0 Tetratricopeptide repeat Osmo_CC PF08946.5 KOO30511.1 - 0.073 13.1 10.3 39 4.3 0.0 8.0 9 0 0 9 9 8 0 Osmosensory transporter coiled coil FYRN PF05964.9 KOO30511.1 - 0.094 12.1 0.0 1.6e+02 1.8 0.0 4.5 5 0 0 5 5 5 0 F/Y-rich N-terminus Toxin_65 PF15543.1 KOO30511.1 - 0.26 10.9 2.5 2.7 7.6 0.1 3.9 4 1 3 7 7 7 0 Putative toxin 65 OKR_DC_1 PF01276.15 KOO30511.1 - 5.6 5.3 5.7 1.3e+02 0.9 0.0 4.9 7 0 0 7 7 7 0 Orn/Lys/Arg decarboxylase, major domain Arm PF00514.18 KOO30512.1 - 1.4e-08 34.2 0.5 2.5e-05 23.9 0.0 2.8 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat Citrate_synt PF00285.16 KOO30513.1 - 5.6e-106 354.2 0.0 6.6e-106 354.0 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase HTH_Tnp_Tc5 PF03221.11 KOO30513.1 - 0.022 14.5 0.0 0.56 10.0 0.0 2.4 2 0 0 2 2 2 0 Tc5 transposase DNA-binding domain Filamin PF00630.14 KOO30514.1 - 1.8e-46 156.8 0.0 7.9e-13 48.8 0.0 7.1 6 1 0 6 6 6 6 Filamin/ABP280 repeat CAP_GLY PF01302.20 KOO30514.1 - 3e-15 55.6 1.5 7.4e-15 54.4 1.0 1.6 1 0 0 1 1 1 1 CAP-Gly domain Big_1 PF02369.11 KOO30514.1 - 1.5e-07 31.2 0.1 0.00055 19.7 0.2 4.0 3 0 0 3 3 3 1 Bacterial Ig-like domain (group 1) Neurexophilin PF06312.7 KOO30514.1 - 0.0044 16.2 0.0 0.14 11.3 0.0 2.2 2 0 0 2 2 2 1 Neurexophilin Big_3_4 PF13754.1 KOO30514.1 - 0.03 14.6 1.2 3.6 7.9 0.2 4.2 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 3) 2-Hacid_dh_C PF02826.14 KOO30515.1 - 1.5e-33 115.4 0.0 1.8e-19 69.5 0.0 2.2 1 1 1 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain XdhC_C PF13478.1 KOO30515.1 - 0.0087 16.3 0.0 0.016 15.5 0.0 1.4 1 0 0 1 1 1 1 XdhC Rossmann domain U-box PF04564.10 KOO30516.1 - 7e-12 45.1 0.0 1.5e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 U-box domain C1_3 PF07649.7 KOO30516.1 - 0.0017 18.3 6.3 0.0037 17.2 4.4 1.5 1 0 0 1 1 1 1 C1-like domain zf-Nse PF11789.3 KOO30516.1 - 0.0018 17.7 0.0 0.0038 16.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit C1_2 PF03107.11 KOO30516.1 - 0.02 15.0 3.1 0.035 14.2 2.2 1.4 1 0 0 1 1 1 0 C1 domain Corona_nucleoca PF00937.13 KOO30516.1 - 1.3 7.8 5.2 1 8.2 0.5 2.1 2 0 0 2 2 2 0 Coronavirus nucleocapsid protein LRR_5 PF13306.1 KOO30517.1 - 3.2e-105 346.9 2.8 8.5e-37 125.7 0.0 3.1 3 0 0 3 3 3 3 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO30517.1 - 4.9e-25 87.0 0.0 0.0036 17.0 0.0 8.8 3 3 5 9 9 9 6 Leucine rich repeat LRR_4 PF12799.2 KOO30517.1 - 1.6e-05 24.3 0.1 0.2 11.3 0.0 4.2 3 0 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO30517.1 - 5.1e-05 22.7 0.0 2.1 8.6 0.0 4.4 3 0 0 3 3 3 1 Leucine Rich Repeat ZZ PF00569.12 KOO30517.1 - 9.1e-05 21.9 0.0 0.00022 20.7 0.0 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type LRR_7 PF13504.1 KOO30517.1 - 0.003 17.4 0.2 19 6.0 0.0 4.0 3 0 0 3 3 3 0 Leucine rich repeat MT PF12777.2 KOO30517.1 - 0.004 15.9 0.0 0.68 8.6 0.0 2.9 3 0 0 3 3 3 1 Microtubule-binding stalk of dynein motor RNA_pol_Rbc25 PF08292.7 KOO30517.1 - 0.013 15.7 0.0 34 4.6 0.0 3.3 3 0 0 3 3 3 0 RNA polymerase III subunit Rpc25 ZF-HD_dimer PF04770.7 KOO30517.1 - 0.043 13.8 3.4 1.4 9.0 0.0 4.1 4 1 1 5 5 5 0 ZF-HD protein dimerisation region MitoNEET_N PF10660.4 KOO30517.1 - 0.21 11.4 0.9 29 4.6 0.0 4.1 5 0 0 5 5 5 0 Iron-containing outer mitochondrial membrane protein N-terminus LRR_5 PF13306.1 KOO30519.1 - 9.6e-25 86.7 0.0 1.5e-24 86.1 0.0 1.2 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO30519.1 - 0.0079 15.9 0.0 0.5 10.1 0.0 2.9 1 1 1 2 2 2 1 Leucine rich repeat Dpy-30 PF05186.8 KOO30519.1 - 0.019 14.4 0.0 0.034 13.6 0.0 1.4 1 0 0 1 1 1 0 Dpy-30 motif Zip PF02535.17 KOO30520.1 - 2.2e-17 63.0 21.2 2.2e-10 40.0 4.7 2.7 2 1 1 3 3 3 2 ZIP Zinc transporter AtpR PF12966.2 KOO30520.1 - 2 8.5 8.5 1.9 8.6 0.8 3.2 2 1 1 3 3 3 0 N-ATPase, AtpR subunit REV PF00424.13 KOO30522.1 - 1.8 8.4 4.8 12 5.8 0.5 2.2 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) Glyco_hydro_20b PF02838.10 KOO30523.1 - 0.028 14.9 0.1 0.033 14.7 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 DUF3752 PF12572.3 KOO30523.1 - 0.27 11.3 2.2 0.35 10.9 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3752) CDK2AP PF09806.4 KOO30523.1 - 2.3 8.4 7.8 2.6 8.2 5.4 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein NUDIX-like PF09296.6 KOO30524.1 - 0.52 10.7 9.0 1.7 9.0 0.9 2.4 1 1 1 2 2 2 0 NADH pyrophosphatase-like rudimentary NUDIX domain LRR_5 PF13306.1 KOO30525.1 - 1.1e-100 332.3 0.0 3.9e-39 133.2 0.1 3.5 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) Adenylsucc_synt PF00709.16 KOO30525.1 - 1.6e-84 284.0 0.0 2.2e-84 283.5 0.0 1.2 1 0 0 1 1 1 1 Adenylosuccinate synthetase LRR_8 PF13855.1 KOO30525.1 - 4.1e-27 93.7 0.0 0.00012 21.7 0.0 6.9 2 1 5 7 7 7 6 Leucine rich repeat SAF PF08666.7 KOO30528.1 - 0.0038 17.5 0.0 1.4 9.3 0.0 2.3 2 0 0 2 2 2 2 SAF domain DUF1317 PF07026.6 KOO30528.1 - 0.034 14.0 0.2 18 5.2 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1317) RmlD_sub_bind PF04321.12 KOO30528.1 - 0.036 12.9 0.0 0.19 10.5 0.0 1.8 2 0 0 2 2 2 0 RmlD substrate binding domain Rod_cone_degen PF15201.1 KOO30528.1 - 0.052 13.3 0.0 12 5.8 0.0 2.4 2 0 0 2 2 2 0 Progressive rod-cone degeneration Pentapeptide PF00805.17 KOO30528.1 - 0.43 9.8 2.2 12 5.2 0.1 2.6 2 0 0 2 2 2 0 Pentapeptide repeats (8 copies) Pkinase PF00069.20 KOO30530.1 - 1.2e-61 208.1 0.0 1.5e-61 207.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO30530.1 - 9.8e-32 110.0 0.0 1.1e-31 109.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO30530.1 - 0.078 11.9 0.0 0.16 10.9 0.0 1.7 1 1 0 1 1 1 0 Kinase-like APH PF01636.18 KOO30530.1 - 0.087 12.5 0.2 0.49 10.0 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 KOO30530.1 - 0.089 11.8 0.1 0.15 11.0 0.0 1.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family gag-asp_proteas PF13975.1 KOO30531.1 - 1.3e-13 50.5 2.5 3.6e-08 33.1 0.1 2.5 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.1 KOO30531.1 - 2.7e-11 43.8 4.2 1.9e-06 28.2 0.4 2.6 2 1 0 2 2 2 2 Aspartyl protease RVP PF00077.15 KOO30531.1 - 1.3e-05 25.0 0.2 0.0081 16.0 0.0 2.5 2 0 0 2 2 2 2 Retroviral aspartyl protease Asp_protease PF09668.5 KOO30531.1 - 0.0062 16.0 0.1 0.044 13.3 0.0 2.2 2 0 0 2 2 2 1 Aspartyl protease APG9 PF04109.11 KOO30532.1 - 3.3e-104 348.7 0.0 4.5e-104 348.2 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein Apg9 RRM_1 PF00076.17 KOO30533.1 - 2.9e-14 52.4 0.0 3.9e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO30533.1 - 5e-10 39.0 0.0 7.4e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO30533.1 - 3.9e-09 36.3 0.0 5.6e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) TPR_11 PF13414.1 KOO30535.1 - 4.7e-16 58.1 8.7 1.3e-12 47.1 1.3 3.2 1 1 1 2 2 2 2 TPR repeat Arm PF00514.18 KOO30535.1 - 3.4e-13 48.8 20.0 0.018 14.8 0.0 8.8 9 0 0 9 9 9 5 Armadillo/beta-catenin-like repeat TPR_1 PF00515.23 KOO30535.1 - 1.6e-12 46.4 5.0 4.9e-05 22.7 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO30535.1 - 2.8e-07 29.9 17.2 0.0061 16.3 0.1 4.3 4 0 0 4 4 3 3 Tetratricopeptide repeat HEAT_2 PF13646.1 KOO30535.1 - 2e-05 24.7 40.2 0.011 16.0 0.0 8.4 4 2 3 8 8 8 4 HEAT repeats TPR_16 PF13432.1 KOO30535.1 - 0.0015 19.1 0.7 0.0015 19.1 0.5 6.1 5 2 1 6 6 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO30535.1 - 0.0023 18.0 3.4 0.4 10.9 0.4 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat HEAT PF02985.17 KOO30535.1 - 0.0043 17.0 11.6 0.76 10.0 0.0 6.4 6 0 0 6 6 6 2 HEAT repeat Fis1_TPR_C PF14853.1 KOO30535.1 - 0.018 14.9 4.0 0.041 13.7 0.4 2.9 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Proteasom_PSMB PF10508.4 KOO30535.1 - 0.054 11.7 1.4 2.8 6.1 0.0 2.7 3 0 0 3 3 3 0 Proteasome non-ATPase 26S subunit TPR_12 PF13424.1 KOO30535.1 - 0.094 12.6 9.7 0.19 11.7 1.2 4.1 3 1 0 3 3 3 0 Tetratricopeptide repeat Adaptin_N PF01602.15 KOO30535.1 - 0.15 10.3 1.0 3 6.0 0.1 3.0 3 1 0 3 3 3 0 Adaptin N terminal region TPR_8 PF13181.1 KOO30535.1 - 0.21 11.4 4.3 0.36 10.7 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat 2OG-FeII_Oxy_3 PF13640.1 KOO30536.1 - 6.3e-16 58.7 0.0 2e-15 57.1 0.0 1.8 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO30536.1 - 0.062 12.9 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Myc_N PF01056.13 KOO30536.1 - 0.19 10.8 3.6 0.29 10.2 2.5 1.3 1 0 0 1 1 1 0 Myc amino-terminal region DASH_Dad4 PF08650.5 KOO30537.1 - 0.18 11.7 0.3 13 5.7 0.1 2.4 2 0 0 2 2 2 0 DASH complex subunit Dad4 THF_DHG_CYH PF00763.18 KOO30538.1 - 2.2e-20 72.8 0.0 3.3e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.14 KOO30538.1 - 0.016 14.2 0.0 0.41 9.6 0.0 2.4 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain PDZ PF00595.19 KOO30540.1 - 1.7e-09 37.7 0.0 9.3e-05 22.5 0.0 3.0 2 1 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO30540.1 - 1.7e-07 31.0 0.0 0.0081 16.0 0.0 2.8 2 1 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.1 KOO30540.1 - 0.028 14.1 0.0 0.96 9.2 0.0 2.8 2 0 0 2 2 2 0 Tricorn protease PDZ domain AAA_13 PF13166.1 KOO30540.1 - 3 6.2 22.1 4.1 5.7 15.3 1.2 1 0 0 1 1 1 0 AAA domain Frag1 PF10277.4 KOO30541.1 - 6.6e-15 55.1 19.1 2.2e-13 50.2 2.1 2.4 2 0 0 2 2 2 2 Frag1/DRAM/Sfk1 family DUF998 PF06197.8 KOO30541.1 - 4.3e-08 32.6 35.8 1.9e-05 24.0 10.1 3.2 2 1 0 2 2 2 2 Protein of unknown function (DUF998) PrmA PF06325.8 KOO30542.1 - 4.7e-10 39.0 0.0 6.8e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.2 KOO30542.1 - 4.8e-09 36.7 0.0 9.4e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO30542.1 - 9e-08 32.1 0.2 3.1e-06 27.2 0.0 2.4 1 1 1 2 2 2 1 Methyltransferase domain Met_10 PF02475.11 KOO30542.1 - 9.1e-07 28.6 0.0 1.3e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Met-10+ like-protein PCMT PF01135.14 KOO30542.1 - 3.5e-05 23.4 0.0 5.7e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 KOO30542.1 - 5.6e-05 22.7 0.0 0.00011 21.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.10 KOO30542.1 - 0.0001 21.7 0.0 0.00017 21.0 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 RrnaAD PF00398.15 KOO30542.1 - 0.00047 19.2 0.0 0.00065 18.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase MTS PF05175.9 KOO30542.1 - 0.00069 19.0 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_3 PF01596.12 KOO30542.1 - 0.00081 18.4 0.0 0.0013 17.7 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_23 PF13489.1 KOO30542.1 - 0.0011 18.6 0.0 0.0021 17.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 KOO30542.1 - 0.0037 16.9 0.0 0.0077 15.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.1 KOO30542.1 - 0.035 14.9 0.1 0.34 11.7 0.0 2.2 1 1 1 2 2 2 0 Methyltransferase domain PRMT5 PF05185.11 KOO30542.1 - 0.047 12.5 0.0 0.059 12.2 0.0 1.1 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Methyltransf_16 PF10294.4 KOO30542.1 - 0.057 12.8 0.0 0.094 12.1 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_4 PF02390.12 KOO30542.1 - 0.096 11.7 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase LRR_6 PF13516.1 KOO30543.1 - 9.2e-09 34.4 0.5 0.0079 16.1 0.0 4.1 3 0 0 3 3 3 2 Leucine Rich repeat ResIII PF04851.10 KOO30543.1 - 0.00019 21.3 0.0 0.0053 16.6 0.0 2.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.11 KOO30543.1 - 0.00066 18.9 0.0 0.0014 17.9 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein AAA_19 PF13245.1 KOO30543.1 - 0.0051 16.5 0.0 0.026 14.2 0.0 2.4 1 0 0 1 1 1 1 Part of AAA domain UvrD_C_2 PF13538.1 KOO30543.1 - 0.014 15.5 0.0 0.058 13.5 0.0 2.2 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain LRR_4 PF12799.2 KOO30543.1 - 0.023 14.3 0.0 3.4 7.3 0.0 2.7 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) AAA_25 PF13481.1 KOO30543.1 - 0.027 13.8 3.1 0.5 9.7 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.1 KOO30543.1 - 0.034 14.2 0.1 0.58 10.3 0.0 3.0 3 0 0 3 3 3 0 AAA domain Mod_r PF07200.8 KOO30543.1 - 0.058 13.3 0.2 0.058 13.3 0.1 2.0 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein RVT_1 PF00078.22 KOO30544.1 - 8.5e-10 38.3 0.0 1.6e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.9 KOO30544.1 - 0.25 10.2 0.0 0.54 9.1 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) LRR_6 PF13516.1 KOO30545.1 - 0.0039 17.1 0.3 0.026 14.5 0.0 2.2 2 0 0 2 2 2 1 Leucine Rich repeat zf-CCHC PF00098.18 KOO30546.1 - 0.0043 16.9 0.2 0.0089 15.9 0.1 1.6 1 0 0 1 1 1 1 Zinc knuckle TruB_N PF01509.13 KOO30549.1 - 0.13 12.3 0.1 0.33 11.0 0.0 1.6 2 0 0 2 2 2 0 TruB family pseudouridylate synthase (N terminal domain) Pkinase PF00069.20 KOO30551.1 - 5.7e-43 146.9 0.0 9.9e-43 146.1 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO30551.1 - 3.3e-21 75.5 0.0 4.7e-21 75.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase NTP_transf_3 PF12804.2 KOO30551.1 - 1.2e-07 31.9 0.1 3.2e-07 30.5 0.1 1.7 1 0 0 1 1 1 1 MobA-like NTP transferase domain Kinase-like PF14531.1 KOO30551.1 - 3e-06 26.3 0.0 4.5e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like NTP_transferase PF00483.18 KOO30551.1 - 0.013 14.8 0.0 0.021 14.1 0.0 1.2 1 0 0 1 1 1 0 Nucleotidyl transferase APH PF01636.18 KOO30551.1 - 0.014 15.1 3.5 0.098 12.3 0.4 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family Peptidase_M16 PF00675.15 KOO30552.1 - 1.6e-31 109.1 0.0 2.5e-31 108.4 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Abhydrolase_2 PF02230.11 KOO30554.1 - 9.2e-51 172.3 0.0 1.1e-50 172.0 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 KOO30554.1 - 3.5e-16 59.2 0.0 4.6e-16 58.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO30554.1 - 3.2e-13 50.0 0.3 5.8e-08 32.8 0.1 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 KOO30554.1 - 4.8e-09 35.7 0.2 1.1e-06 28.0 0.0 2.4 1 1 1 2 2 2 2 Prolyl oligopeptidase family FSH1 PF03959.8 KOO30554.1 - 3.7e-08 33.0 0.0 1e-07 31.6 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.13 KOO30554.1 - 4.5e-07 29.3 0.0 5.7e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.8 KOO30554.1 - 2.7e-05 23.8 0.1 0.11 12.0 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Esterase PF00756.15 KOO30554.1 - 9.8e-05 21.8 0.1 0.00089 18.7 0.0 2.0 2 0 0 2 2 2 1 Putative esterase Esterase_phd PF10503.4 KOO30554.1 - 0.00015 21.1 0.3 0.015 14.5 0.0 2.3 2 1 1 3 3 3 1 Esterase PHB depolymerase Lipase_3 PF01764.20 KOO30554.1 - 0.0014 18.2 0.0 0.0018 17.8 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) BAAT_C PF08840.6 KOO30554.1 - 0.004 16.9 0.2 0.45 10.1 0.1 2.1 1 1 1 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal DUF2974 PF11187.3 KOO30554.1 - 0.0055 16.0 0.0 0.0073 15.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Cutinase PF01083.17 KOO30554.1 - 0.007 16.1 0.0 0.0094 15.6 0.0 1.3 1 0 0 1 1 1 1 Cutinase Abhydrolase_1 PF00561.15 KOO30554.1 - 0.016 14.7 0.1 0.036 13.6 0.1 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold DUF2048 PF09752.4 KOO30554.1 - 0.017 13.9 0.0 0.024 13.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2048) DUF829 PF05705.9 KOO30554.1 - 0.027 14.1 0.0 0.43 10.2 0.0 2.0 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF829) LIP PF03583.9 KOO30554.1 - 0.032 13.4 0.0 0.22 10.6 0.0 1.9 2 0 0 2 2 2 0 Secretory lipase EF-hand_7 PF13499.1 KOO30555.1 - 2.5e-13 49.9 0.0 9.6e-09 35.2 0.0 2.8 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO30555.1 - 4e-13 48.0 0.1 2e-07 30.2 0.0 4.1 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.27 KOO30555.1 - 5.1e-13 47.3 0.1 7.8e-08 31.0 0.0 3.9 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.1 KOO30555.1 - 2.5e-12 46.1 1.4 0.002 17.7 0.0 4.0 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.1 KOO30555.1 - 6e-09 35.7 0.0 3.7e-08 33.1 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.1 KOO30555.1 - 5.4e-06 25.5 0.1 0.00014 21.0 0.0 2.9 4 0 0 4 4 4 1 EF hand DUF4449 PF14613.1 KOO30556.1 - 2.6 7.9 13.6 2.6 7.9 8.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4449) PH PF00169.24 KOO30558.1 - 4.6e-05 23.5 0.0 0.00021 21.4 0.0 2.1 2 1 0 2 2 2 1 PH domain PH_8 PF15409.1 KOO30558.1 - 0.11 12.5 0.0 27 4.9 0.0 2.7 2 0 0 2 2 2 0 Pleckstrin homology domain ETRAMP PF09716.5 KOO30558.1 - 0.46 10.4 2.2 0.79 9.7 0.1 2.3 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) PGPGW PF09656.5 KOO30559.1 - 0.071 12.4 1.1 0.12 11.6 0.1 1.9 2 0 0 2 2 2 0 Putative transmembrane protein (PGPGW) DUF973 PF06157.6 KOO30560.1 - 0.08 11.8 2.5 0.19 10.6 0.3 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF973) MerC PF03203.9 KOO30560.1 - 0.88 9.9 11.1 0.19 12.0 2.1 2.6 1 1 2 3 3 3 0 MerC mercury resistance protein DUF872 PF05915.7 KOO30560.1 - 4.9 7.0 4.9 1.1 9.0 0.3 2.2 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) DUF2854 PF11016.3 KOO30561.1 - 0.033 13.7 0.7 0.092 12.2 0.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2854) DUF1439 PF07273.7 KOO30561.1 - 0.062 13.0 0.1 0.14 11.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1439) NPV_P10 PF05531.7 KOO30561.1 - 0.87 9.8 2.7 28 5.0 0.1 3.0 2 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein AlkA_N PF06029.6 KOO30561.1 - 4.4 7.4 6.3 57 3.7 0.1 2.9 1 1 1 2 2 2 0 AlkA N-terminal domain HD PF01966.17 KOO30562.1 - 4.7e-08 33.0 0.0 1.3e-07 31.7 0.0 1.8 1 0 0 1 1 1 1 HD domain PhyH PF05721.8 KOO30562.1 - 5.4e-06 26.5 0.0 9.3e-05 22.5 0.0 2.2 1 1 1 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.1 KOO30562.1 - 0.0013 18.9 0.0 0.0037 17.5 0.0 1.8 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase Mpv17_PMP22 PF04117.7 KOO30563.1 - 8.1e-18 63.8 0.9 1e-17 63.4 0.4 1.3 1 1 0 1 1 1 1 Mpv17 / PMP22 family zf-CCHC_2 PF13696.1 KOO30564.1 - 0.00054 19.4 2.1 0.00054 19.4 1.4 2.5 1 1 1 2 2 2 1 Zinc knuckle zf-CCHC PF00098.18 KOO30564.1 - 0.0013 18.5 3.4 0.0013 18.5 2.3 2.9 2 1 0 2 2 2 1 Zinc knuckle GLTP PF08718.6 KOO30565.1 - 6.5e-11 42.4 0.0 1.1e-10 41.7 0.0 1.3 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) Lectin_C PF00059.16 KOO30568.1 - 4.3e-07 30.5 0.5 1.2e-06 29.0 0.3 1.9 1 0 0 1 1 1 1 Lectin C-type domain Herpes_UL45 PF05473.7 KOO30568.1 - 0.00012 21.6 0.2 0.019 14.3 0.1 2.5 2 0 0 2 2 2 2 UL45 protein WW PF00397.21 KOO30568.1 - 0.042 13.7 3.8 0.037 13.8 0.5 2.3 2 0 0 2 2 2 0 WW domain Ank_2 PF12796.2 KOO30569.1 - 1.2e-29 102.5 0.8 4.6e-15 55.7 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO30569.1 - 3.3e-12 45.5 0.1 2.4e-05 23.8 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 KOO30569.1 - 5.8e-12 45.4 0.5 4.1e-07 30.0 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO30569.1 - 9.6e-09 35.5 0.1 1.2e-07 32.0 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO30569.1 - 1.2e-08 34.3 0.0 0.00033 20.5 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ion_trans PF00520.26 KOO30569.1 - 0.00018 20.8 0.2 0.00038 19.7 0.2 1.6 1 0 0 1 1 1 1 Ion transport protein GvpK PF05121.7 KOO30569.1 - 0.72 9.7 7.2 1.7 8.4 5.0 1.6 1 0 0 1 1 1 0 Gas vesicle protein K LRR_6 PF13516.1 KOO30570.1 - 1.3e-13 49.4 4.0 0.018 15.0 0.1 5.9 5 0 0 5 5 5 4 Leucine Rich repeat NACHT PF05729.7 KOO30570.1 - 3.2e-05 23.6 0.4 0.00012 21.8 0.0 2.1 2 0 0 2 2 2 1 NACHT domain RRM_1 PF00076.17 KOO30570.1 - 0.052 13.1 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HBS1_N PF08938.5 KOO30570.1 - 0.26 11.4 0.7 0.94 9.6 0.5 1.9 1 0 0 1 1 1 0 HBS1 N-terminus CENP-U PF13097.1 KOO30571.1 - 0.056 13.3 0.2 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit ABC1 PF03109.11 KOO30572.1 - 1.7e-20 73.1 0.0 3e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 KOO30572.1 - 8.5e-05 22.4 2.6 8.5e-05 22.4 1.8 3.9 2 2 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.20 KOO30572.1 - 0.012 14.8 0.0 0.058 12.5 0.0 1.9 2 0 0 2 2 2 0 Protein kinase domain TPR_2 PF07719.12 KOO30573.1 - 2.8e-05 23.6 2.0 0.015 15.1 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO30573.1 - 0.00044 19.8 0.6 0.0011 18.6 0.4 1.7 1 1 0 1 1 1 1 TPR repeat TPR_16 PF13432.1 KOO30573.1 - 0.00069 20.2 0.8 0.00069 20.2 0.6 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO30573.1 - 0.0018 17.8 1.4 0.016 14.7 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO30573.1 - 0.027 14.2 0.0 1.8 8.5 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_5 PF12688.2 KOO30573.1 - 0.031 14.3 0.1 0.066 13.2 0.0 1.6 1 0 0 1 1 1 0 Tetratrico peptide repeat Apc3 PF12895.2 KOO30573.1 - 0.093 12.8 0.1 0.27 11.4 0.1 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 KOO30573.1 - 0.14 12.7 0.7 37 5.0 0.0 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO30573.1 - 0.23 12.2 4.8 4.8 8.0 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Glyco_transf_11 PF01531.11 KOO30575.1 - 0.14 11.1 0.4 0.92 8.4 0.2 2.1 1 1 0 1 1 1 0 Glycosyl transferase family 11 ANAPC15 PF15243.1 KOO30576.1 - 2.8e-08 33.7 6.8 4.7e-08 32.9 4.7 1.4 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 15 Adeno_terminal PF02459.10 KOO30576.1 - 0.15 10.1 0.0 0.14 10.2 0.0 1.0 1 0 0 1 1 1 0 Adenoviral DNA terminal protein Nucleoplasmin PF03066.10 KOO30576.1 - 1.6 8.2 10.6 1.9 7.9 7.3 1.4 1 0 0 1 1 1 0 Nucleoplasmin PBP1_TM PF14812.1 KOO30576.1 - 3 8.1 9.7 5.2 7.4 6.7 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.7 KOO30576.1 - 3.8 6.6 8.3 4.1 6.5 5.8 1.1 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.7 KOO30576.1 - 6.2 4.6 13.7 6 4.6 9.5 1.0 1 0 0 1 1 1 0 Nop14-like family Trypan_PARP PF05887.6 KOO30576.1 - 9.2 6.0 13.7 11 5.8 9.5 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) NeA_P2 PF12312.3 KOO30578.1 - 0.062 12.5 0.2 0.1 11.8 0.1 1.3 1 0 0 1 1 1 0 Nepovirus subgroup A polyprotein Transglut_C PF00927.17 KOO30578.1 - 0.082 12.9 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 Transglutaminase family, C-terminal ig like domain Myosin_head PF00063.16 KOO30579.1 - 2.5e-90 303.4 0.0 1.4e-53 182.0 0.0 2.6 2 1 1 3 3 3 2 Myosin head (motor domain) AAA_30 PF13604.1 KOO30579.1 - 0.008 15.7 0.4 0.018 14.6 0.3 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOO30579.1 - 0.019 14.9 1.9 0.11 12.4 0.5 2.8 2 1 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.7 KOO30579.1 - 0.025 13.6 0.1 0.049 12.7 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Sigma54_activat PF00158.21 KOO30579.1 - 0.097 12.1 0.1 1 8.8 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain DJ-1_PfpI PF01965.19 KOO30580.1 - 2.7e-33 114.4 0.5 3.5e-33 114.1 0.4 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family DUF4066 PF13278.1 KOO30580.1 - 1.8e-16 59.8 0.1 2.1e-16 59.6 0.0 1.0 1 0 0 1 1 1 1 Putative amidotransferase Imm-NTF2 PF15655.1 KOO30581.1 - 0.013 15.9 0.8 0.013 15.9 0.6 2.3 2 1 0 2 2 2 0 NTF2 fold immunity protein Bul1_N PF04425.7 KOO30581.1 - 0.46 8.9 5.3 0.82 8.1 3.7 1.5 1 0 0 1 1 1 0 Bul1 N terminus 2OG-FeII_Oxy PF03171.15 KOO30582.1 - 9.5e-05 22.6 0.0 0.00021 21.5 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily adh_short PF00106.20 KOO30583.1 - 2.3e-30 105.7 4.7 2.3e-30 105.7 3.2 1.5 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 KOO30583.1 - 6.7e-18 64.9 1.6 1.2e-17 64.1 1.1 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 KOO30583.1 - 3.9e-10 39.9 0.1 6.1e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 KOO30583.1 - 2.3e-08 34.2 0.4 6.5e-08 32.7 0.3 1.7 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 KOO30583.1 - 1.4e-05 24.6 0.2 2.1e-05 24.0 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 KOO30583.1 - 0.0017 17.1 0.1 0.0027 16.4 0.1 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.14 KOO30583.1 - 0.0042 16.1 0.0 0.0084 15.1 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_7 PF13241.1 KOO30583.1 - 0.0069 16.6 0.1 0.012 15.8 0.0 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding Eno-Rase_NADH_b PF12242.3 KOO30583.1 - 0.017 14.8 0.5 0.049 13.4 0.0 2.0 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase ApbA PF02558.11 KOO30583.1 - 0.026 13.9 0.1 0.041 13.3 0.1 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Polysacc_synt_2 PF02719.10 KOO30583.1 - 0.027 13.3 0.0 0.035 13.0 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein NmrA PF05368.8 KOO30583.1 - 0.045 13.0 0.3 0.071 12.3 0.2 1.3 1 0 0 1 1 1 0 NmrA-like family F420_oxidored PF03807.12 KOO30583.1 - 0.059 13.7 0.1 0.12 12.8 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DFP PF04127.10 KOO30583.1 - 0.093 12.3 0.5 0.16 11.6 0.3 1.5 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Glyco_tran_WecB PF03808.8 KOO30583.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family BBIP10 PF14777.1 KOO30586.1 - 6e-19 67.1 0.2 6.4e-19 67.0 0.1 1.1 1 0 0 1 1 1 1 Cilia BBSome complex subunit 10 FYVE PF01363.16 KOO30587.1 - 7e-16 57.8 1.1 2.4e-15 56.1 0.5 2.1 2 0 0 2 2 2 1 FYVE zinc finger FYVE_2 PF02318.11 KOO30587.1 - 0.019 14.8 1.3 0.048 13.5 0.9 1.6 1 0 0 1 1 1 0 FYVE-type zinc finger TPR_12 PF13424.1 KOO30588.1 - 1.3e-47 159.6 17.8 1.1e-16 60.4 0.1 4.1 1 1 2 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.1 KOO30588.1 - 5.6e-47 156.4 27.5 1.3e-09 37.6 0.1 6.1 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_1 PF00515.23 KOO30588.1 - 4.4e-18 64.0 3.9 0.0012 18.3 0.4 5.6 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_4 PF07721.9 KOO30588.1 - 8.7e-17 59.7 33.4 0.013 15.9 0.1 6.7 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.12 KOO30588.1 - 1.4e-15 55.8 11.6 0.0069 16.2 0.6 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.1 KOO30588.1 - 8.6e-14 50.5 4.8 0.22 11.8 0.0 6.5 6 1 0 6 6 6 5 Tetratricopeptide repeat TPR_16 PF13432.1 KOO30588.1 - 1.9e-12 47.4 20.7 9.3e-05 22.9 0.2 5.1 1 1 4 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.1 KOO30588.1 - 1.9e-10 39.7 2.7 0.047 13.4 0.1 5.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOO30588.1 - 1.3e-09 37.8 26.6 0.12 13.0 0.7 6.2 4 1 2 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.1 KOO30588.1 - 2.5e-09 36.6 6.1 0.00081 18.9 0.1 3.7 1 1 4 5 5 5 4 TPR repeat TPR_19 PF14559.1 KOO30588.1 - 7.9e-09 35.7 16.9 0.011 16.1 2.0 5.1 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_3 PF07720.7 KOO30588.1 - 6.7e-07 28.9 0.0 2 8.2 0.0 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO30588.1 - 7.8e-07 28.4 18.3 0.46 10.3 0.0 5.9 6 0 0 6 6 6 3 Tetratricopeptide repeat HisKA_3 PF07730.8 KOO30588.1 - 0.0022 18.2 14.1 0.41 11.0 0.1 5.2 4 2 1 5 5 5 1 Histidine kinase Sec16_C PF12931.2 KOO30588.1 - 0.02 14.6 0.9 26 4.4 0.0 3.7 1 1 3 4 4 4 0 Sec23-binding domain of Sec16 TPR_6 PF13174.1 KOO30588.1 - 0.053 14.0 14.4 13 6.5 0.3 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_21 PF09976.4 KOO30588.1 - 0.078 12.9 3.8 32 4.4 0.0 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat ApoLp-III PF07464.6 KOO30588.1 - 0.16 12.0 0.0 38 4.2 0.0 3.0 1 1 3 4 4 4 0 Apolipophorin-III precursor (apoLp-III) tRNA-synt_1 PF00133.17 KOO30589.1 - 2.3e-33 115.1 0.1 7.3e-10 37.4 0.0 4.2 4 0 0 4 4 4 4 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 KOO30589.1 - 4.1e-18 65.2 0.0 6.6e-09 34.9 0.0 3.2 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.8 KOO30589.1 - 2.2e-12 46.9 0.1 4.2e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA fn3 PF00041.16 KOO30589.1 - 6.5e-08 32.6 0.0 1.3e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain tRNA-synt_1e PF01406.14 KOO30589.1 - 2.3e-05 23.6 0.0 4.1e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.13 KOO30589.1 - 0.027 13.1 0.0 0.051 12.2 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (K) tRNA-synt_1b PF00579.20 KOO30589.1 - 0.078 12.0 0.0 0.28 10.2 0.0 1.9 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) PDZ PF00595.19 KOO30590.1 - 0.12 12.6 0.2 0.27 11.4 0.2 1.5 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) TerB-C PF15615.1 KOO30591.1 - 0.042 14.1 0.7 0.042 14.1 0.5 1.7 1 1 1 2 2 2 0 TerB-C domain Zip PF02535.17 KOO30591.1 - 0.048 12.6 13.5 0.055 12.4 9.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2922 PF11148.3 KOO30591.1 - 0.12 12.0 0.0 0.29 10.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2922) ARGLU PF15346.1 KOO30591.1 - 5.7 6.7 6.4 13 5.4 0.7 3.0 3 0 0 3 3 3 0 Arginine and glutamate-rich 1 AAA_16 PF13191.1 KOO30592.1 - 0.003 17.5 1.1 0.012 15.6 0.1 2.3 2 1 1 3 3 3 1 AAA ATPase domain AAA_19 PF13245.1 KOO30592.1 - 0.1 12.3 0.4 0.5 10.1 0.0 2.3 2 0 0 2 2 2 0 Part of AAA domain AAA_29 PF13555.1 KOO30592.1 - 0.12 11.9 0.0 0.32 10.5 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.10 KOO30592.1 - 0.17 10.5 0.0 0.29 9.7 0.0 1.3 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein LRR_6 PF13516.1 KOO30593.1 - 1.3e-35 117.4 1.9 0.0004 20.1 0.0 8.7 9 0 0 9 9 9 6 Leucine Rich repeat Skp1 PF01466.14 KOO30593.1 - 2.5e-05 24.2 0.0 7.6e-05 22.6 0.0 1.8 1 0 0 1 1 1 1 Skp1 family, dimerisation domain SpoU_sub_bind PF08032.7 KOO30593.1 - 5.9e-05 23.1 5.7 0.079 13.1 0.0 4.3 3 1 1 4 4 4 2 RNA 2'-O ribose methyltransferase substrate binding CbiG_N PF11760.3 KOO30593.1 - 0.01 15.4 17.3 0.57 9.9 0.1 5.6 3 1 3 6 6 6 0 Cobalamin synthesis G N-terminal Flu_M1 PF00598.14 KOO30593.1 - 0.16 11.3 1.9 3.2 7.1 0.1 3.2 1 1 3 4 4 4 0 Influenza Matrix protein (M1) SET PF00856.23 KOO30594.1 - 1.1e-06 29.0 0.0 5.4e-06 26.7 0.0 1.9 1 1 0 1 1 1 1 SET domain Spore_YunB PF09560.5 KOO30595.1 - 0.07 12.8 0.9 6.5 6.5 0.1 2.6 1 1 1 2 2 2 0 Sporulation protein YunB (Spo_YunB) SAM_2 PF07647.12 KOO30595.1 - 0.31 10.9 3.1 29 4.6 0.1 2.7 1 1 2 3 3 3 0 SAM domain (Sterile alpha motif) Fork_head_N PF08430.7 KOO30595.1 - 0.58 10.5 27.6 0.75 10.1 19.2 1.3 1 0 0 1 1 1 0 Forkhead N-terminal region RPAP1_N PF08621.5 KOO30595.1 - 0.77 9.3 4.1 6.7 6.3 1.2 2.4 1 1 0 2 2 2 0 RPAP1-like, N-terminal Snf7 PF03357.16 KOO30596.1 - 2.4e-21 75.8 10.6 3e-21 75.5 7.4 1.1 1 0 0 1 1 1 1 Snf7 Seryl_tRNA_N PF02403.17 KOO30596.1 - 0.0014 18.6 9.9 0.0083 16.1 3.3 2.3 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain Mnd1 PF03962.10 KOO30596.1 - 0.015 14.9 6.8 0.03 14.0 4.4 1.7 1 1 0 1 1 1 0 Mnd1 family RFXA_RFXANK_bdg PF15289.1 KOO30596.1 - 0.54 10.4 4.8 0.22 11.7 0.9 2.0 1 1 0 2 2 2 0 Regulatory factor X-associated C-terminal binding domain MSP1_C PF07462.6 KOO30596.1 - 0.59 8.4 5.3 0.25 9.6 2.2 1.5 1 1 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus LUC7 PF03194.10 KOO30596.1 - 0.69 9.3 7.5 0.71 9.3 4.7 1.3 1 1 0 1 1 1 0 LUC7 N_terminus DUF948 PF06103.6 KOO30596.1 - 0.76 9.6 6.5 1 9.2 0.6 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) TetR_C_6 PF13977.1 KOO30596.1 - 0.93 9.5 8.1 1.4 8.9 1.0 2.5 2 1 0 2 2 2 0 Bacterial transcriptional repressor Syntaxin-6_N PF09177.6 KOO30596.1 - 1.3 9.4 4.6 5.7 7.4 1.1 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DSBA PF01323.15 KOO30596.1 - 3.2 7.2 8.7 0.86 9.1 1.7 2.2 1 1 1 2 2 2 0 DSBA-like thioredoxin domain Cwf_Cwc_15 PF04889.7 KOO30596.1 - 3.9 7.1 11.0 4.1 7.0 3.9 2.1 1 1 1 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Armet PF10208.4 KOO30597.1 - 9.8e-32 109.7 3.8 1.2e-31 109.4 2.7 1.0 1 0 0 1 1 1 1 Degradation arginine-rich protein for mis-folding SAP PF02037.22 KOO30597.1 - 0.0012 18.3 0.0 0.003 17.0 0.0 1.7 1 0 0 1 1 1 1 SAP domain LRR_8 PF13855.1 KOO30598.1 - 2.6e-06 27.0 1.8 5.6e-06 26.0 0.2 2.1 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.2 KOO30598.1 - 0.0027 17.2 0.8 0.014 15.0 0.0 2.3 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO30598.1 - 0.012 15.6 0.0 0.76 10.0 0.0 3.5 3 0 0 3 3 3 0 Leucine Rich repeat LRR_1 PF00560.28 KOO30598.1 - 0.026 14.4 0.2 0.15 12.1 0.0 2.4 2 0 0 2 2 2 0 Leucine Rich Repeat PTPlike_phytase PF14566.1 KOO30599.1 - 2.3e-25 89.3 0.0 3.6e-25 88.7 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate TPR_11 PF13414.1 KOO30600.1 - 1.3e-05 24.7 9.8 0.00023 20.7 1.7 3.3 2 1 0 2 2 2 2 TPR repeat TPR_12 PF13424.1 KOO30600.1 - 0.0019 18.1 11.1 0.006 16.5 3.6 3.4 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO30600.1 - 0.0022 17.7 13.7 0.036 13.9 0.1 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO30600.1 - 0.05 13.4 0.1 4.9 7.1 0.0 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOO30600.1 - 0.052 13.1 6.9 0.96 9.1 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat PAT1 PF09770.4 KOO30601.1 - 0.013 13.8 0.0 0.013 13.8 0.0 2.0 1 1 1 2 2 2 0 Topoisomerase II-associated protein PAT1 SNARE PF05739.14 KOO30603.1 - 9.8e-15 53.9 2.8 9.8e-15 53.9 2.0 3.3 4 0 0 4 4 3 1 SNARE domain Syntaxin PF00804.20 KOO30603.1 - 4.9e-13 49.1 7.5 5e-13 49.0 2.7 2.3 2 0 0 2 2 2 1 Syntaxin DUF1518 PF07469.7 KOO30603.1 - 0.027 14.6 0.9 0.11 12.6 0.6 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1518) Baculo_PEP_C PF04513.7 KOO30603.1 - 0.029 14.2 9.1 0.25 11.1 0.5 3.0 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Atg14 PF10186.4 KOO30603.1 - 0.076 11.9 7.7 7.9 5.3 5.1 2.3 2 1 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Syntaxin-6_N PF09177.6 KOO30603.1 - 0.084 13.2 7.6 0.1 13.0 0.7 3.2 2 1 2 4 4 4 0 Syntaxin 6, N-terminal Vac_Fusion PF02346.11 KOO30603.1 - 0.11 11.9 0.2 10 5.6 0.0 2.8 2 0 0 2 2 2 0 Chordopoxvirus fusion protein Cluap1 PF10234.4 KOO30603.1 - 0.13 11.4 11.4 0.013 14.7 4.0 1.9 2 0 0 2 2 2 0 Clusterin-associated protein-1 EzrA PF06160.7 KOO30603.1 - 0.19 9.8 7.3 0.1 10.7 2.0 2.0 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA NPV_P10 PF05531.7 KOO30603.1 - 0.89 9.8 3.9 2.7 8.3 0.4 2.7 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.7 KOO30603.1 - 0.96 9.2 4.4 9.6 6.0 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Allexi_40kDa PF05549.6 KOO30603.1 - 1.2 8.4 8.8 1.6 7.9 2.8 2.3 2 1 0 2 2 2 0 Allexivirus 40kDa protein ALMT PF11744.3 KOO30603.1 - 4.7 5.7 8.5 1.4 7.5 2.4 1.9 2 0 0 2 2 2 0 Aluminium activated malate transporter DUF2580 PF10824.3 KOO30603.1 - 6 7.2 11.7 1.7 9.0 0.8 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2580) Tup_N PF08581.5 KOO30603.1 - 6.6 7.0 6.6 1.8 8.8 0.6 2.8 2 1 0 3 3 3 0 Tup N-terminal DEAD PF00270.24 KOO30604.1 - 0.055 12.9 0.1 0.43 10.0 0.0 2.5 2 1 0 2 2 2 0 DEAD/DEAH box helicase Abhydrolase_6 PF12697.2 KOO30605.1 - 0.00048 20.0 0.0 0.0016 18.4 0.0 1.8 1 0 0 1 1 1 1 Alpha/beta hydrolase family zf-PARP PF00645.13 KOO30605.1 - 0.0082 16.3 0.0 0.018 15.2 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region Ank PF00023.25 KOO30606.1 - 5e-19 67.0 3.5 3e-07 29.9 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.2 KOO30606.1 - 1.4e-18 66.9 0.1 1.3e-10 41.4 0.0 3.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO30606.1 - 1.4e-16 60.4 0.4 2e-11 44.0 0.0 3.5 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO30606.1 - 5.8e-12 45.4 5.5 8.6e-07 29.0 0.0 4.0 2 1 2 4 4 4 4 Ankyrin repeats (many copies) TPR_11 PF13414.1 KOO30606.1 - 3.5e-09 36.1 19.5 1.3e-07 31.1 7.0 2.4 1 1 1 2 2 2 2 TPR repeat Ank_3 PF13606.1 KOO30606.1 - 4.5e-09 35.6 0.1 0.0024 17.9 0.0 4.3 3 0 0 3 3 3 2 Ankyrin repeat TPR_2 PF07719.12 KOO30606.1 - 5.8e-05 22.7 14.3 0.00076 19.2 0.2 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO30606.1 - 0.017 14.9 2.0 1.3 8.9 0.1 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOO30606.1 - 0.024 14.2 0.1 0.024 14.2 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 KOO30606.1 - 0.041 14.2 6.4 0.11 12.8 4.5 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO30606.1 - 0.13 12.9 12.1 0.35 11.6 1.3 3.5 2 0 0 2 2 2 0 Tetratricopeptide repeat BTAD PF03704.12 KOO30606.1 - 0.28 11.4 10.1 0.5 10.6 5.4 2.8 3 1 0 3 3 3 0 Bacterial transcriptional activator domain TPR_6 PF13174.1 KOO30606.1 - 0.32 11.5 2.9 3.7 8.2 0.1 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.1 KOO30606.1 - 9.4 7.0 29.5 0.28 11.9 11.2 3.9 3 1 1 4 4 3 0 Tetratricopeptide repeat PolyA_pol PF01743.15 KOO30607.1 - 1.8e-11 44.3 0.0 4.6e-09 36.5 0.0 2.7 2 1 0 2 2 2 2 Poly A polymerase head domain 2OG-FeII_Oxy PF03171.15 KOO30609.1 - 0.04 14.2 0.0 0.1 12.9 0.0 1.7 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily LRR_6 PF13516.1 KOO30610.1 - 7.8e-23 77.9 6.0 0.017 15.0 0.0 8.3 8 0 0 8 8 8 6 Leucine Rich repeat LRR_1 PF00560.28 KOO30610.1 - 2.8e-11 41.8 0.9 1.8 8.9 0.1 7.7 8 0 0 8 8 8 2 Leucine Rich Repeat LRR_4 PF12799.2 KOO30610.1 - 1.2e-09 37.5 9.1 0.015 14.9 0.0 5.4 5 1 0 5 5 5 3 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO30610.1 - 3.3e-09 35.4 6.1 2.1 8.8 0.2 7.5 8 0 0 8 8 8 2 Leucine rich repeat LRR_8 PF13855.1 KOO30610.1 - 1.1e-05 25.1 7.8 0.99 9.2 0.2 6.1 6 2 0 6 6 6 2 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO30610.1 - 0.014 15.5 0.2 9.7 6.4 0.0 3.0 3 0 0 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding EIF_2_alpha PF07541.7 KOO30610.1 - 0.056 13.1 0.2 2.3 7.9 0.0 2.9 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 2 alpha subunit SQS_PSY PF00494.14 KOO30611.1 - 2.2e-73 246.8 0.3 2.8e-73 246.4 0.2 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase Beach PF02138.13 KOO30612.1 - 7.2e-106 353.5 0.0 9.9e-106 353.1 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.1 KOO30612.1 - 8.9e-22 76.9 0.0 1.5e-21 76.2 0.0 1.3 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.27 KOO30612.1 - 3e-18 64.9 3.3 2.2e-06 27.2 0.0 4.9 4 0 0 4 4 4 3 WD domain, G-beta repeat Laminin_G_3 PF13385.1 KOO30612.1 - 3.9e-08 33.6 0.0 1e-07 32.2 0.0 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF1088 PF06469.6 KOO30612.1 - 0.00055 19.3 4.9 0.0011 18.4 3.4 1.3 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1088) tRNA-synt_1d PF00750.14 KOO30613.1 - 1.3e-93 313.6 0.0 3.7e-93 312.1 0.0 1.6 1 1 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.10 KOO30613.1 - 1.2e-25 89.7 0.0 3.5e-25 88.2 0.0 1.8 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.11 KOO30613.1 - 1.1e-10 41.9 0.1 2.6e-10 40.7 0.0 1.7 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1e PF01406.14 KOO30613.1 - 0.015 14.4 0.0 0.025 13.7 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain tRNA-synt_1 PF00133.17 KOO30613.1 - 0.021 12.8 0.0 0.032 12.2 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 KOO30613.1 - 0.078 11.6 0.0 0.13 10.8 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (M) Syd PF07348.7 KOO30613.1 - 0.085 12.1 0.1 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Syd protein (SUKH-2) SapB_2 PF03489.12 KOO30613.1 - 0.4 10.7 1.5 0.88 9.6 0.1 2.3 2 0 0 2 2 2 0 Saposin-like type B, region 2 DUF2828 PF11443.3 KOO30614.1 - 7.1e-66 222.5 0.0 1.8e-47 161.7 0.0 4.0 1 1 2 3 3 3 3 Domain of unknown function (DUF2828) VWA_CoxE PF05762.9 KOO30614.1 - 3e-05 23.2 0.0 7.4e-05 21.9 0.0 1.6 2 0 0 2 2 2 1 VWA domain containing CoxE-like protein RRM_1 PF00076.17 KOO30615.1 - 3.7e-37 125.7 0.7 4.4e-18 64.6 0.0 3.6 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO30615.1 - 4.4e-31 106.6 0.2 3.1e-14 52.6 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO30615.1 - 5.2e-22 77.4 0.2 5.9e-07 29.2 0.0 3.9 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.1 KOO30615.1 - 1.4e-09 38.0 0.0 3.2e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein Limkain-b1 PF11608.3 KOO30615.1 - 0.0077 15.9 0.1 0.13 11.9 0.0 2.9 4 0 0 4 4 4 1 Limkain b1 RRM_3 PF08777.6 KOO30615.1 - 0.089 12.6 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 RNA binding motif UBX PF00789.15 KOO30616.1 - 8.7e-05 22.5 0.0 0.0011 18.9 0.0 2.2 1 1 0 1 1 1 1 UBX domain Pyrophosphatase PF00719.14 KOO30619.1 - 7.5e-41 139.1 0.0 9.4e-41 138.8 0.0 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase Phos_pyr_kin PF08543.7 KOO30620.1 - 3.4e-10 39.5 0.0 4.5e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.19 KOO30620.1 - 2.2e-08 33.5 0.0 2.9e-06 26.6 0.0 2.1 2 0 0 2 2 2 2 pfkB family carbohydrate kinase NACHT PF05729.7 KOO30621.1 - 0.00012 21.7 0.1 0.00026 20.6 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.1 KOO30621.1 - 0.31 11.0 7.6 0.27 11.2 0.2 4.0 3 1 1 4 4 4 0 AAA ATPase domain PHD PF00628.24 KOO30622.1 - 9.1e-10 38.0 5.1 1.5e-09 37.3 3.5 1.4 1 0 0 1 1 1 1 PHD-finger zf-RING-like PF08746.6 KOO30622.1 - 0.0011 18.8 0.8 0.0027 17.6 0.5 1.7 1 0 0 1 1 1 1 RING-like domain FANCL_C PF11793.3 KOO30622.1 - 0.0097 15.8 5.4 0.055 13.4 3.7 2.2 1 1 0 1 1 1 1 FANCL C-terminal domain zf-HC5HC2H PF13771.1 KOO30622.1 - 0.12 12.5 1.3 0.21 11.7 0.9 1.4 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-RING_2 PF13639.1 KOO30622.1 - 0.13 12.1 4.9 0.25 11.2 3.4 1.5 1 0 0 1 1 1 0 Ring finger domain RINGv PF12906.2 KOO30622.1 - 1.4 8.9 4.3 2.5 8.2 3.0 1.4 1 0 0 1 1 1 0 RING-variant domain DZR PF12773.2 KOO30622.1 - 1.5 8.7 5.4 13 5.7 3.7 2.3 1 1 0 1 1 1 0 Double zinc ribbon CT47 PF15623.1 KOO30623.1 - 1.1 8.9 14.5 1.5 8.4 10.0 1.3 1 0 0 1 1 1 0 Cancer/testis gene family 47 Amidohydro_5 PF13594.1 KOO30624.1 - 7.7e-05 22.4 0.0 0.00021 21.0 0.0 1.8 1 0 0 1 1 1 1 Amidohydrolase ABC_membrane PF00664.18 KOO30624.1 - 0.00028 20.3 0.1 0.00048 19.6 0.1 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region Amidohydro_4 PF13147.1 KOO30624.1 - 0.00044 20.3 0.0 0.00088 19.3 0.0 1.5 1 0 0 1 1 1 1 Amidohydrolase Pkinase PF00069.20 KOO30625.1 - 7.7e-28 97.3 0.0 8.7e-28 97.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO30625.1 - 1.5e-12 47.1 0.0 1.7e-12 46.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO30625.1 - 1.8e-05 23.8 0.1 2.5e-05 23.3 0.0 1.3 1 1 0 1 1 1 1 Kinase-like CENP-Q PF13094.1 KOO30626.1 - 0.00091 19.2 9.7 0.0011 18.9 6.7 1.1 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit ALIX_LYPXL_bnd PF13949.1 KOO30626.1 - 0.0031 16.5 7.6 0.0037 16.2 5.3 1.1 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV DUF1640 PF07798.6 KOO30626.1 - 0.006 16.6 1.4 0.0066 16.4 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) LRS4 PF10422.4 KOO30626.1 - 0.095 12.0 2.9 0.11 11.8 2.0 1.2 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 Serpin PF00079.15 KOO30626.1 - 0.24 10.5 1.7 0.26 10.3 1.2 1.0 1 0 0 1 1 1 0 Serpin (serine protease inhibitor) Mt_ATP-synt_B PF05405.9 KOO30626.1 - 0.27 10.6 4.8 0.33 10.3 3.4 1.2 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) IncA PF04156.9 KOO30626.1 - 0.31 10.5 7.4 0.4 10.2 5.1 1.2 1 0 0 1 1 1 0 IncA protein Borrelia_P83 PF05262.6 KOO30626.1 - 0.34 9.1 6.3 0.37 8.9 4.4 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Herpes_UL6 PF01763.11 KOO30626.1 - 0.35 8.9 3.2 0.37 8.9 2.2 1.0 1 0 0 1 1 1 0 Herpesvirus UL6 like Atg14 PF10186.4 KOO30626.1 - 0.43 9.4 8.2 0.46 9.3 5.7 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Striatin PF08232.7 KOO30626.1 - 0.43 10.8 6.9 0.57 10.4 4.8 1.2 1 0 0 1 1 1 0 Striatin family ERM PF00769.14 KOO30626.1 - 0.52 9.8 12.7 0.59 9.6 8.8 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family SecA_DEAD PF07517.9 KOO30626.1 - 0.58 9.3 3.4 0.67 9.1 2.3 1.1 1 0 0 1 1 1 0 SecA DEAD-like domain HAUS-augmin3 PF14932.1 KOO30626.1 - 0.63 9.1 8.4 0.68 9.0 5.8 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 OmpH PF03938.9 KOO30626.1 - 0.8 9.6 13.2 0.96 9.3 9.2 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) FYVE_2 PF02318.11 KOO30626.1 - 0.87 9.5 4.0 0.66 9.8 1.7 1.6 1 1 1 2 2 2 0 FYVE-type zinc finger DUF4200 PF13863.1 KOO30626.1 - 0.96 9.4 12.1 1.4 8.9 8.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) FUSC PF04632.7 KOO30626.1 - 1.3 7.3 13.3 1.6 7.0 9.2 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4407 PF14362.1 KOO30626.1 - 1.5 7.7 9.7 1.7 7.4 6.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) VIT1 PF01988.14 KOO30626.1 - 1.5 8.2 5.2 1.9 7.9 3.6 1.1 1 0 0 1 1 1 0 VIT family Mnd1 PF03962.10 KOO30626.1 - 1.6 8.3 6.8 2 8.0 4.7 1.1 1 0 0 1 1 1 0 Mnd1 family ADIP PF11559.3 KOO30626.1 - 1.9 8.3 11.8 2.3 8.0 8.2 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding HisKA_3 PF07730.8 KOO30626.1 - 2.5 8.5 11.7 3.6 8.0 0.2 2.3 2 0 0 2 2 2 0 Histidine kinase HlyD PF00529.15 KOO30626.1 - 3 7.0 17.2 3.4 6.8 12.0 1.0 1 0 0 1 1 1 0 HlyD family secretion protein DUF3708 PF12501.3 KOO30626.1 - 5.1 6.9 9.1 5.4 6.8 5.7 1.4 1 1 0 1 1 1 0 Phosphate ATP-binding cassette transporter DivIVA PF05103.8 KOO30626.1 - 9.4 6.2 11.6 12 5.8 8.0 1.2 1 0 0 1 1 1 0 DivIVA protein MMtag PF10159.4 KOO30627.1 - 5.2e-30 103.3 5.3 1.3e-29 102.0 3.6 1.7 1 0 0 1 1 1 1 Kinase phosphorylation protein DUF3367 PF11847.3 KOO30628.1 - 0.048 11.6 4.7 0.056 11.3 3.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3367) Drc1-Sld2 PF11719.3 KOO30628.1 - 0.14 11.2 0.6 0.15 11.0 0.4 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein MMPL PF03176.10 KOO30629.1 - 5.2e-49 166.7 27.1 1.7e-28 99.3 4.6 2.9 2 1 0 2 2 2 2 MMPL family LSM PF01423.17 KOO30631.1 - 8.5e-19 66.8 0.5 1.2e-18 66.4 0.4 1.1 1 0 0 1 1 1 1 LSM domain Prefoldin_2 PF01920.15 KOO30631.1 - 0.055 13.2 0.3 0.088 12.5 0.2 1.4 1 0 0 1 1 1 0 Prefoldin subunit EIF_2_alpha PF07541.7 KOO30631.1 - 0.082 12.6 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit Peptidase_C2 PF00648.16 KOO30633.1 - 2.5e-61 207.2 0.2 1.5e-59 201.4 0.0 2.2 2 0 0 2 2 2 2 Calpain family cysteine protease UIM PF02809.15 KOO30633.1 - 1.2e-06 27.5 16.2 0.011 15.2 1.9 4.3 3 0 0 3 3 3 2 Ubiquitin interaction motif zf-Sec23_Sec24 PF04810.10 KOO30633.1 - 0.00063 19.2 0.7 0.034 13.6 0.2 2.7 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger LRR_8 PF13855.1 KOO30633.1 - 0.012 15.4 4.0 2 8.2 0.8 2.9 1 1 0 2 2 2 0 Leucine rich repeat Type_III_YscX PF09474.5 KOO30633.1 - 0.2 11.6 4.5 7.4 6.6 0.4 2.4 1 1 1 2 2 2 0 Type III secretion system YscX (type_III_YscX) LRR_4 PF12799.2 KOO30633.1 - 0.57 9.8 11.6 2.9e+02 1.2 8.0 3.1 1 1 0 1 1 1 0 Leucine Rich repeats (2 copies) Proteasome PF00227.21 KOO30634.1 - 1.9e-48 164.2 0.3 2.6e-48 163.8 0.2 1.2 1 0 0 1 1 1 1 Proteasome subunit p25-alpha PF05517.7 KOO30635.1 - 4.7e-07 30.1 0.0 4e-05 23.9 0.0 2.7 3 0 0 3 3 3 1 p25-alpha MiaE_2 PF13794.1 KOO30635.1 - 0.031 13.7 2.8 0.65 9.4 0.1 2.6 3 0 0 3 3 3 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like GCR PF02155.10 KOO30636.1 - 0.0048 15.6 0.1 0.0081 14.9 0.1 1.2 1 0 0 1 1 1 1 Glucocorticoid receptor DUF1863 PF08937.6 KOO30636.1 - 0.012 15.6 0.0 0.1 12.6 0.0 2.5 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) HR1 PF02185.11 KOO30636.1 - 0.082 12.6 3.5 0.19 11.4 2.5 1.6 1 0 0 1 1 1 0 Hr1 repeat Clp1 PF06807.9 KOO30637.1 - 2.3e-05 24.2 0.0 3.6e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 Aldedh PF00171.17 KOO30640.1 - 1.8e-11 43.0 0.0 1e-10 40.5 0.0 2.1 2 1 0 2 2 2 1 Aldehyde dehydrogenase family DcuC PF03606.10 KOO30640.1 - 0.015 13.5 0.1 0.022 13.0 0.1 1.1 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier Acetyltransf_1 PF00583.19 KOO30641.1 - 0.022 14.7 0.1 0.045 13.7 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) family DOG1 PF14144.1 KOO30642.1 - 1.1 9.2 6.0 1.1 9.3 0.6 2.8 2 0 0 2 2 2 0 Seed dormancy control TATR PF03430.8 KOO30642.1 - 1.5 7.3 8.2 2 6.9 5.7 1.2 1 0 0 1 1 1 0 Trans-activating transcriptional regulator Kinesin PF00225.18 KOO30643.1 - 0.0023 16.6 0.0 0.0029 16.3 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain UCH PF00443.24 KOO30644.1 - 6.7e-16 58.1 0.0 9e-16 57.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-C2H2 PF00096.21 KOO30644.1 - 0.2 12.0 3.3 3.6 8.1 0.3 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2HC_2 PF13913.1 KOO30644.1 - 2.4 7.9 5.8 1.2 8.8 1.8 2.1 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Baculo_PEP_C PF04513.7 KOO30646.1 - 1.1 9.0 4.4 1.9 8.2 0.7 2.8 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4203 PF13886.1 KOO30647.1 - 0.0096 15.3 3.4 0.012 15.1 2.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) DUF4245 PF14030.1 KOO30647.1 - 0.031 14.0 0.1 0.039 13.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4245) Tmp39 PF10271.4 KOO30647.1 - 0.12 10.9 0.1 0.16 10.5 0.1 1.1 1 0 0 1 1 1 0 Putative transmembrane protein 4F5 PF04419.9 KOO30647.1 - 0.34 11.6 3.0 0.57 10.9 2.1 1.4 1 0 0 1 1 1 0 4F5 protein family Myb_DNA-binding PF00249.26 KOO30648.1 - 0.00049 20.0 0.0 0.00097 19.1 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO30648.1 - 0.0013 18.8 0.0 0.0026 17.8 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Chromo PF00385.19 KOO30648.1 - 0.0083 15.7 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Glyco_hydro_16 PF00722.16 KOO30649.1 - 4.8e-10 39.0 0.1 0.00088 18.6 0.0 2.4 2 0 0 2 2 2 2 Glycosyl hydrolases family 16 SKN1 PF03935.10 KOO30649.1 - 0.0038 15.4 6.6 0.022 12.9 0.0 2.8 3 0 0 3 3 3 2 Beta-glucan synthesis-associated protein (SKN1) SNF2_N PF00176.18 KOO30650.1 - 1.8e-11 43.3 0.0 2.8e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 KOO30650.1 - 5.5e-06 25.9 0.0 1e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 KOO30650.1 - 2e-05 24.5 0.0 4.8e-05 23.2 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Imm46 PF15585.1 KOO30652.1 - 0.11 12.5 2.9 0.14 12.2 0.2 2.5 2 0 0 2 2 2 0 Immunity protein 46 Reo_sigmaC PF04582.7 KOO30652.1 - 6.9 5.7 10.1 12 4.9 0.3 3.3 1 1 1 4 4 4 0 Reovirus sigma C capsid protein Sulfate_transp PF00916.15 KOO30654.1 - 1e-07 31.2 3.0 1e-07 31.2 2.1 2.3 3 0 0 3 3 3 1 Sulfate transporter family Nup35_RRM PF05172.8 KOO30654.1 - 5.2e-07 29.3 0.0 2.7e-06 27.0 0.0 2.0 1 1 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.1 KOO30654.1 - 3.1e-05 23.6 0.0 6.4e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif GPI-anchored PF10342.4 KOO30655.1 - 3.5e-10 40.2 0.0 8.6e-10 38.9 0.0 1.7 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family EGF_2 PF07974.8 KOO30655.1 - 0.00024 21.1 7.3 0.00024 21.1 5.1 7.9 7 1 1 8 8 8 4 EGF-like domain Pkinase PF00069.20 KOO30656.1 - 4e-41 140.8 0.0 1e-40 139.5 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO30656.1 - 1e-25 90.3 0.0 2.2e-25 89.2 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase IPK PF03770.11 KOO30656.1 - 2.4e-08 33.8 0.0 4.5e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Inositol polyphosphate kinase Kinase-like PF14531.1 KOO30656.1 - 6.9e-07 28.5 0.0 1.2e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO30656.1 - 0.019 14.7 0.0 0.069 12.8 0.0 2.0 1 0 0 1 1 1 0 Phosphotransferase enzyme family KH_1 PF00013.24 KOO30657.1 - 3.6e-51 170.6 18.4 8.2e-15 54.2 0.9 5.1 5 0 0 5 5 5 4 KH domain KH_3 PF13014.1 KOO30657.1 - 1.8e-37 126.3 19.6 1.1e-10 40.8 1.5 4.4 4 0 0 4 4 4 4 KH domain KH_4 PF13083.1 KOO30657.1 - 9.8e-16 57.1 9.6 0.0028 17.2 0.2 4.7 4 0 0 4 4 4 4 KH domain KH_2 PF07650.12 KOO30657.1 - 6.2e-12 44.9 13.7 0.004 16.6 0.7 4.6 3 1 1 4 4 4 4 KH domain KH_5 PF13184.1 KOO30657.1 - 6.3e-06 25.9 11.2 1.9 8.3 0.2 5.1 5 0 0 5 5 5 4 NusA-like KH domain SLS PF14611.1 KOO30657.1 - 0.0016 17.8 0.6 0.15 11.4 0.0 3.3 4 0 0 4 4 4 1 Mitochondrial inner-membrane-bound regulator BMC PF00936.14 KOO30657.1 - 0.077 12.6 4.5 2 8.1 0.1 3.8 5 0 0 5 5 5 0 BMC domain Arg_repressor PF01316.16 KOO30657.1 - 0.12 11.9 0.0 0.27 10.8 0.0 1.5 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain MscS_porin PF12795.2 KOO30658.1 - 0.00035 19.9 13.5 0.00043 19.6 9.3 1.0 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain SCAN PF02023.12 KOO30658.1 - 0.0022 17.4 3.8 0.011 15.1 2.4 2.0 2 0 0 2 2 2 1 SCAN domain YgaB PF14182.1 KOO30658.1 - 2.1 8.6 9.3 12 6.1 0.0 2.3 2 1 0 2 2 2 0 YgaB-like protein IncA PF04156.9 KOO30658.1 - 3.9 7.0 12.7 6.1 6.4 8.8 1.3 1 1 0 1 1 1 0 IncA protein Pkinase PF00069.20 KOO30659.1 - 1.3e-46 158.8 0.0 1.8e-46 158.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO30659.1 - 1.8e-39 135.3 0.0 3e-39 134.6 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO30659.1 - 0.00022 20.2 0.0 0.00035 19.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO30659.1 - 0.041 13.6 0.2 0.21 11.2 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family V-SNARE PF05008.10 KOO30660.1 - 6.9e-14 51.7 4.3 1.8e-13 50.4 3.0 1.7 1 0 0 1 1 1 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.3 KOO30660.1 - 4.8e-13 48.9 4.5 1.4e-12 47.5 3.1 1.9 1 1 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus DegT_DnrJ_EryC1 PF01041.12 KOO30660.1 - 0.039 12.9 0.5 0.17 10.8 0.1 1.8 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family E2R135 PF11570.3 KOO30660.1 - 0.31 11.1 2.3 0.82 9.7 0.1 2.2 2 1 0 2 2 2 0 Coiled-coil receptor-binding R-domain of colicin E2 PAS PF00989.19 KOO30661.1 - 1e-159 521.4 5.9 9.6e-25 86.5 0.0 8.5 8 0 0 8 8 8 7 PAS fold PAS_9 PF13426.1 KOO30661.1 - 2.1e-106 349.3 15.3 2.6e-17 63.1 0.0 8.5 8 0 0 8 8 8 7 PAS domain PAS_4 PF08448.5 KOO30661.1 - 1.9e-85 282.1 1.5 3.3e-13 49.6 0.0 8.7 8 0 0 8 8 8 8 PAS fold PAS_3 PF08447.6 KOO30661.1 - 1.2e-42 143.8 0.0 2.1e-08 34.1 0.0 7.5 7 0 0 7 7 7 7 PAS fold PAS_8 PF13188.1 KOO30661.1 - 2.8e-31 106.2 6.0 0.00044 20.0 0.0 7.7 7 0 0 7 7 7 7 PAS domain HATPase_c PF02518.21 KOO30661.1 - 1.3e-24 86.0 0.0 5.7e-24 83.9 0.0 2.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 KOO30661.1 - 2.9e-23 82.0 0.0 7.3e-23 80.7 0.0 1.8 1 0 0 1 1 1 1 Response regulator receiver domain PAS_10 PF13596.1 KOO30661.1 - 8.4e-22 77.4 1.2 1.1e-05 25.6 0.0 7.5 7 0 0 7 7 7 5 PAS domain HisKA PF00512.20 KOO30661.1 - 3.3e-17 62.2 2.8 7.8e-17 61.0 0.0 3.4 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain Hpt PF01627.18 KOO30661.1 - 4.1e-15 55.5 24.6 1.6e-07 31.2 0.3 5.4 5 0 0 5 5 5 3 Hpt domain PAS_7 PF12860.2 KOO30661.1 - 5.6e-09 36.0 6.0 1.6 8.7 0.0 8.5 8 2 0 8 8 8 2 PAS fold DUF2634 PF10934.3 KOO30661.1 - 0.0016 18.1 0.8 45 3.8 0.0 4.8 5 0 0 5 5 4 0 Protein of unknown function (DUF2634) ORF6C PF10552.4 KOO30661.1 - 0.013 15.1 1.0 16 5.2 0.0 3.9 4 0 0 4 4 4 0 ORF6C domain TBP PF00352.16 KOO30662.1 - 1.2e-70 232.8 0.1 8.3e-35 118.0 0.0 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.3 KOO30662.1 - 2.7e-06 27.3 0.0 0.081 12.9 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) His_Phos_2 PF00328.17 KOO30664.1 - 9e-10 38.3 0.0 2.3e-08 33.7 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Choline_transpo PF04515.7 KOO30665.1 - 3.2e-46 157.5 39.7 3.2e-46 157.5 27.5 1.9 2 0 0 2 2 2 1 Plasma-membrane choline transporter hEGF PF12661.2 KOO30665.1 - 8e-05 22.4 47.8 0.58 10.3 2.1 8.1 7 0 0 7 7 7 6 Human growth factor-like EGF EGF_2 PF07974.8 KOO30665.1 - 0.0011 19.1 115.8 0.046 13.8 8.6 7.6 7 0 0 7 7 7 5 EGF-like domain Rifin_STEVOR PF02009.11 KOO30665.1 - 0.12 11.9 1.4 4.8 6.7 0.1 2.2 2 0 0 2 2 2 0 Rifin/stevor family ShK PF01549.19 KOO30666.1 - 7.9e-52 173.3 71.0 7.2e-11 42.2 4.5 6.1 6 0 0 6 6 6 6 ShK domain-like zf-CCCH PF00642.19 KOO30666.1 - 0.0064 16.1 5.1 4.1 7.2 0.1 5.3 5 0 0 5 5 5 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) IQ PF00612.22 KOO30667.1 - 0.00023 20.5 4.7 0.029 13.9 0.1 2.6 2 0 0 2 2 2 2 IQ calmodulin-binding motif CENP-F_leu_zip PF10473.4 KOO30668.1 - 0.0006 19.6 9.3 0.0023 17.7 5.8 1.9 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TSKS PF15358.1 KOO30668.1 - 0.00083 17.6 1.6 0.00094 17.4 1.1 1.0 1 0 0 1 1 1 1 Testis-specific serine kinase substrate DUF1092 PF06485.6 KOO30668.1 - 0.0012 17.8 1.4 0.0013 17.7 1.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1092) WEMBL PF05701.6 KOO30668.1 - 0.0031 16.0 10.7 0.0038 15.7 7.4 1.0 1 0 0 1 1 1 1 Weak chloroplast movement under blue light OmpH PF03938.9 KOO30668.1 - 0.094 12.6 4.1 0.12 12.3 2.8 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TPR_MLP1_2 PF07926.7 KOO30668.1 - 0.1 12.3 8.0 0.044 13.5 3.9 1.5 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein GAS PF13851.1 KOO30668.1 - 0.19 10.9 8.8 0.051 12.7 2.4 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Thioesterase PF00975.15 KOO30668.1 - 0.27 11.4 1.6 0.34 11.0 1.0 1.2 1 1 0 1 1 1 0 Thioesterase domain DUF1515 PF07439.6 KOO30668.1 - 0.28 11.0 2.7 0.38 10.5 1.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) IncA PF04156.9 KOO30668.1 - 1.5 8.3 10.4 3.2 7.3 7.2 1.6 1 1 0 1 1 1 0 IncA protein COG2 PF06148.6 KOO30668.1 - 9.3 6.1 8.5 30 4.4 3.0 2.1 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Glyco_hydro_38 PF01074.17 KOO30669.1 - 1.9e-75 253.6 1.3 2.6e-75 253.2 0.9 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.8 KOO30669.1 - 1.8e-57 195.1 0.0 2.2e-57 194.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Flagellin_IN PF07196.8 KOO30669.1 - 0.11 12.5 0.1 0.32 11.0 0.1 1.8 1 0 0 1 1 1 0 Flagellin hook IN motif EF-hand_7 PF13499.1 KOO30670.1 - 1.1e-16 60.7 0.1 6.2e-07 29.4 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO30670.1 - 3.3e-16 57.6 0.8 0.00045 19.8 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.27 KOO30670.1 - 1.7e-14 51.9 0.0 6.7e-05 21.9 0.0 4.4 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.1 KOO30670.1 - 2.4e-12 45.5 0.1 0.00064 18.9 0.0 4.4 4 0 0 4 4 4 2 EF hand GPS PF01825.16 KOO30670.1 - 7.6e-11 41.9 3.1 7.6e-11 41.9 2.2 2.1 2 0 0 2 2 2 1 Latrophilin/CL-1-like GPS domain EF-hand_8 PF13833.1 KOO30670.1 - 0.017 14.7 0.0 8.3 6.1 0.0 3.4 2 2 2 4 4 4 0 EF-hand domain pair SAP PF02037.22 KOO30670.1 - 0.57 9.7 3.7 35 4.0 0.0 3.3 3 0 0 3 3 3 0 SAP domain Antimicrobial13 PF08108.6 KOO30670.1 - 7.7 6.5 9.4 23 5.0 1.0 2.9 2 0 0 2 2 2 0 Halocidin family Beach PF02138.13 KOO30671.1 - 1.8e-83 280.1 0.0 2.7e-83 279.5 0.0 1.3 1 0 0 1 1 1 1 Beige/BEACH domain VPS9 PF02204.13 KOO30671.1 - 8e-13 48.3 0.0 1.5e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain PH_BEACH PF14844.1 KOO30671.1 - 2.3e-05 24.1 0.2 6.3e-05 22.7 0.0 1.8 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH IQ PF00612.22 KOO30671.1 - 0.016 14.7 0.0 0.039 13.6 0.0 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif COPIIcoated_ERV PF07970.7 KOO30672.1 - 4.6e-24 85.2 0.0 7.5e-24 84.5 0.0 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 KOO30672.1 - 1.6e-12 47.2 0.0 2.8e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Thioredoxin PF00085.15 KOO30672.1 - 3.2e-12 46.0 0.0 7.4e-12 44.8 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin ShK PF01549.19 KOO30672.1 - 3.6e-07 30.4 10.2 0.0027 18.0 1.4 2.5 2 0 0 2 2 2 2 ShK domain-like Thioredoxin_7 PF13899.1 KOO30672.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like TrmB PF01978.14 KOO30674.1 - 0.084 12.5 0.0 15 5.3 0.0 2.6 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB GSH-S_N PF02951.9 KOO30674.1 - 0.28 10.9 5.8 10 5.9 0.0 3.3 3 0 0 3 3 3 0 Prokaryotic glutathione synthetase, N-terminal domain DUF3484 PF11983.3 KOO30675.1 - 0.058 14.2 0.1 0.094 13.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3484) AP2 PF00847.15 KOO30676.1 - 1.8e-06 27.9 5.7 7.1e-05 22.8 0.3 6.5 7 2 1 8 8 8 2 AP2 domain IF3_N PF05198.11 KOO30676.1 - 0.00013 21.8 1.8 1.9 8.4 0.0 3.5 3 0 0 3 3 3 3 Translation initiation factor IF-3, N-terminal domain DUF2493 PF10686.4 KOO30676.1 - 5.3 6.6 13.9 1.4 8.4 0.5 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2493) SecA_SW PF07516.8 KOO30678.1 - 0.0046 16.7 0.1 0.0067 16.2 0.1 1.2 1 0 0 1 1 1 1 SecA Wing and Scaffold domain Pyr_redox_dim PF02852.17 KOO30679.1 - 5.5e-24 84.3 0.1 1.3e-23 83.1 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.9 KOO30679.1 - 3e-21 76.2 4.5 1.4e-19 70.8 3.1 3.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOO30679.1 - 1.7e-16 60.3 0.3 7.6e-16 58.2 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOO30679.1 - 0.00036 20.6 0.0 0.12 12.4 0.0 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 KOO30679.1 - 0.002 17.8 0.6 0.0035 17.0 0.1 1.6 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain adh_short PF00106.20 KOO30679.1 - 0.005 16.7 0.4 0.013 15.4 0.3 1.7 1 0 0 1 1 1 1 short chain dehydrogenase 2-Hacid_dh_C PF02826.14 KOO30679.1 - 0.0099 15.0 0.0 0.021 13.9 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain HI0933_like PF03486.9 KOO30679.1 - 0.022 13.2 0.2 0.91 7.9 0.0 2.9 3 1 0 3 3 3 0 HI0933-like protein FAD_binding_3 PF01494.14 KOO30679.1 - 0.03 13.3 0.2 0.081 11.9 0.1 1.7 1 1 0 1 1 1 0 FAD binding domain XdhC_C PF13478.1 KOO30679.1 - 0.056 13.7 0.1 0.12 12.7 0.1 1.5 1 0 0 1 1 1 0 XdhC Rossmann domain NAD_binding_7 PF13241.1 KOO30679.1 - 0.063 13.5 0.1 0.22 11.8 0.0 1.9 2 0 0 2 2 2 0 Putative NAD(P)-binding Thi4 PF01946.12 KOO30679.1 - 0.064 12.3 0.0 0.2 10.6 0.0 1.8 2 0 0 2 2 2 0 Thi4 family DAO PF01266.19 KOO30679.1 - 1.3 7.8 8.6 1.2 7.9 0.2 2.9 3 0 0 3 3 3 0 FAD dependent oxidoreductase RNA_pol_Rpb2_6 PF00562.23 KOO30681.1 - 7.2e-120 400.2 0.0 1.6e-119 399.0 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_2 PF04561.9 KOO30681.1 - 1.2e-22 80.2 0.0 2.1e-22 79.4 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.11 KOO30681.1 - 1.2e-21 76.2 0.0 2.9e-21 74.9 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.8 KOO30681.1 - 2e-20 72.3 0.2 2e-20 72.3 0.1 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_1 PF04563.10 KOO30681.1 - 7.1e-15 54.4 0.0 1e-14 53.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.15 KOO30681.1 - 2.1e-14 53.5 0.2 5.4e-14 52.2 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_5 PF04567.12 KOO30681.1 - 4.4e-14 52.1 0.1 9.3e-14 51.1 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 CS PF04969.11 KOO30682.1 - 0.036 14.6 0.0 0.056 14.0 0.0 1.4 1 0 0 1 1 1 0 CS domain CDC37_N PF03234.9 KOO30682.1 - 0.088 13.1 11.1 0.24 11.6 0.7 2.3 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding Serglycin PF04360.7 KOO30682.1 - 0.099 12.3 0.2 0.37 10.5 0.0 1.8 2 0 0 2 2 2 0 Serglycin MSP1_C PF07462.6 KOO30682.1 - 1.5 7.1 3.2 2.2 6.5 2.2 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus PP2C PF00481.16 KOO30683.1 - 6.6e-44 150.2 0.0 8.7e-44 149.8 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 KOO30683.1 - 0.0064 15.9 2.8 0.97 8.7 1.9 2.9 1 1 0 1 1 1 1 Protein phosphatase 2C Ion_trans_2 PF07885.11 KOO30684.1 - 4e-33 112.9 43.1 1.3e-10 40.8 0.1 5.4 6 0 0 6 6 6 4 Ion channel IDO PF01231.13 KOO30685.1 - 7e-54 182.8 0.0 3.6e-48 164.0 0.0 4.7 3 1 0 3 3 3 2 Indoleamine 2,3-dioxygenase Cyt-b5 PF00173.23 KOO30685.1 - 1.6e-19 69.4 0.1 7.7e-19 67.2 0.1 2.2 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain DUF630 PF04783.7 KOO30685.1 - 0.012 15.4 0.6 0.14 12.0 0.0 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF630) Ion_trans_2 PF07885.11 KOO30686.1 - 1e-07 31.5 0.1 1.7e-07 30.8 0.1 1.3 1 0 0 1 1 1 1 Ion channel Tub PF01167.13 KOO30689.1 - 1.5e-87 292.6 0.0 2.4e-87 291.9 0.0 1.3 1 0 0 1 1 1 1 Tub family Ion_trans PF00520.26 KOO30690.1 - 2.4e-28 98.7 14.4 2.9e-28 98.4 10.0 1.1 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.7 KOO30690.1 - 0.0077 14.7 15.9 0.055 11.8 5.5 3.0 2 1 0 2 2 2 2 Polycystin cation channel Suppressor_APC PF11414.3 KOO30690.1 - 0.061 13.1 0.6 0.11 12.2 0.4 1.5 1 0 0 1 1 1 0 Adenomatous polyposis coli tumour suppressor protein Prefoldin PF02996.12 KOO30691.1 - 5.7e-18 64.6 0.2 7.3e-18 64.3 0.1 1.1 1 0 0 1 1 1 1 Prefoldin subunit Laminin_I PF06008.9 KOO30691.1 - 0.083 12.2 4.3 0.34 10.1 0.2 2.0 2 0 0 2 2 2 0 Laminin Domain I Methyltransf_11 PF08241.7 KOO30692.1 - 2.1e-17 63.3 0.0 3.8e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO30692.1 - 4.9e-13 48.7 0.0 1.3e-11 44.0 0.0 2.1 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 KOO30692.1 - 3.9e-12 46.0 0.0 6.1e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO30692.1 - 1.3e-11 44.7 0.0 2.3e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO30692.1 - 1.6e-11 44.5 0.0 2.5e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO30692.1 - 7.3e-11 42.6 0.0 1.3e-10 41.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO30692.1 - 2.9e-10 40.0 0.0 4.6e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO30692.1 - 2.4e-06 27.5 0.4 1.2e-05 25.3 0.1 2.2 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 KOO30692.1 - 0.0067 15.8 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.1 KOO30692.1 - 0.022 14.4 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.15 KOO30692.1 - 0.13 11.2 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase G6B PF15096.1 KOO30693.1 - 0.00025 20.6 5.1 0.038 13.5 0.1 2.2 1 1 1 2 2 2 2 G6B family LELP1 PF15042.1 KOO30693.1 - 0.011 15.8 0.2 0.011 15.8 0.1 2.3 1 1 1 2 2 2 0 Late cornified envelope-like proline-rich protein 1 SNF2_N PF00176.18 KOO30694.1 - 3.2e-75 252.7 0.0 4.4e-75 252.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain RCC1 PF00415.13 KOO30694.1 - 9.6e-40 134.5 28.3 1.5e-08 34.7 0.0 8.4 7 2 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO30694.1 - 2.3e-31 106.7 35.6 7.4e-07 28.6 0.1 7.8 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Helicase_C PF00271.26 KOO30694.1 - 8.7e-16 57.5 0.0 5.7e-14 51.7 0.0 2.8 3 0 0 3 3 2 1 Helicase conserved C-terminal domain TPR_11 PF13414.1 KOO30694.1 - 6.6e-15 54.5 6.2 4.8e-09 35.7 0.4 3.5 1 1 2 3 3 3 3 TPR repeat PHD PF00628.24 KOO30694.1 - 2e-10 40.1 8.0 2e-10 40.1 5.5 3.5 3 0 0 3 3 3 2 PHD-finger DEAD PF00270.24 KOO30694.1 - 2e-09 37.1 0.0 3.9e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 KOO30694.1 - 2.1e-06 27.6 0.0 7.6e-06 25.8 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.3 KOO30694.1 - 2.9e-06 26.2 0.0 8.5e-06 24.7 0.0 1.6 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 TPR_2 PF07719.12 KOO30694.1 - 0.00024 20.7 12.7 0.1 12.5 0.5 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat zf-PHD-like PF15446.1 KOO30694.1 - 0.0055 16.0 0.5 0.0055 16.0 0.4 1.8 2 0 0 2 2 1 1 PHD/FYVE-zinc-finger like domain AAA_22 PF13401.1 KOO30694.1 - 0.0099 16.0 1.7 0.025 14.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain TPR_17 PF13431.1 KOO30694.1 - 0.015 15.4 0.1 1.1 9.6 0.0 3.6 3 1 0 4 4 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOO30694.1 - 0.039 13.5 12.8 0.069 12.7 0.4 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Peptidase_C26 PF07722.8 KOO30694.1 - 0.13 11.7 0.0 0.28 10.5 0.0 1.5 1 0 0 1 1 1 0 Peptidase C26 TPR_8 PF13181.1 KOO30694.1 - 0.13 12.1 2.4 2.7 7.9 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Cu-oxidase_2 PF07731.9 KOO30695.1 - 4.2e-12 45.7 8.0 1.4e-07 31.0 0.7 4.7 4 1 0 4 4 4 3 Multicopper oxidase Cu-oxidase_3 PF07732.10 KOO30695.1 - 4.5e-11 42.5 2.0 4.7e-07 29.5 0.1 4.8 5 1 0 5 5 5 2 Multicopper oxidase MORN PF02493.15 KOO30696.1 - 4.5e-163 519.9 316.7 7.9e-07 28.4 0.1 58.0 60 0 0 60 60 60 47 MORN repeat DUF448 PF04296.8 KOO30696.1 - 0.46 10.1 1.2 21 4.8 0.0 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF448) Ank_2 PF12796.2 KOO30698.1 - 1.8e-68 226.8 20.5 1.2e-14 54.3 2.1 8.1 3 1 4 7 7 7 6 Ankyrin repeats (3 copies) Ank PF00023.25 KOO30698.1 - 5.9e-62 202.5 28.9 1.1e-05 24.9 0.0 14.1 14 1 0 14 14 14 12 Ankyrin repeat Ank_4 PF13637.1 KOO30698.1 - 7.4e-47 156.9 14.2 2.5e-08 34.2 0.0 10.2 5 2 5 11 11 11 9 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO30698.1 - 5.3e-45 146.9 17.7 0.0019 18.2 0.0 14.8 15 0 0 15 15 15 12 Ankyrin repeat Ank_5 PF13857.1 KOO30698.1 - 1.1e-44 149.4 30.0 4.4e-08 33.1 0.1 11.5 4 2 10 14 14 14 11 Ankyrin repeats (many copies) WD40 PF00400.27 KOO30701.1 - 4.9e-80 260.8 27.8 2.3e-12 46.3 0.1 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat Arm PF00514.18 KOO30701.1 - 3.6e-29 99.5 24.4 3.5e-07 29.8 0.0 8.6 8 0 0 8 8 8 6 Armadillo/beta-catenin-like repeat PD40 PF07676.7 KOO30701.1 - 1.2e-15 56.7 5.0 1.2 8.9 0.0 7.5 7 0 0 7 7 7 6 WD40-like Beta Propeller Repeat HEAT_2 PF13646.1 KOO30701.1 - 6.1e-13 48.8 35.1 2e-05 24.7 1.4 5.4 4 1 1 5 5 5 4 HEAT repeats eIF2A PF08662.6 KOO30701.1 - 9.6e-10 38.4 0.8 0.00021 21.0 0.1 3.1 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.11 KOO30701.1 - 1.7e-07 29.8 0.9 0.0084 14.4 0.0 3.4 1 1 2 3 3 3 3 Cytochrome D1 heme domain Nbas_N PF15492.1 KOO30701.1 - 1e-05 24.8 5.7 1.4 7.9 0.1 5.3 1 1 5 6 6 6 2 Neuroblastoma-amplified sequence, N terminal TFIIIC_delta PF12657.2 KOO30701.1 - 2e-05 24.3 5.1 0.014 15.0 0.1 3.6 2 1 1 3 3 3 3 Transcription factor IIIC subunit delta N-term HEAT PF02985.17 KOO30701.1 - 3.6e-05 23.4 22.6 0.074 13.1 0.1 7.7 8 0 0 8 8 8 2 HEAT repeat DUF3312 PF11768.3 KOO30701.1 - 9e-05 20.8 0.0 2.7 6.1 0.0 4.1 1 1 4 5 5 5 1 Protein of unknown function (DUF3312) Nup160 PF11715.3 KOO30701.1 - 0.00046 18.4 5.0 0.32 9.0 0.1 3.8 1 1 1 3 3 3 2 Nucleoporin Nup120/160 DUF3892 PF13031.1 KOO30701.1 - 0.0025 18.1 4.2 4.2 7.8 0.0 4.5 3 1 1 5 5 4 2 Protein of unknown function (DUF3892) LigD_N PF13298.1 KOO30701.1 - 0.0029 17.6 0.4 13 5.9 0.0 4.3 2 2 2 4 4 4 0 DNA polymerase Ligase (LigD) IKI3 PF04762.7 KOO30701.1 - 0.0036 15.2 2.7 0.057 11.2 0.5 2.8 1 1 0 2 2 2 1 IKI3 family DUF4467 PF14729.1 KOO30701.1 - 0.059 13.7 0.0 1.8e+02 2.5 0.0 4.1 2 1 1 4 4 4 0 Domain of unknown function with cystatin-like fold (DUF4467) Rep_fac-A_C PF08646.5 KOO30701.1 - 0.11 12.1 0.1 15 5.2 0.0 3.7 3 1 2 5 5 5 0 Replication factor-A C terminal domain RWD PF05773.17 KOO30702.1 - 1.1e-05 25.2 0.0 2e-05 24.4 0.0 1.5 1 1 0 1 1 1 1 RWD domain HAD PF12710.2 KOO30704.1 - 2.5e-14 53.8 0.0 4.4e-13 49.8 0.0 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOO30704.1 - 6.4e-13 49.6 0.1 2.2e-05 24.9 0.0 3.5 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOO30704.1 - 8.8e-09 35.2 0.0 2e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit E1-E2_ATPase PF00122.15 KOO30704.1 - 4.6e-06 25.8 0.1 2.6e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.7 KOO30704.1 - 0.0002 20.9 0.0 0.026 14.1 0.0 2.7 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 KOO30704.1 - 0.0058 16.8 0.0 0.042 14.0 0.0 2.1 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase CytochromB561_N PF09786.4 KOO30704.1 - 0.41 9.0 0.1 0.61 8.4 0.1 1.2 1 0 0 1 1 1 0 Cytochrome B561, N terminal Phosphonate-bd PF12974.2 KOO30705.1 - 2.4e-07 30.3 0.0 3.9e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein NMT1_2 PF13379.1 KOO30705.1 - 5.9e-07 29.1 0.2 1.7e-06 27.6 0.1 1.7 1 1 0 1 1 1 1 NMT1-like family NMT1 PF09084.6 KOO30705.1 - 2.7e-06 27.1 0.0 3.6e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 NMT1/THI5 like SBP_bac_3 PF00497.15 KOO30705.1 - 2e-05 23.9 0.0 3.3e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 OpuAC PF04069.7 KOO30705.1 - 0.028 13.7 0.0 0.054 12.8 0.0 1.5 1 1 0 1 1 1 0 Substrate binding domain of ABC-type glycine betaine transport system PARP PF00644.15 KOO30706.1 - 2.4e-09 36.9 0.0 6.3e-09 35.5 0.0 1.6 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain WW PF00397.21 KOO30706.1 - 0.00014 21.6 6.5 0.0022 17.8 4.5 2.4 1 1 0 1 1 1 1 WW domain Ank PF00023.25 KOO30706.1 - 0.0033 17.1 0.0 0.0091 15.7 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeat CUE PF02845.11 KOO30706.1 - 0.0035 16.8 0.0 0.0077 15.6 0.0 1.5 1 0 0 1 1 1 1 CUE domain Ank_5 PF13857.1 KOO30706.1 - 0.0054 16.9 0.0 0.014 15.6 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO30706.1 - 0.0086 16.3 0.3 0.022 15.1 0.2 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) FmdE PF02663.9 KOO30706.1 - 0.21 11.5 2.6 4.5 7.1 0.0 3.2 3 1 0 3 3 3 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon Sdh_cyt PF01127.17 KOO30708.1 - 1.5e-17 63.5 3.5 1.9e-17 63.1 2.4 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit RRM_1 PF00076.17 KOO30709.1 - 2.6e-17 62.1 0.0 6.8e-11 41.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO30709.1 - 2.9e-15 55.9 0.0 4.5e-09 36.1 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO30709.1 - 3e-10 39.8 0.0 3.9e-08 33.0 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP PF00641.13 KOO30709.1 - 6.5e-05 21.9 1.9 0.0001 21.3 1.4 1.3 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Aldo_ket_red PF00248.16 KOO30711.1 - 3.1e-19 68.8 0.0 1.5e-18 66.6 0.0 1.7 1 1 1 2 2 2 1 Aldo/keto reductase family EMP70 PF02990.11 KOO30712.1 - 4e-86 289.5 34.8 5.2e-86 289.1 24.1 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 TMEM219 PF14940.1 KOO30712.1 - 0.01 14.9 0.7 0.019 14.0 0.5 1.3 1 0 0 1 1 1 0 Transmembrane 219 Fea1 PF07692.6 KOO30713.1 - 0.0018 17.1 0.1 0.0037 16.1 0.1 1.5 1 1 0 1 1 1 1 Low iron-inducible periplasmic protein FAM163 PF15069.1 KOO30713.1 - 0.098 13.2 0.9 0.18 12.3 0.6 1.3 1 0 0 1 1 1 0 FAM163 family LRR19-TM PF15176.1 KOO30713.1 - 0.17 11.6 0.4 0.37 10.4 0.3 1.5 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain DUF2413 PF10310.4 KOO30714.1 - 0.016 14.0 7.8 0.022 13.5 5.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) DUF572 PF04502.8 KOO30714.1 - 0.028 13.6 4.3 0.037 13.2 3.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) AvrE PF11725.3 KOO30714.1 - 0.046 10.7 5.1 0.051 10.6 3.5 1.0 1 0 0 1 1 1 0 Pathogenicity factor APG6 PF04111.7 KOO30714.1 - 0.15 11.0 10.5 0.21 10.6 7.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4615 PF15393.1 KOO30714.1 - 0.19 11.9 1.9 0.38 10.9 1.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4615) BOP1NT PF08145.7 KOO30714.1 - 0.41 10.3 2.3 0.57 9.8 1.6 1.1 1 0 0 1 1 1 0 BOP1NT (NUC169) domain PAT1 PF09770.4 KOO30714.1 - 0.41 8.8 11.2 0.48 8.6 7.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4557 PF15101.1 KOO30714.1 - 1.6 8.5 5.8 2.4 7.9 4.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) PCEMA1 PF07418.6 KOO30714.1 - 2.6 7.3 5.6 3.6 6.8 3.9 1.1 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 EMP70 PF02990.11 KOO30715.1 - 6.3e-53 180.0 0.0 7.5e-53 179.7 0.0 1.0 1 0 0 1 1 1 1 Endomembrane protein 70 Filamin PF00630.14 KOO30716.1 - 2e-07 31.4 0.0 0.019 15.5 0.0 2.8 3 0 0 3 3 3 2 Filamin/ABP280 repeat Usp PF00582.21 KOO30716.1 - 3.3 7.8 7.7 2.3 8.3 3.6 2.0 2 0 0 2 2 2 0 Universal stress protein family PDZ PF00595.19 KOO30718.1 - 0.00018 21.6 0.0 0.00033 20.7 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Fer2 PF00111.22 KOO30718.1 - 0.0011 18.6 1.5 0.0019 17.9 1.0 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain PDZ_2 PF13180.1 KOO30718.1 - 0.024 14.5 0.0 0.054 13.3 0.0 1.7 1 0 0 1 1 1 0 PDZ domain Filamin PF00630.14 KOO30719.1 - 0.0023 18.4 0.0 0.57 10.7 0.0 2.2 2 0 0 2 2 2 2 Filamin/ABP280 repeat Filamin PF00630.14 KOO30720.1 - 0.00095 19.6 0.0 0.0019 18.7 0.0 1.5 1 0 0 1 1 1 1 Filamin/ABP280 repeat YtkA PF13115.1 KOO30720.1 - 0.049 13.9 0.0 0.087 13.1 0.0 1.4 1 0 0 1 1 1 0 YtkA-like MFS_1 PF07690.11 KOO30722.1 - 3.3e-09 35.9 5.3 3.6e-09 35.8 3.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily FA_desaturase PF00487.19 KOO30722.1 - 0.17 11.2 5.2 0.21 11.0 3.6 1.0 1 0 0 1 1 1 0 Fatty acid desaturase YwiC PF14256.1 KOO30722.1 - 0.2 11.7 4.7 0.066 13.3 0.9 1.8 2 0 0 2 2 2 0 YwiC-like protein MFS_1 PF07690.11 KOO30723.1 - 1.1e-10 40.7 14.4 1.9e-10 39.9 10.0 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KOO30723.1 - 3.1e-06 26.0 0.5 4.4e-06 25.5 0.3 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter Mito_carr PF00153.22 KOO30724.1 - 1.4e-56 188.1 1.1 2.1e-19 69.0 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein PDEase_I PF00233.14 KOO30725.1 - 2e-16 60.4 0.0 2.8e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Peptidase_M35 PF02102.10 KOO30725.1 - 0.38 9.3 4.3 0.45 9.1 3.0 1.1 1 0 0 1 1 1 0 Deuterolysin metalloprotease (M35) family Allantoicase PF03561.10 KOO30728.1 - 9.1e-50 168.0 0.0 5.2e-41 139.6 0.0 2.2 2 0 0 2 2 2 2 Allantoicase repeat Invasin_D3 PF09134.5 KOO30730.1 - 0.003 17.4 0.7 0.14 12.0 0.1 3.7 3 0 0 3 3 3 1 Invasin, domain 3 PEGA PF08308.6 KOO30730.1 - 0.096 12.4 1.1 17 5.2 0.0 4.7 4 0 0 4 4 4 0 PEGA domain Yip1 PF04893.12 KOO30731.1 - 4.3e-13 49.1 9.3 5.8e-13 48.7 6.4 1.1 1 0 0 1 1 1 1 Yip1 domain TcpE PF12648.2 KOO30731.1 - 0.37 10.9 2.7 0.44 10.7 0.9 1.8 1 1 0 1 1 1 0 TcpE family zf-RING_2 PF13639.1 KOO30732.1 - 1.5e-10 40.7 7.0 2.2e-10 40.1 4.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KOO30732.1 - 5.9e-09 35.9 3.5 9.2e-09 35.2 2.5 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 KOO30732.1 - 7.5e-07 29.0 7.0 1.3e-06 28.3 4.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO30732.1 - 8e-07 28.6 6.2 1.2e-06 28.0 4.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.1 KOO30732.1 - 4.5e-06 26.1 5.4 6.5e-06 25.6 3.8 1.3 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.1 KOO30732.1 - 7.4e-06 25.5 4.9 1.2e-05 24.8 3.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO30732.1 - 0.00012 21.6 5.8 0.00018 21.1 4.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-UDP PF14569.1 KOO30732.1 - 0.00064 19.4 5.2 0.0012 18.5 3.6 1.4 1 0 0 1 1 1 1 Zinc-binding RING-finger SAP PF02037.22 KOO30732.1 - 0.0065 15.9 0.5 0.011 15.2 0.4 1.4 1 0 0 1 1 1 1 SAP domain zf-Apc11 PF12861.2 KOO30732.1 - 0.017 14.9 5.4 0.036 13.9 3.7 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING-like PF08746.6 KOO30732.1 - 0.035 14.0 9.6 0.058 13.4 6.7 1.4 1 0 0 1 1 1 0 RING-like domain PHD PF00628.24 KOO30732.1 - 0.17 11.6 6.8 0.26 11.0 4.7 1.3 1 0 0 1 1 1 0 PHD-finger Rtf2 PF04641.7 KOO30732.1 - 0.2 10.7 0.4 0.3 10.2 0.3 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger zf-HC5HC2H PF13771.1 KOO30732.1 - 0.38 10.9 3.8 0.14 12.3 0.8 1.6 1 1 1 2 2 2 0 PHD-like zinc-binding domain FANCL_C PF11793.3 KOO30732.1 - 2.1 8.3 8.6 28 4.7 6.0 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain Prok-RING_1 PF14446.1 KOO30732.1 - 3.3 7.5 12.2 1.8 8.3 4.2 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 DZR PF12773.2 KOO30732.1 - 3.5 7.5 7.6 26 4.7 5.3 2.1 1 1 0 1 1 1 0 Double zinc ribbon F-box-like PF12937.2 KOO30733.1 - 3.5 7.4 6.6 4.2 7.1 2.2 3.1 3 1 0 3 3 3 0 F-box-like Ribosomal_L25p PF01386.14 KOO30734.1 - 1.4e-09 37.9 0.0 2.1e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal L25p family Ribosomal_TL5_C PF14693.1 KOO30734.1 - 5.2e-05 23.3 0.0 8.6e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein TL5, C-terminal domain AAA_33 PF13671.1 KOO30736.1 - 1.4e-07 31.5 0.7 1.6e-07 31.2 0.5 1.1 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOO30736.1 - 0.00061 18.9 1.2 0.0012 17.9 0.9 1.4 1 1 1 2 2 2 1 Zeta toxin IBR PF01485.16 KOO30737.1 - 4.6e-07 29.6 14.4 5.7e-07 29.3 7.6 2.4 2 0 0 2 2 2 1 IBR domain Ank_2 PF12796.2 KOO30737.1 - 0.0036 17.6 0.1 0.0074 16.6 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO30737.1 - 0.021 15.0 0.5 0.27 11.5 0.1 2.3 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Ank PF00023.25 KOO30737.1 - 0.025 14.3 0.9 0.083 12.7 0.1 2.3 3 0 0 3 3 3 0 Ankyrin repeat Ank_3 PF13606.1 KOO30737.1 - 0.11 12.8 0.6 1.3 9.4 0.1 2.7 2 0 0 2 2 2 0 Ankyrin repeat Tic22 PF04278.7 KOO30739.1 - 1e-10 41.3 0.0 2.8e-10 39.9 0.0 1.6 1 1 0 1 1 1 1 Tic22-like family Hint PF01079.15 KOO30740.1 - 0.00056 19.1 0.0 0.00077 18.7 0.0 1.1 1 0 0 1 1 1 1 Hint module Sel1 PF08238.7 KOO30742.1 - 6.3e-12 45.7 10.4 3.7e-05 24.2 2.0 3.7 3 0 0 3 3 3 3 Sel1 repeat U-box PF04564.10 KOO30742.1 - 1.5e-05 24.8 0.0 3.4e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO30742.1 - 0.0012 18.3 0.0 0.0022 17.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Nucleoporin_FG PF13634.1 KOO30744.1 - 0.071 13.3 14.4 0.15 12.3 10.0 1.6 1 0 0 1 1 1 0 Nucleoporin FG repeat region NUP50 PF08911.6 KOO30745.1 - 8e-13 48.5 0.3 8e-13 48.5 0.2 2.9 2 1 0 2 2 2 1 NUP50 (Nucleoporin 50 kDa) Cupin_8 PF13621.1 KOO30746.1 - 1.7e-34 119.4 0.0 2e-34 119.2 0.0 1.0 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.17 KOO30746.1 - 0.086 13.0 0.0 0.27 11.4 0.0 1.8 1 1 0 1 1 1 0 JmjC domain, hydroxylase TPR_16 PF13432.1 KOO30747.1 - 1.7e-06 28.5 15.0 0.1 13.2 0.7 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 KOO30747.1 - 0.00017 21.1 8.5 0.34 10.5 0.1 3.2 2 1 1 3 3 3 2 TPR repeat RPN7 PF10602.4 KOO30747.1 - 0.03 13.7 0.4 0.055 12.8 0.2 1.4 1 0 0 1 1 1 0 26S proteasome subunit RPN7 TPR_19 PF14559.1 KOO30747.1 - 0.17 12.2 14.2 0.31 11.4 1.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO30747.1 - 0.36 11.5 15.3 1.6 9.5 0.9 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO30747.1 - 0.88 9.6 15.8 0.27 11.2 2.0 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOO30747.1 - 4.3 7.1 8.5 7.5 6.3 0.2 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO30747.1 - 4.8 7.1 14.6 8.4 6.4 5.5 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat GSIII_N PF12437.3 KOO30748.1 - 8.6e-51 171.5 0.1 5.3e-50 169.0 0.0 2.1 2 0 0 2 2 2 1 Glutamine synthetase type III N terminal Gln-synt_C PF00120.19 KOO30748.1 - 1.8e-28 99.3 0.0 4e-28 98.2 0.0 1.5 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain DAGK_acc PF00609.14 KOO30749.1 - 4e-38 131.0 0.0 1e-37 129.7 0.0 1.7 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.19 KOO30749.1 - 3.8e-19 68.4 0.0 9.8e-19 67.0 0.0 1.7 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain V-ATPase_H_N PF03224.9 KOO30749.1 - 8.4e-06 25.1 2.8 0.019 14.1 0.2 2.3 1 1 0 2 2 2 2 V-ATPase subunit H Arm PF00514.18 KOO30749.1 - 0.00026 20.7 11.8 2.3 8.1 0.4 5.6 5 0 0 5 5 5 3 Armadillo/beta-catenin-like repeat Pedibin PF08182.6 KOO30749.1 - 0.67 9.5 2.5 56 3.3 0.0 4.3 5 0 0 5 5 5 0 Pedibin/Hym-346 family EF-hand_5 PF13202.1 KOO30750.1 - 7.2e-06 25.1 0.0 1.4e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 EF hand Arm PF00514.18 KOO30750.1 - 3.5e-05 23.4 4.6 0.046 13.5 0.1 3.6 3 1 1 4 4 4 2 Armadillo/beta-catenin-like repeat EF-hand_1 PF00036.27 KOO30750.1 - 0.00012 21.1 0.0 0.00025 20.1 0.0 1.5 1 0 0 1 1 1 1 EF hand V-ATPase_H_N PF03224.9 KOO30750.1 - 0.00061 18.9 1.0 0.00082 18.5 0.7 1.2 1 0 0 1 1 1 1 V-ATPase subunit H EF-hand_7 PF13499.1 KOO30750.1 - 0.0022 18.1 0.1 0.012 15.7 0.0 2.2 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO30750.1 - 0.0035 17.0 0.1 0.0097 15.7 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain Arm_2 PF04826.8 KOO30750.1 - 0.0073 15.4 0.2 2.2 7.3 0.0 2.2 1 1 1 2 2 2 2 Armadillo-like EF-hand_8 PF13833.1 KOO30750.1 - 0.013 15.1 0.0 0.039 13.5 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain pair PP-binding_2 PF14573.1 KOO30750.1 - 0.031 14.3 0.1 0.063 13.3 0.0 1.5 1 0 0 1 1 1 0 Acyl-carrier HEAT_2 PF13646.1 KOO30750.1 - 0.053 13.8 4.4 1 9.7 0.2 2.7 1 1 1 2 2 2 0 HEAT repeats EF-hand_7 PF13499.1 KOO30751.1 - 4e-13 49.2 2.3 4.9e-13 49.0 0.3 2.1 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO30751.1 - 4.3e-13 47.5 1.2 6.9e-06 25.0 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO30751.1 - 7.2e-12 44.0 1.9 3.6e-06 26.0 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO30751.1 - 1.1e-11 43.5 0.4 6.2e-06 25.6 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO30751.1 - 5.7e-10 38.6 0.7 1.7e-09 37.1 0.1 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.1 KOO30751.1 - 4.7e-05 23.2 0.0 0.0001 22.1 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.2 KOO30751.1 - 0.0041 16.8 0.1 0.0081 15.8 0.1 1.4 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO30751.1 - 0.016 15.2 0.0 0.016 15.2 0.0 2.6 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DLD PF14878.1 KOO30751.1 - 0.16 12.0 2.7 0.24 11.4 0.0 2.3 1 1 2 3 3 3 0 Death-like domain of SPT6 RR_TM4-6 PF06459.7 KOO30751.1 - 0.27 11.0 6.0 0.35 10.7 4.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PSD4 PF07631.6 KOO30751.1 - 0.82 10.0 6.4 1.7 9.0 3.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1592) VIT1 PF01988.14 KOO30751.1 - 2.3 7.6 3.7 3.9 6.8 2.6 1.3 1 0 0 1 1 1 0 VIT family Pkinase PF00069.20 KOO30752.1 - 3.6e-36 124.6 0.0 3.9e-24 85.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO30752.1 - 8e-31 107.0 0.0 5.8e-23 81.2 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase EF-hand_1 PF00036.27 KOO30752.1 - 3.3e-11 41.6 0.5 5.8e-05 22.1 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO30752.1 - 1.5e-09 37.8 0.7 3e-09 36.8 0.5 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO30752.1 - 1.7e-08 33.4 0.6 5e-05 22.4 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO30752.1 - 5.1e-08 32.1 0.1 0.0006 19.4 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO30752.1 - 9e-05 22.0 2.8 0.065 12.8 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain pair PDZ_2 PF13180.1 KOO30752.1 - 0.073 12.9 0.4 0.19 11.6 0.3 1.6 1 0 0 1 1 1 0 PDZ domain EF-hand_9 PF14658.1 KOO30752.1 - 0.087 12.7 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain Borrelia_P83 PF05262.6 KOO30752.1 - 0.61 8.2 4.9 9.8 4.3 3.2 2.0 2 0 0 2 2 2 0 Borrelia P83/100 protein Myb_DNA-binding PF00249.26 KOO30753.1 - 4.3e-25 87.4 1.0 7.8e-15 54.6 0.2 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO30753.1 - 7.8e-20 70.7 1.0 4.8e-15 55.4 0.1 2.5 1 1 1 2 2 2 2 Myb-like DNA-binding domain DUF268 PF03269.9 KOO30753.1 - 8e-06 25.5 0.0 1.4e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Caenorhabditis protein of unknown function, DUF268 Myb_DNA-bind_4 PF13837.1 KOO30753.1 - 2.8 8.1 5.8 15 5.7 1.2 3.1 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain Ank_2 PF12796.2 KOO30754.1 - 3.7e-39 132.9 5.9 1.1e-15 57.7 0.2 4.8 4 1 1 5 5 5 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO30754.1 - 3.2e-30 102.4 13.4 9.5e-08 31.4 0.1 7.7 7 1 0 7 7 7 5 Ankyrin repeat Ank_4 PF13637.1 KOO30754.1 - 2.9e-26 91.3 2.9 1.2e-06 28.8 0.0 6.4 4 2 3 7 7 7 6 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO30754.1 - 1.1e-21 76.3 7.2 0.00058 20.0 0.0 5.9 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO30754.1 - 3.4e-20 70.0 2.5 9.2e-05 22.3 0.0 5.9 5 0 0 5 5 5 3 Ankyrin repeat Lin0512_fam PF09585.5 KOO30755.1 - 4.4e-09 35.9 0.0 7.3e-09 35.2 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein (Lin0512_fam) Sel1 PF08238.7 KOO30757.1 - 2.5e-18 66.0 3.4 6.3e-05 23.4 0.0 3.4 3 0 0 3 3 3 3 Sel1 repeat DUF1199 PF06712.6 KOO30757.1 - 0.27 11.0 0.1 0.27 11.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1199) TPT PF03151.11 KOO30758.1 - 2.3e-22 79.2 10.3 3e-22 78.9 1.3 2.3 2 0 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.15 KOO30758.1 - 2.2e-15 56.8 23.0 1.4e-09 38.0 4.2 2.9 3 0 0 3 3 3 2 EamA-like transporter family 7TM_GPCR_Srt PF10321.4 KOO30758.1 - 0.008 14.9 0.1 0.013 14.3 0.0 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srt EmrE PF13536.1 KOO30758.1 - 0.01 15.9 4.4 0.01 15.9 3.0 3.5 3 1 1 4 4 4 0 Multidrug resistance efflux transporter NT-C2 PF10358.4 KOO30759.1 - 0.00051 19.5 0.1 5.1 6.5 0.0 4.8 5 0 0 5 5 5 2 N-terminal C2 in EEIG1 and EHBP1 proteins Glyco_hydro_31 PF01055.21 KOO30760.1 - 5.6e-76 256.1 3.5 1.9e-74 251.0 2.4 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 PAN_4 PF14295.1 KOO30760.1 - 1e-07 31.5 2.7 1e-07 31.5 1.8 1.9 2 0 0 2 2 2 1 PAN domain PAN_1 PF00024.21 KOO30760.1 - 0.006 16.3 0.2 0.012 15.3 0.1 1.5 1 0 0 1 1 1 1 PAN domain Pkinase PF00069.20 KOO30761.1 - 5.4e-41 140.4 0.0 7.6e-41 139.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO30761.1 - 6.7e-16 58.1 0.0 1e-15 57.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO30761.1 - 0.12 11.2 0.1 0.32 9.9 0.1 1.6 1 1 0 1 1 1 0 Kinase-like RabGAP-TBC PF00566.13 KOO30762.1 - 4.9e-47 160.1 0.0 6.6e-47 159.7 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain LRR_6 PF13516.1 KOO30765.1 - 8.7e-14 50.0 0.2 0.0029 17.5 0.0 6.1 6 0 0 6 6 6 3 Leucine Rich repeat LRR_4 PF12799.2 KOO30765.1 - 1.7e-06 27.4 0.0 0.68 9.6 0.0 4.7 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO30765.1 - 5.1e-06 25.8 0.0 11 6.5 0.0 5.8 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_7 PF13504.1 KOO30765.1 - 2.4e-05 23.7 3.0 21 5.9 0.0 6.1 6 0 0 6 6 6 1 Leucine rich repeat LRR_8 PF13855.1 KOO30765.1 - 0.0039 16.9 3.5 10 5.9 0.0 4.9 4 1 1 5 5 5 1 Leucine rich repeat VWA PF00092.23 KOO30766.1 - 1.6e-19 70.3 0.0 1.8e-19 70.1 0.0 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.1 KOO30766.1 - 1.7e-16 60.7 3.1 1.9e-16 60.6 2.1 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.9 KOO30766.1 - 0.00025 20.2 0.1 0.0003 20.0 0.1 1.2 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein DUF1194 PF06707.6 KOO30766.1 - 0.0017 17.3 0.4 0.0022 17.0 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1194) VWA_3 PF13768.1 KOO30766.1 - 0.022 14.4 0.0 0.029 14.0 0.0 1.1 1 0 0 1 1 1 0 von Willebrand factor type A domain Pkinase PF00069.20 KOO30769.1 - 5e-36 124.1 0.0 7.3e-36 123.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO30769.1 - 5.7e-35 120.6 0.0 7.4e-35 120.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PP2C PF00481.16 KOO30769.1 - 2.2e-26 92.8 0.0 3.6e-26 92.1 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOO30769.1 - 4e-06 26.6 0.7 6.2e-05 22.7 0.5 2.2 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 KOO30769.1 - 2e-05 24.1 0.3 0.00011 21.6 0.2 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C PH PF00169.24 KOO30770.1 - 4.8e-10 39.5 0.0 7.5e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 PH domain PDZ PF00595.19 KOO30770.1 - 2.4e-05 24.4 0.4 5.6e-05 23.2 0.3 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Tricorn_PDZ PF14685.1 KOO30770.1 - 0.0028 17.4 1.2 0.0052 16.5 0.3 2.0 2 1 0 2 2 2 1 Tricorn protease PDZ domain PDZ_2 PF13180.1 KOO30770.1 - 0.003 17.3 0.4 0.0067 16.2 0.2 1.6 1 1 0 1 1 1 1 PDZ domain TrmE_N PF10396.4 KOO30771.1 - 5.5e-26 90.7 0.0 1.2e-25 89.6 0.0 1.6 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus GTPase_Cys_C PF12631.2 KOO30771.1 - 2.5e-25 88.6 1.1 1.9e-24 85.8 0.3 2.6 3 0 0 3 3 3 1 Catalytic cysteine-containing C-terminus of GTPase, MnmE MMR_HSR1 PF01926.18 KOO30771.1 - 1.1e-17 64.0 0.0 2e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 KOO30771.1 - 2.3e-05 24.2 0.0 3.9e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Dynamin family FeoB_N PF02421.13 KOO30771.1 - 0.00028 20.1 0.0 0.00046 19.4 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.22 KOO30771.1 - 0.0012 19.1 0.0 0.0045 17.2 0.0 1.8 1 1 1 2 2 2 1 ABC transporter Miro PF08477.8 KOO30771.1 - 0.0016 18.9 0.0 0.0031 17.9 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein AAA_17 PF13207.1 KOO30771.1 - 0.0039 17.9 0.0 0.022 15.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.1 KOO30771.1 - 0.014 15.4 0.0 0.031 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Arf PF00025.16 KOO30771.1 - 0.015 14.5 0.0 0.076 12.2 0.0 2.0 2 0 0 2 2 2 0 ADP-ribosylation factor family DUF258 PF03193.11 KOO30771.1 - 0.016 14.3 0.0 0.032 13.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_10 PF12846.2 KOO30771.1 - 0.074 12.4 0.1 1.3 8.3 0.0 2.4 3 0 0 3 3 3 0 AAA-like domain CRAL_TRIO PF00650.15 KOO30773.1 - 2.9e-14 52.8 0.0 4.2e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain A2M_N PF01835.14 KOO30774.1 - 0.087 13.0 0.0 1.1 9.5 0.0 2.4 2 0 0 2 2 2 0 MG2 domain GUN4 PF05419.7 KOO30775.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 GUN4-like zf-C2H2_2 PF12756.2 KOO30778.1 - 3.4e-21 75.2 0.0 7.5e-19 67.7 0.1 2.3 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 KOO30778.1 - 0.02 15.0 7.7 0.4 10.9 0.3 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding 2OG-FeII_Oxy_3 PF13640.1 KOO30779.1 - 1.4e-13 51.1 0.1 4.8e-13 49.4 0.1 1.9 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO30779.1 - 0.00099 18.7 3.2 0.0038 16.8 0.4 2.7 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.1 KOO30779.1 - 0.021 15.0 0.4 0.056 13.7 0.0 2.0 2 0 0 2 2 2 0 Putative 2OG-Fe(II) oxygenase PhyH PF05721.8 KOO30779.1 - 0.036 14.1 0.0 0.26 11.2 0.0 2.2 2 0 0 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) PABP PF00658.13 KOO30780.1 - 1e-07 31.5 0.6 2.9e-07 30.0 0.0 2.0 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain Kinesin PF00225.18 KOO30781.1 - 1.2e-47 162.2 0.0 3.1e-47 160.9 0.0 1.4 1 1 0 1 1 1 1 Kinesin motor domain AAA_22 PF13401.1 KOO30781.1 - 0.0023 18.0 0.1 0.0065 16.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 KOO30781.1 - 0.0036 16.9 0.0 0.0064 16.1 0.0 1.4 1 0 0 1 1 1 1 NACHT domain T2SE PF00437.15 KOO30781.1 - 0.0049 15.8 0.0 0.0087 14.9 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein DAP3 PF10236.4 KOO30781.1 - 0.011 14.6 0.1 0.018 13.9 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Mg_chelatase PF01078.16 KOO30781.1 - 0.031 13.4 0.1 0.06 12.5 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_16 PF13191.1 KOO30781.1 - 0.032 14.2 1.6 0.064 13.2 0.7 2.0 1 1 0 2 2 2 0 AAA ATPase domain CbiA PF01656.18 KOO30781.1 - 0.045 13.1 0.1 0.1 11.9 0.1 1.6 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain RNA_helicase PF00910.17 KOO30781.1 - 0.072 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 RNA helicase ResIII PF04851.10 KOO30781.1 - 0.098 12.4 0.1 0.15 11.8 0.1 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit IQ PF00612.22 KOO30782.1 - 0.11 12.1 5.8 0.26 11.0 0.4 3.3 3 0 0 3 3 3 0 IQ calmodulin-binding motif NusA_N PF08529.6 KOO30783.1 - 0.0033 17.4 0.2 0.01 15.8 0.2 1.8 1 0 0 1 1 1 1 NusA N-terminal domain DUF892 PF05974.7 KOO30783.1 - 0.0068 16.2 4.0 0.026 14.3 0.1 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF892) YxiJ PF14176.1 KOO30783.1 - 0.034 14.2 0.3 0.08 13.0 0.2 1.6 1 0 0 1 1 1 0 YxiJ-like protein LRR_6 PF13516.1 KOO30785.1 - 8.9e-44 142.6 3.0 0.00029 20.5 0.0 9.6 9 0 0 9 9 9 9 Leucine Rich repeat LRR_4 PF12799.2 KOO30785.1 - 1.9e-08 33.7 4.0 0.027 14.1 0.0 6.2 3 3 3 7 7 7 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO30785.1 - 8.6e-06 25.0 0.0 43 4.7 0.0 7.3 9 0 0 9 9 9 0 Leucine Rich Repeat LRR_7 PF13504.1 KOO30785.1 - 0.00031 20.4 2.0 1.7e+02 3.1 0.0 7.4 9 0 0 9 9 9 0 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO30785.1 - 0.0005 20.1 3.9 1.1 9.4 0.0 5.1 3 1 3 6 6 6 1 RNA 2'-O ribose methyltransferase substrate binding LRR_8 PF13855.1 KOO30785.1 - 0.00093 18.8 0.3 6.1 6.6 0.0 5.1 3 2 4 7 7 7 1 Leucine rich repeat YycC PF14174.1 KOO30785.1 - 0.11 12.1 0.0 2.2e+02 1.5 0.0 5.1 7 0 0 7 7 7 0 YycC-like protein DUF2202 PF09968.4 KOO30785.1 - 0.29 10.7 1.6 22 4.6 0.0 3.5 1 1 1 3 3 3 0 Uncharacterized protein domain (DUF2202) CbiG_N PF11760.3 KOO30785.1 - 4.4 7.0 25.6 13 5.5 0.0 7.0 5 3 1 6 6 6 0 Cobalamin synthesis G N-terminal RRM_1 PF00076.17 KOO30786.1 - 5.2e-20 70.8 0.0 1.1e-13 50.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO30786.1 - 4.9e-18 64.8 0.0 1.7e-12 47.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO30786.1 - 3.2e-05 23.6 0.0 0.00023 20.9 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4283 PF14111.1 KOO30786.1 - 0.071 12.1 0.0 0.2 10.7 0.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4283) EF-hand_1 PF00036.27 KOO30787.1 - 2.9e-18 63.7 7.3 8.4e-05 21.5 0.1 5.4 5 0 0 5 5 5 4 EF hand DnaJ PF00226.26 KOO30787.1 - 7.7e-17 60.7 2.5 1.8e-16 59.6 1.7 1.6 1 0 0 1 1 1 1 DnaJ domain EF-hand_6 PF13405.1 KOO30787.1 - 6.4e-16 56.7 6.4 0.0028 17.4 0.0 5.9 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.1 KOO30787.1 - 5.9e-14 51.4 3.8 4.3e-07 29.4 0.1 3.3 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.1 KOO30787.1 - 3.3e-13 49.5 8.9 6.3e-07 29.4 1.6 4.4 2 1 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO30787.1 - 2.4e-10 39.2 3.5 4.6e-05 22.5 0.0 3.8 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.4 KOO30787.1 - 0.057 13.4 1.3 2.2 8.3 0.0 3.5 2 2 3 5 5 5 0 Secreted protein acidic and rich in cysteine Ca binding region CTC1 PF15489.1 KOO30788.1 - 0.26 8.5 0.0 0.48 7.7 0.0 1.3 1 0 0 1 1 1 0 CST, telomere maintenance, complex subunit CTC1 Miro PF08477.8 KOO30789.1 - 1.1e-05 25.9 0.0 0.25 11.8 0.0 2.5 2 0 0 2 2 2 2 Miro-like protein Ank_5 PF13857.1 KOO30789.1 - 1.1e-05 25.4 0.1 4.8e-05 23.4 0.1 2.2 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ras PF00071.17 KOO30789.1 - 0.0032 16.8 0.0 2.2 7.6 0.0 2.3 2 0 0 2 2 2 2 Ras family Ank PF00023.25 KOO30789.1 - 0.0067 16.1 0.2 0.023 14.5 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.1 KOO30789.1 - 0.056 13.7 0.0 0.21 11.9 0.0 2.1 1 0 0 1 1 1 0 Ankyrin repeat TIR PF01582.15 KOO30789.1 - 0.37 10.2 0.0 0.7 9.3 0.0 1.4 1 0 0 1 1 1 0 TIR domain zf-U1 PF06220.7 KOO30790.1 - 3.6e-08 32.8 0.2 7.6e-08 31.7 0.2 1.5 1 0 0 1 1 1 1 U1 zinc finger Herpes_UL25 PF01499.11 KOO30790.1 - 0.027 12.7 3.2 0.03 12.6 2.2 1.0 1 0 0 1 1 1 0 Herpesvirus UL25 family zf-Dof PF02701.10 KOO30790.1 - 0.16 11.9 0.4 0.27 11.1 0.3 1.4 1 0 0 1 1 1 0 Dof domain, zinc finger zf-C2H2_jaz PF12171.3 KOO30790.1 - 0.48 10.6 7.2 3.4 7.9 5.0 2.1 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding G-patch PF01585.18 KOO30791.1 - 1.1e-14 53.8 4.5 2.4e-14 52.8 3.1 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 KOO30791.1 - 8e-11 41.6 1.2 8e-11 41.6 0.8 2.2 3 0 0 3 3 3 1 DExH-box splicing factor binding site Nha1_C PF08619.5 KOO30791.1 - 5.5 6.1 15.6 0.048 12.9 2.3 2.1 2 0 0 2 2 2 0 Alkali metal cation/H+ antiporter Nha1 C terminus zf-PARP PF00645.13 KOO30792.1 - 5.1e-33 113.1 1.8 8.1e-18 64.4 0.0 2.4 2 0 0 2 2 2 2 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region ART PF01129.13 KOO30792.1 - 3.8e-11 42.5 0.0 6.6e-11 41.7 0.0 1.3 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase WGR PF05406.10 KOO30792.1 - 4.2e-11 42.6 0.2 1.1e-10 41.2 0.1 1.7 1 0 0 1 1 1 1 WGR domain SAP PF02037.22 KOO30792.1 - 5.5e-08 32.1 0.8 1.6e-07 30.6 0.6 1.9 1 0 0 1 1 1 1 SAP domain ADPrib_exo_Tox PF03496.9 KOO30792.1 - 1.2e-06 27.8 0.0 5.2e-06 25.7 0.0 1.9 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme PARP_reg PF02877.9 KOO30792.1 - 4.7e-06 26.3 0.0 8.5e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain BORA_N PF15280.1 KOO30792.1 - 0.0052 16.1 0.2 0.0092 15.3 0.1 1.3 1 0 0 1 1 1 1 Protein aurora borealis N-terminus TF_Zn_Ribbon PF08271.7 KOO30792.1 - 0.13 11.6 0.7 7.1 6.0 0.1 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding Mid2 PF04478.7 KOO30793.1 - 0.0075 15.6 1.5 0.013 14.9 1.1 1.5 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor Herpes_gE PF02480.11 KOO30793.1 - 0.0086 14.3 2.5 0.012 13.9 1.7 1.2 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E Adeno_E3_CR2 PF02439.10 KOO30793.1 - 0.021 14.3 3.4 0.021 14.3 2.4 2.1 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 DHquinase_II PF01220.14 KOO30793.1 - 0.04 13.2 0.2 0.064 12.5 0.1 1.4 1 0 0 1 1 1 0 Dehydroquinase class II Syndecan PF01034.15 KOO30793.1 - 0.058 13.0 1.4 0.13 11.8 0.9 1.5 1 0 0 1 1 1 0 Syndecan domain TraL PF07178.6 KOO30793.1 - 0.16 11.9 0.5 0.32 11.0 0.3 1.4 1 0 0 1 1 1 0 TraL protein Shisa PF13908.1 KOO30793.1 - 0.19 11.8 9.4 0.047 13.8 3.2 1.9 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator DUF3816 PF12822.2 KOO30793.1 - 0.2 11.5 5.1 0.41 10.5 3.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3816) DUF3481 PF11980.3 KOO30793.1 - 0.82 9.5 3.4 0.85 9.4 1.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3481) SNAP PF14938.1 KOO30794.1 - 2.2e-100 335.4 26.9 2.5e-100 335.2 18.6 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 KOO30794.1 - 9.2e-08 31.9 22.2 3.5e-06 26.8 3.4 4.1 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.1 KOO30794.1 - 6e-07 28.7 21.2 0.11 12.3 0.9 6.6 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.1 KOO30794.1 - 1.5e-06 28.2 22.8 0.13 12.8 0.7 6.7 5 1 1 7 7 6 4 Tetratricopeptide repeat TPR_16 PF13432.1 KOO30794.1 - 2.2e-06 28.2 23.9 0.0033 18.0 4.9 4.5 2 1 1 4 4 4 3 Tetratricopeptide repeat TRAPPC-Trs85 PF12739.2 KOO30794.1 - 6.9e-05 21.6 10.8 8e-05 21.4 7.0 1.4 1 1 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TPR_11 PF13414.1 KOO30794.1 - 0.00011 21.7 25.3 0.067 12.8 5.8 4.7 2 2 3 5 5 5 2 TPR repeat SAC3_GANP PF03399.11 KOO30794.1 - 0.00077 19.0 0.2 0.0058 16.2 0.2 2.4 1 1 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family TPR_19 PF14559.1 KOO30794.1 - 0.0023 18.2 16.6 4.6 7.6 0.1 4.9 1 1 2 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.1 KOO30794.1 - 0.0036 17.1 11.3 2.4 8.2 0.0 4.9 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO30794.1 - 0.005 17.3 17.6 1.7 9.4 1.0 6.4 4 1 3 7 7 7 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO30794.1 - 0.011 15.4 3.1 0.011 15.4 2.2 6.3 4 1 1 6 6 6 0 Tetratricopeptide repeat NSF PF02071.15 KOO30794.1 - 0.013 15.8 31.7 7.7 7.5 0.1 8.4 6 2 2 8 8 8 0 Aromatic-di-Alanine (AdAR) repeat VWA PF00092.23 KOO30794.1 - 0.027 14.2 0.1 0.051 13.3 0.1 1.5 1 0 0 1 1 1 0 von Willebrand factor type A domain RPN7 PF10602.4 KOO30794.1 - 0.082 12.2 9.8 0.034 13.5 1.1 3.4 1 1 3 4 4 4 0 26S proteasome subunit RPN7 TPR_2 PF07719.12 KOO30794.1 - 0.21 11.6 35.6 0.049 13.5 3.0 7.1 6 2 3 9 9 7 0 Tetratricopeptide repeat Foie-gras_1 PF11817.3 KOO30794.1 - 0.25 10.7 7.9 0.23 10.9 0.9 2.6 2 1 0 2 2 2 0 Foie gras liver health family 1 TPR_1 PF00515.23 KOO30794.1 - 0.69 9.6 28.5 0.15 11.7 2.6 6.1 6 1 1 7 7 6 0 Tetratricopeptide repeat Sel1 PF08238.7 KOO30794.1 - 0.74 10.5 0.1 0.74 10.5 0.1 4.3 5 0 0 5 5 4 0 Sel1 repeat DUF2225 PF09986.4 KOO30794.1 - 5.3 6.4 15.3 2.6e+02 0.9 10.6 2.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) MIT PF04212.13 KOO30794.1 - 6.3 6.7 26.3 1.8 8.4 2.1 5.4 3 3 1 4 4 4 0 MIT (microtubule interacting and transport) domain HEAT_2 PF13646.1 KOO30795.1 - 3.5e-45 152.2 21.5 9.1e-12 45.0 0.0 6.2 3 2 3 6 6 6 5 HEAT repeats HEAT PF02985.17 KOO30795.1 - 1.5e-36 121.1 18.2 0.00025 20.8 0.0 11.6 10 1 1 11 11 11 9 HEAT repeat HEAT_EZ PF13513.1 KOO30795.1 - 2.1e-24 85.2 24.9 0.00051 20.4 0.1 10.3 7 4 4 11 11 11 9 HEAT-like repeat ART PF01129.13 KOO30795.1 - 8.8e-12 44.5 0.0 1.7e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase PARP_reg PF02877.9 KOO30795.1 - 8e-11 41.7 0.0 1.9e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.10 KOO30795.1 - 4.2e-09 36.2 0.1 9e-09 35.1 0.0 1.5 1 0 0 1 1 1 1 WGR domain SAP PF02037.22 KOO30795.1 - 2.7e-08 33.1 0.3 2.7e-08 33.1 0.2 3.9 5 0 0 5 5 5 1 SAP domain Cnd1 PF12717.2 KOO30795.1 - 7.1e-05 22.7 0.1 29 4.4 0.0 5.8 1 1 4 6 6 6 0 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.15 KOO30795.1 - 0.00065 18.1 0.0 0.013 13.8 0.0 2.2 1 1 0 1 1 1 1 Adaptin N terminal region DUF2120 PF09893.4 KOO30795.1 - 0.0027 17.6 0.1 31 4.4 0.0 4.5 1 1 2 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2120) Arm PF00514.18 KOO30795.1 - 0.011 15.5 5.2 7.1 6.6 0.0 5.3 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat DNA_alkylation PF08713.6 KOO30795.1 - 0.029 13.8 0.1 15 4.9 0.0 4.0 3 1 1 5 5 5 0 DNA alkylation repair enzyme ADPrib_exo_Tox PF03496.9 KOO30795.1 - 0.047 12.8 0.1 0.2 10.8 0.0 1.9 2 0 0 2 2 2 0 ADP-ribosyltransferase exoenzyme ATP_bind_1 PF03029.12 KOO30795.1 - 0.12 11.9 0.0 49 3.3 0.0 3.2 1 1 0 3 3 3 0 Conserved hypothetical ATP binding protein HEAT_PBS PF03130.11 KOO30795.1 - 0.22 12.0 34.9 14 6.4 0.0 9.3 10 0 0 10 10 8 0 PBS lyase HEAT-like repeat EF-hand_1 PF00036.27 KOO30796.1 - 8.2e-23 77.9 3.2 0.00021 20.3 0.1 5.6 5 0 0 5 5 5 5 EF hand EF-hand_7 PF13499.1 KOO30796.1 - 5.5e-20 71.2 8.2 7.2e-08 32.4 0.0 4.4 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO30796.1 - 6.9e-20 69.1 10.5 0.00049 19.7 0.2 5.7 5 0 0 5 5 5 5 EF-hand domain EF-hand_5 PF13202.1 KOO30796.1 - 6.9e-19 66.2 12.0 0.0016 17.7 0.1 5.6 5 0 0 5 5 5 5 EF hand EF-hand_8 PF13833.1 KOO30796.1 - 1.9e-09 37.0 7.6 0.00022 20.7 0.4 5.2 3 1 1 4 4 4 3 EF-hand domain pair Amidohydro_2 PF04909.9 KOO30796.1 - 0.00013 21.6 0.5 0.00013 21.6 0.3 2.6 3 1 0 3 3 3 1 Amidohydrolase SPARC_Ca_bdg PF10591.4 KOO30796.1 - 0.002 18.1 0.1 1.1 9.2 0.0 3.4 3 1 1 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region GSP_synth PF03738.9 KOO30796.1 - 0.021 15.0 0.2 0.051 13.8 0.1 1.6 1 0 0 1 1 1 0 Glutathionylspermidine synthase preATP-grasp Spc7 PF08317.6 KOO30801.1 - 0.89 8.1 15.1 2.3 6.8 0.5 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein ERM PF00769.14 KOO30801.1 - 2.2 7.7 29.2 0.45 10.0 11.7 2.4 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Ras PF00071.17 KOO30802.1 - 2.5e-61 205.7 2.0 3.1e-61 205.4 1.4 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO30802.1 - 7.8e-21 74.7 0.2 1.4e-20 74.0 0.1 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO30802.1 - 2.5e-15 56.1 0.1 3.2e-15 55.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 KOO30802.1 - 2.8e-07 30.4 0.3 6.1e-07 29.4 0.2 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 KOO30802.1 - 7.5e-07 28.7 0.9 3.9e-06 26.4 0.6 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 KOO30802.1 - 0.00016 20.8 0.1 0.00021 20.5 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 KOO30802.1 - 0.00029 20.1 0.1 0.00044 19.5 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.1 KOO30802.1 - 0.0014 18.7 0.1 0.0033 17.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 KOO30802.1 - 0.0034 16.5 0.2 0.0052 15.9 0.2 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_15 PF13175.1 KOO30802.1 - 0.0045 16.0 0.2 0.0062 15.6 0.1 1.2 1 0 0 1 1 1 1 AAA ATPase domain FA_synthesis PF02504.10 KOO30802.1 - 0.0049 15.7 1.3 0.0073 15.2 0.9 1.2 1 0 0 1 1 1 1 Fatty acid synthesis protein AAA_16 PF13191.1 KOO30802.1 - 0.024 14.6 0.2 0.045 13.7 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain Septin PF00735.13 KOO30802.1 - 0.025 13.5 0.0 0.061 12.3 0.0 1.6 1 0 0 1 1 1 0 Septin ABC_tran PF00005.22 KOO30802.1 - 0.029 14.6 0.2 0.047 13.9 0.1 1.5 1 1 0 1 1 1 0 ABC transporter MobB PF03205.9 KOO30802.1 - 0.041 13.5 0.5 0.24 11.1 0.3 2.1 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_24 PF13479.1 KOO30802.1 - 0.041 13.4 0.1 0.072 12.6 0.1 1.5 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.4 KOO30802.1 - 0.051 13.0 0.2 0.36 10.3 0.1 2.4 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.1 KOO30802.1 - 0.051 13.4 0.0 0.091 12.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 KOO30802.1 - 0.09 12.4 0.1 0.14 11.8 0.1 1.3 1 0 0 1 1 1 0 Archaeal ATPase DUF4265 PF14085.1 KOO30802.1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4265) SAC3_GANP PF03399.11 KOO30803.1 - 2.2e-25 89.4 0.0 3.2e-25 88.9 0.0 1.2 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI_Csn8 PF10075.4 KOO30803.1 - 0.11 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 COP9 signalosome, subunit CSN8 DSPc PF00782.15 KOO30804.1 - 1e-24 86.5 0.0 1.4e-24 86.1 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KOO30804.1 - 0.0063 15.8 0.0 0.0089 15.3 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Acyl-CoA_dh_1 PF00441.19 KOO30805.1 - 1.5e-32 112.7 1.5 2.9e-32 111.8 1.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.14 KOO30805.1 - 1.1e-13 50.4 0.4 3.7e-13 48.7 0.1 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 KOO30805.1 - 1.3e-11 44.9 4.2 1.3e-11 44.9 2.9 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 KOO30805.1 - 6.4e-09 36.3 0.9 1.2e-08 35.5 0.2 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain HpaB_N PF11794.3 KOO30805.1 - 0.048 13.0 0.0 0.081 12.2 0.0 1.3 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal LRR_6 PF13516.1 KOO30806.1 - 4.9e-12 44.5 11.3 0.2 11.8 0.3 6.6 5 2 1 6 6 6 5 Leucine Rich repeat LRR_8 PF13855.1 KOO30806.1 - 0.0028 17.3 0.7 3.2 7.5 0.1 3.6 4 1 0 4 4 4 2 Leucine rich repeat LRR_1 PF00560.28 KOO30806.1 - 0.11 12.5 1.4 1e+02 3.5 0.0 4.3 5 1 0 5 5 5 0 Leucine Rich Repeat Na_H_Exchanger PF00999.16 KOO30807.1 - 3.8e-66 223.1 50.3 5e-66 222.7 34.9 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TrkA_N PF02254.13 KOO30807.1 - 2.1e-10 40.6 0.1 4e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain 2-Hacid_dh_C PF02826.14 KOO30807.1 - 0.025 13.7 0.0 0.041 13.0 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Aminotran_1_2 PF00155.16 KOO30808.1 - 1.5e-18 66.9 0.0 2.6e-18 66.1 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class I and II WW PF00397.21 KOO30809.1 - 3.1e-09 36.5 0.1 5.9e-09 35.6 0.1 1.5 1 0 0 1 1 1 1 WW domain WD40 PF00400.27 KOO30810.1 - 1e-61 202.7 23.1 6.7e-11 41.6 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 KOO30810.1 - 0.0051 16.5 0.0 0.079 12.6 0.0 2.4 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 KOO30810.1 - 0.055 11.5 7.6 3.7 5.5 0.1 4.5 1 1 3 4 4 4 0 Nucleoporin Nup120/160 Na_Ca_ex PF01699.19 KOO30811.1 - 1.7e-36 124.9 33.4 1.5e-18 66.7 6.8 3.2 2 1 0 2 2 2 2 Sodium/calcium exchanger protein PH PF00169.24 KOO30811.1 - 0.23 11.6 0.1 0.46 10.7 0.1 1.5 1 0 0 1 1 1 0 PH domain HECT PF00632.20 KOO30812.1 - 7.9e-51 173.0 0.0 1.1e-50 172.5 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) UBA PF00627.26 KOO30812.1 - 1.1e-14 53.6 7.0 5.9e-07 29.1 0.3 4.5 5 0 0 5 5 5 2 UBA/TS-N domain UBA_4 PF14555.1 KOO30812.1 - 0.019 14.5 0.2 0.069 12.6 0.0 2.0 2 0 0 2 2 2 0 UBA-like domain zf-RING_5 PF14634.1 KOO30813.1 - 4.9e-06 26.1 5.2 8.2e-06 25.4 3.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 KOO30813.1 - 0.00064 19.3 5.4 0.0017 17.9 3.7 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO30813.1 - 0.0031 17.1 3.5 0.0049 16.5 2.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.1 KOO30813.1 - 0.0037 17.0 2.5 0.0061 16.3 1.7 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_2 PF13923.1 KOO30813.1 - 0.0037 17.2 7.5 0.0069 16.3 5.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) TerY-C PF15616.1 KOO30813.1 - 0.0063 16.4 2.1 0.0063 16.4 1.4 1.9 2 1 0 2 2 2 1 TerY-C metal binding domain DUF745 PF05335.8 KOO30813.1 - 0.045 13.2 3.4 0.065 12.7 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) zf-RING_2 PF13639.1 KOO30813.1 - 0.13 12.1 6.9 0.29 10.9 4.8 1.6 1 1 0 1 1 1 0 Ring finger domain zf-C3HC4_4 PF15227.1 KOO30813.1 - 0.17 11.7 4.1 0.45 10.4 2.8 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.3 KOO30813.1 - 0.2 11.2 2.7 0.43 10.1 1.8 1.6 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-MIZ PF02891.15 KOO30813.1 - 0.75 9.3 7.1 1.5 8.3 4.9 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-AN1 PF01428.11 KOO30813.1 - 1.6 8.6 6.3 0.4 10.5 0.8 2.2 1 1 1 2 2 2 0 AN1-like Zinc finger Mad3_BUB1_I PF08311.7 KOO30814.1 - 8.8e-10 38.4 0.0 6e-09 35.7 0.0 2.0 1 1 1 2 2 2 1 Mad3/BUB1 homology region 1 Aldo_ket_red PF00248.16 KOO30815.1 - 6.5e-60 202.3 0.0 7.8e-60 202.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Hexapep PF00132.19 KOO30817.1 - 0.013 15.0 0.1 0.41 10.2 0.0 2.4 2 0 0 2 2 2 0 Bacterial transferase hexapeptide (six repeats) DUF563 PF04577.9 KOO30820.1 - 2.2e-05 24.4 0.1 3.3e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF563) PDZ PF00595.19 KOO30821.1 - 0.013 15.6 0.1 0.027 14.6 0.1 1.5 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) Macro PF01661.16 KOO30822.1 - 4.1e-12 46.0 0.0 6.2e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 Macro domain DUF3273 PF11677.3 KOO30823.1 - 0.029 13.6 0.1 0.029 13.6 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3273) EF-hand_6 PF13405.1 KOO30825.1 - 4e-05 23.1 0.5 0.00015 21.4 0.4 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.27 KOO30825.1 - 0.0006 18.9 0.2 0.0012 17.9 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.1 KOO30825.1 - 0.0016 17.7 0.6 0.0035 16.5 0.4 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO30825.1 - 0.012 15.7 0.4 0.028 14.5 0.3 1.6 1 0 0 1 1 1 0 EF-hand domain pair UPF0197 PF05251.7 KOO30825.1 - 0.018 15.2 0.8 0.018 15.2 0.6 1.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0197) DUF766 PF05571.7 KOO30825.1 - 0.36 10.0 5.1 0.53 9.5 3.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF766) Metal_resist PF13801.1 KOO30827.1 - 0.01 15.8 3.2 0.01 15.8 2.2 2.2 2 2 0 2 2 2 0 Heavy-metal resistance HTH_28 PF13518.1 KOO30827.1 - 0.7 9.9 5.3 1 9.4 0.4 3.2 2 1 1 3 3 3 0 Helix-turn-helix domain XPG_I PF00867.13 KOO30828.1 - 1.3e-18 66.8 0.0 2.3e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 KOO30828.1 - 1.5e-15 57.2 0.0 2.8e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.2 KOO30828.1 - 1.9e-07 30.8 0.0 2.8e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 XPG domain containing HemY_N PF07219.8 KOO30828.1 - 0.064 12.8 0.1 0.17 11.4 0.0 1.7 1 0 0 1 1 1 0 HemY protein N-terminus JmjC PF02373.17 KOO30829.1 - 6.2e-13 48.9 0.0 1.5e-12 47.7 0.0 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase Chromo PF00385.19 KOO30829.1 - 3.2e-07 29.9 2.3 7.2e-07 28.7 1.6 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain NAD_binding_1 PF00175.16 KOO30830.1 - 4.5e-16 59.3 0.1 6.9e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 KOO30830.1 - 0.0063 16.6 0.0 0.0093 16.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 KOO30830.1 - 0.024 14.5 0.2 0.5 10.2 0.0 2.2 2 0 0 2 2 2 0 Ferric reductase NAD binding domain Pkinase PF00069.20 KOO30831.1 - 6.8e-30 104.0 0.0 1.2e-29 103.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO30831.1 - 3.6e-25 88.5 0.0 6.1e-25 87.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase SAP PF02037.22 KOO30832.1 - 2.8e-07 29.8 0.0 5.9e-07 28.8 0.0 1.6 1 0 0 1 1 1 1 SAP domain Chromo PF00385.19 KOO30832.1 - 5.2e-07 29.2 2.0 1.1e-06 28.2 1.4 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain EF-hand_1 PF00036.27 KOO30835.1 - 1.4e-05 24.0 0.1 2.8e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO30835.1 - 7e-05 22.3 0.1 0.00016 21.3 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.1 KOO30835.1 - 0.0029 16.8 0.1 0.0061 15.8 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO30835.1 - 0.0033 17.5 0.0 0.0063 16.6 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO30835.1 - 0.1 12.1 0.1 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair DUF4199 PF13858.1 KOO30835.1 - 0.28 11.0 4.1 2.8 7.8 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) AAA_28 PF13521.1 KOO30836.1 - 3e-17 63.0 0.0 1.8e-16 60.5 0.0 2.3 1 1 0 1 1 1 1 AAA domain ArgK PF03308.11 KOO30836.1 - 0.0038 16.0 0.1 0.0085 14.8 0.0 1.6 1 0 0 1 1 1 1 ArgK protein KTI12 PF08433.5 KOO30836.1 - 0.025 13.7 0.0 0.046 12.9 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 IQ PF00612.22 KOO30836.1 - 0.14 11.8 0.8 0.4 10.4 0.6 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif SET PF00856.23 KOO30837.1 - 0.00013 22.3 0.1 0.0012 19.1 0.0 2.1 1 1 0 1 1 1 1 SET domain SAF PF08666.7 KOO30837.1 - 0.02 15.2 0.3 3.7 8.0 0.0 2.7 2 0 0 2 2 2 0 SAF domain SAF_2 PF13144.1 KOO30837.1 - 0.093 12.2 0.0 0.25 10.7 0.0 1.7 2 0 0 2 2 2 0 SAF-like Sel1 PF08238.7 KOO30840.1 - 5.5e-13 49.0 14.5 2.4e-06 27.9 0.9 4.0 4 0 0 4 4 4 3 Sel1 repeat U-box PF04564.10 KOO30840.1 - 1e-12 47.8 0.0 1.9e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO30840.1 - 0.0047 16.4 0.0 0.0095 15.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit UPF0515 PF15135.1 KOO30841.1 - 0.02 13.9 0.5 0.034 13.2 0.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein UPF0515 Ycf15 PF10705.4 KOO30841.1 - 0.12 12.4 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Chloroplast protein precursor Ycf15 putative Pkinase PF00069.20 KOO30842.1 - 1.7e-65 220.7 0.0 2.4e-65 220.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO30842.1 - 5.7e-44 150.1 0.0 8.6e-44 149.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO30842.1 - 0.0016 17.4 0.0 0.0027 16.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like His_Phos_1 PF00300.17 KOO30843.1 - 3.8e-16 59.5 0.0 6.3e-16 58.8 0.0 1.4 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Abhydrolase_6 PF12697.2 KOO30843.1 - 0.028 14.2 0.1 0.029 14.2 0.1 1.3 1 1 0 1 1 1 0 Alpha/beta hydrolase family Pkinase PF00069.20 KOO30844.1 - 4.2e-47 160.4 0.0 9.6e-47 159.3 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO30844.1 - 3.3e-28 98.4 0.1 1.6e-24 86.3 0.0 3.0 2 1 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 KOO30844.1 - 0.0002 21.2 0.1 0.0002 21.2 0.1 2.4 2 2 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO30844.1 - 0.0017 17.4 0.0 0.0055 15.7 0.0 1.8 1 1 0 1 1 1 1 Kinase-like YukC PF10140.4 KOO30844.1 - 0.0046 15.5 0.0 0.0066 15.0 0.0 1.1 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC RIO1 PF01163.17 KOO30844.1 - 0.037 13.3 0.0 0.11 11.8 0.0 1.7 1 0 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.4 KOO30844.1 - 0.046 13.0 0.0 0.073 12.3 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pox_ser-thr_kin PF05445.6 KOO30844.1 - 0.27 9.9 0.0 0.39 9.4 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase EF-hand_6 PF13405.1 KOO30845.1 - 1.5e-12 46.2 5.8 0.0011 18.6 0.1 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.27 KOO30845.1 - 3.4e-12 44.7 7.8 0.00091 18.3 0.4 4.4 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.1 KOO30845.1 - 6.7e-10 38.9 2.0 0.013 15.6 0.0 3.8 3 2 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO30845.1 - 2.2e-09 36.7 5.7 0.0008 18.9 0.7 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO30845.1 - 3e-07 29.4 5.8 0.11 11.8 0.1 4.4 4 0 0 4 4 4 3 EF hand Leucyl-specific PF14795.1 KOO30845.1 - 1.4 8.8 4.0 2.1 8.2 0.9 2.8 2 1 0 2 2 2 0 Leucine-tRNA synthetase-specific domain DUF972 PF06156.8 KOO30845.1 - 5.3 7.4 14.7 14 6.0 6.8 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF972) PALP PF00291.20 KOO30846.1 - 5.5e-55 186.7 0.0 7.5e-55 186.3 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Glutaredoxin PF00462.19 KOO30846.1 - 2.6e-11 43.3 0.0 5.5e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin CMD PF02627.15 KOO30847.1 - 0.0018 18.0 0.0 0.0052 16.5 0.0 1.9 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family Thioredoxin_2 PF13098.1 KOO30847.1 - 0.029 14.5 0.0 0.053 13.7 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain N6-adenineMlase PF10237.4 KOO30848.1 - 6.2e-20 71.4 0.0 1.6e-19 70.1 0.0 1.7 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase PDZ_2 PF13180.1 KOO30848.1 - 6.9e-11 41.8 0.4 0.048 13.5 0.0 3.7 3 0 0 3 3 3 3 PDZ domain PDZ PF00595.19 KOO30848.1 - 1.2e-09 38.1 2.7 0.044 13.9 0.1 3.9 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) EF-hand_7 PF13499.1 KOO30848.1 - 5.7e-05 23.1 5.6 0.00016 21.7 3.9 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO30848.1 - 0.00023 20.2 4.3 0.0085 15.3 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO30848.1 - 0.0044 16.3 0.5 0.0044 16.3 0.4 2.4 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO30848.1 - 0.017 14.9 2.3 0.26 11.2 0.1 2.6 2 0 0 2 2 2 0 EF-hand domain EF-hand_8 PF13833.1 KOO30848.1 - 0.019 14.5 5.8 0.04 13.5 2.9 2.3 1 1 1 2 2 2 0 EF-hand domain pair Glyco_hydro_79n PF03662.9 KOO30849.1 - 3.7e-22 78.3 0.0 3.4e-13 48.9 0.0 2.2 2 0 0 2 2 2 2 Glycosyl hydrolase family 79, N-terminal domain BAF PF02961.9 KOO30850.1 - 2.2e-12 47.1 0.0 9.2e-06 25.8 0.0 3.5 4 0 0 4 4 4 2 Barrier to autointegration factor HHH_5 PF14520.1 KOO30850.1 - 4.6e-05 23.5 0.2 2.3 8.4 0.0 3.6 4 0 0 4 4 4 2 Helix-hairpin-helix domain Patatin PF01734.17 KOO30853.1 - 0.048 13.5 0.0 0.062 13.2 0.0 1.2 1 0 0 1 1 1 0 Patatin-like phospholipase DUF4253 PF14062.1 KOO30854.1 - 0.13 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4253) YjgP_YjgQ PF03739.9 KOO30855.1 - 2.6 6.6 6.1 4.6 5.8 4.2 1.3 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family Glyco_trans_2_3 PF13632.1 KOO30855.1 - 6.5 6.4 7.2 25 4.5 0.0 2.8 3 0 0 3 3 3 0 Glycosyl transferase family group 2 TFIIE-A_C-term PF11521.3 KOO30856.1 - 4.5e-06 26.5 0.5 4.5e-06 26.5 0.4 1.9 2 0 0 2 2 2 1 C-terminal general transcription factor TFIIE alpha TFIIE_alpha PF02002.12 KOO30856.1 - 0.0013 18.1 0.1 0.0041 16.6 0.0 1.8 2 0 0 2 2 2 1 TFIIE alpha subunit FGase PF05013.7 KOO30856.1 - 0.011 15.6 0.4 0.067 13.0 0.1 2.1 1 1 1 2 2 2 0 N-formylglutamate amidohydrolase MarR_2 PF12802.2 KOO30856.1 - 0.028 14.0 0.3 0.089 12.4 0.2 1.9 1 1 0 1 1 1 0 MarR family Methyltransf_13 PF08421.6 KOO30856.1 - 0.12 11.8 0.1 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 Putative zinc binding domain DUF2250 PF10007.4 KOO30856.1 - 0.28 11.1 1.1 0.56 10.1 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) DUF4139 PF13598.1 KOO30856.1 - 1.7 7.8 8.8 0.42 9.8 3.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4139) HATPase_c PF02518.21 KOO30857.1 - 1.3e-16 60.2 0.3 3.9e-16 58.7 0.2 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 KOO30857.1 - 1.4e-14 54.0 0.0 3.1e-14 52.9 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain Hpt PF01627.18 KOO30857.1 - 5.1e-07 29.6 0.2 1.5e-06 28.1 0.1 1.8 1 0 0 1 1 1 1 Hpt domain HATPase_c_3 PF13589.1 KOO30857.1 - 0.0064 16.1 0.1 0.018 14.6 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase rve PF00665.21 KOO30859.1 - 5e-09 36.2 0.1 9.2e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain ADPrib_exo_Tox PF03496.9 KOO30860.1 - 3.3e-08 32.9 0.0 8.4e-08 31.6 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme ART PF01129.13 KOO30860.1 - 1.8e-07 30.5 1.8 1.8e-06 27.2 0.0 2.9 3 0 0 3 3 3 1 NAD:arginine ADP-ribosyltransferase Ycf1 PF05758.7 KOO30860.1 - 0.28 8.8 2.8 0.39 8.3 1.9 1.1 1 0 0 1 1 1 0 Ycf1 FAST_1 PF06743.10 KOO30861.1 - 1.6e-07 30.9 0.0 0.33 10.6 0.0 4.7 4 1 1 5 5 5 3 FAST kinase-like protein, subdomain 1 Vps55 PF04133.9 KOO30862.1 - 1.1e-15 57.3 8.5 1.3e-15 57.2 5.9 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 Hanta_G2 PF01561.11 KOO30862.1 - 0.37 9.1 2.6 0.53 8.6 1.8 1.2 1 0 0 1 1 1 0 Hantavirus glycoprotein G2 DUF3397 PF11877.3 KOO30862.1 - 3.7 7.5 10.8 0.13 12.2 2.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3397) RseC_MucC PF04246.7 KOO30862.1 - 8 6.0 6.4 19 4.8 0.9 2.1 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC EF-hand_7 PF13499.1 KOO30863.1 - 4.2e-18 65.2 0.2 2.5e-08 33.9 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO30863.1 - 5.5e-15 53.8 2.2 0.00059 19.4 0.0 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.27 KOO30863.1 - 1.7e-14 51.9 0.2 0.00033 19.7 0.0 4.4 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.1 KOO30863.1 - 6.6e-13 47.3 1.3 0.00042 19.5 0.0 4.4 4 0 0 4 4 4 2 EF hand GPS PF01825.16 KOO30863.1 - 2.7e-11 43.3 4.1 5.4e-11 42.4 2.9 1.5 1 0 0 1 1 1 1 Latrophilin/CL-1-like GPS domain EF-hand_8 PF13833.1 KOO30863.1 - 1.6e-05 24.3 0.5 0.053 13.1 0.0 3.9 2 2 2 4 4 4 2 EF-hand domain pair Josephin PF02099.12 KOO30863.1 - 0.018 14.6 0.0 4.2 6.9 0.0 2.6 1 1 1 2 2 2 0 Josephin EF-hand_9 PF14658.1 KOO30863.1 - 0.075 12.9 0.0 9 6.2 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain LRR_6 PF13516.1 KOO30865.1 - 2.2e-16 58.0 0.5 0.078 13.0 0.0 7.5 7 0 0 7 7 7 4 Leucine Rich repeat LRR_1 PF00560.28 KOO30865.1 - 2.7e-06 26.6 0.3 11 6.4 0.0 5.4 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_4 PF12799.2 KOO30865.1 - 0.0014 18.2 0.2 55 3.5 0.2 4.8 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) Ecm33 PF12454.3 KOO30865.1 - 0.011 15.5 3.8 0.24 11.3 0.0 3.9 4 0 0 4 4 4 0 GPI-anchored cell wall organization protein LRR_7 PF13504.1 KOO30865.1 - 0.022 14.8 2.6 30 5.4 0.0 5.0 5 0 0 5 5 5 0 Leucine rich repeat Branch PF02485.16 KOO30866.1 - 1.8e-21 76.4 0.1 8.5e-14 51.3 0.0 2.1 1 1 1 2 2 2 2 Core-2/I-Branching enzyme NolV PF06635.7 KOO30866.1 - 0.019 14.1 0.0 0.046 12.8 0.0 1.6 1 0 0 1 1 1 0 Nodulation protein NolV HTH_1 PF00126.22 KOO30867.1 - 0.027 14.1 0.0 0.051 13.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family WWE PF02825.15 KOO30867.1 - 0.058 12.8 0.1 0.78 9.2 0.0 2.7 2 1 0 2 2 2 0 WWE domain Lipase_GDSL PF00657.17 KOO30868.1 - 4.9e-28 98.5 0.0 6e-28 98.2 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.1 KOO30868.1 - 6.1e-28 98.1 0.8 1.7e-27 96.6 0.1 1.8 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family WWE PF02825.15 KOO30869.1 - 9.1e-14 50.6 0.1 1.6e-13 49.8 0.1 1.3 1 0 0 1 1 1 1 WWE domain rve PF00665.21 KOO30871.1 - 0.00091 19.3 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain zf-DHHC PF01529.15 KOO30873.1 - 4.8e-15 55.3 16.8 2.5e-14 53.0 7.1 2.4 2 1 0 2 2 2 2 DHHC palmitoyltransferase Thiolase_N PF00108.18 KOO30877.1 - 1.5e-56 191.3 6.4 2.6e-56 190.5 4.4 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 KOO30877.1 - 1.2e-42 144.1 0.4 1.2e-42 144.1 0.3 2.3 2 1 1 3 3 3 1 Thiolase, C-terminal domain Wbp11 PF09429.5 KOO30878.1 - 0.042 13.8 2.6 3.2 7.7 0.0 2.5 1 1 1 2 2 2 0 WW domain binding protein 11 CCDC144C PF14915.1 KOO30878.1 - 0.09 11.6 11.0 0.027 13.4 5.7 1.6 2 1 0 2 2 2 0 CCDC144C protein coiled-coil region FliE PF02049.13 KOO30878.1 - 0.14 12.1 7.2 0.096 12.7 2.6 2.1 2 0 0 2 2 2 0 Flagellar hook-basal body complex protein FliE ERM PF00769.14 KOO30878.1 - 0.81 9.1 15.6 0.93 8.9 10.8 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family APG6 PF04111.7 KOO30878.1 - 0.93 8.4 5.6 1.1 8.2 3.9 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 FUSC PF04632.7 KOO30878.1 - 1.4 7.2 14.8 1.6 7.0 10.3 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family TMF_DNA_bd PF12329.3 KOO30878.1 - 1.9 8.3 10.1 1.5 8.6 1.0 2.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Spc24 PF08286.6 KOO30878.1 - 3.4 7.4 5.5 15 5.2 0.2 2.5 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF4404 PF14357.1 KOO30878.1 - 5.7 7.4 7.0 14 6.2 3.3 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) Kinesin PF00225.18 KOO30879.1 - 1.5e-52 178.4 0.1 1.6e-25 89.4 0.4 2.1 1 1 1 2 2 2 2 Kinesin motor domain HEXIM PF15313.1 KOO30880.1 - 4.9 7.3 10.5 0.18 11.9 0.1 2.6 2 2 0 2 2 2 0 Hexamethylene bis-acetamide-inducible protein TnpV PF14198.1 KOO30880.1 - 5 7.0 7.9 1.2 9.0 0.1 2.6 3 0 0 3 3 3 0 Transposon-encoded protein TnpV GAS PF13851.1 KOO30881.1 - 0.11 11.6 15.5 0.63 9.2 2.0 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Reo_sigmaC PF04582.7 KOO30881.1 - 0.98 8.5 5.7 0.25 10.5 1.1 1.9 2 0 0 2 2 2 0 Reovirus sigma C capsid protein IFT57 PF10498.4 KOO30881.1 - 1.4 7.6 12.2 0.023 13.4 2.8 1.8 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Lectin_N PF03954.9 KOO30881.1 - 1.5 8.1 6.3 0.12 11.7 0.6 1.9 2 1 0 2 2 2 0 Hepatic lectin, N-terminal domain ERM PF00769.14 KOO30881.1 - 1.6 8.1 25.5 0.45 10.0 3.9 2.3 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Myosin_tail_1 PF01576.14 KOO30881.1 - 1.8 6.2 29.3 0.59 7.7 7.2 2.0 2 0 0 2 2 2 0 Myosin tail IncA PF04156.9 KOO30881.1 - 2.5 7.6 25.0 0.014 15.0 4.1 2.3 2 0 0 2 2 2 0 IncA protein PFK PF00365.15 KOO30883.1 - 2.3e-32 112.1 3.4 3.3e-32 111.5 2.0 1.5 1 1 1 2 2 2 1 Phosphofructokinase NAD_kinase PF01513.16 KOO30883.1 - 0.0071 15.1 0.1 0.013 14.2 0.1 1.4 1 0 0 1 1 1 1 ATP-NAD kinase Sulphotransf PF09037.5 KOO30883.1 - 0.22 10.9 0.0 0.39 10.1 0.0 1.3 1 0 0 1 1 1 0 Stf0 sulphotransferase Choline_transpo PF04515.7 KOO30884.1 - 3.5e-46 157.5 29.4 3.5e-46 157.5 20.4 2.2 2 0 0 2 2 2 2 Plasma-membrane choline transporter Thioredoxin PF00085.15 KOO30885.1 - 3.4e-15 55.6 0.1 7.3e-15 54.5 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin EF-hand_6 PF13405.1 KOO30885.1 - 4.4e-12 44.7 0.3 0.00043 19.9 0.0 3.7 4 0 0 4 4 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO30885.1 - 6.7e-09 35.7 0.0 0.0049 16.9 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO30885.1 - 7.7e-08 31.0 0.0 0.014 14.6 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO30885.1 - 1.2e-07 30.7 0.3 0.011 15.0 0.0 2.7 2 0 0 2 2 2 2 EF hand Thioredoxin_8 PF13905.1 KOO30885.1 - 1.2e-05 25.3 0.1 2.2e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like EF-hand_8 PF13833.1 KOO30885.1 - 0.00038 20.0 0.4 0.68 9.6 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair Thioredoxin_2 PF13098.1 KOO30885.1 - 0.0088 16.2 0.1 0.02 15.0 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.16 KOO30885.1 - 0.012 15.2 0.1 0.025 14.2 0.1 1.4 1 0 0 1 1 1 0 AhpC/TSA family Redoxin PF08534.5 KOO30885.1 - 0.013 15.0 0.1 0.026 14.0 0.1 1.4 1 0 0 1 1 1 0 Redoxin Thioredoxin_7 PF13899.1 KOO30885.1 - 0.015 15.3 0.2 0.037 14.0 0.1 1.6 1 0 0 1 1 1 0 Thioredoxin-like EF-hand_7 PF13499.1 KOO30886.1 - 5.5e-44 148.1 14.6 1.9e-15 56.7 1.0 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO30886.1 - 1.2e-39 130.5 26.3 2.2e-07 29.6 0.3 6.3 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.1 KOO30886.1 - 1.2e-37 124.3 24.9 7.7e-07 28.4 0.4 6.3 6 0 0 6 6 6 6 EF-hand domain EF-hand_5 PF13202.1 KOO30886.1 - 2.1e-37 124.8 31.1 6.1e-08 31.6 0.2 6.3 6 0 0 6 6 6 6 EF hand EF-hand_8 PF13833.1 KOO30886.1 - 1.2e-19 69.5 32.4 1.8e-05 24.2 0.3 6.3 3 3 3 6 6 6 6 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO30886.1 - 1.9e-07 31.0 4.9 0.21 11.6 0.1 4.9 1 1 3 4 4 4 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOO30886.1 - 2.3e-05 24.1 0.0 0.32 10.9 0.0 4.4 4 1 1 5 5 5 1 EF-hand domain EF-hand_4 PF12763.2 KOO30886.1 - 4.5e-05 23.1 4.7 2.3 8.0 0.0 4.2 2 1 2 4 4 4 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.8 KOO30886.1 - 0.00036 20.1 3.6 9 5.8 0.0 5.2 4 2 2 6 6 6 1 Caleosin related protein OST-HTH PF12872.2 KOO30886.1 - 0.013 15.2 1.2 17 5.3 0.1 4.4 5 0 0 5 5 5 0 OST-HTH/LOTUS domain ART PF01129.13 KOO30886.1 - 0.023 13.8 8.0 1.7 7.6 0.1 3.0 3 0 0 3 3 3 0 NAD:arginine ADP-ribosyltransferase TM1586_NiRdase PF14512.1 KOO30886.1 - 0.058 12.5 0.4 5 6.2 0.0 2.8 3 0 0 3 3 3 0 Putative TM nitroreductase DUF2780 PF11075.3 KOO30886.1 - 0.38 10.7 1.8 45 4.0 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function VcgC/VcgE (DUF2780) Barwin PF00967.12 KOO30886.1 - 0.66 9.6 8.8 15 5.3 0.1 4.5 3 3 2 6 6 6 0 Barwin family VCBS PF13517.1 KOO30886.1 - 2.3 8.6 12.5 1.1 9.7 0.5 4.6 5 1 0 5 5 5 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Glyco_hydro_31 PF01055.21 KOO30887.1 - 5.2e-148 493.5 5.5 6.7e-148 493.1 3.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 KOO30887.1 - 1.2e-17 63.4 0.1 3.2e-17 62.1 0.1 1.8 1 0 0 1 1 1 1 Galactose mutarotase-like LRR_5 PF13306.1 KOO30888.1 - 3.1e-61 204.7 0.2 2.3e-40 137.2 0.0 2.2 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO30888.1 - 2.6e-09 36.6 0.0 0.0013 18.4 0.0 3.3 1 1 1 3 3 3 2 Leucine rich repeat LETM1 PF07766.8 KOO30889.1 - 2e-68 230.3 8.8 4.3e-40 137.4 1.3 2.5 1 1 1 2 2 2 2 LETM1-like protein EF-hand_7 PF13499.1 KOO30889.1 - 3.2e-10 39.9 0.2 2.6e-08 33.8 0.0 3.2 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO30889.1 - 1.5e-09 36.4 1.3 0.00064 18.8 0.1 3.1 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO30889.1 - 2.8e-09 35.8 0.5 0.0014 17.9 0.0 3.0 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO30889.1 - 2.6e-08 33.0 0.3 0.001 18.7 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO30889.1 - 3.8e-06 26.4 0.3 0.052 13.1 0.1 3.2 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO30889.1 - 0.00013 21.9 1.3 0.00058 19.8 0.0 2.6 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region PG_binding_1 PF01471.13 KOO30889.1 - 0.013 15.4 0.0 0.035 14.0 0.0 1.8 1 0 0 1 1 1 0 Putative peptidoglycan binding domain HEAT_2 PF13646.1 KOO30890.1 - 2.3e-07 30.9 0.0 0.00043 20.4 0.0 4.2 3 2 1 4 4 4 3 HEAT repeats HEAT PF02985.17 KOO30890.1 - 3.6e-07 29.7 1.7 0.023 14.7 0.0 4.9 5 0 0 5 5 5 2 HEAT repeat DUF4042 PF13251.1 KOO30890.1 - 0.03 13.7 0.0 0.66 9.4 0.0 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4042) HEAT_PBS PF03130.11 KOO30890.1 - 0.33 11.5 4.3 5.1 7.8 0.2 3.6 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat HEAT PF02985.17 KOO30891.1 - 7e-09 35.0 9.7 0.17 12.0 0.0 5.9 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.1 KOO30891.1 - 2.4e-07 30.9 2.3 0.0062 16.7 0.4 3.8 3 1 0 4 4 4 2 HEAT repeats HEAT_EZ PF13513.1 KOO30891.1 - 0.085 13.3 10.0 9.2 6.8 0.0 5.1 4 1 1 5 5 5 0 HEAT-like repeat 2OG-FeII_Oxy_3 PF13640.1 KOO30892.1 - 0.00025 21.4 0.1 0.00062 20.2 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO30892.1 - 0.011 15.9 0.0 0.06 13.6 0.0 2.0 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily PfkB PF00294.19 KOO30893.1 - 1.2e-24 87.0 0.1 1.4e-24 86.7 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Glyco_transf_34 PF05637.7 KOO30894.1 - 0.00042 19.8 1.7 0.65 9.4 0.1 2.5 2 0 0 2 2 2 2 galactosyl transferase GMA12/MNN10 family DUF2237 PF09996.4 KOO30895.1 - 2.7e-09 36.5 6.3 5.1e-09 35.6 4.3 1.4 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2237) GST_N_3 PF13417.1 KOO30896.1 - 1.7e-08 34.5 0.0 2.7e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KOO30896.1 - 4.3e-07 29.7 1.4 8.4e-07 28.7 0.9 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 KOO30896.1 - 3.6e-05 23.6 0.0 6.1e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 KOO30896.1 - 5.1e-05 23.1 0.0 9.3e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 KOO30896.1 - 5.7e-05 23.5 0.1 9.2e-05 22.8 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 KOO30896.1 - 0.00038 20.5 0.0 0.00084 19.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain RRM_1 PF00076.17 KOO30897.1 - 2.2e-15 56.0 0.0 3.3e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO30897.1 - 4.1e-11 42.6 0.0 6.6e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO30897.1 - 5.5e-09 35.7 0.1 8.7e-09 35.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3791 PF12668.2 KOO30897.1 - 0.067 12.8 0.0 0.84 9.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3791) Antitoxin-MazE PF04014.13 KOO30897.1 - 0.1 12.3 0.3 13 5.6 0.0 2.3 2 0 0 2 2 2 0 Antidote-toxin recognition MazE L51_S25_CI-B8 PF05047.11 KOO30900.1 - 5.4e-09 35.6 0.0 6.6e-09 35.3 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain DNA_primase_S PF01896.14 KOO30901.1 - 2.1e-46 157.3 0.0 3.1e-46 156.7 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase small subunit Histone PF00125.19 KOO30902.1 - 2.1e-29 101.4 0.5 2.6e-29 101.1 0.4 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 KOO30902.1 - 0.0012 18.9 0.1 0.0016 18.5 0.1 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CENP-T PF15511.1 KOO30902.1 - 0.011 14.9 0.0 0.013 14.7 0.0 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T CBFD_NFYB_HMF PF00808.18 KOO30902.1 - 0.011 15.7 0.7 0.019 14.9 0.5 1.4 1 1 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.10 KOO30902.1 - 0.016 14.9 0.0 0.02 14.6 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit TAF PF02969.12 KOO30902.1 - 0.035 14.0 0.2 0.063 13.2 0.2 1.4 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) Bromo_TP PF07524.8 KOO30902.1 - 0.098 12.4 0.1 0.19 11.4 0.1 1.4 1 1 0 1 1 1 0 Bromodomain associated XPG_I PF00867.13 KOO30904.1 - 6.4e-22 77.4 0.0 1.6e-21 76.1 0.0 1.7 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 KOO30904.1 - 1.1e-20 73.8 0.0 1.7e-20 73.1 0.0 1.4 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.2 KOO30904.1 - 4e-08 33.0 0.5 7.2e-08 32.2 0.1 1.5 1 1 0 1 1 1 1 XPG domain containing 5_3_exonuc_N PF02739.11 KOO30904.1 - 0.018 14.3 0.0 2.6 7.3 0.1 2.4 2 0 0 2 2 2 0 5'-3' exonuclease, N-terminal resolvase-like domain 5_3_exonuc PF01367.15 KOO30904.1 - 0.023 14.9 0.0 0.067 13.4 0.0 1.8 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold Transposase_20 PF02371.11 KOO30904.1 - 0.033 14.2 0.0 0.11 12.5 0.0 2.0 1 0 0 1 1 1 0 Transposase IS116/IS110/IS902 family HEAT PF02985.17 KOO30905.1 - 4.7e-13 48.0 29.5 0.27 11.4 0.0 11.6 11 0 0 11 11 11 5 HEAT repeat HEAT_2 PF13646.1 KOO30905.1 - 0.0012 19.0 10.4 0.0026 17.9 1.0 12.5 9 4 3 12 12 12 6 HEAT repeats Adaptin_N PF01602.15 KOO30905.1 - 0.026 12.8 0.1 0.42 8.8 0.0 2.3 2 0 0 2 2 2 0 Adaptin N terminal region Proteasom_PSMB PF10508.4 KOO30905.1 - 0.28 9.4 0.1 0.64 8.2 0.0 1.5 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit IMS PF00817.15 KOO30906.1 - 8.9e-19 67.7 0.0 1.2e-18 67.2 0.0 1.2 1 0 0 1 1 1 1 impB/mucB/samB family Ribosomal_L30_N PF08079.7 KOO30907.1 - 3.4e-22 78.2 14.6 5.1e-22 77.6 10.2 1.3 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.15 KOO30907.1 - 3.2e-14 52.2 1.0 5.8e-14 51.4 0.3 1.7 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e DUF908 PF06012.7 KOO30907.1 - 0.00079 18.8 0.2 0.0011 18.3 0.1 1.2 1 0 0 1 1 1 1 Domain of Unknown Function (DUF908) adh_short PF00106.20 KOO30908.1 - 7.5e-18 65.0 5.0 7.5e-18 65.0 3.4 2.6 3 0 0 3 3 3 1 short chain dehydrogenase KR PF08659.5 KOO30908.1 - 5.9e-06 26.0 2.2 1.4e-05 24.8 1.5 1.6 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 KOO30908.1 - 8.9e-05 22.3 0.0 0.00017 21.4 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 KOO30908.1 - 0.0073 15.7 0.0 0.014 14.8 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.3 KOO30908.1 - 0.076 12.8 1.0 0.45 10.3 0.7 2.4 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase PsbQ PF05757.6 KOO30908.1 - 2.1 7.7 7.5 3.8 6.8 4.8 1.8 2 1 0 2 2 2 0 Oxygen evolving enhancer protein 3 (PsbQ) RNA_pol_L_2 PF13656.1 KOO30909.1 - 1.2e-26 91.9 0.0 1.5e-26 91.6 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 KOO30909.1 - 1.6e-07 30.3 0.0 2.1e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain SbmA_BacA PF05992.7 KOO30910.1 - 4.9e-32 111.3 0.0 5.4e-32 111.2 0.0 1.0 1 0 0 1 1 1 1 SbmA/BacA-like family ABC_membrane_2 PF06472.10 KOO30910.1 - 7.3e-08 31.8 0.0 1.2e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 Ecotin PF03974.8 KOO30912.1 - 6.8e-36 122.8 0.0 1.1e-35 122.1 0.0 1.3 1 0 0 1 1 1 1 Ecotin GFO_IDH_MocA PF01408.17 KOO30912.1 - 5.9e-14 52.6 0.2 1.3e-13 51.5 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DHC_N1 PF08385.7 KOO30915.1 - 8.1e-148 493.3 12.0 8.1e-148 493.3 8.3 2.8 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.8 KOO30915.1 - 4e-119 397.7 1.5 4e-119 397.7 1.0 3.2 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 KOO30915.1 - 5.7e-89 297.6 0.3 1.4e-88 296.2 0.1 1.8 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_7 PF12775.2 KOO30915.1 - 9.9e-34 116.6 0.3 6.2e-32 110.7 0.1 3.2 2 1 0 2 2 2 1 P-loop containing dynein motor region D3 AAA_8 PF12780.2 KOO30915.1 - 1.2e-16 60.4 0.0 2.8e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_5 PF07728.9 KOO30915.1 - 2.7e-10 40.1 4.8 0.02 14.5 0.0 5.8 4 2 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA PF00004.24 KOO30915.1 - 1.7e-05 25.0 4.4 0.66 10.1 0.0 4.2 4 0 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO30915.1 - 8e-05 22.7 9.8 0.039 13.9 0.0 5.1 4 1 0 4 4 4 2 AAA ATPase domain AAA_19 PF13245.1 KOO30915.1 - 0.0024 17.5 9.1 0.26 11.0 0.0 4.5 4 0 0 4 4 4 1 Part of AAA domain AAA_29 PF13555.1 KOO30915.1 - 0.035 13.6 0.1 5.1 6.6 0.0 2.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_22 PF13401.1 KOO30915.1 - 0.045 13.9 12.3 0.18 11.9 0.0 5.5 6 0 0 6 6 5 0 AAA domain AAA_33 PF13671.1 KOO30915.1 - 0.15 11.9 5.4 0.35 10.7 0.0 3.8 3 1 0 3 3 3 0 AAA domain EF-hand_1 PF00036.27 KOO30917.1 - 1.2e-35 118.1 13.8 5.7e-10 37.7 1.5 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO30917.1 - 2.5e-30 104.4 8.3 2.8e-15 56.2 1.8 2.4 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO30917.1 - 7.4e-30 100.1 10.0 1.6e-07 30.6 0.0 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 KOO30917.1 - 4.3e-27 93.4 12.8 1.9e-11 43.3 1.0 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO30917.1 - 6.6e-27 91.6 10.9 1.6e-07 30.3 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.1 KOO30917.1 - 4.8e-12 45.6 0.2 1.3e-05 24.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO30917.1 - 1.6e-06 28.1 0.2 0.023 14.7 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO30917.1 - 0.00018 21.1 1.2 0.16 11.7 0.1 2.4 1 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand UPF0154 PF03672.8 KOO30917.1 - 0.071 12.7 0.0 3.1 7.4 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) DUF1007 PF06226.8 KOO30917.1 - 0.11 12.2 0.7 5.7 6.6 0.0 3.2 3 1 1 4 4 4 0 Protein of unknown function (DUF1007) PRK PF00485.13 KOO30918.1 - 9e-19 67.7 0.0 5.9e-18 65.1 0.0 1.9 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_22 PF13401.1 KOO30918.1 - 0.00034 20.7 0.0 0.0011 19.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO30918.1 - 0.0012 19.6 0.0 0.0036 18.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain MobB PF03205.9 KOO30918.1 - 0.022 14.4 0.1 0.049 13.3 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B T2SE PF00437.15 KOO30918.1 - 0.024 13.5 0.1 0.043 12.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.1 KOO30918.1 - 0.043 14.1 0.0 0.08 13.2 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 KOO30918.1 - 0.055 13.4 0.3 0.23 11.3 0.0 2.1 3 0 0 3 3 3 0 AAA ATPase domain 6PF2K PF01591.13 KOO30918.1 - 0.092 11.8 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_25 PF13481.1 KOO30918.1 - 0.097 12.0 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.17 KOO30918.1 - 0.13 11.6 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain E2F_TDP PF02319.15 KOO30919.1 - 1.7e-23 81.9 0.0 3.1e-23 81.1 0.0 1.4 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.14 KOO30919.1 - 0.033 13.9 0.0 0.062 13.0 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB B3_4 PF03483.12 KOO30920.1 - 4.8e-21 74.9 0.0 9.2e-21 74.0 0.0 1.5 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.10 KOO30920.1 - 1.7e-11 43.7 0.0 6.9e-09 35.4 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetase B5 domain RVT_2 PF07727.9 KOO30922.1 - 9.3e-11 41.1 0.0 1.6e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_2 PF07727.9 KOO30924.1 - 1.7e-11 43.5 0.0 2.7e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EF-hand_6 PF13405.1 KOO30926.1 - 8.1e-18 62.6 3.2 0.0014 18.3 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.27 KOO30926.1 - 2.5e-17 60.7 4.8 0.00076 18.6 0.7 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO30926.1 - 2.3e-14 53.2 1.0 0.024 14.7 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO30926.1 - 6.3e-11 41.1 6.6 0.0014 17.8 0.1 4.9 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.1 KOO30926.1 - 6e-07 28.9 2.4 0.00022 20.7 0.1 4.0 3 1 1 4 4 4 1 EF-hand domain pair T2SF PF00482.18 KOO30926.1 - 0.54 10.1 5.8 0.096 12.6 0.2 2.6 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F DLIC PF05783.6 KOO30926.1 - 4.3 5.8 7.2 7.6 5.0 5.0 1.3 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Myb_DNA-binding PF00249.26 KOO30927.1 - 1.5e-08 34.5 0.1 3.8e-08 33.2 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain CUT PF02376.10 KOO30927.1 - 0.023 14.4 0.1 0.051 13.3 0.1 1.6 1 0 0 1 1 1 0 CUT domain DUF3792 PF12670.2 KOO30928.1 - 0.031 14.1 0.0 0.038 13.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3792) CS PF04969.11 KOO30929.1 - 9.9e-10 38.8 0.0 2.3e-09 37.6 0.0 1.7 1 1 0 1 1 1 1 CS domain VRR_NUC PF08774.6 KOO30929.1 - 0.0049 16.8 1.6 0.033 14.2 0.0 2.8 3 1 0 3 3 3 1 VRR-NUC domain Fibrillarin PF01269.12 KOO30930.1 - 4.1e-102 339.9 0.0 4.6e-102 339.7 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.5 KOO30930.1 - 5e-05 22.9 0.0 6.9e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.14 KOO30930.1 - 0.11 11.9 0.1 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) zf-DHHC PF01529.15 KOO30931.1 - 5.4e-22 78.0 1.3 7.3e-22 77.5 0.9 1.1 1 0 0 1 1 1 1 DHHC palmitoyltransferase AAA PF00004.24 KOO30932.1 - 5.1e-36 123.7 0.0 7.8e-36 123.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) CDC37_C PF08564.5 KOO30932.1 - 2.8e-10 39.9 0.0 7.6e-10 38.5 0.0 1.7 1 0 0 1 1 1 1 Cdc37 C terminal domain AAA_5 PF07728.9 KOO30932.1 - 9.9e-05 22.0 0.1 0.0008 19.1 0.1 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 KOO30932.1 - 0.00072 19.2 0.0 0.0027 17.4 0.0 2.0 1 0 0 1 1 1 1 Part of AAA domain TIP49 PF06068.8 KOO30932.1 - 0.00098 17.9 0.0 0.0015 17.2 0.0 1.2 1 0 0 1 1 1 1 TIP49 C-terminus AAA_16 PF13191.1 KOO30932.1 - 0.0022 17.9 0.0 0.0054 16.7 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.9 KOO30932.1 - 0.0023 17.8 0.0 0.0039 17.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 KOO30932.1 - 0.0024 17.9 0.0 0.011 15.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain Vps4_C PF09336.5 KOO30932.1 - 0.0035 17.1 0.0 0.0077 16.0 0.0 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_33 PF13671.1 KOO30932.1 - 0.0048 16.7 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO30932.1 - 0.0082 16.9 0.0 0.021 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 KOO30932.1 - 0.0089 15.4 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 KOO30932.1 - 0.01 15.7 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 KOO30932.1 - 0.011 14.8 0.0 0.022 13.9 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.1 KOO30932.1 - 0.012 15.2 0.0 0.022 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.7 KOO30932.1 - 0.017 14.1 0.0 0.029 13.3 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_18 PF13238.1 KOO30932.1 - 0.025 14.8 0.3 0.06 13.6 0.0 1.7 2 0 0 2 2 1 0 AAA domain DUF1080 PF06439.6 KOO30932.1 - 0.026 14.4 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) AAA_28 PF13521.1 KOO30932.1 - 0.039 13.9 0.0 0.075 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 KOO30932.1 - 0.04 14.0 0.0 0.11 12.6 0.0 1.8 1 1 0 1 1 1 0 RNA helicase Zeta_toxin PF06414.7 KOO30932.1 - 0.079 12.0 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin DUF743 PF05332.6 KOO30932.1 - 0.08 12.8 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF743) AAA_11 PF13086.1 KOO30932.1 - 0.11 12.0 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 KOO30932.1 - 0.2 10.8 0.1 0.39 9.9 0.1 1.3 1 0 0 1 1 1 0 PhoH-like protein FAD_binding_3 PF01494.14 KOO30933.1 - 5.6e-10 38.7 0.0 7.9e-10 38.3 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain OAF PF14941.1 KOO30935.1 - 0.015 14.4 0.3 0.025 13.7 0.2 1.3 1 0 0 1 1 1 0 Transcriptional regulator, Out at first UbiA PF01040.13 KOO30936.1 - 0.0076 15.4 2.6 0.0076 15.4 1.8 1.8 2 0 0 2 2 2 1 UbiA prenyltransferase family DUF4135 PF13575.1 KOO30936.1 - 0.037 13.0 0.1 0.062 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) Glyco_transf_34 PF05637.7 KOO30936.1 - 0.08 12.4 0.4 0.15 11.4 0.3 1.4 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family SPRY PF00622.23 KOO30937.1 - 0.0011 19.0 0.0 0.0021 18.1 0.0 1.5 1 0 0 1 1 1 1 SPRY domain SpoA PF01052.15 KOO30937.1 - 0.087 12.4 0.0 0.37 10.4 0.0 2.0 2 0 0 2 2 2 0 Surface presentation of antigens (SPOA) NACHT PF05729.7 KOO30938.1 - 0.00059 19.5 0.0 0.0019 17.8 0.0 2.0 2 0 0 2 2 2 1 NACHT domain DUF552 PF04472.7 KOO30938.1 - 0.22 11.4 0.0 0.77 9.7 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF552) HEAT_EZ PF13513.1 KOO30939.1 - 1.9 9.1 7.4 3.8 8.1 0.3 3.2 2 1 0 2 2 2 0 HEAT-like repeat Hydrolase_6 PF13344.1 KOO30940.1 - 0.15 11.9 0.0 2.1 8.2 0.0 2.0 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase CLPTM1 PF05602.7 KOO30941.1 - 4.5e-101 338.7 0.0 3.8e-92 309.3 0.0 2.1 1 1 1 2 2 2 2 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.9 KOO30941.1 - 0.0007 19.0 7.0 0.46 10.0 0.2 3.6 2 1 0 2 2 2 2 PQ loop repeat ECF-ribofla_trS PF07155.7 KOO30941.1 - 0.1 12.3 0.1 0.1 12.3 0.1 1.6 2 0 0 2 2 2 0 ECF-type riboflavin transporter, S component SURF6 PF04935.7 KOO30943.1 - 5.9e-21 74.7 23.8 7.6e-21 74.3 16.5 1.1 1 0 0 1 1 1 1 Surfeit locus protein 6 CAF-1_p150 PF11600.3 KOO30943.1 - 0.12 11.7 22.4 0.17 11.2 15.5 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Peptidase_C2 PF00648.16 KOO30944.1 - 4.7e-72 242.5 0.1 3.5e-38 131.3 0.0 2.7 2 1 0 2 2 2 2 Calpain family cysteine protease Calpain_III PF01067.17 KOO30944.1 - 1.7e-63 212.6 0.0 6e-16 58.4 0.0 5.3 5 0 0 5 5 5 5 Calpain large subunit, domain III EF-hand_5 PF13202.1 KOO30944.1 - 6.9e-05 22.0 1.6 0.27 10.6 0.1 3.1 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO30944.1 - 0.0055 16.8 1.7 0.73 10.0 0.3 3.5 3 1 2 5 5 5 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO30944.1 - 0.093 12.6 3.2 12 6.1 0.2 3.3 1 1 1 2 2 2 0 EF-hand domain EF-hand_1 PF00036.27 KOO30944.1 - 0.23 10.8 11.7 0.16 11.3 0.1 4.1 3 1 1 4 4 4 0 EF hand Aa_trans PF01490.13 KOO30945.1 - 1.8e-38 132.1 24.4 2.2e-38 131.8 16.9 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Mlf1IP PF10248.4 KOO30947.1 - 5.9e-07 29.2 0.8 1e-06 28.5 0.5 1.4 1 0 0 1 1 1 1 Myelodysplasia-myeloid leukemia factor 1-interacting protein BRO1 PF03097.13 KOO30948.1 - 6.3e-27 94.3 0.6 7.2e-27 94.1 0.4 1.1 1 0 0 1 1 1 1 BRO1-like domain DOG1 PF14144.1 KOO30948.1 - 0.058 13.4 0.2 0.2 11.6 0.0 2.0 2 1 0 2 2 2 0 Seed dormancy control Sel1 PF08238.7 KOO30948.1 - 0.11 13.2 3.6 8.3 7.1 0.8 3.4 2 1 1 3 3 3 0 Sel1 repeat Sec5 PF15469.1 KOO30948.1 - 0.12 12.0 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Exocyst complex component Sec5 DUF2413 PF10310.4 KOO30949.1 - 0.0034 16.2 6.5 0.0034 16.2 4.5 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2413) PX PF00787.19 KOO30950.1 - 1.8e-11 43.7 0.0 3.8e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 PX domain DUF830 PF05708.7 KOO30950.1 - 3e-05 24.0 0.0 0.15 12.0 0.0 2.3 2 0 0 2 2 2 2 Orthopoxvirus protein of unknown function (DUF830) Y_phosphatase3 PF13350.1 KOO30951.1 - 0.0052 17.0 0.9 0.0052 17.0 0.6 2.2 3 0 0 3 3 3 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 KOO30951.1 - 0.031 13.6 0.3 0.074 12.3 0.1 1.7 2 0 0 2 2 2 0 Protein-tyrosine phosphatase GalP_UDP_transf PF01087.17 KOO30952.1 - 5.9e-13 49.2 0.0 7.8e-12 45.6 0.0 2.2 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, N-terminal domain Fascin PF06268.8 KOO30952.1 - 0.011 15.8 0.0 0.082 13.0 0.0 2.2 1 1 1 2 2 2 0 Fascin domain Tudor-knot PF11717.3 KOO30953.1 - 0.09 12.4 0.0 13 5.5 0.0 2.6 1 1 1 2 2 2 0 RNA binding activity-knot of a chromodomain PABP PF00658.13 KOO30954.1 - 3.2e-13 49.1 0.1 7.8e-13 47.8 0.0 1.7 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain ZZ PF00569.12 KOO30954.1 - 0.012 15.0 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 Zinc finger, ZZ type SPRY PF00622.23 KOO30955.1 - 6.7e-11 42.3 0.1 9.8e-11 41.8 0.0 1.3 1 1 0 1 1 1 1 SPRY domain RHH_2 PF03693.9 KOO30957.1 - 0.089 12.9 1.0 0.57 10.3 0.1 2.0 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0156) PTPS PF01242.14 KOO30959.1 - 8.8e-35 119.0 0.0 1.3e-13 50.6 0.0 3.2 3 0 0 3 3 3 3 6-pyruvoyl tetrahydropterin synthase ADH_zinc_N PF00107.21 KOO30959.1 - 9.7e-11 41.3 0.2 3.4e-10 39.5 0.1 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_18 PF12847.2 KOO30959.1 - 0.00098 19.6 0.4 1.4 9.5 0.0 2.9 2 0 0 2 2 2 2 Methyltransferase domain 2-Hacid_dh_C PF02826.14 KOO30959.1 - 0.028 13.5 0.0 0.052 12.7 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_N PF08240.7 KOO30959.1 - 0.035 13.8 0.0 0.069 12.9 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Glyco_hydro_31 PF01055.21 KOO30961.1 - 8.5e-65 219.2 0.4 5.5e-56 190.2 0.4 2.2 1 1 1 2 2 2 2 Glycosyl hydrolases family 31 Ricin_B_lectin PF00652.17 KOO30961.1 - 2.6e-09 37.1 1.4 8.5e-09 35.4 0.3 2.3 2 1 0 2 2 2 1 Ricin-type beta-trefoil lectin domain Gal_mutarotas_2 PF13802.1 KOO30961.1 - 4.8e-06 26.3 0.6 6e-05 22.8 0.3 2.6 2 0 0 2 2 2 1 Galactose mutarotase-like DUF2403 PF10290.4 KOO30961.1 - 0.024 14.7 0.0 0.062 13.4 0.0 1.6 1 0 0 1 1 1 0 Glycine-rich protein domain (DUF2403) Ank_2 PF12796.2 KOO30962.1 - 1.5e-34 118.1 3.6 2.5e-16 59.7 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO30962.1 - 9.8e-26 89.6 5.5 1.7e-08 34.7 0.0 5.1 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.25 KOO30962.1 - 2.4e-25 87.0 9.1 2.3e-05 23.9 0.2 5.8 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.1 KOO30962.1 - 3.5e-18 63.8 0.3 0.0068 16.5 0.0 5.8 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.1 KOO30962.1 - 9.2e-15 54.3 5.8 0.0008 19.5 0.0 4.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ion_trans PF00520.26 KOO30963.1 - 2.2e-19 69.5 5.7 2.2e-19 69.5 4.0 1.6 2 0 0 2 2 2 1 Ion transport protein EF-hand_1 PF00036.27 KOO30963.1 - 1.5e-18 64.5 6.9 5.9e-07 28.3 0.0 3.7 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.1 KOO30963.1 - 3.7e-18 65.4 2.6 8.9e-11 41.7 0.3 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO30963.1 - 6.7e-18 62.9 6.8 1.2e-06 27.8 0.1 3.9 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.1 KOO30963.1 - 3.8e-16 58.4 5.2 2e-07 30.4 0.4 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO30963.1 - 1.3e-09 36.9 6.3 0.00021 20.4 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_4 PF12763.2 KOO30963.1 - 2.7e-08 33.5 1.9 0.014 15.0 0.0 3.4 2 1 1 3 3 3 3 Cytoskeletal-regulatory complex EF hand Ion_trans_2 PF07885.11 KOO30963.1 - 3.9e-05 23.2 0.4 3.9e-05 23.2 0.3 2.2 2 0 0 2 2 2 1 Ion channel TerB PF05099.8 KOO30963.1 - 0.0015 18.2 0.0 0.18 11.5 0.0 2.5 2 0 0 2 2 2 1 Tellurite resistance protein TerB EF-hand_10 PF14788.1 KOO30963.1 - 0.019 14.6 1.1 1.8 8.3 0.0 2.9 3 0 0 3 3 3 0 EF hand EF-hand_6 PF13405.1 KOO30964.1 - 0.00016 21.2 0.1 0.0035 17.0 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 KOO30964.1 - 0.00065 18.8 0.3 0.016 14.4 0.0 2.7 2 1 0 2 2 2 1 EF hand EF-hand_5 PF13202.1 KOO30964.1 - 0.0033 16.6 2.2 0.0071 15.6 0.0 2.3 2 1 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO30964.1 - 0.0047 17.0 0.1 0.051 13.7 0.0 1.9 1 1 1 2 2 2 1 EF-hand domain pair Phage_integrase PF00589.17 KOO30966.1 - 4.1e-07 29.8 0.0 0.00012 21.8 0.0 2.4 2 0 0 2 2 2 2 Phage integrase family WD40 PF00400.27 KOO30968.1 - 8.5e-100 323.4 54.4 1.7e-12 46.6 0.4 10.3 10 0 0 10 10 10 9 WD domain, G-beta repeat PD40 PF07676.7 KOO30968.1 - 3.1e-20 71.3 6.7 0.9 9.2 0.0 8.7 8 0 0 8 8 8 8 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOO30968.1 - 1.3e-13 51.1 3.6 0.00019 21.2 0.0 4.5 1 1 3 5 5 5 5 Eukaryotic translation initiation factor eIF2A LigD_N PF13298.1 KOO30968.1 - 3.5e-06 27.0 7.7 17 5.5 0.1 8.0 1 1 5 7 7 7 0 DNA polymerase Ligase (LigD) DUF3892 PF13031.1 KOO30968.1 - 1.7e-05 25.1 5.4 0.071 13.5 0.1 4.7 3 1 2 5 5 5 1 Protein of unknown function (DUF3892) DUF1513 PF07433.6 KOO30968.1 - 3.4e-05 22.9 7.3 0.42 9.4 0.0 5.3 1 1 4 5 5 5 2 Protein of unknown function (DUF1513) DUF3312 PF11768.3 KOO30968.1 - 0.00014 20.2 0.0 3.1 5.9 0.0 4.3 1 1 6 7 7 7 2 Protein of unknown function (DUF3312) CPSF_A PF03178.10 KOO30968.1 - 0.0028 16.8 0.1 4.6 6.2 0.0 3.9 2 2 1 3 3 3 1 CPSF A subunit region IKI3 PF04762.7 KOO30968.1 - 0.0033 15.3 2.1 0.12 10.1 0.5 3.3 1 1 2 3 3 3 1 IKI3 family Flt3_lig PF02947.9 KOO30968.1 - 0.097 12.5 0.0 83 3.0 0.0 3.9 4 1 0 4 4 4 0 flt3 ligand DUF4467 PF14729.1 KOO30968.1 - 0.16 12.2 0.0 1.4e+02 2.8 0.0 4.5 2 1 2 5 5 5 0 Domain of unknown function with cystatin-like fold (DUF4467) Glyco_transf_15 PF01793.11 KOO30970.1 - 1.1e-14 54.0 0.0 2.1e-14 53.2 0.0 1.4 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Myb_DNA-binding PF00249.26 KOO30972.1 - 4.8e-22 77.7 0.1 5.2e-10 39.2 0.1 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO30972.1 - 8.3e-22 77.0 0.1 2.3e-15 56.4 0.0 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain Sigma70_r4_2 PF08281.7 KOO30972.1 - 0.03 13.7 0.0 0.067 12.6 0.0 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 Myb_DNA-bind_2 PF08914.6 KOO30972.1 - 0.084 12.6 0.2 4.3 7.2 0.0 3.3 3 2 0 3 3 3 0 Rap1 Myb domain Chloroa_b-bind PF00504.16 KOO30973.1 - 7.9e-13 48.9 0.2 9.2e-13 48.7 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein DUF4079 PF13301.1 KOO30974.1 - 1.9e-45 155.0 0.4 3.3e-45 154.2 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4079) MerR-DNA-bind PF09278.6 KOO30974.1 - 0.0038 17.5 0.2 0.0075 16.6 0.2 1.4 1 0 0 1 1 1 1 MerR, DNA binding DivIC PF04977.10 KOO30974.1 - 0.11 12.0 1.0 4.1 6.9 0.0 2.6 3 0 0 3 3 3 0 Septum formation initiator Phage_GP20 PF06810.6 KOO30974.1 - 0.11 11.8 0.0 0.16 11.4 0.0 1.1 1 0 0 1 1 1 0 Phage minor structural protein GP20 HR1 PF02185.11 KOO30974.1 - 0.15 11.8 0.1 0.49 10.1 0.0 1.8 1 1 1 2 2 2 0 Hr1 repeat Seryl_tRNA_N PF02403.17 KOO30974.1 - 0.19 11.7 0.4 0.39 10.7 0.2 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DHC_N2 PF08393.8 KOO30978.1 - 7.4e-46 156.4 0.7 2.8e-45 154.5 0.0 2.0 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 DUF4160 PF13711.1 KOO30978.1 - 0.11 12.3 0.2 0.3 10.9 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4160) Suf PF05843.9 KOO30979.1 - 9.8e-30 104.2 0.0 2e-13 50.7 0.0 4.0 4 1 0 4 4 4 2 Suppressor of forked protein (Suf) TPR_19 PF14559.1 KOO30979.1 - 0.00055 20.2 3.1 0.17 12.2 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO30979.1 - 0.015 15.8 2.6 0.041 14.5 0.8 8.9 5 4 7 12 12 12 0 Tetratricopeptide repeat TPR_11 PF13414.1 KOO30979.1 - 0.038 13.6 0.0 0.54 9.9 0.0 2.6 2 0 0 2 2 2 0 TPR repeat Eno-Rase_NADH_b PF12242.3 KOO30979.1 - 0.15 11.8 0.7 0.29 10.9 0.5 1.4 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF3661 PF12400.3 KOO30980.1 - 6.7e-27 94.1 2.8 9.3e-27 93.6 2.0 1.2 1 0 0 1 1 1 1 Vaculolar membrane protein Nucleotid_trans PF03407.11 KOO30981.1 - 1.2e-32 113.4 0.0 1.6e-32 113.0 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase ClpS PF02617.12 KOO30982.1 - 1.6e-15 56.5 0.3 2.4e-15 56.0 0.2 1.2 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS DUF900 PF05990.7 KOO30982.1 - 3.5e-05 23.2 0.1 4.5e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) PCI_Csn8 PF10075.4 KOO30984.1 - 8.9e-09 35.2 0.1 1.4e-08 34.6 0.1 1.3 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 Oxidored_FMN PF00724.15 KOO30985.1 - 1.5e-73 247.7 0.0 8.7e-73 245.2 0.0 1.9 1 1 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Pyr_redox_2 PF07992.9 KOO30985.1 - 1.1e-16 61.3 0.8 2e-11 44.1 0.0 3.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOO30985.1 - 2.9e-15 56.8 1.7 5.7e-12 46.1 1.2 3.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOO30985.1 - 2.1e-08 34.4 6.0 0.03 14.7 0.3 5.2 4 1 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 KOO30985.1 - 6.3e-07 29.3 8.0 3.1e-05 23.9 1.6 3.2 2 1 0 2 2 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 KOO30985.1 - 0.00097 18.0 7.2 0.1 11.4 1.0 3.1 3 0 0 3 3 3 2 FAD binding domain Amino_oxidase PF01593.19 KOO30985.1 - 0.001 18.2 0.0 0.002 17.2 0.0 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Thi4 PF01946.12 KOO30985.1 - 0.0031 16.6 3.2 0.33 10.0 0.1 3.6 3 1 1 4 4 4 1 Thi4 family FAD_oxidored PF12831.2 KOO30985.1 - 0.0034 16.5 7.1 0.042 12.9 0.1 2.3 1 1 1 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.9 KOO30985.1 - 0.0096 14.4 14.7 0.071 11.5 0.0 3.7 4 1 1 5 5 5 2 HI0933-like protein DAO PF01266.19 KOO30985.1 - 0.011 14.6 14.8 0.036 12.9 2.6 4.7 3 1 1 4 4 4 0 FAD dependent oxidoreductase K_oxygenase PF13434.1 KOO30985.1 - 0.016 14.1 0.0 3.3 6.5 0.0 2.3 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_Gly3P_dh_N PF01210.18 KOO30985.1 - 0.04 13.6 2.6 8.2 6.1 1.0 3.3 2 1 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_binding_3 PF01494.14 KOO30985.1 - 0.055 12.5 1.2 1.5 7.8 0.1 2.4 2 0 0 2 2 2 0 FAD binding domain Dus PF01207.12 KOO30985.1 - 0.08 11.7 0.0 0.2 10.4 0.0 1.7 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) Lycopene_cycl PF05834.7 KOO30985.1 - 0.2 10.5 0.5 0.53 9.1 0.4 1.7 1 1 0 1 1 1 0 Lycopene cyclase protein ThiF PF00899.16 KOO30985.1 - 0.3 10.9 3.4 1.4 8.7 0.4 3.0 3 0 0 3 3 3 0 ThiF family CoA_binding PF02629.14 KOO30985.1 - 0.3 11.6 2.3 33 5.0 0.1 3.6 3 0 0 3 3 3 0 CoA binding domain NAD_binding_9 PF13454.1 KOO30985.1 - 0.38 10.5 5.9 0.68 9.7 0.1 3.5 3 1 0 4 4 4 0 FAD-NAD(P)-binding GIDA PF01134.17 KOO30985.1 - 2.2 7.0 5.8 28 3.3 4.0 2.3 1 1 0 1 1 1 0 Glucose inhibited division protein A 3HCDH_N PF02737.13 KOO30985.1 - 4.9 6.7 7.1 31 4.1 0.3 3.3 2 1 1 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Bacteriocin_IIc PF10439.4 KOO30985.1 - 8 6.6 15.9 6.3 7.0 3.7 3.3 3 0 0 3 3 2 0 Bacteriocin class II with double-glycine leader peptide ATPgrasp_ST PF14397.1 KOO30986.1 - 9e-06 24.9 0.0 1.5e-05 24.2 0.0 1.3 1 1 0 1 1 1 1 Sugar-transfer associated ATP-grasp TPR_7 PF13176.1 KOO30988.1 - 1.1e-06 27.9 4.8 0.094 12.5 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO30988.1 - 0.0025 17.7 5.4 0.013 15.3 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO30988.1 - 0.0037 17.7 0.0 1.6 9.5 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO30988.1 - 0.019 14.7 3.5 0.55 10.1 0.0 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO30988.1 - 0.088 13.3 0.7 14 6.3 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_20 PF14561.1 KOO30988.1 - 0.09 12.9 0.3 0.39 10.8 0.1 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.1 KOO30988.1 - 0.13 11.8 0.8 0.68 9.6 0.1 2.5 2 1 0 2 2 2 0 TPR repeat PPR PF01535.15 KOO30988.1 - 0.22 11.6 1.2 14 5.8 0.1 2.7 2 0 0 2 2 2 0 PPR repeat DUF1910 PF08928.5 KOO30988.1 - 0.71 9.9 4.7 3.1 7.8 3.3 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF1910) Methyltransf_21 PF05050.7 KOO30989.1 - 3.3e-09 36.9 0.0 5.1e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase FkbM domain DUF3011 PF11218.3 KOO30989.1 - 0.00031 20.5 2.7 0.00071 19.4 1.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3011) DUF3437 PF11919.3 KOO30990.1 - 3e-27 94.1 2.2 7.8e-27 92.8 0.0 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF3437) PDZ_2 PF13180.1 KOO30996.1 - 3.1e-17 62.2 0.0 1e-07 31.7 0.0 2.4 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.19 KOO30996.1 - 8.6e-17 61.0 0.0 5.6e-07 29.6 0.0 2.4 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) Lig_chan PF00060.21 KOO30996.1 - 8.9e-08 31.9 0.1 1.5e-07 31.2 0.1 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel Tricorn_PDZ PF14685.1 KOO30996.1 - 3.8e-06 26.6 0.0 0.024 14.3 0.0 2.4 2 0 0 2 2 2 2 Tricorn protease PDZ domain GRASP55_65 PF04495.9 KOO30996.1 - 6.7e-05 22.8 0.0 0.56 10.1 0.0 2.7 3 0 0 3 3 3 2 GRASP55/65 PDZ-like domain Aldo_ket_red PF00248.16 KOO30997.1 - 3e-23 82.0 0.0 4.7e-23 81.4 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family HTH_5 PF01022.15 KOO30997.1 - 0.12 12.0 0.1 19 5.0 0.0 2.5 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family Methyltransf_16 PF10294.4 KOO30998.1 - 2e-27 95.7 0.0 2.6e-27 95.3 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_26 PF13659.1 KOO30998.1 - 1.8e-06 27.9 0.6 3.1e-06 27.2 0.4 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO30998.1 - 2.9e-05 24.6 0.0 5.1e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 KOO30998.1 - 8.3e-05 21.8 0.0 0.00011 21.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 KOO30998.1 - 0.00015 21.2 0.0 0.00023 20.6 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.7 KOO30998.1 - 0.017 15.6 0.0 0.034 14.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DUF4586 PF15239.1 KOO30999.1 - 2.9e-09 36.8 0.1 5.2e-09 36.0 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4586) Siva PF05458.7 KOO30999.1 - 0.15 11.6 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Cd27 binding protein (Siva) Dpy-30 PF05186.8 KOO31000.1 - 1.5e-18 65.9 0.1 3.3e-18 64.8 0.1 1.6 1 0 0 1 1 1 1 Dpy-30 motif Epimerase PF01370.16 KOO31000.1 - 3.6e-05 23.3 0.0 0.00077 18.9 0.0 2.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family ADK PF00406.17 KOO31000.1 - 0.00031 20.6 0.0 0.00084 19.2 0.0 1.7 2 0 0 2 2 2 1 Adenylate kinase PsbP PF01789.11 KOO31001.1 - 2.3e-06 27.1 0.0 3e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 PsbP Beach PF02138.13 KOO31002.1 - 8.8e-87 290.9 0.0 9.8e-87 290.8 0.0 1.0 1 0 0 1 1 1 1 Beige/BEACH domain EF-hand_1 PF00036.27 KOO31004.1 - 1.9e-09 36.1 0.0 0.0016 17.6 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO31004.1 - 1.2e-07 31.2 0.3 0.0057 16.2 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO31004.1 - 6.5e-06 25.6 0.1 0.099 12.5 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO31004.1 - 0.00013 22.0 0.1 0.0019 18.2 0.0 2.6 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO31004.1 - 0.00019 20.5 1.2 0.57 9.6 0.0 3.2 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.4 KOO31004.1 - 0.00064 19.7 0.6 0.0059 16.6 0.0 2.6 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Drc1-Sld2 PF11719.3 KOO31004.1 - 0.015 14.4 0.4 0.21 10.6 0.2 2.0 2 0 0 2 2 2 0 DNA replication and checkpoint protein Mpp10 PF04006.7 KOO31004.1 - 0.02 13.2 0.1 0.033 12.5 0.0 1.3 1 0 0 1 1 1 0 Mpp10 protein Hemerythrin PF01814.18 KOO31004.1 - 0.074 13.2 1.1 0.25 11.5 0.7 2.0 1 1 0 1 1 1 0 Hemerythrin HHE cation binding domain Ketoacyl-synt_C PF02801.17 KOO31005.1 - 1.8e-30 105.1 3.0 5.2e-30 103.7 2.1 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.21 KOO31005.1 - 3.1e-27 95.6 8.8 7.6e-27 94.3 6.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Thioesterase PF00975.15 KOO31005.1 - 5.1e-09 36.7 0.2 1.2e-08 35.5 0.1 1.6 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.2 KOO31005.1 - 1.2e-08 35.0 3.4 2.6e-08 34.0 2.3 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF3854 PF12965.2 KOO31006.1 - 0.092 12.3 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3854) PX PF00787.19 KOO31007.1 - 2.5e-22 78.8 0.0 4.1e-22 78.1 0.0 1.4 1 0 0 1 1 1 1 PX domain Vps5 PF09325.5 KOO31007.1 - 9.8e-07 28.2 5.9 0.00031 20.0 4.0 2.4 1 1 0 1 1 1 1 Vps5 C terminal like DUF2094 PF09867.4 KOO31007.1 - 0.036 13.9 0.2 0.098 12.5 0.2 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2094) FlaF PF07309.6 KOO31008.1 - 0.037 13.9 0.2 0.084 12.7 0.1 1.6 1 0 0 1 1 1 0 Flagellar protein FlaF Nuc_sug_transp PF04142.10 KOO31009.1 - 1.7e-12 46.9 1.3 2.4e-12 46.5 0.9 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter Peptidase_A8 PF01252.13 KOO31009.1 - 0.74 9.4 3.4 0.38 10.3 0.3 2.0 2 0 0 2 2 2 0 Signal peptidase (SPase) II EF-hand_1 PF00036.27 KOO31010.1 - 2.4e-16 57.7 0.2 4.6e-08 31.7 0.1 2.3 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO31010.1 - 8.3e-14 50.2 0.1 1e-05 24.6 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO31010.1 - 8.9e-14 50.8 0.4 2e-11 43.3 0.0 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO31010.1 - 1.2e-13 49.6 0.2 1.1e-05 24.8 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO31010.1 - 2.9e-12 46.5 0.0 4.6e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_4 PF12763.2 KOO31010.1 - 0.00019 21.0 0.1 0.0026 17.4 0.1 2.0 1 1 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO31010.1 - 0.00042 20.1 0.0 0.00064 19.5 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_10 PF14788.1 KOO31010.1 - 0.11 12.2 0.1 1.4 8.6 0.0 2.2 1 1 1 2 2 2 0 EF hand BioW PF03744.8 KOO31011.1 - 0.039 13.3 0.3 3.2 7.1 0.0 2.3 2 0 0 2 2 2 0 6-carboxyhexanoate--CoA ligase Ank PF00023.25 KOO31012.1 - 0.11 12.3 1.0 2.2 8.2 0.2 2.2 2 1 0 2 2 2 0 Ankyrin repeat LpxC PF03331.8 KOO31013.1 - 2e-53 181.1 0.0 3.5e-34 118.0 0.0 2.0 2 0 0 2 2 2 2 UDP-3-O-acyl N-acetylglycosamine deacetylase SGS PF05002.10 KOO31014.1 - 7.3e-10 38.4 0.4 1.2e-09 37.7 0.3 1.3 1 0 0 1 1 1 1 SGS domain CS PF04969.11 KOO31014.1 - 3.4e-06 27.5 0.0 5.2e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 CS domain Siah-Interact_N PF09032.6 KOO31014.1 - 0.00077 19.4 0.0 0.0014 18.6 0.0 1.5 1 0 0 1 1 1 1 Siah interacting protein, N terminal FTHFS PF01268.14 KOO31014.1 - 0.11 10.5 0.0 0.15 10.0 0.0 1.1 1 0 0 1 1 1 0 Formate--tetrahydrofolate ligase Abhydrolase_3 PF07859.8 KOO31015.1 - 8.2e-16 58.2 0.2 2e-15 56.9 0.2 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold LRR_8 PF13855.1 KOO31015.1 - 2.8e-09 36.5 0.1 9.6e-09 34.8 0.1 2.0 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.2 KOO31015.1 - 4.6e-09 35.7 0.0 3.4e-06 26.5 0.0 3.0 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) DUF2424 PF10340.4 KOO31015.1 - 2.7e-06 26.2 0.0 4.1e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) LRR_1 PF00560.28 KOO31015.1 - 0.0042 16.9 0.2 2.5 8.4 0.0 4.1 4 0 0 4 4 4 1 Leucine Rich Repeat Lactamase_B_2 PF12706.2 KOO31015.1 - 0.019 14.4 1.2 0.064 12.8 0.2 2.1 2 0 0 2 2 2 0 Beta-lactamase superfamily domain DUF3089 PF11288.3 KOO31015.1 - 0.027 13.6 0.0 0.051 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) PaO PF08417.7 KOO31019.1 - 2.6e-13 49.6 0.0 4.7e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 Pheophorbide a oxygenase Ring_hydroxyl_A PF00848.14 KOO31019.1 - 0.064 12.8 0.0 2 8.0 0.0 2.2 2 0 0 2 2 2 0 Ring hydroxylating alpha subunit (catalytic domain) ABM PF03992.11 KOO31020.1 - 1.1e-18 67.0 0.1 1.4e-18 66.6 0.1 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase Mob1_phocein PF03637.12 KOO31022.1 - 3.3e-60 202.7 0.1 4.3e-60 202.3 0.0 1.1 1 0 0 1 1 1 1 Mob1/phocein family Mpv17_PMP22 PF04117.7 KOO31022.1 - 1.7e-13 49.9 0.7 4.4e-13 48.6 0.5 1.7 1 0 0 1 1 1 1 Mpv17 / PMP22 family DUF3754 PF12576.3 KOO31023.1 - 9e-07 28.6 0.0 1.8e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3754) DAO PF01266.19 KOO31024.1 - 1.1e-14 54.1 0.1 1.9e-14 53.3 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Abi PF02517.11 KOO31026.1 - 2e-14 53.4 5.8 2e-14 53.4 4.0 1.6 1 1 1 2 2 2 1 CAAX protease self-immunity DUF2723 PF11028.3 KOO31026.1 - 0.14 11.6 12.9 0.014 14.9 3.4 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF2723) OGFr_III PF04680.8 KOO31026.1 - 0.68 10.1 5.1 2.1 8.5 3.5 1.8 1 0 0 1 1 1 0 Opioid growth factor receptor repeat EF-hand_1 PF00036.27 KOO31027.1 - 1.8e-21 73.7 6.6 2.8e-06 26.2 0.2 4.2 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO31027.1 - 8e-17 60.5 8.4 4.9e-07 29.2 0.6 3.4 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO31027.1 - 1.5e-15 55.5 3.1 0.0034 17.1 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO31027.1 - 7.8e-13 48.3 5.0 4.3e-05 23.5 1.1 3.3 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO31027.1 - 3e-10 38.9 3.5 0.031 13.6 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_4 PF12763.2 KOO31027.1 - 2e-06 27.4 0.6 0.014 15.1 0.0 2.2 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO31027.1 - 0.1 12.5 0.2 2.3 8.1 0.0 2.8 2 2 1 3 3 3 0 EF-hand domain Galactosyl_T PF01762.16 KOO31028.1 - 0.0034 16.9 0.0 0.01 15.4 0.0 1.8 1 1 0 1 1 1 1 Galactosyltransferase WGG PF10273.4 KOO31029.1 - 4.6e-18 65.0 0.1 8.2e-18 64.2 0.1 1.4 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 4HBT_3 PF13622.1 KOO31029.1 - 1.2 8.7 6.4 0.27 10.9 1.0 1.9 1 1 1 2 2 2 0 Thioesterase-like superfamily TBCC PF07986.7 KOO31030.1 - 1.4e-33 114.7 0.0 2.2e-33 114.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C Glyco_hydro_67M PF07488.7 KOO31030.1 - 0.052 12.4 0.0 0.074 11.9 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 middle domain UPF0506 PF11703.3 KOO31031.1 - 0.13 12.1 0.3 0.35 10.8 0.2 1.6 1 0 0 1 1 1 0 UPF0506 Dynein_light PF01221.13 KOO31032.1 - 6.6e-19 67.7 6.4 1.9e-18 66.1 4.4 1.7 1 1 0 1 1 1 1 Dynein light chain type 1 Glyco_transf_8 PF01501.15 KOO31033.1 - 6.8e-09 35.4 0.0 1.4e-08 34.3 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 8 Glyco_hydro_3 PF00933.16 KOO31034.1 - 9.6e-64 215.2 0.0 1.2e-63 214.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.1 KOO31034.1 - 3.7e-19 68.4 0.0 6.7e-19 67.6 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain HTH_40 PF14493.1 KOO31035.1 - 0.0004 20.5 0.0 0.00054 20.1 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain 7TM-7TMR_HD PF07698.6 KOO31037.1 - 0.0046 16.4 0.7 0.0061 16.0 0.5 1.2 1 0 0 1 1 1 1 7TM receptor with intracellular HD hydrolase Gly-zipper_Omp PF13488.1 KOO31037.1 - 0.034 13.7 0.8 0.034 13.7 0.5 3.1 3 0 0 3 3 3 0 Glycine zipper Phage_holin_3 PF05106.7 KOO31037.1 - 0.034 14.1 3.1 0.071 13.1 0.3 2.3 1 1 1 2 2 2 0 Phage holin family (Lysis protein S) FUN14 PF04930.10 KOO31037.1 - 0.57 10.5 7.2 1.7 8.9 4.9 1.8 1 1 0 1 1 1 0 FUN14 family Gly-zipper_YMGG PF13441.1 KOO31037.1 - 8.2 6.0 15.9 0.27 10.7 1.9 3.1 3 0 0 3 3 3 0 YMGG-like Gly-zipper LRR_5 PF13306.1 KOO31038.1 - 5.5e-53 178.0 0.0 3.6e-28 97.8 0.0 2.0 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO31038.1 - 4.5e-16 58.3 0.0 0.00017 21.2 0.0 4.0 1 1 4 5 5 5 5 Leucine rich repeat He_PIG PF05345.7 KOO31038.1 - 0.0049 16.8 9.2 76 3.4 0.6 6.3 6 1 1 7 7 7 0 Putative Ig domain APC_crr PF05923.7 KOO31038.1 - 2.8 7.6 19.8 0.71 9.5 0.1 6.6 7 0 0 7 7 7 0 APC cysteine-rich region IncA PF04156.9 KOO31040.1 - 0.024 14.2 1.2 0.04 13.5 0.8 1.3 1 0 0 1 1 1 0 IncA protein Circo_capsid PF02443.10 KOO31042.1 - 0.2 11.0 3.2 0.24 10.7 2.2 1.1 1 0 0 1 1 1 0 Circovirus capsid protein Methyltransf_18 PF12847.2 KOO31044.1 - 6.9e-06 26.6 0.0 8.8e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 KOO31044.1 - 0.0015 18.5 0.1 0.0018 18.2 0.1 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.1 KOO31044.1 - 0.0015 18.2 0.0 0.0025 17.5 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO31044.1 - 0.0019 18.2 0.1 0.0028 17.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO31044.1 - 0.0038 16.8 0.0 0.0056 16.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 KOO31044.1 - 0.043 13.3 0.1 0.048 13.2 0.0 1.4 1 1 0 1 1 1 0 Met-10+ like-protein Methyltransf_21 PF05050.7 KOO31044.1 - 0.044 13.7 0.0 0.044 13.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase FkbM domain OMPdecase PF00215.19 KOO31045.1 - 2.5e-24 85.9 0.4 3.4e-24 85.5 0.3 1.1 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family MORN PF02493.15 KOO31049.1 - 3.8e-21 73.5 35.2 5.6e-05 22.6 0.2 9.9 11 0 0 11 11 11 6 MORN repeat FHA PF00498.21 KOO31049.1 - 0.081 13.0 0.1 15 5.8 0.0 2.4 2 0 0 2 2 2 0 FHA domain DUF2576 PF10845.3 KOO31049.1 - 0.091 11.9 0.0 0.21 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2576) SM-ATX PF14438.1 KOO31049.1 - 0.52 10.2 8.6 12 5.9 0.0 5.2 6 0 0 6 6 6 0 Ataxin 2 SM domain TPR_11 PF13414.1 KOO31050.1 - 4.7e-06 26.1 0.1 1.6e-05 24.4 0.0 2.0 1 0 0 1 1 1 1 TPR repeat TPR_2 PF07719.12 KOO31050.1 - 4.6e-05 23.0 0.2 0.12 12.3 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO31050.1 - 0.0011 19.6 7.0 0.0011 19.6 4.8 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO31050.1 - 0.0058 16.2 0.0 1.8 8.2 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat MscS_porin PF12795.2 KOO31050.1 - 0.045 13.0 0.0 0.075 12.3 0.0 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain TPR_17 PF13431.1 KOO31050.1 - 0.061 13.5 0.0 0.31 11.3 0.0 2.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO31050.1 - 1 9.2 10.7 0.14 12.0 3.1 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 KOO31050.1 - 4.1 7.8 8.7 0.8 10.0 2.3 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat ABC_tran PF00005.22 KOO31051.1 - 5.4e-52 175.7 0.7 1.1e-28 100.1 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC_tran_2 PF12848.2 KOO31051.1 - 5e-18 64.7 9.5 6.4e-13 48.3 0.6 3.4 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.1 KOO31051.1 - 1.7e-17 64.3 2.9 3.2e-05 24.0 0.0 4.3 2 2 1 4 4 4 3 AAA domain SMC_N PF02463.14 KOO31051.1 - 2.7e-10 39.8 1.0 0.00016 20.9 0.1 4.3 3 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 KOO31051.1 - 9.4e-10 38.7 1.8 3.2e-05 23.9 0.2 2.7 3 0 0 3 3 2 2 AAA ATPase domain AAA_18 PF13238.1 KOO31051.1 - 9.4e-09 35.6 0.8 0.0029 17.9 0.0 3.8 3 1 0 3 3 3 2 AAA domain AAA_17 PF13207.1 KOO31051.1 - 1.3e-08 35.6 0.3 0.01 16.6 0.0 3.3 3 1 0 3 3 2 2 AAA domain Dynamin_N PF00350.18 KOO31051.1 - 3.5e-08 33.4 0.1 0.00021 21.1 0.0 3.0 2 1 1 3 3 3 2 Dynamin family AAA_29 PF13555.1 KOO31051.1 - 6e-08 32.0 0.0 0.0038 16.7 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain Miro PF08477.8 KOO31051.1 - 5e-07 30.2 0.0 0.0014 19.1 0.0 2.9 2 0 0 2 2 2 1 Miro-like protein AAA_30 PF13604.1 KOO31051.1 - 7.9e-07 28.8 0.5 0.0047 16.5 0.1 3.2 2 2 0 2 2 2 2 AAA domain AAA_23 PF13476.1 KOO31051.1 - 1.1e-06 29.1 8.0 0.0066 16.7 0.0 4.4 5 0 0 5 5 4 1 AAA domain AAA_15 PF13175.1 KOO31051.1 - 3.8e-06 26.2 1.1 3 6.8 0.0 4.8 4 1 0 4 4 4 0 AAA ATPase domain AAA_22 PF13401.1 KOO31051.1 - 7.4e-06 26.1 0.2 0.066 13.3 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_13 PF13166.1 KOO31051.1 - 1.3e-05 23.8 2.0 0.97 7.8 0.0 3.9 4 1 0 4 4 4 2 AAA domain DUF258 PF03193.11 KOO31051.1 - 0.00012 21.3 0.0 0.12 11.5 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_14 PF13173.1 KOO31051.1 - 0.00018 21.3 0.1 0.17 11.8 0.0 3.5 3 1 0 3 3 2 1 AAA domain cobW PF02492.14 KOO31051.1 - 0.00019 20.9 0.1 1.3 8.4 0.0 3.3 3 0 0 3 3 3 2 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.7 KOO31051.1 - 0.00025 20.7 0.0 0.4 10.3 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_33 PF13671.1 KOO31051.1 - 0.00026 20.8 0.0 0.52 10.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.18 KOO31051.1 - 0.0003 20.7 0.0 0.059 13.3 0.0 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase DUF87 PF01935.12 KOO31051.1 - 0.00035 20.4 0.6 0.89 9.3 0.0 3.8 4 0 0 4 4 4 1 Domain of unknown function DUF87 AAA PF00004.24 KOO31051.1 - 0.00047 20.3 0.0 0.51 10.5 0.0 2.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MobB PF03205.9 KOO31051.1 - 0.00053 19.7 0.0 1.6 8.4 0.0 2.8 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B ArgK PF03308.11 KOO31051.1 - 0.00056 18.7 1.2 0.17 10.6 0.0 2.8 3 0 0 3 3 3 1 ArgK protein Arch_ATPase PF01637.13 KOO31051.1 - 0.00066 19.4 0.4 0.78 9.3 0.0 2.8 3 0 0 3 3 3 1 Archaeal ATPase AAA_28 PF13521.1 KOO31051.1 - 0.00084 19.3 4.4 0.32 10.9 0.0 3.3 3 1 0 3 3 3 2 AAA domain UPF0079 PF02367.12 KOO31051.1 - 0.001 18.6 0.1 0.24 11.0 0.0 2.8 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 FtsK_SpoIIIE PF01580.13 KOO31051.1 - 0.0025 17.3 0.3 2 7.8 0.0 2.9 3 1 0 3 3 3 1 FtsK/SpoIIIE family SbcCD_C PF13558.1 KOO31051.1 - 0.0033 17.3 0.0 3.3 7.6 0.0 3.3 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_10 PF12846.2 KOO31051.1 - 0.0051 16.2 2.3 0.076 12.4 0.0 3.1 2 2 1 3 3 3 1 AAA-like domain AAA_19 PF13245.1 KOO31051.1 - 0.0055 16.4 0.0 2.3 8.0 0.0 3.0 2 0 0 2 2 2 1 Part of AAA domain Zeta_toxin PF06414.7 KOO31051.1 - 0.0062 15.6 2.6 1 8.4 0.0 3.1 4 0 0 4 4 3 1 Zeta toxin ATG16 PF08614.6 KOO31051.1 - 0.0065 16.3 2.1 0.0065 16.3 1.4 2.5 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) NB-ARC PF00931.17 KOO31051.1 - 0.0077 15.1 0.0 0.28 9.9 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain Thymidylate_kin PF02223.12 KOO31051.1 - 0.0081 15.5 1.7 0.2 10.9 0.0 2.9 3 0 0 3 3 2 1 Thymidylate kinase AAA_24 PF13479.1 KOO31051.1 - 0.01 15.4 0.0 4.4 6.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.17 KOO31051.1 - 0.015 14.7 0.0 0.43 9.9 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain GTP_EFTU PF00009.22 KOO31051.1 - 0.017 14.5 0.0 1.1 8.6 0.0 3.3 3 1 1 4 4 4 0 Elongation factor Tu GTP binding domain ATP-synt_ab PF00006.20 KOO31051.1 - 0.028 13.9 0.0 4.2 6.7 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_25 PF13481.1 KOO31051.1 - 0.031 13.6 4.1 3.1 7.1 0.0 4.0 3 3 2 5 5 3 0 AAA domain RNA_helicase PF00910.17 KOO31051.1 - 0.04 14.0 0.1 13 6.0 0.0 3.0 3 0 0 3 3 2 0 RNA helicase PduV-EutP PF10662.4 KOO31051.1 - 0.055 12.9 0.4 11 5.5 0.0 2.8 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.10 KOO31051.1 - 0.065 12.9 0.0 19 4.9 0.0 2.8 2 0 0 2 2 2 0 NTPase DUF1436 PF07262.6 KOO31051.1 - 0.067 12.6 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1436) DUF503 PF04456.7 KOO31051.1 - 0.085 12.4 1.3 9 5.9 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF503) DUF4615 PF15393.1 KOO31051.1 - 0.097 12.9 1.7 6 7.1 0.1 2.9 3 0 0 3 3 2 0 Domain of unknown function (DUF4615) DUF3584 PF12128.3 KOO31051.1 - 2 5.6 17.5 0.21 8.8 0.3 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF3584) DUF4200 PF13863.1 KOO31051.1 - 3.7 7.5 11.6 0.092 12.6 1.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) BEX PF04538.7 KOO31051.1 - 4.3 7.6 8.8 0.44 10.7 0.2 2.8 3 0 0 3 3 2 0 Brain expressed X-linked like family Enkurin PF13864.1 KOO31052.1 - 0.64 10.2 4.2 0.96 9.6 2.0 1.9 2 1 0 2 2 2 0 Calmodulin-binding Ank_2 PF12796.2 KOO31054.1 - 4.9e-36 122.9 6.2 4.9e-17 62.0 0.3 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO31054.1 - 2.4e-31 105.9 1.4 1.5e-08 34.0 0.0 5.4 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.1 KOO31054.1 - 3.2e-19 68.5 0.5 8.3e-10 38.5 0.0 5.6 2 2 4 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO31054.1 - 3.6e-19 66.9 0.2 0.00011 22.0 0.0 5.5 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.1 KOO31054.1 - 3.8e-17 62.3 0.1 1.7e-05 25.2 0.0 3.6 2 1 2 4 4 4 4 Ankyrin repeats (many copies) DUF1843 PF08898.5 KOO31054.1 - 0.13 12.2 4.0 7.2 6.7 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1843) Ank_2 PF12796.2 KOO31055.1 - 6.6e-69 228.3 24.3 1.9e-17 63.3 0.3 8.2 6 1 2 8 8 8 7 Ankyrin repeats (3 copies) Ank PF00023.25 KOO31055.1 - 9e-57 186.1 30.8 4.3e-06 26.2 0.0 13.1 13 0 0 13 13 12 11 Ankyrin repeat Ank_4 PF13637.1 KOO31055.1 - 1.7e-46 155.7 7.4 3.1e-09 37.0 0.0 9.0 6 2 2 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO31055.1 - 5.3e-43 144.0 23.2 1.6e-07 31.3 0.4 11.3 6 3 6 12 12 11 11 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO31055.1 - 3.9e-39 128.7 20.3 0.0036 17.4 0.0 13.2 12 0 0 12 12 12 11 Ankyrin repeat ART PF01129.13 KOO31055.1 - 1.3e-05 24.4 0.0 3.3e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.9 KOO31055.1 - 0.00018 20.7 0.0 0.0004 19.6 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Thioredoxin PF00085.15 KOO31055.1 - 0.0042 16.7 0.0 0.019 14.6 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_7 PF13899.1 KOO31055.1 - 0.025 14.5 0.0 0.083 12.9 0.0 1.9 1 0 0 1 1 1 0 Thioredoxin-like RGS-like PF09128.6 KOO31055.1 - 0.039 13.4 0.4 0.13 11.7 0.0 2.0 2 0 0 2 2 2 0 Regulator of G protein signalling-like domain DUF3881 PF12997.2 KOO31055.1 - 0.23 10.4 4.1 0.45 9.4 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function, E. rectale Gene description (DUF3881) Peptidase_M3 PF01432.15 KOO31056.1 - 5.5e-61 207.0 1.1 8.1e-41 140.5 0.0 3.2 1 1 2 3 3 3 3 Peptidase family M3 AhpC-TSA PF00578.16 KOO31057.1 - 3.7e-09 36.3 0.0 9.5e-09 34.9 0.0 1.6 1 0 0 1 1 1 1 AhpC/TSA family CsgE PF10627.4 KOO31057.1 - 0.6 9.9 3.1 1.6 8.5 0.1 3.2 2 0 0 2 2 2 0 Curli assembly protein CsgE Glyco_transf_49 PF13896.1 KOO31058.1 - 7e-26 91.0 0.0 7.8e-24 84.3 0.0 2.1 2 0 0 2 2 2 2 Glycosyl-transferase for dystroglycan RCC1 PF00415.13 KOO31059.1 - 3.2e-58 193.7 17.9 2e-10 40.7 0.3 7.6 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.26 KOO31059.1 - 1.2e-17 63.9 0.0 1.5e-07 31.3 0.0 3.5 2 2 1 3 3 3 2 BTB/POZ domain RCC1_2 PF13540.1 KOO31059.1 - 2.9e-15 55.4 56.3 9.4e-06 25.1 3.6 8.7 8 1 0 8 8 8 5 Regulator of chromosome condensation (RCC1) repeat EF-hand_1 PF00036.27 KOO31060.1 - 7.4e-16 56.1 0.1 0.019 14.2 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO31060.1 - 2.4e-14 51.8 0.3 0.037 13.9 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO31060.1 - 1.2e-13 50.9 0.0 8e-06 25.9 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO31060.1 - 5.2e-13 47.6 0.5 0.024 13.9 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO31060.1 - 8.3e-08 31.7 0.1 1.5 8.5 0.0 4.3 4 0 0 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO31060.1 - 0.022 14.7 0.0 0.14 12.1 0.0 2.2 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Pex19 PF04614.7 KOO31060.1 - 0.047 13.3 1.3 0.16 11.5 0.2 2.0 1 1 1 2 2 2 0 Pex19 protein family EF-hand_10 PF14788.1 KOO31060.1 - 0.059 13.0 0.0 10 5.8 0.0 3.2 4 0 0 4 4 4 0 EF hand QRPTase_C PF01729.14 KOO31060.1 - 0.11 11.9 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain HALZ PF02183.13 KOO31061.1 - 0.034 13.8 1.2 0.034 13.8 0.9 4.4 3 2 2 5 5 5 0 Homeobox associated leucine zipper DUF4604 PF15377.1 KOO31061.1 - 2.3 8.3 18.3 4.8 7.3 12.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4604) GSH-S_N PF02951.9 KOO31061.1 - 4 7.2 7.3 14 5.5 0.3 2.6 2 1 0 2 2 2 0 Prokaryotic glutathione synthetase, N-terminal domain DUF1875 PF08961.5 KOO31061.1 - 5.6 6.2 17.4 0.31 10.3 1.1 2.6 2 2 0 2 2 2 0 Domain of unknown function (DUF1875) TPT PF03151.11 KOO31062.1 - 3.1e-16 59.3 12.3 3.1e-16 59.3 8.5 2.5 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 KOO31062.1 - 2.4e-09 37.2 17.8 2.4e-06 27.6 1.7 3.3 3 1 1 4 4 4 2 EamA-like transporter family UAA PF08449.6 KOO31062.1 - 4.9e-06 25.6 24.3 1.3e-05 24.3 16.9 1.6 1 1 0 1 1 1 1 UAA transporter family EmrE PF13536.1 KOO31062.1 - 0.0025 17.9 1.7 0.0025 17.9 1.2 3.9 1 1 2 4 4 4 1 Multidrug resistance efflux transporter Sulfotransfer_3 PF13469.1 KOO31063.1 - 0.94 10.4 13.6 5.3 7.9 9.4 2.4 1 1 0 1 1 1 0 Sulfotransferase family EF-hand_1 PF00036.27 KOO31066.1 - 2.7e-16 57.5 0.9 1.3e-06 27.2 0.0 3.2 3 0 0 3 3 3 2 EF hand Helicase_C PF00271.26 KOO31066.1 - 3.2e-12 46.1 0.0 7.1e-12 45.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain EF-hand_8 PF13833.1 KOO31066.1 - 9.2e-12 44.3 0.5 9.2e-12 44.3 0.3 2.8 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_7 PF13499.1 KOO31066.1 - 1e-11 44.7 0.2 3.3e-11 43.1 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO31066.1 - 2.2e-11 42.6 0.2 7.1e-05 22.3 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.1 KOO31066.1 - 9.4e-09 34.2 2.8 0.00017 20.7 0.0 3.0 2 1 0 2 2 2 2 EF hand EF-hand_9 PF14658.1 KOO31066.1 - 3.4e-05 23.6 0.0 6.4e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO31066.1 - 0.0082 16.1 0.0 0.13 12.2 0.0 2.4 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO31066.1 - 0.033 13.9 0.0 0.067 12.9 0.0 1.4 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand HHH_5 PF14520.1 KOO31067.1 - 0.014 15.5 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix domain BAF PF02961.9 KOO31067.1 - 0.076 13.3 0.0 0.096 13.0 0.0 1.3 1 0 0 1 1 1 0 Barrier to autointegration factor DNA_pol_lambd_f PF10391.4 KOO31067.1 - 0.092 12.3 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda HHH_8 PF14716.1 KOO31067.1 - 0.11 12.7 0.2 0.24 11.6 0.1 1.6 2 0 0 2 2 2 0 Helix-hairpin-helix domain GST_N PF02798.15 KOO31068.1 - 0.00013 22.0 0.0 0.00058 19.9 0.0 2.1 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Methyltransf_16 PF10294.4 KOO31070.1 - 4.5e-12 45.7 0.0 6.2e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase VPS11_C PF12451.3 KOO31071.1 - 1.3e-06 28.1 0.0 2.4e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-C3HC4_2 PF13923.1 KOO31071.1 - 0.064 13.2 8.6 0.18 11.8 5.9 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Clathrin PF00637.15 KOO31071.1 - 0.074 12.6 0.0 0.18 11.3 0.0 1.7 1 0 0 1 1 1 0 Region in Clathrin and VPS zf-RING_2 PF13639.1 KOO31071.1 - 0.11 12.3 10.9 0.26 11.1 7.6 1.7 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.1 KOO31071.1 - 0.16 11.7 8.8 0.39 10.4 6.1 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.20 KOO31071.1 - 1.9 8.2 9.0 4.2 7.1 6.3 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF393 PF04134.7 KOO31071.1 - 3.4 8.8 6.8 96 4.1 0.1 4.0 2 1 1 3 3 3 0 Protein of unknown function, DUF393 DnaJ PF00226.26 KOO31072.1 - 4.6e-18 64.7 0.1 4.6e-18 64.7 0.0 2.3 2 0 0 2 2 2 1 DnaJ domain Myb_DNA-binding PF00249.26 KOO31072.1 - 3.8e-12 46.0 0.3 9.6e-06 25.5 0.1 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO31072.1 - 4.2e-06 26.7 0.1 0.019 15.0 0.0 3.0 3 0 0 3 3 3 2 Myb-like DNA-binding domain GTPase_Cys_C PF12631.2 KOO31073.1 - 2.1 8.7 4.9 33 4.9 0.5 2.8 3 0 0 3 3 3 0 Catalytic cysteine-containing C-terminus of GTPase, MnmE Ion_trans PF00520.26 KOO31074.1 - 9.6e-31 106.5 18.1 1.4e-30 106.0 12.6 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.7 KOO31074.1 - 0.00083 17.8 3.9 0.00083 17.8 2.7 2.1 2 0 0 2 2 2 2 Polycystin cation channel DUF423 PF04241.10 KOO31075.1 - 0.18 11.7 1.7 0.33 10.9 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF423) DUF2207 PF09972.4 KOO31075.1 - 1.8 7.0 3.6 2 6.8 2.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) TraG_N PF07916.6 KOO31075.1 - 2.2 6.6 5.6 2.6 6.3 3.9 1.1 1 0 0 1 1 1 0 TraG-like protein, N-terminal region V_ATPase_I PF01496.14 KOO31076.1 - 0.063 11.1 11.5 0.079 10.8 8.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Basic PF01586.11 KOO31076.1 - 2 9.1 4.7 40 5.0 0.1 2.9 2 1 0 2 2 2 0 Myogenic Basic domain Glyco_tranf_2_4 PF13704.1 KOO31077.1 - 0.032 14.5 0.0 0.1 12.8 0.0 1.9 2 0 0 2 2 2 0 Glycosyl transferase family 2 Ank_2 PF12796.2 KOO31079.1 - 6.1e-50 167.5 9.7 3.3e-18 65.7 0.1 3.1 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 KOO31079.1 - 3.1e-27 92.9 10.1 5.3e-07 29.1 0.0 5.8 6 1 1 7 7 7 5 Ankyrin repeat Ank_4 PF13637.1 KOO31079.1 - 2e-21 75.8 0.0 1.8e-07 31.4 0.0 4.0 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO31079.1 - 3.5e-21 73.1 4.0 7.9e-05 22.5 0.0 6.1 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.1 KOO31079.1 - 8.1e-17 60.8 3.2 4.5e-08 33.0 0.0 4.4 1 1 4 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO31080.1 - 3.4e-24 84.2 3.3 6.9e-09 35.6 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO31080.1 - 1.5e-14 52.6 0.2 0.0013 18.8 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.25 KOO31080.1 - 6.5e-13 47.7 0.3 0.0016 18.1 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 KOO31080.1 - 5.4e-12 45.8 0.2 6.9e-06 26.4 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO31080.1 - 9.4e-12 45.1 2.2 5e-06 26.7 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Pentapeptide_4 PF13599.1 KOO31081.1 - 7.6e-06 25.6 0.0 0.22 11.3 0.0 3.6 3 1 0 3 3 3 2 Pentapeptide repeats (9 copies) Flexi_CP_N PF08358.5 KOO31081.1 - 0.082 12.6 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Carlavirus coat Pkinase PF00069.20 KOO31082.1 - 7.1e-37 126.9 0.0 9.4e-37 126.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31082.1 - 1.4e-35 122.6 0.0 1.7e-35 122.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO31082.1 - 0.033 13.9 1.4 0.099 12.3 1.0 1.9 1 1 0 1 1 1 0 Phosphotransferase enzyme family PP2C PF00481.16 KOO31083.1 - 1.4e-30 106.5 0.0 1.7e-30 106.2 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOO31083.1 - 2.4e-07 30.6 0.1 0.0013 18.5 0.0 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 KOO31083.1 - 2.6e-06 27.0 0.5 2.1e-05 24.0 0.3 2.2 1 1 0 1 1 1 1 Protein phosphatase 2C EF-hand_5 PF13202.1 KOO31084.1 - 3.5e-06 26.0 6.5 0.00015 20.9 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_1 PF00036.27 KOO31084.1 - 3.5e-05 22.8 5.6 0.0015 17.7 0.0 3.1 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO31084.1 - 0.002 17.6 0.9 0.1 12.1 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.1 KOO31084.1 - 0.062 13.4 4.1 0.11 12.7 0.0 2.9 3 0 0 3 3 3 0 EF-hand domain pair EF-hand_6 PF13405.1 KOO31084.1 - 0.066 13.1 3.6 0.39 10.7 0.0 2.9 3 0 0 3 3 3 0 EF-hand domain VCBS PF13517.1 KOO31084.1 - 0.15 12.4 1.5 6.1 7.2 0.1 2.7 2 0 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Dockerin_1 PF00404.13 KOO31084.1 - 0.65 9.8 7.4 3.9 7.3 1.4 2.7 2 0 0 2 2 2 0 Dockerin type I repeat FG-GAP PF01839.18 KOO31084.1 - 1 9.1 8.7 7.3 6.4 0.3 2.7 2 0 0 2 2 2 0 FG-GAP repeat Pkinase PF00069.20 KOO31086.1 - 3.8e-40 137.6 0.0 8.7e-40 136.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31086.1 - 1.1e-31 109.8 0.0 1.6e-31 109.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO31086.1 - 0.02 14.6 0.2 0.62 9.7 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Strumpellin PF10266.4 KOO31087.1 - 0 1013.9 3.7 5.7e-172 573.7 5.2 2.0 1 1 1 2 2 2 2 Hereditary spastic paraplegia protein strumpellin EF-hand_1 PF00036.27 KOO31089.1 - 1.3e-48 158.6 26.6 1.8e-05 23.6 0.0 11.4 11 0 0 11 11 11 10 EF hand EF-hand_7 PF13499.1 KOO31089.1 - 2.4e-46 155.7 10.0 3.2e-09 36.7 0.0 7.4 7 0 0 7 7 7 6 EF-hand domain pair EF-hand_6 PF13405.1 KOO31089.1 - 3.7e-46 150.8 18.5 0.00024 20.7 0.1 11.7 11 0 0 11 11 11 10 EF-hand domain EF-hand_8 PF13833.1 KOO31089.1 - 5.5e-35 118.7 17.4 4.7e-06 26.1 0.0 9.5 7 3 3 10 10 10 8 EF-hand domain pair EF-hand_5 PF13202.1 KOO31089.1 - 4e-31 104.9 33.5 0.00028 20.0 0.1 10.7 10 0 0 10 10 10 9 EF hand SPARC_Ca_bdg PF10591.4 KOO31089.1 - 2.2e-06 27.6 0.0 1.2 9.2 0.0 4.8 5 0 0 5 5 5 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO31089.1 - 4e-06 26.3 0.4 23 4.7 0.0 6.2 6 0 0 6 6 6 0 EF hand EF-hand_9 PF14658.1 KOO31089.1 - 0.026 14.4 0.1 6.4 6.7 0.0 4.3 5 1 0 6 6 6 0 EF-hand domain DUF4429 PF14472.1 KOO31089.1 - 0.039 14.2 0.0 0.1 12.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4429) TPR_11 PF13414.1 KOO31090.1 - 1.7e-19 69.1 30.9 1.5e-05 24.5 0.7 6.4 4 3 4 8 8 8 7 TPR repeat TPR_2 PF07719.12 KOO31090.1 - 8.2e-18 62.8 26.8 0.00016 21.2 0.2 8.8 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_16 PF13432.1 KOO31090.1 - 4.7e-17 62.1 43.3 5.4e-06 26.9 3.5 6.4 2 2 6 8 8 8 8 Tetratricopeptide repeat TPR_14 PF13428.1 KOO31090.1 - 1.2e-15 56.5 47.0 0.0075 16.8 0.8 9.7 3 3 6 9 9 9 8 Tetratricopeptide repeat TPR_12 PF13424.1 KOO31090.1 - 2.8e-14 52.8 35.6 1.2e-05 25.1 0.9 6.3 3 2 3 6 6 6 6 Tetratricopeptide repeat TPR_8 PF13181.1 KOO31090.1 - 1.2e-13 49.7 8.8 0.0017 18.0 0.0 7.5 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO31090.1 - 4.1e-13 48.3 16.2 0.00071 19.0 0.0 7.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_19 PF14559.1 KOO31090.1 - 2.7e-12 46.8 34.7 0.0016 18.7 0.8 7.1 4 3 3 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.1 KOO31090.1 - 5e-09 35.6 13.7 1.2 9.4 0.0 8.9 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO31090.1 - 1.1e-06 27.9 26.0 0.25 11.2 0.1 8.5 7 1 1 8 8 8 2 Tetratricopeptide repeat Apc3 PF12895.2 KOO31090.1 - 7.8e-06 25.9 21.0 0.016 15.3 0.5 5.7 3 2 3 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.9 KOO31090.1 - 0.00014 21.9 40.1 2 9.0 0.6 8.1 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_9 PF13371.1 KOO31090.1 - 0.00014 21.6 21.0 0.0069 16.2 0.2 5.0 4 2 0 4 4 4 3 Tetratricopeptide repeat TPR_21 PF09976.4 KOO31090.1 - 0.0025 17.7 3.4 0.0025 17.7 2.3 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_3 PF07720.7 KOO31090.1 - 0.005 16.5 1.6 2.7 7.8 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 KOO31090.1 - 0.14 12.6 0.2 0.14 12.6 0.1 7.0 8 0 0 8 8 8 0 Tetratricopeptide repeat Coatomer_WDAD PF04053.9 KOO31090.1 - 0.95 8.1 3.0 1.1 7.9 0.2 2.0 2 0 0 2 2 2 0 Coatomer WD associated region Myosin_head PF00063.16 KOO31091.1 - 3.3e-231 769.0 0.2 3.3e-231 769.0 0.1 2.0 2 0 0 2 2 2 1 Myosin head (motor domain) IQ PF00612.22 KOO31091.1 - 0.00014 21.1 51.7 0.0097 15.4 1.5 6.9 6 0 0 6 6 6 4 IQ calmodulin-binding motif Reo_sigmaC PF04582.7 KOO31091.1 - 0.11 11.7 2.0 0.3 10.2 1.4 1.7 1 0 0 1 1 1 0 Reovirus sigma C capsid protein AAA_22 PF13401.1 KOO31091.1 - 0.15 12.2 0.0 0.15 12.2 0.0 3.9 4 1 1 5 5 5 0 AAA domain Phage_int_SAM_1 PF02899.12 KOO31092.1 - 0.11 12.6 0.0 0.69 10.1 0.0 2.3 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain Glyco_hydro_76 PF03663.9 KOO31094.1 - 2.3e-23 83.2 4.1 3.2e-23 82.7 2.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Bromodomain PF00439.20 KOO31095.1 - 1.6e-25 88.8 0.0 5.7e-13 48.5 0.0 3.2 2 1 1 3 3 3 2 Bromodomain Cut12 PF11500.3 KOO31096.1 - 0.0059 16.3 1.8 0.0075 15.9 0.1 2.0 2 1 0 2 2 2 1 Spindle pole body formation-associated protein DUF1244 PF06844.6 KOO31096.1 - 0.46 10.3 4.7 0.36 10.6 1.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1244) DUF1795 PF08786.6 KOO31096.1 - 4.5 7.1 6.3 11 5.8 1.3 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF1795) LRR_6 PF13516.1 KOO31097.1 - 1.2e-17 61.9 23.2 0.14 12.3 0.0 12.9 13 0 0 13 13 13 6 Leucine Rich repeat LRR_4 PF12799.2 KOO31097.1 - 8.2e-10 38.0 7.4 0.15 11.7 0.1 6.3 6 0 0 6 6 6 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO31097.1 - 2e-08 33.1 1.2 1.6 9.0 0.0 8.3 11 0 0 11 11 11 1 Leucine Rich Repeat NACHT PF05729.7 KOO31097.1 - 6.5e-06 25.8 0.1 1.2e-05 25.0 0.1 1.4 1 0 0 1 1 1 1 NACHT domain LRR_8 PF13855.1 KOO31097.1 - 0.054 13.2 12.9 4.2 7.2 0.6 6.6 5 2 0 5 5 5 0 Leucine rich repeat LRR_7 PF13504.1 KOO31097.1 - 0.28 11.5 13.2 71 4.2 0.7 7.7 8 0 0 8 8 8 0 Leucine rich repeat AdoHcyase PF05221.12 KOO31098.1 - 5.8e-126 418.9 0.1 7.7e-126 418.5 0.1 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase MTHFR PF02219.12 KOO31098.1 - 1.2e-91 306.7 0.0 3.7e-91 305.1 0.0 1.8 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase AdoHcyase_NAD PF00670.16 KOO31098.1 - 2.2e-77 258.4 4.3 3.6e-77 257.7 3.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 KOO31098.1 - 3.2e-05 23.1 0.4 6e-05 22.2 0.3 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 KOO31098.1 - 0.0018 17.7 0.3 0.0031 16.9 0.2 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_7 PF13241.1 KOO31098.1 - 0.019 15.2 0.3 0.048 13.9 0.2 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding ELFV_dehydrog PF00208.16 KOO31098.1 - 0.025 14.1 0.2 0.07 12.6 0.1 1.8 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase TrkA_N PF02254.13 KOO31098.1 - 0.033 14.1 1.3 0.14 12.2 0.9 2.1 1 1 0 1 1 1 0 TrkA-N domain UPF0180 PF03698.8 KOO31098.1 - 0.15 11.9 0.8 0.37 10.6 0.6 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0180) FA_desaturase PF00487.19 KOO31100.1 - 3.6e-20 72.5 38.3 3.6e-20 72.5 26.6 2.1 2 1 1 3 3 3 1 Fatty acid desaturase Cyt-b5 PF00173.23 KOO31100.1 - 1.6e-05 24.6 0.2 4.7e-05 23.1 0.0 1.8 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Pkinase PF00069.20 KOO31101.1 - 1.7e-66 224.0 0.0 3.7e-66 222.9 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31101.1 - 2.5e-35 121.8 0.0 4e-35 121.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO31101.1 - 0.0003 19.8 0.0 0.00058 18.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO31101.1 - 0.0015 18.3 1.0 0.073 12.7 0.0 2.5 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 KOO31101.1 - 0.0054 15.8 0.0 0.0092 15.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Fez1 PF06818.10 KOO31101.1 - 0.018 15.0 3.9 0.04 13.9 2.7 1.5 1 0 0 1 1 1 0 Fez1 Ste50p-SAM PF09235.5 KOO31101.1 - 0.13 12.3 0.4 0.43 10.6 0.3 1.9 1 0 0 1 1 1 0 Ste50p, sterile alpha motif DUF3584 PF12128.3 KOO31101.1 - 0.47 7.7 6.3 0.66 7.2 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF2237 PF09996.4 KOO31103.1 - 0.13 11.7 0.0 0.33 10.4 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2237) Methyltransf_21 PF05050.7 KOO31105.1 - 1.1e-16 61.2 0.0 1.7e-16 60.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_18 PF12847.2 KOO31105.1 - 1.6e-07 31.8 0.0 4.1e-07 30.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO31105.1 - 0.0023 17.6 0.0 0.005 16.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain V_cholerae_RfbT PF05575.6 KOO31105.1 - 0.0086 15.1 0.1 0.037 13.0 0.0 1.8 1 1 0 1 1 1 1 Vibrio cholerae RfbT protein NOC3p PF07540.6 KOO31107.1 - 1.8e-23 82.5 0.1 4e-23 81.4 0.1 1.5 1 0 0 1 1 1 1 Nucleolar complex-associated protein DUF3306 PF11748.3 KOO31107.1 - 2.6 8.7 8.8 0.35 11.5 3.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) Metallophos PF00149.23 KOO31109.1 - 0.0018 17.7 0.0 0.0031 16.9 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Herpes_UL87 PF03043.9 KOO31110.1 - 0.013 13.8 1.8 0.053 11.9 1.2 2.1 1 1 0 1 1 1 0 Herpesvirus UL87 family AAA PF00004.24 KOO31111.1 - 2.6e-20 72.9 0.0 4.3e-20 72.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BCS1_N PF08740.6 KOO31111.1 - 1.2e-13 51.1 0.1 1.6e-13 50.6 0.1 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA_16 PF13191.1 KOO31111.1 - 4.9e-06 26.6 0.8 1e-05 25.6 0.5 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 KOO31111.1 - 3.3e-05 24.6 0.0 6.4e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOO31111.1 - 0.00041 20.0 0.0 0.001 18.7 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_33 PF13671.1 KOO31111.1 - 0.00058 19.7 0.0 0.0016 18.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 KOO31111.1 - 0.00091 18.6 0.3 0.0016 17.8 0.2 1.5 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 KOO31111.1 - 0.0019 18.1 0.1 0.0053 16.7 0.0 1.8 2 0 0 2 2 1 1 AAA domain RuvB_N PF05496.7 KOO31111.1 - 0.003 16.6 0.0 0.0045 16.0 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KOO31111.1 - 0.0039 17.3 0.0 0.011 15.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 KOO31111.1 - 0.0049 16.4 0.0 0.0062 16.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 KOO31111.1 - 0.0073 16.0 0.0 0.02 14.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 KOO31111.1 - 0.018 14.4 0.0 0.037 13.4 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.8 KOO31111.1 - 0.025 13.2 0.0 0.039 12.6 0.0 1.2 1 0 0 1 1 1 0 TIP49 C-terminus KaiC PF06745.8 KOO31111.1 - 0.051 12.6 0.0 0.083 11.9 0.0 1.2 1 0 0 1 1 1 0 KaiC AAA_18 PF13238.1 KOO31111.1 - 0.074 13.3 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 KOO31111.1 - 0.092 12.2 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.17 KOO31111.1 - 0.11 12.6 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 RNA helicase Zeta_toxin PF06414.7 KOO31111.1 - 0.16 11.0 0.0 0.25 10.4 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin IPT PF01745.11 KOO31111.1 - 0.16 11.1 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 Isopentenyl transferase AAA_24 PF13479.1 KOO31111.1 - 0.23 10.9 0.2 0.49 9.9 0.1 1.5 1 0 0 1 1 1 0 AAA domain TPT PF03151.11 KOO31112.1 - 0.048 13.3 20.2 0.048 13.3 7.0 2.4 1 1 1 2 2 2 0 Triose-phosphate Transporter family DNA_pol_B PF00136.16 KOO31115.1 - 9.8e-139 463.1 0.3 1.4e-138 462.6 0.2 1.1 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 KOO31115.1 - 1.1e-76 257.8 0.0 1.7e-76 257.2 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.1 KOO31115.1 - 1.3e-08 34.6 0.7 3.5e-08 33.3 0.5 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_A_exo1 PF01612.15 KOO31115.1 - 0.04 13.3 0.0 0.12 11.8 0.0 1.8 1 0 0 1 1 1 0 3'-5' exonuclease DNA_pol_B_2 PF03175.8 KOO31115.1 - 0.086 11.4 0.1 0.2 10.2 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral WD40 PF00400.27 KOO31116.1 - 5.7e-108 349.3 39.5 7.1e-12 44.7 0.1 10.8 11 1 1 12 12 12 10 WD domain, G-beta repeat PD40 PF07676.7 KOO31116.1 - 1.3e-20 72.6 6.3 0.55 9.9 0.0 8.4 8 0 0 8 8 8 8 WD40-like Beta Propeller Repeat BBS2_Mid PF14783.1 KOO31116.1 - 1.3e-12 47.4 4.1 0.0078 15.9 0.0 7.5 1 1 7 8 8 8 3 Ciliary BBSome complex subunit 2, middle region DUF3312 PF11768.3 KOO31116.1 - 3.2e-09 35.5 0.0 0.16 10.1 0.0 4.9 1 1 4 5 5 5 4 Protein of unknown function (DUF3312) Gmad1 PF10647.4 KOO31116.1 - 1e-06 28.3 3.8 0.99 8.7 0.1 5.8 2 2 3 6 6 6 2 Lipoprotein LpqB beta-propeller domain Dfp1_Him1_M PF08630.5 KOO31116.1 - 0.0001 22.0 9.5 4.5 7.0 0.0 6.4 6 2 0 7 7 7 2 Dfp1/Him1, central region DUF4467 PF14729.1 KOO31116.1 - 0.00056 20.1 0.0 28 5.1 0.0 4.8 3 2 2 5 5 5 0 Domain of unknown function with cystatin-like fold (DUF4467) CPSF_A PF03178.10 KOO31116.1 - 0.0013 17.9 0.8 0.78 8.7 0.0 3.2 1 1 0 2 2 2 2 CPSF A subunit region LigD_N PF13298.1 KOO31116.1 - 0.0085 16.1 2.9 7.1 6.7 0.0 4.8 3 1 3 6 6 6 1 DNA polymerase Ligase (LigD) bPH_4 PF06713.6 KOO31116.1 - 0.16 11.8 1.9 18 5.2 0.0 4.3 4 1 1 5 5 5 0 Bacterial PH domain DUF1476 PF07345.6 KOO31116.1 - 0.17 12.1 0.1 48 4.2 0.0 4.0 4 1 1 5 5 5 0 Domain of unknown function (DUF1476) DUF2621 PF11084.3 KOO31116.1 - 3.4 7.3 4.6 1.8e+02 1.7 0.0 4.9 5 2 2 7 7 7 0 Protein of unknown function (DUF2621) Aldo_ket_red PF00248.16 KOO31117.1 - 3e-24 85.3 0.0 5e-24 84.5 0.0 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family PKD_channel PF08016.7 KOO31118.1 - 1.1e-05 24.0 0.1 2.2e-05 23.0 0.1 1.4 1 0 0 1 1 1 1 Polycystin cation channel DUF1910 PF08928.5 KOO31118.1 - 0.031 14.2 0.8 0.074 13.0 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1910) Ion_trans PF00520.26 KOO31118.1 - 0.047 12.9 6.3 0.12 11.6 0.2 2.3 2 0 0 2 2 2 0 Ion transport protein Cauli_AT PF03233.8 KOO31118.1 - 0.12 12.0 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Aphid transmission protein HATPase_c PF02518.21 KOO31120.1 - 1.8e-06 27.6 0.0 3.9e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.19 KOO31120.1 - 0.029 14.3 0.0 0.074 13.0 0.0 1.8 1 1 0 1 1 1 0 Response regulator receiver domain PHD PF00628.24 KOO31121.1 - 4.7e-11 42.2 8.3 6.7e-11 41.7 5.8 1.2 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.1 KOO31121.1 - 0.00017 21.6 0.9 0.00028 20.9 0.6 1.4 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-PHD-like PF15446.1 KOO31121.1 - 0.00074 18.8 1.0 0.0012 18.1 0.7 1.3 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain PHD_2 PF13831.1 KOO31121.1 - 0.0055 15.9 2.1 0.0055 15.9 1.4 1.7 2 0 0 2 2 2 1 PHD-finger zf-Apc11 PF12861.2 KOO31121.1 - 0.18 11.6 2.1 0.27 11.0 1.5 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-HC5HC2H_2 PF13832.1 KOO31121.1 - 0.59 10.1 4.3 1.2 9.1 2.9 1.5 1 1 0 1 1 1 0 PHD-zinc-finger like domain Prok-RING_1 PF14446.1 KOO31121.1 - 1.5 8.5 8.4 1.1 9.0 3.7 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 DUF2577 PF10844.3 KOO31122.1 - 0.29 11.2 3.5 0.7 9.9 0.1 3.1 2 2 1 3 3 3 0 Protein of unknown function (DUF2577) AAA_12 PF13087.1 KOO31124.1 - 3.6e-31 108.1 0.0 1.4e-21 76.7 0.1 2.3 1 1 0 2 2 2 2 AAA domain AAA_11 PF13086.1 KOO31124.1 - 3.4e-11 43.1 0.0 9.7e-11 41.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.1 KOO31124.1 - 0.011 15.3 0.0 0.011 15.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain Abhydrolase_3 PF07859.8 KOO31126.1 - 1.4e-26 93.4 0.4 2.4e-26 92.6 0.3 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2424 PF10340.4 KOO31126.1 - 2.3e-05 23.2 0.0 0.041 12.5 0.0 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF2424) Abhydrolase_5 PF12695.2 KOO31126.1 - 2.3e-05 24.1 0.1 4.7e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family UCH PF00443.24 KOO31128.1 - 7.5e-25 87.5 0.0 2.1e-22 79.5 0.0 2.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOO31128.1 - 2.5e-05 23.8 0.0 0.027 13.9 0.0 2.9 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Nucleotid_trans PF03407.11 KOO31129.1 - 8.2e-32 110.7 0.0 1.2e-31 110.1 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase 2OG-FeII_Oxy_3 PF13640.1 KOO31130.1 - 8.8e-12 45.4 0.0 1.7e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO31130.1 - 4.1e-05 23.1 0.1 8e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PhyH PF05721.8 KOO31130.1 - 0.002 18.2 0.0 0.0033 17.4 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) MIT PF04212.13 KOO31130.1 - 0.034 14.0 0.1 0.061 13.2 0.1 1.4 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain RRM_1 PF00076.17 KOO31131.1 - 3.1e-17 61.9 0.0 5.1e-17 61.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO31131.1 - 2.8e-15 56.0 0.0 4.4e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO31131.1 - 1.9e-10 40.3 0.0 3.3e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CCDC155 PF14662.1 KOO31131.1 - 0.033 13.7 3.6 0.061 12.9 2.5 1.4 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 Laminin_II PF06009.7 KOO31131.1 - 0.058 13.1 0.6 0.11 12.2 0.4 1.3 1 0 0 1 1 1 0 Laminin Domain II WD40_alt PF14077.1 KOO31131.1 - 0.082 12.5 2.9 0.15 11.6 2.0 1.5 1 0 0 1 1 1 0 Alternative WD40 repeat motif Nup35_RRM_2 PF14605.1 KOO31131.1 - 0.093 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Sec3_C_2 PF15278.1 KOO31131.1 - 0.1 12.7 1.6 0.27 11.4 1.0 1.7 2 0 0 2 2 2 0 Sec3 exocyst complex subunit BLOC1_2 PF10046.4 KOO31131.1 - 0.16 12.1 2.0 0.3 11.2 1.4 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.7 KOO31131.1 - 0.16 12.2 0.5 0.3 11.3 0.3 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Spectrin PF00435.16 KOO31131.1 - 0.25 11.6 2.9 0.62 10.3 1.9 1.6 2 0 0 2 2 1 0 Spectrin repeat zf-CCCH PF00642.19 KOO31133.1 - 8.1e-06 25.3 4.3 1.2e-05 24.8 3.0 1.2 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 KOO31133.1 - 0.6 10.1 4.7 2.4 8.2 3.3 1.9 1 1 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type YrhK PF14145.1 KOO31134.1 - 2.6 7.7 17.0 3.1 7.5 0.1 3.8 3 1 0 3 3 3 0 YrhK-like protein Abhydrolase_6 PF12697.2 KOO31135.1 - 4e-23 82.4 4.7 5.3e-23 82.0 3.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO31135.1 - 2.1e-11 43.7 0.0 3.4e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO31135.1 - 0.049 13.1 0.0 1.1 8.7 0.0 2.2 1 1 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 KOO31135.1 - 0.083 12.7 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Putative lysophospholipase Dynamin_N PF00350.18 KOO31136.1 - 4.2e-13 49.4 0.0 1.8e-12 47.4 0.0 2.0 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 KOO31136.1 - 9.8e-05 22.2 0.0 0.011 15.6 0.0 3.2 3 0 0 3 3 3 1 50S ribosome-binding GTPase IIGP PF05049.8 KOO31136.1 - 0.0016 17.3 0.0 0.0054 15.6 0.0 1.7 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) AAA_29 PF13555.1 KOO31136.1 - 0.003 17.0 0.6 0.024 14.1 0.0 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain T2SE PF00437.15 KOO31136.1 - 0.0049 15.7 0.0 0.012 14.5 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein Miro PF08477.8 KOO31136.1 - 0.0061 17.0 0.1 0.014 15.8 0.1 1.6 1 0 0 1 1 1 1 Miro-like protein DUF258 PF03193.11 KOO31136.1 - 0.0067 15.6 0.0 0.017 14.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 KOO31136.1 - 0.0079 16.4 0.2 0.023 15.0 0.1 1.7 1 0 0 1 1 1 1 ABC transporter FtsK_SpoIIIE PF01580.13 KOO31136.1 - 0.0081 15.6 1.5 0.023 14.1 0.0 2.5 3 0 0 3 3 3 1 FtsK/SpoIIIE family AAA_23 PF13476.1 KOO31136.1 - 0.044 14.1 0.3 0.12 12.6 0.2 1.7 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 KOO31136.1 - 0.054 12.9 3.6 1.9 7.8 0.2 3.3 3 0 0 3 3 3 0 AAA-like domain AAA_28 PF13521.1 KOO31136.1 - 0.055 13.4 0.1 0.055 13.4 0.1 2.6 3 0 0 3 3 3 0 AAA domain Adeno_IVa2 PF02456.10 KOO31136.1 - 0.06 11.9 0.1 0.098 11.2 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_17 PF13207.1 KOO31136.1 - 0.11 13.3 0.0 0.48 11.2 0.0 2.2 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 KOO31136.1 - 0.14 11.5 1.1 1.1 8.6 0.0 2.7 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.13 KOO31136.1 - 0.15 11.0 0.0 0.26 10.2 0.0 1.3 1 0 0 1 1 1 0 Septin AIG1 PF04548.11 KOO31136.1 - 0.32 10.0 0.1 0.62 9.1 0.0 1.4 1 0 0 1 1 1 0 AIG1 family Med6 PF04934.9 KOO31137.1 - 8.7e-27 93.3 0.0 1.1e-26 93.0 0.0 1.0 1 0 0 1 1 1 1 MED6 mediator sub complex component Sulfotransfer_1 PF00685.22 KOO31138.1 - 0.00059 19.1 0.0 0.0011 18.3 0.0 1.4 1 1 0 1 1 1 1 Sulfotransferase domain LRR_8 PF13855.1 KOO31139.1 - 9.5e-20 70.1 31.8 2.4e-07 30.4 1.2 7.5 6 1 1 7 7 7 5 Leucine rich repeat LRR_4 PF12799.2 KOO31139.1 - 1.5e-18 66.0 33.4 1.9e-08 33.6 0.7 8.4 5 2 6 11 11 11 9 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO31139.1 - 5.6e-12 44.4 24.1 0.25 11.5 0.0 11.8 13 0 0 13 13 13 5 Leucine Rich repeat LRR_1 PF00560.28 KOO31139.1 - 1.4e-06 27.5 22.7 0.99 9.6 0.1 10.6 11 1 0 11 11 11 2 Leucine Rich Repeat Ras PF00071.17 KOO31139.1 - 0.017 14.4 0.0 0.04 13.2 0.0 1.6 1 0 0 1 1 1 0 Ras family G-alpha PF00503.15 KOO31139.1 - 0.1 11.2 0.0 0.22 10.1 0.0 1.4 1 0 0 1 1 1 0 G-protein alpha subunit Miro PF08477.8 KOO31139.1 - 0.11 12.9 0.0 0.36 11.3 0.0 1.9 1 0 0 1 1 1 0 Miro-like protein LRR_7 PF13504.1 KOO31139.1 - 0.93 9.9 24.1 12 6.5 0.0 10.1 13 0 0 13 13 13 0 Leucine rich repeat UvrD-helicase PF00580.16 KOO31139.1 - 1.1 8.5 4.3 0.59 9.3 0.0 2.4 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain DUF1402 PF07182.6 KOO31139.1 - 1.1 8.0 0.0 2.5 6.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1402) Dynamin_N PF00350.18 KOO31140.1 - 2.4e-14 53.5 0.0 1.1e-13 51.3 0.0 2.0 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 KOO31140.1 - 1.1e-06 28.6 0.0 0.0014 18.5 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase DUF258 PF03193.11 KOO31140.1 - 3.2e-05 23.1 0.0 0.00081 18.6 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 ABC_tran PF00005.22 KOO31140.1 - 5.6e-05 23.4 0.2 0.00037 20.7 0.0 2.5 2 2 1 3 3 2 1 ABC transporter FtsK_SpoIIIE PF01580.13 KOO31140.1 - 0.00043 19.8 0.7 0.0037 16.7 0.0 2.6 2 0 0 2 2 2 1 FtsK/SpoIIIE family T2SE PF00437.15 KOO31140.1 - 0.00098 18.1 2.7 0.0067 15.3 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_29 PF13555.1 KOO31140.1 - 0.0026 17.2 0.0 0.007 15.8 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain Miro PF08477.8 KOO31140.1 - 0.0036 17.7 0.0 0.012 16.0 0.0 1.9 2 0 0 2 2 1 1 Miro-like protein Zeta_toxin PF06414.7 KOO31140.1 - 0.0049 15.9 0.0 0.017 14.1 0.0 1.9 1 0 0 1 1 1 1 Zeta toxin AIG1 PF04548.11 KOO31140.1 - 0.0076 15.3 0.2 0.056 12.5 0.1 2.1 2 0 0 2 2 2 1 AIG1 family AAA_16 PF13191.1 KOO31140.1 - 0.011 15.6 0.0 0.011 15.6 0.0 4.0 4 0 0 4 4 4 0 AAA ATPase domain AAA_17 PF13207.1 KOO31140.1 - 0.012 16.4 0.0 0.073 13.8 0.0 2.5 2 0 0 2 2 1 0 AAA domain AAA_23 PF13476.1 KOO31140.1 - 0.016 15.5 1.3 0.037 14.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 KOO31140.1 - 0.019 14.6 0.0 0.037 13.7 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase Adeno_IVa2 PF02456.10 KOO31140.1 - 0.025 13.2 0.0 0.053 12.1 0.0 1.4 1 0 0 1 1 1 0 Adenovirus IVa2 protein GTP_EFTU PF00009.22 KOO31140.1 - 0.039 13.3 0.0 0.15 11.4 0.0 1.9 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 KOO31140.1 - 0.07 13.2 0.0 0.39 10.8 0.0 2.3 2 0 0 2 2 1 0 AAA domain IIGP PF05049.8 KOO31140.1 - 0.1 11.3 0.0 0.22 10.2 0.0 1.5 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) cobW PF02492.14 KOO31140.1 - 0.1 12.0 0.2 0.3 10.5 0.1 1.8 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.13 KOO31140.1 - 0.14 11.1 0.0 0.26 10.2 0.0 1.3 1 0 0 1 1 1 0 Septin FeoB_N PF02421.13 KOO31140.1 - 0.18 11.1 0.3 0.77 9.0 0.1 2.0 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_10 PF12846.2 KOO31140.1 - 0.19 11.1 3.4 0.08 12.3 0.3 1.8 2 0 0 2 2 2 0 AAA-like domain Herpes_Helicase PF02689.9 KOO31140.1 - 0.38 8.4 0.0 0.58 7.8 0.0 1.2 1 0 0 1 1 1 0 Helicase GST_C_2 PF13410.1 KOO31141.1 - 1.7e-06 27.8 0.0 3.5e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 KOO31141.1 - 1.1e-05 25.3 0.0 1.9e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Dpy-30 PF05186.8 KOO31141.1 - 0.053 13.0 0.0 0.091 12.2 0.0 1.4 1 0 0 1 1 1 0 Dpy-30 motif DUF647 PF04884.9 KOO31141.1 - 0.096 11.8 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Vitamin B6 photo-protection and homoeostasis SAM_1 PF00536.25 KOO31142.1 - 5.1e-06 26.5 0.1 1.2e-05 25.3 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 KOO31142.1 - 0.00012 21.8 0.1 0.00026 20.7 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) FKBP_C PF00254.23 KOO31143.1 - 3.8e-24 84.5 0.0 5.5e-24 84.0 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_7 PF13499.1 KOO31143.1 - 2.6e-08 33.8 0.0 4.1e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO31143.1 - 1.1e-05 24.3 1.6 0.037 13.3 0.7 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO31143.1 - 1.6e-05 24.3 0.8 0.2 11.6 0.3 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO31143.1 - 0.0018 17.8 0.5 2.1 8.0 0.3 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO31143.1 - 0.0024 17.1 1.5 0.081 12.3 0.7 2.6 2 0 0 2 2 2 1 EF hand SPARC_Ca_bdg PF10591.4 KOO31143.1 - 0.14 12.2 0.1 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Fasciclin PF02469.17 KOO31144.1 - 3.5e-34 117.5 0.0 5e-34 117.0 0.0 1.2 1 0 0 1 1 1 1 Fasciclin domain HlyIII PF03006.15 KOO31145.1 - 7e-25 87.7 20.6 9.1e-25 87.3 14.3 1.2 1 0 0 1 1 1 1 Haemolysin-III related YrhC PF14143.1 KOO31145.1 - 0.015 15.2 0.0 0.015 15.2 0.0 2.1 3 0 0 3 3 3 0 YrhC-like protein ABC_membrane_2 PF06472.10 KOO31145.1 - 0.11 11.5 0.0 0.31 10.1 0.0 1.7 1 1 0 1 1 1 0 ABC transporter transmembrane region 2 RseC_MucC PF04246.7 KOO31145.1 - 1.6 8.3 5.0 0.85 9.1 1.1 2.3 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC EF-hand_1 PF00036.27 KOO31147.1 - 1.9e-05 23.5 0.0 3e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.1 KOO31147.1 - 5.2e-05 22.4 0.0 8.3e-05 21.7 0.0 1.3 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO31147.1 - 0.00014 21.4 0.0 0.00021 20.8 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 KOO31147.1 - 0.0025 17.9 0.0 0.0061 16.6 0.0 1.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_9 PF14658.1 KOO31147.1 - 0.15 11.9 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain Ribosomal_S10 PF00338.17 KOO31148.1 - 2e-34 117.2 0.2 2.8e-34 116.8 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e LAP2alpha PF11560.3 KOO31149.1 - 0.11 11.6 1.4 0.15 11.2 1.0 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 2 alpha Cys_knot PF00007.17 KOO31149.1 - 0.31 11.1 5.6 3.9 7.6 0.4 3.0 3 0 0 3 3 3 0 Cystine-knot domain zf-DHHC PF01529.15 KOO31150.1 - 7.1e-21 74.3 0.0 1.4e-20 73.3 0.0 1.5 2 0 0 2 2 2 1 DHHC palmitoyltransferase Effector_1 PF04518.7 KOO31151.1 - 7.1 5.5 14.6 0.46 9.4 1.4 2.2 2 0 0 2 2 2 0 Effector from type III secretion system EF-hand_1 PF00036.27 KOO31155.1 - 7e-26 87.5 14.8 6e-05 22.0 0.1 7.4 6 1 1 7 7 7 6 EF hand EF-hand_6 PF13405.1 KOO31155.1 - 1.7e-21 74.1 12.9 0.013 15.3 0.1 7.4 6 1 1 7 7 7 6 EF-hand domain EF-hand_7 PF13499.1 KOO31155.1 - 7e-21 74.1 14.8 8.3e-08 32.2 0.3 6.2 1 1 4 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.1 KOO31155.1 - 1.4e-20 71.6 10.5 0.00029 20.0 0.1 7.4 7 0 0 7 7 7 5 EF hand EF-hand_8 PF13833.1 KOO31155.1 - 2.1e-12 46.4 13.8 4.1e-05 23.1 0.3 6.8 5 2 2 7 7 7 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO31155.1 - 7e-06 26.0 0.2 1.5 8.9 0.0 4.4 3 2 0 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO31155.1 - 1.7e-05 24.4 3.8 2.9 7.6 0.0 4.8 3 1 2 5 5 5 2 Cytoskeletal-regulatory complex EF hand DUF1880 PF08976.6 KOO31155.1 - 0.14 12.3 0.0 24 5.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1880) MULE PF10551.4 KOO31157.1 - 8.8e-05 22.5 0.0 0.00029 20.9 0.0 1.9 2 0 0 2 2 2 1 MULE transposase domain DDE_Tnp_IS66 PF03050.9 KOO31157.1 - 0.007 15.6 0.2 0.015 14.4 0.0 1.6 2 0 0 2 2 2 1 Transposase IS66 family Nop14 PF04147.7 KOO31158.1 - 0.036 12.0 9.4 0.046 11.6 6.5 1.2 1 0 0 1 1 1 0 Nop14-like family DUF4611 PF15387.1 KOO31158.1 - 2.2 8.4 10.3 5.9 7.1 7.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Paf1 PF03985.8 KOO31158.1 - 3.7 6.1 8.4 5.6 5.5 5.8 1.2 1 0 0 1 1 1 0 Paf1 DUF2237 PF09996.4 KOO31159.1 - 0.11 11.9 4.4 0.64 9.5 3.0 2.0 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2237) PDZ PF00595.19 KOO31161.1 - 5.4e-23 80.9 0.1 8e-06 25.9 0.0 3.6 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO31161.1 - 6.8e-12 45.1 0.5 0.002 17.9 0.0 3.5 3 0 0 3 3 3 3 PDZ domain EF-hand_1 PF00036.27 KOO31161.1 - 2e-09 36.0 0.1 0.00035 19.6 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO31161.1 - 4.3e-09 35.8 0.1 8e-09 34.9 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair cNMP_binding PF00027.24 KOO31161.1 - 6.3e-09 35.5 0.0 1.8e-07 30.8 0.0 3.0 2 1 0 2 2 2 1 Cyclic nucleotide-binding domain EF-hand_6 PF13405.1 KOO31161.1 - 1.5e-08 33.7 0.1 0.00068 19.3 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO31161.1 - 2.4e-06 26.6 0.2 0.00044 19.4 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO31161.1 - 2.6e-06 27.4 0.2 4.3e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair Phage_holin_2 PF04550.7 KOO31161.1 - 5.2 7.2 7.5 1.2 9.2 0.1 3.0 3 0 0 3 3 3 0 Phage holin family 2 GLE1 PF07817.8 KOO31162.1 - 2.3e-10 39.8 0.0 2.3e-10 39.8 0.0 2.2 3 0 0 3 3 3 1 GLE1-like protein CDC37_N PF03234.9 KOO31162.1 - 9.3e-05 22.8 0.0 9.3e-05 22.8 0.0 2.5 2 0 0 2 2 2 1 Cdc37 N terminal kinase binding DUF4335 PF14233.1 KOO31162.1 - 0.085 12.3 0.5 0.2 11.0 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4335) Spore_coat_CotO PF14153.1 KOO31162.1 - 1 8.7 17.4 0.27 10.6 6.4 2.4 2 0 0 2 2 2 0 Spore coat protein CotO DUF4207 PF13904.1 KOO31162.1 - 4.6 6.5 21.7 5.8 6.2 10.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4207) Phage_base_V PF04717.7 KOO31163.1 - 0.076 12.9 0.7 0.34 10.8 0.0 2.2 2 0 0 2 2 2 0 Phage-related baseplate assembly protein Parathyroid PF01279.12 KOO31163.1 - 0.11 13.1 0.0 0.2 12.3 0.0 1.3 1 0 0 1 1 1 0 Parathyroid hormone family DUF1281 PF06924.6 KOO31164.1 - 0.055 12.8 0.1 0.19 11.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1281) Stc1 PF12898.2 KOO31164.1 - 6.2 6.9 9.7 4.7 7.3 0.3 3.0 3 0 0 3 3 3 0 Stc1 domain AP2 PF00847.15 KOO31165.1 - 8.2e-11 41.8 4.5 0.00012 22.1 0.1 5.4 6 2 1 7 7 7 3 AP2 domain zf-CXXC PF02008.15 KOO31165.1 - 6.8e-07 28.9 1.6 1.6e-06 27.8 1.1 1.5 1 0 0 1 1 1 1 CXXC zinc finger domain NAD_binding_10 PF13460.1 KOO31167.1 - 2.1e-24 86.5 0.2 4.1e-24 85.5 0.1 1.5 1 1 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 KOO31167.1 - 5.3e-15 55.4 0.0 1e-14 54.5 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 KOO31167.1 - 4.3e-09 35.9 0.3 6.7e-09 35.3 0.1 1.4 2 0 0 2 2 2 1 NmrA-like family 3Beta_HSD PF01073.14 KOO31167.1 - 5.3e-08 31.9 0.0 9.1e-08 31.1 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 KOO31167.1 - 0.00029 19.8 0.6 0.0014 17.6 0.4 2.0 1 1 0 1 1 1 1 RmlD substrate binding domain Saccharop_dh PF03435.13 KOO31167.1 - 0.00087 18.3 0.1 0.0013 17.7 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NAD_binding_4 PF07993.7 KOO31167.1 - 0.0034 16.3 0.7 0.96 8.3 0.1 2.7 2 1 0 2 2 2 2 Male sterility protein Semialdhyde_dh PF01118.19 KOO31167.1 - 0.0051 17.1 0.2 0.01 16.1 0.1 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_7 PF13241.1 KOO31167.1 - 0.12 12.6 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding HRDC PF00570.18 KOO31167.1 - 0.2 11.3 0.4 5.6 6.7 0.0 2.4 2 0 0 2 2 2 0 HRDC domain Glyco_transf_8 PF01501.15 KOO31168.1 - 3.7e-09 36.2 0.0 1.1e-08 34.7 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferase family 8 DUF447 PF04289.7 KOO31169.1 - 0.067 12.7 3.6 0.12 11.9 2.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF447) PALP PF00291.20 KOO31170.1 - 2.8e-53 181.1 0.0 4.3e-53 180.5 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme RabGAP-TBC PF00566.13 KOO31171.1 - 4.9e-38 130.7 0.1 7.5e-38 130.1 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain IncA PF04156.9 KOO31172.1 - 0.61 9.6 16.0 0.84 9.2 3.6 2.5 2 0 0 2 2 2 0 IncA protein APG6 PF04111.7 KOO31172.1 - 1.5 7.7 16.4 2.1 7.2 4.5 2.1 2 0 0 2 2 2 0 Autophagy protein Apg6 V_ATPase_I PF01496.14 KOO31172.1 - 2.3 5.9 5.8 0.78 7.5 0.9 1.9 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Spc7 PF08317.6 KOO31172.1 - 4.3 5.9 8.2 1.6 7.3 0.2 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF972 PF06156.8 KOO31172.1 - 7.7 6.9 8.7 14 6.0 1.8 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF972) UPF0370 PF13980.1 KOO31174.1 - 0.057 13.2 0.1 0.17 11.7 0.1 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) TPR_11 PF13414.1 KOO31175.1 - 2.1e-07 30.4 1.4 0.00051 19.6 0.1 1.9 1 1 1 2 2 2 2 TPR repeat TPR_16 PF13432.1 KOO31175.1 - 0.0003 21.3 3.2 0.0013 19.3 0.6 1.9 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO31175.1 - 0.011 15.5 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_17 PF13431.1 KOO31175.1 - 0.033 14.3 0.0 6.5 7.2 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO31175.1 - 0.05 14.2 1.2 0.068 13.8 0.2 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO31175.1 - 0.081 12.7 0.3 0.17 11.7 0.2 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.1 KOO31175.1 - 0.09 13.1 0.3 0.27 11.6 0.1 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Sel1 PF08238.7 KOO31176.1 - 3.8e-19 68.6 11.7 9.6e-07 29.2 0.2 4.5 4 0 0 4 4 4 3 Sel1 repeat U-box PF04564.10 KOO31176.1 - 7.3e-19 67.5 0.0 1.1e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO31176.1 - 3.4e-05 23.2 0.0 8.8e-05 21.9 0.0 1.6 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 KOO31176.1 - 0.076 12.7 0.0 0.41 10.3 0.0 2.1 2 0 0 2 2 2 0 RING-type zinc-finger RR_TM4-6 PF06459.7 KOO31176.1 - 3.4 7.4 9.5 4.8 6.9 6.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Sel1 PF08238.7 KOO31177.1 - 2.1e-56 187.1 71.6 9.1e-07 29.3 0.8 10.4 10 0 0 10 10 10 10 Sel1 repeat U-box PF04564.10 KOO31177.1 - 2.1e-16 59.6 0.0 3e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO31177.1 - 0.00015 21.2 0.0 0.00034 20.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit ParD PF09386.5 KOO31177.1 - 0.18 11.9 3.6 15 5.7 0.0 3.8 3 1 1 4 4 4 0 Antitoxin ParD PRP21_like_P PF12230.3 KOO31177.1 - 0.27 10.6 4.3 0.41 10.1 3.0 1.1 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein RR_TM4-6 PF06459.7 KOO31177.1 - 6 6.6 8.2 9.3 6.0 5.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Rtf2 PF04641.7 KOO31177.1 - 8.4 5.5 14.1 1.5e+02 1.3 0.0 2.0 1 1 1 2 2 2 0 Rtf2 RING-finger Pkinase PF00069.20 KOO31180.1 - 6.2e-52 176.3 0.0 8.6e-52 175.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31180.1 - 6.8e-43 146.5 0.0 8.9e-43 146.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO31180.1 - 0.066 12.1 0.0 0.1 11.5 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.9 KOO31180.1 - 0.084 11.9 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO31180.1 - 0.21 11.2 0.5 0.42 10.2 0.1 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family CDC27 PF09507.5 KOO31181.1 - 4.6e-31 108.5 22.7 9.9e-31 107.4 15.8 1.8 1 1 0 1 1 1 1 DNA polymerase subunit Cdc27 TauD PF02668.11 KOO31181.1 - 1.6e-19 70.5 0.0 4.2e-19 69.2 0.0 1.6 2 0 0 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family UIM PF02809.15 KOO31182.1 - 1.9 8.2 4.3 1.3 8.7 0.3 2.4 2 0 0 2 2 2 0 Ubiquitin interaction motif DUF3043 PF11241.3 KOO31182.1 - 4.4 6.8 6.0 6 6.4 4.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) ADPrib_exo_Tox PF03496.9 KOO31183.1 - 1e-06 28.1 0.0 0.0031 16.7 0.0 2.5 2 1 0 2 2 2 2 ADP-ribosyltransferase exoenzyme ART PF01129.13 KOO31183.1 - 0.095 11.7 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase WLM PF08325.5 KOO31184.1 - 6.1e-34 117.5 0.0 2.7e-33 115.4 0.0 1.8 1 1 1 2 2 2 1 WLM domain DUF45 PF01863.12 KOO31184.1 - 0.016 14.9 0.8 0.03 14.1 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF45 YukD PF08817.5 KOO31184.1 - 0.046 14.2 0.1 0.14 12.7 0.0 1.8 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD Peptidase_MA_2 PF13485.1 KOO31184.1 - 0.38 10.8 2.9 0.78 9.7 2.0 1.7 1 1 0 1 1 1 0 Peptidase MA superfamily BT1 PF03092.11 KOO31185.1 - 5.7e-62 209.8 6.4 1.3e-61 208.6 4.4 1.5 1 1 0 1 1 1 1 BT1 family Ank_2 PF12796.2 KOO31186.1 - 1.5e-37 127.7 16.5 1e-12 48.2 1.5 3.3 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 KOO31186.1 - 1.3e-25 87.9 9.4 2.3e-06 27.1 0.0 6.1 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.1 KOO31186.1 - 1.2e-22 79.3 4.4 1.7e-07 31.2 0.0 4.7 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO31186.1 - 7.4e-19 67.7 0.5 5.8e-05 23.4 0.1 4.6 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO31186.1 - 4.6e-15 54.2 3.4 0.026 14.7 0.0 5.9 5 0 0 5 5 5 5 Ankyrin repeat DisA_N PF02457.11 KOO31186.1 - 0.0002 20.4 0.0 0.00037 19.6 0.0 1.4 1 0 0 1 1 1 1 DisA bacterial checkpoint controller nucleotide-binding Glucosaminidase PF01832.15 KOO31186.1 - 0.05 13.7 0.3 0.086 12.9 0.2 1.4 1 0 0 1 1 1 0 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase DUF4164 PF13747.1 KOO31186.1 - 3.9 7.6 10.9 0.4 10.8 1.9 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4164) Apyrase PF06079.6 KOO31187.1 - 3e-57 194.0 0.0 4.8e-57 193.3 0.0 1.3 1 0 0 1 1 1 1 Apyrase PNRC PF15365.1 KOO31187.1 - 0.23 11.4 0.2 0.23 11.4 0.1 1.6 2 0 0 2 2 2 0 Proline-rich nuclear receptor coactivator 4HBT_2 PF13279.1 KOO31189.1 - 1.6e-12 47.9 0.0 2.1e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.17 KOO31189.1 - 1.7e-08 34.4 0.2 6.5e-08 32.5 0.0 2.0 2 0 0 2 2 2 1 Thioesterase superfamily Acyl-ACP_TE PF01643.12 KOO31189.1 - 0.069 12.0 0.0 0.1 11.4 0.0 1.2 1 0 0 1 1 1 0 Acyl-ACP thioesterase cNMP_binding PF00027.24 KOO31190.1 - 5.8e-23 80.5 0.0 3.9e-11 42.6 0.0 3.2 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain Yae1_N PF09811.4 KOO31190.1 - 0.19 11.3 5.7 0.44 10.1 3.9 1.6 1 0 0 1 1 1 0 Essential protein Yae1, N terminal DUF2360 PF10152.4 KOO31190.1 - 0.84 9.9 5.5 4.7 7.4 0.3 2.3 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) FAM92 PF06730.6 KOO31191.1 - 0.0072 15.6 2.0 0.012 14.9 1.4 1.3 1 0 0 1 1 1 1 FAM92 protein DUF2564 PF10819.3 KOO31191.1 - 0.12 12.5 5.9 4.6 7.4 0.2 3.1 2 2 0 2 2 2 0 Protein of unknown function (DUF2564) PX PF00787.19 KOO31192.1 - 0.035 13.8 0.0 0.074 12.8 0.0 1.4 1 0 0 1 1 1 0 PX domain Serglycin PF04360.7 KOO31192.1 - 1 9.0 11.0 2.1 8.0 7.6 1.4 1 0 0 1 1 1 0 Serglycin SET PF00856.23 KOO31193.1 - 7.2e-21 75.1 1.2 4.5e-20 72.5 0.2 2.4 2 1 0 2 2 2 1 SET domain Pre-SET PF05033.11 KOO31193.1 - 3.1e-06 27.3 0.0 3.1e-06 27.3 0.0 3.1 2 1 0 2 2 2 1 Pre-SET motif PHD PF00628.24 KOO31193.1 - 0.12 12.0 27.6 1.7 8.4 8.6 3.6 2 1 0 2 2 2 0 PHD-finger DUF393 PF04134.7 KOO31194.1 - 4.6e-18 66.3 0.0 7.8e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF393 WW PF00397.21 KOO31196.1 - 6.7e-06 25.8 0.2 1.7e-05 24.5 0.2 1.7 1 0 0 1 1 1 1 WW domain DUF1863 PF08937.6 KOO31196.1 - 0.17 11.9 3.4 4.6 7.3 0.0 3.7 4 1 0 4 4 4 0 MTH538 TIR-like domain (DUF1863) IQ PF00612.22 KOO31196.1 - 4.5 7.1 6.4 0.94 9.3 0.1 3.0 3 0 0 3 3 3 0 IQ calmodulin-binding motif MatE PF01554.13 KOO31198.1 - 7.3e-49 165.4 34.0 5.5e-25 87.8 10.6 2.1 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.1 KOO31198.1 - 6.2e-07 29.3 2.2 6.2e-07 29.3 1.5 4.7 3 2 0 4 4 4 2 Polysaccharide biosynthesis C-terminal domain NUP PF06516.6 KOO31199.1 - 2.4e-34 118.6 0.0 2.8e-34 118.3 0.0 1.1 1 0 0 1 1 1 1 Purine nucleoside permease (NUP) TPR_11 PF13414.1 KOO31200.1 - 4.8e-08 32.5 2.9 4.8e-08 32.5 2.0 4.5 3 1 1 4 4 4 2 TPR repeat TPR_2 PF07719.12 KOO31200.1 - 7.2e-07 28.6 22.9 0.089 12.7 0.2 6.5 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO31200.1 - 0.00038 19.9 11.7 0.11 12.1 0.1 5.1 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO31200.1 - 0.00084 18.9 7.0 0.077 12.8 0.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat Agenet PF05641.7 KOO31201.1 - 7.2e-07 29.2 0.9 1.8e-06 27.9 0.1 2.1 2 0 0 2 2 2 1 Agenet domain MBD PF01429.14 KOO31201.1 - 0.00011 21.6 0.1 0.00034 20.0 0.0 1.7 1 0 0 1 1 1 1 Methyl-CpG binding domain Ribosomal_60s PF00428.14 KOO31203.1 - 0.64 10.4 5.3 0.8 10.1 3.7 1.1 1 0 0 1 1 1 0 60s Acidic ribosomal protein Ank_2 PF12796.2 KOO31205.1 - 3.1e-16 59.4 0.0 6.9e-07 29.5 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO31205.1 - 6.8e-15 55.1 0.1 1.1e-08 35.3 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO31205.1 - 7.4e-14 51.4 1.1 8.9e-05 22.6 0.0 4.3 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO31205.1 - 7.9e-14 50.6 1.8 1.9e-06 27.3 0.1 3.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.1 KOO31205.1 - 2.2e-09 36.6 0.2 0.0042 17.1 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat AA_permease PF00324.16 KOO31206.1 - 1.4e-23 83.0 28.5 3.2e-22 78.5 19.8 2.0 1 1 0 1 1 1 1 Amino acid permease zf-RING_2 PF13639.1 KOO31209.1 - 1.2e-06 28.2 4.0 1.2e-06 28.2 2.7 1.8 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 KOO31209.1 - 6.3e-06 25.8 3.6 1.5e-05 24.5 2.5 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 KOO31209.1 - 0.00061 19.4 1.6 0.0015 18.1 1.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO31209.1 - 0.00082 19.3 4.1 0.0021 18.0 2.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO31209.1 - 0.0034 17.0 7.8 0.015 14.9 5.4 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 KOO31209.1 - 0.077 12.7 0.5 0.16 11.7 0.3 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-rbx1 PF12678.2 KOO31209.1 - 0.13 12.3 1.1 0.29 11.2 0.8 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger MUG113 PF13455.1 KOO31209.1 - 1.5 9.3 4.6 0.65 10.4 0.9 2.0 2 0 0 2 2 2 0 Meiotically up-regulated gene 113 KxDL PF10241.4 KOO31209.1 - 5.3 7.0 6.4 5.6 6.9 1.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein VCBS PF13517.1 KOO31212.1 - 1.1e-85 281.9 113.9 3.1e-13 49.8 4.9 9.5 1 1 8 9 9 9 9 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO31212.1 - 3.8e-50 166.4 92.1 1.2e-05 24.8 0.6 10.5 10 0 0 10 10 10 10 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO31212.1 - 5.9e-18 64.9 40.9 0.19 11.1 0.1 10.2 2 2 8 10 10 10 10 Insecticide toxin TcdB middle/N-terminal region GCC2_GCC3 PF07699.8 KOO31212.1 - 4e-15 55.1 89.1 3.7e-07 29.6 0.9 10.6 6 1 6 12 12 12 5 GCC2 and GCC3 NCD3G PF07562.9 KOO31212.1 - 0.00029 20.4 5.4 0.00029 20.4 3.7 8.4 6 2 3 9 9 9 2 Nine Cysteines Domain of family 3 GPCR EF-hand_5 PF13202.1 KOO31212.1 - 8.5 5.9 61.7 8.7 5.8 0.6 10.4 10 0 0 10 10 10 0 EF hand BBS2_Mid PF14783.1 KOO31212.1 - 9.2 6.0 9.0 1.3e+02 2.4 0.0 6.3 9 0 0 9 9 9 0 Ciliary BBSome complex subunit 2, middle region Pkinase PF00069.20 KOO31213.1 - 2.3e-48 164.6 0.0 3.3e-48 164.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31213.1 - 1e-39 136.1 0.0 1.7e-39 135.4 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO31213.1 - 1.2e-05 24.4 0.0 1.8e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO31213.1 - 0.02 14.6 0.4 0.13 12.0 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Ank_2 PF12796.2 KOO31214.1 - 1.7e-06 28.2 0.8 3.8e-06 27.1 0.5 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO31214.1 - 6.2e-06 25.9 0.5 0.002 18.1 0.1 3.5 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.1 KOO31214.1 - 0.0001 22.4 0.5 0.0011 19.0 0.1 2.8 2 1 2 4 4 4 1 Ankyrin repeats (many copies) Ank PF00023.25 KOO31214.1 - 0.0002 20.9 1.8 0.00064 19.4 0.3 2.3 2 1 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.1 KOO31214.1 - 0.00037 20.9 0.8 0.0051 17.3 0.1 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) EF-hand_7 PF13499.1 KOO31215.1 - 2.1e-15 56.6 5.7 0.00012 22.1 0.0 5.7 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.27 KOO31215.1 - 2.9e-14 51.1 9.7 0.0035 16.5 0.0 7.2 7 2 1 8 8 8 4 EF hand EF-hand_6 PF13405.1 KOO31215.1 - 7.6e-14 50.2 13.6 0.0067 16.2 0.0 7.8 7 2 1 8 8 8 3 EF-hand domain EF-hand_8 PF13833.1 KOO31215.1 - 7.7e-12 44.6 1.6 0.0013 18.3 0.0 4.5 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO31215.1 - 2.9e-11 42.1 12.2 0.0011 18.1 0.0 5.7 6 0 0 6 6 6 3 EF hand EF-hand_4 PF12763.2 KOO31215.1 - 2.2 8.0 5.3 5.2 6.8 0.0 3.5 3 2 1 4 4 4 0 Cytoskeletal-regulatory complex EF hand AAA PF00004.24 KOO31216.1 - 1.1e-17 64.4 0.0 2.7e-17 63.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 KOO31216.1 - 1.9e-07 31.8 0.3 3.7e-06 27.7 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 KOO31216.1 - 1.7e-06 27.7 0.0 3.8e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activ_2 PF14532.1 KOO31216.1 - 0.00034 20.6 0.0 0.0026 17.8 0.0 2.4 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_16 PF13191.1 KOO31216.1 - 0.00058 19.9 0.2 0.002 18.1 0.0 2.0 2 1 0 2 2 2 1 AAA ATPase domain AAA_19 PF13245.1 KOO31216.1 - 0.00063 19.4 0.0 0.002 17.8 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 KOO31216.1 - 0.00086 19.4 0.0 0.0027 17.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOO31216.1 - 0.001 19.3 0.1 0.012 15.8 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.1 KOO31216.1 - 0.0019 17.6 0.0 0.026 13.9 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.1 KOO31216.1 - 0.0024 17.7 0.0 0.0056 16.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 KOO31216.1 - 0.0052 16.7 0.0 0.017 15.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 KOO31216.1 - 0.058 12.9 0.0 2.9 7.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 KOO31216.1 - 0.071 13.2 0.0 0.19 11.9 0.0 1.8 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.12 KOO31216.1 - 0.079 12.3 0.1 0.17 11.2 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_11 PF13086.1 KOO31216.1 - 0.085 12.4 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 KOO31216.1 - 0.14 11.5 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Ras PF00071.17 KOO31217.1 - 1.7e-55 186.8 0.0 2e-55 186.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO31217.1 - 4.9e-16 59.3 0.0 7.9e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO31217.1 - 3.9e-12 45.7 0.0 4.4e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 KOO31217.1 - 1.9e-06 27.7 0.0 2.7e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 KOO31217.1 - 1.1e-05 24.7 0.0 1.5e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.1 KOO31217.1 - 0.00041 20.5 0.0 0.00061 19.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 KOO31217.1 - 0.00052 19.2 0.0 0.00077 18.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_5 PF07728.9 KOO31217.1 - 0.002 17.8 0.0 0.0053 16.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) GTP_EFTU PF00009.22 KOO31217.1 - 0.003 17.0 0.0 0.08 12.3 0.0 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.1 KOO31217.1 - 0.0043 16.6 0.0 0.007 15.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.10 KOO31217.1 - 0.0059 16.3 0.1 0.014 15.1 0.0 1.6 2 0 0 2 2 2 1 NTPase Arch_ATPase PF01637.13 KOO31217.1 - 0.0068 16.1 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase PduV-EutP PF10662.4 KOO31217.1 - 0.0094 15.4 0.1 0.072 12.5 0.0 2.0 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Septin PF00735.13 KOO31217.1 - 0.012 14.6 0.2 0.021 13.8 0.0 1.5 2 0 0 2 2 2 0 Septin MobB PF03205.9 KOO31217.1 - 0.012 15.3 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 KOO31217.1 - 0.012 15.5 0.1 0.038 13.9 0.0 1.7 2 1 0 2 2 2 0 AAA ATPase domain AAA_10 PF12846.2 KOO31217.1 - 0.015 14.7 0.1 0.031 13.7 0.1 1.4 1 1 0 1 1 1 0 AAA-like domain SRPRB PF09439.5 KOO31217.1 - 0.02 14.1 0.0 0.031 13.5 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit cobW PF02492.14 KOO31217.1 - 0.029 13.8 0.0 0.06 12.7 0.0 1.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.1 KOO31217.1 - 0.074 12.9 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 KOO31217.1 - 0.078 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA PF00004.24 KOO31217.1 - 0.11 12.6 0.0 0.28 11.4 0.0 1.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Proteasome PF00227.21 KOO31217.1 - 0.13 11.5 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Proteasome subunit TPT PF03151.11 KOO31218.1 - 5e-11 42.4 9.7 5e-11 42.4 6.7 2.6 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 KOO31218.1 - 0.0024 17.9 11.0 0.0024 17.9 7.6 3.1 3 1 1 4 4 4 2 EamA-like transporter family UAA PF08449.6 KOO31218.1 - 0.0061 15.5 22.1 0.017 14.0 15.4 2.0 1 1 0 1 1 1 1 UAA transporter family DUF3382 PF11862.3 KOO31218.1 - 0.028 14.3 0.7 0.028 14.3 0.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF3382) EF-hand_1 PF00036.27 KOO31219.1 - 2.8e-06 26.2 0.3 8e-06 24.7 0.2 1.9 1 0 0 1 1 1 1 EF hand Ax_dynein_light PF10211.4 KOO31219.1 - 1.6e-05 24.8 14.8 5.8e-05 23.0 9.9 2.4 1 1 0 1 1 1 1 Axonemal dynein light chain EF-hand_6 PF13405.1 KOO31219.1 - 0.00022 20.8 0.0 0.00089 18.9 0.0 2.1 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.1 KOO31219.1 - 0.001 18.2 0.3 0.0041 16.4 0.1 2.2 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO31219.1 - 0.002 18.1 0.0 0.0079 16.3 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain pair Atg14 PF10186.4 KOO31219.1 - 0.0074 15.2 11.8 0.014 14.3 8.2 1.4 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 DUF3989 PF13150.1 KOO31219.1 - 0.025 14.0 0.2 0.25 10.8 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) FlaC_arch PF05377.6 KOO31219.1 - 0.31 10.9 2.2 0.93 9.4 0.2 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Cep57_MT_bd PF06657.8 KOO31219.1 - 1.1 9.2 17.0 0.53 10.2 1.3 3.7 4 0 0 4 4 4 0 Centrosome microtubule-binding domain of Cep57 Baculo_PEP_C PF04513.7 KOO31219.1 - 1.4 8.7 5.5 1.7 8.4 1.7 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus SlyX PF04102.7 KOO31219.1 - 2.2 8.6 7.5 6.5 7.2 0.9 3.1 2 0 0 2 2 2 0 SlyX AAA_23 PF13476.1 KOO31219.1 - 3 8.0 7.0 6.9 6.9 4.8 1.6 1 0 0 1 1 1 0 AAA domain TBPIP PF07106.8 KOO31219.1 - 8.1 5.9 14.9 1.1 8.8 4.2 2.6 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) FKBP_C PF00254.23 KOO31220.1 - 1.6e-32 111.3 0.0 2e-32 111.0 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Nuc_sug_transp PF04142.10 KOO31221.1 - 0.0016 17.6 3.5 0.0058 15.7 0.1 2.2 2 0 0 2 2 2 1 Nucleotide-sugar transporter EamA PF00892.15 KOO31221.1 - 0.01 15.8 15.7 0.33 11.0 0.3 3.3 2 1 0 3 3 3 0 EamA-like transporter family Coatomer_b_Cpla PF14806.1 KOO31221.1 - 0.081 12.6 0.1 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Coatomer beta subunit appendage platform TPT PF03151.11 KOO31221.1 - 5.9 6.5 17.0 0.084 12.5 2.6 3.6 4 1 1 5 5 5 0 Triose-phosphate Transporter family DUF1079 PF06435.6 KOO31223.1 - 8.8e-05 22.3 4.0 3.6 7.6 0.0 5.3 5 2 0 5 5 5 3 Repeat of unknown function (DUF1079) Dynein_heavy PF03028.10 KOO31224.1 - 4.9e-129 431.4 0.0 1.7e-57 194.9 0.0 5.0 4 2 0 4 4 4 3 Dynein heavy chain and region D6 of dynein motor AAA_8 PF12780.2 KOO31224.1 - 6.3e-78 261.4 0.0 1.4e-77 260.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 KOO31224.1 - 1e-58 197.9 0.0 2e-58 196.9 0.0 1.5 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 MT PF12777.2 KOO31224.1 - 1.5e-56 191.6 9.3 2.3e-56 191.0 6.5 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 KOO31224.1 - 1.7e-08 33.9 0.0 4.3e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 DUF3810 PF12725.2 KOO31224.1 - 0.29 9.9 0.3 0.56 9.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Oxysterol_BP PF01237.13 KOO31224.1 - 1.5 7.2 0.6 2.4 6.5 0.4 1.2 1 0 0 1 1 1 0 Oxysterol-binding protein LSM PF01423.17 KOO31226.1 - 4.8e-23 80.4 0.5 5.5e-23 80.3 0.3 1.0 1 0 0 1 1 1 1 LSM domain Methyltransf_23 PF13489.1 KOO31227.1 - 9.6e-07 28.6 0.0 1.1e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO31227.1 - 0.087 12.4 0.0 0.096 12.2 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain HEAT PF02985.17 KOO31228.1 - 0.0031 17.4 0.1 0.0075 16.2 0.0 1.7 1 0 0 1 1 1 1 HEAT repeat NPR3 PF03666.8 KOO31229.1 - 1.7e-08 33.4 0.0 0.00032 19.3 0.0 3.9 3 1 1 4 4 4 4 Nitrogen Permease regulator of amino acid transport activity 3 Pyr_redox PF00070.22 KOO31230.1 - 5.4e-05 23.5 0.1 0.00047 20.5 0.1 2.1 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 KOO31230.1 - 0.00066 18.2 0.1 0.0011 17.5 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.9 KOO31230.1 - 0.0035 17.2 0.0 0.0052 16.6 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOO31230.1 - 0.0072 16.3 0.0 0.018 15.1 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 KOO31230.1 - 0.0073 15.2 0.2 0.014 14.2 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 KOO31230.1 - 0.0093 15.9 0.1 0.029 14.3 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOO31230.1 - 0.024 13.5 4.7 0.23 10.3 0.4 2.4 1 1 1 2 2 2 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 KOO31230.1 - 0.049 12.6 0.2 0.093 11.7 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.7 KOO31230.1 - 0.055 12.3 0.1 0.092 11.6 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Dynamin_M PF01031.15 KOO31231.1 - 3.3e-23 81.9 0.2 1e-22 80.2 0.1 1.7 1 1 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.18 KOO31231.1 - 8.7e-16 58.1 0.0 2e-15 57.0 0.0 1.6 1 0 0 1 1 1 1 Dynamin family GED PF02212.13 KOO31231.1 - 7.2e-09 35.4 0.4 7.2e-09 35.4 0.3 2.4 2 1 0 2 2 2 1 Dynamin GTPase effector domain TMP_2 PF06791.8 KOO31231.1 - 0.072 12.7 0.9 0.12 11.9 0.1 1.7 2 0 0 2 2 2 0 Prophage tail length tape measure protein MMR_HSR1 PF01926.18 KOO31231.1 - 0.1 12.5 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase GBP PF02263.14 KOO31233.1 - 1.3e-62 211.2 0.0 1.6e-62 210.9 0.0 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.9 KOO31233.1 - 2e-13 50.1 0.0 2.7e-13 49.7 0.0 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain Arm PF00514.18 KOO31234.1 - 2.1e-91 296.9 73.4 5.4e-06 26.0 0.6 18.3 18 0 0 18 18 18 18 Armadillo/beta-catenin-like repeat RPAP1_C PF08620.5 KOO31234.1 - 5.1e-07 29.4 0.0 46 3.9 0.0 10.7 16 0 0 16 16 16 0 RPAP1-like, C-terminal Arm_2 PF04826.8 KOO31234.1 - 2.8e-06 26.6 38.9 0.23 10.5 0.5 7.8 2 2 5 8 8 8 7 Armadillo-like Acyl-CoA_dh_N PF02771.11 KOO31234.1 - 0.028 14.9 44.7 23 5.6 0.2 13.4 4 4 10 15 15 15 0 Acyl-CoA dehydrogenase, N-terminal domain Atx10homo_assoc PF09759.4 KOO31234.1 - 0.037 13.7 10.2 0.31 10.7 0.0 5.2 3 3 2 5 5 5 0 Spinocerebellar ataxia type 10 protein domain HECT PF00632.20 KOO31234.1 - 0.041 13.0 0.0 0.072 12.2 0.0 1.3 1 0 0 1 1 1 0 HECT-domain (ubiquitin-transferase) HEAT PF02985.17 KOO31234.1 - 4.4 7.6 42.9 42 4.5 0.1 13.7 17 0 0 17 17 17 0 HEAT repeat Reprolysin_5 PF13688.1 KOO31234.1 - 6.3 6.6 9.1 70 3.2 0.0 4.9 3 1 0 5 5 5 0 Metallo-peptidase family M12 Ribonuc_red_lgC PF02867.10 KOO31235.1 - 1.7e-215 716.6 0.0 2.1e-215 716.3 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 KOO31235.1 - 8.8e-24 83.1 0.0 1.9e-23 82.0 0.0 1.6 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 KOO31235.1 - 1.7e-17 63.5 0.0 5e-17 62.1 0.0 1.9 2 0 0 2 2 2 1 ATP cone domain TMP_2 PF06791.8 KOO31235.1 - 0.065 12.8 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 Prophage tail length tape measure protein NDK PF00334.14 KOO31236.1 - 1.9e-06 27.7 0.0 0.022 14.5 0.0 2.2 2 0 0 2 2 2 2 Nucleoside diphosphate kinase EF-hand_1 PF00036.27 KOO31237.1 - 4.4e-27 91.2 6.7 1.6e-06 26.9 0.0 5.8 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.1 KOO31237.1 - 6e-27 93.5 2.4 1.3e-10 41.2 0.1 4.5 4 1 1 5 5 5 4 EF-hand domain pair EF-hand_8 PF13833.1 KOO31237.1 - 6.5e-23 80.1 14.5 9.2e-05 21.9 0.0 6.3 3 3 3 6 6 6 5 EF-hand domain pair EF-hand_5 PF13202.1 KOO31237.1 - 2.4e-20 70.9 13.8 4.5e-06 25.7 0.0 6.2 5 2 2 7 7 7 4 EF hand EF-hand_6 PF13405.1 KOO31237.1 - 2.5e-18 64.2 6.8 0.00021 20.9 0.0 5.9 5 1 1 6 6 6 4 EF-hand domain RIIa PF02197.12 KOO31237.1 - 2.2e-09 36.5 0.4 7e-09 34.9 0.3 1.9 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit EF-hand_4 PF12763.2 KOO31237.1 - 3.3e-09 36.3 2.9 0.03 14.0 0.0 5.0 2 1 3 5 5 5 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO31237.1 - 4.2e-06 26.7 0.1 0.015 15.2 0.0 2.4 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO31237.1 - 2.9e-05 23.6 1.5 0.51 10.0 0.0 4.7 4 2 1 5 5 5 2 EF hand ADH_N PF08240.7 KOO31238.1 - 1.4e-31 108.4 1.0 2.9e-31 107.4 0.7 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 KOO31238.1 - 3.5e-22 78.3 1.9 8.8e-22 77.0 1.3 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase LRR_6 PF13516.1 KOO31238.1 - 1e-16 59.0 20.1 0.0086 16.0 0.0 9.0 9 0 0 9 9 9 5 Leucine Rich repeat LRR_4 PF12799.2 KOO31238.1 - 1.7e-07 30.6 0.5 0.0036 16.8 0.0 5.0 4 2 1 5 5 5 1 Leucine Rich repeats (2 copies) 2-Hacid_dh_C PF02826.14 KOO31238.1 - 0.0015 17.7 0.0 0.0034 16.5 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain LRR_1 PF00560.28 KOO31238.1 - 0.0044 16.8 6.9 35 4.9 0.0 6.4 6 1 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.1 KOO31238.1 - 0.0046 16.6 5.5 0.46 10.2 0.2 4.9 4 1 2 6 6 6 3 Leucine rich repeat ATG16 PF08614.6 KOO31238.1 - 0.013 15.3 7.4 0.023 14.5 5.1 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) LRR_7 PF13504.1 KOO31238.1 - 0.019 15.0 11.4 59 4.5 0.1 7.0 8 0 0 8 8 7 0 Leucine rich repeat DUF4407 PF14362.1 KOO31238.1 - 1.1 8.2 11.6 1.9 7.3 8.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spc7 PF08317.6 KOO31238.1 - 1.4 7.4 6.6 2.1 6.9 4.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Mod_r PF07200.8 KOO31238.1 - 6.9 6.5 11.5 11 5.9 0.3 2.4 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Glyco_transf_8 PF01501.15 KOO31239.1 - 6.6e-19 68.2 0.0 2.1e-18 66.6 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferase family 8 Sulfotransfer_3 PF13469.1 KOO31239.1 - 9.9e-11 42.8 0.2 9.9e-11 42.8 0.2 3.3 1 1 1 2 2 2 1 Sulfotransferase family Kelch_3 PF13415.1 KOO31240.1 - 1.2e-26 92.2 10.0 8.9e-08 32.0 0.1 5.7 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_4 PF13418.1 KOO31240.1 - 3.2e-26 90.8 9.6 5.5e-06 26.0 0.0 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO31240.1 - 4.5e-21 74.3 4.0 2.7e-05 23.9 0.0 6.7 6 1 0 6 6 6 5 Kelch motif Kelch_2 PF07646.10 KOO31240.1 - 2.4e-17 61.9 2.9 6.9e-06 25.6 0.0 5.9 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.1 KOO31240.1 - 8.5e-16 57.3 4.0 7e-05 22.8 0.0 6.1 3 2 3 6 6 6 3 Kelch motif Kelch_1 PF01344.20 KOO31240.1 - 1.1e-12 47.2 0.0 0.00012 21.5 0.0 4.8 5 0 0 5 5 5 2 Kelch motif MAD PF05557.8 KOO31241.1 - 1.5e-05 23.3 1.6 1.5e-05 23.3 1.1 5.5 4 2 0 4 4 4 3 Mitotic checkpoint protein FA_synthesis PF02504.10 KOO31241.1 - 0.019 13.8 0.5 0.019 13.8 0.4 2.3 2 0 0 2 2 2 0 Fatty acid synthesis protein ARL2_Bind_BART PF11527.3 KOO31242.1 - 3.3e-35 120.5 0.9 6.2e-35 119.6 0.6 1.5 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART UIM PF02809.15 KOO31242.1 - 1.3 8.7 26.8 0.46 10.2 2.7 4.8 4 0 0 4 4 4 0 Ubiquitin interaction motif Spermine_synth PF01564.12 KOO31243.1 - 2.7e-05 23.2 0.0 4.8e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_18 PF12847.2 KOO31243.1 - 3.3e-05 24.4 0.1 3.3e-05 24.4 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO31243.1 - 9.6e-05 22.3 0.5 9.6e-05 22.3 0.3 2.8 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO31243.1 - 0.14 12.6 0.0 0.66 10.4 0.0 2.3 1 0 0 1 1 1 0 Methyltransferase domain SET PF00856.23 KOO31244.1 - 1.2e-10 41.9 0.1 1.8e-08 34.8 0.0 2.4 2 0 0 2 2 2 2 SET domain Cu2_monoox_C PF03712.10 KOO31245.1 - 1.3e-07 31.1 0.0 0.0013 18.1 0.0 2.1 2 0 0 2 2 2 2 Copper type II ascorbate-dependent monooxygenase, C-terminal domain Myb_DNA-binding PF00249.26 KOO31246.1 - 1.8e-08 34.2 0.0 2.6e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain AAA PF00004.24 KOO31247.1 - 7e-38 129.8 0.0 1.4e-37 128.8 0.0 1.5 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO31247.1 - 1.7e-05 24.9 1.6 0.00037 20.5 1.1 2.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.1 KOO31247.1 - 8.4e-05 22.2 0.1 0.00041 20.0 0.1 2.2 1 0 0 1 1 1 1 Part of AAA domain TIP49 PF06068.8 KOO31247.1 - 0.00015 20.6 0.0 0.00036 19.3 0.0 1.5 1 1 1 2 2 2 1 TIP49 C-terminus AAA_22 PF13401.1 KOO31247.1 - 0.00029 20.9 0.0 0.025 14.6 0.0 2.4 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 KOO31247.1 - 0.00061 19.2 0.1 0.0012 18.3 0.1 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_5 PF07728.9 KOO31247.1 - 0.0011 18.6 0.0 0.0037 16.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 KOO31247.1 - 0.0023 17.0 0.0 0.016 14.2 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 KOO31247.1 - 0.0054 17.5 0.0 0.0089 16.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 KOO31247.1 - 0.0064 15.6 0.0 0.015 14.4 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 KOO31247.1 - 0.0092 15.1 0.1 0.018 14.1 0.1 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_25 PF13481.1 KOO31247.1 - 0.0097 15.3 0.6 0.028 13.8 0.4 1.7 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOO31247.1 - 0.027 14.7 0.0 0.042 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 KOO31247.1 - 0.04 13.7 0.0 0.1 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 KOO31247.1 - 0.1 12.5 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 KOO31247.1 - 0.13 11.9 0.1 1.1 8.8 0.0 2.1 1 1 0 2 2 2 0 NACHT domain PhoH PF02562.11 KOO31247.1 - 0.13 11.4 0.0 0.24 10.6 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Sigma54_activat PF00158.21 KOO31247.1 - 0.16 11.4 0.0 0.33 10.4 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Peptidase_C69 PF03577.10 KOO31248.1 - 9.9e-52 176.1 0.0 5.3e-46 157.2 0.0 2.0 2 0 0 2 2 2 2 Peptidase family C69 UBA_4 PF14555.1 KOO31249.1 - 1.4e-11 43.6 0.3 3.1e-11 42.6 0.2 1.6 1 0 0 1 1 1 1 UBA-like domain Thioredoxin_7 PF13899.1 KOO31249.1 - 3.4e-08 33.3 0.0 5.4e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like UBX PF00789.15 KOO31249.1 - 0.00017 21.5 0.0 0.00029 20.8 0.0 1.4 1 0 0 1 1 1 1 UBX domain YukD PF08817.5 KOO31249.1 - 0.11 13.1 0.0 1.2 9.7 0.0 2.3 1 1 1 2 2 2 0 WXG100 protein secretion system (Wss), protein YukD UIM PF02809.15 KOO31249.1 - 0.13 11.8 0.6 0.42 10.3 0.4 1.9 1 0 0 1 1 1 0 Ubiquitin interaction motif Abhydrolase_3 PF07859.8 KOO31250.1 - 8.2e-40 136.6 0.0 1.3e-39 135.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold KIAA1430 PF13879.1 KOO31250.1 - 3.1e-12 46.7 0.7 7.5e-12 45.5 0.5 1.7 1 0 0 1 1 1 1 KIAA1430 homologue DUF2424 PF10340.4 KOO31250.1 - 0.19 10.3 0.1 1.1 7.8 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2424) CAP_GLY PF01302.20 KOO31251.1 - 6e-09 35.4 0.0 1.1e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 CAP-Gly domain IQ PF00612.22 KOO31251.1 - 0.029 14.0 21.8 0.51 10.1 0.1 5.4 5 0 0 5 5 5 0 IQ calmodulin-binding motif Ank_2 PF12796.2 KOO31252.1 - 4.6e-18 65.3 0.3 4.6e-14 52.5 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO31252.1 - 1.5e-15 56.1 0.0 8.9e-06 25.2 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 KOO31252.1 - 4.5e-12 46.1 0.0 6.4e-11 42.4 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO31252.1 - 9.3e-11 41.6 0.1 7.1e-07 29.2 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO31252.1 - 2e-09 36.7 0.0 0.003 17.6 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat EF-hand_1 PF00036.27 KOO31253.1 - 5e-28 94.2 2.3 7.3e-06 24.9 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO31253.1 - 4.7e-24 82.0 4.3 3.3e-05 23.4 0.0 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO31253.1 - 4.3e-22 76.3 6.4 2.1e-05 23.6 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO31253.1 - 2.4e-21 75.6 3.0 7.1e-11 42.0 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO31253.1 - 2.9e-13 49.2 6.1 0.0038 16.8 0.0 4.1 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_10 PF14788.1 KOO31253.1 - 0.013 15.1 1.3 1.1 9.0 0.0 3.1 3 0 0 3 3 3 0 EF hand EF-hand_4 PF12763.2 KOO31253.1 - 0.39 10.4 5.0 3.8 7.3 0.2 3.3 1 1 3 4 4 4 0 Cytoskeletal-regulatory complex EF hand IQ PF00612.22 KOO31254.1 - 2e-06 26.9 19.2 0.46 10.2 0.4 6.2 5 0 0 5 5 5 5 IQ calmodulin-binding motif tRNA-synt_2 PF00152.15 KOO31255.1 - 7.1e-89 297.8 0.0 1e-88 297.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 KOO31255.1 - 2.6e-11 43.1 0.0 7e-11 41.8 0.0 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 KOO31255.1 - 5.6e-10 38.8 0.0 5e-05 22.6 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 KOO31255.1 - 0.0053 16.3 0.1 1.4 8.4 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) Ribosomal_60s PF00428.14 KOO31255.1 - 0.17 12.2 14.2 0.4 11.1 9.8 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein RNA_pol_3_Rpc31 PF11705.3 KOO31255.1 - 0.53 10.1 4.2 0.91 9.4 2.9 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Acetyltransf_1 PF00583.19 KOO31256.1 - 7.7e-05 22.6 0.1 0.00019 21.3 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family SET PF00856.23 KOO31256.1 - 0.00029 21.1 0.0 0.0083 16.4 0.0 2.3 2 0 0 2 2 2 1 SET domain Acetyltransf_7 PF13508.1 KOO31256.1 - 0.017 15.2 0.0 0.03 14.4 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Agenet PF05641.7 KOO31256.1 - 0.044 13.9 0.1 0.32 11.1 0.0 2.3 2 0 0 2 2 2 0 Agenet domain RVT_1 PF00078.22 KOO31257.1 - 0.003 16.9 0.0 0.0041 16.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) YdjO PF14169.1 KOO31257.1 - 0.018 14.4 1.5 0.043 13.2 1.0 1.6 1 0 0 1 1 1 0 Cold-inducible protein YdjO LNS2 PF08235.8 KOO31258.1 - 4.5e-39 133.5 0.0 7.2e-39 132.8 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.9 KOO31258.1 - 3.6e-13 49.1 0.0 9.3e-13 47.8 0.0 1.6 2 0 0 2 2 2 1 lipin, N-terminal conserved region Ank_5 PF13857.1 KOO31258.1 - 3.8e-12 46.0 0.5 4e-11 42.7 0.2 2.7 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO31258.1 - 7.9e-12 45.3 0.2 8.4e-11 42.0 0.1 2.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO31258.1 - 1.3e-10 40.5 2.4 2.9e-09 36.2 0.6 3.6 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.1 KOO31258.1 - 1.3e-08 35.1 0.1 2.2e-07 31.2 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO31258.1 - 3.7e-05 23.5 0.1 0.00047 20.1 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeat DUF1930 PF09122.5 KOO31258.1 - 0.033 13.9 0.0 0.091 12.5 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1930) Apocytochr_F_C PF01333.14 KOO31258.1 - 0.22 11.3 0.0 1.5 8.6 0.0 2.0 2 0 0 2 2 2 0 Apocytochrome F, C-terminal cobW PF02492.14 KOO31259.1 - 2.6e-35 121.4 0.1 3.3e-35 121.1 0.1 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_19 PF13245.1 KOO31259.1 - 0.0011 18.6 1.3 0.0052 16.5 0.9 2.3 1 1 0 1 1 1 1 Part of AAA domain MobB PF03205.9 KOO31259.1 - 0.0031 17.2 0.0 0.0062 16.2 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B UPF0079 PF02367.12 KOO31259.1 - 0.004 16.7 0.0 0.0077 15.8 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 AAA_22 PF13401.1 KOO31259.1 - 0.0057 16.7 0.0 0.011 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 KOO31259.1 - 0.011 15.6 0.1 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 KOO31259.1 - 0.037 13.9 0.2 0.13 12.1 0.1 1.9 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 KOO31259.1 - 0.038 13.9 1.1 0.18 11.7 0.0 2.0 1 1 1 2 2 2 0 AAA ATPase domain AAA_18 PF13238.1 KOO31259.1 - 0.081 13.2 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain HC2 PF07382.6 KOO31260.1 - 0.0027 17.6 24.8 0.0036 17.2 17.2 1.1 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 Thioredoxin_4 PF13462.1 KOO31260.1 - 0.029 14.3 1.6 0.033 14.1 1.1 1.1 1 0 0 1 1 1 0 Thioredoxin Agenet PF05641.7 KOO31261.1 - 0.0091 16.1 0.0 0.15 12.2 0.0 2.4 2 0 0 2 2 2 1 Agenet domain Arb1 PF09692.5 KOO31261.1 - 0.032 13.0 0.0 0.057 12.2 0.0 1.3 1 0 0 1 1 1 0 Argonaute siRNA chaperone (ARC) complex subunit Arb1 CobW_C PF07683.9 KOO31262.1 - 0.0022 17.6 0.0 2.3 7.9 0.0 2.4 2 0 0 2 2 2 2 Cobalamin synthesis protein cobW C-terminal domain iPGM_N PF06415.8 KOO31263.1 - 8.6e-64 214.9 0.0 1.1e-63 214.5 0.0 1.1 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.13 KOO31263.1 - 4e-46 157.4 0.0 5e-46 157.1 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily DUF563 PF04577.9 KOO31264.1 - 4.2e-21 75.8 0.0 5.5e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF563) LRR_6 PF13516.1 KOO31265.1 - 2.8e-12 45.3 1.1 0.028 14.4 0.0 4.9 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.2 KOO31265.1 - 0.00044 19.7 0.0 0.011 15.3 0.0 2.7 3 0 0 3 3 3 1 Leucine Rich repeats (2 copies) Raffinose_syn PF05691.7 KOO31266.1 - 0.044 11.3 0.0 0.082 10.4 0.0 1.3 1 0 0 1 1 1 0 Raffinose synthase or seed imbibition protein Sip1 DUF4326 PF14216.1 KOO31268.1 - 2.8e-06 27.7 0.5 2.8e-06 27.7 0.4 2.5 3 1 0 3 3 3 1 Domain of unknown function (DUF4326) CART PF06373.6 KOO31268.1 - 0.04 13.8 0.4 0.11 12.4 0.3 1.7 1 0 0 1 1 1 0 Cocaine and amphetamine regulated transcript protein (CART) HMG_box PF00505.14 KOO31270.1 - 2.5e-11 43.6 0.0 4.8e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box DUF2263 PF10021.4 KOO31270.1 - 6.8e-10 39.1 0.0 1.4e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) HMG_box_2 PF09011.5 KOO31270.1 - 1.6e-08 34.7 0.0 3.5e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 HMG-box domain EF-hand_1 PF00036.27 KOO31270.1 - 0.0014 17.7 0.3 0.0033 16.6 0.2 1.6 1 0 0 1 1 1 1 EF hand hSac2 PF12456.3 KOO31270.1 - 0.0028 17.0 0.0 0.0064 15.8 0.0 1.5 1 0 0 1 1 1 1 Inositol phosphatase EF-hand_5 PF13202.1 KOO31270.1 - 0.083 12.2 0.3 0.22 10.9 0.2 1.7 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.1 KOO31270.1 - 0.13 12.2 0.3 0.32 10.9 0.2 1.6 1 0 0 1 1 1 0 EF-hand domain API5 PF05918.6 KOO31270.1 - 0.21 10.0 0.0 0.3 9.5 0.0 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Phosphoesterase PF04185.9 KOO31272.1 - 2.5e-45 155.3 0.3 1.3e-44 152.9 0.2 2.0 1 1 0 1 1 1 1 Phosphoesterase family DSBA PF01323.15 KOO31273.1 - 0.0015 18.0 0.0 0.002 17.7 0.0 1.2 1 0 0 1 1 1 1 DSBA-like thioredoxin domain DUF1995 PF09353.5 KOO31275.1 - 0.002 17.8 0.0 0.0031 17.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1995) Pkinase PF00069.20 KOO31277.1 - 1.2e-51 175.4 0.0 1.6e-51 174.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31277.1 - 5.5e-30 104.2 0.0 9e-30 103.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO31277.1 - 0.0047 15.9 0.0 0.0085 15.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO31277.1 - 0.066 12.9 0.3 0.066 12.9 0.2 2.2 2 2 0 2 2 2 0 Phosphotransferase enzyme family EF-hand_7 PF13499.1 KOO31278.1 - 1.1e-17 63.9 2.0 6.2e-09 35.8 0.1 2.0 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO31278.1 - 1.2e-13 49.3 0.1 3.6e-06 25.8 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO31278.1 - 1.1e-11 43.5 0.4 6e-05 22.2 0.1 2.2 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO31278.1 - 5e-11 41.5 0.0 5.1e-05 22.8 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO31278.1 - 3.2e-05 23.4 0.5 0.049 13.2 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair VCBS PF13517.1 KOO31278.1 - 0.13 12.6 5.6 1.5 9.2 0.3 2.3 2 0 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TcdB_toxin_midN PF12256.3 KOO31278.1 - 0.26 10.7 1.6 3.6 7.0 0.1 2.0 1 1 1 2 2 2 0 Insecticide toxin TcdB middle/N-terminal region FG-GAP PF01839.18 KOO31278.1 - 2.8 7.7 9.0 4 7.2 0.3 2.5 2 0 0 2 2 2 0 FG-GAP repeat DcpS_C PF11969.3 KOO31279.1 - 2.3e-22 79.3 0.3 3.5e-22 78.8 0.2 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding AMP-binding PF00501.23 KOO31280.1 - 2.4e-91 306.1 0.2 2.9e-91 305.9 0.1 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 KOO31280.1 - 1.7e-11 44.8 1.2 1.7e-11 44.8 0.9 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain BT1 PF03092.11 KOO31281.1 - 2.3e-13 49.6 21.5 8.2e-07 28.0 9.1 3.1 2 1 0 2 2 2 2 BT1 family MFS_1 PF07690.11 KOO31281.1 - 2.6e-05 23.1 33.0 2.6e-05 23.1 22.9 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Herpes_UL49_5 PF05702.6 KOO31281.1 - 0.0039 17.0 0.7 0.0039 17.0 0.5 2.7 3 0 0 3 3 3 1 Herpesvirus UL49.5 envelope/tegument protein CS PF04969.11 KOO31282.1 - 2.5e-12 47.1 0.0 3.8e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 CS domain Arm PF00514.18 KOO31283.1 - 9.9e-38 126.7 19.2 2.5e-07 30.2 0.0 6.8 8 0 0 8 8 8 6 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO31283.1 - 3.4e-09 36.8 8.8 1.9e-05 24.8 3.2 4.1 2 2 1 3 3 3 2 HEAT repeats V-ATPase_H_N PF03224.9 KOO31283.1 - 5.5e-06 25.7 0.0 0.0046 16.1 0.0 2.1 1 1 1 2 2 2 2 V-ATPase subunit H HEAT PF02985.17 KOO31283.1 - 0.00022 21.0 16.6 0.37 10.9 0.0 5.7 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.1 KOO31283.1 - 0.011 16.1 23.3 0.27 11.7 1.1 5.8 2 2 4 6 6 6 0 HEAT-like repeat RICTOR_N PF14664.1 KOO31283.1 - 0.014 14.0 0.0 2.8 6.4 0.0 2.2 1 1 1 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term Glyco_hydro_47 PF01532.15 KOO31284.1 - 3.8e-116 388.4 0.0 7e-116 387.5 0.0 1.3 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 Pro_isomerase PF00160.16 KOO31285.1 - 1.2e-22 80.7 0.1 1.4e-22 80.6 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PRK PF00485.13 KOO31286.1 - 6.3e-62 208.5 0.0 8.9e-62 208.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_17 PF13207.1 KOO31286.1 - 0.0006 20.6 0.0 0.0054 17.5 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 KOO31286.1 - 0.026 14.8 0.0 0.21 11.9 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_23 PF13476.1 KOO31286.1 - 0.11 12.7 0.6 0.15 12.3 0.4 1.5 1 1 0 1 1 1 0 AAA domain RNA_pol_Rpb8 PF03870.10 KOO31287.1 - 1e-39 135.8 0.1 1.2e-39 135.6 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 CCT PF06203.9 KOO31287.1 - 0.041 13.5 0.1 0.077 12.6 0.1 1.4 1 0 0 1 1 1 0 CCT motif Arm PF00514.18 KOO31288.1 - 1e-39 132.9 24.8 5.5e-08 32.3 0.1 7.7 6 1 1 7 7 7 7 Armadillo/beta-catenin-like repeat U-box PF04564.10 KOO31288.1 - 5.5e-16 58.2 0.1 9e-16 57.6 0.0 1.3 1 0 0 1 1 1 1 U-box domain Arm_2 PF04826.8 KOO31288.1 - 1.6e-14 53.6 0.0 0.0019 17.3 0.0 4.1 1 1 3 4 4 4 4 Armadillo-like zf-Nse PF11789.3 KOO31288.1 - 0.00044 19.7 0.0 0.00098 18.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit MOZART1 PF12554.3 KOO31288.1 - 0.24 10.8 6.6 1.7e+02 1.7 0.0 5.5 6 0 0 6 6 6 0 Mitotic-spindle organizing gamma-tubulin ring associated Acetyltransf_1 PF00583.19 KOO31289.1 - 0.054 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Arm PF00514.18 KOO31290.1 - 2.7e-11 42.8 4.0 3.7e-05 23.3 0.0 3.8 3 1 1 4 4 4 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO31290.1 - 0.009 16.2 2.8 0.043 14.1 1.9 2.2 1 1 0 1 1 1 1 HEAT repeats MotA_ExbB PF01618.11 KOO31290.1 - 0.025 14.1 0.6 0.16 11.6 0.0 2.0 1 1 1 2 2 2 0 MotA/TolQ/ExbB proton channel family XOO_2897-deam PF14440.1 KOO31290.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase MORN PF02493.15 KOO31291.1 - 3e-29 98.9 32.3 1.2e-07 31.0 2.3 5.4 5 0 0 5 5 5 5 MORN repeat DUF4366 PF14283.1 KOO31293.1 - 0.001 18.5 0.0 0.0013 18.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4366) Phage_HK97_TLTM PF06120.6 KOO31293.1 - 0.093 12.0 0.5 0.13 11.5 0.4 1.1 1 0 0 1 1 1 0 Tail length tape measure protein MFS_1 PF07690.11 KOO31296.1 - 3.1e-09 36.0 17.1 3.1e-09 36.0 11.8 3.1 2 2 0 2 2 2 1 Major Facilitator Superfamily SPX PF03105.14 KOO31296.1 - 0.0095 15.7 0.3 0.049 13.4 0.0 2.1 1 1 1 2 2 2 1 SPX domain TPR_12 PF13424.1 KOO31297.1 - 3.4e-17 62.1 38.2 1e-07 31.7 3.5 2.7 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.1 KOO31297.1 - 1e-06 28.0 14.1 0.0011 18.5 0.2 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO31297.1 - 2.1e-06 27.0 7.5 0.15 11.6 0.5 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.1 KOO31297.1 - 9.1e-06 25.4 24.4 0.0056 16.5 2.4 4.3 3 1 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 KOO31297.1 - 7e-05 22.3 14.2 0.0028 17.2 3.8 3.0 2 1 1 3 3 3 3 TPR repeat TPR_2 PF07719.12 KOO31297.1 - 7.3e-05 22.3 22.9 0.091 12.7 2.1 4.4 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO31297.1 - 0.0068 16.1 3.1 6 6.8 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO31297.1 - 0.015 15.4 6.0 2 8.8 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO31297.1 - 0.028 15.0 27.2 0.089 13.4 0.2 4.8 2 1 3 5 5 4 0 Tetratricopeptide repeat Prefoldin PF02996.12 KOO31297.1 - 0.065 12.8 0.2 0.94 9.1 0.0 2.6 2 1 0 2 2 2 0 Prefoldin subunit TPR_19 PF14559.1 KOO31297.1 - 0.33 11.3 22.1 0.17 12.2 1.7 3.6 2 1 2 4 4 4 0 Tetratricopeptide repeat ANTAR PF03861.9 KOO31297.1 - 0.52 9.9 7.6 1.5 8.4 0.5 3.0 3 0 0 3 3 3 0 ANTAR domain Arginosuc_synth PF00764.14 KOO31298.1 - 7e-73 245.8 0.0 8.3e-73 245.6 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase Asn_synthase PF00733.16 KOO31298.1 - 0.001 18.6 0.0 0.0016 18.0 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.8 KOO31298.1 - 0.0012 18.2 0.0 0.0019 17.5 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC DUF1320 PF07030.7 KOO31298.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1320) Cupin_2 PF07883.6 KOO31299.1 - 0.0019 17.6 0.3 0.0048 16.3 0.0 1.7 1 1 1 2 2 2 1 Cupin domain AraC_binding_2 PF14525.1 KOO31299.1 - 0.0034 16.9 0.0 0.0038 16.8 0.0 1.2 1 1 0 1 1 1 1 AraC-binding-like domain Cupin_6 PF12852.2 KOO31299.1 - 0.049 13.2 0.0 0.053 13.1 0.0 1.1 1 0 0 1 1 1 0 Cupin PEN-2 PF10251.4 KOO31300.1 - 3.7e-15 55.9 0.1 4.4e-15 55.6 0.1 1.1 1 0 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase Cation_efflux PF01545.16 KOO31300.1 - 0.12 11.4 0.1 0.14 11.2 0.1 1.1 1 0 0 1 1 1 0 Cation efflux family PAP2 PF01569.16 KOO31300.1 - 0.15 11.7 2.0 0.22 11.2 1.4 1.2 1 0 0 1 1 1 0 PAP2 superfamily Atg14 PF10186.4 KOO31301.1 - 0.0075 15.2 5.3 0.0095 14.9 3.7 1.1 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 ERM PF00769.14 KOO31301.1 - 0.021 14.3 14.5 0.026 14.0 10.1 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family V_ATPase_I PF01496.14 KOO31301.1 - 0.022 12.6 0.9 0.024 12.4 0.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2458 PF10454.4 KOO31301.1 - 0.9 9.4 8.0 1.8 8.4 5.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2458) DUF3584 PF12128.3 KOO31301.1 - 0.97 6.6 16.8 1.2 6.3 11.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Spc7 PF08317.6 KOO31301.1 - 1.6 7.3 9.4 2 6.9 6.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Peptidase_S46 PF10459.4 KOO31301.1 - 2.7 6.2 9.7 3.6 5.8 6.7 1.1 1 0 0 1 1 1 0 Peptidase S46 PBP_sp32 PF07222.7 KOO31301.1 - 9 5.3 13.1 3.8 6.6 1.0 2.1 1 1 1 2 2 2 0 Proacrosin binding protein sp32 Methyltransf_21 PF05050.7 KOO31303.1 - 0.0027 17.6 0.0 0.0043 17.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_26 PF13659.1 KOO31303.1 - 0.093 12.7 0.7 0.17 11.9 0.5 1.7 1 1 0 1 1 1 0 Methyltransferase domain START PF01852.14 KOO31304.1 - 0.0026 17.1 0.3 0.0034 16.7 0.2 1.2 1 0 0 1 1 1 1 START domain NAD_binding_1 PF00175.16 KOO31305.1 - 4.4e-24 85.1 0.0 1.1e-23 83.9 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 KOO31305.1 - 3.7e-05 23.6 0.0 0.00079 19.3 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Glyco_hydro_38C PF07748.8 KOO31305.1 - 9.7e-05 21.3 0.0 0.00018 20.4 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain CAP_GLY PF01302.20 KOO31306.1 - 3.7e-14 52.1 0.1 6.2e-14 51.4 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain Isochorismatase PF00857.15 KOO31306.1 - 4.5e-14 52.7 0.0 9.4e-06 25.6 0.0 2.2 2 0 0 2 2 2 2 Isochorismatase family WW PF00397.21 KOO31307.1 - 0.00021 21.0 0.2 0.00041 20.1 0.1 1.5 1 0 0 1 1 1 1 WW domain DUF4238 PF14022.1 KOO31307.1 - 0.035 13.3 0.2 0.035 13.3 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4238) YtxH PF12732.2 KOO31307.1 - 0.13 12.6 0.4 0.13 12.6 0.2 4.7 3 1 0 3 3 3 0 YtxH-like protein GAS PF13851.1 KOO31307.1 - 1.6 7.8 27.1 0.63 9.2 6.2 3.0 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding HAD_2 PF13419.1 KOO31310.1 - 2e-16 60.7 0.0 4.5e-16 59.5 0.0 1.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOO31310.1 - 4e-07 30.6 0.1 5.6e-06 26.9 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOO31310.1 - 6.8e-05 22.4 0.0 0.00012 21.7 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.2 KOO31310.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.5 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase NT5C PF06941.7 KOO31310.1 - 0.16 11.4 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) GHMP_kinases_C PF08544.8 KOO31311.1 - 0.1 12.7 0.0 0.15 12.3 0.0 1.3 1 1 0 1 1 1 0 GHMP kinases C terminal DUF3670 PF12419.3 KOO31312.1 - 0.078 12.4 0.8 0.13 11.7 0.4 1.4 1 1 0 1 1 1 0 SNF2 Helicase protein Arena_nucleocap PF00843.12 KOO31312.1 - 0.13 10.1 1.3 0.13 10.1 0.9 1.1 1 0 0 1 1 1 0 Arenavirus nucleocapsid protein Thymidylat_synt PF00303.14 KOO31314.1 - 3e-104 347.7 0.0 4.2e-104 347.3 0.0 1.1 1 0 0 1 1 1 1 Thymidylate synthase DHFR_1 PF00186.14 KOO31314.1 - 2.8e-31 108.2 0.0 3.4e-29 101.5 0.0 2.3 2 0 0 2 2 2 2 Dihydrofolate reductase SKI PF01202.17 KOO31315.1 - 1.6e-07 31.3 0.0 2.6e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.1 KOO31315.1 - 1.4e-06 28.2 0.0 2.8e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOO31315.1 - 0.00053 20.2 0.0 0.00094 19.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO31315.1 - 0.00061 20.6 0.0 0.0014 19.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF3506 PF12014.3 KOO31315.1 - 0.0023 17.7 0.0 0.04 13.7 0.0 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF3506) AAA_22 PF13401.1 KOO31315.1 - 0.061 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.20 KOO31316.1 - 3.6e-49 167.2 0.0 4.3e-49 166.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31316.1 - 2.4e-20 72.6 0.0 3.3e-20 72.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO31316.1 - 0.00072 19.3 0.1 0.0014 18.4 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 KOO31316.1 - 0.21 10.9 0.1 1.2 8.3 0.0 1.9 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Choline_kinase PF01633.15 KOO31316.1 - 0.21 11.1 0.0 0.38 10.2 0.0 1.4 1 1 0 1 1 1 0 Choline/ethanolamine kinase Aldo_ket_red PF00248.16 KOO31317.1 - 1.1e-05 24.3 0.0 2.1e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family Fasciclin PF02469.17 KOO31318.1 - 1.4e-35 122.0 0.0 2e-35 121.5 0.0 1.2 1 0 0 1 1 1 1 Fasciclin domain RVT_2 PF07727.9 KOO31319.1 - 1.3e-25 89.7 0.0 2e-25 89.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.19 KOO31319.1 - 0.13 12.5 0.0 0.24 11.7 0.0 1.4 1 0 0 1 1 1 0 RNase H EF-hand_1 PF00036.27 KOO31320.1 - 4.9e-16 56.7 2.5 4.1e-05 22.5 0.1 3.7 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 KOO31320.1 - 3.5e-15 54.4 6.7 0.00026 20.6 0.1 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.1 KOO31320.1 - 2.3e-13 50.0 4.4 1.2e-08 34.9 0.5 3.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO31320.1 - 4.2e-10 38.5 9.0 0.00078 18.6 0.5 3.8 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 KOO31320.1 - 1.3e-08 34.2 2.9 0.011 15.2 0.0 3.8 2 1 1 3 3 3 3 EF-hand domain pair IQ PF00612.22 KOO31321.1 - 0.0093 15.5 0.1 0.03 13.9 0.1 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif Neur_chan_memb PF02932.11 KOO31322.1 - 0.0035 17.2 0.8 0.0035 17.2 0.5 1.9 2 1 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region DEAD PF00270.24 KOO31324.1 - 0.00019 20.9 0.0 0.0013 18.2 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 KOO31324.1 - 0.0029 17.4 0.0 0.094 12.5 0.0 2.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Thioredoxin PF00085.15 KOO31325.1 - 1.5e-27 95.3 0.0 2.3e-27 94.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin PUB PF09409.5 KOO31325.1 - 1.2e-19 69.7 0.0 1.8e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 PUB domain Thioredoxin_8 PF13905.1 KOO31325.1 - 5.1e-07 29.7 0.0 9.3e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 KOO31325.1 - 2.2e-05 24.5 0.0 0.00043 20.4 0.0 2.4 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.1 KOO31325.1 - 0.00084 19.3 0.2 0.003 17.5 0.2 1.9 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.1 KOO31325.1 - 0.0012 18.4 0.0 0.0019 17.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.16 KOO31325.1 - 0.0015 18.2 0.0 0.0031 17.1 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 KOO31325.1 - 0.0077 15.7 0.0 0.096 12.2 0.0 2.2 1 1 0 2 2 2 1 Redoxin 2OG-FeII_Oxy_3 PF13640.1 KOO31326.1 - 8.4e-17 61.5 0.0 7.9e-16 58.4 0.0 2.3 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily CS PF04969.11 KOO31326.1 - 6.1e-07 29.9 0.0 1.1e-06 29.0 0.0 1.4 1 0 0 1 1 1 1 CS domain 2OG-FeII_Oxy_4 PF13661.1 KOO31326.1 - 0.00052 19.6 0.0 0.0011 18.5 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Tet_JBP PF12851.2 KOO31326.1 - 0.12 11.6 0.0 0.24 10.6 0.0 1.4 1 0 0 1 1 1 0 Oxygenase domain of the 2OGFeDO superfamily Prok-E2_C PF14459.1 KOO31328.1 - 0.078 13.0 1.4 0.14 12.2 1.0 1.6 1 0 0 1 1 1 0 Prokaryotic E2 family C V_ATPase_I PF01496.14 KOO31328.1 - 0.6 7.8 7.8 0.7 7.6 5.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TBPIP PF07106.8 KOO31328.1 - 1.4 8.4 12.9 4.2 6.8 5.2 2.8 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) ATP-synt_D PF01813.12 KOO31328.1 - 1.6 8.2 14.5 0.11 12.0 5.1 2.2 1 1 1 2 2 2 0 ATP synthase subunit D DUF972 PF06156.8 KOO31328.1 - 2 8.8 12.0 1.9 8.8 1.2 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF972) TMF_DNA_bd PF12329.3 KOO31328.1 - 3 7.7 18.5 6.4 6.6 5.5 3.3 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Muted PF14942.1 KOO31328.1 - 3.7 7.4 11.8 15 5.4 7.9 2.1 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein NPV_P10 PF05531.7 KOO31328.1 - 4.2 7.6 5.4 20 5.5 1.5 2.9 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF3584 PF12128.3 KOO31328.1 - 9 3.4 24.8 12 3.1 17.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Fringe PF02434.11 KOO31329.1 - 6.4e-10 38.6 0.2 3.7e-09 36.1 0.1 2.1 1 1 0 1 1 1 1 Fringe-like Sulfotransfer_1 PF00685.22 KOO31329.1 - 3.3e-08 33.1 0.1 2.1e-07 30.5 0.0 2.2 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.1 KOO31329.1 - 4.5e-06 27.6 0.0 4.5e-06 27.6 0.0 3.7 3 0 0 3 3 3 1 Sulfotransferase family FOP_dimer PF09398.5 KOO31329.1 - 0.00065 19.6 0.0 0.0021 18.0 0.0 1.8 1 0 0 1 1 1 1 FOP N terminal dimerisation domain Sulfotransfer_2 PF03567.9 KOO31329.1 - 0.0011 18.7 0.1 0.0031 17.2 0.0 1.8 1 0 0 1 1 1 1 Sulfotransferase family DUF1375 PF07119.7 KOO31330.1 - 0.012 15.4 0.2 0.23 11.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1375) CRAL_TRIO PF00650.15 KOO31331.1 - 6.3e-11 42.0 0.0 4.3e-10 39.2 0.0 2.0 1 1 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.1 KOO31331.1 - 0.0051 16.7 0.0 0.0082 16.0 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Proteasome PF00227.21 KOO31334.1 - 9.7e-46 155.4 0.0 1.2e-45 155.1 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 KOO31334.1 - 1.3e-14 53.2 0.0 2.5e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature HEAT_EZ PF13513.1 KOO31335.1 - 0.056 13.9 25.9 5.4 7.6 1.5 8.6 8 2 0 8 8 8 0 HEAT-like repeat MIP PF00230.15 KOO31336.1 - 1.1e-06 28.3 8.5 5.3e-06 26.0 5.8 2.0 1 1 0 1 1 1 1 Major intrinsic protein Cytochrom_B_C PF00032.12 KOO31336.1 - 1.1 9.5 6.0 0.24 11.6 1.5 1.9 2 0 0 2 2 2 0 Cytochrome b(C-terminal)/b6/petD LRR_6 PF13516.1 KOO31337.1 - 0.05 13.6 0.6 0.15 12.2 0.4 1.8 1 0 0 1 1 1 0 Leucine Rich repeat LRR_1 PF00560.28 KOO31337.1 - 0.12 12.4 0.2 0.29 11.2 0.1 1.7 1 0 0 1 1 1 0 Leucine Rich Repeat TrkA_C PF02080.16 KOO31337.1 - 0.14 11.8 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 TrkA-C domain Proteasome PF00227.21 KOO31338.1 - 0.002 17.4 0.1 0.0027 17.0 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Rotavirus_VP3 PF06929.6 KOO31338.1 - 0.024 12.5 0.0 0.026 12.4 0.0 1.0 1 0 0 1 1 1 0 Rotavirus VP3 protein PX PF00787.19 KOO31338.1 - 0.032 14.0 0.0 0.04 13.7 0.0 1.2 1 0 0 1 1 1 0 PX domain Phage_P2_GpU PF06995.6 KOO31339.1 - 0.024 14.0 1.4 0.032 13.5 1.0 1.4 1 1 0 1 1 1 0 Phage P2 GpU IncA PF04156.9 KOO31339.1 - 0.89 9.1 9.1 0.14 11.7 3.8 1.5 2 0 0 2 2 2 0 IncA protein adh_short PF00106.20 KOO31341.1 - 2.1e-06 27.7 0.2 3e-06 27.2 0.2 1.3 1 0 0 1 1 1 1 short chain dehydrogenase DUF1776 PF08643.5 KOO31341.1 - 0.00047 19.3 0.0 0.00055 19.1 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) adh_short_C2 PF13561.1 KOO31341.1 - 0.00047 19.9 0.8 0.00051 19.8 0.5 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Cpn60_TCP1 PF00118.19 KOO31342.1 - 1.1e-137 459.6 6.8 1.2e-137 459.4 4.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Dak2 PF02734.12 KOO31342.1 - 0.017 14.8 1.2 0.18 11.4 0.2 2.6 2 0 0 2 2 2 0 DAK2 domain SidE PF12252.3 KOO31343.1 - 0.15 9.3 0.0 0.22 8.8 0.0 1.1 1 0 0 1 1 1 0 Dot/Icm substrate protein Arm PF00514.18 KOO31344.1 - 0.00061 19.5 0.1 2.7 7.9 0.0 3.4 3 0 0 3 3 3 3 Armadillo/beta-catenin-like repeat Biotin_lipoyl PF00364.17 KOO31345.1 - 0.14 11.8 0.1 0.27 10.9 0.1 1.5 1 0 0 1 1 1 0 Biotin-requiring enzyme Ank_2 PF12796.2 KOO31346.1 - 1.2e-16 60.8 0.0 2.8e-10 40.3 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO31346.1 - 3.8e-15 54.8 0.3 4.5e-07 29.3 0.0 4.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.1 KOO31346.1 - 2.5e-14 52.9 4.7 3.6e-06 27.0 0.0 4.3 3 1 2 5 5 5 3 Ankyrin repeats (many copies) HAD_2 PF13419.1 KOO31346.1 - 6e-14 52.6 0.0 1.1e-13 51.8 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Ank_4 PF13637.1 KOO31346.1 - 1e-12 48.1 0.1 5.4e-05 23.5 0.0 3.7 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO31346.1 - 4.7e-11 41.8 0.0 0.00036 20.4 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Hydrolase PF00702.21 KOO31346.1 - 2.5e-10 41.1 0.0 5.1e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOO31346.1 - 7.5e-10 38.3 0.0 7.5e-10 38.3 0.0 2.3 3 0 0 3 3 3 1 HAD-hyrolase-like HAD PF12710.2 KOO31346.1 - 0.032 14.3 0.0 0.071 13.2 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.1 KOO31346.1 - 0.033 14.0 0.0 0.067 13.0 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Pyr_redox_2 PF07992.9 KOO31347.1 - 5.1e-33 114.6 0.0 1.1e-32 113.5 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 KOO31347.1 - 5.7e-32 110.0 1.7 9.8e-32 109.2 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 KOO31347.1 - 3.2e-14 53.0 6.5 3.7e-14 52.8 0.0 3.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 KOO31347.1 - 3.5e-07 29.4 9.9 0.0045 15.8 0.0 2.9 3 0 0 3 3 3 2 FAD binding domain K_oxygenase PF13434.1 KOO31347.1 - 0.00025 20.0 0.1 0.0009 18.2 0.0 1.8 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) 3HCDH_N PF02737.13 KOO31347.1 - 0.00061 19.4 1.2 1.3 8.6 0.0 2.5 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.17 KOO31347.1 - 0.00085 18.2 15.3 0.004 16.0 7.2 2.6 2 1 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.1 KOO31347.1 - 0.0014 18.6 1.2 0.0041 17.2 0.9 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 KOO31347.1 - 0.0082 15.2 4.9 0.012 14.7 3.4 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.9 KOO31347.1 - 0.036 13.4 0.0 0.1 11.9 0.0 1.7 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Thi4 PF01946.12 KOO31347.1 - 0.053 12.6 4.5 0.022 13.8 0.6 2.3 3 0 0 3 3 3 0 Thi4 family DAO PF01266.19 KOO31347.1 - 0.11 11.3 15.7 0.034 13.0 6.3 2.7 2 1 1 3 3 3 0 FAD dependent oxidoreductase DUF2505 PF10698.4 KOO31349.1 - 1.1e-06 28.2 0.0 2.1e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2505) Proteasome PF00227.21 KOO31350.1 - 1.9e-26 92.5 0.1 2.2e-26 92.3 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit CS PF04969.11 KOO31351.1 - 2.5e-11 43.9 0.0 0.0019 18.7 0.0 3.3 3 0 0 3 3 3 3 CS domain BCAS2 PF05700.6 KOO31352.1 - 5.4e-62 209.1 6.6 7e-62 208.7 4.6 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Pkinase PF00069.20 KOO31354.1 - 8.4e-27 93.9 0.0 1.1e-26 93.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31354.1 - 1.6e-24 86.3 0.0 2e-24 86.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO31354.1 - 0.0011 18.7 0.4 0.0023 17.7 0.1 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family RabGAP-TBC PF00566.13 KOO31355.1 - 1.5e-43 148.7 0.3 3.3e-32 111.6 0.0 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Chloroa_b-bind PF00504.16 KOO31356.1 - 1.7e-35 122.5 0.2 2.2e-35 122.2 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein DUF4320 PF14208.1 KOO31357.1 - 0.071 13.0 0.0 0.095 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4320) MBOAT_2 PF13813.1 KOO31358.1 - 3.9e-10 39.6 1.3 3.9e-10 39.6 0.9 2.0 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family MBOAT PF03062.14 KOO31358.1 - 1.2e-07 31.2 2.9 1.9e-07 30.5 2.0 1.4 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family LRR_4 PF12799.2 KOO31359.1 - 1.6e-19 69.0 29.6 4.6e-06 26.1 0.7 11.2 11 2 2 13 13 13 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO31359.1 - 1.2e-13 49.5 31.9 1.7 8.9 0.1 15.8 15 2 2 17 17 17 4 Leucine Rich repeat LRR_8 PF13855.1 KOO31359.1 - 5.7e-12 45.2 35.2 3.7e-05 23.3 3.2 9.7 8 3 2 11 11 11 3 Leucine rich repeat LRR_1 PF00560.28 KOO31359.1 - 2.7e-07 29.6 24.9 13 6.2 0.1 13.0 14 0 0 14 14 14 2 Leucine Rich Repeat FKBP_C PF00254.23 KOO31359.1 - 4.5e-07 29.7 0.0 9.4e-07 28.7 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase NACHT PF05729.7 KOO31359.1 - 0.0023 17.6 0.0 0.0052 16.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain LRR_7 PF13504.1 KOO31359.1 - 0.0063 16.5 32.3 33 5.2 0.1 13.4 14 0 0 14 14 14 0 Leucine rich repeat UvrD-helicase PF00580.16 KOO31359.1 - 0.9 8.7 0.0 1.7 7.8 0.0 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Colicin PF01024.14 KOO31360.1 - 0.0072 15.9 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Colicin pore forming domain Chromo PF00385.19 KOO31361.1 - 1e-09 37.9 0.0 2e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain LysM PF01476.15 KOO31361.1 - 0.00012 21.8 0.0 0.024 14.4 0.0 2.9 3 0 0 3 3 3 1 LysM domain Acetyltransf_1 PF00583.19 KOO31361.1 - 0.0065 16.4 0.0 0.017 15.1 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 KOO31361.1 - 0.14 12.3 0.0 0.32 11.2 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-MIZ PF02891.15 KOO31362.1 - 2.8e-19 68.3 1.8 6.2e-19 67.2 1.2 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.3 KOO31362.1 - 0.00015 21.2 0.2 0.0006 19.2 0.0 2.0 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit Tctex-1 PF03645.8 KOO31364.1 - 1.1e-24 86.2 0.1 1.2e-24 86.1 0.0 1.0 1 0 0 1 1 1 1 Tctex-1 family HRDC PF00570.18 KOO31365.1 - 0.069 12.8 7.8 0.34 10.6 0.0 3.4 3 0 0 3 3 3 0 HRDC domain HTH_32 PF13565.1 KOO31365.1 - 1.1 10.1 8.5 0.17 12.7 0.5 3.2 2 2 1 3 3 3 0 Homeodomain-like domain SGL PF08450.7 KOO31366.1 - 1.2e-59 201.6 0.0 1.5e-59 201.3 0.0 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region Reg_prop PF07494.6 KOO31366.1 - 0.00021 20.9 0.0 0.86 9.8 0.0 3.0 2 0 0 2 2 2 2 Two component regulator propeller NHL PF01436.16 KOO31366.1 - 0.065 13.2 0.2 0.95 9.5 0.1 2.7 2 0 0 2 2 2 0 NHL repeat EF-hand_1 PF00036.27 KOO31367.1 - 1.4e-10 39.6 0.2 0.00029 19.9 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO31367.1 - 2e-09 36.3 0.5 0.00079 18.6 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO31367.1 - 2.3e-09 36.3 0.2 0.00077 19.1 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO31367.1 - 4.8e-08 33.0 0.1 0.0039 17.2 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO31367.1 - 5.7e-05 22.6 0.0 0.39 10.3 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair DUF756 PF05506.7 KOO31367.1 - 0.053 14.0 0.2 4.2 7.9 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF756) TraT PF05818.7 KOO31367.1 - 1.2 8.4 4.4 1.8 7.9 0.2 2.7 3 0 0 3 3 3 0 Enterobacterial TraT complement resistance protein Kelch_4 PF13418.1 KOO31368.1 - 1e-41 140.4 8.2 6.2e-09 35.4 0.0 9.5 10 0 0 10 10 10 7 Galactose oxidase, central domain Kelch_3 PF13415.1 KOO31368.1 - 1.7e-40 136.3 11.3 1.5e-05 24.9 0.0 9.8 9 1 0 9 9 9 8 Galactose oxidase, central domain Kelch_6 PF13964.1 KOO31368.1 - 2e-36 122.6 1.6 0.00049 20.1 0.0 9.5 7 1 2 9 9 9 8 Kelch motif Kelch_5 PF13854.1 KOO31368.1 - 9.3e-35 118.0 7.6 8.7e-06 25.5 0.1 9.7 9 0 0 9 9 9 8 Kelch motif Kelch_1 PF01344.20 KOO31368.1 - 1.3e-31 107.8 1.5 0.0039 16.7 0.0 9.8 9 1 0 9 9 9 8 Kelch motif Kelch_2 PF07646.10 KOO31368.1 - 5.1e-28 95.7 9.0 0.00082 19.0 0.0 9.4 10 0 0 10 10 9 7 Kelch motif Pkinase PF00069.20 KOO31368.1 - 9e-23 80.7 0.1 2.1e-22 79.5 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain SAM_1 PF00536.25 KOO31368.1 - 4.3e-10 39.6 0.1 8.6e-10 38.6 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 KOO31368.1 - 9.3e-09 35.0 0.1 2e-08 33.9 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pkinase_Tyr PF07714.12 KOO31368.1 - 6.9e-08 31.8 0.0 1.7e-07 30.6 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO31368.1 - 9.9e-06 24.7 0.0 4.8e-05 22.4 0.0 1.9 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOO31368.1 - 0.00066 18.8 0.2 0.0014 17.7 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 KOO31368.1 - 0.0044 16.3 0.1 0.008 15.5 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Acyl-CoA_dh_1 PF00441.19 KOO31368.1 - 0.045 13.8 4.4 1.9 8.5 2.4 2.9 2 1 1 3 3 3 0 Acyl-CoA dehydrogenase, C-terminal domain DUF1975 PF09318.5 KOO31368.1 - 0.46 10.0 0.0 0.74 9.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1975) Glyco_hydro_30 PF02055.11 KOO31369.1 - 5.5e-89 298.6 0.0 4.1e-84 282.5 0.0 2.1 2 0 0 2 2 2 2 O-Glycosyl hydrolase family 30 Ricin_B_lectin PF00652.17 KOO31369.1 - 4.1e-11 42.9 0.3 9.8e-11 41.7 0.2 1.7 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain RVT_2 PF07727.9 KOO31370.1 - 8.9e-08 31.3 0.0 6e-07 28.6 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KOO31370.1 - 0.00041 20.4 0.0 0.0011 19.0 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain EF-hand_1 PF00036.27 KOO31371.1 - 2.2e-25 85.9 1.0 1.4e-06 27.1 0.1 4.7 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO31371.1 - 2e-22 79.1 0.3 1.1e-11 44.7 0.1 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO31371.1 - 8.1e-22 75.5 1.7 6.8e-07 28.3 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO31371.1 - 3.6e-21 73.1 3.4 0.00015 21.3 0.0 4.9 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.1 KOO31371.1 - 6.9e-17 60.8 2.4 2e-05 24.1 0.1 4.5 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO31371.1 - 8.2e-06 25.8 0.2 0.097 12.7 0.0 2.8 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO31371.1 - 0.1 12.3 2.6 13 5.5 0.0 3.3 2 2 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand Arm PF00514.18 KOO31372.1 - 2e-73 239.9 46.8 4.6e-07 29.4 0.3 17.1 18 0 0 18 18 18 13 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 KOO31372.1 - 7.2e-12 44.9 3.1 0.28 10.2 0.2 7.1 2 2 5 7 7 7 3 Armadillo-like V-ATPase_H_N PF03224.9 KOO31372.1 - 1.2e-08 34.4 0.0 0.045 12.8 0.0 4.3 2 2 1 3 3 3 3 V-ATPase subunit H HEAT_2 PF13646.1 KOO31372.1 - 4.2e-07 30.1 55.7 0.0031 17.7 2.0 8.9 1 1 6 9 9 9 7 HEAT repeats KAP PF05804.7 KOO31372.1 - 8.1e-06 24.0 0.0 3.2e-05 22.0 0.0 1.9 2 0 0 2 2 2 1 Kinesin-associated protein (KAP) Adaptin_N PF01602.15 KOO31372.1 - 0.0034 15.7 4.6 1.8 6.7 0.3 3.7 3 1 0 4 4 4 2 Adaptin N terminal region HEAT PF02985.17 KOO31372.1 - 0.51 10.5 15.6 13 6.1 0.0 7.4 10 0 0 10 10 10 0 HEAT repeat Arm PF00514.18 KOO31373.1 - 9.8e-68 221.8 52.3 1.3e-06 27.9 0.1 18.7 19 0 0 19 19 19 15 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO31373.1 - 1.4e-05 25.3 62.3 0.044 14.0 3.5 8.3 3 2 7 10 10 10 7 HEAT repeats Atx10homo_assoc PF09759.4 KOO31373.1 - 1.8e-05 24.3 1.5 3.5 7.4 0.0 5.5 3 1 2 5 5 5 2 Spinocerebellar ataxia type 10 protein domain Adaptin_N PF01602.15 KOO31373.1 - 0.0085 14.4 4.6 0.03 12.6 1.8 2.7 2 1 0 2 2 2 1 Adaptin N terminal region V-ATPase_H_C PF11698.3 KOO31373.1 - 0.033 14.1 0.2 3 7.7 0.0 3.4 2 1 1 3 3 3 0 V-ATPase subunit H Tex_N PF09371.5 KOO31373.1 - 1.5 8.1 13.1 5.4 6.2 2.0 3.7 3 0 0 3 3 3 0 Tex-like protein N-terminal domain HEAT_EZ PF13513.1 KOO31373.1 - 9.7 6.8 58.3 0.24 11.9 1.7 11.1 9 3 5 14 14 14 0 HEAT-like repeat DUF2993 PF11209.3 KOO31374.1 - 4.5e-10 39.8 6.3 6.4e-10 39.3 4.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2993) Herpes_U30 PF04523.8 KOO31374.1 - 0.053 10.9 0.0 0.081 10.3 0.0 1.2 1 0 0 1 1 1 0 Herpes virus tegument protein U30 Sulfotransfer_2 PF03567.9 KOO31375.1 - 0.0045 16.6 0.0 0.046 13.4 0.0 2.1 1 1 0 1 1 1 1 Sulfotransferase family DAP_C PF07932.7 KOO31376.1 - 0.031 14.4 0.0 6.4 6.9 0.0 2.5 2 0 0 2 2 2 0 D-aminopeptidase, domain C Imm2 PF14426.1 KOO31376.1 - 0.052 13.5 0.5 4.3 7.4 0.0 2.9 3 0 0 3 3 3 0 Immunity protein Imm2 B9-C2 PF07162.6 KOO31377.1 - 2.9e-29 102.0 0.0 3.8e-29 101.6 0.0 1.1 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein Pkinase PF00069.20 KOO31378.1 - 8.3e-16 57.9 0.0 9.8e-16 57.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31378.1 - 1.7e-07 30.6 0.0 2e-07 30.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO31378.1 - 0.001 18.8 0.0 0.0011 18.7 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family CBM_19 PF03427.8 KOO31378.1 - 0.017 14.9 0.0 0.034 13.9 0.0 1.6 2 0 0 2 2 2 0 Carbohydrate binding domain (family 19) EF-hand_1 PF00036.27 KOO31379.1 - 2e-18 64.2 0.4 1e-05 24.4 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.1 KOO31379.1 - 9e-17 59.5 1.0 1.5e-06 27.3 0.0 3.7 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 KOO31379.1 - 2e-16 58.3 0.9 3.7e-05 23.2 0.0 3.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.1 KOO31379.1 - 5.8e-14 51.9 0.0 2.2e-10 40.4 0.0 2.8 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO31379.1 - 2.3e-09 36.6 0.2 0.00018 21.0 0.0 3.4 2 1 1 3 3 3 2 EF-hand domain pair GPAT_N PF14829.1 KOO31379.1 - 0.09 12.4 0.0 1.4 8.6 0.0 2.4 2 0 0 2 2 2 0 Glycerol-3-phosphate acyltransferase N-terminal TPR_16 PF13432.1 KOO31380.1 - 7e-15 55.2 5.0 2.4e-07 31.2 0.7 2.7 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOO31380.1 - 9.2e-13 47.6 6.1 0.0014 19.0 0.3 4.2 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.1 KOO31380.1 - 1.1e-12 47.3 0.7 3.5e-06 26.5 0.0 2.1 2 0 0 2 2 2 2 TPR repeat TPR_9 PF13371.1 KOO31380.1 - 3.8e-12 45.8 13.1 6.5e-07 29.1 0.3 2.7 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO31380.1 - 1.2e-11 43.5 1.0 0.00056 19.6 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO31380.1 - 1.3e-09 38.2 3.7 0.00054 20.2 0.3 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO31380.1 - 4.9e-09 35.4 1.0 0.0029 17.1 0.1 3.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.1 KOO31380.1 - 2e-07 31.0 2.5 0.44 11.1 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO31380.1 - 1.1e-06 28.4 4.3 0.00031 20.6 0.0 3.2 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO31380.1 - 1.4e-06 28.0 0.0 0.042 14.0 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_20 PF14561.1 KOO31380.1 - 2e-06 27.8 5.1 7.9e-05 22.7 0.4 3.0 1 1 3 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.1 KOO31380.1 - 2.3e-06 26.9 3.0 2e-05 23.7 0.7 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO31380.1 - 3.9e-05 23.1 0.0 0.097 12.5 0.0 3.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO31380.1 - 0.00022 20.7 0.5 14 5.7 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat FAT PF02259.18 KOO31380.1 - 0.00063 18.8 0.5 0.0011 17.9 0.2 1.6 1 1 1 2 2 2 1 FAT domain NARP1 PF12569.3 KOO31380.1 - 0.00083 18.2 0.3 0.42 9.3 0.0 2.0 2 0 0 2 2 2 2 NMDA receptor-regulated protein 1 Apc3 PF12895.2 KOO31380.1 - 0.0015 18.6 0.8 0.33 11.0 0.0 2.6 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 Alkyl_sulf_dimr PF14863.1 KOO31380.1 - 0.0019 18.4 0.7 1.8 8.7 0.0 2.2 1 1 1 2 2 2 2 Alkyl sulfatase dimerisation BTAD PF03704.12 KOO31380.1 - 0.0097 16.2 5.1 0.32 11.3 0.4 2.4 1 1 1 2 2 2 1 Bacterial transcriptional activator domain Clathrin PF00637.15 KOO31380.1 - 0.031 13.8 0.1 0.56 9.7 0.0 2.5 1 1 2 3 3 3 0 Region in Clathrin and VPS RPN7 PF10602.4 KOO31380.1 - 0.033 13.5 0.5 22 4.3 0.0 3.2 3 1 1 4 4 3 0 26S proteasome subunit RPN7 TPR_5 PF12688.2 KOO31380.1 - 0.046 13.7 0.6 0.073 13.1 0.3 1.5 1 1 0 1 1 1 0 Tetratrico peptide repeat MIT PF04212.13 KOO31380.1 - 0.046 13.6 0.2 22 4.9 0.0 3.3 2 2 2 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_10 PF13374.1 KOO31380.1 - 2.2 8.3 0.0 2.2 8.3 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat R3H PF01424.17 KOO31381.1 - 4e-06 26.4 0.2 2.9e-05 23.6 0.0 2.6 2 1 0 2 2 2 1 R3H domain PPR_3 PF13812.1 KOO31381.1 - 7.9e-05 22.6 0.1 1 9.7 0.0 3.4 3 0 0 3 3 3 2 Pentatricopeptide repeat domain RNase_Zc3h12a PF11977.3 KOO31381.1 - 0.0016 18.3 0.0 0.0061 16.3 0.0 1.9 2 0 0 2 2 2 1 Zc3h12a-like Ribonuclease NYN domain PPR PF01535.15 KOO31381.1 - 0.013 15.4 0.1 2.2 8.4 0.0 3.3 4 0 0 4 4 4 0 PPR repeat PPR_2 PF13041.1 KOO31381.1 - 0.11 12.4 0.0 0.33 10.9 0.0 1.8 1 0 0 1 1 1 0 PPR repeat family DUF677 PF05055.7 KOO31382.1 - 0.0019 16.9 0.3 0.0047 15.6 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF677) TerB-C PF15615.1 KOO31382.1 - 0.0025 18.0 0.6 0.0025 18.0 0.4 3.4 2 2 1 3 3 3 1 TerB-C domain DUF2617 PF10936.3 KOO31382.1 - 0.0048 16.4 0.2 0.012 15.1 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function DUF2617 DUF1759 PF03564.10 KOO31382.1 - 0.03 14.1 1.3 0.2 11.4 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) SPX PF03105.14 KOO31382.1 - 0.22 11.2 9.5 0.065 12.9 1.5 2.1 2 0 0 2 2 2 0 SPX domain COG2 PF06148.6 KOO31382.1 - 5.5 6.8 8.0 1.2 9.0 0.4 2.6 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 ShK PF01549.19 KOO31383.1 - 1.4e-15 57.2 41.7 2.4e-09 37.3 6.3 4.5 3 1 0 3 3 3 2 ShK domain-like 2OG-FeII_Oxy PF03171.15 KOO31383.1 - 8.3e-07 29.2 0.1 1.5e-06 28.4 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.1 KOO31383.1 - 5.9e-05 23.5 0.1 0.0001 22.7 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-CCCH PF00642.19 KOO31383.1 - 0.013 15.1 0.1 1.8 8.3 0.0 2.8 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Pkinase PF00069.20 KOO31384.1 - 6.2e-47 159.9 0.0 3e-46 157.6 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31384.1 - 6e-24 84.5 0.0 1.4e-23 83.3 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO31384.1 - 0.00076 18.5 0.0 0.0011 17.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOO31384.1 - 0.072 12.1 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ank_4 PF13637.1 KOO31385.1 - 4.3e-18 65.3 0.4 8.3e-11 42.0 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO31385.1 - 6.9e-15 54.0 0.2 5.5e-07 29.0 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.2 KOO31385.1 - 9.1e-14 51.5 0.1 2.9e-13 49.9 0.1 1.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO31385.1 - 2.7e-12 46.4 0.2 1.9e-09 37.4 0.0 3.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO31385.1 - 1.6e-11 43.2 0.7 1.3e-05 24.9 0.0 3.1 2 1 0 2 2 2 2 Ankyrin repeat ERO1 PF04137.10 KOO31387.1 - 2.5e-72 243.8 0.0 3.5e-72 243.3 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) LRR_5 PF13306.1 KOO31388.1 - 2.1e-63 211.7 0.0 8.9e-32 109.5 0.0 2.0 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO31388.1 - 8.3e-14 51.0 0.0 0.00021 20.9 0.0 3.4 1 1 2 3 3 3 3 Leucine rich repeat DUF3620 PF12281.3 KOO31388.1 - 0.014 15.0 0.0 1 9.0 0.0 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3620) FeS PF04060.8 KOO31388.1 - 0.069 12.7 1.2 0.98 9.0 0.2 3.2 2 1 1 3 3 3 0 Putative Fe-S cluster ZF-HD_dimer PF04770.7 KOO31388.1 - 0.23 11.5 1.5 24 5.0 0.0 2.5 2 0 0 2 2 2 0 ZF-HD protein dimerisation region DAP10 PF07213.6 KOO31388.1 - 9.6 6.0 7.1 15 5.4 0.1 3.1 2 1 1 3 3 3 0 DAP10 membrane protein PARP PF00644.15 KOO31389.1 - 2.5e-11 43.3 0.1 1.1e-10 41.3 0.1 2.0 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain YqaJ PF09588.5 KOO31391.1 - 2.2e-28 99.1 0.0 2.9e-28 98.7 0.0 1.2 1 0 0 1 1 1 1 YqaJ-like viral recombinase domain YIF1 PF03878.10 KOO31392.1 - 1.1e-57 194.9 0.1 1.4e-57 194.6 0.0 1.1 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.12 KOO31392.1 - 0.00018 21.0 9.5 0.00059 19.3 6.6 1.9 1 1 0 1 1 1 1 Yip1 domain GWT1 PF06423.7 KOO31392.1 - 0.1 12.6 0.6 0.29 11.2 0.1 2.0 2 0 0 2 2 2 0 GWT1 Chromate_transp PF02417.10 KOO31392.1 - 0.8 9.2 14.4 0.12 12.0 0.5 2.5 3 0 0 3 3 3 0 Chromate transporter Pkinase PF00069.20 KOO31393.1 - 6e-49 166.5 0.0 8.9e-49 165.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31393.1 - 9.2e-39 133.0 0.0 1.6e-38 132.3 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO31393.1 - 0.00018 20.6 0.0 0.00028 19.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like SKG6 PF08693.5 KOO31393.1 - 0.013 14.7 0.0 0.03 13.6 0.0 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain APH PF01636.18 KOO31393.1 - 0.017 14.8 0.2 0.11 12.1 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family SpoU_methylase PF00588.14 KOO31395.1 - 4.9e-25 88.0 0.0 7.2e-25 87.5 0.0 1.2 1 0 0 1 1 1 1 SpoU rRNA Methylase family FAD-oxidase_C PF02913.14 KOO31395.1 - 0.51 9.6 2.7 0.36 10.0 0.1 1.9 2 0 0 2 2 2 0 FAD linked oxidases, C-terminal domain Radial_spoke_3 PF06098.6 KOO31395.1 - 1.3 7.9 4.8 1.6 7.6 3.3 1.1 1 0 0 1 1 1 0 Radial spoke protein 3 TPT PF03151.11 KOO31396.1 - 5.1e-27 94.4 4.8 5.1e-27 94.4 3.3 2.5 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 KOO31396.1 - 3.1e-11 43.4 25.6 1.3e-08 34.8 4.8 2.8 1 1 2 3 3 3 2 EamA-like transporter family UAA PF08449.6 KOO31396.1 - 4.1e-09 35.8 11.2 7.2e-08 31.7 7.7 2.5 1 1 0 1 1 1 1 UAA transporter family Tom22 PF04281.8 KOO31396.1 - 0.19 11.2 1.7 6 6.3 0.2 2.5 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 WD40 PF00400.27 KOO31397.1 - 2.2e-66 217.5 22.0 4.2e-13 48.6 0.4 5.2 5 0 0 5 5 5 5 WD domain, G-beta repeat PD40 PF07676.7 KOO31397.1 - 2.1e-15 56.0 1.4 0.066 12.9 0.0 5.3 5 0 0 5 5 5 5 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOO31397.1 - 1.1e-09 38.3 0.6 1.9e-05 24.5 0.1 2.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.1 KOO31397.1 - 5.6e-06 25.6 2.4 0.73 8.8 0.0 4.1 1 1 4 5 5 5 3 Neuroblastoma-amplified sequence, N terminal DUF3312 PF11768.3 KOO31397.1 - 0.00022 19.6 0.0 1.1 7.3 0.0 3.3 1 1 3 4 4 4 2 Protein of unknown function (DUF3312) MMS1_N PF10433.4 KOO31397.1 - 0.0013 16.9 0.4 0.52 8.3 0.1 2.8 1 1 1 2 2 2 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term Gmad1 PF10647.4 KOO31397.1 - 0.0014 18.1 0.1 1.1 8.5 0.0 4.3 2 2 1 3 3 3 1 Lipoprotein LpqB beta-propeller domain DUF3892 PF13031.1 KOO31397.1 - 0.0071 16.7 0.9 0.32 11.4 0.0 2.9 2 1 1 3 3 3 1 Protein of unknown function (DUF3892) Nup160 PF11715.3 KOO31397.1 - 0.13 10.4 4.5 11 3.9 0.0 3.5 1 1 3 4 4 4 0 Nucleoporin Nup120/160 Dfp1_Him1_M PF08630.5 KOO31397.1 - 0.37 10.5 5.4 27 4.5 0.1 3.8 3 1 1 4 4 4 0 Dfp1/Him1, central region Proteasome_A_N PF10584.4 KOO31397.1 - 0.52 9.6 8.3 1.4e+02 1.8 0.1 5.3 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Carla_C4 PF01623.12 KOO31397.1 - 1 9.1 8.3 1.8 8.3 5.7 1.4 1 0 0 1 1 1 0 Carlavirus putative nucleic acid binding protein RHH_3 PF12651.2 KOO31397.1 - 3.2 7.5 7.1 31 4.4 0.1 3.9 4 0 0 4 4 4 0 Ribbon-helix-helix domain PPR_2 PF13041.1 KOO31398.1 - 9.5e-130 422.5 9.4 1.8e-14 53.4 0.0 13.2 1 1 11 13 13 13 13 PPR repeat family PPR_3 PF13812.1 KOO31398.1 - 2.2e-101 323.7 13.8 4.6e-08 32.7 0.0 14.4 14 0 0 14 14 14 14 Pentatricopeptide repeat domain PPR_1 PF12854.2 KOO31398.1 - 7.7e-101 329.2 7.5 3.4e-10 39.1 0.0 14.0 14 0 0 14 14 14 13 PPR repeat PPR PF01535.15 KOO31398.1 - 1.5e-95 306.7 7.2 5.7e-07 29.0 0.0 14.3 14 0 0 14 14 14 14 PPR repeat ECSIT PF06239.6 KOO31398.1 - 1.3e-11 43.8 0.0 3.1 6.6 0.0 9.0 2 1 8 10 10 10 3 Evolutionarily conserved signalling intermediate in Toll pathway Clathrin PF00637.15 KOO31398.1 - 3.6e-09 36.3 0.0 0.22 11.0 0.0 5.5 4 1 1 5 5 5 3 Region in Clathrin and VPS TPR_14 PF13428.1 KOO31398.1 - 9.4e-07 28.9 1.5 25 5.8 0.0 8.6 8 2 3 11 11 10 0 Tetratricopeptide repeat MRP-S27 PF10037.4 KOO31398.1 - 7.6e-06 25.1 0.1 0.31 9.8 0.0 4.4 3 1 2 5 5 5 2 Mitochondrial 28S ribosomal protein S27 Apc3 PF12895.2 KOO31398.1 - 0.0085 16.2 5.2 5.3 7.2 0.0 4.5 3 1 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 KOO31398.1 - 0.012 15.3 0.0 3.1 7.8 0.0 4.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 KOO31398.1 - 0.02 14.8 0.1 2 8.4 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat OmpA PF00691.15 KOO31398.1 - 0.027 14.8 0.8 1.8e+02 2.5 0.0 5.1 1 1 5 6 6 6 0 OmpA family TH1 PF04858.8 KOO31399.1 - 2.8e-37 128.1 0.3 9.3e-19 67.0 0.0 2.0 2 0 0 2 2 2 2 TH1 protein Glycogen_syn PF05693.8 KOO31399.1 - 0.084 11.0 0.0 0.12 10.5 0.0 1.1 1 0 0 1 1 1 0 Glycogen synthase Phage_lysis PF03245.8 KOO31400.1 - 5.4e-05 23.1 2.9 8.4e-05 22.5 2.0 1.3 1 0 0 1 1 1 1 Bacteriophage Rz lysis protein ATG16 PF08614.6 KOO31400.1 - 0.0025 17.6 0.6 0.0038 17.0 0.4 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Snapin_Pallidin PF14712.1 KOO31400.1 - 0.0067 16.7 0.3 0.0067 16.7 0.2 1.6 2 0 0 2 2 1 1 Snapin/Pallidin DLIC PF05783.6 KOO31400.1 - 0.0088 14.7 0.9 0.012 14.3 0.6 1.3 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) TMF_TATA_bd PF12325.3 KOO31400.1 - 0.014 15.1 3.3 0.023 14.4 2.3 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DASH_Spc19 PF08287.6 KOO31400.1 - 0.017 14.7 0.1 0.022 14.3 0.1 1.2 1 0 0 1 1 1 0 Spc19 Med4 PF10018.4 KOO31400.1 - 0.023 14.1 0.3 0.03 13.7 0.2 1.2 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 DivIC PF04977.10 KOO31400.1 - 0.028 13.8 0.3 0.052 13.0 0.2 1.4 1 0 0 1 1 1 0 Septum formation initiator FlxA PF14282.1 KOO31400.1 - 0.034 14.0 0.1 0.053 13.4 0.1 1.3 1 0 0 1 1 1 0 FlxA-like protein Prominin PF05478.6 KOO31400.1 - 0.037 11.5 2.2 0.1 10.1 0.1 1.9 2 0 0 2 2 2 0 Prominin Cluap1 PF10234.4 KOO31400.1 - 0.049 12.8 0.0 0.068 12.3 0.0 1.1 1 0 0 1 1 1 0 Clusterin-associated protein-1 OspD PF03207.8 KOO31400.1 - 0.081 12.0 0.4 0.1 11.7 0.3 1.1 1 0 0 1 1 1 0 Borrelia outer surface protein D (OspD) FlgN PF05130.7 KOO31400.1 - 0.1 12.8 3.0 0.15 12.3 2.1 1.2 1 0 0 1 1 1 0 FlgN protein DUF3138 PF11336.3 KOO31400.1 - 0.28 9.3 4.5 0.31 9.1 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Seryl_tRNA_N PF02403.17 KOO31400.1 - 0.61 10.1 3.7 1 9.3 2.6 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Carn_acyltransf PF00755.15 KOO31401.1 - 7.4e-140 466.8 0.0 5.1e-139 464.0 0.0 1.9 1 1 0 1 1 1 1 Choline/Carnitine o-acyltransferase Msg2_C PF12373.3 KOO31404.1 - 0.15 11.3 1.1 22 4.3 0.1 3.1 3 0 0 3 3 3 0 Major surface glycoprotein 2 C terminal PKD_channel PF08016.7 KOO31405.1 - 9.9e-26 90.1 17.5 6.2e-24 84.1 13.2 2.2 2 0 0 2 2 2 1 Polycystin cation channel EF-hand_1 PF00036.27 KOO31405.1 - 1.1e-09 36.8 0.3 0.00033 19.7 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO31405.1 - 2.5e-08 33.1 0.1 0.0013 18.4 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO31405.1 - 4.1e-07 30.0 0.1 9.7e-07 28.8 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO31405.1 - 8.1e-07 28.1 0.3 0.012 14.9 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO31405.1 - 1.5e-05 24.4 0.2 0.16 11.6 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.1 KOO31405.1 - 0.0011 18.8 0.0 0.0025 17.6 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.2 KOO31405.1 - 0.13 11.9 0.1 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Mon1 PF03164.9 KOO31406.1 - 1.2e-101 340.3 0.0 1.9e-101 339.7 0.0 1.2 1 0 0 1 1 1 1 Trafficking protein Mon1 ACT PF01842.20 KOO31406.1 - 1.4e-12 46.7 3.6 2.7e-08 33.1 0.2 3.0 2 1 1 3 3 3 2 ACT domain ACT_4 PF13291.1 KOO31406.1 - 1.6e-05 25.1 0.3 0.025 14.9 0.0 2.5 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.1 KOO31406.1 - 0.24 10.9 2.7 5.1 6.7 0.1 2.7 2 0 0 2 2 2 0 ACT domain DNA_ligase_A_M PF01068.16 KOO31407.1 - 3.6e-42 144.0 0.0 5.7e-42 143.3 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 KOO31407.1 - 2.2e-18 66.6 0.0 5.5e-17 62.1 0.0 2.3 1 1 0 1 1 1 1 DNA ligase N terminus zf-PARP PF00645.13 KOO31407.1 - 1.6e-15 57.0 0.0 3.3e-15 56.1 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region zf-CCHH PF10283.4 KOO31407.1 - 4.6e-11 42.3 2.5 9.3e-11 41.3 1.8 1.5 1 0 0 1 1 1 1 Zinc-finger (CX5CX6HX5H) motif DNA_ligase_A_C PF04679.10 KOO31407.1 - 3.7e-10 40.0 0.0 1.5e-09 38.1 0.0 2.1 1 1 0 1 1 1 1 ATP dependent DNA ligase C terminal region WWE PF02825.15 KOO31407.1 - 0.00016 20.9 0.0 0.0003 20.1 0.0 1.4 1 0 0 1 1 1 1 WWE domain mRNA_cap_enzyme PF01331.14 KOO31407.1 - 0.037 13.7 0.0 0.32 10.6 0.0 2.4 1 1 0 1 1 1 0 mRNA capping enzyme, catalytic domain PBP1_TM PF14812.1 KOO31407.1 - 1.8 8.9 11.9 4.1 7.7 3.8 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PAS_3 PF08447.6 KOO31408.1 - 5.7e-34 116.0 0.4 4.4e-09 36.3 0.0 4.9 5 0 0 5 5 5 4 PAS fold PAS_9 PF13426.1 KOO31408.1 - 2.5e-21 75.9 0.0 1.9e-05 24.9 0.0 4.5 4 1 0 4 4 4 3 PAS domain PAS_11 PF14598.1 KOO31408.1 - 5.3e-21 74.6 0.0 1.4e-05 24.9 0.0 4.5 4 0 0 4 4 4 4 PAS domain PAS PF00989.19 KOO31408.1 - 1.2e-18 66.9 0.0 0.00014 21.6 0.0 4.6 4 0 0 4 4 4 3 PAS fold PAS_4 PF08448.5 KOO31408.1 - 2.1e-15 56.7 0.3 0.00014 21.8 0.0 4.7 4 0 0 4 4 4 4 PAS fold AAA_5 PF07728.9 KOO31408.1 - 0.12 12.0 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SH3_6 PF12913.2 KOO31408.1 - 0.15 11.2 0.2 37 3.6 0.0 3.3 3 0 0 3 3 3 0 SH3 domain of the SH3b1 type Glyoxalase PF00903.20 KOO31409.1 - 4.6e-06 26.6 0.0 3.2e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.1 KOO31409.1 - 1.2e-05 25.3 0.0 0.029 14.3 0.0 2.7 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_5 PF14696.1 KOO31409.1 - 0.001 19.0 0.1 0.0087 15.9 0.0 2.2 2 0 0 2 2 2 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Glyoxalase_2 PF12681.2 KOO31409.1 - 0.0024 18.4 0.0 0.3 11.7 0.0 2.9 2 0 0 2 2 2 1 Glyoxalase-like domain Glyoxalase_3 PF13468.1 KOO31409.1 - 0.011 15.6 0.7 12 5.7 0.0 3.6 4 0 0 4 4 4 0 Glyoxalase-like domain TPT PF03151.11 KOO31410.1 - 5.8e-16 58.5 3.8 5.8e-16 58.5 2.7 2.0 2 0 0 2 2 2 1 Triose-phosphate Transporter family Methyltransf_21 PF05050.7 KOO31410.1 - 1.2e-07 31.7 0.0 2.5e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase FkbM domain EamA PF00892.15 KOO31410.1 - 1e-05 25.5 7.5 0.003 17.5 2.1 2.6 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.6 KOO31410.1 - 1.1e-05 24.5 8.2 1.7e-05 23.9 5.7 1.2 1 0 0 1 1 1 1 UAA transporter family Methyltransf_18 PF12847.2 KOO31410.1 - 0.00034 21.1 0.0 0.0015 19.0 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO31410.1 - 0.018 15.0 2.7 0.046 13.7 0.0 3.2 3 0 0 3 3 3 0 Methyltransferase domain Ion_trans PF00520.26 KOO31412.1 - 1.1e-07 31.3 7.0 2e-06 27.1 4.8 2.5 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.7 KOO31412.1 - 3.7e-05 22.3 1.9 7.5e-05 21.3 1.3 1.5 1 0 0 1 1 1 1 Polycystin cation channel GP46 PF07409.7 KOO31412.1 - 0.085 12.1 0.1 0.19 11.0 0.1 1.5 1 0 0 1 1 1 0 Phage protein GP46 SRPRB PF09439.5 KOO31413.1 - 5.9e-28 97.3 0.0 7.6e-28 96.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.16 KOO31413.1 - 5.6e-08 32.2 0.0 7.6e-08 31.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 KOO31413.1 - 2.3e-06 27.5 0.0 3.1e-05 23.8 0.0 2.2 1 1 1 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 KOO31413.1 - 0.00021 20.7 0.0 0.0045 16.4 0.0 2.2 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Miro PF08477.8 KOO31413.1 - 0.001 19.5 0.0 0.0075 16.7 0.0 2.0 2 0 0 2 2 2 1 Miro-like protein AAA_22 PF13401.1 KOO31413.1 - 0.019 15.1 0.0 0.06 13.4 0.0 1.8 1 1 1 2 2 2 0 AAA domain AAA_PrkA PF08298.6 KOO31413.1 - 0.054 12.1 0.0 0.078 11.6 0.0 1.2 1 0 0 1 1 1 0 PrkA AAA domain Abhydrolase_6 PF12697.2 KOO31415.1 - 2.5e-20 73.3 0.2 6.3e-20 72.0 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO31415.1 - 1.3e-15 57.3 0.0 4.4e-15 55.7 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 KOO31415.1 - 4.6e-11 42.4 1.7 1.9e-08 34.0 0.4 2.5 1 1 1 2 2 2 2 Putative lysophospholipase Abhydrolase_1 PF00561.15 KOO31415.1 - 1.3e-06 28.1 0.1 5.8e-06 26.0 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold E3_UbLigase_R4 PF13764.1 KOO31416.1 - 1.4e-170 568.9 0.0 2.6e-119 399.4 0.0 3.6 2 1 2 4 4 4 3 E3 ubiquitin-protein ligase UBR4 ZZ PF00569.12 KOO31416.1 - 8.6e-12 44.4 11.5 8.6e-12 44.4 8.0 3.6 3 0 0 3 3 3 2 Zinc finger, ZZ type TEX12 PF15219.1 KOO31416.1 - 0.11 12.4 0.1 0.29 11.1 0.1 1.6 1 0 0 1 1 1 0 Testis-expressed 12 PolC_DP2 PF03833.8 KOO31416.1 - 3.2 5.2 11.6 0.92 7.0 2.7 2.2 2 0 0 2 2 2 0 DNA polymerase II large subunit DP2 NUDIX PF00293.23 KOO31417.1 - 3e-09 36.6 0.1 1.1e-08 34.7 0.0 1.9 2 0 0 2 2 2 1 NUDIX domain Ion_trans PF00520.26 KOO31417.1 - 5e-08 32.4 3.3 1.8e-07 30.6 2.3 2.0 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.7 KOO31417.1 - 0.01 14.3 9.4 0.47 8.8 5.5 2.9 2 1 0 2 2 2 0 Polycystin cation channel Rib_hydrolayse PF02267.12 KOO31417.1 - 0.12 11.6 0.0 0.29 10.4 0.0 1.5 1 0 0 1 1 1 0 ADP-ribosyl cyclase HC2 PF07382.6 KOO31418.1 - 1.5 8.6 53.4 0.11 12.3 28.1 2.1 1 1 1 2 2 2 0 Histone H1-like nucleoprotein HC2 Glyco_hydro_31 PF01055.21 KOO31419.1 - 1.8e-138 462.1 0.2 9.4e-124 413.5 0.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 KOO31419.1 - 1.4e-17 63.2 0.1 4.8e-17 61.5 0.0 2.0 2 0 0 2 2 2 1 Galactose mutarotase-like Calreticulin PF00262.13 KOO31419.1 - 0.00064 18.4 0.4 0.00098 17.8 0.3 1.1 1 0 0 1 1 1 1 Calreticulin family PC-Esterase PF13839.1 KOO31420.1 - 2.6e-05 24.1 0.0 3.2e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p RCC1_2 PF13540.1 KOO31420.1 - 0.0074 15.8 0.1 0.027 14.0 0.1 2.0 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat Arm PF00514.18 KOO31421.1 - 2.4e-40 134.9 23.4 2.3e-09 36.7 0.0 9.9 10 0 0 10 10 10 6 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO31421.1 - 1.1e-23 83.2 13.4 2.6e-06 27.6 0.3 4.9 2 1 3 5 5 5 5 HEAT repeats HEAT PF02985.17 KOO31421.1 - 1.4e-17 62.1 12.6 0.00026 20.8 0.0 8.3 9 0 0 9 9 9 5 HEAT repeat HEAT_EZ PF13513.1 KOO31421.1 - 6.6e-14 51.9 25.6 0.00016 22.0 0.2 7.6 5 2 4 9 9 8 7 HEAT-like repeat Proteasom_PSMB PF10508.4 KOO31421.1 - 3e-12 45.6 0.1 2e-07 29.6 0.0 3.1 1 1 2 3 3 3 3 Proteasome non-ATPase 26S subunit Adaptin_N PF01602.15 KOO31421.1 - 6.3e-09 34.6 1.8 0.0014 17.0 0.4 3.6 2 1 1 3 3 3 3 Adaptin N terminal region DNA_alkylation PF08713.6 KOO31421.1 - 8.8e-08 31.9 0.0 0.56 9.6 0.0 3.8 3 1 0 3 3 3 3 DNA alkylation repair enzyme CLASP_N PF12348.3 KOO31421.1 - 6e-06 25.7 0.3 0.45 9.8 0.0 3.7 3 0 0 3 3 3 2 CLASP N terminal Cnd1 PF12717.2 KOO31421.1 - 2.6e-05 24.1 0.6 0.067 13.0 0.1 3.4 2 2 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Atx10homo_assoc PF09759.4 KOO31421.1 - 0.00059 19.5 0.3 0.91 9.2 0.1 3.5 3 1 1 4 4 4 1 Spinocerebellar ataxia type 10 protein domain RICTOR_V PF14668.1 KOO31421.1 - 0.0037 17.1 2.4 5.1 7.1 0.0 4.5 4 1 1 5 5 5 1 Rapamycin-insensitive companion of mTOR, domain 5 GatB_Yqey PF02637.13 KOO31421.1 - 0.0063 16.2 0.0 1 9.0 0.0 3.7 4 0 0 4 4 4 1 GatB domain DUF4343 PF14243.1 KOO31421.1 - 0.037 13.8 0.0 0.097 12.5 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4343) OHCU_decarbox PF09349.5 KOO31421.1 - 0.044 14.0 1.1 10 6.3 0.0 3.6 3 1 0 4 4 4 0 OHCU decarboxylase V-ATPase_H_C PF11698.3 KOO31421.1 - 0.056 13.3 0.1 23 4.9 0.1 3.9 3 1 1 4 4 4 0 V-ATPase subunit H API5 PF05918.6 KOO31421.1 - 0.056 11.9 0.2 2.8 6.3 0.0 2.8 2 1 2 4 4 4 0 Apoptosis inhibitory protein 5 (API5) HEAT_PBS PF03130.11 KOO31421.1 - 0.22 12.0 17.6 0.61 10.7 0.1 6.8 8 0 0 8 8 7 0 PBS lyase HEAT-like repeat DUF2274 PF10038.4 KOO31422.1 - 0.082 13.0 0.3 1.5 8.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2274) RPE65 PF03055.10 KOO31423.1 - 4.8e-66 223.2 0.0 2.5e-32 112.1 0.0 2.0 2 0 0 2 2 2 2 Retinal pigment epithelial membrane protein Cupin_3 PF05899.7 KOO31424.1 - 8.2e-07 28.3 1.3 0.00061 19.1 0.2 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF861) Cupin_2 PF07883.6 KOO31424.1 - 4.4e-05 22.9 0.0 0.14 11.6 0.0 2.3 2 0 0 2 2 2 2 Cupin domain EF-hand_1 PF00036.27 KOO31425.1 - 1.7e-25 86.2 3.3 6e-06 25.1 0.1 5.1 5 0 0 5 5 5 4 EF hand EF-hand_5 PF13202.1 KOO31425.1 - 3.5e-24 83.0 1.0 1.2e-05 24.3 0.0 5.1 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO31425.1 - 2.3e-23 79.8 0.6 7.2e-05 22.3 0.0 5.0 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO31425.1 - 3.8e-21 74.9 0.4 2.3e-10 40.4 0.0 4.4 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO31425.1 - 1.2e-13 50.4 1.1 1.6e-05 24.4 0.0 5.0 3 1 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO31425.1 - 0.00013 21.9 1.5 0.00053 19.9 0.0 2.7 4 0 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region DUF1471 PF07338.8 KOO31425.1 - 0.55 9.9 4.0 6.3 6.5 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1471) RepB PF07506.6 KOO31426.1 - 0.055 13.3 0.1 0.075 12.9 0.0 1.1 1 0 0 1 1 1 0 RepB plasmid partitioning protein FA_desaturase PF00487.19 KOO31427.1 - 6.3e-31 107.7 10.2 1.4e-30 106.5 7.1 1.6 1 1 0 1 1 1 1 Fatty acid desaturase EF-hand_6 PF13405.1 KOO31429.1 - 2.4e-08 33.1 0.7 0.0031 17.2 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO31429.1 - 5.9e-07 29.5 0.0 1e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO31429.1 - 4.9e-06 25.4 0.0 0.013 14.7 0.0 2.5 2 0 0 2 2 2 2 EF hand PGBA_C PF15437.1 KOO31429.1 - 0.00038 20.5 11.3 0.00038 20.5 7.9 2.7 3 0 0 3 3 3 1 Plasminogen-binding protein pgbA C-terminal EF-hand_5 PF13202.1 KOO31429.1 - 0.0044 16.3 0.0 0.77 9.2 0.0 2.6 2 0 0 2 2 2 1 EF hand DUF1168 PF06658.7 KOO31429.1 - 0.96 8.9 23.5 0.079 12.4 7.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) BTV_NS2 PF04514.7 KOO31429.1 - 2.1 7.1 13.6 2.2 7.0 1.4 2.2 2 0 0 2 2 2 0 Bluetongue virus non-structural protein NS2 SR-25 PF10500.4 KOO31429.1 - 3.5 7.0 24.3 0.26 10.7 6.3 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein NARP1 PF12569.3 KOO31429.1 - 4.7 5.8 19.2 1.3 7.7 7.3 2.2 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 RNase_H2-Ydr279 PF09468.5 KOO31429.1 - 5 6.2 18.1 5.9 5.9 1.2 2.1 2 0 0 2 2 2 0 Ydr279p protein family (RNase H2 complex component) TFIIF_alpha PF05793.7 KOO31429.1 - 5.2 5.3 29.2 0.84 7.9 5.8 2.1 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Peptidase_S49_N PF08496.5 KOO31429.1 - 8.2 6.2 16.3 11 5.7 0.7 2.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF2828 PF11443.3 KOO31429.1 - 8.2 4.4 9.6 0.61 8.2 2.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) Lon_C PF05362.8 KOO31430.1 - 8.6e-75 250.5 2.8 1.1e-74 250.1 1.0 1.9 2 1 0 2 2 2 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.24 KOO31430.1 - 2e-22 79.8 0.0 4e-22 78.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KOO31430.1 - 1.4e-09 37.8 0.0 2.6e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.1 KOO31430.1 - 1.5e-07 30.9 0.1 2.3e-06 27.1 0.0 2.5 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase AAA_PrkA PF08298.6 KOO31430.1 - 1.1e-06 27.6 0.0 1.7e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain AAA_16 PF13191.1 KOO31430.1 - 2.2e-05 24.5 1.2 0.00052 20.0 0.0 2.9 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.7 KOO31430.1 - 6.2e-05 22.1 0.0 0.00033 19.7 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 KOO31430.1 - 6.8e-05 22.8 0.0 0.002 18.0 0.0 2.6 2 1 1 3 3 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 KOO31430.1 - 0.00012 22.2 0.0 0.0023 18.0 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.1 KOO31430.1 - 0.0037 16.8 0.0 0.0072 15.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.6 KOO31430.1 - 0.0058 16.2 0.0 0.016 14.7 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.12 KOO31430.1 - 0.01 15.2 0.0 0.02 14.2 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_17 PF13207.1 KOO31430.1 - 0.011 16.5 0.0 0.025 15.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 KOO31430.1 - 0.014 14.5 0.0 0.032 13.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 NTPase_1 PF03266.10 KOO31430.1 - 0.017 14.8 0.0 0.26 10.9 0.0 2.3 1 1 1 2 2 2 0 NTPase NACHT PF05729.7 KOO31430.1 - 0.038 13.6 0.0 0.13 11.8 0.0 1.9 2 0 0 2 2 2 0 NACHT domain Birna_VP4 PF01768.11 KOO31430.1 - 0.043 12.8 0.1 0.043 12.8 0.1 2.7 3 0 0 3 3 3 0 Birnavirus VP4 protein AAA_33 PF13671.1 KOO31430.1 - 0.056 13.3 0.2 0.14 12.0 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_14 PF13173.1 KOO31430.1 - 0.057 13.3 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain OMPdecase PF00215.19 KOO31430.1 - 0.076 12.4 0.5 0.12 11.7 0.4 1.2 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family Arch_ATPase PF01637.13 KOO31430.1 - 0.14 11.7 0.0 6.7 6.3 0.0 2.2 1 1 1 2 2 2 0 Archaeal ATPase RNA_helicase PF00910.17 KOO31430.1 - 0.18 12.0 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 RNA helicase PUB PF09409.5 KOO31431.1 - 9.6e-07 28.4 0.0 1.4e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 PUB domain DnaJ PF00226.26 KOO31432.1 - 5.6e-19 67.6 1.7 1.1e-18 66.6 1.2 1.5 1 0 0 1 1 1 1 DnaJ domain DUF1977 PF09320.6 KOO31432.1 - 4.2e-17 62.3 0.0 1.1e-16 61.0 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1977) DUF4237 PF14021.1 KOO31433.1 - 0.072 13.3 0.0 0.21 11.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4237) MORN PF02493.15 KOO31434.1 - 0.018 14.7 1.0 0.59 9.9 0.0 3.3 2 1 1 3 3 3 0 MORN repeat DUF4006 PF13179.1 KOO31434.1 - 1.4 8.5 3.9 2.9 7.5 2.7 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF4006) DUF4133 PF13571.1 KOO31434.1 - 1.9 8.7 5.5 0.4 10.9 1.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4133) DUF3985 PF13153.1 KOO31434.1 - 3.8 7.4 8.8 18 5.2 3.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3985) FHA PF00498.21 KOO31435.1 - 5.2e-14 52.1 0.0 8.4e-14 51.4 0.0 1.3 1 0 0 1 1 1 1 FHA domain PTCB-BRCT PF12738.2 KOO31435.1 - 7.6e-08 32.1 0.0 1.2e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.21 KOO31435.1 - 0.067 13.3 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain DUF221 PF02714.10 KOO31436.1 - 9.1e-07 28.0 3.2 0.013 14.3 0.1 3.1 2 1 0 2 2 2 2 Domain of unknown function DUF221 Anoctamin PF04547.7 KOO31436.1 - 1.4e-05 23.9 0.0 3.1e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Calcium-activated chloride channel SHMT PF00464.14 KOO31437.1 - 1.2e-202 672.6 0.0 1.4e-202 672.4 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.16 KOO31437.1 - 3.2e-07 29.7 0.0 4.7e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase PaaB PF06243.6 KOO31438.1 - 0.14 12.3 0.0 2.3 8.4 0.0 2.1 1 1 1 2 2 2 0 Phenylacetic acid degradation B Ank_2 PF12796.2 KOO31439.1 - 0.00046 20.4 0.5 0.0014 18.9 0.2 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO31439.1 - 0.0071 16.8 0.0 0.02 15.4 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO31439.1 - 0.021 15.0 0.1 8.7 6.9 0.0 3.6 3 0 0 3 3 3 0 Ankyrin repeat Ank_5 PF13857.1 KOO31439.1 - 0.097 12.9 0.2 0.84 9.9 0.1 2.7 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Ank PF00023.25 KOO31439.1 - 0.14 12.0 0.3 4.5 7.2 0.1 2.6 2 0 0 2 2 2 0 Ankyrin repeat Reo_sigmaC PF04582.7 KOO31440.1 - 0.1 11.7 3.6 0.27 10.3 2.5 1.7 1 1 0 1 1 1 0 Reovirus sigma C capsid protein Spc7 PF08317.6 KOO31440.1 - 0.16 10.5 7.8 0.074 11.7 3.7 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein Mitofilin PF09731.4 KOO31440.1 - 0.49 8.9 32.4 0.59 8.7 22.5 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein AAA_13 PF13166.1 KOO31440.1 - 0.7 8.2 13.4 1.4 7.2 9.0 1.7 1 1 0 1 1 1 0 AAA domain BTV_NS2 PF04514.7 KOO31440.1 - 0.83 8.4 8.2 1.5 7.6 5.7 1.4 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 TMCO5 PF14992.1 KOO31440.1 - 3.1 6.8 6.9 5.7 5.9 4.8 1.4 1 0 0 1 1 1 0 TMCO5 family DUF1395 PF07160.7 KOO31440.1 - 8.7 5.7 11.5 3.1 7.2 4.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1395) Ded_cyto PF06920.8 KOO31441.1 - 0.0036 16.6 0.3 0.0084 15.4 0.2 1.6 1 0 0 1 1 1 1 Dedicator of cytokinesis GLE1 PF07817.8 KOO31441.1 - 0.0038 16.1 2.1 0.0071 15.3 1.5 1.4 1 0 0 1 1 1 1 GLE1-like protein Lipase_GDSL_2 PF13472.1 KOO31443.1 - 3.3e-13 50.1 0.1 6.8e-13 49.1 0.0 1.6 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family HATPase_c_3 PF13589.1 KOO31444.1 - 1.5e-08 34.3 0.0 8.3e-08 31.9 0.0 1.9 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 KOO31444.1 - 0.055 13.1 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SQS_PSY PF00494.14 KOO31446.1 - 0.077 12.2 0.1 0.079 12.2 0.0 1.1 1 0 0 1 1 1 0 Squalene/phytoene synthase DUF3860 PF12976.2 KOO31447.1 - 0.027 14.2 3.3 31 4.4 0.0 4.5 5 0 0 5 5 5 0 Domain of Unknown Function with PDB structure (DUF3860) WGG PF10273.4 KOO31447.1 - 0.027 14.5 0.2 65 3.7 0.0 4.5 5 0 0 5 5 5 0 Pre-rRNA-processing protein TSR2 Ribosomal_S13_N PF08069.7 KOO31447.1 - 0.2 11.5 14.7 18 5.2 0.1 5.8 6 0 0 6 6 6 0 Ribosomal S13/S15 N-terminal domain Phage_GPL PF05926.6 KOO31447.1 - 0.98 9.2 4.7 9.6 6.0 0.2 3.4 3 0 0 3 3 3 0 Phage head completion protein (GPL) PPP1R35_C PF15503.1 KOO31447.1 - 1.3 8.5 22.3 3.8 7.0 0.1 5.2 5 0 0 5 5 5 0 Protein phosphatase 1 regulatory subunit 35 C-terminus PhyH PF05721.8 KOO31448.1 - 5e-05 23.4 0.1 7.5e-05 22.8 0.1 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DEAD PF00270.24 KOO31451.1 - 3e-17 62.6 0.0 5.9e-16 58.4 0.0 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO31451.1 - 1.5e-06 27.9 0.0 3.1e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Glycos_trans_3N PF02885.12 KOO31451.1 - 0.0086 15.6 2.9 0.13 11.8 0.1 2.5 2 0 0 2 2 2 1 Glycosyl transferase family, helical bundle domain ResIII PF04851.10 KOO31451.1 - 0.065 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit PTPlike_phytase PF14566.1 KOO31451.1 - 0.078 13.0 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate Pam16 PF03656.8 KOO31451.1 - 0.57 9.9 2.2 0.83 9.4 0.1 2.2 2 0 0 2 2 2 0 Pam16 bPH_6 PF10756.4 KOO31452.1 - 0.031 14.1 0.1 4.9 7.1 0.0 2.5 2 0 0 2 2 2 0 Bacterial PH domain TruB_C PF09142.6 KOO31452.1 - 0.067 12.8 0.3 0.21 11.2 0.1 1.9 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal DAP_C PF07932.7 KOO31454.1 - 0.1 12.7 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 D-aminopeptidase, domain C zf-C3HC4_3 PF13920.1 KOO31455.1 - 2.3e-05 23.9 2.2 0.00011 21.8 1.6 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO31455.1 - 0.00088 19.2 1.2 0.00088 19.2 0.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DUF393 PF04134.7 KOO31455.1 - 0.019 16.0 3.4 0.055 14.5 1.6 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF393 Transglycosylas PF06737.9 KOO31455.1 - 0.26 11.5 2.2 0.37 11.1 0.0 2.4 2 0 0 2 2 2 0 Transglycosylase-like domain zf-RING_4 PF14570.1 KOO31455.1 - 6.2 6.4 7.4 1.4 8.5 1.3 2.8 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain DUF1336 PF07059.7 KOO31457.1 - 0.044 13.2 0.0 0.07 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1336) NYD-SP12_N PF15015.1 KOO31457.1 - 0.055 11.7 0.7 0.075 11.2 0.5 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated, N-terminal Aa_trans PF01490.13 KOO31458.1 - 2.3e-21 75.7 13.1 1.1e-17 63.7 2.2 2.1 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein Glucosamine_iso PF01182.15 KOO31459.1 - 2.9e-28 98.9 0.1 4e-28 98.5 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Activator_LAG-3 PF11498.3 KOO31461.1 - 0.073 11.8 12.4 0.11 11.2 8.6 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Dzip-like_N PF13815.1 KOO31461.1 - 0.13 12.1 6.3 0.21 11.4 4.4 1.2 1 0 0 1 1 1 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal SNF2_N PF00176.18 KOO31463.1 - 6.3e-64 215.6 0.0 8.4e-64 215.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOO31463.1 - 3.5e-14 52.4 0.0 2e-13 50.0 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 KOO31463.1 - 8e-09 34.7 0.0 2.5e-08 33.1 0.0 1.7 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.24 KOO31463.1 - 9.3e-07 28.4 0.0 1.5e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase PHD PF00628.24 KOO31463.1 - 3.2e-05 23.5 4.6 0.0006 19.4 0.0 2.5 2 0 0 2 2 2 1 PHD-finger zf-PHD-like PF15446.1 KOO31463.1 - 0.013 14.7 1.0 0.18 11.0 0.1 2.3 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain NOA36 PF06524.7 KOO31463.1 - 6.2 5.9 10.2 11 5.2 7.1 1.3 1 0 0 1 1 1 0 NOA36 protein DUF3337 PF11816.3 KOO31464.1 - 0.00034 20.1 0.0 0.00049 19.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) DUF2237 PF09996.4 KOO31464.1 - 0.16 11.4 0.0 0.26 10.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2237) G-alpha PF00503.15 KOO31465.1 - 2e-109 365.8 1.6 2.3e-109 365.6 1.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 KOO31465.1 - 8.1e-17 61.0 0.6 2.2e-14 53.0 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KOO31465.1 - 1.4e-05 24.3 3.3 0.00052 19.2 1.1 2.5 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region Miro PF08477.8 KOO31465.1 - 0.015 15.7 0.3 2 8.9 0.0 2.7 2 0 0 2 2 2 0 Miro-like protein AAA_29 PF13555.1 KOO31465.1 - 0.15 11.6 0.1 0.31 10.5 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF544 PF04424.8 KOO31466.1 - 2.8e-30 104.6 0.2 4.7e-30 103.8 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF544) LRR_6 PF13516.1 KOO31467.1 - 1.5e-22 77.1 12.6 0.052 13.6 0.0 11.1 11 0 0 11 11 11 8 Leucine Rich repeat LRR_1 PF00560.28 KOO31467.1 - 8.4e-11 40.3 0.7 6.3 7.2 0.0 8.0 9 0 0 9 9 9 2 Leucine Rich Repeat LRR_4 PF12799.2 KOO31467.1 - 6e-08 32.1 11.7 0.29 10.8 0.0 6.6 4 2 1 6 6 6 4 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO31467.1 - 2.3e-05 23.8 7.0 43 4.9 0.0 7.9 7 0 0 7 7 7 0 Leucine rich repeat Skp1 PF01466.14 KOO31467.1 - 0.00056 19.8 0.0 0.0019 18.2 0.0 1.9 1 0 0 1 1 1 1 Skp1 family, dimerisation domain SpoU_sub_bind PF08032.7 KOO31467.1 - 0.0065 16.6 0.3 41 4.4 0.0 4.1 4 0 0 4 4 4 0 RNA 2'-O ribose methyltransferase substrate binding TPR_12 PF13424.1 KOO31469.1 - 0.00012 21.9 8.1 0.0007 19.4 0.3 4.4 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO31469.1 - 0.0019 17.7 2.2 0.01 15.4 0.0 3.3 3 0 0 3 3 3 1 TPR repeat TPR_2 PF07719.12 KOO31469.1 - 0.0029 17.3 3.8 5.8 7.0 0.1 5.2 6 0 0 6 6 6 2 Tetratricopeptide repeat SNAP PF14938.1 KOO31469.1 - 0.036 13.2 0.0 0.087 11.9 0.0 1.6 2 0 0 2 2 2 0 Soluble NSF attachment protein, SNAP HemY_N PF07219.8 KOO31469.1 - 0.37 10.3 5.0 1.7 8.2 0.0 3.4 3 0 0 3 3 3 0 HemY protein N-terminus ERGIC_N PF13850.1 KOO31471.1 - 0.032 14.2 0.5 0.34 10.9 0.0 2.7 3 0 0 3 3 3 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Claudin_3 PF06653.6 KOO31471.1 - 0.055 13.1 4.8 0.043 13.5 0.5 2.4 1 1 1 2 2 2 0 Tight junction protein, Claudin-like Chordopox_G2 PF05796.7 KOO31471.1 - 0.088 11.9 0.0 0.21 10.6 0.0 1.5 1 1 0 1 1 1 0 Chordopoxvirus protein G2 DUF4234 PF14018.1 KOO31471.1 - 0.22 11.2 3.3 6.9 6.4 0.1 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4234) PsbN PF02468.10 KOO31471.1 - 0.38 10.4 2.1 0.6 9.7 0.2 2.2 2 0 0 2 2 2 0 Photosystem II reaction centre N protein (psbN) Cation_efflux PF01545.16 KOO31471.1 - 1.8 7.5 7.9 8.7 5.3 5.2 2.1 1 1 0 1 1 1 0 Cation efflux family Arm PF00514.18 KOO31472.1 - 4.6e-28 96.0 19.0 8e-08 31.8 0.2 6.0 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat Rep-A_N PF04057.7 KOO31472.1 - 3.9e-27 93.9 2.5 7.6e-27 93.0 1.7 1.5 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain HEAT PF02985.17 KOO31472.1 - 0.00041 20.2 4.9 12 6.3 0.0 6.1 6 0 0 6 6 6 1 HEAT repeat HEAT_2 PF13646.1 KOO31472.1 - 0.002 18.3 37.1 1.3 9.3 6.6 4.3 1 1 3 4 4 4 4 HEAT repeats DUF1869 PF08956.5 KOO31472.1 - 0.024 14.2 0.5 76 3.0 0.0 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF1869) CheW PF01584.14 KOO31472.1 - 0.082 12.3 0.1 0.15 11.5 0.1 1.4 1 0 0 1 1 1 0 CheW-like domain Succ_CoA_lig PF13607.1 KOO31472.1 - 0.092 12.3 20.0 0.83 9.2 1.8 3.9 2 1 2 4 4 4 0 Succinyl-CoA ligase like flavodoxin domain Mg_trans_NIPA PF05653.9 KOO31473.1 - 2.5e-06 26.6 18.2 9.6e-06 24.7 0.7 2.7 3 0 0 3 3 3 2 Magnesium transporter NIPA SHOCT PF09851.4 KOO31473.1 - 0.0012 18.2 0.5 0.0022 17.3 0.3 1.5 1 0 0 1 1 1 1 Short C-terminal domain DUF910 PF06014.6 KOO31473.1 - 0.089 12.7 0.1 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF910) Cas_Cas2CT1978 PF09707.5 KOO31474.1 - 0.084 12.8 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas2CT1978) DUF4005 PF13178.1 KOO31474.1 - 0.23 11.6 9.4 0.039 14.1 3.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4005) GATase_6 PF13522.1 KOO31475.1 - 0.015 15.2 0.2 0.029 14.3 0.1 1.4 1 0 0 1 1 1 0 Glutamine amidotransferase domain Snf7 PF03357.16 KOO31476.1 - 8e-36 122.9 26.9 8.9e-36 122.8 18.6 1.0 1 0 0 1 1 1 1 Snf7 Ist1 PF03398.9 KOO31476.1 - 0.0014 18.0 3.2 0.0018 17.6 2.2 1.3 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway T2SM_b PF10741.4 KOO31476.1 - 0.028 14.0 0.2 0.058 13.0 0.1 1.5 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M subtype b Pox_A_type_inc PF04508.7 KOO31476.1 - 0.062 13.0 3.4 3 7.8 3.2 2.6 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat 3HCDH_N PF02737.13 KOO31476.1 - 1.1 8.8 6.0 3.1 7.4 3.6 1.8 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain YlqD PF11068.3 KOO31476.1 - 1.2 9.1 14.4 0.55 10.2 3.8 2.1 1 1 1 2 2 2 0 YlqD protein Viral_P18 PF04521.8 KOO31476.1 - 1.3 8.4 6.9 0.66 9.4 1.1 2.2 1 1 1 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein CENP-Q PF13094.1 KOO31476.1 - 2.4 8.1 10.5 5.1 7.0 7.2 1.6 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit RPW8 PF05659.6 KOO31476.1 - 3 7.3 10.6 2.8 7.4 6.6 1.5 1 1 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF972 PF06156.8 KOO31476.1 - 3.9 7.8 13.0 0.72 10.2 2.3 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF972) CENP-H PF05837.7 KOO31476.1 - 6 7.0 15.7 7.2 6.8 0.7 2.6 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DNA_pol_B PF00136.16 KOO31477.1 - 8.7e-48 163.2 0.0 1.2e-47 162.8 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B zf-C4pol PF14260.1 KOO31477.1 - 7.6e-12 45.0 5.3 1.6e-11 44.0 3.7 1.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta Pro_isomerase PF00160.16 KOO31478.1 - 2.1e-41 141.6 0.1 2.3e-41 141.5 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DNA_pol_B PF00136.16 KOO31480.1 - 3.9e-17 62.1 0.0 5e-17 61.8 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 KOO31480.1 - 2.1e-07 30.1 0.0 3.1e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain Gly-zipper_OmpA PF13436.1 KOO31480.1 - 0.15 11.7 4.3 0.28 10.8 3.0 1.4 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Bacteriocin_IIc PF10439.4 KOO31480.1 - 1.9 8.6 16.6 3.9 7.6 11.5 1.5 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Ion_trans PF00520.26 KOO31481.1 - 7.3e-70 234.2 12.4 2.5e-37 128.0 9.2 2.9 2 1 0 2 2 2 2 Ion transport protein Ion_trans PF00520.26 KOO31482.1 - 1.3e-12 47.4 1.0 1.3e-12 47.4 0.7 1.3 2 0 0 2 2 2 1 Ion transport protein PKD_channel PF08016.7 KOO31482.1 - 0.012 14.0 0.6 0.014 13.8 0.4 1.0 1 0 0 1 1 1 0 Polycystin cation channel Ion_trans_2 PF07885.11 KOO31484.1 - 1.2e-14 53.7 12.3 2.3e-09 36.8 1.0 3.6 4 0 0 4 4 4 2 Ion channel HPP PF04982.8 KOO31484.1 - 0.11 12.3 7.0 0.73 9.6 1.6 2.9 2 0 0 2 2 2 0 HPP family DUF1680 PF07944.7 KOO31485.1 - 2e-07 29.6 0.0 0.00036 18.9 0.0 3.0 3 0 0 3 3 3 3 Putative glycosyl hydrolase of unknown function (DUF1680) Ion_trans_2 PF07885.11 KOO31486.1 - 2.4e-22 78.4 8.4 1.6e-11 43.7 0.1 2.8 2 0 0 2 2 2 2 Ion channel PMP22_Claudin PF00822.15 KOO31486.1 - 0.037 13.6 0.0 0.11 12.1 0.0 1.8 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family PPR_2 PF13041.1 KOO31487.1 - 9.6e-94 307.2 11.8 7.5e-15 54.6 0.0 11.9 3 2 9 12 12 12 11 PPR repeat family PPR PF01535.15 KOO31487.1 - 4.8e-71 229.9 6.3 2.5e-07 30.2 0.0 12.7 12 0 0 12 12 12 12 PPR repeat PPR_3 PF13812.1 KOO31487.1 - 3.8e-70 226.3 14.0 9.3e-07 28.6 0.0 13.9 14 0 0 14 14 14 12 Pentatricopeptide repeat domain PPR_1 PF12854.2 KOO31487.1 - 7e-67 220.5 5.3 1.9e-08 33.6 0.0 12.8 13 0 0 13 13 13 10 PPR repeat ECSIT PF06239.6 KOO31487.1 - 1.7e-06 27.0 0.0 5.2 5.8 0.1 6.0 5 1 2 7 7 7 1 Evolutionarily conserved signalling intermediate in Toll pathway Clathrin PF00637.15 KOO31487.1 - 7.9e-06 25.5 0.0 1.5 8.4 0.0 4.4 3 2 1 4 4 4 2 Region in Clathrin and VPS TPR_14 PF13428.1 KOO31487.1 - 0.0003 21.1 7.5 4.6 8.1 0.1 7.2 8 0 0 8 8 7 1 Tetratricopeptide repeat Apc3 PF12895.2 KOO31487.1 - 0.0015 18.6 4.1 0.42 10.7 0.2 4.2 3 2 2 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 KOO31487.1 - 0.0021 17.7 0.0 23 5.1 0.1 4.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Sda PF08970.5 KOO31487.1 - 0.014 14.9 1.3 47 3.5 0.0 5.0 5 0 0 5 5 5 0 Sporulation inhibitor A MRP-S27 PF10037.4 KOO31487.1 - 0.016 14.1 0.1 9 5.0 0.0 3.4 1 1 3 4 4 4 0 Mitochondrial 28S ribosomal protein S27 MlrC_C PF07171.7 KOO31487.1 - 0.023 14.2 0.2 0.043 13.3 0.1 1.3 1 0 0 1 1 1 0 MlrC C-terminus TPR_19 PF14559.1 KOO31487.1 - 0.033 14.5 11.7 0.085 13.2 0.1 5.8 6 2 2 8 8 7 0 Tetratricopeptide repeat ATP13 PF12921.2 KOO31487.1 - 0.09 12.1 0.0 2.9 7.2 0.0 3.4 3 1 0 3 3 3 0 Mitochondrial ATPase expression COX5A PF02284.11 KOO31487.1 - 0.12 12.3 0.4 84 3.1 0.0 4.2 4 2 2 6 6 6 0 Cytochrome c oxidase subunit Va POR PF01558.13 KOO31488.1 - 0.0072 16.2 0.0 0.0094 15.8 0.0 1.1 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase DUF1275 PF06912.6 KOO31489.1 - 2.8e-28 98.5 11.5 4.8e-28 97.7 8.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1275) Trep_Strep PF09605.5 KOO31489.1 - 0.017 14.7 0.5 0.017 14.7 0.3 2.8 2 1 0 2 2 2 0 Hypothetical bacterial integral membrane protein (Trep_Strep) PMP22_Claudin PF00822.15 KOO31489.1 - 0.023 14.3 0.9 0.15 11.7 0.4 2.1 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin family DUF4131 PF13567.1 KOO31489.1 - 0.1 12.0 3.9 1.8 7.9 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Tetraspannin PF00335.15 KOO31489.1 - 9.4 5.4 9.8 29 3.8 0.1 3.0 2 1 0 2 2 2 0 Tetraspanin family DUF3446 PF11928.3 KOO31490.1 - 1.1 9.4 3.6 2.2 8.5 2.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3446) DUF4613 PF15390.1 KOO31490.1 - 3.5 5.6 12.3 5.8 4.9 8.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) DUF1499 PF07386.6 KOO31492.1 - 1.5e-08 34.8 0.1 5.1e-08 33.1 0.1 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1499) Lipase_GDSL_2 PF13472.1 KOO31493.1 - 3.1e-05 24.1 0.9 0.23 11.5 0.0 3.0 3 0 0 3 3 3 2 GDSL-like Lipase/Acylhydrolase family Beach PF02138.13 KOO31494.1 - 3.2e-85 285.8 0.0 4.4e-85 285.3 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.1 KOO31494.1 - 1.1e-07 31.6 0.2 3.7e-06 26.7 0.0 2.6 2 1 0 2 2 2 1 PH domain associated with Beige/BEACH Romo1 PF10247.4 KOO31494.1 - 0.061 13.5 0.6 0.12 12.5 0.4 1.4 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 Pro_isomerase PF00160.16 KOO31495.1 - 5.7e-22 78.5 0.1 6.5e-22 78.4 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD MMR_HSR1 PF01926.18 KOO31498.1 - 6.2e-06 26.1 0.0 1.7e-05 24.7 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase Ras PF00071.17 KOO31498.1 - 0.023 14.0 0.0 2.4 7.5 0.0 2.2 2 0 0 2 2 2 0 Ras family Miro PF08477.8 KOO31498.1 - 0.034 14.6 0.0 1.2 9.6 0.0 2.2 2 0 0 2 2 2 0 Miro-like protein DUF3297 PF11730.3 KOO31498.1 - 0.076 12.7 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3297) FlgN PF05130.7 KOO31499.1 - 0.00049 20.3 10.0 0.00049 20.3 6.9 1.5 1 1 1 2 2 2 1 FlgN protein GHMP_kinases_C PF08544.8 KOO31499.1 - 0.015 15.5 0.4 0.035 14.2 0.1 1.9 1 1 0 1 1 1 0 GHMP kinases C terminal DUF3005 PF11448.3 KOO31499.1 - 0.019 14.5 0.1 0.031 13.8 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3005) REV PF00424.13 KOO31499.1 - 0.025 14.4 0.8 0.045 13.6 0.5 1.4 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) DUF1485 PF07364.7 KOO31499.1 - 0.039 13.1 0.9 0.052 12.7 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1485) Med4 PF10018.4 KOO31499.1 - 0.52 9.6 4.3 0.55 9.6 2.3 1.6 1 1 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 ING PF12998.2 KOO31499.1 - 0.82 9.9 3.9 12 6.2 2.7 2.2 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding HR1 PF02185.11 KOO31499.1 - 4.7 7.0 7.5 43 3.9 5.2 2.3 1 1 0 1 1 1 0 Hr1 repeat SART-1 PF03343.8 KOO31500.1 - 0.021 13.1 12.9 0.023 13.0 9.0 1.0 1 0 0 1 1 1 0 SART-1 family DUF2058 PF09831.4 KOO31500.1 - 2.3 8.0 19.0 2.3 8.0 13.2 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) Rtf2 PF04641.7 KOO31500.1 - 4.8 6.3 19.6 5 6.2 13.6 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger Methyltransf_18 PF12847.2 KOO31501.1 - 9.9e-06 26.1 0.0 1.4e-05 25.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO31501.1 - 0.00013 22.0 0.1 0.00019 21.4 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO31501.1 - 0.0018 18.0 0.0 0.0034 17.1 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO31501.1 - 0.0042 17.5 0.0 0.0074 16.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO31501.1 - 0.012 15.9 0.0 0.018 15.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 KOO31501.1 - 0.022 14.3 0.1 0.042 13.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain C2 PF00168.25 KOO31502.1 - 1e-70 233.5 0.0 1.2e-18 66.6 0.0 6.4 5 1 1 6 6 6 6 C2 domain Glyco_hydro_3 PF00933.16 KOO31503.1 - 1.5e-53 181.7 0.0 2.3e-53 181.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 KOO31503.1 - 1.1e-34 119.9 0.0 1.9e-34 119.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 KOO31503.1 - 5.6e-06 26.2 0.0 1e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain CS PF04969.11 KOO31504.1 - 4.6e-06 27.0 0.1 6.8e-06 26.5 0.1 1.3 1 0 0 1 1 1 1 CS domain DUF995 PF06191.7 KOO31504.1 - 0.087 12.2 0.0 0.087 12.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF995) GCC2_GCC3 PF07699.8 KOO31505.1 - 6.5e-28 96.0 128.4 2.7e-07 30.0 0.5 16.2 7 4 7 15 15 15 7 GCC2 and GCC3 VCBS PF13517.1 KOO31505.1 - 2.3e-20 72.7 13.9 9.9e-13 48.2 4.0 2.7 1 1 1 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO31505.1 - 8.8e-15 53.9 25.9 4.4e-05 23.0 3.0 3.7 3 0 0 3 3 3 3 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO31505.1 - 0.00063 19.2 6.8 1.9 7.9 0.1 3.3 1 1 2 3 3 3 3 Insecticide toxin TcdB middle/N-terminal region NCD3G PF07562.9 KOO31505.1 - 0.012 15.3 1.3 0.012 15.3 0.9 12.0 11 4 3 14 14 14 0 Nine Cysteines Domain of family 3 GPCR TRP PF06011.7 KOO31505.1 - 0.068 11.7 4.7 0.16 10.4 3.3 1.5 1 1 0 1 1 1 0 Transient receptor potential (TRP) ion channel Kelch_6 PF13964.1 KOO31507.1 - 0.0016 18.4 5.3 7.7 6.8 0.0 5.6 6 0 0 6 6 6 1 Kelch motif Coronavirus_5 PF05528.6 KOO31507.1 - 0.0019 17.9 4.0 1.4 8.8 0.2 3.6 2 1 1 4 4 4 2 Coronavirus gene 5 protein DUF282 PF03380.9 KOO31507.1 - 0.32 10.7 10.1 3.8 7.3 0.1 4.4 4 0 0 4 4 4 0 Caenorhabditis protein of unknown function, DUF282 NRDD PF13597.1 KOO31507.1 - 0.73 7.8 2.7 7.8 4.4 0.0 2.9 3 0 0 3 3 3 0 Anaerobic ribonucleoside-triphosphate reductase UCH PF00443.24 KOO31508.1 - 9.3e-45 152.8 0.0 1.3e-44 152.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOO31508.1 - 1.6e-16 60.6 0.0 2.4e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase SET PF00856.23 KOO31510.1 - 4.5e-06 27.0 0.1 3.8e-05 24.0 0.0 2.0 2 0 0 2 2 2 1 SET domain Voldacs PF03517.8 KOO31510.1 - 0.034 14.0 0.0 0.052 13.4 0.0 1.3 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling TPR_11 PF13414.1 KOO31511.1 - 2.5e-19 68.6 0.1 2.6e-10 39.7 0.0 3.0 1 1 2 3 3 3 2 TPR repeat TPR_16 PF13432.1 KOO31511.1 - 1.3e-16 60.7 2.5 1.1e-10 41.9 0.2 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO31511.1 - 3.3e-15 54.9 0.0 9.6e-07 28.5 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO31511.1 - 9e-13 47.0 1.7 8.8e-05 22.1 0.1 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOO31511.1 - 2.3e-11 43.2 2.1 7e-05 23.1 0.0 4.0 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO31511.1 - 9.7e-11 40.8 1.0 7.5e-05 22.1 0.1 4.4 4 2 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO31511.1 - 1.5e-09 38.0 0.6 0.0024 18.1 0.0 3.5 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO31511.1 - 2e-09 36.5 0.1 0.0051 16.4 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO31511.1 - 3.4e-09 36.5 0.5 3.7e-05 23.5 0.1 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO31511.1 - 2.7e-06 26.7 0.5 0.09 12.6 0.0 3.4 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 KOO31511.1 - 3e-06 27.2 0.0 0.32 11.5 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO31511.1 - 0.0016 18.2 0.5 1.6 8.6 0.0 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.1 KOO31511.1 - 0.0018 18.1 1.3 0.062 13.2 0.1 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_20 PF14561.1 KOO31511.1 - 0.028 14.5 0.1 9.5 6.4 0.0 2.8 1 1 2 3 3 3 0 Tetratricopeptide repeat Glyco_transf_29 PF00777.13 KOO31512.1 - 1.1e-31 109.9 0.0 2.2e-31 108.9 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase family 29 (sialyltransferase) EGF_2 PF07974.8 KOO31512.1 - 0.039 14.1 12.8 0.039 14.1 8.9 2.4 1 1 1 2 2 2 0 EGF-like domain Laminin_EGF PF00053.19 KOO31512.1 - 0.25 11.2 10.8 0.98 9.4 7.5 2.0 1 1 0 1 1 1 0 Laminin EGF-like (Domains III and V) hEGF PF12661.2 KOO31512.1 - 1 9.5 9.4 0.21 11.7 2.9 2.7 2 0 0 2 2 2 0 Human growth factor-like EGF EGF PF00008.22 KOO31512.1 - 2.9 7.9 9.0 1.6 8.7 3.9 2.3 2 0 0 2 2 2 0 EGF-like domain PIP5K PF01504.13 KOO31513.1 - 8.4e-39 133.1 0.0 1.1e-38 132.7 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Methyltransf_28 PF02636.12 KOO31513.1 - 3.7e-21 75.6 0.0 6e-21 74.9 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Chloroa_b-bind PF00504.16 KOO31514.1 - 2.8e-37 128.3 0.1 3.8e-37 127.9 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein RPAP1_C PF08620.5 KOO31515.1 - 4.3e-22 77.7 0.0 7.6e-22 76.9 0.0 1.4 1 0 0 1 1 1 1 RPAP1-like, C-terminal PIP5K PF01504.13 KOO31516.1 - 8.2e-29 100.4 0.0 1.6e-13 50.3 0.0 2.0 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase LVIVD PF08309.6 KOO31517.1 - 1.6e-51 170.9 41.3 1e-12 46.8 1.7 5.2 5 0 0 5 5 5 5 LVIVD repeat Beta_propel PF09826.4 KOO31517.1 - 2.1e-06 26.3 0.3 1 7.6 0.0 4.8 2 2 2 5 5 5 1 Beta propeller domain PSCyt3 PF07627.6 KOO31517.1 - 9.4e-05 22.2 0.1 15 5.5 0.0 5.0 5 0 0 5 5 5 1 Protein of unknown function (DUF1588) SBP56 PF05694.6 KOO31517.1 - 0.00063 18.3 0.0 0.23 9.9 0.0 3.4 1 1 2 4 4 4 1 56kDa selenium binding protein (SBP56) Lactonase PF10282.4 KOO31517.1 - 0.0031 16.6 5.0 1.1 8.3 0.1 3.2 1 1 1 3 3 3 3 Lactonase, 7-bladed beta-propeller Kelch_6 PF13964.1 KOO31517.1 - 0.082 13.1 6.4 4.7 7.5 0.1 3.3 3 0 0 3 3 3 0 Kelch motif MTTB PF06253.6 KOO31517.1 - 0.11 10.2 7.7 0.33 8.6 0.2 2.8 1 1 3 4 4 4 0 Trimethylamine methyltransferase (MTTB) PQQ_3 PF13570.1 KOO31517.1 - 0.3 11.4 25.7 12 6.3 0.5 5.7 5 0 0 5 5 5 0 PQQ-like domain Chitin_bind_4 PF00379.18 KOO31517.1 - 0.74 10.1 15.2 20 5.5 0.1 5.0 5 0 0 5 5 5 0 Insect cuticle protein Myb_DNA-binding PF00249.26 KOO31518.1 - 5.5e-08 32.7 0.0 1.1e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO31518.1 - 0.00013 21.9 0.1 0.00037 20.5 0.0 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain DUF155 PF02582.9 KOO31519.1 - 9.2e-08 32.1 0.2 1.3e-07 31.7 0.2 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 CCDC144C PF14915.1 KOO31519.1 - 0.051 12.4 0.0 0.067 12.0 0.0 1.1 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region SgrR_N PF12793.2 KOO31519.1 - 0.13 12.3 0.3 0.98 9.4 0.0 2.0 2 0 0 2 2 2 0 Sugar transport-related sRNA regulator N-term Sel1 PF08238.7 KOO31520.1 - 4.4e-26 90.7 42.6 2.5e-05 24.7 0.2 10.6 11 0 0 11 11 11 6 Sel1 repeat TPR_11 PF13414.1 KOO31520.1 - 0.00052 19.6 10.0 0.023 14.3 0.1 4.1 5 0 0 5 5 5 2 TPR repeat TPR_7 PF13176.1 KOO31520.1 - 0.0095 15.6 6.3 0.075 12.8 0.1 4.1 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO31520.1 - 0.011 15.3 3.0 3.5 7.4 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.1 KOO31520.1 - 0.029 14.5 0.8 32 5.0 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 KOO31520.1 - 0.04 14.6 0.4 0.04 14.6 0.3 5.9 6 1 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO31520.1 - 0.2 11.5 17.0 0.077 12.9 0.4 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO31520.1 - 0.21 12.3 0.0 0.21 12.3 0.0 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO31520.1 - 0.57 10.2 0.0 0.57 10.2 0.0 5.2 7 0 0 7 7 7 0 Tetratricopeptide repeat Cyclin PF08613.6 KOO31521.1 - 3.2e-08 34.0 0.0 4.9e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 KOO31521.1 - 9.6e-06 25.1 0.0 1.5e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain ABC1 PF03109.11 KOO31522.1 - 4.7e-31 107.2 0.0 1.9e-30 105.3 0.0 2.0 3 0 0 3 3 3 1 ABC1 family APH PF01636.18 KOO31522.1 - 0.00011 22.0 0.6 0.00032 20.5 0.3 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 KOO31522.1 - 0.032 13.5 0.0 0.056 12.7 0.0 1.3 1 0 0 1 1 1 0 RIO1 family ADK PF00406.17 KOO31523.1 - 4.7e-37 127.1 0.0 6.2e-37 126.7 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_18 PF13238.1 KOO31523.1 - 1.9e-09 37.9 0.1 5.9e-09 36.3 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO31523.1 - 2.6e-08 34.7 0.0 3.7e-08 34.2 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 KOO31523.1 - 7.8e-07 29.0 0.1 1.6e-06 28.0 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOO31523.1 - 0.0096 15.9 0.3 0.015 15.2 0.2 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.1 KOO31523.1 - 0.012 15.6 0.1 0.068 13.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 KOO31523.1 - 0.016 14.9 0.1 0.039 13.6 0.0 1.7 1 1 0 1 1 1 0 Part of AAA domain Thymidylate_kin PF02223.12 KOO31523.1 - 0.026 13.9 0.0 5.4 6.3 0.0 2.1 2 0 0 2 2 2 0 Thymidylate kinase AAA_22 PF13401.1 KOO31523.1 - 0.039 14.0 0.1 0.15 12.1 0.0 1.9 2 1 1 3 3 3 0 AAA domain Zeta_toxin PF06414.7 KOO31523.1 - 0.043 12.9 0.0 0.062 12.3 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin EF-hand_1 PF00036.27 KOO31524.1 - 1.7e-16 58.1 0.8 7.7e-06 24.8 0.4 3.4 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 KOO31524.1 - 1.9e-14 53.0 0.2 1.8e-07 30.6 0.0 3.1 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO31524.1 - 5.7e-14 50.6 0.9 0.003 17.2 0.0 3.8 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.1 KOO31524.1 - 1.3e-13 50.8 0.1 2.6e-09 37.0 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO31524.1 - 1.5e-09 36.7 1.8 0.0046 16.2 0.1 3.4 3 0 0 3 3 3 3 EF hand DUF4339 PF14237.1 KOO31524.1 - 0.004 16.6 0.0 0.69 9.5 0.0 2.8 2 1 1 3 3 3 1 Domain of unknown function (DUF4339) DNAPolymera_Pol PF11590.3 KOO31524.1 - 0.027 14.1 0.1 0.79 9.4 0.1 2.7 2 1 0 2 2 2 0 DNA polymerase catalytic subunit Pol EF-hand_9 PF14658.1 KOO31524.1 - 0.14 12.0 0.0 0.51 10.2 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain Voltage_CLC PF00654.15 KOO31525.1 - 5.8e-60 203.1 23.7 3e-59 200.8 16.5 2.1 1 1 0 1 1 1 1 Voltage gated chloride channel CBM_1 PF00734.13 KOO31525.1 - 1.9e-08 33.7 26.4 5.9e-07 29.0 0.9 3.3 3 0 0 3 3 3 2 Fungal cellulose binding domain SMC_N PF02463.14 KOO31526.1 - 1.1e-63 214.3 0.2 1.7e-63 213.7 0.1 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 KOO31526.1 - 2.7e-20 72.5 0.0 1.3e-19 70.2 0.0 2.3 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 KOO31526.1 - 3.8e-13 50.0 0.0 2.5e-05 24.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.1 KOO31526.1 - 5.5e-05 22.3 6.9 0.005 15.9 0.0 3.3 3 0 0 3 3 3 1 AAA ATPase domain AAA_23 PF13476.1 KOO31526.1 - 0.0011 19.3 22.2 0.0011 19.3 15.4 6.2 2 2 1 3 3 3 1 AAA domain AAA_29 PF13555.1 KOO31526.1 - 0.0012 18.3 0.0 0.0023 17.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Reo_sigmaC PF04582.7 KOO31526.1 - 0.17 10.9 11.9 1.4 7.9 0.0 4.2 2 2 2 4 4 4 0 Reovirus sigma C capsid protein FlaC_arch PF05377.6 KOO31526.1 - 0.28 11.0 5.6 0.24 11.3 0.2 3.7 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) ABC_tran PF00005.22 KOO31526.1 - 0.45 10.8 12.3 3 8.1 0.1 5.4 4 2 0 4 4 4 0 ABC transporter AAA_22 PF13401.1 KOO31526.1 - 1.8 8.6 6.5 7.2 6.7 0.0 4.7 5 0 0 5 5 5 0 AAA domain DnaJ PF00226.26 KOO31527.1 - 2.8e-23 81.3 0.1 4.2e-23 80.8 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain Tmemb_185A PF10269.4 KOO31527.1 - 3.6e-19 69.2 26.7 3.8e-18 65.9 11.8 2.9 1 1 2 3 3 3 2 Transmembrane Fragile-X-F protein DUF423 PF04241.10 KOO31527.1 - 0.043 13.7 0.1 0.043 13.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF423) IQ PF00612.22 KOO31530.1 - 0.026 14.1 1.1 0.076 12.6 0.8 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif Dyp_perox PF04261.7 KOO31532.1 - 0.013 14.2 0.3 0.02 13.6 0.2 1.3 1 0 0 1 1 1 0 Dyp-type peroxidase family IncA PF04156.9 KOO31532.1 - 0.32 10.5 15.7 7.9 6.0 10.9 2.1 1 1 0 1 1 1 0 IncA protein GAS PF13851.1 KOO31532.1 - 0.61 9.2 16.6 2.1 7.4 4.0 2.4 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding ADIP PF11559.3 KOO31532.1 - 0.88 9.4 16.2 0.37 10.6 3.3 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding TPR_MLP1_2 PF07926.7 KOO31532.1 - 1.1 8.9 19.9 10 5.8 0.1 3.0 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF3138 PF11336.3 KOO31532.1 - 6.3 4.8 8.7 0.1 10.7 0.7 1.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3138) GrpE PF01025.14 KOO31532.1 - 8.3 5.9 16.8 12 5.4 6.4 2.8 1 1 1 2 2 2 0 GrpE Ion_trans PF00520.26 KOO31533.1 - 1.2e-174 576.3 53.9 4.7e-48 163.0 6.9 4.5 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 KOO31533.1 - 6.2e-22 77.6 49.6 1.1e-10 40.5 0.3 9.1 7 2 2 9 9 9 7 Polycystin cation channel 2OG-FeII_Oxy_3 PF13640.1 KOO31533.1 - 4.4e-05 23.9 0.0 0.0002 21.8 0.0 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily HALZ PF02183.13 KOO31533.1 - 0.11 12.2 0.1 0.24 11.1 0.1 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper EF-hand_1 PF00036.27 KOO31534.1 - 1.5e-35 117.7 3.2 6.4e-05 21.9 0.0 6.5 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.1 KOO31534.1 - 1.8e-30 102.0 3.3 0.0014 18.3 0.0 6.7 6 0 0 6 6 6 6 EF-hand domain EF-hand_7 PF13499.1 KOO31534.1 - 2.8e-28 97.8 8.1 1.6e-08 34.5 0.6 4.4 4 1 0 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO31534.1 - 5.9e-24 83.4 3.1 3.4e-08 32.9 0.1 4.0 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO31534.1 - 2.1e-21 74.2 15.7 0.0011 18.2 0.1 6.9 6 0 0 6 6 6 6 EF hand SPARC_Ca_bdg PF10591.4 KOO31534.1 - 0.00064 19.7 0.2 0.84 9.6 0.0 4.0 4 0 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region Band_7 PF01145.20 KOO31535.1 - 0.00031 20.6 0.4 0.0009 19.1 0.0 1.8 2 0 0 2 2 2 1 SPFH domain / Band 7 family FAD_binding_7 PF03441.9 KOO31536.1 - 3e-102 341.5 1.4 4e-102 341.1 0.9 1.1 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.13 KOO31536.1 - 0.0025 17.5 0.1 0.024 14.4 0.0 2.4 3 0 0 3 3 3 1 DNA photolyase Cpn60_TCP1 PF00118.19 KOO31537.1 - 2.9e-141 471.4 1.5 3.3e-141 471.2 1.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PC-Esterase PF13839.1 KOO31538.1 - 7.5e-05 22.6 0.0 0.00035 20.4 0.0 2.1 1 1 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p Heme_oxygenase PF01126.15 KOO31539.1 - 2.7e-10 40.1 0.1 3.1e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Heme oxygenase Ice_nucleation PF00818.12 KOO31540.1 - 0.24 10.8 5.0 8.4 5.9 0.3 3.0 2 0 0 2 2 2 0 Ice nucleation protein repeat VCBS PF13517.1 KOO31541.1 - 1.9e-31 108.1 28.6 6.1e-14 52.1 4.3 3.4 1 1 2 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO31541.1 - 4.3e-18 64.4 21.8 2.2e-06 27.1 0.3 3.4 3 0 0 3 3 3 3 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO31541.1 - 2.1e-07 30.5 6.4 0.036 13.5 0.0 3.1 2 1 1 3 3 3 3 Insecticide toxin TcdB middle/N-terminal region EF-hand_1 PF00036.27 KOO31541.1 - 0.0064 15.7 6.0 5.1 6.6 0.1 3.3 3 0 0 3 3 3 3 EF hand Asp-B-Hydro_N PF05279.6 KOO31541.1 - 0.019 14.8 3.9 16 5.2 0.1 3.2 3 0 0 3 3 3 0 Aspartyl beta-hydroxylase N-terminal region EF-hand_5 PF13202.1 KOO31541.1 - 0.037 13.3 13.4 3 7.3 0.3 3.4 3 0 0 3 3 3 0 EF hand Nop52 PF05997.7 KOO31542.1 - 9.3e-53 178.8 0.0 1.2e-52 178.5 0.0 1.1 1 0 0 1 1 1 1 Nucleolar protein,Nop52 Sigma70_ner PF04546.8 KOO31542.1 - 5.5e-05 22.8 4.6 9.9e-05 22.0 3.2 1.4 1 0 0 1 1 1 1 Sigma-70, non-essential region CENP-B_dimeris PF09026.5 KOO31542.1 - 0.00028 21.0 12.1 0.00036 20.7 7.4 1.8 2 0 0 2 2 2 1 Centromere protein B dimerisation domain HEAT_2 PF13646.1 KOO31542.1 - 0.0011 19.1 0.0 0.0031 17.7 0.0 1.8 1 0 0 1 1 1 1 HEAT repeats Pectate_lyase_2 PF06917.7 KOO31542.1 - 0.012 13.9 0.1 0.8 7.8 0.0 2.1 2 0 0 2 2 2 0 Periplasmic pectate lyase Nucleoplasmin PF03066.10 KOO31542.1 - 0.013 15.0 7.3 0.022 14.3 5.1 1.3 1 0 0 1 1 1 0 Nucleoplasmin HEAT_EZ PF13513.1 KOO31542.1 - 0.019 15.4 0.1 0.082 13.4 0.0 2.2 2 0 0 2 2 2 0 HEAT-like repeat Cwf_Cwc_15 PF04889.7 KOO31542.1 - 0.1 12.2 5.6 0.15 11.7 3.9 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Rhabdo_ncap PF00945.13 KOO31542.1 - 0.28 9.7 1.1 0.4 9.2 0.8 1.1 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein FAM176 PF14851.1 KOO31542.1 - 0.39 10.3 5.4 0.05 13.2 0.8 1.6 2 0 0 2 2 2 0 FAM176 family RXT2_N PF08595.6 KOO31542.1 - 0.42 10.4 6.4 0.69 9.7 4.4 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal RRN3 PF05327.6 KOO31542.1 - 0.46 8.5 2.8 2.9 5.9 0.9 2.2 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.7 KOO31542.1 - 0.75 7.6 7.3 1 7.1 5.0 1.1 1 0 0 1 1 1 0 Nop14-like family PPP4R2 PF09184.6 KOO31542.1 - 0.79 9.2 9.0 1.2 8.5 6.3 1.3 1 0 0 1 1 1 0 PPP4R2 PBP1_TM PF14812.1 KOO31542.1 - 4.9 7.5 15.0 1.4 9.2 7.7 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Myc_N PF01056.13 KOO31542.1 - 6.8 5.7 6.7 13 4.8 4.6 1.4 1 0 0 1 1 1 0 Myc amino-terminal region Sod_Cu PF00080.15 KOO31544.1 - 7.4e-44 149.3 0.7 1.2e-43 148.6 0.5 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) TCRP1 PF14944.1 KOO31544.1 - 0.079 12.8 2.9 5.5 6.8 0.0 2.2 1 1 1 2 2 2 0 Tongue Cancer Chemotherapy Resistant Protein 1 RhoGEF PF00621.15 KOO31546.1 - 6.8e-26 91.2 0.0 1.1e-25 90.5 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain Imm46 PF15585.1 KOO31546.1 - 0.096 12.7 0.1 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 Immunity protein 46 Ras PF00071.17 KOO31547.1 - 1.1e-20 73.6 0.0 2.1e-17 62.9 0.0 2.2 2 0 0 2 2 2 2 Ras family Miro PF08477.8 KOO31547.1 - 3e-15 56.7 0.0 5.7e-09 36.5 0.0 2.7 3 0 0 3 3 2 2 Miro-like protein EF-hand_1 PF00036.27 KOO31547.1 - 1.8e-11 42.4 1.0 2.9e-05 23.0 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO31547.1 - 6e-11 41.2 1.7 1.1e-05 24.8 0.1 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO31547.1 - 8.8e-10 38.5 0.0 1.9e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO31547.1 - 1.9e-08 33.7 0.0 4.7e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO31547.1 - 7.5e-06 25.0 2.5 0.017 14.4 0.2 2.9 3 0 0 3 3 3 2 EF hand ABC_tran PF00005.22 KOO31547.1 - 0.0012 19.1 0.2 0.0029 17.9 0.1 1.6 1 0 0 1 1 1 1 ABC transporter Arf PF00025.16 KOO31547.1 - 0.0068 15.6 0.0 1.5 8.0 0.0 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_29 PF13555.1 KOO31547.1 - 0.012 15.1 0.0 0.027 14.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF258 PF03193.11 KOO31547.1 - 0.015 14.5 0.0 0.027 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 KOO31547.1 - 0.015 15.2 0.0 0.18 11.7 0.0 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.1 KOO31547.1 - 0.037 14.0 0.0 0.22 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain cobW PF02492.14 KOO31547.1 - 0.039 13.3 0.2 0.084 12.3 0.1 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.1 KOO31547.1 - 0.063 13.2 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 KOO31547.1 - 0.064 13.5 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.5 KOO31547.1 - 0.11 11.6 0.0 5.6 6.1 0.0 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit MobB PF03205.9 KOO31547.1 - 0.12 12.0 0.0 0.39 10.4 0.0 1.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 KOO31547.1 - 0.14 12.0 0.2 0.33 10.8 0.2 1.6 1 0 0 1 1 1 0 AAA domain ubiquitin PF00240.18 KOO31547.1 - 0.16 11.3 0.0 2 7.8 0.0 2.3 1 1 0 1 1 1 0 Ubiquitin family AAA_22 PF13401.1 KOO31547.1 - 0.19 11.8 0.0 0.88 9.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain Redoxin PF08534.5 KOO31548.1 - 4.8e-16 58.6 0.3 5.7e-15 55.1 0.1 1.9 1 1 1 2 2 2 1 Redoxin AhpC-TSA PF00578.16 KOO31548.1 - 0.0011 18.6 0.0 0.0016 18.1 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Glyco_transf_10 PF00852.14 KOO31549.1 - 6.8e-32 110.3 0.0 1.8e-31 109.0 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) EF-hand_6 PF13405.1 KOO31550.1 - 7.4e-10 37.8 0.0 0.0002 20.9 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO31550.1 - 1.5e-09 36.4 0.1 0.0012 17.9 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO31550.1 - 2.8e-08 33.7 0.0 7.2e-08 32.4 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO31550.1 - 7.5e-08 31.3 0.9 0.011 15.0 0.2 2.8 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO31550.1 - 0.019 14.5 0.2 1.9 8.1 0.0 3.1 3 0 0 3 3 3 0 EF-hand domain pair NHL PF01436.16 KOO31551.1 - 8.4e-07 28.6 0.1 0.028 14.3 0.0 5.9 6 0 0 6 6 6 1 NHL repeat F-box-like PF12937.2 KOO31552.1 - 3e-08 33.2 0.3 6.3e-08 32.2 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 KOO31552.1 - 0.00028 20.4 0.0 0.00086 18.8 0.0 1.8 1 0 0 1 1 1 1 F-box domain Ag332 PF04671.7 KOO31553.1 - 0.018 14.7 0.0 0.042 13.6 0.0 1.7 1 0 0 1 1 1 0 Erythrocyte membrane-associated giant protein antigen 332 Glyoxalase_2 PF12681.2 KOO31554.1 - 9.1e-06 26.2 0.7 0.0031 18.0 0.1 2.4 2 0 0 2 2 2 2 Glyoxalase-like domain Hamartin PF04388.7 KOO31555.1 - 0.12 11.0 12.7 0.15 10.6 8.8 1.1 1 0 0 1 1 1 0 Hamartin protein tRNA_synt_1c_R2 PF04557.10 KOO31555.1 - 2.5 8.8 6.7 0.53 11.0 0.5 2.3 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 DNA_pol_viral_N PF00242.12 KOO31555.1 - 3.7 6.4 12.1 2.7 6.9 3.2 2.1 2 0 0 2 2 2 0 DNA polymerase (viral) N-terminal domain Apc15p PF05841.6 KOO31555.1 - 6 7.6 8.3 2.3 8.9 0.2 2.5 2 0 0 2 2 2 0 Apc15p protein TPR_11 PF13414.1 KOO31556.1 - 4.4e-26 90.3 19.8 2.4e-10 39.8 0.2 4.4 2 2 2 4 4 4 4 TPR repeat TPR_2 PF07719.12 KOO31556.1 - 2.1e-24 83.4 23.5 1.7e-06 27.4 0.1 6.6 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_1 PF00515.23 KOO31556.1 - 7.9e-18 63.2 14.3 2.3e-06 26.9 0.0 6.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.1 KOO31556.1 - 2e-15 56.9 39.0 1.4e-07 32.0 2.2 5.4 3 3 2 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.1 KOO31556.1 - 1.3e-10 40.2 1.1 0.0011 18.6 0.0 3.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO31556.1 - 1.9e-09 37.3 18.1 0.16 11.9 0.0 4.5 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.1 KOO31556.1 - 8.9e-09 35.2 32.8 0.0058 17.1 0.3 7.4 3 2 3 7 7 6 4 Tetratricopeptide repeat TPR_17 PF13431.1 KOO31556.1 - 4.5e-08 32.6 3.9 0.01 15.9 0.0 3.8 4 0 0 4 4 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO31556.1 - 6.3e-08 32.3 7.5 7.6e-05 22.4 0.7 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO31556.1 - 7.6e-08 32.5 7.7 9.9e-05 22.6 0.8 5.1 2 2 4 6 6 6 2 Tetratricopeptide repeat TPR_4 PF07721.9 KOO31556.1 - 1.3e-06 28.2 23.6 0.098 13.1 0.3 6.7 5 2 0 5 5 4 4 Tetratricopeptide repeat Apc3 PF12895.2 KOO31556.1 - 2.2e-05 24.5 6.4 0.06 13.4 0.3 3.0 2 2 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 KOO31556.1 - 2.5e-05 24.4 22.2 0.34 11.4 0.1 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat NARP1 PF12569.3 KOO31556.1 - 0.00075 18.3 0.4 1.1 7.9 0.0 2.5 2 0 0 2 2 2 2 NMDA receptor-regulated protein 1 TPR_7 PF13176.1 KOO31556.1 - 0.0062 16.2 5.3 17 5.5 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_15 PF13429.1 KOO31556.1 - 0.02 13.9 15.1 0.16 11.0 0.3 3.7 2 2 2 4 4 4 0 Tetratricopeptide repeat YscW PF09619.5 KOO31556.1 - 0.034 13.8 0.0 14 5.4 0.0 2.6 2 0 0 2 2 2 0 Type III secretion system lipoprotein chaperone (YscW) YscO PF07321.7 KOO31556.1 - 3 7.6 7.4 12 5.6 0.1 2.9 3 0 0 3 3 3 0 Type III secretion protein YscO GAS PF13851.1 KOO31558.1 - 1.2e-79 266.2 28.3 1.2e-79 266.2 19.6 3.2 2 1 1 3 3 3 1 Growth-arrest specific micro-tubule binding DUF3584 PF12128.3 KOO31558.1 - 0.026 11.8 66.5 0.94 6.7 33.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) DUF948 PF06103.6 KOO31558.1 - 2.1 8.2 17.0 1.7 8.5 0.3 5.6 3 1 3 6 6 6 0 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.7 KOO31558.1 - 8.5 6.2 14.7 2.1 8.1 0.6 4.2 2 2 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_11 PF13414.1 KOO31559.1 - 3.9e-18 64.8 1.5 6e-16 57.8 0.3 2.1 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 KOO31559.1 - 1.3e-07 30.9 3.3 0.0077 15.7 0.2 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO31559.1 - 1.5e-06 27.6 2.5 0.075 12.9 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO31559.1 - 2e-05 24.4 0.4 0.28 11.4 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO31559.1 - 0.00062 20.3 2.5 0.00081 19.9 0.0 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO31559.1 - 0.0086 15.7 2.1 0.95 9.4 0.0 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat PKI PF02827.11 KOO31560.1 - 0.063 13.3 0.2 0.093 12.8 0.1 1.4 1 1 0 1 1 1 0 cAMP-dependent protein kinase inhibitor CAF1A PF12253.3 KOO31560.1 - 0.45 10.6 6.2 0.58 10.3 4.3 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A AAA_11 PF13086.1 KOO31561.1 - 5.6e-24 85.0 0.0 9.5e-24 84.2 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_12 PF13087.1 KOO31561.1 - 8.9e-17 61.1 0.0 1.5e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.1 KOO31561.1 - 0.0041 17.2 0.2 0.7 10.0 0.1 3.0 3 1 0 3 3 3 1 UvrD-like helicase C-terminal domain PhyH PF05721.8 KOO31562.1 - 3.4e-14 53.3 0.2 6.1e-14 52.5 0.1 1.5 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.1 KOO31562.1 - 0.0041 17.3 0.2 1.3 9.3 0.0 2.2 1 1 0 2 2 2 2 Putative 2OG-Fe(II) oxygenase Aldo_ket_red PF00248.16 KOO31565.1 - 2e-19 69.4 0.0 2.8e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Galactosyl_T PF01762.16 KOO31566.1 - 5.8e-06 26.0 0.0 1e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Galactosyltransferase EF-hand_1 PF00036.27 KOO31567.1 - 1.7e-29 98.7 0.8 3.2e-05 22.9 0.0 6.5 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.1 KOO31567.1 - 1.3e-27 95.7 5.0 1.1e-08 35.0 0.1 3.6 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO31567.1 - 8.5e-26 87.4 2.9 9.9e-05 21.9 0.0 6.7 6 0 0 6 6 6 5 EF-hand domain EF-hand_5 PF13202.1 KOO31567.1 - 9.6e-19 65.8 7.3 0.00023 20.3 0.0 6.8 6 1 0 6 6 6 4 EF hand EF-hand_8 PF13833.1 KOO31567.1 - 6.2e-18 64.1 9.8 0.0015 18.1 0.2 6.3 5 1 1 6 6 6 5 EF-hand domain pair zf-C2HC_2 PF13913.1 KOO31567.1 - 3.9e-09 35.9 17.3 9.8e-07 28.2 2.9 3.0 3 0 0 3 3 3 2 zinc-finger of a C2HC-type EF-hand_4 PF12763.2 KOO31567.1 - 6.5e-05 22.6 0.7 1.3 8.8 0.0 3.6 1 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO31567.1 - 0.00013 21.9 6.9 0.32 11.0 0.1 4.5 3 2 0 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region FAM180 PF15173.1 KOO31567.1 - 0.15 11.8 0.2 6.1 6.6 0.0 2.9 2 1 1 3 3 3 0 FAM180 family RNase_H2-Ydr279 PF09468.5 KOO31567.1 - 0.67 9.0 3.7 1 8.4 2.5 1.2 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) OEP PF02321.13 KOO31567.1 - 5.2 6.6 13.1 7.8 6.0 9.1 1.2 1 0 0 1 1 1 0 Outer membrane efflux protein zf-NADH-PPase PF09297.6 KOO31567.1 - 5.4 6.6 7.1 18 4.9 0.4 2.6 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain DAO PF01266.19 KOO31568.1 - 1.8e-48 165.2 8.3 4.1e-48 164.1 5.7 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 KOO31568.1 - 0.00025 20.9 0.8 0.00057 19.8 0.6 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.14 KOO31568.1 - 0.00095 18.3 0.1 0.0049 15.9 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.1 KOO31568.1 - 0.037 14.0 0.0 0.071 13.1 0.0 1.6 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 KOO31568.1 - 0.061 12.2 0.2 4.5 6.0 0.0 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein Thi4 PF01946.12 KOO31568.1 - 0.068 12.2 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Trypsin_2 PF13365.1 KOO31569.1 - 1.2e-13 51.0 0.4 2.1e-13 50.2 0.3 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.21 KOO31569.1 - 1.5e-11 44.2 0.1 2.1e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.1 KOO31569.1 - 5.6e-06 26.1 0.0 4.4e-05 23.2 0.0 2.2 2 0 0 2 2 2 1 PDZ domain Peptidase_S46 PF10459.4 KOO31569.1 - 0.0097 14.3 0.1 0.013 13.9 0.1 1.1 1 0 0 1 1 1 1 Peptidase S46 Peptidase_S7 PF00949.16 KOO31569.1 - 0.042 13.2 0.4 0.071 12.5 0.2 1.4 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease Phosphoesterase PF04185.9 KOO31571.1 - 1.4e-55 189.0 0.3 3.4e-55 187.7 0.2 1.5 1 1 0 1 1 1 1 Phosphoesterase family DUF3119 PF11317.3 KOO31572.1 - 4.1e-15 55.8 0.0 6.4e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3119) RabGAP-TBC PF00566.13 KOO31575.1 - 1.3e-21 77.0 0.0 1.7e-21 76.6 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GSAP-16 PF14959.1 KOO31575.1 - 0.13 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 gamma-Secretase-activating protein C-term AAA PF00004.24 KOO31577.1 - 7.1e-37 126.5 0.0 1.3e-36 125.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KOO31577.1 - 6.9e-06 25.8 0.0 1.8e-05 24.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOO31577.1 - 1.5e-05 25.0 0.1 6.4e-05 23.0 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 KOO31577.1 - 3e-05 24.1 0.1 0.00066 19.8 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 KOO31577.1 - 5.4e-05 23.1 0.0 9.1e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 KOO31577.1 - 0.0022 17.1 0.0 0.0043 16.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 KOO31577.1 - 0.0033 18.2 0.0 0.017 15.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 KOO31577.1 - 0.0043 16.1 0.0 0.0074 15.4 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin Mg_chelatase PF01078.16 KOO31577.1 - 0.0054 15.9 0.1 0.011 14.8 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 KOO31577.1 - 0.0062 15.9 0.7 0.044 13.1 0.5 2.1 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 KOO31577.1 - 0.0068 16.5 0.0 0.013 15.6 0.0 1.4 1 0 0 1 1 1 1 RNA helicase AAA_19 PF13245.1 KOO31577.1 - 0.0097 15.6 0.0 0.03 14.0 0.0 1.8 1 0 0 1 1 1 1 Part of AAA domain NACHT PF05729.7 KOO31577.1 - 0.029 14.0 0.0 0.058 13.0 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_28 PF13521.1 KOO31577.1 - 0.038 13.9 0.0 0.075 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 KOO31577.1 - 0.046 13.5 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.8 KOO31577.1 - 0.057 12.1 0.0 0.086 11.5 0.0 1.1 1 0 0 1 1 1 0 TIP49 C-terminus IstB_IS21 PF01695.12 KOO31577.1 - 0.057 12.8 0.1 0.24 10.7 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein Arch_ATPase PF01637.13 KOO31577.1 - 0.065 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase AAA_18 PF13238.1 KOO31577.1 - 0.1 12.8 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain UPF0079 PF02367.12 KOO31577.1 - 0.11 12.0 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_3 PF07726.6 KOO31577.1 - 0.12 12.0 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 KOO31577.1 - 0.25 10.0 0.0 0.36 9.4 0.0 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein Parvo_NS1 PF01057.12 KOO31577.1 - 0.3 9.9 0.0 0.49 9.2 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 MFS_1 PF07690.11 KOO31578.1 - 4.5e-25 88.1 42.3 4.8e-16 58.4 15.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 KOO31578.1 - 1.6e-23 83.0 18.9 3.8e-23 81.7 13.1 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter DDDD PF10161.4 KOO31578.1 - 1.6 8.4 4.7 5.5 6.6 0.1 2.9 3 0 0 3 3 3 0 Putative mitochondrial precursor protein PAE PF03283.8 KOO31579.1 - 2.7e-61 207.2 0.0 3.8e-61 206.7 0.0 1.1 1 0 0 1 1 1 1 Pectinacetylesterase SAS4 PF15460.1 KOO31580.1 - 0.049 13.5 0.0 0.064 13.1 0.0 1.2 1 0 0 1 1 1 0 Something about silencing, SAS, complex subunit 4 Ank_2 PF12796.2 KOO31581.1 - 7.2e-12 45.4 0.0 1.3e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO31581.1 - 8.7e-10 38.8 0.5 2.8e-07 30.8 0.1 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO31581.1 - 2.4e-09 36.5 0.0 3.7e-07 29.6 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.1 KOO31581.1 - 3.6e-09 36.5 0.1 8.5e-08 32.2 0.1 2.6 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO31581.1 - 2.9e-07 30.0 0.0 3.7e-06 26.6 0.0 2.6 3 0 0 3 3 3 1 Ankyrin repeat DEAD PF00270.24 KOO31582.1 - 2.2e-39 134.6 0.0 1.5e-38 131.9 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO31582.1 - 3.3e-22 78.1 0.1 5.7e-22 77.3 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO31582.1 - 0.016 15.0 0.0 0.049 13.4 0.0 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Peptidase_S28 PF05577.7 KOO31584.1 - 1.7e-39 135.6 0.0 1.3e-32 112.9 0.0 2.5 2 1 0 2 2 2 2 Serine carboxypeptidase S28 Abhydrolase_6 PF12697.2 KOO31584.1 - 1.4e-06 28.3 0.6 5.7e-06 26.3 0.2 1.9 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO31584.1 - 1.1e-05 25.1 0.0 2e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Trypan_PARP PF05887.6 KOO31584.1 - 2e-05 24.4 4.6 4.1e-05 23.4 3.2 1.5 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Peptidase_S37 PF05576.6 KOO31584.1 - 0.00013 20.5 0.0 0.00059 18.4 0.0 1.8 1 1 0 1 1 1 1 PS-10 peptidase S37 Peptidase_S9 PF00326.16 KOO31584.1 - 0.0098 15.1 0.1 0.016 14.4 0.1 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 KOO31584.1 - 0.022 14.5 0.1 0.038 13.7 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Ank_2 PF12796.2 KOO31586.1 - 1.7e-18 66.7 0.1 1.1e-08 35.2 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO31586.1 - 7.2e-18 63.4 0.3 3.8e-07 29.5 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 KOO31586.1 - 4.7e-14 52.4 0.1 8.8e-07 29.2 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO31586.1 - 3.6e-12 46.1 1.9 2.9e-08 33.7 0.2 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO31586.1 - 1e-10 40.7 1.7 2.7e-05 23.9 0.0 4.6 5 0 0 5 5 5 2 Ankyrin repeat Arm PF00514.18 KOO31587.1 - 0.0006 19.5 0.4 0.0049 16.6 0.3 2.6 1 1 0 1 1 1 1 Armadillo/beta-catenin-like repeat F-box PF00646.28 KOO31588.1 - 0.0016 18.0 0.1 0.0065 16.1 0.1 2.0 1 0 0 1 1 1 1 F-box domain DUF812 PF05667.6 KOO31589.1 - 6.6e-89 299.0 16.3 1e-52 179.5 15.1 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF812) CK2S PF15011.1 KOO31589.1 - 0.007 16.1 1.5 0.007 16.1 1.0 4.0 2 1 2 4 4 4 2 Casein Kinase 2 substrate Mo25 PF08569.6 KOO31589.1 - 2.8 6.9 7.6 0.24 10.3 1.3 2.0 2 1 1 3 3 3 0 Mo25-like Abhydrolase_5 PF12695.2 KOO31590.1 - 5.1e-12 45.7 0.0 6.3e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO31590.1 - 4.2e-10 39.9 0.1 6e-10 39.3 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 KOO31590.1 - 7.2e-06 25.7 0.0 1.1e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.15 KOO31590.1 - 0.0011 18.5 0.1 0.0015 18.0 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 KOO31590.1 - 0.0014 17.8 0.1 0.0022 17.2 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF818 PF05677.7 KOO31590.1 - 0.0087 14.8 0.0 0.011 14.4 0.0 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Lipase_3 PF01764.20 KOO31590.1 - 0.0095 15.5 0.0 0.024 14.2 0.0 1.7 1 1 0 1 1 1 1 Lipase (class 3) DLH PF01738.13 KOO31590.1 - 0.015 14.6 0.0 0.022 14.0 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family AXE1 PF05448.7 KOO31590.1 - 0.033 12.6 0.1 0.064 11.7 0.0 1.4 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) CRAL_TRIO PF00650.15 KOO31591.1 - 3.8e-17 62.2 0.0 5.1e-17 61.8 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.1 KOO31591.1 - 0.16 11.8 0.0 0.26 11.2 0.0 1.2 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain PARP PF00644.15 KOO31592.1 - 4.5e-13 49.1 0.0 6.9e-13 48.5 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain TIR_2 PF13676.1 KOO31592.1 - 1.2e-08 34.9 0.0 7.3e-08 32.4 0.0 2.3 3 0 0 3 3 3 1 TIR domain Ank_2 PF12796.2 KOO31592.1 - 2.9e-06 27.5 0.0 6.2e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO31592.1 - 0.00028 21.3 0.0 0.001 19.5 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.25 KOO31592.1 - 0.0035 17.0 0.2 0.017 14.9 0.1 2.2 2 0 0 2 2 2 1 Ankyrin repeat DNA_methylase PF00145.12 KOO31593.1 - 1.2e-12 47.5 0.0 2.6e-12 46.5 0.0 1.6 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase SAM_decarbox PF01536.11 KOO31593.1 - 0.45 9.1 0.0 0.73 8.4 0.0 1.2 1 0 0 1 1 1 0 Adenosylmethionine decarboxylase Herpes_DNAp_acc PF04929.7 KOO31593.1 - 0.76 8.6 0.0 0.76 8.6 0.0 2.8 3 1 1 4 4 4 0 Herpes DNA replication accessory factor SNF2_N PF00176.18 KOO31595.1 - 1.1e-21 76.9 0.0 4.3e-21 75.0 0.0 1.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain MutS_V PF00488.16 KOO31597.1 - 1e-21 77.4 0.0 3e-21 75.9 0.0 1.7 1 1 0 1 1 1 1 MutS domain V AAA_21 PF13304.1 KOO31597.1 - 0.00056 19.9 0.0 1 9.2 0.0 2.1 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 KOO31597.1 - 0.029 14.5 0.3 0.14 12.2 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.1 KOO31597.1 - 0.049 13.1 0.1 0.17 11.4 0.1 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain EF-hand_1 PF00036.27 KOO31598.1 - 5.2e-24 81.6 0.6 1.4e-05 23.9 0.0 5.5 5 0 0 5 5 5 5 EF hand EF-hand_6 PF13405.1 KOO31598.1 - 4.4e-19 66.6 2.3 0.0075 16.0 0.0 5.9 5 0 0 5 5 5 4 EF-hand domain EF-hand_7 PF13499.1 KOO31598.1 - 1.9e-18 66.3 0.0 1.3e-07 31.6 0.0 4.3 4 1 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO31598.1 - 4.3e-17 60.5 8.6 1.5e-05 24.1 0.0 5.2 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.1 KOO31598.1 - 3.6e-16 58.5 1.0 0.0017 17.9 0.0 4.8 4 1 1 5 5 5 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO31598.1 - 0.029 14.3 0.0 6.7 6.7 0.0 3.3 3 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region DUF155 PF02582.9 KOO31600.1 - 6.1e-40 136.9 0.0 1.1e-39 136.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 EF-hand_1 PF00036.27 KOO31600.1 - 2.4e-12 45.1 2.3 8.3e-06 24.7 0.3 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO31600.1 - 1.1e-11 43.5 6.3 1.4e-05 24.2 0.1 2.9 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO31600.1 - 1.3e-11 43.2 3.0 9.4e-05 21.9 0.2 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO31600.1 - 1.6e-10 40.9 1.2 4.1e-10 39.6 0.8 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO31600.1 - 4.1e-08 32.7 3.6 6e-08 32.1 1.5 2.0 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.2 KOO31600.1 - 0.029 14.0 1.3 0.11 12.2 0.1 2.3 2 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO31600.1 - 0.042 13.8 0.0 0.087 12.8 0.0 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Ank PF00023.25 KOO31602.1 - 1.4e-07 30.9 0.1 0.012 15.3 0.1 2.7 2 1 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 KOO31602.1 - 2.8e-06 27.5 0.0 5.9e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) LRR_5 PF13306.1 KOO31602.1 - 4.7e-06 26.3 0.0 7.1e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) Ank_5 PF13857.1 KOO31602.1 - 0.00029 20.9 0.4 0.0055 16.9 0.0 2.6 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO31602.1 - 0.0021 18.1 0.0 0.16 12.3 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.1 KOO31602.1 - 0.014 15.8 0.0 0.059 13.9 0.0 2.0 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Pyr_redox PF00070.22 KOO31603.1 - 1.2e-07 32.0 0.0 1e-06 29.0 0.0 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 KOO31603.1 - 0.0012 18.7 1.9 0.0023 17.8 0.0 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 KOO31603.1 - 0.0032 16.4 5.6 0.0042 16.0 0.1 2.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 KOO31603.1 - 0.0039 17.1 0.1 0.011 15.8 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.1 KOO31603.1 - 0.21 11.8 0.0 0.21 11.8 0.0 2.9 2 1 0 2 2 2 0 Putative NAD(P)-binding DUF4239 PF14023.1 KOO31603.1 - 0.45 9.8 2.6 0.45 9.8 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) UPF0020 PF01170.13 KOO31605.1 - 7.4e-28 97.3 0.0 1.1e-27 96.8 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 SAP PF02037.22 KOO31605.1 - 1.2e-12 47.0 0.0 2.2e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 SAP domain Methyltransf_26 PF13659.1 KOO31605.1 - 6.9e-10 38.9 0.8 1.4e-09 37.9 0.1 1.9 2 0 0 2 2 2 1 Methyltransferase domain THUMP PF02926.12 KOO31605.1 - 0.016 15.0 0.0 0.026 14.4 0.0 1.3 1 0 0 1 1 1 0 THUMP domain Methyltransf_18 PF12847.2 KOO31605.1 - 0.074 13.6 0.1 0.34 11.4 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain TIG PF01833.19 KOO31606.1 - 4.8e-17 61.7 11.0 1.9e-13 50.2 0.2 4.7 5 1 0 5 5 5 3 IPT/TIG domain PA14 PF07691.7 KOO31606.1 - 2.3e-06 27.3 0.1 0.001 18.6 0.0 2.5 2 0 0 2 2 2 2 PA14 domain AAA_28 PF13521.1 KOO31607.1 - 1.1e-06 28.6 0.0 1.8e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain TPR_12 PF13424.1 KOO31608.1 - 9e-30 102.4 20.9 1.4e-12 47.3 1.0 5.8 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_10 PF13374.1 KOO31608.1 - 6.1e-24 83.1 31.6 6.2e-07 29.1 0.7 8.2 7 1 0 7 7 7 4 Tetratricopeptide repeat NB-ARC PF00931.17 KOO31608.1 - 2.1e-11 43.2 0.0 3.1e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain NACHT PF05729.7 KOO31608.1 - 1e-09 38.3 0.0 2.6e-09 36.9 0.0 1.7 2 0 0 2 2 1 1 NACHT domain TPR_11 PF13414.1 KOO31608.1 - 8.1e-08 31.8 5.5 1.6e-07 30.8 0.9 3.4 3 0 0 3 3 3 1 TPR repeat AAA_16 PF13191.1 KOO31608.1 - 1.1e-06 28.8 2.1 1.1e-06 28.8 1.5 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 KOO31608.1 - 2.2e-05 24.6 0.1 0.00031 20.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain TPR_8 PF13181.1 KOO31608.1 - 3.8e-05 23.1 1.9 0.074 12.8 0.0 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat CHAT PF12770.2 KOO31608.1 - 0.00021 20.5 0.1 0.00049 19.3 0.1 1.7 1 0 0 1 1 1 1 CHAT domain TPR_17 PF13431.1 KOO31608.1 - 0.00022 21.1 4.4 2.5 8.5 0.0 5.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO31608.1 - 0.00032 21.2 1.7 0.00032 21.2 1.2 5.2 5 0 0 5 5 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO31608.1 - 0.00036 20.0 12.4 0.063 12.9 0.5 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO31608.1 - 0.00044 19.8 16.4 0.037 13.8 0.1 5.5 7 0 0 7 7 5 2 Tetratricopeptide repeat PPR PF01535.15 KOO31608.1 - 0.011 15.6 0.3 0.43 10.6 0.0 3.5 3 0 0 3 3 3 0 PPR repeat TPR_3 PF07720.7 KOO31608.1 - 0.019 14.7 0.4 0.86 9.4 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat IstB_IS21 PF01695.12 KOO31608.1 - 0.041 13.3 0.1 0.23 10.8 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_30 PF13604.1 KOO31608.1 - 0.067 12.7 3.7 0.23 11.0 0.1 2.6 2 0 0 2 2 2 0 AAA domain PPR_2 PF13041.1 KOO31608.1 - 0.14 12.1 0.1 6.4 6.8 0.0 2.8 2 0 0 2 2 2 0 PPR repeat family TPR_2 PF07719.12 KOO31608.1 - 0.35 10.9 18.4 0.54 10.3 0.6 5.4 7 0 0 7 7 4 0 Tetratricopeptide repeat Parvo_NS1 PF01057.12 KOO31608.1 - 0.36 9.6 0.0 0.58 8.9 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 TPR_14 PF13428.1 KOO31608.1 - 2 9.2 16.6 2.3 9.0 0.6 6.2 5 1 1 6 6 5 0 Tetratricopeptide repeat Pkinase PF00069.20 KOO31609.1 - 9.7e-36 123.2 0.0 1.3e-35 122.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31609.1 - 1.9e-26 92.6 0.0 3.6e-26 91.8 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO31609.1 - 2.5e-05 23.4 0.0 3.4e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO31609.1 - 0.0041 16.8 0.1 0.049 13.3 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family WD40 PF00400.27 KOO31610.1 - 2.9e-17 61.8 0.3 0.00038 20.2 0.0 4.3 4 0 0 4 4 4 4 WD domain, G-beta repeat DUF3515 PF12028.3 KOO31610.1 - 0.0039 16.4 0.2 0.0062 15.7 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3515) 3HCDH_N PF02737.13 KOO31611.1 - 2.5e-60 203.2 0.5 3.5e-60 202.7 0.4 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.17 KOO31611.1 - 1.1e-32 112.2 0.1 6.7e-32 109.7 0.0 2.2 2 1 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 KOO31611.1 - 3.3e-06 27.0 3.8 2.7e-05 24.0 2.6 2.1 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 KOO31611.1 - 0.002 18.5 3.5 0.013 15.9 2.4 2.1 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent AlaDh_PNT_C PF01262.16 KOO31611.1 - 0.0029 17.1 0.5 0.005 16.4 0.3 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.14 KOO31611.1 - 0.0045 16.1 1.0 0.0087 15.2 0.7 1.4 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Spidroin_MaSp PF11260.3 KOO31611.1 - 0.025 14.6 0.0 0.054 13.5 0.0 1.5 1 0 0 1 1 1 0 Major ampullate spidroin 1 and 2 NAD_Gly3P_dh_N PF01210.18 KOO31611.1 - 0.034 13.8 0.3 0.053 13.2 0.2 1.4 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pyr_redox PF00070.22 KOO31611.1 - 0.046 14.1 0.7 0.086 13.2 0.5 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 KOO31611.1 - 0.09 12.6 0.5 0.13 12.1 0.3 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 KOO31611.1 - 0.11 11.3 1.6 0.19 10.5 1.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase zf-Tim10_DDP PF02953.10 KOO31612.1 - 0.092 12.0 0.3 0.18 11.0 0.2 1.4 1 0 0 1 1 1 0 Tim10/DDP family zinc finger Amino_oxidase PF01593.19 KOO31613.1 - 2.2e-58 198.4 7.7 5.9e-57 193.7 5.3 2.2 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Hint PF01079.15 KOO31613.1 - 1.7e-23 82.9 0.0 2.6e-23 82.3 0.0 1.2 1 0 0 1 1 1 1 Hint module Pyr_redox_3 PF13738.1 KOO31613.1 - 1.1e-07 32.1 1.0 0.0071 16.4 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 KOO31613.1 - 1.5e-07 31.3 0.5 1.5e-07 31.3 0.3 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 KOO31613.1 - 2e-07 30.9 1.0 0.0018 18.1 0.1 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding Thi4 PF01946.12 KOO31613.1 - 0.0015 17.7 0.3 0.0029 16.7 0.2 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.9 KOO31613.1 - 0.013 15.3 0.4 0.42 10.4 0.2 2.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 KOO31613.1 - 0.054 11.9 0.4 2 6.7 0.1 2.2 2 0 0 2 2 2 0 HI0933-like protein Ipi1_N PF12333.3 KOO31615.1 - 0.064 13.2 0.1 7.2 6.6 0.0 2.2 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation SBBP PF06739.6 KOO31616.1 - 3.1e-15 55.6 46.5 0.00078 19.1 0.4 7.4 7 0 0 7 7 7 6 Beta-propeller repeat NMU PF02070.10 KOO31616.1 - 2.9 7.4 10.6 48 3.5 0.0 6.1 6 0 0 6 6 6 0 Neuromedin U Trypsin_2 PF13365.1 KOO31617.1 - 0.0041 17.1 0.0 0.006 16.5 0.0 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF2312 PF10073.4 KOO31619.1 - 0.049 13.0 0.2 0.41 10.0 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) Methyltransf_16 PF10294.4 KOO31620.1 - 2e-15 56.6 0.0 3e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.9 KOO31620.1 - 1.1e-05 24.9 0.0 1.8e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.2 KOO31620.1 - 2e-05 25.0 0.0 4.3e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO31620.1 - 0.00026 20.5 0.0 0.0004 19.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO31620.1 - 0.00055 19.6 0.0 0.0014 18.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO31620.1 - 0.00063 19.7 0.0 0.0013 18.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 KOO31620.1 - 0.0015 18.1 0.0 0.0022 17.6 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_32 PF13679.1 KOO31620.1 - 0.007 16.0 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO31620.1 - 0.0096 16.3 0.0 0.02 15.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO31620.1 - 0.013 15.9 0.0 0.023 15.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.8 KOO31620.1 - 0.022 13.9 0.0 0.049 12.7 0.0 1.5 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.14 KOO31620.1 - 0.033 13.7 0.0 0.053 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) tRNA_U5-meth_tr PF05958.6 KOO31620.1 - 0.036 12.7 0.0 0.055 12.1 0.0 1.2 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Methyltransf_2 PF00891.13 KOO31620.1 - 0.038 13.1 0.0 0.062 12.4 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase DUF938 PF06080.7 KOO31620.1 - 0.067 12.7 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF938) LCM PF04072.9 KOO31620.1 - 0.088 12.3 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Leucine carboxyl methyltransferase EF-hand_6 PF13405.1 KOO31622.1 - 3.2e-29 98.1 21.4 7.6e-05 22.2 0.6 6.4 6 0 0 6 6 6 6 EF-hand domain EF-hand_1 PF00036.27 KOO31622.1 - 1.3e-28 96.0 23.8 5.9e-05 22.0 2.1 6.4 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.1 KOO31622.1 - 2.6e-24 85.1 20.0 5.3e-11 42.5 1.1 4.2 2 1 4 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.1 KOO31622.1 - 2.2e-22 77.3 27.4 0.0028 16.9 0.4 6.4 6 0 0 6 6 6 6 EF hand EF-hand_8 PF13833.1 KOO31622.1 - 2.2e-19 68.7 26.7 2.3e-08 33.5 0.5 5.8 3 3 3 6 6 6 5 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO31622.1 - 1.9e-05 24.6 5.4 0.017 15.1 0.0 4.1 4 0 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO31622.1 - 0.0011 18.5 4.0 3.5 7.3 0.1 4.5 3 1 1 4 4 4 1 EF hand EF-hand_4 PF12763.2 KOO31622.1 - 0.003 17.2 0.5 0.003 17.2 0.4 3.7 3 1 2 5 5 5 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO31622.1 - 0.0077 16.1 0.7 21 5.1 0.0 4.3 4 2 1 5 5 5 0 EF-hand domain DUF3037 PF11236.3 KOO31622.1 - 0.1 12.6 0.0 10 6.2 0.0 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3037) Ish1 PF10281.4 KOO31622.1 - 0.23 11.5 6.6 0.71 9.9 0.1 3.4 3 0 0 3 3 3 0 Putative stress-responsive nuclear envelope protein P2X_receptor PF00864.14 KOO31625.1 - 5.5e-29 101.0 0.0 1.8e-17 63.1 0.0 2.1 2 0 0 2 2 2 2 ATP P2X receptor DUF1897 PF09005.5 KOO31625.1 - 0.11 11.9 1.6 0.32 10.4 1.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1897) Nodulin_late PF07127.6 KOO31625.1 - 0.88 9.7 2.8 1.8 8.7 2.0 1.5 1 0 0 1 1 1 0 Late nodulin protein DNA_pol_viral_C PF00336.13 KOO31627.1 - 0.017 14.4 0.0 0.035 13.3 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain Complex1_LYR PF05347.10 KOO31628.1 - 2.1e-08 33.8 0.0 6.9e-08 32.1 0.0 1.9 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 KOO31628.1 - 1e-07 32.0 0.0 3.2e-07 30.4 0.0 1.9 1 0 0 1 1 1 1 Complex1_LYR-like HAUS6_N PF14661.1 KOO31628.1 - 0.0011 18.4 5.5 0.0011 18.4 3.8 2.1 1 1 1 2 2 2 1 HAUS augmin-like complex subunit 6 N-terminus V_ATPase_I PF01496.14 KOO31628.1 - 0.092 10.5 1.6 0.14 10.0 1.1 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Prominin PF05478.6 KOO31628.1 - 0.11 10.0 0.7 0.14 9.6 0.5 1.1 1 0 0 1 1 1 0 Prominin YtxH PF12732.2 KOO31628.1 - 0.49 10.7 7.0 2.6 8.4 4.8 2.5 1 1 0 1 1 1 0 YtxH-like protein Med9 PF07544.8 KOO31628.1 - 0.53 10.0 3.7 0.89 9.3 2.1 1.8 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 TPR_MLP1_2 PF07926.7 KOO31630.1 - 0.00021 21.0 17.7 0.00037 20.2 6.9 2.2 2 0 0 2 2 2 1 TPR/MLP1/MLP2-like protein Spc24 PF08286.6 KOO31630.1 - 0.0055 16.4 1.1 0.0055 16.4 0.8 3.0 1 1 2 3 3 3 1 Spc24 subunit of Ndc80 SlyX PF04102.7 KOO31630.1 - 0.0085 16.4 10.5 0.5 10.7 0.9 3.2 2 1 0 3 3 3 2 SlyX CALCOCO1 PF07888.6 KOO31630.1 - 0.062 11.5 11.5 0.078 11.2 7.9 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like B3_4 PF03483.12 KOO31630.1 - 0.081 12.3 0.1 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 B3/4 domain Cep57_MT_bd PF06657.8 KOO31630.1 - 0.082 12.8 9.3 1.4 8.9 0.3 3.2 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Tropomyosin_1 PF12718.2 KOO31630.1 - 0.094 12.5 22.6 0.038 13.8 10.3 2.1 1 1 1 2 2 2 0 Tropomyosin like NPV_P10 PF05531.7 KOO31630.1 - 0.12 12.6 1.0 2.9 8.2 0.0 2.5 3 1 0 3 3 2 0 Nucleopolyhedrovirus P10 protein DUF4201 PF13870.1 KOO31630.1 - 0.12 11.7 13.7 0.57 9.6 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) FlaC_arch PF05377.6 KOO31630.1 - 0.33 10.8 5.6 1.4 8.8 0.1 2.8 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) ADIP PF11559.3 KOO31630.1 - 0.34 10.7 16.1 7.8 6.3 4.4 3.0 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding DUF4191 PF13829.1 KOO31630.1 - 0.35 9.9 2.0 0.85 8.6 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4191) DUF4600 PF15372.1 KOO31630.1 - 0.4 10.9 8.6 0.18 12.0 3.0 2.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4600) CENP-F_leu_zip PF10473.4 KOO31630.1 - 0.44 10.4 19.9 0.3 10.9 8.2 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 EzrA PF06160.7 KOO31630.1 - 0.46 8.5 7.6 0.99 7.5 5.3 1.6 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Rop-like PF05082.8 KOO31630.1 - 0.67 9.4 12.0 2 7.9 0.4 3.8 4 1 0 4 4 4 0 Rop-like ERM PF00769.14 KOO31630.1 - 0.72 9.3 23.1 0.46 9.9 9.7 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family PhoU PF01895.14 KOO31630.1 - 1.7 9.1 8.8 7.6 7.0 1.8 2.7 2 1 0 2 2 2 0 PhoU domain Striatin PF08232.7 KOO31630.1 - 3.4 7.9 13.8 3.4 7.9 5.1 2.5 1 1 1 2 2 2 0 Striatin family PEARLI-4 PF05278.7 KOO31630.1 - 3.8 6.7 11.8 16 4.7 4.9 2.2 2 1 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) DUF4618 PF15397.1 KOO31630.1 - 4.2 6.6 11.1 3.5 6.8 5.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) DUF4164 PF13747.1 KOO31630.1 - 4.4 7.5 23.4 44 4.3 1.2 3.4 2 2 0 2 2 2 0 Domain of unknown function (DUF4164) FliD_C PF07195.7 KOO31630.1 - 5.5 6.1 6.7 23 4.2 1.4 2.5 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Lge1 PF11488.3 KOO31630.1 - 5.6 7.2 6.8 28 4.9 1.3 2.9 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 MRP-L28 PF09812.4 KOO31630.1 - 7 6.4 10.2 16 5.3 6.3 2.1 1 1 0 1 1 1 0 Mitochondrial ribosomal protein L28 AAA_13 PF13166.1 KOO31630.1 - 7.5 4.8 10.1 12 4.2 6.3 1.7 1 1 0 1 1 1 0 AAA domain APG6 PF04111.7 KOO31630.1 - 7.7 5.4 18.0 1.8 7.5 7.5 2.0 1 1 1 2 2 2 0 Autophagy protein Apg6 ATG16 PF08614.6 KOO31630.1 - 7.9 6.2 18.1 5.4 6.7 7.6 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Prefoldin_2 PF01920.15 KOO31630.1 - 8.7 6.1 16.3 9.9 5.9 1.7 3.2 2 1 0 3 3 3 0 Prefoldin subunit GTSE1_N PF15259.1 KOO31630.1 - 9 6.2 8.9 3.3 7.6 3.4 2.2 2 1 0 2 2 2 0 G-2 and S-phase expressed 1 HlyD PF00529.15 KOO31630.1 - 9 5.4 15.1 11 5.2 10.4 1.1 1 0 0 1 1 1 0 HlyD family secretion protein Cortex-I_coil PF09304.5 KOO31630.1 - 9.3 6.3 20.5 6.2 6.9 7.9 2.4 1 1 0 2 2 2 0 Cortexillin I, coiled coil Mg_trans_NIPA PF05653.9 KOO31631.1 - 0.00063 18.7 10.2 0.0084 15.0 4.6 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA CENP-F_leu_zip PF10473.4 KOO31631.1 - 0.001 18.9 11.4 0.001 18.9 7.9 5.4 3 3 1 4 4 4 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2408 PF10303.4 KOO31631.1 - 0.016 15.2 2.2 0.016 15.2 1.6 3.6 4 1 0 4 4 4 0 Protein of unknown function (DUF2408) EamA PF00892.15 KOO31631.1 - 5.4 7.0 16.9 0.74 9.8 6.2 2.4 1 1 1 2 2 2 0 EamA-like transporter family EmrE PF13536.1 KOO31631.1 - 8.2 6.6 15.8 0.2 11.8 6.2 1.8 2 0 0 2 2 2 0 Multidrug resistance efflux transporter EF-hand_1 PF00036.27 KOO31632.1 - 4.1e-42 138.2 10.3 3.1e-06 26.0 0.0 7.7 8 0 0 8 8 8 7 EF hand EF-hand_7 PF13499.1 KOO31632.1 - 1.4e-36 124.4 6.1 7.3e-10 38.8 0.0 4.5 3 1 0 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO31632.1 - 1.8e-36 120.7 11.2 9.4e-06 25.0 0.0 8.0 8 0 0 8 8 8 7 EF-hand domain EF-hand_8 PF13833.1 KOO31632.1 - 4.1e-31 106.3 13.4 4.4e-08 32.6 0.1 6.9 5 2 2 7 7 7 6 EF-hand domain pair EF-hand_5 PF13202.1 KOO31632.1 - 8.7e-28 94.4 16.3 3.2e-05 23.0 0.0 7.8 8 0 0 8 8 8 6 EF hand EF-hand_4 PF12763.2 KOO31632.1 - 0.00067 19.3 1.6 5.9 6.6 0.0 4.1 4 0 0 4 4 4 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO31632.1 - 0.00086 19.3 0.0 14 5.7 0.0 4.0 3 3 1 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOO31632.1 - 0.0027 17.5 0.0 17 5.4 0.0 4.0 4 0 0 4 4 4 1 EF-hand domain AA_permease_2 PF13520.1 KOO31634.1 - 4.3e-38 130.9 14.9 7.3e-38 130.2 10.2 1.4 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KOO31634.1 - 1.1e-21 76.7 18.9 2e-21 75.9 13.1 1.3 1 0 0 1 1 1 1 Amino acid permease Paf1 PF03985.8 KOO31634.1 - 0.33 9.6 2.2 0.45 9.1 1.5 1.1 1 0 0 1 1 1 0 Paf1 YfhO PF09586.5 KOO31634.1 - 0.73 7.7 2.0 1.2 7.0 1.4 1.2 1 0 0 1 1 1 0 Bacterial membrane protein YfhO CHCH PF06747.8 KOO31635.1 - 0.00068 19.4 5.7 0.15 11.9 0.1 2.6 2 0 0 2 2 2 2 CHCH domain NDUF_B7 PF05676.8 KOO31635.1 - 0.027 13.8 1.0 0.038 13.4 0.2 1.6 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) COX6B PF02297.12 KOO31635.1 - 0.067 13.2 5.2 0.59 10.1 3.6 2.1 1 1 0 1 1 1 0 Cytochrome oxidase c subunit VIb Pet191_N PF10203.4 KOO31635.1 - 0.086 12.8 2.1 4 7.5 0.1 2.4 2 1 0 2 2 2 0 Cytochrome c oxidase assembly protein PET191 TSP_1 PF00090.14 KOO31635.1 - 1.2 9.3 4.2 19 5.4 0.0 2.7 2 1 1 3 3 3 0 Thrombospondin type 1 domain EF-hand_8 PF13833.1 KOO31636.1 - 2.7e-10 39.6 0.0 0.00052 19.5 0.0 3.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO31636.1 - 6.4e-09 34.4 0.2 0.0039 16.4 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO31636.1 - 8.4e-08 32.2 0.0 2.6e-07 30.6 0.0 1.8 2 0 0 2 2 2 1 EF-hand domain pair FHA PF00498.21 KOO31636.1 - 2.9e-06 27.2 0.0 5.2e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 FHA domain EF-hand_6 PF13405.1 KOO31636.1 - 5.8e-06 25.7 0.3 0.038 13.8 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO31636.1 - 6.1e-06 25.3 0.2 0.077 12.3 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.2 KOO31636.1 - 0.0016 18.1 0.0 0.15 11.7 0.0 2.3 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand WW PF00397.21 KOO31636.1 - 0.0034 17.2 0.1 0.0062 16.3 0.1 1.4 1 0 0 1 1 1 1 WW domain PI3_PI4_kinase PF00454.22 KOO31638.1 - 1.9e-10 40.6 0.0 3e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase TPR_14 PF13428.1 KOO31639.1 - 0.0064 17.0 1.1 0.0064 17.0 0.8 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOO31639.1 - 0.021 14.7 0.4 0.07 13.0 0.0 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO31639.1 - 0.026 14.4 0.2 0.026 14.4 0.1 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 KOO31639.1 - 0.062 13.6 2.3 0.17 12.2 0.3 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOO31639.1 - 0.062 13.1 0.0 0.19 11.5 0.0 1.8 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_4 PF07721.9 KOO31639.1 - 0.13 12.7 0.0 0.13 12.7 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 KOO31639.1 - 0.41 10.6 0.1 0.41 10.6 0.1 2.2 2 1 0 2 2 2 0 Tetratricopeptide repeat cNMP_binding PF00027.24 KOO31640.1 - 2.7e-16 59.1 0.2 4.8e-16 58.3 0.1 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.11 KOO31640.1 - 1.9e-07 30.6 0.2 1.9e-07 30.6 0.1 1.8 2 0 0 2 2 2 1 Ion channel Ion_trans PF00520.26 KOO31640.1 - 0.0031 16.8 0.9 0.0061 15.8 0.2 1.8 1 1 1 2 2 2 1 Ion transport protein zf-rbx1 PF12678.2 KOO31641.1 - 5.6e-28 96.8 7.4 7e-28 96.5 5.1 1.1 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 KOO31641.1 - 3.2e-14 52.5 7.3 4.1e-14 52.1 5.1 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.1 KOO31641.1 - 7.8e-11 41.6 7.6 3.6e-10 39.5 5.2 1.9 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 KOO31641.1 - 7.6e-08 32.2 6.1 1.5e-07 31.3 1.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO31641.1 - 1.4e-07 31.0 1.1 4.1e-07 29.5 0.7 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO31641.1 - 8.5e-06 25.3 4.6 2.7e-05 23.8 3.2 1.7 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 KOO31641.1 - 8.1e-05 22.2 8.4 0.0011 18.6 5.9 2.0 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.3 KOO31641.1 - 0.0035 16.8 0.9 0.0058 16.1 0.7 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 KOO31641.1 - 0.0044 16.6 3.1 0.018 14.7 2.1 2.1 1 1 0 1 1 1 1 RING-type zinc-finger RINGv PF12906.2 KOO31641.1 - 0.0091 16.0 6.6 0.085 12.9 4.6 2.2 1 1 0 1 1 1 1 RING-variant domain zf-RING_6 PF14835.1 KOO31641.1 - 0.035 13.8 0.8 0.035 13.8 0.5 1.9 2 0 0 2 2 2 0 zf-RING of BARD1-type protein DUF2318 PF10080.4 KOO31641.1 - 0.042 13.6 0.2 1.6 8.5 0.0 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) zf-C3HC4_4 PF15227.1 KOO31641.1 - 0.058 13.2 4.3 0.058 13.2 3.0 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Rtf2 PF04641.7 KOO31641.1 - 0.1 11.8 1.3 0.12 11.4 0.1 1.7 2 0 0 2 2 2 0 Rtf2 RING-finger FANCL_C PF11793.3 KOO31641.1 - 5.1 7.1 9.1 73 3.4 6.5 2.6 1 1 1 2 2 2 0 FANCL C-terminal domain Mito_carr PF00153.22 KOO31642.1 - 2.5e-29 100.8 2.5 1.4e-15 56.7 0.1 2.4 2 0 0 2 2 2 2 Mitochondrial carrier protein ADK PF00406.17 KOO31644.1 - 3.9e-51 172.8 0.0 5.4e-51 172.4 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 KOO31644.1 - 1.3e-09 37.5 0.1 3.8e-08 32.8 0.0 2.4 1 1 0 1 1 1 1 Adenylate kinase, active site lid NDK PF00334.14 KOO31644.1 - 7.3e-06 25.8 0.0 0.0083 15.9 0.0 2.3 2 0 0 2 2 2 2 Nucleoside diphosphate kinase Zeta_toxin PF06414.7 KOO31644.1 - 2.7e-05 23.3 0.0 4.5e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.1 KOO31644.1 - 6.6e-05 22.8 0.0 0.00012 21.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO31644.1 - 0.00025 21.8 0.0 0.00053 20.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF2670 PF10875.3 KOO31644.1 - 0.17 11.8 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2670) TPR_14 PF13428.1 KOO31645.1 - 0.085 13.5 3.5 0.72 10.6 0.1 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat SET PF00856.23 KOO31647.1 - 6e-07 29.9 0.0 9.4e-05 22.7 0.0 2.3 1 1 0 1 1 1 1 SET domain Metallophos PF00149.23 KOO31648.1 - 3.9e-06 26.3 0.5 2e-05 24.0 0.4 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KOO31648.1 - 0.033 14.0 0.0 0.064 13.0 0.0 1.6 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain TPP_enzyme_M PF00205.17 KOO31648.1 - 0.07 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain TPT PF03151.11 KOO31649.1 - 1.4e-09 37.7 2.0 1.4e-09 37.7 1.4 2.8 2 1 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 KOO31649.1 - 3.1e-09 36.1 11.3 1.1e-08 34.4 7.8 1.9 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.15 KOO31649.1 - 0.003 17.5 9.4 0.003 17.5 6.5 3.3 3 1 1 4 4 4 2 EamA-like transporter family ESSS PF10183.4 KOO31649.1 - 0.32 11.4 4.1 5 7.5 2.8 2.6 1 1 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) SecY PF00344.15 KOO31650.1 - 1e-22 80.5 0.0 1.7e-22 79.8 0.0 1.3 1 0 0 1 1 1 1 SecY translocase Hint PF01079.15 KOO31650.1 - 4.4e-22 78.3 0.1 7.2e-22 77.6 0.0 1.2 1 0 0 1 1 1 1 Hint module PsbY PF06298.6 KOO31651.1 - 5.8 6.5 5.7 12 5.5 4.0 1.5 1 0 0 1 1 1 0 Photosystem II protein Y (PsbY) GLE1 PF07817.8 KOO31652.1 - 0.13 11.1 13.7 0.084 11.8 1.7 2.3 1 1 1 2 2 2 0 GLE1-like protein Bul1_C PF04426.7 KOO31652.1 - 0.15 11.2 0.0 0.15 11.2 0.0 3.1 3 0 0 3 3 3 0 Bul1 C terminus ABC1 PF03109.11 KOO31653.1 - 1.9e-24 85.9 0.0 3.5e-24 85.0 0.0 1.4 1 0 0 1 1 1 1 ABC1 family SUZ-C PF12901.2 KOO31653.1 - 0.14 11.8 1.1 5.8 6.6 0.2 3.5 4 0 0 4 4 4 0 SUZ-C motif Pkinase PF00069.20 KOO31654.1 - 6.1e-36 123.8 0.0 9.1e-36 123.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31654.1 - 1.8e-30 105.8 0.0 2.6e-30 105.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Methyltransf_11 PF08241.7 KOO31654.1 - 5.6e-12 45.9 0.0 1.3e-11 44.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO31654.1 - 3.1e-07 30.9 0.0 7.6e-07 29.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO31654.1 - 8e-07 29.3 0.0 1.7e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO31654.1 - 7.8e-06 25.5 0.0 2e-05 24.2 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain TIR_2 PF13676.1 KOO31654.1 - 4.7e-05 23.4 0.0 0.00017 21.6 0.0 1.9 2 0 0 2 2 2 1 TIR domain Kinase-like PF14531.1 KOO31654.1 - 0.00013 21.0 0.0 0.0002 20.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Methyltransf_26 PF13659.1 KOO31654.1 - 0.00019 21.4 0.1 0.0007 19.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO31654.1 - 0.00037 20.2 0.0 0.00073 19.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain APH PF01636.18 KOO31654.1 - 0.0015 18.3 0.7 0.0061 16.3 0.4 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Methyltransf_12 PF08242.7 KOO31654.1 - 0.0018 18.7 0.0 0.0044 17.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 KOO31654.1 - 0.055 12.8 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW TLD PF07534.11 KOO31655.1 - 4e-22 78.7 0.0 6.2e-22 78.0 0.0 1.3 1 0 0 1 1 1 1 TLD UQ_con PF00179.21 KOO31656.1 - 2.3e-21 75.6 0.0 3.2e-21 75.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 KOO31656.1 - 0.00023 21.0 0.0 0.00034 20.4 0.0 1.3 1 1 0 1 1 1 1 RWD domain NapB PF03892.9 KOO31656.1 - 0.048 13.3 0.2 0.24 11.0 0.0 2.1 3 0 0 3 3 3 0 Nitrate reductase cytochrome c-type subunit (NapB) Dimer_Tnp_hAT PF05699.9 KOO31658.1 - 1.2e-06 28.0 0.0 2.9e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region AKAP95 PF04988.7 KOO31658.1 - 0.00084 19.1 0.9 0.002 17.9 0.3 1.8 2 0 0 2 2 2 1 A-kinase anchoring protein 95 (AKAP95) CCDC84 PF14968.1 KOO31658.1 - 0.047 13.1 0.3 0.077 12.4 0.2 1.2 1 0 0 1 1 1 0 Coiled coil protein 84 PAN_4 PF14295.1 KOO31659.1 - 0.00043 19.9 1.9 0.0014 18.2 1.3 1.9 1 0 0 1 1 1 1 PAN domain AAA_5 PF07728.9 KOO31660.1 - 5.5e-75 249.6 0.0 3.4e-26 91.6 0.0 3.4 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) VWA_2 PF13519.1 KOO31660.1 - 6.4e-09 36.1 0.0 2.1e-08 34.4 0.0 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain AAA_22 PF13401.1 KOO31660.1 - 2.5e-08 34.1 0.1 7.1e-05 22.9 0.0 3.5 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KOO31660.1 - 1.5e-05 25.0 8.6 0.0012 18.9 1.1 4.7 3 2 1 4 4 3 1 AAA ATPase domain AAA PF00004.24 KOO31660.1 - 0.00012 22.3 0.0 0.011 15.9 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 KOO31660.1 - 0.001 18.9 0.0 0.096 12.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.6 KOO31660.1 - 0.0015 18.0 0.0 0.2 11.2 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 KOO31660.1 - 0.0026 18.5 0.0 0.0095 16.7 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 KOO31660.1 - 0.0026 17.6 0.0 0.81 9.5 0.0 2.7 3 0 0 3 3 2 1 AAA domain Mg_chelatase PF01078.16 KOO31660.1 - 0.004 16.3 5.1 0.92 8.6 0.1 3.6 3 1 1 4 4 4 2 Magnesium chelatase, subunit ChlI NACHT PF05729.7 KOO31660.1 - 0.0042 16.7 0.2 0.68 9.5 0.0 3.4 3 0 0 3 3 3 1 NACHT domain AAA_29 PF13555.1 KOO31660.1 - 0.026 14.0 0.0 5 6.7 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain DEAD PF00270.24 KOO31660.1 - 0.035 13.5 0.0 2.6 7.4 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase MobB PF03205.9 KOO31660.1 - 0.057 13.1 0.0 0.48 10.1 0.0 2.2 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_28 PF13521.1 KOO31660.1 - 0.086 12.7 0.0 0.4 10.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.21 KOO31660.1 - 0.13 11.7 0.0 22 4.4 0.0 2.7 2 1 0 2 2 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.12 KOO31660.1 - 0.15 11.4 0.0 1.1 8.6 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_2 PF07724.9 KOO31660.1 - 0.23 11.3 0.0 4.1 7.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) VWA PF00092.23 KOO31660.1 - 0.59 9.8 0.0 1 9.0 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain DUF1423 PF07227.6 KOO31660.1 - 8.8 4.8 1.7 13 4.2 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1423) RRM_1 PF00076.17 KOO31661.1 - 2.7e-61 203.1 2.4 3.4e-20 71.4 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO31661.1 - 1.2e-40 137.2 0.3 3e-13 49.5 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO31661.1 - 3e-31 107.0 0.1 3.2e-09 36.5 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.13 KOO31661.1 - 1e-25 89.1 0.2 1.3e-24 85.6 0.1 2.6 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain Arm PF00514.18 KOO31661.1 - 2.6e-09 36.5 1.6 8.3e-05 22.2 0.6 2.6 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat HEAT PF02985.17 KOO31661.1 - 8.8e-05 22.2 0.1 0.00077 19.3 0.0 2.4 2 0 0 2 2 2 1 HEAT repeat RRM_3 PF08777.6 KOO31661.1 - 0.0003 20.5 1.9 0.94 9.3 0.0 3.7 4 0 0 4 4 4 1 RNA binding motif HEAT_2 PF13646.1 KOO31661.1 - 0.00073 19.7 15.3 0.0012 19.1 3.3 2.6 1 1 1 2 2 2 2 HEAT repeats Limkain-b1 PF11608.3 KOO31661.1 - 0.00082 19.0 0.5 0.11 12.2 0.0 3.4 3 1 0 3 3 3 1 Limkain b1 CbiG_mid PF11761.3 KOO31661.1 - 0.074 13.2 0.0 9.8 6.4 0.0 2.8 2 0 0 2 2 2 0 Cobalamin biosynthesis central region HEAT_EZ PF13513.1 KOO31661.1 - 0.15 12.5 6.9 0.093 13.2 0.4 3.0 1 1 1 2 2 2 0 HEAT-like repeat TPT PF03151.11 KOO31664.1 - 0.00011 21.8 6.0 0.00011 21.8 4.2 2.5 3 0 0 3 3 3 1 Triose-phosphate Transporter family EamA PF00892.15 KOO31664.1 - 0.0002 21.3 14.3 0.00061 19.8 0.2 2.4 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.6 KOO31664.1 - 0.015 14.2 12.7 0.026 13.4 8.8 1.4 1 1 0 1 1 1 0 UAA transporter family Hid1 PF12722.2 KOO31664.1 - 0.12 10.0 0.0 0.15 9.7 0.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3529 PF12046.3 KOO31664.1 - 0.16 10.9 4.0 0.45 9.5 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3529) ETC_C1_NDUFA5 PF04716.9 KOO31665.1 - 1e-14 53.7 0.0 1.8e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 ETC complex I subunit conserved region PCI PF01399.22 KOO31666.1 - 4e-14 52.8 0.0 8e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 PCI domain Sigma70_r4_2 PF08281.7 KOO31666.1 - 0.014 14.8 0.3 0.2 11.1 0.0 2.6 2 0 0 2 2 2 0 Sigma-70, region 4 U3snoRNP10 PF12397.3 KOO31666.1 - 0.065 13.1 0.4 0.25 11.3 0.0 2.0 2 0 0 2 2 2 0 U3 small nucleolar RNA-associated protein 10 P21-Arc PF04062.9 KOO31667.1 - 2.5e-61 206.4 0.0 3.6e-61 205.9 0.0 1.2 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit Methyltransf_18 PF12847.2 KOO31668.1 - 4e-06 27.3 0.3 1e-05 26.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO31668.1 - 5.7e-06 26.7 0.0 1.1e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO31668.1 - 1.2e-05 25.6 0.0 2.7e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO31668.1 - 3.2e-05 23.5 0.0 4.9e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO31668.1 - 0.013 15.7 0.6 0.037 14.3 0.1 1.9 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_26 PF13659.1 KOO31668.1 - 0.017 15.1 0.1 0.017 15.1 0.1 2.3 2 1 0 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.13 KOO31668.1 - 0.031 13.3 0.0 0.041 12.9 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family MTS PF05175.9 KOO31668.1 - 0.043 13.1 0.1 0.043 13.1 0.1 1.5 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_16 PF10294.4 KOO31668.1 - 0.07 12.5 0.1 0.15 11.4 0.1 1.5 1 1 0 1 1 1 0 Putative methyltransferase Methyltransf_23 PF13489.1 KOO31668.1 - 0.082 12.6 0.0 0.11 12.1 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain SpaB_C PF14028.1 KOO31668.1 - 0.65 9.5 9.7 0.98 8.9 6.7 1.2 1 0 0 1 1 1 0 SpaB C-terminal domain Na_H_Exchanger PF00999.16 KOO31669.1 - 1e-44 152.6 29.2 1e-44 152.6 20.2 1.9 1 1 0 2 2 2 2 Sodium/hydrogen exchanger family Tbf5 PF06331.7 KOO31670.1 - 0.095 12.4 0.0 0.26 11.0 0.0 1.7 2 0 0 2 2 2 0 Transcription factor TFIIH complex subunit Tfb5 Peptidase_M24 PF00557.19 KOO31671.1 - 9.2e-51 172.3 0.0 1.3e-50 171.8 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 KOO31671.1 - 9.3e-14 50.9 0.0 1.7e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain AhpC-TSA PF00578.16 KOO31672.1 - 0.021 14.5 0.0 0.049 13.3 0.0 1.7 1 0 0 1 1 1 0 AhpC/TSA family LcrG PF07216.7 KOO31672.1 - 0.84 9.6 7.9 1.4 8.9 1.2 3.2 3 1 1 4 4 4 0 LcrG protein Activator-TraM PF11657.3 KOO31672.1 - 1.6 8.2 9.4 0.75 9.2 2.6 2.7 2 1 0 2 2 2 0 Transcriptional activator TraM V-ATPase_G PF03179.10 KOO31675.1 - 4e-28 97.7 9.2 4.6e-28 97.5 6.4 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit ADPrib_exo_Tox PF03496.9 KOO31675.1 - 0.0096 15.1 0.1 0.012 14.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Adenine_deam_C PF13382.1 KOO31675.1 - 0.1 11.7 0.2 0.18 10.9 0.1 1.5 1 1 1 2 2 2 0 Adenine deaminase C-terminal domain ATP-synt_B PF00430.13 KOO31675.1 - 0.97 9.2 11.5 1 9.1 7.3 1.6 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) Dabb PF07876.7 KOO31676.1 - 0.087 13.2 0.0 0.17 12.3 0.0 1.7 1 1 0 1 1 1 0 Stress responsive A/B Barrel Domain Pkinase PF00069.20 KOO31677.1 - 0.049 12.7 0.0 0.054 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain Pkinase PF00069.20 KOO31678.1 - 1e-56 191.9 0.0 1.4e-56 191.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31678.1 - 2.8e-34 118.3 0.0 3.7e-34 117.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO31678.1 - 0.0024 17.6 0.3 1.7 8.3 0.0 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 KOO31678.1 - 0.22 10.3 0.0 0.33 9.7 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 EF-hand_1 PF00036.27 KOO31679.1 - 7.9e-25 84.2 7.9 1.1e-05 24.3 0.1 5.5 6 0 0 6 6 6 4 EF hand EF-hand_7 PF13499.1 KOO31679.1 - 6.6e-22 77.4 6.1 3.1e-10 40.0 0.1 3.5 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO31679.1 - 3.4e-19 66.9 0.0 0.0085 15.8 0.0 5.8 6 0 0 6 6 5 5 EF-hand domain EF-hand_8 PF13833.1 KOO31679.1 - 1.4e-17 63.0 12.6 1.4e-06 27.8 0.3 4.5 4 1 1 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO31679.1 - 5e-17 60.3 7.9 0.0018 17.5 0.1 5.2 5 0 0 5 5 5 4 EF hand PDZ PF00595.19 KOO31679.1 - 1.9e-14 53.6 0.2 4.3e-06 26.8 0.0 3.4 3 0 0 3 3 3 2 PDZ domain (Also known as DHR or GLGF) EF-hand_4 PF12763.2 KOO31679.1 - 2.5e-09 36.7 1.5 0.055 13.2 0.1 3.6 3 1 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO31679.1 - 3e-09 36.8 0.0 0.039 13.9 0.0 3.4 3 0 0 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region PDZ_2 PF13180.1 KOO31679.1 - 4.3e-07 29.7 0.0 0.0021 17.9 0.0 2.8 2 0 0 2 2 2 2 PDZ domain EF-hand_9 PF14658.1 KOO31679.1 - 2.8e-05 23.9 0.4 0.36 10.7 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain Tricorn_PDZ PF14685.1 KOO31679.1 - 0.03 14.0 0.0 0.12 12.1 0.0 2.1 1 0 0 1 1 1 0 Tricorn protease PDZ domain RuvB_N PF05496.7 KOO31679.1 - 0.048 12.6 0.0 5.5 5.9 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase ruvB N-terminus EF-hand_10 PF14788.1 KOO31679.1 - 0.19 11.4 1.1 4.7 6.9 0.0 3.5 5 0 0 5 5 5 0 EF hand RibD_C PF01872.12 KOO31681.1 - 2.8e-35 121.7 0.0 3.8e-35 121.3 0.0 1.2 1 0 0 1 1 1 1 RibD C-terminal domain EF-hand_1 PF00036.27 KOO31682.1 - 1.7e-30 101.9 21.6 4.6e-09 34.9 0.0 4.4 5 0 0 5 5 4 4 EF hand EF-hand_7 PF13499.1 KOO31682.1 - 2.7e-28 97.9 9.4 4.4e-16 58.7 0.4 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO31682.1 - 1.8e-25 88.2 11.3 2.9e-12 46.0 0.2 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO31682.1 - 1.3e-24 83.7 15.2 4.8e-09 35.3 0.0 5.3 4 2 2 6 6 6 4 EF-hand domain EF-hand_5 PF13202.1 KOO31682.1 - 7.8e-20 69.2 20.7 3.5e-06 26.1 0.2 5.0 5 1 0 5 5 4 4 EF hand EF-hand_9 PF14658.1 KOO31682.1 - 7.2e-13 48.2 0.1 4.5e-07 29.6 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 KOO31682.1 - 3.1e-06 26.8 4.7 0.16 11.6 0.7 3.6 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO31682.1 - 0.0019 18.2 0.2 1.5 8.8 0.1 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region LETM1 PF07766.8 KOO31682.1 - 0.0096 14.9 0.2 0.013 14.5 0.2 1.4 1 0 0 1 1 1 1 LETM1-like protein Caleosin PF05042.8 KOO31682.1 - 0.013 15.0 0.1 5.5 6.5 0.0 2.5 2 1 0 2 2 2 0 Caleosin related protein Toprim_2 PF13155.1 KOO31682.1 - 0.02 15.2 1.8 6.4 7.1 0.0 2.4 1 1 0 2 2 2 0 Toprim-like Acetyltransf_11 PF13720.1 KOO31682.1 - 0.037 14.2 0.3 1.7 8.9 0.0 2.4 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 OST-HTH PF12872.2 KOO31682.1 - 0.047 13.5 0.1 15 5.4 0.0 3.2 3 1 1 4 4 4 0 OST-HTH/LOTUS domain Tenui_NCP PF04876.7 KOO31682.1 - 0.072 12.6 0.1 1.7 8.1 0.0 2.3 1 1 2 3 3 3 0 Tenuivirus major non-capsid protein UPF0154 PF03672.8 KOO31682.1 - 0.099 12.2 0.2 10 5.8 0.0 3.3 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0154) DUF21 PF01595.15 KOO31682.1 - 0.099 11.9 0.3 0.68 9.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF21 TyeA PF09059.5 KOO31682.1 - 0.1 12.5 0.1 0.43 10.5 0.0 1.9 2 0 0 2 2 2 0 TyeA DUF3008 PF11450.3 KOO31682.1 - 0.1 12.7 0.2 0.1 12.7 0.1 3.3 4 0 0 4 4 3 0 Protein of unknwon function (DUF3008) PMBR PF09373.5 KOO31682.1 - 0.13 12.2 0.2 19 5.4 0.0 4.2 6 0 0 6 6 6 0 Pseudomurein-binding repeat MgtE_N PF03448.12 KOO31682.1 - 0.22 11.8 2.3 0.62 10.4 0.1 2.4 2 1 0 2 2 2 0 MgtE intracellular N domain Endonuc-dimeris PF09124.5 KOO31682.1 - 0.24 11.0 3.8 4.1 7.1 0.0 3.0 3 1 0 3 3 3 0 T4 recombination endonuclease VII, dimerisation DUF4373 PF14297.1 KOO31682.1 - 0.25 11.6 2.2 66 3.8 0.0 3.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4373) EF-hand_10 PF14788.1 KOO31682.1 - 0.63 9.7 3.3 9.6 5.9 0.3 2.8 2 1 1 3 3 3 0 EF hand Bac_DNA_binding PF00216.16 KOO31683.1 - 7.2e-29 99.6 0.3 8.2e-29 99.4 0.2 1.0 1 0 0 1 1 1 1 Bacterial DNA-binding protein DUF4496 PF14908.1 KOO31683.1 - 0.0032 17.3 0.2 0.0062 16.4 0.1 1.5 1 1 1 2 2 2 1 Domain of unknown function (DUF4496) LacI PF00356.16 KOO31683.1 - 0.056 13.0 1.0 0.11 12.1 0.7 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family HU-DNA_bdg PF14848.1 KOO31683.1 - 0.068 12.8 0.0 0.16 11.6 0.0 1.5 2 0 0 2 2 2 0 DNA-binding domain S1-like PF14444.1 KOO31683.1 - 0.13 11.9 0.1 3.8 7.3 0.0 2.4 2 0 0 2 2 2 0 S1-like TRAM_LAG1_CLN8 PF03798.11 KOO31684.1 - 3.1e-08 33.4 2.0 4.4e-08 32.9 1.4 1.3 1 0 0 1 1 1 1 TLC domain DUF2583 PF10762.4 KOO31684.1 - 0.048 13.7 0.1 0.16 12.0 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2583) DEAD PF00270.24 KOO31685.1 - 9.1e-10 38.2 0.0 1.3e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO31685.1 - 0.0026 17.5 0.1 0.006 16.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain UVR PF02151.14 KOO31685.1 - 0.045 13.2 0.4 0.1 12.1 0.3 1.5 1 0 0 1 1 1 0 UvrB/uvrC motif T4SS-DNA_transf PF02534.9 KOO31685.1 - 0.11 11.0 0.0 0.15 10.5 0.0 1.1 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer Abhydrolase_5 PF12695.2 KOO31686.1 - 0.0091 15.7 0.1 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Endonuclease_7 PF02945.10 KOO31686.1 - 0.015 15.0 0.1 0.035 13.8 0.1 1.5 1 0 0 1 1 1 0 Recombination endonuclease VII DUF3089 PF11288.3 KOO31686.1 - 0.068 12.3 0.1 0.23 10.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3089) Neuropep_like PF15161.1 KOO31687.1 - 0.068 12.6 0.3 12 5.4 0.1 2.6 2 1 0 2 2 2 0 Neuropeptide-like SCP1201-deam PF14428.1 KOO31687.1 - 0.12 12.0 12.2 2.3 7.9 1.5 3.1 1 1 2 3 3 3 0 SCP1.201-like deaminase VCBS PF13517.1 KOO31688.1 - 3.2e-163 530.2 174.1 7.1e-14 51.9 3.1 15.1 1 1 14 15 15 15 15 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO31688.1 - 4.4e-84 274.4 157.9 2.9e-06 26.8 1.3 16.4 16 0 0 16 16 16 16 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO31688.1 - 1.1e-29 103.0 67.2 0.21 11.0 0.1 16.1 1 1 15 16 16 16 16 Insecticide toxin TcdB middle/N-terminal region DUF4384 PF14326.1 KOO31688.1 - 9.3e-09 35.0 0.1 22 4.9 0.0 10.5 4 3 9 13 13 13 0 Domain of unknown function (DUF4384) Arrestin_N PF00339.24 KOO31688.1 - 5.6e-06 26.2 0.0 34 4.2 0.0 8.9 13 0 0 13 13 13 0 Arrestin (or S-antigen), N-terminal domain EF-hand_5 PF13202.1 KOO31688.1 - 0.02 14.1 106.9 5.9 6.4 0.8 16.5 16 0 0 16 16 16 0 EF hand YuzL PF14115.1 KOO31688.1 - 0.1 12.9 35.2 98 3.3 0.0 13.7 15 0 0 15 15 15 0 YuzL-like protein Glyco_transf_56 PF07429.6 KOO31688.1 - 0.17 10.8 1.1 1.2e+02 1.4 0.0 5.7 9 0 0 9 9 9 0 4-alpha-L-fucosyltransferase glycosyl transferase group 56 EF-hand_1 PF00036.27 KOO31688.1 - 2.2 7.7 76.0 13 5.4 0.2 16.0 16 0 0 16 16 16 0 EF hand DnaJ PF00226.26 KOO31689.1 - 4.4e-05 23.1 0.0 0.00013 21.6 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain HATPase_c_2 PF13581.1 KOO31689.1 - 0.35 10.6 3.8 0.57 9.9 2.7 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain DUF1020 PF06255.8 KOO31689.1 - 0.81 8.8 5.0 1.1 8.4 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1020) DUF547 PF04784.9 KOO31692.1 - 2.6e-20 72.4 0.0 4.9e-20 71.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF547 DUF4427 PF14468.1 KOO31692.1 - 0.25 11.0 0.0 0.44 10.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4427) CTP_transf_1 PF01148.15 KOO31694.1 - 1.8e-05 24.5 3.5 3e-05 23.8 2.4 1.5 1 1 0 1 1 1 1 Cytidylyltransferase family DUF1576 PF07613.6 KOO31694.1 - 0.089 12.3 0.1 0.14 11.6 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1576) Bactofilin PF04519.8 KOO31696.1 - 0.019 14.9 1.6 0.11 12.5 0.4 2.2 2 0 0 2 2 2 0 Polymer-forming cytoskeletal Peptidase_G2 PF11962.3 KOO31696.1 - 0.14 11.2 0.7 0.29 10.2 0.0 2.0 3 0 0 3 3 3 0 Peptidase_G2, IMC autoproteolytic cleavage domain zf-TRAF PF02176.13 KOO31697.1 - 0.74 10.2 2.7 33 4.9 0.0 2.9 2 1 1 3 3 3 0 TRAF-type zinc finger EF-hand_6 PF13405.1 KOO31698.1 - 1.2e-14 52.7 0.6 8.1e-05 22.1 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.27 KOO31698.1 - 4.8e-14 50.5 0.3 0.00019 20.4 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.1 KOO31698.1 - 8.3e-14 51.4 0.4 9.2e-11 41.7 0.0 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO31698.1 - 4.6e-13 47.8 0.3 9e-05 21.6 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 KOO31698.1 - 1.7e-09 37.1 0.6 3.9e-06 26.3 0.0 2.9 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.2 KOO31698.1 - 0.0012 18.5 0.1 0.28 10.9 0.0 2.8 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand IQ PF00612.22 KOO31698.1 - 0.0013 18.1 4.9 0.094 12.4 0.3 3.1 3 0 0 3 3 3 2 IQ calmodulin-binding motif EF-hand_9 PF14658.1 KOO31698.1 - 0.019 14.8 0.0 0.068 13.0 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain Kri1 PF05178.7 KOO31699.1 - 1.8e-24 85.9 5.5 1.8e-24 85.9 3.8 4.8 5 1 0 5 5 5 1 KRI1-like family Kri1_C PF12936.2 KOO31699.1 - 1.3e-16 60.2 0.1 1.3e-16 60.2 0.0 3.5 4 0 0 4 4 4 1 KRI1-like family C-terminal Vpu PF00558.14 KOO31699.1 - 1.4 8.5 6.5 0.28 10.7 0.5 2.7 2 0 0 2 2 2 0 Vpu protein EF-hand_1 PF00036.27 KOO31700.1 - 1.1e-05 24.3 0.1 0.00029 19.9 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.1 KOO31700.1 - 0.00011 21.3 0.1 0.0016 17.7 0.0 2.7 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO31700.1 - 0.00055 19.6 0.1 0.012 15.4 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.1 KOO31700.1 - 0.0058 16.7 0.2 0.055 13.6 0.0 2.7 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO31700.1 - 0.0079 15.7 0.0 0.028 14.0 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain pair 2OG-FeII_Oxy_3 PF13640.1 KOO31701.1 - 4.1e-07 30.4 0.0 8.4e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.8 KOO31701.1 - 0.03 13.0 0.0 0.084 11.6 0.0 1.6 1 1 0 1 1 1 0 Poxvirus C4/C10 protein Histone PF00125.19 KOO31701.1 - 0.053 13.6 0.3 0.31 11.1 0.2 2.1 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 2OG-FeII_Oxy_4 PF13661.1 KOO31701.1 - 0.075 12.6 0.0 0.19 11.3 0.0 1.7 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Chromo PF00385.19 KOO31702.1 - 5.6e-07 29.1 0.1 9.7e-07 28.3 0.1 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DUF1856 PF08983.5 KOO31703.1 - 2e-05 24.5 0.1 2.8e+02 1.7 0.0 9.3 9 0 0 9 9 9 0 Domain of unknown function (DUF1856) Glycogen_syn PF05693.8 KOO31703.1 - 0.33 9.1 0.9 12 4.0 0.0 3.1 3 0 0 3 3 3 0 Glycogen synthase Proho_convert PF12177.3 KOO31703.1 - 1.9 8.1 3.2 87 2.8 0.0 4.7 7 0 0 7 7 7 0 Prohormone convertase enzyme MFS_1 PF07690.11 KOO31704.1 - 2.2e-22 79.2 59.9 7.6e-20 70.9 31.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily UreD PF01774.12 KOO31705.1 - 1.8e-22 79.8 0.0 2.1e-21 76.4 0.0 2.0 1 1 0 2 2 2 1 UreD urease accessory protein DEC-1_N PF04625.8 KOO31705.1 - 0.067 11.8 1.0 0.099 11.3 0.7 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region XPG_I PF00867.13 KOO31706.1 - 1.3e-18 66.8 0.0 2.3e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 KOO31706.1 - 1.5e-15 57.2 0.0 2.8e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.2 KOO31706.1 - 1.9e-07 30.8 0.0 2.8e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 XPG domain containing HemY_N PF07219.8 KOO31706.1 - 0.064 12.8 0.1 0.17 11.4 0.0 1.7 1 0 0 1 1 1 0 HemY protein N-terminus JmjC PF02373.17 KOO31707.1 - 2.1e-15 56.9 0.0 6.2e-15 55.4 0.0 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase Chromo PF00385.19 KOO31707.1 - 5.5e-07 29.1 2.3 1.2e-06 28.0 1.6 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Pectate_lyase_3 PF12708.2 KOO31708.1 - 0.0099 16.0 2.6 0.0099 16.0 1.8 1.8 1 1 1 2 2 2 1 Pectate lyase superfamily protein Beta_helix PF13229.1 KOO31708.1 - 0.013 15.2 10.3 0.018 14.8 7.1 1.4 1 1 0 1 1 1 0 Right handed beta helix region Arm PF00514.18 KOO31709.1 - 2.6e-73 239.5 63.3 2.6e-06 27.0 0.5 21.7 20 2 1 21 21 21 17 Armadillo/beta-catenin-like repeat ACC_central PF08326.7 KOO31709.1 - 6.4e-30 103.9 0.6 2.6e-28 98.6 0.0 2.8 2 1 0 2 2 2 1 Acetyl-CoA carboxylase, central region HEAT_2 PF13646.1 KOO31709.1 - 8.8e-09 35.5 62.8 0.003 17.8 3.0 10.2 8 2 5 13 13 13 6 HEAT repeats Arm_2 PF04826.8 KOO31709.1 - 1.6e-08 34.0 4.4 0.3 10.1 0.0 7.4 5 2 1 8 8 8 2 Armadillo-like Atx10homo_assoc PF09759.4 KOO31709.1 - 0.0058 16.3 10.0 3 7.6 0.0 6.6 8 1 0 8 8 8 2 Spinocerebellar ataxia type 10 protein domain TIG PF01833.19 KOO31709.1 - 0.0079 16.1 0.1 0.18 11.7 0.0 2.5 2 0 0 2 2 2 1 IPT/TIG domain HEAT PF02985.17 KOO31709.1 - 0.0093 15.9 10.9 1.1 9.4 0.2 7.3 7 0 0 7 7 7 1 HEAT repeat Peptidase_M13 PF01431.16 KOO31709.1 - 0.086 12.0 0.1 9.2 5.3 0.0 2.6 2 0 0 2 2 2 0 Peptidase family M13 Collagen PF01391.13 KOO31710.1 - 0.63 9.6 5.7 1.5 8.4 4.0 1.8 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) EF-hand_6 PF13405.1 KOO31711.1 - 1.4e-08 33.9 0.1 6e-05 22.5 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO31711.1 - 1.5e-07 31.4 0.0 0.00011 22.2 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO31711.1 - 2.6e-07 29.4 0.0 8.2e-05 21.6 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO31711.1 - 1.3e-05 24.2 0.1 0.0019 17.4 0.0 2.4 2 0 0 2 2 2 2 EF hand PDZ_2 PF13180.1 KOO31712.1 - 0.065 13.1 0.2 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 PDZ domain rve PF00665.21 KOO31713.1 - 6.9e-07 29.3 0.0 9.6e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain Aa_trans PF01490.13 KOO31714.1 - 8e-20 70.6 23.4 4.5e-19 68.2 6.7 2.2 1 1 1 2 2 2 2 Transmembrane amino acid transporter protein Gly_transf_sug PF04488.10 KOO31715.1 - 7.6e-05 23.0 0.0 0.00014 22.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif tRNA-synt_2b PF00587.20 KOO31716.1 - 3.4e-35 121.1 0.0 4.8e-35 120.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 KOO31716.1 - 2.9e-13 49.7 4.1 4.1e-13 49.2 2.8 1.2 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 PF07926.7 KOO31716.1 - 1.1 8.9 3.5 1.3 8.7 1.7 1.6 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Orthopox_A5L PF06193.6 KOO31717.1 - 0.14 12.1 3.4 0.12 12.3 0.8 1.9 1 1 1 2 2 2 0 Orthopoxvirus A5L protein-like GHMP_kinases_N PF00288.21 KOO31719.1 - 9e-10 38.4 5.2 9e-10 38.4 3.6 2.8 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 KOO31719.1 - 1.9e-06 27.9 0.3 9.3e-06 25.7 0.3 2.1 2 0 0 2 2 2 1 GHMP kinases C terminal SET PF00856.23 KOO31721.1 - 3.5e-06 27.4 0.0 9.2e-06 26.0 0.0 1.7 1 1 0 1 1 1 1 SET domain DUF4505 PF14956.1 KOO31722.1 - 7.4e-15 55.0 0.0 8.7e-15 54.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4505) TTL PF03133.10 KOO31723.1 - 2.2e-61 207.3 0.0 5.8e-61 205.9 0.0 1.7 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 KOO31723.1 - 3.9e-08 32.4 0.0 0.00078 18.3 0.0 2.7 3 0 0 3 3 3 2 YheC/D like ATP-grasp zf-DHHC PF01529.15 KOO31724.1 - 5.5e-27 94.2 0.2 9.8e-27 93.4 0.1 1.5 1 1 0 1 1 1 1 DHHC palmitoyltransferase DUF4109 PF13397.1 KOO31724.1 - 0.11 12.9 0.0 0.18 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4109) AAA_12 PF13087.1 KOO31725.1 - 2.7e-49 167.2 0.0 3.7e-49 166.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 KOO31725.1 - 1.4e-40 139.3 0.1 4.4e-40 137.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KOO31725.1 - 1.2e-13 50.5 13.7 2.9e-13 49.3 0.8 4.2 4 0 0 4 4 4 2 Part of AAA domain AAA_30 PF13604.1 KOO31725.1 - 9.5e-12 44.9 6.8 5.8e-09 35.8 0.2 3.6 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.13 KOO31725.1 - 2.2e-06 27.3 0.2 0.48 9.8 0.1 3.2 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.1 KOO31725.1 - 0.00019 21.5 0.1 0.0005 20.1 0.1 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Helicase_RecD PF05127.9 KOO31725.1 - 0.00082 19.0 0.8 0.019 14.6 0.5 2.6 1 1 0 1 1 1 1 Helicase AAA_16 PF13191.1 KOO31725.1 - 0.0013 18.7 1.0 0.0013 18.7 0.7 3.5 3 1 0 3 3 3 1 AAA ATPase domain Zot PF05707.7 KOO31725.1 - 0.0019 17.6 0.0 0.007 15.8 0.0 1.9 2 0 0 2 2 2 1 Zonular occludens toxin (Zot) IstB_IS21 PF01695.12 KOO31725.1 - 0.0019 17.6 0.1 0.0053 16.2 0.0 1.7 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_10 PF12846.2 KOO31725.1 - 0.026 13.9 0.0 0.094 12.1 0.0 1.7 1 1 0 2 2 2 0 AAA-like domain AAA_17 PF13207.1 KOO31725.1 - 0.053 14.3 0.0 0.14 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.4 KOO31725.1 - 0.068 12.1 0.1 0.48 9.3 0.1 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) KTI12 PF08433.5 KOO31725.1 - 0.17 11.0 0.0 0.32 10.1 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 UvrD_C PF13361.1 KOO31725.1 - 0.19 11.1 0.0 0.54 9.6 0.0 1.6 1 1 1 2 2 2 0 UvrD-like helicase C-terminal domain MobB PF03205.9 KOO31725.1 - 0.22 11.2 0.0 0.42 10.3 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 KOO31725.1 - 0.23 11.7 0.0 0.48 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Ank_4 PF13637.1 KOO31726.1 - 0.00059 20.2 0.1 0.0017 18.8 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.25 KOO31726.1 - 0.00088 18.9 0.1 0.0023 17.6 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.1 KOO31726.1 - 0.003 17.6 0.2 0.016 15.4 0.1 2.4 2 1 1 3 3 3 1 Ankyrin repeat Ank_2 PF12796.2 KOO31726.1 - 0.0051 17.1 0.0 0.01 16.1 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO31726.1 - 0.031 14.5 0.1 0.088 13.0 0.1 1.8 1 1 0 1 1 1 0 Ankyrin repeats (many copies) ResIII PF04851.10 KOO31727.1 - 0.00013 21.9 0.0 0.011 15.5 0.0 3.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.11 KOO31727.1 - 0.0016 17.7 0.0 0.0036 16.5 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein AAA_19 PF13245.1 KOO31727.1 - 0.0065 16.2 0.2 0.06 13.0 0.0 2.8 2 0 0 2 2 2 1 Part of AAA domain Radical_SAM PF04055.16 KOO31729.1 - 1.5e-14 54.4 0.0 2.1e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.1 KOO31729.1 - 0.039 13.9 0.0 0.084 12.8 0.0 1.5 1 0 0 1 1 1 0 4Fe-4S single cluster domain Miff PF05644.6 KOO31729.1 - 0.068 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff UCH PF00443.24 KOO31730.1 - 3.8e-62 209.8 0.0 4.5e-62 209.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOO31730.1 - 1.2e-27 97.1 0.0 1.5e-26 93.5 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.1 KOO31730.1 - 0.021 14.1 0.6 0.57 9.4 0.1 2.7 3 0 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase ERCC4 PF02732.10 KOO31732.1 - 6.2e-09 35.7 0.0 8.9e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 ERCC4 domain DUF3676 PF12429.3 KOO31732.1 - 0.029 13.9 2.1 0.04 13.5 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3676) UPF0118 PF01594.11 KOO31733.1 - 1.7e-28 99.5 25.1 3.5e-27 95.2 17.4 2.1 1 1 0 1 1 1 1 Domain of unknown function DUF20 DUF1689 PF07954.6 KOO31733.1 - 0.023 14.5 0.0 0.16 11.8 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1689) CbtB PF09489.5 KOO31733.1 - 0.071 13.0 0.7 0.38 10.6 0.5 2.3 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtB) Tetraspannin PF00335.15 KOO31733.1 - 8.5 5.5 10.0 0.11 11.7 0.3 2.5 2 1 1 3 3 3 0 Tetraspanin family ATP-synt_D PF01813.12 KOO31734.1 - 4.3e-62 209.1 5.0 4.3e-62 209.1 3.5 1.7 1 1 1 2 2 2 1 ATP synthase subunit D Borrelia_orfA PF02414.10 KOO31734.1 - 0.017 14.2 0.1 0.027 13.6 0.1 1.2 1 0 0 1 1 1 0 Borrelia ORF-A DUF2730 PF10805.3 KOO31734.1 - 0.035 13.8 2.9 0.13 12.0 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2730) Reo_sigmaC PF04582.7 KOO31734.1 - 0.1 11.7 1.3 0.16 11.1 0.2 1.6 2 0 0 2 2 2 0 Reovirus sigma C capsid protein NGP1NT PF08153.7 KOO31735.1 - 1.2e-40 138.5 0.0 1.9e-40 137.7 0.0 1.3 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.18 KOO31735.1 - 8.4e-19 67.6 0.0 4e-16 59.0 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.13 KOO31735.1 - 1.3e-06 27.8 0.1 6.5e-06 25.5 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.11 KOO31735.1 - 0.0004 19.6 0.0 0.00094 18.4 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function, DUF258 Arf PF00025.16 KOO31735.1 - 0.0005 19.3 0.0 0.12 11.6 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Dynamin_N PF00350.18 KOO31735.1 - 0.013 15.3 0.9 0.51 10.1 0.1 3.0 3 1 1 4 4 4 0 Dynamin family FAE1_CUT1_RppA PF08392.7 KOO31736.1 - 1.4e-105 352.5 0.0 1.7e-105 352.2 0.0 1.1 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein Chal_sti_synt_C PF02797.10 KOO31736.1 - 4.6e-11 42.8 0.0 1.2e-10 41.5 0.0 1.6 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain ACP_syn_III_C PF08541.5 KOO31736.1 - 1.7e-10 40.7 0.0 1.2e-09 38.0 0.0 2.2 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Chal_sti_synt_N PF00195.14 KOO31736.1 - 0.00091 18.5 0.1 0.0015 17.8 0.1 1.4 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain ketoacyl-synt PF00109.21 KOO31736.1 - 0.033 13.6 0.1 0.052 13.0 0.1 1.3 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.5 KOO31736.1 - 0.049 13.3 0.0 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF179 PF02622.10 KOO31737.1 - 1.6e-13 50.6 0.0 2e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized ACR, COG1678 DUF2470 PF10615.4 KOO31738.1 - 0.00021 21.4 0.0 0.00042 20.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) Pyrid_oxidase_2 PF13883.1 KOO31738.1 - 0.0051 16.5 0.0 0.011 15.5 0.0 1.6 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase IQ PF00612.22 KOO31739.1 - 1.2 8.9 14.8 2.1 8.2 0.8 4.5 3 0 0 3 3 3 0 IQ calmodulin-binding motif IQ PF00612.22 KOO31740.1 - 4.8e-15 53.6 43.7 0.0016 17.9 0.1 7.3 7 0 0 7 7 7 6 IQ calmodulin-binding motif EF-hand_7 PF13499.1 KOO31740.1 - 3.3e-07 30.3 0.0 9.1e-07 28.9 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO31740.1 - 3.4e-07 29.5 0.0 0.012 15.4 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO31740.1 - 6.7e-07 28.1 0.0 0.01 15.0 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO31740.1 - 4.6e-05 22.5 1.1 0.055 12.8 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO31740.1 - 0.0093 15.5 0.1 0.65 9.6 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain pair LMBR1 PF04791.11 KOO31740.1 - 0.58 8.6 3.4 0.91 8.0 2.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Aldo_ket_red PF00248.16 KOO31742.1 - 5.7e-34 117.2 0.0 7.9e-34 116.7 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family MMR_HSR1 PF01926.18 KOO31743.1 - 0.00018 21.4 0.0 0.00028 20.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 KOO31743.1 - 0.0091 15.4 0.0 0.025 14.0 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain NOG1 PF06858.9 KOO31744.1 - 1.9e-26 91.7 0.3 5.7e-26 90.1 0.2 1.9 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.18 KOO31744.1 - 6.9e-18 64.7 0.0 1.7e-17 63.4 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase NOGCT PF08155.6 KOO31744.1 - 1.1e-13 50.6 0.6 2.9e-13 49.3 0.4 1.7 1 0 0 1 1 1 1 NOGCT (NUC087) domain FeoB_N PF02421.13 KOO31744.1 - 1.5e-11 43.7 1.1 1.6e-11 43.7 0.0 1.6 2 0 0 2 2 2 1 Ferrous iron transport protein B Miro PF08477.8 KOO31744.1 - 6.5e-05 23.4 0.0 0.00021 21.7 0.0 2.0 1 0 0 1 1 1 1 Miro-like protein AIG1 PF04548.11 KOO31744.1 - 0.00078 18.6 0.8 0.0055 15.8 0.0 2.3 2 0 0 2 2 2 1 AIG1 family SRPRB PF09439.5 KOO31744.1 - 0.015 14.4 0.0 0.036 13.2 0.0 1.7 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit GerA PF03323.8 KOO31744.1 - 0.018 13.1 0.5 0.027 12.6 0.4 1.2 1 0 0 1 1 1 0 Bacillus/Clostridium GerA spore germination protein Lip_prot_lig_C PF10437.4 KOO31744.1 - 0.027 14.1 0.0 0.058 13.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial lipoate protein ligase C-terminus Dynamin_N PF00350.18 KOO31744.1 - 0.034 13.9 3.5 3.8 7.2 0.0 3.3 2 1 1 3 3 3 0 Dynamin family MobB PF03205.9 KOO31744.1 - 0.047 13.4 0.0 0.16 11.6 0.0 1.9 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Sec34 PF04136.10 KOO31744.1 - 0.066 12.9 0.1 0.3 10.7 0.1 2.0 2 0 0 2 2 2 0 Sec34-like family AAA_17 PF13207.1 KOO31744.1 - 0.11 13.3 0.1 1.4 9.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 KOO31744.1 - 0.11 11.6 0.0 0.51 9.5 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function, DUF258 TPR_12 PF13424.1 KOO31746.1 - 5.5e-40 135.1 14.7 6.9e-14 51.5 1.1 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.1 KOO31746.1 - 1.3e-27 94.8 40.4 1.5e-07 31.1 0.6 9.2 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_11 PF13414.1 KOO31746.1 - 1.2e-07 31.2 6.4 0.0012 18.4 0.1 4.5 2 2 2 5 5 5 3 TPR repeat TPR_1 PF00515.23 KOO31746.1 - 1.6e-06 27.4 4.0 0.45 10.2 0.0 5.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO31746.1 - 3.5e-06 26.5 10.6 0.16 11.9 0.0 6.2 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO31746.1 - 7e-06 25.4 11.3 0.92 9.4 0.0 6.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO31746.1 - 6.2e-05 22.8 0.1 7.3 7.0 0.0 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO31746.1 - 0.00021 21.8 13.8 0.0024 18.5 1.1 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO31746.1 - 0.0087 15.7 4.8 41 4.2 0.0 5.3 6 0 0 6 6 5 0 Tetratricopeptide repeat DUF630 PF04783.7 KOO31746.1 - 0.054 13.3 4.8 14 5.7 0.0 4.3 4 0 0 4 4 4 0 Protein of unknown function (DUF630) TPR_4 PF07721.9 KOO31746.1 - 0.072 13.5 0.0 0.072 13.5 0.0 6.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO31746.1 - 0.22 12.0 1.5 58 4.4 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Daxx PF03344.10 KOO31746.1 - 4.1 5.7 11.7 5.9 5.2 8.1 1.1 1 0 0 1 1 1 0 Daxx Family Ank_2 PF12796.2 KOO31747.1 - 2.4e-37 127.1 11.1 3.7e-20 72.0 0.8 2.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO31747.1 - 7.8e-20 69.6 10.8 7e-10 38.2 0.0 4.7 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.1 KOO31747.1 - 6.3e-18 64.3 5.5 1.2e-11 44.4 0.2 3.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO31747.1 - 8.3e-16 56.5 2.0 2.2e-05 24.2 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 KOO31747.1 - 1.3e-13 51.0 1.0 4.2e-06 27.1 0.1 2.9 3 0 0 3 3 3 2 Ankyrin repeats (many copies) JmjC PF02373.17 KOO31747.1 - 0.042 14.1 0.0 0.091 13.0 0.0 1.6 1 1 0 1 1 1 0 JmjC domain, hydroxylase DUF3994 PF13159.1 KOO31749.1 - 0.017 15.3 2.1 0.017 15.3 1.5 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3994) SPOR PF05036.8 KOO31749.1 - 0.098 12.8 0.6 0.098 12.8 0.4 3.9 2 2 2 4 4 4 0 Sporulation related domain Tropomyosin_1 PF12718.2 KOO31749.1 - 0.35 10.7 32.9 0.015 15.1 13.7 2.3 1 1 0 2 2 2 0 Tropomyosin like DNA_ligase_A_C PF04679.10 KOO31749.1 - 1 9.8 3.6 2 8.8 0.7 2.7 1 1 1 2 2 2 0 ATP dependent DNA ligase C terminal region DUF4472 PF14739.1 KOO31749.1 - 3.1 8.2 13.0 0.69 10.3 2.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4472) Glyco_transf_90 PF05686.7 KOO31753.1 - 1e-22 80.4 0.0 1.9e-22 79.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 90 DUF2730 PF10805.3 KOO31753.1 - 0.0019 17.9 8.8 0.0025 17.5 2.2 3.1 2 1 1 3 3 3 1 Protein of unknown function (DUF2730) Phage_GPO PF05929.6 KOO31753.1 - 0.0025 17.1 3.8 0.0025 17.1 2.7 2.0 1 1 1 2 2 2 1 Phage capsid scaffolding protein (GPO) serine peptidase NPV_P10 PF05531.7 KOO31753.1 - 0.0028 17.8 7.1 2.1 8.6 0.1 3.3 2 1 1 3 3 3 1 Nucleopolyhedrovirus P10 protein CK2S PF15011.1 KOO31753.1 - 0.0089 15.8 1.0 0.0089 15.8 0.7 2.5 1 1 1 2 2 2 1 Casein Kinase 2 substrate FlaC_arch PF05377.6 KOO31753.1 - 0.012 15.4 1.2 0.012 15.4 0.9 2.9 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Tropomyosin PF00261.15 KOO31753.1 - 0.024 13.7 24.3 0.016 14.2 11.2 2.1 2 0 0 2 2 2 0 Tropomyosin IncA PF04156.9 KOO31753.1 - 0.035 13.7 16.0 0.081 12.5 11.1 1.6 1 1 0 1 1 1 0 IncA protein TMF_DNA_bd PF12329.3 KOO31753.1 - 0.045 13.5 23.0 0.21 11.4 2.4 3.3 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Matrilin_ccoil PF10393.4 KOO31753.1 - 0.046 13.0 0.5 0.046 13.0 0.4 3.3 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin Baculo_PEP_C PF04513.7 KOO31753.1 - 0.052 13.3 0.3 0.11 12.2 0.0 1.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF489 PF04356.7 KOO31753.1 - 0.054 13.0 10.2 1.5 8.3 0.1 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF489) Fib_alpha PF08702.5 KOO31753.1 - 0.075 13.1 11.1 1.2 9.2 1.4 3.0 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.4 KOO31753.1 - 0.13 12.4 10.4 2.5 8.2 0.2 3.4 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Reo_sigmaC PF04582.7 KOO31753.1 - 0.2 10.8 0.6 0.29 10.2 0.4 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein AAA_13 PF13166.1 KOO31753.1 - 0.25 9.7 13.5 0.32 9.4 9.4 1.1 1 0 0 1 1 1 0 AAA domain RIC3 PF15361.1 KOO31753.1 - 0.97 9.6 7.2 3.2 7.9 0.2 2.4 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 DUF342 PF03961.8 KOO31753.1 - 0.98 7.7 15.1 0.039 12.3 4.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF342) SlyX PF04102.7 KOO31753.1 - 3 8.2 15.3 1.5 9.2 0.3 3.5 1 1 1 3 3 3 0 SlyX IATP PF04568.7 KOO31753.1 - 3 7.9 14.3 3.2 7.8 1.5 3.1 4 0 0 4 4 2 0 Mitochondrial ATPase inhibitor, IATP Occludin_ELL PF07303.8 KOO31753.1 - 3 8.6 9.5 0.48 11.1 2.0 2.3 1 1 1 2 2 2 0 Occludin homology domain V_ATPase_I PF01496.14 KOO31753.1 - 7.1 4.3 11.9 3.3 5.4 6.1 1.7 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Vps51 PF08700.6 KOO31753.1 - 8.3 6.3 7.7 8.4 6.3 0.8 2.8 2 1 1 3 3 3 0 Vps51/Vps67 Nsp1_C PF05064.8 KOO31753.1 - 9.1 5.9 12.6 3.6 7.2 0.5 3.2 2 1 1 3 3 3 0 Nsp1-like C-terminal region CALCOCO1 PF07888.6 KOO31753.1 - 9.6 4.3 18.1 25 2.9 12.5 1.6 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Pkinase PF00069.20 KOO31754.1 - 3.9e-49 167.1 0.0 5.1e-49 166.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31754.1 - 6.7e-27 94.1 0.0 8.6e-27 93.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO31754.1 - 9.5e-05 21.4 0.0 0.00014 20.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO31754.1 - 0.0063 16.2 8.9 0.12 12.0 0.0 3.2 2 1 1 3 3 3 2 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 KOO31754.1 - 0.017 14.5 0.0 0.079 12.2 0.0 1.9 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Kdo PF06293.9 KOO31754.1 - 0.25 10.3 1.0 0.42 9.6 0.7 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Nol1_Nop2_Fmu PF01189.12 KOO31756.1 - 0.033 13.5 0.0 0.081 12.2 0.0 1.6 1 1 1 2 2 2 0 NOL1/NOP2/sun family AAT PF03417.11 KOO31757.1 - 7.4e-25 87.7 0.0 1e-24 87.2 0.0 1.1 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase NAAA-beta PF15508.1 KOO31757.1 - 0.0034 17.7 0.0 0.0057 16.9 0.0 1.4 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Ceramidase PF05875.7 KOO31758.1 - 8.8e-06 25.0 0.0 1e-05 24.8 0.0 1.0 1 0 0 1 1 1 1 Ceramidase SepZ PF06066.6 KOO31758.1 - 0.051 13.5 0.1 0.07 13.1 0.1 1.3 1 1 0 1 1 1 0 SepZ CHAT PF12770.2 KOO31761.1 - 0.005 16.0 0.4 0.0057 15.8 0.3 1.1 1 0 0 1 1 1 1 CHAT domain EF-hand_1 PF00036.27 KOO31761.1 - 0.0073 15.5 0.0 0.016 14.4 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO31761.1 - 0.011 15.9 0.0 0.018 15.1 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.1 KOO31761.1 - 0.014 14.7 0.1 0.027 13.8 0.1 1.5 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.1 KOO31761.1 - 0.028 14.2 0.0 0.063 13.1 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain Penicillinase_R PF03965.11 KOO31761.1 - 0.14 12.2 2.1 0.5 10.4 1.3 1.8 1 1 1 2 2 2 0 Penicillinase repressor HEAT PF02985.17 KOO31762.1 - 5.6e-10 38.4 19.3 0.62 10.2 0.0 9.7 9 0 0 9 9 9 3 HEAT repeat HEAT_2 PF13646.1 KOO31762.1 - 1.8e-08 34.5 33.8 0.0072 16.5 2.9 7.1 4 2 4 9 9 9 7 HEAT repeats HEAT_EZ PF13513.1 KOO31762.1 - 1.4e-05 25.3 57.7 0.0011 19.3 0.6 9.4 10 2 2 12 12 12 5 HEAT-like repeat CLASP_N PF12348.3 KOO31762.1 - 3.7e-05 23.1 0.0 2.3 7.5 0.0 4.2 3 2 1 4 4 4 2 CLASP N terminal Cnd1 PF12717.2 KOO31762.1 - 4.2e-05 23.4 0.0 0.0061 16.4 0.0 3.9 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Ipi1_N PF12333.3 KOO31762.1 - 8.8e-05 22.4 2.5 0.41 10.6 0.0 4.0 4 0 0 4 4 4 2 Rix1 complex component involved in 60S ribosome maturation Adaptin_N PF01602.15 KOO31762.1 - 0.00013 20.4 0.7 0.0071 14.7 0.1 2.7 3 0 0 3 3 3 1 Adaptin N terminal region ParcG PF10274.4 KOO31762.1 - 0.005 16.7 0.0 0.021 14.7 0.0 1.9 2 0 0 2 2 2 1 Parkin co-regulated protein Arm PF00514.18 KOO31762.1 - 0.031 14.1 18.1 3.4 7.6 0.2 8.0 9 0 0 9 9 9 0 Armadillo/beta-catenin-like repeat MMS19_N PF14500.1 KOO31762.1 - 0.074 12.2 0.1 6.1 6.0 0.0 2.9 3 0 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II Ribosomal_S30AE PF02482.14 KOO31763.1 - 4.6e-13 49.4 1.1 7.1e-13 48.8 0.8 1.2 1 0 0 1 1 1 1 Sigma 54 modulation protein / S30EA ribosomal protein CagA PF03507.8 KOO31763.1 - 0.012 15.4 0.1 0.02 14.7 0.1 1.4 1 1 0 1 1 1 0 CagA exotoxin Striatin PF08232.7 KOO31763.1 - 0.063 13.5 0.3 0.097 12.9 0.2 1.2 1 0 0 1 1 1 0 Striatin family Phage_Gp23 PF10669.4 KOO31763.1 - 0.073 13.1 0.9 5.3 7.1 0.3 2.2 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) Cortex-I_coil PF09304.5 KOO31763.1 - 0.1 12.6 2.9 0.13 12.2 1.4 1.5 1 1 0 1 1 1 0 Cortexillin I, coiled coil Pkinase PF00069.20 KOO31764.1 - 2.9e-60 203.6 0.0 4.3e-60 203.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31764.1 - 7.1e-39 133.4 0.0 1.1e-38 132.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO31764.1 - 8.4e-06 24.9 0.0 3.1e-05 23.0 0.0 1.8 2 0 0 2 2 2 1 Kinase-like GreA_GreB PF01272.14 KOO31764.1 - 0.075 12.7 0.1 4.9 6.9 0.0 2.3 2 0 0 2 2 2 0 Transcription elongation factor, GreA/GreB, C-term Peptidase_M55 PF04951.8 KOO31764.1 - 0.13 11.4 0.0 14 4.7 0.0 2.3 2 0 0 2 2 2 0 D-aminopeptidase Seadorna_VP7 PF07387.6 KOO31764.1 - 0.29 9.9 0.0 0.46 9.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 DUF2431 PF10354.4 KOO31765.1 - 1.2e-06 28.5 0.0 1.8e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) Methyltransf_26 PF13659.1 KOO31765.1 - 0.065 13.2 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Tudor-knot PF11717.3 KOO31766.1 - 0.085 12.5 3.1 13 5.5 0.0 2.7 2 1 0 2 2 2 0 RNA binding activity-knot of a chromodomain Pkinase PF00069.20 KOO31767.1 - 5.9e-37 127.2 0.0 9.5e-37 126.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31767.1 - 5.7e-35 120.6 0.0 1.7e-34 119.0 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Mito_carr PF00153.22 KOO31768.1 - 5e-24 83.8 3.8 1.6e-18 66.2 0.1 2.6 2 1 0 2 2 2 2 Mitochondrial carrier protein SHIPPO-rpt PF07004.7 KOO31769.1 - 1.8e-05 25.3 3.0 11 7.0 0.0 5.1 4 0 0 4 4 4 3 Sperm-tail PG-rich repeat RPA_C PF08784.6 KOO31770.1 - 2.3e-09 37.5 0.3 8.8e-09 35.7 0.0 2.1 2 0 0 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.20 KOO31770.1 - 7.7e-08 32.0 0.0 1.3e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Ten1_2 PF15490.1 KOO31770.1 - 0.055 13.0 0.0 0.13 11.8 0.0 1.7 1 1 0 1 1 1 0 Telomere-capping, CST complex subunit ABC_tran PF00005.22 KOO31771.1 - 1.2e-34 119.5 0.0 2.5e-34 118.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 KOO31771.1 - 3.3e-26 92.3 12.5 6e-26 91.4 8.6 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.14 KOO31771.1 - 3.1e-06 26.5 2.1 4.9e-05 22.6 0.2 2.1 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 KOO31771.1 - 0.00027 21.0 0.2 0.0025 17.9 0.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 KOO31771.1 - 0.00047 19.6 0.0 0.0012 18.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.1 KOO31771.1 - 0.00056 19.9 0.2 0.0013 18.7 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.1 KOO31771.1 - 0.00062 19.2 0.4 0.0017 17.8 0.3 1.6 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.1 KOO31771.1 - 0.00079 19.4 0.0 0.24 11.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 KOO31771.1 - 0.00087 19.5 0.2 0.04 14.1 0.1 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 KOO31771.1 - 0.0073 17.1 0.0 0.017 15.9 0.0 1.6 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 KOO31771.1 - 0.0086 15.2 0.0 0.016 14.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 IstB_IS21 PF01695.12 KOO31771.1 - 0.01 15.2 0.5 4.1 6.7 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein DUF87 PF01935.12 KOO31771.1 - 0.017 14.9 0.4 0.067 13.0 0.3 2.0 1 1 0 1 1 1 0 Domain of unknown function DUF87 AAA_33 PF13671.1 KOO31771.1 - 0.029 14.2 0.0 0.057 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 KOO31771.1 - 0.047 12.7 0.0 0.096 11.7 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.7 KOO31771.1 - 0.048 13.3 0.1 0.9 9.1 0.0 2.3 2 0 0 2 2 2 0 NACHT domain DUF815 PF05673.8 KOO31771.1 - 0.086 11.7 0.0 0.15 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_14 PF13173.1 KOO31771.1 - 0.099 12.5 0.0 1.7 8.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 KOO31771.1 - 0.11 11.9 0.4 0.28 10.5 0.1 1.8 2 0 0 2 2 2 0 AAA-like domain AAA_5 PF07728.9 KOO31771.1 - 0.11 12.2 0.1 10 5.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) SbcCD_C PF13558.1 KOO31771.1 - 0.31 10.9 4.2 0.45 10.4 0.3 3.2 3 1 0 3 3 3 0 Putative exonuclease SbcCD, C subunit DUF4131 PF13567.1 KOO31771.1 - 7.1 6.0 8.0 2.3 7.6 1.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) SAA PF00277.13 KOO31772.1 - 0.043 14.1 0.3 0.091 13.1 0.2 1.5 1 0 0 1 1 1 0 Serum amyloid A protein Acid_PPase PF12689.2 KOO31774.1 - 3.4e-19 69.0 0.0 8.4e-19 67.8 0.0 1.6 1 0 0 1 1 1 1 Acid Phosphatase Ribonuclease_3 PF00636.21 KOO31774.1 - 3.2e-17 63.0 0.0 3.6e-09 37.0 0.0 2.9 2 0 0 2 2 2 2 Ribonuclease III domain DEAD PF00270.24 KOO31774.1 - 9.4e-16 57.7 0.0 3.2e-15 56.0 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO31774.1 - 1.3e-13 50.5 0.1 1.4e-12 47.3 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO31774.1 - 4.3e-11 42.9 0.0 8.9e-10 38.6 0.0 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Ribonucleas_3_3 PF14622.1 KOO31774.1 - 4.4e-06 26.6 0.0 0.061 13.2 0.0 3.8 5 0 0 5 5 5 2 Ribonuclease-III-like CS PF04969.11 KOO31775.1 - 6.7e-11 42.5 0.0 1.1e-10 41.8 0.0 1.4 1 0 0 1 1 1 1 CS domain fn3 PF00041.16 KOO31775.1 - 1.1e-06 28.6 2.2 7.1e-05 22.8 0.8 3.0 2 1 0 2 2 2 1 Fibronectin type III domain Branch PF02485.16 KOO31776.1 - 0.045 12.9 0.0 0.052 12.6 0.0 1.2 1 0 0 1 1 1 0 Core-2/I-Branching enzyme Leuk-A4-hydro_C PF09127.6 KOO31778.1 - 0.042 13.4 0.3 0.058 12.9 0.2 1.2 1 0 0 1 1 1 0 Leukotriene A4 hydrolase, C-terminal YABBY PF04690.8 KOO31779.1 - 1.3e-08 35.3 0.1 1.5e-08 35.1 0.1 1.1 1 0 0 1 1 1 1 YABBY protein HMG_box PF00505.14 KOO31779.1 - 1.6e-05 25.0 0.6 2.5e-05 24.4 0.0 1.6 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO31779.1 - 6.6e-05 23.1 0.5 0.0002 21.6 0.0 1.8 2 0 0 2 2 2 1 HMG-box domain MFS_2 PF13347.1 KOO31784.1 - 1.9e-14 52.9 3.4 2.2e-14 52.7 2.4 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein Arm PF00514.18 KOO31785.1 - 1.4e-157 506.9 157.9 5.4e-06 26.0 0.4 44.3 44 1 1 45 45 45 39 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 KOO31785.1 - 5e-11 42.1 10.8 0.017 14.1 0.5 9.7 7 2 4 11 11 11 3 Armadillo-like EF-hand_5 PF13202.1 KOO31785.1 - 1.3e-08 33.7 0.7 0.0012 18.1 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.27 KOO31785.1 - 1.7e-08 33.1 0.1 0.0048 16.1 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO31785.1 - 3.4e-07 29.5 0.2 0.0034 17.1 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain Atx10homo_assoc PF09759.4 KOO31785.1 - 5e-07 29.3 6.5 0.07 12.8 0.2 7.8 8 0 0 8 8 8 2 Spinocerebellar ataxia type 10 protein domain EF-hand_7 PF13499.1 KOO31785.1 - 1.5e-06 28.2 0.0 0.065 13.3 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO31785.1 - 1.9e-06 27.3 0.0 4.6e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair V-ATPase_H_N PF03224.9 KOO31785.1 - 0.00058 19.0 2.5 2.6 7.0 0.1 6.3 5 1 2 7 7 7 1 V-ATPase subunit H Adaptin_N PF01602.15 KOO31785.1 - 0.0012 17.3 7.0 0.15 10.3 0.2 3.9 3 1 0 3 3 3 2 Adaptin N terminal region KAP PF05804.7 KOO31785.1 - 0.0048 14.8 0.0 1.7 6.4 0.0 4.6 7 0 0 7 7 7 1 Kinesin-associated protein (KAP) V-ATPase_H_C PF11698.3 KOO31785.1 - 0.079 12.8 4.0 3.3 7.6 0.1 4.9 5 0 0 5 5 5 0 V-ATPase subunit H E3_UbLigase_R4 PF13764.1 KOO31785.1 - 0.46 8.3 4.3 0.59 7.9 0.2 2.9 4 0 0 4 4 4 0 E3 ubiquitin-protein ligase UBR4 DUF3361 PF11841.3 KOO31785.1 - 3.6 7.2 18.0 2 8.1 0.0 6.3 7 0 0 7 7 7 0 Domain of unknown function (DUF3361) GETHR PF05671.6 KOO31786.1 - 0.017 14.2 0.8 0.029 13.5 0.6 1.4 1 0 0 1 1 1 0 GETHR pentapeptide repeat (5 copies) DUF4235 PF14019.1 KOO31786.1 - 0.062 13.1 0.1 0.15 11.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4235) RF-1 PF00472.15 KOO31787.1 - 1e-05 25.2 1.7 1.4e-05 24.8 1.2 1.3 1 0 0 1 1 1 1 RF-1 domain FlgN PF05130.7 KOO31787.1 - 0.051 13.8 2.1 0.064 13.4 1.4 1.1 1 0 0 1 1 1 0 FlgN protein Pkinase PF00069.20 KOO31788.1 - 2.8e-72 242.9 0.0 3.3e-72 242.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31788.1 - 4.3e-30 104.6 0.0 5.4e-30 104.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO31788.1 - 6.6e-08 32.5 0.5 0.0007 19.3 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO31788.1 - 1.8e-06 27.1 0.0 3.4e-05 22.9 0.0 2.1 1 1 0 2 2 2 1 Kinase-like Kdo PF06293.9 KOO31788.1 - 1.5e-05 24.1 0.0 2.6e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 KOO31788.1 - 0.0014 18.2 0.0 0.0022 17.6 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase YrbL-PhoP_reg PF10707.4 KOO31788.1 - 0.014 14.7 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DUF1679 PF07914.6 KOO31788.1 - 0.022 13.4 0.0 0.035 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) DUF4431 PF14485.1 KOO31789.1 - 0.083 12.5 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4431) Transposase_22 PF02994.9 KOO31790.1 - 0.11 11.0 5.0 0.12 10.8 3.5 1.1 1 0 0 1 1 1 0 L1 transposable element IFT57 PF10498.4 KOO31790.1 - 2.7 6.6 9.0 3.2 6.4 6.2 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Nup88 PF10168.4 KOO31790.1 - 2.8 5.6 8.2 3.9 5.2 5.7 1.2 1 0 0 1 1 1 0 Nuclear pore component GDE_C PF06202.9 KOO31790.1 - 6.2 5.4 6.8 7.8 5.1 4.7 1.1 1 0 0 1 1 1 0 Amylo-alpha-1,6-glucosidase BCDHK_Adom3 PF10436.4 KOO31791.1 - 1.2e-12 47.6 0.2 1.7e-12 47.1 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase DUF563 PF04577.9 KOO31795.1 - 3.6e-10 40.0 0.0 6.6e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF563) DHDPS PF00701.17 KOO31796.1 - 1.5e-24 86.0 0.0 2e-24 85.6 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Amidohydro_2 PF04909.9 KOO31796.1 - 0.00027 20.5 0.1 0.0007 19.2 0.0 1.6 2 0 0 2 2 2 1 Amidohydrolase Ank PF00023.25 KOO31797.1 - 1.8e-13 49.5 1.1 1.4e-06 27.7 0.1 2.9 2 1 1 3 3 3 2 Ankyrin repeat Ank_2 PF12796.2 KOO31797.1 - 3.7e-11 43.2 0.0 7.4e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO31797.1 - 4.1e-08 33.5 0.1 2.6e-07 30.9 0.1 2.3 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO31797.1 - 3.1e-06 27.2 0.3 0.056 13.7 0.1 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO31797.1 - 6.6e-06 25.8 0.5 0.035 14.3 0.1 2.9 3 0 0 3 3 3 2 Ankyrin repeat WD40 PF00400.27 KOO31798.1 - 2.7e-39 131.6 11.3 3.3e-10 39.4 0.0 6.5 7 0 0 7 7 7 5 WD domain, G-beta repeat CAF1C_H4-bd PF12265.3 KOO31798.1 - 1.2e-30 105.1 0.2 2.9e-30 103.9 0.1 1.7 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex eIF2A PF08662.6 KOO31798.1 - 0.00016 21.4 1.5 0.0038 16.9 0.0 2.9 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A DUF1995 PF09353.5 KOO31799.1 - 2.8e-29 102.2 0.0 3.7e-29 101.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1995) Aminotran_3 PF00202.16 KOO31801.1 - 4.7e-98 328.1 0.6 5.6e-98 327.9 0.4 1.1 1 0 0 1 1 1 1 Aminotransferase class-III zf-H2C2_2 PF13465.1 KOO31802.1 - 6.2e-34 114.6 55.0 5e-07 29.6 1.0 8.2 8 0 0 8 8 8 5 Zinc-finger double domain zf-C2H2 PF00096.21 KOO31802.1 - 4.3e-30 102.2 58.1 4.6e-05 23.5 1.5 7.4 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOO31802.1 - 1e-23 81.8 44.7 0.00068 19.7 0.3 7.5 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_6 PF13912.1 KOO31802.1 - 1.3e-05 24.8 31.2 0.3 11.0 0.1 7.2 7 0 0 7 7 7 4 C2H2-type zinc finger zf-RING_2 PF13639.1 KOO31802.1 - 0.0016 18.2 0.7 0.0016 18.2 0.5 3.8 2 1 2 4 4 4 1 Ring finger domain FANCL_C PF11793.3 KOO31802.1 - 0.071 13.0 0.7 0.071 13.0 0.5 7.8 2 2 6 8 8 8 0 FANCL C-terminal domain Zn-ribbon_8 PF09723.5 KOO31802.1 - 0.68 9.9 26.6 27 4.7 0.0 7.3 7 0 0 7 7 7 0 Zinc ribbon domain CHORD PF04968.7 KOO31802.1 - 1.8 8.8 36.8 5 7.4 0.3 6.5 1 1 5 6 6 6 0 CHORD zf-C2H2_jaz PF12171.3 KOO31802.1 - 3.3 7.9 35.3 0.69 10.1 2.6 7.1 7 0 0 7 7 7 0 Zinc-finger double-stranded RNA-binding DUF179 PF02622.10 KOO31807.1 - 1.8e-21 76.4 0.0 4.6e-20 71.8 0.0 2.2 1 1 0 1 1 1 1 Uncharacterized ACR, COG1678 TPR_11 PF13414.1 KOO31808.1 - 2.6e-31 107.0 18.3 3.6e-14 52.1 0.1 3.6 3 0 0 3 3 3 3 TPR repeat TPR_2 PF07719.12 KOO31808.1 - 1.8e-21 74.2 19.0 7.6e-06 25.4 0.2 6.0 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_1 PF00515.23 KOO31808.1 - 3.7e-21 73.7 7.7 1.6e-07 30.5 0.1 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOO31808.1 - 5.9e-13 48.5 12.0 1.5e-05 24.7 1.4 4.2 2 2 1 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO31808.1 - 5.6e-11 42.7 41.5 6.6e-06 26.6 1.3 4.6 4 1 0 4 4 3 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO31808.1 - 6.3e-10 38.1 2.3 0.16 11.8 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO31808.1 - 3.9e-07 29.3 5.2 0.025 14.3 0.1 5.2 4 1 1 5 5 5 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO31808.1 - 4.3e-07 29.6 0.3 0.00024 20.9 0.1 4.1 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.1 KOO31808.1 - 4.8e-06 26.3 19.1 2.8e-05 23.8 1.7 5.2 2 2 3 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO31808.1 - 0.00035 20.8 22.7 0.032 14.5 3.4 5.0 2 2 3 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.1 KOO31808.1 - 0.0014 19.1 35.2 0.02 15.4 0.6 7.1 2 2 6 8 8 7 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO31808.1 - 0.0015 18.5 3.1 3.3 8.1 0.0 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.1 KOO31808.1 - 0.0021 17.9 19.4 0.76 9.7 0.4 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat MIT PF04212.13 KOO31808.1 - 0.0043 16.8 4.8 0.32 10.9 0.7 3.7 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain Apc3 PF12895.2 KOO31808.1 - 0.0088 16.1 4.4 6 7.0 0.0 3.9 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF3856 PF12968.2 KOO31808.1 - 0.091 12.5 15.3 0.11 12.3 0.4 5.1 3 2 1 4 4 4 0 Domain of Unknown Function (DUF3856) TPR_4 PF07721.9 KOO31808.1 - 0.18 12.3 0.1 0.18 12.3 0.1 7.2 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_3 PF07720.7 KOO31808.1 - 0.74 9.6 5.2 4.8 7.0 0.4 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO31808.1 - 1.8 9.2 13.9 16 6.2 0.0 5.3 5 1 0 5 5 4 0 Tetratricopeptide repeat LRR_6 PF13516.1 KOO31809.1 - 5.2e-49 158.8 22.8 0.00024 20.8 0.0 12.3 12 0 0 12 12 12 10 Leucine Rich repeat LRR_4 PF12799.2 KOO31809.1 - 4.6e-09 35.6 7.3 2.6 7.7 0.0 7.4 5 3 2 7 7 7 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO31809.1 - 1.4e-07 30.5 1.5 95 3.6 0.0 8.7 9 1 0 9 9 9 0 Leucine Rich Repeat SpoU_sub_bind PF08032.7 KOO31809.1 - 6.6e-05 23.0 11.0 12 6.1 0.0 6.4 6 0 0 6 6 6 1 RNA 2'-O ribose methyltransferase substrate binding CbiG_N PF11760.3 KOO31809.1 - 0.82 9.4 29.8 1 9.1 1.3 7.2 6 2 2 8 8 8 0 Cobalamin synthesis G N-terminal MR_MLE_C PF13378.1 KOO31809.1 - 1.7 8.6 5.5 21 5.1 0.1 3.5 1 1 2 3 3 3 0 Enolase C-terminal domain-like ABC_tran PF00005.22 KOO31810.1 - 7.1e-25 87.8 0.0 1.2e-24 87.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 KOO31810.1 - 3.1e-09 36.6 3.2 9.9e-09 34.9 1.4 2.2 1 1 1 2 2 2 1 ABC transporter transmembrane region AAA_16 PF13191.1 KOO31810.1 - 5.1e-05 23.3 1.3 8.1e-05 22.6 0.1 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.1 KOO31810.1 - 0.00011 21.6 0.1 0.0014 18.1 0.1 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.1 KOO31810.1 - 0.0055 16.8 0.0 0.04 14.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 KOO31810.1 - 0.014 14.8 0.0 0.031 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.14 KOO31810.1 - 0.029 13.6 0.5 2.1 7.5 0.0 2.2 1 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 KOO31810.1 - 0.03 14.2 0.0 0.14 12.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 KOO31810.1 - 0.056 14.2 0.0 0.12 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 KOO31810.1 - 0.19 12.0 0.0 0.45 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Methyltransf_26 PF13659.1 KOO31811.1 - 0.027 14.5 2.9 0.057 13.4 0.3 2.4 2 1 0 2 2 2 0 Methyltransferase domain Transglycosylas PF06737.9 KOO31811.1 - 0.041 14.1 0.2 0.096 12.9 0.0 1.7 2 0 0 2 2 2 0 Transglycosylase-like domain DNA_methylase PF00145.12 KOO31811.1 - 0.15 11.1 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase LRV PF01816.12 KOO31811.1 - 6.4 7.1 10.4 3.4 8.0 1.4 3.4 2 1 0 2 2 2 0 Leucine rich repeat variant PP2C PF00481.16 KOO31813.1 - 6.3e-52 176.4 0.0 8e-52 176.1 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 KOO31813.1 - 3.5e-06 26.5 0.3 1.1e-05 24.9 0.2 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C Ank_2 PF12796.2 KOO31814.1 - 2.1e-61 204.2 42.2 1.8e-16 60.2 1.0 6.4 3 2 4 7 7 7 7 Ankyrin repeats (3 copies) Ank PF00023.25 KOO31814.1 - 1.4e-35 119.3 34.1 1.8e-05 24.3 0.0 11.5 11 0 0 11 11 11 8 Ankyrin repeat Ank_4 PF13637.1 KOO31814.1 - 6.2e-29 99.8 12.4 2.8e-09 37.2 0.1 7.7 5 3 3 9 9 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO31814.1 - 7.7e-28 95.8 29.0 3.6e-05 23.8 0.3 9.5 5 3 4 9 9 9 7 Ankyrin repeats (many copies) Chorein_N PF12624.2 KOO31814.1 - 2.5e-26 91.5 0.0 4.6e-26 90.6 0.0 1.4 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter Ank_3 PF13606.1 KOO31814.1 - 2.3e-20 70.6 18.0 0.0076 16.4 0.0 10.2 10 0 0 10 10 10 6 Ankyrin repeat DUF1162 PF06650.7 KOO31814.1 - 6.6e-10 38.6 0.0 0.00014 21.1 0.0 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF1162) EF-hand_1 PF00036.27 KOO31814.1 - 8.6e-07 27.8 0.0 0.0018 17.4 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO31814.1 - 1.6e-05 24.9 0.0 9.4e-05 22.4 0.0 2.3 1 1 0 1 1 1 1 EF-hand domain pair ATG_C PF09333.6 KOO31814.1 - 2.3e-05 24.4 0.7 0.00022 21.3 0.0 3.1 3 0 0 3 3 2 1 ATG C terminal domain EF-hand_5 PF13202.1 KOO31814.1 - 7.2e-05 21.9 0.0 0.00025 20.2 0.0 2.0 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO31814.1 - 0.00039 20.0 0.1 0.04 13.8 0.0 2.8 2 0 0 2 2 2 1 EF-hand domain PH PF00169.24 KOO31814.1 - 0.0061 16.7 0.0 0.014 15.5 0.0 1.6 1 0 0 1 1 1 1 PH domain EF-hand_8 PF13833.1 KOO31814.1 - 0.1 12.2 0.2 1.1 8.9 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain pair Apt1 PF10351.4 KOO31814.1 - 0.13 11.1 0.0 0.28 9.9 0.0 1.5 1 0 0 1 1 1 0 Golgi-body localisation protein domain zf-C3HC4_3 PF13920.1 KOO31815.1 - 0.43 10.2 5.0 0.28 10.8 1.6 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Rotamase PF00639.16 KOO31816.1 - 1.9e-20 73.4 0.1 3.3e-13 50.1 0.0 2.3 1 1 1 2 2 2 2 PPIC-type PPIASE domain Rotamase_3 PF13616.1 KOO31816.1 - 4.8e-15 55.8 0.3 6.9e-10 39.2 0.1 2.4 1 1 1 2 2 2 2 PPIC-type PPIASE domain Rotamase_2 PF13145.1 KOO31816.1 - 2.9e-05 24.7 0.1 7.8e-05 23.2 0.0 1.6 1 1 0 1 1 1 1 PPIC-type PPIASE domain SNase PF00565.12 KOO31819.1 - 3.3e-57 191.3 0.0 8.2e-17 61.4 0.0 5.2 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.19 KOO31819.1 - 7.1e-24 83.9 0.0 1.3e-23 83.1 0.0 1.4 1 0 0 1 1 1 1 Tudor domain Cnd1 PF12717.2 KOO31820.1 - 1.8e-35 122.3 0.0 1.9e-31 109.2 0.0 4.3 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.2 KOO31820.1 - 1.4e-10 41.1 2.8 3.6e-10 39.7 0.0 2.9 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT PF02985.17 KOO31820.1 - 1.5e-06 27.7 1.6 0.5 10.5 0.2 6.0 5 0 0 5 5 5 1 HEAT repeat Adaptin_N PF01602.15 KOO31820.1 - 0.0001 20.8 0.1 0.02 13.2 0.2 3.5 3 1 1 4 4 4 1 Adaptin N terminal region HEAT_2 PF13646.1 KOO31820.1 - 0.00078 19.6 18.8 0.066 13.4 1.6 6.1 4 2 3 7 7 7 3 HEAT repeats Cnd3 PF12719.2 KOO31820.1 - 0.0055 15.7 0.1 0.023 13.7 0.0 2.1 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain SAPS PF04499.10 KOO31820.1 - 0.0073 14.9 1.4 0.35 9.4 0.5 2.8 3 0 0 3 3 3 1 SIT4 phosphatase-associated protein mRNA_stabil PF13929.1 KOO31820.1 - 0.018 14.0 0.0 0.062 12.2 0.0 1.8 2 0 0 2 2 2 0 mRNA stabilisation PAP_fibrillin PF04755.7 KOO31821.1 - 9.4e-09 35.2 0.0 1.9e-08 34.2 0.0 1.5 1 1 0 1 1 1 1 PAP_fibrillin Exostosin PF03016.10 KOO31822.1 - 3.3e-09 36.2 0.1 3.9e-07 29.4 0.0 2.8 3 0 0 3 3 3 2 Exostosin family EGF_2 PF07974.8 KOO31822.1 - 0.0079 16.3 12.8 0.019 15.1 8.9 1.7 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.22 KOO31822.1 - 0.53 10.3 8.2 1.3 9.0 5.7 1.7 1 0 0 1 1 1 0 EGF-like domain WD40 PF00400.27 KOO31823.1 - 3.3e-08 33.1 0.5 0.005 16.6 0.0 5.4 5 0 0 5 5 5 1 WD domain, G-beta repeat Clathrin PF00637.15 KOO31823.1 - 2.2e-07 30.5 0.1 0.00067 19.2 0.0 3.9 3 1 1 4 4 4 1 Region in Clathrin and VPS Coatomer_WDAD PF04053.9 KOO31823.1 - 3.3e-05 22.8 8.8 0.0033 16.2 0.0 3.4 1 1 2 3 3 3 2 Coatomer WD associated region TPR_11 PF13414.1 KOO31823.1 - 0.0075 15.8 17.1 0.0093 15.5 0.2 5.0 4 1 0 4 4 4 1 TPR repeat TPR_12 PF13424.1 KOO31823.1 - 0.021 14.7 11.4 0.27 11.1 0.0 5.0 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO31823.1 - 0.026 14.4 16.0 1.1 9.3 0.3 7.0 6 1 1 7 7 7 0 Tetratricopeptide repeat eIF2A PF08662.6 KOO31823.1 - 0.035 13.8 0.1 0.12 12.0 0.0 1.9 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A TPR_1 PF00515.23 KOO31823.1 - 0.064 12.8 6.7 4.5 7.0 0.2 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat DZR PF12773.2 KOO31823.1 - 0.074 12.8 10.4 0.059 13.1 5.0 2.4 2 1 0 2 2 1 0 Double zinc ribbon FlhC PF05280.6 KOO31823.1 - 0.13 11.7 0.6 0.29 10.5 0.4 1.5 1 0 0 1 1 1 0 Flagellar transcriptional activator (FlhC) PD40 PF07676.7 KOO31823.1 - 0.16 11.6 0.4 4.1 7.1 0.2 2.5 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat PPR PF01535.15 KOO31823.1 - 0.68 10.0 4.8 1.9 8.6 0.1 4.0 5 1 0 5 5 3 0 PPR repeat zf-ribbon_3 PF13248.1 KOO31823.1 - 1.6 8.0 6.8 1.2 8.4 2.9 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Chlam_OMP3 PF03503.8 KOO31823.1 - 3.4 7.9 8.9 0.42 10.8 2.9 2.0 2 0 0 2 2 1 0 Chlamydia cysteine-rich outer membrane protein 3 Catalase-rel PF06628.7 KOO31824.1 - 0.015 15.1 0.0 0.037 13.8 0.0 1.6 1 0 0 1 1 1 0 Catalase-related immune-responsive TruB_C PF09142.6 KOO31824.1 - 1.8 8.2 6.0 12 5.6 0.1 2.4 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal SecY PF00344.15 KOO31825.1 - 8.2e-97 324.2 9.8 1.1e-96 323.8 6.8 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.4 KOO31825.1 - 2.6e-17 62.0 0.0 1e-16 60.1 0.0 2.1 1 0 0 1 1 1 1 Plug domain of Sec61p Phage_holin_1 PF04531.8 KOO31825.1 - 0.3 11.1 1.9 20 5.3 0.0 3.7 4 0 0 4 4 4 0 Bacteriophage holin Pkinase PF00069.20 KOO31826.1 - 8.1e-58 195.6 0.0 9.6e-58 195.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31826.1 - 5.7e-36 123.9 0.0 6.8e-36 123.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO31826.1 - 7.6e-07 28.3 0.0 0.0028 16.6 0.0 2.5 3 0 0 3 3 3 2 Kinase-like APH PF01636.18 KOO31826.1 - 0.051 13.2 0.1 0.086 12.5 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 KOO31826.1 - 0.087 11.8 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2036 PF09724.4 KOO31827.1 - 7e-60 202.8 0.0 8.5e-60 202.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2036) NACHT PF05729.7 KOO31828.1 - 0.00015 21.4 0.1 0.00044 19.9 0.0 1.8 1 1 0 1 1 1 1 NACHT domain AAA_25 PF13481.1 KOO31828.1 - 0.00051 19.4 0.2 0.0012 18.3 0.2 1.6 1 0 0 1 1 1 1 AAA domain RRM_1 PF00076.17 KOO31828.1 - 0.0058 16.2 0.0 0.015 14.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO31828.1 - 0.0079 16.1 0.0 0.026 14.4 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO31828.1 - 0.065 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TIR_2 PF13676.1 KOO31829.1 - 0.001 19.1 0.0 0.0023 18.0 0.0 1.6 1 0 0 1 1 1 1 TIR domain DUF1863 PF08937.6 KOO31829.1 - 0.0058 16.6 0.0 0.084 12.9 0.0 2.4 1 1 0 1 1 1 1 MTH538 TIR-like domain (DUF1863) TRAM_LAG1_CLN8 PF03798.11 KOO31830.1 - 8.9e-14 51.4 9.3 1.2e-13 51.0 6.4 1.2 1 0 0 1 1 1 1 TLC domain SAP PF02037.22 KOO31831.1 - 3.2e-09 36.0 2.2 1e-08 34.4 1.5 2.0 1 0 0 1 1 1 1 SAP domain Arm PF00514.18 KOO31831.1 - 0.023 14.5 0.3 0.68 9.8 0.0 3.5 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Chromo PF00385.19 KOO31832.1 - 1.6e-12 46.9 0.9 7.3e-12 44.7 0.5 2.3 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Sigma70_r4_2 PF08281.7 KOO31832.1 - 0.012 15.0 0.0 2.8 7.4 0.1 3.2 3 0 0 3 3 3 0 Sigma-70, region 4 HTH_10 PF04967.7 KOO31832.1 - 0.12 12.0 2.3 0.11 12.0 0.2 2.0 2 0 0 2 2 2 0 HTH DNA binding domain DNA_pol_viral_C PF00336.13 KOO31833.1 - 2.2e-05 23.8 0.1 3.2e-05 23.3 0.1 1.3 1 1 0 1 1 1 1 DNA polymerase (viral) C-terminal domain GvpG PF05120.7 KOO31834.1 - 0.05 13.4 7.9 4.2 7.2 0.0 3.9 4 0 0 4 4 4 0 Gas vesicle protein G MpPF1 PF07668.6 KOO31834.1 - 0.076 12.1 0.3 0.47 9.5 0.2 1.9 1 1 0 1 1 1 0 M penetrans paralogue family 1 CheR PF01739.13 KOO31835.1 - 3.7e-09 36.1 0.0 5.4e-08 32.3 0.0 2.2 1 1 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_18 PF12847.2 KOO31835.1 - 0.0033 17.9 1.1 0.0058 17.1 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO31835.1 - 0.011 16.0 0.0 0.025 14.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain OmpH PF03938.9 KOO31835.1 - 7.9 6.4 7.8 15 5.5 5.4 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) P34-Arc PF04045.9 KOO31837.1 - 1.5e-45 155.3 0.0 1.8e-44 151.8 0.0 1.9 1 1 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc EspB PF05802.6 KOO31839.1 - 0.0034 16.3 0.9 0.0035 16.3 0.6 1.0 1 0 0 1 1 1 1 Enterobacterial EspB protein IF-2B PF01008.12 KOO31839.1 - 0.0056 15.7 0.1 0.0065 15.4 0.1 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family MxiH PF09392.5 KOO31839.1 - 0.02 15.4 0.2 0.027 15.0 0.1 1.2 1 0 0 1 1 1 0 Type III secretion needle MxiH like CorA PF01544.13 KOO31839.1 - 0.027 13.5 0.0 0.028 13.4 0.0 1.0 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Baculo_PEP_C PF04513.7 KOO31839.1 - 0.1 12.4 0.5 0.12 12.1 0.4 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus MCPsignal PF00015.16 KOO31839.1 - 0.1 12.1 3.1 0.12 11.8 2.1 1.0 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain TPR_11 PF13414.1 KOO31841.1 - 1.1e-08 34.5 5.4 1.7e-07 30.7 0.1 2.7 2 0 0 2 2 2 2 TPR repeat Aha1_N PF09229.6 KOO31841.1 - 0.00017 21.4 0.0 0.00039 20.2 0.0 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal TPR_12 PF13424.1 KOO31841.1 - 0.001 18.9 5.1 0.0069 16.2 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO31841.1 - 0.0043 16.6 0.3 7.8 6.2 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO31841.1 - 0.016 15.0 9.2 1.8 8.6 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat EF-hand_1 PF00036.27 KOO31842.1 - 2e-07 29.7 0.7 3.5e-07 29.0 0.5 1.4 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO31842.1 - 3e-06 26.6 0.2 6.2e-06 25.6 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 KOO31842.1 - 1.4e-05 25.0 0.3 1.8e-05 24.8 0.2 1.3 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO31842.1 - 0.0004 19.9 0.4 0.00087 18.8 0.3 1.6 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO31842.1 - 0.1 11.9 1.9 0.25 10.7 0.9 2.0 1 1 1 2 2 2 0 EF hand EF-hand_1 PF00036.27 KOO31843.1 - 4.8e-05 22.3 0.0 9.9e-05 21.3 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO31843.1 - 0.00021 20.8 0.0 0.00043 19.9 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 KOO31843.1 - 0.0006 19.9 0.0 0.00068 19.7 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO31843.1 - 0.049 12.9 0.0 0.089 12.1 0.0 1.4 1 0 0 1 1 1 0 EF hand EF-hand_8 PF13833.1 KOO31843.1 - 0.085 12.4 0.1 0.75 9.4 0.0 2.1 1 1 1 2 2 2 0 EF-hand domain pair Sel1 PF08238.7 KOO31844.1 - 2.6e-29 100.9 14.5 2.6e-11 43.7 0.2 4.0 4 0 0 4 4 4 3 Sel1 repeat TPR_6 PF13174.1 KOO31844.1 - 0.0015 18.8 6.7 1 9.9 0.0 4.3 3 1 0 3 3 3 2 Tetratricopeptide repeat DUF3275 PF11679.3 KOO31844.1 - 0.016 14.8 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) zf-C3HC4_4 PF15227.1 KOO31845.1 - 1.5e-07 31.1 0.4 3.7e-07 29.9 0.3 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 KOO31845.1 - 3.9e-07 29.9 2.9 9.1e-07 28.8 2.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO31845.1 - 1.5e-05 24.5 1.1 3.1e-05 23.5 0.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO31845.1 - 0.00026 20.7 3.5 0.00064 19.5 2.4 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.1 KOO31845.1 - 0.0045 16.6 0.6 0.0094 15.6 0.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.1 KOO31845.1 - 0.025 14.2 2.8 0.052 13.2 2.0 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO31845.1 - 0.033 13.9 3.1 0.066 12.9 2.1 1.5 1 0 0 1 1 1 0 zinc-RING finger domain DUF3638 PF12340.3 KOO31848.1 - 2.3e-28 98.7 0.4 4.5e-28 97.7 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.3 KOO31848.1 - 7.9e-16 56.8 0.1 2e-15 55.6 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) AAA PF00004.24 KOO31848.1 - 0.031 14.4 0.4 2.8 8.1 0.0 3.7 3 1 1 4 4 4 0 ATPase family associated with various cellular activities (AAA) zf-RING_2 PF13639.1 KOO31848.1 - 0.057 13.2 0.0 0.16 11.8 0.0 1.8 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.1 KOO31848.1 - 0.063 13.0 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 RING-type zinc-finger Amino_oxidase PF01593.19 KOO31849.1 - 3.9e-32 111.8 0.0 6e-32 111.2 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase PHD PF00628.24 KOO31849.1 - 1.6e-06 27.6 11.8 3.3e-06 26.7 8.2 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.1 KOO31849.1 - 0.6 9.4 6.5 1.3 8.4 4.5 1.5 1 0 0 1 1 1 0 PHD-finger LRR_6 PF13516.1 KOO31850.1 - 4e-30 100.4 1.9 0.00087 19.1 0.0 7.2 7 0 0 7 7 7 6 Leucine Rich repeat LRR_4 PF12799.2 KOO31850.1 - 8.8e-06 25.2 0.7 0.33 10.6 0.0 4.3 1 1 5 6 6 6 3 Leucine Rich repeats (2 copies) SpoU_sub_bind PF08032.7 KOO31850.1 - 0.019 15.1 1.7 1.7 8.8 0.1 3.5 1 1 1 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding LRR_1 PF00560.28 KOO31850.1 - 0.026 14.4 0.0 65 4.1 0.0 5.3 7 0 0 7 7 7 0 Leucine Rich Repeat LRR_7 PF13504.1 KOO31850.1 - 0.046 13.9 3.7 47 4.8 0.0 5.8 7 0 0 7 7 7 0 Leucine rich repeat CbiG_N PF11760.3 KOO31850.1 - 0.59 9.8 11.9 17 5.2 0.1 4.7 1 1 4 5 5 5 0 Cobalamin synthesis G N-terminal zf-C2H2_4 PF13894.1 KOO31851.1 - 0.055 13.8 0.2 0.14 12.6 0.2 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.21 KOO31851.1 - 0.27 11.6 1.1 0.58 10.6 0.7 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type Pkinase PF00069.20 KOO31852.1 - 1.5e-20 73.4 0.0 3e-20 72.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Choline_kinase PF01633.15 KOO31852.1 - 0.037 13.5 0.0 0.053 13.0 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase CENP-B_dimeris PF09026.5 KOO31852.1 - 0.059 13.6 1.1 0.095 12.9 0.8 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Kdo PF06293.9 KOO31852.1 - 0.12 11.3 0.0 0.22 10.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Glyco_hydro_20 PF00728.17 KOO31853.1 - 1.4e-49 169.1 0.0 2.5e-48 165.0 0.0 2.7 2 1 0 2 2 2 1 Glycosyl hydrolase family 20, catalytic domain Ricin_B_lectin PF00652.17 KOO31853.1 - 4.5e-09 36.3 0.3 7.6e-05 22.7 0.0 2.3 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain FKBP_C PF00254.23 KOO31855.1 - 5.3e-28 96.8 0.0 9.1e-28 96.1 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase WWE PF02825.15 KOO31857.1 - 0.0095 15.3 1.1 0.051 12.9 0.7 2.0 1 1 0 1 1 1 1 WWE domain FCH PF00611.18 KOO31859.1 - 0.0001 22.4 0.3 0.0001 22.4 0.2 2.1 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain RCC1_2 PF13540.1 KOO31860.1 - 2.1e-28 97.2 54.5 2.2e-05 23.9 0.9 7.7 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.13 KOO31860.1 - 2.7e-26 91.5 33.5 9.1e-06 25.7 0.2 7.2 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat EF-hand_1 PF00036.27 KOO31860.1 - 1e-09 36.9 2.3 0.00023 20.2 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO31860.1 - 2.2e-08 34.0 0.2 5e-08 32.9 0.2 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO31860.1 - 1.6e-06 27.5 0.2 0.0009 18.9 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO31860.1 - 4.2e-05 23.0 7.4 6.5e-05 22.4 0.3 3.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO31860.1 - 0.041 13.2 0.1 0.041 13.2 0.1 2.6 3 0 0 3 3 3 0 EF hand SPARC_Ca_bdg PF10591.4 KOO31860.1 - 0.094 12.7 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO31860.1 - 0.24 11.1 0.1 0.57 9.9 0.0 1.5 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand HECT PF00632.20 KOO31862.1 - 9.3e-29 100.5 0.0 2.4e-28 99.1 0.0 1.7 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) PUB PF09409.5 KOO31862.1 - 1.7e-12 46.9 0.0 3.9e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 PUB domain Spc7 PF08317.6 KOO31863.1 - 1.9 7.0 8.4 3.5 6.1 5.8 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein APG6 PF04111.7 KOO31863.1 - 6.5 5.6 11.4 11 4.9 7.9 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 WD40 PF00400.27 KOO31865.1 - 3.7e-22 77.3 15.6 0.00041 20.1 0.1 8.2 8 0 0 8 8 8 7 WD domain, G-beta repeat DUF1501 PF07394.7 KOO31866.1 - 1.7e-39 135.8 0.1 3.3e-39 134.8 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1501) DUF1800 PF08811.6 KOO31866.1 - 3e-26 92.3 0.0 4.9e-26 91.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1800) NAD_binding_10 PF13460.1 KOO31868.1 - 3.6e-16 59.7 0.2 2.7e-15 56.8 0.2 2.1 1 1 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 KOO31868.1 - 0.00026 20.2 0.0 0.00084 18.6 0.1 1.8 2 0 0 2 2 2 1 NmrA-like family Epimerase PF01370.16 KOO31868.1 - 0.0029 17.0 0.0 1 8.7 0.0 2.3 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family TrkA_N PF02254.13 KOO31868.1 - 0.013 15.5 0.0 0.027 14.4 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain adh_short PF00106.20 KOO31868.1 - 0.031 14.1 0.4 0.088 12.7 0.2 1.8 2 0 0 2 2 2 0 short chain dehydrogenase Ldh_1_N PF00056.18 KOO31868.1 - 0.061 13.1 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.19 KOO31868.1 - 0.072 13.3 0.1 0.23 11.7 0.0 1.9 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 KOO31868.1 - 0.12 11.3 0.1 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase Pkinase PF00069.20 KOO31869.1 - 5.1e-51 173.3 0.0 6.3e-51 173.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO31869.1 - 2.2e-19 69.5 0.0 3.1e-19 69.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Plectin PF00681.15 KOO31869.1 - 0.071 12.6 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 Plectin repeat Pectate_lyase_3 PF12708.2 KOO31874.1 - 0.0024 18.0 0.1 0.0028 17.8 0.1 1.1 1 0 0 1 1 1 1 Pectate lyase superfamily protein DUF3494 PF11999.3 KOO31874.1 - 0.016 14.8 0.2 0.027 14.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3494) EF-hand_1 PF00036.27 KOO31875.1 - 4e-12 44.5 1.4 1.7e-05 23.7 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO31875.1 - 3e-09 36.8 0.2 5.4e-09 36.0 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO31875.1 - 4e-08 32.4 0.2 0.00024 20.7 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO31875.1 - 1.4e-07 31.0 3.2 6.8e-06 25.6 0.3 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO31875.1 - 3.7e-05 22.8 0.6 0.0034 16.6 0.0 2.4 2 0 0 2 2 2 1 EF hand SPARC_Ca_bdg PF10591.4 KOO31875.1 - 0.018 15.0 0.0 0.032 14.2 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region DUF4199 PF13858.1 KOO31875.1 - 0.06 13.2 0.3 0.15 12.0 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4199) PTS_2-RNA PF01885.11 KOO31875.1 - 0.082 12.2 0.0 5.3 6.3 0.0 2.3 2 0 0 2 2 2 0 RNA 2'-phosphotransferase, Tpt1 / KptA family EF-hand_4 PF12763.2 KOO31875.1 - 0.12 12.1 0.1 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand ketoacyl-synt PF00109.21 KOO31876.1 - 1e-44 152.9 7.7 2.4e-44 151.7 5.3 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 KOO31876.1 - 3.7e-28 97.7 3.6 8.5e-28 96.5 2.5 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.20 KOO31876.1 - 1.3e-06 28.6 0.0 2.4e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site DNA_gyraseB_C PF00986.16 KOO31876.1 - 0.15 11.7 0.0 0.34 10.6 0.0 1.5 1 0 0 1 1 1 0 DNA gyrase B subunit, carboxyl terminus PDZ PF00595.19 KOO31878.1 - 0.006 16.7 0.1 0.01 16.0 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) EF-hand_1 PF00036.27 KOO31879.1 - 0.0039 16.3 0.0 0.008 15.4 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO31879.1 - 0.0057 16.4 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.1 KOO31879.1 - 0.0063 15.8 0.0 0.013 14.8 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO31879.1 - 0.018 15.1 0.0 0.025 14.7 0.0 1.4 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_8 PF13833.1 KOO31879.1 - 0.036 13.6 0.0 0.059 13.0 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair Gly-zipper_OmpA PF13436.1 KOO31879.1 - 0.11 12.1 1.9 0.2 11.3 1.0 1.6 2 0 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain Gly-zipper_YMGG PF13441.1 KOO31879.1 - 0.17 11.3 8.0 0.31 10.5 5.6 1.4 1 0 0 1 1 1 0 YMGG-like Gly-zipper Gly-zipper_Omp PF13488.1 KOO31879.1 - 0.5 10.0 7.9 0.85 9.3 5.5 1.4 1 0 0 1 1 1 0 Glycine zipper Bacteriocin_IIc PF10439.4 KOO31879.1 - 0.65 10.1 3.6 1 9.5 2.5 1.3 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Xpo1 PF08389.7 KOO31880.1 - 0.002 18.0 0.3 0.054 13.3 0.0 3.1 3 0 0 3 3 3 1 Exportin 1-like protein Reo_sigmaC PF04582.7 KOO31880.1 - 0.093 11.8 0.8 0.16 11.1 0.6 1.3 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Atg14 PF10186.4 KOO31880.1 - 0.16 10.9 6.7 0.32 9.9 4.7 1.5 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Spc7 PF08317.6 KOO31880.1 - 2 6.9 7.6 3.1 6.3 5.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Guanylate_cyc PF00211.15 KOO31881.1 - 5.4e-07 29.1 0.0 9.6e-07 28.3 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Peptidase_M24 PF00557.19 KOO31882.1 - 3.5e-45 154.1 0.1 5.2e-45 153.5 0.1 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 SnoaL_2 PF12680.2 KOO31882.1 - 9.1e-06 26.0 0.1 6.9e-05 23.1 0.0 2.5 2 0 0 2 2 2 1 SnoaL-like domain HD_4 PF13328.1 KOO31885.1 - 5.5e-36 123.5 0.3 9.3e-36 122.8 0.2 1.4 1 0 0 1 1 1 1 HD domain RelA_SpoT PF04607.12 KOO31885.1 - 5.6e-30 103.7 0.0 6.2e-29 100.3 0.0 2.7 3 1 0 3 3 3 1 Region found in RelA / SpoT proteins ACT_4 PF13291.1 KOO31885.1 - 6.2e-17 61.7 0.2 1.1e-16 60.9 0.1 1.4 1 0 0 1 1 1 1 ACT domain HD PF01966.17 KOO31885.1 - 3.5e-05 23.8 0.0 7.6e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 HD domain TGS PF02824.16 KOO31885.1 - 0.0014 18.3 0.0 0.004 16.9 0.0 1.8 1 0 0 1 1 1 1 TGS domain ACT PF01842.20 KOO31885.1 - 0.0016 17.8 0.1 0.0033 16.8 0.0 1.6 1 0 0 1 1 1 1 ACT domain Gp-FAR-1 PF05823.7 KOO31885.1 - 0.036 14.0 0.0 4.7 7.1 0.0 2.4 2 0 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) CN_hydrolase PF00795.17 KOO31887.1 - 5.7e-05 22.5 0.0 0.00012 21.4 0.0 1.5 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase FAD_binding_7 PF03441.9 KOO31888.1 - 1.5e-43 148.9 0.9 2e-43 148.5 0.6 1.1 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase Glyco_transf_90 PF05686.7 KOO31890.1 - 6.6e-14 51.3 0.0 1.9e-11 43.2 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.1 KOO31890.1 - 0.0066 16.6 0.0 0.019 15.1 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 MscS_porin PF12795.2 KOO31891.1 - 0.0062 15.8 2.2 0.0087 15.3 1.5 1.2 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain ASCH PF04266.9 KOO31891.1 - 0.064 13.6 0.0 0.16 12.3 0.0 1.7 2 0 0 2 2 2 0 ASCH domain RhoGAP PF00620.22 KOO31893.1 - 7.2e-15 54.9 0.0 1.8e-14 53.5 0.0 1.7 2 0 0 2 2 2 1 RhoGAP domain PDZ PF00595.19 KOO31893.1 - 0.0023 18.0 0.0 0.0037 17.4 0.0 1.3 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) FGGY_C PF02782.11 KOO31894.1 - 0.03 13.9 1.3 0.036 13.6 0.9 1.0 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain NUDIX PF00293.23 KOO31896.1 - 0.0019 17.8 0.0 0.0034 17.0 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain Bestrophin PF01062.16 KOO31897.1 - 2.3e-25 89.1 0.1 2.9e-25 88.8 0.0 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel SAM_1 PF00536.25 KOO31898.1 - 3.2e-11 43.2 0.0 2.9e-05 24.1 0.0 2.2 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 KOO31898.1 - 9.2e-08 31.8 0.0 6.9e-05 22.6 0.0 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) HTH_24 PF13412.1 KOO31898.1 - 0.092 12.1 0.1 0.17 11.3 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding GFA PF04828.9 KOO31899.1 - 3.3e-12 46.1 3.7 5.4e-12 45.5 0.4 2.1 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme S4_2 PF13275.1 KOO31900.1 - 0.0023 17.4 0.0 0.0037 16.8 0.0 1.3 1 0 0 1 1 1 1 S4 domain DUF4116 PF13475.1 KOO31905.1 - 3.9e-55 183.1 0.0 5.4e-15 54.6 0.0 5.3 2 2 2 5 5 5 4 Domain of unknown function (DUF4116) EF-hand_1 PF00036.27 KOO31905.1 - 4.6e-16 56.8 0.6 3.1e-07 29.2 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 KOO31905.1 - 9e-13 48.1 0.0 2.3e-12 46.8 0.0 1.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO31905.1 - 1.8e-12 46.6 1.4 1.6e-11 43.6 0.1 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO31905.1 - 1.8e-11 42.8 0.1 1.5e-05 24.4 0.0 2.8 3 0 0 3 3 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO31905.1 - 3.6e-09 35.5 3.8 9.3e-05 21.6 0.0 3.3 3 1 0 3 3 3 2 EF hand EF-hand_9 PF14658.1 KOO31905.1 - 0.00015 21.5 0.0 0.00027 20.7 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain DUF1667 PF07892.6 KOO31905.1 - 0.0045 16.6 0.0 27 4.5 0.0 3.9 2 1 3 5 5 5 0 Protein of unknown function (DUF1667) EF-hand_4 PF12763.2 KOO31905.1 - 0.0067 16.1 0.0 0.014 15.0 0.0 1.5 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand Rsbr_N PF08678.5 KOO31905.1 - 0.026 14.3 0.0 23 4.8 0.0 3.6 1 1 3 4 4 4 0 Rsbr N terminal SPARC_Ca_bdg PF10591.4 KOO31905.1 - 0.17 11.9 0.0 0.41 10.6 0.0 1.6 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Fringe PF02434.11 KOO31908.1 - 1.4e-07 31.0 0.0 1.8e-05 24.0 0.0 2.2 1 1 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.16 KOO31908.1 - 8.9e-05 22.1 0.0 0.00016 21.3 0.0 1.3 1 0 0 1 1 1 1 Galactosyltransferase MOZ_SAS PF01853.13 KOO31909.1 - 1.5e-77 259.1 0.1 2.1e-77 258.6 0.1 1.2 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.3 KOO31909.1 - 3.9e-17 61.6 1.3 9e-17 60.5 0.5 2.0 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Chromo PF00385.19 KOO31909.1 - 0.052 13.2 3.6 0.31 10.7 0.5 2.6 1 1 1 2 2 2 0 Chromo (CHRromatin Organisation MOdifier) domain TrpBP PF02081.10 KOO31909.1 - 0.075 12.4 0.3 0.16 11.3 0.2 1.5 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein NESP55 PF06390.7 KOO31910.1 - 0.25 10.6 0.9 0.35 10.2 0.6 1.1 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Ion_trans PF00520.26 KOO31911.1 - 5.1e-15 55.2 2.6 6.8e-15 54.8 1.8 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.7 KOO31911.1 - 0.00098 17.6 1.0 0.0013 17.2 0.7 1.2 1 0 0 1 1 1 1 Polycystin cation channel PARP PF00644.15 KOO31912.1 - 1.1e-52 178.5 0.0 3.6e-29 101.6 0.0 3.7 4 0 0 4 4 4 3 Poly(ADP-ribose) polymerase catalytic domain AAA_12 PF13087.1 KOO31912.1 - 2.1e-29 102.3 0.0 3.1e-28 98.5 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.1 KOO31912.1 - 1.4e-22 80.3 0.1 1.4e-21 77.1 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KOO31912.1 - 5.2e-09 35.7 0.1 4.3e-07 29.5 0.0 3.0 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 KOO31912.1 - 4.3e-06 26.4 0.0 0.00055 19.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain zf-CCCH PF00642.19 KOO31912.1 - 9.4e-06 25.1 1.6 1.9e-05 24.2 1.1 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Viral_helicase1 PF01443.13 KOO31912.1 - 0.0019 17.7 0.0 3.8 6.9 0.0 3.4 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.1 KOO31912.1 - 0.052 13.6 0.0 0.2 11.7 0.0 2.0 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 KOO31912.1 - 0.1 11.8 0.0 0.21 10.7 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein DUF2075 PF09848.4 KOO31912.1 - 0.14 11.0 0.0 0.3 10.0 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Tox-ART-HYD1 PF15633.1 KOO31912.1 - 0.2 12.4 0.0 0.61 10.9 0.0 1.9 1 0 0 1 1 1 0 HYD1 signature containing ADP-ribosyltransferase FUSC-like PF12805.2 KOO31912.1 - 0.36 9.7 1.6 0.93 8.3 1.1 1.7 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS PARP PF00644.15 KOO31913.1 - 6.1e-38 130.3 0.0 2.9e-24 85.6 0.0 2.4 2 1 0 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain Ras PF00071.17 KOO31914.1 - 1.1e-48 164.6 0.0 1.3e-48 164.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Arf PF00025.16 KOO31914.1 - 2.4e-16 59.4 0.0 2.7e-16 59.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 KOO31914.1 - 5.8e-16 59.0 0.0 8.6e-16 58.5 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Gtr1_RagA PF04670.7 KOO31914.1 - 6.1e-05 22.2 0.0 7.8e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KOO31914.1 - 0.00017 21.1 0.0 0.00045 19.7 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 KOO31914.1 - 0.00034 20.7 0.3 0.038 14.1 0.0 2.8 2 1 0 2 2 2 1 AAA domain ArgK PF03308.11 KOO31914.1 - 0.0021 16.8 0.4 0.092 11.5 0.1 2.2 2 0 0 2 2 2 1 ArgK protein AAA_33 PF13671.1 KOO31914.1 - 0.0099 15.7 0.0 0.018 14.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 KOO31914.1 - 0.016 15.4 0.0 0.11 12.6 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KOO31914.1 - 0.025 14.2 0.0 0.093 12.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) cobW PF02492.14 KOO31914.1 - 0.064 12.6 0.4 0.69 9.3 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.1 KOO31914.1 - 0.072 12.4 0.1 0.5 9.7 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 KOO31914.1 - 0.11 12.4 0.4 2.3 8.1 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain PduV-EutP PF10662.4 KOO31914.1 - 0.11 11.9 0.0 6.1 6.3 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.18 KOO31914.1 - 0.14 12.1 0.0 0.2 11.6 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_24 PF13479.1 KOO31914.1 - 0.14 11.7 0.1 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.13 KOO31914.1 - 0.14 11.3 0.1 8.4 5.6 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B SH3_2 PF07653.12 KOO31915.1 - 8e-12 44.4 0.0 1.5e-11 43.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.1 KOO31915.1 - 7.3e-11 41.4 0.1 1.5e-10 40.4 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 KOO31915.1 - 1.1e-08 34.3 0.2 2.3e-08 33.2 0.2 1.6 1 0 0 1 1 1 1 SH3 domain WW PF00397.21 KOO31916.1 - 1.6e-16 59.8 0.3 7.7e-07 28.8 0.0 2.6 2 0 0 2 2 2 2 WW domain NPCBM_assoc PF10633.4 KOO31916.1 - 0.0059 16.6 0.2 2.3 8.3 0.0 2.9 3 0 0 3 3 3 2 NPCBM-associated, NEW3 domain of alpha-galactosidase NUC173 PF08161.7 KOO31917.1 - 2.8e-30 105.1 0.0 6.1e-28 97.5 0.0 2.4 2 0 0 2 2 2 2 NUC173 domain Mg_trans_NIPA PF05653.9 KOO31918.1 - 0.0003 19.8 2.6 0.0054 15.7 0.1 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA CitMHS PF03600.11 KOO31918.1 - 0.0049 15.4 0.0 0.0081 14.7 0.0 1.4 1 1 0 1 1 1 1 Citrate transporter EamA PF00892.15 KOO31918.1 - 0.054 13.5 1.3 0.054 13.5 0.9 3.0 3 1 0 3 3 3 0 EamA-like transporter family MORN PF02493.15 KOO31919.1 - 6.6e-31 104.1 22.7 6.1e-08 31.9 1.3 6.4 6 0 0 6 6 6 5 MORN repeat TFIIIC_sub6 PF10419.4 KOO31919.1 - 2.4 7.6 5.5 23 4.5 0.1 3.6 3 0 0 3 3 3 0 TFIIIC subunit ART PF01129.13 KOO31920.1 - 5.7e-18 64.8 0.0 8.4e-18 64.2 0.0 1.2 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Ank_5 PF13857.1 KOO31920.1 - 6.6e-09 35.7 1.0 1.5e-08 34.6 0.1 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO31920.1 - 1.5e-05 24.7 0.0 0.023 14.8 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat ADPrib_exo_Tox PF03496.9 KOO31920.1 - 2.8e-05 23.4 0.0 5.3e-05 22.5 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Ank_4 PF13637.1 KOO31920.1 - 9.6e-05 22.7 0.0 0.00021 21.7 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO31920.1 - 0.00019 21.6 0.5 0.00097 19.4 0.0 2.3 2 1 1 3 3 3 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO31920.1 - 0.00042 19.9 0.0 0.15 11.9 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat OmdA PF13376.1 KOO31920.1 - 0.92 9.2 3.1 6.3 6.5 0.1 3.0 3 0 0 3 3 3 0 Bacteriocin-protection, YdeI or OmpD-Associated DNase_II PF03265.10 KOO31921.1 - 1.7e-53 181.7 0.0 2.2e-53 181.3 0.0 1.1 1 0 0 1 1 1 1 Deoxyribonuclease II DHC_N2 PF08393.8 KOO31922.1 - 3.6e-122 407.8 0.2 3.6e-122 407.8 0.1 2.1 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 KOO31922.1 - 1.9e-99 331.8 0.0 5.3e-99 330.4 0.0 1.8 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_7 PF12775.2 KOO31922.1 - 5.3e-46 156.9 0.0 1e-45 155.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_5 PF07728.9 KOO31922.1 - 9.1e-20 70.8 0.0 4.1e-05 23.3 0.0 4.6 3 1 0 3 3 3 3 AAA domain (dynein-related subfamily) RNA_helicase PF00910.17 KOO31922.1 - 1.6e-06 28.2 0.2 0.057 13.5 0.0 4.2 4 0 0 4 4 4 2 RNA helicase AAA_16 PF13191.1 KOO31922.1 - 5.6e-06 26.4 0.1 0.011 15.7 0.0 3.4 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 KOO31922.1 - 9e-06 25.8 0.2 0.022 14.8 0.0 3.9 4 0 0 4 4 3 1 AAA domain AAA PF00004.24 KOO31922.1 - 9.9e-06 25.7 0.5 0.43 10.7 0.0 3.7 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 KOO31922.1 - 0.0001 21.9 4.8 0.021 14.5 0.0 4.3 4 0 0 4 4 4 1 NACHT domain AAA_25 PF13481.1 KOO31922.1 - 0.00053 19.4 1.8 1.3 8.3 0.0 3.6 3 0 0 3 3 3 1 AAA domain UPF0079 PF02367.12 KOO31922.1 - 0.00065 19.3 1.4 0.11 12.1 0.0 3.2 3 0 0 3 3 3 1 Uncharacterised P-loop hydrolase UPF0079 AAA_19 PF13245.1 KOO31922.1 - 0.0011 18.6 1.8 0.34 10.7 0.2 3.0 3 0 0 3 3 3 1 Part of AAA domain T2SE PF00437.15 KOO31922.1 - 0.0013 17.6 1.3 0.054 12.3 0.0 2.9 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_30 PF13604.1 KOO31922.1 - 0.0048 16.4 0.4 1.9 8.0 0.1 3.1 3 0 0 3 3 3 1 AAA domain Sigma54_activat PF00158.21 KOO31922.1 - 0.009 15.4 0.1 0.079 12.4 0.0 2.5 3 0 0 3 3 3 1 Sigma-54 interaction domain Mg_chelatase PF01078.16 KOO31922.1 - 0.018 14.1 2.7 0.34 10.0 0.0 3.0 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_17 PF13207.1 KOO31922.1 - 0.02 15.7 0.0 0.24 12.2 0.0 3.0 3 0 0 3 3 1 0 AAA domain AAA_33 PF13671.1 KOO31922.1 - 0.02 14.7 0.9 5.7 6.8 0.0 3.8 3 0 0 3 3 3 0 AAA domain RE_SinI PF09570.5 KOO31922.1 - 0.028 13.4 0.0 0.073 12.0 0.0 1.6 1 0 0 1 1 1 0 SinI restriction endonuclease DUF853 PF05872.7 KOO31922.1 - 0.038 12.3 2.9 1.4 7.1 0.1 2.9 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF853) AAA_18 PF13238.1 KOO31922.1 - 0.047 13.9 0.0 2.2 8.5 0.0 3.5 4 0 0 4 4 4 0 AAA domain MobB PF03205.9 KOO31922.1 - 0.069 12.8 0.5 12 5.6 0.0 3.4 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.22 KOO31922.1 - 0.13 12.5 0.2 1 9.6 0.0 2.6 3 0 0 3 3 2 0 ABC transporter FtsK_SpoIIIE PF01580.13 KOO31922.1 - 0.32 10.4 2.5 0.75 9.2 0.0 2.6 3 0 0 3 3 3 0 FtsK/SpoIIIE family OGFr_N PF04664.8 KOO31923.1 - 3.9e-50 170.1 0.0 4.7e-50 169.8 0.0 1.0 1 0 0 1 1 1 1 Opioid growth factor receptor (OGFr) conserved region Inhibitor_I9 PF05922.11 KOO31923.1 - 0.036 14.6 0.0 0.068 13.7 0.0 1.5 1 0 0 1 1 1 0 Peptidase inhibitor I9 RRM_1 PF00076.17 KOO31924.1 - 2.6e-20 71.8 0.0 4.1e-20 71.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO31924.1 - 1.4e-10 40.9 0.0 2.7e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO31924.1 - 0.0002 21.1 0.0 0.0004 20.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PepSY_2 PF13670.1 KOO31924.1 - 0.042 13.7 0.2 0.11 12.3 0.2 1.7 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain ACC_epsilon PF13822.1 KOO31924.1 - 0.16 12.3 7.6 0.65 10.4 0.6 2.7 2 0 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit Period_C PF12114.3 KOO31924.1 - 2.6 7.6 6.0 4.3 6.8 4.2 1.2 1 0 0 1 1 1 0 Period protein 2/3C-terminal region Choline_transpo PF04515.7 KOO31925.1 - 1.1e-54 185.5 31.4 1.1e-54 185.5 21.7 2.7 3 0 0 3 3 3 1 Plasma-membrane choline transporter Epimerase PF01370.16 KOO31927.1 - 6.1e-17 61.8 0.0 7.2e-17 61.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 KOO31927.1 - 3.5e-07 29.3 0.1 3.5e-07 29.3 0.0 1.5 2 0 0 2 2 2 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 KOO31927.1 - 0.00041 19.3 1.3 0.0032 16.4 0.0 2.0 1 1 1 2 2 2 2 Polysaccharide biosynthesis protein Epimerase PF01370.16 KOO31928.1 - 2.3e-22 79.5 0.0 3.2e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Filamin PF00630.14 KOO31929.1 - 2.9e-13 50.2 0.0 8e-07 29.5 0.0 4.4 5 0 0 5 5 5 4 Filamin/ABP280 repeat MerR-DNA-bind PF09278.6 KOO31930.1 - 4.1e-16 59.1 11.4 0.8 10.1 0.1 11.5 8 2 4 12 12 12 5 MerR, DNA binding N_methyl_2 PF13544.1 KOO31930.1 - 1.2e-09 37.1 16.9 5 6.7 0.1 10.2 6 3 4 10 10 10 4 Type IV pilin N-term methylation site GFxxxE Pentapeptide_4 PF13599.1 KOO31930.1 - 8.7e-08 31.8 0.0 0.00024 20.8 0.0 3.8 3 2 1 4 4 4 2 Pentapeptide repeats (9 copies) Ribosomal_L13e PF01294.13 KOO31930.1 - 4.9e-06 26.1 11.7 0.6 9.5 0.0 7.5 2 2 7 9 9 9 3 Ribosomal protein L13e HTH_20 PF12840.2 KOO31930.1 - 5e-05 23.0 1.7 0.65 9.8 0.3 5.1 2 2 0 2 2 2 1 Helix-turn-helix domain N_methyl PF07963.7 KOO31930.1 - 0.00027 20.4 21.4 3.7 7.4 0.0 9.2 9 0 0 9 9 9 1 Prokaryotic N-terminal methylation motif HTH_27 PF13463.1 KOO31930.1 - 0.0026 18.0 0.1 40 4.6 0.0 5.4 3 2 3 6 6 6 0 Winged helix DNA-binding domain HTH_38 PF13936.1 KOO31930.1 - 0.0036 16.8 1.2 23 4.6 0.0 5.1 4 1 1 5 5 5 0 Helix-turn-helix domain DUF2812 PF11193.3 KOO31930.1 - 0.0077 16.3 6.6 3 8.0 0.0 6.3 3 2 4 8 8 8 1 Protein of unknown function (DUF2812) RPAP1_C PF08620.5 KOO31930.1 - 0.015 15.1 17.7 20 5.1 0.1 10.1 7 3 5 12 12 12 0 RPAP1-like, C-terminal RraB PF06877.6 KOO31930.1 - 0.024 15.2 0.1 25 5.5 0.0 4.0 2 2 2 4 4 4 0 Regulator of ribonuclease activity B LytR_C PF13399.1 KOO31930.1 - 1.3 9.4 4.5 46 4.4 0.0 4.7 2 2 3 5 5 5 0 LytR cell envelope-related transcriptional attenuator DUF3726 PF12525.3 KOO31930.1 - 4.1 7.2 20.9 8.3 6.2 0.6 5.3 2 2 4 6 6 6 0 Protein of unknown function (DUF3726) UQ_con PF00179.21 KOO31932.1 - 7.2e-21 74.0 0.0 1.8e-20 72.8 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Ufd2P_core PF10408.4 KOO31932.1 - 0.0025 16.1 0.0 0.0031 15.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core UEV PF05743.8 KOO31932.1 - 0.0058 16.2 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 UEV domain HAD_2 PF13419.1 KOO31932.1 - 0.076 13.2 0.1 0.18 12.0 0.0 1.6 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase FYVE_2 PF02318.11 KOO31932.1 - 0.57 10.1 0.0 0.57 10.1 0.0 2.4 2 1 0 2 2 2 0 FYVE-type zinc finger CRAL_TRIO PF00650.15 KOO31933.1 - 3.4e-15 55.8 0.0 5.2e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain Peptidase_S49 PF01343.13 KOO31934.1 - 3.2e-60 202.3 0.1 2.1e-39 134.7 0.0 2.4 2 0 0 2 2 2 2 Peptidase family S49 SDH_sah PF01972.11 KOO31934.1 - 4.8e-05 22.2 0.1 9e-05 21.3 0.0 1.3 1 0 0 1 1 1 1 Serine dehydrogenase proteinase OKR_DC_1_N PF03709.10 KOO31934.1 - 0.0069 16.4 0.0 0.36 10.9 0.0 2.5 2 0 0 2 2 2 1 Orn/Lys/Arg decarboxylase, N-terminal domain Peptidase_C23 PF05379.6 KOO31934.1 - 0.2 11.6 0.0 12 5.9 0.0 2.7 3 0 0 3 3 3 0 Carlavirus endopeptidase MRP-L28 PF09812.4 KOO31935.1 - 0.009 15.8 0.1 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 Ribosomal_L14 PF00238.14 KOO31936.1 - 8.8e-30 102.9 0.1 1.5e-29 102.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Osmo_CC PF08946.5 KOO31937.1 - 0.11 12.4 0.3 0.83 9.7 0.0 2.6 3 0 0 3 3 3 0 Osmosensory transporter coiled coil PP2C PF00481.16 KOO31938.1 - 4.8e-29 101.5 0.0 6.2e-29 101.1 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOO31938.1 - 9.7e-08 31.9 0.1 0.0015 18.2 0.1 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 KOO31938.1 - 0.00011 21.7 0.0 0.00019 20.9 0.0 1.3 1 1 0 1 1 1 1 Protein phosphatase 2C DNA_pol_B_palm PF14792.1 KOO31939.1 - 1.8e-21 76.2 0.0 6.9e-20 71.1 0.0 2.3 2 0 0 2 2 2 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.1 KOO31939.1 - 2.8e-20 71.7 0.0 6.5e-20 70.6 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta thumb HHH_8 PF14716.1 KOO31939.1 - 2.8e-17 62.6 1.9 1.9e-16 59.9 0.4 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.4 KOO31939.1 - 7.7e-08 31.7 0.2 1.8e-07 30.5 0.0 1.8 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda WWE PF02825.15 KOO31939.1 - 1.1e-06 27.9 0.0 2.4e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 WWE domain HHH PF00633.18 KOO31939.1 - 0.0019 17.7 1.4 1.8 8.4 0.3 2.7 2 0 0 2 2 2 2 Helix-hairpin-helix motif HHH_5 PF14520.1 KOO31939.1 - 0.0022 18.1 4.2 0.019 15.1 1.5 2.7 1 1 2 3 3 3 3 Helix-hairpin-helix domain Cdd1 PF11731.3 KOO31939.1 - 0.065 13.1 0.2 1.4 8.9 0.1 2.4 1 1 0 1 1 1 0 Pathogenicity locus HHH_3 PF12836.2 KOO31939.1 - 0.086 12.7 0.2 1.1 9.2 0.0 2.2 2 0 0 2 2 2 0 Helix-hairpin-helix motif IMS_HHH PF11798.3 KOO31939.1 - 0.31 11.1 1.2 9.8 6.4 0.1 2.5 2 0 0 2 2 2 0 IMS family HHH motif EF-hand_1 PF00036.27 KOO31940.1 - 3.7e-44 144.6 12.3 3.8e-06 25.8 0.0 8.5 8 0 0 8 8 8 8 EF hand EF-hand_6 PF13405.1 KOO31940.1 - 3e-43 141.7 8.8 3.4e-05 23.3 0.1 9.0 9 0 0 9 9 9 8 EF-hand domain EF-hand_7 PF13499.1 KOO31940.1 - 7.2e-42 141.3 11.3 5.8e-12 45.5 0.0 4.6 4 1 1 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.1 KOO31940.1 - 1.5e-32 109.4 19.2 4.1e-06 25.8 0.1 8.8 9 0 0 9 9 9 7 EF hand EF-hand_8 PF13833.1 KOO31940.1 - 1.9e-24 85.0 18.0 9.1e-06 25.1 0.1 8.1 5 3 3 8 8 8 7 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO31940.1 - 1.1e-08 35.0 0.5 0.73 9.8 0.0 4.6 4 1 0 4 4 4 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO31940.1 - 0.00018 21.0 4.2 0.62 9.7 0.0 5.6 6 1 1 7 7 7 1 EF hand EF-hand_9 PF14658.1 KOO31940.1 - 0.00067 19.5 0.0 5.6 6.9 0.0 5.3 5 1 1 6 6 6 1 EF-hand domain EF-hand_4 PF12763.2 KOO31940.1 - 0.11 12.1 4.8 16 5.3 0.0 4.7 3 2 3 6 6 6 0 Cytoskeletal-regulatory complex EF hand SNARE PF05739.14 KOO31941.1 - 2.1e-10 40.1 5.2 2.1e-10 40.1 3.6 2.7 3 0 0 3 3 3 1 SNARE domain Tropomyosin_1 PF12718.2 KOO31941.1 - 0.00068 19.5 8.1 0.00068 19.5 5.6 2.8 2 1 1 3 3 3 1 Tropomyosin like Baculo_PEP_C PF04513.7 KOO31941.1 - 0.049 13.4 3.0 0.2 11.4 0.3 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Prominin PF05478.6 KOO31941.1 - 0.49 7.8 7.3 0.089 10.3 0.6 2.0 2 0 0 2 2 2 0 Prominin DDE_Tnp_1_6 PF13751.1 KOO31941.1 - 0.5 10.3 5.9 0.13 12.2 1.6 1.9 2 0 0 2 2 2 0 Transposase DDE domain NPV_P10 PF05531.7 KOO31941.1 - 1.7 8.9 10.5 4.5 7.5 3.1 3.3 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein APG17 PF04108.7 KOO31941.1 - 3.4 6.3 11.7 3.2 6.4 3.3 2.0 1 1 1 2 2 2 0 Autophagy protein Apg17 Cluap1 PF10234.4 KOO31941.1 - 5.3 6.1 20.0 0.32 10.1 3.9 2.2 2 0 0 2 2 2 0 Clusterin-associated protein-1 Rhodanese PF00581.15 KOO31942.1 - 2.3e-26 92.3 0.0 1.6e-12 47.8 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain MFS_1 PF07690.11 KOO31943.1 - 0.0019 17.0 8.0 0.0021 16.8 5.6 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Acyl_transf_3 PF01757.17 KOO31943.1 - 0.24 10.1 7.9 0.93 8.2 3.3 1.9 1 1 1 2 2 2 0 Acyltransferase family YoqO PF14037.1 KOO31943.1 - 0.41 10.7 6.4 0.67 10.0 4.4 1.5 1 1 0 1 1 1 0 YoqO-like protein ABC2_membrane_3 PF12698.2 KOO31943.1 - 0.55 9.2 12.9 0.59 9.1 8.9 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein MARVEL PF01284.18 KOO31943.1 - 1.4 8.7 7.1 1.9 8.3 4.9 1.2 1 0 0 1 1 1 0 Membrane-associating domain Tetraspannin PF00335.15 KOO31943.1 - 1.8 7.7 5.3 0.73 9.0 2.2 1.4 2 0 0 2 2 2 0 Tetraspanin family VIT1 PF01988.14 KOO31943.1 - 3.8 6.9 7.4 4.5 6.7 5.2 1.2 1 0 0 1 1 1 0 VIT family Laminin_G_3 PF13385.1 KOO31944.1 - 2.3e-11 44.1 0.0 1.3e-09 38.4 0.0 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily DNA_gyraseB PF00204.20 KOO31944.1 - 0.0033 16.6 0.0 0.93 8.6 0.0 2.0 2 0 0 2 2 2 2 DNA gyrase B DUF4348 PF14254.1 KOO31944.1 - 0.056 12.5 0.0 5.4 6.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4348) Methyltransf_12 PF08242.7 KOO31946.1 - 5.7e-10 39.5 0.0 1.2e-09 38.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO31946.1 - 3.5e-08 33.3 0.0 8.7e-08 32.0 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO31946.1 - 4e-08 33.8 0.1 1.2e-07 32.2 0.1 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO31946.1 - 2.1e-06 28.0 0.2 4.7e-06 26.8 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO31946.1 - 7.1e-05 23.2 0.0 0.00016 22.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO31946.1 - 0.0005 19.6 0.0 0.00088 18.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO31946.1 - 0.0012 18.8 2.3 0.0051 16.8 1.6 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 KOO31946.1 - 0.041 12.9 0.0 0.1 11.6 0.0 1.6 2 0 0 2 2 2 0 Putative methyltransferase tRNA_bind PF01588.15 KOO31947.1 - 1.3e-25 89.0 0.0 1.8e-25 88.5 0.0 1.2 1 0 0 1 1 1 1 Putative tRNA binding domain DUF846 PF05832.7 KOO31948.1 - 5.5e-44 149.3 12.1 7.3e-44 148.9 8.4 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) FA_desaturase PF00487.19 KOO31950.1 - 1.7e-16 60.4 21.0 1.7e-16 60.4 14.5 2.2 1 1 1 2 2 2 2 Fatty acid desaturase GRDA PF04723.9 KOO31951.1 - 0.19 11.4 1.2 0.28 10.8 0.8 1.2 1 0 0 1 1 1 0 Glycine reductase complex selenoprotein A EamA PF00892.15 KOO31952.1 - 5.5e-17 61.9 18.1 1.2e-11 44.6 5.4 2.6 2 0 0 2 2 2 2 EamA-like transporter family 2OG-FeII_Oxy_3 PF13640.1 KOO31953.1 - 1.1e-13 51.5 0.4 4.9e-13 49.4 0.3 2.1 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO31953.1 - 0.0056 16.2 0.0 0.014 14.9 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CmcH_NodU PF02543.10 KOO31954.1 - 1.5e-27 96.6 1.3 1.1e-15 57.6 0.0 4.7 4 1 1 5 5 5 3 Carbamoyltransferase ABC_tran PF00005.22 KOO31954.1 - 3e-07 30.7 0.0 7.2e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 KOO31954.1 - 0.00094 19.2 0.0 0.0014 18.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 KOO31954.1 - 0.0086 15.5 0.2 0.021 14.3 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Bac_DnaA PF00308.13 KOO31954.1 - 0.04 13.5 0.0 0.075 12.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_23 PF13476.1 KOO31954.1 - 0.052 13.8 0.1 0.052 13.8 0.1 1.6 2 0 0 2 2 1 0 AAA domain AAA PF00004.24 KOO31954.1 - 0.074 13.2 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 KOO31954.1 - 0.091 13.5 0.0 0.091 13.5 0.0 2.3 3 0 0 3 3 2 0 AAA domain NACHT PF05729.7 KOO31954.1 - 0.1 12.2 0.0 0.43 10.2 0.0 2.0 2 0 0 2 2 2 0 NACHT domain DUF815 PF05673.8 KOO31954.1 - 0.12 11.2 0.0 0.21 10.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_22 PF13401.1 KOO31954.1 - 0.15 12.2 0.0 1 9.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain Miro PF08477.8 KOO31954.1 - 0.15 12.5 0.0 0.39 11.2 0.0 1.7 2 0 0 2 2 1 0 Miro-like protein AAA_15 PF13175.1 KOO31954.1 - 0.23 10.4 0.0 0.32 9.9 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_13 PF13166.1 KOO31954.1 - 0.57 8.5 0.0 0.94 7.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain Arm PF00514.18 KOO31955.1 - 1.4e-51 170.6 71.1 1.1e-08 34.6 0.1 20.2 21 1 0 21 21 21 13 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO31955.1 - 5.2e-09 36.2 77.5 0.0033 17.6 0.1 10.8 4 2 7 12 12 12 7 HEAT repeats Arm_2 PF04826.8 KOO31955.1 - 0.041 12.9 0.0 10 5.1 0.0 4.0 4 0 0 4 4 4 0 Armadillo-like Adaptin_N PF01602.15 KOO31955.1 - 0.1 10.8 0.1 0.64 8.2 0.0 2.0 2 0 0 2 2 2 0 Adaptin N terminal region HEAT PF02985.17 KOO31955.1 - 0.64 10.2 0.0 0.64 10.2 0.0 10.0 12 0 0 12 12 12 0 HEAT repeat Arm PF00514.18 KOO31956.1 - 1.4e-107 348.2 110.3 6.6e-06 25.7 0.1 30.6 30 2 1 31 31 31 23 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 KOO31956.1 - 4.6e-14 52.1 4.6 1.1 8.3 0.0 10.1 6 3 5 11 11 11 5 Armadillo-like HEAT_2 PF13646.1 KOO31956.1 - 5.3e-14 52.2 122.3 0.00034 20.8 3.6 15.3 4 2 11 15 15 15 10 HEAT repeats C2 PF00168.25 KOO31956.1 - 2.5e-10 40.0 0.0 2.4e-09 36.9 0.0 2.2 2 0 0 2 2 2 1 C2 domain Atx10homo_assoc PF09759.4 KOO31956.1 - 1.4e-06 27.9 3.0 0.38 10.4 0.2 6.3 6 0 0 6 6 6 2 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.1 KOO31956.1 - 0.0035 17.7 3.1 0.0035 17.7 2.1 16.4 16 4 5 21 21 21 2 HEAT-like repeat RYDR_ITPR PF01365.16 KOO31956.1 - 0.0035 16.5 0.2 0.73 9.0 0.0 2.8 2 0 0 2 2 2 1 RIH domain HEAT PF02985.17 KOO31956.1 - 0.048 13.7 0.1 0.048 13.7 0.0 14.7 17 0 0 17 17 17 0 HEAT repeat V-ATPase_H_C PF11698.3 KOO31956.1 - 0.21 11.5 0.4 32 4.4 0.0 4.3 5 0 0 5 5 5 0 V-ATPase subunit H Nipped-B_C PF12830.2 KOO31956.1 - 0.5 9.9 2.3 37 3.8 0.1 3.3 3 0 0 3 3 3 0 Sister chromatid cohesion C-terminus Nucleotid_trans PF03407.11 KOO31957.1 - 2.2e-26 92.9 0.0 3.8e-26 92.2 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase ArfGap PF01412.13 KOO31957.1 - 2e-22 79.1 0.0 1.1e-21 76.8 0.1 2.0 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PH PF00169.24 KOO31957.1 - 5.8e-06 26.4 0.0 9.9e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 PH domain Cytochrom_C552 PF02335.10 KOO31957.1 - 0.086 11.5 0.1 0.2 10.3 0.0 1.6 1 0 0 1 1 1 0 Cytochrome c552 LRR_6 PF13516.1 KOO31958.1 - 3.1e-36 119.3 6.3 0.00026 20.7 0.1 8.3 8 0 0 8 8 8 7 Leucine Rich repeat LRR_1 PF00560.28 KOO31958.1 - 4.1e-06 26.0 0.0 33 5.0 0.0 7.1 9 0 0 9 9 9 0 Leucine Rich Repeat LRR_7 PF13504.1 KOO31958.1 - 1e-05 24.9 5.4 44 4.9 0.0 7.5 8 0 0 8 8 8 0 Leucine rich repeat LRR_4 PF12799.2 KOO31958.1 - 1.7e-05 24.3 7.0 4.7 6.9 0.3 5.5 4 3 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO31958.1 - 0.0011 18.6 6.6 0.72 9.6 0.0 4.7 3 3 2 5 5 5 2 Leucine rich repeat Cyclin_N PF00134.18 KOO31961.1 - 1.2e-19 70.1 0.3 1.8e-19 69.5 0.2 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 KOO31961.1 - 1.8e-05 24.6 0.6 0.00085 19.2 0.0 2.3 2 0 0 2 2 2 2 Cyclin, C-terminal domain GLE1 PF07817.8 KOO31962.1 - 0.081 11.8 2.3 0.13 11.1 1.6 1.3 1 0 0 1 1 1 0 GLE1-like protein DUF4618 PF15397.1 KOO31962.1 - 0.21 10.8 8.9 0.2 10.9 4.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) RVT_1 PF00078.22 KOO31963.1 - 0.21 10.9 0.0 0.32 10.3 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) KIAA1430 PF13879.1 KOO31965.1 - 5.2e-15 55.6 0.3 5.2e-15 55.6 0.2 1.7 2 0 0 2 2 2 1 KIAA1430 homologue Dishevelled PF02377.10 KOO31965.1 - 0.043 14.0 2.8 0.12 12.5 1.9 1.8 1 0 0 1 1 1 0 Dishevelled specific domain DUF4315 PF14193.1 KOO31965.1 - 1 9.3 4.3 0.27 11.2 0.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4315) Chloroa_b-bind PF00504.16 KOO31966.1 - 3.8e-27 95.4 0.1 5.6e-27 94.9 0.1 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein CRAL_TRIO PF00650.15 KOO31967.1 - 3.9e-18 65.4 0.0 7.3e-18 64.5 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain GrpE PF01025.14 KOO31967.1 - 0.42 10.1 1.7 0.68 9.4 1.2 1.3 1 0 0 1 1 1 0 GrpE Rad52_Rad22 PF04098.10 KOO31968.1 - 4.4e-07 29.7 0.0 7.7e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein RRM_6 PF14259.1 KOO31968.1 - 0.074 13.0 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) PP2C PF00481.16 KOO31970.1 - 7.8e-45 153.2 0.0 9.4e-45 152.9 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 KOO31970.1 - 0.00023 20.6 0.7 0.00041 19.8 0.5 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C LRR_5 PF13306.1 KOO31971.1 - 1.4e-168 551.9 0.0 1.9e-30 105.2 0.0 5.0 1 1 5 6 6 6 6 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO31971.1 - 1.2e-44 149.9 0.0 7.4e-05 22.4 0.0 10.1 2 1 13 15 15 15 14 Leucine rich repeat Skp1 PF01466.14 KOO31971.1 - 0.052 13.5 0.0 0.089 12.8 0.0 1.3 1 0 0 1 1 1 0 Skp1 family, dimerisation domain Fork_head_N PF08430.7 KOO31971.1 - 0.53 10.6 48.4 1.5e+04 -31.4 33.5 6.0 1 1 0 1 1 1 0 Forkhead N-terminal region Pyridoxal_deC PF00282.14 KOO31972.1 - 3.4e-22 78.4 0.0 7.4e-22 77.3 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.14 KOO31972.1 - 6.1e-07 28.5 0.0 1.4e-06 27.2 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 KOO31972.1 - 3.8e-05 22.9 0.0 5.1e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DNA_photolyase PF00875.13 KOO31973.1 - 4.3e-10 39.5 0.5 2.1e-09 37.3 0.0 1.9 1 1 1 2 2 2 1 DNA photolyase SRP54 PF00448.17 KOO31973.1 - 0.066 12.6 0.0 0.093 12.1 0.0 1.1 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Succ_CoA_lig PF13607.1 KOO31973.1 - 1.2 8.7 6.3 3.1 7.4 0.0 2.3 1 1 1 2 2 2 0 Succinyl-CoA ligase like flavodoxin domain Apc5 PF12862.2 KOO31976.1 - 0.0065 16.2 0.3 3.1 7.7 0.1 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 5 MoaE PF02391.12 KOO31976.1 - 0.099 12.4 0.0 6.3 6.6 0.0 2.3 2 0 0 2 2 2 0 MoaE protein YjgF_endoribonc PF14588.1 KOO31978.1 - 4.1e-19 68.9 0.0 5.1e-19 68.6 0.0 1.1 1 0 0 1 1 1 1 YjgF/chorismate_mutase-like, putative endoribonuclease Ribonuc_L-PSP PF01042.16 KOO31978.1 - 1.4e-10 40.9 0.0 2e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Endoribonuclease L-PSP Homeobox PF00046.24 KOO31979.1 - 3.3e-12 45.8 0.1 7.7e-12 44.6 0.1 1.6 1 0 0 1 1 1 1 Homeobox domain SRA1 PF07304.6 KOO31979.1 - 1.8e-09 37.4 0.0 5.5e-09 35.9 0.0 1.8 1 0 0 1 1 1 1 Steroid receptor RNA activator (SRA1) Homeobox_KN PF05920.6 KOO31979.1 - 0.0013 18.3 0.2 0.0026 17.4 0.1 1.4 1 0 0 1 1 1 1 Homeobox KN domain DUF2723 PF11028.3 KOO31979.1 - 0.072 12.5 0.7 0.14 11.6 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2723) HMG_box PF00505.14 KOO31981.1 - 6e-27 93.7 14.1 2.5e-16 59.6 0.8 3.4 4 0 0 4 4 4 2 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO31981.1 - 2.6e-25 88.5 6.4 3.1e-15 56.2 1.0 2.6 2 0 0 2 2 2 2 HMG-box domain Imm35 PF15581.1 KOO31981.1 - 0.0055 16.6 0.0 0.2 11.6 0.0 2.4 2 0 0 2 2 2 1 Immunity protein 35 DUF2067 PF09840.4 KOO31981.1 - 0.014 14.9 0.6 0.023 14.2 0.4 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2067) HMG_box_5 PF14887.1 KOO31981.1 - 0.021 14.6 10.6 0.025 14.3 0.2 3.0 3 0 0 3 3 3 0 HMG (high mobility group) box 5 DUF1014 PF06244.7 KOO31981.1 - 0.47 10.6 8.6 0.072 13.3 1.7 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1014) Endonuc-FokI_C PF09254.6 KOO31982.1 - 0.038 13.0 0.0 0.061 12.3 0.0 1.2 1 0 0 1 1 1 0 Restriction endonuclease FokI, C terminal RYDR_ITPR PF01365.16 KOO31984.1 - 1.8e-06 27.3 0.1 7.9e-06 25.2 0.0 1.9 1 1 1 2 2 2 1 RIH domain DUF2191 PF09957.4 KOO31984.1 - 0.014 15.1 0.2 0.084 12.6 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2191) Radical_SAM PF04055.16 KOO31985.1 - 0.048 13.8 0.0 0.28 11.3 0.0 2.0 2 0 0 2 2 2 0 Radical SAM superfamily RYDR_ITPR PF01365.16 KOO31986.1 - 3.5e-22 78.6 2.1 7.3e-21 74.3 1.4 2.1 1 1 0 1 1 1 1 RIH domain Opiods_neuropep PF01160.13 KOO31986.1 - 0.062 13.0 1.6 0.081 12.7 0.2 1.9 2 0 0 2 2 2 0 Vertebrate endogenous opioids neuropeptide MIR PF02815.14 KOO31986.1 - 0.066 12.7 0.0 0.099 12.1 0.0 1.4 1 0 0 1 1 1 0 MIR domain Flu_B_M2 PF04772.7 KOO31986.1 - 0.16 12.0 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Influenza B matrix protein 2 (BM2) KH_1 PF00013.24 KOO31987.1 - 2e-37 126.6 6.4 1.4e-14 53.4 0.0 3.2 2 1 1 3 3 3 3 KH domain KH_3 PF13014.1 KOO31987.1 - 1.1e-29 101.5 10.1 2e-09 36.9 0.1 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 KOO31987.1 - 1.7e-10 40.2 3.2 0.014 14.9 0.0 3.2 3 0 0 3 3 3 3 KH domain KH_4 PF13083.1 KOO31987.1 - 2.3e-05 23.9 4.0 0.32 10.6 0.0 3.4 3 0 0 3 3 3 3 KH domain KH_5 PF13184.1 KOO31987.1 - 0.0031 17.2 2.0 3.1 7.6 0.0 3.1 3 0 0 3 3 3 2 NusA-like KH domain RIH_assoc PF08454.6 KOO31988.1 - 2.4e-18 65.7 0.7 2.4e-17 62.5 0.1 2.5 2 0 0 2 2 2 1 RyR and IP3R Homology associated Ion_trans PF00520.26 KOO31988.1 - 5.1e-05 22.6 12.1 0.00011 21.5 8.4 1.6 1 1 0 1 1 1 1 Ion transport protein MutS_III PF05192.13 KOO31988.1 - 0.0079 16.0 0.3 7.8 6.2 0.0 3.4 3 1 0 3 3 3 2 MutS domain III DUF4446 PF14584.1 KOO31988.1 - 0.03 14.1 0.6 0.12 12.1 0.4 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) CENP-F_leu_zip PF10473.4 KOO31988.1 - 0.46 10.3 10.0 0.18 11.6 4.1 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Claudin_2 PF13903.1 KOO31988.1 - 0.54 9.9 9.3 5.1 6.7 0.2 2.5 2 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Glycolytic PF00274.14 KOO31989.1 - 7.6e-138 458.6 0.0 8.9e-138 458.4 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I NHL PF01436.16 KOO31990.1 - 5.2e-26 89.2 12.1 1.9e-05 24.4 0.0 6.7 6 1 0 6 6 6 5 NHL repeat SGL PF08450.7 KOO31990.1 - 6.7e-08 32.2 0.0 0.0032 16.8 0.0 3.0 2 1 0 3 3 3 2 SMP-30/Gluconolaconase/LRE-like region PQQ_2 PF13360.1 KOO31990.1 - 1.7e-05 24.3 0.0 0.14 11.5 0.0 3.2 2 1 0 3 3 3 2 PQQ-like domain PQQ_3 PF13570.1 KOO31990.1 - 4e-05 23.7 4.4 0.16 12.3 0.2 4.9 5 1 1 6 6 6 2 PQQ-like domain Str_synth PF03088.11 KOO31990.1 - 0.083 12.9 0.0 3.7 7.6 0.0 2.8 2 1 0 2 2 2 0 Strictosidine synthase GlutR_N PF05201.10 KOO31991.1 - 8.4e-42 142.3 0.0 1.9e-41 141.1 0.0 1.7 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, N-terminal domain Shikimate_DH PF01488.15 KOO31991.1 - 4.6e-30 104.4 0.0 1.8e-29 102.5 0.0 2.1 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase GlutR_dimer PF00745.15 KOO31991.1 - 9.4e-24 83.2 0.4 2.2e-23 82.1 0.3 1.6 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, dimerisation domain F420_oxidored PF03807.12 KOO31991.1 - 0.00016 22.0 0.1 0.0013 19.1 0.0 2.6 3 0 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent KR PF08659.5 KOO31991.1 - 0.0028 17.3 2.4 0.046 13.3 0.0 2.5 2 0 0 2 2 2 1 KR domain NAD_binding_2 PF03446.10 KOO31991.1 - 0.0042 16.9 0.2 0.041 13.7 0.0 2.6 3 0 0 3 3 3 1 NAD binding domain of 6-phosphogluconate dehydrogenase GFO_IDH_MocA PF01408.17 KOO31991.1 - 0.0057 17.1 0.1 1.3 9.5 0.0 3.3 3 0 0 3 3 3 1 Oxidoreductase family, NAD-binding Rossmann fold ApbA PF02558.11 KOO31991.1 - 0.0074 15.7 0.0 0.015 14.7 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ThiF PF00899.16 KOO31991.1 - 0.019 14.7 0.1 0.068 12.9 0.0 2.0 2 0 0 2 2 2 0 ThiF family DUF1133 PF06576.6 KOO31991.1 - 0.28 10.3 1.1 0.89 8.7 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1133) SHIPPO-rpt PF07004.7 KOO31993.1 - 1.5e-05 25.6 15.2 3.1 8.8 0.1 7.1 6 1 0 6 6 6 3 Sperm-tail PG-rich repeat FliD_N PF02465.13 KOO31993.1 - 3.7 7.9 5.5 7.9 6.9 0.3 2.8 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Myb_DNA-binding PF00249.26 KOO31994.1 - 1.6e-17 63.2 0.9 1.3e-11 44.3 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO31994.1 - 1.5e-10 40.9 1.0 0.00018 21.5 0.4 2.5 1 1 1 2 2 2 2 Myb-like DNA-binding domain NDUF_B12 PF08122.7 KOO31995.1 - 7.2e-06 25.6 0.1 1.2e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family TfoX_N PF04993.8 KOO31995.1 - 0.046 13.5 0.0 0.092 12.6 0.0 1.5 1 1 1 2 2 2 0 TfoX N-terminal domain Tad PF13400.1 KOO31996.1 - 3.9 7.5 12.2 0.1 12.6 3.4 2.0 2 0 0 2 2 2 0 Putative Flp pilus-assembly TadE/G-like CytochromB561_N PF09786.4 KOO31997.1 - 1.6e-23 83.0 1.8 2.5e-22 79.1 0.1 2.6 2 1 0 2 2 2 2 Cytochrome B561, N terminal RAMP PF04901.8 KOO31999.1 - 0.056 13.1 0.3 0.11 12.2 0.2 1.4 1 0 0 1 1 1 0 Receptor activity modifying family MFS_3 PF05977.8 KOO32000.1 - 7.1e-07 27.7 24.7 1.1e-06 27.0 5.7 2.1 2 0 0 2 2 2 2 Transmembrane secretion effector LAB_N PF07578.6 KOO32000.1 - 0.017 15.0 0.1 0.055 13.3 0.1 1.9 1 0 0 1 1 1 0 Lipid A Biosynthesis N-terminal domain MFS_1 PF07690.11 KOO32000.1 - 0.65 8.6 37.3 0.071 11.8 21.0 2.1 1 1 1 2 2 2 0 Major Facilitator Superfamily Homeobox PF00046.24 KOO32001.1 - 2e-16 59.3 0.5 3.9e-16 58.3 0.3 1.5 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 KOO32001.1 - 9.9e-05 21.9 0.0 0.00027 20.5 0.0 1.8 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.3 KOO32001.1 - 0.53 9.3 4.6 0.21 10.7 0.2 2.2 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez CH PF00307.26 KOO32002.1 - 1.9e-12 47.1 0.1 1.3e-06 28.4 0.0 3.1 2 1 0 2 2 2 2 Calponin homology (CH) domain LRR_6 PF13516.1 KOO32003.1 - 2.5e-11 42.4 0.0 0.33 11.1 0.0 6.9 7 1 0 7 7 7 3 Leucine Rich repeat LRR_4 PF12799.2 KOO32003.1 - 1.9e-05 24.1 0.0 0.084 12.5 0.0 4.1 2 2 2 5 5 5 2 Leucine Rich repeats (2 copies) ART PF01129.13 KOO32003.1 - 0.00077 18.6 0.0 0.0014 17.7 0.0 1.3 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase LRR_8 PF13855.1 KOO32003.1 - 0.0019 17.9 0.1 0.3 10.8 0.0 3.2 1 1 2 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 KOO32003.1 - 0.0097 15.8 0.3 33 5.0 0.0 4.6 4 1 0 4 4 4 0 Leucine Rich Repeat LRR_7 PF13504.1 KOO32003.1 - 0.013 15.5 4.3 19 6.0 0.0 5.4 6 0 0 6 6 6 0 Leucine rich repeat ATG16 PF08614.6 KOO32004.1 - 0.0098 15.7 3.2 0.0098 15.7 2.2 4.3 2 1 2 4 4 4 1 Autophagy protein 16 (ATG16) Vps52 PF04129.7 KOO32004.1 - 0.021 13.3 0.2 0.021 13.3 0.2 1.6 2 0 0 2 2 2 0 Vps52 / Sac2 family Tropomyosin_1 PF12718.2 KOO32004.1 - 0.069 12.9 64.2 0.44 10.4 0.7 5.5 2 1 3 5 5 5 0 Tropomyosin like BLOC1_2 PF10046.4 KOO32004.1 - 0.12 12.4 16.6 0.054 13.6 0.5 4.7 4 1 0 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Reo_sigmaC PF04582.7 KOO32004.1 - 1.2 8.2 24.2 2.3 7.3 0.5 4.1 3 1 1 4 4 4 0 Reovirus sigma C capsid protein Spc7 PF08317.6 KOO32004.1 - 3.6 6.1 40.5 0.43 9.2 1.0 4.2 2 1 0 4 4 4 0 Spc7 kinetochore protein EF-hand_5 PF13202.1 KOO32005.1 - 1.1e-10 40.3 0.7 0.00048 19.3 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO32005.1 - 1.6e-10 39.9 6.1 0.00031 20.3 0.4 3.9 3 1 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 KOO32005.1 - 7.8e-10 38.2 8.2 0.0003 20.3 0.2 3.9 2 1 1 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO32005.1 - 8e-10 37.3 11.7 0.00014 20.8 0.1 4.6 5 0 0 5 5 5 2 EF hand EF-hand_7 PF13499.1 KOO32005.1 - 1.9e-09 37.4 4.9 0.00094 19.2 0.1 2.9 2 1 1 3 3 3 2 EF-hand domain pair DUF1456 PF07308.8 KOO32005.1 - 0.035 14.1 3.2 0.13 12.3 0.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1456) Op_neuropeptide PF08035.6 KOO32005.1 - 0.096 12.2 0.0 0.3 10.7 0.0 1.8 1 0 0 1 1 1 0 Opioids neuropeptide FKBP_N PF01346.13 KOO32005.1 - 0.92 9.5 4.8 1.9 8.5 0.2 2.6 1 1 1 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase DUF3008 PF11450.3 KOO32005.1 - 1.8 8.7 6.5 9 6.5 0.2 3.1 4 0 0 4 4 4 0 Protein of unknwon function (DUF3008) His_Phos_1 PF00300.17 KOO32006.1 - 2.9e-10 40.4 0.0 4.3e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Tubulin PF00091.20 KOO32006.1 - 0.00099 18.9 0.3 0.0015 18.3 0.2 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain HA2 PF04408.18 KOO32007.1 - 1.2e-18 66.9 0.3 2.9e-18 65.7 0.2 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.26 KOO32007.1 - 7.2e-11 41.7 0.1 2.1e-10 40.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain TPR_12 PF13424.1 KOO32007.1 - 7.3e-10 38.6 10.4 3.5e-05 23.6 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat DEAD PF00270.24 KOO32007.1 - 4.1e-07 29.6 0.0 7.6e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase OB_NTP_bind PF07717.11 KOO32007.1 - 1.2e-06 28.3 0.0 2.8e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold TPR_11 PF13414.1 KOO32007.1 - 4.8e-05 22.9 6.8 0.18 11.4 0.0 3.9 3 1 0 3 3 3 2 TPR repeat AAA_22 PF13401.1 KOO32007.1 - 0.0029 17.7 0.0 0.0083 16.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain zf-met PF12874.2 KOO32007.1 - 0.0046 17.1 0.2 0.01 16.0 0.2 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type Peptidase_S26 PF10502.4 KOO32007.1 - 0.015 14.7 0.0 0.13 11.7 0.0 2.4 2 0 0 2 2 2 0 Signal peptidase, peptidase S26 TPR_8 PF13181.1 KOO32007.1 - 0.059 13.1 0.6 5.3 7.0 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat KaiC PF06745.8 KOO32007.1 - 0.32 10.0 0.0 0.6 9.1 0.0 1.4 1 0 0 1 1 1 0 KaiC zf-C2H2_jaz PF12171.3 KOO32007.1 - 0.49 10.5 0.1 0.92 9.7 0.1 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding TPR_1 PF00515.23 KOO32007.1 - 0.52 10.0 6.3 7 6.4 0.0 4.4 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO32007.1 - 3.6 7.7 22.2 0.061 13.2 0.2 5.6 6 0 0 6 6 5 0 Tetratricopeptide repeat RVT_2 PF07727.9 KOO32009.1 - 5e-10 38.7 0.0 7.6e-10 38.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KOO32009.1 - 0.0022 18.1 0.0 0.0061 16.6 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Ank_2 PF12796.2 KOO32011.1 - 1.7e-22 79.5 6.1 4.7e-15 55.6 0.6 3.9 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO32011.1 - 8.8e-19 66.3 17.2 8e-05 22.2 0.2 5.6 5 0 0 5 5 5 4 Ankyrin repeat LRR_8 PF13855.1 KOO32011.1 - 1.3e-18 66.4 15.2 6.9e-08 32.1 0.4 2.8 1 1 3 4 4 4 4 Leucine rich repeat Ank_4 PF13637.1 KOO32011.1 - 3.5e-17 62.3 4.2 6.4e-08 32.9 0.2 4.7 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO32011.1 - 1.8e-15 56.6 13.1 9.2e-09 35.2 1.4 5.3 2 1 3 5 5 5 4 Ankyrin repeats (many copies) LRR_4 PF12799.2 KOO32011.1 - 1.5e-13 50.0 1.5 7.6e-05 22.2 0.0 3.8 1 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO32011.1 - 3.3e-11 41.5 1.0 0.027 14.4 0.0 5.9 6 0 0 6 6 5 3 Leucine Rich Repeat C2 PF00168.25 KOO32011.1 - 4.1e-09 36.1 0.0 6.5e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 C2 domain Ank_3 PF13606.1 KOO32011.1 - 8.7e-09 34.7 8.1 0.047 13.9 0.0 5.6 6 0 0 6 6 6 3 Ankyrin repeat LRR_7 PF13504.1 KOO32011.1 - 3.8e-05 23.1 9.1 0.86 10.0 0.1 6.2 6 0 0 6 6 6 1 Leucine rich repeat LRR_6 PF13516.1 KOO32011.1 - 0.00017 21.3 0.3 9 6.7 0.0 5.2 5 0 0 5 5 5 1 Leucine Rich repeat Rdx PF10262.4 KOO32011.1 - 0.15 12.1 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 Rdx family DnaB_bind PF10410.4 KOO32012.1 - 0.014 15.3 0.6 0.11 12.4 0.0 2.6 3 0 0 3 3 3 0 DnaB-helicase binding domain of primase KIAA1430 PF13879.1 KOO32014.1 - 2.8e-09 37.2 0.2 4.7e-09 36.5 0.1 1.5 1 1 0 1 1 1 1 KIAA1430 homologue LRR_6 PF13516.1 KOO32017.1 - 1.9e-05 24.2 0.3 0.52 10.5 0.1 5.2 5 0 0 5 5 5 2 Leucine Rich repeat Kelch_1 PF01344.20 KOO32018.1 - 1.1e-76 252.1 0.0 1.5e-14 53.2 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.1 KOO32018.1 - 3.4e-51 169.3 0.0 3.9e-12 45.7 0.0 6.6 4 1 2 6 6 6 6 Kelch motif Kelch_4 PF13418.1 KOO32018.1 - 5.3e-40 134.9 0.0 4.4e-10 39.1 0.0 6.6 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.1 KOO32018.1 - 1.2e-38 130.4 4.2 2.7e-08 33.7 0.0 6.7 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.10 KOO32018.1 - 1.2e-36 123.0 0.0 1.2e-08 34.4 0.0 6.6 6 0 0 6 6 6 5 Kelch motif DUF1350 PF07082.6 KOO32018.1 - 2.4e-23 82.5 0.0 4.3e-23 81.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1350) BACK PF07707.10 KOO32018.1 - 4.6e-17 61.7 0.0 8.8e-17 60.8 0.0 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_5 PF13854.1 KOO32018.1 - 8.1e-16 57.5 0.3 0.021 14.7 0.0 6.4 6 0 0 6 6 6 4 Kelch motif BTB PF00651.26 KOO32018.1 - 9.6e-14 51.3 0.0 1.5e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF1668 PF07893.8 KOO32018.1 - 0.00011 21.5 0.6 1.3 8.0 0.0 4.5 1 1 4 5 5 5 1 Protein of unknown function (DUF1668) Skp1 PF01466.14 KOO32018.1 - 0.035 14.1 0.2 0.076 13.0 0.1 1.5 1 0 0 1 1 1 0 Skp1 family, dimerisation domain OMP_b-brl PF13505.1 KOO32018.1 - 8.3 6.3 7.4 24 4.8 0.2 3.6 5 0 0 5 5 5 0 Outer membrane protein beta-barrel domain Con-6 PF10346.4 KOO32020.1 - 0.059 12.7 10.4 27 4.2 0.0 6.4 2 2 5 7 7 7 0 Conidiation protein 6 DEAD PF00270.24 KOO32021.1 - 2e-39 134.8 0.0 3e-39 134.1 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase SPRY PF00622.23 KOO32021.1 - 6e-17 61.8 0.0 1e-16 61.1 0.0 1.3 1 0 0 1 1 1 1 SPRY domain CMS1 PF14617.1 KOO32021.1 - 0.14 11.2 0.5 0.63 9.0 0.0 1.9 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit zf-CGNR PF11706.3 KOO32022.1 - 0.028 13.9 4.3 0.063 12.7 3.0 1.6 1 0 0 1 1 1 0 CGNR zinc finger PQQ_2 PF13360.1 KOO32022.1 - 0.037 13.5 0.0 0.21 11.0 0.0 2.0 2 0 0 2 2 2 0 PQQ-like domain adh_short PF00106.20 KOO32023.1 - 4.6e-20 72.1 0.1 6.6e-20 71.6 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KOO32023.1 - 7.1e-10 39.0 0.0 9.6e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KOO32023.1 - 8e-07 28.8 0.0 1.2e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 KOO32023.1 - 0.0017 17.2 0.0 0.0022 16.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.3 KOO32023.1 - 0.0069 16.1 0.0 0.019 14.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_10 PF13460.1 KOO32023.1 - 0.015 15.2 0.2 0.048 13.6 0.1 1.8 2 0 0 2 2 2 0 NADH(P)-binding DUF1776 PF08643.5 KOO32023.1 - 0.021 13.9 0.0 0.053 12.6 0.0 1.6 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) tRNA_SAD PF07973.9 KOO32024.1 - 6.3e-10 38.7 0.7 1.1e-09 38.0 0.5 1.4 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.14 KOO32024.1 - 0.0066 14.7 0.0 0.0092 14.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) DnaJ PF00226.26 KOO32026.1 - 2.2e-14 52.9 0.1 5.1e-14 51.7 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain Costars PF14705.1 KOO32026.1 - 0.0043 16.9 0.0 0.0077 16.1 0.0 1.4 1 0 0 1 1 1 1 Costars Trypan_PARP PF05887.6 KOO32027.1 - 0.013 15.2 5.1 0.019 14.8 3.5 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Dak2 PF02734.12 KOO32027.1 - 0.072 12.7 5.2 0.095 12.3 3.6 1.1 1 0 0 1 1 1 0 DAK2 domain 5TM-5TMR_LYT PF07694.7 KOO32027.1 - 0.15 11.3 0.1 0.19 11.0 0.1 1.1 1 0 0 1 1 1 0 5TMR of 5TMR-LYT RanGAP1_C PF07834.6 KOO32027.1 - 0.22 10.9 0.0 0.22 10.9 0.0 1.6 2 0 0 2 2 2 0 RanGAP1 C-terminal domain DUF2937 PF11157.3 KOO32028.1 - 0.0032 16.7 3.7 0.017 14.4 0.7 2.7 2 1 1 3 3 3 2 Protein of unknown function (DUF2937) O-FucT PF10250.4 KOO32029.1 - 1.3e-08 34.3 0.0 1.9e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase BphX PF06139.7 KOO32030.1 - 0.21 11.1 16.9 1.3 8.6 0.2 4.3 3 1 1 4 4 4 0 BphX-like DUF2730 PF10805.3 KOO32031.1 - 0.1 12.3 6.5 0.75 9.5 0.4 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) Macoilin PF09726.4 KOO32031.1 - 5 5.2 8.6 0.32 9.2 2.6 1.5 2 0 0 2 2 2 0 Transmembrane protein TPT PF03151.11 KOO32033.1 - 3.4e-22 78.7 4.5 4.8e-22 78.2 3.1 1.2 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.15 KOO32033.1 - 0.0028 17.6 5.9 0.0028 17.6 4.1 1.6 2 0 0 2 2 2 1 EamA-like transporter family UAA PF08449.6 KOO32033.1 - 0.013 14.4 5.1 0.017 14.0 3.5 1.1 1 0 0 1 1 1 0 UAA transporter family HCaRG PF07258.9 KOO32034.1 - 6e-27 94.3 0.2 7.2e-27 94.0 0.2 1.1 1 0 0 1 1 1 1 HCaRG protein DUF2042 PF09743.4 KOO32035.1 - 3.6e-78 262.6 0.0 4.4e-78 262.3 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2042) HTH_27 PF13463.1 KOO32035.1 - 0.0038 17.5 0.1 0.24 11.7 0.0 2.8 3 0 0 3 3 3 1 Winged helix DNA-binding domain MarR PF01047.17 KOO32035.1 - 0.017 14.8 0.0 3.5 7.4 0.0 3.2 3 0 0 3 3 3 0 MarR family HTH_9 PF08221.6 KOO32035.1 - 0.049 13.5 0.0 0.18 11.7 0.0 2.0 1 1 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain RCC1 PF00415.13 KOO32036.1 - 1.4e-46 156.4 37.5 2.3e-07 30.8 1.1 7.5 8 0 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO32036.1 - 2.5e-39 132.0 49.9 1.8e-06 27.3 0.6 7.3 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat DUF1614 PF07758.6 KOO32036.1 - 0.0016 18.2 17.6 9.3 5.9 0.2 6.0 2 2 3 6 6 6 4 Protein of unknown function (DUF1614) TM140 PF14985.1 KOO32036.1 - 1.1 8.8 4.8 40 3.8 0.0 4.0 4 1 0 5 5 5 0 TM140 protein family TIR_2 PF13676.1 KOO32038.1 - 2.3e-08 34.1 0.0 4.9e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 TIR domain TIR PF01582.15 KOO32038.1 - 0.016 14.6 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 TIR domain Nucleotid_trans PF03407.11 KOO32039.1 - 1.5e-09 37.9 0.0 9.8e-09 35.2 0.0 2.2 2 0 0 2 2 2 1 Nucleotide-diphospho-sugar transferase NDK PF00334.14 KOO32039.1 - 4.9e-05 23.1 0.0 0.0018 18.0 0.0 2.1 1 1 1 2 2 2 1 Nucleoside diphosphate kinase NMT_C PF02799.10 KOO32039.1 - 0.23 10.8 0.0 0.35 10.2 0.0 1.2 1 0 0 1 1 1 0 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Glyco_transf_34 PF05637.7 KOO32040.1 - 0.021 14.3 0.1 0.037 13.5 0.1 1.3 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family BSP_II PF05432.6 KOO32040.1 - 3 7.0 8.9 4.3 6.5 3.9 2.0 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) TB2_DP1_HVA22 PF03134.14 KOO32041.1 - 9e-17 60.6 0.1 9e-17 60.6 0.1 1.9 2 0 0 2 2 2 1 TB2/DP1, HVA22 family C2 PF00168.25 KOO32041.1 - 2.8e-08 33.5 0.0 7.7e-05 22.4 0.0 2.9 2 1 0 2 2 2 2 C2 domain PDZ PF00595.19 KOO32041.1 - 1.8e-06 28.0 0.1 3.3e-06 27.1 0.1 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) UbiA PF01040.13 KOO32042.1 - 0.0031 16.7 6.2 0.0031 16.7 4.3 2.1 2 0 0 2 2 2 1 UbiA prenyltransferase family LBR_tudor PF09465.5 KOO32042.1 - 0.01 15.4 1.5 0.14 11.8 0.1 2.5 2 0 0 2 2 2 0 Lamin-B receptor of TUDOR domain EF-hand_1 PF00036.27 KOO32044.1 - 0.00033 19.7 0.5 0.00081 18.5 0.3 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO32044.1 - 0.0016 18.5 0.0 0.0054 16.8 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO32044.1 - 0.0027 17.4 0.2 0.0092 15.7 0.1 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.1 KOO32044.1 - 0.0038 16.5 0.1 0.011 15.0 0.0 1.8 1 0 0 1 1 1 1 EF hand Caleosin PF05042.8 KOO32044.1 - 0.11 12.0 0.0 0.27 10.7 0.0 1.6 1 0 0 1 1 1 0 Caleosin related protein Reo_sigmaC PF04582.7 KOO32044.1 - 7.7 5.5 9.5 1.2 8.2 1.2 2.5 2 2 0 2 2 2 0 Reovirus sigma C capsid protein HAD_2 PF13419.1 KOO32045.1 - 3.3e-16 60.0 0.1 4e-16 59.7 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOO32045.1 - 3.4e-05 23.4 0.1 5.9e-05 22.7 0.1 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Na_sulph_symp PF00939.14 KOO32046.1 - 3.1e-62 210.9 8.3 1.4e-61 208.8 5.7 1.7 1 1 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.11 KOO32046.1 - 1.3e-07 30.5 21.9 3.9e-06 25.6 6.2 2.4 3 0 0 3 3 3 2 Citrate transporter DcuC PF03606.10 KOO32046.1 - 0.085 11.0 12.6 0.15 10.2 8.7 1.3 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier DUF485 PF04341.7 KOO32046.1 - 1 9.1 6.8 0.073 12.7 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF485 tRNA-synt_1d PF00750.14 KOO32047.1 - 2.8e-102 342.1 0.0 3.4e-102 341.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.10 KOO32047.1 - 7.5e-29 100.0 0.2 1.9e-28 98.8 0.2 1.7 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.11 KOO32047.1 - 5.5e-24 84.5 0.0 2.5e-23 82.3 0.0 2.1 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1g PF09334.6 KOO32047.1 - 0.31 9.6 0.0 0.48 9.0 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (M) EF-hand_7 PF13499.1 KOO32048.1 - 3.6e-20 71.8 3.8 1.6e-09 37.7 0.0 4.4 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO32048.1 - 7.7e-18 62.3 9.5 0.0028 16.8 0.0 5.9 6 0 0 6 6 6 4 EF hand EF-hand_5 PF13202.1 KOO32048.1 - 8.7e-17 59.6 0.5 2.3e-05 23.5 0.0 4.9 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO32048.1 - 7.8e-14 50.2 9.8 0.0042 16.8 0.0 6.5 6 1 0 6 6 6 5 EF-hand domain EF-hand_8 PF13833.1 KOO32048.1 - 4.9e-09 35.6 2.9 0.12 12.0 0.0 5.7 5 0 0 5 5 5 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO32048.1 - 1e-05 25.5 0.0 0.0088 16.0 0.0 3.3 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region Ion_trans PF00520.26 KOO32049.1 - 2.8e-17 62.6 5.3 3.6e-17 62.2 3.7 1.1 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.24 KOO32049.1 - 1.9e-10 40.3 0.0 4.5e-10 39.2 0.0 1.7 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.11 KOO32049.1 - 2.6e-08 33.4 2.2 5.6e-08 32.3 1.5 1.6 1 0 0 1 1 1 1 Ion channel TFIID-31kDa PF02291.10 KOO32050.1 - 1.4e-15 57.1 0.6 7.5e-15 54.8 0.4 2.0 1 1 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit HEAT_2 PF13646.1 KOO32051.1 - 0.034 14.4 0.2 0.045 14.0 0.1 1.3 1 0 0 1 1 1 0 HEAT repeats DUF1517 PF07466.6 KOO32052.1 - 8.4e-34 116.8 0.0 4.1e-33 114.6 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1517) DUF4047 PF13256.1 KOO32055.1 - 0.21 11.5 2.8 0.29 11.0 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) SPX PF03105.14 KOO32056.1 - 2.1e-14 54.0 0.8 3.9e-07 30.1 0.0 2.8 2 1 0 2 2 2 2 SPX domain zf-C3HC4 PF00097.20 KOO32056.1 - 8.2e-08 31.7 8.3 8.2e-08 31.7 5.8 2.3 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO32056.1 - 2.6e-07 30.3 10.9 2.6e-07 30.3 7.6 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 KOO32056.1 - 4.1e-07 29.9 10.1 4.1e-07 29.9 7.0 2.3 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 KOO32056.1 - 7e-07 29.0 9.2 7e-07 29.0 6.4 2.1 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.1 KOO32056.1 - 2.4e-06 27.0 7.1 2.4e-06 27.0 4.9 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO32056.1 - 0.00019 21.0 9.0 0.00019 21.0 6.2 2.3 2 1 0 2 2 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 KOO32056.1 - 0.0018 17.9 2.7 0.0018 17.9 1.9 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_6 PF14835.1 KOO32056.1 - 0.012 15.3 4.4 0.012 15.3 3.1 2.1 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-Apc11 PF12861.2 KOO32056.1 - 0.038 13.8 1.8 0.095 12.5 1.2 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_clus PF00172.13 KOO32056.1 - 0.076 12.9 13.5 0.24 11.3 9.3 1.9 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain HlyIII PF03006.15 KOO32057.1 - 2.3e-27 95.8 14.5 1.2e-26 93.4 10.0 1.9 1 1 0 1 1 1 1 Haemolysin-III related GCC2_GCC3 PF07699.8 KOO32058.1 - 1.4e-08 34.1 15.9 5.3e-06 25.9 4.2 3.2 1 1 2 3 3 3 2 GCC2 and GCC3 NCD3G PF07562.9 KOO32058.1 - 0.0014 18.2 1.3 0.0014 18.2 0.9 2.1 1 1 1 2 2 2 2 Nine Cysteines Domain of family 3 GPCR LRR_6 PF13516.1 KOO32059.1 - 0.0049 16.7 0.0 4.4 7.6 0.0 2.4 2 0 0 2 2 2 2 Leucine Rich repeat CWC25 PF12542.3 KOO32059.1 - 0.013 15.9 0.0 0.019 15.3 0.0 1.4 1 1 0 1 1 1 0 Pre-mRNA splicing factor LRR_7 PF13504.1 KOO32059.1 - 0.13 12.5 0.0 0.38 11.1 0.0 1.7 1 0 0 1 1 1 0 Leucine rich repeat Cnd2 PF05786.9 KOO32061.1 - 9e-33 113.7 4.5 1.6e-10 40.1 1.0 4.4 2 2 2 4 4 4 4 Condensin complex subunit 2 Trypan_PARP PF05887.6 KOO32061.1 - 4.9e-05 23.1 21.7 4.9e-05 23.1 15.0 3.1 3 0 0 3 3 3 1 Procyclic acidic repetitive protein (PARP) Phage_Gp14 PF10666.4 KOO32061.1 - 0.053 13.3 2.1 0.37 10.6 0.2 2.3 2 0 0 2 2 2 0 Phage protein Gp14 Transketolase_N PF00456.16 KOO32062.1 - 2.5e-145 483.4 0.0 3.2e-145 483.1 0.0 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.19 KOO32062.1 - 2.3e-40 138.0 0.0 4e-40 137.2 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain DXP_synthase_N PF13292.1 KOO32062.1 - 0.00017 20.6 0.0 0.0028 16.6 0.0 2.1 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.15 KOO32062.1 - 0.0012 17.6 0.0 0.0018 17.0 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.16 KOO32062.1 - 0.027 14.0 1.3 0.18 11.3 0.5 2.5 1 1 1 2 2 2 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Nodulin-like PF06813.8 KOO32063.1 - 4e-18 65.5 5.4 8.4e-18 64.5 3.8 1.5 1 0 0 1 1 1 1 Nodulin-like MFS_1 PF07690.11 KOO32063.1 - 3e-12 45.9 36.1 3e-12 45.9 25.0 1.8 2 1 0 2 2 2 1 Major Facilitator Superfamily RVT_1 PF00078.22 KOO32064.1 - 0.0026 17.1 0.0 0.0046 16.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PITH PF06201.8 KOO32065.1 - 1.6e-40 138.3 0.0 1.9e-40 138.1 0.0 1.0 1 0 0 1 1 1 1 PITH domain TPT PF03151.11 KOO32067.1 - 1.3e-28 99.5 9.8 1.3e-28 99.5 6.8 2.9 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 KOO32067.1 - 1.1e-06 28.6 29.6 0.00089 19.2 10.1 2.2 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.6 KOO32067.1 - 0.008 15.1 20.1 0.17 10.7 13.9 2.2 1 1 0 1 1 1 1 UAA transporter family DUF533 PF04391.7 KOO32067.1 - 0.07 12.5 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF533) peroxidase PF00141.18 KOO32068.1 - 7.5e-47 159.7 0.0 1.1e-46 159.2 0.0 1.2 1 0 0 1 1 1 1 Peroxidase SAP PF02037.22 KOO32069.1 - 1.7e-20 71.9 10.4 2.9e-11 42.5 1.1 4.0 4 1 1 5 5 5 2 SAP domain Telomere_Sde2_2 PF13297.1 KOO32069.1 - 0.04 13.1 1.4 0.3 10.3 0.6 2.2 2 0 0 2 2 2 0 Telomere stability C-terminal SAP30_Sin3_bdg PF13867.1 KOO32069.1 - 0.045 13.6 0.0 0.38 10.6 0.0 2.5 2 0 0 2 2 2 0 Sin3 binding region of histone deacetylase complex subunit SAP30 UPF0118 PF01594.11 KOO32070.1 - 2.7e-10 39.7 10.3 2.7e-10 39.7 7.1 2.5 3 0 0 3 3 3 1 Domain of unknown function DUF20 Spc97_Spc98 PF04130.8 KOO32071.1 - 2.7e-68 230.6 1.2 3.1e-45 154.5 0.4 2.5 2 1 1 3 3 3 2 Spc97 / Spc98 family Methyltransf_16 PF10294.4 KOO32071.1 - 7.5e-08 32.0 0.0 1.4e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase EF-hand_5 PF13202.1 KOO32072.1 - 6.2e-09 34.7 0.1 0.0019 17.4 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.27 KOO32072.1 - 7e-09 34.3 0.3 0.0027 16.8 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO32072.1 - 1.2e-08 34.9 0.0 0.00062 19.8 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO32072.1 - 3.3e-08 32.7 0.9 0.0071 16.1 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 KOO32072.1 - 1.3e-07 31.0 0.4 1e-06 28.2 0.3 2.2 2 0 0 2 2 2 1 EF-hand domain pair Polyketide_cyc PF03364.15 KOO32072.1 - 0.0022 17.9 0.0 0.0039 17.1 0.0 1.4 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport HRDC PF00570.18 KOO32073.1 - 3e-10 39.6 0.0 6.4e-10 38.6 0.0 1.6 1 0 0 1 1 1 1 HRDC domain HHH PF00633.18 KOO32073.1 - 0.042 13.5 1.5 6.9 6.5 0.0 4.3 5 0 0 5 5 5 0 Helix-hairpin-helix motif dNK PF01712.14 KOO32074.1 - 1.3e-19 70.5 0.0 1.7e-19 70.1 0.0 1.1 1 0 0 1 1 1 1 Deoxynucleoside kinase Thymidylate_kin PF02223.12 KOO32074.1 - 1.3e-07 31.1 0.0 2.2e-07 30.4 0.0 1.3 1 1 0 1 1 1 1 Thymidylate kinase Herpes_TK PF00693.13 KOO32074.1 - 0.053 12.6 0.1 0.15 11.1 0.0 1.7 2 0 0 2 2 2 0 Thymidine kinase from herpesvirus DUF2703 PF10865.3 KOO32074.1 - 0.057 13.3 0.1 2.9 7.8 0.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF2703) FKBP_C PF00254.23 KOO32075.1 - 4.2e-07 29.8 0.0 5.7e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase PDZ PF00595.19 KOO32076.1 - 0.00013 22.0 0.0 0.0014 18.7 0.0 2.6 2 1 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) TrbI PF03743.9 KOO32076.1 - 0.98 8.8 4.1 14 5.1 0.0 2.7 3 0 0 3 3 3 0 Bacterial conjugation TrbI-like protein Ribosomal_L17 PF01196.14 KOO32077.1 - 5.5e-33 113.4 0.9 8.6e-33 112.7 0.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L17 DUF2785 PF10978.3 KOO32077.1 - 0.15 11.5 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2785) NAD_binding_1 PF00175.16 KOO32078.1 - 2.9e-22 79.2 0.0 4.4e-22 78.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 KOO32078.1 - 2.6e-15 56.3 0.0 5.6e-15 55.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 KOO32078.1 - 0.00042 20.2 0.0 0.0047 16.8 0.0 2.1 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.6 KOO32078.1 - 0.06 13.3 0.0 0.099 12.6 0.0 1.3 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain GMC_oxred_N PF00732.14 KOO32081.1 - 1.5e-64 218.0 0.0 2.4e-64 217.3 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 KOO32081.1 - 1.5e-34 119.3 0.0 2.3e-34 118.7 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.19 KOO32081.1 - 1.9e-08 33.6 0.8 8.1e-07 28.2 0.1 2.6 3 0 0 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 KOO32081.1 - 1.5e-06 27.3 4.5 0.0001 21.2 1.1 2.3 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.1 KOO32081.1 - 1e-05 25.4 1.5 3.9e-05 23.6 1.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 KOO32081.1 - 0.0012 17.9 0.2 0.0017 17.3 0.2 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.12 KOO32081.1 - 0.0015 17.6 0.2 0.0024 16.9 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.9 KOO32081.1 - 0.0043 16.9 0.9 0.0085 15.9 0.3 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.11 KOO32081.1 - 0.0047 16.3 1.5 0.0093 15.4 1.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA HI0933_like PF03486.9 KOO32081.1 - 0.012 14.0 0.8 0.02 13.3 0.6 1.3 1 0 0 1 1 1 0 HI0933-like protein GIDA PF01134.17 KOO32081.1 - 0.016 14.1 1.2 0.021 13.6 0.8 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_3 PF01494.14 KOO32081.1 - 0.057 12.4 0.8 0.086 11.8 0.6 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.1 KOO32081.1 - 0.091 12.8 0.2 0.2 11.7 0.2 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.16 KOO32081.1 - 0.13 12.0 0.6 0.27 11.0 0.4 1.5 1 0 0 1 1 1 0 ThiF family Pyr_redox PF00070.22 KOO32081.1 - 0.23 11.8 0.5 0.52 10.7 0.4 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF1712 PF08217.6 KOO32082.1 - 1.6e-28 99.3 0.0 2.8e-23 82.0 0.0 3.0 2 1 1 3 3 3 3 Fungal domain of unknown function (DUF1712) Ribosomal_L22e PF01776.12 KOO32083.1 - 3e-50 168.8 3.1 3.7e-50 168.6 2.2 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family Red1 PF07964.6 KOO32083.1 - 0.031 12.4 0.7 0.034 12.3 0.5 1.0 1 0 0 1 1 1 0 Rec10 / Red1 FmdA_AmdA PF03069.10 KOO32084.1 - 6.1e-79 265.3 0.0 6.9e-79 265.1 0.0 1.0 1 0 0 1 1 1 1 Acetamidase/Formamidase family DUF4568 PF15132.1 KOO32084.1 - 0.15 11.2 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4568) DUF1092 PF06485.6 KOO32085.1 - 2.3e-80 269.4 0.0 2.7e-80 269.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1092) HABP4_PAI-RBP1 PF04774.10 KOO32086.1 - 0.056 13.9 1.3 0.084 13.3 0.9 1.2 1 0 0 1 1 1 0 Hyaluronan / mRNA binding family FKBP_C PF00254.23 KOO32087.1 - 4.8e-48 161.1 0.0 4.9e-13 48.9 0.0 5.6 5 0 0 5 5 5 4 FKBP-type peptidyl-prolyl cis-trans isomerase Pro_isomerase PF00160.16 KOO32087.1 - 2.5e-40 138.2 0.0 4.6e-40 137.3 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_11 PF13414.1 KOO32087.1 - 5.3e-23 80.4 19.2 1.9e-06 27.3 0.7 5.6 5 1 0 5 5 5 4 TPR repeat TPR_1 PF00515.23 KOO32087.1 - 2.9e-09 36.1 26.0 0.0037 16.8 0.2 7.5 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO32087.1 - 1.3e-08 34.1 28.9 0.03 14.2 0.2 7.4 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.1 KOO32087.1 - 3.7e-08 33.8 11.8 0.017 15.7 0.9 4.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO32087.1 - 7.5e-05 22.2 10.0 0.016 14.9 0.4 4.7 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO32087.1 - 0.00057 19.7 18.7 0.016 15.1 1.2 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO32087.1 - 0.0035 17.4 0.2 0.26 11.5 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO32087.1 - 0.026 14.8 22.7 0.035 14.4 1.8 5.1 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO32087.1 - 0.065 13.8 16.0 0.29 11.8 0.2 5.4 6 0 0 6 6 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO32087.1 - 0.076 12.9 5.7 3.9 7.4 0.1 3.8 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.1 KOO32087.1 - 0.091 13.2 8.2 1.6 9.3 1.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO32087.1 - 0.39 10.6 7.7 4.7 7.1 0.2 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.13 KOO32087.1 - 2.7 7.9 8.3 2.1 8.2 0.2 3.7 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_7 PF13176.1 KOO32087.1 - 3.4 7.6 13.4 12 5.9 0.2 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat PYRIN PF02758.11 KOO32088.1 - 0.051 13.2 0.2 0.31 10.7 0.1 2.1 2 0 0 2 2 2 0 PAAD/DAPIN/Pyrin domain Metallophos PF00149.23 KOO32090.1 - 1e-11 44.6 0.0 1.8e-11 43.8 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 KOO32090.1 - 1.1e-05 25.3 0.0 1.5e-05 24.8 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain 3HCDH PF00725.17 KOO32092.1 - 7.6e-30 103.1 0.0 9.2e-21 74.0 0.0 2.4 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 3HCDH_N PF02737.13 KOO32092.1 - 9.5e-30 103.5 1.9 3.7e-29 101.6 0.8 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Kinesin PF00225.18 KOO32093.1 - 7.6e-97 324.0 0.2 1.3e-96 323.2 0.0 1.4 2 0 0 2 2 2 1 Kinesin motor domain AAA_22 PF13401.1 KOO32093.1 - 0.069 13.2 1.9 0.13 12.4 0.0 2.2 2 1 0 2 2 2 0 AAA domain HlyD PF00529.15 KOO32093.1 - 0.087 12.1 22.3 0.17 11.2 15.5 1.4 1 0 0 1 1 1 0 HlyD family secretion protein DUF4407 PF14362.1 KOO32093.1 - 0.76 8.6 15.1 1.4 7.7 10.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PV-1 PF06637.6 KOO32093.1 - 0.79 8.2 16.9 1.2 7.5 11.7 1.3 1 0 0 1 1 1 0 PV-1 protein (PLVAP) IncA PF04156.9 KOO32093.1 - 3.7 7.0 23.1 2.1 7.9 13.0 2.2 1 1 1 2 2 2 0 IncA protein APG6 PF04111.7 KOO32093.1 - 6.2 5.7 16.6 9.8 5.1 11.5 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 AAA_12 PF13087.1 KOO32094.1 - 6.3e-29 100.7 0.0 9.6e-29 100.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 KOO32094.1 - 2.2e-23 83.1 0.0 1.2e-22 80.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain WW PF00397.21 KOO32094.1 - 7.6e-08 32.0 8.4 4.3e-05 23.2 2.1 2.8 2 0 0 2 2 2 2 WW domain AAA_19 PF13245.1 KOO32094.1 - 0.00011 21.8 0.8 0.002 17.8 0.0 3.2 3 0 0 3 3 3 1 Part of AAA domain AAA_30 PF13604.1 KOO32094.1 - 0.00094 18.8 7.9 0.056 13.0 0.0 3.3 4 0 0 4 4 4 2 AAA domain DUF2075 PF09848.4 KOO32094.1 - 0.036 13.0 0.1 0.13 11.1 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) zf-RING_3 PF14369.1 KOO32094.1 - 0.1 12.6 1.5 0.29 11.1 1.1 1.7 1 0 0 1 1 1 0 zinc-finger AAA_22 PF13401.1 KOO32094.1 - 0.1 12.7 0.6 1.2 9.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 KOO32094.1 - 0.25 11.5 0.0 0.68 10.1 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) zf-C2H2 PF00096.21 KOO32097.1 - 1.2 9.5 4.6 0.32 11.4 0.1 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type Tic22 PF04278.7 KOO32098.1 - 0.0001 21.6 0.0 0.00061 19.1 0.0 2.1 1 1 0 1 1 1 1 Tic22-like family NDK PF00334.14 KOO32100.1 - 4.1e-05 23.3 0.0 0.0014 18.3 0.0 2.4 2 0 0 2 2 2 2 Nucleoside diphosphate kinase Hydrolase_6 PF13344.1 KOO32101.1 - 9e-30 102.5 0.0 1.4e-29 101.9 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOO32101.1 - 6.9e-17 60.9 0.0 2.8e-16 58.9 0.0 2.1 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.21 KOO32101.1 - 7.5e-10 39.5 0.1 1.9e-08 34.9 0.1 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 KOO32101.1 - 1.1e-08 35.5 0.1 0.01 16.0 0.0 2.8 2 1 1 3 3 3 2 Haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.5 KOO32101.1 - 0.0083 15.5 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Acid_phosphat_B PF03767.9 KOO32101.1 - 0.13 11.6 0.1 0.28 10.5 0.1 1.5 1 1 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) OTU PF02338.14 KOO32103.1 - 2.8e-17 63.4 0.1 7e-17 62.1 0.0 1.6 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 KOO32103.1 - 0.0041 16.4 0.1 0.69 9.2 0.0 2.1 1 1 1 2 2 2 2 Peptidase C65 Otubain B PF02216.11 KOO32103.1 - 0.13 12.0 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 B domain SAP PF02037.22 KOO32104.1 - 0.085 12.3 0.1 2 8.0 0.1 2.5 2 0 0 2 2 2 0 SAP domain FKBP_C PF00254.23 KOO32105.1 - 5.1e-18 64.8 0.0 9.3e-18 64.0 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Ribosomal_L6e PF01159.14 KOO32106.1 - 3.8e-36 123.6 0.0 5e-36 123.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L6e Choline_transpo PF04515.7 KOO32107.1 - 4.1e-70 236.1 25.6 4.1e-70 236.1 17.7 1.9 2 0 0 2 2 2 1 Plasma-membrane choline transporter DUF563 PF04577.9 KOO32108.1 - 0.00043 20.2 0.0 0.00062 19.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) TPR_1 PF00515.23 KOO32109.1 - 0.00025 20.5 0.2 1.1 9.0 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat Apolipoprotein PF01442.13 KOO32110.1 - 0.31 10.5 9.6 0.61 9.5 0.6 3.1 2 2 1 3 3 3 0 Apolipoprotein A1/A4/E domain Mga PF05043.8 KOO32111.1 - 0.099 12.9 0.4 18 5.7 0.0 2.6 2 0 0 2 2 2 0 Mga helix-turn-helix domain Lectin_N PF03954.9 KOO32111.1 - 0.59 9.5 11.6 2.1 7.7 1.1 3.3 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain Med9 PF07544.8 KOO32111.1 - 0.93 9.2 19.9 0.046 13.4 0.6 5.8 4 1 2 6 6 6 0 RNA polymerase II transcription mediator complex subunit 9 AAA PF00004.24 KOO32113.1 - 3.6e-06 27.2 0.0 8.6e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 KOO32113.1 - 0.017 14.8 0.1 0.7 9.6 0.0 2.6 2 0 0 2 2 2 0 Part of AAA domain RuvB_N PF05496.7 KOO32113.1 - 0.053 12.5 0.0 0.11 11.5 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KOO32113.1 - 0.075 13.1 0.7 1.8 8.6 0.5 2.4 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.1 KOO32113.1 - 0.084 12.4 0.3 2.3 7.7 0.2 2.2 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.1 KOO32113.1 - 0.15 12.8 0.1 0.54 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain Torsin PF06309.6 KOO32113.1 - 0.16 11.8 0.0 0.38 10.6 0.0 1.6 1 0 0 1 1 1 0 Torsin IstB_IS21 PF01695.12 KOO32113.1 - 0.16 11.3 0.0 0.39 10.1 0.0 1.6 2 0 0 2 2 2 0 IstB-like ATP binding protein PBP_like_2 PF12849.2 KOO32116.1 - 2.3e-48 165.1 1.8 2.6e-48 164.8 0.8 1.4 1 1 0 1 1 1 1 PBP superfamily domain Beta_helix PF13229.1 KOO32117.1 - 7.4e-12 45.2 16.2 2.1e-11 43.8 11.2 1.7 1 0 0 1 1 1 1 Right handed beta helix region NosD PF05048.8 KOO32117.1 - 1.8e-05 24.0 5.2 3.4e-05 23.0 3.6 1.4 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) SNF2_N PF00176.18 KOO32118.1 - 9.9e-22 77.0 0.0 1.4e-21 76.5 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain Gly-zipper_YMGG PF13441.1 KOO32118.1 - 0.0061 16.0 19.6 0.0061 16.0 13.6 3.3 2 1 1 3 3 3 2 YMGG-like Gly-zipper Gly-zipper_OmpA PF13436.1 KOO32118.1 - 0.041 13.5 30.6 0.17 11.5 13.1 2.6 1 1 1 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain Gly-zipper_Omp PF13488.1 KOO32118.1 - 6.8 6.4 48.4 0.063 12.9 12.8 3.0 2 1 1 3 3 3 0 Glycine zipper Helicase_C PF00271.26 KOO32119.1 - 0.02 14.7 0.0 0.047 13.5 0.0 1.6 2 0 0 2 2 2 0 Helicase conserved C-terminal domain Rick_17kDa_Anti PF05433.10 KOO32119.1 - 0.068 12.8 8.3 0.19 11.4 5.8 1.8 1 1 0 1 1 1 0 Glycine zipper 2TM domain DUF3734 PF12536.3 KOO32119.1 - 1.8 8.7 6.7 36 4.5 0.0 3.1 3 0 0 3 3 3 0 Patatin phospholipase Pkinase PF00069.20 KOO32120.1 - 4.8e-22 78.3 0.0 6.9e-22 77.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32120.1 - 6.7e-20 71.2 0.0 2.3e-19 69.4 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase MtrF PF09472.5 KOO32120.1 - 0.033 13.4 5.1 0.079 12.2 3.5 1.7 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Amnionless PF14828.1 KOO32120.1 - 0.079 11.4 0.0 0.09 11.2 0.0 1.1 1 0 0 1 1 1 0 Amnionless O-antigen_lig PF13425.1 KOO32120.1 - 0.088 12.7 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein RIO1 PF01163.17 KOO32120.1 - 0.17 11.2 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Adeno_E3_CR2 PF02439.10 KOO32120.1 - 0.19 11.2 7.2 0.37 10.3 5.0 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Rifin_STEVOR PF02009.11 KOO32120.1 - 1 8.9 7.8 0.18 11.4 2.9 1.4 2 0 0 2 2 2 0 Rifin/stevor family His_Phos_1 PF00300.17 KOO32121.1 - 2.3e-71 238.9 0.1 1.3e-38 132.5 0.0 2.4 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) WD40 PF00400.27 KOO32122.1 - 3.8e-27 93.1 14.6 6.9e-06 25.7 0.1 5.4 5 0 0 5 5 5 5 WD domain, G-beta repeat Apc4_WD40 PF12894.2 KOO32122.1 - 0.04 13.4 0.0 0.18 11.3 0.0 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Topoisom_bac PF01131.15 KOO32124.1 - 0.00028 19.8 0.0 0.00036 19.4 0.0 1.2 1 0 0 1 1 1 1 DNA topoisomerase Rotamase PF00639.16 KOO32125.1 - 2.2e-14 53.9 0.0 2.4e-14 53.8 0.0 1.0 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 KOO32125.1 - 4.2e-13 49.5 0.0 4.5e-13 49.4 0.0 1.0 1 0 0 1 1 1 1 PPIC-type PPIASE domain Lactonase PF10282.4 KOO32127.1 - 1.2e-57 195.6 0.0 2.3e-55 188.0 0.0 2.3 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Cytotoxic PF09000.5 KOO32127.1 - 0.051 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Cytotoxic 2-oxoacid_dh PF00198.18 KOO32130.1 - 1.8e-76 256.4 0.2 2.3e-76 256.1 0.1 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 KOO32130.1 - 4.7e-16 58.1 1.3 1e-15 57.0 0.9 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.12 KOO32130.1 - 3.5e-07 29.7 0.2 8.6e-07 28.4 0.1 1.7 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.1 KOO32130.1 - 0.035 13.7 0.2 0.084 12.5 0.2 1.6 1 0 0 1 1 1 0 Biotin-lipoyl like HALZ PF02183.13 KOO32131.1 - 0.12 12.1 2.6 0.38 10.5 0.0 3.1 3 1 0 3 3 3 0 Homeobox associated leucine zipper Bacteriocin_IIc PF10439.4 KOO32131.1 - 0.33 11.1 5.0 0.61 10.2 3.4 1.4 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Med24_N PF11277.3 KOO32131.1 - 0.87 7.0 9.1 0.065 10.7 1.1 1.9 1 1 1 2 2 2 0 Mediator complex subunit 24 N-terminal DUF16 PF01519.11 KOO32131.1 - 1.5 9.0 5.3 0.79 9.9 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF16 zf-C4H2 PF10146.4 KOO32131.1 - 2.9 7.8 12.7 0.16 12.0 3.4 2.4 1 1 1 2 2 2 0 Zinc finger-containing protein ThiS PF02597.15 KOO32131.1 - 4.1 7.9 6.6 1 9.8 0.6 2.8 1 1 0 2 2 2 0 ThiS family NUMOD3 PF07460.6 KOO32133.1 - 5e-08 32.6 7.1 6e-05 22.8 0.1 4.8 3 2 1 4 4 4 4 NUMOD3 motif (2 copies) HSP70 PF00012.15 KOO32134.1 - 2.4e-21 75.3 0.1 3.5e-21 74.7 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein STOP PF05217.7 KOO32134.1 - 3.1e-08 33.6 17.7 7.4e-05 22.5 1.3 2.1 1 1 1 2 2 2 2 STOP protein RRM_1 PF00076.17 KOO32135.1 - 1.9e-31 107.4 0.0 1.6e-12 46.8 0.0 3.8 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO32135.1 - 5.8e-23 80.5 0.1 1.8e-07 30.8 0.0 3.7 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO32135.1 - 6e-18 64.5 0.1 4.9e-07 29.6 0.0 4.4 4 1 0 4 4 4 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) WW PF00397.21 KOO32135.1 - 1.6e-08 34.2 1.7 3.1e-08 33.3 1.2 1.5 1 0 0 1 1 1 1 WW domain Nup35_RRM_2 PF14605.1 KOO32135.1 - 2.2e-06 27.3 0.0 0.0079 15.9 0.0 2.9 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 KOO32135.1 - 8.6e-06 25.5 0.0 0.016 15.0 0.0 3.1 3 1 0 3 3 3 2 RNA binding motif RNA_bind PF08675.6 KOO32135.1 - 0.00057 19.8 0.0 0.058 13.3 0.0 2.7 3 0 0 3 3 3 1 RNA binding domain DUF4651 PF15513.1 KOO32135.1 - 0.029 13.8 0.2 3 7.3 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4651) PCI PF01399.22 KOO32136.1 - 7.6e-07 29.4 2.5 2.8e-05 24.3 0.1 3.4 3 0 0 3 3 3 1 PCI domain SDH_beta PF03315.10 KOO32136.1 - 0.36 10.8 2.9 1.1 9.3 1.6 2.2 1 1 0 1 1 1 0 Serine dehydratase beta chain HATPase_c PF02518.21 KOO32137.1 - 0.0013 18.4 0.0 0.0056 16.3 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 KOO32137.1 - 0.025 14.2 0.1 0.64 9.6 0.1 2.3 1 1 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 PF00183.13 KOO32137.1 - 0.82 7.9 10.4 2.6 6.3 7.2 1.7 1 1 0 1 1 1 0 Hsp90 protein EF-hand_1 PF00036.27 KOO32138.1 - 2.4e-05 23.3 0.1 4.9e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO32138.1 - 0.0003 20.4 0.1 0.00075 19.1 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 KOO32138.1 - 0.00051 20.1 0.0 0.0012 18.9 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO32138.1 - 0.0047 16.2 0.0 0.013 14.8 0.0 1.7 1 0 0 1 1 1 1 EF hand Glyco_transf_34 PF05637.7 KOO32138.1 - 0.072 12.5 0.0 0.74 9.2 0.0 2.4 3 0 0 3 3 3 0 galactosyl transferase GMA12/MNN10 family TPR_12 PF13424.1 KOO32140.1 - 0.00019 21.3 5.8 0.00019 21.3 4.0 2.8 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.1 KOO32140.1 - 0.013 15.4 5.7 0.013 15.4 3.9 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat SHIPPO-rpt PF07004.7 KOO32141.1 - 4.1e-07 30.5 45.4 0.011 16.6 0.4 10.9 12 0 0 12 12 12 7 Sperm-tail PG-rich repeat DUF2246 PF10229.4 KOO32142.1 - 0.0007 18.9 0.0 0.0029 16.9 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2246) RskA PF10099.4 KOO32142.1 - 0.28 10.8 3.3 0.46 10.2 2.3 1.4 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Roughex PF06020.6 KOO32143.1 - 0.022 13.4 0.4 0.024 13.2 0.3 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Mito_fiss_reg PF05308.6 KOO32145.1 - 0.018 14.4 0.5 0.018 14.4 0.3 1.3 1 1 0 1 1 1 0 Mitochondrial fission regulator Mto2_bdg PF12808.2 KOO32145.1 - 0.15 12.1 0.3 0.28 11.3 0.2 1.5 1 1 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region PIP5K PF01504.13 KOO32146.1 - 2.9e-43 147.8 0.0 4.1e-43 147.3 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF3959 PF13105.1 KOO32146.1 - 0.089 12.1 0.5 0.14 11.4 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) DUF4440 PF14534.1 KOO32147.1 - 0.086 13.0 0.1 0.19 11.9 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Phage_T7_Capsid PF05396.6 KOO32147.1 - 0.1 12.7 1.6 0.18 11.9 0.7 1.7 1 1 0 1 1 1 0 Phage T7 capsid assembly protein Seryl_tRNA_N PF02403.17 KOO32147.1 - 0.11 12.4 12.3 0.073 13.0 2.1 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain EF-hand_6 PF13405.1 KOO32148.1 - 2.8e-55 179.2 21.8 1.6e-07 30.6 0.1 13.2 13 0 0 13 13 13 9 EF-hand domain EF-hand_1 PF00036.27 KOO32148.1 - 4.1e-54 175.8 18.4 1.7e-07 30.0 0.1 13.1 13 0 0 13 13 13 7 EF hand EF-hand_7 PF13499.1 KOO32148.1 - 7e-45 151.0 12.0 5.7e-07 29.5 0.0 10.7 4 3 5 9 9 9 8 EF-hand domain pair EF-hand_5 PF13202.1 KOO32148.1 - 5.7e-27 91.8 46.7 2e-06 26.8 0.0 10.2 12 0 0 12 12 12 6 EF hand EF-hand_8 PF13833.1 KOO32148.1 - 5.5e-22 77.1 36.4 1.6e-05 24.4 0.0 10.9 9 5 4 13 13 13 9 EF-hand domain pair EF-hand_10 PF14788.1 KOO32148.1 - 0.00014 21.4 9.1 3 7.5 0.0 6.9 7 1 0 7 7 7 1 EF hand DUF615 PF04751.9 KOO32148.1 - 0.0017 18.0 8.8 0.078 12.6 0.1 4.4 5 0 0 5 5 5 1 Protein of unknown function (DUF615) EF-hand_4 PF12763.2 KOO32148.1 - 0.0067 16.1 21.0 3.8 7.3 0.0 7.5 6 2 2 8 8 8 1 Cytoskeletal-regulatory complex EF hand Sigma70_r1_1 PF03979.9 KOO32148.1 - 0.0067 16.3 0.0 65 3.5 0.0 5.1 5 0 0 5 5 5 0 Sigma-70 factor, region 1.1 Imm3 PF14425.1 KOO32148.1 - 0.071 13.0 8.4 8.9 6.3 0.0 4.8 6 0 0 6 6 6 0 Immunity protein Imm3 Cbl_N3 PF02762.9 KOO32148.1 - 0.2 11.2 0.0 1.1e+02 2.4 0.0 4.1 5 0 0 5 5 5 0 CBL proto-oncogene N-terminus, SH2-like domain Peptidase_M3_N PF08439.5 KOO32148.1 - 0.26 11.3 6.6 0.89 9.6 0.1 4.8 5 0 0 5 5 5 0 Oligopeptidase F Vps5 PF09325.5 KOO32148.1 - 0.48 9.6 15.5 0.15 11.3 0.1 4.5 5 0 0 5 5 5 0 Vps5 C terminal like YueH PF14166.1 KOO32148.1 - 4.8 7.0 9.9 47 3.8 0.0 5.0 5 0 0 5 5 5 0 YueH-like protein EF-hand_1 PF00036.27 KOO32149.1 - 7.5e-31 103.0 12.7 1.4e-06 27.1 0.6 7.5 7 0 0 7 7 7 7 EF hand EF-hand_6 PF13405.1 KOO32149.1 - 1.2e-30 102.6 6.0 6.3e-06 25.6 0.1 7.5 7 0 0 7 7 7 7 EF-hand domain EF-hand_7 PF13499.1 KOO32149.1 - 7.3e-23 80.4 10.9 1e-07 31.9 0.3 6.4 4 2 1 6 6 6 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO32149.1 - 4e-14 51.2 22.4 0.00018 20.6 0.4 5.5 6 0 0 6 6 6 4 EF hand EF-hand_8 PF13833.1 KOO32149.1 - 1.7e-12 46.7 20.5 0.00027 20.5 0.4 6.2 4 3 2 6 6 6 5 EF-hand domain pair EF-hand_4 PF12763.2 KOO32149.1 - 0.00045 19.9 12.0 0.78 9.5 0.0 5.3 3 3 3 6 6 6 2 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO32149.1 - 0.28 10.8 6.9 20 4.9 0.1 4.8 5 1 1 6 6 6 0 EF hand Ank_2 PF12796.2 KOO32152.1 - 9.6e-22 77.1 0.3 5.5e-11 42.6 0.0 1.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO32152.1 - 2.3e-08 33.4 0.1 0.00091 18.9 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 KOO32152.1 - 3.4e-06 26.7 0.1 0.24 11.7 0.0 3.3 2 1 1 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOO32152.1 - 8e-06 26.2 0.0 1.9e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO32152.1 - 1.1e-05 25.4 0.1 0.00023 21.3 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) DUF2784 PF10861.3 KOO32153.1 - 0.35 10.6 4.7 0.13 12.0 1.2 1.7 1 1 0 2 2 2 0 Protein of Unknown function (DUF2784) Pkinase PF00069.20 KOO32154.1 - 2.5e-49 167.7 0.0 4.1e-34 117.9 0.0 3.0 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32154.1 - 2.9e-23 82.2 0.0 1.4e-19 70.2 0.0 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.1 KOO32154.1 - 7e-07 28.4 0.0 0.0012 17.8 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.9 KOO32154.1 - 0.0007 18.7 0.1 0.0069 15.4 0.0 2.0 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO32154.1 - 0.042 13.5 0.4 0.042 13.5 0.3 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family RIO1 PF01163.17 KOO32154.1 - 0.049 12.9 0.0 0.075 12.3 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Pox_ser-thr_kin PF05445.6 KOO32154.1 - 0.38 9.5 0.0 0.53 9.0 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Neisseria_TspB PF05616.8 KOO32154.1 - 0.45 8.8 1.6 0.67 8.2 1.1 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein RRM_1 PF00076.17 KOO32155.1 - 3.8e-50 167.3 0.0 6.2e-14 51.3 0.0 4.2 3 1 1 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO32155.1 - 3.5e-43 145.4 0.0 6.4e-13 48.4 0.0 4.3 3 1 1 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO32155.1 - 7.4e-27 92.9 0.0 3.1e-11 42.9 0.0 3.5 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 KOO32155.1 - 0.14 11.9 0.2 23 4.8 0.0 2.7 3 0 0 3 3 3 0 Limkain b1 Saccharop_dh PF03435.13 KOO32156.1 - 1.5e-18 66.9 0.6 2e-18 66.5 0.4 1.1 1 0 0 1 1 1 1 Saccharopine dehydrogenase PTPLA PF04387.9 KOO32156.1 - 9.7e-11 41.3 0.9 1.6e-10 40.6 0.6 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA EF-hand_1 PF00036.27 KOO32158.1 - 1.2e-18 64.9 0.7 9.3e-09 33.9 0.3 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO32158.1 - 2.5e-15 55.8 1.6 2.5e-14 52.6 0.2 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.1 KOO32158.1 - 3.7e-14 52.6 0.1 5.6e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO32158.1 - 1.3e-13 49.5 0.1 4.6e-06 26.0 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO32158.1 - 1.3e-10 40.1 2.9 6.2e-05 22.1 0.0 2.6 2 1 0 2 2 2 2 EF hand EF-hand_9 PF14658.1 KOO32158.1 - 1e-06 28.5 0.0 1.6e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.2 KOO32158.1 - 0.00013 21.6 0.0 0.00022 20.9 0.0 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO32158.1 - 0.02 14.9 0.0 0.033 14.2 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Pyridoxal_deC PF00282.14 KOO32159.1 - 3.1e-17 62.1 0.0 4.7e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.14 KOO32159.1 - 8.4e-08 31.3 0.0 2.4e-07 29.8 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 KOO32159.1 - 0.07 12.2 0.1 0.16 11.0 0.1 1.5 1 0 0 1 1 1 0 Beta-eliminating lyase Acetyltransf_1 PF00583.19 KOO32163.1 - 1.5e-11 44.1 0.0 6.6e-11 42.0 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 KOO32163.1 - 1.1e-06 28.7 0.0 4.2e-06 26.8 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 KOO32163.1 - 5.6e-06 26.4 0.1 8.8e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 KOO32163.1 - 0.0001 21.9 0.0 0.00034 20.3 0.0 1.9 1 1 1 2 2 2 1 FR47-like protein Acetyltransf_CG PF14542.1 KOO32163.1 - 0.027 14.3 0.0 0.065 13.1 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_8 PF13523.1 KOO32163.1 - 0.035 13.9 0.0 0.054 13.3 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 KOO32163.1 - 0.078 13.1 0.0 1.5 8.9 0.0 2.3 1 1 0 2 2 2 0 Acetyltransferase (GNAT) domain DnaJ PF00226.26 KOO32164.1 - 0.0002 20.9 0.0 0.00062 19.4 0.0 1.9 1 0 0 1 1 1 1 DnaJ domain HhH-GPD PF00730.20 KOO32165.1 - 2.1e-16 60.1 0.0 3.3e-16 59.4 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 KOO32165.1 - 9.4e-07 28.1 0.4 2.2e-06 27.0 0.0 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.1 KOO32165.1 - 0.074 13.2 0.0 0.22 11.6 0.0 1.8 1 1 0 1 1 1 0 Helix-hairpin-helix domain zf-C2H2 PF00096.21 KOO32166.1 - 0.014 15.7 4.6 0.74 10.2 0.0 4.0 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOO32166.1 - 0.071 13.4 11.9 9.6 6.7 3.0 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger Metallophos PF00149.23 KOO32167.1 - 4.3e-17 62.1 0.0 7e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase EF-hand_1 PF00036.27 KOO32167.1 - 1.3e-12 46.0 0.2 5.9e-05 22.0 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO32167.1 - 6.9e-11 42.1 0.2 1.8e-10 40.8 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO32167.1 - 7.5e-11 40.9 0.1 0.00037 20.1 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO32167.1 - 2.9e-10 39.6 0.1 0.0005 19.6 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO32167.1 - 1.1e-09 37.1 0.9 0.00046 19.4 0.0 2.6 2 0 0 2 2 2 2 EF hand Fes1 PF08609.5 KOO32167.1 - 0.27 11.7 5.4 0.91 10.0 0.9 3.1 4 0 0 4 4 4 0 Nucleotide exchange factor Fes1 Cytochrom_B562 PF07361.6 KOO32167.1 - 0.31 11.4 1.1 0.48 10.8 0.0 1.8 2 0 0 2 2 2 0 Cytochrome b562 tRNA-synt_1c PF00749.16 KOO32168.1 - 5.3e-91 304.5 0.0 8e-91 303.9 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 KOO32168.1 - 3.2e-28 98.5 0.0 3e-26 92.1 0.0 2.4 1 1 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain EI24 PF07264.6 KOO32169.1 - 0.00029 20.3 0.0 0.0081 15.6 0.0 2.1 2 0 0 2 2 2 1 Etoposide-induced protein 2.4 (EI24) Peptidase_M10 PF00413.19 KOO32169.1 - 0.0016 18.2 0.0 0.004 16.8 0.0 1.7 2 0 0 2 2 2 1 Matrixin Metallopep PF12044.3 KOO32169.1 - 0.13 10.6 0.8 0.21 9.9 0.5 1.2 1 0 0 1 1 1 0 Putative peptidase family Ceramidase PF05875.7 KOO32169.1 - 0.31 10.1 2.6 0.29 10.2 0.8 1.7 2 0 0 2 2 2 0 Ceramidase MIP-T3 PF10243.4 KOO32171.1 - 0.00021 19.8 27.5 0.00024 19.6 19.1 1.1 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 LMBR1 PF04791.11 KOO32171.1 - 0.15 10.6 3.4 0.22 10.0 2.3 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein VIT1 PF01988.14 KOO32171.1 - 0.17 11.3 4.4 0.54 9.7 3.0 1.9 1 1 0 1 1 1 0 VIT family Pkinase PF00069.20 KOO32172.1 - 1.3e-33 116.2 0.0 1.4e-31 109.6 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32172.1 - 9.6e-12 44.5 0.0 2.3e-10 39.9 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO32172.1 - 0.0052 15.7 0.0 0.023 13.6 0.0 1.9 1 1 0 1 1 1 1 Kinase-like DUF936 PF06075.7 KOO32172.1 - 0.15 10.9 6.9 0.95 8.3 0.2 2.3 2 0 0 2 2 2 0 Plant protein of unknown function (DUF936) PIF1 PF05970.9 KOO32173.1 - 4.3e-55 187.1 0.5 7.9e-45 153.3 0.0 2.6 2 1 1 3 3 3 2 PIF1-like helicase AAA_30 PF13604.1 KOO32173.1 - 7e-13 48.5 0.4 2.6e-10 40.2 0.1 3.1 3 0 0 3 3 3 1 AAA domain TPR_11 PF13414.1 KOO32173.1 - 1.1e-06 28.1 0.2 1.1e-06 28.1 0.1 4.2 4 0 0 4 4 4 2 TPR repeat HRDC PF00570.18 KOO32173.1 - 2.4e-06 27.1 0.0 6.6e-06 25.7 0.0 1.9 1 0 0 1 1 1 1 HRDC domain AAA_19 PF13245.1 KOO32173.1 - 5.3e-06 26.1 0.7 5.3e-06 26.1 0.5 2.9 3 0 0 3 3 2 1 Part of AAA domain AAA_22 PF13401.1 KOO32173.1 - 6.4e-06 26.3 0.0 2.7e-05 24.3 0.0 2.0 1 0 0 1 1 1 1 AAA domain PhoH PF02562.11 KOO32173.1 - 0.0034 16.6 0.0 0.01 15.0 0.0 1.8 2 0 0 2 2 2 1 PhoH-like protein UvrD_C_2 PF13538.1 KOO32173.1 - 0.0081 16.2 0.0 0.021 14.9 0.0 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_5 PF07728.9 KOO32173.1 - 0.014 15.0 0.0 0.4 10.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) T2SE PF00437.15 KOO32173.1 - 0.019 13.8 0.0 0.036 12.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein UvrD-helicase PF00580.16 KOO32173.1 - 0.062 12.5 0.1 0.12 11.6 0.1 1.4 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_29 PF13555.1 KOO32173.1 - 0.09 12.3 0.1 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Viral_helicase1 PF01443.13 KOO32173.1 - 0.17 11.3 0.3 3.6 7.0 0.0 2.6 2 1 0 2 2 2 0 Viral (Superfamily 1) RNA helicase TPR_1 PF00515.23 KOO32173.1 - 0.21 11.2 5.5 4.1 7.1 0.1 3.8 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO32173.1 - 0.53 10.2 14.0 0.8 9.6 1.3 4.2 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO32173.1 - 2.2 8.9 10.8 1.7 9.2 0.1 4.7 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 KOO32173.1 - 6.3 7.6 32.7 7.2 7.4 1.4 5.8 5 0 0 5 5 4 0 Tetratricopeptide repeat RRM_1 PF00076.17 KOO32174.1 - 0.013 15.0 0.0 0.032 13.8 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO32174.1 - 0.07 12.9 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DAP3 PF10236.4 KOO32174.1 - 0.2 10.5 0.1 0.98 8.2 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 CinA PF02464.12 KOO32175.1 - 0.027 13.9 0.3 0.035 13.5 0.2 1.2 1 0 0 1 1 1 0 Competence-damaged protein VCBS PF13517.1 KOO32177.1 - 1.5e-157 512.1 184.0 2e-14 53.6 3.2 18.5 5 4 13 18 18 18 18 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO32177.1 - 3.8e-100 325.6 180.8 5.9e-06 25.8 0.4 20.5 20 0 0 20 20 20 20 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO32177.1 - 4.3e-31 107.7 76.4 0.18 11.2 0.1 20.1 5 3 15 20 20 20 18 Insecticide toxin TcdB middle/N-terminal region GCC2_GCC3 PF07699.8 KOO32177.1 - 2.1e-08 33.5 81.1 0.0012 18.3 1.2 10.9 2 1 8 10 10 10 6 GCC2 and GCC3 NCD3G PF07562.9 KOO32177.1 - 1.4e-06 27.9 44.2 0.0034 17.0 2.0 6.9 5 1 3 8 8 8 3 Nine Cysteines Domain of family 3 GPCR Arrestin_N PF00339.24 KOO32177.1 - 0.013 15.3 0.1 2.8e+02 1.2 0.0 7.2 11 0 0 11 11 11 0 Arrestin (or S-antigen), N-terminal domain Glyco_transf_56 PF07429.6 KOO32177.1 - 1.1 8.1 0.2 1.3e+02 1.3 0.0 3.9 4 0 0 4 4 4 0 4-alpha-L-fucosyltransferase glycosyl transferase group 56 Abi PF02517.11 KOO32178.1 - 7e-17 61.3 5.8 7e-17 61.3 4.0 2.4 2 1 0 2 2 2 1 CAAX protease self-immunity zf-Nse PF11789.3 KOO32179.1 - 8.4e-06 25.2 0.1 1.6e-05 24.3 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 KOO32179.1 - 9.2e-06 25.2 0.1 2.6e-05 23.8 0.1 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.1 KOO32179.1 - 0.019 14.7 0.2 0.086 12.6 0.1 2.1 1 1 1 2 2 2 0 Ring finger domain Rtf2 PF04641.7 KOO32179.1 - 0.031 13.4 0.7 0.031 13.4 0.5 2.0 1 1 0 2 2 2 0 Rtf2 RING-finger BCDHK_Adom3 PF10436.4 KOO32179.1 - 0.033 13.7 0.2 0.053 13.0 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase zf-C3HC4_2 PF13923.1 KOO32179.1 - 0.15 12.1 0.8 0.36 10.8 0.3 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Lebercilin PF15619.1 KOO32180.1 - 0.0008 18.8 9.9 0.0008 18.8 6.9 4.2 1 1 3 4 4 4 1 Ciliary protein causing Leber congenital amaurosis disease DUF3972 PF13118.1 KOO32180.1 - 0.27 11.3 0.2 0.27 11.3 0.1 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3972) GAS PF13851.1 KOO32180.1 - 0.52 9.4 40.6 0.64 9.1 6.1 3.5 2 1 0 3 3 3 0 Growth-arrest specific micro-tubule binding IQ PF00612.22 KOO32181.1 - 2.4e-08 32.8 60.4 0.17 11.6 0.1 9.5 8 0 0 8 8 8 8 IQ calmodulin-binding motif RNA_pol_Rpb4 PF03874.11 KOO32182.1 - 2.2e-16 59.9 0.1 2.6e-16 59.6 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 DUF2450 PF10475.4 KOO32182.1 - 0.059 12.2 0.1 0.097 11.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function N-terminal domain (DUF2450) Androgen_recep PF02166.11 KOO32182.1 - 0.31 9.8 4.0 0.65 8.8 0.1 2.0 1 1 1 2 2 2 0 Androgen receptor SET PF00856.23 KOO32183.1 - 8.4e-20 71.6 0.1 1.1e-18 68.1 0.1 2.3 1 1 0 1 1 1 1 SET domain Cys_Met_Meta_PP PF01053.15 KOO32184.1 - 2.3e-137 457.4 0.0 2.6e-137 457.2 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 KOO32184.1 - 4.4e-07 28.9 0.1 1.7e-06 27.0 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 KOO32184.1 - 2.6e-06 26.7 0.5 4e-06 26.1 0.4 1.4 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family GDC-P PF02347.11 KOO32184.1 - 0.066 11.8 0.3 0.089 11.4 0.2 1.2 1 0 0 1 1 1 0 Glycine cleavage system P-protein Beta_elim_lyase PF01212.16 KOO32184.1 - 0.067 12.3 0.1 0.17 11.0 0.0 1.7 2 0 0 2 2 2 0 Beta-eliminating lyase Pkinase PF00069.20 KOO32185.1 - 6.9e-43 146.6 0.0 8.8e-43 146.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32185.1 - 6.6e-19 67.9 0.0 9.5e-19 67.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Myosin_head PF00063.16 KOO32188.1 - 2.3e-130 435.7 0.0 3.7e-130 435.1 0.0 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_12 PF13087.1 KOO32190.1 - 3.4e-43 147.3 0.0 4.7e-43 146.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.1 KOO32190.1 - 5.8e-06 26.3 0.3 1.6e-05 24.9 0.1 1.9 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain PARP PF00644.15 KOO32191.1 - 8.7e-14 51.4 0.1 2.1e-13 50.1 0.0 1.7 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain HP_OMP PF01856.12 KOO32191.1 - 0.073 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Helicobacter outer membrane protein DUF572 PF04502.8 KOO32191.1 - 0.54 9.4 18.0 1.1 8.4 12.5 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF1675 PF07897.6 KOO32191.1 - 4.9 6.9 7.6 8.7 6.1 5.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) SNF5 PF04855.7 KOO32193.1 - 0.00053 19.5 0.1 0.002 17.6 0.0 2.0 1 1 1 2 2 2 1 SNF5 / SMARCB1 / INI1 DUF1702 PF08012.6 KOO32194.1 - 0.21 10.1 2.5 0.36 9.3 1.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1702) Chloroa_b-bind PF00504.16 KOO32196.1 - 1.1e-23 84.1 0.1 6.2e-23 81.7 0.0 2.1 2 1 0 2 2 2 1 Chlorophyll A-B binding protein ADIP PF11559.3 KOO32197.1 - 0.0089 15.9 16.9 0.0089 15.9 11.7 7.7 3 2 4 8 8 8 4 Afadin- and alpha -actinin-Binding U-box PF04564.10 KOO32197.1 - 0.036 14.0 0.0 0.13 12.2 0.0 1.9 1 0 0 1 1 1 0 U-box domain Reo_sigmaC PF04582.7 KOO32197.1 - 2.6 7.1 21.3 1.8 7.6 0.9 4.9 2 2 5 7 7 7 0 Reovirus sigma C capsid protein Myb_DNA-binding PF00249.26 KOO32198.1 - 2.1e-26 91.7 0.4 4.6e-12 45.8 0.0 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO32198.1 - 1.9e-20 72.7 0.2 8.3e-12 45.0 0.0 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 KOO32198.1 - 0.14 12.3 2.2 1.2 9.3 0.0 2.5 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain Trypsin_2 PF13365.1 KOO32199.1 - 2.1e-15 56.7 0.5 3.6e-15 55.9 0.4 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain ClpS PF02617.12 KOO32199.1 - 4.1e-07 29.6 0.0 8.5e-07 28.6 0.0 1.5 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS Trypsin PF00089.21 KOO32199.1 - 9.2e-05 22.1 0.0 0.00022 20.9 0.0 1.6 1 1 0 1 1 1 1 Trypsin Peptidase_S32 PF05579.8 KOO32199.1 - 2.7 6.8 7.6 1.9 7.4 2.6 2.3 2 1 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 Myb_DNA-binding PF00249.26 KOO32200.1 - 1.1e-23 82.9 0.0 4.5e-11 42.6 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO32200.1 - 3.6e-23 81.4 0.0 1.5e-11 44.2 0.0 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_2 PF08914.6 KOO32200.1 - 0.0031 17.2 0.9 0.36 10.6 0.1 3.2 2 2 0 2 2 2 1 Rap1 Myb domain TRAPP PF04051.11 KOO32201.1 - 3.7e-35 120.6 0.1 4.3e-35 120.4 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Pkinase PF00069.20 KOO32202.1 - 4e-70 235.9 0.0 5.2e-70 235.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32202.1 - 4.6e-38 130.7 0.0 6.5e-38 130.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO32202.1 - 1.9e-06 27.0 0.4 3.6e-06 26.1 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Choline_kinase PF01633.15 KOO32202.1 - 1e-05 25.2 0.0 1.7e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.17 KOO32202.1 - 1.2e-05 24.7 0.5 2.3e-05 23.8 0.3 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 KOO32202.1 - 0.00026 20.1 0.5 0.00056 19.0 0.2 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO32202.1 - 0.00096 18.9 1.6 0.0043 16.8 0.1 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 KOO32202.1 - 0.0052 16.1 0.1 0.0092 15.3 0.1 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL FlxA PF14282.1 KOO32202.1 - 0.068 13.1 5.0 0.14 12.1 3.5 1.4 1 0 0 1 1 1 0 FlxA-like protein Rho_Binding PF08912.6 KOO32202.1 - 0.18 12.1 4.2 4.6 7.6 0.6 2.5 2 0 0 2 2 2 0 Rho Binding DUF3138 PF11336.3 KOO32202.1 - 0.53 8.4 2.5 0.82 7.7 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) SET PF00856.23 KOO32203.1 - 4.6e-07 30.2 0.0 1.6e-06 28.5 0.0 1.9 1 1 0 1 1 1 1 SET domain DLIC PF05783.6 KOO32203.1 - 0.36 9.4 1.4 0.62 8.6 1.0 1.4 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Chloroa_b-bind PF00504.16 KOO32204.1 - 2.7e-25 89.4 0.0 1.1e-24 87.4 0.0 1.8 1 1 0 1 1 1 1 Chlorophyll A-B binding protein WD40 PF00400.27 KOO32205.1 - 7.4e-65 212.6 23.7 1.4e-11 43.7 1.7 7.5 7 1 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 KOO32205.1 - 3.7e-05 23.5 0.2 0.039 13.6 0.0 3.4 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.7 KOO32205.1 - 0.0029 15.5 0.3 0.056 11.2 0.1 2.1 2 0 0 2 2 2 1 IKI3 family DUF4613 PF15390.1 KOO32205.1 - 0.011 14.0 0.3 0.015 13.5 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) Nucleoporin_N PF08801.6 KOO32205.1 - 0.12 11.1 0.0 0.33 9.6 0.0 1.7 1 0 0 1 1 1 0 Nup133 N terminal like Bacteriocin_IIc PF10439.4 KOO32206.1 - 0.19 11.8 1.3 0.39 10.8 0.0 2.2 1 1 1 2 2 2 0 Bacteriocin class II with double-glycine leader peptide ROK PF00480.15 KOO32207.1 - 2.2e-05 24.3 5.4 3.4e-05 23.7 3.7 1.3 1 0 0 1 1 1 1 ROK family SKI PF01202.17 KOO32207.1 - 0.093 12.5 0.0 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 Shikimate kinase Galactosyl_T PF01762.16 KOO32209.1 - 2.2e-05 24.1 0.0 5.4e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Galactosyltransferase Ldl_recept_b PF00058.12 KOO32209.1 - 0.00025 21.2 0.1 0.0048 17.1 0.0 3.0 3 0 0 3 3 3 1 Low-density lipoprotein receptor repeat class B Acylphosphatase PF00708.13 KOO32210.1 - 5e-09 36.1 0.0 0.00027 20.9 0.0 2.9 2 1 1 3 3 3 2 Acylphosphatase Sec23_helical PF04815.10 KOO32211.1 - 2.2e-12 46.3 0.0 3.7e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Gelsolin PF00626.17 KOO32211.1 - 3.9e-08 32.8 0.0 6e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 Gelsolin repeat Pkinase PF00069.20 KOO32212.1 - 1.7e-50 171.6 0.0 2.6e-50 171.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.24 KOO32212.1 - 1e-25 89.3 1.1 2.3e-12 46.5 0.0 2.9 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.12 KOO32212.1 - 1.2e-20 73.6 0.0 2.6e-20 72.6 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase RGS PF00615.14 KOO32212.1 - 4.7e-06 26.6 0.0 5e-05 23.3 0.0 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain Kinase-like PF14531.1 KOO32212.1 - 0.02 13.8 0.0 0.039 12.9 0.0 1.5 1 0 0 1 1 1 0 Kinase-like UQ_con PF00179.21 KOO32213.1 - 7.5e-54 180.9 0.0 8.6e-31 106.2 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KOO32213.1 - 1.8e-09 37.4 0.1 0.00031 20.4 0.0 3.2 3 0 0 3 3 3 2 Prokaryotic E2 family B RWD PF05773.17 KOO32213.1 - 2.1e-07 30.7 0.0 0.0069 16.2 0.0 2.4 2 0 0 2 2 2 2 RWD domain UEV PF05743.8 KOO32213.1 - 1.5e-05 24.6 0.1 0.00063 19.4 0.0 2.4 2 0 0 2 2 2 1 UEV domain Amidohydro_1 PF01979.15 KOO32214.1 - 7e-22 78.5 0.2 9.1e-22 78.1 0.1 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_2 PF04909.9 KOO32214.1 - 0.0052 16.3 0.1 0.0097 15.4 0.1 1.6 1 1 0 1 1 1 1 Amidohydrolase DnaJ PF00226.26 KOO32216.1 - 3e-07 30.0 0.7 2.3e-06 27.2 0.0 2.7 3 0 0 3 3 3 1 DnaJ domain z-alpha PF02295.12 KOO32216.1 - 0.1 12.3 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 Adenosine deaminase z-alpha domain Bestrophin PF01062.16 KOO32217.1 - 4e-50 170.4 1.2 5.4e-50 169.9 0.9 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel ACT_7 PF13840.1 KOO32217.1 - 0.06 12.8 0.1 0.13 11.8 0.1 1.5 1 0 0 1 1 1 0 ACT domain YWFCY PF14293.1 KOO32217.1 - 0.065 13.0 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 YWFCY protein COesterase PF00135.23 KOO32218.1 - 1.1e-85 288.3 0.0 1.5e-85 287.9 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.8 KOO32218.1 - 2.2e-09 37.1 5.1 0.00067 19.2 0.1 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 KOO32218.1 - 0.0005 19.8 0.3 0.0011 18.7 0.2 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 KOO32218.1 - 0.042 13.0 0.4 0.083 12.1 0.3 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family Methyltransf_26 PF13659.1 KOO32220.1 - 3.1e-11 43.3 0.3 3.1e-11 43.3 0.2 2.2 2 1 0 2 2 2 1 Methyltransferase domain UPF0020 PF01170.13 KOO32220.1 - 1.3e-08 34.6 0.0 0.00018 21.1 0.0 2.3 2 0 0 2 2 2 2 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.13 KOO32220.1 - 0.00051 19.6 0.0 0.014 14.8 0.0 2.1 2 0 0 2 2 2 1 DNA methylase Cons_hypoth95 PF03602.10 KOO32220.1 - 0.02 14.2 0.0 6.4 6.1 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical protein 95 DAO PF01266.19 KOO32221.1 - 3.3e-13 49.2 4.0 4.4e-13 48.8 2.7 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase MscS_porin PF12795.2 KOO32222.1 - 0.00071 18.9 2.5 0.0012 18.2 1.7 1.5 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain ERM PF00769.14 KOO32222.1 - 0.052 13.0 4.4 0.065 12.7 3.0 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family KLRAQ PF10205.4 KOO32222.1 - 0.078 13.0 0.9 6.5 6.8 0.5 2.5 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein PH PF00169.24 KOO32223.1 - 1.5e-06 28.3 0.0 2.5e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_8 PF15409.1 KOO32223.1 - 0.00018 21.4 0.2 0.00048 20.1 0.1 1.8 2 1 0 2 2 2 1 Pleckstrin homology domain Mcp5_PH PF12814.2 KOO32223.1 - 0.0084 16.0 0.0 0.018 14.9 0.0 1.6 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH_6 PF15406.1 KOO32223.1 - 0.049 13.6 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain PAP1 PF08601.5 KOO32223.1 - 0.73 9.4 4.9 0.11 12.1 0.3 1.9 2 0 0 2 2 2 0 Transcription factor PAP1 LMBR1 PF04791.11 KOO32225.1 - 3.4e-25 88.5 0.0 2e-16 59.6 0.2 2.1 2 0 0 2 2 2 2 LMBR1-like membrane protein LrgA PF03788.9 KOO32225.1 - 0.13 11.9 3.3 0.078 12.6 0.4 2.2 2 0 0 2 2 2 0 LrgA family DUF2207 PF09972.4 KOO32225.1 - 9.8 4.6 5.3 13 4.1 1.5 2.4 2 1 1 3 3 3 0 Predicted membrane protein (DUF2207) PPC PF04151.10 KOO32226.1 - 0.0042 18.0 0.0 0.011 16.6 0.0 1.7 1 0 0 1 1 1 1 Bacterial pre-peptidase C-terminal domain PSI_PsaE PF02427.12 KOO32227.1 - 1.5e-31 107.5 0.2 1.9e-31 107.2 0.2 1.1 1 0 0 1 1 1 1 Photosystem I reaction centre subunit IV / PsaE EF-hand_7 PF13499.1 KOO32228.1 - 1e-13 51.1 3.1 2e-09 37.4 1.6 3.3 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO32228.1 - 3.5e-13 47.8 6.4 0.00038 19.5 0.1 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 KOO32228.1 - 2.2e-12 45.7 4.4 0.00087 18.9 0.1 4.3 4 1 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.1 KOO32228.1 - 3.5e-11 41.9 11.0 9.8e-05 21.5 0.2 4.3 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.1 KOO32228.1 - 2.4e-09 36.6 8.5 0.0015 18.1 0.4 3.7 3 1 0 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.1 KOO32228.1 - 0.0087 15.9 0.0 4.9 7.1 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO32228.1 - 0.029 14.3 0.2 0.12 12.4 0.1 1.9 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF1997 PF09366.5 KOO32229.1 - 2.4e-05 24.1 0.0 5.5e-05 22.9 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1997) Thioredoxin_8 PF13905.1 KOO32230.1 - 4e-57 190.3 0.0 7.5e-28 96.4 0.0 3.1 3 0 0 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.16 KOO32230.1 - 2.2e-21 75.8 0.0 2.3e-10 40.2 0.0 2.3 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_2 PF13098.1 KOO32230.1 - 5.1e-20 71.7 0.0 5.2e-10 39.5 0.0 3.1 3 0 0 3 3 3 2 Thioredoxin-like domain Redoxin PF08534.5 KOO32230.1 - 8.9e-18 64.2 0.0 2.8e-09 36.6 0.0 2.4 1 1 1 2 2 2 2 Redoxin Thioredoxin PF00085.15 KOO32230.1 - 4.2e-15 55.3 0.0 3.9e-05 23.2 0.0 4.1 3 1 0 4 4 4 3 Thioredoxin Thioredoxin_7 PF13899.1 KOO32230.1 - 2.4e-05 24.2 0.0 0.029 14.3 0.0 3.0 2 1 0 2 2 2 2 Thioredoxin-like Thioredoxin_9 PF14595.1 KOO32230.1 - 4.5e-05 23.0 0.0 0.15 11.6 0.0 3.6 2 2 0 2 2 2 1 Thioredoxin TraF PF13728.1 KOO32230.1 - 0.012 15.0 0.0 2.6 7.4 0.0 2.5 2 1 0 2 2 2 0 F plasmid transfer operon protein DUF4609 PF15382.1 KOO32230.1 - 0.049 13.3 0.1 16 5.3 0.0 3.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4609) Glutaredoxin PF00462.19 KOO32230.1 - 0.33 10.9 2.4 18 5.4 0.1 3.3 2 2 0 2 2 2 0 Glutaredoxin AAA_30 PF13604.1 KOO32232.1 - 1.5e-23 83.4 0.0 3.5e-23 82.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.1 KOO32232.1 - 3.8e-22 78.3 0.1 9.3e-22 77.1 0.1 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain HHH_4 PF14490.1 KOO32232.1 - 7.9e-13 47.9 0.0 1.1e-11 44.2 0.0 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix containing domain Viral_helicase1 PF01443.13 KOO32232.1 - 4.3e-08 32.9 0.2 0.00011 21.8 0.0 2.8 2 1 1 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.1 KOO32232.1 - 4.2e-05 23.2 2.2 4.2e-05 23.2 1.5 3.8 2 1 0 2 2 2 1 Part of AAA domain AAA_11 PF13086.1 KOO32232.1 - 0.0013 18.3 0.2 0.0035 16.9 0.1 1.7 1 1 0 1 1 1 1 AAA domain UvrD_C PF13361.1 KOO32232.1 - 0.1 12.0 0.1 0.27 10.6 0.1 1.5 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain EF-hand_6 PF13405.1 KOO32234.1 - 3.4e-19 66.9 4.0 8e-05 22.2 0.1 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.27 KOO32234.1 - 1.1e-18 64.9 6.1 0.00034 19.7 0.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO32234.1 - 9.5e-18 64.0 2.5 4.7e-09 36.2 0.1 3.5 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.1 KOO32234.1 - 1.7e-13 49.9 3.1 7.9e-06 25.3 0.2 3.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO32234.1 - 1.1e-12 46.7 6.6 0.0014 17.9 0.1 5.1 5 0 0 5 5 5 4 EF hand EF-hand_9 PF14658.1 KOO32234.1 - 0.0079 16.0 0.0 0.54 10.2 0.0 3.5 3 0 0 3 3 3 1 EF-hand domain Myb_DNA-binding PF00249.26 KOO32235.1 - 3.7e-22 78.1 6.4 2.4e-11 43.5 0.9 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO32235.1 - 3.9e-18 65.2 6.2 2.5e-09 37.0 2.5 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain NTR2 PF15458.1 KOO32235.1 - 0.056 12.6 0.0 0.095 11.9 0.0 1.3 1 0 0 1 1 1 0 Nineteen complex-related protein 2 DUF4096 PF13340.1 KOO32235.1 - 0.065 13.1 2.0 5.3 6.9 0.0 3.2 3 0 0 3 3 3 0 Putative transposase of IS4/5 family (DUF4096) LRR_6 PF13516.1 KOO32236.1 - 1.7e-22 76.8 42.2 0.86 9.8 0.0 16.5 15 2 2 17 17 16 8 Leucine Rich repeat EF-hand_1 PF00036.27 KOO32236.1 - 1e-13 49.4 2.2 6.2e-07 28.2 0.1 3.1 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO32236.1 - 1.5e-13 49.3 1.3 1.8e-06 27.3 0.1 3.2 2 0 0 2 2 2 2 EF-hand domain LRR_4 PF12799.2 KOO32236.1 - 2.3e-13 49.4 32.4 0.00078 19.0 0.5 10.7 7 3 4 11 11 11 6 Leucine Rich repeats (2 copies) EF-hand_7 PF13499.1 KOO32236.1 - 1.5e-09 37.8 1.0 5.3e-09 36.0 0.7 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO32236.1 - 1.5e-08 33.5 3.7 0.00053 19.1 0.2 2.8 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO32236.1 - 2.6e-08 33.3 3.7 4e-07 29.5 0.6 2.5 1 1 1 2 2 2 2 EF-hand domain pair LRR_8 PF13855.1 KOO32236.1 - 2e-06 27.4 32.5 0.0076 15.9 0.5 8.4 7 2 1 8 8 8 3 Leucine rich repeat LRR_1 PF00560.28 KOO32236.1 - 0.0013 18.4 24.8 21 5.6 0.0 12.2 14 0 0 14 14 12 0 Leucine Rich Repeat UvrD-helicase PF00580.16 KOO32236.1 - 0.0023 17.3 0.3 0.16 11.2 0.0 2.4 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain LRR_7 PF13504.1 KOO32236.1 - 0.053 13.7 18.4 24 5.7 0.0 10.7 13 0 0 13 13 12 0 Leucine rich repeat KaiC PF06745.8 KOO32236.1 - 0.16 11.0 0.0 2.3 7.2 0.0 2.6 2 0 0 2 2 2 0 KaiC Asp_Arg_Hydrox PF05118.10 KOO32238.1 - 3.2e-29 101.8 0.0 5.8e-29 101.0 0.0 1.4 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase Lipase_3 PF01764.20 KOO32239.1 - 5.1e-21 74.7 0.0 6.8e-21 74.3 0.0 1.1 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 KOO32239.1 - 0.00041 20.1 0.1 0.00051 19.8 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO32239.1 - 0.032 14.1 0.2 0.038 13.8 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family VCBS PF13517.1 KOO32240.1 - 8.6e-79 259.8 90.1 3.3e-14 52.9 3.2 9.3 3 2 6 9 9 9 9 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO32240.1 - 3.3e-50 166.6 91.4 1.6e-06 27.6 1.2 9.9 10 0 0 10 10 10 9 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO32240.1 - 2.7e-16 59.5 39.2 0.18 11.2 0.1 9.1 3 3 6 9 9 9 9 Insecticide toxin TcdB middle/N-terminal region YuzL PF14115.1 KOO32240.1 - 0.00033 20.8 7.1 15 5.9 0.1 7.9 9 0 0 9 9 9 1 YuzL-like protein EF-hand_1 PF00036.27 KOO32240.1 - 0.021 14.0 37.5 17 4.9 0.1 9.4 9 0 0 9 9 9 0 EF hand BBS2_Mid PF14783.1 KOO32240.1 - 1.6 8.5 9.5 1.8e+02 1.9 0.0 6.7 9 0 0 9 9 9 0 Ciliary BBSome complex subunit 2, middle region Tuberculin PF12198.3 KOO32240.1 - 4.2 7.3 12.4 1.3 8.9 1.0 3.0 2 0 0 2 2 2 0 Theoretical tuberculin protein VCBS PF13517.1 KOO32242.1 - 1.6e-33 114.8 38.2 3.2e-15 56.2 4.9 3.4 1 1 3 4 4 4 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO32242.1 - 1e-20 72.7 17.8 1e-06 28.2 1.0 3.4 3 0 0 3 3 3 3 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO32242.1 - 4.4e-09 36.0 7.8 0.021 14.2 0.2 3.0 1 1 2 3 3 3 3 Insecticide toxin TcdB middle/N-terminal region EF-hand_1 PF00036.27 KOO32242.1 - 0.0033 16.6 7.5 4.9 6.6 0.1 3.4 3 0 0 3 3 3 3 EF hand EF-hand_5 PF13202.1 KOO32242.1 - 0.0055 15.9 14.5 1.6 8.2 0.5 3.6 3 0 0 3 3 3 3 EF hand YuzL PF14115.1 KOO32242.1 - 0.013 15.7 0.5 42 4.5 0.0 3.5 3 0 0 3 3 3 0 YuzL-like protein BBS2_Mid PF14783.1 KOO32242.1 - 0.096 12.4 0.2 66 3.3 0.0 3.0 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Excalibur PF05901.6 KOO32242.1 - 0.13 12.5 1.0 71 3.8 0.0 3.2 3 0 0 3 3 3 0 Excalibur calcium-binding domain Glucodextran_B PF09136.5 KOO32242.1 - 1.3 9.2 11.5 2 8.6 1.0 2.4 1 1 1 2 2 2 0 Glucodextranase, domain B WD40 PF00400.27 KOO32244.1 - 0.0034 17.2 0.4 3.4 7.6 0.0 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat VID27 PF08553.5 KOO32244.1 - 0.023 12.9 0.0 0.032 12.4 0.0 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein Histone PF00125.19 KOO32245.1 - 2e-09 37.4 4.4 0.00043 20.3 0.2 2.3 2 0 0 2 2 2 2 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 KOO32245.1 - 4.8e-08 32.9 1.0 0.00063 19.7 0.1 2.4 2 0 0 2 2 2 2 Histone-like transcription factor (CBF/NF-Y) and archaeal histone HTH_AsnC-type PF13404.1 KOO32245.1 - 0.0028 17.1 0.7 1 8.9 0.1 2.8 2 0 0 2 2 2 2 AsnC-type helix-turn-helix domain DUF937 PF06078.6 KOO32245.1 - 0.058 13.6 5.5 2.9 8.1 3.1 2.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF937) Bromo_TP PF07524.8 KOO32245.1 - 0.062 13.0 0.3 14 5.4 0.0 2.4 2 0 0 2 2 2 0 Bromodomain associated RRM_1 PF00076.17 KOO32246.1 - 2.7e-12 46.1 0.0 4.2e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO32246.1 - 2.1e-07 30.8 0.0 4.1e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO32246.1 - 2.9e-05 23.8 0.0 5.4e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1183 PF06682.7 KOO32246.1 - 0.07 12.7 2.4 0.094 12.3 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) Limkain-b1 PF11608.3 KOO32246.1 - 0.19 11.4 1.2 0.2 11.4 0.0 1.8 2 1 0 2 2 2 0 Limkain b1 Ank_2 PF12796.2 KOO32247.1 - 5.3e-10 39.5 0.8 6.1e-06 26.4 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) EF-hand_6 PF13405.1 KOO32247.1 - 2.5e-09 36.2 0.1 0.0055 16.4 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO32247.1 - 4.9e-09 36.2 0.8 1.7e-07 31.2 0.1 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO32247.1 - 2.1e-08 32.8 0.9 0.0021 17.2 0.2 2.7 2 0 0 2 2 2 2 EF hand Ank_5 PF13857.1 KOO32247.1 - 7.4e-08 32.3 0.9 0.0058 16.8 0.1 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO32247.1 - 4.6e-07 29.3 0.1 0.007 16.1 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.1 KOO32247.1 - 1.6e-06 27.7 0.6 0.29 11.5 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat EF-hand_8 PF13833.1 KOO32247.1 - 6.9e-06 25.5 0.1 9.1e-05 21.9 0.0 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO32247.1 - 8.5e-06 24.8 1.3 0.019 14.2 0.1 2.7 2 0 0 2 2 2 2 EF hand Ank_4 PF13637.1 KOO32247.1 - 0.007 16.8 2.2 0.42 11.2 0.0 3.6 4 0 0 4 4 4 1 Ankyrin repeats (many copies) ART PF01129.13 KOO32247.1 - 0.027 13.5 0.0 0.063 12.3 0.0 1.6 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase G6PD_bact PF10786.4 KOO32247.1 - 0.22 10.9 4.7 0.084 12.2 0.1 2.3 2 0 0 2 2 2 0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) ArfGap PF01412.13 KOO32248.1 - 3.6e-29 100.9 1.7 4.4e-29 100.6 1.2 1.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Thioredoxin_2 PF13098.1 KOO32248.1 - 0.015 15.4 0.0 0.024 14.8 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain DnaJ_CXXCXGXG PF00684.14 KOO32248.1 - 0.066 13.2 6.0 0.31 11.1 2.5 2.6 2 1 0 2 2 2 0 DnaJ central domain GRDA PF04723.9 KOO32248.1 - 0.1 12.3 0.1 0.12 12.0 0.1 1.2 1 0 0 1 1 1 0 Glycine reductase complex selenoprotein A UPF0075 PF03702.9 KOO32248.1 - 0.13 11.1 0.1 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0075) PKD_channel PF08016.7 KOO32250.1 - 2.6e-26 92.0 10.9 1e-24 86.7 8.4 2.0 2 0 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.26 KOO32250.1 - 6.9e-07 28.7 19.2 1.2e-06 27.9 13.3 1.3 1 0 0 1 1 1 1 Ion transport protein HTH_Tnp_IS1 PF12759.2 KOO32250.1 - 0.083 12.3 0.1 0.79 9.1 0.0 2.5 3 0 0 3 3 3 0 InsA C-terminal domain ATP-gua_Ptrans PF00217.14 KOO32251.1 - 3.5e-33 114.9 0.0 5.5e-33 114.2 0.0 1.2 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.10 KOO32251.1 - 2.3e-21 75.7 0.0 4.1e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain LRR_6 PF13516.1 KOO32251.1 - 1.4e-12 46.3 5.7 0.5 10.5 0.0 8.4 8 0 0 8 8 8 3 Leucine Rich repeat LRR_4 PF12799.2 KOO32251.1 - 3.5e-07 29.6 10.5 0.026 14.1 0.8 5.6 6 1 0 6 6 6 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO32251.1 - 1.1e-06 27.8 7.5 2.6 8.4 0.1 7.7 8 0 0 8 8 8 2 Leucine Rich Repeat LRR_8 PF13855.1 KOO32251.1 - 0.018 14.7 10.6 4.6 7.0 0.3 6.2 7 0 0 7 7 7 0 Leucine rich repeat LRR_7 PF13504.1 KOO32251.1 - 0.29 11.4 19.4 3.8 8.1 0.0 7.0 8 0 0 8 8 8 0 Leucine rich repeat SecA_SW PF07516.8 KOO32252.1 - 7e-36 123.9 0.0 1.1e-35 123.3 0.0 1.3 1 0 0 1 1 1 1 SecA Wing and Scaffold domain SecA_PP_bind PF01043.15 KOO32252.1 - 2.7e-28 98.6 0.3 1.3e-27 96.3 0.0 2.3 3 0 0 3 3 3 1 SecA preprotein cross-linking domain SecA_DEAD PF07517.9 KOO32252.1 - 3.3e-13 49.5 1.4 1.3e-12 47.5 0.0 2.3 3 0 0 3 3 3 1 SecA DEAD-like domain Helicase_C PF00271.26 KOO32252.1 - 0.051 13.4 0.8 11 5.9 0.0 2.7 2 0 0 2 2 2 0 Helicase conserved C-terminal domain SecA_DEAD PF07517.9 KOO32253.1 - 1.4e-88 296.6 0.0 1.8e-88 296.2 0.0 1.0 1 0 0 1 1 1 1 SecA DEAD-like domain DEAD PF00270.24 KOO32253.1 - 4.2e-06 26.3 0.0 7e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase BLOC1_2 PF10046.4 KOO32253.1 - 0.074 13.1 0.4 0.13 12.4 0.3 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 COesterase PF00135.23 KOO32254.1 - 1.2e-08 34.1 0.0 1.2e-08 34.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Pro_isomerase PF00160.16 KOO32255.1 - 4.2e-36 124.4 0.0 6.6e-36 123.8 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ank_2 PF12796.2 KOO32255.1 - 6.9e-13 48.7 3.0 2.1e-07 31.1 0.4 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO32255.1 - 3.5e-10 39.8 3.7 4e-08 33.2 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) FKBP_C PF00254.23 KOO32255.1 - 2.9e-09 36.8 0.0 5.9e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Nucleoporin_FG PF13634.1 KOO32255.1 - 1.7e-08 34.6 124.3 7.5e-06 26.1 30.0 5.3 1 1 2 3 3 3 2 Nucleoporin FG repeat region Ank PF00023.25 KOO32255.1 - 3.1e-08 33.0 0.5 0.01 15.5 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.1 KOO32255.1 - 4.4e-06 26.4 0.3 0.034 14.3 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOO32255.1 - 8e-06 26.2 0.5 0.0021 18.5 0.1 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) EGF_2 PF07974.8 KOO32258.1 - 8.4e-26 89.8 227.8 9.2e-05 22.5 4.2 13.4 12 1 0 12 12 12 10 EGF-like domain hEGF PF12661.2 KOO32258.1 - 7.3e-06 25.7 121.7 0.062 13.4 0.3 13.8 14 0 0 14 14 14 10 Human growth factor-like EGF Lipase_3 PF01764.20 KOO32259.1 - 3.6e-17 62.3 0.0 5.7e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 KOO32259.1 - 0.022 14.5 0.1 0.022 14.5 0.1 2.3 2 1 0 2 2 2 0 Alpha/beta hydrolase family Esterase PF00756.15 KOO32259.1 - 0.1 12.0 1.0 5.2 6.4 0.1 2.3 2 0 0 2 2 2 0 Putative esterase Sporozoite_P67 PF05642.6 KOO32259.1 - 0.47 8.2 1.6 0.66 7.7 1.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen HC2 PF07382.6 KOO32260.1 - 0.0077 16.1 15.8 0.0077 16.1 10.9 2.6 3 0 0 3 3 3 1 Histone H1-like nucleoprotein HC2 Glyco_transf_34 PF05637.7 KOO32260.1 - 0.027 13.9 0.1 0.059 12.8 0.0 1.5 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family AP2 PF00847.15 KOO32261.1 - 9.9e-06 25.6 0.5 2.2e-05 24.5 0.4 1.7 1 0 0 1 1 1 1 AP2 domain SBBP PF06739.6 KOO32262.1 - 0.0018 18.0 11.1 0.063 13.0 0.3 3.3 3 0 0 3 3 3 3 Beta-propeller repeat DUF2883 PF11097.3 KOO32262.1 - 0.14 12.3 0.0 16 5.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2883) PKD_channel PF08016.7 KOO32263.1 - 6e-30 104.0 16.8 1.3e-29 102.9 9.5 2.5 3 0 0 3 3 3 1 Polycystin cation channel Ion_trans PF00520.26 KOO32263.1 - 1.6e-05 24.2 20.3 3.7e-05 23.0 14.0 1.6 1 0 0 1 1 1 1 Ion transport protein IncA PF04156.9 KOO32263.1 - 0.07 12.7 0.1 0.07 12.7 0.1 1.6 2 0 0 2 2 2 0 IncA protein AP2 PF00847.15 KOO32264.1 - 5.7e-08 32.7 7.8 0.019 15.1 0.1 4.6 4 0 0 4 4 4 3 AP2 domain IF3_N PF05198.11 KOO32264.1 - 0.13 12.1 8.4 14 5.7 0.4 4.2 4 1 0 4 4 4 0 Translation initiation factor IF-3, N-terminal domain UPF0061 PF02696.9 KOO32265.1 - 2.9e-66 223.7 0.0 5.9e-66 222.7 0.0 1.5 1 1 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family ABC2_membrane_3 PF12698.2 KOO32266.1 - 2.3e-22 79.4 22.7 2.4e-21 76.1 12.9 2.1 2 0 0 2 2 2 2 ABC-2 family transporter protein ABC2_membrane PF01061.19 KOO32266.1 - 7e-05 22.0 19.0 7e-05 22.0 13.2 1.9 1 1 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_2 PF12679.2 KOO32266.1 - 0.23 10.3 21.4 0.47 9.2 14.2 1.9 1 1 0 1 1 1 0 ABC-2 family transporter protein Pro_isomerase PF00160.16 KOO32267.1 - 4.4e-09 36.7 0.0 7.6e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD LRR_6 PF13516.1 KOO32268.1 - 0.004 17.0 0.0 0.01 15.8 0.0 1.6 1 0 0 1 1 1 1 Leucine Rich repeat SpoU_methylase PF00588.14 KOO32270.1 - 4.3e-15 55.8 0.0 1.9e-06 27.8 0.0 2.9 3 0 0 3 3 3 2 SpoU rRNA Methylase family DUF952 PF06108.7 KOO32271.1 - 1.6e-07 31.0 0.0 2.7e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF952) Cupin_3 PF05899.7 KOO32271.1 - 4.1e-05 22.8 0.1 8.4e-05 21.8 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_2 PF07883.6 KOO32271.1 - 0.15 11.5 0.0 0.15 11.5 0.0 1.6 2 0 0 2 2 2 0 Cupin domain zf-Tim10_DDP PF02953.10 KOO32272.1 - 1.1e-21 75.8 5.3 1.3e-21 75.6 3.6 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.8 KOO32272.1 - 0.026 13.9 5.3 0.033 13.6 3.7 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) SPC22 PF04573.7 KOO32272.1 - 0.13 11.5 0.0 0.13 11.4 0.0 1.0 1 0 0 1 1 1 0 Signal peptidase subunit Galactosyl_T PF01762.16 KOO32273.1 - 0.00056 19.5 0.0 0.5 9.9 0.0 2.5 2 1 0 2 2 2 2 Galactosyltransferase Fringe PF02434.11 KOO32273.1 - 0.18 11.0 0.0 0.32 10.1 0.0 1.3 1 0 0 1 1 1 0 Fringe-like Ank PF00023.25 KOO32274.1 - 1.4e-28 97.1 19.5 6e-09 35.2 0.3 7.3 7 0 0 7 7 7 6 Ankyrin repeat Ank_2 PF12796.2 KOO32274.1 - 2.5e-28 98.2 13.7 1.4e-12 47.7 0.6 4.1 1 1 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO32274.1 - 5.4e-26 90.4 11.1 1.6e-05 25.2 0.0 6.2 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO32274.1 - 6.1e-22 75.5 9.7 3.6e-06 26.6 0.0 8.1 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.1 KOO32274.1 - 4.7e-14 52.0 14.1 6.3e-05 23.0 0.2 5.2 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Methyltransf_11 PF08241.7 KOO32277.1 - 1.2e-10 41.7 0.0 2.1e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO32277.1 - 7.5e-07 28.9 0.0 1.1e-06 28.4 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO32277.1 - 3.4e-06 27.3 0.0 6.7e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO32277.1 - 8.7e-05 22.9 0.0 0.0002 21.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO32277.1 - 0.00049 19.2 0.0 0.00066 18.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 KOO32277.1 - 0.0007 19.2 0.0 0.00094 18.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.11 KOO32277.1 - 0.024 12.9 0.0 0.032 12.5 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_18 PF12847.2 KOO32277.1 - 0.028 15.0 0.0 0.044 14.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Ion_trans PF00520.26 KOO32278.1 - 4.4e-11 42.4 2.7 6.9e-11 41.7 1.8 1.3 1 0 0 1 1 1 1 Ion transport protein WW PF00397.21 KOO32279.1 - 7.6e-11 41.6 0.5 1.4e-10 40.7 0.3 1.5 1 0 0 1 1 1 1 WW domain DUF4440 PF14534.1 KOO32279.1 - 0.11 12.6 0.1 1 9.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4440) Hydrophobin_2 PF06766.6 KOO32279.1 - 0.12 12.0 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Fungal hydrophobin PTPA PF03095.10 KOO32281.1 - 3.5e-103 344.8 0.0 1e-84 284.2 0.0 2.0 2 0 0 2 2 2 2 Phosphotyrosyl phosphate activator (PTPA) protein RCC1_2 PF13540.1 KOO32282.1 - 4.1e-24 83.5 38.5 2.2e-06 27.0 0.6 6.6 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.13 KOO32282.1 - 2.2e-21 75.8 36.8 0.00011 22.3 0.3 6.7 6 1 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat Nop10p PF04135.7 KOO32282.1 - 0.14 11.8 21.8 3.8 7.3 1.5 3.9 3 0 0 3 3 3 0 Nucleolar RNA-binding protein, Nop10p family Pkinase PF00069.20 KOO32283.1 - 4.2e-67 226.0 0.0 5e-67 225.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32283.1 - 2.7e-35 121.7 0.0 3.6e-35 121.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO32283.1 - 5.8e-07 28.7 0.0 1.8e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 Kinase-like cNMP_binding PF00027.24 KOO32283.1 - 0.0011 18.7 0.0 0.0037 17.0 0.0 1.8 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Sel1 PF08238.7 KOO32284.1 - 1.7e-16 60.2 1.4 2.9e-05 24.5 0.6 3.7 3 0 0 3 3 3 3 Sel1 repeat U-box PF04564.10 KOO32284.1 - 5.1e-13 48.7 0.0 8.2e-13 48.1 0.0 1.3 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO32284.1 - 0.00092 18.6 0.2 0.0031 16.9 0.0 1.9 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit DIOX_N PF14226.1 KOO32285.1 - 2.7e-21 76.2 0.0 4.2e-21 75.6 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 KOO32285.1 - 1.4e-11 44.5 0.0 2.2e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CG-1 PF03859.11 KOO32286.1 - 1.2e-18 66.7 0.2 1.8e-18 66.2 0.1 1.1 1 0 0 1 1 1 1 CG-1 domain DUF1298 PF06974.8 KOO32287.1 - 7.9e-09 35.4 0.0 1.2e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1298) Condensation PF00668.15 KOO32287.1 - 2.5e-05 23.2 0.1 0.0066 15.3 0.0 2.4 3 0 0 3 3 3 2 Condensation domain LRR_6 PF13516.1 KOO32288.1 - 1.1e-05 24.9 0.3 0.11 12.6 0.0 2.7 2 0 0 2 2 2 2 Leucine Rich repeat NACHT PF05729.7 KOO32288.1 - 0.0038 16.9 2.2 0.012 15.2 1.4 1.9 1 1 0 1 1 1 1 NACHT domain AAA_25 PF13481.1 KOO32288.1 - 0.0043 16.4 0.9 0.0093 15.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KOO32288.1 - 0.016 14.9 0.0 0.11 12.2 0.0 2.5 1 0 0 1 1 1 0 Part of AAA domain CorA PF01544.13 KOO32288.1 - 1.3 8.0 3.6 2.3 7.1 2.5 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein His_Phos_1 PF00300.17 KOO32289.1 - 3.3e-13 50.0 0.1 6.9e-13 48.9 0.1 1.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) U79_P34 PF03064.11 KOO32289.1 - 0.13 11.8 0.1 1.3 8.4 0.0 2.1 2 0 0 2 2 2 0 HSV U79 / HCMV P34 Sel1 PF08238.7 KOO32290.1 - 2.3e-16 59.8 13.5 2.3e-05 24.8 1.6 4.4 4 0 0 4 4 4 3 Sel1 repeat U-box PF04564.10 KOO32290.1 - 1.4e-11 44.1 0.0 2.4e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO32290.1 - 0.0018 17.7 0.0 0.0039 16.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Sel1 PF08238.7 KOO32291.1 - 3.2e-14 53.0 14.3 4.6e-07 30.2 1.8 4.0 4 0 0 4 4 4 3 Sel1 repeat U-box PF04564.10 KOO32291.1 - 3.6e-12 46.0 0.0 6.6e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO32291.1 - 0.00046 19.6 0.0 0.00086 18.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit TPR_6 PF13174.1 KOO32291.1 - 0.026 14.9 2.6 0.17 12.4 0.3 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF469 PF04320.9 KOO32291.1 - 0.054 14.2 0.0 3.7 8.3 0.0 2.7 2 0 0 2 2 2 0 Protein with unknown function (DUF469) Sigma70_r3 PF04539.11 KOO32291.1 - 0.16 11.8 1.4 0.17 11.8 0.0 1.7 2 0 0 2 2 2 0 Sigma-70 region 3 Sel1 PF08238.7 KOO32292.1 - 9.4e-16 57.8 6.3 1.8e-07 31.5 1.0 3.4 3 0 0 3 3 3 3 Sel1 repeat zf-Nse PF11789.3 KOO32292.1 - 0.066 12.7 0.3 1.7 8.2 0.0 2.8 3 0 0 3 3 3 0 Zinc-finger of the MIZ type in Nse subunit CZB PF13682.1 KOO32292.1 - 0.12 12.5 0.4 0.21 11.8 0.3 1.4 1 0 0 1 1 1 0 Chemoreceptor zinc-binding domain Sel1 PF08238.7 KOO32293.1 - 2.6e-13 50.1 16.5 8.8e-08 32.5 1.2 4.2 4 0 0 4 4 4 3 Sel1 repeat U-box PF04564.10 KOO32293.1 - 1.8e-12 47.0 0.0 3.9e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO32293.1 - 0.00055 19.3 0.4 0.0012 18.3 0.0 1.7 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit Sigma70_r3 PF04539.11 KOO32293.1 - 0.16 11.8 0.1 0.16 11.8 0.0 1.7 2 0 0 2 2 2 0 Sigma-70 region 3 Nucleotid_trans PF03407.11 KOO32294.1 - 1.8e-18 67.0 0.0 9.7e-09 35.3 0.1 2.4 2 0 0 2 2 2 2 Nucleotide-diphospho-sugar transferase LRR_4 PF12799.2 KOO32295.1 - 2.1e-27 94.1 4.2 5.4e-06 25.8 0.2 4.2 3 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO32295.1 - 4.7e-23 80.7 24.1 3e-08 33.2 0.2 4.3 2 2 2 4 4 4 4 Leucine rich repeat LRR_1 PF00560.28 KOO32295.1 - 4.6e-16 56.3 6.8 0.12 12.4 0.7 7.9 6 2 0 6 6 6 5 Leucine Rich Repeat LRR_7 PF13504.1 KOO32295.1 - 1.1e-11 42.8 16.2 0.086 13.0 0.1 8.2 8 0 0 8 8 8 4 Leucine rich repeat LRR_9 PF14580.1 KOO32295.1 - 0.00054 19.5 1.4 0.013 15.0 0.2 2.4 1 1 2 3 3 3 1 Leucine-rich repeat LRR_6 PF13516.1 KOO32295.1 - 0.0026 17.6 5.9 16 5.9 0.1 6.4 7 1 1 8 8 8 1 Leucine Rich repeat Pkinase PF00069.20 KOO32295.1 - 0.011 14.8 0.0 0.015 14.4 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32295.1 - 0.056 12.5 0.0 0.088 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase 6PGD PF00393.14 KOO32296.1 - 1.8e-67 227.6 0.0 2.6e-67 227.1 0.0 1.2 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 KOO32296.1 - 8.6e-41 139.4 0.3 1.3e-40 138.8 0.2 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.13 KOO32296.1 - 0.00025 20.7 0.0 0.00044 19.9 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_11 PF14833.1 KOO32296.1 - 0.014 15.4 0.2 0.032 14.3 0.1 1.7 1 1 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_Gly3P_dh_N PF01210.18 KOO32296.1 - 0.059 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus IlvN PF07991.7 KOO32296.1 - 0.11 11.9 0.7 0.85 8.9 0.0 2.5 3 0 0 3 3 3 0 Acetohydroxy acid isomeroreductase, catalytic domain EF-hand_7 PF13499.1 KOO32297.1 - 1e-09 38.4 0.2 2.2e-09 37.3 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO32297.1 - 1.5e-06 27.0 1.9 0.00011 21.2 0.4 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO32297.1 - 7.7e-06 25.3 0.3 0.00017 21.1 0.2 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.1 KOO32297.1 - 2.1e-05 23.6 2.6 0.0015 17.7 0.4 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO32297.1 - 0.00089 18.8 2.9 0.0026 17.3 0.4 2.3 1 1 1 2 2 2 2 EF-hand domain pair FeThRed_B PF02943.10 KOO32298.1 - 1.8e-36 124.1 2.6 2.6e-36 123.6 1.8 1.2 1 0 0 1 1 1 1 Ferredoxin thioredoxin reductase catalytic beta chain Endothelin PF00322.12 KOO32298.1 - 0.16 11.1 0.1 0.16 11.1 0.1 2.0 2 0 0 2 2 2 0 Endothelin family GRIP PF01465.15 KOO32299.1 - 0.0059 16.1 0.0 0.014 14.8 0.0 1.5 1 0 0 1 1 1 1 GRIP domain EF-hand_1 PF00036.27 KOO32301.1 - 4.3e-27 91.3 9.1 1.6e-08 33.2 0.3 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO32301.1 - 6.5e-25 87.0 5.6 7.9e-14 51.5 0.3 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO32301.1 - 2.8e-24 82.7 5.0 5.1e-09 35.2 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 KOO32301.1 - 9.2e-23 79.6 15.3 1.5e-10 40.5 0.1 3.8 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO32301.1 - 3.5e-14 51.3 11.8 6.3e-06 25.2 0.3 4.1 4 1 0 4 4 4 3 EF hand EF-hand_9 PF14658.1 KOO32301.1 - 1.2e-13 50.7 0.2 8.5e-06 25.5 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 KOO32301.1 - 2e-06 27.4 2.6 0.073 12.8 0.1 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Acetyltransf_11 PF13720.1 KOO32301.1 - 0.005 17.0 0.1 2.4 8.4 0.0 2.4 2 1 0 2 2 2 2 Udp N-acetylglucosamine O-acyltransferase; Domain 2 MgtE_N PF03448.12 KOO32301.1 - 0.013 15.8 1.4 0.021 15.1 0.1 1.9 2 1 0 2 2 2 0 MgtE intracellular N domain Ribosomal_L11 PF00298.14 KOO32301.1 - 0.027 14.6 0.1 1.4 9.1 0.0 2.6 3 1 0 3 3 3 0 Ribosomal protein L11, RNA binding domain Toprim_2 PF13155.1 KOO32301.1 - 0.18 12.1 0.7 24 5.3 0.1 2.6 1 1 0 2 2 2 0 Toprim-like NAD_binding_10 PF13460.1 KOO32302.1 - 2.2e-17 63.6 0.0 3.9e-17 62.8 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 KOO32302.1 - 1.3e-15 57.5 0.0 4e-14 52.6 0.0 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 KOO32302.1 - 8e-06 24.9 0.0 5.1e-05 22.2 0.0 1.9 2 0 0 2 2 2 1 RmlD substrate binding domain TylF PF05711.6 KOO32303.1 - 6.9e-22 77.7 0.0 9.2e-22 77.3 0.0 1.1 1 0 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.1 KOO32303.1 - 0.0031 18.3 0.0 0.004 17.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain EF-hand_6 PF13405.1 KOO32304.1 - 1e-27 93.4 14.1 3.5e-06 26.4 0.0 6.8 6 0 0 6 6 6 6 EF-hand domain EF-hand_1 PF00036.27 KOO32304.1 - 1.3e-27 92.9 18.9 1.3e-05 24.1 0.2 6.8 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.1 KOO32304.1 - 1.6e-25 88.9 13.3 2.6e-09 37.0 0.4 5.2 3 2 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO32304.1 - 4.9e-18 63.5 17.7 0.00014 21.0 0.5 6.8 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.1 KOO32304.1 - 3.5e-14 52.1 19.3 9.4e-05 21.9 0.7 6.3 4 2 2 6 6 6 5 EF-hand domain pair DUF1116 PF06545.6 KOO32305.1 - 5e-70 234.9 0.0 7.5e-70 234.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1116) Isochorismatase PF00857.15 KOO32305.1 - 4.9e-37 127.5 0.0 9.4e-37 126.6 0.0 1.4 1 0 0 1 1 1 1 Isochorismatase family Gallidermin PF02052.10 KOO32306.1 - 0.13 12.3 0.1 0.4 10.8 0.0 1.9 2 0 0 2 2 2 0 Gallidermin NAD_binding_10 PF13460.1 KOO32307.1 - 3e-28 99.0 0.2 4.2e-28 98.5 0.1 1.2 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 KOO32307.1 - 8.9e-08 31.6 0.6 0.0099 15.1 0.4 3.0 3 1 0 3 3 3 2 NmrA-like family 3Beta_HSD PF01073.14 KOO32307.1 - 8e-07 28.0 0.0 0.0042 15.8 0.1 2.1 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.15 KOO32307.1 - 1.8e-06 27.8 0.3 2.9e-06 27.1 0.2 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.16 KOO32307.1 - 5.4e-06 26.0 0.0 0.00067 19.1 0.0 2.3 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.19 KOO32307.1 - 5.7e-05 23.4 0.2 0.0001 22.5 0.1 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain TrkA_N PF02254.13 KOO32307.1 - 6.6e-05 22.8 0.1 0.00011 22.2 0.0 1.3 1 0 0 1 1 1 1 TrkA-N domain Polysacc_synt_2 PF02719.10 KOO32307.1 - 0.00034 19.6 0.0 0.64 8.8 0.0 2.2 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein Shikimate_DH PF01488.15 KOO32307.1 - 0.00074 19.6 0.0 0.0012 18.9 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase adh_short PF00106.20 KOO32307.1 - 0.0094 15.8 3.8 0.059 13.2 0.9 2.4 3 0 0 3 3 3 1 short chain dehydrogenase Saccharop_dh PF03435.13 KOO32307.1 - 0.015 14.2 0.6 0.065 12.1 0.4 1.8 2 0 0 2 2 2 0 Saccharopine dehydrogenase KR PF08659.5 KOO32307.1 - 0.018 14.7 0.6 0.039 13.5 0.2 1.7 2 0 0 2 2 2 0 KR domain Ldh_1_N PF00056.18 KOO32307.1 - 0.022 14.5 0.3 0.25 11.1 0.3 2.1 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain GARS_N PF02844.10 KOO32307.1 - 0.054 13.9 0.2 0.14 12.6 0.1 1.7 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, N domain GFO_IDH_MocA PF01408.17 KOO32307.1 - 0.064 13.7 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold CoA_binding PF02629.14 KOO32307.1 - 0.31 11.5 0.2 0.31 11.5 0.1 2.2 3 0 0 3 3 2 0 CoA binding domain RmlD_sub_bind PF04321.12 KOO32307.1 - 0.47 9.2 2.1 0.27 10.0 0.1 1.5 2 0 0 2 2 2 0 RmlD substrate binding domain eIF-5a PF01287.15 KOO32308.1 - 3e-18 65.5 0.0 4.5e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.7 KOO32308.1 - 0.0009 19.0 1.3 0.001 18.8 0.1 1.8 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain KOW PF00467.24 KOO32308.1 - 0.0027 17.3 0.1 0.0058 16.3 0.1 1.6 1 0 0 1 1 1 1 KOW motif Rcd1 PF04078.8 KOO32309.1 - 6.7e-132 438.1 0.2 7.8e-132 437.9 0.1 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Ank_2 PF12796.2 KOO32310.1 - 7.6e-50 167.2 30.3 2.3e-15 56.6 1.1 5.6 1 1 5 6 6 6 5 Ankyrin repeats (3 copies) Ank PF00023.25 KOO32310.1 - 1.6e-31 106.4 38.2 4.8e-06 26.1 0.5 9.6 10 0 0 10 10 10 8 Ankyrin repeat Ank_4 PF13637.1 KOO32310.1 - 8.8e-31 105.7 11.6 4.5e-08 33.3 0.1 6.3 3 2 3 6 6 6 6 Ankyrin repeats (many copies) Pkinase PF00069.20 KOO32310.1 - 1.7e-30 106.0 0.0 3.8e-30 104.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Ank_5 PF13857.1 KOO32310.1 - 1.2e-28 98.4 27.2 3e-07 30.4 0.1 8.0 1 1 7 8 8 8 8 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.12 KOO32310.1 - 5.8e-22 77.9 0.0 1.2e-21 76.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_3 PF13606.1 KOO32310.1 - 9.9e-17 59.3 18.0 0.00021 21.2 0.1 8.8 8 0 0 8 8 8 3 Ankyrin repeat ScpA_ScpB PF02616.9 KOO32310.1 - 0.081 12.4 0.2 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 ScpA/B protein Kinase-like PF14531.1 KOO32310.1 - 0.091 11.7 0.0 0.19 10.6 0.0 1.4 1 0 0 1 1 1 0 Kinase-like DUF4182 PF13790.1 KOO32310.1 - 0.22 11.3 4.5 12 5.8 0.1 3.9 5 0 0 5 5 5 0 Domain of unknown function (DUF4182) Orthopox_F8 PF05886.6 KOO32310.1 - 0.65 9.8 2.5 0.66 9.8 0.5 1.9 2 0 0 2 2 2 0 Orthopoxvirus F8 protein KAP_NTPase PF07693.9 KOO32310.1 - 0.77 8.6 2.2 1.3 7.8 1.5 1.3 1 0 0 1 1 1 0 KAP family P-loop domain Phospholip_A2_2 PF05826.7 KOO32310.1 - 0.87 9.5 3.3 9.1 6.3 0.1 2.8 2 1 1 3 3 3 0 Phospholipase A2 DUF872 PF05915.7 KOO32311.1 - 0.0026 17.5 0.5 0.0077 16.0 0.4 1.7 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) C2 PF00168.25 KOO32312.1 - 1.8e-58 194.3 0.0 3.8e-14 52.2 0.0 6.5 6 0 0 6 6 6 5 C2 domain FerI PF08151.7 KOO32312.1 - 9.8e-08 31.9 0.0 4.1e-07 29.9 0.0 2.1 1 0 0 1 1 1 1 FerI (NUC094) domain BBS2_C PF14782.1 KOO32312.1 - 0.4 9.1 4.3 0.67 8.4 3.0 1.2 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal DUF1764 PF08576.5 KOO32312.1 - 0.92 10.3 4.0 0.53 11.0 0.1 2.6 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Matrilin_ccoil PF10393.4 KOO32312.1 - 4.2 6.8 6.6 0.61 9.5 1.1 2.2 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin Pkinase PF00069.20 KOO32313.1 - 1.1e-63 214.8 0.0 1.8e-63 214.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32313.1 - 1.5e-32 112.7 0.0 2.3e-32 112.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.1 KOO32313.1 - 3.9e-19 68.5 13.9 2.1e-08 34.1 0.1 3.4 1 1 4 5 5 5 4 EF-hand domain pair EF-hand_8 PF13833.1 KOO32313.1 - 1.7e-16 59.5 10.7 8.4e-06 25.3 0.8 4.5 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO32313.1 - 3.5e-15 54.4 3.4 1.1e-05 24.9 0.0 4.1 3 1 1 4 4 4 3 EF-hand domain EF-hand_1 PF00036.27 KOO32313.1 - 5.5e-14 50.3 5.6 2.7e-05 23.1 0.0 4.3 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.1 KOO32313.1 - 5.8e-12 44.3 0.3 6.5e-06 25.2 0.0 3.1 2 0 0 2 2 2 2 EF hand NADPH_Ox PF08414.5 KOO32313.1 - 0.00035 20.6 0.1 0.078 13.0 0.0 3.0 2 1 1 3 3 3 1 Respiratory burst NADPH oxidase YrbL-PhoP_reg PF10707.4 KOO32313.1 - 0.0005 19.4 0.2 0.00097 18.5 0.1 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kinase-like PF14531.1 KOO32313.1 - 0.00053 19.0 0.0 0.00089 18.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like HisKA PF00512.20 KOO32313.1 - 0.021 14.7 0.0 0.19 11.7 0.0 2.5 2 0 0 2 2 2 0 His Kinase A (phospho-acceptor) domain Chloroa_b-bind PF00504.16 KOO32314.1 - 2.2e-30 105.9 0.4 2.7e-30 105.7 0.3 1.0 1 0 0 1 1 1 1 Chlorophyll A-B binding protein PDZ PF00595.19 KOO32315.1 - 6.3e-06 26.2 0.0 1.5e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Skp1 PF01466.14 KOO32317.1 - 0.0037 17.2 0.0 0.011 15.7 0.0 1.7 2 0 0 2 2 2 1 Skp1 family, dimerisation domain WD40 PF00400.27 KOO32318.1 - 2.1e-52 173.2 22.6 3.2e-10 39.5 0.0 11.6 12 0 0 12 12 12 8 WD domain, G-beta repeat PQQ_2 PF13360.1 KOO32318.1 - 8.9e-09 35.1 2.4 0.00015 21.2 0.2 3.7 2 2 2 4 4 4 2 PQQ-like domain Nup160 PF11715.3 KOO32318.1 - 6.3e-08 31.2 2.4 0.084 10.9 0.0 4.3 4 1 0 4 4 4 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.11 KOO32318.1 - 0.034 12.4 0.4 7 4.8 0.1 3.5 3 1 0 3 3 3 0 Cytochrome D1 heme domain NifZ PF04319.8 KOO32318.1 - 0.052 12.9 0.0 4.8 6.6 0.0 2.6 2 0 0 2 2 2 0 NifZ domain PQQ_3 PF13570.1 KOO32318.1 - 0.1 12.8 15.3 26 5.2 0.1 8.2 9 1 0 9 9 9 0 PQQ-like domain Hira PF07569.6 KOO32318.1 - 0.11 11.6 0.2 35 3.4 0.0 3.8 4 0 0 4 4 4 0 TUP1-like enhancer of split Nucleotid_trans PF03407.11 KOO32319.1 - 5.9e-33 114.4 0.1 1e-32 113.6 0.0 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Peptidase_M18 PF02127.10 KOO32320.1 - 2.2e-140 468.0 0.0 2.9e-79 266.6 0.0 2.0 2 0 0 2 2 2 2 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.9 KOO32320.1 - 2.3e-06 26.6 0.0 0.00096 18.0 0.0 2.1 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase Peptidase_M20 PF01546.23 KOO32320.1 - 0.032 13.7 0.0 0.076 12.5 0.0 1.6 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 RVT_2 PF07727.9 KOO32321.1 - 1.2e-17 63.7 0.0 1.7e-17 63.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Melibiase PF02065.13 KOO32321.1 - 1.1e-16 60.5 0.1 4.1e-10 38.9 0.0 2.2 1 1 1 2 2 2 2 Melibiase ShK PF01549.19 KOO32321.1 - 2.1e-06 27.9 9.2 6e-06 26.5 6.4 1.9 1 0 0 1 1 1 1 ShK domain-like PPDK_N PF01326.14 KOO32322.1 - 2.2e-41 141.9 0.0 6.8e-41 140.3 0.0 1.7 1 1 0 1 1 1 1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain Response_reg PF00072.19 KOO32322.1 - 0.00076 19.4 0.0 0.015 15.2 0.0 2.5 2 0 0 2 2 2 1 Response regulator receiver domain APH PF01636.18 KOO32323.1 - 9.6e-43 146.6 1.1 9.6e-43 146.6 0.7 1.9 2 1 0 2 2 2 1 Phosphotransferase enzyme family adh_short PF00106.20 KOO32323.1 - 2.8e-23 82.6 1.3 8.5e-23 81.0 0.9 1.9 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOO32323.1 - 6.1e-10 39.0 0.2 1.5e-09 37.8 0.2 1.6 1 0 0 1 1 1 1 KR domain EcKinase PF02958.15 KOO32323.1 - 3.5e-07 29.6 0.0 5.5e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.6 KOO32323.1 - 0.00036 19.3 0.0 0.00053 18.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Choline_kinase PF01633.15 KOO32323.1 - 0.012 15.1 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase VWA_CoxE PF05762.9 KOO32323.1 - 0.018 14.1 0.6 0.041 13.0 0.4 1.5 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein Fructosamin_kin PF03881.9 KOO32323.1 - 0.029 13.3 0.0 0.51 9.2 0.0 2.1 2 0 0 2 2 2 0 Fructosamine kinase RIO1 PF01163.17 KOO32323.1 - 0.055 12.8 0.0 1.1 8.5 0.0 2.2 2 0 0 2 2 2 0 RIO1 family LRR_4 PF12799.2 KOO32324.1 - 8.3e-18 63.6 5.9 4.6e-07 29.3 1.1 4.6 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) Zeta_toxin PF06414.7 KOO32324.1 - 1.1e-15 57.2 1.0 1.3e-08 34.2 0.0 2.9 3 0 0 3 3 3 2 Zeta toxin LRR_8 PF13855.1 KOO32324.1 - 5.3e-11 42.1 11.4 4.2e-05 23.2 1.1 3.6 2 1 3 5 5 5 3 Leucine rich repeat LRR_1 PF00560.28 KOO32324.1 - 2e-10 39.2 7.0 0.13 12.3 0.2 7.1 7 0 0 7 7 7 3 Leucine Rich Repeat AAA_33 PF13671.1 KOO32324.1 - 3.3e-06 27.0 0.0 9.7e-05 22.2 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KOO32324.1 - 5.8e-05 23.1 4.9 0.023 14.7 0.0 3.8 3 0 0 3 3 3 1 AAA ATPase domain AAA_17 PF13207.1 KOO32324.1 - 0.0003 21.6 0.1 0.0024 18.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain LRR_6 PF13516.1 KOO32324.1 - 0.00046 19.9 7.9 4 7.8 0.2 5.7 6 0 0 6 6 6 2 Leucine Rich repeat AAA PF00004.24 KOO32324.1 - 0.0027 17.9 0.1 0.022 14.9 0.0 2.6 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Leucyl-specific PF14795.1 KOO32324.1 - 0.0031 17.3 0.1 0.022 14.6 0.0 2.6 1 0 0 1 1 1 1 Leucine-tRNA synthetase-specific domain ABC_tran PF00005.22 KOO32324.1 - 0.0053 17.0 1.0 0.042 14.1 0.0 2.8 3 0 0 3 3 3 1 ABC transporter AAA_22 PF13401.1 KOO32324.1 - 0.0086 16.2 0.0 0.049 13.7 0.0 2.4 2 0 0 2 2 1 1 AAA domain AAA_21 PF13304.1 KOO32324.1 - 0.01 15.8 0.0 0.023 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.1 KOO32324.1 - 0.013 15.3 0.0 0.047 13.5 0.0 2.0 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 KOO32324.1 - 0.12 12.0 3.6 0.3 10.7 0.0 2.7 2 1 0 2 2 2 0 Archaeal ATPase RNA_helicase PF00910.17 KOO32324.1 - 0.17 12.0 0.0 0.44 10.7 0.0 1.7 1 0 0 1 1 1 0 RNA helicase LRR_7 PF13504.1 KOO32324.1 - 9.5 6.9 18.9 2.4 8.7 0.2 6.5 8 0 0 8 8 6 0 Leucine rich repeat Aldo_ket_red PF00248.16 KOO32325.1 - 1.3e-23 83.1 0.0 1.5e-23 83.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Ank_2 PF12796.2 KOO32327.1 - 5.2e-38 129.2 8.6 4.3e-18 65.4 0.4 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO32327.1 - 5.9e-33 111.0 7.0 3.8e-06 26.4 0.1 6.1 5 1 1 6 6 6 5 Ankyrin repeat Ank_4 PF13637.1 KOO32327.1 - 1.1e-21 76.7 2.9 1.1e-07 32.2 0.0 4.0 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO32327.1 - 1.1e-21 76.3 4.4 9.5e-05 22.5 0.1 5.8 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO32327.1 - 1.8e-20 70.9 1.1 0.0012 18.9 0.0 6.1 6 0 0 6 6 6 4 Ankyrin repeat ING PF12998.2 KOO32328.1 - 0.047 13.9 0.3 0.1 12.8 0.2 1.5 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding Filamin PF00630.14 KOO32329.1 - 1.2e-25 90.0 0.0 1.2e-06 28.9 0.0 5.1 4 1 1 5 5 5 4 Filamin/ABP280 repeat CAP_GLY PF01302.20 KOO32329.1 - 7.9e-16 57.5 1.2 1.8e-15 56.3 0.6 1.8 2 0 0 2 2 2 1 CAP-Gly domain Y_Y_Y PF07495.8 KOO32329.1 - 0.027 14.2 0.0 5.8 6.7 0.0 2.4 2 0 0 2 2 2 0 Y_Y_Y domain Defensin_4 PF07936.7 KOO32329.1 - 3.1 7.5 5.3 0.63 9.7 0.5 2.0 2 0 0 2 2 2 0 Potassium-channel blocking toxin Acetyltransf_1 PF00583.19 KOO32333.1 - 1.1e-15 57.3 0.2 1.8e-15 56.7 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 KOO32333.1 - 5.6e-09 36.1 0.5 1.8e-08 34.5 0.3 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 KOO32333.1 - 8.7e-08 31.8 0.0 1.7e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.1 KOO32333.1 - 4.2e-07 29.8 0.1 5.8e-07 29.4 0.1 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 KOO32333.1 - 1.9e-06 27.9 0.0 3.1e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 KOO32333.1 - 0.0011 19.1 0.0 0.0012 19.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 KOO32333.1 - 0.011 15.5 0.0 0.016 15.0 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-Nse PF11789.3 KOO32334.1 - 0.00022 20.6 3.0 0.0011 18.4 2.1 2.0 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-MIZ PF02891.15 KOO32334.1 - 0.56 9.7 5.4 0.68 9.4 3.0 1.8 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger mRNA_cap_enzyme PF01331.14 KOO32336.1 - 0.0049 16.5 0.0 0.013 15.1 0.0 1.7 1 1 0 1 1 1 1 mRNA capping enzyme, catalytic domain F1F0-ATPsyn_F PF10791.4 KOO32337.1 - 0.002 18.3 0.1 0.002 18.3 0.1 1.9 2 1 0 2 2 2 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi Peptidase_M14 PF00246.19 KOO32338.1 - 4.2e-23 82.3 0.0 6.3e-23 81.7 0.0 1.4 1 1 0 1 1 1 1 Zinc carboxypeptidase LELP1 PF15042.1 KOO32338.1 - 0.13 12.4 0.6 0.34 11.1 0.4 1.6 1 0 0 1 1 1 0 Late cornified envelope-like proline-rich protein 1 Mg_trans_NIPA PF05653.9 KOO32339.1 - 7.3e-16 57.9 9.2 1.1e-15 57.4 6.4 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA Amidohydro_2 PF04909.9 KOO32340.1 - 2.5e-16 60.0 0.5 7e-12 45.4 0.8 3.5 3 1 0 3 3 3 2 Amidohydrolase TatD_DNase PF01026.16 KOO32340.1 - 0.1 11.7 0.0 1.2 8.2 0.0 2.6 4 0 0 4 4 4 0 TatD related DNase PGC7_Stella PF15549.1 KOO32341.1 - 8.9 6.2 7.0 11 6.0 4.8 1.1 1 0 0 1 1 1 0 PGC7/Stella/Dppa3 domain RhoGEF PF00621.15 KOO32342.1 - 1.3e-27 96.8 0.0 2.2e-27 96.0 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain Tnp_DNA_bind PF14706.1 KOO32342.1 - 0.024 14.3 0.2 0.16 11.7 0.2 2.2 2 0 0 2 2 2 0 Transposase DNA-binding GTP_cyclohydro2 PF00925.15 KOO32346.1 - 2.6e-59 199.2 0.0 3.5e-59 198.8 0.0 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase II Harakiri PF15196.1 KOO32347.1 - 0.059 13.6 3.5 5.8 7.2 0.4 3.1 1 1 1 2 2 2 0 Activator of apoptosis harakiri PH PF00169.24 KOO32351.1 - 0.00049 20.2 0.0 0.0011 19.1 0.0 1.6 1 0 0 1 1 1 1 PH domain Pol_alpha_B_N PF08418.5 KOO32351.1 - 0.025 14.1 1.3 0.032 13.7 0.9 1.2 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal PH_8 PF15409.1 KOO32351.1 - 0.052 13.6 0.0 0.078 13.0 0.0 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain Peptidase_S24 PF00717.18 KOO32352.1 - 5.1e-11 42.0 0.2 8.9e-11 41.2 0.1 1.4 1 0 0 1 1 1 1 Peptidase S24-like DSPc PF00782.15 KOO32353.1 - 7.8e-12 44.9 0.0 1.4e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KOO32353.1 - 0.0056 16.0 0.0 0.0086 15.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.7 KOO32353.1 - 0.078 11.8 0.0 0.099 11.4 0.0 1.1 1 0 0 1 1 1 0 Initiator tRNA phosphoribosyl transferase Suppressor_APC PF11414.3 KOO32354.1 - 0.11 12.2 1.1 0.5 10.1 0.1 2.3 2 0 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein UTP15_C PF09384.5 KOO32355.1 - 6.4e-40 136.2 0.0 9.7e-40 135.6 0.0 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.27 KOO32355.1 - 1.2e-26 91.5 8.8 1.4e-07 31.0 0.1 5.9 6 0 0 6 6 6 5 WD domain, G-beta repeat Glyco_transf_8 PF01501.15 KOO32355.1 - 0.0048 16.2 0.0 0.0081 15.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 Nucleotid_trans PF03407.11 KOO32355.1 - 0.0099 15.6 0.1 0.017 14.9 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Rotamase PF00639.16 KOO32356.1 - 5.8e-17 62.2 1.1 3.4e-16 59.7 0.0 2.4 3 0 0 3 3 3 1 PPIC-type PPIASE domain PUB PF09409.5 KOO32356.1 - 7.7e-15 54.4 0.0 1.4e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 PUB domain Rotamase_3 PF13616.1 KOO32356.1 - 3.1e-14 53.2 0.0 9.7e-14 51.6 0.0 1.8 2 1 0 2 2 2 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 KOO32356.1 - 0.0055 17.3 2.5 0.1 13.2 1.7 2.3 1 1 0 1 1 1 1 PPIC-type PPIASE domain ECM1 PF05782.6 KOO32356.1 - 0.02 13.6 0.0 0.028 13.1 0.0 1.2 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) SF-assemblin PF06705.6 KOO32357.1 - 5.2e-06 25.7 16.9 7.6e-05 21.9 10.4 2.5 1 1 1 2 2 2 2 SF-assemblin/beta giardin Hairy_orange PF07527.8 KOO32357.1 - 0.0091 15.7 0.1 0.021 14.5 0.0 1.7 1 0 0 1 1 1 1 Hairy Orange AAA_13 PF13166.1 KOO32357.1 - 0.2 10.0 3.9 0.27 9.6 2.7 1.2 1 0 0 1 1 1 0 AAA domain Orbi_VP5 PF00901.12 KOO32357.1 - 0.45 8.6 17.8 0.18 10.0 1.6 2.1 1 1 1 2 2 2 0 Orbivirus outer capsid protein VP5 DUF1178 PF06676.6 KOO32357.1 - 0.5 10.5 8.8 1.3 9.1 6.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1178) MerR_2 PF13591.1 KOO32357.1 - 0.62 9.7 4.7 0.099 12.2 0.4 1.9 2 0 0 2 2 2 0 MerR HTH family regulatory protein DUF4047 PF13256.1 KOO32357.1 - 1 9.3 5.8 0.83 9.6 2.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4047) Ank_2 PF12796.2 KOO32358.1 - 0.0092 16.3 0.2 0.03 14.6 0.1 1.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) ECH PF00378.15 KOO32359.1 - 3.9e-40 137.5 1.1 4.2e-40 137.4 0.8 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family ECH_C PF13766.1 KOO32359.1 - 0.00019 21.5 0.1 0.00042 20.4 0.1 1.6 1 0 0 1 1 1 1 2-enoyl-CoA Hydratase C-terminal region LRR_6 PF13516.1 KOO32361.1 - 7.7e-25 84.1 36.0 0.012 15.6 0.2 16.3 18 0 0 18 18 18 8 Leucine Rich repeat LRR_1 PF00560.28 KOO32361.1 - 3.4e-13 47.6 3.7 5.9 7.3 0.1 10.8 12 0 0 12 12 11 2 Leucine Rich Repeat LRR_4 PF12799.2 KOO32361.1 - 3.4e-11 42.4 14.7 0.085 12.5 0.7 7.0 6 1 1 7 7 7 5 Leucine Rich repeats (2 copies) FIBP PF05427.6 KOO32361.1 - 1.8e-06 27.4 0.1 0.94 8.6 0.0 3.1 3 0 0 3 3 3 3 Acidic fibroblast growth factor binding (FIBP) LRR_7 PF13504.1 KOO32361.1 - 1.8e-06 27.1 15.4 7 7.3 0.2 9.7 10 0 0 10 10 9 1 Leucine rich repeat LRR_8 PF13855.1 KOO32361.1 - 0.0013 18.4 18.0 4.4 7.1 0.7 7.5 6 4 0 6 6 6 2 Leucine rich repeat Metal_CEHH PF14455.1 KOO32361.1 - 0.0062 15.9 0.2 6.8 6.0 0.0 3.5 3 1 1 4 4 4 2 Predicted metal binding domain Pyr_redox PF00070.22 KOO32361.1 - 0.0081 16.5 0.0 28 5.2 0.0 3.8 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase SpoU_sub_bind PF08032.7 KOO32361.1 - 0.027 14.6 1.2 1.1e+02 3.0 0.0 4.7 5 0 0 5 5 5 0 RNA 2'-O ribose methyltransferase substrate binding DUF902 PF06001.8 KOO32361.1 - 0.071 13.2 0.2 1.1e+02 3.0 0.0 3.5 3 0 0 3 3 3 0 Domain of Unknown Function (DUF902) KH_2 PF07650.12 KOO32361.1 - 0.11 12.0 0.0 45 3.6 0.0 3.3 3 0 0 3 3 3 0 KH domain Costars PF14705.1 KOO32363.1 - 5e-14 52.0 0.0 7.7e-14 51.4 0.0 1.3 1 0 0 1 1 1 1 Costars Mg-por_mtran_C PF07109.6 KOO32364.1 - 4.6e-32 109.9 0.0 7.7e-32 109.2 0.0 1.4 1 0 0 1 1 1 1 Magnesium-protoporphyrin IX methyltransferase C-terminus Methyltransf_31 PF13847.1 KOO32364.1 - 6.8e-15 54.9 0.0 9.8e-15 54.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO32364.1 - 2.8e-14 53.6 0.2 7e-14 52.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO32364.1 - 9.6e-14 51.4 0.0 1.3e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO32364.1 - 6.5e-12 45.7 0.0 1.2e-11 44.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO32364.1 - 1.9e-10 41.1 0.1 5.2e-10 39.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 KOO32364.1 - 4.4e-10 39.1 0.1 9.2e-10 38.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 KOO32364.1 - 2.6e-09 37.3 0.2 1.7e-08 34.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.15 KOO32364.1 - 1.3e-08 34.3 0.0 2.6e-08 33.2 0.0 1.6 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_26 PF13659.1 KOO32364.1 - 2.9e-06 27.2 0.1 1.5e-05 24.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain UPF0020 PF01170.13 KOO32364.1 - 1.3e-05 24.8 0.1 2.5e-05 23.9 0.1 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_32 PF13679.1 KOO32364.1 - 1.7e-05 24.5 0.0 2.5e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.9 KOO32364.1 - 1.8e-05 24.0 0.0 2.2e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Ubie_methyltran PF01209.13 KOO32364.1 - 9.9e-05 21.5 0.2 0.00019 20.6 0.1 1.5 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family tRNA_U5-meth_tr PF05958.6 KOO32364.1 - 0.00018 20.3 0.0 0.0014 17.3 0.0 2.0 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase PrmA PF06325.8 KOO32364.1 - 0.00035 19.7 0.2 0.0007 18.8 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) FmrO PF07091.6 KOO32364.1 - 0.00059 18.9 0.0 0.00094 18.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA methyltransferase (FmrO) CheR PF01739.13 KOO32364.1 - 0.017 14.4 0.4 4.1 6.6 0.0 2.2 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain NodS PF05401.6 KOO32364.1 - 0.019 14.3 0.0 0.028 13.7 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) DREV PF05219.7 KOO32364.1 - 0.03 13.2 0.0 0.039 12.8 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_15 PF09445.5 KOO32364.1 - 0.077 12.5 0.0 0.17 11.4 0.0 1.6 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase Pro_dh PF01619.13 KOO32365.1 - 1.9e-41 142.1 0.0 3.8e-41 141.0 0.0 1.4 1 1 0 1 1 1 1 Proline dehydrogenase VitK2_biosynth PF02621.9 KOO32365.1 - 0.009 15.2 0.0 0.019 14.1 0.0 1.5 1 0 0 1 1 1 1 Menaquinone biosynthesis PPR_3 PF13812.1 KOO32365.1 - 0.024 14.9 1.2 0.085 13.1 0.0 2.6 2 0 0 2 2 2 0 Pentatricopeptide repeat domain YtxH PF12732.2 KOO32365.1 - 0.2 12.0 0.2 0.2 12.0 0.1 2.2 2 0 0 2 2 2 0 YtxH-like protein PhoD PF09423.5 KOO32366.1 - 2.1e-110 369.3 4.4 2.6e-110 369.0 3.1 1.1 1 0 0 1 1 1 1 PhoD-like phosphatase DUF4229 PF14012.1 KOO32366.1 - 0.1 12.5 0.8 0.32 10.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) E1-E2_ATPase PF00122.15 KOO32369.1 - 2e-50 170.9 3.0 2e-50 170.9 2.0 2.9 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.21 KOO32369.1 - 6e-22 79.1 0.0 2.2e-21 77.3 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO32369.1 - 8e-10 39.2 0.0 1.9e-09 37.9 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 KOO32369.1 - 1.3e-08 34.1 0.0 5.3e-08 32.2 0.0 2.1 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 KOO32369.1 - 0.0014 18.2 0.5 0.0036 16.9 0.2 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF1449 PF07290.6 KOO32369.1 - 0.14 11.4 9.3 0.33 10.2 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1449) Radical_SAM PF04055.16 KOO32371.1 - 1.9e-07 31.4 0.0 2.3e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily Collagen PF01391.13 KOO32372.1 - 0.074 12.6 6.8 0.11 12.0 4.7 1.3 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) MSP1_C PF07462.6 KOO32372.1 - 2.6 6.3 4.3 3.3 6.0 3.0 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus 2OG-FeII_Oxy_3 PF13640.1 KOO32373.1 - 0.075 13.5 0.0 0.19 12.2 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Flavodoxin_2 PF02525.12 KOO32374.1 - 0.0024 17.3 0.1 0.0027 17.2 0.1 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold Ribosomal_60s PF00428.14 KOO32374.1 - 0.97 9.8 4.7 1.2 9.6 3.2 1.1 1 0 0 1 1 1 0 60s Acidic ribosomal protein RRM_1 PF00076.17 KOO32375.1 - 0.0018 17.8 0.0 0.0039 16.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO32375.1 - 0.045 13.7 0.0 0.089 12.7 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) NHL PF01436.16 KOO32376.1 - 1.9e-17 62.1 3.7 3.2e-05 23.6 0.1 5.8 5 0 0 5 5 5 5 NHL repeat PDZ_2 PF13180.1 KOO32376.1 - 0.00019 21.2 0.0 0.00042 20.1 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.19 KOO32376.1 - 0.04 14.0 0.0 0.08 13.1 0.0 1.4 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) Kinesin PF00225.18 KOO32377.1 - 2.3e-94 315.8 0.0 2.7e-94 315.6 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain MR_MLE PF01188.16 KOO32377.1 - 2.6 8.6 5.6 2 8.9 0.7 3.1 3 1 0 3 3 3 0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain ABC1 PF03109.11 KOO32378.1 - 1.5e-24 86.2 0.0 2.4e-24 85.5 0.0 1.3 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 KOO32378.1 - 0.00015 21.5 5.8 0.015 15.0 0.0 3.1 3 1 0 3 3 3 2 Phosphotransferase enzyme family EF-hand_1 PF00036.27 KOO32380.1 - 5.6e-23 78.4 6.3 6.5e-06 25.0 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO32380.1 - 2.8e-20 72.2 5.8 8e-11 41.9 0.1 2.9 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO32380.1 - 6.9e-20 70.4 8.3 1.6e-08 34.0 0.0 4.4 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO32380.1 - 1.8e-17 61.5 5.9 9.4e-05 21.9 0.1 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO32380.1 - 2.3e-17 61.4 6.9 0.00028 20.0 0.0 4.8 4 0 0 4 4 4 4 EF hand zf-C2HC_2 PF13913.1 KOO32380.1 - 1.5e-11 43.6 29.9 3.9e-09 35.9 1.0 4.4 4 0 0 4 4 4 2 zinc-finger of a C2HC-type SPARC_Ca_bdg PF10591.4 KOO32380.1 - 0.00015 21.7 3.7 0.082 12.9 0.0 2.9 3 0 0 3 3 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO32380.1 - 0.00046 19.8 4.6 0.59 9.9 0.0 3.6 2 2 2 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO32380.1 - 0.00065 19.3 3.8 0.43 10.2 0.0 3.6 3 1 1 4 4 4 1 EF hand EF-hand_9 PF14658.1 KOO32380.1 - 0.0037 17.1 0.0 0.58 10.1 0.0 2.8 2 0 0 2 2 2 1 EF-hand domain zf-ribbon_3 PF13248.1 KOO32380.1 - 0.0051 15.9 10.0 0.11 11.7 0.2 3.5 3 0 0 3 3 3 2 zinc-ribbon domain zinc_ribbon_2 PF13240.1 KOO32380.1 - 0.29 10.6 11.2 0.93 9.0 1.0 3.4 3 0 0 3 3 3 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.2 KOO32380.1 - 3.1 7.6 12.2 0.84 9.4 0.6 3.4 4 0 0 4 4 4 0 Transposase zinc-ribbon domain DZR PF12773.2 KOO32380.1 - 8.5 6.2 11.8 25 4.7 5.1 3.3 2 1 0 2 2 2 0 Double zinc ribbon LRR_6 PF13516.1 KOO32381.1 - 1.7e-14 52.2 38.0 0.0028 17.5 0.0 13.3 14 0 0 14 14 14 5 Leucine Rich repeat LRR_1 PF00560.28 KOO32381.1 - 5.6e-11 40.8 14.3 1.3 9.3 0.2 9.9 10 0 0 10 10 10 4 Leucine Rich Repeat LRR_4 PF12799.2 KOO32381.1 - 3e-07 29.8 20.2 1.5 8.4 0.1 8.3 7 1 1 8 8 8 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO32381.1 - 2.1e-05 24.1 9.9 8.8 6.1 0.0 7.1 6 1 0 6 6 6 2 Leucine rich repeat Skp1 PF01466.14 KOO32381.1 - 0.00028 20.8 0.0 0.00068 19.6 0.0 1.6 1 0 0 1 1 1 1 Skp1 family, dimerisation domain LRR_7 PF13504.1 KOO32381.1 - 0.015 15.3 22.5 6.2 7.4 0.4 8.9 10 0 0 10 10 10 0 Leucine rich repeat FIBP PF05427.6 KOO32381.1 - 0.018 14.2 0.0 3.3 6.8 0.0 2.1 2 0 0 2 2 2 0 Acidic fibroblast growth factor binding (FIBP) Skp1_POZ PF03931.10 KOO32381.1 - 0.12 12.4 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain Mito_carr PF00153.22 KOO32382.1 - 1.2e-15 56.9 3.2 2.1e-07 30.5 0.2 4.6 4 1 0 4 4 4 4 Mitochondrial carrier protein zf-DHHC PF01529.15 KOO32383.1 - 8.9e-40 135.9 0.4 1.2e-39 135.4 0.3 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase gpD PF02925.11 KOO32384.1 - 0.12 12.1 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage scaffolding protein D EF-hand_7 PF13499.1 KOO32385.1 - 2.7e-14 53.0 1.7 5.7e-13 48.8 0.2 2.4 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO32385.1 - 2e-12 45.4 3.5 0.00012 21.1 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 KOO32385.1 - 1.2e-10 40.3 5.6 9.5e-05 21.9 0.2 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 KOO32385.1 - 7.2e-07 28.7 2.3 0.00013 21.5 0.1 3.1 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO32385.1 - 9.6e-06 24.7 4.3 0.054 12.8 0.2 2.9 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.4 KOO32385.1 - 0.0061 16.5 0.3 0.01 15.8 0.2 1.4 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region FUSC PF04632.7 KOO32385.1 - 1.2 7.4 2.8 1.5 7.2 2.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Polysacc_deac_1 PF01522.16 KOO32386.1 - 0.056 13.0 0.0 0.065 12.8 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide deacetylase MORN PF02493.15 KOO32387.1 - 2.3e-05 23.8 0.2 0.0079 15.8 0.0 2.8 2 0 0 2 2 2 2 MORN repeat EF-hand_7 PF13499.1 KOO32388.1 - 2.5e-13 49.9 16.7 3.8e-07 30.1 4.7 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO32388.1 - 9.8e-13 46.4 22.1 0.002 17.2 0.3 5.5 4 1 1 5 5 5 4 EF hand C2 PF00168.25 KOO32388.1 - 3.4e-11 42.8 0.1 1.9e-07 30.7 0.0 2.5 2 0 0 2 2 2 2 C2 domain EF-hand_6 PF13405.1 KOO32388.1 - 1.1e-10 40.3 21.7 0.017 14.9 0.7 5.3 3 1 2 5 5 5 4 EF-hand domain EF-hand_5 PF13202.1 KOO32388.1 - 6.3e-09 34.7 16.8 0.0056 15.9 0.1 4.4 4 1 0 4 4 4 3 EF hand XK-related PF09815.4 KOO32388.1 - 0.0029 16.6 0.5 0.0029 16.6 0.3 1.5 2 0 0 2 2 2 1 XK-related protein EF-hand_8 PF13833.1 KOO32388.1 - 0.0033 17.0 15.1 0.061 12.9 0.7 4.2 3 1 1 4 4 4 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO32388.1 - 0.051 13.6 7.1 0.83 9.7 2.3 2.8 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO32388.1 - 0.053 13.2 3.3 0.44 10.3 0.1 2.6 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand Toprim_2 PF13155.1 KOO32388.1 - 1 9.7 4.1 1.6 9.1 0.2 2.7 2 1 0 2 2 2 0 Toprim-like EF-hand_10 PF14788.1 KOO32388.1 - 3.4 7.4 6.9 3.7 7.3 0.1 3.7 2 1 1 3 3 3 0 EF hand IncA PF04156.9 KOO32389.1 - 0.0013 18.4 5.4 0.0013 18.4 3.8 6.3 4 2 2 6 6 6 1 IncA protein DUF4200 PF13863.1 KOO32389.1 - 0.004 17.0 14.2 0.004 17.0 9.8 6.7 6 1 1 7 7 7 3 Domain of unknown function (DUF4200) Pkinase PF00069.20 KOO32390.1 - 3.5e-73 245.9 0.0 4.1e-73 245.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32390.1 - 1e-45 155.8 0.0 1.3e-45 155.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO32390.1 - 2.2e-07 30.1 0.0 1.5e-06 27.4 0.0 1.9 1 1 0 2 2 2 1 Kinase-like Kdo PF06293.9 KOO32390.1 - 0.01 14.9 0.1 0.017 14.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO32390.1 - 0.038 13.7 0.7 0.27 10.9 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.17 KOO32390.1 - 0.059 12.7 0.1 0.14 11.5 0.1 1.7 1 1 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.6 KOO32390.1 - 0.061 12.1 0.0 0.1 11.4 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 FHA PF00498.21 KOO32391.1 - 1.6e-16 60.1 0.1 2.6e-16 59.4 0.1 1.3 1 0 0 1 1 1 1 FHA domain DUF3552 PF12072.3 KOO32391.1 - 0.00082 18.6 3.1 0.00082 18.6 2.2 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3552) DUF4200 PF13863.1 KOO32391.1 - 1.5 8.8 17.1 4.6 7.2 0.3 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) Atg14 PF10186.4 KOO32391.1 - 9.3 5.0 7.7 37 3.1 0.1 2.8 3 0 0 3 3 3 0 UV radiation resistance protein and autophagy-related subunit 14 Ureidogly_hydro PF04115.7 KOO32392.1 - 3.6e-07 29.6 0.0 4.9e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Ureidoglycolate hydrolase AP2 PF00847.15 KOO32393.1 - 5.3e-11 42.5 7.4 1.1e-05 25.4 0.2 6.1 8 0 0 8 8 8 3 AP2 domain zf-RING_2 PF13639.1 KOO32395.1 - 2.3e-06 27.3 10.4 3.3e-06 26.8 7.2 1.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 KOO32395.1 - 0.00026 20.9 9.8 0.0004 20.3 6.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO32395.1 - 0.0013 18.3 8.4 0.0024 17.5 5.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) C1_1 PF00130.17 KOO32395.1 - 0.0039 16.8 5.3 0.0039 16.8 3.7 1.6 1 1 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) GAGA PF09237.6 KOO32395.1 - 0.055 13.0 7.7 0.66 9.6 1.5 2.4 2 0 0 2 2 2 0 GAGA factor PHD PF00628.24 KOO32395.1 - 0.061 13.0 7.3 0.092 12.4 5.1 1.3 1 0 0 1 1 1 0 PHD-finger zf-Apc11 PF12861.2 KOO32395.1 - 0.27 11.0 3.2 0.46 10.3 2.2 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 KOO32395.1 - 3.3 7.8 8.7 6.6 6.9 6.1 1.5 1 1 0 1 1 1 0 RING-H2 zinc finger Ank_2 PF12796.2 KOO32396.1 - 6.5e-32 109.7 1.5 2.5e-21 75.7 0.2 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO32396.1 - 4.8e-31 105.0 1.6 1.9e-09 36.8 0.0 4.3 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.1 KOO32396.1 - 2.7e-22 78.6 0.9 2.3e-08 34.3 0.1 4.1 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO32396.1 - 3.6e-21 73.1 0.5 1.2e-07 31.2 0.0 4.8 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.1 KOO32396.1 - 3.3e-19 68.4 0.9 2.1e-10 40.4 0.1 4.3 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Aminotran_1_2 PF00155.16 KOO32397.1 - 1e-87 294.4 0.0 1.2e-87 294.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.2 KOO32397.1 - 0.019 13.5 0.0 0.054 12.0 0.0 1.7 1 1 0 1 1 1 0 Alanine-glyoxylate amino-transferase EF-hand_7 PF13499.1 KOO32398.1 - 3.9e-19 68.5 0.0 3.7e-08 33.3 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO32398.1 - 3.9e-17 60.5 2.6 0.00013 21.5 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.27 KOO32398.1 - 1.3e-16 58.5 0.1 1.8e-05 23.6 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.1 KOO32398.1 - 1.3e-13 49.6 0.6 0.00077 18.6 0.0 4.1 4 0 0 4 4 4 3 EF hand SPARC_Ca_bdg PF10591.4 KOO32398.1 - 4.8e-05 23.3 0.0 0.079 12.9 0.0 2.4 1 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Josephin PF02099.12 KOO32398.1 - 0.0054 16.3 0.0 1.6 8.3 0.0 2.2 1 1 1 2 2 2 2 Josephin EF-hand_8 PF13833.1 KOO32398.1 - 0.0083 15.7 0.9 15 5.2 0.0 3.8 2 2 2 4 4 4 0 EF-hand domain pair EF-hand_9 PF14658.1 KOO32398.1 - 0.022 14.6 0.0 2.8 7.8 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain PCNA_C PF02747.10 KOO32398.1 - 0.087 12.7 0.0 2.2 8.1 0.0 2.3 2 0 0 2 2 2 0 Proliferating cell nuclear antigen, C-terminal domain SAP PF02037.22 KOO32398.1 - 0.12 11.9 3.7 8.4 6.0 0.0 3.0 3 0 0 3 3 3 0 SAP domain Haemagg_act PF05860.8 KOO32398.1 - 0.15 11.8 0.2 47 3.7 0.1 3.0 3 0 0 3 3 3 0 haemagglutination activity domain DUF2526 PF10735.4 KOO32398.1 - 0.16 11.9 0.1 29 4.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2526) DnaJ PF00226.26 KOO32399.1 - 2.4e-05 23.9 0.0 6.6e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain CAF-1_p150 PF11600.3 KOO32399.1 - 0.025 13.9 17.2 0.042 13.2 11.9 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal IncA PF04156.9 KOO32399.1 - 0.038 13.5 2.4 0.057 13.0 1.7 1.2 1 0 0 1 1 1 0 IncA protein TFIIA PF03153.8 KOO32399.1 - 0.76 9.6 17.0 1.1 9.0 11.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1423 PF07227.6 KOO32399.1 - 2.1 6.8 7.3 3.4 6.2 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1423) JmjC PF02373.17 KOO32400.1 - 1.9e-30 105.4 0.0 2.9e-30 104.8 0.0 1.3 1 0 0 1 1 1 1 JmjC domain, hydroxylase Baculo_PEP_C PF04513.7 KOO32401.1 - 0.25 11.1 2.1 3.8 7.3 0.1 2.7 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Exonuc_VII_L PF02601.10 KOO32401.1 - 1.1 8.3 6.8 6.2 5.9 4.7 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit Potyvirid-P3 PF13608.1 KOO32401.1 - 1.3 8.0 8.2 1.2 8.2 4.3 1.7 1 1 1 2 2 2 0 Protein P3 of Potyviral polyprotein LRR_5 PF13306.1 KOO32402.1 - 2.4e-83 276.2 5.6 4.7e-44 149.1 0.8 2.3 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO32402.1 - 4.8e-21 74.2 0.0 0.00016 21.3 0.0 5.3 1 1 7 8 8 8 7 Leucine rich repeat NACHT PF05729.7 KOO32404.1 - 1e-07 31.7 0.3 2.4e-07 30.5 0.2 1.5 1 1 0 1 1 1 1 NACHT domain NB-ARC PF00931.17 KOO32404.1 - 0.052 12.3 0.0 0.11 11.3 0.0 1.5 1 1 0 1 1 1 0 NB-ARC domain AAA_16 PF13191.1 KOO32404.1 - 0.84 9.5 4.8 19 5.1 3.4 2.6 1 1 0 1 1 1 0 AAA ATPase domain LRR_6 PF13516.1 KOO32405.1 - 2.9e-13 48.3 1.3 0.21 11.7 0.0 7.5 7 0 0 7 7 7 4 Leucine Rich repeat LRR_1 PF00560.28 KOO32405.1 - 3.2e-05 23.3 0.3 12 6.3 0.2 6.0 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_4 PF12799.2 KOO32405.1 - 0.0096 15.5 3.7 4.4 7.0 0.0 4.4 4 1 1 5 5 5 2 Leucine Rich repeats (2 copies) Profilin PF00235.14 KOO32405.1 - 0.063 13.3 0.1 1.3 9.1 0.0 2.3 2 0 0 2 2 2 0 Profilin LRR_7 PF13504.1 KOO32405.1 - 0.98 9.8 7.2 52 4.7 0.0 4.7 5 0 0 5 5 5 0 Leucine rich repeat HALZ PF02183.13 KOO32406.1 - 0.00099 18.7 4.4 0.2 11.3 0.3 2.8 1 1 1 2 2 2 2 Homeobox associated leucine zipper PIF1 PF05970.9 KOO32407.1 - 8.5e-23 80.8 0.0 1e-09 37.8 0.0 3.2 2 1 1 3 3 3 3 PIF1-like helicase AAA_30 PF13604.1 KOO32407.1 - 1e-12 48.0 0.0 5.2e-12 45.7 0.0 2.2 3 0 0 3 3 2 1 AAA domain AAA_11 PF13086.1 KOO32407.1 - 3.3e-10 39.9 0.0 0.00032 20.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 KOO32407.1 - 7.3e-08 32.0 0.2 2.3e-07 30.4 0.1 1.9 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 KOO32407.1 - 4.2e-06 26.9 0.0 1.1e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain zf-CCHC PF00098.18 KOO32407.1 - 5.6e-06 26.0 6.1 5.6e-06 26.0 4.2 3.2 3 0 0 3 3 3 1 Zinc knuckle Herpes_Helicase PF02689.9 KOO32407.1 - 7.8e-06 23.9 0.0 1.6e-05 22.8 0.0 1.4 2 0 0 2 2 2 1 Helicase UvrD_C_2 PF13538.1 KOO32407.1 - 1.5e-05 25.0 0.1 3.9e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Mg_chelatase PF01078.16 KOO32407.1 - 0.00072 18.7 0.2 0.0017 17.5 0.0 1.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 KOO32407.1 - 0.0013 18.4 0.0 0.0033 17.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.1 KOO32407.1 - 0.0019 18.1 0.1 0.0049 16.8 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOO32407.1 - 0.0038 17.2 0.9 0.018 15.0 0.0 2.7 3 0 0 3 3 3 1 AAA ATPase domain DUF2075 PF09848.4 KOO32407.1 - 0.0084 15.1 0.0 0.086 11.7 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.1 KOO32407.1 - 0.0092 16.2 0.0 0.022 15.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.10 KOO32407.1 - 0.024 14.3 0.1 0.056 13.1 0.0 1.7 1 0 0 1 1 1 0 NTPase AAA PF00004.24 KOO32407.1 - 0.031 14.4 0.0 0.25 11.5 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DEAD PF00270.24 KOO32407.1 - 0.052 13.0 0.0 5.5 6.4 0.0 2.3 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_25 PF13481.1 KOO32407.1 - 0.073 12.4 0.0 0.18 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 KOO32407.1 - 0.095 12.8 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_10 PF12846.2 KOO32407.1 - 0.1 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain UvrD-helicase PF00580.16 KOO32407.1 - 0.12 11.6 0.0 0.25 10.5 0.0 1.5 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain PhoH PF02562.11 KOO32407.1 - 0.15 11.3 0.1 0.39 9.9 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein DUF563 PF04577.9 KOO32408.1 - 9.6e-06 25.6 0.0 2e-05 24.6 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF563) ART PF01129.13 KOO32409.1 - 0.00086 18.4 0.0 0.0045 16.1 0.0 2.0 1 1 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase CHAP PF05257.11 KOO32409.1 - 0.095 12.3 0.1 0.19 11.3 0.1 1.4 1 0 0 1 1 1 0 CHAP domain ADPrib_exo_Tox PF03496.9 KOO32409.1 - 0.12 11.6 0.0 1.5 7.9 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosyltransferase exoenzyme Bromodomain PF00439.20 KOO32410.1 - 2.4e-20 72.2 0.0 3.8e-20 71.5 0.0 1.3 1 0 0 1 1 1 1 Bromodomain Abi_HHR PF07815.9 KOO32410.1 - 0.02 15.0 0.0 0.041 13.9 0.0 1.5 1 0 0 1 1 1 0 Abl-interactor HHR Epimerase PF01370.16 KOO32411.1 - 3.2e-15 56.2 0.1 4.6e-15 55.6 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Epimerase_Csub PF13950.1 KOO32411.1 - 4.9e-06 26.3 0.0 1.4e-05 24.9 0.0 1.7 2 0 0 2 2 2 1 UDP-glucose 4-epimerase C-term subunit Epimerase PF01370.16 KOO32412.1 - 2.9e-43 148.0 0.1 3.2e-43 147.8 0.1 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 KOO32412.1 - 1.4e-09 37.2 0.0 1.9e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 KOO32412.1 - 0.01 14.7 0.0 0.014 14.2 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein NmrA PF05368.8 KOO32412.1 - 0.036 13.3 0.0 0.047 12.9 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family NAD_binding_10 PF13460.1 KOO32412.1 - 0.049 13.6 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 NADH(P)-binding adh_short PF00106.20 KOO32412.1 - 0.077 12.8 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase TTL PF03133.10 KOO32413.1 - 2.7e-54 184.1 0.0 9.8e-36 123.1 0.0 2.1 2 0 0 2 2 2 2 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 KOO32413.1 - 4.6e-06 25.6 0.0 2.7e-05 23.1 0.0 2.1 2 1 0 2 2 2 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.1 KOO32413.1 - 6.7e-06 25.3 0.0 0.088 11.8 0.0 2.3 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATP-grasp_4 PF13535.1 KOO32413.1 - 0.00043 20.0 0.0 0.011 15.4 0.0 2.7 3 0 0 3 3 3 1 ATP-grasp domain ATP-grasp_3 PF02655.9 KOO32413.1 - 0.0035 17.2 0.0 0.11 12.3 0.0 2.3 2 0 0 2 2 2 1 ATP-grasp domain RimK PF08443.6 KOO32413.1 - 0.0051 16.2 0.0 0.3 10.5 0.0 2.2 2 0 0 2 2 2 1 RimK-like ATP-grasp domain ATPgrasp_Ter PF15632.1 KOO32413.1 - 0.081 11.6 0.0 8.5 5.0 0.0 2.2 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon LRR_6 PF13516.1 KOO32414.1 - 9e-34 111.7 9.3 0.00013 21.6 0.0 7.7 8 0 0 8 8 8 7 Leucine Rich repeat LRR_1 PF00560.28 KOO32414.1 - 3.5e-07 29.3 0.0 12 6.3 0.1 6.5 7 0 0 7 7 7 1 Leucine Rich Repeat LRR_4 PF12799.2 KOO32414.1 - 6.7e-07 28.7 4.9 0.72 9.5 1.4 5.2 4 3 1 5 5 5 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO32414.1 - 0.00023 20.8 6.7 0.55 10.0 0.0 5.1 3 2 2 5 5 5 1 Leucine rich repeat LRR_7 PF13504.1 KOO32414.1 - 0.00028 20.5 7.3 31 5.4 0.0 6.4 8 1 0 8 8 8 0 Leucine rich repeat CbiG_N PF11760.3 KOO32414.1 - 0.017 14.8 10.7 6.6 6.5 0.0 5.1 3 1 2 5 5 5 0 Cobalamin synthesis G N-terminal Phage_integ_N PF09003.5 KOO32414.1 - 0.11 12.2 9.1 3.3 7.4 0.0 4.4 5 0 0 5 5 5 0 Bacteriophage lambda integrase, N-terminal domain YycC PF14174.1 KOO32414.1 - 0.13 11.9 0.0 36 4.1 0.0 4.1 5 0 0 5 5 5 0 YycC-like protein HOASN PF14515.1 KOO32414.1 - 0.96 9.8 16.1 1.6 9.1 1.2 4.6 2 2 4 6 6 6 0 Haem-oxygenase-associated N-terminal helices SpoU_sub_bind PF08032.7 KOO32414.1 - 1.1 9.4 4.2 14 5.9 0.1 3.9 4 1 0 4 4 4 0 RNA 2'-O ribose methyltransferase substrate binding MFS_1 PF07690.11 KOO32415.1 - 3.6e-05 22.6 7.4 6.1e-05 21.8 5.1 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily SNF2_N PF00176.18 KOO32417.1 - 3.9e-56 190.0 0.0 4.9e-56 189.7 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOO32417.1 - 2.6e-12 46.4 0.1 5.8e-12 45.2 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOO32417.1 - 4.4e-06 26.2 0.0 7.5e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.3 KOO32417.1 - 0.0013 17.6 0.0 0.047 12.4 0.0 2.3 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.10 KOO32417.1 - 0.0016 18.3 0.0 0.0069 16.2 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit YL1 PF05764.8 KOO32418.1 - 0.092 12.3 1.1 0.13 11.8 0.8 1.2 1 0 0 1 1 1 0 YL1 nuclear protein ERO1 PF04137.10 KOO32419.1 - 1.6e-79 267.5 0.0 9.1e-49 166.3 0.0 2.1 1 1 1 2 2 2 2 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) Fer4_18 PF13746.1 KOO32419.1 - 0.049 14.0 0.5 0.13 12.6 0.3 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain LRR_6 PF13516.1 KOO32420.1 - 3.9e-19 66.5 22.4 0.046 13.7 0.3 12.5 13 0 0 13 13 13 5 Leucine Rich repeat EF-hand_1 PF00036.27 KOO32420.1 - 2.9e-09 35.5 0.1 0.00032 19.7 0.0 2.8 2 0 0 2 2 2 2 EF hand LRR_1 PF00560.28 KOO32420.1 - 4.6e-09 35.0 3.6 9 6.7 0.0 9.2 12 0 0 12 12 12 2 Leucine Rich Repeat EF-hand_7 PF13499.1 KOO32420.1 - 3.2e-08 33.5 0.2 1e-07 31.9 0.1 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO32420.1 - 2.1e-06 27.0 1.2 0.0085 15.8 0.0 3.8 3 1 1 4 4 4 2 EF-hand domain LRR_4 PF12799.2 KOO32420.1 - 2.6e-06 26.9 10.5 0.1 12.2 0.0 7.1 7 1 0 7 7 7 1 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO32420.1 - 0.00059 19.6 11.6 13 6.5 0.1 7.7 7 0 0 7 7 7 1 Leucine rich repeat EF-hand_8 PF13833.1 KOO32420.1 - 0.0096 15.5 0.3 0.063 12.9 0.1 3.2 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO32420.1 - 0.025 13.9 4.6 0.94 8.9 0.0 3.0 3 0 0 3 3 3 0 EF hand SPARC_Ca_bdg PF10591.4 KOO32420.1 - 0.036 14.0 0.2 0.16 12.0 0.0 2.0 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region FAM219A PF15260.1 KOO32421.1 - 4e-07 30.4 0.1 4.8e-07 30.1 0.1 1.2 1 0 0 1 1 1 1 Protein family FAM219A EF-hand_1 PF00036.27 KOO32422.1 - 4.1e-13 47.5 2.0 1.8e-05 23.7 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO32422.1 - 1.1e-12 46.6 0.4 2.6e-06 26.8 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO32422.1 - 1.4e-11 44.3 0.4 2.2e-11 43.7 0.3 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO32422.1 - 6.4e-11 41.7 0.5 2.8e-06 26.8 0.3 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO32422.1 - 2e-10 39.5 2.0 0.0001 21.4 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.2 KOO32422.1 - 0.00026 20.6 0.1 0.00065 19.4 0.1 1.6 1 1 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO32422.1 - 0.00033 20.5 0.0 0.00053 19.8 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_10 PF14788.1 KOO32422.1 - 0.0054 16.3 0.2 0.012 15.2 0.1 1.6 1 1 1 2 2 2 1 EF hand DUF1133 PF06576.6 KOO32422.1 - 0.014 14.5 0.0 0.018 14.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1133) PFU PF09070.6 KOO32422.1 - 0.029 14.3 0.0 0.037 14.0 0.0 1.2 1 0 0 1 1 1 0 PFU (PLAA family ubiquitin binding) SPARC_Ca_bdg PF10591.4 KOO32422.1 - 0.16 12.0 0.0 0.24 11.4 0.0 1.4 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region gag-asp_proteas PF13975.1 KOO32423.1 - 0.02 14.7 0.5 0.15 11.8 0.0 2.6 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease NAD_synthase PF02540.12 KOO32426.1 - 7e-24 84.0 0.0 2.3e-23 82.3 0.0 1.8 1 1 0 1 1 1 1 NAD synthase CN_hydrolase PF00795.17 KOO32426.1 - 1.6e-19 70.0 0.0 2.8e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DUF1174 PF06671.6 KOO32426.1 - 0.15 11.7 2.3 0.4 10.3 1.6 1.7 1 0 0 1 1 1 0 Repeat of unknown function (DUF1174) GLTP PF08718.6 KOO32427.1 - 5.8e-18 65.3 0.0 9.8e-18 64.6 0.0 1.3 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) EF-hand_1 PF00036.27 KOO32427.1 - 8.4e-05 21.6 0.7 0.00022 20.2 0.5 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO32427.1 - 9e-05 22.0 0.1 0.00024 20.7 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.1 KOO32427.1 - 0.00071 18.8 0.3 0.0018 17.5 0.2 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO32427.1 - 0.01 15.9 0.1 0.025 14.7 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair SseC PF04888.7 KOO32427.1 - 0.025 13.9 6.7 0.041 13.1 4.7 1.3 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Lumazine_bd PF12870.2 KOO32427.1 - 0.1 12.6 0.2 2 8.4 0.0 2.5 2 0 0 2 2 2 0 Lumazine-binding domain PHB_acc_N PF07879.6 KOO32428.1 - 0.027 14.1 0.8 0.049 13.3 0.5 1.3 1 0 0 1 1 1 0 PHB/PHA accumulation regulator DNA-binding domain Arm PF00514.18 KOO32429.1 - 1.1e-16 59.9 4.0 1.4e-05 24.7 0.1 3.5 2 1 1 3 3 3 3 Armadillo/beta-catenin-like repeat Nucleotid_trans PF03407.11 KOO32429.1 - 0.056 13.2 0.0 0.17 11.6 0.0 1.6 1 1 0 1 1 1 0 Nucleotide-diphospho-sugar transferase MORN PF02493.15 KOO32430.1 - 1.6e-29 99.8 37.0 2.2e-06 27.0 0.2 8.8 9 0 0 9 9 9 8 MORN repeat Pox_A12 PF04651.8 KOO32431.1 - 0.014 15.5 0.6 0.014 15.5 0.5 2.2 2 0 0 2 2 2 0 Poxvirus A12 protein VHS PF00790.14 KOO32431.1 - 0.093 12.3 1.5 0.42 10.2 1.1 2.0 1 1 0 1 1 1 0 VHS domain UBA PF00627.26 KOO32433.1 - 0.018 14.8 0.1 0.072 12.9 0.0 2.0 1 1 0 1 1 1 0 UBA/TS-N domain RuvA_C PF07499.8 KOO32433.1 - 0.077 13.1 0.4 0.29 11.3 0.1 1.9 2 0 0 2 2 2 0 RuvA, C-terminal domain PAN_4 PF14295.1 KOO32433.1 - 0.38 10.5 3.2 1.8 8.2 2.2 1.9 1 1 0 1 1 1 0 PAN domain DUF2336 PF10098.4 KOO32434.1 - 0.081 12.1 1.4 0.12 11.6 0.8 1.4 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2336) DUF4533 PF15047.1 KOO32434.1 - 0.12 11.7 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4533) DUF2453 PF10507.4 KOO32436.1 - 6.2e-33 112.9 6.8 9.5e-33 112.3 4.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2453) GAF PF01590.21 KOO32436.1 - 7.2e-16 58.6 0.0 1.5e-11 44.6 0.0 2.6 2 1 0 2 2 2 2 GAF domain GAF_2 PF13185.1 KOO32436.1 - 1.2e-10 42.1 0.0 2.7e-07 31.1 0.0 2.6 1 1 0 1 1 1 1 GAF domain GAF_3 PF13492.1 KOO32436.1 - 2.1e-09 37.5 0.0 7.9e-09 35.6 0.0 2.0 1 1 0 1 1 1 1 GAF domain EF-hand_9 PF14658.1 KOO32436.1 - 3.3e-05 23.7 0.0 6.3e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.27 KOO32436.1 - 6e-05 22.0 0.1 0.0018 17.4 0.0 2.8 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.1 KOO32436.1 - 8.8e-05 22.0 0.0 0.00026 20.6 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 KOO32436.1 - 0.0049 16.9 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO32436.1 - 0.013 14.7 0.0 0.048 13.0 0.0 2.0 1 0 0 1 1 1 0 EF hand EF-hand_8 PF13833.1 KOO32436.1 - 0.058 13.0 0.1 4.8 6.8 0.0 3.0 2 1 0 2 2 2 0 EF-hand domain pair Romo1 PF10247.4 KOO32436.1 - 0.15 12.2 1.9 1.4 9.2 0.0 2.5 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 VPS9 PF02204.13 KOO32437.1 - 5.1e-19 68.2 0.0 7.9e-19 67.6 0.0 1.3 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain LRR_6 PF13516.1 KOO32438.1 - 8.2e-08 31.5 0.1 0.25 11.5 0.0 6.9 8 0 0 8 8 8 1 Leucine Rich repeat Skp1 PF01466.14 KOO32438.1 - 7.3e-05 22.7 0.0 0.00017 21.5 0.0 1.6 1 0 0 1 1 1 1 Skp1 family, dimerisation domain LRR_1 PF00560.28 KOO32438.1 - 0.0014 18.3 0.1 32 5.0 0.0 5.4 6 0 0 6 6 6 1 Leucine Rich Repeat DUF3754 PF12576.3 KOO32441.1 - 6.2e-09 35.6 0.0 9.1e-09 35.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3754) Ion_trans PF00520.26 KOO32442.1 - 3.1e-07 29.8 12.6 2.4e-06 26.9 8.7 2.5 1 1 0 1 1 1 1 Ion transport protein Rtf2 PF04641.7 KOO32444.1 - 4.9e-15 55.4 1.6 5e-08 32.4 0.1 2.6 2 2 0 2 2 2 2 Rtf2 RING-finger U-box PF04564.10 KOO32444.1 - 8.1e-06 25.7 0.3 0.23 11.4 0.0 3.1 3 1 0 3 3 3 2 U-box domain zf-Nse PF11789.3 KOO32444.1 - 0.0085 15.5 0.1 1.4 8.4 0.0 3.3 3 0 0 3 3 3 1 Zinc-finger of the MIZ type in Nse subunit DUF3134 PF11332.3 KOO32446.1 - 0.076 13.1 1.3 0.14 12.3 0.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3134) zf-DHHC PF01529.15 KOO32447.1 - 4.5e-32 110.8 0.2 6.1e-32 110.3 0.2 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase LRR19-TM PF15176.1 KOO32447.1 - 0.14 11.8 0.5 0.38 10.4 0.4 1.8 1 1 0 1 1 1 0 Leucine-rich repeat family 19 TM domain DZR PF12773.2 KOO32447.1 - 1.2 8.9 7.6 0.27 11.0 2.9 1.7 2 0 0 2 2 2 0 Double zinc ribbon TPR_11 PF13414.1 KOO32448.1 - 6.1e-06 25.7 1.6 1.2e-05 24.8 1.1 1.4 1 0 0 1 1 1 1 TPR repeat EF-hand_5 PF13202.1 KOO32448.1 - 0.00079 18.6 1.0 0.0017 17.5 0.7 1.5 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KOO32448.1 - 0.0014 17.7 0.1 0.0029 16.8 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO32448.1 - 0.01 15.9 0.0 0.022 14.8 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.1 KOO32448.1 - 0.034 14.0 0.1 0.08 12.8 0.1 1.6 1 0 0 1 1 1 0 EF-hand domain BTAD PF03704.12 KOO32448.1 - 0.056 13.7 1.3 0.46 10.7 0.1 2.2 1 1 1 2 2 2 0 Bacterial transcriptional activator domain DUF1707 PF08044.6 KOO32448.1 - 0.11 12.2 1.0 0.22 11.2 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1707) TPR_2 PF07719.12 KOO32448.1 - 1.5 8.9 4.1 3.7 7.7 1.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat SpoU_methylase PF00588.14 KOO32449.1 - 9.8e-21 74.1 0.0 5.1e-19 68.5 0.0 2.7 1 1 0 1 1 1 1 SpoU rRNA Methylase family Ank_2 PF12796.2 KOO32450.1 - 9.2e-24 83.6 0.4 3.3e-12 46.5 0.0 5.0 3 2 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO32450.1 - 1.5e-18 66.7 0.0 1.6e-06 28.4 0.0 4.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO32450.1 - 5.3e-16 57.5 0.2 3.1e-05 23.5 0.0 5.8 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.1 KOO32450.1 - 2.6e-14 52.9 3.5 0.012 15.8 0.0 6.6 5 2 1 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO32450.1 - 3.1e-13 48.5 0.8 0.00095 19.1 0.0 6.0 6 1 1 7 7 7 2 Ankyrin repeat LRR_8 PF13855.1 KOO32451.1 - 1.9e-05 24.3 0.1 4e-05 23.2 0.1 1.6 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.2 KOO32451.1 - 0.003 17.1 0.4 0.051 13.2 0.0 2.1 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO32451.1 - 0.015 15.2 0.5 0.18 11.9 0.0 3.0 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_6 PF13516.1 KOO32451.1 - 0.044 13.8 0.0 0.83 9.9 0.0 2.9 3 0 0 3 3 3 0 Leucine Rich repeat RRM_6 PF14259.1 KOO32451.1 - 0.053 13.4 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF445 PF04286.7 KOO32452.1 - 0.31 10.5 8.2 0.59 9.5 5.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF445) V_ATPase_I PF01496.14 KOO32452.1 - 1.1 7.0 8.7 1.6 6.4 6.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Exonuc_VII_L PF02601.10 KOO32452.1 - 2.1 7.4 9.3 3.6 6.6 6.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit IncA PF04156.9 KOO32452.1 - 6.5 6.3 25.7 0.16 11.5 13.2 1.7 2 0 0 2 2 2 0 IncA protein OmpH PF03938.9 KOO32452.1 - 8.3 6.3 33.5 61 3.5 23.3 2.2 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4139 PF13598.1 KOO32453.1 - 1.2 8.3 3.8 1.5 8.0 2.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4139) Ank_2 PF12796.2 KOO32454.1 - 2.7e-47 159.0 26.1 4.8e-14 52.4 1.0 6.9 3 1 5 8 8 8 6 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO32454.1 - 4.5e-33 113.0 4.8 5.1e-11 42.7 0.2 7.3 4 2 4 8 8 8 8 Ankyrin repeats (many copies) Ank PF00023.25 KOO32454.1 - 1.9e-30 103.1 11.0 0.00012 21.7 0.0 11.4 11 1 1 12 12 12 7 Ankyrin repeat Ank_5 PF13857.1 KOO32454.1 - 4.3e-26 90.3 13.8 2.9e-07 30.5 0.4 9.1 5 2 4 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO32454.1 - 1.5e-22 77.4 9.4 0.0012 18.8 0.0 10.4 11 0 0 11 11 11 5 Ankyrin repeat ADPrib_exo_Tox PF03496.9 KOO32454.1 - 1.1e-05 24.7 0.5 0.00047 19.4 0.4 2.8 2 1 0 2 2 2 1 ADP-ribosyltransferase exoenzyme ART PF01129.13 KOO32454.1 - 2.6e-05 23.4 0.0 0.00013 21.1 0.0 2.1 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase NUDIX PF00293.23 KOO32454.1 - 0.00057 19.5 0.3 0.0055 16.3 0.0 2.6 3 0 0 3 3 3 1 NUDIX domain RVT_2 PF07727.9 KOO32455.1 - 0.00033 19.7 0.0 0.0015 17.5 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) 2OG-FeII_Oxy_2 PF13532.1 KOO32457.1 - 0.00019 21.3 0.0 0.00034 20.4 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO32457.1 - 0.13 11.9 0.0 7 6.3 0.0 2.3 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily WHEP-TRS PF00458.15 KOO32458.1 - 2.4e-06 27.1 6.2 6.2e-06 25.7 4.3 1.8 1 1 0 1 1 1 1 WHEP-TRS domain Sel1 PF08238.7 KOO32459.1 - 1.6e-296 950.2 342.2 7.2e-09 36.0 1.5 40.2 40 0 0 40 40 40 40 Sel1 repeat DUF4521 PF15021.1 KOO32459.1 - 0.0026 17.3 1.3 12 5.4 0.0 5.4 4 1 1 5 5 5 1 Protein of unknown function (DUF4521) GSP_synth PF03738.9 KOO32459.1 - 0.01 16.0 13.9 88 3.4 0.0 10.0 10 3 3 14 14 14 0 Glutathionylspermidine synthase preATP-grasp Fe_dep_repress PF01325.14 KOO32459.1 - 0.013 15.4 0.2 15 5.6 0.0 6.0 9 0 0 9 9 9 0 Iron dependent repressor, N-terminal DNA binding domain Rieske_2 PF13806.1 KOO32459.1 - 0.014 15.1 7.3 26 4.5 0.0 7.7 8 1 1 9 9 9 0 Rieske-like [2Fe-2S] domain GlgS PF08971.6 KOO32459.1 - 0.027 14.4 22.6 71 3.4 0.0 11.4 11 0 0 11 11 11 0 Glycogen synthesis protein PgaD PF13994.1 KOO32459.1 - 1.4 8.4 27.8 3.8 7.0 0.1 10.0 7 3 4 12 12 12 0 PgaD-like protein 7TM_GPCR_Srw PF10324.4 KOO32460.1 - 0.59 9.2 3.2 34 3.4 0.0 3.1 1 1 3 4 4 4 0 Serpentine type 7TM GPCR chemoreceptor Srw DUF3425 PF11905.3 KOO32460.1 - 0.93 9.3 5.1 5.7 6.8 0.0 3.0 2 1 2 4 4 4 0 Domain of unknown function (DUF3425) Na_Ca_ex PF01699.19 KOO32461.1 - 2.5e-36 124.3 16.8 2.9e-23 82.0 3.9 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein LRR_5 PF13306.1 KOO32462.1 - 1.7e-19 69.8 0.0 2.3e-19 69.3 0.0 1.1 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO32462.1 - 1.7e-05 24.4 0.0 0.028 14.1 0.0 3.4 2 1 1 3 3 3 2 Leucine rich repeat DUF4231 PF14015.1 KOO32463.1 - 3.1e-12 46.4 3.1 5.8e-10 39.1 0.1 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF4231) 4HB_MCP_1 PF12729.2 KOO32463.1 - 0.098 11.9 2.8 26 4.1 0.0 3.3 3 0 0 3 3 3 0 Four helix bundle sensory module for signal transduction Choline_transpo PF04515.7 KOO32464.1 - 1.3e-62 211.5 34.2 1.3e-62 211.5 23.7 2.0 3 0 0 3 3 3 1 Plasma-membrane choline transporter EF-hand_8 PF13833.1 KOO32465.1 - 1.2e-27 95.3 3.0 1.2e-06 27.9 0.0 4.4 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.27 KOO32465.1 - 1.7e-27 92.6 4.9 9.5e-06 24.5 0.5 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO32465.1 - 3.2e-23 81.6 0.2 3.3e-10 39.9 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO32465.1 - 1.2e-22 77.6 0.8 0.00023 20.7 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO32465.1 - 4.5e-21 73.1 10.9 7.5e-05 21.8 0.5 4.7 4 1 1 5 5 5 4 EF hand EF-hand_4 PF12763.2 KOO32465.1 - 1.4e-14 53.6 0.2 0.014 15.1 0.0 4.2 3 1 1 4 4 4 4 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO32465.1 - 2.4e-07 30.2 0.8 1.3 8.7 0.0 4.2 4 0 0 4 4 4 3 EF hand SPARC_Ca_bdg PF10591.4 KOO32465.1 - 0.0096 15.9 0.0 3.5 7.6 0.0 3.4 3 1 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region DUF3459 PF11941.3 KOO32465.1 - 0.47 10.6 7.1 1.4 9.1 0.1 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF3459) RVT_2 PF07727.9 KOO32466.1 - 2.9e-10 39.5 0.1 1.9e-09 36.8 0.1 2.3 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KOO32466.1 - 2.9e-10 40.2 0.0 1.1e-09 38.4 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain gag_pre-integrs PF13976.1 KOO32466.1 - 0.0021 17.6 0.2 0.0048 16.4 0.1 1.5 1 0 0 1 1 1 1 GAG-pre-integrase domain CaATP_NAI PF12515.3 KOO32468.1 - 0.066 12.7 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 Ca2+-ATPase N terminal autoinhibitory domain Pkinase_Tyr PF07714.12 KOO32469.1 - 4e-39 134.2 0.0 4e-18 65.4 0.0 3.2 3 1 0 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.20 KOO32469.1 - 6.3e-37 127.1 0.0 7.2e-36 123.6 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.18 KOO32469.1 - 0.0034 17.1 0.8 0.014 15.1 0.0 2.2 2 1 0 2 2 2 1 Phosphotransferase enzyme family PDZ PF00595.19 KOO32471.1 - 0.02 15.0 0.0 0.047 13.8 0.0 1.6 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) RVT_2 PF07727.9 KOO32472.1 - 0.00024 20.1 0.0 0.0006 18.8 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) PROCN PF08083.6 KOO32473.1 - 2e-221 734.6 1.8 3.4e-221 733.9 1.3 1.4 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.3 KOO32473.1 - 1.1e-126 420.8 0.5 1.8e-126 420.1 0.3 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.4 KOO32473.1 - 1.6e-94 313.5 1.4 3.1e-94 312.6 1.0 1.5 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.6 KOO32473.1 - 1e-81 271.9 2.1 2.4e-81 270.7 1.5 1.7 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.4 KOO32473.1 - 8e-69 229.4 0.1 1.5e-68 228.6 0.1 1.4 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.6 KOO32473.1 - 9.1e-50 167.5 0.1 2.2e-49 166.3 0.1 1.7 1 0 0 1 1 1 1 PROCT (NUC072) domain RRM_4 PF10598.4 KOO32473.1 - 2.6e-43 145.7 0.1 7.5e-43 144.3 0.1 1.9 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 JAB PF01398.16 KOO32473.1 - 2.2e-08 33.8 0.0 5.5e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DUF3584 PF12128.3 KOO32474.1 - 0.095 10.0 12.4 0.11 9.7 8.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) PolyA_pol PF01743.15 KOO32474.1 - 1.1 9.4 4.9 0.76 9.9 1.1 2.0 1 1 1 2 2 2 0 Poly A polymerase head domain DUF572 PF04502.8 KOO32474.1 - 1.4 8.1 6.9 1.8 7.6 4.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) HlyD PF00529.15 KOO32474.1 - 2.4 7.3 19.9 3.1 6.9 13.8 1.2 1 0 0 1 1 1 0 HlyD family secretion protein Fez1 PF06818.10 KOO32474.1 - 2.9 7.8 17.0 0.91 9.5 3.2 1.9 1 1 0 1 1 1 0 Fez1 DUF2040 PF09745.4 KOO32474.1 - 5.3 6.8 9.0 7.9 6.3 6.3 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 55 (DUF2040) Nucleotid_trans PF03407.11 KOO32476.1 - 6e-21 75.1 0.0 1.1e-20 74.3 0.0 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase GBP PF02263.14 KOO32478.1 - 5e-17 61.8 0.0 8.2e-17 61.1 0.0 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Transpeptidase PF00905.17 KOO32478.1 - 0.079 11.9 0.1 0.13 11.2 0.1 1.3 1 0 0 1 1 1 0 Penicillin binding protein transpeptidase domain Bactofilin PF04519.8 KOO32479.1 - 0.13 12.2 4.0 0.13 12.2 0.7 2.3 2 0 0 2 2 2 0 Polymer-forming cytoskeletal Trehalase PF01204.13 KOO32481.1 - 0.089 11.4 0.0 0.18 10.3 0.0 1.4 1 0 0 1 1 1 0 Trehalase Spermine_synth PF01564.12 KOO32482.1 - 6.3e-83 277.4 0.0 8.6e-83 277.0 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_18 PF12847.2 KOO32482.1 - 0.00016 22.1 0.0 0.00032 21.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO32482.1 - 0.00036 20.5 0.1 0.00066 19.7 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_30 PF05430.6 KOO32482.1 - 0.14 11.8 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase Pkinase PF00069.20 KOO32483.1 - 5.6e-10 38.7 0.0 6.5e-10 38.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32483.1 - 9.4e-09 34.7 0.0 1.1e-08 34.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Nuf2 PF03800.9 KOO32484.1 - 3.3e-25 88.7 0.5 1.3e-24 86.8 0.0 2.2 2 0 0 2 2 2 1 Nuf2 family DUF2315 PF10231.4 KOO32484.1 - 0.46 10.3 6.8 0.058 13.2 1.1 2.1 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2315) Reo_sigmaC PF04582.7 KOO32484.1 - 3.9 6.5 6.6 1.5 7.9 1.5 2.2 1 1 2 3 3 3 0 Reovirus sigma C capsid protein Kelch_1 PF01344.20 KOO32485.1 - 0.05 13.1 0.1 0.071 12.6 0.0 1.3 1 0 0 1 1 1 0 Kelch motif EF-hand_5 PF13202.1 KOO32486.1 - 1.4e-06 27.3 0.1 4.7e-06 25.7 0.1 1.8 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO32486.1 - 1.5e-05 25.0 0.0 2.9e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO32486.1 - 2e-05 24.0 0.1 7.3e-05 22.3 0.1 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.27 KOO32486.1 - 5.8e-05 22.0 0.0 0.00016 20.7 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 KOO32486.1 - 0.011 15.2 0.0 0.055 13.0 0.0 2.1 1 1 1 2 2 2 0 EF-hand domain pair EF-hand_10 PF14788.1 KOO32486.1 - 0.055 13.1 0.0 0.17 11.5 0.0 1.9 1 0 0 1 1 1 0 EF hand IQ PF00612.22 KOO32488.1 - 2.7e-06 26.5 16.8 0.00065 19.1 0.9 3.7 3 0 0 3 3 3 3 IQ calmodulin-binding motif PDZ PF00595.19 KOO32488.1 - 0.033 14.3 0.0 0.063 13.4 0.0 1.5 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) cNMP_binding PF00027.24 KOO32489.1 - 2e-67 223.0 0.0 4.9e-19 67.9 0.0 4.5 4 0 0 4 4 4 4 Cyclic nucleotide-binding domain Pkinase PF00069.20 KOO32489.1 - 1.1e-62 211.5 0.0 1.7e-62 210.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32489.1 - 8.8e-35 120.0 0.0 1.6e-34 119.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO32489.1 - 3e-05 23.1 0.0 7.8e-05 21.7 0.0 1.7 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO32489.1 - 0.068 12.8 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 KOO32489.1 - 0.099 11.6 0.0 0.22 10.5 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EF-hand_1 PF00036.27 KOO32490.1 - 5.8e-28 94.0 9.0 3.4e-06 25.9 0.2 5.4 5 0 0 5 5 5 5 EF hand EF-hand_6 PF13405.1 KOO32490.1 - 3e-27 91.9 7.7 5.2e-06 25.8 0.1 5.5 5 0 0 5 5 5 5 EF-hand domain EF-hand_7 PF13499.1 KOO32490.1 - 1.3e-23 82.9 6.2 1.9e-09 37.4 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO32490.1 - 3.1e-18 64.2 16.7 0.00013 21.0 1.0 5.5 5 0 0 5 5 5 5 EF hand EF-hand_8 PF13833.1 KOO32490.1 - 4.8e-18 64.5 15.2 6.2e-06 25.7 0.1 5.2 3 2 2 5 5 5 5 EF-hand domain pair EF-hand_10 PF14788.1 KOO32490.1 - 0.0096 15.5 1.5 6.6 6.4 0.0 3.9 4 1 0 4 4 4 1 EF hand SPARC_Ca_bdg PF10591.4 KOO32490.1 - 0.05 13.6 0.0 7.1 6.6 0.0 2.5 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOO32490.1 - 0.053 13.4 0.0 12 5.8 0.0 3.7 4 0 0 4 4 4 0 EF-hand domain Pkinase PF00069.20 KOO32492.1 - 5.1e-67 225.7 0.0 8.8e-67 224.9 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32492.1 - 1.1e-36 126.3 0.0 1.4e-36 125.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO32492.1 - 4.5e-05 22.5 0.1 9.1e-05 21.5 0.0 1.5 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 KOO32492.1 - 0.00057 19.6 0.1 0.022 14.4 0.0 2.7 1 1 2 3 3 3 1 Phosphotransferase enzyme family Pkinase_C PF00433.19 KOO32492.1 - 0.067 13.7 0.2 0.17 12.4 0.1 1.6 1 0 0 1 1 1 0 Protein kinase C terminal domain ATP_bind_1 PF03029.12 KOO32492.1 - 0.17 11.4 0.1 0.57 9.6 0.0 1.8 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein EF-hand_1 PF00036.27 KOO32493.1 - 6.1e-15 53.3 4.8 4.5e-07 28.7 0.4 3.1 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 KOO32493.1 - 1.6e-11 44.1 2.0 4.2e-11 42.8 1.4 1.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO32493.1 - 2e-11 42.7 3.2 0.00037 20.1 0.0 3.3 2 1 1 3 3 3 2 EF-hand domain EF-hand_5 PF13202.1 KOO32493.1 - 1.4e-10 39.9 6.3 5.2e-05 22.3 0.2 2.7 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO32493.1 - 1.5e-09 37.2 1.8 3.3e-08 33.0 0.4 2.3 1 1 1 2 2 2 2 EF-hand domain pair TPR_10 PF13374.1 KOO32493.1 - 6.4e-05 22.7 0.0 0.0001 22.0 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat EF-hand_9 PF14658.1 KOO32493.1 - 6.5e-05 22.7 0.7 0.00019 21.2 0.0 2.0 3 0 0 3 3 3 1 EF-hand domain EF-hand_4 PF12763.2 KOO32493.1 - 0.0025 17.5 1.4 0.0091 15.7 0.1 1.9 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand TPR_12 PF13424.1 KOO32493.1 - 0.0059 16.5 0.1 0.0094 15.8 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat SPARC_Ca_bdg PF10591.4 KOO32493.1 - 0.11 12.5 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region TPR_12 PF13424.1 KOO32494.1 - 6.6e-25 86.8 24.2 1.1e-08 34.9 0.5 4.9 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.1 KOO32494.1 - 1.2e-14 53.7 42.2 0.00011 22.0 0.3 9.1 8 1 0 8 8 8 6 Tetratricopeptide repeat TPR_11 PF13414.1 KOO32494.1 - 6.4e-09 35.3 11.2 0.0046 16.5 0.1 5.5 4 2 0 4 4 4 3 TPR repeat TPR_1 PF00515.23 KOO32494.1 - 9.5e-07 28.1 6.0 0.69 9.6 0.0 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO32494.1 - 2.2e-05 23.9 22.2 2.7 8.1 0.1 6.9 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.1 KOO32494.1 - 0.007 16.0 21.2 1.7 8.6 0.0 7.0 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO32494.1 - 0.16 12.7 44.0 2.6 8.9 0.5 8.6 8 1 1 9 9 9 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOO32494.1 - 0.4 10.5 7.5 19 5.2 0.0 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_4 PF07721.9 KOO32494.1 - 1.3 9.6 0.1 1.3 9.6 0.0 7.9 8 1 0 8 8 8 0 Tetratricopeptide repeat Pkinase PF00069.20 KOO32496.1 - 1.8e-66 223.9 0.0 2.1e-66 223.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32496.1 - 2.8e-27 95.4 0.0 3.6e-27 95.0 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO32496.1 - 2.1e-06 26.8 0.0 8.3e-06 24.9 0.0 1.8 1 1 1 2 2 2 1 Kinase-like APH PF01636.18 KOO32496.1 - 0.00077 19.2 0.0 0.0013 18.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family IQ PF00612.22 KOO32497.1 - 0.018 14.6 3.3 1.3 8.8 0.6 2.7 2 0 0 2 2 2 0 IQ calmodulin-binding motif UFD1 PF03152.9 KOO32498.1 - 2.7e-09 36.3 0.0 5e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 UBX PF00789.15 KOO32498.1 - 0.0022 18.0 0.0 0.0046 16.9 0.0 1.5 1 0 0 1 1 1 1 UBX domain Prenyltrans PF00432.16 KOO32499.1 - 1.2e-40 136.7 8.1 1.7e-10 40.2 0.2 5.7 5 0 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 KOO32499.1 - 3.5e-20 72.4 0.0 2.7e-12 47.1 0.0 4.1 1 1 2 4 4 4 3 Prenyltransferase-like Prenyltrans_1 PF13243.1 KOO32499.1 - 0.00088 19.2 0.0 0.06 13.3 0.0 3.3 3 1 1 4 4 4 2 Prenyltransferase-like zf-HIT PF04438.11 KOO32500.1 - 1.6e-06 27.6 9.5 2.7e-06 26.9 6.6 1.3 1 0 0 1 1 1 1 HIT zinc finger Neur_chan_memb PF02932.11 KOO32501.1 - 2.9e-05 24.0 0.2 5e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Bac_DNA_binding PF00216.16 KOO32501.1 - 0.022 14.7 0.0 0.062 13.3 0.0 1.7 2 0 0 2 2 2 0 Bacterial DNA-binding protein PARP PF00644.15 KOO32502.1 - 2.9e-06 26.8 0.0 4.7e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DUF484 PF04340.7 KOO32502.1 - 0.00075 19.0 0.8 0.0013 18.2 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF484 DUF3450 PF11932.3 KOO32502.1 - 0.16 11.1 7.3 0.24 10.6 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF3584 PF12128.3 KOO32502.1 - 2.6 5.2 6.1 3.4 4.8 4.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) PulG PF11773.3 KOO32502.1 - 2.6 7.8 4.8 4.7 7.0 3.3 1.3 1 0 0 1 1 1 0 Type II secretory pathway pseudopilin Acyl-CoA_dh_2 PF08028.6 KOO32502.1 - 9.2 6.5 18.4 0.64 10.2 6.3 3.0 4 0 0 4 4 4 0 Acyl-CoA dehydrogenase, C-terminal domain Pkinase PF00069.20 KOO32503.1 - 2.5e-23 82.5 0.0 2.8e-21 75.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32503.1 - 1.2e-05 24.4 0.0 2.3e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO32503.1 - 0.017 14.1 0.0 0.029 13.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 KOO32503.1 - 0.067 12.1 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Zeta_toxin PF06414.7 KOO32504.1 - 5.9e-24 84.2 0.0 8.1e-24 83.8 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.1 KOO32504.1 - 1.9e-09 37.5 0.4 2.9e-09 36.9 0.3 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO32504.1 - 0.00074 20.3 0.0 0.0015 19.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain CPT PF07931.7 KOO32504.1 - 0.00077 19.1 0.1 0.0013 18.4 0.1 1.4 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein Kinesin PF00225.18 KOO32504.1 - 0.039 12.6 0.0 0.094 11.3 0.0 1.5 1 1 1 2 2 2 0 Kinesin motor domain AAA_18 PF13238.1 KOO32504.1 - 0.048 13.9 0.0 0.097 12.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain APS_kinase PF01583.15 KOO32504.1 - 0.048 13.3 0.0 0.081 12.5 0.0 1.5 1 1 0 1 1 1 0 Adenylylsulphate kinase AAA_19 PF13245.1 KOO32504.1 - 0.086 12.6 0.3 4 7.2 0.0 2.5 2 0 0 2 2 2 0 Part of AAA domain MDMPI_N PF11716.3 KOO32505.1 - 0.029 14.7 1.6 0.029 14.7 1.1 3.0 2 1 1 3 3 3 0 Mycothiol maleylpyruvate isomerase N-terminal domain DUF447 PF04289.7 KOO32505.1 - 0.065 12.7 0.7 0.1 12.1 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF447) Atg14 PF10186.4 KOO32505.1 - 0.28 10.0 5.2 0.39 9.6 3.6 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Metal_resist PF13801.1 KOO32505.1 - 5.1 7.1 17.8 2.4 8.1 7.6 3.1 2 1 1 3 3 3 0 Heavy-metal resistance PRP1_N PF06424.7 KOO32507.1 - 4.6e-42 143.5 1.9 1e-41 142.3 1.3 1.7 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.1 KOO32507.1 - 6.5e-28 94.6 41.9 0.013 16.0 0.3 15.1 5 4 10 15 15 15 12 Tetratricopeptide repeat TPR_19 PF14559.1 KOO32507.1 - 1.1e-12 48.1 19.2 0.00077 19.7 0.1 9.1 8 2 1 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO32507.1 - 2.1e-11 44.1 36.9 0.0018 18.8 0.7 8.8 8 2 1 10 10 10 4 Tetratricopeptide repeat TPR_11 PF13414.1 KOO32507.1 - 0.00053 19.5 14.9 1.5 8.4 0.0 7.8 5 4 5 11 11 11 2 TPR repeat TPR_17 PF13431.1 KOO32507.1 - 0.0012 18.8 0.1 20 5.6 0.0 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat Suf PF05843.9 KOO32507.1 - 0.0043 16.8 0.3 1.1 8.9 0.0 4.0 6 0 0 6 6 6 1 Suppressor of forked protein (Suf) TPR_2 PF07719.12 KOO32507.1 - 0.17 11.8 11.3 6 7.0 0.0 7.5 8 0 0 8 8 8 0 Tetratricopeptide repeat SRP54 PF00448.17 KOO32508.1 - 4.7e-54 182.8 0.0 7.8e-54 182.1 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.8 KOO32508.1 - 4.3e-38 131.3 0.0 5.7e-38 130.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal ArgK PF03308.11 KOO32508.1 - 3.2e-06 26.1 0.1 2.2e-05 23.3 0.0 2.2 2 1 0 2 2 2 1 ArgK protein AAA_16 PF13191.1 KOO32508.1 - 6.5e-06 26.2 0.1 0.00036 20.5 0.0 2.8 3 0 0 3 3 3 1 AAA ATPase domain SRP54_N PF02881.14 KOO32508.1 - 1e-05 25.5 0.0 6.9e-05 22.8 0.0 2.3 3 0 0 3 3 3 1 SRP54-type protein, helical bundle domain AAA_22 PF13401.1 KOO32508.1 - 1.8e-05 24.8 0.0 0.00056 20.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.1 KOO32508.1 - 0.00027 20.6 0.0 0.0006 19.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain MobB PF03205.9 KOO32508.1 - 0.00058 19.5 0.0 0.0092 15.6 0.0 2.4 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B CbiA PF01656.18 KOO32508.1 - 0.0016 17.8 0.1 0.0077 15.6 0.1 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain NTPase_1 PF03266.10 KOO32508.1 - 0.049 13.3 0.0 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 NTPase AAA PF00004.24 KOO32508.1 - 0.066 13.4 0.0 0.5 10.5 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Peptidase_M14 PF00246.19 KOO32509.1 - 2.6e-32 112.5 0.0 3.6e-32 112.0 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase PknH_C PF14032.1 KOO32510.1 - 0.039 13.5 1.0 0.044 13.3 0.7 1.1 1 0 0 1 1 1 0 PknH-like extracellular domain BRE1 PF08647.6 KOO32511.1 - 0.0051 16.7 4.3 0.0051 16.7 3.0 5.7 4 2 3 7 7 7 1 BRE1 E3 ubiquitin ligase GPW_gp25 PF04965.9 KOO32511.1 - 1.4 8.4 8.0 0.24 10.9 0.9 2.9 3 0 0 3 3 3 0 Gene 25-like lysozyme Reo_sigmaC PF04582.7 KOO32511.1 - 2.2 7.3 9.0 0.62 9.1 0.4 2.4 2 1 0 2 2 2 0 Reovirus sigma C capsid protein DUF4613 PF15390.1 KOO32511.1 - 6.3 4.8 25.8 0.0075 14.5 6.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4613) FAD_binding_4 PF01565.18 KOO32512.1 - 5.6e-14 51.7 0.5 1.1e-13 50.8 0.4 1.6 1 1 0 1 1 1 1 FAD binding domain Spc7 PF08317.6 KOO32513.1 - 0.0044 15.7 1.8 0.0044 15.7 1.3 5.3 1 1 5 6 6 6 2 Spc7 kinetochore protein eIF-3_zeta PF05091.7 KOO32515.1 - 3.7e-161 537.2 0.0 5.1e-161 536.8 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DEAD PF00270.24 KOO32517.1 - 3.3e-09 36.4 0.1 5.2e-09 35.8 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase PV-1 PF06637.6 KOO32517.1 - 0.15 10.5 1.3 0.29 9.6 0.7 1.5 2 0 0 2 2 2 0 PV-1 protein (PLVAP) YSIRK_signal PF04650.12 KOO32517.1 - 1.6 8.3 3.7 2.8 7.5 2.6 1.4 1 0 0 1 1 1 0 YSIRK type signal peptide Dus PF01207.12 KOO32518.1 - 1.7e-61 207.7 0.0 3.6e-61 206.6 0.0 1.5 1 1 1 2 2 2 1 Dihydrouridine synthase (Dus) ThiG PF05690.9 KOO32518.1 - 1.8e-05 23.9 0.3 3.3e-05 23.0 0.2 1.3 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG His_biosynth PF00977.16 KOO32518.1 - 3.2e-05 23.3 0.1 6.8e-05 22.2 0.0 1.5 2 0 0 2 2 2 1 Histidine biosynthesis protein NMO PF03060.10 KOO32518.1 - 0.00012 21.3 1.0 0.00021 20.5 0.7 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase DHO_dh PF01180.16 KOO32518.1 - 0.004 16.1 0.5 0.014 14.3 0.3 1.9 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase TMP-TENI PF02581.12 KOO32518.1 - 0.0077 15.3 0.3 0.012 14.7 0.2 1.3 1 0 0 1 1 1 1 Thiamine monophosphate synthase/TENI IMPDH PF00478.20 KOO32518.1 - 0.017 14.0 2.5 0.026 13.3 1.8 1.2 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain SOR_SNZ PF01680.12 KOO32518.1 - 0.089 12.3 0.0 0.42 10.1 0.0 1.9 2 0 0 2 2 2 0 SOR/SNZ family RE_Alw26IDE PF09665.5 KOO32519.1 - 0.27 9.9 6.5 0.34 9.5 4.5 1.1 1 0 0 1 1 1 0 Type II restriction endonuclease (RE_Alw26IDE) Pkinase PF00069.20 KOO32520.1 - 1.1e-55 188.6 0.0 1.4e-55 188.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32520.1 - 7.3e-24 84.2 0.0 1e-23 83.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DSPc PF00782.15 KOO32520.1 - 1.4e-17 63.5 0.0 3.1e-17 62.4 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Kinase-like PF14531.1 KOO32520.1 - 6.3e-05 22.0 0.0 0.00011 21.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO32520.1 - 0.0083 15.8 0.0 0.018 14.7 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 KOO32520.1 - 0.021 14.3 0.1 0.11 12.0 0.0 1.8 1 1 0 2 2 2 0 Choline/ethanolamine kinase Kdo PF06293.9 KOO32520.1 - 0.15 11.0 0.0 0.25 10.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Y_phosphatase PF00102.22 KOO32520.1 - 0.22 10.8 1.9 0.39 10.0 0.0 2.3 3 0 0 3 3 3 0 Protein-tyrosine phosphatase UDPG_MGDP_dh_N PF03721.9 KOO32521.1 - 2.3e-55 186.8 0.0 3.4e-55 186.2 0.0 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.10 KOO32521.1 - 6.3e-35 119.5 0.1 5.7e-34 116.4 0.0 2.2 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.14 KOO32521.1 - 1.1e-32 112.0 0.0 2.6e-32 110.8 0.0 1.7 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain PTS-HPr PF00381.14 KOO32521.1 - 0.12 12.2 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 PTS HPr component phosphorylation site TPR_11 PF13414.1 KOO32523.1 - 1.2e-45 152.9 30.4 3.7e-16 58.5 3.5 5.7 3 2 2 5 5 5 5 TPR repeat TPR_1 PF00515.23 KOO32523.1 - 5.7e-39 130.1 31.3 3.9e-07 29.4 0.4 8.5 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_2 PF07719.12 KOO32523.1 - 3.7e-27 92.0 39.2 0.00017 21.2 0.1 9.1 9 0 0 9 9 8 7 Tetratricopeptide repeat TPR_12 PF13424.1 KOO32523.1 - 3.6e-15 55.6 32.6 1.8e-07 31.0 1.3 5.4 2 2 3 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.1 KOO32523.1 - 1.6e-13 49.3 9.0 0.069 12.9 0.0 6.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.1 KOO32523.1 - 4.3e-13 49.5 42.2 0.0014 19.2 2.3 7.0 5 1 2 7 7 6 5 Tetratricopeptide repeat TPR_17 PF13431.1 KOO32523.1 - 3.5e-10 39.2 16.7 0.02 15.0 0.5 7.0 7 0 0 7 7 6 3 Tetratricopeptide repeat RPAP3_C PF13877.1 KOO32523.1 - 3.7e-08 33.2 0.0 1e-07 31.8 0.0 1.7 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 TPR_19 PF14559.1 KOO32523.1 - 4.5e-08 33.3 21.0 0.087 13.1 0.7 5.9 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO32523.1 - 7.7e-08 31.5 20.8 0.031 14.0 0.0 7.2 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_9 PF13371.1 KOO32523.1 - 7.1e-07 28.9 24.9 1.1 9.2 1.4 7.0 3 2 3 6 6 6 5 Tetratricopeptide repeat TPR_14 PF13428.1 KOO32523.1 - 3.7e-05 23.9 36.2 0.031 14.9 0.2 8.0 5 2 3 8 8 6 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOO32523.1 - 0.00024 21.3 28.6 1.9 9.1 0.1 8.3 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_3 PF07720.7 KOO32523.1 - 0.031 14.0 0.5 0.11 12.3 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.1 KOO32523.1 - 0.06 13.2 0.1 0.06 13.2 0.1 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat SPO22 PF08631.5 KOO32523.1 - 0.21 10.6 5.3 5.6 5.9 0.2 3.1 3 1 1 4 4 4 0 Meiosis protein SPO22/ZIP4 like Fis1_TPR_C PF14853.1 KOO32523.1 - 0.92 9.4 14.3 0.97 9.3 0.0 4.9 5 1 1 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat RNase_T PF00929.19 KOO32524.1 - 0.0013 19.0 0.0 0.012 15.9 0.0 2.1 1 1 0 1 1 1 1 Exonuclease SPX PF03105.14 KOO32525.1 - 4.6e-10 39.7 0.2 0.00042 20.2 0.1 2.1 2 0 0 2 2 2 2 SPX domain AAA PF00004.24 KOO32526.1 - 1.1e-34 119.5 0.0 1.8e-34 118.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO32526.1 - 5.4e-07 29.7 3.5 0.00038 20.4 0.0 3.2 2 1 1 3 3 3 2 AAA ATPase domain RuvB_N PF05496.7 KOO32526.1 - 1.4e-05 24.2 0.0 3.9e-05 22.8 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus TIP49 PF06068.8 KOO32526.1 - 8.9e-05 21.3 0.0 0.00036 19.3 0.0 1.7 1 1 1 2 2 2 1 TIP49 C-terminus IstB_IS21 PF01695.12 KOO32526.1 - 9e-05 21.9 0.0 0.00015 21.2 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.1 KOO32526.1 - 0.0001 22.4 0.0 0.00083 19.5 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO32526.1 - 0.00012 22.8 0.0 0.00032 21.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.9 KOO32526.1 - 0.00026 20.7 0.0 0.0017 18.1 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 KOO32526.1 - 0.00029 20.0 0.1 0.002 17.2 0.0 2.0 2 0 0 2 2 2 1 Zeta toxin AAA_19 PF13245.1 KOO32526.1 - 0.00031 20.4 0.1 0.00031 20.4 0.0 2.3 3 0 0 3 3 1 1 Part of AAA domain AAA_33 PF13671.1 KOO32526.1 - 0.00033 20.5 0.2 0.00072 19.4 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_14 PF13173.1 KOO32526.1 - 0.00072 19.4 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 KOO32526.1 - 0.0014 18.1 0.0 0.0026 17.2 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.1 KOO32526.1 - 0.0017 18.6 0.0 0.0033 17.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.21 KOO32526.1 - 0.0026 17.2 0.0 0.012 15.1 0.0 2.2 1 1 0 1 1 1 1 Sigma-54 interaction domain NACHT PF05729.7 KOO32526.1 - 0.0031 17.1 0.1 0.077 12.6 0.0 2.5 1 1 1 2 2 2 1 NACHT domain AFG1_ATPase PF03969.11 KOO32526.1 - 0.0078 15.0 0.6 0.057 12.2 0.4 2.0 1 1 0 1 1 1 1 AFG1-like ATPase Mg_chelatase PF01078.16 KOO32526.1 - 0.017 14.3 0.1 0.034 13.2 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ResIII PF04851.10 KOO32526.1 - 0.021 14.6 0.0 0.029 14.2 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_11 PF13086.1 KOO32526.1 - 0.021 14.4 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 KOO32526.1 - 0.025 14.5 0.7 0.056 13.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.1 KOO32526.1 - 0.029 14.4 0.0 0.062 13.3 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_25 PF13481.1 KOO32526.1 - 0.029 13.7 0.3 0.19 11.1 0.1 2.3 1 1 1 2 2 2 0 AAA domain AAA_2 PF07724.9 KOO32526.1 - 0.033 14.1 0.0 0.085 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.17 KOO32526.1 - 0.042 14.0 0.0 0.083 13.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase UPF0079 PF02367.12 KOO32526.1 - 0.046 13.3 0.0 0.086 12.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Parvo_NS1 PF01057.12 KOO32526.1 - 0.062 12.1 0.0 0.096 11.5 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 PhoH PF02562.11 KOO32526.1 - 0.063 12.4 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein NB-ARC PF00931.17 KOO32526.1 - 0.068 12.0 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_3 PF07726.6 KOO32526.1 - 0.11 12.1 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.4 KOO32526.1 - 0.11 11.4 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ISN1 PF06437.6 KOO32527.1 - 1e-91 307.6 0.0 1.2e-91 307.5 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase Hydrolase_3 PF08282.7 KOO32527.1 - 0.1 12.1 0.0 9.2 5.7 0.0 2.4 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase DHC_N1 PF08385.7 KOO32528.1 - 6.5e-128 427.6 18.1 1.4e-127 426.5 12.5 1.6 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 Na_sulph_symp PF00939.14 KOO32529.1 - 5.7e-10 38.6 7.9 6.9e-10 38.3 5.5 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.11 KOO32529.1 - 2.6e-06 26.2 9.3 2.7e-06 26.1 6.5 1.0 1 0 0 1 1 1 1 Citrate transporter ArsB PF02040.10 KOO32529.1 - 0.00056 18.9 3.8 0.00062 18.8 2.6 1.0 1 0 0 1 1 1 1 Arsenical pump membrane protein CitMHS PF03600.11 KOO32530.1 - 2.7e-08 32.7 9.5 7.2e-08 31.3 5.5 1.9 1 1 1 2 2 2 2 Citrate transporter Methyltransf_10 PF05971.7 KOO32531.1 - 7.6e-78 261.6 0.0 1e-77 261.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF890) MTS PF05175.9 KOO32531.1 - 0.092 12.1 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Ank_2 PF12796.2 KOO32532.1 - 7.6e-22 77.4 1.4 1.2e-09 38.4 0.2 4.0 4 0 0 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO32532.1 - 4.5e-17 60.9 7.1 3.5e-05 23.3 0.0 5.4 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.1 KOO32532.1 - 2.5e-14 52.9 7.5 7.3e-06 26.0 0.1 4.9 5 0 0 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO32532.1 - 1.7e-11 43.1 8.3 0.00017 21.5 0.1 5.1 5 0 0 5 5 4 3 Ankyrin repeat EF-hand_7 PF13499.1 KOO32532.1 - 1.6e-09 37.7 0.1 7.6e-09 35.5 0.1 2.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO32532.1 - 5.2e-09 35.2 0.3 0.00012 21.6 0.0 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO32532.1 - 1.6e-08 33.2 0.0 2.7e-05 23.1 0.0 2.9 2 0 0 2 2 2 2 EF hand Ank_4 PF13637.1 KOO32532.1 - 1.8e-07 31.4 1.4 0.36 11.4 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeats (many copies) ART PF01129.13 KOO32532.1 - 3.2e-07 29.6 0.0 3.2e-07 29.6 0.0 2.3 2 0 0 2 2 1 1 NAD:arginine ADP-ribosyltransferase EF-hand_5 PF13202.1 KOO32532.1 - 1.2e-05 24.4 0.1 0.0027 16.9 0.0 3.0 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.1 KOO32532.1 - 0.0028 17.2 0.1 0.031 13.8 0.0 2.7 1 1 1 2 2 2 1 EF-hand domain pair GrpE PF01025.14 KOO32532.1 - 0.0048 16.4 7.7 0.0048 16.4 5.3 3.0 2 0 0 2 2 2 1 GrpE Arm PF00514.18 KOO32534.1 - 2.9e-06 26.8 11.3 0.14 12.0 0.0 6.2 7 0 0 7 7 7 2 Armadillo/beta-catenin-like repeat HEAT PF02985.17 KOO32534.1 - 0.00034 20.4 17.4 0.37 11.0 0.0 6.5 7 1 1 8 8 8 3 HEAT repeat HEAT_2 PF13646.1 KOO32534.1 - 0.002 18.3 14.4 0.012 15.9 0.4 4.1 2 1 2 4 4 4 1 HEAT repeats Cohesin_HEAT PF12765.2 KOO32534.1 - 0.027 14.4 0.2 0.076 12.9 0.2 1.8 1 0 0 1 1 1 0 HEAT repeat associated with sister chromatid cohesion Cnd1 PF12717.2 KOO32534.1 - 0.037 13.8 0.0 29 4.4 0.0 3.1 1 1 2 3 3 3 0 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.1 KOO32534.1 - 0.086 13.3 17.0 0.69 10.4 0.3 5.7 6 1 1 7 7 7 0 HEAT-like repeat EF-hand_1 PF00036.27 KOO32535.1 - 1.4e-11 42.8 3.7 2.9e-05 23.0 0.2 2.8 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 KOO32535.1 - 1.7e-10 40.8 0.4 7.6e-05 22.7 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO32535.1 - 7.7e-10 37.6 3.0 9.9e-06 24.6 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO32535.1 - 2.6e-09 36.1 3.6 0.0017 18.0 0.5 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO32535.1 - 0.00023 20.7 0.5 0.11 12.1 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair RRM_6 PF14259.1 KOO32536.1 - 8.2e-25 86.5 0.0 6.4e-08 32.4 0.0 3.8 3 1 1 4 4 4 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOO32536.1 - 3e-22 78.0 0.0 2.4e-09 36.6 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO32536.1 - 6.9e-09 35.4 0.0 0.0004 20.1 0.0 3.4 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 KOO32536.1 - 0.003 17.3 0.0 0.02 14.7 0.0 2.0 2 0 0 2 2 2 1 RNA binding motif ARGLU PF15346.1 KOO32537.1 - 0.0054 16.5 10.9 0.0054 16.5 7.6 3.7 4 0 0 4 4 4 1 Arginine and glutamate-rich 1 V_ATPase_I PF01496.14 KOO32537.1 - 1.6 6.5 4.1 6.2 4.5 0.0 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Uteroglobin PF01099.12 KOO32537.1 - 1.8 8.4 5.5 9.7 6.0 0.3 2.6 2 0 0 2 2 2 0 Uteroglobin family rve PF00665.21 KOO32538.1 - 4.1e-15 55.9 0.0 7.7e-15 55.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Nuc_rec_co-act PF08815.5 KOO32538.1 - 0.088 12.3 0.0 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 Nuclear receptor coactivator PABP PF00658.13 KOO32538.1 - 0.17 11.5 0.0 0.35 10.5 0.0 1.5 1 0 0 1 1 1 0 Poly-adenylate binding protein, unique domain RVT_2 PF07727.9 KOO32540.1 - 2.9e-36 124.6 0.0 4.4e-36 124.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KOO32540.1 - 5.2e-15 55.6 0.0 9.1e-15 54.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain LRR_4 PF12799.2 KOO32541.1 - 1.9e-25 88.0 27.5 0.00011 21.6 0.8 7.8 3 2 6 9 9 9 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO32541.1 - 2e-24 85.0 26.2 1.8e-06 27.5 1.3 6.3 1 1 6 7 7 7 7 Leucine rich repeat LRR_1 PF00560.28 KOO32541.1 - 8.8e-18 61.6 28.7 0.47 10.6 0.0 12.0 12 0 0 12 12 12 8 Leucine Rich Repeat LRR_7 PF13504.1 KOO32541.1 - 1.3e-10 39.6 40.4 1.2 9.6 0.0 11.9 12 0 0 12 12 12 5 Leucine rich repeat ADPrib_exo_Tox PF03496.9 KOO32541.1 - 0.004 16.4 0.0 0.0081 15.3 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme ART PF01129.13 KOO32541.1 - 0.083 11.9 0.0 0.2 10.7 0.0 1.6 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase U-box PF04564.10 KOO32544.1 - 1.3e-13 50.7 0.0 2.2e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 U-box domain Sel1 PF08238.7 KOO32544.1 - 3e-06 27.6 0.6 7e-06 26.5 0.4 1.7 1 0 0 1 1 1 1 Sel1 repeat zf-Nse PF11789.3 KOO32544.1 - 0.0011 18.4 0.0 0.0031 17.0 0.0 1.8 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit Myco_19_kDa PF05481.7 KOO32545.1 - 0.064 13.0 3.4 0.048 13.4 0.8 1.9 2 0 0 2 2 2 0 Mycobacterium 19 kDa lipoprotein antigen GCHY-1 PF02649.9 KOO32545.1 - 0.11 11.7 0.0 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 Type I GTP cyclohydrolase folE2 DUF1771 PF08590.5 KOO32545.1 - 0.64 10.0 2.7 8 6.5 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1771) Glyco_transf_90 PF05686.7 KOO32546.1 - 1.8e-25 89.4 0.0 3.6e-25 88.5 0.0 1.3 1 1 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.1 KOO32546.1 - 0.0027 17.9 0.0 0.0058 16.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 GRAM PF02893.15 KOO32546.1 - 0.11 12.0 0.0 0.26 10.8 0.0 1.5 1 0 0 1 1 1 0 GRAM domain Ank_2 PF12796.2 KOO32547.1 - 4.5e-70 232.0 23.0 1.2e-16 60.7 0.6 7.8 2 1 5 8 8 8 7 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO32547.1 - 3.2e-52 174.0 3.6 2e-09 37.7 0.1 10.4 5 2 4 10 10 10 9 Ankyrin repeats (many copies) Ank PF00023.25 KOO32547.1 - 1.3e-46 154.1 21.1 5.8e-05 22.6 0.1 14.3 13 1 1 14 14 14 10 Ankyrin repeat Ank_5 PF13857.1 KOO32547.1 - 1.2e-30 104.8 21.2 1.6e-05 25.0 0.1 10.9 5 3 7 12 12 11 8 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO32547.1 - 1.6e-27 92.8 10.5 0.029 14.6 0.0 14.0 14 0 0 14 14 13 5 Ankyrin repeat PUB PF09409.5 KOO32547.1 - 4.3e-15 55.2 0.0 1e-14 54.0 0.0 1.6 1 0 0 1 1 1 1 PUB domain SAM_1 PF00536.25 KOO32547.1 - 7.3e-07 29.2 0.4 0.011 15.8 0.0 2.8 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) ResIII PF04851.10 KOO32547.1 - 8e-07 29.0 0.1 0.00032 20.5 0.0 2.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ADPrib_exo_Tox PF03496.9 KOO32547.1 - 2.8e-05 23.4 0.0 0.0048 16.1 0.0 2.2 2 0 0 2 2 2 1 ADP-ribosyltransferase exoenzyme SAM_2 PF07647.12 KOO32547.1 - 5.3e-05 22.9 0.1 0.015 15.1 0.0 3.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) DEAD PF00270.24 KOO32547.1 - 0.0065 15.9 0.0 0.044 13.2 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_12 PF13087.1 KOO32547.1 - 0.073 12.4 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 KOO32547.1 - 0.11 11.8 0.1 0.51 9.7 0.0 2.2 2 0 0 2 2 2 0 AAA-like domain IQ PF00612.22 KOO32547.1 - 0.15 11.7 3.3 0.47 10.2 2.3 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif PhoH PF02562.11 KOO32547.1 - 0.24 10.6 0.0 0.5 9.5 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein RSN1_TM PF13967.1 KOO32547.1 - 0.86 9.1 1.1 11 5.5 0.0 2.7 3 0 0 3 3 3 0 Late exocytosis, associated with Golgi transport Filamin PF00630.14 KOO32548.1 - 1.1e-16 61.1 0.0 0.0001 22.8 0.0 4.3 2 1 1 3 3 3 3 Filamin/ABP280 repeat Big_3_4 PF13754.1 KOO32548.1 - 0.024 14.9 0.5 31 5.0 0.0 4.6 5 0 0 5 5 5 0 Bacterial Ig-like domain (group 3) Herpes_BLLF1 PF05109.8 KOO32548.1 - 6.4 4.5 23.1 9.5 4.0 16.0 1.2 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) Ank_2 PF12796.2 KOO32549.1 - 4.9e-06 26.7 0.0 1.7e-05 25.0 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) CHAT PF12770.2 KOO32549.1 - 0.00021 20.5 0.1 0.00037 19.7 0.1 1.4 1 0 0 1 1 1 1 CHAT domain Ank_3 PF13606.1 KOO32549.1 - 0.0046 17.0 0.0 0.84 10.0 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.1 KOO32549.1 - 0.0055 16.9 0.1 3.7 7.9 0.0 3.5 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.25 KOO32549.1 - 0.0072 16.0 0.0 3.6 7.5 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.1 KOO32549.1 - 0.11 13.0 0.0 2.5 8.7 0.0 2.9 1 1 1 2 2 2 0 Ankyrin repeats (many copies) UIM PF02809.15 KOO32549.1 - 0.27 10.8 4.1 0.91 9.2 2.8 1.9 1 0 0 1 1 1 0 Ubiquitin interaction motif Metallophos PF00149.23 KOO32550.1 - 0.0037 16.6 0.0 0.0046 16.3 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Alpha_kinase PF02816.13 KOO32551.1 - 1.9e-25 89.6 0.0 3.5e-25 88.7 0.0 1.3 1 0 0 1 1 1 1 Alpha-kinase family VWA PF00092.23 KOO32551.1 - 0.00044 20.0 0.0 0.001 18.8 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain Shugoshin_N PF07558.6 KOO32551.1 - 0.073 12.7 5.1 19 5.0 0.0 4.1 5 0 0 5 5 5 0 Shugoshin N-terminal coiled-coil region Ribosomal_L13e PF01294.13 KOO32552.1 - 5.3e-06 26.0 3.0 0.078 12.4 0.1 3.3 1 1 2 3 3 3 3 Ribosomal protein L13e RPAP1_C PF08620.5 KOO32552.1 - 0.00033 20.4 5.5 7.6 6.4 0.0 5.1 1 1 5 6 6 6 3 RPAP1-like, C-terminal SinI PF08671.5 KOO32552.1 - 0.022 14.1 0.8 9.5 5.7 0.0 3.3 4 0 0 4 4 4 0 Anti-repressor SinI Pyr_redox_dim PF02852.17 KOO32552.1 - 0.18 11.8 6.2 10 6.2 0.2 3.1 1 1 2 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain DUF4473 PF14747.1 KOO32553.1 - 0.063 13.5 42.3 1.2 9.3 1.6 7.2 2 1 4 6 6 6 0 Domain of unknown function (DUF4473) Pkinase PF00069.20 KOO32554.1 - 4.9e-47 160.2 0.0 7.4e-47 159.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32554.1 - 8.1e-29 100.4 0.0 1.8e-25 89.5 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 KOO32554.1 - 1.7e-10 40.3 0.0 1.3e-05 24.3 0.0 2.7 3 0 0 3 3 3 2 Kinase-like ABC1 PF03109.11 KOO32554.1 - 0.073 13.0 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 ABC1 family APH PF01636.18 KOO32554.1 - 1.1 8.9 7.1 8.2 6.0 4.6 2.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.20 KOO32555.1 - 1.1e-25 90.2 0.0 1.4e-25 89.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32555.1 - 2.7e-22 79.0 0.0 3.5e-22 78.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO32555.1 - 0.0013 18.5 3.8 0.0056 16.4 0.2 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family TAP42 PF04177.7 KOO32557.1 - 0.0015 17.5 8.9 0.002 17.1 6.1 1.0 1 0 0 1 1 1 1 TAP42-like family SPX PF03105.14 KOO32557.1 - 0.0036 17.1 0.9 0.0036 17.1 0.6 1.2 1 0 0 1 1 1 1 SPX domain Syntaxin PF00804.20 KOO32557.1 - 0.1 12.7 3.4 0.17 12.0 2.4 1.3 1 0 0 1 1 1 0 Syntaxin DUF2854 PF11016.3 KOO32557.1 - 0.18 11.3 1.5 0.3 10.6 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2854) Dor1 PF04124.7 KOO32557.1 - 0.18 10.2 2.8 0.22 9.9 2.0 1.1 1 0 0 1 1 1 0 Dor1-like family APG6 PF04111.7 KOO32557.1 - 1.9 7.4 7.9 2.3 7.2 5.4 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 zf-trcl PF13451.1 KOO32558.1 - 4.2e-14 51.9 1.4 4.2e-14 51.9 1.0 2.5 2 1 0 2 2 2 1 Probable zinc-binding domain SART-1 PF03343.8 KOO32560.1 - 0.14 10.5 1.5 0.17 10.2 1.1 1.0 1 0 0 1 1 1 0 SART-1 family Nop14 PF04147.7 KOO32560.1 - 7.7 4.3 6.3 9.2 4.0 4.3 1.0 1 0 0 1 1 1 0 Nop14-like family adh_short PF00106.20 KOO32561.1 - 1.3e-05 25.1 0.0 2.9e-05 24.0 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase DEAD PF00270.24 KOO32562.1 - 3.2e-48 163.4 0.0 2.5e-47 160.5 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO32562.1 - 2.1e-27 94.8 0.0 1.8e-26 91.7 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO32562.1 - 0.00011 22.0 0.0 0.0016 18.2 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 KOO32562.1 - 0.1 12.7 0.3 0.89 9.7 0.2 2.3 1 1 0 1 1 1 0 AAA domain SMC_hinge PF06470.8 KOO32563.1 - 3.7e-26 91.4 0.0 1.6e-25 89.4 0.0 2.1 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain SMC_N PF02463.14 KOO32563.1 - 2.9e-21 75.7 22.6 3.9e-21 75.3 15.6 1.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 KOO32563.1 - 2e-06 27.2 0.0 4.2e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.1 KOO32563.1 - 4.8e-06 26.7 0.0 1.1e-05 25.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.1 KOO32563.1 - 0.0016 18.7 44.1 0.0016 18.7 30.6 5.1 2 2 0 3 3 3 1 AAA domain ABC_tran PF00005.22 KOO32563.1 - 0.69 10.2 0.0 0.69 10.2 0.0 5.5 3 2 0 3 3 3 0 ABC transporter Epimerase PF01370.16 KOO32564.1 - 3.2e-40 138.0 0.0 5.2e-40 137.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 KOO32564.1 - 6.6e-11 41.6 0.0 1e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_8 PF13450.1 KOO32564.1 - 1.3e-10 41.1 1.0 2.3e-07 30.7 0.0 3.5 3 0 0 3 3 3 2 NAD(P)-binding Rossmann-like domain 3Beta_HSD PF01073.14 KOO32564.1 - 1.9e-10 39.9 0.0 1.7e-09 36.8 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 KOO32564.1 - 1.1e-09 37.6 0.0 6e-09 35.2 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.20 KOO32564.1 - 5.1e-08 33.0 0.1 1e-07 32.0 0.1 1.5 1 0 0 1 1 1 1 short chain dehydrogenase Amino_oxidase PF01593.19 KOO32564.1 - 4.4e-07 29.3 0.0 0.0017 17.4 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.1 KOO32564.1 - 2.1e-06 27.9 0.1 0.00061 19.9 0.0 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_10 PF13460.1 KOO32564.1 - 1.2e-05 25.4 0.5 2.7e-05 24.2 0.0 1.9 2 0 0 2 2 1 1 NADH(P)-binding DAO PF01266.19 KOO32564.1 - 3.2e-05 23.0 0.1 0.015 14.1 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase KR PF08659.5 KOO32564.1 - 7.9e-05 22.3 0.1 0.00015 21.4 0.1 1.4 1 0 0 1 1 1 1 KR domain Saccharop_dh PF03435.13 KOO32564.1 - 0.0012 17.9 0.3 0.0026 16.8 0.1 1.6 2 0 0 2 2 2 1 Saccharopine dehydrogenase NmrA PF05368.8 KOO32564.1 - 0.0025 17.0 0.1 0.0045 16.2 0.1 1.4 1 0 0 1 1 1 1 NmrA-like family Pyr_redox PF00070.22 KOO32564.1 - 0.0028 18.0 0.9 1.6 9.2 0.0 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 KOO32564.1 - 0.011 15.6 0.1 1.4 8.7 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Epimerase_Csub PF13950.1 KOO32564.1 - 0.019 14.9 0.1 0.047 13.6 0.0 1.6 1 0 0 1 1 1 0 UDP-glucose 4-epimerase C-term subunit NAD_binding_9 PF13454.1 KOO32564.1 - 0.025 14.3 0.2 2.5 7.8 0.0 3.3 3 0 0 3 3 3 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.19 KOO32564.1 - 0.033 13.0 0.0 0.073 11.9 0.0 1.5 1 0 0 1 1 1 0 FAD binding domain FAD_binding_3 PF01494.14 KOO32564.1 - 0.15 11.0 0.3 0.49 9.3 0.0 1.8 2 0 0 2 2 2 0 FAD binding domain Shikimate_DH PF01488.15 KOO32564.1 - 0.25 11.4 0.0 2 8.5 0.0 2.3 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.9 KOO32564.1 - 0.25 9.7 0.0 0.42 9.0 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein UBA_4 PF14555.1 KOO32565.1 - 6.5e-10 38.3 0.0 1.5e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain WD40 PF00400.27 KOO32566.1 - 1.3e-28 97.7 13.1 1.7e-06 27.7 0.1 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat SPRY PF00622.23 KOO32566.1 - 0.03 14.4 0.0 0.066 13.2 0.0 1.5 1 0 0 1 1 1 0 SPRY domain PQQ_3 PF13570.1 KOO32566.1 - 1.6 9.1 9.0 27 5.2 0.0 4.4 3 1 1 4 4 4 0 PQQ-like domain Aldose_epim PF01263.15 KOO32567.1 - 1e-28 100.3 0.0 2.2e-28 99.2 0.0 1.5 1 1 0 1 1 1 1 Aldose 1-epimerase DUF1470 PF07336.6 KOO32568.1 - 4.5e-05 23.7 1.6 0.073 13.3 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF1470) Arm PF00514.18 KOO32569.1 - 7.2e-128 412.6 100.2 5.2e-07 29.2 0.1 34.2 35 0 0 35 35 35 27 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO32569.1 - 1.6e-23 82.8 104.9 1.6e-06 28.2 3.1 15.4 4 4 13 18 18 18 10 HEAT repeats V-ATPase_H_N PF03224.9 KOO32569.1 - 5.6e-11 42.1 4.3 0.012 14.7 0.8 7.0 3 2 0 3 3 3 2 V-ATPase subunit H Arm_2 PF04826.8 KOO32569.1 - 9e-10 38.0 2.4 1.4 8.0 0.0 9.3 7 2 3 11 11 11 2 Armadillo-like Atx10homo_assoc PF09759.4 KOO32569.1 - 6.2e-09 35.5 3.3 2.6 7.8 0.0 8.6 6 3 5 11 11 11 2 Spinocerebellar ataxia type 10 protein domain Adaptin_N PF01602.15 KOO32569.1 - 1.8e-05 23.2 9.5 3.9 5.6 0.7 7.4 4 2 4 9 9 9 2 Adaptin N terminal region Cnd1 PF12717.2 KOO32569.1 - 5e-05 23.2 0.2 3.7 7.3 0.0 5.2 6 0 0 6 6 6 1 non-SMC mitotic condensation complex subunit 1 RICTOR_N PF14664.1 KOO32569.1 - 6.1e-05 21.7 2.4 0.45 9.0 0.0 6.4 5 2 2 7 7 7 1 Rapamycin-insensitive companion of mTOR, N-term HEAT_EZ PF13513.1 KOO32569.1 - 0.00099 19.5 2.2 0.00099 19.5 1.6 16.8 14 6 9 23 23 22 4 HEAT-like repeat RYDR_ITPR PF01365.16 KOO32569.1 - 0.0022 17.2 0.1 0.31 10.2 0.1 3.3 3 0 0 3 3 3 1 RIH domain V-ATPase_H_C PF11698.3 KOO32569.1 - 0.0053 16.6 0.1 10 6.0 0.0 4.7 5 0 0 5 5 5 1 V-ATPase subunit H Peptidase_C26 PF07722.8 KOO32569.1 - 0.023 14.1 0.2 3.2 7.1 0.0 3.5 3 0 0 3 3 3 0 Peptidase C26 DUF913 PF06025.7 KOO32569.1 - 0.045 12.4 0.1 35 2.9 0.0 4.6 4 0 0 4 4 4 0 Domain of Unknown Function (DUF913) HEAT PF02985.17 KOO32569.1 - 0.051 13.6 42.0 6.4 7.1 0.1 13.7 13 0 0 13 13 13 0 HEAT repeat WD40 PF00400.27 KOO32570.1 - 2.5e-06 27.1 5.3 0.013 15.4 0.0 4.5 6 0 0 6 6 6 2 WD domain, G-beta repeat EF-hand_7 PF13499.1 KOO32572.1 - 0.011 15.8 0.0 0.022 14.8 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.1 KOO32572.1 - 0.011 15.5 0.1 0.026 14.3 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain DUF2681 PF10883.3 KOO32572.1 - 0.021 15.0 0.2 0.058 13.6 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) EF-hand_1 PF00036.27 KOO32572.1 - 0.06 12.6 0.3 0.13 11.6 0.2 1.6 1 0 0 1 1 1 0 EF hand PDZ_2 PF13180.1 KOO32573.1 - 5.1e-08 32.7 0.1 0.0019 18.0 0.0 2.5 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.19 KOO32573.1 - 5.4e-08 32.8 0.0 0.00026 21.0 0.0 2.6 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) DUF2457 PF10446.4 KOO32573.1 - 0.18 10.4 7.3 0.27 9.9 5.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) BPL_LplA_LipB PF03099.14 KOO32574.1 - 5e-15 55.6 0.1 6.7e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family EF-hand_1 PF00036.27 KOO32575.1 - 8.3e-05 21.6 0.2 0.00018 20.5 0.1 1.6 1 0 0 1 1 1 1 EF hand LRR_8 PF13855.1 KOO32575.1 - 0.00084 19.0 4.5 0.004 16.8 2.8 2.4 2 0 0 2 2 2 1 Leucine rich repeat EF-hand_8 PF13833.1 KOO32575.1 - 0.0018 17.8 0.4 0.0056 16.2 0.2 1.8 1 0 0 1 1 1 1 EF-hand domain pair LRR_4 PF12799.2 KOO32575.1 - 0.0026 17.3 5.8 0.097 12.3 0.3 2.9 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) EF-hand_5 PF13202.1 KOO32575.1 - 0.0061 15.8 0.3 0.014 14.7 0.2 1.6 1 0 0 1 1 1 1 EF hand LRR_1 PF00560.28 KOO32575.1 - 0.0069 16.2 4.1 15 6.0 0.0 4.7 4 0 0 4 4 4 1 Leucine Rich Repeat EF-hand_7 PF13499.1 KOO32575.1 - 0.0075 16.3 0.1 0.02 14.9 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO32575.1 - 0.011 15.5 0.1 0.03 14.2 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain LRR_7 PF13504.1 KOO32575.1 - 3 8.4 9.4 10 6.8 0.1 4.3 4 0 0 4 4 4 0 Leucine rich repeat PMI_typeI PF01238.16 KOO32576.1 - 7.8e-39 133.6 0.0 1e-38 133.3 0.0 1.2 1 0 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.14 KOO32576.1 - 0.019 14.6 0.5 18 5.0 0.0 3.5 3 1 0 4 4 4 0 AraC-like ligand binding domain 2OG-FeII_Oxy_3 PF13640.1 KOO32577.1 - 3.7e-07 30.5 0.0 8.2e-07 29.4 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO32577.1 - 0.00055 19.5 0.0 0.001 18.6 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO32577.1 - 0.0013 18.9 0.0 0.0042 17.3 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Shal-type PF11601.3 KOO32577.1 - 3 7.4 5.8 1.2 8.6 0.2 2.8 2 0 0 2 2 2 0 Shal-type voltage-gated potassium channels SelR PF01641.13 KOO32578.1 - 3.4e-29 101.0 0.0 4.3e-26 91.0 0.0 2.1 2 0 0 2 2 2 2 SelR domain zf-ribbon_3 PF13248.1 KOO32578.1 - 5.3e-05 22.2 0.6 0.21 10.8 0.1 2.6 2 0 0 2 2 2 2 zinc-ribbon domain DZR PF12773.2 KOO32578.1 - 0.00043 20.0 0.0 0.0012 18.5 0.0 1.7 1 1 0 1 1 1 1 Double zinc ribbon zinc_ribbon_2 PF13240.1 KOO32578.1 - 0.00073 18.9 4.6 0.045 13.2 0.1 2.5 2 0 0 2 2 2 2 zinc-ribbon domain RRN7 PF11781.3 KOO32578.1 - 0.0055 16.1 0.6 0.12 11.9 0.1 2.3 2 0 0 2 2 2 1 RNA polymerase I-specific transcription initiation factor Rrn7 GFA PF04828.9 KOO32578.1 - 0.0062 16.4 0.0 1.1 9.2 0.0 2.6 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme TF_Zn_Ribbon PF08271.7 KOO32578.1 - 0.008 15.4 0.2 0.88 8.9 0.0 2.4 2 0 0 2 2 2 1 TFIIB zinc-binding Prim_Zn_Ribbon PF08273.7 KOO32578.1 - 0.099 12.7 0.8 4.4 7.4 0.0 2.3 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase DUF678 PF05077.7 KOO32578.1 - 0.14 12.1 0.3 6.5 6.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF678) Nudix_N_2 PF14803.1 KOO32578.1 - 0.14 11.8 2.9 4.9 6.9 0.2 2.6 2 0 0 2 2 2 0 Nudix N-terminal Zn_ribbon_recom PF13408.1 KOO32578.1 - 0.24 11.6 1.5 23 5.3 0.2 2.3 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain DNA_RNApol_7kD PF03604.8 KOO32578.1 - 0.25 10.8 1.0 9.9 5.7 0.1 2.3 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit zf-NADH-PPase PF09297.6 KOO32578.1 - 0.51 9.8 3.5 2.5 7.6 0.2 2.6 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain DUF4440 PF14534.1 KOO32579.1 - 0.0026 17.9 0.1 0.0057 16.8 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_3 PF13474.1 KOO32579.1 - 0.021 14.8 0.0 0.042 13.8 0.0 1.6 1 0 0 1 1 1 0 SnoaL-like domain SBBP PF06739.6 KOO32580.1 - 1.5e-24 85.4 40.5 0.00042 20.0 0.6 7.3 7 0 0 7 7 7 7 Beta-propeller repeat Ponericin PF07442.6 KOO32580.1 - 0.74 9.6 4.7 1.6e+02 2.2 0.0 5.0 6 0 0 6 6 6 0 Ponericin FAD_binding_9 PF08021.6 KOO32580.1 - 5.7 6.9 18.6 75 3.3 0.0 5.9 6 0 0 6 6 6 0 Siderophore-interacting FAD-binding domain Ku_N PF03731.10 KOO32582.1 - 3.9e-14 52.6 0.0 6.3e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_PK_bind PF08785.6 KOO32582.1 - 2.8e-09 36.9 0.0 6.7e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 Ku C terminal domain like Ku PF02735.11 KOO32582.1 - 1e-08 34.8 0.0 1.6e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_C PF03730.9 KOO32582.1 - 3.3e-05 24.3 0.2 0.00068 20.1 0.0 2.5 2 0 0 2 2 2 1 Ku70/Ku80 C-terminal arm VWA PF00092.23 KOO32582.1 - 0.00018 21.3 0.0 0.36 10.5 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain DUF4234 PF14018.1 KOO32583.1 - 0.47 10.2 9.5 1 9.1 0.6 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4234) DUF3112 PF11309.3 KOO32583.1 - 0.49 10.1 3.6 0.61 9.8 0.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3112) YwiC PF14256.1 KOO32583.1 - 1.1 9.3 7.6 1.5 8.9 1.1 2.8 2 1 1 3 3 3 0 YwiC-like protein Ank_2 PF12796.2 KOO32584.1 - 2.2e-36 124.0 8.6 2.8e-12 46.8 0.1 4.3 3 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO32584.1 - 2.4e-29 100.6 14.2 3.4e-11 42.9 0.0 4.8 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.25 KOO32584.1 - 4.6e-27 92.4 11.6 3.7e-07 29.6 0.0 7.1 7 0 0 7 7 7 5 Ankyrin repeat Ank_4 PF13637.1 KOO32584.1 - 5.3e-24 84.1 7.6 3.6e-07 30.5 0.0 6.0 3 2 3 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO32584.1 - 3.8e-15 54.4 5.2 0.0085 16.2 0.0 6.7 7 0 0 7 7 7 5 Ankyrin repeat HNF_C PF09354.5 KOO32584.1 - 0.03 15.4 0.0 0.13 13.4 0.0 2.2 1 1 0 1 1 1 0 HNF3 C-terminal domain EF-hand_6 PF13405.1 KOO32585.1 - 0.00015 21.3 0.2 0.00061 19.4 0.2 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 KOO32585.1 - 0.00046 20.2 0.1 0.00094 19.2 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO32585.1 - 0.001 18.1 0.1 0.0027 16.9 0.1 1.8 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.1 KOO32585.1 - 0.0017 17.5 0.6 0.0058 15.9 0.2 2.0 2 0 0 2 2 2 1 EF hand UPF0197 PF05251.7 KOO32585.1 - 0.0099 16.1 1.9 0.031 14.5 1.3 1.8 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0197) Dicty_REP PF05086.7 KOO32586.1 - 0.56 7.8 7.1 0.85 7.3 4.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein NOA36 PF06524.7 KOO32586.1 - 4 6.5 11.8 10 5.2 8.2 1.6 1 0 0 1 1 1 0 NOA36 protein LRR_4 PF12799.2 KOO32587.1 - 1.6e-16 59.5 0.2 8.2e-08 31.6 0.1 5.3 2 1 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO32587.1 - 3.7e-07 29.2 3.1 3.2 8.1 0.0 6.2 7 0 0 7 7 7 2 Leucine Rich Repeat LRR_8 PF13855.1 KOO32587.1 - 6.1e-07 29.1 0.5 0.00035 20.2 0.3 4.1 5 1 0 5 5 5 1 Leucine rich repeat LRR_6 PF13516.1 KOO32587.1 - 1.1e-06 28.0 0.6 3.2 8.1 0.2 5.7 5 0 0 5 5 5 1 Leucine Rich repeat LRR_9 PF14580.1 KOO32587.1 - 1.4e-05 24.7 0.0 0.038 13.5 0.0 2.4 2 0 0 2 2 2 2 Leucine-rich repeat LRR_7 PF13504.1 KOO32587.1 - 0.00025 20.7 0.2 16 6.2 0.1 5.5 5 0 0 5 5 5 1 Leucine rich repeat Rrp15p PF07890.7 KOO32588.1 - 3.5e-18 65.9 3.2 5.2e-18 65.3 2.2 1.2 1 0 0 1 1 1 1 Rrp15p SAM_1 PF00536.25 KOO32589.1 - 5.8e-06 26.3 0.0 1.1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 KOO32589.1 - 0.033 14.0 0.0 0.055 13.3 0.0 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) ART PF01129.13 KOO32590.1 - 0.00011 21.4 0.0 0.0002 20.5 0.0 1.4 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase YrhK PF14145.1 KOO32590.1 - 0.00022 20.8 20.6 0.096 12.3 2.1 3.5 3 1 0 3 3 3 3 YrhK-like protein ADPrib_exo_Tox PF03496.9 KOO32590.1 - 0.046 12.9 0.0 4.8 6.3 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosyltransferase exoenzyme Mod_r PF07200.8 KOO32591.1 - 5.1e-05 23.2 11.9 0.033 14.1 0.1 2.3 1 1 1 2 2 2 2 Modifier of rudimentary (Mod(r)) protein Alpha-2-MRAP_C PF06401.6 KOO32591.1 - 0.00052 19.9 1.3 0.0009 19.1 0.9 1.5 1 1 0 1 1 1 1 Alpha-2-macroglobulin RAP, C-terminal domain Bacillus_HBL PF05791.6 KOO32591.1 - 0.00076 18.8 3.1 0.16 11.3 0.4 2.7 1 1 1 2 2 2 2 Bacillus haemolytic enterotoxin (HBL) DUF603 PF04645.7 KOO32591.1 - 0.0048 16.8 0.8 0.066 13.1 0.1 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF603 CENP-F_leu_zip PF10473.4 KOO32591.1 - 0.018 14.8 4.2 0.018 14.8 2.9 3.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.6 KOO32591.1 - 0.021 13.5 12.1 0.088 11.4 1.4 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Fib_alpha PF08702.5 KOO32591.1 - 0.031 14.3 5.7 0.56 10.3 0.1 2.6 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family CorA PF01544.13 KOO32591.1 - 0.035 13.1 0.3 0.035 13.1 0.2 1.8 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein IFT57 PF10498.4 KOO32591.1 - 0.18 10.4 7.0 0.25 10.0 4.8 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 COG2 PF06148.6 KOO32591.1 - 0.25 11.1 11.2 1.9 8.3 0.1 3.7 1 1 3 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Ded_cyto PF06920.8 KOO32591.1 - 0.4 9.9 6.5 0.75 9.0 2.5 2.3 2 0 0 2 2 2 0 Dedicator of cytokinesis Atg14 PF10186.4 KOO32591.1 - 0.41 9.5 17.4 0.15 10.9 5.3 2.2 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Mnd1 PF03962.10 KOO32591.1 - 0.59 9.7 15.0 0.23 11.0 3.8 2.4 1 1 1 2 2 2 0 Mnd1 family SlyX PF04102.7 KOO32591.1 - 0.6 10.5 20.6 0.2 12.0 5.2 4.4 2 2 2 4 4 4 0 SlyX Seryl_tRNA_N PF02403.17 KOO32591.1 - 0.93 9.5 15.9 0.27 11.2 1.5 2.6 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Sec8_exocyst PF04048.9 KOO32591.1 - 1.4 8.5 5.9 11 5.5 0.7 2.9 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain BLOC1_2 PF10046.4 KOO32591.1 - 1.7 8.8 6.4 6.9 6.8 0.1 3.3 2 1 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ATG16 PF08614.6 KOO32591.1 - 1.9 8.2 19.4 0.64 9.8 2.1 2.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) TBPIP PF07106.8 KOO32591.1 - 2.3 7.7 10.1 14 5.2 3.8 2.8 1 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) GAS PF13851.1 KOO32591.1 - 3.8 6.6 13.4 1.8 7.7 0.3 2.7 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Syntaxin-6_N PF09177.6 KOO32591.1 - 4.2 7.8 9.8 7 7.1 0.6 3.4 1 1 2 3 3 3 0 Syntaxin 6, N-terminal H-kinase_dim PF02895.9 KOO32591.1 - 7.3 7.0 15.8 10 6.5 5.4 3.7 2 2 1 3 3 3 0 Signal transducing histidine kinase, homodimeric domain DUF1515 PF07439.6 KOO32591.1 - 9.9 6.0 8.7 2.2 8.1 0.7 3.1 1 1 3 4 4 4 0 Protein of unknown function (DUF1515) Ank_4 PF13637.1 KOO32592.1 - 3.1e-20 72.1 2.4 1.1e-08 35.2 0.3 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO32592.1 - 6.5e-19 68.0 0.0 5.4e-10 39.4 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO32592.1 - 4.1e-15 55.4 0.3 1.3e-09 37.9 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO32592.1 - 1.2e-13 50.1 0.0 3.9e-06 26.4 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.1 KOO32592.1 - 1.8e-07 30.7 0.1 0.00054 19.9 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Tcp11 PF05794.8 KOO32593.1 - 8.2e-13 47.8 0.2 7.7e-09 34.7 0.0 2.2 2 0 0 2 2 2 2 T-complex protein 11 UBA PF00627.26 KOO32593.1 - 0.00015 21.4 4.8 0.0017 18.1 1.1 2.8 2 0 0 2 2 2 1 UBA/TS-N domain XPC-binding PF09280.6 KOO32593.1 - 0.00027 20.3 4.2 0.31 10.5 0.0 3.6 4 0 0 4 4 4 2 XPC-binding domain Hexapep PF00132.19 KOO32594.1 - 2.6e-08 33.0 6.6 0.0036 16.7 0.0 4.1 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 KOO32594.1 - 0.00042 19.8 4.6 0.16 11.5 0.1 4.2 2 1 2 4 4 4 2 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.7 KOO32594.1 - 0.038 12.5 0.2 0.049 12.1 0.1 1.3 1 0 0 1 1 1 0 L-fucokinase Filamin PF00630.14 KOO32595.1 - 6.2e-18 65.2 0.0 7.7e-06 26.4 0.0 3.7 3 0 0 3 3 3 3 Filamin/ABP280 repeat VCBS PF13517.1 KOO32596.1 - 4.2e-61 203.1 79.9 2.1e-13 50.4 4.4 6.8 1 1 5 6 6 6 6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO32596.1 - 6.3e-34 114.8 73.8 1e-05 25.0 2.3 7.5 7 0 0 7 7 7 7 FG-GAP repeat GCC2_GCC3 PF07699.8 KOO32596.1 - 1.4e-17 63.0 72.6 1.1e-07 31.3 0.6 9.6 4 2 4 8 8 8 6 GCC2 and GCC3 TcdB_toxin_midN PF12256.3 KOO32596.1 - 3.6e-10 39.5 26.0 0.14 11.6 0.0 7.0 3 2 4 7 7 7 6 Insecticide toxin TcdB middle/N-terminal region NCD3G PF07562.9 KOO32596.1 - 6 6.6 56.3 0.016 14.9 2.5 8.1 6 2 4 10 10 9 0 Nine Cysteines Domain of family 3 GPCR SET PF00856.23 KOO32598.1 - 3.1e-10 40.5 0.0 2.1e-09 37.9 0.0 2.2 1 1 0 1 1 1 1 SET domain Beta-lactamase PF00144.19 KOO32599.1 - 2e-13 50.0 1.1 7.1e-13 48.2 0.8 1.8 1 1 0 1 1 1 1 Beta-lactamase MFS_1 PF07690.11 KOO32600.1 - 2.6e-30 105.3 104.5 2.5e-15 56.0 41.3 4.1 2 2 1 3 3 3 3 Major Facilitator Superfamily Sugar_tr PF00083.19 KOO32600.1 - 2.3e-23 82.5 5.2 2.3e-23 82.5 3.6 4.2 3 1 0 3 3 3 2 Sugar (and other) transporter Pam17 PF08566.5 KOO32600.1 - 3.3 7.3 6.2 13 5.4 0.2 3.1 3 0 0 3 3 3 0 Mitochondrial import protein Pam17 Pkinase PF00069.20 KOO32601.1 - 2.9e-36 124.9 0.0 4.4e-36 124.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.24 KOO32601.1 - 3.6e-16 58.7 0.0 2.8e-15 55.8 0.0 2.1 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.12 KOO32601.1 - 7.2e-15 54.7 0.0 1.2e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO32601.1 - 0.064 12.2 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Hrs_helical PF12210.3 KOO32602.1 - 0.0076 16.4 3.3 0.02 15.1 2.3 1.7 1 0 0 1 1 1 1 Hepatocyte growth factor-regulated tyrosine kinase substrate APG17 PF04108.7 KOO32602.1 - 0.014 14.1 0.4 0.019 13.7 0.3 1.2 1 0 0 1 1 1 0 Autophagy protein Apg17 GAS PF13851.1 KOO32602.1 - 0.052 12.7 4.6 0.077 12.1 3.2 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding TMCO5 PF14992.1 KOO32602.1 - 0.071 12.2 2.7 0.096 11.8 1.9 1.1 1 0 0 1 1 1 0 TMCO5 family DUF3584 PF12128.3 KOO32602.1 - 0.1 9.9 16.0 0.13 9.5 11.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Spc7 PF08317.6 KOO32602.1 - 0.68 8.5 5.5 0.58 8.7 2.8 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein MerR-DNA-bind PF09278.6 KOO32602.1 - 8.8 6.8 15.1 5.6 7.4 3.5 3.0 2 0 0 2 2 2 0 MerR, DNA binding Ank_2 PF12796.2 KOO32603.1 - 1.8e-05 24.9 0.0 5.1e-05 23.5 0.0 1.7 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO32603.1 - 0.00017 22.0 0.0 0.00035 20.9 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.25 KOO32603.1 - 0.0002 21.0 0.0 0.00054 19.6 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.1 KOO32603.1 - 0.0036 17.3 0.0 0.11 12.7 0.0 2.7 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.1 KOO32603.1 - 0.02 15.1 0.0 0.071 13.3 0.0 2.0 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Glycos_transf_3 PF00591.16 KOO32605.1 - 1.6e-87 293.1 4.0 2e-87 292.7 2.8 1.1 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.12 KOO32605.1 - 1.4e-18 66.2 0.2 3.4e-18 64.9 0.1 1.7 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain Sld5 PF05916.6 KOO32606.1 - 0.00012 22.3 0.0 0.00019 21.6 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein EF-hand_1 PF00036.27 KOO32607.1 - 2.3e-54 176.6 16.9 4.7e-06 25.5 0.0 12.7 11 2 2 13 13 13 11 EF hand EF-hand_7 PF13499.1 KOO32607.1 - 1e-52 176.1 20.8 3.1e-10 40.0 0.2 7.2 6 1 1 7 7 7 6 EF-hand domain pair EF-hand_6 PF13405.1 KOO32607.1 - 9.7e-42 137.1 29.0 3.6e-05 23.2 0.0 12.4 11 2 2 13 13 12 9 EF-hand domain EF-hand_5 PF13202.1 KOO32607.1 - 2e-37 124.8 21.4 5.7e-07 28.5 0.0 11.4 11 0 0 11 11 11 7 EF hand EF-hand_8 PF13833.1 KOO32607.1 - 1.6e-25 88.4 18.9 3.7e-05 23.2 0.1 9.4 9 1 1 10 10 10 7 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO32607.1 - 7.8e-06 25.8 3.1 2.5 8.1 0.0 5.3 5 1 1 6 6 6 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOO32607.1 - 0.0013 18.5 1.4 6.6 6.7 0.0 5.3 6 1 0 6 6 6 1 EF-hand domain DUF3872 PF12988.2 KOO32607.1 - 0.0032 17.0 5.1 7.4 6.1 0.1 5.1 3 1 2 5 5 5 1 Domain of unknown function, B. Theta Gene description (DUF3872) p25-alpha PF05517.7 KOO32607.1 - 0.011 16.0 0.1 15 5.7 0.0 3.8 3 2 1 4 4 4 0 p25-alpha EAL PF00563.15 KOO32607.1 - 0.011 15.2 0.3 4.5 6.6 0.0 3.8 2 1 2 4 4 4 0 EAL domain Armet PF10208.4 KOO32607.1 - 0.081 12.5 0.0 0.25 11.0 0.0 1.9 1 0 0 1 1 1 0 Degradation arginine-rich protein for mis-folding SOUL PF04832.7 KOO32608.1 - 1.7e-14 53.7 0.0 2.1e-14 53.4 0.0 1.1 1 0 0 1 1 1 1 SOUL heme-binding protein MFS_1 PF07690.11 KOO32609.1 - 1e-40 139.5 27.2 1e-40 139.5 18.9 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily ZZ PF00569.12 KOO32610.1 - 0.019 14.4 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 Zinc finger, ZZ type Rhodanese PF00581.15 KOO32614.1 - 0.0041 17.4 0.0 0.0067 16.7 0.0 1.4 1 1 0 1 1 1 1 Rhodanese-like domain Phage_integrase PF00589.17 KOO32616.1 - 2.2e-06 27.4 0.0 1.4e-05 24.8 0.0 1.9 2 0 0 2 2 2 1 Phage integrase family DUF383 PF04063.9 KOO32617.1 - 0.06 12.8 0.0 4.3 6.8 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF383) Arm PF00514.18 KOO32617.1 - 2.2 8.2 9.0 28 4.7 0.9 4.2 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat DAGAT PF03982.8 KOO32619.1 - 8e-24 83.8 0.0 1e-23 83.5 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Acyltransferase PF01553.16 KOO32619.1 - 0.079 12.3 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Acyltransferase RTTN_N PF14726.1 KOO32620.1 - 0.01 16.3 0.0 0.024 15.2 0.0 1.6 1 0 0 1 1 1 0 Rotatin, an armadillo repeat protein, centriole functioning EF-hand_1 PF00036.27 KOO32621.1 - 2.6e-18 63.8 12.1 9e-05 21.5 0.4 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO32621.1 - 2.8e-18 64.1 4.1 0.00036 20.1 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO32621.1 - 4.1e-16 58.8 7.2 3.1e-07 30.4 0.6 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO32621.1 - 1.4e-14 52.6 9.6 0.002 17.4 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO32621.1 - 4.9e-11 42.0 9.2 7.4e-05 22.2 2.8 3.4 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO32621.1 - 0.0038 17.2 4.1 2 8.4 0.0 3.7 3 1 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO32621.1 - 0.0076 15.8 0.4 8.1 6.1 0.3 3.1 2 1 1 3 3 3 2 EF hand BNIP2 PF12496.3 KOO32621.1 - 2.1 8.5 5.2 3.9 7.6 3.6 1.8 1 1 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 Glyco_transf_90 PF05686.7 KOO32622.1 - 2e-37 128.8 0.1 2.6e-37 128.4 0.1 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.1 KOO32622.1 - 8.8e-05 22.7 0.0 0.00015 21.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Arm PF00514.18 KOO32623.1 - 2.2e-76 249.3 69.0 2.4e-06 27.1 0.0 22.2 23 1 0 23 23 23 17 Armadillo/beta-catenin-like repeat CAP_GLY PF01302.20 KOO32623.1 - 1.4e-17 63.1 0.1 3.6e-17 61.8 0.1 1.7 1 0 0 1 1 1 1 CAP-Gly domain HEAT_2 PF13646.1 KOO32623.1 - 7.9e-12 45.2 68.6 1.4e-06 28.4 3.9 11.3 3 2 5 10 10 10 5 HEAT repeats V-ATPase_H_N PF03224.9 KOO32623.1 - 1.2e-06 27.8 0.0 0.032 13.3 0.0 5.1 3 3 1 4 4 4 1 V-ATPase subunit H Adaptin_N PF01602.15 KOO32623.1 - 0.0018 16.7 0.3 6.1 5.0 0.0 3.7 4 0 0 4 4 4 2 Adaptin N terminal region Arm_2 PF04826.8 KOO32623.1 - 0.0031 16.6 0.0 18 4.3 0.0 5.0 4 2 1 5 5 5 1 Armadillo-like Proteasom_PSMB PF10508.4 KOO32623.1 - 0.024 12.8 1.2 2.5 6.2 0.2 2.6 2 0 0 2 2 2 0 Proteasome non-ATPase 26S subunit Pkinase PF00069.20 KOO32624.1 - 2.2e-51 174.4 0.0 3.4e-51 173.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32624.1 - 2.3e-38 131.7 0.0 3.2e-38 131.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PDZ PF00595.19 KOO32624.1 - 3.1e-05 24.0 0.3 8.4e-05 22.6 0.2 1.7 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) Kinase-like PF14531.1 KOO32624.1 - 0.00014 20.9 0.0 0.00022 20.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like PDZ_2 PF13180.1 KOO32624.1 - 0.032 14.1 0.0 0.079 12.8 0.0 1.6 1 0 0 1 1 1 0 PDZ domain Peptidase_S28 PF05577.7 KOO32625.1 - 3.2e-10 39.1 0.0 4.3e-10 38.7 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 PPR_2 PF13041.1 KOO32626.1 - 2.8e-19 68.8 0.0 3.5e-11 42.8 0.0 4.0 3 1 1 4 4 4 3 PPR repeat family PPR_3 PF13812.1 KOO32626.1 - 1.5e-18 65.3 2.6 8.4e-05 22.5 0.0 6.1 6 0 0 6 6 6 4 Pentatricopeptide repeat domain PPR PF01535.15 KOO32626.1 - 1e-15 56.5 1.7 0.0026 17.6 0.0 6.4 7 0 0 7 7 7 4 PPR repeat PPR_1 PF12854.2 KOO32626.1 - 2e-14 52.7 2.8 0.00014 21.2 0.0 4.9 5 0 0 5 5 5 3 PPR repeat Ion_trans_2 PF07885.11 KOO32628.1 - 1.1e-28 98.7 17.2 1.7e-14 53.2 0.5 2.7 2 1 0 2 2 2 2 Ion channel Ion_trans PF00520.26 KOO32628.1 - 3.4e-07 29.7 13.2 1.3e-05 24.5 3.8 2.2 2 0 0 2 2 2 2 Ion transport protein EF-hand_1 PF00036.27 KOO32628.1 - 2.6e-05 23.2 1.3 0.041 13.2 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO32628.1 - 6.4e-05 22.1 4.3 0.0037 16.5 0.7 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO32628.1 - 0.00045 20.2 0.3 0.12 12.5 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO32628.1 - 0.0019 17.9 8.3 0.0078 16.0 0.2 3.0 3 0 0 3 3 3 2 EF-hand domain RCC1_2 PF13540.1 KOO32629.1 - 2.9e-47 157.3 34.8 1e-09 37.7 0.3 9.4 9 0 0 9 9 9 8 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.13 KOO32629.1 - 6.1e-29 99.9 21.2 0.0025 17.9 0.4 11.2 10 2 0 10 10 10 7 Regulator of chromosome condensation (RCC1) repeat CBM_X PF06204.6 KOO32629.1 - 0.028 13.8 0.0 11 5.5 0.0 2.7 2 0 0 2 2 2 0 Putative carbohydrate binding domain RRM_6 PF14259.1 KOO32629.1 - 0.15 12.0 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) YebO PF13974.1 KOO32630.1 - 2.3 8.0 7.6 1.4 8.7 3.6 2.2 2 1 0 2 2 2 0 YebO-like protein SHQ1 PF04925.10 KOO32631.1 - 5.2e-48 163.0 0.0 7.8e-48 162.4 0.0 1.1 1 0 0 1 1 1 1 SHQ1 protein TPR_11 PF13414.1 KOO32632.1 - 1.4e-06 27.8 0.0 3e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 TPR repeat TPR_7 PF13176.1 KOO32632.1 - 0.002 17.8 0.0 0.0083 15.8 0.0 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat YukD PF08817.5 KOO32632.1 - 0.0045 17.5 0.0 0.72 10.4 0.0 3.0 3 0 0 3 3 3 1 WXG100 protein secretion system (Wss), protein YukD TPR_2 PF07719.12 KOO32632.1 - 0.005 16.6 0.5 0.04 13.8 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat ubiquitin PF00240.18 KOO32632.1 - 0.02 14.2 0.0 9 5.7 0.0 3.2 3 0 0 3 3 3 0 Ubiquitin family Rad60-SLD PF11976.3 KOO32632.1 - 0.028 14.1 0.0 0.62 9.8 0.0 2.7 2 1 1 3 3 3 0 Ubiquitin-2 like Rad60 SUMO-like TUG-UBL1 PF11470.3 KOO32632.1 - 0.058 13.3 0.3 3.2 7.7 0.1 2.4 2 0 0 2 2 2 0 GLUT4 regulating protein TUG TPR_12 PF13424.1 KOO32632.1 - 0.12 12.3 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Arm PF00514.18 KOO32633.1 - 1.4e-48 161.0 35.3 1.4e-07 31.0 0.6 11.4 12 1 0 12 12 12 9 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 KOO32633.1 - 8.1e-09 34.9 0.0 0.063 12.3 0.0 3.7 2 1 1 4 4 4 3 Armadillo-like Atx10homo_assoc PF09759.4 KOO32633.1 - 3.3e-06 26.7 0.9 2.5 7.8 0.0 4.7 5 0 0 5 5 5 3 Spinocerebellar ataxia type 10 protein domain V-ATPase_H_N PF03224.9 KOO32633.1 - 4.5e-06 25.9 0.0 0.26 10.3 0.0 3.5 1 1 2 3 3 3 2 V-ATPase subunit H HEAT_EZ PF13513.1 KOO32633.1 - 0.0015 18.9 45.9 0.046 14.2 0.2 9.7 7 1 3 10 10 10 5 HEAT-like repeat HEAT PF02985.17 KOO32633.1 - 0.11 12.6 10.3 8 6.8 0.0 6.9 8 0 0 8 8 8 0 HEAT repeat Reo_sigmaC PF04582.7 KOO32633.1 - 0.62 9.1 2.4 0.56 9.3 0.4 1.9 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Syntaxin-6_N PF09177.6 KOO32633.1 - 1 9.7 11.2 0.16 12.3 0.4 3.7 2 1 2 4 4 4 0 Syntaxin 6, N-terminal Spc24 PF08286.6 KOO32633.1 - 7 6.3 10.8 9 6.0 1.0 3.4 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 Ion_trans PF00520.26 KOO32634.1 - 6.7e-161 531.4 25.1 2.1e-47 161.0 0.0 4.6 5 0 0 5 5 5 4 Ion transport protein PKD_channel PF08016.7 KOO32634.1 - 9.8e-06 24.2 8.9 9.8e-06 24.2 6.2 8.0 6 2 2 9 9 9 4 Polycystin cation channel FragX_IP PF05994.6 KOO32635.1 - 8.2e-133 443.9 0.0 1.1e-132 443.5 0.0 1.1 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family DUF1394 PF07159.7 KOO32635.1 - 0.047 12.7 0.0 0.086 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1394) Pkinase PF00069.20 KOO32636.1 - 3.5e-35 121.4 0.0 4.9e-35 120.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32636.1 - 9.2e-32 110.1 0.0 1.3e-31 109.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO32636.1 - 0.00046 19.2 0.0 0.00068 18.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO32636.1 - 0.00074 19.3 0.8 0.022 14.5 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Cellulase-like PF12876.2 KOO32636.1 - 0.041 14.3 0.0 0.089 13.2 0.0 1.5 1 0 0 1 1 1 0 Sugar-binding cellulase-like cobW PF02492.14 KOO32637.1 - 1.6e-39 135.2 0.0 2.3e-39 134.6 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 KOO32637.1 - 3.2e-23 81.2 0.3 1.4e-22 79.2 0.2 2.1 2 1 0 2 2 2 1 Cobalamin synthesis protein cobW C-terminal domain AAA_18 PF13238.1 KOO32637.1 - 0.0099 16.1 0.1 0.018 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain UPF0079 PF02367.12 KOO32637.1 - 0.028 14.0 0.0 0.079 12.5 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 PE_PPE_C PF12484.3 KOO32637.1 - 0.033 15.0 4.7 0.05 14.5 0.8 2.8 2 0 0 2 2 2 0 Polymorphic PE/PPE proteins C terminal ArgK PF03308.11 KOO32637.1 - 0.058 12.1 0.2 0.95 8.1 0.0 2.1 2 0 0 2 2 2 0 ArgK protein AAA_33 PF13671.1 KOO32637.1 - 0.13 12.1 0.1 0.31 10.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain Arch_ATPase PF01637.13 KOO32637.1 - 0.13 11.9 0.0 0.21 11.2 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase AAA_22 PF13401.1 KOO32637.1 - 0.15 12.1 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zip PF02535.17 KOO32637.1 - 7 5.5 10.2 10 4.9 7.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter bZIP_1 PF00170.16 KOO32638.1 - 2.3e-07 30.6 4.2 3.8e-07 29.9 2.9 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 KOO32638.1 - 0.00021 21.0 7.5 0.00021 21.0 5.2 1.6 2 0 0 2 2 2 1 Basic region leucine zipper adh_short PF00106.20 KOO32639.1 - 1.7e-35 122.3 3.0 2.6e-35 121.7 2.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KOO32639.1 - 1.1e-21 77.6 0.9 1.3e-21 77.4 0.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KOO32639.1 - 2e-16 60.1 1.7 2.3e-16 59.9 0.5 1.5 1 1 1 2 2 2 1 KR domain 3HCDH_N PF02737.13 KOO32639.1 - 4.8e-05 23.0 0.4 9.2e-05 22.1 0.3 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.16 KOO32639.1 - 0.0001 21.8 0.5 0.0003 20.2 0.2 1.9 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 KOO32639.1 - 0.0029 16.3 0.1 0.0047 15.6 0.1 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_Gly3P_dh_N PF01210.18 KOO32639.1 - 0.012 15.3 0.6 0.019 14.6 0.1 1.6 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.11 KOO32639.1 - 0.014 14.8 0.3 0.024 14.0 0.2 1.4 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Methyltransf_18 PF12847.2 KOO32639.1 - 0.017 15.6 0.0 0.031 14.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Saccharop_dh PF03435.13 KOO32639.1 - 0.045 12.7 0.5 0.075 12.0 0.3 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase Ldh_1_N PF00056.18 KOO32639.1 - 0.057 13.2 1.9 0.12 12.2 0.2 2.1 2 1 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain Methyltransf_12 PF08242.7 KOO32639.1 - 0.064 13.7 0.1 0.14 12.6 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Pyr_redox PF00070.22 KOO32639.1 - 0.093 13.1 0.6 1 9.8 0.1 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_10 PF13460.1 KOO32639.1 - 0.094 12.7 1.9 0.31 11.0 1.2 2.0 1 1 0 1 1 1 0 NADH(P)-binding ThiF PF00899.16 KOO32639.1 - 0.31 10.8 4.8 0.3 10.8 1.7 2.1 2 1 0 2 2 2 0 ThiF family zf-CW PF07496.10 KOO32640.1 - 2.4e-13 49.5 3.9 7.2e-13 48.0 2.1 2.3 2 0 0 2 2 2 1 CW-type Zinc Finger zf-CXXC PF02008.15 KOO32640.1 - 8.9e-11 41.4 20.9 8.9e-11 41.4 14.5 3.0 4 0 0 4 4 4 1 CXXC zinc finger domain FlxA PF14282.1 KOO32640.1 - 9.7 6.1 13.7 1.1 9.2 6.2 1.8 2 0 0 2 2 2 0 FlxA-like protein Hint PF01079.15 KOO32642.1 - 5.6e-13 48.5 0.2 3.5e-11 42.7 0.1 2.2 1 1 0 1 1 1 1 Hint module DUF444 PF04285.7 KOO32643.1 - 5.6 5.4 7.7 6.7 5.2 5.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF444) TruB_C PF09142.6 KOO32644.1 - 0.15 11.7 3.4 0.11 12.1 0.5 2.2 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal JmjC PF02373.17 KOO32646.1 - 3.9e-05 23.8 0.7 0.00025 21.2 0.0 2.5 2 1 1 3 3 3 1 JmjC domain, hydroxylase Cupin_8 PF13621.1 KOO32646.1 - 0.0034 16.9 0.9 0.0094 15.4 0.3 1.8 1 1 1 2 2 2 1 Cupin-like domain Cupin_4 PF08007.7 KOO32646.1 - 0.016 14.4 0.1 0.032 13.4 0.1 1.5 1 0 0 1 1 1 0 Cupin superfamily protein Collagen PF01391.13 KOO32649.1 - 0.00042 19.8 9.6 0.00042 19.8 6.7 2.1 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) Secretin_N_2 PF07655.8 KOO32649.1 - 2.9 8.3 11.6 5.4 7.4 8.0 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain PRP38 PF03371.10 KOO32651.1 - 1.1e-36 126.0 0.0 1.5e-36 125.6 0.0 1.1 1 0 0 1 1 1 1 PRP38 family Sulfatase PF00884.18 KOO32652.1 - 2.1e-17 63.2 0.0 7e-16 58.2 0.0 2.6 1 1 0 2 2 2 1 Sulfatase Phosphodiest PF01663.17 KOO32652.1 - 8.8e-06 25.2 0.0 1.5e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase BTD PF09270.5 KOO32652.1 - 0.044 13.5 0.0 0.076 12.7 0.0 1.3 1 0 0 1 1 1 0 Beta-trefoil DNA-binding domain PAP_fibrillin PF04755.7 KOO32653.1 - 9.7e-05 22.1 0.0 0.00038 20.2 0.0 1.8 2 0 0 2 2 2 1 PAP_fibrillin Exo_endo_phos PF03372.18 KOO32654.1 - 8.6e-07 29.1 0.0 0.00012 22.1 0.0 2.2 2 0 0 2 2 2 2 Endonuclease/Exonuclease/phosphatase family Exostosin PF03016.10 KOO32656.1 - 1.2e-14 54.0 0.0 1.6e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 Exostosin family DNA_primase_lrg PF04104.9 KOO32657.1 - 8e-74 248.1 0.0 1.1e-73 247.6 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Abhydrolase_5 PF12695.2 KOO32658.1 - 0.021 14.5 0.0 0.058 13.1 0.0 1.7 1 0 0 1 1 1 0 Alpha/beta hydrolase family UPF0227 PF05728.7 KOO32658.1 - 0.11 12.1 0.1 0.26 10.9 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) PPR_2 PF13041.1 KOO32659.1 - 5.9e-18 64.5 0.0 3.2e-09 36.6 0.0 3.0 1 1 2 3 3 3 3 PPR repeat family PPR_3 PF13812.1 KOO32659.1 - 3.1e-14 51.9 1.0 0.0021 18.1 0.0 4.0 4 0 0 4 4 4 3 Pentatricopeptide repeat domain PPR PF01535.15 KOO32659.1 - 1.7e-12 46.4 0.1 0.0073 16.2 0.0 3.2 3 0 0 3 3 3 3 PPR repeat PPR_1 PF12854.2 KOO32659.1 - 7e-11 41.4 0.2 4.7e-05 22.7 0.0 3.2 3 0 0 3 3 3 2 PPR repeat TPR_14 PF13428.1 KOO32659.1 - 0.011 16.3 3.0 1 10.1 0.0 3.7 1 1 3 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.9 KOO32659.1 - 0.095 13.1 6.1 16 6.2 0.3 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Metallophos PF00149.23 KOO32660.1 - 5.6e-09 35.6 0.3 9.2e-09 34.9 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DnaJ PF00226.26 KOO32661.1 - 1.2e-22 79.3 1.6 1.9e-22 78.7 1.1 1.3 1 0 0 1 1 1 1 DnaJ domain MORN PF02493.15 KOO32663.1 - 1.2e-31 106.5 38.8 7.9e-08 31.5 0.2 9.4 9 1 0 9 9 9 7 MORN repeat ECR1_N PF14382.1 KOO32663.1 - 1.1 8.5 8.4 47 3.3 0.0 4.4 4 0 0 4 4 4 0 Exosome complex exonuclease RRP4 N-terminal region TFIIIC_sub6 PF10419.4 KOO32663.1 - 1.2 8.6 6.5 60 3.2 0.1 4.8 5 0 0 5 5 5 0 TFIIIC subunit ubiquitin PF00240.18 KOO32666.1 - 7.3e-05 22.0 0.0 0.0054 16.1 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin family 2OG-FeII_Oxy_5 PF13759.1 KOO32668.1 - 2.7e-08 34.0 0.1 4.7e-07 30.0 0.0 2.4 2 0 0 2 2 2 1 Putative 2OG-Fe(II) oxygenase 2OG-FeII_Oxy_3 PF13640.1 KOO32668.1 - 0.023 15.2 0.0 0.055 13.9 0.0 1.7 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily EMP70 PF02990.11 KOO32670.1 - 3e-176 586.9 30.6 6.2e-99 331.8 22.0 2.1 1 1 1 2 2 2 2 Endomembrane protein 70 Ion_trans PF00520.26 KOO32672.1 - 5.5e-180 593.7 53.7 2.3e-48 164.1 1.1 4.3 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 KOO32672.1 - 5.4e-06 25.0 3.9 5.4e-06 25.0 2.7 8.6 7 2 2 9 9 9 6 Polycystin cation channel Galactosyl_T PF01762.16 KOO32673.1 - 0.00032 20.3 0.0 0.00096 18.7 0.0 1.7 1 1 0 1 1 1 1 Galactosyltransferase Fringe PF02434.11 KOO32673.1 - 0.21 10.7 0.0 0.41 9.8 0.0 1.5 1 1 0 1 1 1 0 Fringe-like Spc7 PF08317.6 KOO32675.1 - 0.016 13.8 6.3 0.011 14.4 3.0 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein WD40 PF00400.27 KOO32676.1 - 2.2e-31 106.5 10.1 4.8e-06 26.2 0.0 7.8 8 0 0 8 8 8 6 WD domain, G-beta repeat CSTF_C PF14304.1 KOO32676.1 - 0.096 11.9 0.6 0.21 10.9 0.4 1.5 1 0 0 1 1 1 0 Transcription termination and cleavage factor C-terminal DUF221 PF02714.10 KOO32677.1 - 1e-13 50.9 10.7 3.6e-12 45.7 7.4 2.3 1 1 0 1 1 1 1 Domain of unknown function DUF221 RRM_6 PF14259.1 KOO32677.1 - 6e-05 22.9 0.0 0.17 11.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOO32677.1 - 0.027 14.0 0.0 0.39 10.3 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO32677.1 - 0.09 12.6 0.0 0.22 11.3 0.0 1.7 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nudc_N PF14050.1 KOO32678.1 - 4.7e-19 68.1 0.6 1.3e-18 66.6 0.4 1.8 1 0 0 1 1 1 1 N-terminal conserved domain of Nudc. CS PF04969.11 KOO32678.1 - 7.9e-15 55.1 0.1 1.6e-14 54.1 0.1 1.6 1 0 0 1 1 1 1 CS domain SR-25 PF10500.4 KOO32678.1 - 0.16 11.4 19.7 0.34 10.3 13.7 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MAT1 PF06391.8 KOO32678.1 - 2.6 7.5 18.2 0.037 13.5 6.5 2.0 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 WD40 PF00400.27 KOO32679.1 - 1.3e-39 132.6 12.8 4e-13 48.7 0.4 3.5 4 0 0 4 4 4 3 WD domain, G-beta repeat PD40 PF07676.7 KOO32679.1 - 7.8e-08 31.8 0.3 0.79 9.4 0.0 3.3 3 0 0 3 3 3 3 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOO32679.1 - 0.00015 21.5 0.4 0.00028 20.6 0.2 1.4 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Gmad1 PF10647.4 KOO32679.1 - 0.0072 15.7 0.1 4.9 6.4 0.0 2.5 1 1 2 3 3 3 2 Lipoprotein LpqB beta-propeller domain DUF3312 PF11768.3 KOO32679.1 - 0.02 13.1 0.0 0.38 8.9 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3312) Proteasome_A_N PF10584.4 KOO32679.1 - 0.49 9.7 1.9 95 2.4 0.1 3.2 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature PAPS_reduct PF01507.14 KOO32680.1 - 1.5e-24 86.7 0.0 2.9e-24 85.8 0.0 1.5 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Thioredoxin PF00085.15 KOO32680.1 - 7.6e-09 35.1 0.1 1.7e-08 34.1 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 KOO32680.1 - 0.0093 16.1 0.1 0.08 13.1 0.0 2.4 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.1 KOO32680.1 - 0.032 13.8 0.0 0.075 12.5 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin Thioredoxin_8 PF13905.1 KOO32680.1 - 0.061 13.4 0.4 6.1 7.0 0.0 3.4 2 1 1 3 3 3 0 Thioredoxin-like Thioredoxin_7 PF13899.1 KOO32680.1 - 0.085 12.8 0.0 0.24 11.4 0.0 1.8 1 0 0 1 1 1 0 Thioredoxin-like PAP_fibrillin PF04755.7 KOO32681.1 - 0.00023 20.9 0.1 0.00064 19.4 0.0 1.6 1 1 1 2 2 2 1 PAP_fibrillin GRA6 PF05084.8 KOO32681.1 - 0.026 14.0 0.4 0.073 12.5 0.2 1.6 2 0 0 2 2 2 0 Granule antigen protein (GRA6) DUF3774 PF12609.3 KOO32682.1 - 0.0095 16.7 0.3 0.051 14.4 0.4 2.1 2 0 0 2 2 2 1 Wound-induced protein PsbQ PF05757.6 KOO32682.1 - 0.24 10.8 4.5 0.05 13.0 0.5 1.7 2 0 0 2 2 2 0 Oxygen evolving enhancer protein 3 (PsbQ) CLASP_N PF12348.3 KOO32683.1 - 2.5e-51 174.2 2.8 1e-31 110.1 0.0 4.8 4 1 0 5 5 5 3 CLASP N terminal HEAT_2 PF13646.1 KOO32683.1 - 5.8e-12 45.7 52.2 0.0045 17.2 0.1 9.2 4 3 5 10 10 10 7 HEAT repeats HEAT PF02985.17 KOO32683.1 - 1.1e-11 43.8 45.3 0.0019 18.1 0.0 12.7 14 0 0 14 14 12 4 HEAT repeat Cnd1 PF12717.2 KOO32683.1 - 5.5e-10 39.3 5.3 0.017 14.9 0.1 7.0 7 2 0 7 7 7 2 non-SMC mitotic condensation complex subunit 1 ParcG PF10274.4 KOO32683.1 - 2.9e-09 37.0 4.9 0.00019 21.3 0.5 5.0 4 1 1 5 5 5 2 Parkin co-regulated protein HEAT_EZ PF13513.1 KOO32683.1 - 5.7e-09 36.1 47.1 0.075 13.5 0.1 12.0 9 3 2 11 11 11 4 HEAT-like repeat Vac14_Fab1_bd PF12755.2 KOO32683.1 - 0.0013 19.0 0.5 17 5.8 0.1 6.0 7 1 1 8 8 8 0 Vacuolar 14 Fab1-binding region DUF1981 PF09324.5 KOO32683.1 - 0.0095 15.4 0.0 0.85 9.1 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1981) MMS19_C PF12460.3 KOO32683.1 - 0.048 12.3 4.1 0.37 9.4 0.0 3.9 4 0 0 4 4 4 0 RNAPII transcription regulator C-terminal Proteasom_PSMB PF10508.4 KOO32683.1 - 0.12 10.6 1.8 0.28 9.4 1.2 1.7 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit Adaptin_N PF01602.15 KOO32683.1 - 0.12 10.6 13.6 5.5 5.1 0.0 5.8 6 1 0 6 6 6 0 Adaptin N terminal region Arm PF00514.18 KOO32683.1 - 5.5 6.9 11.7 66 3.5 0.3 6.1 8 0 0 8 8 8 0 Armadillo/beta-catenin-like repeat DSPc PF00782.15 KOO32684.1 - 3.9e-24 84.7 0.0 4.9e-24 84.4 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KOO32684.1 - 4.7e-05 22.8 0.0 6.6e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.7 KOO32684.1 - 0.041 12.7 0.0 0.051 12.4 0.0 1.1 1 0 0 1 1 1 0 Initiator tRNA phosphoribosyl transferase DUF3368 PF11848.3 KOO32685.1 - 0.071 12.6 0.0 1.7 8.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3368) Y_phosphatase3 PF13350.1 KOO32685.1 - 0.082 13.1 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family Fasciclin PF02469.17 KOO32686.1 - 1.5e-34 118.7 0.0 2.2e-34 118.2 0.0 1.2 1 0 0 1 1 1 1 Fasciclin domain Glyco_transf_21 PF13506.1 KOO32687.1 - 1.7e-09 37.1 0.1 5.2e-09 35.6 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.1 KOO32687.1 - 2.5e-09 37.2 0.0 4.9e-09 36.3 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.21 KOO32687.1 - 0.0012 18.5 0.0 0.0023 17.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.1 KOO32687.1 - 0.0015 18.2 1.9 0.0028 17.4 1.3 1.5 1 0 0 1 1 1 1 Glycosyl transferase family group 2 DUF2590 PF10761.4 KOO32687.1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2590) LRR_8 PF13855.1 KOO32688.1 - 2.7e-07 30.2 0.9 9e-07 28.5 0.7 1.8 1 0 0 1 1 1 1 Leucine rich repeat RRM_5 PF13893.1 KOO32688.1 - 2e-05 24.3 2.6 0.77 9.6 0.1 4.5 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO32688.1 - 3e-05 23.9 0.6 1.3 9.0 0.0 4.0 4 0 0 4 4 4 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOO32688.1 - 9.6e-05 21.9 1.4 1.3 8.6 0.0 3.8 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Exonuc_VII_L PF02601.10 KOO32688.1 - 0.0026 16.9 1.2 0.0026 16.9 0.8 2.1 2 0 0 2 2 2 1 Exonuclease VII, large subunit OmpH PF03938.9 KOO32688.1 - 0.0056 16.6 14.8 0.0056 16.6 10.3 2.2 2 0 0 2 2 1 1 Outer membrane protein (OmpH-like) LRR_4 PF12799.2 KOO32688.1 - 0.0088 15.6 1.2 0.0088 15.6 0.8 2.9 2 2 0 2 2 1 1 Leucine Rich repeats (2 copies) Fzo_mitofusin PF04799.8 KOO32688.1 - 0.04 13.3 9.4 0.093 12.1 6.5 1.6 1 0 0 1 1 1 0 fzo-like conserved region LRR_1 PF00560.28 KOO32688.1 - 0.13 12.3 0.1 0.69 10.1 0.0 2.3 1 0 0 1 1 1 0 Leucine Rich Repeat LRR_6 PF13516.1 KOO32688.1 - 0.26 11.4 3.6 1.1 9.5 0.1 3.7 4 0 0 4 4 2 0 Leucine Rich repeat DUF1282 PF06930.7 KOO32688.1 - 0.38 10.4 3.9 0.85 9.2 1.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1282) Dna2 PF08696.6 KOO32688.1 - 0.4 9.9 2.8 0.78 9.0 1.9 1.4 1 0 0 1 1 1 0 DNA replication factor Dna2 DUF1664 PF07889.7 KOO32688.1 - 0.43 10.3 5.0 1.1 9.0 3.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF342 PF03961.8 KOO32688.1 - 0.75 8.1 10.4 1.3 7.3 7.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Prominin PF05478.6 KOO32688.1 - 1.3 6.4 6.3 2.1 5.8 4.4 1.2 1 0 0 1 1 1 0 Prominin DUF1515 PF07439.6 KOO32688.1 - 2.1 8.2 9.2 10 5.9 0.1 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF1515) V_ATPase_I PF01496.14 KOO32688.1 - 2.4 5.9 6.1 4.1 5.1 4.2 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF445 PF04286.7 KOO32688.1 - 3.1 7.2 11.1 0.25 10.8 3.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF445) Transposase_22 PF02994.9 KOO32688.1 - 3.5 6.0 15.9 0.91 7.9 7.1 2.1 2 0 0 2 2 2 0 L1 transposable element Toxin_52 PF15605.1 KOO32688.1 - 4 7.3 11.2 1.8 8.4 3.4 2.8 2 0 0 2 2 2 0 Putative toxin 52 TRP PF06011.7 KOO32688.1 - 4.2 5.8 5.6 0.78 8.2 0.5 2.1 2 1 1 3 3 3 0 Transient receptor potential (TRP) ion channel HrcA PF01628.16 KOO32688.1 - 4.8 6.7 11.9 2.2 7.8 5.1 2.4 1 1 0 2 2 2 0 HrcA protein C terminal domain DUF106 PF01956.11 KOO32688.1 - 5.7 6.4 5.4 21 4.6 3.7 2.0 1 0 0 1 1 1 0 Integral membrane protein DUF106 Pkinase PF00069.20 KOO32689.1 - 1.3e-29 103.1 0.0 1.6e-29 102.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.1 KOO32689.1 - 0.002 17.1 0.0 0.0031 16.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.12 KOO32689.1 - 0.015 14.3 0.0 0.032 13.3 0.0 1.6 2 0 0 2 2 2 0 Protein tyrosine kinase DUF3287 PF11690.3 KOO32691.1 - 1.5 8.9 5.6 9.9 6.2 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3287) Arm PF00514.18 KOO32692.1 - 4.9e-42 140.3 6.8 1.7e-06 27.6 0.0 7.3 7 1 0 7 7 7 7 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO32692.1 - 1.5e-13 50.8 21.8 2.6e-05 24.3 0.4 4.1 3 1 1 4 4 4 4 HEAT repeats HEAT PF02985.17 KOO32692.1 - 4.3e-06 26.3 3.3 0.019 14.9 0.0 5.0 5 0 0 5 5 5 1 HEAT repeat Op_neuropeptide PF08035.6 KOO32692.1 - 0.0003 20.3 0.0 15 5.2 0.0 4.4 5 0 0 5 5 5 2 Opioids neuropeptide DUF1869 PF08956.5 KOO32692.1 - 0.0048 16.4 0.2 34 4.1 0.0 4.4 5 0 0 5 5 5 0 Domain of unknown function (DUF1869) Arm_2 PF04826.8 KOO32692.1 - 0.0062 15.6 0.0 4.4 6.3 0.0 2.8 1 1 2 3 3 3 2 Armadillo-like DUF2559 PF10832.3 KOO32692.1 - 0.014 15.1 0.0 4.2 7.2 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2559) Alkyl_sulf_dimr PF14863.1 KOO32692.1 - 0.021 15.0 5.6 0.079 13.1 0.4 3.0 1 1 1 3 3 3 0 Alkyl sulfatase dimerisation Succ_CoA_lig PF13607.1 KOO32692.1 - 0.026 14.1 18.5 2.3 7.8 2.4 4.7 1 1 5 6 6 6 0 Succinyl-CoA ligase like flavodoxin domain PMT PF02366.13 KOO32693.1 - 1.6e-42 145.5 9.4 2.7e-42 144.8 6.5 1.3 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Phos_pyr_kin PF08543.7 KOO32694.1 - 3.3e-72 242.6 4.0 4.5e-72 242.2 2.8 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.11 KOO32694.1 - 4e-25 88.7 0.0 8.5e-25 87.7 0.0 1.4 2 0 0 2 2 2 1 TENA/THI-4/PQQC family SDH_sah PF01972.11 KOO32694.1 - 0.0019 17.0 1.1 0.0029 16.4 0.8 1.2 1 0 0 1 1 1 1 Serine dehydrogenase proteinase TPR_10 PF13374.1 KOO32695.1 - 3.9e-37 125.1 21.1 4.6e-12 45.4 1.0 5.1 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_12 PF13424.1 KOO32695.1 - 2.7e-34 116.9 12.9 1.6e-16 59.9 0.7 3.1 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.1 KOO32695.1 - 3.2e-11 42.7 9.7 0.00012 21.6 0.1 3.2 1 1 3 4 4 4 3 TPR repeat TPR_1 PF00515.23 KOO32695.1 - 1.1e-10 40.6 7.2 0.0048 16.4 0.5 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO32695.1 - 4.1e-09 36.8 21.2 2.8e-05 24.6 1.3 3.6 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO32695.1 - 1.4e-07 30.9 14.2 0.0073 16.1 0.3 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO32695.1 - 3e-07 29.7 15.3 0.013 15.2 0.1 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_4 PF07721.9 KOO32695.1 - 6.9e-06 26.0 22.3 0.0067 16.7 0.1 5.9 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO32695.1 - 9.6e-06 25.4 0.6 1.2 9.4 0.1 4.8 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO32695.1 - 2.5e-05 23.7 2.4 0.039 13.7 0.1 4.5 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO32695.1 - 2.5e-05 24.5 19.9 0.042 14.4 0.1 5.0 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO32695.1 - 3.7e-05 23.9 11.9 0.0034 17.6 0.7 3.4 2 2 1 3 3 3 2 Tetratricopeptide repeat Apc3 PF12895.2 KOO32695.1 - 0.00048 20.2 4.8 0.016 15.3 0.0 2.7 1 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF4404 PF14357.1 KOO32695.1 - 0.0079 16.5 0.3 5.6 7.4 0.0 3.2 1 1 3 4 4 4 1 Domain of unknown function (DUF4404) 14-3-3 PF00244.15 KOO32695.1 - 0.05 12.6 1.3 0.064 12.3 0.3 1.6 2 0 0 2 2 2 0 14-3-3 protein TPR_5 PF12688.2 KOO32695.1 - 0.053 13.5 7.1 3.2 7.8 0.3 3.1 1 1 1 2 2 2 0 Tetratrico peptide repeat Vac_Fusion PF02346.11 KOO32695.1 - 0.085 12.2 0.0 3.2 7.2 0.1 2.3 2 0 0 2 2 2 0 Chordopoxvirus fusion protein TPR_6 PF13174.1 KOO32695.1 - 0.14 12.6 9.7 0.26 11.8 0.0 4.7 5 1 0 5 5 5 0 Tetratricopeptide repeat DUF3366 PF11846.3 KOO32695.1 - 0.22 11.4 6.3 3.4 7.4 0.6 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF3366) TPR_9 PF13371.1 KOO32695.1 - 1.3 8.8 8.7 2.4 8.0 2.3 3.4 1 1 2 3 3 3 0 Tetratricopeptide repeat Apc5 PF12862.2 KOO32695.1 - 1.8 8.4 5.0 2.1 8.2 1.6 2.4 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 5 Ank PF00023.25 KOO32696.1 - 2.1e-34 115.5 7.4 1.3e-09 37.3 0.0 4.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_2 PF12796.2 KOO32696.1 - 4.2e-31 107.1 0.2 2e-14 53.6 0.3 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO32696.1 - 3.8e-27 94.1 2.9 8.9e-10 38.8 0.1 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO32696.1 - 3.4e-26 88.6 1.6 4.2e-06 26.4 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.1 KOO32696.1 - 1.2e-25 88.9 5.2 9.9e-09 35.1 0.0 4.3 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Kinesin PF00225.18 KOO32697.1 - 6.9e-77 258.3 0.0 8.6e-77 258.0 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain ACBP PF00887.14 KOO32698.1 - 1.6e-16 59.7 0.0 2.4e-16 59.1 0.0 1.3 1 0 0 1 1 1 1 Acyl CoA binding protein BSD PF03909.12 KOO32698.1 - 6.9e-08 32.1 0.3 1.4e-07 31.1 0.2 1.4 1 0 0 1 1 1 1 BSD domain DUF4496 PF14908.1 KOO32699.1 - 2.7e-15 56.4 0.0 5.3e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4496) DnaJ PF00226.26 KOO32700.1 - 9.9e-06 25.2 0.1 2.5e-05 23.8 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain Ank_2 PF12796.2 KOO32702.1 - 3.9e-34 116.8 3.0 4.9e-19 68.4 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO32702.1 - 1e-26 91.3 14.8 3.7e-06 26.4 0.0 7.7 7 1 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.1 KOO32702.1 - 3.3e-22 78.0 2.9 2.2e-05 24.5 0.1 5.3 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO32702.1 - 4.7e-22 77.9 1.0 1.3e-05 25.5 0.0 4.9 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO32702.1 - 5.9e-22 75.5 1.0 1.2e-05 25.0 0.0 6.9 6 0 0 6 6 6 4 Ankyrin repeat GAS PF13851.1 KOO32704.1 - 0.094 11.8 8.2 0.33 10.1 1.6 2.9 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding DUF4224 PF13986.1 KOO32704.1 - 0.15 11.6 1.6 0.85 9.2 0.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4224) UPF0449 PF15136.1 KOO32704.1 - 0.15 12.2 7.7 6.9 6.9 0.4 3.2 3 0 0 3 3 3 0 Uncharacterised protein family UPF0449 Pol_alpha_B_N PF08418.5 KOO32704.1 - 0.28 10.6 1.8 0.24 10.8 0.1 1.7 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal Sec8_exocyst PF04048.9 KOO32704.1 - 1.2 8.7 3.9 6.7 6.3 0.1 2.8 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain Atx10homo_assoc PF09759.4 KOO32705.1 - 1.4e-07 31.2 0.0 6.3e-07 29.0 0.0 2.1 1 1 1 2 2 2 1 Spinocerebellar ataxia type 10 protein domain Arm PF00514.18 KOO32705.1 - 0.019 14.7 2.7 12 5.8 0.0 5.2 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat DUF937 PF06078.6 KOO32705.1 - 0.56 10.4 5.7 4.6 7.4 0.2 3.2 1 1 1 3 3 3 0 Bacterial protein of unknown function (DUF937) Aldedh PF00171.17 KOO32707.1 - 4.5e-35 120.8 0.0 5.9e-35 120.5 0.0 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family WW PF00397.21 KOO32708.1 - 4.2e-05 23.3 1.4 0.018 14.9 0.2 2.7 2 0 0 2 2 2 2 WW domain zf-HC2 PF13490.1 KOO32708.1 - 0.038 13.9 0.1 0.16 11.9 0.1 2.2 1 0 0 1 1 1 0 Putative zinc-finger TraH PF06122.6 KOO32708.1 - 0.22 10.2 0.0 0.36 9.5 0.0 1.3 1 0 0 1 1 1 0 Conjugative relaxosome accessory transposon protein Tubulin PF00091.20 KOO32709.1 - 8.8e-18 64.9 0.0 9.6e-18 64.7 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.4 KOO32709.1 - 6.6e-05 22.9 0.0 9.2e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain DUF3071 PF11268.3 KOO32712.1 - 0.16 11.7 5.7 0.022 14.5 0.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3071) Methyltransf_2 PF00891.13 KOO32714.1 - 9.3e-18 64.2 0.0 1.6e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_23 PF13489.1 KOO32714.1 - 1.1e-07 31.6 0.0 1.8e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO32714.1 - 2.3e-07 31.4 0.1 6.7e-07 29.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO32714.1 - 1.6e-06 28.5 0.0 4e-06 27.2 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO32714.1 - 0.0065 16.0 0.0 0.017 14.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 KOO32714.1 - 0.007 15.9 0.0 0.014 14.9 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_26 PF13659.1 KOO32714.1 - 0.012 15.6 0.0 0.034 14.1 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 KOO32714.1 - 0.015 15.7 0.0 0.032 14.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 KOO32714.1 - 0.033 13.5 0.4 0.46 9.8 0.0 2.7 2 1 0 2 2 2 0 Methyltransferase small domain Methyltransf_25 PF13649.1 KOO32714.1 - 0.052 13.9 0.0 0.13 12.6 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.13 KOO32714.1 - 0.063 12.3 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family SH3BP5 PF05276.9 KOO32715.1 - 0.00027 20.3 1.4 0.00038 19.8 1.0 1.3 1 0 0 1 1 1 1 SH3 domain-binding protein 5 (SH3BP5) DMAP_binding PF06464.6 KOO32715.1 - 0.013 16.0 1.9 0.22 12.1 0.0 2.4 2 1 0 2 2 2 0 DMAP1-binding Domain IncA PF04156.9 KOO32715.1 - 0.16 11.5 2.7 0.23 11.0 1.9 1.3 1 0 0 1 1 1 0 IncA protein DUF4200 PF13863.1 KOO32715.1 - 0.39 10.6 7.7 1 9.3 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Barttin PF15462.1 KOO32716.1 - 0.045 13.4 0.0 0.047 13.3 0.0 1.1 1 0 0 1 1 1 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) Asp PF00026.18 KOO32718.1 - 2.2e-25 89.5 0.7 4.9e-25 88.4 0.5 1.5 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 KOO32718.1 - 1.5e-05 24.9 2.1 0.0001 22.2 0.1 2.3 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal Peptidase_S15 PF02129.13 KOO32719.1 - 3.3e-37 128.4 0.0 4.5e-37 127.9 0.0 1.1 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.5 KOO32719.1 - 1.7e-19 70.5 0.0 4.4e-19 69.2 0.0 1.6 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Abhydrolase_5 PF12695.2 KOO32719.1 - 0.0065 16.2 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Calc_CGRP_IAPP PF00214.14 KOO32720.1 - 0.0069 16.4 0.2 0.043 13.8 0.1 2.0 2 0 0 2 2 2 1 Calcitonin / CGRP / IAPP family COPI_assoc PF08507.5 KOO32720.1 - 0.011 15.4 0.1 0.023 14.3 0.0 1.5 1 0 0 1 1 1 0 COPI associated protein Na_H_antiport_2 PF13726.1 KOO32720.1 - 0.048 13.5 0.3 0.048 13.5 0.2 1.9 2 0 0 2 2 2 0 Na+-H+ antiporter family SpaB_C PF14028.1 KOO32720.1 - 6.4 6.2 22.3 1.8 8.0 0.5 2.1 1 1 1 2 2 2 0 SpaB C-terminal domain S6PP PF05116.8 KOO32721.1 - 1.4e-16 60.5 0.0 2e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase Hydrolase_3 PF08282.7 KOO32721.1 - 6.7e-08 32.4 0.0 9.4e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase OATP PF03137.15 KOO32721.1 - 0.057 11.4 0.9 0.15 10.0 0.0 2.0 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family NPP1 PF05630.6 KOO32722.1 - 0.1 12.3 1.7 0.13 12.0 1.1 1.3 1 1 0 1 1 1 0 Necrosis inducing protein (NPP1) SprA-related PF12118.3 KOO32722.1 - 0.63 9.3 10.5 0.8 8.9 7.3 1.0 1 0 0 1 1 1 0 SprA-related family DASH_Dad2 PF08654.5 KOO32722.1 - 1.2 9.1 11.7 0.22 11.5 5.5 1.8 2 0 0 2 2 2 0 DASH complex subunit Dad2 FUSC PF04632.7 KOO32722.1 - 2.1 6.6 6.7 2.3 6.5 4.6 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Lge1 PF11488.3 KOO32722.1 - 6.1 7.1 7.9 11 6.3 5.2 1.7 1 1 0 1 1 1 0 Transcriptional regulatory protein LGE1 SBBP PF06739.6 KOO32723.1 - 7.6e-16 57.6 33.5 0.0011 18.6 1.0 7.1 7 0 0 7 7 7 6 Beta-propeller repeat UPF0047 PF01894.12 KOO32723.1 - 0.42 10.4 2.2 69 3.2 0.0 3.9 5 0 0 5 5 5 0 Uncharacterised protein family UPF0047 VCBS PF13517.1 KOO32723.1 - 5.4 7.4 20.5 5.2 7.5 0.6 4.3 4 0 0 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TIR_2 PF13676.1 KOO32724.1 - 5.3e-09 36.1 0.0 1.3e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 TIR domain SSF PF00474.12 KOO32724.1 - 0.00023 19.9 1.3 0.00023 19.9 0.9 1.7 2 0 0 2 2 2 1 Sodium:solute symporter family Peptidase_C1 PF00112.18 KOO32725.1 - 0.0002 21.3 0.2 0.61 9.9 0.0 2.4 2 0 0 2 2 2 2 Papain family cysteine protease Rtf2 PF04641.7 KOO32726.1 - 3.7e-40 137.7 0.0 5e-40 137.3 0.0 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger UBX PF00789.15 KOO32727.1 - 4.6e-05 23.4 0.0 8.6e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 UBX domain FKBP_C PF00254.23 KOO32730.1 - 3.1e-16 59.1 0.0 4.1e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase ShK PF01549.19 KOO32731.1 - 1.3e-21 76.6 33.7 5.8e-08 32.9 2.0 3.3 3 0 0 3 3 3 3 ShK domain-like UPF0640 PF15114.1 KOO32734.1 - 1.4e-09 37.2 0.0 2e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family UPF0640 dsrm PF00035.20 KOO32734.1 - 0.17 12.5 0.2 0.17 12.5 0.1 1.7 2 0 0 2 2 2 0 Double-stranded RNA binding motif PMP1_2 PF08114.6 KOO32734.1 - 1.4 8.4 3.6 2.6 7.5 0.5 2.1 2 0 0 2 2 2 0 ATPase proteolipid family Histone PF00125.19 KOO32735.1 - 1.7e-14 53.6 0.2 2.1e-14 53.4 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 KOO32735.1 - 2.9e-05 24.1 0.1 3.9e-05 23.7 0.1 1.3 1 1 0 1 1 1 1 Kinetochore component CENP-S TAF PF02969.12 KOO32735.1 - 0.0002 21.2 0.2 0.00028 20.7 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.18 KOO32735.1 - 0.00049 20.0 0.1 0.0008 19.4 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 KOO32735.1 - 0.0061 16.2 0.0 0.0085 15.7 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.10 KOO32735.1 - 0.034 13.9 0.0 0.041 13.6 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit CENP-T PF15511.1 KOO32735.1 - 0.035 13.3 0.0 0.035 13.3 0.0 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T DUF996 PF06195.8 KOO32736.1 - 0.013 15.4 0.1 0.016 15.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF996) Psb28 PF03912.9 KOO32737.1 - 8.8e-39 131.8 0.0 1e-38 131.5 0.0 1.1 1 0 0 1 1 1 1 Psb28 protein HC2 PF07382.6 KOO32738.1 - 0.087 12.6 53.6 0.12 12.2 37.1 1.2 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 GHBP PF12772.2 KOO32738.1 - 0.53 9.6 6.2 0.87 8.9 4.3 1.3 1 0 0 1 1 1 0 Growth hormone receptor binding CDC27 PF09507.5 KOO32738.1 - 8.7 5.4 30.5 9.9 5.2 21.2 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 B9-C2 PF07162.6 KOO32739.1 - 6.1e-43 146.5 0.0 7e-43 146.3 0.0 1.0 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein ADH_zinc_N PF00107.21 KOO32740.1 - 1e-19 70.3 0.3 1.8e-19 69.5 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 KOO32740.1 - 2.3e-14 54.3 0.1 1.8e-13 51.4 0.0 2.4 1 1 1 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOO32740.1 - 2.7e-14 52.8 0.3 1e-13 50.9 0.1 2.0 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.20 KOO32740.1 - 0.17 11.7 6.9 0.15 11.9 1.6 2.3 2 0 0 2 2 2 0 short chain dehydrogenase Tho2 PF11262.3 KOO32741.1 - 2e-85 286.4 1.5 3e-85 285.8 1.0 1.3 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.3 KOO32741.1 - 8.7e-28 95.9 0.1 2.6e-27 94.4 0.1 1.9 1 0 0 1 1 1 1 Transcription- and export-related complex subunit p25-alpha PF05517.7 KOO32742.1 - 0.012 15.9 0.0 4.6 7.4 0.0 2.6 2 0 0 2 2 2 0 p25-alpha TPD52 PF04201.10 KOO32743.1 - 0.00055 19.7 11.3 0.11 12.1 0.1 3.6 2 1 1 3 3 3 2 Tumour protein D52 family Atg14 PF10186.4 KOO32743.1 - 0.00071 18.6 6.9 0.00071 18.6 4.8 5.5 3 2 2 5 5 5 2 UV radiation resistance protein and autophagy-related subunit 14 Dzip-like_N PF13815.1 KOO32743.1 - 0.0076 16.0 2.0 0.0076 16.0 1.4 5.5 6 0 0 6 6 6 2 Iguana/Dzip1-like DAZ-interacting protein N-terminal DUF1912 PF08930.5 KOO32743.1 - 3.8 7.6 6.1 22 5.2 0.2 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1912) Reo_sigmaC PF04582.7 KOO32743.1 - 4 6.5 14.8 1.6 7.8 0.6 3.5 4 0 0 4 4 4 0 Reovirus sigma C capsid protein Na_Ca_ex PF01699.19 KOO32746.1 - 2e-26 92.2 26.2 1.2e-13 50.8 3.6 2.6 2 1 0 2 2 2 2 Sodium/calcium exchanger protein Glutaredoxin2_C PF04399.8 KOO32747.1 - 9.3e-23 80.2 0.0 1.5e-22 79.6 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin 2, C terminal domain GST_N_3 PF13417.1 KOO32747.1 - 3.2e-05 24.0 0.0 0.00067 19.8 0.0 2.8 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 KOO32747.1 - 0.012 15.6 0.1 0.036 14.0 0.1 1.8 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain ETC_C1_NDUFA4 PF04800.7 KOO32748.1 - 2.2e-26 91.6 3.9 3.1e-26 91.1 2.7 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region Ribonuclease_T2 PF00445.13 KOO32749.1 - 5.5e-14 52.2 0.0 7.6e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family COPI_assoc PF08507.5 KOO32750.1 - 1.8e-11 43.8 1.8 2.4e-11 43.4 1.3 1.1 1 0 0 1 1 1 1 COPI associated protein Glycos_transf_4 PF00953.16 KOO32750.1 - 0.0081 15.9 1.6 0.012 15.4 1.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 4 Peptidase_M20 PF01546.23 KOO32750.1 - 0.26 10.7 1.5 0.35 10.3 1.0 1.5 1 1 0 1 1 1 0 Peptidase family M20/M25/M40 PGPGW PF09656.5 KOO32750.1 - 1.8 7.8 10.5 25 4.2 7.3 2.6 2 1 0 2 2 2 0 Putative transmembrane protein (PGPGW) RsbRD_N PF14361.1 KOO32751.1 - 0.043 14.2 0.0 0.65 10.4 0.0 2.8 3 0 0 3 3 3 0 RsbT co-antagonist protein rsbRD N-terminal domain PIF1 PF05970.9 KOO32752.1 - 9.9e-14 51.0 0.0 1.8e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.1 KOO32752.1 - 2.6e-11 43.4 0.0 4.8e-10 39.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 KOO32752.1 - 0.0007 18.7 1.0 0.0045 16.0 0.0 2.2 2 0 0 2 2 2 1 Zeta toxin AAA_19 PF13245.1 KOO32752.1 - 0.00078 19.1 0.0 0.0026 17.4 0.0 1.9 1 0 0 1 1 1 1 Part of AAA domain AAA_22 PF13401.1 KOO32752.1 - 0.0051 16.9 0.0 0.013 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain Herpes_Helicase PF02689.9 KOO32752.1 - 0.51 8.0 0.0 1.5 6.4 0.0 1.7 2 0 0 2 2 2 0 Helicase Pkinase PF00069.20 KOO32754.1 - 1.2e-58 198.3 0.0 2.4e-58 197.3 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain cNMP_binding PF00027.24 KOO32754.1 - 1.3e-55 185.2 0.0 1.2e-19 69.9 0.0 3.4 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.12 KOO32754.1 - 2.1e-27 95.8 0.0 4.3e-27 94.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO32754.1 - 0.049 12.5 0.0 0.11 11.4 0.0 1.6 1 0 0 1 1 1 0 Kinase-like Gluconate_2-dh3 PF13618.1 KOO32754.1 - 0.16 12.1 1.6 5.2 7.2 0.0 3.2 3 0 0 3 3 3 0 Gluconate 2-dehydrogenase subunit 3 MgtE_N PF03448.12 KOO32754.1 - 0.16 12.2 1.8 4.3 7.7 0.0 3.3 3 0 0 3 3 3 0 MgtE intracellular N domain DREV PF05219.7 KOO32755.1 - 0.032 13.1 0.0 0.044 12.6 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase DEAD PF00270.24 KOO32756.1 - 2.5e-43 147.5 0.1 2.9e-42 144.0 0.0 2.3 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO32756.1 - 1.3e-26 92.1 0.3 6.4e-26 90.0 0.3 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Coa1 PF08695.5 KOO32756.1 - 9.9e-07 28.2 0.1 2e-06 27.3 0.1 1.4 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 SNF2_N PF00176.18 KOO32756.1 - 0.0044 15.8 0.0 0.0066 15.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 KOO32756.1 - 0.14 12.0 0.0 0.42 10.4 0.0 1.8 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Arm PF00514.18 KOO32757.1 - 8.7e-15 53.9 4.0 4.3e-08 32.6 0.1 4.9 4 1 1 5 5 5 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO32757.1 - 0.00041 20.5 8.0 0.00062 19.9 1.6 3.0 1 1 1 2 2 2 2 HEAT repeats HEAT PF02985.17 KOO32757.1 - 0.0035 17.2 0.2 0.73 10.0 0.0 3.3 3 0 0 3 3 3 1 HEAT repeat HEAT_EZ PF13513.1 KOO32757.1 - 0.63 10.6 6.0 3.8 8.1 0.0 3.8 2 2 2 4 4 4 0 HEAT-like repeat FliT PF05400.8 KOO32757.1 - 1.6 9.1 6.6 2 8.8 0.3 3.0 3 0 0 3 3 3 0 Flagellar protein FliT Rad60-SLD PF11976.3 KOO32759.1 - 9.6e-07 28.4 0.0 2.3e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 KOO32759.1 - 0.011 15.1 0.0 0.026 13.9 0.0 1.7 2 0 0 2 2 2 0 Ubiquitin family LRR_8 PF13855.1 KOO32760.1 - 9.6e-10 38.0 1.0 0.041 13.6 0.1 4.6 2 1 4 6 6 6 5 Leucine rich repeat LRR_1 PF00560.28 KOO32760.1 - 2.2e-08 32.9 2.9 0.62 10.3 0.0 8.5 10 0 0 10 10 10 1 Leucine Rich Repeat LRR_4 PF12799.2 KOO32760.1 - 1.4e-06 27.7 0.9 0.053 13.1 0.0 5.1 6 1 1 7 7 7 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO32760.1 - 0.0064 16.4 0.2 43 4.6 0.0 5.6 8 0 0 8 8 8 0 Leucine Rich repeat LRR_7 PF13504.1 KOO32760.1 - 0.052 13.7 5.5 21 5.8 0.0 5.8 7 0 0 7 7 7 0 Leucine rich repeat 2OG-FeII_Oxy_2 PF13532.1 KOO32762.1 - 1.9e-17 63.7 0.0 2.7e-17 63.2 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Cytochrom_C552 PF02335.10 KOO32763.1 - 2 6.9 10.2 3.3 6.3 7.1 1.3 1 0 0 1 1 1 0 Cytochrome c552 YukC PF10140.4 KOO32764.1 - 0.079 11.5 0.1 0.11 11.1 0.0 1.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Form_Nir_trans PF01226.12 KOO32765.1 - 6.6e-60 202.1 19.0 7.8e-60 201.8 13.2 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter cwf18 PF08315.7 KOO32765.1 - 0.19 12.2 0.0 0.29 11.6 0.0 1.2 1 0 0 1 1 1 0 cwf18 pre-mRNA splicing factor Nucleotid_trans PF03407.11 KOO32767.1 - 3.1e-11 43.4 0.0 5.1e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase DUF3773 PF12608.3 KOO32770.1 - 0.15 12.1 0.4 0.23 11.5 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3773) LRV PF01816.12 KOO32770.1 - 6.6 7.1 6.5 0.99 9.7 0.9 2.3 2 0 0 2 2 2 0 Leucine rich repeat variant Aminotran_4 PF01063.14 KOO32771.1 - 1.1e-26 93.8 0.0 1.9e-20 73.3 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class IV zf-CXXC PF02008.15 KOO32774.1 - 3.9e-12 45.7 19.8 7.5e-12 44.8 13.7 1.5 1 0 0 1 1 1 1 CXXC zinc finger domain LRR_4 PF12799.2 KOO32775.1 - 1.1e-22 79.2 0.3 1.2e-10 40.8 0.1 3.6 3 1 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO32775.1 - 4.4e-13 48.7 2.7 5.6e-06 26.0 0.0 3.3 2 1 1 3 3 3 3 Leucine rich repeat LRR_1 PF00560.28 KOO32775.1 - 1.3e-07 30.6 5.8 2.2 8.6 0.1 6.7 8 0 0 8 8 8 3 Leucine Rich Repeat LRR_7 PF13504.1 KOO32775.1 - 2.8e-06 26.6 10.2 0.51 10.7 0.1 6.4 6 1 0 6 6 6 2 Leucine rich repeat LRR_6 PF13516.1 KOO32775.1 - 3.5e-06 26.5 1.5 30 5.0 0.0 6.2 7 0 0 7 7 7 0 Leucine Rich repeat LRR_9 PF14580.1 KOO32775.1 - 0.019 14.5 0.5 0.36 10.3 0.0 2.3 2 1 0 2 2 2 0 Leucine-rich repeat COG4 PF08318.7 KOO32777.1 - 0.033 12.9 0.0 0.056 12.2 0.0 1.3 1 0 0 1 1 1 0 COG4 transport protein TrbL PF04610.9 KOO32777.1 - 4.2 7.0 7.8 0.76 9.4 0.2 2.5 1 1 0 2 2 2 0 TrbL/VirB6 plasmid conjugal transfer protein PKD_channel PF08016.7 KOO32780.1 - 3e-24 85.2 13.6 9.3e-23 80.3 9.1 2.6 3 0 0 3 3 3 1 Polycystin cation channel Ion_trans PF00520.26 KOO32780.1 - 1.5e-05 24.3 18.7 1.5e-05 24.3 13.0 2.3 2 0 0 2 2 2 1 Ion transport protein Tic22 PF04278.7 KOO32780.1 - 0.015 14.5 0.0 0.031 13.5 0.0 1.4 1 0 0 1 1 1 0 Tic22-like family Phage_Gp23 PF10669.4 KOO32780.1 - 0.12 12.4 0.3 6 6.9 0.0 2.5 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) Glyco_transf_8 PF01501.15 KOO32781.1 - 8.7e-09 35.0 0.0 5.7e-08 32.4 0.0 2.3 1 1 0 1 1 1 1 Glycosyl transferase family 8 BAF1_ABF1 PF04684.8 KOO32782.1 - 0.42 9.4 7.0 0.58 8.9 4.9 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Chorein_N PF12624.2 KOO32783.1 - 5.6e-22 77.4 0.0 7.2e-22 77.1 0.0 1.1 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter T4_deiodinase PF00837.12 KOO32784.1 - 1e-27 96.6 0.1 1.3e-27 96.3 0.0 1.0 1 0 0 1 1 1 1 Iodothyronine deiodinase DUF282 PF03380.9 KOO32784.1 - 0.095 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Caenorhabditis protein of unknown function, DUF282 Glycos_transf_2 PF00535.21 KOO32785.1 - 2.3e-25 89.2 0.0 1.1e-11 44.7 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 KOO32785.1 - 5.2e-14 52.6 1.1 4.9e-13 49.4 0.8 2.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 KOO32785.1 - 8.8e-07 28.2 0.0 0.00014 21.0 0.0 2.9 2 1 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 KOO32785.1 - 0.0091 15.7 0.0 0.028 14.1 0.0 1.9 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.1 KOO32785.1 - 0.019 14.2 0.0 0.038 13.2 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 21 Ion_trans PF00520.26 KOO32786.1 - 1.8e-177 585.6 65.4 5.8e-48 162.7 6.2 4.4 4 0 0 4 4 4 4 Ion transport protein TPR_12 PF13424.1 KOO32786.1 - 2.5e-25 88.1 0.1 1.3e-13 50.7 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.1 KOO32786.1 - 3.5e-22 77.5 9.7 2.9e-07 30.1 0.7 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat PKD_channel PF08016.7 KOO32786.1 - 3.7e-10 38.8 70.5 5.7e-06 25.0 0.3 8.1 7 2 2 9 9 9 6 Polycystin cation channel TPR_14 PF13428.1 KOO32786.1 - 2.5e-05 24.5 3.6 6.3 7.7 0.0 4.8 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO32786.1 - 5.7e-05 23.6 1.3 0.0056 17.3 0.0 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO32786.1 - 8.1e-05 22.1 0.0 0.03 13.9 0.0 2.6 1 1 0 2 2 2 1 TPR repeat TPR_7 PF13176.1 KOO32786.1 - 0.0011 18.6 0.5 8 6.5 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO32786.1 - 0.0016 18.7 0.1 0.46 10.8 0.0 3.1 1 1 3 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO32786.1 - 0.0034 17.1 0.1 7.2 6.7 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO32786.1 - 0.0088 15.6 0.0 15 5.3 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Herpes_UL45 PF05473.7 KOO32786.1 - 2.6 7.3 4.2 3.6 6.9 0.0 3.1 4 0 0 4 4 4 0 UL45 protein CLASP_N PF12348.3 KOO32787.1 - 3.3e-08 33.1 0.0 2e-07 30.6 0.0 2.2 2 0 0 2 2 2 1 CLASP N terminal HEAT PF02985.17 KOO32787.1 - 0.13 12.4 1.2 19 5.6 0.0 3.4 2 0 0 2 2 2 0 HEAT repeat Neur_chan_memb PF02932.11 KOO32788.1 - 0.00013 21.9 3.0 0.00025 21.0 2.1 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF179 PF02622.10 KOO32789.1 - 3.2e-18 65.8 0.2 7.4e-18 64.6 0.1 1.6 1 1 0 1 1 1 1 Uncharacterized ACR, COG1678 Sugar_tr PF00083.19 KOO32791.1 - 1.2e-77 261.4 16.1 2.3e-77 260.4 11.2 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOO32791.1 - 1.2e-14 53.8 62.5 7.5e-13 47.9 27.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KOO32791.1 - 7.8e-06 24.5 15.6 0.0081 14.6 0.0 3.2 2 1 1 3 3 3 2 MFS/sugar transport protein p25-alpha PF05517.7 KOO32792.1 - 0.0034 17.6 0.0 0.13 12.5 0.0 2.5 3 0 0 3 3 3 1 p25-alpha Apolipoprotein PF01442.13 KOO32793.1 - 0.063 12.7 6.5 0.19 11.2 4.5 1.8 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain EamA PF00892.15 KOO32794.1 - 1.3e-06 28.4 30.4 0.00081 19.4 4.7 3.0 3 0 0 3 3 3 2 EamA-like transporter family Neur_chan_memb PF02932.11 KOO32794.1 - 9.2e-06 25.7 0.5 1.6e-05 24.9 0.3 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF914 PF06027.7 KOO32794.1 - 0.00037 19.4 0.1 0.00089 18.1 0.1 1.6 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF914) EmrE PF13536.1 KOO32794.1 - 0.0024 18.0 4.5 0.0024 18.0 3.1 2.9 2 0 0 2 2 2 1 Multidrug resistance efflux transporter DUF4612 PF15389.1 KOO32794.1 - 0.018 15.6 0.0 0.032 14.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4612) TPT PF03151.11 KOO32794.1 - 0.35 10.4 10.3 0.68 9.5 0.6 3.1 3 0 0 3 3 3 0 Triose-phosphate Transporter family Pkinase PF00069.20 KOO32795.1 - 3e-47 160.9 0.0 6.6e-47 159.8 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain ABC_tran PF00005.22 KOO32795.1 - 2.1e-31 109.0 0.0 9.9e-20 71.2 0.0 3.0 2 1 0 2 2 2 2 ABC transporter Pkinase_Tyr PF07714.12 KOO32795.1 - 3.8e-24 85.1 0.0 6.3e-24 84.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase AAA_21 PF13304.1 KOO32795.1 - 8.7e-11 42.3 0.0 0.0042 17.0 0.0 3.2 3 0 0 3 3 3 3 AAA domain SMC_N PF02463.14 KOO32795.1 - 5.9e-06 25.6 0.0 0.018 14.2 0.0 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain Kinase-like PF14531.1 KOO32795.1 - 0.00011 21.3 0.0 0.00036 19.6 0.0 1.8 2 0 0 2 2 2 1 Kinase-like SbcCD_C PF13558.1 KOO32795.1 - 0.00076 19.3 0.0 0.012 15.5 0.0 2.7 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.1 KOO32795.1 - 0.0055 16.2 0.0 0.013 14.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.1 KOO32795.1 - 0.0072 16.6 1.3 0.25 11.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 KOO32795.1 - 0.011 15.8 0.0 0.4 10.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.18 KOO32795.1 - 0.013 15.4 0.1 0.085 12.8 0.0 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_17 PF13207.1 KOO32795.1 - 0.093 13.5 0.8 1.5 9.6 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_15 PF13175.1 KOO32795.1 - 0.093 11.7 0.0 4.7 6.1 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain MobB PF03205.9 KOO32795.1 - 0.097 12.3 0.0 0.33 10.6 0.0 1.9 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B p450 PF00067.17 KOO32796.1 - 9e-59 199.1 0.0 1.1e-58 198.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HCO3_cotransp PF00955.16 KOO32797.1 - 1e-66 225.6 11.8 9.7e-35 120.1 1.9 3.0 1 1 1 2 2 2 2 HCO3- transporter family LRR_6 PF13516.1 KOO32798.1 - 1.2e-56 182.3 28.7 0.00031 20.5 0.0 17.1 18 0 0 18 18 18 13 Leucine Rich repeat LRR_4 PF12799.2 KOO32798.1 - 1.1e-10 40.9 27.5 0.0025 17.3 0.0 9.8 2 2 6 11 11 11 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO32798.1 - 6.2e-08 31.6 3.3 28 5.2 0.0 10.6 11 1 0 11 11 11 0 Leucine Rich Repeat NACHT PF05729.7 KOO32798.1 - 2.2e-06 27.4 0.0 6.8e-06 25.8 0.0 1.9 2 0 0 2 2 2 1 NACHT domain LRR_8 PF13855.1 KOO32798.1 - 1.3e-05 24.8 19.8 0.55 10.0 0.0 7.6 6 3 2 8 8 8 3 Leucine rich repeat AAA_14 PF13173.1 KOO32798.1 - 0.004 17.0 0.0 1.3 8.9 0.0 3.8 2 2 1 3 3 3 1 AAA domain EcKinase PF02958.15 KOO32798.1 - 0.013 14.6 0.0 0.024 13.8 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase RIO1 PF01163.17 KOO32798.1 - 0.078 12.3 0.1 0.18 11.1 0.1 1.6 1 0 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.6 KOO32798.1 - 1.1 7.9 0.0 2 7.1 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 KIP1 PF07765.7 KOO32799.1 - 0.055 13.3 0.4 0.16 11.8 0.0 1.9 2 0 0 2 2 2 0 KIP1-like protein BEX PF04538.7 KOO32799.1 - 2.6 8.3 7.9 1 9.6 2.4 2.4 2 1 0 2 2 2 0 Brain expressed X-linked like family Seryl_tRNA_N PF02403.17 KOO32799.1 - 3 7.8 18.3 0.29 11.1 8.1 2.6 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ECH PF00378.15 KOO32800.1 - 4.9e-10 38.9 0.6 5.5e-10 38.7 0.4 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Peptidase_S49 PF01343.13 KOO32800.1 - 0.043 13.6 1.2 0.072 12.8 0.3 1.7 2 0 0 2 2 2 0 Peptidase family S49 Plectin PF00681.15 KOO32800.1 - 0.058 12.9 0.2 0.25 10.9 0.0 2.1 3 0 0 3 3 3 0 Plectin repeat Arm PF00514.18 KOO32804.1 - 8.2e-27 92.0 17.9 0.00014 21.5 0.0 10.3 9 1 1 10 10 10 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO32804.1 - 9.3e-06 25.8 28.7 0.0057 16.9 2.8 5.2 3 2 2 5 5 5 4 HEAT repeats DUF3220 PF11516.3 KOO32804.1 - 0.006 16.5 0.1 0.013 15.4 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3120) HEAT PF02985.17 KOO32804.1 - 6.8 7.0 0.0 6.8 7.0 0.0 5.6 8 0 0 8 8 8 0 HEAT repeat 2OG-FeII_Oxy PF03171.15 KOO32805.1 - 4.4e-07 30.1 0.0 5.1e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.1 KOO32805.1 - 1.7e-05 25.2 0.1 2.2e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF1765 PF08578.5 KOO32806.1 - 4.9e-06 26.6 0.2 4.9e-06 26.6 0.1 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1765) B56 PF01603.15 KOO32806.1 - 8.4e-05 21.3 0.3 0.00013 20.6 0.2 1.2 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Phage_int_SAM_2 PF12834.2 KOO32808.1 - 0.035 14.4 0.9 34 4.9 0.0 4.3 2 1 5 7 7 7 0 Phage integrase, N-terminal Tubulin PF00091.20 KOO32813.1 - 1.2e-68 231.1 0.0 2.3e-68 230.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 KOO32813.1 - 2.3e-46 156.9 0.1 3.4e-46 156.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 KOO32813.1 - 0.00014 21.8 0.0 0.00032 20.7 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Med25 PF11232.3 KOO32813.1 - 0.096 12.3 0.2 0.29 10.7 0.0 1.8 2 0 0 2 2 2 0 Mediator complex subunit 25 PTOV activation and synapsin 2 SipA PF09052.5 KOO32814.1 - 0.12 10.8 0.8 0.18 10.1 0.5 1.3 1 0 0 1 1 1 0 Salmonella invasion protein A PolyA_pol PF01743.15 KOO32815.1 - 0.06 13.5 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 Poly A polymerase head domain CTP_transf_2 PF01467.21 KOO32815.1 - 0.089 12.8 0.0 0.39 10.7 0.0 2.1 2 0 0 2 2 2 0 Cytidylyltransferase cobW PF02492.14 KOO32816.1 - 3.2e-43 147.2 0.0 4.8e-43 146.6 0.0 1.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.22 KOO32816.1 - 0.00065 19.1 0.3 0.072 12.5 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_19 PF13245.1 KOO32816.1 - 0.0015 18.2 0.2 0.0015 18.2 0.1 2.2 2 1 0 2 2 2 1 Part of AAA domain AAA_33 PF13671.1 KOO32816.1 - 0.0041 16.9 1.1 0.034 14.0 0.8 2.3 1 1 0 1 1 1 1 AAA domain FeoB_N PF02421.13 KOO32816.1 - 0.0054 16.0 0.1 0.011 14.9 0.0 1.5 2 0 0 2 2 2 1 Ferrous iron transport protein B Viral_helicase1 PF01443.13 KOO32816.1 - 0.006 16.1 0.0 0.0088 15.5 0.0 1.2 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.1 KOO32816.1 - 0.012 15.7 0.0 0.026 14.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.1 KOO32816.1 - 0.028 14.4 1.1 0.16 11.9 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain MobB PF03205.9 KOO32816.1 - 0.03 14.0 0.1 0.058 13.0 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_29 PF13555.1 KOO32816.1 - 0.093 12.2 0.0 0.24 10.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain UPF0079 PF02367.12 KOO32816.1 - 0.13 11.8 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Arch_ATPase PF01637.13 KOO32816.1 - 0.14 11.8 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase AAA_14 PF13173.1 KOO32816.1 - 0.15 11.9 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain ArgK PF03308.11 KOO32816.1 - 0.29 9.8 4.4 1.4 7.6 0.1 2.6 3 0 0 3 3 3 0 ArgK protein EF-hand_1 PF00036.27 KOO32817.1 - 0.14 11.4 0.0 0.34 10.3 0.0 1.7 1 0 0 1 1 1 0 EF hand DUF3550 PF12070.3 KOO32819.1 - 4.3e-87 292.9 5.0 2.8e-38 131.9 2.7 3.0 3 0 0 3 3 3 3 Protein of unknown function (DUF3550/UPF0682) CAP_N PF01213.14 KOO32819.1 - 0.044 13.0 3.2 0.09 12.0 2.2 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.6 KOO32819.1 - 0.064 12.6 4.2 0.12 11.7 2.9 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator DUF3040 PF11239.3 KOO32819.1 - 0.22 11.6 0.1 0.22 11.6 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) fn3 PF00041.16 KOO32820.1 - 1.5e-07 31.4 0.0 3.3e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III domain LRR_6 PF13516.1 KOO32822.1 - 3.9e-10 38.7 1.3 0.13 12.4 0.1 4.5 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.2 KOO32822.1 - 0.0015 18.1 0.0 0.0043 16.6 0.0 1.7 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) RNase_T PF00929.19 KOO32823.1 - 2.6e-23 83.1 0.0 3.3e-23 82.7 0.0 1.1 1 0 0 1 1 1 1 Exonuclease Orbi_VP5 PF00901.12 KOO32823.1 - 0.064 11.4 0.0 0.094 10.9 0.0 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 DUF218 PF02698.12 KOO32824.1 - 0.099 12.1 0.1 0.12 11.8 0.1 1.2 1 0 0 1 1 1 0 DUF218 domain Chibby PF14645.1 KOO32824.1 - 0.18 11.6 2.5 1.3 8.9 0.6 2.1 2 0 0 2 2 2 0 Chibby family RRP14 PF15459.1 KOO32824.1 - 1.3 9.1 5.4 0.23 11.5 0.4 2.0 2 0 0 2 2 2 0 60S ribosome biogenesis protein Rrp14 M16C_assoc PF08367.6 KOO32825.1 - 2.9e-42 144.2 0.0 4.4e-42 143.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.16 KOO32825.1 - 2.6e-27 95.6 0.0 6.9e-20 71.4 0.0 3.1 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 KOO32825.1 - 1.3e-06 28.1 0.2 3.9e-06 26.6 0.0 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) EF-hand_1 PF00036.27 KOO32827.1 - 8.2e-31 102.9 14.4 3.1e-09 35.4 2.6 4.2 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO32827.1 - 3e-27 94.0 9.0 2.4e-15 55.8 1.8 3.0 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_7 PF13499.1 KOO32827.1 - 1.8e-25 88.8 5.1 8.2e-12 45.0 1.7 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO32827.1 - 3.1e-23 79.4 7.0 2.5e-05 23.7 0.6 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO32827.1 - 1.6e-22 77.7 10.7 7.9e-06 24.9 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.1 KOO32827.1 - 9.1e-08 31.9 0.0 0.00025 20.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO32827.1 - 1.2e-05 25.2 0.1 0.042 13.8 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO32827.1 - 0.0013 18.4 2.0 1 9.1 0.0 2.6 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand PMBR PF09373.5 KOO32827.1 - 0.13 12.2 0.0 16 5.6 0.0 3.2 4 0 0 4 4 4 0 Pseudomurein-binding repeat Glycos_trans_3N PF02885.12 KOO32827.1 - 0.14 11.7 1.1 1.8 8.2 0.0 2.8 2 1 1 3 3 3 0 Glycosyl transferase family, helical bundle domain SNARE_assoc PF09335.6 KOO32828.1 - 3.1e-22 79.0 9.6 3.1e-22 79.0 6.7 1.6 2 1 0 2 2 2 1 SNARE associated Golgi protein ExoD PF06055.7 KOO32828.1 - 0.11 11.5 0.1 0.11 11.5 0.1 2.5 2 1 1 3 3 3 0 Exopolysaccharide synthesis, ExoD Mg_trans_NIPA PF05653.9 KOO32829.1 - 2.2e-33 115.5 11.7 7.7e-33 113.7 8.1 1.7 1 1 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.15 KOO32829.1 - 1.7e-07 31.3 33.0 2.6e-07 30.7 3.9 3.4 3 1 0 3 3 3 2 EamA-like transporter family EmrE PF13536.1 KOO32829.1 - 9e-07 29.0 5.9 9e-07 29.0 4.1 4.2 2 2 1 4 4 4 1 Multidrug resistance efflux transporter UPF0546 PF10639.4 KOO32829.1 - 0.027 14.2 1.9 0.033 14.0 0.3 1.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0546 Agenet PF05641.7 KOO32830.1 - 4.9e-13 49.0 1.8 4.5e-10 39.5 0.0 3.2 3 1 0 3 3 3 2 Agenet domain zf-CXXC PF02008.15 KOO32831.1 - 6.7e-06 25.8 4.7 6.7e-06 25.8 3.2 2.1 2 0 0 2 2 2 1 CXXC zinc finger domain zf-CW PF07496.10 KOO32831.1 - 0.00078 19.0 0.2 0.0026 17.4 0.2 1.9 1 0 0 1 1 1 1 CW-type Zinc Finger JmjC PF02373.17 KOO32831.1 - 0.009 16.2 0.0 0.023 14.9 0.0 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.24 KOO32831.1 - 0.064 12.9 0.1 0.064 12.9 0.1 2.3 2 0 0 2 2 2 0 PHD-finger Epimerase PF01370.16 KOO32833.1 - 1.5e-14 54.0 0.0 3.5e-14 52.8 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family WWE PF02825.15 KOO32833.1 - 2.7e-13 49.1 0.3 0.0004 19.7 0.0 3.4 2 1 1 3 3 3 3 WWE domain NAD_binding_4 PF07993.7 KOO32833.1 - 1.2e-09 37.4 0.0 1.9e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.1 KOO32833.1 - 9.3e-09 35.5 0.0 1.8e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 KOO32833.1 - 2.1e-08 33.2 0.0 3.2e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family PARP PF00644.15 KOO32833.1 - 0.0058 16.0 0.2 0.086 12.2 0.1 2.1 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain LRR_8 PF13855.1 KOO32836.1 - 1.3e-05 24.8 0.1 2.4e-05 23.9 0.1 1.4 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.2 KOO32836.1 - 0.0018 17.8 0.0 0.0042 16.6 0.0 1.6 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO32836.1 - 0.0019 18.0 0.0 0.25 11.5 0.0 3.2 3 0 0 3 3 3 1 Leucine Rich repeat LRR_1 PF00560.28 KOO32836.1 - 0.0038 17.0 0.2 0.051 13.6 0.0 2.8 2 0 0 2 2 2 1 Leucine Rich Repeat TRP PF06011.7 KOO32836.1 - 0.0057 15.2 0.8 0.0057 15.2 0.6 3.1 2 1 1 3 3 3 1 Transient receptor potential (TRP) ion channel LRR_7 PF13504.1 KOO32836.1 - 0.093 12.9 0.3 4.8 7.8 0.0 3.4 4 0 0 4 4 4 0 Leucine rich repeat Mpv17_PMP22 PF04117.7 KOO32837.1 - 8.4e-15 54.1 2.5 8.4e-15 54.1 1.7 1.8 2 0 0 2 2 2 1 Mpv17 / PMP22 family EI24 PF07264.6 KOO32837.1 - 0.67 9.3 5.7 1.1 8.6 4.0 1.4 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) TPR_12 PF13424.1 KOO32838.1 - 2e-08 34.0 1.7 2e-08 34.0 1.2 4.8 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.1 KOO32838.1 - 0.0069 16.2 16.3 0.046 13.6 1.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat NB-ARC PF00931.17 KOO32838.1 - 0.011 14.6 0.0 0.021 13.6 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain DUF4131 PF13567.1 KOO32838.1 - 0.05 13.0 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF3995 PF13160.1 KOO32838.1 - 5.7 6.9 15.1 1.1 9.3 6.3 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3995) Leo1 PF04004.8 KOO32839.1 - 3.2e-39 134.3 2.4 3.2e-39 134.3 1.7 1.6 2 0 0 2 2 2 1 Leo1-like protein GrpB PF04229.9 KOO32839.1 - 0.012 15.3 2.2 0.021 14.5 1.5 1.4 1 0 0 1 1 1 0 GrpB protein DUF4522 PF15022.1 KOO32840.1 - 0.13 11.9 1.0 0.23 11.1 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4522) UCH PF00443.24 KOO32844.1 - 1.7e-37 129.0 0.0 2.2e-37 128.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 KOO32844.1 - 7e-12 45.2 1.7 1.6e-11 44.1 1.1 1.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.1 KOO32844.1 - 0.00044 19.7 0.1 0.027 13.9 0.0 2.0 1 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase zf-C3HC4_2 PF13923.1 KOO32846.1 - 1.1e-09 38.1 14.0 1.8e-09 37.4 9.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO32846.1 - 2.5e-09 36.6 14.5 4.1e-09 35.9 10.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO32846.1 - 5.9e-08 32.2 13.0 9.4e-08 31.6 9.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 KOO32846.1 - 1.8e-07 30.9 12.8 3e-07 30.1 8.9 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 KOO32846.1 - 2.8e-07 30.1 13.6 4.6e-07 29.4 9.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 KOO32846.1 - 5.2e-07 29.3 13.4 8.6e-07 28.6 9.3 1.4 1 0 0 1 1 1 1 Ring finger domain U-box PF04564.10 KOO32846.1 - 5.9e-07 29.3 0.1 1.7e-06 27.8 0.1 1.7 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO32846.1 - 5.1e-05 22.7 7.1 9.1e-05 21.9 4.9 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 KOO32846.1 - 5.8e-05 22.7 10.3 0.00012 21.6 7.2 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_6 PF14835.1 KOO32846.1 - 0.00012 21.7 5.5 0.00021 20.9 3.8 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_4 PF14570.1 KOO32846.1 - 0.0062 16.0 16.3 0.041 13.4 11.6 2.0 1 1 1 2 2 2 1 RING/Ubox like zinc-binding domain zf-MIZ PF02891.15 KOO32846.1 - 0.0083 15.6 12.3 0.013 15.0 8.6 1.3 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Apc11 PF12861.2 KOO32846.1 - 0.058 13.2 3.2 0.1 12.4 2.2 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 KOO32846.1 - 0.29 11.2 10.8 1.2 9.2 7.5 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger zf-UDP PF14569.1 KOO32846.1 - 0.57 9.9 5.4 1.2 8.9 3.7 1.4 1 0 0 1 1 1 0 Zinc-binding RING-finger GST_N_3 PF13417.1 KOO32848.1 - 1.3e-18 66.9 0.0 3.6e-18 65.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 KOO32848.1 - 6.9e-13 48.4 0.0 1.4e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KOO32848.1 - 1.9e-10 40.5 0.3 5.3e-10 39.0 0.2 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 KOO32848.1 - 4.2e-08 33.0 0.0 8.2e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 KOO32848.1 - 2.3e-06 27.9 0.0 5.5e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.19 KOO32848.1 - 0.0031 17.4 0.0 0.0057 16.6 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin DUF4081 PF13312.1 KOO32848.1 - 0.049 13.5 0.4 0.13 12.2 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4081) GST_N PF02798.15 KOO32848.1 - 0.058 13.5 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain rve PF00665.21 KOO32849.1 - 6.5e-05 23.0 0.1 0.00021 21.3 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain Iso_dh PF00180.15 KOO32850.1 - 5.3e-117 390.6 0.0 6e-117 390.4 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Laminin_I PF06008.9 KOO32851.1 - 0.00041 19.7 4.7 0.00041 19.7 3.2 1.6 2 0 0 2 2 2 1 Laminin Domain I Fib_alpha PF08702.5 KOO32851.1 - 0.016 15.3 2.3 0.016 15.3 1.6 1.4 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Cytadhesin_P30 PF07271.6 KOO32851.1 - 0.048 12.9 3.1 0.085 12.1 2.2 1.4 1 0 0 1 1 1 0 Cytadhesin P30/P32 DUF507 PF04368.8 KOO32851.1 - 0.084 12.5 1.8 5.4 6.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF507) Pol_alpha_B_N PF08418.5 KOO32851.1 - 0.6 9.5 5.0 0.79 9.2 3.5 1.4 1 1 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal DUF972 PF06156.8 KOO32851.1 - 8.8 6.7 9.1 0.28 11.5 0.4 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF972) PP2C PF00481.16 KOO32852.1 - 1.6e-15 57.2 0.0 1.8e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOO32852.1 - 8.9e-05 22.2 0.1 0.00011 21.9 0.1 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) LRR_6 PF13516.1 KOO32853.1 - 2.8e-39 128.7 2.7 7.5e-05 22.4 0.0 9.0 8 0 0 8 8 8 8 Leucine Rich repeat LRR_4 PF12799.2 KOO32853.1 - 0.013 15.0 10.5 4.9 6.8 0.0 5.3 3 3 2 5 5 5 0 Leucine Rich repeats (2 copies) Skp1 PF01466.14 KOO32853.1 - 0.033 14.1 0.0 0.13 12.2 0.0 2.1 1 0 0 1 1 1 0 Skp1 family, dimerisation domain SpoU_sub_bind PF08032.7 KOO32853.1 - 0.11 12.6 6.9 11 6.2 0.1 4.6 4 1 1 5 5 5 0 RNA 2'-O ribose methyltransferase substrate binding Bromo_TP PF07524.8 KOO32854.1 - 0.11 12.1 0.0 0.31 10.8 0.0 1.7 1 0 0 1 1 1 0 Bromodomain associated LHH PF14411.1 KOO32854.1 - 0.13 12.5 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 A nuclease of the HNH/ENDO VII superfamily with conserved LHH SAP PF02037.22 KOO32855.1 - 5.3e-06 25.8 0.1 9e-06 25.0 0.1 1.4 1 0 0 1 1 1 1 SAP domain AP2 PF00847.15 KOO32855.1 - 0.032 14.3 0.2 0.032 14.3 0.2 5.5 5 1 0 5 5 5 0 AP2 domain PDZ PF00595.19 KOO32856.1 - 5.4e-05 23.2 0.2 0.0001 22.4 0.1 1.6 1 1 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO32856.1 - 0.00015 21.5 0.2 0.00025 20.8 0.1 1.4 1 1 0 1 1 1 1 PDZ domain Smr PF01713.16 KOO32857.1 - 4.5e-09 36.3 0.9 9.4e-09 35.3 0.6 1.6 1 0 0 1 1 1 1 Smr domain IQ PF00612.22 KOO32858.1 - 6.7e-05 22.1 7.9 0.034 13.7 0.0 3.4 3 0 0 3 3 3 2 IQ calmodulin-binding motif PDZ PF00595.19 KOO32858.1 - 0.015 15.4 0.0 0.038 14.1 0.0 1.7 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) Glyco_transf_20 PF00982.16 KOO32859.1 - 3.3e-134 447.9 0.0 2.1e-133 445.2 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 KOO32859.1 - 3.4e-58 196.3 0.0 1.3e-24 86.4 0.0 4.2 3 1 1 4 4 4 4 Trehalose-phosphatase RVT_2 PF07727.9 KOO32862.1 - 3.1e-28 98.3 0.0 5e-28 97.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KOO32862.1 - 4.1e-09 36.5 0.1 1.7e-08 34.5 0.1 2.1 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.1 KOO32862.1 - 1.6e-06 27.6 0.0 4.3e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 GAG-pre-integrase domain Peptidase_M50 PF02163.17 KOO32862.1 - 1.9 7.4 5.0 0.26 10.1 0.3 1.8 2 0 0 2 2 2 0 Peptidase family M50 Sel1 PF08238.7 KOO32863.1 - 1.4e-74 244.8 79.3 8.4e-08 32.6 1.0 12.2 12 0 0 12 12 12 11 Sel1 repeat U-box PF04564.10 KOO32863.1 - 3e-16 59.1 0.0 4.4e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO32863.1 - 0.00016 21.1 0.0 0.00037 19.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit gag-asp_proteas PF13975.1 KOO32863.1 - 3.2 7.6 17.6 17 5.3 0.1 6.6 9 0 0 9 9 9 0 gag-polyprotein putative aspartyl protease EF-hand_7 PF13499.1 KOO32864.1 - 2.6e-25 88.3 12.3 6.2e-10 39.0 0.8 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO32864.1 - 1.9e-24 83.0 12.2 1.1e-05 24.3 0.5 6.3 6 0 0 6 6 6 5 EF hand EF-hand_6 PF13405.1 KOO32864.1 - 9.9e-23 77.9 12.2 3e-06 26.6 0.0 6.4 6 0 0 6 6 6 4 EF-hand domain EF-hand_8 PF13833.1 KOO32864.1 - 5.9e-16 57.8 8.6 1.1e-06 28.1 0.5 4.5 3 1 2 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO32864.1 - 3e-14 51.6 15.4 0.00098 18.3 0.5 4.9 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.1 KOO32864.1 - 0.0024 17.7 0.2 3.9 7.4 0.0 3.7 5 0 0 5 5 5 1 EF-hand domain EF-hand_4 PF12763.2 KOO32864.1 - 0.17 11.5 3.1 25 4.6 0.1 3.8 3 1 1 4 4 4 0 Cytoskeletal-regulatory complex EF hand TIG PF01833.19 KOO32865.1 - 5.8e-99 324.2 75.5 6.8e-09 35.6 0.0 23.7 22 3 0 22 22 22 19 IPT/TIG domain DUF3251 PF11622.3 KOO32865.1 - 0.38 10.1 0.0 1.3 8.3 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3251) Vpu PF00558.14 KOO32865.1 - 1.3 8.6 0.6 2.3 7.8 0.4 1.3 1 0 0 1 1 1 0 Vpu protein PRKCSH_1 PF13015.1 KOO32865.1 - 2.6 7.4 0.0 5.2 6.5 0.0 1.4 1 0 0 1 1 1 0 Glucosidase II beta subunit-like protein Myosin_head PF00063.16 KOO32866.1 - 6.9e-180 599.4 0.0 8.2e-180 599.2 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) RUN PF02759.14 KOO32866.1 - 1.7e-19 69.8 0.1 5.4e-19 68.2 0.1 1.9 1 0 0 1 1 1 1 RUN domain AAA_16 PF13191.1 KOO32866.1 - 0.025 14.5 0.1 0.086 12.8 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.1 KOO32866.1 - 0.034 14.9 0.2 0.58 10.9 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.1 KOO32866.1 - 0.037 14.1 0.5 0.19 11.8 0.0 2.4 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.1 KOO32866.1 - 0.076 13.3 0.1 0.61 10.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain Sad1_UNC PF07738.8 KOO32867.1 - 1e-24 86.8 0.0 1.4e-24 86.3 0.0 1.2 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal VirC1 PF07015.6 KOO32867.1 - 0.0076 15.3 0.2 0.013 14.6 0.1 1.3 1 0 0 1 1 1 1 VirC1 protein F5_F8_type_C PF00754.20 KOO32867.1 - 0.013 15.3 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 F5/8 type C domain Pcc1 PF09341.5 KOO32869.1 - 0.0011 18.9 14.0 4 7.5 0.1 7.0 5 1 1 6 6 6 2 Transcription factor Pcc1 Not3 PF04065.10 KOO32869.1 - 0.011 14.9 0.1 0.022 14.0 0.0 1.3 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component IstB_IS21_ATP PF08483.6 KOO32869.1 - 0.21 11.3 3.6 5.7 6.7 0.2 2.6 2 0 0 2 2 2 0 IstB-like ATP binding N-terminal WD-3 PF09765.4 KOO32870.1 - 1.4e-40 139.4 0.0 1.7e-40 139.1 0.0 1.0 1 0 0 1 1 1 1 WD-repeat region FANCL_C PF11793.3 KOO32870.1 - 1.4e-22 79.4 6.5 2e-22 78.8 4.5 1.2 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_2 PF13639.1 KOO32870.1 - 2.2e-06 27.3 7.6 3.7e-06 26.6 5.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KOO32870.1 - 0.0053 16.8 1.5 0.01 15.9 1.0 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger RINGv PF12906.2 KOO32870.1 - 0.0055 16.7 3.5 0.011 15.8 2.4 1.5 1 0 0 1 1 1 1 RING-variant domain zf-PHD-like PF15446.1 KOO32870.1 - 0.022 14.0 2.9 0.033 13.4 2.0 1.2 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain PHD PF00628.24 KOO32870.1 - 0.032 13.9 8.1 0.06 13.0 5.6 1.5 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.1 KOO32870.1 - 0.033 13.9 1.4 0.033 13.9 0.9 1.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-C3HC4_2 PF13923.1 KOO32870.1 - 0.06 13.3 4.4 0.13 12.2 3.1 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) SpoIIE PF07228.7 KOO32871.1 - 1.5e-07 31.3 0.1 5.6e-07 29.4 0.0 2.0 2 1 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) rve PF00665.21 KOO32872.1 - 0.00068 19.7 0.0 0.0015 18.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Ion_trans PF00520.26 KOO32873.1 - 1.3e-13 50.6 3.7 2.4e-13 49.8 2.6 1.4 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO32873.1 - 3.8e-10 39.3 1.3 3.8e-10 39.3 0.9 2.0 2 0 0 2 2 2 1 Ion channel Ion_trans_N PF08412.5 KOO32873.1 - 0.018 14.3 0.5 0.067 12.4 0.0 2.3 3 0 0 3 3 3 0 Ion transport protein N-terminal His_Phos_1 PF00300.17 KOO32874.1 - 1.5e-21 77.1 0.0 3.6e-21 75.9 0.0 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Ras PF00071.17 KOO32875.1 - 2.7e-55 186.1 0.7 4.3e-55 185.5 0.5 1.3 1 0 0 1 1 1 1 Ras family Kelch_3 PF13415.1 KOO32875.1 - 2.2e-33 113.6 10.0 5.1e-11 42.4 0.1 7.7 7 1 0 7 7 7 4 Galactose oxidase, central domain Kelch_4 PF13418.1 KOO32875.1 - 2.5e-33 113.5 4.1 1.5e-07 31.0 0.0 7.9 6 1 1 7 7 7 6 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO32875.1 - 2.3e-22 78.5 5.9 9.2e-05 22.2 0.1 6.2 6 0 0 6 6 6 4 Kelch motif Miro PF08477.8 KOO32875.1 - 8.9e-18 64.9 0.4 3.1e-17 63.1 0.1 2.0 1 1 1 2 2 2 1 Miro-like protein Kelch_1 PF01344.20 KOO32875.1 - 2.1e-16 59.2 0.0 0.017 14.6 0.0 5.0 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.10 KOO32875.1 - 3.1e-16 58.4 9.5 0.0023 17.6 0.0 7.4 8 1 0 8 8 8 4 Kelch motif Kelch_6 PF13964.1 KOO32875.1 - 3e-15 55.6 1.1 0.0021 18.1 0.0 6.4 6 1 0 6 6 6 3 Kelch motif Arf PF00025.16 KOO32875.1 - 1.5e-13 50.3 0.2 2.9e-13 49.4 0.1 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family RAG2 PF03089.9 KOO32875.1 - 2.7e-08 32.9 0.6 0.093 11.4 0.1 3.2 3 0 0 3 3 3 3 Recombination activating protein 2 Gtr1_RagA PF04670.7 KOO32875.1 - 3.6e-07 29.5 0.1 5.4e-07 29.0 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 KOO32875.1 - 0.0014 17.8 0.1 0.0028 16.8 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 KOO32875.1 - 0.0018 18.1 0.0 0.0033 17.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.13 KOO32875.1 - 0.0021 17.1 0.1 0.0041 16.1 0.1 1.3 1 0 0 1 1 1 1 Septin GTP_EFTU PF00009.22 KOO32875.1 - 0.0043 16.5 0.8 0.02 14.3 0.6 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.1 KOO32875.1 - 0.0052 16.7 0.0 0.011 15.7 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.7 KOO32875.1 - 0.015 14.9 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA PF00004.24 KOO32875.1 - 0.037 14.2 0.1 0.11 12.7 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.1 KOO32875.1 - 0.047 13.2 0.2 0.14 11.7 0.1 1.7 1 1 1 2 2 2 0 AAA domain DUF1302 PF06980.6 KOO32875.1 - 0.052 12.1 0.0 0.081 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1302) AAA_22 PF13401.1 KOO32875.1 - 0.057 13.5 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 KOO32875.1 - 0.1 11.7 0.1 1.5 7.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 KOO32876.1 - 0.0025 17.9 0.0 0.55 10.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain Torsin PF06309.6 KOO32876.1 - 0.0086 15.9 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 Torsin AAA_17 PF13207.1 KOO32876.1 - 0.0096 16.7 0.0 0.023 15.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 KOO32876.1 - 0.011 15.1 0.0 0.011 15.1 0.0 2.2 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA PF00004.24 KOO32876.1 - 0.026 14.7 0.0 0.42 10.8 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO32876.1 - 0.027 14.4 0.0 0.21 11.5 0.0 2.4 3 0 0 3 3 3 0 AAA ATPase domain RuvB_N PF05496.7 KOO32876.1 - 0.077 12.0 0.0 0.15 11.0 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_10 PF12846.2 KOO32876.1 - 0.1 12.0 0.0 0.23 10.8 0.0 1.5 2 0 0 2 2 2 0 AAA-like domain Bacteriocin_IIc PF10439.4 KOO32876.1 - 2.3 8.3 13.3 7.6 6.7 9.2 1.9 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Ribosomal_S21 PF01165.15 KOO32877.1 - 3.2e-09 36.0 9.0 7e-09 35.0 6.2 1.6 1 1 0 1 1 1 1 Ribosomal protein S21 SHIPPO-rpt PF07004.7 KOO32878.1 - 0.0087 16.9 2.6 0.015 16.1 0.2 2.7 3 1 0 3 3 3 1 Sperm-tail PG-rich repeat BTB PF00651.26 KOO32879.1 - 6.2e-09 35.8 0.0 1.4e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain START PF01852.14 KOO32881.1 - 0.036 13.4 0.0 0.046 13.0 0.0 1.1 1 0 0 1 1 1 0 START domain MgtE_N PF03448.12 KOO32881.1 - 1.9 8.8 5.0 1 9.7 1.1 2.0 2 0 0 2 2 2 0 MgtE intracellular N domain CTNNBL PF08216.6 KOO32882.1 - 5.2e-31 106.4 0.2 1.2e-30 105.3 0.1 1.6 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear Mo25 PF08569.6 KOO32882.1 - 0.094 11.7 0.1 1.5 7.8 0.1 2.1 1 1 1 2 2 2 0 Mo25-like DUF3341 PF11821.3 KOO32883.1 - 0.0097 15.3 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3341) GST_N_3 PF13417.1 KOO32884.1 - 1.3e-19 70.1 0.0 3.6e-19 68.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 KOO32884.1 - 2.2e-12 46.7 0.0 4.1e-12 45.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 KOO32884.1 - 2.4e-07 30.8 0.0 4.7e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KOO32884.1 - 5e-05 23.0 0.1 0.00014 21.6 0.1 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 KOO32884.1 - 8e-05 23.0 0.2 0.00035 20.9 0.0 2.1 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.19 KOO32884.1 - 0.0011 18.9 0.0 0.0021 18.0 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin GST_C PF00043.20 KOO32884.1 - 0.026 14.4 0.0 0.051 13.5 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF1344 PF07076.6 KOO32885.1 - 0.055 13.0 0.0 5.3 6.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1344) 2OG-FeII_Oxy_3 PF13640.1 KOO32886.1 - 9.6e-10 38.8 0.0 1.9e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Oxygenase-NA PF09859.4 KOO32886.1 - 0.0054 16.0 0.0 0.0089 15.3 0.0 1.3 1 0 0 1 1 1 1 Oxygenase, catalysing oxidative methylation of damaged DNA 2OG-FeII_Oxy_4 PF13661.1 KOO32886.1 - 0.083 12.5 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Tet_JBP PF12851.2 KOO32886.1 - 0.16 11.2 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 Oxygenase domain of the 2OGFeDO superfamily MMR_HSR1 PF01926.18 KOO32887.1 - 8.3e-08 32.1 0.0 1.8e-07 31.0 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 KOO32887.1 - 4.3e-06 26.0 0.0 8.3e-06 25.0 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 KOO32887.1 - 0.0028 16.9 0.0 0.0051 16.0 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 KOO32887.1 - 0.0029 17.4 0.0 0.028 14.2 0.0 2.1 2 0 0 2 2 2 1 Dynamin family AAA_16 PF13191.1 KOO32887.1 - 0.01 15.8 0.1 0.041 13.8 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Ribosomal_L30 PF00327.15 KOO32887.1 - 0.025 14.1 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L30p/L7e ABC_tran PF00005.22 KOO32887.1 - 0.027 14.7 0.0 0.061 13.6 0.0 1.6 1 0 0 1 1 1 0 ABC transporter Arch_ATPase PF01637.13 KOO32887.1 - 0.096 12.3 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase AAA_29 PF13555.1 KOO32887.1 - 0.12 11.9 0.0 0.72 9.4 0.0 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain Septin PF00735.13 KOO32887.1 - 0.16 10.9 0.0 25 3.7 0.0 2.8 3 1 1 4 4 4 0 Septin Miro PF08477.8 KOO32887.1 - 0.19 12.2 0.0 0.33 11.4 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein EF-hand_5 PF13202.1 KOO32889.1 - 5.7e-05 22.2 1.2 0.00014 21.0 0.8 1.6 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KOO32889.1 - 0.00042 19.4 0.6 0.001 18.2 0.4 1.7 1 0 0 1 1 1 1 EF hand TPR_9 PF13371.1 KOO32889.1 - 0.0075 16.0 0.3 0.017 14.9 0.2 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat EF-hand_7 PF13499.1 KOO32889.1 - 0.008 16.2 0.1 0.018 15.1 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO32889.1 - 0.0081 15.9 0.4 0.0081 15.9 0.3 1.9 2 0 0 2 2 2 1 EF-hand domain TPR_11 PF13414.1 KOO32889.1 - 0.014 14.9 1.0 0.03 13.9 0.7 1.5 1 0 0 1 1 1 0 TPR repeat TPR_1 PF00515.23 KOO32889.1 - 0.39 10.4 3.2 0.34 10.5 0.7 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO32889.1 - 0.86 9.6 3.5 0.95 9.5 1.4 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat RRM_1 PF00076.17 KOO32890.1 - 6.5e-07 28.9 0.0 9.8e-07 28.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO32890.1 - 1.6e-05 24.6 0.0 2.3e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO32890.1 - 2e-05 24.5 0.0 3.4e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 KOO32890.1 - 0.017 14.8 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF3584 PF12128.3 KOO32891.1 - 0.095 10.0 4.6 0.12 9.6 3.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ATP-synt_DE PF00401.15 KOO32891.1 - 0.36 10.7 9.4 0.091 12.6 4.3 1.7 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain PsbQ PF05757.6 KOO32891.1 - 2.1 7.7 10.5 12 5.2 4.7 2.1 2 0 0 2 2 2 0 Oxygen evolving enhancer protein 3 (PsbQ) cNMP_binding PF00027.24 KOO32892.1 - 1.8e-07 30.8 0.0 4.3e-07 29.6 0.0 1.7 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans PF00520.26 KOO32892.1 - 0.00025 20.3 0.0 0.0006 19.1 0.0 1.6 1 1 0 1 1 1 1 Ion transport protein Ion_trans_N PF08412.5 KOO32892.1 - 0.11 11.8 0.0 0.24 10.7 0.0 1.5 1 0 0 1 1 1 0 Ion transport protein N-terminal AAA_28 PF13521.1 KOO32893.1 - 1.9e-22 79.9 0.0 4.8e-22 78.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.5 KOO32893.1 - 0.065 12.4 0.4 0.23 10.6 0.0 2.0 2 0 0 2 2 2 0 Chromatin associated protein KTI12 GxGYxYP PF14323.1 KOO32894.1 - 7.5e-50 169.9 0.0 4.9e-25 88.1 0.0 2.1 1 1 1 2 2 2 2 GxGYxY sequence motif in domain of unknown function DUF2451 PF10474.4 KOO32896.1 - 1.4e-46 159.1 0.0 2.6e-46 158.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) DUF2450 PF10475.4 KOO32896.1 - 1.1e-37 129.5 0.0 1.7e-37 128.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function N-terminal domain (DUF2450) FlgN PF05130.7 KOO32896.1 - 1 9.5 11.3 2.2 8.5 0.2 3.7 4 0 0 4 4 4 0 FlgN protein DUF1138 PF06592.8 KOO32897.1 - 0.045 13.7 0.1 15 5.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1138) Methyltransf_21 PF05050.7 KOO32898.1 - 4e-15 56.1 0.0 9.7e-15 54.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_18 PF12847.2 KOO32898.1 - 0.00033 21.2 0.0 0.00063 20.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain SAM_MT PF04445.8 KOO32898.1 - 0.07 12.2 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase Toxin_38 PF14866.1 KOO32898.1 - 0.086 12.9 1.0 0.17 11.9 0.7 1.4 1 0 0 1 1 1 0 Potassium channel toxin PUA_2 PF14306.1 KOO32898.1 - 0.17 11.2 0.0 0.32 10.3 0.0 1.3 1 0 0 1 1 1 0 PUA-like domain LRR_6 PF13516.1 KOO32899.1 - 1.8e-43 141.6 55.5 0.028 14.4 0.1 27.9 29 0 0 29 29 29 10 Leucine Rich repeat LRR_4 PF12799.2 KOO32899.1 - 6e-17 60.8 38.3 0.098 12.3 0.1 15.7 13 3 2 16 16 16 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO32899.1 - 9.3e-16 55.4 21.1 4.9 7.5 0.2 18.7 23 1 0 23 23 22 1 Leucine Rich Repeat MFS_1 PF07690.11 KOO32899.1 - 7.3e-15 54.5 81.5 1.9e-06 26.8 6.2 3.6 2 1 1 3 3 3 3 Major Facilitator Superfamily LRR_8 PF13855.1 KOO32899.1 - 7.5e-09 35.2 23.0 5.3 6.8 0.0 14.6 15 1 1 16 16 16 2 Leucine rich repeat NACHT PF05729.7 KOO32899.1 - 1e-05 25.2 1.1 3.8e-05 23.4 0.0 2.1 2 0 0 2 2 2 1 NACHT domain LRR_7 PF13504.1 KOO32899.1 - 0.00024 20.7 44.0 23 5.7 0.3 17.3 22 0 0 22 22 19 0 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO32899.1 - 0.0015 18.6 0.1 91 3.3 0.0 6.7 6 0 0 6 6 6 0 RNA 2'-O ribose methyltransferase substrate binding DUF1874 PF08960.5 KOO32899.1 - 0.078 12.7 0.4 14 5.4 0.0 4.0 3 1 1 4 4 4 0 Domain of unknown function (DUF1874) HTH_40 PF14493.1 KOO32899.1 - 0.55 10.4 1.6 58 4.0 0.0 4.6 5 0 0 5 5 4 0 Helix-turn-helix domain MFS_1_like PF12832.2 KOO32899.1 - 0.57 10.0 2.8 15 5.4 0.0 3.3 3 0 0 3 3 3 0 MFS_1 like family FIBP PF05427.6 KOO32899.1 - 5.2 6.2 0.2 10 5.2 0.0 1.5 2 0 0 2 2 2 0 Acidic fibroblast growth factor binding (FIBP) Kinesin PF00225.18 KOO32902.1 - 3.4e-88 295.5 0.2 5.6e-46 156.7 0.0 2.6 2 0 0 2 2 2 2 Kinesin motor domain Mannosyl_trans3 PF11051.3 KOO32903.1 - 9.5e-07 28.4 0.0 1.4e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Glyco_transf_8 PF01501.15 KOO32903.1 - 9.7e-05 21.8 0.0 0.00013 21.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 HSV_VP16_C PF12149.3 KOO32903.1 - 0.099 12.3 0.3 42 3.9 0.0 3.2 3 0 0 3 3 3 0 Herpes simplex virus virion protein 16 C terminal NHL PF01436.16 KOO32904.1 - 8.8e-18 63.2 6.3 0.0044 16.9 0.0 6.4 6 0 0 6 6 6 6 NHL repeat SGL PF08450.7 KOO32904.1 - 2.5e-05 23.7 0.0 0.0064 15.8 0.0 2.9 2 2 0 2 2 2 2 SMP-30/Gluconolaconase/LRE-like region PQQ_3 PF13570.1 KOO32904.1 - 0.0019 18.3 0.9 2.7 8.4 0.0 3.4 4 0 0 4 4 4 2 PQQ-like domain Leader_Trp PF08255.6 KOO32906.1 - 0.079 12.6 0.4 0.26 11.0 0.3 1.9 1 0 0 1 1 1 0 Trp-operon Leader Peptide Cupin_8 PF13621.1 KOO32907.1 - 6.6e-32 110.9 0.0 1.4e-31 109.9 0.0 1.5 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 KOO32907.1 - 0.00076 18.8 4.5 0.0011 18.2 0.0 3.0 3 1 0 3 3 3 1 Cupin superfamily protein DUF3584 PF12128.3 KOO32907.1 - 5.6 4.1 33.6 8 3.6 23.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ubiquitin PF00240.18 KOO32908.1 - 0.00082 18.7 0.0 0.13 11.6 0.0 2.7 2 1 0 2 2 2 2 Ubiquitin family ART PF01129.13 KOO32909.1 - 8e-06 25.1 0.0 1.2e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.9 KOO32909.1 - 0.0013 18.0 0.0 1.2 8.3 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosyltransferase exoenzyme HALZ PF02183.13 KOO32910.1 - 0.029 14.0 0.7 0.07 12.8 0.5 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper V_ATPase_I PF01496.14 KOO32910.1 - 0.81 7.4 2.7 1.1 7.0 1.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family APG6 PF04111.7 KOO32910.1 - 8.7 5.2 13.0 13 4.7 9.0 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Aa_trans PF01490.13 KOO32912.1 - 2e-52 178.0 18.7 2.4e-52 177.8 12.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 KOO32912.1 - 1e-09 37.7 10.9 1e-09 37.7 7.5 2.7 3 1 0 3 3 3 1 Tryptophan/tyrosine permease family PAP2_C PF14360.1 KOO32912.1 - 3.9 7.8 11.2 4.4 7.6 0.2 4.0 4 1 1 5 5 5 0 PAP2 superfamily C-terminal GTP_EFTU PF00009.22 KOO32913.1 - 4.8e-37 127.2 0.0 9.3e-37 126.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 KOO32913.1 - 1.7e-23 82.5 1.5 5.5e-23 80.9 0.1 2.3 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 KOO32913.1 - 9.2e-15 54.5 1.2 7.2e-09 35.6 0.1 3.1 2 0 0 2 2 2 2 Elongation factor Tu domain 2 IF2_N PF04760.10 KOO32913.1 - 9.4e-12 44.4 0.1 2.9e-11 42.8 0.1 1.9 2 0 0 2 2 2 1 Translation initiation factor IF-2, N-terminal region Miro PF08477.8 KOO32913.1 - 2e-05 25.0 0.0 4.4e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 KOO32913.1 - 2e-05 24.4 0.0 4.1e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.17 KOO32913.1 - 0.0071 15.7 0.0 0.016 14.5 0.0 1.6 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 KOO32913.1 - 0.05 12.8 0.0 0.26 10.4 0.0 2.1 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Mito_carr PF00153.22 KOO32914.1 - 3.3e-48 161.3 3.9 3.4e-16 58.7 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Laminin_G_3 PF13385.1 KOO32915.1 - 0.00053 20.2 5.8 0.0012 19.0 4.1 1.8 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Velvet PF11754.3 KOO32915.1 - 0.13 11.8 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Velvet factor Dimer_Tnp_hAT PF05699.9 KOO32916.1 - 4.2e-06 26.2 0.1 8.6e-06 25.2 0.1 1.5 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region NUDIX PF00293.23 KOO32917.1 - 8.6e-28 96.6 0.1 1.2e-27 96.2 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Tup_N PF08581.5 KOO32919.1 - 0.12 12.6 1.6 0.29 11.3 0.2 2.3 2 0 0 2 2 2 0 Tup N-terminal HSP70 PF00012.15 KOO32920.1 - 0.0011 17.0 2.0 0.0012 16.8 1.4 1.0 1 0 0 1 1 1 1 Hsp70 protein Pec_lyase PF09492.5 KOO32920.1 - 0.11 11.6 0.1 0.13 11.4 0.1 1.1 1 0 0 1 1 1 0 Pectic acid lyase Sec1 PF00995.18 KOO32921.1 - 4e-80 270.0 0.0 1.5e-68 231.8 0.0 2.0 1 1 1 2 2 2 2 Sec1 family MobC PF05713.6 KOO32921.1 - 0.0014 18.5 0.5 0.012 15.6 0.1 2.6 2 0 0 2 2 2 1 Bacterial mobilisation protein (MobC) K-box PF01486.12 KOO32921.1 - 0.04 13.7 0.9 0.073 12.8 0.7 1.4 1 0 0 1 1 1 0 K-box region EF-hand_7 PF13499.1 KOO32922.1 - 7e-07 29.2 0.3 1.5e-06 28.1 0.2 1.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO32922.1 - 1.8e-05 24.2 0.0 0.00041 20.0 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.1 KOO32922.1 - 4e-05 22.7 0.1 7.7e-05 21.8 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KOO32922.1 - 0.00037 19.5 0.1 0.0011 18.1 0.0 1.8 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.1 KOO32922.1 - 0.0015 18.1 0.4 0.018 14.6 0.0 2.4 1 1 1 2 2 2 1 EF-hand domain pair EF_assoc_1 PF08355.7 KOO32922.1 - 0.0049 16.1 0.0 0.0086 15.3 0.0 1.3 1 0 0 1 1 1 1 EF hand associated DUF3037 PF11236.3 KOO32922.1 - 0.067 13.2 0.0 8.8 6.4 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3037) ANT PF03374.9 KOO32923.1 - 0.015 15.3 0.3 0.067 13.2 0.2 2.1 1 1 0 2 2 2 0 Phage antirepressor protein KilAC domain TIP39 PF14980.1 KOO32923.1 - 2.8 7.6 7.1 0.97 9.1 0.4 3.2 3 0 0 3 3 3 0 TIP39 peptide Tub PF01167.13 KOO32925.1 - 3.1e-87 291.6 0.0 4.5e-87 291.1 0.0 1.2 1 0 0 1 1 1 1 Tub family OTU PF02338.14 KOO32925.1 - 1.5e-11 44.8 0.1 4.2e-11 43.4 0.1 1.8 1 0 0 1 1 1 1 OTU-like cysteine protease Trypsin_2 PF13365.1 KOO32925.1 - 5.4e-05 23.1 0.0 0.00019 21.3 0.0 2.1 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_C65 PF10275.4 KOO32925.1 - 0.093 12.0 1.4 0.34 10.2 0.9 1.9 1 1 0 1 1 1 0 Peptidase C65 Otubain DUF3824 PF12868.2 KOO32925.1 - 0.88 10.5 15.1 0.072 14.0 6.3 2.2 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) Flagellin_N PF00669.15 KOO32926.1 - 0.03 14.1 0.1 0.074 12.8 0.0 1.6 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region Tegument_dsDNA PF12818.2 KOO32927.1 - 0.013 14.4 0.0 0.015 14.2 0.0 1.1 1 0 0 1 1 1 0 dsDNA viral tegument protein FAD_binding_4 PF01565.18 KOO32928.1 - 0.058 12.8 0.1 0.11 11.9 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain ADK PF00406.17 KOO32929.1 - 4.4e-30 104.5 0.0 3.2e-20 72.5 0.0 2.1 2 0 0 2 2 2 2 Adenylate kinase ADK_lid PF05191.9 KOO32929.1 - 0.00012 21.6 0.1 0.37 10.4 0.0 2.5 2 0 0 2 2 2 2 Adenylate kinase, active site lid AAA_17 PF13207.1 KOO32929.1 - 0.018 15.8 0.0 0.096 13.5 0.0 2.1 2 1 0 2 2 2 0 AAA domain Cytidylate_kin2 PF13189.1 KOO32929.1 - 0.15 11.9 0.0 7 6.5 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase-like family 2OG-FeII_Oxy PF03171.15 KOO32930.1 - 2.4e-07 30.9 0.0 4.6e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.1 KOO32930.1 - 1e-06 29.1 0.1 1.9e-06 28.2 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ShK PF01549.19 KOO32930.1 - 0.00011 22.4 11.1 0.00011 22.4 7.7 2.4 2 0 0 2 2 2 1 ShK domain-like 2OG-FeII_Oxy_4 PF13661.1 KOO32930.1 - 0.00024 20.6 0.1 0.00065 19.2 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Chorismate_bind PF00425.13 KOO32931.1 - 1.6e-81 273.4 0.0 2.1e-81 273.0 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme Aminotran_4 PF01063.14 KOO32931.1 - 2e-19 70.0 0.0 3.4e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class IV TrbM PF07424.6 KOO32931.1 - 0.06 13.3 0.0 11 6.0 0.0 2.3 2 0 0 2 2 2 0 TrbM CLP_protease PF00574.18 KOO32932.1 - 4.1e-45 153.6 0.2 8.5e-45 152.6 0.2 1.5 1 1 0 1 1 1 1 Clp protease ECH PF00378.15 KOO32932.1 - 0.029 13.4 0.1 0.043 12.9 0.0 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase family Peptidase_S49 PF01343.13 KOO32932.1 - 0.041 13.6 0.3 0.064 13.0 0.2 1.3 1 0 0 1 1 1 0 Peptidase family S49 DUF3311 PF11755.3 KOO32932.1 - 0.068 12.7 0.3 0.19 11.3 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3311) Fer2 PF00111.22 KOO32933.1 - 4.1e-06 26.4 1.8 7.3e-06 25.6 1.2 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain EF-hand_6 PF13405.1 KOO32934.1 - 3.4e-08 32.6 0.4 0.00036 20.1 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.27 KOO32934.1 - 1.9e-06 26.7 0.1 0.006 15.8 0.0 3.1 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 KOO32934.1 - 9.3e-06 25.6 0.8 0.011 15.8 0.1 3.2 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO32934.1 - 0.0095 15.2 0.2 0.25 10.7 0.0 2.9 3 0 0 3 3 3 1 EF hand UTP15_C PF09384.5 KOO32934.1 - 0.012 15.3 0.1 0.025 14.2 0.1 1.5 1 0 0 1 1 1 0 UTP15 C terminal Ank_2 PF12796.2 KOO32935.1 - 7.1e-12 45.4 4.5 2.9e-09 37.1 0.5 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO32935.1 - 5.4e-08 33.1 0.8 0.0061 17.0 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO32935.1 - 0.0011 18.6 7.1 0.21 11.4 0.2 3.6 3 1 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 KOO32935.1 - 0.12 12.6 1.0 16 6.0 0.0 3.5 3 0 0 3 3 3 0 Ankyrin repeat Ank_5 PF13857.1 KOO32935.1 - 0.43 10.8 3.7 18 5.7 0.1 3.4 1 1 2 3 3 3 0 Ankyrin repeats (many copies) STE3 PF02076.10 KOO32936.1 - 0.37 9.8 0.1 0.59 9.1 0.0 1.2 1 0 0 1 1 1 0 Pheromone A receptor CAF-1_p150 PF11600.3 KOO32936.1 - 1.2 8.4 29.2 1.8 7.8 20.3 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal RNase_H2-Ydr279 PF09468.5 KOO32936.1 - 1.6 7.8 4.6 2.6 7.1 3.2 1.2 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Borrelia_P83 PF05262.6 KOO32936.1 - 8 4.6 18.8 11 4.0 13.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein WD40 PF00400.27 KOO32937.1 - 4.2e-30 102.5 14.5 4.4e-06 26.3 0.0 7.6 7 1 0 7 7 7 6 WD domain, G-beta repeat LRR_4 PF12799.2 KOO32937.1 - 0.008 15.7 0.1 19 5.0 0.0 3.5 2 1 2 4 4 4 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO32937.1 - 0.012 15.5 0.5 38 4.8 0.2 4.3 3 1 0 3 3 3 0 Leucine Rich Repeat BBS2_Mid PF14783.1 KOO32937.1 - 0.022 14.5 0.0 2.2 8.0 0.0 2.4 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Kelch_6 PF13964.1 KOO32937.1 - 0.068 13.3 0.1 6.7 7.0 0.0 3.4 3 0 0 3 3 3 0 Kelch motif LRR_6 PF13516.1 KOO32937.1 - 0.19 11.9 0.7 56 4.2 0.1 4.1 4 0 0 4 4 4 0 Leucine Rich repeat LRR_8 PF13855.1 KOO32937.1 - 0.21 11.3 0.9 50 3.7 0.0 3.4 3 0 0 3 3 3 0 Leucine rich repeat LRR_7 PF13504.1 KOO32937.1 - 0.45 10.9 6.8 43 4.9 0.0 5.1 5 0 0 5 5 5 0 Leucine rich repeat IQ PF00612.22 KOO32939.1 - 0.19 11.4 9.6 0.02 14.5 2.3 2.7 2 0 0 2 2 2 0 IQ calmodulin-binding motif LRR_6 PF13516.1 KOO32940.1 - 1.8e-10 39.7 1.4 0.066 13.3 0.1 4.7 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.2 KOO32940.1 - 0.00073 19.1 0.0 0.0084 15.7 0.0 2.3 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) DUF3197 PF11432.3 KOO32940.1 - 0.06 13.3 0.1 0.15 12.0 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3197) LRR_1 PF00560.28 KOO32940.1 - 0.12 12.5 0.2 6.3 7.2 0.1 3.6 2 1 1 3 3 3 0 Leucine Rich Repeat Glyco_transf_92 PF01697.22 KOO32941.1 - 0.044 13.0 0.0 0.05 12.8 0.0 1.0 1 0 0 1 1 1 0 Glycosyltransferase family 92 Pkinase PF00069.20 KOO32942.1 - 2.5e-61 207.1 0.0 3.1e-61 206.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO32942.1 - 7.2e-46 156.3 0.0 9.4e-46 155.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Chloroa_b-bind PF00504.16 KOO32942.1 - 2.1e-34 119.0 0.1 5e-34 117.8 0.0 1.7 2 0 0 2 2 2 1 Chlorophyll A-B binding protein Kinase-like PF14531.1 KOO32942.1 - 1.4e-08 34.0 0.0 1.1e-06 27.8 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 KOO32942.1 - 1.5e-05 24.8 0.3 0.013 15.2 0.1 2.9 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.9 KOO32942.1 - 0.076 12.0 0.1 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 KOO32942.1 - 0.14 10.9 0.0 0.22 10.3 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 RIO1 PF01163.17 KOO32942.1 - 0.16 11.3 0.1 0.33 10.2 0.0 1.5 1 0 0 1 1 1 0 RIO1 family COQ9 PF08511.6 KOO32943.1 - 8.6e-09 34.7 0.0 1.6e-08 33.9 0.0 1.5 1 1 0 1 1 1 1 COQ9 Peptidase_M16_C PF05193.16 KOO32944.1 - 4.2e-25 88.4 0.0 5.6e-12 45.7 0.0 3.1 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 KOO32944.1 - 2.5e-13 50.0 0.0 7.7e-13 48.4 0.0 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Ribosomal_L13e PF01294.13 KOO32945.1 - 1.8e-05 24.2 4.3 0.33 10.3 0.2 3.9 1 1 2 3 3 3 3 Ribosomal protein L13e RPAP1_C PF08620.5 KOO32945.1 - 1.5 8.6 5.0 43 4.0 0.0 4.0 4 2 2 6 6 6 0 RPAP1-like, C-terminal Peptidase_M17 PF00883.16 KOO32946.1 - 8.3e-106 353.3 0.1 1.2e-105 352.7 0.1 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain DUF4419 PF14388.1 KOO32946.1 - 1.3e-19 70.5 0.0 1.9e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) Peptidase_M17_N PF02789.12 KOO32946.1 - 5.2e-19 68.2 1.4 5e-18 65.0 0.5 2.5 2 0 0 2 2 2 1 Cytosol aminopeptidase family, N-terminal domain RrnaAD PF00398.15 KOO32948.1 - 1.5e-25 89.7 0.0 1.8e-25 89.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Ammonium_transp PF00909.16 KOO32950.1 - 2e-117 392.0 29.8 2.3e-117 391.8 20.7 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF1691 PF07950.6 KOO32950.1 - 6.2 6.7 7.5 1.3 9.0 0.1 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF1691) p25-alpha PF05517.7 KOO32951.1 - 0.055 13.7 0.3 0.65 10.2 0.1 2.1 1 1 0 2 2 2 0 p25-alpha DEAD PF00270.24 KOO32954.1 - 1.1e-31 109.6 0.0 1.1e-18 67.2 0.0 3.2 1 1 2 3 3 3 3 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO32954.1 - 4.6e-24 84.0 0.0 6.9e-23 80.3 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Ycf1 PF05758.7 KOO32954.1 - 0.23 9.1 0.1 0.23 9.1 0.0 1.1 1 0 0 1 1 1 0 Ycf1 CMS1 PF14617.1 KOO32954.1 - 0.92 8.5 0.0 0.92 8.5 0.0 3.3 2 2 1 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit Abhydrolase_9 PF10081.4 KOO32955.1 - 0.046 12.4 0.0 0.08 11.6 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta-hydrolase family Mito_carr PF00153.22 KOO32956.1 - 5e-61 202.4 0.8 1.7e-25 88.5 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein PK PF00224.16 KOO32957.1 - 7e-115 383.3 1.0 8.8e-115 383.0 0.7 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.11 KOO32957.1 - 8.3e-12 44.6 0.0 3.4e-11 42.7 0.0 2.0 1 1 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.9 KOO32957.1 - 0.017 13.9 0.1 0.043 12.6 0.1 1.7 1 0 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family URO-D PF01208.12 KOO32958.1 - 2.6e-99 332.4 0.0 3e-99 332.1 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) IF2_N PF04760.10 KOO32958.1 - 0.05 13.2 0.0 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region E1-E2_ATPase PF00122.15 KOO32959.1 - 4.6e-46 156.7 2.9 6.9e-46 156.1 2.0 1.3 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_N PF00690.21 KOO32959.1 - 4.7e-05 22.7 0.0 0.00011 21.5 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.21 KOO32959.1 - 0.00028 21.3 0.0 0.00051 20.5 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOO32959.1 - 0.00038 20.3 0.0 0.00094 19.0 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Endosulfine PF04667.12 KOO32960.1 - 1.6e-08 34.3 0.0 2e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region NDK PF00334.14 KOO32961.1 - 0.004 16.9 0.0 0.0097 15.7 0.0 1.6 2 0 0 2 2 2 1 Nucleoside diphosphate kinase Calreticulin PF00262.13 KOO32962.1 - 1.6e-141 471.2 2.5 1.9e-141 471.0 1.7 1.1 1 0 0 1 1 1 1 Calreticulin family TPR_11 PF13414.1 KOO32963.1 - 3.4e-11 42.6 12.9 0.0014 18.2 0.2 4.5 4 0 0 4 4 4 3 TPR repeat TPR_16 PF13432.1 KOO32963.1 - 5e-09 36.5 17.9 0.0021 18.7 0.7 5.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOO32963.1 - 1.5e-08 34.5 25.5 0.0054 17.2 0.4 8.0 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.1 KOO32963.1 - 8.9e-07 29.1 22.9 0.00023 21.4 1.3 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO32963.1 - 6.3e-06 25.7 13.4 0.6 10.1 0.0 6.0 5 0 0 5 5 5 2 Tetratricopeptide repeat Apc3 PF12895.2 KOO32963.1 - 6.6e-06 26.1 6.5 0.1 12.7 0.0 4.3 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.1 KOO32963.1 - 3.6e-05 22.9 8.6 0.049 12.6 0.1 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO32963.1 - 3.8e-05 23.1 3.1 1.3 9.0 0.1 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_20 PF14561.1 KOO32963.1 - 0.00017 21.6 15.4 0.0052 16.8 0.2 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO32963.1 - 0.00083 19.3 3.2 0.069 13.3 0.2 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.1 KOO32963.1 - 0.0039 17.5 5.9 2.3 8.8 0.2 4.8 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO32963.1 - 0.029 14.1 3.4 6.7 6.7 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Nic96 PF04097.9 KOO32963.1 - 0.22 9.5 0.1 0.34 8.9 0.1 1.3 1 0 0 1 1 1 0 Nup93/Nic96 TPR_12 PF13424.1 KOO32963.1 - 0.42 10.5 14.1 2.3 8.2 0.7 4.5 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.9 KOO32963.1 - 0.78 10.3 8.5 6 7.6 0.1 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOO32963.1 - 0.91 9.2 6.7 22 4.8 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat DLH PF01738.13 KOO32964.1 - 1.8e-19 69.8 0.0 2e-19 69.7 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 KOO32964.1 - 7.5e-08 32.2 0.0 1.3e-07 31.5 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 KOO32964.1 - 3.7e-05 23.0 0.0 0.15 11.2 0.0 2.1 1 1 1 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_6 PF12697.2 KOO32964.1 - 0.00025 20.9 1.5 0.33 10.7 0.1 2.2 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 KOO32964.1 - 0.0019 17.6 0.0 0.0024 17.3 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase DUF1100 PF06500.6 KOO32964.1 - 0.003 16.1 0.0 0.0043 15.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Abhydrolase_1 PF00561.15 KOO32964.1 - 0.0069 15.9 0.0 0.0089 15.5 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold BAAT_C PF08840.6 KOO32964.1 - 0.068 12.8 0.4 2.5 7.7 0.0 2.2 2 1 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Kinesin PF00225.18 KOO32965.1 - 5.1e-34 117.4 0.0 5.4e-33 114.1 0.0 2.4 2 1 0 2 2 2 1 Kinesin motor domain His_Phos_1 PF00300.17 KOO32965.1 - 6.9e-15 55.4 0.0 1.4e-14 54.4 0.0 1.5 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) IstB_IS21 PF01695.12 KOO32965.1 - 0.021 14.2 0.0 0.039 13.3 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_22 PF13401.1 KOO32965.1 - 0.12 12.4 0.0 0.58 10.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain EMP70 PF02990.11 KOO32966.1 - 5.8e-173 576.0 4.9 7.1e-173 575.7 3.4 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 SMC_Nse1 PF07574.8 KOO32967.1 - 0.00013 21.6 0.1 0.039 13.5 0.0 2.1 1 1 1 2 2 2 2 Nse1 non-SMC component of SMC5-6 complex DUF2270 PF10028.4 KOO32967.1 - 0.11 11.9 0.0 0.14 11.6 0.0 1.1 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2270) Asp_Arg_Hydrox PF05118.10 KOO32969.1 - 1.2e-27 96.7 0.0 2e-27 96.0 0.0 1.3 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase Cupin_2 PF07883.6 KOO32969.1 - 0.054 12.9 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Cupin domain Chloroa_b-bind PF00504.16 KOO32970.1 - 1.4e-31 109.8 0.0 1.9e-31 109.4 0.0 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Sel1 PF08238.7 KOO32971.1 - 3.1e-72 237.4 62.1 2.3e-08 34.3 0.4 10.4 11 0 0 11 11 11 9 Sel1 repeat Dehyd-heme_bind PF09098.5 KOO32971.1 - 0.071 12.5 4.3 2.2 7.7 0.0 3.7 1 1 2 4 4 4 0 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding NodS PF05401.6 KOO32971.1 - 4.5 6.6 10.2 18 4.6 0.1 4.7 5 1 1 6 6 6 0 Nodulation protein S (NodS) Arm PF00514.18 KOO32973.1 - 4.1e-30 102.5 31.6 3.4e-06 26.6 0.0 7.1 7 0 0 7 7 7 7 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO32973.1 - 0.0015 18.7 45.8 0.49 10.6 5.0 4.3 1 1 4 5 5 5 4 HEAT repeats CobA_CobO_BtuR PF02572.10 KOO32973.1 - 0.0075 15.9 4.8 24 4.4 0.0 5.6 7 0 0 7 7 7 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Arm_2 PF04826.8 KOO32973.1 - 0.014 14.5 0.0 4.1 6.4 0.0 3.5 3 1 2 5 5 5 0 Armadillo-like DUF3518 PF12031.3 KOO32973.1 - 1.2 7.8 11.7 5.9 5.6 0.1 4.4 1 1 3 5 5 5 0 Domain of unknown function (DUF3518) Succ_CoA_lig PF13607.1 KOO32973.1 - 9 5.9 26.7 0.1 12.1 1.4 4.0 2 2 3 5 5 5 0 Succinyl-CoA ligase like flavodoxin domain HEAT PF02985.17 KOO32973.1 - 10 6.5 16.6 45 4.5 0.0 6.0 6 2 1 7 7 7 0 HEAT repeat Arm PF00514.18 KOO32974.1 - 1.8e-40 135.4 40.1 4.7e-06 26.2 0.0 9.1 9 0 0 9 9 9 9 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 KOO32974.1 - 0.0018 17.4 0.0 6 5.8 0.0 4.7 3 2 1 5 5 5 1 Armadillo-like HEAT_2 PF13646.1 KOO32974.1 - 0.0077 16.4 61.7 0.46 10.7 4.5 5.6 1 1 5 7 7 7 7 HEAT repeats Rb_C PF08934.5 KOO32974.1 - 0.12 12.0 0.0 25 4.4 0.0 3.9 2 2 4 6 6 6 0 Rb C-terminal domain PEP-utilisers_N PF05524.8 KOO32975.1 - 0.058 13.1 4.6 0.074 12.8 3.2 1.3 1 1 0 1 1 1 0 PEP-utilising enzyme, N-terminal DUF883 PF05957.8 KOO32975.1 - 0.1 12.9 1.8 0.14 12.5 1.2 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) DUF3654 PF12376.3 KOO32975.1 - 0.15 11.8 0.8 0.22 11.3 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3654) HisKA_3 PF07730.8 KOO32975.1 - 0.16 12.2 5.0 0.85 10.0 3.2 2.1 1 1 1 2 2 2 0 Histidine kinase DUF1470 PF07336.6 KOO32975.1 - 2.9 8.2 9.4 2.8 8.2 3.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1470) WASH-7_C PF14746.1 KOO32976.1 - 6.6e-50 169.0 0.2 7.3e-50 168.8 0.1 1.0 1 0 0 1 1 1 1 WASH complex subunit 7, C-terminal Linocin_M18 PF04454.7 KOO32976.1 - 0.029 13.2 0.1 0.037 12.9 0.1 1.1 1 0 0 1 1 1 0 Encapsulating protein for peroxidase PolyA_pol_arg_C PF12626.2 KOO32976.1 - 0.066 12.8 0.5 0.089 12.4 0.4 1.2 1 0 0 1 1 1 0 Polymerase A arginine-rich C-terminus Mitofilin PF09731.4 KOO32977.1 - 8.6e-33 113.8 23.6 1.1e-32 113.5 16.3 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein Glyco_hydro_1 PF00232.13 KOO32978.1 - 2.1e-139 464.6 0.1 2.5e-139 464.3 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 ArfGap PF01412.13 KOO32979.1 - 3.3e-30 104.2 1.5 4e-30 103.9 1.0 1.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Thioredoxin_2 PF13098.1 KOO32979.1 - 0.016 15.3 0.0 0.027 14.6 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain GRDA PF04723.9 KOO32979.1 - 0.11 12.1 0.1 0.17 11.6 0.1 1.3 1 0 0 1 1 1 0 Glycine reductase complex selenoprotein A DnaJ_CXXCXGXG PF00684.14 KOO32979.1 - 0.16 12.0 3.9 0.45 10.6 2.6 1.8 1 1 0 1 1 1 0 DnaJ central domain ACBP PF00887.14 KOO32980.1 - 2e-16 59.4 0.0 3.9e-16 58.5 0.0 1.4 1 0 0 1 1 1 1 Acyl CoA binding protein polyprenyl_synt PF00348.12 KOO32982.1 - 0.0015 17.4 0.0 0.0019 17.0 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase HCR PF07111.7 KOO32982.1 - 0.026 12.5 0.0 0.026 12.5 0.0 1.1 1 0 0 1 1 1 0 Alpha helical coiled-coil rod protein (HCR) RVT_2 PF07727.9 KOO32983.1 - 1.7e-29 102.5 0.0 5.7e-28 97.5 0.0 2.4 3 0 0 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.1 KOO32983.1 - 0.0018 17.8 0.6 0.0046 16.5 0.1 1.8 2 0 0 2 2 2 1 GAG-pre-integrase domain LRR_6 PF13516.1 KOO32984.1 - 2.9e-24 82.3 1.4 0.00028 20.6 0.0 6.5 6 0 0 6 6 6 5 Leucine Rich repeat CbiG_N PF11760.3 KOO32984.1 - 0.0019 17.8 5.2 4.7 6.9 0.1 4.2 3 1 1 4 4 4 2 Cobalamin synthesis G N-terminal LRR_4 PF12799.2 KOO32984.1 - 0.055 13.0 3.1 5.9 6.6 0.0 4.2 2 1 2 4 4 4 0 Leucine Rich repeats (2 copies) Phage_integ_N PF09003.5 KOO32984.1 - 0.33 10.6 8.4 12 5.6 0.1 4.0 1 1 3 4 4 4 0 Bacteriophage lambda integrase, N-terminal domain Peptidase_C48 PF02902.14 KOO32985.1 - 6.2e-11 42.3 0.0 3.4e-10 39.9 0.0 1.9 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain ACC_epsilon PF13822.1 KOO32985.1 - 0.083 13.2 0.7 0.24 11.7 0.1 1.9 2 0 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit DUF2113 PF09886.4 KOO32985.1 - 0.17 11.0 0.0 0.29 10.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2113) Gelsolin PF00626.17 KOO32986.1 - 2e-25 88.2 0.0 1.2e-07 31.3 0.0 3.3 3 0 0 3 3 3 3 Gelsolin repeat DNA_pol_B_exo1 PF03104.14 KOO32988.1 - 1.6e-40 139.0 0.0 2.7e-40 138.2 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.16 KOO32988.1 - 1.4e-21 76.8 0.0 3.5e-19 68.9 0.0 2.6 2 1 0 2 2 2 2 DNA polymerase family B RNase_H_2 PF13482.1 KOO32988.1 - 5.8e-07 29.4 0.0 3.5e-06 26.9 0.0 2.1 2 0 0 2 2 2 1 RNase_H superfamily DNA_pol_B_exo2 PF10108.4 KOO32988.1 - 6e-06 25.9 0.0 1.7e-05 24.5 0.0 1.6 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB WD40 PF00400.27 KOO32989.1 - 4.8e-34 115.0 3.8 2.3e-11 43.0 0.0 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat Prp19 PF08606.6 KOO32989.1 - 4e-14 52.0 0.8 7.7e-14 51.1 0.6 1.5 1 0 0 1 1 1 1 Prp19/Pso4-like DUF3987 PF13148.1 KOO32990.1 - 0.0054 15.3 0.1 1.6 7.2 0.0 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF3987) YqaJ PF09588.5 KOO32991.1 - 8.9e-28 97.1 0.0 1.2e-27 96.7 0.0 1.2 1 0 0 1 1 1 1 YqaJ-like viral recombinase domain BAH PF01426.13 KOO32992.1 - 4.7e-08 32.7 0.0 7.1e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 BAH domain Laminin_G_3 PF13385.1 KOO32993.1 - 1.1e-05 25.7 0.1 2.1e-05 24.8 0.1 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Rdx PF10262.4 KOO32994.1 - 2.3e-05 24.3 0.0 2.4e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Rdx family zf-C3HC4_3 PF13920.1 KOO32995.1 - 2.8e-12 46.1 10.5 5.3e-12 45.2 7.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO32995.1 - 2.4e-05 24.2 11.6 4.4e-05 23.4 8.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO32995.1 - 0.0031 17.3 13.0 0.0067 16.2 9.0 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 KOO32995.1 - 0.026 14.2 11.8 0.024 14.3 7.2 1.7 2 0 0 2 2 2 0 zinc-RING finger domain zf-P11 PF03854.9 KOO32995.1 - 0.077 12.4 5.7 0.2 11.1 4.0 1.7 1 0 0 1 1 1 0 P-11 zinc finger HATPase_c_3 PF13589.1 KOO32995.1 - 0.082 12.5 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Prok-RING_4 PF14447.1 KOO32995.1 - 0.48 10.0 5.5 1.1 8.9 3.8 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-H2C2_2 PF13465.1 KOO32997.1 - 8.2e-39 130.0 58.6 2.7e-07 30.5 0.7 9.3 9 0 0 9 9 9 7 Zinc-finger double domain zf-C2H2 PF00096.21 KOO32997.1 - 3.8e-35 118.1 63.6 8.3e-05 22.7 4.5 8.4 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOO32997.1 - 2.7e-25 86.8 50.9 0.0011 19.1 0.3 8.5 8 0 0 8 8 8 7 C2H2-type zinc finger zf-C2H2_6 PF13912.1 KOO32997.1 - 9.3e-10 38.0 35.8 0.01 15.7 0.3 8.2 8 0 0 8 8 8 6 C2H2-type zinc finger zf-RING_2 PF13639.1 KOO32997.1 - 0.0036 17.1 0.5 0.0036 17.1 0.4 4.1 4 3 2 6 6 6 1 Ring finger domain CHORD PF04968.7 KOO32997.1 - 0.36 11.1 44.8 2.5 8.3 0.6 7.3 1 1 6 7 7 7 0 CHORD Zn-ribbon_8 PF09723.5 KOO32997.1 - 1.1 9.2 31.3 5.4 7.0 0.1 8.1 8 0 0 8 8 8 0 Zinc ribbon domain Radical_SAM PF04055.16 KOO32999.1 - 4.7e-10 39.8 0.0 5.1e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 Radical SAM superfamily Flavodoxin_1 PF00258.20 KOO33000.1 - 4.7e-22 78.5 0.0 5.9e-22 78.2 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_NdrI PF07972.6 KOO33000.1 - 0.00096 19.0 0.0 0.0014 18.5 0.0 1.2 1 0 0 1 1 1 1 NrdI Flavodoxin like Flavodoxin_5 PF12724.2 KOO33000.1 - 0.09 12.7 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Flavodoxin domain DUF2999 PF11212.3 KOO33001.1 - 0.006 16.6 7.4 0.0095 15.9 0.1 3.0 3 1 1 4 4 4 1 Protein of unknown function (DUF2999) L27 PF02828.11 KOO33001.1 - 0.024 14.3 0.3 0.78 9.4 0.1 2.6 2 0 0 2 2 2 0 L27 domain Nuc_deoxyrib_tr PF05014.10 KOO33001.1 - 0.098 12.5 1.1 0.19 11.6 0.7 1.7 1 1 0 1 1 1 0 Nucleoside 2-deoxyribosyltransferase DUF3417 PF11897.3 KOO33001.1 - 0.11 12.3 5.0 16 5.4 0.2 3.5 2 2 2 4 4 4 0 Protein of unknown function (DUF3417) Rotamase PF00639.16 KOO33001.1 - 6 7.6 5.7 3.4 8.4 0.2 2.8 1 1 2 3 3 3 0 PPIC-type PPIASE domain DUF1641 PF07849.6 KOO33001.1 - 9.1 5.9 8.1 24 4.6 0.0 4.2 5 0 0 5 5 5 0 Protein of unknown function (DUF1641) SET PF00856.23 KOO33002.1 - 3.2e-07 30.8 0.0 1.8e-06 28.3 0.0 2.0 2 1 0 2 2 2 1 SET domain Ocnus PF05005.10 KOO33002.1 - 0.029 14.2 0.3 0.068 13.0 0.2 1.5 1 0 0 1 1 1 0 Janus/Ocnus family (Ocnus) HATPase_c_2 PF13581.1 KOO33004.1 - 4.7 7.0 9.4 0.23 11.2 0.1 2.9 2 1 0 2 2 2 0 Histidine kinase-like ATPase domain Elong-fact-P_C PF09285.6 KOO33005.1 - 0.00081 18.6 0.1 1e+02 2.3 0.0 4.8 5 0 0 5 5 5 5 Elongation factor P, C-terminal Aldo_ket_red PF00248.16 KOO33006.1 - 8.3e-47 159.3 0.0 8.8e-45 152.7 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family RHH_1 PF01402.16 KOO33006.1 - 0.1 12.5 0.1 2.3 8.2 0.0 2.4 2 0 0 2 2 2 0 Ribbon-helix-helix protein, copG family ACC_epsilon PF13822.1 KOO33008.1 - 0.52 10.7 2.5 1.4 9.2 1.3 2.1 2 0 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit F420_oxidored PF03807.12 KOO33009.1 - 1.7e-07 31.5 0.1 1.1e-06 28.9 0.0 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.18 KOO33009.1 - 0.0047 16.6 0.4 0.023 14.4 0.1 2.0 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Allexi_40kDa PF05549.6 KOO33009.1 - 0.066 12.4 0.0 0.088 12.0 0.0 1.3 1 0 0 1 1 1 0 Allexivirus 40kDa protein TRAM_LAG1_CLN8 PF03798.11 KOO33010.1 - 1.4e-16 60.6 11.1 1.9e-16 60.1 7.7 1.1 1 0 0 1 1 1 1 TLC domain LRR_6 PF13516.1 KOO33011.1 - 1.1e-21 74.3 11.4 0.0024 17.7 0.0 8.9 9 0 0 9 9 9 7 Leucine Rich repeat LRR_1 PF00560.28 KOO33011.1 - 6.7e-10 37.6 4.0 2 8.7 0.0 8.6 9 1 0 9 9 9 2 Leucine Rich Repeat LRR_4 PF12799.2 KOO33011.1 - 1.1e-07 31.3 7.3 0.1 12.2 0.3 6.1 4 2 5 9 9 9 5 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO33011.1 - 2.7e-07 29.6 9.5 2.4 8.7 0.3 8.4 10 0 0 10 10 10 2 Leucine rich repeat LRR_8 PF13855.1 KOO33011.1 - 0.0065 16.2 12.5 12 5.7 0.2 6.7 4 3 2 6 6 6 1 Leucine rich repeat LRR_3 PF07725.7 KOO33011.1 - 0.098 12.4 0.6 21 5.1 0.0 3.5 3 0 0 3 3 3 0 Leucine Rich Repeat 60KD_IMP PF02096.15 KOO33013.1 - 3.3e-44 150.9 0.0 4.1e-44 150.6 0.0 1.1 1 0 0 1 1 1 1 60Kd inner membrane protein DUF2910 PF11139.3 KOO33013.1 - 0.0045 16.1 0.1 0.0045 16.1 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2910) Pox_A_type_inc PF04508.7 KOO33014.1 - 0.022 14.5 6.7 2.8 7.9 0.3 5.6 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat TRAM_LAG1_CLN8 PF03798.11 KOO33015.1 - 9e-10 38.4 10.1 1.2e-09 38.0 7.0 1.4 1 1 0 1 1 1 1 TLC domain TPR_11 PF13414.1 KOO33016.1 - 2.2e-25 88.0 27.1 4.3e-07 29.4 0.0 6.4 6 0 0 6 6 6 5 TPR repeat TPR_2 PF07719.12 KOO33016.1 - 2e-08 33.4 26.6 3.9e-06 26.3 0.5 7.9 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO33016.1 - 1e-07 31.2 21.9 6.1e-05 22.4 0.2 7.6 8 0 0 8 8 8 1 Tetratricopeptide repeat CS PF04969.11 KOO33016.1 - 3.1e-05 24.4 0.0 5.3e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 CS domain SHNi-TPR PF10516.4 KOO33016.1 - 0.00018 20.7 1.7 0.024 13.8 0.0 3.1 3 0 0 3 3 3 1 SHNi-TPR TPR_8 PF13181.1 KOO33016.1 - 0.00074 19.1 3.0 0.25 11.2 0.1 4.7 6 0 0 6 6 6 1 Tetratricopeptide repeat BTAD PF03704.12 KOO33016.1 - 0.0058 16.9 3.9 0.0058 16.9 2.7 7.0 3 2 3 6 6 6 2 Bacterial transcriptional activator domain TPR_9 PF13371.1 KOO33016.1 - 0.097 12.5 26.5 0.056 13.3 1.0 6.3 5 2 2 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO33016.1 - 1.7 8.6 11.4 0.71 9.8 0.4 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO33016.1 - 1.9 9.1 7.1 24 5.6 0.4 5.5 6 1 1 7 7 7 0 Tetratricopeptide repeat PilJ PF13675.1 KOO33017.1 - 0.042 14.1 0.6 0.079 13.2 0.4 1.5 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term WD40 PF00400.27 KOO33018.1 - 7.5e-38 127.0 15.9 0.00019 21.2 0.0 10.4 11 0 0 11 11 11 7 WD domain, G-beta repeat EF-hand_1 PF00036.27 KOO33018.1 - 0.0012 17.9 0.7 0.0096 15.1 0.0 2.7 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.1 KOO33018.1 - 0.0025 17.1 0.1 0.077 12.3 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO33018.1 - 0.006 16.3 0.0 0.072 13.0 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.1 KOO33018.1 - 0.018 15.1 0.0 0.048 13.7 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair Beta_helix PF13229.1 KOO33019.1 - 0.0013 18.4 6.8 0.0013 18.4 4.7 2.7 1 1 0 2 2 2 1 Right handed beta helix region TBCC PF07986.7 KOO33020.1 - 4e-23 81.1 1.9 5e-23 80.7 1.3 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.6 KOO33020.1 - 0.0041 16.4 6.8 0.0068 15.7 4.7 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal ATP-synt_ab PF00006.20 KOO33021.1 - 2.1e-61 207.1 0.0 3e-61 206.6 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.18 KOO33021.1 - 4.7e-23 81.1 3.3 9.1e-23 80.2 2.3 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain KaiC PF06745.8 KOO33021.1 - 0.0032 16.6 0.1 0.0047 16.0 0.1 1.3 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.1 KOO33021.1 - 0.042 13.2 0.1 0.076 12.4 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 KOO33021.1 - 0.08 12.6 0.4 0.32 10.7 0.1 2.1 2 0 0 2 2 2 0 Part of AAA domain RecA PF00154.16 KOO33021.1 - 0.091 11.8 0.2 0.18 10.8 0.1 1.4 1 0 0 1 1 1 0 recA bacterial DNA recombination protein AAA_16 PF13191.1 KOO33021.1 - 0.11 12.4 0.1 0.27 11.1 0.0 1.7 2 1 0 2 2 2 0 AAA ATPase domain DUF2075 PF09848.4 KOO33021.1 - 0.17 10.7 0.0 0.39 9.6 0.1 1.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) NB-ARC PF00931.17 KOO33021.1 - 0.22 10.3 0.2 0.32 9.8 0.1 1.2 1 0 0 1 1 1 0 NB-ARC domain PGA_cap PF09587.5 KOO33022.1 - 4.4e-36 124.5 0.0 7.5e-36 123.7 0.0 1.3 1 0 0 1 1 1 1 Bacterial capsule synthesis protein PGA_cap 2OG-FeII_Oxy_3 PF13640.1 KOO33026.1 - 2.2e-10 40.9 0.2 2e-09 37.8 0.1 2.4 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO33026.1 - 9.6e-09 35.4 0.0 2e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Galactosyl_T PF01762.16 KOO33026.1 - 0.019 14.5 0.0 0.047 13.3 0.0 1.6 2 0 0 2 2 2 0 Galactosyltransferase Chloroa_b-bind PF00504.16 KOO33027.1 - 1.6e-35 122.6 0.1 2.2e-35 122.2 0.1 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Mg_trans_NIPA PF05653.9 KOO33029.1 - 3.8e-14 52.3 11.7 5.2e-14 51.9 8.1 1.2 1 0 0 1 1 1 1 Magnesium transporter NIPA SepZ PF06066.6 KOO33029.1 - 2.5 8.1 9.4 3.8 7.5 0.5 3.3 3 0 0 3 3 3 0 SepZ Cullin PF00888.17 KOO33030.1 - 7.3e-188 625.7 4.8 9.7e-188 625.3 3.3 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 KOO33030.1 - 3.3e-29 100.4 0.9 3.3e-29 100.4 0.6 2.0 2 0 0 2 2 2 1 Cullin protein neddylation domain HTH_IclR PF09339.5 KOO33030.1 - 0.012 15.2 0.0 0.071 12.7 0.0 2.5 2 0 0 2 2 2 0 IclR helix-turn-helix domain TrmB PF01978.14 KOO33030.1 - 0.055 13.1 0.1 13 5.6 0.0 3.0 3 0 0 3 3 3 0 Sugar-specific transcriptional regulator TrmB Trehalase PF01204.13 KOO33031.1 - 1.4e-10 40.5 2.1 2.8e-08 32.8 0.5 2.2 2 0 0 2 2 2 2 Trehalase Glyco_hydro_63 PF03200.11 KOO33031.1 - 4.1e-10 38.1 0.0 4.9e-10 37.9 0.0 1.1 1 0 0 1 1 1 1 Mannosyl oligosaccharide glucosidase NCA2 PF08637.5 KOO33033.1 - 1.5e-10 40.4 0.0 5.1e-10 38.7 0.0 1.7 1 1 0 1 1 1 1 ATP synthase regulation protein NCA2 Form_Nir_trans PF01226.12 KOO33034.1 - 1.5e-69 233.7 21.7 1.7e-69 233.5 15.1 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter Sec63 PF02889.11 KOO33035.1 - 2e-26 92.9 0.0 2.9e-26 92.4 0.0 1.2 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.24 KOO33035.1 - 5.9e-23 81.2 0.0 1e-22 80.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 KOO33035.1 - 1.4e-07 31.5 0.0 2.7e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 KOO33035.1 - 1.8e-07 30.9 0.0 3.7e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HHH_5 PF14520.1 KOO33035.1 - 0.00056 20.0 0.2 0.0019 18.3 0.1 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix domain AAA_19 PF13245.1 KOO33035.1 - 0.0012 18.4 0.1 0.014 15.1 0.0 2.9 2 0 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 KOO33035.1 - 0.0052 16.9 0.0 0.023 14.8 0.0 2.0 2 1 0 2 2 2 1 AAA domain UvrD-helicase PF00580.16 KOO33035.1 - 0.0056 16.0 0.0 0.0092 15.3 0.0 1.3 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain T2SE PF00437.15 KOO33035.1 - 0.0059 15.5 0.0 0.013 14.4 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein SNF2_N PF00176.18 KOO33035.1 - 0.009 14.8 0.0 0.015 14.1 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF1858 PF08984.6 KOO33035.1 - 0.047 13.3 0.0 0.14 11.8 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1858) zf-UBR PF02207.15 KOO33036.1 - 2.7e-20 71.8 10.8 5.1e-20 70.9 7.5 1.5 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Ank_4 PF13637.1 KOO33036.1 - 0.029 14.8 0.0 0.12 12.9 0.0 2.0 2 0 0 2 2 2 0 Ankyrin repeats (many copies) DUF779 PF05610.6 KOO33036.1 - 0.048 13.6 1.7 0.1 12.5 1.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF779) Ank_2 PF12796.2 KOO33036.1 - 0.08 13.2 0.1 0.29 11.5 0.0 1.9 3 0 0 3 3 3 0 Ankyrin repeats (3 copies) AAA_9 PF12781.2 KOO33040.1 - 3.2e-14 52.3 0.0 5.1e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 Dynein_heavy PF03028.10 KOO33040.1 - 4.8e-05 21.6 0.0 7.3e-05 21.0 0.0 1.3 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor AAA_6 PF12774.2 KOO33041.1 - 3.5e-81 272.1 0.1 5.3e-81 271.5 0.1 1.2 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 AAA_9 PF12781.2 KOO33041.1 - 4.8e-08 32.1 0.0 6.6e-08 31.6 0.0 1.2 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_5 PF07728.9 KOO33041.1 - 0.058 13.1 0.0 1.4 8.6 0.0 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.10 KOO33042.1 - 8.6e-33 113.3 0.0 9.6e-33 113.1 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor ART PF01129.13 KOO33043.1 - 0.0094 15.0 0.0 0.044 12.8 0.0 1.8 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase Cation_ATPase_N PF00690.21 KOO33044.1 - 3.2e-05 23.3 0.0 7e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus DUF3182 PF11379.3 KOO33044.1 - 0.11 11.1 0.2 0.17 10.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3182) DUF2721 PF11026.3 KOO33044.1 - 7.7 6.1 9.3 0.31 10.6 1.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) KH_1 PF00013.24 KOO33046.1 - 2.3e-20 71.9 5.1 6.9e-10 38.4 0.7 2.7 2 0 0 2 2 2 2 KH domain NYD-SP28_assoc PF14775.1 KOO33046.1 - 2.4e-12 46.3 0.1 2.4e-12 46.3 0.0 2.6 3 0 0 3 3 3 1 Sperm tail C-terminal domain KH_3 PF13014.1 KOO33046.1 - 4e-09 35.9 6.0 0.00068 19.2 0.3 3.8 3 0 0 3 3 3 2 KH domain NYD-SP28 PF14772.1 KOO33046.1 - 5.7e-09 36.0 16.1 5.7e-09 36.0 11.1 5.0 3 2 0 3 3 3 1 Sperm tail Agenet PF05641.7 KOO33046.1 - 9e-07 28.9 1.3 0.00034 20.7 0.1 3.4 3 0 0 3 3 3 1 Agenet domain KH_2 PF07650.12 KOO33046.1 - 9.8e-06 25.0 2.1 0.067 12.7 0.5 3.4 1 1 2 3 3 3 2 KH domain KH_4 PF13083.1 KOO33046.1 - 0.00047 19.7 4.2 0.16 11.6 0.1 3.4 3 0 0 3 3 3 2 KH domain VCBS PF13517.1 KOO33048.1 - 1.6e-149 486.3 207.6 2.3e-13 50.2 4.0 18.2 5 4 12 17 17 17 17 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO33048.1 - 4.2e-115 373.2 207.0 9.1e-07 28.3 0.9 22.5 22 0 0 22 22 22 22 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO33048.1 - 7.6e-33 113.4 90.2 0.17 11.3 0.0 22.2 8 4 14 22 22 22 20 Insecticide toxin TcdB middle/N-terminal region GCC2_GCC3 PF07699.8 KOO33048.1 - 3.1e-22 77.9 125.8 9.9e-06 25.0 0.5 16.0 7 1 10 17 17 17 12 GCC2 and GCC3 NCD3G PF07562.9 KOO33048.1 - 0.0001 21.9 18.1 0.00068 19.3 3.1 11.8 14 1 0 14 14 14 3 Nine Cysteines Domain of family 3 GPCR EphA2_TM PF14575.1 KOO33048.1 - 0.39 11.1 0.1 0.89 9.9 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain EF-hand_7 PF13499.1 KOO33049.1 - 3.7e-21 75.0 0.6 9e-10 38.5 0.0 3.5 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO33049.1 - 2.5e-18 64.2 3.3 0.001 18.7 0.1 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.27 KOO33049.1 - 6.1e-17 59.5 4.1 0.0002 20.4 0.1 4.7 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.1 KOO33049.1 - 3.1e-12 45.2 7.0 0.005 16.1 0.2 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO33049.1 - 5.1e-07 29.2 5.7 1.4e-05 24.6 0.1 4.0 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_10 PF14788.1 KOO33049.1 - 0.014 15.0 0.4 21 4.8 0.0 3.4 3 0 0 3 3 3 0 EF hand SPARC_Ca_bdg PF10591.4 KOO33049.1 - 0.063 13.3 0.0 0.25 11.3 0.0 1.9 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region DSRB PF10781.4 KOO33050.1 - 0.11 12.0 0.1 5.2 6.6 0.0 2.3 2 0 0 2 2 2 0 Dextransucrase DSRB Ion_trans PF00520.26 KOO33052.1 - 8e-111 368.0 47.2 3.5e-39 134.1 1.3 4.3 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 KOO33052.1 - 1.4e-06 27.0 41.3 0.0007 18.1 4.8 4.7 4 1 0 4 4 4 3 Polycystin cation channel NESP55 PF06390.7 KOO33053.1 - 0.25 10.6 0.9 0.35 10.2 0.6 1.1 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) NDK PF00334.14 KOO33055.1 - 4.5e-25 88.0 0.0 7.1e-25 87.3 0.0 1.2 1 0 0 1 1 1 1 Nucleoside diphosphate kinase DUF563 PF04577.9 KOO33055.1 - 0.00042 20.2 0.1 0.00067 19.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) DUF719 PF05334.8 KOO33056.1 - 0.086 12.8 0.3 1.9 8.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF719) M20_dimer PF07687.9 KOO33056.1 - 0.15 11.8 0.1 13 5.5 0.0 2.6 3 0 0 3 3 3 0 Peptidase dimerisation domain Dimer_Tnp_hAT PF05699.9 KOO33057.1 - 1.3e-05 24.6 0.2 3.8e-05 23.2 0.1 1.8 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region V-SNARE_C PF12352.3 KOO33058.1 - 8.3e-08 32.1 6.2 1.2e-07 31.6 4.3 1.2 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus MARVEL PF01284.18 KOO33058.1 - 0.00048 19.9 4.0 0.092 12.5 0.6 3.0 3 0 0 3 3 3 1 Membrane-associating domain TRP PF06011.7 KOO33058.1 - 0.015 13.8 0.1 0.03 12.9 0.1 1.3 1 1 0 1 1 1 0 Transient receptor potential (TRP) ion channel Na_sulph_symp PF00939.14 KOO33058.1 - 0.016 14.0 0.1 0.021 13.6 0.1 1.2 1 0 0 1 1 1 0 Sodium:sulfate symporter transmembrane region Synaptobrevin PF00957.16 KOO33058.1 - 0.036 13.6 0.2 0.036 13.6 0.1 2.0 2 0 0 2 2 1 0 Synaptobrevin DUF2721 PF11026.3 KOO33058.1 - 0.039 13.5 0.1 0.039 13.5 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) CitMHS PF03600.11 KOO33058.1 - 0.042 12.4 0.6 0.062 11.8 0.4 1.2 1 0 0 1 1 1 0 Citrate transporter MscS_TM PF12794.2 KOO33058.1 - 0.046 12.3 1.3 0.14 10.7 0.4 1.9 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 Sec20 PF03908.8 KOO33058.1 - 0.046 13.4 0.4 0.099 12.3 0.0 1.8 2 0 0 2 2 2 0 Sec20 DUF2077 PF09850.4 KOO33058.1 - 0.061 12.7 0.3 0.47 9.8 0.0 2.4 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2077) DUF1345 PF07077.6 KOO33058.1 - 0.078 12.4 0.1 0.34 10.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1345) EIID-AGA PF03613.9 KOO33058.1 - 0.12 11.2 0.0 0.12 11.2 0.0 1.6 2 0 0 2 2 1 0 PTS system mannose/fructose/sorbose family IID component DUF912 PF06024.7 KOO33058.1 - 0.21 11.6 1.1 0.42 10.6 0.0 2.0 2 0 0 2 2 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF1469 PF07332.6 KOO33058.1 - 0.97 9.1 5.3 3.4 7.4 0.8 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1469) Tetraspannin PF00335.15 KOO33058.1 - 1.2 8.3 7.2 4.8 6.3 4.1 2.0 2 0 0 2 2 2 0 Tetraspanin family ABC2_membrane_4 PF12730.2 KOO33058.1 - 4.9 6.2 9.1 11 5.0 6.3 1.7 1 1 0 1 1 1 0 ABC-2 family transporter protein DUF4131 PF13567.1 KOO33058.1 - 9.2 5.6 13.7 2 7.7 3.8 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) NT-C2 PF10358.4 KOO33059.1 - 1.6e-06 27.6 0.0 3.9e-06 26.4 0.0 1.6 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins MAD PF05557.8 KOO33059.1 - 0.0029 15.7 2.6 0.0041 15.2 1.8 1.2 1 0 0 1 1 1 1 Mitotic checkpoint protein COG5 PF10392.4 KOO33059.1 - 0.026 14.4 2.7 0.026 14.4 1.8 2.1 2 1 0 2 2 2 0 Golgi transport complex subunit 5 Cortex-I_coil PF09304.5 KOO33059.1 - 1.8 8.6 9.6 3 7.9 0.1 3.1 2 1 1 3 3 3 0 Cortexillin I, coiled coil Cupin_3 PF05899.7 KOO33060.1 - 4.2e-09 35.6 0.1 1.2e-08 34.2 0.1 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF861) UPF0167 PF03691.9 KOO33060.1 - 0.0034 16.8 1.2 0.0048 16.3 0.8 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0167) UPF0066 PF01980.11 KOO33061.1 - 1.4e-17 63.7 0.1 5.1e-10 39.3 0.1 2.2 1 1 1 2 2 2 2 Uncharacterised protein family UPF0066 PgpA PF04608.8 KOO33062.1 - 0.011 15.5 0.2 0.014 15.1 0.1 1.2 1 0 0 1 1 1 0 Phosphatidylglycerophosphatase A Chordopox_A35R PF05989.7 KOO33062.1 - 0.091 12.3 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Chordopoxvirus A35R protein Ion_trans PF00520.26 KOO33063.1 - 6.2e-16 58.2 9.0 6.2e-16 58.2 6.2 1.6 2 0 0 2 2 2 1 Ion transport protein cNMP_binding PF00027.24 KOO33063.1 - 8.9e-14 51.0 0.0 6.5e-13 48.3 0.0 2.3 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.11 KOO33063.1 - 4.4e-11 42.3 3.9 4.4e-11 42.3 2.7 2.2 2 1 0 2 2 2 1 Ion channel Ion_trans_N PF08412.5 KOO33063.1 - 0.0021 17.3 0.0 0.0068 15.6 0.0 1.8 1 0 0 1 1 1 1 Ion transport protein N-terminal CMAS PF02353.15 KOO33064.1 - 0.11 11.5 0.4 0.14 11.2 0.3 1.0 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase ShK PF01549.19 KOO33065.1 - 3e-13 49.8 22.7 3.1e-09 37.0 5.0 3.2 3 0 0 3 3 3 2 ShK domain-like LRR_4 PF12799.2 KOO33066.1 - 2e-26 91.0 19.2 2.3e-05 23.9 0.0 6.3 2 1 4 6 6 6 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO33066.1 - 9.9e-20 70.0 19.7 1.5e-06 27.8 0.5 5.3 2 2 4 6 6 6 6 Leucine rich repeat LRR_1 PF00560.28 KOO33066.1 - 1.2e-18 64.2 18.8 0.1 12.6 0.0 10.0 10 0 0 10 10 10 6 Leucine Rich Repeat LRR_6 PF13516.1 KOO33066.1 - 8.2e-08 31.5 22.7 0.027 14.4 0.0 8.8 9 1 1 10 10 10 2 Leucine Rich repeat LRR_7 PF13504.1 KOO33066.1 - 4.8e-05 22.9 17.1 9.9 6.8 0.0 8.7 10 0 0 10 10 10 3 Leucine rich repeat EF-hand_1 PF00036.27 KOO33067.1 - 6.6e-32 106.3 14.0 1.2e-07 30.4 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO33067.1 - 3.5e-30 103.9 4.2 9e-15 54.5 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO33067.1 - 3.2e-27 93.9 8.5 2.5e-12 46.1 0.1 3.9 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO33067.1 - 4e-25 85.3 5.6 1e-06 28.0 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO33067.1 - 6.4e-24 82.1 11.2 1.7e-06 27.1 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.1 KOO33067.1 - 1.6e-09 37.5 0.1 5.3e-05 23.0 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 KOO33067.1 - 2.2e-05 24.1 2.3 0.011 15.5 0.1 2.7 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO33067.1 - 5.2e-05 23.2 0.0 0.18 11.8 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.8 KOO33067.1 - 8.5e-05 22.3 2.2 0.39 10.4 0.8 2.7 1 1 1 2 2 2 2 Tellurite resistance protein TerB UPF0154 PF03672.8 KOO33067.1 - 0.0012 18.3 0.1 0.87 9.2 0.1 2.5 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.5 KOO33067.1 - 0.0029 17.5 0.3 0.018 14.9 0.0 2.2 2 1 0 2 2 2 1 Ca2+ insensitive EF hand DUF533 PF04391.7 KOO33067.1 - 1.2 8.4 5.5 2.5 7.4 0.1 2.7 2 1 2 4 4 4 0 Protein of unknown function (DUF533) EF-hand_5 PF13202.1 KOO33068.1 - 3.2e-134 430.8 151.0 2.2e-06 26.7 0.1 28.1 12 12 16 28 28 28 28 EF hand EF-hand_1 PF00036.27 KOO33068.1 - 2.5e-116 370.4 141.9 2e-05 23.5 0.3 28.1 10 10 18 28 28 28 28 EF hand EF-hand_6 PF13405.1 KOO33068.1 - 8.8e-108 342.6 139.0 3.2e-05 23.4 0.2 28.0 9 9 19 28 28 28 28 EF-hand domain EF-hand_7 PF13499.1 KOO33068.1 - 3.7e-87 286.4 106.7 6.6e-08 32.5 0.6 23.4 3 3 14 17 17 17 17 EF-hand domain pair EF-hand_8 PF13833.1 KOO33068.1 - 1.1e-61 204.2 126.8 0.0042 16.6 0.1 27.9 13 13 15 28 28 28 27 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO33068.1 - 2.5e-10 40.3 39.1 0.7 9.9 0.0 18.9 1 1 13 15 15 15 2 Secreted protein acidic and rich in cysteine Ca binding region SHOCT PF09851.4 KOO33068.1 - 1.5e-09 36.9 24.6 3.1 7.3 0.1 15.1 20 0 0 20 20 20 3 Short C-terminal domain EF-hand_4 PF12763.2 KOO33068.1 - 1.3e-06 28.0 41.1 0.12 12.1 0.1 12.9 2 2 11 15 15 15 3 Cytoskeletal-regulatory complex EF hand EFhand_Ca_insen PF08726.5 KOO33068.1 - 6.5e-05 22.8 3.0 19 5.3 0.0 6.4 6 0 0 6 6 6 0 Ca2+ insensitive EF hand PMBR PF09373.5 KOO33068.1 - 0.00043 20.1 6.4 1.4e+02 2.6 0.0 9.9 15 0 0 15 15 15 0 Pseudomurein-binding repeat DUF2782 PF11191.3 KOO33068.1 - 0.0014 18.5 0.5 49 3.9 0.0 6.7 6 3 3 9 9 9 0 Protein of unknown function (DUF2782) Phage_XkdX PF09693.5 KOO33068.1 - 0.091 12.2 13.2 95 2.6 0.0 9.5 14 0 0 14 14 14 0 Phage uncharacterised protein (Phage_XkdX) Cbl_N2 PF02761.9 KOO33068.1 - 1.6 8.8 5.2 5.6 7.1 0.0 4.5 5 1 0 5 5 5 0 CBL proto-oncogene N-terminus, EF hand-like domain DUF3192 PF11399.3 KOO33068.1 - 2.2 8.2 5.7 1e+02 2.8 0.1 5.7 3 2 2 5 5 5 0 Protein of unknown function (DUF3192) SPRY PF00622.23 KOO33069.1 - 0.052 13.6 0.0 0.16 12.1 0.0 1.8 1 1 0 1 1 1 0 SPRY domain TPT PF03151.11 KOO33070.1 - 0.0006 19.4 6.7 0.0006 19.4 4.7 2.7 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 KOO33070.1 - 0.00082 19.4 19.5 0.036 14.1 3.7 2.3 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.6 KOO33070.1 - 0.002 17.1 10.8 0.082 11.8 1.7 2.2 2 0 0 2 2 2 2 UAA transporter family Dimer_Tnp_hAT PF05699.9 KOO33072.1 - 1.6e-06 27.6 0.1 1.7e-06 27.5 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region UBA PF00627.26 KOO33073.1 - 0.0092 15.7 2.3 1 9.3 0.1 2.9 1 1 2 3 3 3 2 UBA/TS-N domain DUF2381 PF09544.5 KOO33073.1 - 0.016 14.3 0.1 0.025 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2381) ZZ PF00569.12 KOO33073.1 - 0.16 11.5 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 Zinc finger, ZZ type Nucleotid_trans PF03407.11 KOO33074.1 - 1.6e-09 37.9 0.0 2.9e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase NACHT PF05729.7 KOO33075.1 - 1.1e-05 25.1 0.0 3.6e-05 23.4 0.0 1.9 1 1 0 1 1 1 1 NACHT domain AAA_19 PF13245.1 KOO33075.1 - 0.00022 20.9 0.0 0.0014 18.3 0.2 2.2 2 0 0 2 2 2 1 Part of AAA domain UvrD-helicase PF00580.16 KOO33075.1 - 0.018 14.3 0.0 0.053 12.8 0.0 1.7 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA PF00004.24 KOO33075.1 - 0.061 13.5 0.0 0.24 11.5 0.0 1.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.17 KOO33075.1 - 0.12 11.1 0.3 0.26 10.1 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain LRR_4 PF12799.2 KOO33076.1 - 1.3e-22 78.9 28.0 0.00016 21.2 0.1 9.6 7 2 1 9 9 9 8 Leucine Rich repeats (2 copies) Amidohydro_4 PF13147.1 KOO33076.1 - 2.6e-14 53.9 5.8 9.9e-13 48.7 1.4 2.9 2 1 0 2 2 2 1 Amidohydrolase Amidohydro_1 PF01979.15 KOO33076.1 - 2.1e-13 50.6 0.0 2.5e-08 33.9 0.0 2.5 2 0 0 2 2 2 2 Amidohydrolase family LRR_8 PF13855.1 KOO33076.1 - 3.8e-10 39.3 31.4 2.3e-05 24.0 0.5 8.3 5 3 4 9 9 9 5 Leucine rich repeat Amidohydro_5 PF13594.1 KOO33076.1 - 5.2e-09 35.7 0.5 1.6e-08 34.2 0.4 1.9 1 0 0 1 1 1 1 Amidohydrolase LRR_6 PF13516.1 KOO33076.1 - 2.1e-08 33.3 34.8 0.12 12.5 0.4 11.9 11 0 0 11 11 11 2 Leucine Rich repeat LRR_1 PF00560.28 KOO33076.1 - 4.9e-07 28.9 22.9 20 5.6 0.1 13.3 14 0 0 14 14 13 0 Leucine Rich Repeat Miro PF08477.8 KOO33076.1 - 4.5e-05 23.9 0.0 0.00012 22.6 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO33076.1 - 0.00014 21.1 0.0 0.0003 20.0 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family Amidohydro_3 PF07969.6 KOO33076.1 - 0.00037 19.8 1.7 0.018 14.3 0.0 2.8 3 0 0 3 3 3 1 Amidohydrolase family Ras PF00071.17 KOO33076.1 - 0.00075 18.9 0.0 0.0019 17.6 0.0 1.7 1 0 0 1 1 1 1 Ras family GTP_EFTU PF00009.22 KOO33076.1 - 0.017 14.5 0.0 0.1 12.0 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOO33076.1 - 0.041 13.8 0.0 0.22 11.4 0.0 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase LRR_7 PF13504.1 KOO33076.1 - 3.7 8.1 27.6 66 4.3 0.0 11.2 13 0 0 13 13 11 0 Leucine rich repeat LRR_6 PF13516.1 KOO33077.1 - 4.2e-15 54.0 10.9 0.031 14.3 0.1 10.7 11 0 0 11 11 11 4 Leucine Rich repeat LRR_1 PF00560.28 KOO33077.1 - 8.9e-12 43.3 0.0 1.9 8.8 0.0 7.7 7 0 0 7 7 7 2 Leucine Rich Repeat LRR_4 PF12799.2 KOO33077.1 - 8e-09 34.9 0.4 0.047 13.3 0.0 6.1 6 0 0 6 6 6 2 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO33077.1 - 8.3e-07 28.2 6.2 4 8.0 0.1 7.5 9 0 0 9 9 9 2 Leucine rich repeat LRR_8 PF13855.1 KOO33077.1 - 1.3e-05 24.8 0.2 3 7.6 0.0 5.9 5 1 0 5 5 5 1 Leucine rich repeat Skp1 PF01466.14 KOO33077.1 - 0.0044 17.0 0.1 0.0044 17.0 0.0 1.9 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Metal_CEHH PF14455.1 KOO33077.1 - 0.012 15.0 0.0 0.036 13.4 0.0 1.6 1 1 1 2 2 2 0 Predicted metal binding domain FIBP PF05427.6 KOO33077.1 - 0.095 11.9 0.2 0.85 8.7 0.0 2.0 2 0 0 2 2 2 0 Acidic fibroblast growth factor binding (FIBP) Dispanin PF04505.7 KOO33077.1 - 3.3 7.3 8.2 22 4.6 0.0 4.1 4 0 0 4 4 4 0 Interferon-induced transmembrane protein DUF937 PF06078.6 KOO33077.1 - 5 7.3 9.2 6.6 6.9 0.1 4.2 2 1 2 5 5 5 0 Bacterial protein of unknown function (DUF937) Methyltransf_24 PF13578.1 KOO33078.1 - 1.2e-11 45.3 0.2 1.1e-09 39.0 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO33078.1 - 6.3e-10 39.6 0.0 1.1e-09 38.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.7 KOO33078.1 - 3.1e-07 29.9 0.0 4e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Cephalosporin hydroxylase Methyltransf_31 PF13847.1 KOO33078.1 - 9e-06 25.3 0.0 1.2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO33078.1 - 0.0002 21.7 0.0 0.00039 20.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO33078.1 - 0.00034 21.0 0.0 0.00068 20.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO33078.1 - 0.0017 18.3 0.1 0.02 14.9 0.1 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO33078.1 - 0.077 13.3 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain FerA PF08165.6 KOO33079.1 - 0.064 12.9 0.0 0.17 11.5 0.0 1.6 1 0 0 1 1 1 0 FerA (NUC095) domain Asp-B-Hydro_N PF05279.6 KOO33088.1 - 2.4 7.9 13.8 4.1 7.1 9.6 1.5 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF566 PF04484.7 KOO33089.1 - 2.8 7.3 9.3 5.1 6.5 6.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF566) WD40 PF00400.27 KOO33091.1 - 3.9e-53 175.5 11.8 4.2e-13 48.6 0.1 4.2 4 0 0 4 4 4 4 WD domain, G-beta repeat PD40 PF07676.7 KOO33091.1 - 5.2e-11 41.9 0.1 0.11 12.2 0.0 4.3 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOO33091.1 - 1.9e-06 27.7 0.1 0.00032 20.4 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.1 KOO33091.1 - 6.5e-05 22.1 1.0 1.4 7.9 0.0 3.5 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal DUF3312 PF11768.3 KOO33091.1 - 6.8e-05 21.2 0.0 0.027 12.6 0.0 2.7 1 1 1 2 2 2 2 Protein of unknown function (DUF3312) BBS2_Mid PF14783.1 KOO33091.1 - 0.0023 17.6 0.3 2.8 7.7 0.0 3.6 2 2 1 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Gmad1 PF10647.4 KOO33091.1 - 0.0055 16.1 0.0 1.1 8.6 0.0 3.3 1 1 2 3 3 3 1 Lipoprotein LpqB beta-propeller domain Dfp1_Him1_M PF08630.5 KOO33091.1 - 0.0062 16.3 1.0 4.8 6.9 0.0 2.8 3 1 0 3 3 3 2 Dfp1/Him1, central region rOmpB PF12334.3 KOO33091.1 - 0.009 15.4 2.2 2.6 7.3 0.1 3.5 1 1 1 3 3 3 1 Rickettsia outer membrane protein B Nucleoporin_N PF08801.6 KOO33091.1 - 0.016 13.9 2.3 2.5 6.7 0.2 2.8 1 1 2 3 3 3 0 Nup133 N terminal like 3-dmu-9_3-mt PF06983.8 KOO33091.1 - 0.028 14.7 0.1 35 4.7 0.0 3.7 1 1 3 4 4 4 0 3-demethylubiquinone-9 3-methyltransferase Proteasome_A_N PF10584.4 KOO33091.1 - 0.089 12.1 2.0 1.2e+02 2.1 0.0 4.0 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature DCX PF03607.12 KOO33091.1 - 0.11 12.0 0.0 2.1 7.9 0.0 2.9 3 1 1 4 4 4 0 Doublecortin DUF1769 PF08588.5 KOO33092.1 - 0.00077 19.3 0.0 0.002 18.0 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) EF-hand_1 PF00036.27 KOO33093.1 - 6.3e-26 87.6 8.4 0.00022 20.3 0.2 7.4 5 2 2 7 7 7 6 EF hand EF-hand_7 PF13499.1 KOO33093.1 - 6.1e-23 80.7 9.1 1.3e-05 25.2 0.8 7.5 4 1 2 6 6 6 5 EF-hand domain pair EF-hand_5 PF13202.1 KOO33093.1 - 1.1e-20 72.0 11.9 0.00026 20.1 0.3 6.3 4 2 2 6 6 6 5 EF hand EF-hand_6 PF13405.1 KOO33093.1 - 8e-18 62.6 15.7 0.013 15.2 0.3 7.9 7 2 2 9 9 9 6 EF-hand domain EF-hand_8 PF13833.1 KOO33093.1 - 1.6e-16 59.6 14.4 0.00018 21.0 0.2 7.1 5 2 2 7 7 7 5 EF-hand domain pair EF-hand_4 PF12763.2 KOO33093.1 - 0.0057 16.3 1.7 57 3.5 0.1 4.3 3 1 1 4 4 4 0 Cytoskeletal-regulatory complex EF hand SHOCT PF09851.4 KOO33093.1 - 0.2 11.1 3.3 4.9 6.7 0.1 3.9 4 0 0 4 4 4 0 Short C-terminal domain Asp_Arg_Hydrox PF05118.10 KOO33094.1 - 6e-38 130.2 0.0 7.7e-38 129.8 0.0 1.1 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase Cupin_2 PF07883.6 KOO33094.1 - 0.0013 18.1 0.0 0.0029 17.0 0.0 1.6 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.17 KOO33094.1 - 0.0059 16.0 0.0 0.011 15.1 0.0 1.4 1 1 0 1 1 1 1 Cupin Sec34 PF04136.10 KOO33095.1 - 0.8 9.3 5.4 1.2 8.7 0.1 3.0 3 0 0 3 3 3 0 Sec34-like family Surfac_D-trimer PF09006.6 KOO33095.1 - 6.7 6.5 9.1 0.29 10.8 0.6 3.1 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation SMN PF06003.7 KOO33097.1 - 0.32 10.0 2.1 0.54 9.3 1.4 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) DUF3381 PF11861.3 KOO33097.1 - 0.62 9.5 7.5 1 8.8 5.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) YqfQ PF14181.1 KOO33097.1 - 2.2 8.3 6.0 13 5.8 4.5 1.9 2 0 0 2 2 2 0 YqfQ-like protein CDC45 PF02724.9 KOO33097.1 - 6.6 4.6 8.2 9.6 4.1 5.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Ion_trans PF00520.26 KOO33098.1 - 3.5e-150 496.4 46.3 3.3e-47 160.3 5.6 4.2 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 KOO33098.1 - 2e-09 36.3 43.1 3.4e-06 25.7 0.9 8.1 6 3 2 9 9 9 5 Polycystin cation channel PGA2 PF07543.7 KOO33098.1 - 0.086 12.6 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 COP23 PF14218.1 KOO33098.1 - 0.46 10.0 0.0 0.85 9.1 0.0 1.3 1 0 0 1 1 1 0 Circadian oscillating protein COP23 Metallophos_C PF14008.1 KOO33099.1 - 4.1e-14 52.3 0.6 1.5e-13 50.6 0.1 2.2 2 1 1 3 3 3 1 Iron/zinc purple acid phosphatase-like protein C Metallophos PF00149.23 KOO33099.1 - 7.7e-07 28.7 0.0 1.9e-06 27.4 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase TIG PF01833.19 KOO33099.1 - 0.09 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 IPT/TIG domain Ion_trans_2 PF07885.11 KOO33100.1 - 8.4e-06 25.4 6.2 1.8e-05 24.3 4.3 1.5 1 0 0 1 1 1 1 Ion channel Ion_trans PF00520.26 KOO33100.1 - 0.048 12.8 5.9 0.17 11.1 4.1 1.8 1 1 0 1 1 1 0 Ion transport protein Filamin PF00630.14 KOO33101.1 - 3.6e-44 149.4 0.0 5.6e-15 55.7 0.0 5.9 5 1 0 5 5 5 5 Filamin/ABP280 repeat YtkA PF13115.1 KOO33101.1 - 0.035 14.4 0.8 4.5 7.7 0.0 3.8 3 0 0 3 3 3 0 YtkA-like LRR_6 PF13516.1 KOO33103.1 - 6.3e-05 22.6 0.3 0.039 14.0 0.0 3.7 3 0 0 3 3 3 1 Leucine Rich repeat LRR_5 PF13306.1 KOO33104.1 - 1.1e-61 206.2 0.6 1.6e-32 111.8 0.1 2.0 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO33104.1 - 9.1e-20 70.1 0.0 2.8e-07 30.1 0.0 3.2 1 1 2 3 3 3 3 Leucine rich repeat He_PIG PF05345.7 KOO33104.1 - 0.11 12.5 5.1 53 3.9 0.0 5.0 5 1 0 5 5 5 0 Putative Ig domain Ion_trans_2 PF07885.11 KOO33105.1 - 5.2e-31 106.1 11.8 8.2e-17 60.6 2.3 2.6 3 0 0 3 3 3 2 Ion channel EF-hand_5 PF13202.1 KOO33105.1 - 0.00012 21.2 3.0 0.042 13.2 0.5 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO33105.1 - 0.0008 19.0 0.6 0.057 13.3 0.1 2.7 2 0 0 2 2 2 1 EF-hand domain Ion_trans PF00520.26 KOO33105.1 - 0.0014 17.9 5.9 0.0052 16.0 1.1 2.2 2 0 0 2 2 2 1 Ion transport protein EF-hand_1 PF00036.27 KOO33105.1 - 0.007 15.5 1.4 0.49 9.8 0.1 2.6 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO33105.1 - 0.017 15.2 1.1 2 8.5 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain pair DUF3366 PF11846.3 KOO33105.1 - 1.4 8.8 3.7 3.8 7.3 0.4 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3366) cNMP_binding PF00027.24 KOO33106.1 - 5.4e-11 42.1 0.0 7.1e-07 28.9 0.0 2.7 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Ly49 PF08391.5 KOO33106.1 - 0.95 9.6 5.8 1.4 9.1 0.2 3.0 2 1 0 2 2 2 0 Ly49-like protein, N-terminal region GAS PF13851.1 KOO33106.1 - 4.1 6.5 39.9 1.4 8.0 9.6 4.0 3 2 0 3 3 3 0 Growth-arrest specific micro-tubule binding TIR_2 PF13676.1 KOO33107.1 - 0.0032 17.5 0.0 0.0088 16.1 0.0 1.7 1 0 0 1 1 1 1 TIR domain Lectin_C PF00059.16 KOO33107.1 - 0.0034 18.0 0.0 0.0087 16.6 0.0 1.7 1 0 0 1 1 1 1 Lectin C-type domain RR_TM4-6 PF06459.7 KOO33107.1 - 0.012 15.5 2.9 0.023 14.6 2.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1863 PF08937.6 KOO33107.1 - 0.052 13.6 0.0 0.35 10.9 0.0 2.1 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) Bac_chlorC PF02043.12 KOO33107.1 - 0.24 11.1 1.1 19 5.1 0.1 2.6 2 0 0 2 2 2 0 Bacteriochlorophyll C binding protein DUF3040 PF11239.3 KOO33107.1 - 6.2 6.9 6.3 3.1 7.9 0.5 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) PQQ_2 PF13360.1 KOO33109.1 - 4.9e-05 22.8 0.1 0.00089 18.7 0.1 2.3 1 1 0 1 1 1 1 PQQ-like domain PQQ_3 PF13570.1 KOO33109.1 - 0.0067 16.6 1.4 0.049 13.9 0.1 3.2 4 0 0 4 4 4 1 PQQ-like domain WD40 PF00400.27 KOO33109.1 - 0.032 14.1 3.6 36 4.4 0.0 4.4 4 0 0 4 4 4 0 WD domain, G-beta repeat PAS_7 PF12860.2 KOO33109.1 - 0.079 12.9 0.0 0.26 11.3 0.0 1.8 2 0 0 2 2 2 0 PAS fold PAP_fibrillin PF04755.7 KOO33111.1 - 1e-14 54.7 0.0 6.2e-14 52.1 0.0 1.9 1 1 0 1 1 1 1 PAP_fibrillin FYVE PF01363.16 KOO33112.1 - 1.2e-12 47.5 6.8 1.9e-12 46.8 4.7 1.3 1 0 0 1 1 1 1 FYVE zinc finger WW PF00397.21 KOO33112.1 - 0.00061 19.5 0.5 0.0013 18.5 0.0 1.8 2 0 0 2 2 2 1 WW domain Ank_2 PF12796.2 KOO33112.1 - 0.014 15.7 0.0 0.028 14.7 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO33112.1 - 0.035 14.3 0.5 1.2 9.4 0.1 3.1 3 0 0 3 3 3 0 Ankyrin repeats (many copies) FYVE_2 PF02318.11 KOO33112.1 - 0.039 13.8 3.7 0.067 13.0 2.6 1.3 1 0 0 1 1 1 0 FYVE-type zinc finger Siva PF05458.7 KOO33112.1 - 0.25 10.8 3.7 0.52 9.8 2.5 1.6 1 0 0 1 1 1 0 Cd27 binding protein (Siva) Abhydrolase_6 PF12697.2 KOO33114.1 - 6.3e-26 91.6 2.1 8.3e-26 91.2 1.4 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO33114.1 - 4.7e-10 39.4 0.0 9.6e-10 38.3 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO33114.1 - 8.3e-10 38.6 0.0 1.9e-06 27.6 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_3 PF07859.8 KOO33114.1 - 0.0048 16.4 0.0 0.0064 16.0 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.5 KOO33114.1 - 0.093 12.6 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein CDO_I PF05995.7 KOO33115.1 - 1.2e-21 76.6 0.0 1.7e-21 76.1 0.0 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I Cupin_2 PF07883.6 KOO33115.1 - 0.0014 18.0 0.2 1.7 8.1 0.0 2.6 1 1 1 2 2 2 2 Cupin domain Glyco_hydro_3 PF00933.16 KOO33117.1 - 1.5e-52 178.4 0.0 2.4e-52 177.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 KOO33117.1 - 6.9e-44 150.0 0.1 1.2e-43 149.3 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 KOO33117.1 - 8.8e-12 44.8 0.0 1.7e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Radical_SAM PF04055.16 KOO33117.1 - 0.0024 18.0 0.0 0.0043 17.2 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Pkinase PF00069.20 KOO33118.1 - 4.1e-38 131.0 0.0 5.7e-38 130.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33118.1 - 3e-31 108.4 0.0 4.7e-31 107.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO33118.1 - 8.2 6.0 8.9 0.34 10.6 0.2 2.8 3 1 0 3 3 3 0 Phosphotransferase enzyme family LRS4 PF10422.4 KOO33119.1 - 0.07 12.4 16.0 0.068 12.5 9.7 1.9 1 1 1 2 2 2 0 Monopolin complex subunit LRS4 AAA_13 PF13166.1 KOO33119.1 - 4.4 5.6 15.3 6.2 5.1 10.6 1.2 1 0 0 1 1 1 0 AAA domain Sulf_transp PF04143.9 KOO33120.1 - 1.3e-11 44.3 28.0 1.3e-08 34.7 5.8 5.6 6 1 1 7 7 7 2 Sulphur transport DUF4341 PF14241.1 KOO33120.1 - 1.3e-10 40.7 4.7 1.3e-10 40.7 3.3 3.6 4 0 0 4 4 4 1 Domain of unknown function (DUF4341) TPR_12 PF13424.1 KOO33121.1 - 1.5e-09 37.6 3.5 4e-09 36.2 0.2 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOO33121.1 - 3.9e-08 32.8 0.8 2.5e-07 30.2 0.1 2.4 2 0 0 2 2 2 1 TPR repeat TPR_10 PF13374.1 KOO33121.1 - 4.2e-07 29.6 0.0 0.05 13.5 0.0 4.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO33121.1 - 3.2e-06 26.6 1.4 0.002 17.9 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO33121.1 - 1.3e-05 25.4 3.6 0.099 12.9 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO33121.1 - 0.00065 19.2 5.4 0.0012 18.3 0.2 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO33121.1 - 0.0069 16.1 6.0 0.52 10.2 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO33121.1 - 0.1 12.4 0.7 1.3 9.0 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO33121.1 - 0.38 11.5 6.9 5.4 7.9 0.3 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat DNA_photolyase PF00875.13 KOO33122.1 - 5.4e-05 22.9 0.0 7.1e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 DNA photolyase Rubis-subs-bind PF09273.6 KOO33123.1 - 0.059 13.2 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Rubisco LSMT substrate-binding Peptidase_M16_C PF05193.16 KOO33124.1 - 2.7e-08 33.6 0.0 6.3e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 KOO33124.1 - 5.8e-06 26.1 0.0 1.1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) WD40 PF00400.27 KOO33125.1 - 8.3e-34 114.2 8.5 2e-11 43.2 0.3 4.8 5 0 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.3 KOO33125.1 - 0.00044 18.5 0.1 0.0014 16.8 0.1 1.7 1 1 0 1 1 1 1 Nucleoporin Nup120/160 DUF3312 PF11768.3 KOO33125.1 - 0.034 12.3 0.0 0.044 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3312) Kelch_6 PF13964.1 KOO33125.1 - 0.045 13.9 0.0 4.2 7.7 0.0 2.8 3 0 0 3 3 3 0 Kelch motif Nbas_N PF15492.1 KOO33125.1 - 0.1 11.7 0.2 0.55 9.2 0.0 2.2 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Peptidase_S41 PF03572.13 KOO33126.1 - 3.5e-20 72.0 0.0 5.7e-20 71.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S41 VCBS PF13517.1 KOO33127.1 - 5.2e-129 420.6 149.4 3e-14 53.1 3.8 12.4 1 1 11 12 12 12 12 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO33127.1 - 3.2e-70 230.3 114.1 4.6e-06 26.1 1.1 13.5 13 0 0 13 13 13 13 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO33127.1 - 2e-29 102.2 45.1 0.048 13.0 0.1 13.1 2 2 11 13 13 13 13 Insecticide toxin TcdB middle/N-terminal region Pkinase PF00069.20 KOO33127.1 - 1.4e-07 30.9 0.1 0.0093 15.1 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33127.1 - 0.00044 19.4 0.0 0.29 10.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase YuzL PF14115.1 KOO33127.1 - 0.067 13.4 27.9 17 5.8 0.0 11.4 13 0 0 13 13 13 0 YuzL-like protein EF-hand_5 PF13202.1 KOO33127.1 - 0.23 10.8 86.3 5.9 6.4 0.5 13.3 13 0 0 13 13 13 0 EF hand RE_NgoPII PF09521.5 KOO33127.1 - 0.37 9.5 1.1 1.2e+02 1.3 0.0 4.1 5 0 0 5 5 5 0 NgoPII restriction endonuclease DUF1391 PF07151.7 KOO33127.1 - 1.1 8.8 10.1 26 4.3 0.1 5.7 6 0 0 6 6 6 0 Protein of unknown function (DUF1391) SBBP PF06739.6 KOO33128.1 - 1.5e-13 50.2 38.9 0.0035 17.1 0.5 6.4 6 0 0 6 6 6 6 Beta-propeller repeat DUF3712 PF12505.3 KOO33128.1 - 0.0093 15.9 0.0 31 4.5 0.0 4.3 5 0 0 5 5 5 1 Protein of unknown function (DUF3712) NMU PF02070.10 KOO33128.1 - 0.079 12.4 6.6 64 3.1 0.1 4.6 4 0 0 4 4 4 0 Neuromedin U FAD_binding_9 PF08021.6 KOO33128.1 - 2.1 8.3 10.1 1.1e+02 2.8 0.0 4.7 5 0 0 5 5 5 0 Siderophore-interacting FAD-binding domain E1-E2_ATPase PF00122.15 KOO33129.1 - 7.8e-48 162.5 0.5 1.3e-47 161.7 0.3 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 KOO33129.1 - 4.3e-21 76.3 3.7 5.9e-20 72.6 2.6 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO33129.1 - 1.4e-06 28.6 0.0 7.4e-06 26.2 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 KOO33129.1 - 0.0057 16.2 0.1 0.0088 15.6 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF805 PF05656.9 KOO33129.1 - 0.017 14.9 1.6 0.027 14.2 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF805) MerC PF03203.9 KOO33129.1 - 0.16 12.3 7.4 0.051 13.9 2.1 2.5 2 1 0 2 2 2 0 MerC mercury resistance protein Glucos_trans_II PF14264.1 KOO33129.1 - 0.68 8.8 6.5 0.27 10.1 0.9 2.1 2 0 0 2 2 2 0 Glucosyl transferase GtrII Sec39 PF08314.6 KOO33131.1 - 1.4e-11 43.1 0.0 2.1e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 Secretory pathway protein Sec39 R3H PF01424.17 KOO33132.1 - 1.1e-05 24.9 0.0 4.4e-05 23.0 0.0 2.0 2 0 0 2 2 2 1 R3H domain Glyco_trans_1_2 PF13524.1 KOO33133.1 - 5.9e-07 29.6 0.0 1.2e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 AAA_11 PF13086.1 KOO33135.1 - 3.2e-16 59.6 0.0 1.1e-15 57.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.1 KOO33135.1 - 3.1e-14 52.8 0.0 5.6e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOO33135.1 - 4e-10 39.3 1.2 7.2e-09 35.2 0.1 2.8 2 0 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 KOO33135.1 - 2.1e-06 27.8 0.0 0.00028 21.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain Helicase_RecD PF05127.9 KOO33135.1 - 2.3e-06 27.3 0.0 0.0048 16.5 0.0 2.5 2 0 0 2 2 2 2 Helicase AAA_25 PF13481.1 KOO33135.1 - 2.7e-05 23.6 0.0 6e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.1 KOO33135.1 - 8.6e-05 22.1 0.1 0.049 13.2 0.0 2.8 2 1 0 2 2 2 1 AAA domain UvrD-helicase PF00580.16 KOO33135.1 - 9.1e-05 21.8 0.0 0.00021 20.7 0.0 1.6 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain FtsK_SpoIIIE PF01580.13 KOO33135.1 - 0.00035 20.1 0.0 0.00082 18.8 0.0 1.6 1 0 0 1 1 1 1 FtsK/SpoIIIE family Viral_helicase1 PF01443.13 KOO33135.1 - 0.00082 18.9 0.4 0.81 9.1 0.1 3.7 3 1 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_33 PF13671.1 KOO33135.1 - 0.0022 17.8 0.0 0.007 16.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.1 KOO33135.1 - 0.019 15.1 0.1 0.043 13.9 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_24 PF13479.1 KOO33135.1 - 0.021 14.4 0.0 0.043 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 KOO33135.1 - 0.03 13.7 0.0 0.051 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain DUF2075 PF09848.4 KOO33135.1 - 0.034 13.1 0.0 1.6 7.6 0.0 2.8 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) PhoH PF02562.11 KOO33135.1 - 0.062 12.5 0.0 0.13 11.4 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Phage_head_chap PF11113.3 KOO33136.1 - 0.024 14.5 0.0 0.052 13.4 0.0 1.5 1 0 0 1 1 1 0 Head assembly gene product RSS_P20 PF11757.3 KOO33136.1 - 0.052 13.6 0.0 0.082 13.0 0.0 1.2 1 0 0 1 1 1 0 Suppressor of RNA silencing P21-like FATC PF02260.15 KOO33136.1 - 0.071 12.5 0.1 0.14 11.6 0.1 1.4 1 0 0 1 1 1 0 FATC domain Trp_repressor PF01371.14 KOO33136.1 - 0.08 12.8 0.0 0.18 11.7 0.0 1.6 1 1 0 1 1 1 0 Trp repressor protein PSD3 PF07626.6 KOO33136.1 - 0.1 12.6 0.0 0.39 10.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1587) HTH_1 PF00126.22 KOO33136.1 - 0.13 12.0 0.5 5.7 6.7 0.0 2.4 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family Saccharop_dh PF03435.13 KOO33137.1 - 2.2e-11 43.4 0.1 1.5e-07 30.8 0.0 2.1 1 1 1 2 2 2 2 Saccharopine dehydrogenase Septin PF00735.13 KOO33138.1 - 7e-29 100.7 0.1 3.9e-22 78.5 0.1 2.2 2 0 0 2 2 2 2 Septin G-alpha PF00503.15 KOO33138.1 - 2.5e-06 26.4 0.0 2.5e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 G-protein alpha subunit AAA_16 PF13191.1 KOO33138.1 - 0.00012 22.1 7.9 0.00017 21.6 5.5 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 KOO33138.1 - 0.00016 21.8 0.1 0.00044 20.4 0.1 1.8 1 1 0 1 1 1 1 AAA domain GTP_EFTU PF00009.22 KOO33138.1 - 0.00022 20.7 0.4 2.2 7.7 0.0 3.2 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 KOO33138.1 - 0.00036 20.4 1.2 0.0018 18.1 0.3 2.3 2 1 0 2 2 1 1 Dynamin family ABC_tran PF00005.22 KOO33138.1 - 0.00048 20.4 0.0 0.00077 19.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter DUF572 PF04502.8 KOO33138.1 - 0.00074 18.8 5.6 0.00092 18.5 3.8 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF572) MMR_HSR1 PF01926.18 KOO33138.1 - 0.00093 19.1 0.0 0.025 14.5 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 KOO33138.1 - 0.0011 18.1 0.0 0.021 14.0 0.0 2.4 1 1 0 1 1 1 1 Protein of unknown function, DUF258 Spc7 PF08317.6 KOO33138.1 - 0.0032 16.1 7.7 0.0058 15.3 5.4 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein TMF_DNA_bd PF12329.3 KOO33138.1 - 0.0037 17.0 7.6 0.0095 15.7 5.3 1.7 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding T4SS PF07996.6 KOO33138.1 - 0.0045 16.8 1.8 0.0072 16.2 1.2 1.3 1 0 0 1 1 1 1 Type IV secretion system proteins V_ATPase_I PF01496.14 KOO33138.1 - 0.009 13.9 3.9 0.012 13.5 2.7 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Herpes_UL25 PF01499.11 KOO33138.1 - 0.011 14.0 6.4 0.016 13.5 4.4 1.2 1 0 0 1 1 1 0 Herpesvirus UL25 family AAA_10 PF12846.2 KOO33138.1 - 0.015 14.7 2.8 0.099 12.0 2.0 1.9 1 1 0 1 1 1 0 AAA-like domain AAA_33 PF13671.1 KOO33138.1 - 0.024 14.5 3.0 0.088 12.6 2.0 1.9 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 KOO33138.1 - 0.045 13.2 1.4 0.23 10.8 0.4 2.5 2 1 0 2 2 2 0 FtsK/SpoIIIE family Pox_A32 PF04665.7 KOO33138.1 - 0.056 12.7 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein NACHT PF05729.7 KOO33138.1 - 0.058 13.0 1.0 0.25 10.9 0.3 2.3 2 1 0 2 2 1 0 NACHT domain AAA_29 PF13555.1 KOO33138.1 - 0.11 12.0 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain PAS_4 PF08448.5 KOO33138.1 - 0.13 12.3 8.3 0.61 10.1 0.2 2.5 1 1 1 2 2 2 0 PAS fold Fib_alpha PF08702.5 KOO33138.1 - 0.15 12.1 8.5 0.055 13.5 2.3 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family AAA PF00004.24 KOO33138.1 - 0.25 11.5 1.6 2.8 8.1 0.1 2.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF724 PF05266.9 KOO33138.1 - 0.36 10.4 6.8 0.71 9.4 4.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) SF-assemblin PF06705.6 KOO33138.1 - 0.42 9.7 14.4 0.21 10.7 7.8 1.8 1 1 0 2 2 2 0 SF-assemblin/beta giardin APG6 PF04111.7 KOO33138.1 - 0.71 8.8 9.4 1.1 8.2 6.5 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 ERM PF00769.14 KOO33138.1 - 0.95 8.9 23.5 0.04 13.4 11.0 2.1 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Atg14 PF10186.4 KOO33138.1 - 1.1 8.1 11.2 1.9 7.3 7.7 1.4 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Med9 PF07544.8 KOO33138.1 - 1.7 8.4 13.2 6 6.6 8.2 2.3 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 IncA PF04156.9 KOO33138.1 - 2.5 7.6 10.9 4.5 6.8 7.6 1.4 1 0 0 1 1 1 0 IncA protein FUSC PF04632.7 KOO33138.1 - 2.8 6.2 9.0 4.8 5.4 6.2 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family BTV_NS2 PF04514.7 KOO33138.1 - 4.8 5.9 8.2 7.3 5.3 5.7 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 DivIC PF04977.10 KOO33138.1 - 7.2 6.1 13.2 0.26 10.8 3.3 2.5 1 1 1 2 2 2 0 Septum formation initiator IQ PF00612.22 KOO33141.1 - 0.0017 17.8 0.0 0.0079 15.7 0.0 2.3 1 0 0 1 1 1 1 IQ calmodulin-binding motif RasGAP PF00616.14 KOO33142.1 - 2.5e-33 115.4 0.0 3.4e-33 114.9 0.0 1.2 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Tubulin PF00091.20 KOO33143.1 - 3.5e-10 40.0 0.0 9.4e-10 38.6 0.0 1.6 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain EF-hand_1 PF00036.27 KOO33144.1 - 4.5e-23 78.7 1.0 9.9e-07 27.6 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 KOO33144.1 - 1.6e-19 67.9 0.4 1e-05 24.9 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.1 KOO33144.1 - 6.1e-19 66.4 3.7 9.4e-07 27.9 0.2 3.5 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.1 KOO33144.1 - 2.5e-18 65.9 2.6 3.2e-10 39.9 0.1 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO33144.1 - 6.4e-15 54.5 2.4 0.00046 19.7 0.1 3.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.2 KOO33144.1 - 5.9e-06 25.9 0.3 1.7 8.4 0.0 3.1 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO33144.1 - 0.00021 21.1 0.6 0.14 12.0 0.0 3.0 3 1 0 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO33144.1 - 0.0023 17.9 1.4 1.7 8.7 0.0 2.9 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Potyvirid-P3 PF13608.1 KOO33144.1 - 0.072 12.2 1.5 0.09 11.8 1.0 1.2 1 0 0 1 1 1 0 Protein P3 of Potyviral polyprotein p25-alpha PF05517.7 KOO33144.1 - 0.19 11.9 3.6 0.29 11.3 0.0 2.5 1 1 0 2 2 2 0 p25-alpha PDGLE PF13190.1 KOO33145.1 - 0.059 13.0 0.6 0.097 12.3 0.4 1.5 1 1 0 1 1 1 0 PDGLE domain ASFV_J13L PF05568.6 KOO33145.1 - 0.3 10.5 0.1 0.3 10.5 0.1 2.1 2 1 0 2 2 2 0 African swine fever virus J13L protein Tubulin PF00091.20 KOO33146.1 - 5e-07 29.7 0.7 5.1e-07 29.7 0.5 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.4 KOO33146.1 - 0.0011 18.9 0.0 0.0012 18.9 0.0 1.0 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain VCBS PF13517.1 KOO33148.1 - 7.6e-141 458.5 164.1 3.5e-14 52.8 4.1 13.6 1 1 12 13 13 13 13 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO33148.1 - 6.4e-67 219.8 146.1 2e-06 27.3 2.8 15.4 15 0 0 15 15 15 14 FG-GAP repeat Pkinase PF00069.20 KOO33148.1 - 2.4e-34 118.6 0.0 1.7e-16 60.1 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33148.1 - 8.1e-28 97.1 0.0 1.2e-27 96.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TcdB_toxin_midN PF12256.3 KOO33148.1 - 3.7e-23 81.8 57.1 0.11 11.8 0.1 14.2 1 1 13 14 14 14 13 Insecticide toxin TcdB middle/N-terminal region DUF4384 PF14326.1 KOO33148.1 - 1e-08 34.8 0.0 17 5.3 0.0 10.2 5 3 8 13 13 13 1 Domain of unknown function (DUF4384) DUF4537 PF15057.1 KOO33148.1 - 0.018 14.8 0.0 0.084 12.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4537) DUF4375 PF14300.1 KOO33148.1 - 0.45 10.5 1.6 5.2 7.0 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4375) Nuc_sug_transp PF04142.10 KOO33149.1 - 3e-37 128.0 9.4 4.7e-37 127.3 6.5 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.15 KOO33149.1 - 7.5e-05 22.7 7.4 7.5e-05 22.7 5.2 3.5 4 1 1 5 5 5 2 EamA-like transporter family UAA PF08449.6 KOO33149.1 - 0.00011 21.2 2.0 0.00011 21.2 1.4 1.6 2 0 0 2 2 2 1 UAA transporter family TPT PF03151.11 KOO33149.1 - 0.00045 19.9 13.1 0.02 14.5 3.4 3.5 3 0 0 3 3 3 2 Triose-phosphate Transporter family EmrE PF13536.1 KOO33149.1 - 0.0059 16.8 9.2 0.0059 16.8 6.4 3.6 1 1 0 2 2 2 1 Multidrug resistance efflux transporter MFS_1 PF07690.11 KOO33150.1 - 8.7e-20 70.7 30.4 8.7e-20 70.7 21.1 2.8 1 1 1 2 2 2 1 Major Facilitator Superfamily ACBP PF00887.14 KOO33150.1 - 1.1e-15 57.0 0.0 1.7e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 Acyl CoA binding protein Sugar_tr PF00083.19 KOO33150.1 - 2.1e-08 33.1 7.5 2.1e-08 33.1 5.2 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.15 KOO33150.1 - 9e-05 20.7 0.9 0.0002 19.6 0.6 1.5 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family TTL PF03133.10 KOO33154.1 - 1.2e-74 250.8 0.0 1.7e-74 250.4 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATP-grasp_3 PF02655.9 KOO33154.1 - 0.034 14.0 0.0 0.29 10.9 0.0 2.1 2 0 0 2 2 2 0 ATP-grasp domain ATPgrasp_YheCD PF14398.1 KOO33154.1 - 0.034 12.9 0.0 0.096 11.4 0.0 1.7 2 0 0 2 2 2 0 YheC/D like ATP-grasp ATPgrasp_ST PF14397.1 KOO33154.1 - 0.17 10.9 0.0 16 4.4 0.0 2.2 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp FhuF PF06276.7 KOO33155.1 - 0.093 12.6 0.2 1 9.3 0.0 2.3 3 0 0 3 3 3 0 Ferric iron reductase FhuF-like transporter Mg_trans_NIPA PF05653.9 KOO33156.1 - 2e-08 33.5 10.9 2.9e-05 23.2 2.0 2.2 2 0 0 2 2 2 2 Magnesium transporter NIPA Nucleotid_trans PF03407.11 KOO33156.1 - 1.1e-06 28.5 0.1 1.7e-06 27.9 0.1 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase EmrE PF13536.1 KOO33156.1 - 0.0088 16.2 4.0 0.0088 16.2 2.8 2.6 3 0 0 3 3 3 1 Multidrug resistance efflux transporter EamA PF00892.15 KOO33156.1 - 2.5 8.1 16.9 0.061 13.3 3.8 3.2 3 0 0 3 3 3 0 EamA-like transporter family Glyco_hydro_92 PF07971.7 KOO33158.1 - 4.2e-100 335.7 0.4 8e-100 334.8 0.3 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Chloroa_b-bind PF00504.16 KOO33159.1 - 1.6e-13 51.2 0.0 2e-13 50.8 0.0 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein bZIP_1 PF00170.16 KOO33160.1 - 2.6e-09 36.8 8.3 4.2e-09 36.2 5.7 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 KOO33160.1 - 1.2e-07 31.3 8.8 2e-07 30.7 6.1 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.12 KOO33160.1 - 1.7e-05 24.9 3.3 2.9e-05 24.2 2.3 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor Vps5 PF09325.5 KOO33160.1 - 0.013 14.7 0.3 0.02 14.1 0.2 1.2 1 0 0 1 1 1 0 Vps5 C terminal like DUF4618 PF15397.1 KOO33160.1 - 0.033 13.5 0.3 0.045 13.0 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) IncA PF04156.9 KOO33160.1 - 0.17 11.4 1.9 0.24 10.9 1.3 1.2 1 0 0 1 1 1 0 IncA protein PAH PF02671.16 KOO33161.1 - 6.8e-17 60.8 0.1 1.5e-16 59.7 0.1 1.6 1 0 0 1 1 1 1 Paired amphipathic helix repeat PHD PF00628.24 KOO33161.1 - 1.6e-08 34.0 8.9 1.6e-08 34.0 6.2 2.5 3 0 0 3 3 3 1 PHD-finger zf-CXXC PF02008.15 KOO33161.1 - 1.6e-05 24.6 0.2 1.6e-05 24.6 0.2 2.9 4 0 0 4 4 4 1 CXXC zinc finger domain Serglycin PF04360.7 KOO33161.1 - 0.01 15.5 0.9 0.026 14.2 0.6 1.7 1 0 0 1 1 1 0 Serglycin OmdA PF13376.1 KOO33161.1 - 0.019 14.6 0.2 0.047 13.3 0.1 1.6 1 0 0 1 1 1 0 Bacteriocin-protection, YdeI or OmpD-Associated Ank_2 PF12796.2 KOO33162.1 - 2.8e-54 181.4 12.8 2.3e-17 63.1 0.1 4.5 2 2 3 5 5 5 4 Ankyrin repeats (3 copies) Ank PF00023.25 KOO33162.1 - 2.6e-29 99.5 16.6 9e-05 22.0 0.0 7.9 8 0 0 8 8 8 6 Ankyrin repeat Ank_4 PF13637.1 KOO33162.1 - 7.7e-25 86.8 1.5 1.3e-08 35.1 0.0 6.0 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO33162.1 - 9.2e-21 71.8 1.5 0.0011 19.0 0.0 7.7 7 1 1 8 8 8 4 Ankyrin repeat Ank_5 PF13857.1 KOO33162.1 - 6.9e-18 64.2 12.7 1.8e-05 24.7 0.0 6.6 2 1 6 8 8 8 6 Ankyrin repeats (many copies) zf-PARP PF00645.13 KOO33163.1 - 6.3e-19 68.0 0.0 1.1e-18 67.2 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region SAP PF02037.22 KOO33163.1 - 4.9e-14 51.4 2.2 3.2e-08 32.8 0.1 2.5 2 0 0 2 2 2 2 SAP domain PADR1 PF08063.7 KOO33163.1 - 1.9e-08 33.5 1.2 1.9e-08 33.5 0.8 2.1 2 1 0 2 2 2 1 PADR1 (NUC008) domain HeH PF12949.2 KOO33163.1 - 0.038 13.5 0.3 0.22 11.0 0.0 2.5 2 1 0 2 2 2 0 HeH/LEM domain DNA_ligase_ZBD PF03119.11 KOO33163.1 - 0.083 12.6 0.7 1.1 9.0 0.1 2.7 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain DUF164 PF02591.10 KOO33163.1 - 0.11 12.3 0.9 9.6 6.1 0.0 2.6 2 0 0 2 2 2 0 Putative zinc ribbon domain Aa_trans PF01490.13 KOO33164.1 - 3.9e-44 150.7 9.5 4.9e-44 150.4 6.6 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF872 PF05915.7 KOO33164.1 - 5.5 6.8 5.9 7.9 6.3 0.2 3.3 3 0 0 3 3 3 0 Eukaryotic protein of unknown function (DUF872) Cyt-b5 PF00173.23 KOO33165.1 - 1.3e-17 63.2 0.0 1.9e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain WW PF00397.21 KOO33165.1 - 0.00038 20.2 0.0 0.001 18.8 0.0 1.8 1 0 0 1 1 1 1 WW domain Sugar_tr PF00083.19 KOO33166.1 - 0.00043 18.9 0.1 0.0008 18.0 0.1 1.5 1 0 0 1 1 1 1 Sugar (and other) transporter Multi_Drug_Res PF00893.14 KOO33166.1 - 0.00053 20.4 0.4 0.00084 19.7 0.3 1.3 1 0 0 1 1 1 1 Small Multidrug Resistance protein Sec2p PF06428.6 KOO33166.1 - 0.0068 16.2 2.8 0.0068 16.2 1.9 3.6 1 1 2 4 4 4 1 GDP/GTP exchange factor Sec2p HALZ PF02183.13 KOO33166.1 - 0.0076 15.9 0.6 0.033 13.9 0.4 2.2 1 0 0 1 1 1 1 Homeobox associated leucine zipper DivIC PF04977.10 KOO33166.1 - 0.01 15.3 0.5 0.01 15.3 0.3 4.0 2 2 1 4 4 4 0 Septum formation initiator CCDC92 PF14916.1 KOO33166.1 - 0.039 13.5 0.5 0.09 12.3 0.4 1.6 1 0 0 1 1 1 0 Coiled-coil domain of unknown function bZIP_2 PF07716.10 KOO33166.1 - 0.045 13.5 1.8 0.045 13.5 1.2 3.9 4 1 1 5 5 4 0 Basic region leucine zipper DUF3450 PF11932.3 KOO33166.1 - 0.051 12.8 19.8 0.039 13.2 4.0 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Prominin PF05478.6 KOO33166.1 - 0.27 8.7 2.6 0.33 8.4 1.8 1.2 1 0 0 1 1 1 0 Prominin DUF1664 PF07889.7 KOO33166.1 - 0.43 10.3 5.8 1.3 8.8 4.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF972 PF06156.8 KOO33166.1 - 0.5 10.7 16.5 0.27 11.5 1.4 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF972) DUF4618 PF15397.1 KOO33166.1 - 1.4 8.2 15.9 0.039 13.2 6.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) GAS PF13851.1 KOO33166.1 - 1.5 7.9 17.2 0.17 11.0 3.7 2.8 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding IncA PF04156.9 KOO33166.1 - 2.9 7.4 19.7 40 3.7 11.9 2.6 1 1 1 2 2 2 0 IncA protein PEARLI-4 PF05278.7 KOO33166.1 - 4.6 6.5 13.1 0.054 12.8 3.5 1.7 2 0 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) DUF4340 PF14238.1 KOO33167.1 - 0.12 12.0 0.1 0.2 11.3 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4340) GalKase_gal_bdg PF10509.4 KOO33168.1 - 8.4e-07 28.1 0.0 2.1e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.8 KOO33168.1 - 0.00011 22.3 0.3 0.00032 20.8 0.2 1.9 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.21 KOO33168.1 - 0.0024 17.8 1.0 0.01 15.8 0.7 2.1 1 0 0 1 1 1 1 GHMP kinases N terminal domain EF-hand_8 PF13833.1 KOO33170.1 - 2.9e-14 52.4 8.8 4.3e-11 42.2 0.8 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO33170.1 - 2.1e-13 48.4 6.1 6e-07 28.3 0.4 2.9 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 KOO33170.1 - 3.6e-12 46.2 0.5 1.2e-11 44.5 0.3 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO33170.1 - 7.9e-11 40.8 3.4 4.4e-06 26.1 0.1 3.0 3 0 0 3 3 3 2 EF-hand domain PH PF00169.24 KOO33170.1 - 1.9e-10 40.8 0.1 3.4e-10 40.0 0.1 1.3 1 0 0 1 1 1 1 PH domain EF-hand_5 PF13202.1 KOO33170.1 - 3.9e-05 22.7 0.8 3.9e-05 22.7 0.6 3.4 4 0 0 4 4 4 2 EF hand PDZ PF00595.19 KOO33170.1 - 5.9e-05 23.1 0.0 0.00011 22.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PH_11 PF15413.1 KOO33170.1 - 0.00075 19.7 0.7 0.0014 18.8 0.5 1.5 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.1 KOO33170.1 - 0.0026 17.7 0.0 0.0048 16.9 0.0 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PDZ_2 PF13180.1 KOO33170.1 - 0.028 14.3 0.0 0.084 12.7 0.0 1.8 2 0 0 2 2 2 0 PDZ domain Mcp5_PH PF12814.2 KOO33170.1 - 0.14 12.0 0.1 0.3 11.0 0.0 1.6 2 0 0 2 2 2 0 Meiotic cell cortex C-terminal pleckstrin homology Pectate_lyase_3 PF12708.2 KOO33171.1 - 0.0016 18.6 0.0 0.0022 18.1 0.0 1.2 1 0 0 1 1 1 1 Pectate lyase superfamily protein Guanylate_cyc PF00211.15 KOO33172.1 - 2.7e-20 72.5 0.0 1.7e-11 43.8 0.0 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain cNMP_binding PF00027.24 KOO33172.1 - 3.3e-16 58.8 0.0 6.6e-16 57.9 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain TPR_11 PF13414.1 KOO33172.1 - 0.0093 15.5 2.7 0.018 14.6 0.1 2.8 3 0 0 3 3 3 1 TPR repeat TPR_12 PF13424.1 KOO33172.1 - 0.91 9.5 10.0 4.2 7.3 0.3 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat HATPase_c_3 PF13589.1 KOO33173.1 - 0.0067 16.0 0.0 0.61 9.7 0.0 2.2 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MukE PF04288.8 KOO33173.1 - 0.054 12.2 0.0 0.085 11.6 0.0 1.2 1 0 0 1 1 1 0 MukE-like family HlyIII PF03006.15 KOO33174.1 - 9.9e-12 44.7 9.5 1.2e-11 44.4 6.6 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF1129 PF06570.6 KOO33174.1 - 0.0016 17.7 0.6 0.0024 17.2 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1129) DUF3325 PF11804.3 KOO33174.1 - 0.17 11.8 8.1 1.2 9.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3325) Yip1 PF04893.12 KOO33174.1 - 0.47 9.9 8.0 0.9 9.0 5.5 1.7 1 1 0 1 1 1 0 Yip1 domain Pkinase PF00069.20 KOO33175.1 - 4.9e-36 124.2 0.0 6.8e-36 123.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33175.1 - 1.8e-21 76.3 0.0 5.7e-21 74.7 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO33175.1 - 0.0026 17.5 0.2 0.089 12.5 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO33175.1 - 0.16 10.8 0.0 0.26 10.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like AA_permease_2 PF13520.1 KOO33177.1 - 5.9e-42 143.6 18.4 7.4e-42 143.3 12.7 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KOO33177.1 - 1.2e-28 99.6 14.0 1.7e-28 99.1 9.7 1.1 1 0 0 1 1 1 1 Amino acid permease Mg_trans_NIPA PF05653.9 KOO33178.1 - 6.1e-19 68.0 9.1 5.9e-17 61.5 5.0 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA DUF4131 PF13567.1 KOO33178.1 - 0.014 14.7 10.1 0.077 12.4 1.3 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) SID-1_RNA_chan PF13965.1 KOO33178.1 - 0.24 9.5 3.8 0.97 7.5 0.0 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 FHA PF00498.21 KOO33179.1 - 6.4e-06 26.1 0.0 1.1e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 FHA domain DUF1664 PF07889.7 KOO33180.1 - 0.0085 15.8 1.6 0.028 14.2 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) Serine_rich PF08824.5 KOO33180.1 - 0.038 13.7 0.5 0.069 12.8 0.3 1.5 1 1 0 1 1 1 0 Serine rich protein interaction domain PEP-utilisers_N PF05524.8 KOO33180.1 - 0.077 12.8 3.9 0.047 13.4 0.5 2.3 2 1 1 3 3 3 0 PEP-utilising enzyme, N-terminal LRR_5 PF13306.1 KOO33181.1 - 2e-73 244.1 0.0 4e-39 133.2 0.0 2.9 1 1 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO33181.1 - 2e-22 78.7 0.0 8.4e-05 22.2 0.0 6.2 2 1 4 6 6 6 5 Leucine rich repeat Skp1 PF01466.14 KOO33181.1 - 0.0099 15.8 0.0 0.017 15.1 0.0 1.3 1 0 0 1 1 1 1 Skp1 family, dimerisation domain DUF3938 PF13074.1 KOO33181.1 - 0.55 10.1 3.5 0.53 10.1 0.4 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF3938) Myosin_head PF00063.16 KOO33182.1 - 2.9e-158 527.9 0.0 3e-76 256.9 0.0 4.5 3 1 0 3 3 3 3 Myosin head (motor domain) AAA_22 PF13401.1 KOO33182.1 - 0.0035 17.4 1.3 0.1 12.7 0.0 3.1 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 KOO33182.1 - 0.015 14.3 0.0 0.039 13.0 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin DUF1386 PF07138.6 KOO33182.1 - 0.027 13.5 0.6 0.057 12.5 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1386) Mitoc_L55 PF09776.4 KOO33183.1 - 0.0016 18.0 0.1 32 4.1 0.0 3.9 1 1 3 4 4 4 4 Mitochondrial ribosomal protein L55 LRR_5 PF13306.1 KOO33184.1 - 8.1e-163 533.2 0.1 9.2e-38 128.8 0.0 3.8 1 1 4 5 5 5 5 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO33184.1 - 2.2e-39 133.0 8.1 9.8e-06 25.2 0.0 8.0 2 1 9 11 11 11 10 Leucine rich repeat Skp1 PF01466.14 KOO33184.1 - 0.022 14.8 0.0 0.038 14.0 0.0 1.3 1 0 0 1 1 1 0 Skp1 family, dimerisation domain GATase_7 PF13537.1 KOO33185.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Glutamine amidotransferase domain PUB PF09409.5 KOO33186.1 - 1e-29 102.0 0.1 1.2e-13 50.6 0.0 2.4 2 0 0 2 2 2 2 PUB domain OTU PF02338.14 KOO33186.1 - 5.4e-14 52.8 0.0 1.1e-13 51.7 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease Leptin PF02024.10 KOO33186.1 - 0.00067 19.3 0.0 0.0072 16.0 0.0 2.3 2 0 0 2 2 2 1 Leptin GM_CSF PF01109.12 KOO33187.1 - 0.0034 17.3 0.0 0.17 11.8 0.0 2.2 2 0 0 2 2 2 2 Granulocyte-macrophage colony-stimulating factor PUB PF09409.5 KOO33188.1 - 1.4e-17 63.2 0.1 2.6e-17 62.3 0.1 1.4 1 0 0 1 1 1 1 PUB domain OTU PF02338.14 KOO33188.1 - 5.5e-16 59.2 0.0 1.1e-15 58.2 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease Pkinase PF00069.20 KOO33189.1 - 4.5e-57 193.1 0.0 6.1e-57 192.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33189.1 - 2.2e-28 99.0 0.0 3.1e-28 98.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase LRR_6 PF13516.1 KOO33189.1 - 9.8e-09 34.4 12.5 0.0074 16.2 0.0 5.5 6 0 0 6 6 6 3 Leucine Rich repeat LRR_4 PF12799.2 KOO33189.1 - 4.2e-05 23.0 2.9 0.0034 16.9 0.6 2.7 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO33189.1 - 0.019 15.0 3.2 9.2 6.9 0.0 4.4 4 0 0 4 4 4 0 Leucine rich repeat LRR_8 PF13855.1 KOO33189.1 - 0.023 14.4 2.5 0.057 13.1 1.5 2.0 1 1 0 1 1 1 0 Leucine rich repeat LRR_1 PF00560.28 KOO33189.1 - 0.026 14.5 0.0 2.8 8.2 0.0 3.5 3 0 0 3 3 3 0 Leucine Rich Repeat Kdo PF06293.9 KOO33189.1 - 0.071 12.1 0.1 0.12 11.3 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 KOO33189.1 - 0.097 12.0 0.1 0.19 11.0 0.1 1.4 1 0 0 1 1 1 0 RIO1 family EF-hand_7 PF13499.1 KOO33191.1 - 3.5e-20 71.8 12.0 1.9e-08 34.3 0.9 5.3 3 1 2 5 5 5 5 EF-hand domain pair EF-hand_1 PF00036.27 KOO33191.1 - 1.5e-19 67.7 17.0 5.8e-05 22.1 0.1 6.9 7 0 0 7 7 7 5 EF hand EF-hand_6 PF13405.1 KOO33191.1 - 2.3e-15 55.0 18.2 0.005 16.6 0.2 7.7 7 1 1 8 8 8 5 EF-hand domain EF-hand_8 PF13833.1 KOO33191.1 - 4.3e-12 45.4 15.5 0.00074 19.0 0.6 6.0 5 2 2 7 7 7 5 EF-hand domain pair EF-hand_5 PF13202.1 KOO33191.1 - 4e-05 22.7 20.7 0.025 13.9 0.5 6.1 7 0 0 7 7 7 3 EF hand SPARC_Ca_bdg PF10591.4 KOO33191.1 - 0.19 11.7 2.5 0.68 9.9 0.2 3.0 4 0 0 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO33191.1 - 0.51 10.0 10.0 14 5.4 0.1 4.8 6 0 0 6 6 6 0 EF hand CDP-OH_P_transf PF01066.16 KOO33192.1 - 4.3e-11 43.0 1.4 4.3e-11 43.0 1.0 2.2 2 2 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Glyco_hydro_2_N PF02837.13 KOO33193.1 - 5e-06 26.1 0.0 1e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain PAN_1 PF00024.21 KOO33193.1 - 5.9e-05 22.7 0.3 0.00014 21.5 0.2 1.6 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.1 KOO33193.1 - 0.00024 20.7 3.3 0.00065 19.3 2.3 1.8 1 0 0 1 1 1 1 PAN domain Glyco_hydro_2_C PF02836.12 KOO33193.1 - 0.0017 17.3 0.0 0.0029 16.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Methyltransf_18 PF12847.2 KOO33194.1 - 1.4e-07 32.0 0.0 2.7e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO33194.1 - 8.5e-07 28.6 0.0 1.4e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 KOO33194.1 - 2.7e-06 26.5 0.0 1.3e-05 24.3 0.0 2.0 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.1 KOO33194.1 - 9.2e-06 25.9 0.0 2.4e-05 24.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO33194.1 - 3.2e-05 24.3 0.0 5.8e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO33194.1 - 0.00026 21.3 0.0 0.00048 20.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOO33194.1 - 0.00095 18.5 0.0 0.0016 17.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 KOO33194.1 - 0.0011 18.9 3.1 0.003 17.5 2.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Toprim_N PF08275.6 KOO33195.1 - 4.2e-27 94.6 0.0 7.1e-27 93.8 0.0 1.3 1 0 0 1 1 1 1 DNA primase catalytic core, N-terminal domain zf-CHC2 PF01807.15 KOO33195.1 - 1.5e-21 75.7 0.0 2.5e-21 75.0 0.0 1.3 1 0 0 1 1 1 1 CHC2 zinc finger Toprim_4 PF13662.1 KOO33195.1 - 1.3e-15 57.1 0.1 4.2e-15 55.5 0.1 2.0 1 0 0 1 1 1 1 Toprim domain Toprim_2 PF13155.1 KOO33195.1 - 1.7e-11 44.2 0.0 3.4e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 Toprim-like Toprim_3 PF13362.1 KOO33195.1 - 5.8e-08 32.8 1.1 1.7e-07 31.3 0.0 2.4 2 1 0 2 2 2 1 Toprim domain Toprim PF01751.17 KOO33195.1 - 1.2e-05 25.2 0.1 4.9e-05 23.2 0.0 2.2 2 0 0 2 2 2 1 Toprim domain AAA PF00004.24 KOO33196.1 - 6.2e-89 294.9 0.0 1.3e-43 148.3 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 KOO33196.1 - 1.5e-15 56.8 0.0 6e-08 32.0 0.0 3.5 3 1 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 KOO33196.1 - 3.4e-13 49.8 0.0 1.5e-06 28.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 KOO33196.1 - 1.6e-12 47.3 0.1 2.1e-06 27.5 0.0 3.6 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOO33196.1 - 5.3e-12 46.0 1.2 0.00017 21.6 0.0 3.7 3 2 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.1 KOO33196.1 - 2.6e-11 43.7 1.0 0.003 17.6 0.0 4.3 3 2 0 3 3 2 2 AAA domain AAA_17 PF13207.1 KOO33196.1 - 1.6e-10 41.8 0.0 0.0002 22.1 0.0 2.9 3 0 0 3 3 2 2 AAA domain Zeta_toxin PF06414.7 KOO33196.1 - 8.5e-10 38.0 0.3 0.00017 20.7 0.0 2.8 3 0 0 3 3 3 2 Zeta toxin AAA_14 PF13173.1 KOO33196.1 - 2e-09 37.3 0.0 0.0011 18.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.8 KOO33196.1 - 2.7e-09 36.2 0.0 0.00043 19.1 0.0 2.2 2 0 0 2 2 2 2 TIP49 C-terminus AAA_33 PF13671.1 KOO33196.1 - 1.4e-08 34.6 0.0 0.0011 18.8 0.0 3.0 3 0 0 3 3 2 2 AAA domain Sigma54_activ_2 PF14532.1 KOO33196.1 - 1.6e-08 34.7 0.0 0.0072 16.3 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_25 PF13481.1 KOO33196.1 - 3.7e-07 29.7 0.7 0.41 10.0 0.0 3.6 2 1 0 3 3 3 3 AAA domain RNA_helicase PF00910.17 KOO33196.1 - 4.3e-07 30.0 0.0 0.0041 17.2 0.0 3.2 3 0 0 3 3 3 2 RNA helicase ABC_tran PF00005.22 KOO33196.1 - 7.8e-07 29.4 0.0 0.0042 17.3 0.0 2.7 2 1 0 2 2 2 2 ABC transporter Mg_chelatase PF01078.16 KOO33196.1 - 1.1e-06 27.9 0.1 0.0083 15.3 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.1 KOO33196.1 - 1.5e-06 28.5 0.0 0.033 14.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 KOO33196.1 - 2.5e-06 27.0 0.0 0.029 13.7 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein Sigma54_activat PF00158.21 KOO33196.1 - 2.8e-06 26.8 0.1 0.061 12.8 0.0 3.6 3 1 0 3 3 3 2 Sigma-54 interaction domain NACHT PF05729.7 KOO33196.1 - 6.3e-06 25.9 0.2 0.32 10.6 0.0 3.4 3 1 0 3 3 3 2 NACHT domain AAA_28 PF13521.1 KOO33196.1 - 2.2e-05 24.4 0.0 0.046 13.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain CDC48_N PF02359.13 KOO33196.1 - 3.5e-05 23.6 0.1 0.00014 21.7 0.1 2.0 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain KaiC PF06745.8 KOO33196.1 - 8.5e-05 21.7 0.3 5.5 6.0 0.0 3.3 2 1 0 3 3 3 0 KaiC NB-ARC PF00931.17 KOO33196.1 - 0.00011 21.1 0.1 0.067 12.0 0.0 2.2 2 0 0 2 2 2 2 NB-ARC domain AAA_19 PF13245.1 KOO33196.1 - 0.00013 21.6 8.0 0.053 13.2 0.2 3.7 3 1 0 3 3 2 2 Part of AAA domain Arch_ATPase PF01637.13 KOO33196.1 - 0.00066 19.4 0.1 0.086 12.5 0.0 3.2 2 2 2 4 4 3 1 Archaeal ATPase UPF0079 PF02367.12 KOO33196.1 - 0.00075 19.1 0.1 0.63 9.6 0.0 2.5 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 Bac_DnaA PF00308.13 KOO33196.1 - 0.001 18.7 0.0 0.21 11.2 0.0 2.6 3 0 0 3 3 2 1 Bacterial dnaA protein Molydop_binding PF01568.16 KOO33196.1 - 0.001 18.8 0.2 0.0023 17.7 0.1 1.5 1 0 0 1 1 1 1 Molydopterin dinucleotide binding domain AAA_24 PF13479.1 KOO33196.1 - 0.0012 18.4 0.2 0.69 9.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.10 KOO33196.1 - 0.0015 17.3 0.0 0.11 11.1 0.0 2.1 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein DUF815 PF05673.8 KOO33196.1 - 0.0022 16.9 0.0 0.1 11.5 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Cytidylate_kin2 PF13189.1 KOO33196.1 - 0.0023 17.8 0.0 1.1 9.1 0.0 2.3 2 0 0 2 2 2 1 Cytidylate kinase-like family AAA_29 PF13555.1 KOO33196.1 - 0.0024 17.3 0.0 2.6 7.6 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_3 PF07726.6 KOO33196.1 - 0.0028 17.2 0.0 2.3 7.8 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.13 KOO33196.1 - 0.0072 15.8 0.0 0.16 11.4 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase PhoH PF02562.11 KOO33196.1 - 0.011 14.9 0.1 1.1 8.4 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein ResIII PF04851.10 KOO33196.1 - 0.016 15.0 0.0 6.1 6.6 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Vps4_C PF09336.5 KOO33196.1 - 0.016 15.0 0.3 0.1 12.5 0.1 2.5 3 0 0 3 3 1 0 Vps4 C terminal oligomerisation domain PduV-EutP PF10662.4 KOO33196.1 - 0.019 14.4 0.0 3.1 7.2 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.1 KOO33196.1 - 0.019 15.2 0.0 6 7.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain T2SE PF00437.15 KOO33196.1 - 0.023 13.5 0.0 1.9 7.3 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein SKI PF01202.17 KOO33196.1 - 0.039 13.8 0.0 1.3 8.8 0.0 2.4 2 0 0 2 2 2 0 Shikimate kinase DEAD PF00270.24 KOO33196.1 - 0.044 13.2 0.1 25 4.3 0.0 3.5 3 1 0 3 3 3 0 DEAD/DEAH box helicase AAA_10 PF12846.2 KOO33196.1 - 0.071 12.5 1.6 9.8 5.5 0.1 3.2 3 0 0 3 3 3 0 AAA-like domain Parvo_NS1 PF01057.12 KOO33196.1 - 0.073 11.9 0.0 0.87 8.3 0.0 2.1 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AFG1_ATPase PF03969.11 KOO33196.1 - 0.075 11.8 0.1 11 4.7 0.0 2.2 2 0 0 2 2 2 0 AFG1-like ATPase APS_kinase PF01583.15 KOO33196.1 - 0.084 12.5 0.0 17 4.9 0.0 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase DUF2075 PF09848.4 KOO33196.1 - 0.11 11.4 0.0 12 4.7 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) SRPRB PF09439.5 KOO33196.1 - 0.12 11.5 0.0 11 5.1 0.0 2.3 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit ATP-synt_ab PF00006.20 KOO33196.1 - 0.13 11.7 0.0 0.56 9.6 0.0 2.0 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain NTPase_1 PF03266.10 KOO33196.1 - 0.14 11.8 5.7 3.2 7.4 0.0 3.5 3 1 1 4 4 3 0 NTPase SMC_N PF02463.14 KOO33196.1 - 0.28 10.3 0.3 26 3.9 0.0 2.9 2 1 1 3 3 3 0 RecF/RecN/SMC N terminal domain DUF2921 PF11145.3 KOO33196.1 - 0.38 8.4 0.0 0.52 7.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2921) AAA_21 PF13304.1 KOO33196.1 - 0.66 9.8 1.3 8 6.3 0.0 2.9 3 1 1 4 4 3 0 AAA domain Exo_endo_phos PF03372.18 KOO33197.1 - 9.2e-09 35.5 0.0 9.4e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Hint PF01079.15 KOO33198.1 - 1.1e-16 60.7 0.3 1.3e-16 60.4 0.2 1.0 1 0 0 1 1 1 1 Hint module LCCL PF03815.14 KOO33198.1 - 0.14 12.1 0.1 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 LCCL domain Gly-zipper_OmpA PF13436.1 KOO33199.1 - 3 7.5 11.3 6.1 6.5 7.8 1.5 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain Patatin PF01734.17 KOO33200.1 - 6.4e-21 75.2 0.0 1.6e-20 73.8 0.0 1.7 1 0 0 1 1 1 1 Patatin-like phospholipase DUF3336 PF11815.3 KOO33200.1 - 2.1e-20 72.6 0.0 4.7e-20 71.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Chorein_N PF12624.2 KOO33201.1 - 6.6e-07 28.8 0.0 2e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter Rod_cone_degen PF15201.1 KOO33202.1 - 0.0064 16.3 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 Progressive rod-cone degeneration Nucleoplasmin PF03066.10 KOO33203.1 - 0.45 10.0 7.0 0.68 9.4 4.9 1.4 1 0 0 1 1 1 0 Nucleoplasmin CENP-B_dimeris PF09026.5 KOO33203.1 - 0.59 10.4 11.0 0.057 13.6 3.8 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.8 KOO33203.1 - 1.3 6.7 7.2 1.7 6.3 5.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi Sigma70_ner PF04546.8 KOO33203.1 - 1.6 8.2 9.7 3.4 7.2 6.7 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region Bestrophin PF01062.16 KOO33205.1 - 6.7e-35 120.4 1.0 8.9e-35 120.0 0.7 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel NARP1 PF12569.3 KOO33206.1 - 0.51 9.0 3.0 0.77 8.4 2.1 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 LRR_5 PF13306.1 KOO33208.1 - 2.3e-115 379.8 6.3 8.6e-43 145.1 0.1 3.9 1 1 1 3 3 3 3 Leucine rich repeats (6 copies) NB-ARC PF00931.17 KOO33208.1 - 2.7e-25 88.7 0.0 5e-25 87.9 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain LRR_8 PF13855.1 KOO33208.1 - 1.7e-12 46.9 0.0 0.027 14.2 0.0 6.5 1 1 5 8 8 8 5 Leucine rich repeat CHAT PF12770.2 KOO33208.1 - 9.1e-11 41.4 1.5 1.4e-10 40.7 1.0 1.3 1 0 0 1 1 1 1 CHAT domain AAA_22 PF13401.1 KOO33208.1 - 0.011 15.8 0.0 0.028 14.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 KOO33208.1 - 0.033 13.8 0.1 0.059 13.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain LRR_5 PF13306.1 KOO33209.1 - 1.2e-39 135.0 0.5 2.5e-39 133.9 0.3 1.5 1 1 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO33209.1 - 2e-06 27.4 0.0 0.13 11.9 0.0 3.4 1 1 3 4 4 4 4 Leucine rich repeat MitoNEET_N PF10660.4 KOO33209.1 - 0.02 14.7 0.1 8.3 6.3 0.0 3.3 1 1 2 3 3 3 0 Iron-containing outer mitochondrial membrane protein N-terminus Colicin_C PF12106.3 KOO33209.1 - 0.037 13.6 18.2 2.7 7.6 0.4 4.3 4 0 0 4 4 4 0 Colicin C terminal ribonuclease domain A2M PF00207.17 KOO33209.1 - 0.05 13.1 1.6 12 5.5 0.0 3.3 2 1 1 3 3 3 0 Alpha-2-macroglobulin family TFIID_30kDa PF03540.8 KOO33209.1 - 0.63 9.9 3.7 82 3.1 0.0 3.6 4 0 0 4 4 4 0 Transcription initiation factor TFIID 23-30kDa subunit DUF1068 PF06364.7 KOO33209.1 - 0.82 9.2 11.9 0.38 10.3 1.1 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1068) ZF-HD_dimer PF04770.7 KOO33209.1 - 9.5 6.3 7.4 4.3 7.4 2.1 2.5 4 0 0 4 4 4 0 ZF-HD protein dimerisation region PIF1 PF05970.9 KOO33210.1 - 1.8e-13 50.2 0.1 2.8e-13 49.5 0.1 1.2 1 0 0 1 1 1 1 PIF1-like helicase SAP PF02037.22 KOO33210.1 - 2.8e-07 29.8 1.7 8.9e-07 28.2 1.2 1.9 1 0 0 1 1 1 1 SAP domain AAA_30 PF13604.1 KOO33210.1 - 0.00033 20.2 2.8 0.0004 20.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 KOO33210.1 - 0.0013 18.4 0.0 0.056 13.1 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF3049 PF11250.3 KOO33210.1 - 0.0054 16.4 0.1 0.52 10.1 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3049) Helicase_RecD PF05127.9 KOO33210.1 - 0.046 13.3 0.0 0.38 10.3 0.0 2.1 2 0 0 2 2 2 0 Helicase DUF258 PF03193.11 KOO33210.1 - 0.09 11.9 0.1 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 KOO33210.1 - 0.1 12.7 0.0 0.27 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 KOO33210.1 - 0.19 11.4 0.2 0.37 10.5 0.1 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Apolipoprotein PF01442.13 KOO33210.1 - 0.46 9.9 5.7 0.088 12.3 0.3 2.0 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Ank_2 PF12796.2 KOO33211.1 - 2.6e-30 104.5 1.2 4.5e-16 58.9 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO33211.1 - 3.3e-19 68.8 4.2 2.3e-08 34.3 0.0 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO33211.1 - 6.2e-17 60.4 1.1 9.5e-07 28.3 0.1 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 KOO33211.1 - 8e-13 48.1 1.5 4.3e-10 39.5 0.5 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO33211.1 - 8.4e-08 31.7 0.2 0.0055 16.8 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeat DUF4475 PF14753.1 KOO33212.1 - 1.9e-19 69.9 20.8 3e-19 69.2 14.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4475) DnaJ PF00226.26 KOO33212.1 - 1.2e-11 44.1 0.0 2.2e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain TIR_2 PF13676.1 KOO33213.1 - 5.1e-06 26.5 0.0 1.1e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 TIR domain DDT PF02791.12 KOO33214.1 - 1.3e-11 44.0 0.2 2.9e-11 42.9 0.1 1.5 1 0 0 1 1 1 1 DDT domain MBD PF01429.14 KOO33214.1 - 9.4e-05 21.8 0.0 0.0002 20.8 0.0 1.4 1 0 0 1 1 1 1 Methyl-CpG binding domain HMG_box_2 PF09011.5 KOO33214.1 - 0.0004 20.6 6.6 0.35 11.2 0.7 3.8 3 0 0 3 3 3 2 HMG-box domain HMG_box PF00505.14 KOO33214.1 - 0.048 13.9 11.4 0.07 13.4 0.8 4.2 3 1 0 3 3 3 0 HMG (high mobility group) box Pkinase PF00069.20 KOO33215.1 - 3.3e-36 124.7 0.0 4.8e-36 124.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33215.1 - 8.1e-32 110.3 0.0 1.1e-31 109.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase TIR_2 PF13676.1 KOO33215.1 - 2e-05 24.6 0.0 7.1e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 TIR domain Kinase-like PF14531.1 KOO33215.1 - 7.6e-05 21.8 0.0 0.00013 21.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO33215.1 - 8e-05 22.4 0.4 0.017 14.8 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 KOO33215.1 - 0.046 12.7 0.1 0.075 12.0 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Cellulase-like PF12876.2 KOO33215.1 - 0.062 13.7 0.0 0.17 12.3 0.0 1.7 1 0 0 1 1 1 0 Sugar-binding cellulase-like NIF PF03031.13 KOO33216.1 - 1.1e-24 86.9 0.0 2.9e-24 85.5 0.0 1.7 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase YGGT PF02325.12 KOO33217.1 - 1.3e-18 66.7 2.5 1.8e-18 66.2 1.7 1.2 1 0 0 1 1 1 1 YGGT family EF-hand_7 PF13499.1 KOO33219.1 - 1.4e-05 25.1 0.0 3.3e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO33219.1 - 0.00015 20.8 0.2 0.00083 18.4 0.0 2.3 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO33219.1 - 0.0041 16.8 0.0 0.015 15.1 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.1 KOO33219.1 - 0.007 15.9 0.6 0.097 12.3 0.0 2.8 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO33219.1 - 0.01 15.1 0.0 0.029 13.7 0.0 1.8 1 0 0 1 1 1 0 EF hand Slx4 PF09494.5 KOO33219.1 - 0.14 11.8 0.1 0.65 9.7 0.0 2.0 2 0 0 2 2 2 0 Slx4 endonuclease SPRY PF00622.23 KOO33220.1 - 3.5e-22 78.7 0.0 4.6e-22 78.4 0.0 1.2 1 0 0 1 1 1 1 SPRY domain Ank_2 PF12796.2 KOO33223.1 - 2.7e-70 232.7 20.2 1.6e-18 66.7 1.3 4.6 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.25 KOO33223.1 - 4.6e-49 161.8 15.3 3.4e-09 36.0 0.2 7.4 7 0 0 7 7 7 7 Ankyrin repeat Ank_4 PF13637.1 KOO33223.1 - 7.7e-41 137.7 0.6 8.8e-09 35.6 0.1 5.4 4 1 1 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO33223.1 - 3.5e-38 125.8 4.0 2.3e-06 27.2 0.1 7.5 7 0 0 7 7 7 7 Ankyrin repeat Ank_5 PF13857.1 KOO33223.1 - 5.1e-36 121.8 12.0 3.1e-06 27.2 0.3 7.1 1 1 6 7 7 7 7 Ankyrin repeats (many copies) Shigella_OspC PF06128.6 KOO33223.1 - 0.0064 16.0 0.0 0.056 12.9 0.0 2.3 3 0 0 3 3 3 1 Shigella flexneri OspC protein Pyridoxal_deC PF00282.14 KOO33223.1 - 0.12 10.7 0.7 0.16 10.3 0.5 1.1 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain TRAM_LAG1_CLN8 PF03798.11 KOO33224.1 - 5.3e-12 45.6 14.6 6.2e-12 45.4 10.1 1.0 1 0 0 1 1 1 1 TLC domain UPF0182 PF03699.8 KOO33224.1 - 0.12 10.3 0.4 0.15 9.9 0.3 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) CLP_protease PF00574.18 KOO33225.1 - 2.1e-74 249.1 0.0 2.5e-74 248.8 0.0 1.0 1 0 0 1 1 1 1 Clp protease DNA_ligase_A_M PF01068.16 KOO33227.1 - 1.4e-57 194.3 0.0 2.4e-57 193.5 0.0 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 KOO33227.1 - 2.6e-45 154.3 0.2 4.1e-45 153.7 0.1 1.3 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 KOO33227.1 - 3e-25 88.4 0.0 8.5e-25 87.0 0.0 1.8 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DNA_ligase_OB_2 PF14743.1 KOO33227.1 - 0.013 15.1 1.4 1.7 8.3 0.0 2.6 2 0 0 2 2 2 0 DNA ligase OB-like domain PDZ PF00595.19 KOO33228.1 - 5.9e-08 32.7 0.7 0.0014 18.7 0.0 2.3 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO33228.1 - 2.9e-07 30.2 0.1 0.0041 16.9 0.0 2.4 2 0 0 2 2 2 2 PDZ domain C2 PF00168.25 KOO33228.1 - 2.6e-05 23.9 0.0 6.5e-05 22.6 0.0 1.7 2 0 0 2 2 2 1 C2 domain Tricorn_PDZ PF14685.1 KOO33228.1 - 4.7e-05 23.1 0.7 0.0028 17.4 0.0 2.3 2 0 0 2 2 2 1 Tricorn protease PDZ domain PIH1 PF08190.7 KOO33230.1 - 5.8e-14 52.2 0.0 9.9e-14 51.5 0.0 1.4 2 0 0 2 2 2 1 pre-RNA processing PIH1/Nop17 CS PF04969.11 KOO33230.1 - 3.9e-07 30.5 0.0 0.0003 21.2 0.0 2.1 1 1 1 2 2 2 2 CS domain 2OG-FeII_Oxy_2 PF13532.1 KOO33231.1 - 0.0024 17.7 0.0 0.0039 17.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily E1_dh PF00676.15 KOO33232.1 - 2.1e-103 345.1 0.1 2.7e-103 344.8 0.1 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.1 KOO33232.1 - 0.00037 19.5 0.0 0.00057 18.9 0.0 1.2 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase E3_binding PF02817.12 KOO33232.1 - 0.0034 16.9 0.0 0.0078 15.8 0.0 1.6 1 0 0 1 1 1 1 e3 binding domain Transketolase_N PF00456.16 KOO33232.1 - 0.098 11.4 0.0 0.098 11.4 0.0 2.0 4 0 0 4 4 4 0 Transketolase, thiamine diphosphate binding domain DCD PF06559.6 KOO33232.1 - 0.11 10.8 0.0 0.2 10.0 0.0 1.4 1 0 0 1 1 1 0 2'-deoxycytidine 5'-triphosphate deaminase (DCD) Pkinase PF00069.20 KOO33233.1 - 2e-59 200.8 0.0 2.5e-59 200.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33233.1 - 1.1e-41 142.6 0.0 1.3e-41 142.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO33233.1 - 1.6e-05 24.0 0.0 6e-05 22.1 0.0 1.8 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.9 KOO33233.1 - 7e-05 21.9 0.1 0.00011 21.4 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO33233.1 - 0.034 13.8 0.0 0.057 13.1 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ank_2 PF12796.2 KOO33234.1 - 1.3e-05 25.4 0.0 0.02 15.2 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO33234.1 - 0.0044 17.4 0.7 3.1 8.4 0.0 3.8 2 2 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO33234.1 - 0.015 15.5 2.5 34 4.8 0.0 4.1 3 1 1 4 4 4 0 Ankyrin repeats (many copies) CBM_1 PF00734.13 KOO33238.1 - 1.7e-18 65.9 71.6 4.6e-08 32.5 6.4 6.8 4 3 0 4 4 4 4 Fungal cellulose binding domain FtsZ_C PF12327.3 KOO33240.1 - 0.1 12.6 2.9 0.15 12.1 1.9 1.5 1 1 0 1 1 1 0 FtsZ family, C-terminal domain Pkinase PF00069.20 KOO33241.1 - 6.9e-25 87.6 0.0 1e-24 87.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33241.1 - 2.6e-23 82.4 0.1 3.9e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.2 KOO33241.1 - 8.1e-10 38.9 0.1 3.3e-09 36.9 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO33241.1 - 1.8e-06 28.2 0.1 0.0071 16.8 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO33241.1 - 5.4e-06 26.4 0.3 2.8e-05 24.2 0.0 2.4 1 1 1 2 2 2 1 Ankyrin repeats (many copies) tRNA_U5-meth_tr PF05958.6 KOO33241.1 - 5.9e-05 21.9 0.0 0.00012 20.9 0.0 1.5 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Ank_3 PF13606.1 KOO33241.1 - 0.002 18.1 0.8 0.4 11.0 0.0 3.3 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.25 KOO33241.1 - 0.0049 16.6 1.7 19 5.2 0.1 4.6 5 0 0 5 5 5 0 Ankyrin repeat IQ PF00612.22 KOO33243.1 - 0.22 11.2 14.7 1.3 8.8 1.2 3.8 3 0 0 3 3 3 0 IQ calmodulin-binding motif Ank_2 PF12796.2 KOO33244.1 - 6.8e-08 32.7 0.0 2.5e-07 30.9 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO33244.1 - 7e-08 31.9 0.0 3.8e-07 29.5 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.1 KOO33244.1 - 1.7e-06 28.3 0.0 3.9e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO33244.1 - 4.1e-05 23.4 0.0 0.00088 19.3 0.0 3.0 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.1 KOO33244.1 - 0.00034 20.7 0.0 0.0014 18.7 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) IQ PF00612.22 KOO33244.1 - 0.00075 18.9 2.4 0.0025 17.2 1.6 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif DUF1434 PF07254.7 KOO33244.1 - 0.3 10.8 0.0 0.57 10.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1434) EF-hand_1 PF00036.27 KOO33245.1 - 1e-19 68.2 2.4 0.00012 21.1 0.0 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 KOO33245.1 - 7.1e-19 65.9 5.5 3.2e-05 23.4 0.1 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.1 KOO33245.1 - 5.5e-18 64.8 0.1 1.7e-10 40.8 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO33245.1 - 1.2e-17 63.2 2.0 1.2e-06 28.0 0.1 3.6 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO33245.1 - 1.2e-16 59.1 8.2 2.2e-05 23.5 0.0 4.0 4 0 0 4 4 4 3 EF hand SPARC_Ca_bdg PF10591.4 KOO33245.1 - 0.042 13.8 0.0 0.79 9.7 0.0 2.8 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region APOBEC_N PF08210.6 KOO33246.1 - 1e-20 74.1 4.1 4.9e-19 68.6 0.0 2.8 2 1 0 2 2 2 2 APOBEC-like N-terminal domain zf-CCCH PF00642.19 KOO33247.1 - 8.3e-24 82.7 18.9 2.8e-09 36.4 0.3 3.4 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 KOO33247.1 - 0.89 9.6 14.1 0.97 9.5 0.1 3.6 3 1 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type Ion_trans PF00520.26 KOO33250.1 - 2.1e-12 46.7 13.6 3.8e-12 45.8 9.4 1.4 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO33250.1 - 5e-12 45.3 4.7 5e-12 45.3 3.2 2.3 2 1 0 2 2 2 1 Ion channel cNMP_binding PF00027.24 KOO33250.1 - 1.6e-08 34.2 0.0 3.2e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_N PF08412.5 KOO33250.1 - 0.00015 21.0 0.9 0.00039 19.6 0.0 2.1 2 0 0 2 2 2 1 Ion transport protein N-terminal Histone PF00125.19 KOO33252.1 - 5.3e-06 26.4 0.6 7.5e-06 25.9 0.4 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 KOO33252.1 - 0.0029 17.7 0.1 0.0042 17.2 0.1 1.3 1 0 0 1 1 1 1 Kinetochore component CENP-S Bromo_TP PF07524.8 KOO33252.1 - 0.064 12.9 0.1 0.1 12.3 0.1 1.3 1 0 0 1 1 1 0 Bromodomain associated Bromodomain PF00439.20 KOO33254.1 - 6.7e-16 57.9 0.0 1.5e-15 56.8 0.0 1.6 1 0 0 1 1 1 1 Bromodomain PHD PF00628.24 KOO33254.1 - 3.3e-07 29.9 11.1 7.5e-07 28.7 7.7 1.7 1 0 0 1 1 1 1 PHD-finger Acetyltransf_7 PF13508.1 KOO33254.1 - 3.3e-07 30.3 0.0 6.9e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 KOO33254.1 - 5.6e-07 29.5 0.1 1.6e-06 28.0 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 KOO33254.1 - 3.3e-05 23.9 2.3 0.00016 21.7 0.0 2.9 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain DUF3749 PF12568.3 KOO33254.1 - 0.052 13.1 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF1336 PF07059.7 KOO33256.1 - 1.6e-17 63.6 0.0 1.7e-17 63.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1336) Exo_endo_phos PF03372.18 KOO33257.1 - 7.9e-09 35.8 0.1 1.1e-08 35.3 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 KOO33257.1 - 0.094 12.3 0.0 0.58 9.7 0.0 2.0 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase IF3_C PF00707.17 KOO33260.1 - 7.1e-29 99.3 0.2 1.1e-28 98.8 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.11 KOO33260.1 - 4.4e-20 71.3 0.2 9.3e-20 70.3 0.2 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain mIF3 PF14877.1 KOO33260.1 - 0.0076 15.6 0.6 0.011 15.0 0.4 1.2 1 0 0 1 1 1 1 Mitochondrial translation initiation factor PSP1 PF04468.7 KOO33260.1 - 0.13 12.2 0.2 0.21 11.5 0.1 1.3 1 0 0 1 1 1 0 PSP1 C-terminal conserved region Exo_endo_phos PF03372.18 KOO33261.1 - 7.9e-09 35.8 0.1 1.1e-08 35.3 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 KOO33261.1 - 0.094 12.3 0.0 0.58 9.7 0.0 2.0 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase DUF4203 PF13886.1 KOO33262.1 - 1.5e-07 31.0 22.4 4.7e-05 22.9 12.8 2.0 2 0 0 2 2 2 2 Domain of unknown function (DUF4203) DUF3040 PF11239.3 KOO33262.1 - 0.02 14.9 2.0 0.02 14.9 1.4 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF3040) DUF4131 PF13567.1 KOO33262.1 - 0.034 13.5 7.6 0.14 11.5 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF2480 PF10652.4 KOO33262.1 - 0.16 11.5 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2480) DUF2749 PF10907.3 KOO33262.1 - 0.67 9.8 0.1 0.67 9.8 0.0 2.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2749) Spore_YtrH PF14034.1 KOO33262.1 - 1.4 8.8 9.2 0.35 10.8 1.8 2.9 2 1 1 3 3 3 0 Sporulation protein YtrH DUF2583 PF10762.4 KOO33262.1 - 2.4 8.3 4.8 4.7 7.4 2.2 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2583) IF3_C PF00707.17 KOO33263.1 - 7.1e-29 99.3 0.2 1.1e-28 98.8 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.11 KOO33263.1 - 4.4e-20 71.3 0.2 9.3e-20 70.3 0.2 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain mIF3 PF14877.1 KOO33263.1 - 0.0076 15.6 0.6 0.011 15.0 0.4 1.2 1 0 0 1 1 1 1 Mitochondrial translation initiation factor PSP1 PF04468.7 KOO33263.1 - 0.13 12.2 0.2 0.21 11.5 0.1 1.3 1 0 0 1 1 1 0 PSP1 C-terminal conserved region PHO4 PF01384.15 KOO33264.1 - 2.6e-48 164.3 0.2 2.8e-48 164.2 0.1 1.1 1 0 0 1 1 1 1 Phosphate transporter family SopA PF13981.1 KOO33264.1 - 0.087 12.8 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 SopA-like central domain Ank_5 PF13857.1 KOO33265.1 - 0.0025 18.0 0.0 0.004 17.3 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (many copies) TIG PF01833.19 KOO33266.1 - 5.2e-58 193.0 9.2 4.7e-06 26.4 0.0 15.6 15 2 0 15 15 15 11 IPT/TIG domain Anth_Ig PF05587.8 KOO33266.1 - 0.0058 16.4 1.9 20 5.1 0.0 5.4 6 0 0 6 6 6 2 Anthrax receptor extracellular domain Pkinase PF00069.20 KOO33267.1 - 2.3e-62 210.5 0.0 3.6e-62 209.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33267.1 - 7.6e-42 143.1 0.0 1.3e-41 142.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Sec5 PF15469.1 KOO33267.1 - 2.3e-07 30.6 0.7 4.6e-05 23.2 0.2 3.0 3 0 0 3 3 3 1 Exocyst complex component Sec5 Kinase-like PF14531.1 KOO33267.1 - 0.00015 20.7 0.0 0.0053 15.7 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Vps51 PF08700.6 KOO33267.1 - 0.00045 19.9 0.7 0.012 15.4 0.0 3.0 3 0 0 3 3 3 1 Vps51/Vps67 Seadorna_VP7 PF07387.6 KOO33267.1 - 0.035 12.9 0.1 0.062 12.1 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 LMBR1 PF04791.11 KOO33268.1 - 1.5e-09 36.9 11.8 2.1e-09 36.5 8.2 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein CitMHS PF03600.11 KOO33269.1 - 4.1e-23 81.5 0.0 8.3e-13 47.6 0.0 2.6 1 1 2 3 3 3 2 Citrate transporter Na_sulph_symp PF00939.14 KOO33269.1 - 4.3e-06 25.8 30.7 2.8e-05 23.1 9.4 2.5 3 0 0 3 3 3 2 Sodium:sulfate symporter transmembrane region TrkA_C PF02080.16 KOO33269.1 - 0.00016 21.1 0.0 0.28 10.7 0.0 2.6 2 0 0 2 2 2 2 TrkA-C domain DnaJ PF00226.26 KOO33271.1 - 2e-28 97.9 1.9 3.1e-28 97.2 1.3 1.3 1 0 0 1 1 1 1 DnaJ domain PDZ PF00595.19 KOO33271.1 - 6.4e-17 61.5 2.3 8.9e-11 41.8 0.1 2.5 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO33271.1 - 1.1e-09 38.0 1.0 0.00012 21.9 0.1 2.3 2 0 0 2 2 2 2 PDZ domain RPT PF13446.1 KOO33271.1 - 0.11 11.8 0.0 0.27 10.6 0.0 1.5 1 0 0 1 1 1 0 A repeated domain in UCH-protein Rad60-SLD PF11976.3 KOO33272.1 - 2.1e-26 91.4 0.1 2.5e-26 91.1 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 KOO33272.1 - 3.9e-12 45.3 0.0 4.8e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family DUF917 PF06032.7 KOO33272.1 - 0.036 12.6 0.0 0.044 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF917) Glucodextran_B PF09136.5 KOO33273.1 - 0.075 13.2 0.3 0.075 13.2 0.2 1.9 2 0 0 2 2 2 0 Glucodextranase, domain B DUF2433 PF10360.4 KOO33273.1 - 0.077 13.3 0.1 0.41 10.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2433) HECT PF00632.20 KOO33274.1 - 2.9e-27 95.6 0.0 4.6e-27 95.0 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) RRM_1 PF00076.17 KOO33274.1 - 1.4e-07 31.0 0.0 2.7e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO33274.1 - 4.2e-06 26.4 0.0 8.4e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO33274.1 - 1.8e-05 24.5 0.0 6.8e-05 22.7 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DUF1618 PF07762.9 KOO33274.1 - 0.012 15.7 0.1 0.06 13.5 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1618) DLH PF01738.13 KOO33275.1 - 1.5e-15 57.1 0.0 2.3e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Gly_transf_sug PF04488.10 KOO33275.1 - 5.4e-10 39.5 0.0 9.2e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Abhydrolase_5 PF12695.2 KOO33275.1 - 1e-08 35.0 0.0 1.6e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family TcdA_TcdB PF12919.2 KOO33275.1 - 0.00059 18.4 0.1 0.67 8.3 0.0 2.1 2 0 0 2 2 2 2 TcdA/TcdB catalytic glycosyltransferase domain Abhydrolase_6 PF12697.2 KOO33275.1 - 0.013 15.3 0.5 0.048 13.5 0.1 2.1 2 1 0 2 2 2 0 Alpha/beta hydrolase family BRK PF07533.11 KOO33275.1 - 0.13 11.7 0.2 0.54 9.7 0.0 2.0 2 0 0 2 2 2 0 BRK domain SAM_1 PF00536.25 KOO33278.1 - 9e-16 57.8 0.6 1e-15 57.6 0.4 1.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.12 KOO33278.1 - 4.8e-13 48.7 0.3 5.3e-13 48.6 0.2 1.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.11 KOO33278.1 - 0.0012 18.5 0.0 0.0015 18.2 0.0 1.2 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain NatB_MDM20 PF09797.4 KOO33279.1 - 3.8e-28 98.2 0.0 6.6e-28 97.4 0.0 1.4 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_16 PF13432.1 KOO33279.1 - 0.00026 21.5 9.6 0.0021 18.6 2.6 6.1 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO33279.1 - 0.019 14.7 4.0 0.019 14.7 2.7 4.6 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.1 KOO33279.1 - 0.079 13.1 4.2 19 5.7 0.3 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat NARP1 PF12569.3 KOO33279.1 - 0.089 11.5 5.9 0.029 13.1 0.6 2.2 2 1 1 3 3 3 0 NMDA receptor-regulated protein 1 Flavodoxin_5 PF12724.2 KOO33279.1 - 0.1 12.5 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Flavodoxin domain TPR_14 PF13428.1 KOO33279.1 - 0.6 10.8 0.0 0.6 10.8 0.0 8.0 5 3 4 9 9 9 0 Tetratricopeptide repeat Apc3 PF12895.2 KOO33279.1 - 3.7 7.7 21.6 1.9 8.6 0.3 4.5 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 KOO33279.1 - 3.9 7.8 35.6 0.24 11.7 0.3 5.3 5 1 1 6 6 6 0 Tetratricopeptide repeat PDZ PF00595.19 KOO33281.1 - 2.7e-05 24.2 0.0 5.6e-05 23.2 0.0 1.6 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) DNA_ligase_A_M PF01068.16 KOO33282.1 - 2e-16 59.9 0.0 3.5e-16 59.1 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 KOO33282.1 - 2.9e-12 46.7 0.0 6.9e-12 45.5 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus Thiolase_N PF00108.18 KOO33283.1 - 1.3e-75 253.8 0.1 1.9e-75 253.2 0.0 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 KOO33283.1 - 4.2e-43 145.6 0.0 8.5e-43 144.6 0.0 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 KOO33283.1 - 1.9e-07 30.8 0.0 4.9e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SpoVAD PF07451.6 KOO33283.1 - 0.042 12.3 0.0 0.065 11.6 0.0 1.2 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) ACP_syn_III PF08545.5 KOO33283.1 - 0.31 10.7 1.9 18 5.0 0.0 3.3 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Chromo PF00385.19 KOO33284.1 - 3.9e-06 26.4 0.7 9.4e-06 25.2 0.2 1.9 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Nop14 PF04147.7 KOO33287.1 - 0.65 7.8 2.2 1.5 6.6 1.6 1.4 2 0 0 2 2 2 0 Nop14-like family DUF2457 PF10446.4 KOO33287.1 - 1.1 7.9 4.9 1.5 7.4 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Lactamase_B_2 PF12706.2 KOO33288.1 - 1.4e-20 73.6 0.0 2.6e-20 72.8 0.0 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 KOO33288.1 - 8e-07 28.8 0.0 1.4e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily YrhK PF14145.1 KOO33290.1 - 0.0034 16.9 32.7 0.014 15.0 0.4 6.0 3 2 2 5 5 5 4 YrhK-like protein Nucleotid_trans PF03407.11 KOO33291.1 - 6.3e-13 48.9 0.1 1.2e-06 28.4 0.0 2.2 2 0 0 2 2 2 2 Nucleotide-diphospho-sugar transferase GDPD PF03009.12 KOO33292.1 - 0.00097 18.7 0.0 0.0015 18.1 0.0 1.3 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family TPT PF03151.11 KOO33294.1 - 5.9e-09 35.7 7.6 9.3e-09 35.1 5.2 1.4 1 0 0 1 1 1 1 Triose-phosphate Transporter family EmrE PF13536.1 KOO33294.1 - 8.5e-05 22.7 6.6 8.5e-05 22.7 4.6 2.3 1 1 1 2 2 2 1 Multidrug resistance efflux transporter PGG PF13962.1 KOO33294.1 - 0.043 13.4 9.2 0.074 12.6 1.4 2.2 2 0 0 2 2 2 0 Domain of unknown function EamA PF00892.15 KOO33294.1 - 0.22 11.5 17.5 0.09 12.8 7.7 2.6 1 1 2 3 3 3 0 EamA-like transporter family TPR_11 PF13414.1 KOO33296.1 - 2.2e-55 184.2 15.6 2.4e-10 39.9 0.2 6.4 5 1 1 6 6 6 6 TPR repeat TPR_2 PF07719.12 KOO33296.1 - 1.5e-29 99.4 27.4 0.00048 19.8 0.0 12.0 12 0 0 12 12 11 7 Tetratricopeptide repeat TPR_1 PF00515.23 KOO33296.1 - 1.5e-28 97.2 1.9 0.0007 19.1 0.0 10.9 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_16 PF13432.1 KOO33296.1 - 9.6e-18 64.3 59.8 0.00015 22.3 0.2 7.5 6 1 1 7 7 6 5 Tetratricopeptide repeat TPR_12 PF13424.1 KOO33296.1 - 1.4e-14 53.7 34.0 0.0017 18.2 0.0 7.8 5 2 3 8 8 8 6 Tetratricopeptide repeat TPR_9 PF13371.1 KOO33296.1 - 2.5e-13 49.6 39.6 2.3e-05 24.1 0.5 7.5 5 2 2 8 8 8 5 Tetratricopeptide repeat TPR_19 PF14559.1 KOO33296.1 - 1.6e-12 47.5 29.3 0.02 15.2 1.0 7.0 5 2 2 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.1 KOO33296.1 - 1.1e-11 43.5 1.2 0.0013 18.4 0.0 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO33296.1 - 1.6e-09 37.5 56.1 0.023 15.2 0.7 10.9 4 3 7 11 11 10 7 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO33296.1 - 7.9e-08 32.0 3.0 0.099 12.5 0.0 3.9 2 1 1 3 3 3 3 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.1 KOO33296.1 - 1.3e-06 28.1 10.6 0.027 14.6 0.0 8.3 9 1 0 9 9 9 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO33296.1 - 2.2e-05 23.8 13.3 1.3 9.0 0.1 8.0 9 1 0 9 9 8 1 Tetratricopeptide repeat SHNi-TPR PF10516.4 KOO33296.1 - 0.071 12.3 5.3 3.4 7.0 0.0 4.5 5 0 0 5 5 5 0 SHNi-TPR NARP1 PF12569.3 KOO33296.1 - 0.18 10.5 10.5 0.99 8.0 0.1 4.0 3 2 1 5 5 5 0 NMDA receptor-regulated protein 1 Coatomer_E PF04733.9 KOO33296.1 - 0.36 9.9 7.0 7 5.7 1.3 3.7 3 1 1 4 4 4 0 Coatomer epsilon subunit TSA PF03249.8 KOO33296.1 - 8.2 4.8 12.2 12 4.2 8.4 1.1 1 0 0 1 1 1 0 Type specific antigen Lambda_tail_I PF06805.7 KOO33297.1 - 0.014 15.2 0.0 3.9 7.3 0.0 2.4 2 0 0 2 2 2 0 Bacteriophage lambda tail assembly protein I DUF433 PF04255.9 KOO33297.1 - 0.015 14.6 0.2 8 5.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF433) TFIIA_gamma_N PF02268.11 KOO33297.1 - 0.029 13.9 0.0 11 5.6 0.0 2.4 2 0 0 2 2 2 0 Transcription initiation factor IIA, gamma subunit, helical domain HrpF PF06266.7 KOO33297.1 - 0.3 11.2 7.2 5.2 7.2 0.2 3.4 2 2 1 3 3 3 0 HrpF protein EF-hand_1 PF00036.27 KOO33298.1 - 3e-13 48.0 2.8 2.7e-05 23.1 0.0 3.9 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.1 KOO33298.1 - 7.9e-11 40.7 0.8 6.4e-05 22.1 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 KOO33298.1 - 1.9e-10 40.7 0.5 2.2e-09 37.2 0.0 2.9 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO33298.1 - 3.8e-09 35.6 0.0 0.0014 18.3 0.0 3.5 3 0 0 3 3 2 2 EF-hand domain C2 PF00168.25 KOO33298.1 - 1.1e-08 34.8 0.0 3.2e-08 33.3 0.0 1.9 1 0 0 1 1 1 1 C2 domain EF-hand_8 PF13833.1 KOO33298.1 - 1.5e-06 27.7 0.3 0.00012 21.5 0.1 3.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.1 KOO33298.1 - 0.0022 17.8 0.0 0.0054 16.6 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain DUF433 PF04255.9 KOO33298.1 - 0.04 13.3 0.1 6.8 6.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF433) HrpF PF06266.7 KOO33298.1 - 0.041 14.0 8.1 2.3 8.3 0.1 3.7 2 1 1 3 3 3 0 HrpF protein EF-hand_4 PF12763.2 KOO33298.1 - 0.061 13.0 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand ATP-synt_E PF05680.7 KOO33298.1 - 3.9 7.4 7.1 0.53 10.2 1.3 2.2 2 0 0 2 2 2 0 ATP synthase E chain Helicase_C PF00271.26 KOO33299.1 - 1.9e-07 30.8 0.0 3.4e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF1373 PF07117.6 KOO33299.1 - 0.088 12.5 1.0 0.16 11.6 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1373) Ank_2 PF12796.2 KOO33300.1 - 2.3e-16 59.8 0.1 8.8e-16 58.0 0.0 2.1 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO33300.1 - 9.3e-15 53.6 4.5 2.6e-05 23.8 0.2 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 KOO33300.1 - 2.7e-12 46.5 6.6 3.8e-08 33.3 0.2 3.9 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Sel1 PF08238.7 KOO33300.1 - 3.5e-12 46.5 17.7 1.4e-07 31.9 2.0 5.4 5 0 0 5 5 5 2 Sel1 repeat Ank_4 PF13637.1 KOO33300.1 - 3.4e-10 40.1 0.5 1.4e-05 25.4 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) U-box PF04564.10 KOO33300.1 - 5.9e-10 38.9 0.0 1.2e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 U-box domain Ank_3 PF13606.1 KOO33300.1 - 1.1e-06 28.3 1.7 0.49 10.8 0.0 4.0 4 0 0 4 4 4 3 Ankyrin repeat zf-Nse PF11789.3 KOO33300.1 - 0.00023 20.6 0.0 0.0004 19.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Chorein_N PF12624.2 KOO33302.1 - 2.5e-06 27.0 0.0 3.7e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter TALPID3 PF15324.1 KOO33303.1 - 0.29 8.4 1.1 0.51 7.6 0.8 1.3 1 0 0 1 1 1 0 Hedgehog signalling target Pkinase PF00069.20 KOO33304.1 - 2.6e-31 108.7 0.0 3.8e-31 108.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33304.1 - 2.3e-23 82.6 0.0 5e-23 81.4 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO33304.1 - 9.4e-05 21.5 0.0 0.00014 20.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase PF00069.20 KOO33305.1 - 1.4e-46 158.7 0.0 1.9e-46 158.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33305.1 - 7.3e-39 133.3 0.0 1.3e-38 132.5 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO33305.1 - 4.3e-05 22.6 0.0 6.7e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO33305.1 - 0.018 14.7 0.1 0.073 12.7 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 KOO33305.1 - 0.13 11.2 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Tubulin PF00091.20 KOO33306.1 - 2.4e-41 141.9 0.0 2.7e-41 141.7 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Pro_isomerase PF00160.16 KOO33307.1 - 1.8e-27 96.4 0.0 2.4e-27 96.0 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Guanylate_kin PF00625.16 KOO33308.1 - 3.3e-42 143.9 0.0 4.7e-42 143.5 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase HEAT PF02985.17 KOO33309.1 - 0.0054 16.7 0.0 0.0094 15.9 0.0 1.4 1 0 0 1 1 1 1 HEAT repeat HEAT_2 PF13646.1 KOO33309.1 - 0.026 14.7 0.0 0.033 14.4 0.0 1.2 1 0 0 1 1 1 0 HEAT repeats HEAT_EZ PF13513.1 KOO33309.1 - 0.083 13.4 0.0 0.2 12.1 0.0 1.7 1 0 0 1 1 1 0 HEAT-like repeat WASH-7_mid PF14744.1 KOO33310.1 - 2.7e-86 289.6 0.0 1.4e-85 287.2 0.0 2.0 1 1 0 1 1 1 1 WASH complex subunit 7 WASH-7_N PF14745.1 KOO33310.1 - 4.4e-69 233.1 0.0 5.5e-66 222.9 0.0 2.1 1 1 1 2 2 2 2 WASH complex subunit 7, N-terminal WASH-7_C PF14746.1 KOO33310.1 - 3e-51 173.4 0.1 5.4e-51 172.5 0.0 1.4 1 0 0 1 1 1 1 WASH complex subunit 7, C-terminal zf-H2C2_2 PF13465.1 KOO33311.1 - 5.9e-34 114.6 50.4 8.4e-08 32.1 0.3 7.8 8 0 0 8 8 8 6 Zinc-finger double domain zf-C2H2 PF00096.21 KOO33311.1 - 4.7e-28 95.8 54.6 5.3e-05 23.3 1.4 7.4 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOO33311.1 - 1.5e-17 62.5 43.6 0.011 16.0 1.0 7.6 7 0 0 7 7 7 6 C2H2-type zinc finger CHORD PF04968.7 KOO33311.1 - 0.00083 19.5 40.1 0.53 10.5 0.8 6.6 1 1 5 6 6 6 5 CHORD zf-RING_2 PF13639.1 KOO33311.1 - 0.0016 18.2 0.5 0.0016 18.2 0.3 4.0 2 1 1 3 3 3 1 Ring finger domain MORN_2 PF07661.8 KOO33311.1 - 0.042 13.8 0.4 24 5.3 0.0 4.0 6 0 0 6 6 6 0 MORN repeat variant zf-C2H2_6 PF13912.1 KOO33311.1 - 0.044 13.6 0.1 0.044 13.6 0.1 7.1 7 0 0 7 7 7 0 C2H2-type zinc finger FANCL_C PF11793.3 KOO33311.1 - 2.4 8.1 30.0 0.25 11.3 0.8 7.5 2 2 6 8 8 8 0 FANCL C-terminal domain DnaJ PF00226.26 KOO33312.1 - 1.4e-21 75.9 0.1 2.8e-21 75.0 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain FATC PF02260.15 KOO33313.1 - 9.5e-07 28.1 0.1 2.1e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 FATC domain EF-hand_8 PF13833.1 KOO33313.1 - 0.2 11.2 0.0 1.3 8.6 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain pair Complex1_LYR_1 PF13232.1 KOO33314.1 - 1.1e-14 54.3 0.2 1.5e-14 53.8 0.1 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.10 KOO33314.1 - 2e-13 49.9 0.1 2.8e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.1 KOO33314.1 - 0.044 14.2 0.1 0.053 13.9 0.1 1.3 1 0 0 1 1 1 0 Complex1_LYR-like IQ PF00612.22 KOO33318.1 - 0.0003 20.1 9.9 1.6 8.6 0.3 4.6 4 0 0 4 4 4 3 IQ calmodulin-binding motif Pol_alpha_B_N PF08418.5 KOO33318.1 - 0.013 15.0 0.2 0.035 13.6 0.2 1.6 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal EF-hand_1 PF00036.27 KOO33319.1 - 1.9e-10 39.2 0.0 3.8e-06 25.8 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO33319.1 - 2.7e-10 40.2 0.2 6.7e-10 38.9 0.2 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO33319.1 - 9.1e-10 37.5 0.1 1.1e-05 24.8 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO33319.1 - 1.5e-09 37.3 0.2 0.0012 18.4 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO33319.1 - 4.7e-09 35.1 0.2 7.3e-07 28.2 0.2 2.4 2 0 0 2 2 2 2 EF hand WW PF00397.21 KOO33319.1 - 0.00031 20.5 0.4 0.00031 20.5 0.3 2.3 2 0 0 2 2 2 1 WW domain zf-C3HC4 PF00097.20 KOO33320.1 - 1.1e-08 34.5 10.7 1.1e-08 34.5 7.4 2.2 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO33320.1 - 2.8e-08 33.6 11.0 2.8e-08 33.6 7.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO33320.1 - 6.1e-07 29.1 8.9 6.1e-07 29.1 6.1 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.1 KOO33320.1 - 4.9e-06 26.1 8.0 4.9e-06 26.1 5.5 2.4 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RanBP PF00641.13 KOO33320.1 - 5e-06 25.5 7.7 5e-06 25.5 5.3 2.4 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others zf-C3HC4_4 PF15227.1 KOO33320.1 - 2.2e-05 24.2 9.8 2.2e-05 24.2 6.8 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 KOO33320.1 - 6.8e-05 22.5 8.6 6.8e-05 22.5 6.0 2.6 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_6 PF14835.1 KOO33320.1 - 0.00032 20.3 4.4 0.00032 20.3 3.1 1.9 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-MIZ PF02891.15 KOO33320.1 - 0.013 14.9 14.4 0.23 11.0 5.2 2.4 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger zf-Nse PF11789.3 KOO33320.1 - 0.016 14.7 6.6 0.016 14.7 4.5 1.8 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit DZR PF12773.2 KOO33320.1 - 0.058 13.2 12.7 0.23 11.3 0.3 2.8 2 1 0 2 2 2 0 Double zinc ribbon Ribosomal_L37e PF01907.14 KOO33320.1 - 1.8 8.3 8.8 0.083 12.7 1.8 1.9 2 0 0 2 2 1 0 Ribosomal protein L37e zf-4CXXC_R1 PF10497.4 KOO33320.1 - 6.2 7.0 7.6 4.2 7.5 0.3 2.7 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 KIAA1430 PF13879.1 KOO33321.1 - 0.00085 19.6 2.0 0.0019 18.5 0.0 2.4 2 1 0 2 2 2 1 KIAA1430 homologue FliD_C PF07195.7 KOO33321.1 - 1.1 8.5 5.7 3 7.0 3.9 2.0 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus NTPase_I-T PF01931.13 KOO33322.1 - 1.6e-14 53.9 0.0 1.9e-14 53.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF84 Amidohydro_1 PF01979.15 KOO33324.1 - 1.3e-35 123.6 0.0 7.9e-35 121.0 0.0 1.9 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.6 KOO33324.1 - 2.7e-05 23.5 0.9 0.15 11.2 0.0 2.7 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_5 PF13594.1 KOO33324.1 - 3.9e-05 23.3 0.1 0.00016 21.4 0.0 2.1 1 1 1 2 2 2 1 Amidohydrolase Amidohydro_4 PF13147.1 KOO33324.1 - 0.00011 22.2 4.0 0.14 12.1 0.3 2.6 3 0 0 3 3 3 2 Amidohydrolase DUF4200 PF13863.1 KOO33325.1 - 0.034 14.1 1.4 0.057 13.3 1.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) FeS PF04060.8 KOO33325.1 - 0.099 12.2 0.1 0.19 11.3 0.1 1.4 1 0 0 1 1 1 0 Putative Fe-S cluster Gag_spuma PF03276.9 KOO33325.1 - 0.8 7.9 7.0 1 7.5 4.9 1.1 1 0 0 1 1 1 0 Spumavirus gag protein GFO_IDH_MocA PF01408.17 KOO33328.1 - 6.5e-11 42.8 0.1 4e-10 40.2 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold EF-hand_1 PF00036.27 KOO33329.1 - 3e-22 76.1 0.1 9.4e-05 21.4 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO33329.1 - 1.8e-18 64.6 0.2 0.0064 16.2 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO33329.1 - 2.4e-16 59.6 0.7 1e-06 28.7 0.0 3.7 3 2 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO33329.1 - 4.6e-14 51.0 2.5 0.027 13.8 0.0 4.9 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.1 KOO33329.1 - 2.1e-07 30.4 1.7 2.1 8.0 0.1 4.6 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_4 PF12763.2 KOO33329.1 - 6.7e-07 28.9 0.0 0.035 13.8 0.0 2.6 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Terminase_5 PF06056.7 KOO33329.1 - 0.013 15.0 0.1 7.4 6.2 0.0 2.5 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) Cbl_N2 PF02761.9 KOO33329.1 - 0.026 14.5 0.0 10 6.2 0.0 2.8 2 2 0 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain YqfQ PF14181.1 KOO33329.1 - 0.045 13.8 0.4 2.2 8.3 0.0 2.2 2 0 0 2 2 2 0 YqfQ-like protein SCRG1 PF15224.1 KOO33329.1 - 0.056 13.2 0.3 17 5.3 0.0 2.5 2 0 0 2 2 2 0 Scrapie-responsive protein 1 HTH_23 PF13384.1 KOO33329.1 - 0.07 12.8 5.2 61 3.4 0.0 5.3 5 0 0 5 5 5 0 Homeodomain-like domain TetR_C PF02909.12 KOO33329.1 - 0.23 11.0 2.9 9.4 5.8 0.0 3.0 3 0 0 3 3 3 0 Tetracyclin repressor, C-terminal all-alpha domain MerR-DNA-bind PF09278.6 KOO33329.1 - 0.88 10.0 0.0 0.88 10.0 0.0 3.8 5 0 0 5 5 3 0 MerR, DNA binding 3Beta_HSD PF01073.14 KOO33330.1 - 2.6e-19 68.9 0.1 3.7e-19 68.5 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 KOO33330.1 - 2.3e-13 50.5 0.3 3.5e-13 49.9 0.2 1.2 1 0 0 1 1 1 1 NADH(P)-binding Amidohydro_2 PF04909.9 KOO33330.1 - 6.5e-12 45.5 0.3 3.7e-11 43.0 0.0 2.0 2 1 0 2 2 2 1 Amidohydrolase Epimerase PF01370.16 KOO33330.1 - 1.4e-11 44.2 0.0 2e-11 43.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 KOO33330.1 - 6.6e-06 25.2 0.2 8.8e-05 21.5 0.1 2.1 1 1 1 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.10 KOO33330.1 - 0.00019 20.4 2.0 0.0005 19.0 1.4 1.6 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.8 KOO33330.1 - 0.0013 18.0 0.0 0.0022 17.3 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family TrkA_N PF02254.13 KOO33330.1 - 0.0087 16.0 0.3 0.015 15.3 0.2 1.5 1 0 0 1 1 1 1 TrkA-N domain RmlD_sub_bind PF04321.12 KOO33330.1 - 0.02 13.8 0.1 0.027 13.3 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain SpoVS PF04232.7 KOO33330.1 - 0.12 11.9 0.1 1.9 8.1 0.0 2.2 2 0 0 2 2 2 0 Stage V sporulation protein S (SpoVS) DUF4658 PF15555.1 KOO33331.1 - 6.3 6.6 8.2 1.8 8.4 2.5 2.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4658) Lysine_decarbox PF03641.9 KOO33332.1 - 1.4e-22 79.9 0.0 1.9e-22 79.5 0.0 1.2 1 0 0 1 1 1 1 Possible lysine decarboxylase HMA PF00403.21 KOO33332.1 - 0.0028 17.7 0.0 0.0052 16.9 0.0 1.5 1 0 0 1 1 1 1 Heavy-metal-associated domain DAO PF01266.19 KOO33332.1 - 0.046 12.6 1.3 0.15 10.8 0.0 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase Ank_5 PF13857.1 KOO33333.1 - 4.3e-09 36.3 0.5 1.2e-06 28.5 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO33333.1 - 7.6e-07 29.3 0.0 1.2e-05 25.5 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO33333.1 - 2.4e-05 24.1 0.5 0.022 14.9 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.25 KOO33333.1 - 5e-05 22.8 4.1 0.01 15.6 0.1 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOO33333.1 - 0.00011 22.5 0.4 0.0076 16.7 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeats (many copies) LRR_6 PF13516.1 KOO33336.1 - 4.1e-34 112.7 8.7 0.00033 20.4 0.0 7.7 8 0 0 8 8 8 7 Leucine Rich repeat LRR_4 PF12799.2 KOO33336.1 - 8.3e-07 28.4 7.2 0.84 9.3 0.2 5.6 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO33336.1 - 9.6e-06 24.9 0.0 38 4.8 0.0 5.7 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_7 PF13504.1 KOO33336.1 - 3.4e-05 23.3 5.1 65 4.4 0.0 6.6 7 0 0 7 7 7 0 Leucine rich repeat YycC PF14174.1 KOO33336.1 - 0.00088 18.8 0.1 13 5.5 0.0 5.1 6 0 0 6 6 6 1 YycC-like protein SpoU_sub_bind PF08032.7 KOO33336.1 - 0.0025 17.9 5.2 0.97 9.6 0.1 4.2 3 3 1 4 4 4 1 RNA 2'-O ribose methyltransferase substrate binding DUF3017 PF11222.3 KOO33336.1 - 0.56 10.0 3.7 47 3.8 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3017) CbiG_N PF11760.3 KOO33336.1 - 1.5 8.6 18.9 5.5 6.7 1.3 5.5 2 2 2 5 5 5 0 Cobalamin synthesis G N-terminal LRR_8 PF13855.1 KOO33336.1 - 2.5 7.9 11.6 6.7 6.5 0.1 4.3 3 3 0 3 3 3 0 Leucine rich repeat HTH_23 PF13384.1 KOO33337.1 - 1.3e-05 24.6 0.1 1.3e-05 24.6 0.1 2.8 3 0 0 3 3 3 1 Homeodomain-like domain HTH_28 PF13518.1 KOO33337.1 - 0.0065 16.4 0.7 0.02 14.8 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.1 KOO33337.1 - 0.014 15.5 0.3 0.047 13.8 0.0 2.1 2 0 0 2 2 2 0 Winged helix-turn helix HTH_Tnp_ISL3 PF13542.1 KOO33337.1 - 0.014 14.5 0.1 0.039 13.1 0.1 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 rve PF00665.21 KOO33337.1 - 0.038 14.0 0.0 0.11 12.6 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain Ion_trans PF00520.26 KOO33338.1 - 5.4e-31 107.4 16.1 8.4e-31 106.7 11.1 1.3 1 0 0 1 1 1 1 Ion transport protein EF-hand_1 PF00036.27 KOO33338.1 - 0.00016 20.7 0.0 0.00047 19.2 0.0 1.9 1 0 0 1 1 1 1 EF hand PKD_channel PF08016.7 KOO33338.1 - 0.00039 18.9 19.0 0.0062 15.0 1.7 3.3 4 0 0 4 4 4 2 Polycystin cation channel EF-hand_6 PF13405.1 KOO33338.1 - 0.00076 19.1 0.0 0.0028 17.3 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.1 KOO33338.1 - 0.0014 17.8 0.0 0.0035 16.6 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO33338.1 - 0.1 12.7 0.0 0.27 11.3 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair Adeno_PX PF05829.7 KOO33338.1 - 2.2 7.8 4.7 0.3 10.6 0.2 1.9 2 0 0 2 2 2 0 Adenovirus late L2 mu core protein (Protein X) Peptidase_S28 PF05577.7 KOO33339.1 - 2.9e-79 266.6 0.0 3.8e-79 266.3 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_6 PF12697.2 KOO33339.1 - 0.00083 19.3 0.2 0.004 17.0 0.2 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S37 PF05576.6 KOO33339.1 - 0.0045 15.5 0.1 0.59 8.5 0.0 2.2 2 0 0 2 2 2 2 PS-10 peptidase S37 Peptidase_S9 PF00326.16 KOO33339.1 - 0.009 15.2 0.1 0.018 14.2 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.15 KOO33339.1 - 0.086 12.3 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold SKG6 PF08693.5 KOO33340.1 - 0.24 10.7 2.9 0.5 9.7 2.0 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Nucleotid_trans PF03407.11 KOO33341.1 - 1.9e-28 99.6 0.0 1e-22 80.9 0.0 2.2 2 0 0 2 2 2 2 Nucleotide-diphospho-sugar transferase FKBP_C PF00254.23 KOO33342.1 - 1.6e-29 101.7 0.0 2.2e-29 101.3 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase UBA PF00627.26 KOO33342.1 - 1.7e-07 30.8 0.2 3.3e-07 29.9 0.1 1.5 1 0 0 1 1 1 1 UBA/TS-N domain UBA_4 PF14555.1 KOO33342.1 - 0.0037 16.7 0.2 0.0077 15.7 0.1 1.5 1 0 0 1 1 1 1 UBA-like domain Pkinase PF00069.20 KOO33343.1 - 3.3e-42 144.4 0.0 5.6e-42 143.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33343.1 - 9e-38 129.8 0.0 2.1e-37 128.5 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Beta_helix PF13229.1 KOO33344.1 - 1.5e-07 31.3 9.3 1.5e-07 31.3 6.5 1.7 2 0 0 2 2 2 1 Right handed beta helix region NosD PF05048.8 KOO33344.1 - 0.00029 20.0 1.3 0.00055 19.1 0.9 1.4 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) Chlam_PMP PF02415.12 KOO33344.1 - 0.035 14.3 17.1 2.9 8.3 0.3 4.9 4 0 0 4 4 4 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat S4 PF01479.20 KOO33344.1 - 0.063 12.7 0.2 11 5.5 0.0 2.6 2 0 0 2 2 2 0 S4 domain TGT_C2 PF14810.1 KOO33345.1 - 0.14 12.0 0.0 4.4 7.2 0.0 2.2 2 0 0 2 2 2 0 Patch-forming domain C2 of tRNA-guanine transglycosylase Lactamase_B PF00753.22 KOO33346.1 - 1e-17 64.4 0.0 1.4e-17 64.0 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 KOO33346.1 - 0.0044 16.5 0.0 0.01 15.3 0.0 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain RMMBL PF07521.7 KOO33346.1 - 0.056 13.2 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 RNA-metabolising metallo-beta-lactamase Lactamase_B_3 PF13483.1 KOO33346.1 - 0.061 13.0 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 Beta-lactamase superfamily domain MgtE_N PF03448.12 KOO33348.1 - 0.021 15.1 4.7 2.8 8.2 0.6 3.1 1 1 0 2 2 2 0 MgtE intracellular N domain Abhydrolase_2 PF02230.11 KOO33349.1 - 3.3e-22 79.0 0.0 9.8e-22 77.4 0.0 1.7 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 KOO33349.1 - 9e-09 35.2 0.0 2.5e-08 33.8 0.0 1.7 1 1 1 2 2 2 1 Alpha/beta hydrolase family PIH1 PF08190.7 KOO33349.1 - 3e-06 26.9 0.0 3.7e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 pre-RNA processing PIH1/Nop17 Abhydrolase_6 PF12697.2 KOO33349.1 - 0.00013 21.9 4.3 0.0063 16.4 3.0 2.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 KOO33349.1 - 0.0012 18.4 0.2 0.0029 17.1 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 KOO33349.1 - 0.012 14.8 0.0 0.031 13.5 0.0 1.6 1 1 0 1 1 1 0 Prolyl oligopeptidase family Lipase_3 PF01764.20 KOO33349.1 - 0.087 12.4 0.1 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Lipase (class 3) EPL1 PF10513.4 KOO33350.1 - 2.7e-16 60.2 0.0 4.1e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 Enhancer of polycomb-like Nucleotid_trans PF03407.11 KOO33351.1 - 2e-16 60.4 0.0 2e-12 47.3 0.0 2.3 2 1 0 2 2 2 2 Nucleotide-diphospho-sugar transferase AAA PF00004.24 KOO33352.1 - 8e-08 32.5 0.0 1.1e-07 32.0 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 KOO33352.1 - 0.00034 19.7 0.0 0.00077 18.5 0.0 1.5 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KOO33352.1 - 0.00039 20.5 0.1 0.032 14.3 0.1 2.2 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 KOO33352.1 - 0.002 17.7 0.0 0.0029 17.1 0.0 1.2 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.1 KOO33352.1 - 0.0065 16.0 0.5 0.39 10.2 0.3 2.1 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 KOO33352.1 - 0.0096 15.6 0.1 0.029 14.1 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 KOO33352.1 - 0.032 13.9 0.3 0.063 13.0 0.2 1.6 1 1 0 1 1 1 0 Part of AAA domain AAA_17 PF13207.1 KOO33352.1 - 0.032 15.0 0.0 0.063 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 KOO33352.1 - 0.1 11.7 0.1 0.3 10.2 0.0 1.6 1 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA PF00004.24 KOO33353.1 - 3.7e-13 49.8 0.1 1e-12 48.3 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.16 KOO33353.1 - 1e-06 28.0 0.2 0.025 13.7 0.0 2.3 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 KOO33353.1 - 4.7e-05 23.0 0.0 0.00021 20.9 0.0 2.1 1 0 0 1 1 1 1 Part of AAA domain Sigma54_activ_2 PF14532.1 KOO33353.1 - 6e-05 23.1 0.0 0.00032 20.7 0.0 2.0 2 0 0 2 2 2 1 Sigma-54 interaction domain Sigma54_activat PF00158.21 KOO33353.1 - 9.7e-05 21.8 0.0 0.23 10.8 0.0 2.3 1 1 1 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.1 KOO33353.1 - 0.00017 21.7 0.2 0.19 11.8 0.1 2.6 1 1 1 2 2 2 2 AAA domain AAA_18 PF13238.1 KOO33353.1 - 0.0002 21.6 0.2 0.00067 19.9 0.1 2.0 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.1 KOO33353.1 - 0.00026 21.7 0.1 0.00078 20.2 0.1 1.9 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 KOO33353.1 - 0.00031 19.8 0.1 0.00098 18.2 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus Torsin PF06309.6 KOO33353.1 - 0.00098 19.0 0.0 0.0021 17.9 0.0 1.5 1 0 0 1 1 1 1 Torsin AAA_2 PF07724.9 KOO33353.1 - 0.0072 16.2 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) MCM PF00493.18 KOO33353.1 - 0.0093 14.8 0.5 0.032 13.0 0.0 2.0 2 1 0 2 2 2 1 MCM2/3/5 family AAA_28 PF13521.1 KOO33353.1 - 0.015 15.2 2.7 0.65 9.9 0.1 3.3 3 0 0 3 3 3 0 AAA domain AAA_5 PF07728.9 KOO33353.1 - 0.03 14.0 0.1 0.091 12.4 0.1 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 KOO33353.1 - 0.037 13.4 0.0 0.11 11.9 0.0 1.8 1 0 0 1 1 1 0 IstB-like ATP binding protein ABC_tran PF00005.22 KOO33353.1 - 0.094 13.0 0.1 0.34 11.2 0.0 1.9 2 0 0 2 2 2 0 ABC transporter AAA_11 PF13086.1 KOO33353.1 - 0.14 11.6 0.1 0.35 10.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.1 KOO33353.1 - 0.15 11.6 0.2 0.27 10.7 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 KOO33353.1 - 0.26 11.2 0.1 0.26 11.2 0.1 3.4 3 1 1 4 4 4 0 AAA ATPase domain F5_F8_type_C PF00754.20 KOO33355.1 - 0.013 15.2 0.0 0.029 14.2 0.0 1.5 1 0 0 1 1 1 0 F5/8 type C domain hSac2 PF12456.3 KOO33356.1 - 2e-10 40.0 0.0 3.4e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Inositol phosphatase DUF2505 PF10698.4 KOO33357.1 - 1.1e-09 37.9 0.0 1.9e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2505) Ank PF00023.25 KOO33358.1 - 3e-23 80.4 0.4 3.7e-09 35.9 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.2 KOO33358.1 - 3.3e-23 81.8 0.3 1.3e-11 44.6 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO33358.1 - 3.5e-19 68.3 1.9 3.4e-10 39.8 0.2 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO33358.1 - 5.1e-19 68.2 0.1 9.6e-14 51.4 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO33358.1 - 1e-16 59.3 0.1 5.5e-06 26.1 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat PspA_IM30 PF04012.7 KOO33359.1 - 0.018 14.3 1.1 0.018 14.3 0.7 1.7 2 0 0 2 2 2 0 PspA/IM30 family DUF4019 PF13211.1 KOO33359.1 - 0.091 13.0 0.1 0.21 11.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4019) SET PF00856.23 KOO33360.1 - 0.0017 18.6 0.0 0.0031 17.8 0.0 1.3 1 1 0 1 1 1 1 SET domain XPG_N PF00752.12 KOO33362.1 - 0.089 13.0 0.0 0.095 12.9 0.0 1.2 1 0 0 1 1 1 0 XPG N-terminal domain TTL PF03133.10 KOO33363.1 - 1.7e-69 233.9 0.0 8.4e-69 231.7 0.0 1.9 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 KOO33363.1 - 8.1e-10 37.9 0.1 1.8e-06 26.9 0.0 3.0 2 1 1 3 3 3 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.1 KOO33363.1 - 0.017 14.1 0.0 1.3 8.0 0.0 2.2 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.9 KOO33363.1 - 0.069 13.0 0.0 0.64 9.8 0.0 2.2 2 0 0 2 2 2 0 ATP-grasp domain CP_ATPgrasp_1 PF04174.8 KOO33363.1 - 0.072 11.7 0.0 0.4 9.2 0.0 2.1 2 0 0 2 2 2 0 A circularly permuted ATPgrasp Pkinase PF00069.20 KOO33364.1 - 1.8e-62 210.8 0.0 2e-62 210.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33364.1 - 1.6e-33 115.9 0.0 1.8e-33 115.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO33364.1 - 6.2e-05 22.1 0.1 8.9e-05 21.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO33364.1 - 9.9e-05 22.1 0.2 0.00046 19.9 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO33364.1 - 0.0006 18.8 0.0 0.0086 15.0 0.0 2.2 1 1 1 2 2 2 1 Kinase-like YukC PF10140.4 KOO33364.1 - 0.098 11.2 0.0 0.14 10.6 0.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Glyco_transf_29 PF00777.13 KOO33366.1 - 5.1e-30 104.5 0.0 1.7e-15 56.8 0.0 2.3 2 1 0 2 2 2 2 Glycosyltransferase family 29 (sialyltransferase) ABC2_membrane PF01061.19 KOO33367.1 - 7.6e-15 54.6 0.3 1.2e-14 54.0 0.2 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.22 KOO33367.1 - 5.4e-13 49.4 0.0 2.4e-12 47.3 0.0 2.0 2 1 1 3 3 3 1 ABC transporter EF-hand_6 PF13405.1 KOO33367.1 - 1.1e-12 46.6 6.1 0.00091 18.9 0.0 3.8 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.27 KOO33367.1 - 2.2e-12 45.2 11.6 0.00057 19.0 0.1 3.9 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.1 KOO33367.1 - 3.5e-10 39.8 1.5 8.8e-06 25.7 0.0 3.2 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO33367.1 - 3.3e-08 33.0 5.0 7.9e-06 25.4 0.4 3.6 2 2 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO33367.1 - 4e-06 25.9 16.7 0.00025 20.2 0.1 3.9 4 0 0 4 4 4 2 EF hand AAA_21 PF13304.1 KOO33367.1 - 0.00014 21.8 0.0 0.00022 21.2 0.0 1.3 1 1 0 1 1 1 1 AAA domain ABC2_membrane_3 PF12698.2 KOO33367.1 - 0.0028 16.7 2.0 0.0045 16.0 1.4 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein SbcCD_C PF13558.1 KOO33367.1 - 0.036 13.9 0.2 0.49 10.3 0.0 2.8 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit FA_hydroxylase PF04116.8 KOO33368.1 - 1.4e-11 44.7 10.0 4.3e-11 43.2 7.0 1.9 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily PsbI PF02532.9 KOO33368.1 - 0.083 12.5 0.2 0.28 10.8 0.1 1.9 1 0 0 1 1 1 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) Protocadherin PF08374.6 KOO33369.1 - 0.06 12.9 0.2 0.13 11.8 0.1 1.5 1 0 0 1 1 1 0 Protocadherin Exonuc_VII_L PF02601.10 KOO33369.1 - 1.1 8.4 2.5 1.6 7.8 1.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit CcmD PF04995.9 KOO33369.1 - 6 6.6 6.6 1 9.1 1.2 2.3 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) MMR_HSR1 PF01926.18 KOO33370.1 - 1.8e-19 69.7 0.0 2.3e-19 69.4 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 KOO33370.1 - 1.6e-06 27.4 0.0 3.1e-06 26.4 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 KOO33370.1 - 3e-06 26.6 0.0 3.8e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 KOO33370.1 - 0.00013 21.8 0.2 0.054 13.3 0.0 2.2 1 1 1 2 2 2 2 Dynamin family AIG1 PF04548.11 KOO33370.1 - 0.0015 17.6 0.0 0.002 17.2 0.0 1.2 1 0 0 1 1 1 1 AIG1 family SRPRB PF09439.5 KOO33370.1 - 0.003 16.7 0.2 0.029 13.5 0.1 2.0 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 KOO33370.1 - 0.003 17.0 0.0 0.0083 15.5 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain DUF2872 PF11071.3 KOO33370.1 - 0.0054 16.6 0.0 0.0077 16.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2872) Resolvase PF00239.16 KOO33370.1 - 0.015 15.1 0.9 0.022 14.6 0.6 1.3 1 0 0 1 1 1 0 Resolvase, N terminal domain AAA_22 PF13401.1 KOO33370.1 - 0.061 13.4 0.1 0.13 12.4 0.1 1.7 1 1 0 1 1 1 0 AAA domain Miro PF08477.8 KOO33370.1 - 0.083 13.3 0.0 0.15 12.5 0.0 1.6 1 1 0 1 1 1 0 Miro-like protein LRR_6 PF13516.1 KOO33371.1 - 3.2e-11 42.0 4.4 0.6 10.3 0.0 9.2 10 1 0 10 10 10 2 Leucine Rich repeat LRR_1 PF00560.28 KOO33371.1 - 1.5e-06 27.4 4.2 43 4.7 0.1 8.3 8 2 0 8 8 8 0 Leucine Rich Repeat LRR_4 PF12799.2 KOO33371.1 - 1.7e-06 27.4 0.3 8 6.2 0.0 6.7 1 1 5 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO33371.1 - 2.2e-06 27.2 2.7 0.078 12.7 0.0 4.6 3 2 2 5 5 5 2 Leucine rich repeat LRR_7 PF13504.1 KOO33371.1 - 3.2e-06 26.4 14.5 7.1 7.3 0.0 9.5 9 2 0 9 9 9 1 Leucine rich repeat YadA_head PF05658.9 KOO33372.1 - 0.026 14.7 3.1 0.026 14.7 2.2 4.5 5 1 1 6 6 6 0 Head domain of trimeric autotransporter adhesin KRTAP PF11759.3 KOO33372.1 - 1.1 9.5 22.8 9e+02 0.2 15.8 2.6 1 1 0 1 1 1 0 Keratin-associated matrix Rad60-SLD PF11976.3 KOO33373.1 - 4.5e-16 58.2 0.0 8.1e-16 57.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 KOO33373.1 - 0.00013 21.2 0.0 0.00029 20.1 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Borrelia_P83 PF05262.6 KOO33373.1 - 0.0022 16.3 16.2 0.0033 15.7 11.2 1.2 1 0 0 1 1 1 1 Borrelia P83/100 protein WEMBL PF05701.6 KOO33373.1 - 0.0063 15.0 25.9 0.013 14.0 17.9 1.4 1 0 0 1 1 1 1 Weak chloroplast movement under blue light Nucleoporin_FG PF13634.1 KOO33373.1 - 0.018 15.2 29.3 0.044 14.0 20.3 1.7 1 0 0 1 1 1 0 Nucleoporin FG repeat region ISG65-75 PF11727.3 KOO33373.1 - 0.8 8.7 15.7 1.8 7.5 10.9 1.6 1 0 0 1 1 1 0 Invariant surface glycoprotein AAA_13 PF13166.1 KOO33373.1 - 1.6 7.0 9.0 2.4 6.4 6.3 1.1 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.3 KOO33373.1 - 2.4 5.4 17.4 3.7 4.7 12.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) HSP70 PF00012.15 KOO33373.1 - 2.8 5.7 15.0 5.5 4.7 10.4 1.4 1 0 0 1 1 1 0 Hsp70 protein CSS-motif PF12792.2 KOO33373.1 - 3.2 7.0 8.4 22 4.2 0.4 3.2 2 1 1 3 3 3 0 CSS motif domain associated with EAL SAPS PF04499.10 KOO33373.1 - 6.6 5.2 8.2 12 4.4 5.7 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Glyco_hydro_18 PF00704.23 KOO33375.1 - 0.0018 17.8 0.0 0.0043 16.5 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Transmemb_17 PF09799.4 KOO33376.1 - 1.5e-18 67.0 9.7 2.4e-18 66.4 6.7 1.3 1 0 0 1 1 1 1 Predicted membrane protein FYVE PF01363.16 KOO33377.1 - 8.1e-18 64.0 15.2 1.5e-17 63.1 10.5 1.4 1 0 0 1 1 1 1 FYVE zinc finger D-aminoacyl_C PF07908.7 KOO33377.1 - 0.066 12.5 0.0 0.14 11.4 0.0 1.6 1 0 0 1 1 1 0 D-aminoacylase, C-terminal region FYVE_2 PF02318.11 KOO33377.1 - 0.26 11.1 9.3 0.57 10.0 6.4 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger Herpes_VP19C PF03327.9 KOO33378.1 - 0.089 11.6 1.1 1 8.2 0.0 2.5 2 1 1 3 3 3 0 Herpesvirus capsid shell protein VP19C AAA_16 PF13191.1 KOO33379.1 - 6.1e-12 45.9 0.7 2.3e-10 40.7 0.1 2.3 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.7 KOO33379.1 - 1.5e-07 31.2 0.0 2.6e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 NACHT domain KAP_NTPase PF07693.9 KOO33379.1 - 0.0014 17.7 0.0 0.036 13.0 0.0 2.2 2 0 0 2 2 2 1 KAP family P-loop domain PIF1 PF05970.9 KOO33379.1 - 0.038 12.9 0.0 0.054 12.4 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase AAA_25 PF13481.1 KOO33379.1 - 0.05 12.9 0.2 0.19 11.0 0.1 2.0 1 1 0 1 1 1 0 AAA domain LRR_6 PF13516.1 KOO33380.1 - 8.3e-10 37.7 0.5 0.11 12.6 0.0 4.8 5 0 0 5 5 5 4 Leucine Rich repeat LRR_1 PF00560.28 KOO33380.1 - 0.0013 18.4 0.1 26 5.3 0.0 4.6 5 0 0 5 5 5 1 Leucine Rich Repeat Glucokinase PF02685.11 KOO33382.1 - 2.9e-77 259.5 0.0 2.5e-43 148.0 0.0 2.3 2 0 0 2 2 2 2 Glucokinase Methyltransf_16 PF10294.4 KOO33382.1 - 1.1e-17 64.0 0.0 2.1e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase EF-hand_1 PF00036.27 KOO33382.1 - 3.8e-06 25.8 0.2 7.4e-06 24.9 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO33382.1 - 8e-06 25.3 0.3 2.6e-05 23.7 0.1 1.9 2 0 0 2 2 1 1 EF-hand domain EF-hand_7 PF13499.1 KOO33382.1 - 4e-05 23.6 0.1 8.4e-05 22.6 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair MTS PF05175.9 KOO33382.1 - 0.00059 19.2 0.0 0.0011 18.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain EF-hand_5 PF13202.1 KOO33382.1 - 0.00072 18.7 0.1 0.0014 17.9 0.1 1.4 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 KOO33382.1 - 0.00095 18.7 0.0 0.002 17.7 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair PrmA PF06325.8 KOO33382.1 - 0.026 13.6 0.0 0.041 12.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.1 KOO33382.1 - 0.1 12.3 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_26 PF13659.1 KOO33382.1 - 0.1 12.6 1.3 0.27 11.2 0.9 1.6 1 1 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.10 KOO33382.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PAN_4 PF14295.1 KOO33382.1 - 0.14 11.9 2.9 0.092 12.4 0.3 2.0 2 0 0 2 2 2 0 PAN domain MTHFR PF02219.12 KOO33383.1 - 8.9e-06 24.9 0.0 1.2e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase DUF1835 PF08874.5 KOO33385.1 - 0.0056 16.6 0.7 0.0099 15.8 0.4 1.5 1 1 1 2 2 2 1 Domain of unknown function (DUF1835) BORG_CEP PF14957.1 KOO33385.1 - 0.48 11.3 3.0 0.61 11.0 2.0 1.1 1 0 0 1 1 1 0 Cdc42 effector TRAP_alpha PF03896.11 KOO33385.1 - 2.5 7.0 6.0 2.7 6.9 4.2 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF4332 PF14229.1 KOO33386.1 - 0.015 15.2 0.0 0.034 14.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) PALP PF00291.20 KOO33387.1 - 0.0023 17.1 0.0 0.0044 16.2 0.0 1.5 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF4580 PF15162.1 KOO33387.1 - 0.16 11.3 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4580) Trp_syntA PF00290.15 KOO33388.1 - 2e-70 236.3 0.1 2.1e-69 232.9 0.1 2.0 1 1 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.20 KOO33388.1 - 2.1e-24 86.3 0.1 4.4e-24 85.2 0.1 1.5 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme HORMA PF02301.13 KOO33389.1 - 9.9e-39 132.9 0.3 1.1e-38 132.7 0.2 1.0 1 0 0 1 1 1 1 HORMA domain ATG13 PF10033.4 KOO33389.1 - 0.02 14.3 0.1 0.034 13.5 0.1 1.5 1 1 0 1 1 1 0 Autophagy-related protein 13 FlxA PF14282.1 KOO33389.1 - 0.2 11.6 0.2 0.2 11.6 0.1 1.8 2 0 0 2 2 2 0 FlxA-like protein Utp14 PF04615.8 KOO33390.1 - 6.4e-99 332.1 64.8 8.5e-53 179.6 24.2 3.1 1 1 2 3 3 3 2 Utp14 protein Leucyl-specific PF14795.1 KOO33390.1 - 0.83 9.5 15.6 0.71 9.7 0.8 3.3 3 0 0 3 3 3 0 Leucine-tRNA synthetase-specific domain DUF4238 PF14022.1 KOO33390.1 - 1.8 7.7 5.8 0.97 8.6 2.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4238) TFIIF_alpha PF05793.7 KOO33390.1 - 8.3 4.6 45.3 0.078 11.3 7.5 2.5 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Ank_2 PF12796.2 KOO33391.1 - 7.6e-21 74.2 1.4 1.3e-10 41.4 0.1 1.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO33391.1 - 1.4e-15 56.1 0.9 1.3e-07 31.0 0.2 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 KOO33391.1 - 2.1e-10 40.8 0.6 2.3e-09 37.5 0.2 2.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO33391.1 - 8.6e-08 32.1 1.3 0.00013 22.1 0.3 3.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO33391.1 - 1e-06 28.3 0.2 0.0035 17.4 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat F-box-like PF12937.2 KOO33391.1 - 8.1e-05 22.2 1.6 0.00023 20.8 1.1 1.8 1 0 0 1 1 1 1 F-box-like Elongin_A PF06881.6 KOO33391.1 - 0.00025 21.3 0.1 0.00025 21.3 0.1 1.6 2 0 0 2 2 2 1 RNA polymerase II transcription factor SIII (Elongin) subunit A PAN_4 PF14295.1 KOO33392.1 - 0.13 11.9 2.2 0.43 10.3 1.5 1.9 1 0 0 1 1 1 0 PAN domain Pox_P4A PF03395.9 KOO33392.1 - 0.17 9.4 0.0 0.23 8.9 0.0 1.0 1 0 0 1 1 1 0 Poxvirus P4A protein Isochorismatase PF00857.15 KOO33393.1 - 2.8e-30 105.5 0.0 5.2e-30 104.6 0.0 1.4 1 0 0 1 1 1 1 Isochorismatase family 2OG-FeII_Oxy_2 PF13532.1 KOO33393.1 - 3.5e-12 46.5 0.0 6e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.1 KOO33393.1 - 1.3e-10 41.6 0.7 8.4e-09 35.8 0.1 2.5 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily zf-NADH-PPase PF09297.6 KOO33393.1 - 0.004 16.6 0.7 0.0088 15.5 0.5 1.6 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain Oxygenase-NA PF09859.4 KOO33393.1 - 0.0069 15.7 0.0 0.018 14.3 0.0 1.7 1 0 0 1 1 1 1 Oxygenase, catalysing oxidative methylation of damaged DNA 2OG-FeII_Oxy_5 PF13759.1 KOO33393.1 - 0.13 12.5 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase DUF3293 PF11697.3 KOO33394.1 - 1.7 8.8 4.7 6.9 6.8 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3293) DapB_N PF01113.15 KOO33395.1 - 2.5e-16 59.7 0.0 4.4e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus DapB_C PF05173.9 KOO33395.1 - 2.7e-08 33.6 0.0 6.9e-08 32.3 0.0 1.7 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, C-terminus DUF167 PF02594.11 KOO33396.1 - 1.8e-12 46.9 0.0 3.4e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 Actin PF00022.14 KOO33398.1 - 5.7e-70 235.7 0.0 3.2e-69 233.2 0.0 1.8 1 1 1 2 2 2 1 Actin MreB_Mbl PF06723.8 KOO33398.1 - 0.11 11.0 0.0 3 6.3 0.0 2.0 2 0 0 2 2 2 0 MreB/Mbl protein FKBP_C PF00254.23 KOO33399.1 - 3.3e-20 71.8 0.0 5.8e-20 71.1 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_5 PF13202.1 KOO33399.1 - 6.4e-07 28.4 1.7 0.00096 18.3 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.27 KOO33399.1 - 4e-06 25.7 2.6 0.0073 15.5 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO33399.1 - 1.3e-05 24.6 1.0 0.0083 15.9 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO33399.1 - 1.8e-05 24.7 1.1 5.2e-05 23.3 0.7 1.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO33399.1 - 0.00014 21.3 0.8 0.38 10.4 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair CNP1 PF08750.6 KOO33399.1 - 0.1 12.2 0.0 0.26 10.9 0.0 1.6 2 0 0 2 2 2 0 CNP1-like family Iron_permease PF04120.7 KOO33399.1 - 0.19 11.3 1.1 0.3 10.6 0.7 1.2 1 0 0 1 1 1 0 Low affinity iron permease GHMP_kinases_C PF08544.8 KOO33400.1 - 4.2e-11 42.8 0.1 2e-10 40.7 0.1 2.2 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.21 KOO33400.1 - 6.8e-07 29.2 0.7 4.1e-06 26.7 0.1 2.6 2 0 0 2 2 2 1 GHMP kinases N terminal domain ATG11 PF10377.4 KOO33401.1 - 4.9e-05 23.2 0.0 5.4e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 11 Filamin PF00630.14 KOO33402.1 - 3.3e-42 143.1 0.0 3.2e-08 34.0 0.0 6.2 5 1 0 5 5 5 5 Filamin/ABP280 repeat A2M_N PF01835.14 KOO33402.1 - 0.0023 18.1 0.0 0.071 13.3 0.0 2.8 2 0 0 2 2 2 1 MG2 domain VWA PF00092.23 KOO33403.1 - 1.3e-35 122.6 0.0 1.2e-22 80.4 0.0 2.0 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.1 KOO33403.1 - 4.3e-25 88.8 7.3 1.2e-16 61.3 1.1 2.0 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_CoxE PF05762.9 KOO33403.1 - 2.8e-11 43.0 0.1 9.8e-05 21.5 0.0 2.2 2 0 0 2 2 2 2 VWA domain containing CoxE-like protein LexA_DNA_bind PF01726.11 KOO33403.1 - 0.0035 16.8 0.0 0.57 9.7 0.0 3.1 3 0 0 3 3 3 1 LexA DNA binding domain DUF1194 PF06707.6 KOO33403.1 - 0.0098 14.8 1.2 0.054 12.4 0.2 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1194) VWA_3 PF13768.1 KOO33403.1 - 0.011 15.4 0.2 1.2 8.8 0.0 2.2 2 0 0 2 2 2 0 von Willebrand factor type A domain ABC2_membrane PF01061.19 KOO33404.1 - 4e-34 117.6 19.7 4e-34 117.6 13.7 1.8 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.22 KOO33404.1 - 2.6e-28 99.0 0.0 3.8e-28 98.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 KOO33404.1 - 1.3e-08 35.1 0.0 0.00057 19.9 0.0 2.2 2 0 0 2 2 2 2 AAA domain ABC2_membrane_2 PF12679.2 KOO33404.1 - 0.00013 20.9 8.1 0.00013 20.9 5.6 2.3 2 0 0 2 2 2 1 ABC-2 family transporter protein AAA_29 PF13555.1 KOO33404.1 - 0.00035 20.0 0.2 0.00093 18.6 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF258 PF03193.11 KOO33404.1 - 0.00036 19.7 0.0 0.00062 18.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 SMC_N PF02463.14 KOO33404.1 - 0.00071 18.8 0.1 0.77 8.9 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain PDR_assoc PF08370.6 KOO33404.1 - 0.0025 17.3 0.2 0.0072 15.8 0.1 1.8 1 0 0 1 1 1 1 Plant PDR ABC transporter associated ABC2_membrane_3 PF12698.2 KOO33404.1 - 0.0044 16.0 27.2 0.014 14.4 18.8 1.7 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_16 PF13191.1 KOO33404.1 - 0.0061 16.5 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.18 KOO33404.1 - 0.0071 16.2 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 KOO33404.1 - 0.019 15.1 0.1 0.1 12.7 0.1 2.1 1 1 0 1 1 1 0 AAA domain Miro PF08477.8 KOO33404.1 - 0.028 14.9 0.0 0.055 13.9 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein AAA_17 PF13207.1 KOO33404.1 - 0.03 15.1 0.2 0.073 13.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 KOO33404.1 - 0.031 13.6 0.1 0.12 11.7 0.1 1.9 2 0 0 2 2 2 0 AAA domain cobW PF02492.14 KOO33404.1 - 0.034 13.5 0.0 0.055 12.9 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.1 KOO33404.1 - 0.046 14.0 0.1 0.074 13.3 0.1 1.2 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 KOO33404.1 - 0.05 12.4 1.1 0.12 11.2 0.2 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_33 PF13671.1 KOO33404.1 - 0.051 13.4 0.0 0.083 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.12 KOO33404.1 - 0.064 12.7 0.4 0.16 11.4 0.1 1.8 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_28 PF13521.1 KOO33404.1 - 0.071 13.0 0.1 0.12 12.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 KOO33404.1 - 0.079 12.3 0.2 0.13 11.6 0.1 1.3 1 0 0 1 1 1 0 AAA-like domain Dynamin_N PF00350.18 KOO33404.1 - 0.079 12.7 0.2 0.15 11.8 0.1 1.3 1 0 0 1 1 1 0 Dynamin family AAA_30 PF13604.1 KOO33404.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AFG1_ATPase PF03969.11 KOO33404.1 - 0.15 10.8 0.0 0.4 9.4 0.0 1.7 1 1 0 1 1 1 0 AFG1-like ATPase FeoB_N PF02421.13 KOO33404.1 - 0.15 11.2 0.1 0.33 10.2 0.1 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_18 PF13238.1 KOO33404.1 - 0.21 11.8 0.1 0.41 10.9 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.1 KOO33404.1 - 0.46 9.4 0.0 9.1 5.2 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain PDR_CDR PF06422.7 KOO33404.1 - 1.3 8.7 6.4 0.097 12.3 0.6 1.8 2 0 0 2 2 1 0 CDR ABC transporter TFIIA PF03153.8 KOO33405.1 - 0.0065 16.4 10.0 0.009 15.9 6.9 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit V_ATPase_I PF01496.14 KOO33405.1 - 3.1 5.5 7.5 4.2 5.0 5.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Nop25 PF09805.4 KOO33405.1 - 5.6 7.0 23.3 9.3 6.3 16.1 1.4 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) CDC27 PF09507.5 KOO33405.1 - 6.2 5.9 29.9 9.4 5.3 20.7 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Methyltransf_16 PF10294.4 KOO33406.1 - 7.7e-15 54.7 0.0 9.1e-15 54.5 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.1 KOO33406.1 - 0.0018 17.9 0.0 0.002 17.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain SET PF00856.23 KOO33407.1 - 4e-10 40.2 0.4 4.2e-09 36.8 0.2 2.5 2 1 0 2 2 2 1 SET domain Ribosomal_S3_C PF00189.15 KOO33408.1 - 7.1e-13 48.5 0.6 1.3e-12 47.7 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.12 KOO33408.1 - 8.7e-12 44.4 0.4 1.8e-11 43.4 0.3 1.6 1 0 0 1 1 1 1 KH domain Lipase_GDSL_2 PF13472.1 KOO33409.1 - 0.00052 20.2 1.0 0.00074 19.7 0.1 1.7 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Trns_repr_metal PF02583.12 KOO33411.1 - 0.065 13.4 0.0 5.1 7.3 0.0 2.7 2 0 0 2 2 2 0 Metal-sensitive transcriptional repressor Ank PF00023.25 KOO33414.1 - 1.2e-133 428.7 44.9 5.1e-08 32.3 0.1 18.0 18 0 0 18 18 18 17 Ankyrin repeat Ank_2 PF12796.2 KOO33414.1 - 2.6e-117 383.4 45.6 3.7e-22 78.4 1.3 9.4 1 1 5 8 8 8 8 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO33414.1 - 3.6e-100 317.7 16.4 1.3e-05 25.0 0.0 17.4 17 0 0 17 17 17 15 Ankyrin repeat Ank_4 PF13637.1 KOO33414.1 - 4.5e-87 285.0 31.4 1e-09 38.6 0.0 13.2 4 1 10 14 14 14 13 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO33414.1 - 1.8e-67 221.8 42.5 6.2e-09 35.8 0.1 14.2 3 2 13 16 16 16 16 Ankyrin repeats (many copies) SAC3 PF12209.3 KOO33414.1 - 2.2e-06 27.6 0.0 2.1e+02 2.1 0.0 9.7 13 0 0 13 13 13 0 Leucine permease transcriptional regulator helical domain Exotox-A_target PF09102.5 KOO33414.1 - 0.004 16.6 8.6 15 5.0 0.0 5.3 1 1 7 8 8 8 0 Exotoxin A, targeting SseB_C PF14581.1 KOO33414.1 - 0.011 15.5 3.4 71 3.3 0.0 5.8 5 2 5 10 10 10 0 SseB protein C-terminal domain FrhB_FdhB_N PF04422.8 KOO33414.1 - 0.089 12.6 1.0 1.2 9.0 0.1 2.7 2 0 0 2 2 2 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term Phenol_Hydrox PF02332.13 KOO33414.1 - 0.1 11.9 13.3 0.31 10.3 0.1 5.9 3 1 3 9 9 9 0 Methane/Phenol/Toluene Hydroxylase PP_kinase_C PF13090.1 KOO33414.1 - 9.1 4.7 21.4 47 2.4 0.1 8.5 4 3 7 11 11 11 0 Polyphosphate kinase C-terminal domain NTP_transf_3 PF12804.2 KOO33417.1 - 3.3e-08 33.7 0.0 7.3e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 MobA-like NTP transferase domain NTP_transferase PF00483.18 KOO33417.1 - 5.3e-07 29.1 0.0 7.2e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase IspD PF01128.14 KOO33417.1 - 0.0018 17.8 0.0 0.0028 17.1 0.0 1.3 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase AAA_2 PF07724.9 KOO33418.1 - 2.9e-19 69.6 0.0 6.3e-19 68.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 KOO33418.1 - 3.5e-10 40.1 0.0 9.4e-10 38.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KOO33418.1 - 1.9e-07 30.8 0.0 6.4e-07 29.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Torsin PF06309.6 KOO33418.1 - 2.9e-05 23.9 0.0 5.6e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Torsin Sigma54_activat PF00158.21 KOO33418.1 - 0.00072 19.0 0.0 0.0051 16.3 0.0 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_22 PF13401.1 KOO33418.1 - 0.0016 18.5 0.1 0.013 15.5 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.1 KOO33418.1 - 0.0054 17.5 0.5 0.023 15.5 0.0 2.3 3 0 0 3 3 2 1 AAA domain AAA_16 PF13191.1 KOO33418.1 - 0.0074 16.2 12.3 0.032 14.2 0.0 4.2 3 2 1 4 4 4 1 AAA ATPase domain RNA_helicase PF00910.17 KOO33418.1 - 0.028 14.5 0.0 0.061 13.5 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.1 KOO33418.1 - 0.029 14.2 0.0 0.067 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 KOO33418.1 - 0.063 12.6 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein NACHT PF05729.7 KOO33418.1 - 0.076 12.6 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 NACHT domain ResIII PF04851.10 KOO33418.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_23 PF13476.1 KOO33418.1 - 0.15 12.3 0.6 0.29 11.4 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.1 KOO33418.1 - 0.34 10.2 5.5 0.9 8.9 0.1 2.9 3 1 0 3 3 3 0 AAA domain GBP PF02263.14 KOO33419.1 - 1.5e-09 37.3 0.0 2.3e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Arch_ATPase PF01637.13 KOO33419.1 - 0.024 14.3 0.0 0.06 13.0 0.0 1.6 1 0 0 1 1 1 0 Archaeal ATPase adh_short PF00106.20 KOO33420.1 - 4.9e-10 39.5 3.9 5e-05 23.2 0.0 3.5 3 0 0 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.1 KOO33420.1 - 0.00019 21.3 0.0 0.07 12.8 0.0 2.4 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Spt4 PF06093.8 KOO33420.1 - 0.014 15.2 2.0 0.023 14.5 0.5 2.0 3 0 0 3 3 3 0 Spt4/RpoE2 zinc finger NAD_binding_10 PF13460.1 KOO33420.1 - 0.023 14.7 1.1 0.084 12.8 0.0 2.4 3 0 0 3 3 3 0 NADH(P)-binding Response_reg PF00072.19 KOO33421.1 - 2.4e-16 59.7 0.0 3.6e-16 59.1 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Cupin_2 PF07883.6 KOO33422.1 - 7.6e-07 28.5 0.1 2.8e-06 26.7 0.1 1.9 2 0 0 2 2 2 1 Cupin domain Cupin_6 PF12852.2 KOO33422.1 - 0.0011 18.6 4.3 0.28 10.7 0.1 3.6 2 2 1 3 3 3 2 Cupin AraC_binding PF02311.14 KOO33422.1 - 0.0043 16.7 0.1 0.037 13.7 0.1 2.1 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_3 PF05899.7 KOO33422.1 - 0.057 12.8 0.0 0.38 10.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF861) Ank_2 PF12796.2 KOO33423.1 - 9.8e-17 61.0 0.1 3.7e-16 59.2 0.1 2.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO33423.1 - 3.8e-16 57.9 0.1 5.9e-07 28.9 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.1 KOO33423.1 - 2.8e-13 49.9 0.2 1.2e-07 32.0 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO33423.1 - 2.5e-12 46.5 1.0 2.6e-08 33.8 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO33423.1 - 9e-11 40.9 0.3 0.0018 18.3 0.0 4.6 6 0 0 6 6 6 2 Ankyrin repeat ART PF01129.13 KOO33423.1 - 5.5e-09 35.4 0.4 1.8e-08 33.8 0.0 1.9 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.9 KOO33423.1 - 0.00014 21.1 0.0 0.00029 20.0 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Pex16 PF08610.5 KOO33423.1 - 0.00017 20.7 0.1 0.38 9.7 0.0 2.4 2 0 0 2 2 2 2 Peroxisomal membrane protein (Pex16) LRR_4 PF12799.2 KOO33424.1 - 4.2e-06 26.2 2.2 0.00056 19.4 0.4 2.4 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO33424.1 - 0.00015 21.4 0.6 0.00026 20.6 0.4 1.5 1 0 0 1 1 1 1 Leucine rich repeat LRR_7 PF13504.1 KOO33424.1 - 0.23 11.7 1.8 3.8 8.1 0.2 3.2 3 0 0 3 3 3 0 Leucine rich repeat PWWP PF00855.12 KOO33426.1 - 6.9e-10 38.9 0.6 1.7e-09 37.7 0.4 1.7 1 0 0 1 1 1 1 PWWP domain Shugoshin_C PF07557.6 KOO33426.1 - 0.06 12.8 0.0 0.06 12.8 0.0 2.5 2 0 0 2 2 2 0 Shugoshin C terminus Glyco_trans_1_4 PF13692.1 KOO33427.1 - 3.2e-19 69.4 0.5 2.5e-17 63.2 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glycos_transf_1 PF00534.15 KOO33427.1 - 0.059 12.7 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 KOO33427.1 - 0.13 12.5 0.0 0.25 11.6 0.0 1.6 1 1 0 1 1 1 0 Glycosyl transferases group 1 SPOUT_MTase PF02590.12 KOO33429.1 - 4e-32 111.0 0.0 6.9e-31 107.0 0.0 2.0 1 1 0 1 1 1 1 Predicted SPOUT methyltransferase LRR_4 PF12799.2 KOO33430.1 - 1.5e-17 62.7 11.2 5.7e-05 22.6 1.8 4.5 3 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO33430.1 - 9.8e-13 47.6 34.8 9e-06 25.3 2.6 3.6 1 1 3 4 4 4 4 Leucine rich repeat LRR_9 PF14580.1 KOO33430.1 - 2.7e-06 27.0 2.6 6.2e-06 25.8 1.6 1.7 1 1 1 2 2 2 2 Leucine-rich repeat LRR_7 PF13504.1 KOO33430.1 - 0.0063 16.5 16.8 5.5 7.6 0.0 6.1 4 1 2 6 6 6 2 Leucine rich repeat LRR_6 PF13516.1 KOO33430.1 - 0.014 15.3 17.6 1.7 8.9 0.0 5.5 6 0 0 6 6 6 0 Leucine Rich repeat LRR_1 PF00560.28 KOO33430.1 - 0.033 14.1 19.6 1.7 8.9 0.3 5.7 4 2 1 5 5 5 0 Leucine Rich Repeat Kinesin PF00225.18 KOO33431.1 - 3.8e-68 229.6 0.0 5.4e-68 229.1 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain SAP PF02037.22 KOO33431.1 - 8.3e-06 25.1 0.7 2.1e-05 23.9 0.5 1.7 1 0 0 1 1 1 1 SAP domain AAA_22 PF13401.1 KOO33431.1 - 0.093 12.8 0.7 0.39 10.8 0.0 2.3 3 0 0 3 3 3 0 AAA domain TMF_TATA_bd PF12325.3 KOO33431.1 - 0.29 10.8 8.6 1.4 8.6 2.8 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding SCP-1 PF05483.7 KOO33431.1 - 0.34 8.6 3.8 0.48 8.1 2.6 1.1 1 0 0 1 1 1 0 Synaptonemal complex protein 1 (SCP-1) DUF972 PF06156.8 KOO33431.1 - 0.35 11.2 2.2 1.3 9.4 1.2 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF972) DUF641 PF04859.7 KOO33431.1 - 1.3 8.7 6.5 2.9 7.6 3.2 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Chloroa_b-bind PF00504.16 KOO33432.1 - 1.8e-27 96.5 0.1 2.5e-27 96.0 0.0 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Ank_2 PF12796.2 KOO33433.1 - 2.9e-17 62.7 0.8 1.3e-14 54.3 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO33433.1 - 1.3e-13 50.0 0.2 3.1e-06 26.7 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 KOO33433.1 - 1.6e-13 50.4 1.1 6.7e-12 45.2 0.2 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO33433.1 - 9.3e-12 45.1 0.2 1.4e-07 31.7 0.2 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO33433.1 - 4e-08 32.7 0.0 0.00079 19.4 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat HECT PF00632.20 KOO33434.1 - 1.5e-06 27.6 0.0 2.6e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) HATPase_c_3 PF13589.1 KOO33435.1 - 3.1e-13 49.5 0.0 5.5e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 KOO33435.1 - 1.4e-08 34.3 0.0 2.9e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DEAD PF00270.24 KOO33436.1 - 2.1e-37 128.1 0.0 3.6e-37 127.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO33436.1 - 4.8e-18 64.7 0.0 1.1e-17 63.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO33436.1 - 0.02 14.7 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Gal4_dimer PF03902.8 KOO33436.1 - 0.066 13.1 1.7 3.3 7.7 0.3 2.8 2 0 0 2 2 2 0 Gal4-like dimerisation domain HpcH_HpaI PF03328.9 KOO33437.1 - 4.2e-37 127.1 0.0 5.3e-37 126.8 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PEP_mutase PF13714.1 KOO33437.1 - 0.04 13.1 0.3 0.2 10.8 0.0 2.2 3 0 0 3 3 3 0 Phosphoenolpyruvate phosphomutase TAP42 PF04177.7 KOO33438.1 - 8.3e-48 163.0 4.8 6.2e-47 160.1 3.3 1.9 1 1 0 1 1 1 1 TAP42-like family ELO PF01151.13 KOO33439.1 - 6.1e-64 215.7 8.3 7e-64 215.5 5.7 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family TPR_20 PF14561.1 KOO33440.1 - 0.075 13.1 0.3 0.075 13.1 0.2 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Gly-zipper_OmpA PF13436.1 KOO33441.1 - 0.0012 18.4 1.5 0.0026 17.4 1.0 1.5 1 0 0 1 1 1 1 Glycine-zipper containing OmpA-like membrane domain Gly-zipper_YMGG PF13441.1 KOO33441.1 - 0.0067 15.9 7.0 0.017 14.6 4.9 1.6 1 0 0 1 1 1 1 YMGG-like Gly-zipper Gly-zipper_Omp PF13488.1 KOO33441.1 - 0.013 15.1 5.2 0.028 14.0 3.6 1.5 1 0 0 1 1 1 0 Glycine zipper WD40 PF00400.27 KOO33444.1 - 1.1e-86 281.9 31.9 9.7e-13 47.4 0.5 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat PD40 PF07676.7 KOO33444.1 - 4.8e-20 70.8 6.5 0.26 10.9 0.0 7.4 7 0 0 7 7 7 7 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOO33444.1 - 1.8e-10 40.8 0.4 0.00073 19.3 0.0 3.1 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.1 KOO33444.1 - 3.2e-07 29.7 6.1 1.4 7.9 0.1 5.5 1 1 6 7 7 7 5 Neuroblastoma-amplified sequence, N terminal DUF4467 PF14729.1 KOO33444.1 - 0.023 15.0 0.0 33 4.9 0.0 3.8 2 2 3 5 5 5 0 Domain of unknown function with cystatin-like fold (DUF4467) DUF1476 PF07345.6 KOO33444.1 - 0.058 13.6 0.1 42 4.4 0.0 4.4 2 2 3 5 5 5 0 Domain of unknown function (DUF1476) Dfp1_Him1_M PF08630.5 KOO33444.1 - 0.42 10.4 10.9 15 5.3 0.0 5.2 5 1 1 6 6 6 0 Dfp1/Him1, central region IQ PF00612.22 KOO33446.1 - 0.58 9.9 12.1 0.35 10.6 0.8 3.6 3 0 0 3 3 3 0 IQ calmodulin-binding motif Kelch_6 PF13964.1 KOO33448.1 - 3e-08 33.4 0.0 0.53 10.5 0.0 5.8 6 0 0 6 6 6 3 Kelch motif SGL PF08450.7 KOO33448.1 - 0.00031 20.2 0.0 1.2 8.4 0.0 4.0 2 1 1 3 3 3 2 SMP-30/Gluconolaconase/LRE-like region Ribosomal_L11_N PF03946.9 KOO33448.1 - 0.0025 17.2 24.3 8.3 5.9 0.1 7.2 7 0 0 7 7 7 4 Ribosomal protein L11, N-terminal domain ExbD PF02472.11 KOO33449.1 - 0.052 13.5 0.1 0.059 13.3 0.0 1.1 1 0 0 1 1 1 0 Biopolymer transport protein ExbD/TolR DUF2853 PF11015.3 KOO33449.1 - 0.11 12.9 0.3 0.16 12.4 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2853) Dpy-30 PF05186.8 KOO33451.1 - 1.5e-17 62.7 0.1 1.9e-17 62.4 0.1 1.1 1 0 0 1 1 1 1 Dpy-30 motif RIIa PF02197.12 KOO33451.1 - 0.0028 17.0 0.1 0.0055 16.1 0.1 1.4 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Myb_DNA-binding PF00249.26 KOO33452.1 - 0.047 13.7 0.2 0.12 12.5 0.1 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain PHP_C PF13263.1 KOO33452.1 - 0.052 13.0 0.0 0.1 12.0 0.0 1.5 1 0 0 1 1 1 0 PHP-associated IL34 PF15036.1 KOO33452.1 - 0.074 12.6 0.1 0.21 11.1 0.0 1.7 2 0 0 2 2 2 0 Interleukin 34 ABC1 PF03109.11 KOO33453.1 - 1.2e-23 83.3 0.0 2.7e-23 82.1 0.0 1.6 1 1 0 1 1 1 1 ABC1 family APH PF01636.18 KOO33453.1 - 1.4e-05 24.9 0.3 4e-05 23.4 0.2 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 KOO33453.1 - 0.023 14.0 0.0 0.17 11.1 0.0 2.0 2 0 0 2 2 2 0 RIO1 family Pkinase PF00069.20 KOO33453.1 - 0.17 10.9 0.0 1.4 8.0 0.0 2.0 2 0 0 2 2 2 0 Protein kinase domain Galactosyl_T PF01762.16 KOO33454.1 - 6.2e-08 32.4 0.0 1.5e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Galactosyltransferase PAN_1 PF00024.21 KOO33454.1 - 0.00091 18.9 2.1 0.00091 18.9 1.4 1.9 2 0 0 2 2 2 1 PAN domain DUF2527 PF10736.4 KOO33454.1 - 0.03 13.9 2.1 0.36 10.4 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) Glycolytic PF00274.14 KOO33456.1 - 3.8e-113 377.4 0.0 5e-113 377.0 0.0 1.1 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I Ank_2 PF12796.2 KOO33456.1 - 1.4e-14 54.1 0.1 5.3e-14 52.3 0.1 1.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO33456.1 - 3.3e-14 51.8 2.0 7.5e-06 25.5 0.2 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 KOO33456.1 - 2.2e-09 37.2 4.0 7.5e-06 26.0 0.3 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO33456.1 - 2.2e-08 33.5 1.4 0.011 15.8 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOO33456.1 - 6.2e-08 32.9 1.6 3.2e-06 27.5 0.1 3.2 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Myb_DNA-binding PF00249.26 KOO33457.1 - 1.1e-27 95.7 0.4 1.1e-14 54.1 0.1 2.6 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO33457.1 - 3.8e-21 74.9 0.0 7.2e-15 54.8 0.0 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.5 KOO33457.1 - 0.099 12.3 0.0 1.5 8.5 0.0 2.2 1 1 1 2 2 2 0 SLIDE Myb_DNA-bind_4 PF13837.1 KOO33457.1 - 0.15 12.2 2.3 8.9 6.5 0.3 2.8 1 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain NTP_transferase PF00483.18 KOO33458.1 - 2.6e-34 118.6 0.0 3.5e-34 118.2 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 KOO33458.1 - 1.4e-11 44.6 0.0 2e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.19 KOO33458.1 - 4.9e-09 35.2 11.7 9.1e-08 31.2 1.2 4.0 2 1 3 5 5 5 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 KOO33458.1 - 0.007 15.9 1.7 0.007 15.9 1.2 2.5 2 0 0 2 2 2 1 Hexapeptide repeat of succinyl-transferase WD40 PF00400.27 KOO33459.1 - 1.4e-11 43.7 10.5 0.00025 20.8 0.0 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat YmzC PF14157.1 KOO33459.1 - 0.058 13.2 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 YmzC-like protein SRP54 PF00448.17 KOO33460.1 - 0.027 13.9 0.4 0.071 12.5 0.1 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_16 PF13191.1 KOO33460.1 - 0.044 13.7 0.1 0.12 12.4 0.1 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_19 PF13245.1 KOO33460.1 - 5.1 6.9 6.1 0.89 9.3 0.1 2.7 3 0 0 3 3 3 0 Part of AAA domain Mito_carr PF00153.22 KOO33461.1 - 2.8e-18 65.4 12.8 1.1e-07 31.4 0.2 3.4 2 1 1 3 3 3 3 Mitochondrial carrier protein Dynein_heavy PF03028.10 KOO33462.1 - 4.9e-225 748.7 0.0 7.7e-225 748.1 0.0 1.3 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor MT PF12777.2 KOO33462.1 - 2.1e-77 260.2 3.1 4e-46 157.3 0.1 2.5 2 0 0 2 2 2 2 Microtubule-binding stalk of dynein motor AAA_9 PF12781.2 KOO33462.1 - 2.7e-59 199.8 0.9 7.8e-59 198.2 0.1 2.2 2 1 0 2 2 2 1 ATP-binding dynein motor region D5 Tropomyosin_1 PF12718.2 KOO33462.1 - 0.067 13.0 3.4 0.16 11.8 2.3 1.6 1 0 0 1 1 1 0 Tropomyosin like CENP-F_leu_zip PF10473.4 KOO33462.1 - 0.23 11.3 2.1 0.73 9.6 1.4 1.8 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_27 PF13514.1 KOO33462.1 - 0.76 7.3 7.2 1 6.9 2.5 2.1 2 0 0 2 2 2 0 AAA domain PABP PF00658.13 KOO33463.1 - 2.7e-06 26.9 0.2 6.9e-06 25.6 0.1 1.7 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain Methyltransf_21 PF05050.7 KOO33464.1 - 1.7e-14 54.1 0.0 2.2e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_18 PF12847.2 KOO33464.1 - 6e-05 23.6 0.0 8.4e-05 23.1 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO33464.1 - 0.0017 18.0 0.0 0.0019 17.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ank_2 PF12796.2 KOO33465.1 - 4e-18 65.5 1.7 1.3e-17 63.9 1.2 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO33465.1 - 1.3e-16 59.4 0.3 8.2e-07 28.5 0.1 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.1 KOO33465.1 - 8.4e-14 51.2 1.5 3.2e-09 36.7 0.2 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO33465.1 - 4.2e-13 49.4 0.3 1.7e-06 28.3 0.1 3.0 3 0 0 3 3 3 2 Ankyrin repeats (many copies) EF-hand_7 PF13499.1 KOO33465.1 - 2.2e-12 46.9 0.6 5.2e-09 36.1 0.1 2.2 1 1 1 2 2 2 2 EF-hand domain pair Ank_3 PF13606.1 KOO33465.1 - 4.5e-12 44.9 1.1 0.00019 21.3 0.0 4.1 4 0 0 4 4 3 2 Ankyrin repeat EF-hand_1 PF00036.27 KOO33465.1 - 1.2e-11 43.0 0.2 4e-05 22.6 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO33465.1 - 2.2e-11 42.6 0.4 0.00036 20.1 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO33465.1 - 1.1e-09 37.8 0.1 7.9e-07 28.5 0.0 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO33465.1 - 1.5e-08 33.6 1.8 5e-05 22.4 0.2 2.6 2 0 0 2 2 2 2 EF hand ADPrib_exo_Tox PF03496.9 KOO33465.1 - 1.7e-05 24.1 0.0 7.2e-05 22.0 0.0 2.0 2 0 0 2 2 2 1 ADP-ribosyltransferase exoenzyme ART PF01129.13 KOO33465.1 - 0.0024 17.0 0.0 0.0058 15.7 0.0 1.6 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase LRR_6 PF13516.1 KOO33466.1 - 1e-33 111.5 57.1 0.019 14.9 0.3 22.9 23 0 0 23 23 23 12 Leucine Rich repeat LRR_4 PF12799.2 KOO33466.1 - 1.4e-11 43.7 41.5 0.066 12.8 0.0 13.7 11 3 1 13 13 13 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO33466.1 - 2.1e-08 33.0 21.2 23 5.5 0.2 14.5 17 0 0 17 17 17 0 Leucine Rich Repeat SpoU_sub_bind PF08032.7 KOO33466.1 - 0.00038 20.5 1.4 18 5.5 0.0 6.8 7 0 0 7 7 7 1 RNA 2'-O ribose methyltransferase substrate binding AAA_25 PF13481.1 KOO33466.1 - 0.0044 16.4 1.2 0.062 12.6 0.0 2.7 3 0 0 3 3 3 1 AAA domain LRR_8 PF13855.1 KOO33466.1 - 0.15 11.8 43.7 7.3 6.4 0.0 13.5 11 4 5 16 16 16 0 Leucine rich repeat DUF2202 PF09968.4 KOO33466.1 - 7.4 6.2 11.0 82 2.8 0.1 5.7 5 1 1 6 6 6 0 Uncharacterized protein domain (DUF2202) SNF2_N PF00176.18 KOO33468.1 - 9.5e-12 44.3 0.0 1.4e-11 43.7 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain DNA_methylase PF00145.12 KOO33468.1 - 1.4e-06 27.6 0.0 0.041 13.0 0.0 2.4 2 1 0 2 2 2 2 C-5 cytosine-specific DNA methylase FYVE_2 PF02318.11 KOO33468.1 - 8 6.3 9.8 16 5.4 6.8 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger DUF3633 PF12315.3 KOO33469.1 - 0.15 11.3 0.5 0.2 10.9 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3633) FKBP_N PF01346.13 KOO33469.1 - 0.22 11.5 4.2 0.34 10.9 1.9 1.8 1 1 1 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase PDZ PF00595.19 KOO33470.1 - 1.1e-16 60.7 1.5 4.6e-07 29.9 0.0 2.5 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO33470.1 - 5.7e-16 58.1 2.1 2.4e-07 30.5 0.1 2.5 2 0 0 2 2 2 2 PDZ domain FAIM1 PF06905.8 KOO33470.1 - 1.4e-06 27.6 0.0 2.4e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Fas apoptotic inhibitory molecule (FAIM1) Tricorn_PDZ PF14685.1 KOO33470.1 - 0.0035 17.0 0.4 4.5 7.1 0.0 3.2 3 0 0 3 3 3 2 Tricorn protease PDZ domain TMCO5 PF14992.1 KOO33471.1 - 0.14 11.2 1.1 0.26 10.3 0.7 1.4 1 0 0 1 1 1 0 TMCO5 family IFT57 PF10498.4 KOO33471.1 - 0.18 10.4 1.1 0.28 9.8 0.8 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 BLOC1_2 PF10046.4 KOO33471.1 - 0.23 11.6 2.3 0.37 10.9 0.9 1.9 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Enkurin PF13864.1 KOO33471.1 - 5.5 7.2 10.6 1.2 9.3 1.5 3.5 3 1 0 3 3 3 0 Calmodulin-binding Nol1_Nop2_Fmu PF01189.12 KOO33472.1 - 3.8e-20 72.4 0.0 1.8e-11 43.9 0.0 2.7 1 1 1 2 2 2 2 NOL1/NOP2/sun family FtsJ PF01728.14 KOO33472.1 - 0.0014 18.6 0.0 0.0023 17.9 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase NAD_binding_8 PF13450.1 KOO33474.1 - 3.5e-12 46.1 0.1 9.4e-12 44.7 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 KOO33474.1 - 5.8e-10 38.8 0.2 0.00016 20.9 0.0 2.7 2 1 0 2 2 2 2 Flavin containing amine oxidoreductase DAO PF01266.19 KOO33474.1 - 6.3e-09 35.2 0.3 0.002 17.0 0.1 2.5 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 KOO33474.1 - 5.9e-08 31.9 0.6 4.4e-05 22.5 0.2 2.2 2 0 0 2 2 2 2 FAD binding domain GDI PF00996.13 KOO33474.1 - 7.1e-08 31.1 0.4 0.0011 17.3 0.0 2.1 2 0 0 2 2 2 2 GDP dissociation inhibitor Thi4 PF01946.12 KOO33474.1 - 6.7e-05 22.0 0.2 0.00014 21.0 0.1 1.4 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.9 KOO33474.1 - 0.00029 19.4 0.6 0.027 12.9 0.2 2.3 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.9 KOO33474.1 - 0.0019 18.1 0.1 0.038 13.8 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GMC_oxred_N PF00732.14 KOO33474.1 - 0.008 15.3 0.1 0.027 13.6 0.0 1.8 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_3 PF01494.14 KOO33474.1 - 0.0096 15.0 0.4 0.016 14.3 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 KOO33474.1 - 0.013 14.6 0.7 0.04 13.0 0.1 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox PF00070.22 KOO33474.1 - 0.016 15.6 2.6 0.72 10.2 0.1 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 KOO33474.1 - 0.031 13.2 0.1 1.1 8.1 0.0 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein GIDA PF01134.17 KOO33474.1 - 0.034 13.0 0.3 1.8 7.3 0.1 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A UPF0227 PF05728.7 KOO33474.1 - 0.055 13.1 0.0 0.21 11.2 0.0 1.9 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) zf-RanBP PF00641.13 KOO33476.1 - 4.9e-05 22.3 1.5 9.4e-05 21.4 1.0 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others AP2 PF00847.15 KOO33476.1 - 0.00043 20.3 3.7 0.95 9.6 0.2 3.7 3 0 0 3 3 3 2 AP2 domain Peptidase_S49 PF01343.13 KOO33477.1 - 1e-30 106.5 0.0 1.9e-30 105.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S49 Peptidase_S49_N PF08496.5 KOO33477.1 - 7.3e-14 51.8 0.1 3.9e-13 49.4 0.1 2.0 1 1 0 1 1 1 1 Peptidase family S49 N-terminal SDH_sah PF01972.11 KOO33477.1 - 0.0018 17.0 0.2 0.0028 16.4 0.1 1.2 1 0 0 1 1 1 1 Serine dehydrogenase proteinase CLP_protease PF00574.18 KOO33477.1 - 0.016 14.8 0.1 0.061 12.9 0.1 1.8 1 1 1 2 2 2 0 Clp protease RmlD_sub_bind PF04321.12 KOO33478.1 - 3.8e-58 196.6 0.0 4.6e-58 196.3 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.16 KOO33478.1 - 8.9e-14 51.4 0.0 1.2e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 KOO33478.1 - 0.0014 17.5 0.1 0.58 8.9 0.0 2.3 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein GST_N PF02798.15 KOO33479.1 - 8e-16 57.9 0.0 1.5e-15 57.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KOO33479.1 - 2.2e-05 24.2 2.1 3.2e-05 23.7 0.2 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 KOO33479.1 - 8.7e-05 22.9 0.0 0.0003 21.2 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 KOO33479.1 - 0.00034 20.7 0.0 0.00071 19.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Translat_reg PF01818.12 KOO33479.1 - 0.06 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage translational regulator Ion_trans_2 PF07885.11 KOO33481.1 - 2.5e-06 27.1 1.5 2.5e-06 27.1 1.1 2.1 2 0 0 2 2 2 1 Ion channel DUF4282 PF14110.1 KOO33481.1 - 1.7 8.8 10.3 2 8.6 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4282) Nuc_sug_transp PF04142.10 KOO33482.1 - 6e-08 32.0 4.7 2.7e-07 29.9 3.3 1.9 1 1 0 1 1 1 1 Nucleotide-sugar transporter TPT PF03151.11 KOO33482.1 - 0.00023 20.8 6.8 0.00023 20.8 4.7 3.1 2 2 0 2 2 2 1 Triose-phosphate Transporter family EmrE PF13536.1 KOO33482.1 - 0.00036 20.7 7.8 0.00036 20.7 5.4 3.7 4 2 1 5 5 5 1 Multidrug resistance efflux transporter Mnd1 PF03962.10 KOO33483.1 - 0.066 12.8 1.8 0.13 11.9 1.0 1.7 2 0 0 2 2 2 0 Mnd1 family FAD_binding_9 PF08021.6 KOO33483.1 - 0.18 11.7 1.3 0.42 10.5 0.2 2.0 2 0 0 2 2 2 0 Siderophore-interacting FAD-binding domain zf-HYPF PF07503.7 KOO33485.1 - 0.091 12.1 0.0 0.22 10.9 0.0 1.6 1 0 0 1 1 1 0 HypF finger WD40 PF00400.27 KOO33486.1 - 1.1e-24 85.2 4.7 1.2e-08 34.4 0.6 6.5 6 1 0 6 6 6 5 WD domain, G-beta repeat EF-hand_7 PF13499.1 KOO33488.1 - 0.00024 21.1 0.2 0.00068 19.7 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO33488.1 - 0.00028 20.5 0.2 0.0043 16.8 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 KOO33488.1 - 0.0023 17.1 0.1 0.021 14.1 0.0 2.3 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.1 KOO33488.1 - 0.11 11.9 0.0 0.26 10.7 0.0 1.7 1 0 0 1 1 1 0 EF hand Stn1 PF10451.4 KOO33489.1 - 2.2e-05 23.4 0.0 3.2e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Telomere regulation protein Stn1 tRNA_anti-codon PF01336.20 KOO33489.1 - 0.0027 17.5 0.0 0.005 16.6 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain PDEase_I PF00233.14 KOO33490.1 - 6.8e-13 48.9 0.0 8.4e-13 48.6 0.0 1.1 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Melibiase PF02065.13 KOO33491.1 - 8.2e-15 54.3 0.0 3.4e-12 45.7 0.0 2.2 2 0 0 2 2 2 2 Melibiase Glyco_hydro_97 PF10566.4 KOO33491.1 - 0.0031 16.6 0.0 0.0045 16.1 0.0 1.2 1 0 0 1 1 1 1 Glycoside hydrolase 97 EF-hand_6 PF13405.1 KOO33492.1 - 1.1e-11 43.5 2.4 0.00013 21.5 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO33492.1 - 8.9e-11 41.7 0.3 1.4e-10 41.1 0.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO33492.1 - 9.8e-10 37.0 2.8 0.00053 19.0 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO33492.1 - 8.2e-09 34.9 0.3 2.6e-08 33.3 0.1 2.0 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO33492.1 - 4.2e-06 25.8 2.5 0.05 12.9 0.1 2.4 2 0 0 2 2 2 2 EF hand IQ PF00612.22 KOO33492.1 - 1.5e-05 24.2 6.2 0.046 13.3 2.0 2.7 2 0 0 2 2 2 2 IQ calmodulin-binding motif Mpp10 PF04006.7 KOO33495.1 - 3.3e-60 204.1 25.7 6e-60 203.2 17.8 1.4 1 1 0 1 1 1 1 Mpp10 protein Metallophos PF00149.23 KOO33496.1 - 2.2e-36 125.1 0.4 3e-36 124.6 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_11 PF13414.1 KOO33496.1 - 4.7e-20 70.9 8.1 1.8e-13 49.9 0.4 3.0 2 1 1 3 3 3 2 TPR repeat PPP5 PF08321.7 KOO33496.1 - 1.1e-19 70.2 0.0 7.8e-18 64.2 0.0 2.3 2 0 0 2 2 2 1 PPP5 TPR repeat region TPR_1 PF00515.23 KOO33496.1 - 5.6e-17 60.5 7.2 8.1e-08 31.5 0.3 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO33496.1 - 2.3e-15 55.1 6.3 5.1e-07 29.1 0.3 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO33496.1 - 6.1e-09 35.3 1.8 0.0017 18.4 0.1 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO33496.1 - 1.3e-07 31.3 0.4 0.00059 19.6 0.1 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO33496.1 - 4.7e-07 30.3 1.1 0.032 14.9 0.0 2.7 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOO33496.1 - 7.1e-07 29.3 1.0 0.008 16.7 0.2 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO33496.1 - 8.2e-07 28.3 4.3 0.0003 20.3 0.3 3.8 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOO33496.1 - 8.3e-05 22.4 1.1 0.33 10.9 0.1 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat Apc3 PF12895.2 KOO33496.1 - 0.00075 19.5 1.4 0.0015 18.5 1.0 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 KOO33496.1 - 0.001 18.7 0.6 1.6 8.7 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO33496.1 - 0.0016 18.7 0.4 0.75 10.1 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.1 KOO33496.1 - 0.017 15.5 0.5 0.29 11.6 0.3 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Paf67 PF10255.4 KOO33496.1 - 0.089 11.6 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase I-associated factor PAF67 DAGK_cat PF00781.19 KOO33498.1 - 0.00067 19.1 0.0 0.007 15.7 0.0 2.4 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.16 KOO33498.1 - 0.00099 17.9 0.0 0.0015 17.3 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase PilJ PF13675.1 KOO33498.1 - 0.028 14.7 2.2 0.057 13.7 1.6 1.6 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term CENP-F_leu_zip PF10473.4 KOO33498.1 - 0.036 13.9 1.1 0.059 13.2 0.8 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4164 PF13747.1 KOO33498.1 - 0.037 14.1 3.8 0.07 13.2 2.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Pkinase PF00069.20 KOO33499.1 - 2.7e-49 167.6 0.0 4e-49 167.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33499.1 - 1.4e-41 142.3 0.0 1.8e-41 141.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO33499.1 - 0.16 11.6 0.3 0.38 10.4 0.2 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-H2C2_2 PF13465.1 KOO33500.1 - 6.2e-36 120.9 59.3 2.4e-07 30.6 0.9 7.4 8 0 0 8 8 8 6 Zinc-finger double domain zf-C2H2 PF00096.21 KOO33500.1 - 1.4e-30 103.7 57.9 5.1e-05 23.3 1.8 7.1 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOO33500.1 - 2e-25 87.2 51.0 7e-05 22.8 1.0 7.2 7 0 0 7 7 7 7 C2H2-type zinc finger zf-C2H2_6 PF13912.1 KOO33500.1 - 2.9e-07 30.1 29.5 1 9.3 0.3 7.2 7 1 0 7 7 7 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KOO33500.1 - 2.6e-05 24.2 36.6 0.21 11.7 0.8 7.4 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding CHORD PF04968.7 KOO33500.1 - 0.00074 19.7 44.0 2.9 8.1 0.9 7.1 2 2 5 7 7 7 6 CHORD zf-met PF12874.2 KOO33500.1 - 0.00089 19.3 17.4 4.3 7.6 0.1 6.4 6 0 0 6 6 6 3 Zinc-finger of C2H2 type Arm PF00514.18 KOO33500.1 - 0.076 12.8 0.2 0.076 12.8 0.1 1.8 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Ogr_Delta PF04606.7 KOO33500.1 - 1.4 8.6 24.5 3.3 7.4 0.3 6.4 2 1 5 7 7 7 0 Ogr/Delta-like zinc finger NUMOD3 PF07460.6 KOO33501.1 - 1.9 8.4 6.2 0.57 10.1 0.7 2.9 3 0 0 3 3 3 0 NUMOD3 motif (2 copies) PRTase_3 PF15610.1 KOO33502.1 - 2.7e-09 36.3 0.0 4.5e-09 35.6 0.0 1.3 2 0 0 2 2 2 1 PRTase ComF-like SNARE PF05739.14 KOO33503.1 - 2.7e-14 52.5 3.5 2.7e-14 52.5 2.4 2.1 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.1 KOO33503.1 - 1.6e-11 44.1 5.8 1.7e-10 40.8 0.1 2.2 1 1 1 2 2 2 1 Syntaxin-like protein MCPsignal PF00015.16 KOO33503.1 - 8.9e-06 25.4 4.2 1.2e-05 24.9 2.9 1.2 1 0 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain Laminin_II PF06009.7 KOO33503.1 - 0.00029 20.5 6.0 0.0003 20.5 1.8 2.1 2 0 0 2 2 2 1 Laminin Domain II Allexi_40kDa PF05549.6 KOO33503.1 - 0.00036 19.9 0.6 0.00048 19.5 0.4 1.1 1 0 0 1 1 1 1 Allexivirus 40kDa protein TMP_2 PF06791.8 KOO33503.1 - 0.0015 18.2 2.0 0.34 10.5 1.0 2.1 1 1 1 2 2 2 2 Prophage tail length tape measure protein Mnd1 PF03962.10 KOO33503.1 - 0.0017 18.0 7.3 0.0023 17.6 5.1 1.1 1 0 0 1 1 1 1 Mnd1 family IFT57 PF10498.4 KOO33503.1 - 0.003 16.3 3.4 0.0036 16.1 2.4 1.1 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Ax_dynein_light PF10211.4 KOO33503.1 - 0.0096 15.7 9.4 0.014 15.2 6.5 1.2 1 0 0 1 1 1 1 Axonemal dynein light chain DUF812 PF05667.6 KOO33503.1 - 0.0098 14.4 5.8 0.013 14.1 4.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) RE_TdeIII PF09520.5 KOO33503.1 - 0.01 15.1 1.8 0.014 14.7 1.3 1.1 1 0 0 1 1 1 0 Type II restriction endonuclease, TdeIII DUF2605 PF10792.4 KOO33503.1 - 0.035 13.7 1.0 0.063 12.9 0.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2605) Med28 PF11594.3 KOO33503.1 - 0.071 13.3 1.3 0.14 12.3 0.9 1.5 1 1 0 1 1 1 0 Mediator complex subunit 28 HrpB2 PF09487.5 KOO33503.1 - 0.092 12.9 2.9 0.15 12.2 1.6 1.6 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB2) DUF2458 PF10454.4 KOO33503.1 - 0.13 12.1 3.0 0.19 11.6 2.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) DUF948 PF06103.6 KOO33503.1 - 0.4 10.5 2.7 1.3 8.9 0.8 2.5 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF3708 PF12501.3 KOO33503.1 - 0.46 10.2 4.1 2 8.2 0.3 2.0 1 1 1 2 2 2 0 Phosphate ATP-binding cassette transporter DUF1117 PF06547.7 KOO33503.1 - 0.5 10.4 2.7 1.5 8.8 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1117) DUF883 PF05957.8 KOO33503.1 - 0.55 10.6 7.5 2.7 8.4 0.8 2.4 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF148 PF02520.12 KOO33503.1 - 0.59 9.9 6.0 0.78 9.5 3.4 1.6 1 1 1 2 2 2 0 Domain of unknown function DUF148 DUF349 PF03993.7 KOO33503.1 - 1 9.5 5.6 3.8 7.7 0.4 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) THOC7 PF05615.8 KOO33503.1 - 1.1 9.5 7.7 2.1 8.6 5.3 1.5 1 1 0 1 1 1 0 Tho complex subunit 7 FUSC PF04632.7 KOO33503.1 - 1.2 7.5 5.2 0.32 9.3 1.5 1.4 1 1 0 1 1 1 0 Fusaric acid resistance protein family DUF745 PF05335.8 KOO33503.1 - 1.3 8.4 9.6 2.2 7.7 6.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Synaptobrevin PF00957.16 KOO33503.1 - 2.3 7.8 5.7 3 7.4 2.5 2.4 1 1 1 2 2 2 0 Synaptobrevin KxDL PF10241.4 KOO33503.1 - 6.2 6.8 9.7 2.5 8.0 2.8 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein PNTB PF02233.11 KOO33504.1 - 1.1e-173 578.2 15.5 1.1e-173 578.2 10.7 2.0 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.16 KOO33504.1 - 3.2e-51 173.2 1.1 8.7e-51 171.8 0.8 1.8 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.10 KOO33504.1 - 1.8e-33 115.4 0.0 4e-33 114.2 0.0 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain DUF3814 PF12769.2 KOO33504.1 - 1.8e-29 101.7 5.8 1.8e-29 101.7 4.0 4.1 4 0 0 4 4 4 1 Domain of unknown function (DUF3814) ParA PF10609.4 KOO33504.1 - 3.9e-29 100.3 0.0 9.3e-29 99.1 0.0 1.6 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 KOO33504.1 - 4.2e-08 32.8 0.0 8.2e-08 31.8 0.0 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ADH_zinc_N PF00107.21 KOO33504.1 - 0.0019 17.7 4.1 0.0047 16.4 0.3 3.3 3 0 0 3 3 3 1 Zinc-binding dehydrogenase GIDA PF01134.17 KOO33504.1 - 0.019 13.8 0.9 0.042 12.7 0.6 1.6 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox_2 PF07992.9 KOO33504.1 - 0.041 13.7 0.1 0.12 12.2 0.1 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.14 KOO33504.1 - 0.052 12.7 0.3 1.5 7.9 0.1 2.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.22 KOO33504.1 - 0.069 13.5 3.5 0.33 11.4 0.4 3.2 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase WD40 PF00400.27 KOO33505.1 - 4.6e-51 168.9 23.1 1.6e-08 34.0 0.6 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 KOO33505.1 - 9.5e-06 25.4 0.9 0.17 11.5 0.0 3.2 3 2 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A LRR_6 PF13516.1 KOO33506.1 - 1.2e-13 49.5 12.1 0.00085 19.1 0.1 7.5 7 0 0 7 7 7 3 Leucine Rich repeat LRR_1 PF00560.28 KOO33506.1 - 6.2e-13 46.8 0.1 1.9 8.8 0.0 6.3 6 0 0 6 6 6 4 Leucine Rich Repeat LRR_4 PF12799.2 KOO33506.1 - 4.3e-08 32.6 3.7 0.7 9.5 0.4 5.4 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO33506.1 - 1.2e-06 28.2 0.6 8.1 6.2 0.7 5.2 4 1 0 4 4 4 2 Leucine rich repeat LRR_7 PF13504.1 KOO33506.1 - 3.4e-06 26.3 5.1 4.6 7.8 0.0 5.9 6 0 0 6 6 6 2 Leucine rich repeat UPF0181 PF03701.9 KOO33506.1 - 0.042 13.1 0.3 32 3.9 0.0 3.5 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0181) DUF902 PF06001.8 KOO33506.1 - 0.38 10.9 2.0 44 4.3 0.0 3.7 5 0 0 5 5 5 0 Domain of Unknown Function (DUF902) PCP PF02429.10 KOO33506.1 - 0.49 10.4 5.6 14 5.7 0.0 4.1 2 1 2 5 5 5 0 Peridinin-chlorophyll A binding protein Toxin_40 PF15520.1 KOO33506.1 - 0.91 8.9 7.5 1.5 8.2 0.4 3.0 3 0 0 3 3 3 0 Putative toxin 40 Skp1 PF01466.14 KOO33507.1 - 1.1e-06 28.5 0.0 2.6e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Skp1 family, dimerisation domain LRR_6 PF13516.1 KOO33507.1 - 0.012 15.5 0.1 0.083 13.0 0.0 2.4 2 0 0 2 2 2 0 Leucine Rich repeat Ank_2 PF12796.2 KOO33508.1 - 1e-26 93.0 0.1 1e-10 41.8 0.0 4.4 3 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 KOO33508.1 - 8.2e-24 82.1 5.5 1.9e-06 27.4 0.0 6.5 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.1 KOO33508.1 - 3.5e-20 70.0 0.9 0.00014 21.7 0.0 6.4 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.1 KOO33508.1 - 1.2e-19 69.8 5.6 6.4e-06 26.2 0.0 6.0 4 1 2 6 6 6 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO33508.1 - 2.1e-14 53.5 1.0 3.7e-06 27.2 0.0 5.1 5 0 0 5 5 5 2 Ankyrin repeats (many copies) ParG PF09274.5 KOO33508.1 - 0.088 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 ParG LRR_6 PF13516.1 KOO33509.1 - 6.1e-13 47.3 0.0 0.00025 20.7 0.0 3.4 3 0 0 3 3 3 2 Leucine Rich repeat LRR_4 PF12799.2 KOO33509.1 - 0.004 16.7 0.2 0.054 13.1 0.0 2.6 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO33509.1 - 0.009 15.9 0.0 11 6.5 0.0 3.3 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_7 PF13504.1 KOO33509.1 - 0.011 15.7 0.0 37 5.1 0.0 3.5 3 0 0 3 3 3 0 Leucine rich repeat LRR_8 PF13855.1 KOO33509.1 - 0.13 11.9 0.1 1.3 8.8 0.0 2.4 1 1 2 3 3 2 0 Leucine rich repeat TMF_DNA_bd PF12329.3 KOO33510.1 - 0.095 12.5 2.1 0.28 11.0 0.1 2.3 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF3431 PF11913.3 KOO33511.1 - 7.4e-07 28.8 0.0 0.00064 19.2 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3431) BSD PF03909.12 KOO33512.1 - 1.2e-07 31.3 0.1 2.3e-07 30.4 0.1 1.4 1 0 0 1 1 1 1 BSD domain TFIIH_BTF_p62_N PF08567.6 KOO33512.1 - 3.8e-06 26.4 0.0 5.9e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain UbiA PF01040.13 KOO33513.1 - 3.3e-33 114.9 25.7 4.4e-33 114.5 17.8 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Cation_efflux PF01545.16 KOO33515.1 - 0.00091 18.3 5.1 0.0013 17.8 3.6 1.3 1 1 0 1 1 1 1 Cation efflux family A2M_N_2 PF07703.9 KOO33515.1 - 0.049 13.4 0.1 0.069 12.9 0.1 1.2 1 0 0 1 1 1 0 Alpha-2-macroglobulin family N-terminal region TrbL PF04610.9 KOO33515.1 - 0.057 13.1 2.2 0.089 12.4 1.5 1.3 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein OPA3 PF07047.7 KOO33515.1 - 0.097 12.4 0.5 0.14 11.9 0.3 1.3 1 1 0 1 1 1 0 Optic atrophy 3 protein (OPA3) Glyco_hydro_18 PF00704.23 KOO33516.1 - 5.5e-28 98.4 0.0 9.1e-28 97.6 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 SNF2_N PF00176.18 KOO33517.1 - 1.9e-37 128.6 9.6 2.1e-27 95.6 0.0 3.4 2 1 1 3 3 3 2 SNF2 family N-terminal domain Helicase_C PF00271.26 KOO33517.1 - 3.3e-15 55.6 0.0 1.1e-14 54.0 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain PHD PF00628.24 KOO33517.1 - 1.1e-05 25.0 6.7 1.1e-05 25.0 4.6 3.1 3 0 0 3 3 3 1 PHD-finger AAA_22 PF13401.1 KOO33517.1 - 0.00051 20.1 0.5 0.0056 16.8 0.0 2.7 3 0 0 3 3 3 1 AAA domain ResIII PF04851.10 KOO33517.1 - 0.0012 18.6 3.6 0.0048 16.7 0.0 3.2 3 2 1 4 4 4 1 Type III restriction enzyme, res subunit TPR_12 PF13424.1 KOO33518.1 - 1.3e-67 223.6 36.1 6.9e-17 61.1 0.1 7.6 4 1 4 8 8 8 6 Tetratricopeptide repeat TPR_10 PF13374.1 KOO33518.1 - 6e-61 200.7 44.3 1.3e-10 40.8 0.2 10.2 10 0 0 10 10 9 9 Tetratricopeptide repeat TPR_1 PF00515.23 KOO33518.1 - 4.4e-19 67.2 17.3 0.012 15.1 0.0 7.7 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.12 KOO33518.1 - 4.5e-17 60.5 22.2 0.017 15.0 0.1 8.9 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.1 KOO33518.1 - 3.5e-14 51.4 5.6 0.26 11.1 0.0 7.7 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_11 PF13414.1 KOO33518.1 - 4.4e-13 48.6 12.7 0.0013 18.3 0.2 5.2 1 1 5 6 6 6 6 TPR repeat TPR_4 PF07721.9 KOO33518.1 - 2e-12 46.2 38.0 0.019 15.3 0.2 10.4 10 0 0 10 10 8 5 Tetratricopeptide repeat TPR_17 PF13431.1 KOO33518.1 - 1.7e-11 43.3 9.4 1.6 9.1 0.0 8.4 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_16 PF13432.1 KOO33518.1 - 2.6e-10 40.6 45.5 0.00012 22.6 0.5 8.3 4 1 5 9 9 8 5 Tetratricopeptide repeat TPR_7 PF13176.1 KOO33518.1 - 1.7e-09 36.7 25.4 0.015 15.0 0.1 7.5 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_19 PF14559.1 KOO33518.1 - 1.2e-08 35.1 16.8 0.086 13.1 0.1 6.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_3 PF07720.7 KOO33518.1 - 6.6e-07 28.9 0.1 0.098 12.4 0.0 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat Osmo_CC PF08946.5 KOO33518.1 - 4.1e-06 26.7 1.0 0.8 9.7 0.0 5.4 5 0 0 5 5 5 1 Osmosensory transporter coiled coil Apc3 PF12895.2 KOO33518.1 - 0.00083 19.4 1.8 0.78 9.9 0.0 4.6 2 1 3 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 V-SNARE_C PF12352.3 KOO33518.1 - 0.03 14.4 0.1 2.9 8.0 0.0 3.0 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus TPR_14 PF13428.1 KOO33518.1 - 0.036 14.6 42.7 0.88 10.3 0.1 10.5 11 0 0 11 11 8 0 Tetratricopeptide repeat ApoLp-III PF07464.6 KOO33518.1 - 0.086 12.8 0.5 5.6 6.9 0.0 3.2 2 1 2 4 4 4 0 Apolipophorin-III precursor (apoLp-III) PPR PF01535.15 KOO33518.1 - 0.18 11.8 7.6 28 4.9 0.0 5.7 7 0 0 7 7 6 0 PPR repeat Sec16_C PF12931.2 KOO33518.1 - 0.2 11.3 0.6 18 4.9 0.1 3.5 1 1 1 3 3 3 0 Sec23-binding domain of Sec16 RRM_6 PF14259.1 KOO33521.1 - 0.019 14.9 0.0 0.036 14.0 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) GDA1_CD39 PF01150.12 KOO33522.1 - 5.5e-23 81.1 0.0 6.1e-23 81.0 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family IQ PF00612.22 KOO33524.1 - 0.00056 19.3 0.0 0.0021 17.5 0.0 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif RNA_pol_L_2 PF13656.1 KOO33525.1 - 1.2e-26 91.9 0.0 1.5e-26 91.6 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 KOO33525.1 - 1.6e-07 30.3 0.0 2.1e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain adh_short PF00106.20 KOO33526.1 - 7.5e-18 65.0 5.0 7.5e-18 65.0 3.4 2.6 3 0 0 3 3 3 1 short chain dehydrogenase KR PF08659.5 KOO33526.1 - 5.9e-06 26.0 2.2 1.4e-05 24.8 1.5 1.6 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 KOO33526.1 - 8.9e-05 22.3 0.0 0.00017 21.4 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 KOO33526.1 - 0.0073 15.7 0.0 0.014 14.8 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.3 KOO33526.1 - 0.076 12.8 1.0 0.45 10.3 0.7 2.4 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase PsbQ PF05757.6 KOO33526.1 - 2.1 7.7 7.5 3.8 6.8 4.8 1.8 2 1 0 2 2 2 0 Oxygen evolving enhancer protein 3 (PsbQ) SbmA_BacA PF05992.7 KOO33527.1 - 3.7e-44 151.2 0.0 4.2e-44 151.0 0.0 1.0 1 0 0 1 1 1 1 SbmA/BacA-like family ABC_membrane_2 PF06472.10 KOO33527.1 - 2.8e-08 33.2 0.0 1.1e-07 31.3 0.0 1.9 1 1 0 1 1 1 1 ABC transporter transmembrane region 2 eIF-5_eIF-2B PF01873.12 KOO33529.1 - 5.9e-28 97.0 0.0 5.1e-27 94.0 0.0 2.1 2 0 0 2 2 2 1 Domain found in IF2B/IF5 W2 PF02020.13 KOO33529.1 - 6.3e-19 67.7 2.1 6.3e-19 67.7 1.4 2.6 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Sec6 PF06046.8 KOO33530.1 - 1.5e-15 56.2 0.0 2.1e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec6 Mcp5_PH PF12814.2 KOO33530.1 - 0.00013 21.8 0.0 0.00023 21.0 0.0 1.3 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.24 KOO33530.1 - 0.044 13.9 0.0 0.11 12.7 0.0 1.6 1 1 0 1 1 1 0 PH domain PAP_fibrillin PF04755.7 KOO33531.1 - 2.9e-18 66.3 0.0 9.1e-18 64.6 0.0 1.8 1 1 0 1 1 1 1 PAP_fibrillin Abhydrolase_6 PF12697.2 KOO33531.1 - 1.4e-09 38.2 2.3 2.9e-09 37.1 1.6 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO33531.1 - 2.1e-05 24.2 0.0 3.8e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 KOO33531.1 - 5.2e-05 22.9 0.0 9.7e-05 22.0 0.0 1.4 1 1 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.9 KOO33531.1 - 0.0088 15.3 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) LCAT PF02450.10 KOO33531.1 - 0.011 14.6 0.0 0.025 13.5 0.0 1.4 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase ATP-synt_Eps PF04627.8 KOO33531.1 - 0.012 15.1 0.0 0.028 13.9 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial ATP synthase epsilon chain DUF900 PF05990.7 KOO33531.1 - 0.013 14.8 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_1 PF00561.15 KOO33531.1 - 0.072 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Mito_fiss_reg PF05308.6 KOO33531.1 - 0.079 12.3 3.0 0.13 11.6 2.0 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator Arm PF00514.18 KOO33533.1 - 1.6e-34 116.5 30.9 1.7e-06 27.6 0.1 7.1 7 0 0 7 7 7 7 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 KOO33533.1 - 0.01 14.9 0.0 39 3.2 0.0 4.1 1 1 3 5 5 5 0 Armadillo-like HEAT_2 PF13646.1 KOO33533.1 - 0.81 10.0 46.6 1.3 9.3 6.2 4.4 1 1 4 5 5 5 0 HEAT repeats ABC_membrane PF00664.18 KOO33534.1 - 5.3e-46 157.2 15.0 3.1e-23 82.5 4.1 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 KOO33534.1 - 3.4e-45 153.6 0.0 8.6e-25 87.6 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 KOO33534.1 - 1e-10 41.2 0.0 0.0032 16.7 0.0 4.2 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 KOO33534.1 - 4.9e-08 32.3 0.0 0.00063 19.2 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.1 KOO33534.1 - 1.1e-07 32.0 0.3 0.0048 16.9 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.1 KOO33534.1 - 6.5e-07 29.6 0.0 0.0056 16.6 0.0 3.8 4 0 0 4 4 4 1 AAA domain AAA_23 PF13476.1 KOO33534.1 - 8.7e-07 29.4 0.0 3.9e-05 24.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 KOO33534.1 - 1e-06 28.3 0.0 0.0032 16.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 KOO33534.1 - 4.2e-06 26.0 0.0 0.02 14.0 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 KOO33534.1 - 1.5e-05 24.9 0.1 0.17 11.8 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_17 PF13207.1 KOO33534.1 - 6.7e-05 23.7 0.0 0.32 11.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain T2SE PF00437.15 KOO33534.1 - 6.7e-05 21.9 0.1 0.0055 15.6 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_22 PF13401.1 KOO33534.1 - 0.0001 22.4 0.2 0.066 13.3 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_10 PF12846.2 KOO33534.1 - 0.00026 20.5 3.3 0.15 11.4 0.1 3.0 2 1 1 3 3 3 2 AAA-like domain DUF87 PF01935.12 KOO33534.1 - 0.00041 20.2 0.8 0.41 10.4 0.1 2.5 2 0 0 2 2 2 2 Domain of unknown function DUF87 Miro PF08477.8 KOO33534.1 - 0.00066 20.1 1.4 1.4 9.3 0.2 2.6 2 0 0 2 2 2 2 Miro-like protein Zeta_toxin PF06414.7 KOO33534.1 - 0.0013 17.8 0.4 0.74 8.8 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin Arch_ATPase PF01637.13 KOO33534.1 - 0.0035 17.0 0.0 0.0098 15.6 0.0 1.7 2 0 0 2 2 1 1 Archaeal ATPase Adeno_IVa2 PF02456.10 KOO33534.1 - 0.0041 15.8 0.1 0.07 11.7 0.0 2.4 3 0 0 3 3 3 1 Adenovirus IVa2 protein FtsK_SpoIIIE PF01580.13 KOO33534.1 - 0.0065 15.9 1.1 0.47 9.9 0.0 2.7 3 0 0 3 3 2 1 FtsK/SpoIIIE family MobB PF03205.9 KOO33534.1 - 0.01 15.5 0.7 5 6.8 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B RNA_helicase PF00910.17 KOO33534.1 - 0.011 15.9 0.0 2.2 8.4 0.0 2.8 3 0 0 3 3 2 0 RNA helicase AAA_18 PF13238.1 KOO33534.1 - 0.017 15.4 0.3 2.9 8.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.1 KOO33534.1 - 0.022 14.3 3.6 3.1 7.3 0.0 3.3 2 1 0 2 2 2 0 AAA domain Dynamin_N PF00350.18 KOO33534.1 - 0.025 14.4 1.8 1.4 8.7 0.0 2.5 2 0 0 2 2 2 0 Dynamin family AAA_33 PF13671.1 KOO33534.1 - 0.026 14.3 0.2 0.38 10.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain ABC_ATPase PF09818.4 KOO33534.1 - 0.028 13.0 0.3 5 5.6 0.0 3.0 3 0 0 3 3 3 0 Predicted ATPase of the ABC class IstB_IS21 PF01695.12 KOO33534.1 - 0.03 13.7 0.1 7.3 5.9 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein ArgK PF03308.11 KOO33534.1 - 0.037 12.7 0.6 0.92 8.2 0.0 2.6 3 0 0 3 3 3 0 ArgK protein AAA_19 PF13245.1 KOO33534.1 - 0.055 13.2 0.2 0.055 13.2 0.1 3.6 4 0 0 4 4 2 0 Part of AAA domain NB-ARC PF00931.17 KOO33534.1 - 0.06 12.1 0.0 21 3.8 0.0 3.0 3 0 0 3 3 3 0 NB-ARC domain cobW PF02492.14 KOO33534.1 - 0.093 12.1 1.9 0.21 11.0 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.24 KOO33534.1 - 0.11 12.7 0.0 2.9 8.0 0.0 3.1 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Guanylate_kin PF00625.16 KOO33534.1 - 0.18 11.2 0.1 1.1 8.6 0.0 2.0 2 0 0 2 2 2 0 Guanylate kinase AAA_24 PF13479.1 KOO33534.1 - 0.18 11.3 0.4 0.9 9.0 0.1 2.0 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.8 KOO33534.1 - 0.19 10.6 0.1 5.2 5.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) NACHT PF05729.7 KOO33534.1 - 0.2 11.3 0.6 1.6 8.3 0.0 2.4 2 0 0 2 2 2 0 NACHT domain Viral_helicase1 PF01443.13 KOO33534.1 - 0.21 11.0 0.0 4.1 6.8 0.0 2.8 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.4 KOO33534.1 - 0.27 10.1 0.6 5.2 5.9 0.0 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ATP_bind_1 PF03029.12 KOO33534.1 - 0.45 10.0 3.3 3.2 7.2 0.1 2.5 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein AAA_13 PF13166.1 KOO33534.1 - 0.56 8.5 0.0 0.99 7.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain Form_Nir_trans PF01226.12 KOO33535.1 - 1.8e-26 92.5 6.9 1.9e-26 92.4 4.8 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter DUF992 PF06186.6 KOO33535.1 - 0.078 12.3 0.1 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF992) Yip1 PF04893.12 KOO33535.1 - 0.84 9.1 14.4 1.7 8.1 9.9 1.5 1 1 0 1 1 1 0 Yip1 domain PsbX PF06596.6 KOO33535.1 - 7.2 6.3 7.0 1 9.0 1.7 2.0 2 0 0 2 2 2 0 Photosystem II reaction centre X protein (PsbX) TPR_11 PF13414.1 KOO33536.1 - 2.8e-51 171.0 44.1 1.1e-13 50.6 3.7 7.5 6 1 1 8 8 7 5 TPR repeat TPR_2 PF07719.12 KOO33536.1 - 1.2e-22 77.9 55.6 0.00012 21.7 0.3 12.5 12 1 1 13 13 13 7 Tetratricopeptide repeat TPR_1 PF00515.23 KOO33536.1 - 2.2e-22 77.6 42.8 0.00013 21.4 0.2 10.6 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_16 PF13432.1 KOO33536.1 - 3.6e-21 75.2 55.0 6.7e-06 26.6 0.1 8.5 4 3 4 8 8 8 6 Tetratricopeptide repeat DnaJ PF00226.26 KOO33536.1 - 1.2e-17 63.3 0.1 3.8e-17 61.7 0.1 1.9 1 0 0 1 1 1 1 DnaJ domain TPR_14 PF13428.1 KOO33536.1 - 3.3e-16 58.3 59.7 6.3e-06 26.3 1.4 10.8 8 3 4 12 12 12 5 Tetratricopeptide repeat Apc3 PF12895.2 KOO33536.1 - 2e-12 47.0 26.6 0.0016 18.5 1.4 5.7 5 1 1 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 KOO33536.1 - 2.1e-12 47.1 45.8 1.6e-05 25.1 6.3 8.0 4 3 4 8 8 8 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOO33536.1 - 1.4e-11 44.1 46.1 0.00078 19.3 1.9 8.2 4 3 3 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.1 KOO33536.1 - 1.8e-08 33.9 14.8 0.72 10.2 0.1 7.9 8 0 0 8 8 6 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO33536.1 - 5.3e-08 32.0 15.2 0.057 13.2 0.0 8.1 8 1 1 9 9 8 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO33536.1 - 6.8e-08 31.7 24.6 0.26 11.1 0.1 9.2 8 1 1 9 9 9 4 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO33536.1 - 0.00096 18.9 7.6 0.13 12.1 0.0 5.0 5 0 0 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat PPR PF01535.15 KOO33536.1 - 0.04 13.9 0.7 58 3.9 0.0 4.5 5 0 0 5 5 4 0 PPR repeat TPR_6 PF13174.1 KOO33536.1 - 0.23 11.9 0.1 0.18 12.3 0.2 8.7 10 0 0 10 10 8 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO33536.1 - 0.36 10.7 38.2 0.41 10.5 2.9 7.1 6 1 1 7 7 7 0 Tetratricopeptide repeat ChAPs PF09295.5 KOO33536.1 - 0.9 8.2 3.5 0.9 8.2 0.3 2.1 2 0 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) His_Phos_1 PF00300.17 KOO33537.1 - 6.6e-13 49.0 0.0 2.9e-12 46.9 0.0 2.0 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) Pkinase PF00069.20 KOO33537.1 - 2e-05 23.8 0.0 4.1e-05 22.8 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33537.1 - 7.7e-05 21.8 0.0 0.00035 19.7 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Spt4 PF06093.8 KOO33537.1 - 0.12 12.2 0.1 0.21 11.4 0.1 1.4 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger RRM_1 PF00076.17 KOO33538.1 - 8.2e-07 28.5 0.0 1.5e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO33538.1 - 0.012 15.5 0.0 0.029 14.3 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.27 KOO33539.1 - 4.9e-28 95.9 6.1 8.9e-11 41.2 0.3 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat RRM_6 PF14259.1 KOO33539.1 - 9.1e-05 22.3 0.0 0.00074 19.4 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) NACHT PF05729.7 KOO33539.1 - 0.00054 19.6 0.0 0.0013 18.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain RRM_1 PF00076.17 KOO33539.1 - 0.0032 17.0 0.0 0.016 14.8 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cytochrom_D1 PF02239.11 KOO33539.1 - 0.015 13.6 0.2 0.095 10.9 0.0 1.8 1 1 1 2 2 2 0 Cytochrome D1 heme domain AAA_25 PF13481.1 KOO33539.1 - 0.035 13.5 0.0 0.087 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF664 PF04978.7 KOO33540.1 - 0.056 13.6 0.2 0.94 9.7 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF664) PI-PLC-X PF00388.14 KOO33542.1 - 2.6e-22 78.7 0.1 6.4e-12 45.0 0.0 2.4 1 1 1 2 2 2 2 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.14 KOO33542.1 - 5.6e-21 74.7 0.0 1.2e-20 73.6 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.6 KOO33542.1 - 0.0007 19.5 0.0 0.0036 17.2 0.0 2.1 1 1 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.25 KOO33542.1 - 0.048 13.5 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 C2 domain Mcp5_PH PF12814.2 KOO33542.1 - 0.051 13.5 0.0 0.15 11.9 0.0 1.8 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology Cystatin PF00031.16 KOO33543.1 - 0.0051 16.9 0.0 0.0083 16.2 0.0 1.4 1 0 0 1 1 1 1 Cystatin domain EF-hand_1 PF00036.27 KOO33544.1 - 4.8e-22 75.5 0.8 1.5e-05 23.9 0.2 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO33544.1 - 1.9e-19 69.5 2.4 3.4e-08 33.5 0.1 3.9 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO33544.1 - 8.1e-19 65.7 0.4 0.0023 17.6 0.0 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO33544.1 - 1.1e-17 62.4 3.9 2.1e-05 23.6 0.6 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO33544.1 - 2.1e-12 46.4 0.9 0.0014 18.2 0.2 3.9 3 1 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO33544.1 - 7.6e-05 22.7 0.0 0.00084 19.3 0.0 2.2 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOO33544.1 - 0.00038 20.2 0.0 0.061 13.2 0.0 3.1 3 0 0 3 3 3 1 EF-hand domain Toprim_2 PF13155.1 KOO33544.1 - 0.019 15.2 0.1 1.4 9.2 0.0 2.8 1 1 2 3 3 3 0 Toprim-like EF-hand_4 PF12763.2 KOO33544.1 - 0.02 14.6 0.1 0.74 9.5 0.0 2.8 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO33544.1 - 0.068 12.8 0.1 7.4 6.3 0.0 3.1 4 0 0 4 4 4 0 EF hand FG-GAP PF01839.18 KOO33544.1 - 0.1 12.3 0.3 0.21 11.3 0.2 1.5 1 0 0 1 1 1 0 FG-GAP repeat HATPase_c PF02518.21 KOO33546.1 - 2.2e-05 24.1 0.0 4.6e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Desulfoferrodox PF01880.13 KOO33547.1 - 1.2e-08 35.1 0.1 2.3e-08 34.1 0.1 1.5 1 1 0 1 1 1 1 Desulfoferrodoxin Cwf_Cwc_15 PF04889.7 KOO33548.1 - 6.7 6.3 22.8 4.1 7.0 3.4 3.3 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein AAA_2 PF07724.9 KOO33549.1 - 9.4e-15 54.9 0.0 5.8e-14 52.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 KOO33549.1 - 1.1e-09 38.6 0.0 3.4e-09 37.0 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.16 KOO33549.1 - 3.8e-06 26.2 0.7 0.11 11.6 0.1 3.3 2 1 1 3 3 3 2 Magnesium chelatase, subunit ChlI MCM PF00493.18 KOO33549.1 - 1.9e-05 23.6 0.0 3.3e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 MCM2/3/5 family AAA_5 PF07728.9 KOO33549.1 - 9e-05 22.2 1.4 0.00044 20.0 0.1 2.8 3 1 0 3 3 2 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 KOO33549.1 - 0.00015 21.2 0.1 0.00042 19.7 0.1 1.7 1 1 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.1 KOO33549.1 - 0.00023 21.1 0.1 0.00023 21.1 0.1 3.1 1 1 1 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 KOO33549.1 - 0.00024 21.9 0.0 0.00075 20.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 KOO33549.1 - 0.0011 18.4 0.1 0.0023 17.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.1 KOO33549.1 - 0.0022 18.1 0.6 0.013 15.6 0.0 2.5 3 1 0 3 3 2 1 AAA domain AAA_33 PF13671.1 KOO33549.1 - 0.0062 16.4 0.6 0.022 14.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.21 KOO33549.1 - 0.011 15.1 0.0 0.21 11.0 0.0 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_28 PF13521.1 KOO33549.1 - 0.013 15.5 0.3 0.044 13.7 0.0 2.1 2 0 0 2 2 1 0 AAA domain ABC_tran PF00005.22 KOO33549.1 - 0.018 15.3 0.0 0.054 13.7 0.0 1.8 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.1 KOO33549.1 - 0.022 15.0 0.0 0.046 14.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.6 KOO33549.1 - 0.027 14.0 0.0 0.47 10.0 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 KOO33549.1 - 0.059 13.0 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain VWA_CoxE PF05762.9 KOO33549.1 - 0.071 12.2 6.2 0.2 10.7 4.3 1.7 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein AAA_21 PF13304.1 KOO33549.1 - 0.071 13.0 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 KOO33549.1 - 0.078 12.4 3.5 0.2 11.0 0.1 2.5 2 1 0 2 2 2 0 AAA-like domain Bac_DnaA PF00308.13 KOO33549.1 - 0.1 12.2 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_25 PF13481.1 KOO33549.1 - 0.11 11.8 1.3 0.27 10.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 KOO33549.1 - 0.12 11.9 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 KOO33549.1 - 0.17 11.0 0.0 0.3 10.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 PduV-EutP PF10662.4 KOO33549.1 - 0.2 11.1 0.0 0.33 10.4 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.17 KOO33549.1 - 0.21 11.8 0.0 0.37 10.9 0.0 1.4 1 0 0 1 1 1 0 RNA helicase Glutaredoxin PF00462.19 KOO33550.1 - 1.4e-05 24.9 0.0 2.4e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin zf-C3HC4_2 PF13923.1 KOO33551.1 - 5.5e-09 35.8 5.9 8.1e-09 35.3 4.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO33551.1 - 9.6e-08 31.5 5.9 1.3e-07 31.1 4.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO33551.1 - 1.7e-06 27.6 5.2 2.6e-06 27.0 3.6 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 KOO33551.1 - 4.1e-06 26.3 4.3 5.3e-06 26.0 3.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 KOO33551.1 - 8.5e-06 25.3 3.6 1.2e-05 24.9 2.5 1.3 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.1 KOO33551.1 - 1.3e-05 24.8 5.1 1.8e-05 24.4 3.5 1.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.1 KOO33551.1 - 2.1e-05 24.2 6.1 4.1e-05 23.3 4.3 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Cript PF10235.4 KOO33551.1 - 0.56 10.5 3.6 0.83 10.0 2.5 1.3 1 1 0 1 1 1 0 Microtubule-associated protein CRIPT Bud13 PF09736.4 KOO33552.1 - 1.8e-05 25.0 1.6 0.0013 18.9 0.0 2.3 2 1 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex BAF1_ABF1 PF04684.8 KOO33552.1 - 0.037 12.8 5.6 0.046 12.5 3.9 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Zip PF02535.17 KOO33552.1 - 1.5 7.7 4.0 2 7.3 2.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Kelch_6 PF13964.1 KOO33553.1 - 2.8e-10 39.9 0.3 0.0038 17.3 0.0 5.1 4 1 1 5 5 5 2 Kelch motif Kelch_3 PF13415.1 KOO33553.1 - 2e-08 34.1 10.7 0.00083 19.4 0.0 5.6 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.20 KOO33553.1 - 7e-08 31.8 0.0 0.042 13.4 0.0 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.1 KOO33553.1 - 1.6e-07 30.9 1.4 0.55 10.0 0.0 4.4 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.10 KOO33553.1 - 1.3e-05 24.7 1.3 5.7 6.8 0.0 4.7 4 1 0 4 4 4 1 Kelch motif Kelch_5 PF13854.1 KOO33553.1 - 0.00021 21.1 0.8 0.0041 17.0 0.0 3.1 3 0 0 3 3 3 1 Kelch motif SKG6 PF08693.5 KOO33553.1 - 0.12 11.7 0.2 0.27 10.6 0.2 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain C2 PF00168.25 KOO33555.1 - 7.5e-18 64.1 0.0 2.4e-17 62.5 0.0 1.8 2 0 0 2 2 2 1 C2 domain EF-hand_6 PF13405.1 KOO33555.1 - 5.2e-17 60.1 2.4 8.9e-06 25.1 0.0 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.1 KOO33555.1 - 1.2e-14 52.9 0.2 6.5e-05 22.0 0.0 3.6 3 0 0 3 3 3 2 EF hand EF-hand_1 PF00036.27 KOO33555.1 - 1.8e-13 48.7 0.0 4.8e-05 22.3 0.0 3.6 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.1 KOO33555.1 - 3.9e-12 46.1 0.0 1.9e-06 27.9 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO33555.1 - 1.9e-05 24.1 0.1 0.36 10.4 0.0 3.4 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.1 KOO33555.1 - 0.018 14.9 0.0 2.3 8.2 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain CAP_N PF01213.14 KOO33555.1 - 0.14 11.3 3.5 0.27 10.4 2.5 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.6 KOO33555.1 - 0.3 10.4 1.3 0.44 9.8 0.9 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator TPR_10 PF13374.1 KOO33556.1 - 3e-46 154.0 21.5 1.4e-13 50.2 0.5 4.0 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_12 PF13424.1 KOO33556.1 - 1.4e-38 130.6 9.9 5.6e-20 71.0 1.5 2.3 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO33556.1 - 2.1e-19 68.2 7.9 0.00013 21.4 0.0 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.12 KOO33556.1 - 4.5e-14 51.1 11.9 0.0033 17.2 0.1 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.1 KOO33556.1 - 3.1e-12 45.9 7.6 9.5e-06 25.1 0.4 3.3 1 1 2 3 3 3 3 TPR repeat TPR_8 PF13181.1 KOO33556.1 - 1.6e-11 43.1 3.5 0.013 15.2 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_4 PF07721.9 KOO33556.1 - 8e-11 41.2 1.7 0.12 12.8 0.0 5.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO33556.1 - 1.8e-09 37.0 10.5 0.073 13.2 0.0 5.3 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO33556.1 - 4.7e-09 36.6 13.9 0.0001 22.8 1.6 3.8 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO33556.1 - 6.7e-08 31.7 14.3 0.042 13.6 0.1 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat Osmo_CC PF08946.5 KOO33556.1 - 6.6e-05 22.8 0.5 2.2 8.3 0.0 3.4 3 0 0 3 3 3 2 Osmosensory transporter coiled coil TPR_19 PF14559.1 KOO33556.1 - 0.00057 20.1 10.3 0.027 14.8 1.8 3.1 1 1 1 3 3 3 2 Tetratricopeptide repeat TPR_3 PF07720.7 KOO33556.1 - 0.00061 19.5 0.1 4.4 7.2 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF2399 PF09664.5 KOO33556.1 - 0.0016 18.3 2.0 0.96 9.2 0.0 3.0 1 1 2 3 3 3 1 Protein of unknown function C-terminus (DUF2399) TPR_14 PF13428.1 KOO33556.1 - 0.0022 18.4 18.8 1.3 9.8 0.3 4.2 2 2 2 4 4 4 2 Tetratricopeptide repeat ApoLp-III PF07464.6 KOO33556.1 - 0.0053 16.7 0.0 3.8 7.5 0.0 2.9 1 1 2 3 3 3 1 Apolipophorin-III precursor (apoLp-III) TPR_6 PF13174.1 KOO33556.1 - 0.0082 16.5 9.3 11 6.7 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_5 PF12688.2 KOO33556.1 - 0.021 14.8 8.9 0.13 12.3 2.3 3.1 1 1 2 3 3 3 0 Tetratrico peptide repeat MIT PF04212.13 KOO33556.1 - 0.044 13.6 1.9 18 5.3 0.2 3.4 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain HisKA_3 PF07730.8 KOO33556.1 - 0.42 10.9 9.7 2.6 8.4 0.2 3.6 3 1 1 4 4 4 0 Histidine kinase TFIIA_gamma_N PF02268.11 KOO33556.1 - 1 8.9 6.4 2.3 7.8 0.3 3.2 3 0 0 3 3 3 0 Transcription initiation factor IIA, gamma subunit, helical domain TPR_12 PF13424.1 KOO33557.1 - 1.6e-65 217.0 22.3 1.8e-17 63.0 0.1 6.0 3 1 4 7 7 7 5 Tetratricopeptide repeat TPR_10 PF13374.1 KOO33557.1 - 1.4e-54 180.5 30.0 1.4e-12 47.1 0.2 7.7 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_1 PF00515.23 KOO33557.1 - 3.6e-14 51.6 3.8 0.003 17.1 0.0 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_4 PF07721.9 KOO33557.1 - 1.6e-12 46.5 20.6 0.013 15.8 0.2 8.0 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.12 KOO33557.1 - 5.6e-11 41.4 9.8 0.13 12.2 0.0 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.1 KOO33557.1 - 8.7e-11 41.1 5.6 0.22 11.7 0.0 6.7 8 0 0 8 8 6 4 Tetratricopeptide repeat TPR_11 PF13414.1 KOO33557.1 - 6.4e-10 38.5 1.0 0.00095 18.7 0.1 3.9 2 1 2 4 4 4 3 TPR repeat TPR_8 PF13181.1 KOO33557.1 - 7.7e-09 34.7 0.9 0.86 9.5 0.0 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO33557.1 - 4.7e-08 33.4 18.8 0.0024 18.5 1.2 6.2 3 1 3 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.1 KOO33557.1 - 4e-07 30.2 9.7 0.0041 17.4 0.4 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO33557.1 - 1.6e-06 27.4 11.9 0.18 11.7 0.1 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat Osmo_CC PF08946.5 KOO33557.1 - 4.5e-06 26.5 7.2 4.6 7.3 0.0 6.1 7 1 0 7 7 6 1 Osmosensory transporter coiled coil ApoLp-III PF07464.6 KOO33557.1 - 0.029 14.4 0.1 85 3.1 0.0 4.2 2 1 3 5 5 5 0 Apolipophorin-III precursor (apoLp-III) TPR_14 PF13428.1 KOO33557.1 - 0.1 13.3 23.4 19 6.2 0.1 7.3 3 2 3 6 6 6 0 Tetratricopeptide repeat Sugar_tr PF00083.19 KOO33558.1 - 6.8e-21 74.3 19.0 9.8e-18 63.9 4.6 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 KOO33558.1 - 2.4e-10 39.6 56.1 4.7e-10 38.7 33.5 2.6 1 1 0 1 1 1 1 Major Facilitator Superfamily GPI2 PF06432.6 KOO33558.1 - 0.63 9.3 3.4 0.64 9.3 0.1 2.4 1 1 1 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase TIP49 PF06068.8 KOO33560.1 - 3e-190 632.1 1.0 3.5e-190 631.8 0.7 1.0 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.24 KOO33560.1 - 1e-11 45.1 0.6 4e-07 30.2 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 KOO33560.1 - 9.4e-11 41.2 4.0 6.7e-07 28.5 0.1 2.9 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KOO33560.1 - 3.3e-07 30.4 0.3 0.014 15.5 0.1 2.7 1 1 1 2 2 2 2 AAA domain AAA_16 PF13191.1 KOO33560.1 - 4.9e-07 29.9 0.0 0.003 17.5 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_28 PF13521.1 KOO33560.1 - 6.1e-05 23.0 0.0 0.00017 21.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOO33560.1 - 6.6e-05 22.5 0.1 0.00069 19.3 0.0 2.5 2 1 0 2 2 2 1 Part of AAA domain Mg_chelatase PF01078.16 KOO33560.1 - 6.9e-05 22.1 0.8 0.0027 16.8 0.2 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 KOO33560.1 - 0.00016 21.1 0.1 0.001 18.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 KOO33560.1 - 0.00017 21.3 0.1 0.025 14.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 KOO33560.1 - 0.001 18.9 0.0 1.1 9.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 KOO33560.1 - 0.0016 18.7 0.1 0.017 15.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 KOO33560.1 - 0.0049 16.2 0.4 0.017 14.5 0.1 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_17 PF13207.1 KOO33560.1 - 0.005 17.6 0.0 0.016 15.9 0.0 1.9 2 1 0 2 2 1 1 AAA domain AAA_33 PF13671.1 KOO33560.1 - 0.0077 16.1 0.0 0.028 14.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.21 KOO33560.1 - 0.0079 15.6 0.7 2.9 7.3 0.1 2.7 2 1 0 2 2 2 1 Sigma-54 interaction domain Zeta_toxin PF06414.7 KOO33560.1 - 0.02 14.0 0.4 0.041 12.9 0.3 1.5 1 0 0 1 1 1 0 Zeta toxin DnaB_C PF03796.10 KOO33560.1 - 0.02 13.8 0.0 0.036 12.9 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain DUF2075 PF09848.4 KOO33560.1 - 0.023 13.7 0.0 0.054 12.4 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) MinE PF03776.9 KOO33560.1 - 0.066 12.7 0.1 0.17 11.4 0.1 1.6 1 0 0 1 1 1 0 Septum formation topological specificity factor MinE GvpD PF07088.6 KOO33560.1 - 0.074 11.3 0.2 0.52 8.5 0.0 2.0 2 0 0 2 2 2 0 GvpD gas vesicle protein UPF0079 PF02367.12 KOO33560.1 - 0.08 12.5 0.2 0.27 10.8 0.1 1.9 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 ResIII PF04851.10 KOO33560.1 - 0.085 12.6 0.3 2 8.2 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DUF815 PF05673.8 KOO33560.1 - 0.11 11.4 0.0 0.24 10.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NACHT PF05729.7 KOO33560.1 - 0.13 11.8 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain PhoH PF02562.11 KOO33560.1 - 0.17 11.1 2.4 0.17 11.1 0.3 2.0 2 0 0 2 2 2 0 PhoH-like protein Med3 PF11593.3 KOO33561.1 - 0.61 9.2 1.7 0.77 8.9 1.2 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal SGL PF08450.7 KOO33562.1 - 2.6e-06 26.9 0.0 3.1e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolaconase/LRE-like region CENP-F_leu_zip PF10473.4 KOO33563.1 - 0.01 15.6 6.2 0.01 15.6 4.3 2.6 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF802 PF05650.6 KOO33563.1 - 0.023 14.8 2.9 0.023 14.8 2.0 3.3 2 1 0 2 2 2 0 Domain of unknown function (DUF802) AAA_13 PF13166.1 KOO33563.1 - 0.31 9.4 16.3 0.38 9.1 11.3 1.0 1 0 0 1 1 1 0 AAA domain HD_3 PF13023.1 KOO33563.1 - 4 7.1 10.2 0.51 10.0 3.6 1.9 1 1 1 2 2 2 0 HD domain Arm PF00514.18 KOO33564.1 - 0.0023 17.6 11.6 1.1 9.1 0.1 5.2 5 0 0 5 5 5 3 Armadillo/beta-catenin-like repeat HEAT PF02985.17 KOO33564.1 - 0.31 11.2 12.1 3.3 8.0 0.3 4.9 5 0 0 5 5 5 0 HEAT repeat Ank_2 PF12796.2 KOO33566.1 - 7.1e-24 83.9 0.3 1.3e-13 51.1 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO33566.1 - 2.7e-21 75.4 1.4 2.3e-09 37.5 0.2 2.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO33566.1 - 2.4e-15 55.4 0.0 3.6e-07 29.6 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 KOO33566.1 - 3.4e-14 52.5 1.2 3.3e-12 46.2 0.1 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO33566.1 - 1.3e-09 37.3 0.0 7.5e-06 25.6 0.0 3.2 3 0 0 3 3 3 1 Ankyrin repeat Abhydrolase_9_N PF15420.1 KOO33567.1 - 0.009 15.7 0.1 0.016 14.9 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta-hydrolase family N-terminus ABC_tran PF00005.22 KOO33568.1 - 1.4e-31 109.6 0.0 2.1e-31 109.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.18 KOO33568.1 - 3.4e-22 79.1 0.0 5.8e-22 78.3 0.0 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_16 PF13191.1 KOO33568.1 - 5.5e-06 26.4 1.7 1.8e-05 24.8 1.2 1.8 1 1 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.14 KOO33568.1 - 5.7e-06 25.7 0.0 0.00031 20.0 0.0 2.1 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 KOO33568.1 - 6.2e-05 23.1 0.0 0.018 15.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 KOO33568.1 - 0.00041 19.5 0.0 0.00071 18.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA PF00004.24 KOO33568.1 - 0.0011 19.1 0.1 2 8.6 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.1 KOO33568.1 - 0.0011 18.4 0.0 0.0024 17.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SbcCD_C PF13558.1 KOO33568.1 - 0.0021 17.9 0.3 0.014 15.2 0.2 2.3 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.1 KOO33568.1 - 0.0047 16.3 0.7 0.096 12.0 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 KOO33568.1 - 0.0064 17.3 0.0 0.015 16.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain ABC_ATPase PF09818.4 KOO33568.1 - 0.011 14.3 0.0 0.078 11.5 0.1 1.9 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_21 PF13304.1 KOO33568.1 - 0.013 15.5 0.0 2.1 8.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.9 KOO33568.1 - 0.023 14.4 0.1 0.45 10.2 0.0 2.4 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 KOO33568.1 - 0.029 13.4 0.0 0.059 12.4 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin NTPase_1 PF03266.10 KOO33568.1 - 0.039 13.6 0.0 5.3 6.7 0.0 2.2 2 0 0 2 2 2 0 NTPase AAA_19 PF13245.1 KOO33568.1 - 0.053 13.2 1.3 0.41 10.4 0.0 2.7 2 0 0 2 2 2 0 Part of AAA domain AAA_10 PF12846.2 KOO33568.1 - 0.068 12.5 0.0 0.47 9.8 0.0 2.0 2 0 0 2 2 2 0 AAA-like domain NACHT PF05729.7 KOO33568.1 - 0.08 12.6 0.1 0.35 10.5 0.0 1.9 2 0 0 2 2 2 0 NACHT domain Rad17 PF03215.10 KOO33568.1 - 0.12 11.0 0.0 0.2 10.2 0.0 1.3 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_28 PF13521.1 KOO33568.1 - 0.15 12.0 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Gp_dh_C PF02800.15 KOO33569.1 - 6.6e-12 45.1 0.0 8.3e-12 44.8 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain IQ PF00612.22 KOO33570.1 - 0.015 14.8 2.6 0.04 13.5 1.8 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif CorA PF01544.13 KOO33570.1 - 0.56 9.1 3.2 0.65 8.9 0.3 2.3 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Hep_59 PF07052.6 KOO33571.1 - 6.7e-22 77.8 0.0 9.8e-22 77.2 0.0 1.3 1 0 0 1 1 1 1 Hepatocellular carcinoma-associated antigen 59 COX6B PF02297.12 KOO33572.1 - 4.1e-10 39.5 7.0 5.4e-10 39.1 4.9 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Pkinase PF00069.20 KOO33573.1 - 1.6e-45 155.3 0.0 4.6e-30 104.6 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain B56 PF01603.15 KOO33573.1 - 7.3e-29 100.5 0.0 1e-28 100.0 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Pkinase_Tyr PF07714.12 KOO33573.1 - 4.8e-24 84.8 0.0 3.8e-16 58.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.9 KOO33573.1 - 0.0013 17.8 0.0 0.0024 16.9 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 KOO33573.1 - 0.0079 15.1 0.0 2 7.2 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Sigma70_r2 PF04542.9 KOO33574.1 - 2.8e-23 81.2 0.1 1.8e-22 78.7 0.0 2.3 2 0 0 2 2 2 1 Sigma-70 region 2 Sigma70_r3 PF04539.11 KOO33574.1 - 2.2e-13 49.8 1.4 4e-09 36.2 0.0 2.5 2 0 0 2 2 2 2 Sigma-70 region 3 Sigma70_r4 PF04545.11 KOO33574.1 - 1.5e-11 43.3 1.0 4.3e-09 35.5 0.3 2.7 2 0 0 2 2 2 2 Sigma-70, region 4 Sigma70_r1_2 PF00140.15 KOO33574.1 - 0.0067 16.0 0.4 0.0067 16.0 0.3 2.4 2 1 0 2 2 2 1 Sigma-70 factor, region 1.2 HTH_3 PF01381.17 KOO33574.1 - 0.032 14.0 0.1 4.2 7.2 0.0 2.7 2 0 0 2 2 2 0 Helix-turn-helix UreE_N PF02814.10 KOO33574.1 - 0.12 11.8 3.1 0.26 10.8 0.1 2.7 3 0 0 3 3 3 0 UreE urease accessory protein, N-terminal domain HTH_23 PF13384.1 KOO33574.1 - 0.18 11.5 4.3 0.43 10.3 0.1 3.0 3 0 0 3 3 3 0 Homeodomain-like domain MIP-T3 PF10243.4 KOO33574.1 - 0.51 8.7 2.8 0.65 8.4 1.9 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 WW PF00397.21 KOO33575.1 - 8.8e-16 57.4 4.3 6e-11 42.0 0.6 2.5 2 0 0 2 2 2 2 WW domain zf-CCCH PF00642.19 KOO33575.1 - 0.0016 18.0 7.6 0.19 11.4 1.6 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) MbtH PF03621.8 KOO33575.1 - 0.36 10.2 2.3 16 4.9 0.1 2.4 2 0 0 2 2 2 0 MbtH-like protein Acetyltransf_1 PF00583.19 KOO33576.1 - 1.6e-06 28.0 0.0 3e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 KOO33576.1 - 0.0002 21.4 0.0 0.0004 20.4 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 KOO33576.1 - 0.00023 21.2 0.0 0.00056 20.0 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain TetR_N PF00440.18 KOO33576.1 - 0.038 13.6 2.4 0.15 11.7 0.0 2.6 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family Arm PF00514.18 KOO33577.1 - 5.1e-08 32.4 16.2 0.021 14.6 0.2 6.3 6 0 0 6 6 6 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 KOO33577.1 - 7.2e-08 32.7 21.4 0.0094 16.4 0.1 6.0 4 1 2 6 6 6 4 HEAT-like repeat HEAT_2 PF13646.1 KOO33577.1 - 1.4e-07 31.6 21.1 0.0001 22.5 5.3 3.5 1 1 2 3 3 3 3 HEAT repeats HEAT PF02985.17 KOO33577.1 - 8e-07 28.6 11.0 0.0035 17.2 0.1 5.1 6 0 0 6 6 6 2 HEAT repeat Adaptin_N PF01602.15 KOO33577.1 - 9e-06 24.2 0.1 0.016 13.5 0.0 2.2 1 1 1 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.2 KOO33577.1 - 0.032 14.0 0.0 0.23 11.2 0.0 2.3 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 ACT PF01842.20 KOO33577.1 - 0.049 13.1 0.1 0.2 11.2 0.1 2.1 1 0 0 1 1 1 0 ACT domain V-ATPase_H_C PF11698.3 KOO33577.1 - 0.092 12.6 0.5 4.7 7.1 0.1 3.0 3 0 0 3 3 3 0 V-ATPase subunit H Ceramidase_alk PF04734.8 KOO33579.1 - 1.1e-213 710.8 0.0 1.4e-213 710.6 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase Peptidase_M22 PF00814.20 KOO33580.1 - 3.7e-43 147.9 0.0 5.1e-43 147.4 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family UPF0079 PF02367.12 KOO33580.1 - 3.2e-18 65.5 0.0 8.8e-12 44.7 0.0 2.3 2 0 0 2 2 2 2 Uncharacterised P-loop hydrolase UPF0079 AAA_16 PF13191.1 KOO33580.1 - 0.0031 17.5 0.1 0.052 13.5 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain CmcH_NodU PF02543.10 KOO33580.1 - 0.0044 16.1 0.0 0.0064 15.6 0.0 1.2 1 0 0 1 1 1 1 Carbamoyltransferase NIF PF03031.13 KOO33581.1 - 5.1e-18 65.2 0.0 7.8e-18 64.6 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase PTCB-BRCT PF12738.2 KOO33581.1 - 0.006 16.4 0.3 0.012 15.4 0.2 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.21 KOO33581.1 - 0.091 12.9 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain DUF3353 PF11833.3 KOO33582.1 - 1.9e-09 37.2 0.7 1e-08 34.8 0.5 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3353) DnaJ PF00226.26 KOO33582.1 - 0.0015 18.1 0.2 0.0027 17.3 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain CytB6-F_Fe-S PF08802.5 KOO33582.1 - 0.016 15.1 0.8 0.062 13.3 0.6 2.0 1 0 0 1 1 1 0 Cytochrome B6-F complex Fe-S subunit Swi3 PF07962.7 KOO33583.1 - 2e-18 65.7 0.1 3.1e-18 65.1 0.1 1.3 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 DUF1178 PF06676.6 KOO33583.1 - 1.6 8.8 6.4 2.8 8.1 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1178) Baculo_PEP_C PF04513.7 KOO33584.1 - 0.014 15.2 0.1 1.8 8.4 0.1 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FliD_N PF02465.13 KOO33584.1 - 0.016 15.5 4.9 0.52 10.6 0.0 3.7 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 N-terminus UCH_1 PF13423.1 KOO33584.1 - 0.14 11.5 0.2 0.17 11.3 0.2 1.2 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Transglut_i_TM PF14400.1 KOO33584.1 - 0.24 10.9 1.5 0.58 9.6 1.1 1.7 1 0 0 1 1 1 0 Inactive transglutaminase fused to 7 transmembrane helices Snapin_Pallidin PF14712.1 KOO33584.1 - 0.77 10.1 5.5 9.2 6.6 1.0 2.5 1 1 1 2 2 2 0 Snapin/Pallidin APG6 PF04111.7 KOO33584.1 - 4.3 6.3 8.8 1.4 7.9 3.3 1.7 1 1 1 2 2 2 0 Autophagy protein Apg6 3-alpha PF03475.9 KOO33585.1 - 0.25 11.0 2.5 12 5.7 0.1 2.9 3 0 0 3 3 3 0 3-alpha domain NOA36 PF06524.7 KOO33585.1 - 5.8 6.0 6.5 7.3 5.7 4.5 1.1 1 0 0 1 1 1 0 NOA36 protein MORN PF02493.15 KOO33586.1 - 5.6e-32 107.5 43.0 4e-06 26.2 0.7 8.1 7 1 1 8 8 8 7 MORN repeat PUB PF09409.5 KOO33586.1 - 2.1e-19 69.0 0.0 4e-19 68.1 0.0 1.5 1 0 0 1 1 1 1 PUB domain Tom5 PF10642.4 KOO33587.1 - 2.1 8.0 9.9 0.15 11.7 1.5 2.9 2 0 0 2 2 2 0 Mitochondrial import receptor subunit or translocase FA_desaturase PF00487.19 KOO33588.1 - 1.5e-30 106.4 13.4 1.9e-30 106.1 9.3 1.1 1 0 0 1 1 1 1 Fatty acid desaturase Ribosomal_L39 PF00832.15 KOO33589.1 - 0.13 11.7 0.8 0.24 10.8 0.6 1.4 1 0 0 1 1 1 0 Ribosomal L39 protein EF-hand_1 PF00036.27 KOO33590.1 - 4.5e-26 88.1 5.7 7.2e-06 24.9 0.2 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO33590.1 - 7.8e-25 84.4 9.3 4e-05 23.1 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO33590.1 - 2.5e-23 81.9 3.2 1.1e-09 38.2 0.1 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO33590.1 - 2.1e-18 64.7 7.9 0.00043 19.5 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO33590.1 - 8.4e-14 50.9 8.1 0.0089 15.6 0.2 4.3 2 2 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO33590.1 - 8e-07 29.0 0.3 0.0099 15.8 0.0 3.3 2 2 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO33590.1 - 0.00047 19.8 0.2 0.86 9.3 0.0 3.8 4 0 0 4 4 4 1 Cytoskeletal-regulatory complex EF hand Pkinase PF00069.20 KOO33591.1 - 9.2e-45 152.8 0.0 1.3e-44 152.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33591.1 - 8.7e-40 136.4 0.0 1.4e-39 135.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO33591.1 - 0.091 11.7 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Shisa PF13908.1 KOO33591.1 - 0.83 9.8 0.0 0.83 9.8 0.0 2.7 3 0 0 3 3 3 0 Wnt and FGF inhibitory regulator Pyr_redox_dim PF02852.17 KOO33592.1 - 1.1e-13 51.0 0.4 1.8e-13 50.4 0.3 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.9 KOO33592.1 - 1.2e-07 31.8 0.1 2.7e-06 27.4 0.0 2.2 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOO33593.1 - 4.3e-07 30.2 0.3 1.2e-06 28.8 0.2 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOO33593.1 - 0.0009 19.3 0.1 0.0029 17.7 0.0 1.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 KOO33593.1 - 0.0009 19.1 0.4 0.0061 16.4 0.3 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DUF3793 PF12672.2 KOO33596.1 - 0.036 13.6 0.0 0.06 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3793) EF-hand_7 PF13499.1 KOO33597.1 - 2.2e-08 34.1 0.5 6.1e-08 32.6 0.1 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO33597.1 - 3.6e-08 32.1 0.8 0.0094 15.1 0.0 2.7 2 0 0 2 2 2 2 EF hand ADPrib_exo_Tox PF03496.9 KOO33597.1 - 2.9e-06 26.6 0.0 6.7e-06 25.4 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme LRR_6 PF13516.1 KOO33597.1 - 3e-06 26.7 2.0 22 5.4 0.0 7.6 8 0 0 8 8 8 0 Leucine Rich repeat ART PF01129.13 KOO33597.1 - 5.2e-06 25.7 0.0 9.2e-06 24.9 0.0 1.3 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase EF-hand_8 PF13833.1 KOO33597.1 - 8.8e-06 25.2 1.3 0.0043 16.6 0.0 2.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO33597.1 - 2e-05 23.7 0.3 0.038 13.3 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO33597.1 - 5.4e-05 22.7 0.1 0.017 14.9 0.1 2.9 2 0 0 2 2 2 1 EF-hand domain LRR_1 PF00560.28 KOO33597.1 - 0.015 15.2 1.8 8.8 6.7 0.0 5.1 6 0 0 6 6 5 0 Leucine Rich Repeat LRR_4 PF12799.2 KOO33597.1 - 0.039 13.5 4.8 9.1 6.0 0.2 4.5 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO33597.1 - 0.65 9.7 7.2 34 4.3 0.8 4.7 5 0 0 5 5 5 0 Leucine rich repeat Arm PF00514.18 KOO33598.1 - 4.9e-54 178.4 68.4 1.9e-05 24.2 0.3 13.1 13 0 0 13 13 13 12 Armadillo/beta-catenin-like repeat zf-H2C2_2 PF13465.1 KOO33598.1 - 1.8e-16 59.5 35.9 1.2e-06 28.5 0.9 5.0 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.21 KOO33598.1 - 3.8e-14 52.0 34.2 0.00012 22.2 1.5 4.2 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOO33598.1 - 2.1e-12 46.4 27.4 0.011 15.9 1.6 4.2 4 0 0 4 4 4 4 C2H2-type zinc finger DUF302 PF03625.9 KOO33598.1 - 2e-07 30.4 14.1 0.82 9.2 0.0 10.2 11 0 0 11 11 11 1 Domain of unknown function DUF302 PA14_2 PF10528.4 KOO33598.1 - 1e-06 28.6 0.3 44 4.0 0.0 8.8 2 1 8 11 11 11 0 GLEYA domain TRL PF13146.1 KOO33598.1 - 0.089 12.7 24.0 3.9 7.5 0.1 7.2 7 1 1 8 8 8 0 TRL-like protein family zf-C2H2_6 PF13912.1 KOO33598.1 - 0.17 11.8 22.6 0.11 12.4 0.5 4.4 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KOO33598.1 - 1.4 9.1 22.3 0.63 10.2 0.3 4.1 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding PolyA_pol_RNAbd PF12627.2 KOO33599.1 - 0.12 11.9 2.5 3.5 7.2 0.1 2.9 3 0 0 3 3 3 0 Probable RNA and SrmB- binding site of polymerase A Chloroa_b-bind PF00504.16 KOO33600.1 - 4.7e-30 104.8 0.0 6.1e-30 104.5 0.0 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein XPG_I PF00867.13 KOO33601.1 - 2.9e-22 78.5 0.0 5.7e-22 77.5 0.0 1.5 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 KOO33601.1 - 1.1e-14 54.5 0.0 1.8e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.2 KOO33601.1 - 5.5e-06 26.0 0.1 9.5e-06 25.2 0.1 1.3 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.15 KOO33601.1 - 0.0035 17.5 0.0 0.0075 16.4 0.0 1.4 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold Pox_G5 PF04599.7 KOO33601.1 - 0.14 10.7 0.0 0.23 10.0 0.0 1.3 1 0 0 1 1 1 0 Poxvirus G5 protein EF-hand_6 PF13405.1 KOO33602.1 - 2e-10 39.6 0.3 0.00036 20.1 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain Sigma70_r2 PF04542.9 KOO33602.1 - 4e-10 39.1 0.0 9.6e-10 37.9 0.0 1.7 1 0 0 1 1 1 1 Sigma-70 region 2 EF-hand_1 PF00036.27 KOO33602.1 - 2.4e-09 35.8 0.2 0.0022 17.1 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO33602.1 - 6.6e-09 35.7 1.8 8.2e-07 29.0 0.2 2.5 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO33602.1 - 3.1e-08 33.1 1.0 9.7e-07 28.3 0.1 2.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO33602.1 - 1.9e-07 30.1 0.2 0.0025 17.0 0.0 2.9 2 0 0 2 2 2 2 EF hand Sigma70_r4 PF04545.11 KOO33602.1 - 2.3e-05 23.6 0.2 2.3e-05 23.6 0.1 2.3 2 0 0 2 2 2 1 Sigma-70, region 4 Sigma70_r1_2 PF00140.15 KOO33602.1 - 0.0043 16.7 2.5 0.012 15.2 1.7 1.8 1 0 0 1 1 1 1 Sigma-70 factor, region 1.2 FAD-oxidase_C PF02913.14 KOO33603.1 - 1.3e-48 165.5 0.0 2.1e-48 164.8 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 KOO33603.1 - 3.5e-27 94.5 0.3 7.3e-27 93.5 0.2 1.6 1 0 0 1 1 1 1 FAD binding domain Fer4_8 PF13183.1 KOO33603.1 - 3.4e-08 33.3 3.5 9.8e-08 31.9 2.4 1.9 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.2 KOO33603.1 - 2.8e-07 30.8 3.0 7.1e-07 29.5 2.1 1.8 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_17 PF13534.1 KOO33603.1 - 1.8e-05 24.9 4.9 5.2e-05 23.5 3.4 1.9 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.1 KOO33603.1 - 0.00014 22.0 2.9 0.00038 20.6 2.0 1.8 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 KOO33603.1 - 0.00015 21.5 8.7 0.0019 17.9 6.6 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4 PF00037.22 KOO33603.1 - 0.00031 20.1 8.9 0.0021 17.5 1.0 2.6 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.1 KOO33603.1 - 0.00077 20.1 5.4 0.0018 19.0 3.8 1.7 1 0 0 1 1 1 1 4Fe-4S double cluster binding domain Fer4_21 PF14697.1 KOO33603.1 - 0.0017 18.2 2.4 0.32 10.8 0.3 2.7 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_18 PF13746.1 KOO33603.1 - 0.0053 17.1 1.4 2.4 8.6 0.0 3.1 3 0 0 3 3 3 1 4Fe-4S dicluster domain Fer4_20 PF14691.1 KOO33603.1 - 0.01 15.4 1.1 0.17 11.4 0.0 2.5 2 0 0 2 2 2 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster RRM_1 PF00076.17 KOO33603.1 - 0.21 11.2 0.1 0.56 9.8 0.0 1.8 2 0 0 2 2 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fer4_2 PF12797.2 KOO33603.1 - 0.78 9.7 8.3 0.38 10.7 1.3 2.7 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_3 PF12798.2 KOO33603.1 - 0.98 10.1 10.5 9.8 7.0 1.9 3.1 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_4 PF12800.2 KOO33603.1 - 6.3 7.4 9.5 0.61 10.5 1.4 2.7 2 0 0 2 2 2 0 4Fe-4S binding domain Pkinase PF00069.20 KOO33604.1 - 4.6e-69 232.4 0.0 6e-69 232.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33604.1 - 1.2e-33 116.2 0.0 2.9e-33 115.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.21 KOO33604.1 - 2.5e-13 49.9 0.2 4.2e-13 49.1 0.2 1.4 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.1 KOO33604.1 - 0.00035 19.6 0.0 0.0005 19.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 KOO33604.1 - 0.013 14.8 0.0 0.14 11.4 0.0 2.1 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL RIO1 PF01163.17 KOO33604.1 - 0.024 14.0 0.0 0.043 13.1 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.9 KOO33604.1 - 0.072 12.1 0.1 0.16 11.0 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family PH PF00169.24 KOO33605.1 - 0.001 19.2 0.0 0.0017 18.5 0.0 1.3 1 0 0 1 1 1 1 PH domain SH3_9 PF14604.1 KOO33605.1 - 0.01 15.4 0.0 0.025 14.1 0.0 1.7 2 0 0 2 2 2 0 Variant SH3 domain TPR_11 PF13414.1 KOO33606.1 - 2.1e-07 30.5 0.1 3.8e-07 29.6 0.1 1.4 1 0 0 1 1 1 1 TPR repeat TPR_12 PF13424.1 KOO33606.1 - 9.6e-05 22.2 0.2 0.0002 21.2 0.1 1.5 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO33606.1 - 0.00049 19.7 1.8 0.4 10.7 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO33606.1 - 0.002 17.6 2.3 0.26 10.9 0.2 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO33606.1 - 0.044 14.1 0.0 0.087 13.1 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat WD40 PF00400.27 KOO33608.1 - 1.2e-25 88.4 13.7 1.3e-07 31.2 0.0 8.2 8 0 0 8 8 8 6 WD domain, G-beta repeat EF-hand_8 PF13833.1 KOO33608.1 - 9.5e-06 25.1 0.0 1.8e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO33608.1 - 1.6e-05 24.4 0.4 6.8e-05 22.4 0.2 2.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 KOO33608.1 - 0.00013 21.0 0.1 0.00049 19.1 0.0 2.1 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.1 KOO33608.1 - 0.00013 21.1 0.1 0.00044 19.4 0.0 2.0 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO33608.1 - 0.00026 21.0 0.0 0.00098 19.2 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair PQQ_2 PF13360.1 KOO33608.1 - 0.00035 20.1 0.5 0.097 12.1 0.0 3.0 3 0 0 3 3 3 1 PQQ-like domain Ricin_B_lectin PF00652.17 KOO33608.1 - 0.2 11.6 0.2 1.3 9.1 0.0 2.4 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain Abhydrolase_6 PF12697.2 KOO33609.1 - 5.8e-18 65.5 1.4 6.5e-18 65.4 1.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO33609.1 - 6.4e-11 42.1 0.0 7.5e-11 41.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO33609.1 - 2.3e-09 37.1 0.0 2.4e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.5 KOO33609.1 - 1.7e-06 27.8 0.0 2.6e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein Peptidase_S9 PF00326.16 KOO33609.1 - 0.00023 20.4 0.0 0.00026 20.3 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.8 KOO33609.1 - 0.0021 17.5 0.0 0.0024 17.3 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Ser_hydrolase PF06821.8 KOO33609.1 - 0.0024 17.5 0.0 0.0027 17.3 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase LIP PF03583.9 KOO33609.1 - 0.0028 16.8 0.0 0.0036 16.5 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase Abhydrolase_2 PF02230.11 KOO33609.1 - 0.0058 16.1 0.0 0.0073 15.7 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Ndr PF03096.9 KOO33609.1 - 0.015 13.8 0.0 0.019 13.4 0.0 1.1 1 0 0 1 1 1 0 Ndr family DLH PF01738.13 KOO33609.1 - 0.077 12.2 0.0 0.089 12.0 0.0 1.1 1 0 0 1 1 1 0 Dienelactone hydrolase family bPH_6 PF10756.4 KOO33609.1 - 1.3 8.9 6.8 2.9 7.8 2.2 2.7 2 1 0 2 2 2 0 Bacterial PH domain BRO1 PF03097.13 KOO33610.1 - 7.5e-59 199.3 0.0 1e-58 198.9 0.0 1.1 1 0 0 1 1 1 1 BRO1-like domain UBA PF00627.26 KOO33610.1 - 2.6e-05 23.8 0.1 5.8e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain MIF4G PF02854.14 KOO33610.1 - 0.18 11.2 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 MIF4G domain Adeno_Penton_B PF01686.12 KOO33610.1 - 0.27 9.4 1.7 0.41 8.8 1.2 1.1 1 0 0 1 1 1 0 Adenovirus penton base protein Dpy-30 PF05186.8 KOO33613.1 - 0.1 12.0 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Dpy-30 motif Ammonium_transp PF00909.16 KOO33614.1 - 2.9e-109 365.1 29.4 3.5e-109 364.9 20.4 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family PP2C PF00481.16 KOO33615.1 - 8.2e-20 71.2 0.0 1.3e-19 70.6 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C Ank PF00023.25 KOO33615.1 - 2.4e-18 64.9 5.4 3.7e-06 26.4 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.2 KOO33615.1 - 1e-16 61.0 1.1 2.7e-16 59.6 0.7 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO33615.1 - 3.4e-10 40.1 1.2 2.6e-05 24.6 0.1 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO33615.1 - 1.4e-08 34.6 3.1 3.9e-05 23.7 0.3 3.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO33615.1 - 4.7e-08 32.5 2.2 0.056 13.6 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat SpoIIE PF07228.7 KOO33615.1 - 2e-06 27.6 3.6 0.00011 21.9 0.7 2.8 3 0 0 3 3 3 2 Stage II sporulation protein E (SpoIIE) Asparaginase_2 PF01112.13 KOO33616.1 - 1.1e-58 198.5 0.4 1.4e-58 198.1 0.3 1.1 1 0 0 1 1 1 1 Asparaginase G_glu_transpept PF01019.16 KOO33616.1 - 0.01 14.3 0.0 0.014 13.9 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Big_3_4 PF13754.1 KOO33616.1 - 0.08 13.2 0.1 0.14 12.4 0.1 1.4 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) Cation_efflux PF01545.16 KOO33617.1 - 2.8e-18 65.9 8.8 1.6e-12 47.0 0.6 2.0 2 0 0 2 2 2 2 Cation efflux family DctQ PF04290.7 KOO33617.1 - 0.0064 16.2 2.5 0.016 15.0 0.7 2.0 2 0 0 2 2 2 1 Tripartite ATP-independent periplasmic transporters, DctQ component DUF2076 PF09849.4 KOO33617.1 - 0.14 12.1 0.2 0.19 11.7 0.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Chloroa_b-bind PF00504.16 KOO33618.1 - 3.4e-30 105.3 0.0 4.5e-30 104.9 0.0 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein DnaJ PF00226.26 KOO33619.1 - 7.7e-06 25.5 0.3 8.2e-05 22.2 0.0 2.7 3 0 0 3 3 3 1 DnaJ domain NapB PF03892.9 KOO33619.1 - 0.59 9.8 0.1 0.59 9.8 0.0 2.3 1 1 1 2 2 2 0 Nitrate reductase cytochrome c-type subunit (NapB) DNA_pol_viral_N PF00242.12 KOO33619.1 - 6.3 5.7 9.7 7.8 5.4 6.3 1.3 1 1 0 1 1 1 0 DNA polymerase (viral) N-terminal domain EF-hand_7 PF13499.1 KOO33621.1 - 8.5e-12 45.0 5.2 1.7e-06 28.0 1.2 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO33621.1 - 3.6e-10 38.8 4.7 0.0071 16.1 0.2 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.27 KOO33621.1 - 1.2e-09 36.7 15.8 0.002 17.2 0.5 3.4 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 KOO33621.1 - 2.4e-09 36.6 12.0 3.8e-07 29.6 0.7 3.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO33621.1 - 7.3e-05 21.9 4.8 0.14 11.5 0.1 3.5 3 0 0 3 3 3 2 EF hand cNMP_binding PF00027.24 KOO33622.1 - 0.00033 20.4 0.0 0.00092 18.9 0.0 1.8 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain AMP-binding PF00501.23 KOO33624.1 - 1.7e-89 300.1 0.0 2.2e-89 299.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 KOO33624.1 - 0.0092 16.9 0.1 0.033 15.1 0.0 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Sbi-IV PF11621.3 KOO33624.1 - 0.33 11.1 2.0 0.4 10.8 0.0 2.1 3 0 0 3 3 3 0 C3 binding domain 4 of IgG-bind protein SBI Kinesin PF00225.18 KOO33626.1 - 1.2e-95 320.0 0.0 2.3e-95 319.1 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain ERM PF00769.14 KOO33626.1 - 0.0038 16.8 13.4 0.0038 16.8 9.3 3.2 3 0 0 3 3 3 1 Ezrin/radixin/moesin family OmpH PF03938.9 KOO33626.1 - 0.0049 16.8 6.8 0.0049 16.8 4.7 3.2 3 0 0 3 3 3 2 Outer membrane protein (OmpH-like) AAA_13 PF13166.1 KOO33626.1 - 0.15 10.4 9.1 0.11 10.8 1.3 2.5 2 0 0 2 2 2 0 AAA domain IncA PF04156.9 KOO33626.1 - 0.37 10.3 31.4 0.053 13.1 3.2 3.1 3 0 0 3 3 3 0 IncA protein JAB PF01398.16 KOO33627.1 - 1.6e-33 114.8 0.0 3.5e-33 113.7 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.1 KOO33627.1 - 1.3e-25 89.6 4.0 3e-25 88.5 2.7 1.6 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.1 KOO33627.1 - 4.8e-07 29.2 0.0 1e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Phasin PF05597.6 KOO33627.1 - 0.047 13.4 1.9 0.096 12.4 1.1 1.6 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) CIA30 PF08547.7 KOO33628.1 - 1.3e-32 112.7 0.0 1.5e-32 112.6 0.0 1.0 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) Dpy-30 PF05186.8 KOO33630.1 - 0.0073 15.7 0.3 0.023 14.1 0.2 1.9 1 0 0 1 1 1 1 Dpy-30 motif Exo_endo_phos PF03372.18 KOO33632.1 - 0.00021 21.3 0.0 0.00031 20.7 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family EF-hand_5 PF13202.1 KOO33633.1 - 0.013 14.7 0.0 0.027 13.8 0.0 1.5 1 0 0 1 1 1 0 EF hand Pkinase PF00069.20 KOO33634.1 - 1.7e-57 194.5 0.1 2.1e-36 125.3 0.0 2.3 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33634.1 - 7.4e-30 103.8 2.7 1.5e-22 79.8 0.0 2.9 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.1 KOO33634.1 - 0.00023 20.2 0.1 0.014 14.3 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 KOO33634.1 - 0.00052 19.8 0.2 0.52 9.9 0.1 2.7 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_C PF00433.19 KOO33634.1 - 0.0016 18.8 0.1 0.0033 17.9 0.1 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Glyco_transf_34 PF05637.7 KOO33635.1 - 2.4e-26 92.7 0.0 8.9e-25 87.5 0.0 2.5 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Nucleotid_trans PF03407.11 KOO33635.1 - 0.00019 21.2 0.0 0.00031 20.6 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase DUF706 PF05153.10 KOO33638.1 - 6.4e-11 42.0 0.1 1.4e-06 27.8 0.1 3.3 2 1 0 2 2 2 2 Family of unknown function (DUF706) PAT1 PF09770.4 KOO33638.1 - 9.4 4.3 8.5 14 3.7 5.9 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CIA30 PF08547.7 KOO33639.1 - 3e-22 79.1 0.0 3.4e-22 78.9 0.0 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) Phage-scaffold PF09306.5 KOO33639.1 - 0.15 11.1 0.0 0.21 10.7 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage, scaffolding protein Glyco_transf_8 PF01501.15 KOO33640.1 - 8.5e-07 28.5 0.0 3.5e-06 26.5 0.0 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 8 Ribosomal_L12 PF00542.14 KOO33642.1 - 5.5e-22 77.5 3.7 6.1e-22 77.3 2.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L7/L12 C-terminal domain DUF2191 PF09957.4 KOO33642.1 - 0.073 12.8 0.1 0.09 12.5 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2191) MgtE PF01769.11 KOO33644.1 - 3.6e-13 49.9 4.0 4.9e-13 49.5 2.8 1.2 1 0 0 1 1 1 1 Divalent cation transporter FSH1 PF03959.8 KOO33645.1 - 7.8e-24 84.3 0.0 1.2e-23 83.6 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Pkinase PF00069.20 KOO33646.1 - 6.1e-39 133.7 0.0 6.8e-39 133.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33646.1 - 3e-18 65.8 0.0 3.8e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO33646.1 - 1.6e-05 24.8 1.0 5.1e-05 23.1 0.0 2.4 2 2 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.9 KOO33646.1 - 0.011 14.7 0.0 0.019 14.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CBM_19 PF03427.8 KOO33646.1 - 0.1 12.4 0.0 0.26 11.1 0.0 1.7 1 0 0 1 1 1 0 Carbohydrate binding domain (family 19) Myosin_head PF00063.16 KOO33649.1 - 6.9e-186 619.3 0.0 3.5e-184 613.6 0.0 2.2 1 1 0 1 1 1 1 Myosin head (motor domain) PDZ PF00595.19 KOO33649.1 - 2.2e-19 69.3 7.3 4.9e-07 29.8 0.1 3.7 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO33649.1 - 3.2e-15 55.7 3.0 0.00032 20.5 0.0 3.6 3 0 0 3 3 3 3 PDZ domain WW PF00397.21 KOO33649.1 - 9.5e-05 22.1 1.4 0.0002 21.1 1.0 1.5 1 0 0 1 1 1 1 WW domain AAA_22 PF13401.1 KOO33649.1 - 0.014 15.5 0.0 0.087 12.9 0.0 2.3 3 0 0 3 3 3 0 AAA domain Hpr_kinase_C PF07475.7 KOO33649.1 - 0.071 12.4 0.1 0.16 11.2 0.1 1.6 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain AAA_18 PF13238.1 KOO33649.1 - 0.13 12.5 0.0 0.4 10.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain Alpha_kinase PF02816.13 KOO33650.1 - 7.1e-38 130.1 3.3 5.3e-19 68.6 0.1 2.1 2 0 0 2 2 2 2 Alpha-kinase family DUF1378 PF07125.6 KOO33650.1 - 0.054 13.4 1.9 0.098 12.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1378) Ras PF00071.17 KOO33651.1 - 3.2e-63 211.9 0.3 3.9e-63 211.6 0.2 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO33651.1 - 3.7e-20 72.6 0.0 5.9e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO33651.1 - 6.6e-14 51.5 0.1 8.3e-14 51.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 KOO33651.1 - 8.3e-06 25.7 0.0 1.4e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 KOO33651.1 - 2.2e-05 23.7 0.1 2.7e-05 23.4 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KOO33651.1 - 0.00066 19.1 0.1 0.0023 17.3 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 KOO33651.1 - 0.0045 17.1 0.1 0.028 14.5 0.1 2.1 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 KOO33651.1 - 0.012 14.8 0.1 0.043 13.0 0.0 1.8 2 1 0 2 2 2 0 Protein of unknown function, DUF258 SRPRB PF09439.5 KOO33651.1 - 0.049 12.8 0.0 0.088 12.0 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Pik1 PF11522.3 KOO33651.1 - 0.098 12.4 0.1 0.17 11.6 0.1 1.4 1 0 0 1 1 1 0 Yeast phosphatidylinositol-4-OH kinase Pik1 AAA_16 PF13191.1 KOO33651.1 - 0.12 12.3 0.1 0.31 11.0 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain DUF3456 PF11938.3 KOO33652.1 - 0.0027 17.7 3.8 0.12 12.3 0.3 2.6 1 1 1 2 2 2 2 TLR4 regulator and MIR-interacting MSAP LLC1 PF14945.1 KOO33653.1 - 7.3e-07 29.5 0.2 7.5e-07 29.4 0.2 1.1 1 0 0 1 1 1 1 Normal lung function maintenance, Low in Lung Cancer 1 protein ARPC4 PF05856.7 KOO33654.1 - 3e-69 231.7 3.0 3.4e-69 231.5 2.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Fe-S_biosyn PF01521.15 KOO33655.1 - 1.7e-14 53.6 0.0 2.1e-14 53.3 0.0 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis BTB PF00651.26 KOO33657.1 - 1e-14 54.4 0.0 2.1e-14 53.4 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Nop14 PF04147.7 KOO33657.1 - 1.6 6.5 7.8 2.1 6.1 5.4 1.1 1 0 0 1 1 1 0 Nop14-like family Glutaredoxin PF00462.19 KOO33658.1 - 2.2e-16 59.5 0.1 4e-16 58.7 0.0 1.4 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin_2 PF13098.1 KOO33658.1 - 0.0011 19.1 0.1 0.0022 18.1 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_4 PF13462.1 KOO33658.1 - 0.027 14.4 0.3 6.5 6.7 0.1 2.1 1 1 1 2 2 2 0 Thioredoxin Ion_trans PF00520.26 KOO33659.1 - 2.8e-168 555.5 42.5 5.7e-49 166.0 0.1 4.3 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 KOO33659.1 - 1e-07 30.7 46.2 0.002 16.6 1.4 8.5 6 4 2 8 8 8 5 Polycystin cation channel Methyltransf_21 PF05050.7 KOO33660.1 - 0.061 13.2 0.0 0.35 10.7 0.0 1.8 1 1 0 2 2 2 0 Methyltransferase FkbM domain SPOUT_MTase PF02590.12 KOO33660.1 - 0.15 11.7 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 Predicted SPOUT methyltransferase EF-hand_5 PF13202.1 KOO33661.1 - 5.2e-10 38.2 0.4 0.00016 20.8 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO33661.1 - 1.1e-09 38.2 0.1 0.00021 21.3 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO33661.1 - 2e-09 36.5 0.2 0.00024 20.7 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO33661.1 - 5e-09 34.8 0.0 0.00049 19.2 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO33661.1 - 4.5e-05 22.9 0.0 0.0001 21.8 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair Drf_FH3 PF06367.11 KOO33662.1 - 5e-13 48.9 0.2 1.6e-12 47.2 0.2 1.7 1 1 0 1 1 1 1 Diaphanous FH3 Domain WGR PF05406.10 KOO33663.1 - 4.9e-14 52.0 0.0 9.6e-14 51.1 0.0 1.4 1 0 0 1 1 1 1 WGR domain WWE PF02825.15 KOO33663.1 - 4e-08 32.5 0.2 6.4e-08 31.9 0.1 1.3 1 0 0 1 1 1 1 WWE domain Topo_Zn_Ribbon PF08272.6 KOO33663.1 - 0.35 10.2 2.0 0.72 9.2 0.6 2.1 2 0 0 2 2 2 0 Topoisomerase I zinc-ribbon-like PH PF00169.24 KOO33664.1 - 1.1e-08 35.1 0.0 4.9e-08 33.1 0.0 1.9 1 1 0 1 1 1 1 PH domain PH_11 PF15413.1 KOO33664.1 - 8e-08 32.5 0.1 6e-07 29.7 0.0 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.1 KOO33664.1 - 0.012 15.6 0.1 0.051 13.6 0.0 2.1 3 0 0 3 3 3 0 Pleckstrin homology domain PARP PF00644.15 KOO33665.1 - 2.8e-08 33.4 0.0 3.3e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Con-6 PF10346.4 KOO33667.1 - 0.16 11.3 4.0 11 5.5 0.0 4.1 2 2 2 4 4 4 0 Conidiation protein 6 WD40 PF00400.27 KOO33668.1 - 3.8e-36 121.6 8.2 5.8e-09 35.4 0.4 6.6 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.3 KOO33668.1 - 0.28 9.2 2.8 3.8 5.5 0.1 3.2 1 1 1 4 4 4 0 Nucleoporin Nup120/160 SnAC PF14619.1 KOO33669.1 - 0.0023 18.0 1.1 0.0053 16.8 0.7 1.6 1 0 0 1 1 1 1 Snf2-ATP coupling, chromatin remodelling complex DNA_pol_phi PF04931.8 KOO33669.1 - 0.35 8.6 5.2 0.48 8.1 3.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi STAG PF08514.6 KOO33670.1 - 7.7e-16 57.8 0.0 1.5e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 STAG domain HEAT PF02985.17 KOO33670.1 - 0.69 10.1 11.1 17 5.8 0.0 5.4 6 0 0 6 6 6 0 HEAT repeat ABC1 PF03109.11 KOO33671.1 - 9e-26 90.1 0.0 1.4e-25 89.5 0.0 1.3 1 0 0 1 1 1 1 ABC1 family RNB PF00773.14 KOO33672.1 - 1.5e-57 195.3 0.0 6.1e-42 144.0 0.0 2.2 1 1 1 2 2 2 2 RNB domain MMR_HSR1 PF01926.18 KOO33672.1 - 0.02 14.8 0.1 0.086 12.8 0.0 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_16 PF13191.1 KOO33672.1 - 0.035 14.1 0.2 0.035 14.1 0.1 2.3 3 0 0 3 3 3 0 AAA ATPase domain AAA_17 PF13207.1 KOO33672.1 - 0.071 13.9 0.6 0.28 12.0 0.4 2.0 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 KOO33672.1 - 0.077 13.1 0.1 0.14 12.3 0.1 1.4 1 0 0 1 1 1 0 RNA helicase DUF258 PF03193.11 KOO33672.1 - 0.2 10.8 0.5 2 7.6 0.4 2.1 1 1 0 1 1 1 0 Protein of unknown function, DUF258 KH_1 PF00013.24 KOO33673.1 - 2.5e-10 39.8 0.0 4.5e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 KOO33673.1 - 8.7e-08 31.6 0.0 1.8e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 KH domain KH_4 PF13083.1 KOO33673.1 - 0.012 15.1 0.0 0.027 14.1 0.0 1.6 1 0 0 1 1 1 0 KH domain KH_2 PF07650.12 KOO33673.1 - 0.015 14.8 0.0 0.024 14.1 0.0 1.3 1 0 0 1 1 1 0 KH domain ARL2_Bind_BART PF11527.3 KOO33674.1 - 2.5e-07 30.5 0.3 3.5e-07 30.0 0.2 1.2 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART TPT PF03151.11 KOO33675.1 - 1.7e-13 50.4 5.1 3.7e-13 49.3 3.5 1.6 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.15 KOO33675.1 - 3.5e-09 36.7 20.8 5.8e-07 29.5 3.1 3.0 3 1 0 3 3 3 2 EamA-like transporter family UAA PF08449.6 KOO33675.1 - 0.0094 14.8 6.5 0.046 12.6 4.5 2.0 1 1 0 1 1 1 1 UAA transporter family Brevenin PF03032.10 KOO33675.1 - 0.12 12.2 0.0 0.37 10.6 0.0 1.8 1 0 0 1 1 1 0 Brevenin/esculentin/gaegurin/rugosin family Arf PF00025.16 KOO33676.1 - 1.2e-68 229.7 0.0 1.6e-68 229.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 KOO33676.1 - 5.7e-13 48.5 0.0 7e-13 48.2 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 KOO33676.1 - 5.4e-12 45.3 0.0 6.7e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 KOO33676.1 - 3.9e-10 38.9 0.3 2e-06 26.7 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Miro PF08477.8 KOO33676.1 - 9.3e-10 39.0 0.0 1.4e-09 38.4 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Gtr1_RagA PF04670.7 KOO33676.1 - 2.7e-09 36.5 0.0 3.5e-09 36.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 KOO33676.1 - 7.7e-06 25.8 0.0 1.1e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.7 KOO33676.1 - 0.0099 15.5 0.1 0.023 14.3 0.1 1.8 1 1 0 1 1 1 1 NACHT domain 6PF2K PF01591.13 KOO33676.1 - 0.077 12.0 0.0 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_33 PF13671.1 KOO33676.1 - 0.13 12.1 0.1 0.21 11.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain GTP_EFTU PF00009.22 KOO33676.1 - 0.16 11.3 0.1 1 8.7 0.0 1.9 1 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Alg14 PF08660.6 KOO33678.1 - 1.1e-61 207.7 0.0 1.2e-61 207.6 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like Ank_2 PF12796.2 KOO33679.1 - 3.7e-32 110.5 3.4 8.9e-18 64.4 0.6 2.6 2 1 1 3 3 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO33679.1 - 1.3e-17 62.5 0.0 3.3e-07 29.7 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 KOO33679.1 - 8.2e-14 51.3 0.3 1.3e-07 31.6 0.1 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO33679.1 - 2.7e-12 46.8 0.4 1.3e-05 25.5 0.0 3.1 3 0 0 3 3 2 2 Ankyrin repeats (many copies) EF-hand_6 PF13405.1 KOO33679.1 - 1.4e-10 40.1 2.8 0.00024 20.7 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO33679.1 - 2.2e-10 39.0 1.8 8.5e-05 21.5 0.1 2.8 2 0 0 2 2 2 2 EF hand Ank_3 PF13606.1 KOO33679.1 - 3.5e-10 39.0 0.1 5.8e-05 22.9 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat EF-hand_8 PF13833.1 KOO33679.1 - 1.6e-08 34.0 0.1 4.6e-08 32.5 0.1 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.1 KOO33679.1 - 1.2e-07 31.7 1.1 5.1e-07 29.7 0.7 2.1 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO33679.1 - 2.8e-06 26.4 3.4 0.0018 17.5 0.2 2.5 2 0 0 2 2 2 2 EF hand ADPrib_exo_Tox PF03496.9 KOO33679.1 - 0.00022 20.5 0.0 0.00046 19.4 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme ART PF01129.13 KOO33679.1 - 0.00031 19.9 0.0 0.00072 18.7 0.0 1.6 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase DUF1778 PF08681.6 KOO33679.1 - 6.7 6.6 9.7 0.66 9.8 0.3 3.0 3 0 0 3 3 2 0 Protein of unknown function (DUF1778) Cystatin PF00031.16 KOO33680.1 - 7.5e-05 22.7 0.1 0.00019 21.5 0.0 1.7 1 0 0 1 1 1 1 Cystatin domain zf-DHHC PF01529.15 KOO33681.1 - 2.3e-16 59.6 0.0 5.5e-16 58.4 0.0 1.6 1 1 0 1 1 1 1 DHHC palmitoyltransferase Abhydrolase_5 PF12695.2 KOO33682.1 - 4.6e-15 55.6 0.5 6.8e-15 55.0 0.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 KOO33682.1 - 1.8e-08 33.5 0.0 2.6e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_6 PF12697.2 KOO33682.1 - 1.3e-07 31.7 0.8 0.002 18.0 0.2 2.3 1 1 1 2 2 2 2 Alpha/beta hydrolase family Chlorophyllase PF07224.6 KOO33682.1 - 9.9e-07 27.8 0.1 1.4e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase Abhydrolase_3 PF07859.8 KOO33682.1 - 5.9e-05 22.7 0.2 8.9e-05 22.1 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold PAF-AH_p_II PF03403.8 KOO33682.1 - 6.8e-05 21.3 0.2 0.039 12.2 0.0 2.1 2 0 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Peptidase_S9 PF00326.16 KOO33682.1 - 0.00049 19.3 0.6 0.63 9.2 0.0 2.3 1 1 1 2 2 2 2 Prolyl oligopeptidase family Esterase PF00756.15 KOO33682.1 - 0.00061 19.2 0.9 0.0013 18.2 0.4 1.6 2 0 0 2 2 2 1 Putative esterase Lipase_3 PF01764.20 KOO33682.1 - 0.0012 18.5 0.3 0.002 17.7 0.2 1.3 1 0 0 1 1 1 1 Lipase (class 3) DLH PF01738.13 KOO33682.1 - 0.031 13.5 0.1 0.047 12.9 0.1 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family DUF2974 PF11187.3 KOO33682.1 - 0.04 13.2 0.3 0.061 12.6 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) DUF3584 PF12128.3 KOO33683.1 - 2.1 5.5 60.7 0.58 7.4 6.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) DUF2188 PF09954.4 KOO33684.1 - 0.13 12.1 6.3 0.28 11.1 4.4 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2188) Lactamase_B PF00753.22 KOO33685.1 - 2.9e-25 89.0 0.3 5.3e-25 88.2 0.2 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Rhodanese PF00581.15 KOO33685.1 - 0.0015 18.8 0.0 0.0033 17.7 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Lactamase_B_2 PF12706.2 KOO33685.1 - 0.0082 15.7 0.1 0.013 15.1 0.0 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain PB1 PF00564.19 KOO33686.1 - 0.047 13.3 0.0 0.064 12.9 0.0 1.2 1 0 0 1 1 1 0 PB1 domain AUX_IAA PF02309.11 KOO33686.1 - 0.28 10.9 0.1 0.28 10.9 0.1 2.0 1 1 1 2 2 2 0 AUX/IAA family Lipase_GDSL_2 PF13472.1 KOO33687.1 - 0.086 12.9 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Mito_carr PF00153.22 KOO33688.1 - 2.5e-44 148.8 4.3 5.3e-16 58.1 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein PC-Esterase PF13839.1 KOO33689.1 - 0.039 13.7 0.0 0.085 12.6 0.0 1.6 2 0 0 2 2 2 0 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p OmpH PF03938.9 KOO33690.1 - 0.012 15.5 1.9 0.013 15.4 1.3 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4440 PF14534.1 KOO33690.1 - 0.21 11.8 1.1 7.1 6.8 0.2 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4440) EF-hand_7 PF13499.1 KOO33691.1 - 2.2e-12 46.9 0.2 1.5e-11 44.2 0.1 2.5 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO33691.1 - 4.2e-06 25.6 0.2 0.0053 15.9 0.1 3.6 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO33691.1 - 6.1e-06 25.6 1.4 0.0032 17.2 0.1 3.8 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.1 KOO33691.1 - 0.02 14.4 1.2 10 5.8 0.0 3.5 3 0 0 3 3 3 0 EF-hand domain pair EF-hand_5 PF13202.1 KOO33691.1 - 0.057 12.7 0.1 0.53 9.7 0.0 2.5 2 0 0 2 2 2 0 EF hand LRR_6 PF13516.1 KOO33692.1 - 9.6e-27 90.0 29.0 0.0068 16.3 0.0 14.3 15 0 0 15 15 15 8 Leucine Rich repeat LRR_4 PF12799.2 KOO33692.1 - 1.1e-09 37.7 0.9 1.5 8.4 0.0 8.2 5 3 4 9 9 9 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO33692.1 - 2.2e-09 36.9 12.5 0.073 12.8 0.7 8.1 4 2 4 8 8 8 4 Leucine rich repeat LRR_1 PF00560.28 KOO33692.1 - 5.2e-08 31.8 14.6 8.2 6.8 0.0 11.1 10 4 1 11 11 11 1 Leucine Rich Repeat LRR_7 PF13504.1 KOO33692.1 - 1.2e-05 24.7 35.4 20 5.9 0.0 13.7 14 1 0 14 14 14 1 Leucine rich repeat F-box PF00646.28 KOO33692.1 - 0.68 9.6 0.0 0.68 9.6 0.0 3.5 3 0 0 3 3 3 0 F-box domain La PF05383.12 KOO33693.1 - 7.8e-23 80.0 0.0 1.1e-22 79.5 0.0 1.2 1 0 0 1 1 1 1 La domain DUF3223 PF11523.3 KOO33693.1 - 2.3e-18 66.2 0.0 4.9e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3223) RRM_3 PF08777.6 KOO33693.1 - 0.0018 18.0 0.1 0.014 15.2 0.0 2.3 1 1 0 1 1 1 1 RNA binding motif Barttin PF15462.1 KOO33693.1 - 0.12 12.0 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) GRP PF07172.6 KOO33693.1 - 0.74 10.3 29.9 3.1 8.3 12.9 2.6 2 0 0 2 2 2 0 Glycine rich protein family Cupin_4 PF08007.7 KOO33694.1 - 2.7e-59 200.9 0.0 4.6e-59 200.2 0.0 1.4 2 0 0 2 2 2 1 Cupin superfamily protein Cupin_8 PF13621.1 KOO33694.1 - 0.001 18.6 0.1 0.02 14.3 0.1 2.2 1 1 0 1 1 1 1 Cupin-like domain AraC_binding PF02311.14 KOO33694.1 - 0.041 13.5 0.0 0.18 11.5 0.0 2.0 2 0 0 2 2 2 0 AraC-like ligand binding domain TPR_12 PF13424.1 KOO33695.1 - 2.6e-05 24.0 6.0 0.025 14.4 0.1 3.6 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.1 KOO33695.1 - 0.021 14.7 4.4 0.044 13.7 0.3 3.4 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF2365 PF10157.4 KOO33695.1 - 0.053 13.4 1.4 0.13 12.1 0.1 2.3 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2365) LRR_4 PF12799.2 KOO33697.1 - 1.5e-27 94.6 15.5 0.0015 18.1 0.0 7.6 6 1 1 7 7 7 7 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO33697.1 - 2.6e-27 91.7 45.6 0.0098 15.8 0.4 13.6 14 0 0 14 14 14 8 Leucine Rich repeat LRR_7 PF13504.1 KOO33697.1 - 3.2e-12 44.5 26.5 15 6.3 0.1 13.2 13 0 0 13 13 13 2 Leucine rich repeat LRR_1 PF00560.28 KOO33697.1 - 4.5e-12 44.2 0.7 33 5.0 0.1 11.7 13 0 0 13 13 13 0 Leucine Rich Repeat LRR_8 PF13855.1 KOO33697.1 - 3.6e-06 26.6 31.1 0.33 10.7 2.2 7.2 1 1 10 11 11 11 10 Leucine rich repeat DUF4030 PF13222.1 KOO33697.1 - 0.0019 17.9 0.8 66 3.1 0.0 5.1 3 1 3 6 6 6 0 Protein of unknown function (DUF4030) LRR_2 PF07723.8 KOO33697.1 - 0.018 15.5 1.0 1.8e+02 2.8 0.0 5.4 6 0 0 6 6 6 0 Leucine Rich Repeat HrpB2 PF09487.5 KOO33697.1 - 0.029 14.5 8.0 32 4.7 0.1 5.0 4 1 0 5 5 5 0 Bacterial type III secretion protein (HrpB2) FAD_oxidored PF12831.2 KOO33697.1 - 0.1 11.6 7.3 43 2.9 0.0 4.7 5 0 0 5 5 5 0 FAD dependent oxidoreductase Mago_nashi PF02792.9 KOO33698.1 - 0.11 12.2 0.1 0.11 12.1 0.1 1.1 1 0 0 1 1 1 0 Mago nashi protein DUF2457 PF10446.4 KOO33698.1 - 1.5 7.4 6.5 1.6 7.4 4.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Filamin PF00630.14 KOO33699.1 - 6.9e-26 90.7 0.0 7.8e-06 26.3 0.0 4.5 4 0 0 4 4 4 4 Filamin/ABP280 repeat EF-hand_1 PF00036.27 KOO33700.1 - 5.1e-16 56.6 2.4 2.2e-07 29.7 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO33700.1 - 4.1e-12 46.0 0.1 1.1e-11 44.6 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO33700.1 - 3e-10 38.9 0.6 2.8e-05 23.2 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO33700.1 - 3.6e-10 38.8 0.5 3.1e-05 23.4 0.2 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO33700.1 - 2.7e-09 36.4 3.8 4.7e-05 22.9 0.2 2.5 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO33700.1 - 0.0038 17.2 0.0 0.0038 17.2 0.0 3.8 3 1 1 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOO33700.1 - 0.0068 16.2 0.1 0.016 15.1 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.2 KOO33700.1 - 0.0079 15.9 0.4 0.0079 15.9 0.3 2.3 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO33700.1 - 0.0087 15.7 0.1 0.036 13.7 0.1 2.1 1 0 0 1 1 1 1 EF hand Arm PF00514.18 KOO33701.1 - 3.4e-06 26.6 5.9 0.0015 18.2 0.0 3.9 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat SEN1_N PF12726.2 KOO33701.1 - 0.26 9.3 0.1 1.1 7.1 0.0 1.8 2 0 0 2 2 2 0 SEN1 N terminal PCMT PF01135.14 KOO33702.1 - 1.6e-25 89.8 0.0 2.4e-25 89.3 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 KOO33702.1 - 2.2e-08 33.8 0.0 5.7e-08 32.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO33702.1 - 2e-05 25.1 0.0 4.2e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOO33702.1 - 0.0013 18.0 0.0 0.0027 17.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.1 KOO33702.1 - 0.0024 17.5 0.0 0.0045 16.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO33702.1 - 0.0035 17.3 3.9 0.02 14.8 2.7 2.4 1 1 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.15 KOO33702.1 - 0.0098 14.9 0.0 0.014 14.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase DOT1 PF08123.8 KOO33702.1 - 0.022 14.0 0.0 0.034 13.4 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_11 PF08241.7 KOO33702.1 - 0.062 13.8 0.0 0.18 12.2 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Sigma70_ner PF04546.8 KOO33702.1 - 0.22 11.1 4.4 0.39 10.2 3.1 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region Pyrid_oxidase_2 PF13883.1 KOO33703.1 - 2.1e-47 161.0 0.0 1.3e-28 99.8 0.0 2.1 2 0 0 2 2 2 2 Pyridoxamine 5'-phosphate oxidase Beta_propel PF09826.4 KOO33704.1 - 1.3e-108 363.6 0.0 3.2e-89 299.6 0.0 2.0 1 1 1 2 2 2 2 Beta propeller domain Myosin_tail_1 PF01576.14 KOO33705.1 - 0.00071 17.4 15.0 0.00071 17.4 10.4 2.9 1 1 2 3 3 3 1 Myosin tail Reo_sigmaC PF04582.7 KOO33705.1 - 0.072 12.2 4.3 0.13 11.3 0.6 2.4 2 1 0 2 2 2 0 Reovirus sigma C capsid protein Filament PF00038.16 KOO33705.1 - 0.69 9.3 26.9 1.4 8.2 5.0 4.1 2 1 1 3 3 3 0 Intermediate filament protein Birna_RdRp PF04197.7 KOO33705.1 - 1.8 6.5 10.5 2.6 5.9 7.3 1.2 1 0 0 1 1 1 0 Birnavirus RNA dependent RNA polymerase (VP1) Spc7 PF08317.6 KOO33705.1 - 2.1 6.9 24.8 0.011 14.3 7.6 2.8 3 0 0 3 3 3 0 Spc7 kinetochore protein TPR_14 PF13428.1 KOO33706.1 - 3.7 8.4 10.2 5 8.0 0.1 4.0 2 1 1 3 3 3 0 Tetratricopeptide repeat RVT_1 PF00078.22 KOO33707.1 - 0.012 14.9 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Sec7_N PF12783.2 KOO33709.1 - 1.6e-18 66.7 0.0 1e-17 64.1 0.0 2.5 1 0 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.5 KOO33709.1 - 6.6e-11 41.5 0.2 1.5e-07 30.7 0.0 3.6 3 0 0 3 3 3 2 Domain of unknown function (DUF1981) Ribosomal_L5_C PF00673.16 KOO33710.1 - 3.7e-22 77.8 0.1 5.5e-22 77.3 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 KOO33710.1 - 2e-19 69.1 0.9 2.3e-18 65.7 0.1 2.3 2 0 0 2 2 2 1 Ribosomal protein L5 DUF4200 PF13863.1 KOO33711.1 - 2.3e-26 92.2 28.8 2.3e-26 92.2 20.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4200) adh_short PF00106.20 KOO33712.1 - 0.0028 17.5 1.4 0.0033 17.3 0.1 1.7 2 0 0 2 2 2 1 short chain dehydrogenase Glyco_transf_4 PF13439.1 KOO33712.1 - 0.0064 16.2 0.1 0.013 15.2 0.0 1.6 1 1 0 2 2 2 1 Glycosyltransferase Family 4 NAD_binding_7 PF13241.1 KOO33712.1 - 0.085 13.1 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.13 KOO33712.1 - 0.11 12.0 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glyco_trans_4_4 PF13579.1 KOO33712.1 - 2.5 8.2 9.5 27 4.8 6.5 2.2 1 1 0 1 1 1 0 Glycosyl transferase 4-like domain DUF218 PF02698.12 KOO33713.1 - 5.4e-21 74.6 0.0 1e-20 73.8 0.0 1.4 1 0 0 1 1 1 1 DUF218 domain LRR_6 PF13516.1 KOO33716.1 - 4e-24 81.9 32.3 0.1 12.7 0.1 16.4 18 0 0 18 18 18 8 Leucine Rich repeat LRR_1 PF00560.28 KOO33716.1 - 1.4e-07 30.5 14.6 4.6 7.6 0.0 11.7 14 0 0 14 14 14 1 Leucine Rich Repeat NACHT PF05729.7 KOO33716.1 - 1.2e-05 25.0 0.1 2.1e-05 24.2 0.1 1.4 1 0 0 1 1 1 1 NACHT domain LRR_4 PF12799.2 KOO33716.1 - 0.00019 20.9 28.3 0.27 10.9 0.1 8.6 8 2 0 8 8 8 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO33716.1 - 0.0013 18.4 18.3 11 5.8 0.5 8.3 7 2 0 7 7 7 2 Leucine rich repeat RRM_6 PF14259.1 KOO33716.1 - 0.0033 17.3 0.0 0.026 14.4 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOO33716.1 - 0.023 14.3 0.0 0.059 13.0 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LRR_7 PF13504.1 KOO33716.1 - 0.025 14.7 19.0 56 4.6 0.1 10.5 12 0 0 12 12 12 0 Leucine rich repeat DUF2853 PF11015.3 KOO33716.1 - 0.61 10.5 2.7 53 4.3 0.0 4.4 5 0 0 5 5 5 0 Protein of unknown function (DUF2853) FIBP PF05427.6 KOO33716.1 - 0.93 8.6 0.0 5 6.2 0.0 1.9 2 0 0 2 2 2 0 Acidic fibroblast growth factor binding (FIBP) DUF4460 PF14687.1 KOO33718.1 - 0.0035 17.0 0.1 0.0047 16.6 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4460) Peptidase_C74 PF12387.3 KOO33718.1 - 0.026 13.7 1.0 0.036 13.2 0.7 1.2 1 0 0 1 1 1 0 Pestivirus NS2 peptidase YrhK PF14145.1 KOO33719.1 - 7.2e-08 31.9 30.3 0.0062 16.1 4.6 3.5 2 1 1 3 3 3 3 YrhK-like protein ESSS PF10183.4 KOO33719.1 - 0.026 14.9 0.4 0.066 13.6 0.3 1.8 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Tetraspannin PF00335.15 KOO33719.1 - 1.7 7.8 10.3 0.082 12.1 2.8 1.9 2 1 0 2 2 2 0 Tetraspanin family adh_short PF00106.20 KOO33722.1 - 0.22 11.4 1.7 0.46 10.3 0.1 2.1 2 1 1 3 3 3 0 short chain dehydrogenase Aldedh PF00171.17 KOO33724.1 - 2.9e-154 513.8 0.3 3.3e-154 513.6 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 KOO33724.1 - 0.065 11.9 0.4 0.24 10.0 0.3 1.8 1 1 0 1 1 1 0 Acyl-CoA reductase (LuxC) BT1 PF03092.11 KOO33727.1 - 4.5e-60 203.5 10.0 6e-59 199.8 6.9 2.1 1 1 0 1 1 1 1 BT1 family DUF1810 PF08837.6 KOO33728.1 - 2.3e-16 59.6 0.0 3e-16 59.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1810) DUF1668 PF07893.8 KOO33728.1 - 0.044 12.9 0.1 0.059 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1668) DUF4600 PF15372.1 KOO33728.1 - 0.11 12.7 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4600) zf-DHHC PF01529.15 KOO33729.1 - 2.6e-40 137.6 2.1 6.6e-40 136.3 1.5 1.7 1 1 0 1 1 1 1 DHHC palmitoyltransferase Transglut_core3 PF13471.1 KOO33729.1 - 0.23 11.2 1.5 1.1 9.0 0.2 2.1 2 0 0 2 2 2 0 Transglutaminase-like superfamily Abhydrolase_5 PF12695.2 KOO33730.1 - 7.2e-11 42.0 0.1 2.7e-10 40.1 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO33730.1 - 1.1e-06 28.6 6.6 1.1e-06 28.6 4.6 2.8 2 1 2 4 4 4 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 KOO33730.1 - 0.00015 21.0 0.2 0.0016 17.7 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Esterase PF00756.15 KOO33730.1 - 0.00024 20.6 0.5 0.00054 19.4 0.4 1.7 1 1 0 1 1 1 1 Putative esterase Abhydrolase_1 PF00561.15 KOO33730.1 - 0.013 15.1 0.1 0.022 14.3 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Chlorophyllase2 PF12740.2 KOO33730.1 - 0.023 13.5 0.3 0.05 12.4 0.0 1.6 2 0 0 2 2 2 0 Chlorophyllase enzyme Abhydrolase_2 PF02230.11 KOO33730.1 - 0.045 13.1 0.0 0.51 9.7 0.0 2.1 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Chlorophyllase PF07224.6 KOO33730.1 - 0.051 12.3 0.1 0.09 11.5 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase HATPase_c PF02518.21 KOO33732.1 - 2.4e-05 24.0 0.0 4.3e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Lipase_3 PF01764.20 KOO33734.1 - 3e-24 85.2 0.0 5.8e-24 84.3 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.2 KOO33734.1 - 0.00038 20.3 2.0 0.00038 20.3 1.4 2.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family Thioesterase PF00975.15 KOO33734.1 - 0.00042 20.6 0.2 0.0012 19.1 0.1 1.8 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_5 PF12695.2 KOO33734.1 - 0.0012 18.6 0.2 0.0047 16.6 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family Esterase PF00756.15 KOO33734.1 - 0.02 14.2 0.1 0.04 13.3 0.0 1.4 1 0 0 1 1 1 0 Putative esterase DUF2974 PF11187.3 KOO33734.1 - 0.024 13.9 0.0 0.092 12.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) PGAP1 PF07819.8 KOO33734.1 - 0.064 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein DUF2048 PF09752.4 KOO33734.1 - 0.14 11.0 1.0 0.26 10.1 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2048) MTHFR PF02219.12 KOO33735.1 - 1.3e-06 27.7 0.0 1.9e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase RE_HaeIII PF09556.5 KOO33735.1 - 0.085 11.7 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 HaeIII restriction endonuclease Catalase-rel PF06628.7 KOO33736.1 - 0.00079 19.2 5.9 25 4.8 0.0 6.7 5 2 1 7 7 7 0 Catalase-related immune-responsive EF-hand_1 PF00036.27 KOO33736.1 - 0.0041 16.3 0.1 0.011 14.9 0.1 1.8 1 0 0 1 1 1 1 EF hand HMG_box PF00505.14 KOO33736.1 - 0.0051 17.0 40.9 0.29 11.4 0.9 8.1 4 4 5 9 9 9 3 HMG (high mobility group) box EF-hand_6 PF13405.1 KOO33736.1 - 0.012 15.4 0.1 0.032 14.0 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.1 KOO33736.1 - 0.021 14.9 0.1 0.069 13.2 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain pair MgtE_N PF03448.12 KOO33736.1 - 0.11 12.8 20.5 1.2 9.5 1.2 4.9 4 1 1 5 5 5 0 MgtE intracellular N domain DUF1104 PF06518.6 KOO33736.1 - 0.25 11.5 38.9 0.3 11.2 1.4 6.2 4 2 2 6 6 6 0 Protein of unknown function (DUF1104) DUF3106 PF11304.3 KOO33736.1 - 0.52 10.7 29.2 0.38 11.1 2.3 5.2 5 1 1 6 6 4 0 Protein of unknown function (DUF3106) DUF4473 PF14747.1 KOO33736.1 - 2.3 8.5 32.0 1.7 8.9 1.1 6.0 4 1 2 6 6 6 0 Domain of unknown function (DUF4473) HMG_box_2 PF09011.5 KOO33736.1 - 3.1 8.2 39.4 8.9 6.7 0.5 6.9 4 4 1 5 5 5 0 HMG-box domain Metal_resist PF13801.1 KOO33736.1 - 5.6 6.9 41.4 1.5 8.8 0.5 5.4 3 1 1 4 4 4 0 Heavy-metal resistance Sdh5 PF03937.11 KOO33736.1 - 6.4 6.5 9.5 3.2 7.5 0.1 4.8 5 1 0 5 5 5 0 Flavinator of succinate dehydrogenase Ank_2 PF12796.2 KOO33737.1 - 3.4e-11 43.3 0.4 7.2e-11 42.2 0.3 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO33737.1 - 3.3e-08 33.4 0.3 4.7e-07 29.8 0.1 2.8 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO33737.1 - 4.2e-08 33.4 0.1 5.3e-05 23.6 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO33737.1 - 4.8e-06 26.1 0.0 2.9e-05 23.6 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeat RPAP1_C PF08620.5 KOO33737.1 - 5.2e-05 22.9 20.9 28 4.6 0.0 12.2 14 2 0 14 14 14 0 RPAP1-like, C-terminal Ank_3 PF13606.1 KOO33737.1 - 6.8e-05 22.7 0.0 0.0038 17.3 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat N_methyl_2 PF13544.1 KOO33737.1 - 0.0022 17.3 0.0 32 4.2 0.0 7.3 7 0 0 7 7 7 0 Type IV pilin N-term methylation site GFxxxE MbeB_N PF04837.7 KOO33737.1 - 0.14 12.2 4.5 0.13 12.3 1.4 2.3 1 1 1 2 2 2 0 MbeB-like, N-term conserved region Rab5-bind PF09311.6 KOO33737.1 - 0.29 11.0 11.6 0.57 10.0 8.0 1.4 1 0 0 1 1 1 0 Rabaptin-like protein GST_C_2 PF13410.1 KOO33737.1 - 0.58 10.0 5.0 9.7 6.1 0.0 3.9 4 0 0 4 4 3 0 Glutathione S-transferase, C-terminal domain DUF883 PF05957.8 KOO33737.1 - 1.9 8.9 11.0 2.7 8.4 5.0 2.8 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) MRP-S26 PF14943.1 KOO33737.1 - 2.3 7.7 7.3 3.7 7.0 5.1 1.2 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Jnk-SapK_ap_N PF09744.4 KOO33737.1 - 4.3 7.2 6.3 17 5.3 3.1 2.0 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Ribosomal_L13e PF01294.13 KOO33737.1 - 4.4 6.7 23.5 41 3.5 0.0 8.9 4 2 6 11 11 11 0 Ribosomal protein L13e WD40 PF00400.27 KOO33739.1 - 7.3e-48 158.8 19.9 1.5e-12 46.8 0.3 5.0 5 0 0 5 5 5 4 WD domain, G-beta repeat PD40 PF07676.7 KOO33739.1 - 3.3e-11 42.6 0.2 0.15 11.7 0.0 4.4 4 0 0 4 4 4 4 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOO33739.1 - 1.7e-09 37.6 0.3 0.00055 19.7 0.0 2.9 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.1 KOO33739.1 - 4.2e-05 23.2 0.1 0.0059 16.3 0.0 2.9 1 1 2 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Nbas_N PF15492.1 KOO33739.1 - 0.00016 20.8 0.7 1.6 7.7 0.0 3.5 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal DUF3312 PF11768.3 KOO33739.1 - 0.00046 18.5 0.0 0.44 8.7 0.0 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF3312) Gmad1 PF10647.4 KOO33739.1 - 0.00078 18.9 0.0 0.22 10.9 0.0 3.2 3 2 0 3 3 3 1 Lipoprotein LpqB beta-propeller domain DUF3892 PF13031.1 KOO33739.1 - 0.0093 16.3 1.2 1.9 8.9 0.0 3.3 1 1 4 5 5 5 1 Protein of unknown function (DUF3892) Dfp1_Him1_M PF08630.5 KOO33739.1 - 0.0097 15.6 1.8 15 5.3 0.0 3.4 3 1 0 3 3 3 0 Dfp1/Him1, central region IKI3 PF04762.7 KOO33739.1 - 0.016 13.0 0.5 0.19 9.4 0.1 2.0 1 1 1 2 2 2 0 IKI3 family Proteasome_A_N PF10584.4 KOO33739.1 - 0.016 14.5 7.3 8.4 5.8 0.1 4.2 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature rOmpB PF12334.3 KOO33739.1 - 0.021 14.2 2.4 12 5.1 0.0 3.7 1 1 3 4 4 4 0 Rickettsia outer membrane protein B SGL PF08450.7 KOO33739.1 - 0.04 13.2 0.4 0.39 10.0 0.2 2.2 1 1 0 1 1 1 0 SMP-30/Gluconolaconase/LRE-like region DUF3255 PF11631.3 KOO33739.1 - 0.095 12.3 0.1 12 5.5 0.0 3.2 1 1 1 4 4 4 0 Protein of unknown function (DUF3255) DUF4467 PF14729.1 KOO33739.1 - 0.16 12.3 0.0 2 8.8 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function with cystatin-like fold (DUF4467) Rdx PF10262.4 KOO33740.1 - 0.00032 20.6 0.0 0.00091 19.2 0.0 1.8 1 0 0 1 1 1 1 Rdx family PTCB-BRCT PF12738.2 KOO33742.1 - 1.9e-06 27.6 0.1 3.5e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.21 KOO33742.1 - 0.00023 21.2 0.0 0.00032 20.7 0.0 1.2 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PRA-CH PF01502.13 KOO33743.1 - 1.2e-23 82.4 0.3 2e-23 81.8 0.2 1.3 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.12 KOO33743.1 - 2.5e-11 43.6 0.1 5.2e-11 42.6 0.1 1.6 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase 2OG-FeII_Oxy_3 PF13640.1 KOO33743.1 - 3e-05 24.4 0.0 0.00014 22.3 0.0 2.2 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MazG PF03819.12 KOO33743.1 - 0.18 11.7 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain DNA_ligase_OB_2 PF14743.1 KOO33744.1 - 2.3e-22 78.4 0.1 3.3e-22 77.9 0.1 1.2 1 0 0 1 1 1 1 DNA ligase OB-like domain zf-CCHC PF00098.18 KOO33746.1 - 0.024 14.5 0.3 0.039 13.8 0.2 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-nanos PF05741.8 KOO33746.1 - 0.12 12.4 0.9 0.63 10.0 0.6 2.0 1 1 1 2 2 2 0 Nanos RNA binding domain Abhydrolase_3 PF07859.8 KOO33747.1 - 3.7e-10 39.7 0.0 5.5e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold PDZ PF00595.19 KOO33747.1 - 4.2e-08 33.2 0.0 6.5e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO33747.1 - 0.0012 18.7 0.0 0.0018 18.1 0.0 1.3 1 0 0 1 1 1 1 PDZ domain zf-CCHC PF00098.18 KOO33748.1 - 0.02 14.7 0.3 0.035 14.0 0.2 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-nanos PF05741.8 KOO33748.1 - 0.1 12.6 1.0 0.59 10.1 0.7 2.1 1 1 1 2 2 2 0 Nanos RNA binding domain Mem_trans PF03547.13 KOO33749.1 - 1.8e-10 39.7 7.6 2.1e-08 32.8 1.5 2.1 2 0 0 2 2 2 2 Membrane transport protein EF-hand_1 PF00036.27 KOO33750.1 - 3.4e-26 88.4 10.5 1e-05 24.4 0.0 6.2 5 1 1 6 6 6 6 EF hand EF-hand_7 PF13499.1 KOO33750.1 - 2.3e-25 88.5 10.1 1.5e-10 41.0 0.5 4.2 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO33750.1 - 4.6e-20 69.6 13.0 6.4e-05 22.5 0.0 6.2 5 1 1 6 6 6 4 EF-hand domain EF-hand_5 PF13202.1 KOO33750.1 - 1.2e-17 62.3 8.4 4.5e-06 25.7 0.0 5.6 5 0 0 5 5 5 5 EF hand EF-hand_8 PF13833.1 KOO33750.1 - 2.6e-11 42.9 9.5 0.00023 20.6 0.5 4.8 5 1 0 5 5 5 3 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO33750.1 - 0.0031 17.5 2.5 0.06 13.3 0.0 3.0 3 1 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOO33750.1 - 0.0091 15.8 0.1 0.87 9.5 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain Armet PF10208.4 KOO33750.1 - 0.03 13.9 0.1 0.096 12.3 0.1 1.8 1 1 0 1 1 1 0 Degradation arginine-rich protein for mis-folding EF-hand_4 PF12763.2 KOO33750.1 - 0.12 12.1 1.5 0.69 9.6 0.2 2.7 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand VCBS PF13517.1 KOO33750.1 - 3.1 8.2 5.5 8.7 6.7 0.2 3.1 4 0 0 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF2181 PF10223.4 KOO33751.1 - 1.4e-35 122.8 0.0 1.8e-35 122.4 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2181) EF-hand_1 PF00036.27 KOO33752.1 - 9.5e-54 174.6 18.0 1.9e-05 23.6 0.0 12.6 11 2 2 13 13 13 11 EF hand EF-hand_7 PF13499.1 KOO33752.1 - 1.2e-51 172.6 24.0 1.1e-10 41.5 0.7 7.4 5 2 1 6 6 6 5 EF-hand domain pair EF-hand_6 PF13405.1 KOO33752.1 - 2.3e-42 139.0 27.0 7.4e-05 22.3 0.0 12.4 11 2 2 13 13 12 9 EF-hand domain EF-hand_5 PF13202.1 KOO33752.1 - 1e-38 128.9 17.5 1.4e-05 24.2 0.0 11.8 12 0 0 12 12 12 8 EF hand EF-hand_8 PF13833.1 KOO33752.1 - 1.7e-22 78.7 18.6 0.00012 21.6 0.1 9.8 10 1 0 10 10 10 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO33752.1 - 3.9e-08 33.3 5.2 0.63 10.0 0.0 5.4 5 1 2 7 7 7 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOO33752.1 - 6.9e-05 22.6 2.1 2.3 8.1 0.0 5.4 6 0 0 6 6 6 1 EF-hand domain DUF3872 PF12988.2 KOO33752.1 - 0.0027 17.2 4.2 2.5 7.6 0.1 4.8 4 1 1 5 5 5 1 Domain of unknown function, B. Theta Gene description (DUF3872) EAL PF00563.15 KOO33752.1 - 0.025 14.0 0.2 5 6.5 0.0 3.6 2 1 2 4 4 4 0 EAL domain Armet PF10208.4 KOO33752.1 - 0.046 13.3 0.0 0.19 11.3 0.0 2.1 2 0 0 2 2 2 0 Degradation arginine-rich protein for mis-folding EF-hand_2 PF09068.6 KOO33752.1 - 0.2 11.7 0.9 31 4.6 0.2 3.9 2 1 0 2 2 2 0 EF hand Phage_NinH PF06322.6 KOO33752.1 - 0.29 10.7 2.7 9.4 5.9 0.0 3.6 4 0 0 4 4 4 0 Phage NinH protein Glyco_hydro_28 PF00295.12 KOO33753.1 - 1.5e-32 112.8 0.5 2.9e-16 59.3 0.1 3.3 3 1 0 3 3 3 3 Glycosyl hydrolases family 28 Beta_helix PF13229.1 KOO33753.1 - 0.0085 15.8 0.2 4.4 7.0 0.0 3.4 2 2 0 2 2 2 2 Right handed beta helix region Filamin PF00630.14 KOO33754.1 - 2.4e-09 37.6 0.1 2.1e-07 31.4 0.1 2.5 2 0 0 2 2 2 1 Filamin/ABP280 repeat Big_1 PF02369.11 KOO33754.1 - 0.022 14.6 0.0 0.053 13.4 0.0 1.6 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) CarboxypepD_reg PF13620.1 KOO33754.1 - 0.046 13.7 0.1 0.14 12.2 0.0 1.8 2 0 0 2 2 2 0 Carboxypeptidase regulatory-like domain Neurexophilin PF06312.7 KOO33754.1 - 0.14 11.3 0.0 0.29 10.3 0.0 1.4 1 0 0 1 1 1 0 Neurexophilin Coprogen_oxidas PF01218.13 KOO33755.1 - 6.1e-80 267.9 0.0 7.4e-80 267.6 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase PDEase_I PF00233.14 KOO33756.1 - 1.5e-73 247.4 6.5 1.9e-50 171.8 0.1 3.0 2 1 1 3 3 3 3 3'5'-cyclic nucleotide phosphodiesterase DUF1011 PF06237.7 KOO33756.1 - 0.03 14.2 0.8 7.2 6.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1011) FAM195 PF14799.1 KOO33756.1 - 0.046 13.5 0.7 11 5.8 0.1 2.3 2 0 0 2 2 2 0 FAM195 family DUF3382 PF11862.3 KOO33756.1 - 1.3 8.9 6.5 10 6.0 0.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3382) Methyltransf_32 PF13679.1 KOO33757.1 - 6.5e-11 42.0 0.1 1.3e-10 41.1 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO33757.1 - 0.00043 19.9 0.0 0.00094 18.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO33757.1 - 0.00092 19.7 0.1 0.0024 18.4 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO33757.1 - 0.0071 16.3 1.9 0.021 14.8 1.4 1.7 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 KOO33757.1 - 0.0082 15.5 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW MTS PF05175.9 KOO33757.1 - 0.11 11.8 0.0 0.24 10.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain DOT1 PF08123.8 KOO33757.1 - 0.14 11.4 0.0 0.29 10.4 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 UPF0181 PF03701.9 KOO33759.1 - 1.8 7.8 9.2 0.095 12.0 0.9 2.6 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0181) LRR_6 PF13516.1 KOO33761.1 - 3.9e-14 51.0 30.4 0.3 11.2 0.1 13.1 14 0 0 14 14 14 5 Leucine Rich repeat LRR_1 PF00560.28 KOO33761.1 - 8.9e-14 49.4 13.2 4.1 7.8 0.0 9.9 9 1 0 9 9 9 5 Leucine Rich Repeat FIBP PF05427.6 KOO33761.1 - 5.8e-07 29.0 0.4 0.26 10.4 0.0 3.9 4 0 0 4 4 4 3 Acidic fibroblast growth factor binding (FIBP) LRR_4 PF12799.2 KOO33761.1 - 8.6e-07 28.4 18.2 3.9 7.2 0.1 8.5 7 2 1 8 8 8 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO33761.1 - 7.7e-06 25.5 10.3 58 3.5 0.0 8.7 8 1 0 8 8 8 0 Leucine rich repeat Skp1 PF01466.14 KOO33761.1 - 9.2e-05 22.3 0.0 0.00029 20.8 0.0 1.8 1 0 0 1 1 1 1 Skp1 family, dimerisation domain LRR_7 PF13504.1 KOO33761.1 - 0.00032 20.4 24.2 5 7.7 0.1 9.5 9 0 0 9 9 9 2 Leucine rich repeat Mg_chelatase_2 PF13335.1 KOO33761.1 - 0.0051 17.1 0.7 96 3.4 0.0 4.5 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI DUF902 PF06001.8 KOO33761.1 - 0.025 14.7 0.9 1.2e+02 2.9 0.0 4.5 4 0 0 4 4 4 0 Domain of Unknown Function (DUF902) Carbpep_Y_N PF05388.6 KOO33761.1 - 0.53 10.4 3.5 58 3.8 0.1 4.3 5 0 0 5 5 5 0 Carboxypeptidase Y pro-peptide Beach PF02138.13 KOO33762.1 - 8.8e-82 274.5 0.0 1.1e-81 274.2 0.0 1.1 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.1 KOO33762.1 - 1.1e-06 28.3 0.0 2.2e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.27 KOO33762.1 - 2.2e-06 27.3 1.9 1.2 9.1 0.0 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat Ank_2 PF12796.2 KOO33763.1 - 3.9e-16 59.1 8.2 1.1e-09 38.4 0.1 2.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO33763.1 - 2.3e-14 53.4 1.1 1.2e-08 35.2 0.1 4.3 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO33763.1 - 5.4e-14 51.1 4.9 2.8e-06 26.8 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ion_trans_2 PF07885.11 KOO33763.1 - 1.7e-13 50.0 8.0 1.7e-13 50.0 5.6 2.4 3 0 0 3 3 3 1 Ion channel Ank_5 PF13857.1 KOO33763.1 - 1.6e-12 47.2 2.8 4e-08 33.2 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO33763.1 - 1.4e-10 40.3 2.0 0.0019 18.2 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeat DUF1418 PF07214.7 KOO33763.1 - 0.013 15.1 0.2 0.045 13.3 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1418) Ion_trans PF00520.26 KOO33763.1 - 0.14 11.4 7.1 2.2 7.4 5.0 2.2 1 1 0 1 1 1 0 Ion transport protein DWNN PF08783.6 KOO33764.1 - 5.4e-21 74.3 0.0 7.4e-21 73.8 0.0 1.2 1 0 0 1 1 1 1 DWNN domain SAM_1 PF00536.25 KOO33767.1 - 0.027 14.6 0.5 0.15 12.2 0.3 2.0 1 1 0 1 1 1 0 SAM domain (Sterile alpha motif) Ribosomal_S5_C PF03719.10 KOO33768.1 - 4.6e-14 51.4 0.1 1.2e-13 50.1 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.15 KOO33768.1 - 9.4e-13 47.7 1.3 1.8e-12 46.8 0.9 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain PPR_2 PF13041.1 KOO33769.1 - 5.2e-47 157.5 0.0 2.1e-11 43.5 0.0 8.8 5 2 4 9 9 9 9 PPR repeat family PPR_1 PF12854.2 KOO33769.1 - 8.7e-43 143.4 10.0 2.6e-07 30.0 0.0 10.2 11 0 0 11 11 11 8 PPR repeat PPR_3 PF13812.1 KOO33769.1 - 3.3e-39 129.8 2.7 3.7e-05 23.6 0.0 9.3 9 0 0 9 9 9 8 Pentatricopeptide repeat domain PPR PF01535.15 KOO33769.1 - 4.3e-38 126.6 1.5 2.5e-05 23.9 0.0 11.0 12 0 0 12 12 12 8 PPR repeat TPR_19 PF14559.1 KOO33769.1 - 1.6e-05 25.1 3.6 1.7 9.0 0.0 4.7 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO33769.1 - 0.00039 20.7 19.8 3.9 8.3 0.5 8.3 5 2 4 9 9 9 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO33769.1 - 0.017 15.7 13.9 4.9 7.9 0.2 5.2 4 1 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO33769.1 - 0.051 13.4 0.2 30 4.8 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Meckelin PF09773.4 KOO33771.1 - 5.7e-142 474.3 2.0 3.9e-97 326.0 0.0 3.0 2 1 1 3 3 3 3 Meckelin (Transmembrane protein 67) S-AdoMet_synt_C PF02773.11 KOO33771.1 - 0.033 13.9 0.1 0.06 13.0 0.1 1.4 1 0 0 1 1 1 0 S-adenosylmethionine synthetase, C-terminal domain HC2 PF07382.6 KOO33774.1 - 0.00012 21.9 32.8 0.00016 21.5 22.7 1.2 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 PDZ_2 PF13180.1 KOO33775.1 - 2e-05 24.3 0.0 0.0079 16.0 0.0 3.3 3 0 0 3 3 3 1 PDZ domain PDZ PF00595.19 KOO33775.1 - 8.9e-05 22.5 0.0 0.00041 20.4 0.0 2.1 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) UBA PF00627.26 KOO33776.1 - 6.4e-11 41.7 0.5 2e-10 40.1 0.4 1.9 1 0 0 1 1 1 1 UBA/TS-N domain Kinesin-relat_1 PF12711.2 KOO33776.1 - 0.0026 18.0 7.0 0.25 11.7 0.8 2.6 1 1 1 2 2 2 2 Kinesin motor Nol1_Nop2_Fmu PF01189.12 KOO33776.1 - 0.016 14.5 0.1 0.85 8.9 0.0 2.5 3 0 0 3 3 3 0 NOL1/NOP2/sun family Spc24 PF08286.6 KOO33776.1 - 1.7 8.3 5.4 1.4 8.5 0.0 2.7 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 IncA PF04156.9 KOO33776.1 - 2.1 7.9 6.8 0.74 9.3 0.0 2.3 2 1 0 2 2 2 0 IncA protein PP2C PF00481.16 KOO33779.1 - 9e-31 107.1 0.0 1.1e-30 106.8 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOO33779.1 - 0.016 14.9 0.2 0.66 9.6 0.1 2.2 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) DEAD PF00270.24 KOO33780.1 - 1.5e-13 50.5 0.0 1e-12 47.9 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO33780.1 - 2.7e-05 23.9 0.0 0.00057 19.6 0.0 2.9 2 1 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.1 KOO33780.1 - 0.064 12.3 0.0 0.064 12.3 0.0 2.2 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit DHQS PF01959.11 KOO33781.1 - 2e-65 220.8 0.4 2e-59 201.1 0.1 2.0 1 1 1 2 2 2 2 3-dehydroquinate synthase (EC 4.6.1.3) Hint PF01079.15 KOO33781.1 - 0.0094 15.1 0.0 0.057 12.6 0.0 2.2 3 0 0 3 3 3 1 Hint module LRR_8 PF13855.1 KOO33782.1 - 2.9e-07 30.1 0.6 2.9e-07 30.1 0.4 1.8 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.2 KOO33782.1 - 0.0005 19.6 2.8 0.0032 17.0 0.6 2.6 1 1 1 2 2 2 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO33782.1 - 0.0014 18.4 0.5 0.41 10.8 0.1 3.5 4 0 0 4 4 4 1 Leucine Rich repeat DUF2976 PF11190.3 KOO33782.1 - 0.024 14.1 0.0 0.024 14.1 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2976) LRR_1 PF00560.28 KOO33782.1 - 0.065 13.2 0.2 0.39 10.9 0.0 2.4 2 0 0 2 2 2 0 Leucine Rich Repeat SKG6 PF08693.5 KOO33782.1 - 0.14 11.4 4.0 0.46 9.8 2.8 1.9 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF4083 PF13314.1 KOO33782.1 - 3 7.7 4.2 2 8.3 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) Cellulase PF00150.13 KOO33783.1 - 6.2e-09 35.4 0.1 0.0027 16.9 0.2 2.1 1 1 1 2 2 2 2 Cellulase (glycosyl hydrolase family 5) tRNA-synt_2b PF00587.20 KOO33784.1 - 1.9e-33 115.5 0.0 3.2e-33 114.7 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 KOO33784.1 - 1.3e-24 86.2 1.8 1.3e-24 86.2 1.3 2.9 3 0 0 3 3 3 1 Seryl-tRNA synthetase N-terminal domain Dpy-30 PF05186.8 KOO33784.1 - 1.3e-06 27.7 0.1 2.6e-06 26.8 0.1 1.4 1 0 0 1 1 1 1 Dpy-30 motif PEARLI-4 PF05278.7 KOO33784.1 - 1.3 8.3 10.6 0.39 10.0 0.7 2.4 2 0 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) Nucleotid_trans PF03407.11 KOO33787.1 - 4.9e-39 134.3 0.1 6.7e-39 133.8 0.1 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase O-FucT PF10250.4 KOO33787.1 - 0.18 10.8 0.1 0.28 10.2 0.0 1.2 1 0 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase EF-hand_1 PF00036.27 KOO33788.1 - 4.3e-19 66.3 4.4 5.9e-06 25.2 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO33788.1 - 2.7e-16 57.9 5.9 8.2e-06 25.2 0.1 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.1 KOO33788.1 - 2.8e-15 56.1 1.8 1e-08 35.2 0.1 3.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO33788.1 - 5.6e-12 45.0 1.7 0.0041 16.7 0.0 4.3 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO33788.1 - 1e-09 37.2 8.4 0.0014 17.9 0.1 4.4 4 0 0 4 4 4 3 EF hand FUSC PF04632.7 KOO33788.1 - 4.7 5.5 9.7 6.1 5.1 6.8 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family PUA PF01472.15 KOO33789.1 - 8.8e-16 57.4 0.0 1.1e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 PUA domain ArsD PF06953.6 KOO33790.1 - 0.029 14.5 0.0 0.7 10.0 0.0 2.4 3 0 0 3 3 3 0 Arsenical resistance operon trans-acting repressor ArsD Methyltransf_21 PF05050.7 KOO33791.1 - 7.5e-08 32.4 0.0 1.2e-07 31.7 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase FkbM domain DUF2149 PF09919.4 KOO33792.1 - 0.75 9.9 5.9 3 8.0 1.2 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2149) DUF1673 PF07895.6 KOO33792.1 - 5 6.6 10.2 5.4 6.4 6.5 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1673) cNMP_binding PF00027.24 KOO33793.1 - 1.1e-19 70.0 0.3 5.4e-09 35.7 0.2 4.6 3 2 0 3 3 3 3 Cyclic nucleotide-binding domain Ion_trans PF00520.26 KOO33793.1 - 2.8e-05 23.4 2.1 2.8e-05 23.4 1.4 2.6 2 0 0 2 2 2 1 Ion transport protein Ion_trans_2 PF07885.11 KOO33793.1 - 0.00013 21.6 2.2 0.00013 21.6 1.5 2.8 2 0 0 2 2 2 1 Ion channel Serglycin PF04360.7 KOO33795.1 - 0.0048 16.6 1.0 0.0057 16.3 0.7 1.2 1 0 0 1 1 1 1 Serglycin DUF1168 PF06658.7 KOO33795.1 - 4.4 6.8 7.4 19 4.7 5.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1168) Peptidase_M50 PF02163.17 KOO33796.1 - 1.4e-29 102.4 0.0 2.2e-29 101.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M50 PDZ PF00595.19 KOO33796.1 - 4.3e-06 26.8 0.0 1.3e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO33796.1 - 0.00047 19.9 0.0 0.0011 18.7 0.0 1.6 1 0 0 1 1 1 1 PDZ domain FAD_binding_8 PF08022.7 KOO33796.1 - 0.17 11.7 0.2 0.3 10.9 0.1 1.3 1 0 0 1 1 1 0 FAD-binding domain Neur_chan_LBD PF02931.18 KOO33797.1 - 1.4 8.0 4.6 0.28 10.3 0.1 2.1 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel ligand binding domain TMEM171 PF15471.1 KOO33797.1 - 2 7.1 4.6 1.4 7.5 0.4 2.1 1 1 0 2 2 2 0 Transmembrane protein family 171 Agenet PF05641.7 KOO33798.1 - 2.9e-06 27.3 1.1 0.16 12.1 0.0 4.1 4 0 0 4 4 4 2 Agenet domain Arm PF00514.18 KOO33799.1 - 1.8e-32 110.0 24.5 5.9e-05 22.7 0.0 8.0 8 0 0 8 8 8 7 Armadillo/beta-catenin-like repeat DsrH PF04077.7 KOO33799.1 - 0.0036 16.9 4.3 4.7 6.9 0.1 4.2 1 1 2 3 3 3 3 DsrH like protein EF-hand_6 PF13405.1 KOO33799.1 - 0.19 11.6 0.0 8.1 6.6 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain DSPc PF00782.15 KOO33800.1 - 7.3e-17 61.2 0.0 1.3e-16 60.4 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain VWA_2 PF13519.1 KOO33800.1 - 2.8e-05 24.2 0.1 0.00055 20.0 0.0 2.5 2 1 1 3 3 3 1 von Willebrand factor type A domain VWA_3 PF13768.1 KOO33800.1 - 0.012 15.3 0.0 0.044 13.4 0.0 2.1 1 1 0 1 1 1 0 von Willebrand factor type A domain PDZ PF00595.19 KOO33801.1 - 4.8e-06 26.6 0.1 8.3e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO33801.1 - 3.2e-05 23.7 0.0 6.8e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Ammonium_transp PF00909.16 KOO33802.1 - 4.7e-58 196.5 8.3 5.5e-58 196.3 5.7 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family Ank_2 PF12796.2 KOO33803.1 - 4e-92 302.7 53.8 3.3e-19 69.0 0.9 6.5 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank PF00023.25 KOO33803.1 - 8.2e-57 186.3 56.1 2.3e-07 30.2 0.2 12.1 12 0 0 12 12 12 11 Ankyrin repeat Ank_4 PF13637.1 KOO33803.1 - 5e-51 170.2 17.4 6e-10 39.3 0.1 8.4 5 2 3 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO33803.1 - 9.9e-51 168.6 40.4 3.1e-10 39.9 0.7 10.5 1 1 10 11 11 11 11 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO33803.1 - 2.6e-26 89.0 33.6 5.1e-05 23.1 0.1 12.4 12 0 0 12 12 12 8 Ankyrin repeat DUF4182 PF13790.1 KOO33803.1 - 0.0016 18.1 6.0 5.8 6.7 0.0 6.2 8 0 0 8 8 8 1 Domain of unknown function (DUF4182) FAD_binding_3 PF01494.14 KOO33804.1 - 1.1e-12 47.7 1.4 1.6e-12 47.2 1.0 1.1 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 KOO33804.1 - 0.00047 20.1 1.9 0.0011 18.9 1.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 KOO33804.1 - 0.00084 19.1 1.3 0.2 11.3 0.6 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_3 PF13738.1 KOO33804.1 - 0.0069 16.4 0.9 0.01 15.9 0.6 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 KOO33804.1 - 0.016 15.0 0.2 0.021 14.6 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 KOO33804.1 - 0.027 13.5 0.0 0.044 12.8 0.0 1.2 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase DAO PF01266.19 KOO33804.1 - 0.052 12.4 3.9 0.082 11.7 2.1 1.8 1 1 1 2 2 2 0 FAD dependent oxidoreductase NAD_Gly3P_dh_N PF01210.18 KOO33804.1 - 0.064 12.9 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pyr_redox PF00070.22 KOO33804.1 - 0.14 12.5 1.8 0.66 10.4 1.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 KOO33804.1 - 0.15 10.9 1.2 7.6 5.3 0.0 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein Complex1_LYR PF05347.10 KOO33807.1 - 1.8e-08 34.0 0.0 2.6e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 KOO33807.1 - 4.3e-08 33.2 0.0 6.2e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Complex1_LYR-like WD40 PF00400.27 KOO33810.1 - 4.7e-45 149.9 1.7 1.9e-11 43.3 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat PQQ_3 PF13570.1 KOO33810.1 - 0.00056 20.0 0.7 2.1 8.7 0.0 3.6 4 0 0 4 4 4 2 PQQ-like domain Nup160 PF11715.3 KOO33810.1 - 0.0029 15.7 0.2 0.35 8.9 0.0 2.9 1 1 2 3 3 3 2 Nucleoporin Nup120/160 SBP_bac_3 PF00497.15 KOO33810.1 - 0.12 11.5 0.1 0.32 10.2 0.0 1.6 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 Myb_DNA-binding PF00249.26 KOO33812.1 - 2e-33 114.1 2.4 4.2e-16 58.7 0.1 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO33812.1 - 2.9e-22 78.5 1.6 7.9e-14 51.5 0.0 2.6 1 1 1 2 2 2 2 Myb-like DNA-binding domain DUF2475 PF10629.4 KOO33814.1 - 4.3e-06 26.8 10.1 0.094 12.9 0.1 4.3 3 0 0 3 3 3 3 Protein of unknown function (DUF2475) DUF563 PF04577.9 KOO33815.1 - 4.2e-12 46.4 0.0 7.1e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF563) ETF PF01012.16 KOO33817.1 - 4.5e-42 143.5 1.7 6.3e-42 143.0 1.2 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ADH_zinc_N PF00107.21 KOO33817.1 - 0.0065 16.0 0.1 0.014 14.9 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase EIIBC-GUT_C PF07663.6 KOO33817.1 - 0.11 12.6 0.1 2.7 8.1 0.0 2.3 1 1 1 2 2 2 0 Sorbitol phosphotransferase enzyme II C-terminus WD40 PF00400.27 KOO33818.1 - 0.044 13.6 0.5 0.3 11.0 0.0 2.7 3 0 0 3 3 3 0 WD domain, G-beta repeat Epimerase PF01370.16 KOO33819.1 - 3.5e-49 167.3 0.0 6.7e-49 166.4 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Calpain_III PF01067.17 KOO33819.1 - 4.5e-25 88.0 0.0 3.8e-07 29.8 0.0 5.5 4 2 0 4 4 4 4 Calpain large subunit, domain III 3Beta_HSD PF01073.14 KOO33819.1 - 1.5e-12 46.8 0.0 2.6e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 KOO33819.1 - 6.9e-09 35.0 0.0 1.2e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.20 KOO33819.1 - 1.3e-05 25.2 0.0 1.3e-05 25.2 0.0 2.6 3 0 0 3 3 2 1 short chain dehydrogenase EF-hand_1 PF00036.27 KOO33819.1 - 0.00017 20.6 0.0 1 8.8 0.0 2.8 2 0 0 2 2 2 2 EF hand NAD_binding_4 PF07993.7 KOO33819.1 - 0.0024 16.8 0.0 0.0074 15.2 0.0 1.8 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.8 KOO33819.1 - 0.0045 16.2 0.0 0.011 14.9 0.0 1.7 1 0 0 1 1 1 1 NmrA-like family Epimerase_Csub PF13950.1 KOO33819.1 - 0.0087 15.9 0.0 0.037 13.9 0.0 2.1 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit 2OG-FeII_Oxy PF03171.15 KOO33819.1 - 0.048 13.9 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily EF-hand_7 PF13499.1 KOO33819.1 - 0.16 12.1 0.2 9.9 6.3 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_8 PF13833.1 KOO33820.1 - 1.9e-07 30.6 0.0 3.2e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO33820.1 - 3e-06 26.1 0.0 5.8e-06 25.2 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.1 KOO33820.1 - 0.00091 18.4 0.0 0.0016 17.7 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO33820.1 - 0.004 16.9 0.0 0.01 15.6 0.0 1.7 1 1 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 KOO33820.1 - 0.0043 17.1 0.0 0.0079 16.3 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair DUF1126 PF06565.7 KOO33821.1 - 0.11 11.9 0.1 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 Repeat of unknown function (DUF1126) Dak1_2 PF13684.1 KOO33821.1 - 2.6 6.8 7.0 3.9 6.3 4.8 1.2 1 0 0 1 1 1 0 Dihydroxyacetone kinase family UNC-93 PF05978.11 KOO33822.1 - 6.7e-12 45.1 4.3 6.7e-12 45.1 3.0 1.9 1 1 1 2 2 2 1 Ion channel regulatory protein UNC-93 DUF4246 PF14033.1 KOO33823.1 - 0.0096 14.5 0.0 0.01 14.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) Pkinase PF00069.20 KOO33824.1 - 1e-54 185.4 0.0 2.1e-54 184.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.24 KOO33824.1 - 5.3e-34 115.9 0.1 4.3e-16 58.4 0.0 2.7 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.12 KOO33824.1 - 3.6e-26 91.8 0.0 5.7e-26 91.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO33824.1 - 0.0008 18.4 0.0 0.0013 17.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO33824.1 - 0.038 13.7 1.5 0.52 9.9 0.0 3.2 4 0 0 4 4 4 0 Phosphotransferase enzyme family GRAM PF02893.15 KOO33824.1 - 0.051 13.0 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 GRAM domain RGS PF00615.14 KOO33824.1 - 0.071 13.2 0.0 0.19 11.8 0.0 1.7 1 0 0 1 1 1 0 Regulator of G protein signaling domain LBR_tudor PF09465.5 KOO33825.1 - 9.8e-10 37.9 0.0 0.0057 16.2 0.0 3.4 3 0 0 3 3 3 3 Lamin-B receptor of TUDOR domain 53-BP1_Tudor PF09038.5 KOO33825.1 - 0.0007 19.4 0.0 0.19 11.5 0.0 3.1 3 0 0 3 3 3 1 Tumour suppressor p53-binding protein-1 Tudor SMN PF06003.7 KOO33825.1 - 0.0015 17.7 0.0 0.19 10.8 0.0 2.9 1 1 2 3 3 3 1 Survival motor neuron protein (SMN) EF-hand_7 PF13499.1 KOO33825.1 - 0.0025 17.8 0.2 0.005 16.9 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair Agenet PF05641.7 KOO33825.1 - 0.004 17.2 0.0 5.9 7.1 0.0 3.3 3 0 0 3 3 3 1 Agenet domain Rad9_Rad53_bind PF08605.5 KOO33825.1 - 0.012 15.3 0.0 1.3 8.7 0.0 3.0 2 1 1 3 3 3 0 Fungal Rad9-like Rad53-binding EF-hand_6 PF13405.1 KOO33825.1 - 0.033 14.0 0.0 0.18 11.7 0.0 2.3 1 0 0 1 1 1 0 EF-hand domain EF-hand_1 PF00036.27 KOO33825.1 - 0.034 13.4 0.2 0.24 10.7 0.0 2.4 3 0 0 3 3 3 0 EF hand ABC_membrane PF00664.18 KOO33826.1 - 4.9e-23 81.9 1.0 5.9e-23 81.6 0.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region Pkinase PF00069.20 KOO33827.1 - 9.4e-71 238.0 0.0 1.3e-70 237.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33827.1 - 7e-49 166.2 0.0 1.1e-48 165.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO33827.1 - 6.9e-05 21.9 0.0 0.00023 20.2 0.0 1.7 2 0 0 2 2 2 1 Kinase-like PH PF00169.24 KOO33827.1 - 0.00054 20.1 0.0 0.0011 19.1 0.0 1.4 1 0 0 1 1 1 1 PH domain APH PF01636.18 KOO33827.1 - 0.013 15.2 1.2 0.17 11.5 0.0 2.7 2 1 0 3 3 3 0 Phosphotransferase enzyme family RIO1 PF01163.17 KOO33827.1 - 0.025 13.9 0.0 0.044 13.1 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.9 KOO33827.1 - 0.034 13.2 0.1 0.08 11.9 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family E1-E2_ATPase PF00122.15 KOO33828.1 - 2.6e-63 213.1 0.0 4.2e-63 212.4 0.0 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 KOO33828.1 - 4.6e-39 133.8 0.0 1e-38 132.6 0.0 1.6 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 KOO33828.1 - 5.1e-31 108.7 0.0 3e-30 106.2 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOO33828.1 - 3.7e-20 71.6 0.0 6.3e-20 70.9 0.0 1.4 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 KOO33828.1 - 2.6e-13 50.5 0.0 5.1e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 KOO33828.1 - 1.3e-12 47.0 0.0 2.7e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 KOO33828.1 - 1.9e-05 24.3 0.6 1.9e-05 24.3 0.4 1.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3431 PF11913.3 KOO33830.1 - 9.8e-17 61.1 0.0 2e-16 60.1 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3431) LRR_6 PF13516.1 KOO33831.1 - 2.1e-09 36.4 0.0 0.0061 16.5 0.0 5.0 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.2 KOO33831.1 - 0.018 14.6 0.0 0.22 11.2 0.0 2.2 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) FKBP_C PF00254.23 KOO33832.1 - 5e-23 80.9 0.0 1.3e-22 79.6 0.0 1.7 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase CS PF04969.11 KOO33832.1 - 7.4e-09 36.0 0.0 1.1e-08 35.4 0.0 1.3 1 0 0 1 1 1 1 CS domain DnaJ PF00226.26 KOO33832.1 - 0.00012 21.7 0.1 0.00019 21.0 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain EamA PF00892.15 KOO33833.1 - 0.012 15.6 7.7 0.056 13.4 0.1 3.2 2 1 0 3 3 3 0 EamA-like transporter family YrhK PF14145.1 KOO33833.1 - 0.48 10.1 2.5 9.6 5.9 0.0 2.8 3 0 0 3 3 3 0 YrhK-like protein Cys_Met_Meta_PP PF01053.15 KOO33834.1 - 6.2e-127 423.0 0.1 7.1e-127 422.8 0.1 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 KOO33834.1 - 5.4e-09 35.5 0.2 8.4e-09 34.9 0.2 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.16 KOO33834.1 - 4.7e-08 32.3 0.2 7.2e-08 31.7 0.2 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 KOO33834.1 - 2.7e-06 26.3 0.3 4.6e-06 25.6 0.2 1.3 1 0 0 1 1 1 1 Aminotransferase class-V GDC-P PF02347.11 KOO33834.1 - 3.8e-05 22.5 0.5 6.1e-05 21.9 0.4 1.4 1 0 0 1 1 1 1 Glycine cleavage system P-protein SLA_LP_auto_ag PF05889.8 KOO33834.1 - 8.5e-05 21.1 0.0 0.00014 20.4 0.0 1.2 1 0 0 1 1 1 1 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) Beta_elim_lyase PF01212.16 KOO33834.1 - 0.0016 17.6 0.1 0.0042 16.2 0.1 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase Dehalogenase PF13486.1 KOO33834.1 - 0.021 14.2 0.3 0.044 13.2 0.2 1.6 1 0 0 1 1 1 0 Reductive dehalogenase subunit Glyco_transf_41 PF13844.1 KOO33836.1 - 6.9e-25 86.9 0.0 9.1e-25 86.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 41 TPR_11 PF13414.1 KOO33836.1 - 4.8e-19 67.7 24.3 1.7e-06 27.5 1.7 4.5 3 1 3 6 6 6 4 TPR repeat TPR_2 PF07719.12 KOO33836.1 - 1e-14 53.1 17.5 0.0014 18.4 0.1 6.4 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.23 KOO33836.1 - 1.6e-12 46.4 1.5 0.094 12.3 0.1 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.1 KOO33836.1 - 8.3e-12 44.3 3.2 0.79 10.0 0.0 6.0 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.1 KOO33836.1 - 2.5e-09 36.2 0.0 0.3 10.9 0.0 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO33836.1 - 1.2e-07 32.2 24.6 9e-06 26.2 4.6 5.3 2 2 4 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOO33836.1 - 3.1e-07 30.2 24.8 0.0069 16.3 3.8 4.6 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.1 KOO33836.1 - 0.0015 18.9 40.1 0.035 14.7 3.2 7.4 1 1 7 8 8 8 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOO33836.1 - 0.0021 18.4 7.2 2.8 8.6 0.3 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO33836.1 - 0.015 15.1 21.4 0.016 15.0 2.3 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat EST1_DNA_bind PF10373.4 KOO33836.1 - 0.024 13.8 0.1 0.041 13.1 0.0 1.3 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain BTAD PF03704.12 KOO33836.1 - 0.31 11.3 19.1 0.033 14.4 7.8 3.2 1 1 1 2 2 2 0 Bacterial transcriptional activator domain DUF1637 PF07847.7 KOO33837.1 - 1.3e-45 155.2 0.0 1.6e-45 154.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1637) CDO_I PF05995.7 KOO33837.1 - 0.045 12.9 0.0 0.076 12.1 0.0 1.3 1 0 0 1 1 1 0 Cysteine dioxygenase type I Kinesin PF00225.18 KOO33838.1 - 4.4e-87 291.9 0.0 1.2e-86 290.4 0.0 1.7 1 0 0 1 1 1 1 Kinesin motor domain WD40_alt PF14077.1 KOO33838.1 - 0.74 9.4 15.7 13 5.5 0.1 5.2 5 0 0 5 5 5 0 Alternative WD40 repeat motif Reo_sigmaC PF04582.7 KOO33838.1 - 0.98 8.5 6.3 0.82 8.7 2.2 2.4 2 0 0 2 2 2 0 Reovirus sigma C capsid protein TPR_12 PF13424.1 KOO33841.1 - 7.2e-33 112.3 7.6 1.2e-16 60.3 0.1 3.4 1 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.1 KOO33841.1 - 8.2e-23 79.5 8.8 5.9e-09 35.5 0.1 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO33841.1 - 2.4e-12 45.6 6.6 0.0019 17.8 0.0 4.5 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO33841.1 - 1.8e-10 39.9 0.3 0.0087 15.6 0.0 3.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO33841.1 - 4.7e-10 38.5 1.1 0.041 13.7 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO33841.1 - 4.1e-09 36.8 9.2 6.1e-06 26.7 0.3 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO33841.1 - 1.5e-07 30.9 4.0 1.7e-05 24.3 0.2 2.6 2 2 0 2 2 2 2 TPR repeat TPR_17 PF13431.1 KOO33841.1 - 4.6e-07 29.5 0.1 1.4 9.3 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_4 PF07721.9 KOO33841.1 - 9.9e-07 28.6 12.0 0.21 12.1 0.0 5.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOO33841.1 - 1.3e-06 28.6 9.6 0.00034 20.8 0.4 3.4 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOO33841.1 - 3e-06 27.3 4.3 0.65 10.5 0.0 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO33841.1 - 3e-06 27.3 17.2 0.065 13.8 0.1 5.2 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO33841.1 - 0.0001 21.8 0.3 2 8.3 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_3 PF07720.7 KOO33841.1 - 0.00042 20.0 0.0 4.7 7.1 0.0 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat Apc3 PF12895.2 KOO33841.1 - 0.0094 16.0 0.1 0.072 13.2 0.0 2.3 1 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 Cation_ATPase_N PF00690.21 KOO33841.1 - 0.094 12.1 0.1 0.61 9.5 0.0 2.1 2 0 0 2 2 2 0 Cation transporter/ATPase, N-terminus DUF2452 PF10504.4 KOO33842.1 - 6e-14 51.6 6.0 2.2e-11 43.2 0.1 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2452) Pkinase PF00069.20 KOO33843.1 - 5.3e-28 97.8 0.0 2.4e-27 95.7 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain PARP PF00644.15 KOO33843.1 - 5.9e-16 58.5 0.0 1.5e-15 57.1 0.0 1.6 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Pkinase_Tyr PF07714.12 KOO33843.1 - 1.6e-15 56.8 0.0 2.5e-11 43.1 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.1 KOO33843.1 - 0.0011 18.0 0.0 0.0021 17.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOO33843.1 - 0.0044 16.1 0.0 0.011 14.8 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Spc7 PF08317.6 KOO33843.1 - 2.4 6.7 8.4 0.1 11.2 1.8 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein SNARE PF05739.14 KOO33844.1 - 1.2e-20 72.9 1.3 1.2e-20 72.9 0.9 2.3 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.20 KOO33844.1 - 1.6e-18 66.7 0.5 1.6e-18 66.7 0.3 2.3 2 0 0 2 2 2 1 Syntaxin Syntaxin_2 PF14523.1 KOO33844.1 - 0.00016 21.6 1.5 0.00016 21.6 1.0 2.4 2 1 0 2 2 2 1 Syntaxin-like protein Pox_P4A PF03395.9 KOO33844.1 - 0.015 12.9 0.5 0.02 12.4 0.0 1.4 2 0 0 2 2 2 0 Poxvirus P4A protein OppC_N PF12911.2 KOO33844.1 - 0.029 13.7 3.0 0.058 12.7 2.1 1.4 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C Baculo_PEP_C PF04513.7 KOO33844.1 - 0.084 12.6 0.2 3.3 7.5 0.0 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Herpes_US9 PF06072.6 KOO33844.1 - 0.14 12.0 1.5 0.3 10.9 1.0 1.5 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 Spectrin PF00435.16 KOO33844.1 - 0.19 12.0 2.6 15 5.9 0.0 3.1 3 0 0 3 3 3 0 Spectrin repeat WXG100 PF06013.7 KOO33844.1 - 0.39 10.7 4.2 7.6 6.6 0.1 3.6 2 1 0 3 3 3 0 Proteins of 100 residues with WXG DUF883 PF05957.8 KOO33844.1 - 2 8.8 10.2 2.3 8.6 0.9 3.5 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Synaptobrevin PF00957.16 KOO33844.1 - 2.7 7.6 8.8 0.8 9.3 1.9 2.7 3 1 0 3 3 3 0 Synaptobrevin TilS PF09179.6 KOO33847.1 - 0.049 13.6 0.1 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 TilS substrate binding domain FHA PF00498.21 KOO33849.1 - 1.2e-14 54.1 0.0 2e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 FHA domain DUF433 PF04255.9 KOO33849.1 - 0.028 13.8 0.1 0.96 8.9 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF433) DUF4192 PF13830.1 KOO33849.1 - 0.039 13.6 0.0 0.082 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) HC2 PF07382.6 KOO33850.1 - 4.9e-15 55.9 218.8 3.4e-07 30.3 34.0 4.4 2 1 3 5 5 5 4 Histone H1-like nucleoprotein HC2 Pentapeptide_4 PF13599.1 KOO33852.1 - 6.3e-08 32.3 38.3 1e-05 25.2 6.8 3.0 1 1 3 4 4 4 4 Pentapeptide repeats (9 copies) Pentapeptide PF00805.17 KOO33852.1 - 0.033 13.4 20.4 0.17 11.1 1.6 4.3 4 1 1 5 5 5 0 Pentapeptide repeats (8 copies) LRR_6 PF13516.1 KOO33853.1 - 4.4e-06 26.2 2.8 5.5 7.3 0.1 5.7 5 0 0 5 5 5 2 Leucine Rich repeat ADPrib_exo_Tox PF03496.9 KOO33853.1 - 8.5e-06 25.1 0.0 1.7e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme ART PF01129.13 KOO33853.1 - 0.0086 15.2 0.0 0.033 13.2 0.0 1.9 2 1 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase LRR_1 PF00560.28 KOO33853.1 - 0.025 14.5 0.4 5.8 7.3 0.0 4.2 4 0 0 4 4 4 0 Leucine Rich Repeat EF-hand_10 PF14788.1 KOO33854.1 - 0.027 14.1 0.2 0.37 10.4 0.1 2.3 2 0 0 2 2 2 0 EF hand EF-hand_1 PF00036.27 KOO33854.1 - 0.035 13.4 0.0 9.8 5.7 0.0 2.4 2 0 0 2 2 2 0 EF hand SPX PF03105.14 KOO33854.1 - 0.068 12.9 2.5 0.079 12.7 1.8 1.1 1 0 0 1 1 1 0 SPX domain EF-hand_6 PF13405.1 KOO33854.1 - 0.14 12.0 0.0 33 4.7 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain DUF966 PF06136.8 KOO33854.1 - 0.52 9.6 6.9 0.65 9.3 4.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) APG6 PF04111.7 KOO33854.1 - 0.72 8.8 11.4 1 8.3 7.9 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Parvo_coat PF00740.13 KOO33854.1 - 0.99 8.2 2.6 1.3 7.9 1.8 1.1 1 0 0 1 1 1 0 Parvovirus coat protein VP2 Adeno_E3_CR2 PF02439.10 KOO33855.1 - 1.5 8.4 4.7 2.3 7.8 3.3 1.2 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Rotamase PF00639.16 KOO33856.1 - 8.2e-21 74.5 0.1 1.9e-20 73.3 0.0 1.7 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 KOO33856.1 - 1.1e-13 51.4 0.0 2e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 KOO33856.1 - 0.04 14.5 0.0 0.093 13.3 0.0 1.6 1 0 0 1 1 1 0 PPIC-type PPIASE domain B9-C2 PF07162.6 KOO33861.1 - 3.6e-49 166.7 0.0 4.1e-49 166.5 0.0 1.0 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein DEAD PF00270.24 KOO33863.1 - 9.4e-18 64.2 0.0 2.6e-17 62.8 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO33863.1 - 1.2e-10 41.1 0.1 3.4e-09 36.4 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HRDC PF00570.18 KOO33863.1 - 0.0019 17.8 0.1 0.0043 16.7 0.1 1.7 1 0 0 1 1 1 1 HRDC domain ResIII PF04851.10 KOO33863.1 - 0.041 13.7 0.0 0.2 11.4 0.0 2.1 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Glyco_hydro_3 PF00933.16 KOO33864.1 - 1.4e-61 208.1 0.0 1.9e-61 207.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain DUF1538 PF07556.6 KOO33866.1 - 4e-81 271.1 44.4 4.9e-46 156.4 10.9 3.6 4 0 0 4 4 4 2 Protein of unknown function (DUF1538) SWIM PF04434.12 KOO33867.1 - 0.0012 18.2 0.4 0.0022 17.4 0.3 1.5 1 0 0 1 1 1 1 SWIM zinc finger Neur_chan_LBD PF02931.18 KOO33868.1 - 8.7e-05 21.7 0.0 0.00016 20.8 0.0 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain EF-hand_6 PF13405.1 KOO33868.1 - 0.019 14.8 0.1 0.047 13.5 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.1 KOO33868.1 - 0.026 14.6 0.0 0.058 13.5 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair DUF2681 PF10883.3 KOO33868.1 - 0.074 13.2 0.1 0.27 11.4 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) EF-hand_1 PF00036.27 KOO33868.1 - 0.1 11.9 0.3 0.23 10.8 0.2 1.6 1 0 0 1 1 1 0 EF hand SPX PF03105.14 KOO33870.1 - 1.7e-21 77.2 1.0 1.6e-10 41.2 0.0 2.7 2 1 1 3 3 3 2 SPX domain VTC PF09359.5 KOO33870.1 - 7.2e-19 67.8 0.0 1.1e-18 67.2 0.0 1.3 1 0 0 1 1 1 1 VTC domain UBA PF00627.26 KOO33871.1 - 5.2e-09 35.6 0.1 1.2e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain PX PF00787.19 KOO33871.1 - 5e-05 23.0 0.0 7.4e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 PX domain UIM PF02809.15 KOO33871.1 - 0.0056 16.1 1.2 0.0056 16.1 0.8 3.2 3 0 0 3 3 3 2 Ubiquitin interaction motif UBA_4 PF14555.1 KOO33871.1 - 0.035 13.6 0.0 0.089 12.3 0.0 1.7 1 0 0 1 1 1 0 UBA-like domain DNA_pol_A_exo1 PF01612.15 KOO33873.1 - 2.2e-20 72.8 0.0 2.8e-20 72.5 0.0 1.1 1 0 0 1 1 1 1 3'-5' exonuclease YhfH PF14149.1 KOO33876.1 - 0.012 15.4 0.3 0.039 13.7 0.2 1.9 1 0 0 1 1 1 0 YhfH-like protein ABC1 PF03109.11 KOO33877.1 - 1.5e-32 112.0 0.0 4.4e-24 84.7 0.0 2.8 1 1 1 2 2 2 2 ABC1 family APH PF01636.18 KOO33877.1 - 0.0015 18.3 3.7 0.092 12.4 0.0 4.3 3 2 1 5 5 5 1 Phosphotransferase enzyme family MGC-24 PF05283.6 KOO33877.1 - 0.015 15.0 1.4 0.029 14.1 1.0 1.4 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24) VCBS PF13517.1 KOO33881.1 - 7.6e-55 183.1 74.0 4.1e-13 49.4 2.6 7.5 3 2 4 7 7 7 6 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO33881.1 - 9.2e-41 136.6 63.5 1.4e-06 27.8 0.2 7.7 7 0 0 7 7 7 7 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO33881.1 - 6.2e-13 48.5 26.9 0.18 11.2 0.1 7.3 2 2 5 7 7 7 7 Insecticide toxin TcdB middle/N-terminal region Laminin_G_3 PF13385.1 KOO33881.1 - 1.2e-09 38.5 0.2 4.9e-09 36.6 0.1 2.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BBS2_Mid PF14783.1 KOO33881.1 - 0.13 12.0 3.6 99 2.7 0.0 5.5 7 0 0 7 7 7 0 Ciliary BBSome complex subunit 2, middle region CBM_6 PF03422.10 KOO33881.1 - 0.16 12.1 10.8 1.7 8.7 0.0 4.1 4 1 0 4 4 4 0 Carbohydrate binding module (family 6) PixA PF12306.3 KOO33881.1 - 0.76 9.6 3.5 16 5.2 0.0 3.9 4 1 1 5 5 5 0 Inclusion body protein EF-hand_1 PF00036.27 KOO33881.1 - 1.3 8.5 30.2 37 3.9 0.2 7.2 7 0 0 7 7 7 0 EF hand EF-hand_5 PF13202.1 KOO33881.1 - 5.2 6.5 45.5 10 5.6 0.4 7.3 7 0 0 7 7 7 0 EF hand AOX PF01786.12 KOO33882.1 - 8.3e-32 110.2 0.2 1e-31 109.9 0.1 1.1 1 0 0 1 1 1 1 Alternative oxidase GIDA PF01134.17 KOO33883.1 - 1.7e-133 445.3 0.0 2.8e-133 444.5 0.0 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc_3 PF13932.1 KOO33883.1 - 5.1e-18 64.9 0.0 1.4e-17 63.5 0.0 1.8 1 0 0 1 1 1 1 GidA associated domain 3 FAD_oxidored PF12831.2 KOO33883.1 - 3.1e-07 29.8 3.4 5.2e-07 29.0 2.3 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 KOO33883.1 - 5.6e-06 26.3 0.3 1.1e-05 25.4 0.2 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 KOO33883.1 - 2.8e-05 23.1 7.0 0.0001 21.3 2.6 2.3 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.19 KOO33883.1 - 0.00038 19.4 6.3 0.033 13.0 1.5 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.22 KOO33883.1 - 0.0028 18.0 1.9 0.0089 16.4 1.2 2.0 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 KOO33883.1 - 0.014 14.5 4.3 0.18 10.9 3.0 2.1 1 1 0 1 1 1 0 Thi4 family HI0933_like PF03486.9 KOO33883.1 - 0.023 13.1 3.3 0.087 11.2 2.3 1.8 2 0 0 2 2 2 0 HI0933-like protein AlaDh_PNT_C PF01262.16 KOO33883.1 - 0.036 13.6 0.9 0.084 12.4 0.7 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.14 KOO33883.1 - 0.047 12.7 2.4 0.092 11.7 1.7 1.4 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.1 KOO33883.1 - 0.089 12.8 1.5 0.22 11.5 0.6 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 KOO33883.1 - 0.23 11.5 2.9 0.52 10.3 1.5 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.9 KOO33883.1 - 0.64 8.5 1.9 0.95 8.0 1.3 1.2 1 0 0 1 1 1 0 Tryptophan halogenase MA3 PF02847.12 KOO33884.1 - 5.7e-19 67.8 0.0 1.2e-18 66.8 0.0 1.5 1 0 0 1 1 1 1 MA3 domain MIF4G PF02854.14 KOO33884.1 - 0.0004 19.8 0.1 0.0013 18.1 0.0 1.8 2 0 0 2 2 2 1 MIF4G domain Ank_2 PF12796.2 KOO33885.1 - 4.1e-15 55.9 0.1 7.8e-09 35.7 0.0 2.8 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO33885.1 - 5.5e-12 44.8 0.6 0.0035 17.0 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.1 KOO33885.1 - 1.8e-08 34.3 2.3 0.00018 21.6 0.2 3.2 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO33885.1 - 5.8e-08 33.0 0.1 0.018 15.5 0.1 3.7 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO33885.1 - 2e-05 24.3 0.4 2.1 8.8 0.0 4.4 6 0 0 6 6 6 2 Ankyrin repeat ShK PF01549.19 KOO33886.1 - 4.3e-42 142.1 101.1 2.5e-08 34.1 7.1 8.1 8 0 0 8 8 8 7 ShK domain-like DnaJ PF00226.26 KOO33886.1 - 7.8e-20 70.3 0.4 1.3e-19 69.7 0.3 1.4 1 0 0 1 1 1 1 DnaJ domain DUF2576 PF10845.3 KOO33886.1 - 5.9 6.1 8.0 9.8 5.4 0.8 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2576) p450 PF00067.17 KOO33888.1 - 3.7e-12 45.5 0.0 5.1e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 SelR PF01641.13 KOO33889.1 - 7e-12 45.1 0.0 1.5e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 SelR domain SAP PF02037.22 KOO33889.1 - 5.4e-08 32.1 0.1 1e-07 31.2 0.1 1.5 1 0 0 1 1 1 1 SAP domain WD40 PF00400.27 KOO33890.1 - 3.4e-60 197.9 26.5 2.8e-12 46.0 0.3 8.0 8 0 0 8 8 8 7 WD domain, G-beta repeat LisH PF08513.6 KOO33890.1 - 2.8e-09 36.4 0.2 5.3e-09 35.5 0.1 1.5 1 0 0 1 1 1 1 LisH eIF2A PF08662.6 KOO33890.1 - 2.8e-09 36.9 0.4 0.012 15.3 0.1 3.2 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.6 KOO33890.1 - 0.032 12.9 0.5 0.076 11.7 0.3 1.7 1 1 0 1 1 1 0 Nup133 N terminal like IKI3 PF04762.7 KOO33890.1 - 0.39 8.4 2.7 2.1 6.0 1.9 2.0 1 1 0 1 1 1 0 IKI3 family ubiquitin PF00240.18 KOO33891.1 - 7.9e-05 21.9 0.0 0.00015 21.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 KOO33891.1 - 0.011 15.4 0.0 0.021 14.4 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like CENP-B_dimeris PF09026.5 KOO33891.1 - 0.11 12.7 6.3 0.24 11.6 4.4 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Ribosomal_L11 PF00298.14 KOO33892.1 - 0.14 12.3 1.2 0.24 11.5 0.9 1.5 1 0 0 1 1 1 0 Ribosomal protein L11, RNA binding domain MtaB PF12176.3 KOO33892.1 - 0.15 10.4 3.5 0.15 10.4 2.4 1.0 1 0 0 1 1 1 0 Methanol-cobalamin methyltransferase B subunit LOH1CR12 PF10158.4 KOO33892.1 - 1.4 8.6 10.2 0.84 9.4 6.0 1.4 1 1 0 1 1 1 0 Tumour suppressor protein LUC7 PF03194.10 KOO33892.1 - 1.5 8.2 11.1 1.6 8.1 7.7 1.1 1 0 0 1 1 1 0 LUC7 N_terminus SPT16 PF08644.6 KOO33892.1 - 2.2 8.1 7.3 2.7 7.8 5.1 1.1 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) DASH_Dad2 PF08654.5 KOO33892.1 - 2.7 8.0 10.1 11 6.0 7.0 1.9 1 1 0 1 1 1 0 DASH complex subunit Dad2 HSP70 PF00012.15 KOO33892.1 - 3.3 5.5 9.2 3.6 5.3 6.4 1.0 1 0 0 1 1 1 0 Hsp70 protein Peptidase_M41 PF01434.13 KOO33893.1 - 9.4e-68 227.8 0.1 1.5e-67 227.1 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 KOO33893.1 - 1.2e-42 145.2 0.0 2.7e-42 144.0 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) FtsH_ext PF06480.10 KOO33893.1 - 1.7e-11 44.2 0.0 4.3e-11 42.9 0.0 1.7 1 0 0 1 1 1 1 FtsH Extracellular AAA_5 PF07728.9 KOO33893.1 - 5.1e-05 23.0 0.0 0.00022 20.9 0.0 2.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 KOO33893.1 - 0.00096 19.3 0.4 0.071 13.2 0.0 2.8 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 KOO33893.1 - 0.0012 18.2 0.1 0.028 13.8 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein RuvB_N PF05496.7 KOO33893.1 - 0.0014 17.7 0.0 0.004 16.2 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 KOO33893.1 - 0.0014 19.4 0.0 0.0073 17.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KOO33893.1 - 0.0047 16.6 0.6 0.024 14.3 0.4 2.2 1 0 0 1 1 1 1 Part of AAA domain TIP49 PF06068.8 KOO33893.1 - 0.0051 15.5 0.0 0.0093 14.7 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus AAA_2 PF07724.9 KOO33893.1 - 0.0058 16.5 0.0 0.026 14.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) Zeta_toxin PF06414.7 KOO33893.1 - 0.011 14.8 0.0 0.026 13.6 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.1 KOO33893.1 - 0.012 15.6 1.8 0.033 14.1 0.1 2.5 2 1 1 3 3 3 0 AAA ATPase domain AAA_25 PF13481.1 KOO33893.1 - 0.013 14.8 0.7 0.043 13.2 0.2 2.0 1 1 1 2 2 2 0 AAA domain Zn_peptidase_2 PF04298.7 KOO33893.1 - 0.024 13.9 0.7 0.18 11.1 0.1 2.1 2 0 0 2 2 2 0 Putative neutral zinc metallopeptidase Mg_chelatase PF01078.16 KOO33893.1 - 0.04 13.0 0.1 0.1 11.7 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.1 KOO33893.1 - 0.044 13.6 0.0 0.092 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 KOO33893.1 - 0.053 13.4 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 KOO33893.1 - 0.054 13.4 0.1 2.3 8.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain LRR_6 PF13516.1 KOO33894.1 - 7.2e-17 59.5 1.4 0.00039 20.1 0.0 4.6 4 0 0 4 4 4 3 Leucine Rich repeat BRCT PF00533.21 KOO33894.1 - 0.047 13.8 0.0 0.091 12.9 0.0 1.5 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain CbiG_N PF11760.3 KOO33894.1 - 0.15 11.7 6.1 11 5.8 0.1 3.6 2 1 1 3 3 3 0 Cobalamin synthesis G N-terminal Phage_integ_N PF09003.5 KOO33894.1 - 1.5 8.5 4.1 20 4.9 0.0 3.0 3 0 0 3 3 3 0 Bacteriophage lambda integrase, N-terminal domain Proteasome PF00227.21 KOO33895.1 - 9.5e-46 155.4 0.6 1.4e-45 154.9 0.4 1.3 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.3 KOO33895.1 - 0.0048 16.1 0.2 0.0048 16.1 0.1 1.9 2 0 0 2 2 2 1 Proteasome beta subunits C terminal Trehalase PF01204.13 KOO33896.1 - 1.2e-07 30.7 0.1 3.5e-06 25.9 0.1 2.6 2 1 0 2 2 2 2 Trehalase DAGAT PF03982.8 KOO33897.1 - 2.1e-41 141.5 0.1 2.9e-41 141.1 0.1 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Glyco_transf_8 PF01501.15 KOO33897.1 - 0.14 11.5 0.0 0.25 10.6 0.0 1.5 2 0 0 2 2 2 0 Glycosyl transferase family 8 bZIP_Maf PF03131.12 KOO33899.1 - 0.056 13.7 3.1 0.065 13.5 2.1 1.2 1 1 0 1 1 1 0 bZIP Maf transcription factor SNN_linker PF09050.5 KOO33899.1 - 0.61 9.6 0.1 0.61 9.6 0.1 2.1 3 0 0 3 3 3 0 Stannin unstructured linker NTP_transf_2 PF01909.18 KOO33900.1 - 6e-07 29.7 0.0 1.3e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Pribosyltran PF00156.22 KOO33901.1 - 1.1e-12 47.7 0.1 1.3e-12 47.4 0.1 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain M16C_assoc PF08367.6 KOO33902.1 - 2.4e-46 157.6 0.0 4.4e-46 156.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.16 KOO33902.1 - 5.7e-15 55.4 0.0 3.5e-09 36.6 0.0 2.6 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 KOO33902.1 - 9.4e-06 25.4 0.0 3e-05 23.8 0.0 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Pkinase PF00069.20 KOO33903.1 - 2.2e-17 63.1 0.0 2.7e-17 62.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33903.1 - 2.5e-05 23.5 0.0 3.1e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO33903.1 - 0.0014 18.4 1.1 0.3 10.7 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family EF-hand_1 PF00036.27 KOO33904.1 - 1.2e-11 43.0 2.4 3.9e-05 22.6 0.0 4.0 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.1 KOO33904.1 - 3.4e-11 43.0 0.0 3.4e-11 43.0 0.0 2.2 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO33904.1 - 6e-10 38.1 0.1 3.1e-06 26.5 0.0 3.3 3 1 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.1 KOO33904.1 - 0.0034 16.6 0.9 0.05 12.9 0.0 2.9 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.1 KOO33904.1 - 0.022 14.3 3.5 3.7 7.2 0.1 3.6 3 1 1 4 4 4 0 EF-hand domain pair VCBS PF13517.1 KOO33904.1 - 0.039 14.3 0.2 2.7 8.3 0.0 2.6 3 0 0 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella AhpC-TSA_2 PF13911.1 KOO33907.1 - 1.3e-05 25.0 0.0 4.4e-05 23.3 0.0 1.9 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme DUF552 PF04472.7 KOO33907.1 - 0.097 12.6 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF552) IQ PF00612.22 KOO33908.1 - 0.00042 19.6 0.3 0.00042 19.6 0.2 2.8 3 0 0 3 3 3 1 IQ calmodulin-binding motif PX PF00787.19 KOO33908.1 - 0.00043 20.0 0.0 0.0013 18.5 0.0 1.7 1 1 1 2 2 2 1 PX domain ABC_membrane PF00664.18 KOO33909.1 - 3.8e-44 151.1 0.5 1.4e-22 80.3 0.5 2.7 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.22 KOO33909.1 - 1.2e-16 61.3 0.1 4.4e-12 46.4 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 KOO33909.1 - 0.0077 15.4 0.1 3.9 6.6 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 KOO33909.1 - 0.016 15.2 0.0 3.8 7.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.18 KOO33909.1 - 0.24 11.2 0.2 0.4 10.5 0.1 1.3 1 0 0 1 1 1 0 Dynamin family AAA_23 PF13476.1 KOO33909.1 - 0.93 9.7 0.0 1.5 9.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain Phosphoesterase PF04185.9 KOO33910.1 - 1.4e-51 175.8 0.1 1e-50 173.0 0.1 2.2 1 1 0 1 1 1 1 Phosphoesterase family Pkinase PF00069.20 KOO33911.1 - 3.8e-23 81.9 0.0 6.5e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33911.1 - 1.5e-13 50.4 0.0 2.9e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO33911.1 - 1.7e-05 23.9 0.3 7.9e-05 21.8 0.1 2.2 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Ion_trans_2 PF07885.11 KOO33912.1 - 3.8e-37 125.8 29.8 9.2e-11 41.3 1.5 4.5 4 0 0 4 4 4 4 Ion channel IRK PF01007.15 KOO33912.1 - 0.41 9.3 5.2 0.29 9.8 1.0 2.1 2 0 0 2 2 2 0 Inward rectifier potassium channel Ank_2 PF12796.2 KOO33913.1 - 4.1e-76 251.3 29.9 7.8e-18 64.6 0.3 5.2 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.25 KOO33913.1 - 2.5e-45 150.0 42.3 0.00016 21.2 0.0 11.1 11 0 0 11 11 11 11 Ankyrin repeat Ank_5 PF13857.1 KOO33913.1 - 1.4e-43 145.9 27.0 5.5e-08 32.8 0.3 10.1 1 1 10 11 11 11 10 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO33913.1 - 1.7e-42 143.0 7.9 3.8e-07 30.4 0.0 7.6 5 4 4 9 9 9 9 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO33913.1 - 2.6e-18 64.3 13.4 0.26 11.6 0.0 11.0 11 0 0 11 11 11 4 Ankyrin repeat DUF4182 PF13790.1 KOO33913.1 - 0.00017 21.2 7.9 0.71 9.7 0.0 5.5 6 0 0 6 6 6 2 Domain of unknown function (DUF4182) LTD PF00932.14 KOO33913.1 - 0.048 13.7 1.1 11 6.1 0.0 3.9 2 2 2 4 4 4 0 Lamin Tail Domain TIP_N PF12457.3 KOO33914.1 - 0.021 14.8 1.3 20 5.3 0.0 4.1 4 2 0 4 4 4 0 Tuftelin interacting protein N terminal Ufm1 PF03671.9 KOO33914.1 - 0.037 13.7 0.9 3.4 7.4 0.0 3.2 3 0 0 3 3 3 0 Ubiquitin fold modifier 1 protein tRNA_synt_1c_R1 PF04558.10 KOO33914.1 - 0.11 12.0 0.0 35 3.8 0.0 3.1 3 0 0 3 3 3 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 Nucleotid_trans PF03407.11 KOO33916.1 - 0.00049 19.9 0.0 0.7 9.6 0.0 2.2 2 0 0 2 2 2 2 Nucleotide-diphospho-sugar transferase Acetyltransf_6 PF13480.1 KOO33918.1 - 0.067 13.1 0.2 0.14 12.0 0.0 1.6 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain Zip PF02535.17 KOO33919.1 - 1.5e-08 34.0 17.3 6.7e-07 28.6 6.3 2.6 2 1 0 2 2 2 2 ZIP Zinc transporter DUF1453 PF07301.6 KOO33919.1 - 0.92 9.3 6.0 0.1 12.4 0.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1453) GSHPx PF00255.14 KOO33920.1 - 3.6e-37 126.0 0.0 5.3e-37 125.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione peroxidase ShK PF01549.19 KOO33920.1 - 1.6e-08 34.7 5.5 3.2e-08 33.7 3.8 1.5 1 0 0 1 1 1 1 ShK domain-like mRNA_cap_enzyme PF01331.14 KOO33922.1 - 2.3e-31 108.9 0.0 4.6e-16 59.0 0.0 3.0 2 1 0 2 2 2 2 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.10 KOO33922.1 - 2.4e-12 47.0 0.2 1e-07 32.2 0.0 2.2 2 0 0 2 2 2 2 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.16 KOO33922.1 - 0.00055 19.3 0.0 0.001 18.5 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain LRR_8 PF13855.1 KOO33923.1 - 1.7e-11 43.6 2.0 0.0097 15.6 0.0 4.9 4 1 2 6 6 6 4 Leucine rich repeat LRR_1 PF00560.28 KOO33923.1 - 1.8e-10 39.3 3.2 1.4 9.2 0.0 8.8 9 0 0 9 9 9 1 Leucine Rich Repeat LRR_4 PF12799.2 KOO33923.1 - 4.4e-08 32.5 0.3 0.08 12.5 0.1 5.1 4 2 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO33923.1 - 0.091 12.8 2.3 72 3.9 0.0 5.1 7 0 0 7 7 7 0 Leucine Rich repeat CIA30 PF08547.7 KOO33924.1 - 3.7e-33 114.5 0.0 4.3e-33 114.3 0.0 1.0 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) Peptidase_C1 PF00112.18 KOO33925.1 - 7.2e-43 147.0 2.8 1.1e-42 146.3 1.9 1.2 1 0 0 1 1 1 1 Papain family cysteine protease TraB PF01963.12 KOO33926.1 - 4.5e-07 29.5 0.1 1.1e-06 28.2 0.0 1.8 1 1 0 1 1 1 1 TraB family Fasciclin PF02469.17 KOO33927.1 - 1.5e-35 122.0 0.0 2.4e-35 121.3 0.0 1.4 1 0 0 1 1 1 1 Fasciclin domain PseudoU_synth_2 PF00849.17 KOO33928.1 - 3.1e-26 92.1 0.0 4.3e-26 91.6 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase Peptidase_M41 PF01434.13 KOO33929.1 - 7.3e-63 211.8 0.0 1.1e-62 211.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 KOO33929.1 - 4.5e-42 143.3 0.0 1.4e-41 141.8 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Exo_endo_phos PF03372.18 KOO33929.1 - 3.9e-18 66.2 0.0 1.8e-17 64.1 0.0 2.0 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family EF-hand_6 PF13405.1 KOO33929.1 - 7.8e-15 53.3 9.8 0.00013 21.5 0.1 4.8 5 0 0 5 5 4 3 EF-hand domain EF-hand_1 PF00036.27 KOO33929.1 - 2.1e-13 48.5 12.9 5.7e-05 22.1 0.2 5.2 5 0 0 5 5 4 3 EF hand EF-hand_7 PF13499.1 KOO33929.1 - 1.5e-12 47.4 2.8 2.2e-08 34.1 0.4 3.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO33929.1 - 1.6e-10 39.8 11.9 0.00078 18.6 0.6 4.6 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO33929.1 - 2.8e-07 30.0 3.9 0.0046 16.5 0.1 4.1 3 0 0 3 3 3 2 EF-hand domain pair Exo_endo_phos_2 PF14529.1 KOO33929.1 - 0.00014 21.4 0.0 0.0004 19.9 0.0 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase AAA_17 PF13207.1 KOO33929.1 - 0.00057 20.6 0.2 0.0042 17.8 0.0 2.6 3 0 0 3 3 1 1 AAA domain AAA_33 PF13671.1 KOO33929.1 - 0.0018 18.1 0.1 0.019 14.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.8 KOO33929.1 - 0.0066 15.2 0.1 0.011 14.4 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus RuvB_N PF05496.7 KOO33929.1 - 0.0094 15.0 0.0 0.028 13.4 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 KOO33929.1 - 0.029 14.4 0.0 0.33 11.1 0.0 2.7 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 KOO33929.1 - 0.032 13.9 0.2 0.032 13.9 0.2 2.6 3 0 0 3 3 1 0 Part of AAA domain AAA_2 PF07724.9 KOO33929.1 - 0.034 14.0 0.0 0.085 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 KOO33929.1 - 0.036 14.0 0.2 0.67 9.9 0.0 3.1 2 1 1 3 3 3 0 AAA ATPase domain SPARC_Ca_bdg PF10591.4 KOO33929.1 - 0.036 14.0 0.2 0.33 10.9 0.0 2.3 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.8 KOO33929.1 - 0.047 13.2 0.0 0.49 9.9 0.0 2.2 2 0 0 2 2 2 0 Caleosin related protein AAA_28 PF13521.1 KOO33929.1 - 0.06 13.3 0.0 0.18 11.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 KOO33929.1 - 0.067 12.9 1.3 0.4 10.3 0.1 2.8 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) 4HB_MCP_1 PF12729.2 KOO33929.1 - 0.091 12.1 0.1 0.24 10.7 0.0 1.6 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction IstB_IS21 PF01695.12 KOO33929.1 - 0.12 11.8 0.1 0.27 10.6 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Zeta_toxin PF06414.7 KOO33929.1 - 0.12 11.4 0.8 2 7.4 0.1 2.8 3 0 0 3 3 3 0 Zeta toxin Mg_chelatase PF01078.16 KOO33929.1 - 0.13 11.3 0.1 0.28 10.3 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DnaJ PF00226.26 KOO33930.1 - 1e-07 31.5 0.2 3.4e-07 29.8 0.1 2.1 1 1 0 1 1 1 1 DnaJ domain SpoIIIAH PF12685.2 KOO33930.1 - 0.076 12.4 0.3 0.094 12.2 0.2 1.3 1 1 0 1 1 1 0 SpoIIIAH-like protein IL4 PF00727.13 KOO33930.1 - 0.1 12.4 0.1 0.17 11.7 0.1 1.3 1 0 0 1 1 1 0 Interleukin 4 VIT1 PF01988.14 KOO33930.1 - 0.68 9.3 3.2 0.87 9.0 2.2 1.1 1 0 0 1 1 1 0 VIT family Med15 PF09606.5 KOO33930.1 - 0.78 7.8 6.5 0.83 7.7 4.5 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RED_C PF07807.6 KOO33930.1 - 0.92 9.7 3.6 0.77 9.9 0.8 1.9 2 0 0 2 2 2 0 RED-like protein C-terminal region Atg14 PF10186.4 KOO33930.1 - 1.8 7.4 5.9 2.3 7.0 4.1 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 M_domain PF12938.2 KOO33930.1 - 2.9 7.6 6.3 1.4 8.6 2.7 1.6 1 1 1 2 2 2 0 M domain of GW182 C_GCAxxG_C_C PF09719.5 KOO33930.1 - 3.4 7.5 7.6 4.2 7.2 4.3 1.7 1 1 1 2 2 2 0 Putative redox-active protein (C_GCAxxG_C_C) 14-3-3 PF00244.15 KOO33931.1 - 5.3e-102 339.9 2.1 5.8e-102 339.7 1.4 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.1 KOO33931.1 - 0.09 12.7 5.3 1.1 9.3 0.3 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat Branch PF02485.16 KOO33932.1 - 5.2e-11 42.1 0.0 6.8e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Core-2/I-Branching enzyme RRM_1 PF00076.17 KOO33933.1 - 2.9e-85 279.8 2.0 1.6e-20 72.5 0.0 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO33933.1 - 2.5e-57 190.7 0.2 4e-14 52.3 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO33933.1 - 1.4e-45 152.8 0.2 2e-10 40.3 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.13 KOO33933.1 - 4e-31 106.4 3.0 3e-30 103.6 0.5 3.0 4 0 0 4 4 4 1 Poly-adenylate binding protein, unique domain Nup35_RRM_2 PF14605.1 KOO33933.1 - 0.00032 20.4 0.0 4.6 7.0 0.0 3.7 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif YflT PF11181.3 KOO33933.1 - 0.0098 16.0 0.2 2.7 8.1 0.0 2.5 2 0 0 2 2 2 1 Heat induced stress protein YflT CbiG_mid PF11761.3 KOO33933.1 - 0.017 15.3 0.0 5.7 7.2 0.0 2.6 2 0 0 2 2 2 0 Cobalamin biosynthesis central region OB_RNB PF08206.6 KOO33933.1 - 0.18 11.3 6.5 6.7 6.3 0.0 3.4 3 0 0 3 3 3 0 Ribonuclease B OB domain Nefa_Nip30_N PF10187.4 KOO33933.1 - 0.36 11.0 3.7 17 5.6 0.0 2.5 2 0 0 2 2 2 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 DUF164 PF02591.10 KOO33934.1 - 0.088 12.6 0.3 0.15 11.8 0.2 1.4 1 0 0 1 1 1 0 Putative zinc ribbon domain Arm PF00514.18 KOO33935.1 - 3.2e-185 594.6 173.8 7.7e-07 28.7 0.1 50.3 49 1 0 49 49 49 39 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO33935.1 - 1.2e-19 70.3 203.3 0.00033 20.8 4.5 23.2 10 5 13 23 23 23 14 HEAT repeats Arm_2 PF04826.8 KOO33935.1 - 6.7e-19 67.9 2.0 1.3 8.0 0.0 14.3 10 6 7 19 19 19 6 Armadillo-like V-ATPase_H_N PF03224.9 KOO33935.1 - 1.3e-10 40.9 0.3 2.4 7.2 0.0 8.3 6 3 1 7 7 7 4 V-ATPase subunit H Atx10homo_assoc PF09759.4 KOO33935.1 - 4.8e-08 32.6 0.5 1.6 8.4 0.0 8.1 7 1 1 8 8 8 2 Spinocerebellar ataxia type 10 protein domain Adaptin_N PF01602.15 KOO33935.1 - 2.4e-07 29.4 11.1 0.6 8.3 0.0 8.8 7 3 1 8 8 8 4 Adaptin N terminal region HEAT PF02985.17 KOO33935.1 - 6.1 7.2 70.2 3.7 7.8 0.0 19.9 22 1 0 22 22 22 0 HEAT repeat Avirulence PF03377.8 KOO33936.1 - 0.046 12.4 0.0 0.069 11.8 0.0 1.1 1 0 0 1 1 1 0 Xanthomonas avirulence protein, Avr/PthA zf-CCCH PF00642.19 KOO33936.1 - 0.62 9.8 4.3 5.1 6.9 3.3 2.2 2 1 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Pkinase PF00069.20 KOO33938.1 - 0.0036 16.4 0.0 0.0079 15.3 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.20 KOO33939.1 - 2.7e-35 121.7 0.0 3.2e-35 121.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO33939.1 - 1.4e-33 116.1 0.0 1.6e-33 115.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO33939.1 - 1.6e-05 23.9 0.0 2.1e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO33939.1 - 0.00018 21.3 1.1 0.00068 19.4 0.5 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Cellulase-like PF12876.2 KOO33939.1 - 0.0031 17.9 0.0 0.0055 17.1 0.0 1.4 1 0 0 1 1 1 1 Sugar-binding cellulase-like UCH PF00443.24 KOO33941.1 - 2.1e-36 125.4 0.0 2.5e-36 125.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOO33941.1 - 6.9e-24 84.8 0.0 8.8e-24 84.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase TIR_2 PF13676.1 KOO33943.1 - 1.2e-08 34.9 0.1 0.0026 17.8 0.0 2.8 2 0 0 2 2 2 2 TIR domain DUF4088 PF13317.1 KOO33944.1 - 0.058 12.7 0.1 0.09 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4088) C2 PF00168.25 KOO33946.1 - 7.3e-18 64.1 0.0 1.2e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 C2 domain Ion_trans PF00520.26 KOO33946.1 - 3.9e-12 45.8 2.3 3.9e-12 45.8 1.6 1.8 2 0 0 2 2 2 1 Ion transport protein Ion_trans_N PF08412.5 KOO33946.1 - 0.0048 16.1 0.0 0.032 13.5 0.0 2.3 2 0 0 2 2 2 1 Ion transport protein N-terminal Exo_endo_phos PF03372.18 KOO33948.1 - 7.9e-12 45.6 0.1 1.3e-11 44.9 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Abhydrolase_5 PF12695.2 KOO33948.1 - 1.7e-06 27.8 0.9 4.6e-06 26.4 0.7 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 KOO33948.1 - 1.7e-05 24.8 3.5 4.4e-05 23.4 2.5 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family UPF0227 PF05728.7 KOO33948.1 - 0.0014 18.3 0.0 0.0026 17.4 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Esterase PF00756.15 KOO33948.1 - 0.064 12.6 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Lipase_3 PF01764.20 KOO33948.1 - 0.13 11.9 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) DUF1680 PF07944.7 KOO33949.1 - 7e-61 206.0 0.0 3.1e-48 164.3 0.0 2.9 2 1 0 2 2 2 2 Putative glycosyl hydrolase of unknown function (DUF1680) PAN_1 PF00024.21 KOO33949.1 - 0.0026 17.4 0.3 0.0055 16.4 0.2 1.5 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.1 KOO33949.1 - 0.0026 17.4 0.4 0.0026 17.4 0.3 2.9 4 0 0 4 4 4 1 PAN domain FtsJ PF01728.14 KOO33950.1 - 5.4e-20 72.1 0.0 2.6e-19 69.8 0.0 2.0 1 1 0 1 1 1 1 FtsJ-like methyltransferase G-patch PF01585.18 KOO33950.1 - 5.9e-12 45.1 1.0 1.5e-11 43.9 0.7 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 KOO33950.1 - 0.047 13.5 0.2 0.047 13.5 0.1 2.3 2 0 0 2 2 2 0 DExH-box splicing factor binding site KGG PF10685.4 KOO33951.1 - 0.069 13.1 1.6 0.13 12.2 1.1 1.4 1 0 0 1 1 1 0 Stress-induced bacterial acidophilic repeat motif Ank_2 PF12796.2 KOO33953.1 - 1.9e-90 297.3 59.8 2.8e-19 69.2 1.3 6.4 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank PF00023.25 KOO33953.1 - 4.6e-48 158.7 64.7 7.7e-06 25.4 0.1 13.3 13 0 0 13 13 13 12 Ankyrin repeat Ank_4 PF13637.1 KOO33953.1 - 3.9e-47 157.8 15.2 1.1e-07 32.1 0.0 8.0 6 2 2 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO33953.1 - 4.7e-47 156.9 44.6 2.3e-06 27.6 0.7 11.8 1 1 11 12 12 12 11 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO33953.1 - 1.9e-25 86.3 28.7 0.018 15.2 0.0 12.0 12 0 0 12 12 12 10 Ankyrin repeat DUF4182 PF13790.1 KOO33953.1 - 3.7e-08 33.0 3.2 2.4 8.0 0.0 7.5 9 0 0 9 9 9 2 Domain of unknown function (DUF4182) Cupin_8 PF13621.1 KOO33954.1 - 1.4e-11 44.3 0.0 1.9e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.17 KOO33954.1 - 4.6e-11 42.9 0.0 1.2e-10 41.5 0.0 1.7 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_4 PF08007.7 KOO33954.1 - 0.01 15.1 0.0 0.016 14.4 0.0 1.4 2 0 0 2 2 2 0 Cupin superfamily protein Cupin_2 PF07883.6 KOO33954.1 - 0.026 14.0 0.0 0.11 12.0 0.0 1.9 2 0 0 2 2 2 0 Cupin domain RRM_1 PF00076.17 KOO33955.1 - 7.7e-16 57.4 0.0 3.1e-14 52.3 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO33955.1 - 1.4e-12 47.4 0.0 4.1e-12 45.8 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO33955.1 - 0.0021 17.8 0.0 0.0037 17.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nop14 PF04147.7 KOO33955.1 - 0.0049 14.8 2.2 0.0068 14.4 1.5 1.1 1 0 0 1 1 1 1 Nop14-like family TLD PF07534.11 KOO33956.1 - 8.6e-18 64.6 0.0 2.4e-17 63.1 0.0 1.6 1 1 0 1 1 1 1 TLD Nucleotid_trans PF03407.11 KOO33957.1 - 9.6e-33 113.7 0.0 1.4e-32 113.1 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Ank_2 PF12796.2 KOO33958.1 - 2.4e-24 85.4 0.0 1.3e-17 63.8 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO33958.1 - 2.7e-20 72.3 0.7 4.6e-11 42.9 0.0 3.3 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO33958.1 - 6.3e-19 66.7 0.1 2.3e-10 39.7 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.1 KOO33958.1 - 3.2e-15 55.8 3.2 3.7e-10 39.7 0.4 3.5 2 2 2 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO33958.1 - 2.8e-09 36.2 0.0 4.4e-06 26.4 0.0 4.2 4 0 0 4 4 4 1 Ankyrin repeat JmjC PF02373.17 KOO33961.1 - 6e-35 119.9 0.6 9.5e-35 119.2 0.4 1.3 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.12 KOO33961.1 - 5.9e-11 41.6 0.9 1e-10 40.9 0.7 1.4 1 0 0 1 1 1 1 jmjN domain MBD PF01429.14 KOO33961.1 - 0.0021 17.5 0.0 0.0046 16.4 0.0 1.5 1 0 0 1 1 1 1 Methyl-CpG binding domain PMSR PF01625.16 KOO33964.1 - 6.3e-46 156.0 0.1 7.7e-46 155.8 0.1 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Vsr PF03852.10 KOO33964.1 - 0.011 15.2 0.1 0.48 10.0 0.3 2.3 2 0 0 2 2 2 0 DNA mismatch endonuclease Vsr VWA_2 PF13519.1 KOO33966.1 - 2e-16 60.5 0.1 4.1e-16 59.5 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Mg_chelatase PF01078.16 KOO33966.1 - 1.5e-14 53.6 0.3 3.3e-09 36.2 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI MCM PF00493.18 KOO33966.1 - 4.2e-08 32.3 0.0 4.2e-07 29.0 0.0 2.6 2 1 0 2 2 2 1 MCM2/3/5 family VWA PF00092.23 KOO33966.1 - 2e-07 30.9 0.0 1.4e-06 28.1 0.0 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain Sigma54_activat PF00158.21 KOO33966.1 - 4.7e-06 26.1 0.0 0.0034 16.8 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_5 PF07728.9 KOO33966.1 - 0.00011 21.9 0.0 0.0044 16.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) VWA_3 PF13768.1 KOO33966.1 - 0.00012 21.8 0.0 0.00027 20.6 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain Sigma54_activ_2 PF14532.1 KOO33966.1 - 0.011 15.7 0.0 2.1 8.4 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain VWA_CoxE PF05762.9 KOO33966.1 - 0.033 13.3 0.1 0.067 12.3 0.0 1.5 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein DUF2828 PF11443.3 KOO33966.1 - 0.1 10.7 0.0 0.17 10.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF3834 PF12916.2 KOO33966.1 - 0.16 10.9 0.8 0.56 9.1 0.1 2.3 2 2 1 3 3 3 0 Protein of unknown function (DUF3834) 4HBT_3 PF13622.1 KOO33966.1 - 0.65 9.6 9.4 2.1 8.0 6.4 1.9 1 1 0 1 1 1 0 Thioesterase-like superfamily SPRY PF00622.23 KOO33967.1 - 3.4e-27 94.9 0.5 1e-12 48.2 0.0 4.7 4 1 0 4 4 4 3 SPRY domain PKD_channel PF08016.7 KOO33967.1 - 2.5e-21 75.6 8.0 9.2e-21 73.7 5.6 1.9 1 1 0 1 1 1 1 Polycystin cation channel ATP-gua_Ptrans PF00217.14 KOO33967.1 - 4.1e-15 55.7 0.0 9.9e-11 41.4 0.0 2.4 2 0 0 2 2 2 2 ATP:guanido phosphotransferase, C-terminal catalytic domain DUF3645 PF12359.3 KOO33967.1 - 6.1e-15 54.0 0.2 2.6e-14 52.0 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3645) LRR_6 PF13516.1 KOO33967.1 - 2.5e-12 45.4 8.6 0.012 15.5 0.2 7.2 6 0 0 6 6 6 2 Leucine Rich repeat Ank_2 PF12796.2 KOO33967.1 - 1.3e-10 41.4 0.0 2.7e-09 37.2 0.0 2.8 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) DUF3638 PF12340.3 KOO33967.1 - 1.3e-10 40.6 0.0 3.2e-09 36.1 0.0 2.7 1 1 0 1 1 1 1 Protein of unknown function (DUF3638) Ank PF00023.25 KOO33967.1 - 2.3e-08 33.4 1.9 6.1e-05 22.6 0.0 4.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOO33967.1 - 9.8e-08 32.3 1.3 4.6e-06 27.0 0.0 3.9 3 1 1 4 4 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO33967.1 - 6.3e-07 29.4 3.4 0.00097 19.3 0.0 3.6 4 0 0 4 4 2 2 Ankyrin repeats (many copies) Ion_trans PF00520.26 KOO33967.1 - 1.7e-06 27.4 15.9 3e-06 26.6 11.0 1.4 1 0 0 1 1 1 1 Ion transport protein LRR_4 PF12799.2 KOO33967.1 - 6.7e-06 25.6 1.5 0.21 11.2 0.2 3.9 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) Ank_3 PF13606.1 KOO33967.1 - 1.6e-05 24.7 0.8 0.035 14.3 0.0 4.2 4 0 0 4 4 2 1 Ankyrin repeat CUB PF00431.15 KOO33967.1 - 0.066 13.2 0.0 0.23 11.5 0.0 1.9 1 0 0 1 1 1 0 CUB domain LRR_1 PF00560.28 KOO33967.1 - 0.12 12.5 1.0 74 3.9 0.0 4.7 4 1 0 4 4 4 0 Leucine Rich Repeat ATP-gua_PtransN PF02807.10 KOO33967.1 - 0.32 11.1 0.0 0.94 9.6 0.0 1.8 1 0 0 1 1 1 0 ATP:guanido phosphotransferase, N-terminal domain LRR_5 PF13306.1 KOO33969.1 - 1.8e-95 315.4 11.0 1.4e-39 134.7 1.5 3.0 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO33969.1 - 4e-35 119.3 0.2 1.4e-06 27.9 0.0 5.9 1 1 5 6 6 6 6 Leucine rich repeat He_PIG PF05345.7 KOO33969.1 - 0.0012 18.8 0.2 1.7e+02 2.3 0.0 6.0 6 0 0 6 6 6 0 Putative Ig domain SapA PF02199.10 KOO33969.1 - 0.11 12.2 11.2 4 7.2 0.1 4.0 4 0 0 4 4 4 0 Saposin A-type domain Fork_head_N PF08430.7 KOO33969.1 - 0.94 9.8 19.8 1.5e+04 -4.5 13.7 3.3 1 1 0 1 1 1 0 Forkhead N-terminal region NDUF_B7 PF05676.8 KOO33970.1 - 2.5e-27 94.0 2.1 3.3e-27 93.6 1.5 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.5 KOO33970.1 - 0.0069 16.1 0.1 0.011 15.5 0.1 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like 60KD_IMP PF02096.15 KOO33971.1 - 6.7e-34 117.2 0.0 1e-33 116.7 0.0 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein TPR_12 PF13424.1 KOO33971.1 - 2.8e-06 27.1 0.6 6.5e-06 26.0 0.4 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.1 KOO33971.1 - 0.015 15.1 4.0 0.028 14.3 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat LRR_6 PF13516.1 KOO33973.1 - 7.7e-21 71.7 10.4 0.02 14.9 0.1 9.4 9 0 0 9 9 9 5 Leucine Rich repeat LRR_1 PF00560.28 KOO33973.1 - 3.9e-05 23.1 4.9 12 6.4 0.0 7.4 9 1 0 9 9 9 1 Leucine Rich Repeat LRR_7 PF13504.1 KOO33973.1 - 4e-05 23.1 2.6 20 5.9 0.0 6.6 7 0 0 7 7 7 1 Leucine rich repeat LRR_4 PF12799.2 KOO33973.1 - 0.00073 19.0 5.4 9.7 5.9 0.0 5.2 4 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO33973.1 - 0.38 10.5 11.6 7.1 6.4 0.1 5.7 5 3 1 6 6 6 0 Leucine rich repeat ThiF PF00899.16 KOO33974.1 - 3.8e-33 114.1 2.1 6.9e-20 71.2 0.0 2.7 2 1 1 3 3 3 2 ThiF family UBACT PF02134.16 KOO33974.1 - 3.8e-32 109.6 0.0 9.4e-27 92.3 0.1 2.6 2 0 0 2 2 2 2 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 KOO33974.1 - 1.4e-16 59.6 0.0 3.4e-16 58.3 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site ResIII PF04851.10 KOO33976.1 - 4.8e-06 26.5 0.0 0.082 12.7 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit ADPrib_exo_Tox PF03496.9 KOO33976.1 - 5.6e-06 25.7 0.0 0.0031 16.7 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosyltransferase exoenzyme DEAD PF00270.24 KOO33976.1 - 0.00045 19.7 0.0 0.0031 17.0 0.0 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase DUF2075 PF09848.4 KOO33976.1 - 0.0057 15.6 0.0 0.0089 15.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) UvrD_C_2 PF13538.1 KOO33976.1 - 0.029 14.5 0.0 0.066 13.3 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_12 PF13087.1 KOO33976.1 - 0.03 13.6 0.0 0.058 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 KOO33976.1 - 0.12 11.5 0.0 0.23 10.6 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein zf-RAG1 PF10426.4 KOO33977.1 - 0.056 13.4 0.4 0.098 12.6 0.3 1.4 1 0 0 1 1 1 0 Recombination-activating protein 1 zinc-finger domain Beta_helix PF13229.1 KOO33978.1 - 9.9e-24 83.8 11.0 1.2e-12 47.8 1.9 2.4 1 1 1 2 2 2 2 Right handed beta helix region NosD PF05048.8 KOO33978.1 - 3.3e-15 55.9 0.4 1.4e-08 34.2 0.1 2.1 1 1 1 2 2 2 2 Periplasmic copper-binding protein (NosD) DUF1565 PF07602.6 KOO33978.1 - 0.001 18.2 4.9 0.031 13.4 3.4 2.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1565) F-box-like PF12937.2 KOO33978.1 - 2.5 7.8 4.4 0.39 10.4 0.2 1.8 2 0 0 2 2 2 0 F-box-like Methyltransf_31 PF13847.1 KOO33979.1 - 3.7e-10 39.6 0.0 4.5e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO33979.1 - 7.1e-09 35.5 0.0 1e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO33979.1 - 7.5e-09 35.9 0.0 1.5e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO33979.1 - 1.1e-08 35.5 0.1 2.5e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO33979.1 - 1.2e-07 32.0 0.0 2.7e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO33979.1 - 8.7e-07 29.2 0.0 1.8e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO33979.1 - 4.9e-06 26.5 0.8 1.4e-05 25.0 0.1 2.1 2 1 0 2 2 2 1 Methyltransferase domain FmrO PF07091.6 KOO33979.1 - 0.0024 16.9 0.0 0.004 16.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA methyltransferase (FmrO) MTS PF05175.9 KOO33979.1 - 0.0075 15.6 0.0 0.017 14.5 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain AdoMet_MTase PF07757.8 KOO33979.1 - 0.038 14.1 0.0 0.077 13.1 0.0 1.6 1 1 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase WD40 PF00400.27 KOO33980.1 - 1.8e-20 72.0 9.7 3.2e-10 39.4 1.1 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat Nucleoporin_N PF08801.6 KOO33980.1 - 0.044 12.5 0.0 4.4 5.9 0.0 2.1 2 0 0 2 2 2 0 Nup133 N terminal like ArfGap PF01412.13 KOO33981.1 - 3.4e-32 110.6 0.0 7.1e-32 109.6 0.0 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Ank_2 PF12796.2 KOO33981.1 - 6e-21 74.5 9.3 9.5e-13 48.3 1.2 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) PH PF00169.24 KOO33981.1 - 4.8e-19 68.4 0.0 1.6e-09 37.8 0.0 2.6 2 0 0 2 2 2 2 PH domain PH_11 PF15413.1 KOO33981.1 - 1.3e-09 38.2 0.4 0.0029 17.8 0.2 3.9 2 2 0 2 2 2 2 Pleckstrin homology domain Ank PF00023.25 KOO33981.1 - 1.2e-08 34.3 10.0 0.00013 21.5 0.1 4.3 4 0 0 4 4 4 2 Ankyrin repeat PH_8 PF15409.1 KOO33981.1 - 3.7e-08 33.3 0.1 9.7e-07 28.7 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain Ank_4 PF13637.1 KOO33981.1 - 1.1e-07 32.1 0.9 0.0078 16.6 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO33981.1 - 3.2e-06 27.1 4.9 7.5e-05 22.8 0.0 3.4 2 1 1 3 3 3 1 Ankyrin repeats (many copies) PH_3 PF14593.1 KOO33981.1 - 7.8e-05 22.5 0.0 0.0054 16.5 0.0 2.4 2 0 0 2 2 2 1 PH domain Ank_3 PF13606.1 KOO33981.1 - 0.00013 21.8 2.2 1.8 9.0 0.0 3.9 3 0 0 3 3 3 1 Ankyrin repeat Mcp5_PH PF12814.2 KOO33981.1 - 0.039 13.8 0.1 4.3 7.2 0.0 2.5 2 0 0 2 2 2 0 Meiotic cell cortex C-terminal pleckstrin homology PH_2 PF08458.5 KOO33981.1 - 0.05 13.5 0.1 0.51 10.3 0.0 2.2 2 0 0 2 2 2 0 Plant pleckstrin homology-like region LON PF02190.11 KOO33982.1 - 2.4e-05 24.0 0.0 0.0025 17.5 0.0 2.3 2 0 0 2 2 2 2 ATP-dependent protease La (LON) domain Dus PF01207.12 KOO33982.1 - 5.9e-05 22.0 0.0 9.8e-05 21.3 0.0 1.3 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) MSP1_C PF07462.6 KOO33982.1 - 6 5.1 4.3 11 4.2 3.0 1.3 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus IQ PF00612.22 KOO33983.1 - 2.4 8.0 23.7 1.7 8.4 0.6 5.0 3 1 2 5 5 5 0 IQ calmodulin-binding motif Matrilin_ccoil PF10393.4 KOO33984.1 - 0.04 13.2 0.8 0.069 12.5 0.6 1.4 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin Speriolin_N PF15058.1 KOO33984.1 - 0.12 12.2 5.1 0.13 12.1 3.5 1.2 1 0 0 1 1 1 0 Speriolin N terminus GcrA PF07750.6 KOO33984.1 - 0.15 12.2 3.6 0.17 12.0 2.5 1.1 1 0 0 1 1 1 0 GcrA cell cycle regulator DUF3138 PF11336.3 KOO33984.1 - 1.5 6.8 11.3 1.9 6.6 7.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) FKBP_C PF00254.23 KOO33985.1 - 1.5e-22 79.3 0.0 2.1e-22 78.9 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Tmemb_185A PF10269.4 KOO33988.1 - 6.7e-06 25.8 2.3 1.2e-05 25.0 1.6 1.3 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein ResIII PF04851.10 KOO33988.1 - 0.00064 19.6 0.0 1.3 8.8 0.0 2.3 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DUF2075 PF09848.4 KOO33988.1 - 0.0025 16.8 0.0 0.0043 16.0 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) UvrD_C_2 PF13538.1 KOO33988.1 - 0.0095 16.0 0.0 0.028 14.5 0.0 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain DEAD PF00270.24 KOO33988.1 - 0.012 15.1 0.0 0.033 13.6 0.0 1.7 1 0 0 1 1 1 0 DEAD/DEAH box helicase LAM_C PF12544.3 KOO33988.1 - 0.13 12.3 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 Lysine-2,3-aminomutase RAP1 PF07218.6 KOO33988.1 - 1.5 6.8 4.7 2.6 6.0 3.2 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Glyco_hydro_67N PF03648.9 KOO33989.1 - 0.17 11.8 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 N-terminus Tudor-knot PF11717.3 KOO33990.1 - 6.3e-22 77.0 8.7 0.00037 20.1 0.1 5.6 6 0 0 6 6 6 4 RNA binding activity-knot of a chromodomain AAA_16 PF13191.1 KOO33990.1 - 8.7e-08 32.3 0.2 8.7e-08 32.3 0.2 3.4 2 1 0 2 2 2 1 AAA ATPase domain MBT PF02820.13 KOO33990.1 - 7e-07 29.0 0.1 0.2 11.6 0.0 4.5 4 0 0 4 4 4 1 mbt repeat AAA_22 PF13401.1 KOO33990.1 - 2.7e-06 27.5 0.1 2e-05 24.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain Cdc6_C PF09079.6 KOO33990.1 - 8.8e-05 22.1 0.4 0.0002 20.9 0.0 1.8 2 0 0 2 2 2 1 CDC6, C terminal Agenet PF05641.7 KOO33990.1 - 0.00092 19.3 3.6 19 5.5 0.0 4.5 4 0 0 4 4 4 2 Agenet domain AAA PF00004.24 KOO33990.1 - 0.061 13.5 0.2 11 6.2 0.0 3.1 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Melibiase PF02065.13 KOO33993.1 - 0.0012 17.6 0.0 0.002 16.8 0.0 1.3 1 0 0 1 1 1 1 Melibiase HMG_box PF00505.14 KOO33994.1 - 1.5e-05 25.2 0.1 1.5e-05 25.2 0.0 3.3 3 1 0 3 3 3 1 HMG (high mobility group) box TFIIA PF03153.8 KOO33994.1 - 5 6.9 8.8 6.2 6.6 6.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hex_IIIa PF02455.11 KOO33994.1 - 8 5.0 8.8 9.4 4.7 6.1 1.1 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) FKBP_C PF00254.23 KOO33995.1 - 9.5e-18 64.0 0.0 1.2e-17 63.6 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase PsbQ PF05757.6 KOO33995.1 - 0.13 11.6 0.3 0.2 11.0 0.2 1.2 1 0 0 1 1 1 0 Oxygen evolving enhancer protein 3 (PsbQ) LRR_6 PF13516.1 KOO33996.1 - 4.7e-07 29.2 0.0 1.5 9.1 0.0 4.7 5 0 0 5 5 5 3 Leucine Rich repeat LRR_7 PF13504.1 KOO33996.1 - 0.00031 20.4 0.2 75 4.2 0.0 5.5 6 0 0 6 6 6 0 Leucine rich repeat LRR_1 PF00560.28 KOO33996.1 - 0.12 12.4 0.0 51 4.4 0.0 3.8 4 0 0 4 4 4 0 Leucine Rich Repeat EF-hand_7 PF13499.1 KOO33997.1 - 6.1e-23 80.7 12.5 0.0011 18.9 0.0 7.1 5 2 2 7 7 7 7 EF-hand domain pair EF-hand_6 PF13405.1 KOO33997.1 - 8.5e-23 78.1 14.7 0.00027 20.5 0.4 7.4 7 0 0 7 7 7 5 EF-hand domain EF-hand_1 PF00036.27 KOO33997.1 - 1.5e-21 73.9 14.1 0.00047 19.2 0.1 7.4 7 0 0 7 7 7 5 EF hand EF-hand_8 PF13833.1 KOO33997.1 - 4.2e-09 35.8 16.5 0.012 15.1 0.1 6.1 3 3 3 6 6 6 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO33997.1 - 1.1e-07 30.8 17.7 0.016 14.5 0.3 5.7 5 0 0 5 5 5 3 EF hand Endonuc-dimeris PF09124.5 KOO33997.1 - 0.057 13.0 0.1 6.1 6.5 0.0 2.7 2 0 0 2 2 2 0 T4 recombination endonuclease VII, dimerisation MAT1 PF06391.8 KOO33997.1 - 0.11 12.0 7.7 2 7.9 0.8 2.3 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 EF-hand_4 PF12763.2 KOO33997.1 - 0.55 9.9 11.8 1.2 8.9 0.1 4.9 4 2 1 5 5 5 0 Cytoskeletal-regulatory complex EF hand Zip PF02535.17 KOO33999.1 - 5.3e-21 74.9 14.4 8.2e-19 67.7 7.4 2.2 1 1 1 2 2 2 2 ZIP Zinc transporter Na_Ca_ex PF01699.19 KOO34002.1 - 4e-31 107.4 24.5 8.9e-17 61.0 4.7 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein LRR_4 PF12799.2 KOO34003.1 - 4e-22 77.3 47.9 6.6e-07 28.8 1.3 10.5 9 2 2 11 11 11 7 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO34003.1 - 7.8e-13 47.0 48.4 0.018 15.0 0.1 16.2 15 1 1 16 16 16 4 Leucine Rich repeat LRR_8 PF13855.1 KOO34003.1 - 8e-11 41.5 43.8 2.7e-06 27.0 2.5 8.4 7 2 1 8 8 8 3 Leucine rich repeat LRR_1 PF00560.28 KOO34003.1 - 5.9e-07 28.6 35.0 0.38 10.9 0.3 13.6 16 0 0 16 16 16 3 Leucine Rich Repeat Ras PF00071.17 KOO34003.1 - 0.012 15.0 0.0 0.029 13.7 0.0 1.7 1 0 0 1 1 1 0 Ras family LRR_7 PF13504.1 KOO34003.1 - 0.013 15.5 32.5 10 6.8 0.0 12.0 14 0 0 14 14 14 0 Leucine rich repeat DUF1049 PF06305.6 KOO34005.1 - 0.058 12.8 2.6 0.089 12.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) RseC_MucC PF04246.7 KOO34005.1 - 0.32 10.5 2.2 0.28 10.7 0.2 1.7 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC efThoc1 PF11957.3 KOO34007.1 - 2.1e-87 293.7 0.0 2.8e-87 293.2 0.0 1.1 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Pkinase PF00069.20 KOO34008.1 - 2.7e-35 121.7 0.0 8.2e-32 110.3 0.0 2.4 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34008.1 - 1e-19 70.6 0.0 2.7e-19 69.2 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase PABP PF00658.13 KOO34008.1 - 1.5e-13 50.2 0.1 3.9e-13 48.8 0.1 1.7 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain zf-RING_2 PF13639.1 KOO34008.1 - 0.00043 20.0 1.2 0.0015 18.3 0.8 2.0 1 0 0 1 1 1 1 Ring finger domain Kinase-like PF14531.1 KOO34008.1 - 0.014 14.4 0.0 0.026 13.5 0.0 1.4 1 0 0 1 1 1 0 Kinase-like zf-C3HC4 PF00097.20 KOO34008.1 - 0.025 14.2 0.3 0.071 12.7 0.2 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO34008.1 - 0.16 12.0 0.8 0.5 10.4 0.6 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF3431 PF11913.3 KOO34009.1 - 3e-12 46.4 0.1 3.6e-06 26.6 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF3431) Caps_synth PF05704.7 KOO34009.1 - 1.2e-10 40.9 0.3 2.7e-10 39.8 0.0 1.7 2 0 0 2 2 2 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.10 KOO34009.1 - 0.0033 17.7 0.0 0.0084 16.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif 14-3-3 PF00244.15 KOO34010.1 - 1.6e-88 295.7 1.8 1.9e-88 295.5 1.3 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.1 KOO34010.1 - 0.081 12.8 3.2 2.5 8.1 0.4 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO34010.1 - 0.16 11.8 1.0 27 4.8 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Anoctamin PF04547.7 KOO34011.1 - 1.9e-99 333.3 0.0 2.6e-99 332.8 0.0 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel Actin PF00022.14 KOO34012.1 - 7.5e-31 106.9 0.0 6.7e-30 103.7 0.0 2.1 1 1 1 2 2 2 1 Actin EF-hand_1 PF00036.27 KOO34014.1 - 8.7e-11 40.3 0.4 1.8e-06 26.8 0.2 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO34014.1 - 7.5e-10 38.8 0.5 4.2e-08 33.2 0.1 1.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO34014.1 - 1.6e-09 36.8 0.5 2.5e-05 23.7 0.2 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO34014.1 - 2.9e-07 29.5 1.0 0.00024 20.2 0.3 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO34014.1 - 9.9e-07 28.2 2.4 0.003 17.1 1.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair DUF2309 PF10070.4 KOO34015.1 - 5.9e-142 474.4 0.0 1.2e-135 453.6 0.0 2.5 1 1 1 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2309) Pentapeptide_4 PF13599.1 KOO34017.1 - 2.2e-42 142.7 0.0 1.3e-07 31.3 0.0 9.4 3 3 7 10 10 10 10 Pentapeptide repeats (9 copies) DUF2639 PF11121.3 KOO34017.1 - 0.0013 18.1 0.2 26 4.4 0.0 6.2 5 0 0 5 5 5 1 Protein of unknown function (DUF2639) XK-related PF09815.4 KOO34017.1 - 1.2 8.0 9.7 4.3 6.2 6.7 1.8 1 1 0 1 1 1 0 XK-related protein STAS PF01740.16 KOO34018.1 - 5.2e-06 25.8 0.2 2.2e-05 23.8 0.2 2.0 1 1 0 1 1 1 1 STAS domain STAS_2 PF13466.1 KOO34018.1 - 0.011 15.7 3.4 0.017 15.1 0.1 2.8 3 0 0 3 3 3 0 STAS domain cNMP_binding PF00027.24 KOO34018.1 - 0.023 14.4 0.0 0.053 13.3 0.0 1.6 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain CLN3 PF02487.12 KOO34019.1 - 9.4e-16 57.5 0.0 1.6e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 CLN3 protein Ion_trans PF00520.26 KOO34019.1 - 0.16 11.1 0.6 0.37 9.9 0.2 1.7 1 1 0 1 1 1 0 Ion transport protein Nodulin_late PF07127.6 KOO34020.1 - 0.12 12.5 0.5 0.22 11.6 0.3 1.4 1 0 0 1 1 1 0 Late nodulin protein EF-hand_7 PF13499.1 KOO34021.1 - 4.4e-24 84.3 4.6 9.9e-06 25.6 0.0 4.5 3 1 0 4 4 4 4 EF-hand domain pair LRR_6 PF13516.1 KOO34021.1 - 3.4e-21 72.8 8.5 0.022 14.8 0.0 8.0 7 0 0 7 7 7 7 Leucine Rich repeat EF-hand_6 PF13405.1 KOO34021.1 - 7.2e-20 69.0 6.9 0.00014 21.4 0.0 7.7 7 0 0 7 7 7 5 EF-hand domain EF-hand_1 PF00036.27 KOO34021.1 - 3.3e-18 63.5 0.0 0.27 10.6 0.0 7.6 7 0 0 7 7 7 6 EF hand EF-hand_5 PF13202.1 KOO34021.1 - 4.8e-11 41.4 4.8 0.094 12.0 0.0 7.4 7 0 0 7 7 7 2 EF hand EF-hand_8 PF13833.1 KOO34021.1 - 2.3e-10 39.9 0.1 0.09 12.4 0.0 5.3 5 1 1 6 6 6 3 EF-hand domain pair LRR_4 PF12799.2 KOO34021.1 - 4.7e-10 38.8 0.0 0.035 13.7 0.0 4.9 3 1 3 6 6 6 5 Leucine Rich repeats (2 copies) Anoctamin PF04547.7 KOO34022.1 - 1.1e-110 370.3 2.9 1.4e-110 370.1 2.0 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel DUF1672 PF07901.6 KOO34022.1 - 0.059 12.3 0.0 0.094 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1672) IQ PF00612.22 KOO34023.1 - 0.00021 20.6 17.1 0.028 14.0 2.2 4.1 3 0 0 3 3 3 2 IQ calmodulin-binding motif Glyco_hydro_31 PF01055.21 KOO34026.1 - 4.1e-32 111.5 9.7 2e-30 106.0 6.7 2.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 DUF3584 PF12128.3 KOO34027.1 - 0.053 10.8 5.3 0.092 10.0 3.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) NYD-SP28 PF14772.1 KOO34027.1 - 0.52 10.4 4.4 0.95 9.5 0.3 2.9 3 1 0 3 3 3 0 Sperm tail TMF_DNA_bd PF12329.3 KOO34027.1 - 6.2 6.7 8.1 2.3 8.0 0.3 3.6 3 1 1 4 4 4 0 TATA element modulatory factor 1 DNA binding LRR_6 PF13516.1 KOO34028.1 - 6e-22 75.2 39.3 0.029 14.4 0.0 14.9 16 0 0 16 16 16 8 Leucine Rich repeat LRR_1 PF00560.28 KOO34028.1 - 1.6e-15 54.7 14.8 0.74 10.0 0.0 10.6 11 0 0 11 11 11 5 Leucine Rich Repeat LRR_4 PF12799.2 KOO34028.1 - 1.6e-08 33.9 24.4 0.067 12.8 0.4 7.6 8 1 0 8 8 8 4 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO34028.1 - 1.7e-07 30.2 26.9 3.1 8.4 0.2 10.1 10 0 0 10 10 10 3 Leucine rich repeat LRR_8 PF13855.1 KOO34028.1 - 1.6e-05 24.5 18.4 11 5.8 2.1 8.7 8 3 0 8 8 8 2 Leucine rich repeat FIBP PF05427.6 KOO34028.1 - 0.0039 16.4 0.0 2.2 7.4 0.0 2.2 2 0 0 2 2 2 2 Acidic fibroblast growth factor binding (FIBP) EF-hand_1 PF00036.27 KOO34030.1 - 1.1e-05 24.3 0.1 1.9e-05 23.6 0.1 1.4 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO34030.1 - 8.7e-05 22.0 0.0 0.00017 21.1 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 KOO34030.1 - 0.0013 18.8 0.0 0.0021 18.1 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO34030.1 - 0.0018 17.5 0.1 0.0037 16.5 0.0 1.4 1 0 0 1 1 1 1 EF hand OGFr_N PF04664.8 KOO34033.1 - 0.16 11.2 0.0 0.21 10.8 0.0 1.1 1 0 0 1 1 1 0 Opioid growth factor receptor (OGFr) conserved region U-box PF04564.10 KOO34034.1 - 5.1e-10 39.1 0.0 7.9e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 U-box domain OmpH PF03938.9 KOO34034.1 - 0.027 14.4 0.8 0.034 14.0 0.6 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) HR1 PF02185.11 KOO34034.1 - 0.05 13.3 1.0 0.089 12.5 0.7 1.5 1 0 0 1 1 1 0 Hr1 repeat Filament PF00038.16 KOO34034.1 - 0.068 12.6 2.9 0.11 11.9 2.0 1.3 1 0 0 1 1 1 0 Intermediate filament protein Mei5 PF10376.4 KOO34034.1 - 0.098 12.1 0.8 0.16 11.4 0.6 1.3 1 0 0 1 1 1 0 Double-strand recombination repair protein Peripla_BP_2 PF01497.13 KOO34034.1 - 0.15 11.1 2.2 1 8.4 0.0 2.2 1 1 0 2 2 2 0 Periplasmic binding protein Arm PF00514.18 KOO34035.1 - 2e-38 128.9 28.0 9.6e-07 28.4 0.4 6.4 6 0 0 6 6 6 6 Armadillo/beta-catenin-like repeat U-box PF04564.10 KOO34035.1 - 2.7e-07 30.4 0.0 4.9e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO34035.1 - 4.6e-05 22.8 0.0 0.00011 21.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Succ_CoA_lig PF13607.1 KOO34035.1 - 0.011 15.3 30.2 0.3 10.6 0.9 5.9 1 1 4 6 6 6 0 Succinyl-CoA ligase like flavodoxin domain Atx10homo_assoc PF09759.4 KOO34035.1 - 0.032 13.9 1.7 3.3 7.4 0.0 4.0 2 2 2 4 4 4 0 Spinocerebellar ataxia type 10 protein domain ATP_transf PF09830.4 KOO34035.1 - 0.21 11.4 1.3 6.7 6.5 0.1 3.5 2 1 2 4 4 4 0 ATP adenylyltransferase TIG PF01833.19 KOO34038.1 - 2.6e-17 62.5 1.0 4.3e-11 42.6 0.7 2.8 2 0 0 2 2 2 2 IPT/TIG domain RdRP PF05183.7 KOO34040.1 - 1e-25 90.5 0.0 1.4e-25 90.0 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Radical_SAM PF04055.16 KOO34041.1 - 1.8e-14 54.2 0.0 3.1e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily GST_C_2 PF13410.1 KOO34041.1 - 0.3 11.0 2.3 4.1 7.3 0.6 2.8 1 1 1 2 2 2 0 Glutathione S-transferase, C-terminal domain Pkinase PF00069.20 KOO34046.1 - 0.0012 18.1 0.0 0.0015 17.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain DnaJ PF00226.26 KOO34048.1 - 7e-09 35.2 2.8 1.3e-08 34.4 0.4 2.2 2 0 0 2 2 2 1 DnaJ domain SR-25 PF10500.4 KOO34049.1 - 0.00076 19.0 9.8 0.0012 18.3 6.8 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein CDC45 PF02724.9 KOO34049.1 - 0.08 10.9 5.4 0.098 10.6 3.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF3827 PF12877.2 KOO34049.1 - 0.17 9.9 7.6 0.22 9.5 5.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Vfa1 PF08432.5 KOO34049.1 - 0.31 11.0 9.5 0.48 10.4 6.6 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RAP1 PF07218.6 KOO34049.1 - 0.32 9.0 3.9 0.39 8.7 2.7 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) TATR PF03430.8 KOO34049.1 - 0.34 9.4 5.1 0.4 9.2 3.5 1.1 1 0 0 1 1 1 0 Trans-activating transcriptional regulator RR_TM4-6 PF06459.7 KOO34049.1 - 0.71 9.7 6.4 0.96 9.2 4.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2058 PF09831.4 KOO34049.1 - 1.3 8.8 10.4 0.16 11.8 4.1 1.8 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2058) SAPS PF04499.10 KOO34049.1 - 2.9 6.4 9.6 5.5 5.4 5.2 1.9 1 1 1 2 2 2 0 SIT4 phosphatase-associated protein MRI PF15325.1 KOO34049.1 - 4.3 8.3 10.8 9.3 7.2 7.5 1.5 1 0 0 1 1 1 0 Modulator of retrovirus infection Sec62 PF03839.11 KOO34049.1 - 5.1 6.4 5.6 7.9 5.8 3.9 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 COPI_assoc PF08507.5 KOO34052.1 - 2.4e-06 27.3 6.8 3.7e-06 26.6 4.7 1.2 1 0 0 1 1 1 1 COPI associated protein EF-hand_7 PF13499.1 KOO34052.1 - 0.023 14.8 0.0 0.045 13.9 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.27 KOO34052.1 - 0.077 12.3 0.0 0.2 11.0 0.0 1.7 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.1 KOO34052.1 - 0.13 12.1 0.1 0.53 10.3 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain TPR_19 PF14559.1 KOO34054.1 - 1.1e-05 25.6 8.8 0.0021 18.3 2.6 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO34054.1 - 4.3e-05 23.0 10.0 0.06 12.9 0.7 4.2 3 1 1 4 4 4 2 TPR repeat TPR_17 PF13431.1 KOO34054.1 - 0.00042 20.2 1.9 2.6 8.4 0.2 3.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO34054.1 - 0.037 13.6 0.5 14 5.4 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO34054.1 - 0.12 12.3 2.7 6.6 6.9 0.3 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO34054.1 - 7.8 7.4 28.3 1.7 9.5 1.6 6.2 4 3 2 6 6 6 0 Tetratricopeptide repeat Pkinase PF00069.20 KOO34055.1 - 9.1e-35 120.0 0.0 1.3e-34 119.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34055.1 - 3.4e-30 104.9 0.0 4.8e-30 104.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase TIR_2 PF13676.1 KOO34055.1 - 8.4e-06 25.8 0.0 2e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 TIR domain APH PF01636.18 KOO34055.1 - 0.00044 20.0 2.1 0.025 14.2 0.9 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family Cellulase-like PF12876.2 KOO34055.1 - 0.017 15.5 0.0 0.04 14.3 0.0 1.6 1 0 0 1 1 1 0 Sugar-binding cellulase-like Kinase-like PF14531.1 KOO34055.1 - 0.017 14.1 0.0 0.027 13.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Phytochelatin PF05023.9 KOO34056.1 - 1.5e-64 216.8 0.0 1.8e-64 216.5 0.0 1.0 1 0 0 1 1 1 1 Phytochelatin synthase Arf PF00025.16 KOO34057.1 - 1.9e-70 235.6 0.3 2.1e-70 235.5 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.15 KOO34057.1 - 1.6e-12 46.8 0.6 2.3e-06 26.5 0.0 2.2 1 1 0 2 2 2 2 G-protein alpha subunit Ras PF00071.17 KOO34057.1 - 1.3e-11 44.1 0.0 1.6e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 KOO34057.1 - 1.6e-10 40.4 0.0 2.1e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 KOO34057.1 - 1.1e-09 37.8 0.0 1.2e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 KOO34057.1 - 1.2e-09 38.7 0.0 1.6e-09 38.2 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 KOO34057.1 - 1.1e-06 28.1 0.0 4.6e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOO34057.1 - 1.8e-06 27.8 0.0 2.4e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.4 KOO34057.1 - 0.068 12.6 0.2 0.25 10.8 0.0 1.9 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation DUF2089 PF09862.4 KOO34059.1 - 0.032 14.0 0.0 0.047 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) Sec3-PIP2_bind PF15277.1 KOO34059.1 - 0.075 12.9 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Exocyst complex component SEC3 N-terminal PIP2 binding PH BOP1NT PF08145.7 KOO34060.1 - 1.2e-93 313.6 4.6 1.5e-93 313.3 3.2 1.1 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.27 KOO34060.1 - 8.4e-35 117.4 7.9 2.2e-11 43.1 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat Apc4_WD40 PF12894.2 KOO34060.1 - 0.002 17.6 0.0 12 5.5 0.0 3.7 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.3 KOO34060.1 - 0.0027 15.9 0.0 0.004 15.3 0.0 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Prion PF00377.13 KOO34060.1 - 0.045 13.4 0.9 2.9 7.6 0.1 2.3 2 0 0 2 2 2 0 Prion/Doppel alpha-helical domain DUF3312 PF11768.3 KOO34060.1 - 0.092 10.9 0.0 0.31 9.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3312) NAD_binding_10 PF13460.1 KOO34061.1 - 1.4e-11 44.7 0.4 2.2e-11 44.1 0.3 1.3 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 KOO34061.1 - 2.7e-06 27.0 0.1 2.4e-05 23.9 0.1 2.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.14 KOO34061.1 - 0.00024 20.3 0.0 0.00043 19.4 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Arm PF00514.18 KOO34062.1 - 2.2e-126 407.9 159.6 9.4e-08 31.6 0.0 45.4 48 0 0 48 48 47 30 Armadillo/beta-catenin-like repeat EF-hand_7 PF13499.1 KOO34062.1 - 1.5e-20 73.1 4.6 1.2e-09 38.1 0.1 2.9 3 0 0 3 3 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO34062.1 - 5.8e-17 59.6 5.1 0.0015 17.6 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO34062.1 - 5.2e-14 50.7 3.1 0.0019 17.9 0.0 4.8 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.1 KOO34062.1 - 2.6e-10 39.7 3.9 0.00021 20.8 0.1 3.4 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO34062.1 - 1.5e-09 36.7 8.1 0.029 13.7 0.0 4.6 4 0 0 4 4 4 4 EF hand KAP PF05804.7 KOO34062.1 - 2.4e-08 32.3 0.0 2.5e-05 22.4 0.0 4.5 5 1 0 5 5 5 1 Kinesin-associated protein (KAP) Arm_2 PF04826.8 KOO34062.1 - 3.6e-07 29.5 10.1 4.3 6.3 0.0 9.7 7 4 3 11 11 11 1 Armadillo-like PH PF00169.24 KOO34062.1 - 2.2e-06 27.8 0.0 4.7e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 PH domain HEAT_2 PF13646.1 KOO34062.1 - 0.0011 19.2 9.4 0.0027 17.9 1.4 23.2 8 5 12 24 24 24 8 HEAT repeats Adaptin_N PF01602.15 KOO34062.1 - 0.0014 17.0 9.5 0.89 7.8 0.1 6.0 8 0 0 8 8 8 2 Adaptin N terminal region Mo25 PF08569.6 KOO34062.1 - 0.18 10.7 0.5 0.74 8.7 0.1 2.3 3 0 0 3 3 3 0 Mo25-like Cylicin_N PF15241.1 KOO34062.1 - 2.1 8.2 1.5 4.3 7.2 1.0 1.4 1 0 0 1 1 1 0 Cylicin N-terminus DUF2811 PF10929.3 KOO34063.1 - 0.056 13.4 0.0 7.8 6.5 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2811) KIAA1430 PF13879.1 KOO34065.1 - 0.92 9.9 5.1 11 6.4 3.5 2.1 1 1 0 1 1 1 0 KIAA1430 homologue Ax_dynein_light PF10211.4 KOO34065.1 - 4.8 6.9 11.9 6.6 6.5 5.5 2.2 1 1 1 2 2 2 0 Axonemal dynein light chain bZIP_2 PF07716.10 KOO34065.1 - 9.4 6.1 12.1 1.8 8.4 0.0 3.3 3 0 0 3 3 3 0 Basic region leucine zipper Ank_2 PF12796.2 KOO34066.1 - 1.3e-08 35.0 0.0 0.064 13.6 0.0 3.8 3 1 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO34066.1 - 0.00079 19.8 0.6 9.6 6.8 0.0 4.9 4 2 2 6 6 6 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO34066.1 - 0.0021 18.1 0.2 12 6.5 0.0 5.8 6 1 1 7 7 7 1 Ankyrin repeat Ank_5 PF13857.1 KOO34066.1 - 0.0054 16.9 0.1 16 5.9 0.0 4.2 5 1 1 6 6 6 1 Ankyrin repeats (many copies) Pico_P2B PF01552.12 KOO34066.1 - 0.08 13.1 0.0 0.45 10.6 0.0 2.1 2 0 0 2 2 2 0 Picornavirus 2B protein Filament PF00038.16 KOO34067.1 - 0.00048 19.7 22.6 0.006 16.0 2.0 2.2 1 1 1 2 2 2 2 Intermediate filament protein IncA PF04156.9 KOO34067.1 - 0.0052 16.3 12.9 0.0052 16.3 9.0 2.1 2 0 0 2 2 2 1 IncA protein AAA_13 PF13166.1 KOO34067.1 - 0.0091 14.5 13.6 0.012 14.1 9.5 1.0 1 0 0 1 1 1 1 AAA domain DUF2716 PF10898.3 KOO34067.1 - 0.059 13.3 0.7 0.1 12.6 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2716) YbhQ PF11076.3 KOO34067.1 - 0.095 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Putative inner membrane protein YbhQ Vps53_N PF04100.7 KOO34067.1 - 0.15 10.8 14.1 0.1 11.3 1.3 2.2 2 0 0 2 2 2 0 Vps53-like, N-terminal DUF3584 PF12128.3 KOO34067.1 - 0.18 9.1 23.3 0.23 8.7 16.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Paramyxo_P PF01806.12 KOO34067.1 - 0.23 10.6 6.4 1.4 8.1 3.9 2.0 1 1 1 2 2 2 0 Paramyxovirinae P phosphoprotein C-terminal region PRTP PF01366.13 KOO34067.1 - 0.26 9.2 9.7 0.44 8.4 2.8 2.0 2 0 0 2 2 2 0 Herpesvirus processing and transport protein Fe-S_assembly PF04384.8 KOO34067.1 - 0.37 11.1 4.5 1.4 9.3 1.6 2.2 1 1 1 2 2 2 0 Iron-sulphur cluster assembly ApoO PF09769.4 KOO34067.1 - 0.38 10.4 5.5 0.096 12.3 1.4 1.7 2 0 0 2 2 2 0 Apolipoprotein O Fib_alpha PF08702.5 KOO34067.1 - 0.51 10.4 12.6 7.7 6.6 6.0 2.5 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Myosin_tail_1 PF01576.14 KOO34067.1 - 0.59 7.7 29.6 0.37 8.4 8.7 2.2 2 0 0 2 2 2 0 Myosin tail DUF948 PF06103.6 KOO34067.1 - 0.79 9.6 8.7 1.1 9.1 0.6 2.7 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) PMC2NT PF08066.7 KOO34067.1 - 0.94 9.8 5.7 0.63 10.3 1.1 2.3 1 1 1 2 2 2 0 PMC2NT (NUC016) domain OmpH PF03938.9 KOO34067.1 - 1.1 9.1 27.1 0.37 10.7 4.0 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF4047 PF13256.1 KOO34067.1 - 2.5 8.0 12.3 0.057 13.3 1.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4047) Mnd1 PF03962.10 KOO34067.1 - 3.6 7.2 21.1 5.5 6.6 7.8 2.3 2 0 0 2 2 2 0 Mnd1 family DUF3391 PF11871.3 KOO34067.1 - 5.3 7.2 19.5 0.93 9.7 6.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) IFT57 PF10498.4 KOO34067.1 - 10 4.7 15.6 3.9 6.1 7.3 2.0 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Glutaredoxin2_C PF04399.8 KOO34071.1 - 1.6e-25 89.2 0.0 9.2e-18 64.1 0.0 2.1 2 0 0 2 2 2 2 Glutaredoxin 2, C terminal domain EF-hand_1 PF00036.27 KOO34072.1 - 2.6e-09 35.7 0.0 0.0007 18.7 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO34072.1 - 6.5e-09 34.9 0.1 0.0014 18.3 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO34072.1 - 2.8e-08 33.7 0.0 7.4e-08 32.4 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO34072.1 - 8.9e-05 21.6 0.1 0.38 10.1 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO34072.1 - 0.00027 20.4 0.0 0.0079 15.7 0.0 2.5 1 1 1 2 2 2 2 EF-hand domain pair HTH_31 PF13560.1 KOO34073.1 - 0.00081 19.5 0.1 0.00081 19.5 0.1 2.1 2 1 1 3 3 3 1 Helix-turn-helix domain MFS_1 PF07690.11 KOO34074.1 - 1.3e-31 109.5 50.5 1.8e-21 76.2 19.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 KOO34074.1 - 1.2e-11 43.6 28.4 4.7e-11 41.7 19.9 1.8 1 1 0 1 1 1 1 MFS/sugar transport protein MFS_3 PF05977.8 KOO34074.1 - 2e-06 26.2 10.1 2e-06 26.2 7.0 2.0 1 1 1 2 2 2 2 Transmembrane secretion effector Abhydrolase_6 PF12697.2 KOO34076.1 - 2.2e-18 66.9 4.5 2.2e-18 66.9 3.1 2.1 2 1 1 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO34076.1 - 8.2e-07 28.8 0.0 2.5e-05 24.0 0.0 2.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 KOO34076.1 - 5.4e-05 22.8 0.0 0.00013 21.6 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.15 KOO34076.1 - 0.0016 18.0 0.0 1 8.8 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold DAGAT PF03982.8 KOO34076.1 - 0.0018 17.0 0.0 0.0026 16.5 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol acyltransferase UPF0227 PF05728.7 KOO34076.1 - 0.03 14.0 0.0 0.074 12.7 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Acyltransferase PF01553.16 KOO34076.1 - 0.036 13.4 0.0 5 6.5 0.0 2.4 2 0 0 2 2 2 0 Acyltransferase Guanylate_kin PF00625.16 KOO34077.1 - 0.17 11.2 1.0 0.28 10.6 0.7 1.2 1 0 0 1 1 1 0 Guanylate kinase TAF4 PF05236.9 KOO34077.1 - 0.31 10.2 5.8 0.51 9.5 4.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Ceramidase PF05875.7 KOO34078.1 - 3.7e-29 101.6 8.6 4.9e-29 101.2 6.0 1.1 1 0 0 1 1 1 1 Ceramidase DPM3 PF08285.6 KOO34078.1 - 0.28 11.0 0.1 0.28 11.0 0.0 2.3 3 0 0 3 3 3 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) LURAP PF14854.1 KOO34079.1 - 0.016 14.9 2.5 2.2 8.0 0.1 2.8 1 1 1 2 2 2 0 Leucine rich adaptor protein Alginate_lyase PF05426.7 KOO34079.1 - 0.027 13.8 0.3 0.027 13.8 0.2 1.7 2 0 0 2 2 2 0 Alginate lyase DUF3972 PF13118.1 KOO34079.1 - 0.029 14.4 0.3 0.07 13.2 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3972) DUF1205 PF06722.7 KOO34079.1 - 0.18 12.0 2.3 0.27 11.5 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1205) Pkinase PF00069.20 KOO34080.1 - 2.4e-61 207.1 0.0 2.8e-61 206.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34080.1 - 3e-30 105.1 0.0 3.8e-30 104.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO34080.1 - 2.6e-05 24.0 0.5 0.011 15.5 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 KOO34080.1 - 0.00014 20.9 0.0 0.00028 20.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 KOO34080.1 - 0.00017 20.6 0.0 0.0012 17.8 0.0 2.0 1 1 1 2 2 2 1 Kinase-like Pantoate_transf PF02548.10 KOO34081.1 - 3.3e-105 350.9 0.1 6e-105 350.0 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase Pantoate_ligase PF02569.10 KOO34081.1 - 2.8e-84 282.2 0.0 3.9e-84 281.7 0.0 1.2 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase PEP_mutase PF13714.1 KOO34081.1 - 5e-09 35.7 0.4 5e-09 35.7 0.2 1.8 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase AIRS PF00586.19 KOO34081.1 - 1.1 9.5 8.0 0.48 10.7 0.5 3.3 3 0 0 3 3 3 0 AIR synthase related protein, N-terminal domain HI0933_like PF03486.9 KOO34082.1 - 2.4e-84 283.1 0.0 1.1e-46 159.1 0.0 2.0 1 1 1 2 2 2 2 HI0933-like protein DAO PF01266.19 KOO34082.1 - 2.6e-06 26.5 3.4 0.01 14.7 0.3 2.5 1 1 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 KOO34082.1 - 6e-06 25.3 2.8 1.3e-05 24.2 0.5 2.3 2 1 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.2 KOO34082.1 - 8.5e-05 21.8 0.4 0.00011 21.4 0.3 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.17 KOO34082.1 - 0.00022 20.2 1.1 0.32 9.8 0.0 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox PF00070.22 KOO34082.1 - 0.00025 21.3 0.2 0.31 11.4 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.16 KOO34082.1 - 0.0019 17.7 0.1 0.0042 16.6 0.0 1.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_2 PF07992.9 KOO34082.1 - 0.0025 17.7 0.1 0.0045 16.8 0.1 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 KOO34082.1 - 0.0026 16.7 0.2 0.004 16.1 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein HSP70 PF00012.15 KOO34083.1 - 5.9e-63 212.7 0.1 9.8e-52 175.6 0.0 2.9 2 1 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 KOO34083.1 - 1.6e-15 56.5 1.6 6.1e-15 54.6 0.3 2.4 2 1 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.11 KOO34083.1 - 0.0067 16.0 3.4 0.027 14.0 2.3 2.0 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.13 KOO34083.1 - 0.0077 15.3 8.2 0.45 9.5 0.0 3.0 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase StbA PF06406.6 KOO34083.1 - 0.099 11.5 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 StbA protein DUF1917 PF08939.5 KOO34084.1 - 0.099 12.3 0.1 0.15 11.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1917) MRI PF15325.1 KOO34084.1 - 4.2 8.3 5.5 1 10.3 0.2 2.6 3 1 0 3 3 3 0 Modulator of retrovirus infection EF-hand_7 PF13499.1 KOO34086.1 - 2.6e-23 81.9 2.5 3.2e-12 46.3 0.3 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO34086.1 - 6.2e-21 72.0 8.0 1.1e-06 27.4 0.8 4.8 4 1 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO34086.1 - 8.9e-19 65.6 2.6 0.00019 21.0 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 KOO34086.1 - 1.8e-16 59.4 8.1 1.2e-06 28.0 0.4 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO34086.1 - 1.3e-09 36.9 8.5 0.00078 18.6 0.2 4.3 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.1 KOO34086.1 - 9.9e-06 25.3 0.0 0.012 15.5 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain Caleosin PF05042.8 KOO34086.1 - 0.02 14.4 0.0 0.075 12.5 0.0 2.0 1 1 0 1 1 1 0 Caleosin related protein SPARC_Ca_bdg PF10591.4 KOO34086.1 - 0.028 14.4 0.5 0.13 12.2 0.4 1.8 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF2789 PF10982.3 KOO34086.1 - 0.1 12.6 0.3 18 5.4 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2789) Tenui_NCP PF04876.7 KOO34086.1 - 0.11 12.0 0.1 1.2 8.6 0.0 2.1 1 1 1 2 2 2 0 Tenuivirus major non-capsid protein DUF2004 PF09406.5 KOO34086.1 - 0.12 12.4 1.4 0.18 11.8 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2004) RNase_H_2 PF13482.1 KOO34086.1 - 0.12 12.1 0.1 0.86 9.3 0.0 2.0 1 1 1 2 2 2 0 RNase_H superfamily DUF179 PF02622.10 KOO34087.1 - 3.4e-10 39.7 0.0 1.6e-09 37.5 0.0 1.9 1 1 0 1 1 1 1 Uncharacterized ACR, COG1678 Nucleotid_trans PF03407.11 KOO34088.1 - 2.3e-40 138.6 0.0 3.5e-40 138.0 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase ATP-synt_ab PF00006.20 KOO34089.1 - 1e-105 351.9 0.0 1.6e-105 351.3 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 KOO34089.1 - 6e-22 78.2 0.1 1.1e-21 77.4 0.1 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 KOO34089.1 - 1e-16 60.8 0.8 6.8e-16 58.2 0.7 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain AAA_14 PF13173.1 KOO34089.1 - 0.024 14.5 0.0 0.056 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Peptidase_M23 PF01551.17 KOO34089.1 - 0.098 12.7 0.1 5.5 7.1 0.1 3.1 3 0 0 3 3 3 0 Peptidase family M23 Lsr2 PF11774.3 KOO34090.1 - 0.28 11.1 5.8 1.2 9.0 3.9 2.1 1 1 0 1 1 1 0 Lsr2 Neur_chan_memb PF02932.11 KOO34090.1 - 0.89 9.3 2.2 1.3 8.8 1.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Glutaredoxin PF00462.19 KOO34091.1 - 5e-15 55.2 0.0 7e-15 54.7 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin PAD_porph PF04371.10 KOO34091.1 - 0.032 13.2 0.0 0.037 13.0 0.0 1.1 1 0 0 1 1 1 0 Porphyromonas-type peptidyl-arginine deiminase EF-hand_1 PF00036.27 KOO34093.1 - 2.8e-19 66.8 4.2 2.3e-05 23.3 0.1 5.3 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.1 KOO34093.1 - 3.7e-17 60.6 7.7 2e-05 24.1 0.1 5.4 5 0 0 5 5 5 4 EF-hand domain EF-hand_7 PF13499.1 KOO34093.1 - 1.9e-15 56.7 6.3 1.3e-07 31.6 0.5 4.6 3 2 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO34093.1 - 1.7e-11 42.9 9.4 0.0041 16.3 0.0 4.9 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.1 KOO34093.1 - 8.3e-10 38.1 4.2 0.00024 20.6 0.1 3.9 3 1 0 3 3 3 3 EF-hand domain pair AcetDehyd-dimer PF09290.6 KOO34093.1 - 0.017 15.0 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic acetaldehyde dehydrogenase, dimerisation EF-hand_9 PF14658.1 KOO34093.1 - 0.044 13.7 0.0 6.5 6.7 0.0 3.5 3 1 1 4 4 4 0 EF-hand domain Aa_trans PF01490.13 KOO34096.1 - 7.4e-20 70.8 8.6 4.6e-19 68.1 6.0 1.8 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Aa_trans PF01490.13 KOO34097.1 - 5.1e-26 91.1 17.9 3.7e-25 88.2 12.4 2.0 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Aa_trans PF01490.13 KOO34098.1 - 0.0014 17.2 1.3 0.0015 17.1 0.9 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Myosin_head PF00063.16 KOO34099.1 - 9.7e-154 513.0 0.0 1.7e-84 284.1 0.0 2.8 1 1 2 3 3 3 2 Myosin head (motor domain) AAA_22 PF13401.1 KOO34099.1 - 0.0046 17.1 0.0 0.06 13.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KOO34099.1 - 0.023 14.6 0.0 0.023 14.6 0.0 3.1 3 1 0 3 3 3 0 AAA ATPase domain P19Arf_N PF07392.7 KOO34099.1 - 0.056 13.6 0.9 0.18 12.0 0.6 1.9 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus Seryl_tRNA_N PF02403.17 KOO34099.1 - 9.3 6.3 9.1 23 5.0 6.3 1.6 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Pkinase PF00069.20 KOO34100.1 - 5.6e-51 173.1 0.0 9.2e-51 172.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34100.1 - 1.8e-46 158.2 0.0 2.6e-46 157.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO34100.1 - 0.015 14.3 0.0 0.029 13.3 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Serglycin PF04360.7 KOO34100.1 - 0.024 14.3 1.5 0.05 13.3 0.6 1.8 2 0 0 2 2 2 0 Serglycin APH PF01636.18 KOO34100.1 - 0.17 11.5 0.1 0.3 10.7 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family FKBP_C PF00254.23 KOO34101.1 - 7.2e-14 51.5 0.0 1.3e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_5 PF13202.1 KOO34101.1 - 3.6e-07 29.2 3.3 0.0013 17.9 0.2 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO34101.1 - 6.2e-07 29.4 0.4 1.7e-06 28.0 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO34101.1 - 1.5e-06 27.0 3.6 0.019 14.2 0.1 2.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO34101.1 - 0.00013 21.5 0.5 0.092 12.3 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO34101.1 - 0.00028 20.4 4.7 0.23 11.4 0.1 3.1 3 0 0 3 3 3 2 EF-hand domain Helicase_C PF00271.26 KOO34103.1 - 3.1e-25 87.8 0.1 3.1e-25 87.8 0.1 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOO34103.1 - 2.2e-13 50.0 0.0 1.3e-12 47.5 0.0 2.1 3 0 0 3 3 3 1 DEAD/DEAH box helicase DUF1253 PF06862.7 KOO34103.1 - 0.013 13.9 0.0 0.44 8.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1253) CMS1 PF14617.1 KOO34103.1 - 0.09 11.8 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Helicase_C_2 PF13307.1 KOO34103.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Helicase C-terminal domain Aminotran_3 PF00202.16 KOO34104.1 - 1.7e-19 69.8 0.1 2.5e-19 69.3 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class-III zf-Apc11 PF12861.2 KOO34105.1 - 2.5e-29 100.9 8.4 3.2e-29 100.6 5.8 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 KOO34105.1 - 4.2e-28 97.2 7.0 5.5e-28 96.8 4.9 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 KOO34105.1 - 2.1e-12 46.6 6.5 3.9e-12 45.8 4.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 KOO34105.1 - 3.4e-06 26.6 3.8 3.4e-06 26.6 2.7 1.8 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 KOO34105.1 - 9.8e-06 25.1 5.8 1.8e-05 24.3 3.1 1.9 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO34105.1 - 1.6e-05 24.4 1.7 1.6e-05 24.4 1.2 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-P11 PF03854.9 KOO34105.1 - 0.00026 20.3 6.3 0.0061 16.0 1.4 2.2 2 0 0 2 2 2 2 P-11 zinc finger zf-C3HC4_2 PF13923.1 KOO34105.1 - 0.0005 20.0 7.8 0.0005 20.0 5.4 2.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.3 KOO34105.1 - 0.013 15.0 0.9 0.028 13.9 0.6 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.1 KOO34105.1 - 0.026 14.0 1.9 0.026 14.0 1.3 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 RecR PF02132.10 KOO34105.1 - 0.031 13.6 1.1 1.8 8.0 0.1 2.3 2 0 0 2 2 2 0 RecR protein zf-RING_6 PF14835.1 KOO34105.1 - 0.058 13.1 0.8 0.12 12.2 0.1 1.8 2 0 0 2 2 2 0 zf-RING of BARD1-type protein RINGv PF12906.2 KOO34105.1 - 0.074 13.1 5.1 0.074 13.1 3.5 2.3 2 0 0 2 2 2 0 RING-variant domain zf-RING_4 PF14570.1 KOO34105.1 - 0.16 11.6 6.6 0.066 12.8 1.1 2.1 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Viral_P18 PF04521.8 KOO34105.1 - 0.23 10.9 0.6 0.32 10.4 0.4 1.1 1 0 0 1 1 1 0 ssRNA positive strand viral 18kD cysteine rich protein Molybdop_Fe4S4 PF04879.11 KOO34105.1 - 1.7 8.4 4.7 1 9.2 0.1 2.4 2 1 0 2 2 2 0 Molybdopterin oxidoreductase Fe4S4 domain Nucleotid_trans PF03407.11 KOO34106.1 - 3.8e-18 66.0 0.0 1.4e-17 64.2 0.0 1.8 2 0 0 2 2 2 1 Nucleotide-diphospho-sugar transferase Glyco_transf_8 PF01501.15 KOO34106.1 - 0.0081 15.5 0.0 0.019 14.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 8 Ank_2 PF12796.2 KOO34107.1 - 2.7e-21 75.7 0.0 1.2e-09 38.4 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO34107.1 - 2.9e-19 67.8 2.5 6.6e-06 25.6 0.0 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.1 KOO34107.1 - 9.3e-15 54.6 0.2 7.9e-10 38.9 0.0 4.0 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO34107.1 - 1.8e-11 43.0 3.6 0.0011 19.0 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.1 KOO34107.1 - 1.4e-09 37.8 2.9 0.0013 18.8 0.0 4.2 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Shadoo PF14999.1 KOO34108.1 - 0.029 14.2 2.1 0.048 13.5 1.5 1.4 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective Gly_transf_sug PF04488.10 KOO34109.1 - 4.4e-05 23.8 0.0 0.0001 22.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.7 KOO34109.1 - 0.00021 20.5 0.0 0.00028 20.1 0.0 1.2 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein TcdA_TcdB PF12919.2 KOO34109.1 - 0.0052 15.3 0.0 0.0075 14.7 0.0 1.2 1 0 0 1 1 1 1 TcdA/TcdB catalytic glycosyltransferase domain IPPT PF01715.12 KOO34112.1 - 2.1e-60 203.8 0.0 4.6e-60 202.7 0.0 1.5 2 0 0 2 2 2 1 IPP transferase LVIVD PF08309.6 KOO34113.1 - 3.2e-53 176.4 56.0 4.6e-11 41.5 1.4 6.3 6 0 0 6 6 6 6 LVIVD repeat Laminin_G_3 PF13385.1 KOO34113.1 - 5.3e-10 39.7 0.0 1e-09 38.8 0.0 1.6 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily PSCyt3 PF07627.6 KOO34113.1 - 2.5e-07 30.4 0.1 7.2 6.5 0.0 5.2 2 1 3 5 5 5 4 Protein of unknown function (DUF1588) Beta_propel PF09826.4 KOO34113.1 - 3e-05 22.5 0.2 8.6 4.5 0.0 4.6 4 1 0 4 4 4 4 Beta propeller domain SBP56 PF05694.6 KOO34113.1 - 0.0028 16.2 0.5 0.64 8.4 0.0 3.3 1 1 1 3 3 3 2 56kDa selenium binding protein (SBP56) Herpes_BLLF1 PF05109.8 KOO34114.1 - 4.8 5.0 8.1 4.9 4.9 5.6 1.0 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) Myb_DNA-bind_6 PF13921.1 KOO34117.1 - 4.2e-06 26.7 0.9 2.8e-05 24.1 0.3 2.4 2 1 1 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 KOO34117.1 - 0.0022 18.0 1.0 0.2 11.7 0.1 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain VWA_2 PF13519.1 KOO34118.1 - 0.00017 21.7 0.5 0.00048 20.2 0.0 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain RNA_polI_A14 PF08203.6 KOO34118.1 - 0.045 13.9 0.7 3.6 7.9 0.0 3.0 2 0 0 2 2 2 0 Yeast RNA polymerase I subunit RPA14 PX PF00787.19 KOO34119.1 - 1.4e-12 47.4 0.2 2.5e-12 46.5 0.1 1.4 1 0 0 1 1 1 1 PX domain RUN PF02759.14 KOO34119.1 - 3.9e-12 46.0 0.1 9.7e-12 44.7 0.0 1.7 1 0 0 1 1 1 1 RUN domain CtaG_Cox11 PF04442.9 KOO34120.1 - 4.5e-58 195.3 0.0 5.3e-58 195.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 FHA PF00498.21 KOO34123.1 - 1e-11 44.7 0.0 1.6e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 FHA domain EF-hand_1 PF00036.27 KOO34126.1 - 1.2e-07 30.5 0.2 1.2e-07 30.5 0.2 1.8 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.1 KOO34126.1 - 2e-06 26.8 0.2 2e-06 26.8 0.1 1.9 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO34126.1 - 4.9e-05 22.8 0.2 4.9e-05 22.8 0.1 1.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.1 KOO34126.1 - 0.00018 21.0 0.1 0.00018 21.0 0.1 1.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.1 KOO34126.1 - 0.00043 20.3 1.3 0.00044 20.3 0.9 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO34127.1 - 9.9e-19 65.1 4.2 9.4e-06 24.5 0.1 4.3 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.1 KOO34127.1 - 6.4e-17 61.4 1.7 2.7e-10 40.2 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO34127.1 - 2.2e-15 55.0 0.0 0.0074 16.0 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain PDZ PF00595.19 KOO34127.1 - 1.3e-14 54.0 0.2 3.7e-06 27.0 0.0 3.3 3 0 0 3 3 3 2 PDZ domain (Also known as DHR or GLGF) EF-hand_5 PF13202.1 KOO34127.1 - 3.3e-14 51.4 2.3 0.0015 17.7 0.1 4.0 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO34127.1 - 6.3e-11 41.7 6.7 1.2e-06 28.0 0.3 3.6 3 1 1 4 4 4 2 EF-hand domain pair PDZ_2 PF13180.1 KOO34127.1 - 3.4e-07 30.0 0.0 0.0018 18.1 0.0 2.7 2 0 0 2 2 2 2 PDZ domain SPARC_Ca_bdg PF10591.4 KOO34127.1 - 7.6e-07 29.1 0.0 0.033 14.2 0.0 2.4 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO34127.1 - 3.1e-05 23.6 0.2 0.21 11.3 0.1 2.7 2 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO34127.1 - 0.0094 15.8 0.0 0.3 11.0 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain Tricorn_PDZ PF14685.1 KOO34127.1 - 0.027 14.2 0.0 0.1 12.4 0.0 2.0 1 0 0 1 1 1 0 Tricorn protease PDZ domain Bac_DNA_binding PF00216.16 KOO34128.1 - 7.2e-29 99.6 0.3 8.2e-29 99.4 0.2 1.0 1 0 0 1 1 1 1 Bacterial DNA-binding protein DUF4496 PF14908.1 KOO34128.1 - 0.0032 17.3 0.2 0.0062 16.4 0.1 1.5 1 1 1 2 2 2 1 Domain of unknown function (DUF4496) LacI PF00356.16 KOO34128.1 - 0.056 13.0 1.0 0.11 12.1 0.7 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family HU-DNA_bdg PF14848.1 KOO34128.1 - 0.068 12.8 0.0 0.16 11.6 0.0 1.5 2 0 0 2 2 2 0 DNA-binding domain S1-like PF14444.1 KOO34128.1 - 0.13 11.9 0.1 3.8 7.3 0.0 2.4 2 0 0 2 2 2 0 S1-like Reo_sigmaC PF04582.7 KOO34129.1 - 0.22 10.6 3.6 0.26 10.3 2.1 1.4 1 1 0 1 1 1 0 Reovirus sigma C capsid protein Vfa1 PF08432.5 KOO34129.1 - 4.2 7.3 16.5 7.3 6.5 11.4 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Herpes_env PF01673.13 KOO34129.1 - 4.4 5.7 14.5 6.4 5.2 10.1 1.2 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein Totivirus_coat PF05518.6 KOO34130.1 - 4.9 4.8 6.2 6 4.5 4.3 1.1 1 0 0 1 1 1 0 Totivirus coat protein SPRY PF00622.23 KOO34131.1 - 0.00034 20.6 0.0 0.44 10.6 0.0 2.7 2 0 0 2 2 2 2 SPRY domain LRR_4 PF12799.2 KOO34131.1 - 0.032 13.8 0.0 73 3.1 0.0 3.6 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) 60KD_IMP PF02096.15 KOO34133.1 - 1.8e-58 197.4 0.3 2.3e-58 197.1 0.2 1.1 1 0 0 1 1 1 1 60Kd inner membrane protein DUF3321 PF11968.3 KOO34134.1 - 2.2e-07 30.7 0.0 0.00064 19.4 0.0 2.2 2 0 0 2 2 2 2 Putative methyltransferase (DUF3321) Methyltransf_12 PF08242.7 KOO34134.1 - 0.043 14.2 0.0 0.084 13.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 KOO34134.1 - 0.086 13.3 0.0 0.28 11.6 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain TMA7 PF09072.5 KOO34135.1 - 0.0066 16.8 3.5 0.013 15.9 2.5 1.5 1 0 0 1 1 1 1 Translation machinery associated TMA7 LRR_6 PF13516.1 KOO34136.1 - 2.1e-18 64.2 7.7 0.021 14.8 0.3 8.0 8 0 0 8 8 8 6 Leucine Rich repeat LRR_1 PF00560.28 KOO34136.1 - 1.6e-06 27.3 0.1 3.1 8.1 0.1 5.6 7 0 0 7 7 7 2 Leucine Rich Repeat LRR_4 PF12799.2 KOO34136.1 - 3.3e-05 23.4 4.0 0.059 13.0 1.2 3.7 3 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO34136.1 - 0.0017 18.0 4.9 4.8 7.0 2.2 4.4 3 2 0 3 3 3 1 Leucine rich repeat LRR_7 PF13504.1 KOO34136.1 - 0.014 15.4 3.8 21 5.8 0.1 5.3 7 0 0 7 7 7 0 Leucine rich repeat DUF3506 PF12014.3 KOO34138.1 - 0.00011 21.9 0.0 0.00019 21.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3506) LRR_4 PF12799.2 KOO34141.1 - 3.4e-07 29.7 0.2 8.9e-05 22.0 0.0 3.6 5 0 0 5 5 5 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO34141.1 - 0.00026 20.6 1.9 0.29 11.3 0.0 5.0 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_6 PF13516.1 KOO34141.1 - 0.0013 18.5 2.7 0.77 10.0 0.0 4.9 6 0 0 6 6 6 1 Leucine Rich repeat LRR_8 PF13855.1 KOO34141.1 - 0.0061 16.2 1.6 0.34 10.6 0.0 4.1 5 0 0 5 5 5 1 Leucine rich repeat LRR_7 PF13504.1 KOO34141.1 - 0.035 14.2 8.7 3.3 8.3 0.0 6.1 7 1 0 7 7 7 0 Leucine rich repeat O-FucT PF10250.4 KOO34143.1 - 1.8e-05 24.0 0.0 4.7e-05 22.6 0.0 1.5 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase TMEM18 PF14770.1 KOO34144.1 - 2.2e-44 149.9 0.9 2.7e-44 149.6 0.7 1.1 1 0 0 1 1 1 1 Transmembrane protein 18 HCV_env PF01539.12 KOO34144.1 - 0.057 12.8 0.5 0.069 12.6 0.3 1.1 1 0 0 1 1 1 0 Hepatitis C virus envelope glycoprotein E1 DAGK_prokar PF01219.14 KOO34144.1 - 0.12 11.9 0.3 0.12 11.9 0.2 1.7 2 0 0 2 2 2 0 Prokaryotic diacylglycerol kinase DUF1202 PF06717.6 KOO34145.1 - 0.21 10.8 7.9 0.25 10.5 5.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1202) CAF-1_p150 PF11600.3 KOO34145.1 - 0.48 9.7 27.9 0.8 9.0 19.4 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal EURL PF06937.6 KOO34145.1 - 8.4 5.7 15.1 19 4.5 10.5 1.6 1 1 0 1 1 1 0 EURL protein TMCO5 PF14992.1 KOO34145.1 - 8.5 5.4 13.8 11 5.0 9.6 1.1 1 0 0 1 1 1 0 TMCO5 family DUF1423 PF07227.6 KOO34145.1 - 9.7 4.7 19.6 12 4.3 13.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1423) FAD_binding_3 PF01494.14 KOO34146.1 - 5.7e-08 32.1 1.5 5.4e-07 28.9 1.0 2.4 1 1 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 KOO34146.1 - 0.00011 20.7 0.0 0.00017 20.1 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.1 KOO34146.1 - 0.0002 21.3 0.0 0.0004 20.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOO34146.1 - 0.00022 20.2 0.1 0.00041 19.3 0.1 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 KOO34146.1 - 0.0025 17.7 0.0 0.0038 17.1 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOO34146.1 - 0.0029 17.6 0.0 0.0044 17.0 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 KOO34146.1 - 0.017 14.0 0.0 0.032 13.1 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_2 PF00890.19 KOO34146.1 - 0.041 12.7 0.0 0.064 12.0 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.1 KOO34146.1 - 0.043 13.5 0.3 0.12 12.1 0.2 1.9 1 1 0 1 1 1 0 FAD-NAD(P)-binding Na_Ca_ex PF01699.19 KOO34148.1 - 5.8e-42 142.6 23.0 2.1e-23 82.4 5.5 2.6 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Calx-beta PF03160.9 KOO34148.1 - 9.9e-21 73.5 0.1 8.5e-18 64.1 0.2 2.7 3 0 0 3 3 3 2 Calx-beta domain UCR_hinge PF02320.11 KOO34148.1 - 7.2e-09 35.4 0.4 1.7e-08 34.2 0.3 1.6 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein WD40 PF00400.27 KOO34149.1 - 0.0093 15.8 0.1 0.034 14.0 0.0 1.8 2 0 0 2 2 2 1 WD domain, G-beta repeat DUF3070 PF11270.3 KOO34149.1 - 1.7 8.4 5.4 3.9 7.3 3.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3070) KAT11 PF08214.6 KOO34151.1 - 1.5e-36 126.2 0.6 8.9e-36 123.6 0.1 2.1 1 1 1 2 2 2 1 Histone acetylation protein PHD PF00628.24 KOO34151.1 - 0.00065 19.3 7.8 0.00065 19.3 5.4 2.7 2 0 0 2 2 2 1 PHD-finger Cytochrome_C554 PF13435.1 KOO34151.1 - 0.017 15.1 1.9 0.017 15.1 1.3 2.3 2 1 1 3 3 3 0 Cytochrome c554 and c-prime zf-SNAP50_C PF12251.3 KOO34151.1 - 4.5 6.6 9.3 0.19 11.1 0.4 2.7 3 0 0 3 3 3 0 snRNA-activating protein of 50kDa MW C terminal LRR_6 PF13516.1 KOO34152.1 - 4e-11 41.7 1.5 0.13 12.4 0.0 4.8 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.2 KOO34152.1 - 0.0016 18.0 0.0 0.011 15.4 0.0 2.2 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) AMP-binding PF00501.23 KOO34153.1 - 2.2e-59 200.9 0.2 3.2e-59 200.3 0.2 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.15 KOO34154.1 - 9.9e-32 109.9 0.0 2.2e-31 108.8 0.0 1.6 1 0 0 1 1 1 1 Condensation domain NRPS PF08415.5 KOO34154.1 - 4.8e-06 26.2 0.2 1.3e-05 24.8 0.2 1.8 1 0 0 1 1 1 1 Nonribosomal peptide synthase PP-binding PF00550.20 KOO34154.1 - 0.00053 20.1 0.0 0.75 10.0 0.0 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site Ribosomal_60s PF00428.14 KOO34155.1 - 1.9 8.9 4.6 11 6.5 0.6 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein PcF PF09461.5 KOO34156.1 - 0.013 15.3 0.3 0.05 13.5 0.0 2.0 2 0 0 2 2 2 0 Phytotoxin PcF protein zf-HYPF PF07503.7 KOO34157.1 - 0.38 10.2 6.6 1 8.7 0.7 2.5 2 0 0 2 2 2 0 HypF finger Lipase_GDSL_2 PF13472.1 KOO34159.1 - 1.1e-08 35.3 0.1 1.7e-08 34.8 0.1 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Ax_dynein_light PF10211.4 KOO34160.1 - 1.8e-35 122.5 0.4 2.8e-35 121.8 0.3 1.2 1 0 0 1 1 1 1 Axonemal dynein light chain PKD_channel PF08016.7 KOO34161.1 - 4.2e-48 163.8 26.8 2.3e-37 128.4 16.9 2.1 2 0 0 2 2 2 2 Polycystin cation channel Ion_trans PF00520.26 KOO34161.1 - 5.2e-07 29.1 28.6 1e-06 28.1 19.8 1.5 1 1 0 1 1 1 1 Ion transport protein HemY_N PF07219.8 KOO34161.1 - 0.22 11.0 2.4 1.1 8.8 0.0 2.7 2 0 0 2 2 2 0 HemY protein N-terminus FUN14 PF04930.10 KOO34162.1 - 2.5e-20 72.6 0.4 4.2e-20 71.8 0.3 1.4 1 0 0 1 1 1 1 FUN14 family EF-hand_1 PF00036.27 KOO34162.1 - 0.0074 15.5 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 EF hand Dockerin_1 PF00404.13 KOO34162.1 - 0.0082 15.8 0.2 0.017 14.8 0.1 1.5 1 0 0 1 1 1 1 Dockerin type I repeat EF-hand_6 PF13405.1 KOO34162.1 - 0.024 14.4 0.0 0.053 13.4 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain EF-hand_5 PF13202.1 KOO34162.1 - 0.03 13.6 0.0 0.052 12.9 0.0 1.3 1 0 0 1 1 1 0 EF hand Tim17 PF02466.14 KOO34163.1 - 2.2e-18 66.5 6.7 2.7e-18 66.2 4.6 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family NARP1 PF12569.3 KOO34166.1 - 2.4e-188 627.1 20.2 1.1e-187 624.8 11.7 2.2 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_11 PF13414.1 KOO34166.1 - 1.8e-12 46.6 26.7 0.00087 18.8 0.0 8.2 7 1 2 9 9 9 4 TPR repeat TPR_2 PF07719.12 KOO34166.1 - 3.4e-12 45.2 26.7 0.0017 18.1 0.1 9.3 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO34166.1 - 5.6e-11 42.8 47.9 0.00041 20.9 1.2 9.8 8 2 2 10 10 10 4 Tetratricopeptide repeat TPR_14 PF13428.1 KOO34166.1 - 9.4e-09 35.1 48.7 0.0017 18.8 0.6 10.5 11 2 2 13 13 10 4 Tetratricopeptide repeat TPR_12 PF13424.1 KOO34166.1 - 1.2e-08 34.7 25.0 0.21 11.5 0.2 7.5 6 2 2 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.23 KOO34166.1 - 9.8e-07 28.1 16.2 0.046 13.3 0.1 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_15 PF13429.1 KOO34166.1 - 6e-06 25.5 15.0 0.046 12.7 0.0 4.8 3 3 1 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOO34166.1 - 1.6e-05 25.1 32.1 0.2 12.0 0.8 9.2 7 3 2 9 9 9 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO34166.1 - 8.2e-05 22.5 6.7 2.2 8.7 0.0 8.1 10 0 0 10 10 8 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO34166.1 - 0.00015 21.2 11.1 0.13 12.0 0.0 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO34166.1 - 0.003 17.4 6.9 0.28 11.1 0.0 4.7 5 1 1 6 6 5 1 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.1 KOO34166.1 - 0.0037 16.9 5.3 4.5 7.2 0.0 5.8 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOO34166.1 - 0.012 15.4 26.4 0.55 10.1 0.3 7.1 6 2 1 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO34166.1 - 0.05 14.0 18.9 0.67 10.5 0.1 7.5 8 0 0 8 8 5 0 Tetratricopeptide repeat RNase_H2-Ydr279 PF09468.5 KOO34166.1 - 0.055 12.6 1.4 0.097 11.8 0.9 1.4 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) TPR_10 PF13374.1 KOO34166.1 - 0.061 13.2 9.5 0.2 11.6 0.2 5.2 4 0 0 4 4 4 0 Tetratricopeptide repeat EF-hand_1 PF00036.27 KOO34167.1 - 1.1e-26 90.0 6.0 1.1e-05 24.4 0.0 6.5 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.1 KOO34167.1 - 1.5e-21 76.2 3.4 1.4e-08 34.7 0.1 4.5 4 1 0 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO34167.1 - 3e-21 73.3 7.7 0.00061 19.4 0.0 6.9 7 0 0 7 7 7 5 EF-hand domain EF-hand_8 PF13833.1 KOO34167.1 - 1.3e-13 50.3 7.5 1.5e-05 24.5 0.1 5.8 5 1 1 6 6 6 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO34167.1 - 1.9e-12 45.9 10.9 0.00039 19.6 0.0 5.9 6 0 0 6 6 6 3 EF hand SPARC_Ca_bdg PF10591.4 KOO34167.1 - 0.0041 17.1 0.0 0.1 12.6 0.0 2.9 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO34167.1 - 0.027 14.1 0.6 5.5 6.7 0.1 3.6 2 1 2 4 4 4 0 Cytoskeletal-regulatory complex EF hand PAP_fibrillin PF04755.7 KOO34168.1 - 0.0033 17.1 0.0 0.0049 16.6 0.0 1.2 1 0 0 1 1 1 1 PAP_fibrillin E1_dh PF00676.15 KOO34169.1 - 7.7e-103 343.3 0.1 9.7e-103 342.9 0.1 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.1 KOO34169.1 - 9.5e-06 24.7 0.0 1.6e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.16 KOO34169.1 - 0.0012 18.4 0.6 0.0012 18.4 0.4 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CoaE PF01121.15 KOO34171.1 - 0.079 12.3 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Dephospho-CoA kinase EF-hand_6 PF13405.1 KOO34173.1 - 6.9e-35 115.7 16.4 1.3e-06 27.7 0.9 7.1 7 0 0 7 7 7 6 EF-hand domain EF-hand_1 PF00036.27 KOO34173.1 - 8.2e-35 115.4 17.3 1.2e-06 27.3 0.9 7.4 8 0 0 8 8 8 6 EF hand EF-hand_7 PF13499.1 KOO34173.1 - 2.7e-33 113.9 15.6 2.3e-10 40.4 0.1 4.6 2 1 3 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.1 KOO34173.1 - 1.9e-24 83.8 20.9 9.2e-07 27.9 1.7 7.6 7 0 0 7 7 7 6 EF hand EF-hand_8 PF13833.1 KOO34173.1 - 5.9e-22 77.0 10.6 0.00023 20.6 1.3 6.1 3 3 3 6 6 6 6 EF-hand domain pair EF-hand_9 PF14658.1 KOO34173.1 - 0.00036 20.3 0.3 4.7 7.2 0.0 4.8 4 1 0 5 5 5 1 EF-hand domain EF-hand_10 PF14788.1 KOO34173.1 - 0.018 14.7 5.5 15 5.3 0.0 5.4 6 1 1 7 7 7 0 EF hand SPARC_Ca_bdg PF10591.4 KOO34173.1 - 0.018 15.0 0.0 78 3.3 0.0 3.9 4 0 0 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region WD40 PF00400.27 KOO34175.1 - 7.6e-113 364.8 28.7 1.5e-12 46.8 0.3 9.2 9 0 0 9 9 9 9 WD domain, G-beta repeat PD40 PF07676.7 KOO34175.1 - 6e-19 67.2 14.4 0.42 10.3 0.0 9.2 9 0 0 9 9 9 8 WD40-like Beta Propeller Repeat BBS2_Mid PF14783.1 KOO34175.1 - 1.8e-11 43.7 0.4 0.035 13.8 0.0 5.8 2 2 4 6 6 6 5 Ciliary BBSome complex subunit 2, middle region DUF3312 PF11768.3 KOO34175.1 - 1.4e-09 36.7 0.0 0.014 13.6 0.0 4.0 2 2 2 4 4 4 3 Protein of unknown function (DUF3312) Nbas_N PF15492.1 KOO34175.1 - 3.4e-05 23.0 8.7 16 4.5 0.0 6.8 2 2 6 8 8 8 0 Neuroblastoma-amplified sequence, N terminal Nucleoporin_N PF08801.6 KOO34175.1 - 0.00011 21.1 10.1 0.47 9.1 0.7 4.8 2 2 1 3 3 3 3 Nup133 N terminal like IKI3 PF04762.7 KOO34175.1 - 0.00026 18.9 3.7 0.79 7.4 0.0 3.5 1 1 3 4 4 4 2 IKI3 family Dfp1_Him1_M PF08630.5 KOO34175.1 - 0.0018 18.0 9.3 7.8 6.3 0.0 6.4 8 0 0 8 8 8 2 Dfp1/Him1, central region UN_NPL4 PF11543.3 KOO34175.1 - 0.017 15.4 4.3 3.4e+02 1.6 0.0 7.1 8 1 0 8 8 8 0 Nuclear pore localisation protein NPL4 Cofilin_ADF PF00241.15 KOO34175.1 - 0.047 13.5 2.4 35 4.2 0.0 4.8 7 1 0 7 7 7 0 Cofilin/tropomyosin-type actin-binding protein Cep57_MT_bd PF06657.8 KOO34175.1 - 0.075 12.9 2.6 10 6.1 0.1 2.9 4 0 0 4 4 3 0 Centrosome microtubule-binding domain of Cep57 Mlf1IP PF10248.4 KOO34175.1 - 0.11 12.0 0.0 26 4.3 0.0 3.4 4 0 0 4 4 4 0 Myelodysplasia-myeloid leukemia factor 1-interacting protein SprB PF13573.1 KOO34175.1 - 6.9 6.3 6.7 3.8e+02 0.7 0.0 4.7 5 0 0 5 5 5 0 SprB repeat LRR_6 PF13516.1 KOO34176.1 - 2.1e-34 113.7 0.1 0.0007 19.4 0.1 8.7 8 0 0 8 8 8 7 Leucine Rich repeat LRR_4 PF12799.2 KOO34176.1 - 1.8e-11 43.3 0.0 0.0026 17.3 0.0 5.1 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO34176.1 - 3.4e-09 36.3 0.0 0.0042 16.7 0.0 4.9 4 2 0 4 4 4 2 Leucine rich repeat LRR_1 PF00560.28 KOO34176.1 - 2.7e-07 29.6 0.0 43 4.7 0.0 7.3 8 1 0 8 8 8 0 Leucine Rich Repeat LRR_7 PF13504.1 KOO34176.1 - 3.3e-07 29.4 3.4 75 4.2 0.0 7.8 8 0 0 8 8 7 0 Leucine rich repeat EF-hand_7 PF13499.1 KOO34176.1 - 6.8e-05 22.9 0.1 0.0002 21.4 0.0 1.9 2 0 0 2 2 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO34176.1 - 0.0054 15.9 0.0 0.014 14.6 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO34176.1 - 0.0087 15.8 0.0 0.03 14.1 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain V_ATPase_I PF01496.14 KOO34176.1 - 0.013 13.3 7.5 0.018 12.9 5.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Borrelia_P83 PF05262.6 KOO34176.1 - 0.022 13.0 20.1 0.041 12.1 13.9 1.4 1 0 0 1 1 1 0 Borrelia P83/100 protein zf-C4H2 PF10146.4 KOO34176.1 - 0.026 14.5 5.9 0.044 13.8 4.1 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein EF-hand_5 PF13202.1 KOO34176.1 - 0.03 13.6 0.1 0.1 11.9 0.0 1.9 1 0 0 1 1 1 0 EF hand RAP1 PF07218.6 KOO34176.1 - 0.11 10.5 1.6 0.15 10.1 1.1 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) NPV_P10 PF05531.7 KOO34176.1 - 1.9 8.7 6.4 3.9 7.7 0.1 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein HlyD_2 PF12700.2 KOO34176.1 - 4.9 6.2 7.0 6.6 5.7 4.8 1.2 1 0 0 1 1 1 0 HlyD family secretion protein EF-hand_5 PF13202.1 KOO34177.1 - 1.3e-09 36.9 0.4 0.0018 17.5 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO34177.1 - 1.9e-09 36.5 0.4 0.00048 19.7 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO34177.1 - 5.4e-09 34.7 0.5 0.0004 19.4 0.3 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO34177.1 - 1.7e-08 34.4 0.6 3.8e-08 33.3 0.2 1.8 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO34177.1 - 2.7e-06 26.8 5.7 0.0057 16.2 0.4 2.7 3 0 0 3 3 3 2 EF-hand domain pair Viral_DNA_Zn_bi PF03728.8 KOO34178.1 - 0.034 14.2 1.0 0.1 12.7 0.7 1.8 1 1 0 1 1 1 0 Viral DNA-binding protein, zinc binding domain EF-hand_1 PF00036.27 KOO34179.1 - 8.7e-15 52.8 12.7 2.1e-06 26.5 1.0 3.7 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.1 KOO34179.1 - 7.2e-14 51.6 4.3 5.9e-10 39.1 0.4 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO34179.1 - 6.4e-13 47.4 11.1 0.0015 18.2 0.1 3.7 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.1 KOO34179.1 - 1.7e-12 46.7 5.0 9.3e-09 34.7 0.3 2.9 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO34179.1 - 8e-08 31.2 11.5 0.017 14.4 0.2 3.7 3 0 0 3 3 3 3 EF hand EF-hand_4 PF12763.2 KOO34179.1 - 8.4e-05 22.2 0.0 0.00025 20.7 0.0 1.7 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_like PF09279.6 KOO34179.1 - 0.0019 18.2 0.3 0.1 12.6 0.1 2.7 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_10 PF14788.1 KOO34179.1 - 0.015 14.9 3.0 2.9 7.6 0.0 2.6 2 0 0 2 2 2 0 EF hand TIR_2 PF13676.1 KOO34180.1 - 1.9e-05 24.7 0.0 9.4e-05 22.5 0.0 2.1 2 0 0 2 2 2 1 TIR domain Na_H_Exchanger PF00999.16 KOO34181.1 - 3e-42 144.5 38.0 4.2e-42 144.0 26.4 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Peptidase_M17_N PF02789.12 KOO34181.1 - 0.42 10.3 6.2 0.44 10.3 0.6 2.7 2 1 0 2 2 2 0 Cytosol aminopeptidase family, N-terminal domain Methyltransf_4 PF02390.12 KOO34183.1 - 0.14 11.2 0.1 0.21 10.6 0.1 1.2 1 0 0 1 1 1 0 Putative methyltransferase tRNA_SAD PF07973.9 KOO34184.1 - 6.3e-10 38.7 0.7 1.1e-09 38.0 0.5 1.4 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.14 KOO34184.1 - 0.0066 14.7 0.0 0.0092 14.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) La PF05383.12 KOO34185.1 - 3.2e-16 58.8 0.0 6.8e-16 57.8 0.0 1.5 1 0 0 1 1 1 1 La domain DEAD PF00270.24 KOO34185.1 - 9.5e-15 54.4 0.0 2.4e-14 53.1 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase SPRY PF00622.23 KOO34185.1 - 6.5e-13 48.8 0.0 1.3e-12 47.8 0.0 1.5 1 0 0 1 1 1 1 SPRY domain EF-hand_1 PF00036.27 KOO34185.1 - 1.2e-07 30.5 0.0 0.001 18.1 0.0 3.0 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO34185.1 - 2e-07 30.3 0.4 1.7e-05 24.2 0.0 3.0 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.1 KOO34185.1 - 3e-07 30.4 0.0 8.6e-07 29.0 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO34185.1 - 9e-06 25.2 0.0 0.0077 15.8 0.0 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO34185.1 - 4e-05 22.7 0.0 0.13 11.6 0.0 2.7 2 0 0 2 2 2 2 EF hand SH3_3 PF08239.6 KOO34185.1 - 0.00016 21.7 0.0 0.73 10.0 0.0 3.4 3 0 0 3 3 3 2 Bacterial SH3 domain adh_short PF00106.20 KOO34187.1 - 4.6e-20 72.1 0.1 6.6e-20 71.6 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KOO34187.1 - 7.1e-10 39.0 0.0 9.6e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KOO34187.1 - 8e-07 28.8 0.0 1.2e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 KOO34187.1 - 0.0017 17.2 0.0 0.0022 16.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.3 KOO34187.1 - 0.0069 16.1 0.0 0.019 14.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_10 PF13460.1 KOO34187.1 - 0.015 15.2 0.2 0.048 13.6 0.1 1.8 2 0 0 2 2 2 0 NADH(P)-binding DUF1776 PF08643.5 KOO34187.1 - 0.021 13.9 0.0 0.053 12.6 0.0 1.6 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) Esterase PF00756.15 KOO34188.1 - 0.00078 18.9 0.0 0.0014 18.0 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.2 KOO34189.1 - 3.1e-09 37.0 3.8 3.6e-09 36.8 2.6 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO34189.1 - 1.5e-05 24.6 0.0 1.5e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ndr PF03096.9 KOO34189.1 - 2.3e-05 23.0 0.1 3.2e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Ndr family Abhydrolase_5 PF12695.2 KOO34189.1 - 0.00025 20.7 0.1 0.0012 18.6 0.1 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family OTU PF02338.14 KOO34190.1 - 1.9e-08 34.8 0.8 3.7e-05 24.2 0.0 3.0 3 0 0 3 3 3 2 OTU-like cysteine protease Peptidase_C65 PF10275.4 KOO34190.1 - 0.23 10.7 0.9 1.9 7.7 0.0 2.4 2 1 1 3 3 3 0 Peptidase C65 Otubain DUF4232 PF14016.1 KOO34191.1 - 0.11 12.1 4.2 0.65 9.6 1.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4232) E1-E2_ATPase PF00122.15 KOO34192.1 - 1.3e-53 181.3 3.0 3.5e-53 180.0 2.1 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 KOO34192.1 - 6.5e-25 88.8 0.0 2.6e-24 86.8 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO34192.1 - 6.6e-13 49.2 0.0 1.7e-12 47.8 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 KOO34192.1 - 2.1e-11 43.1 0.0 5.1e-11 41.8 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 KOO34192.1 - 0.00023 20.8 0.2 0.00092 18.8 0.1 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Chlorosome_CsmC PF11098.3 KOO34192.1 - 0.031 13.9 1.6 0.11 12.2 1.1 1.9 1 0 0 1 1 1 0 Chlorosome envelope protein C Hydrolase_like2 PF13246.1 KOO34192.1 - 0.14 12.1 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 Putative hydrolase of sodium-potassium ATPase alpha subunit Metallophos PF00149.23 KOO34193.1 - 0.00023 20.5 0.0 0.15 11.4 0.0 2.2 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase PhoD PF09423.5 KOO34193.1 - 0.055 12.0 0.0 0.07 11.6 0.0 1.2 1 0 0 1 1 1 0 PhoD-like phosphatase Peptidase_C2 PF00648.16 KOO34194.1 - 1.7e-39 135.6 0.0 2.3e-39 135.2 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.17 KOO34194.1 - 4.1e-24 84.9 0.0 1.1e-10 41.3 0.0 2.7 3 0 0 3 3 3 2 Calpain large subunit, domain III Helicase_C PF00271.26 KOO34195.1 - 8.5e-09 35.1 0.0 2.2e-08 33.8 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOO34195.1 - 5.8e-06 25.8 0.0 3.2e-05 23.4 0.0 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase Ribosomal_L4 PF00573.17 KOO34195.1 - 0.1 11.9 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L4/L1 family TPR_10 PF13374.1 KOO34195.1 - 1.3 9.0 6.9 5.5 7.0 0.4 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Peripla_BP_3 PF13377.1 KOO34195.1 - 6.2 6.7 9.7 1.1 9.2 1.6 2.9 3 0 0 3 3 3 0 Periplasmic binding protein-like domain ShK PF01549.19 KOO34196.1 - 5.6e-12 45.8 17.0 3.6e-06 27.2 2.5 3.1 3 0 0 3 3 3 2 ShK domain-like 2OG-FeII_Oxy_3 PF13640.1 KOO34196.1 - 1.8e-05 25.1 0.1 0.0001 22.7 0.0 2.1 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO34196.1 - 5.2e-05 23.4 0.1 8.6e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily WW PF00397.21 KOO34196.1 - 0.00026 20.7 1.1 0.00054 19.7 0.8 1.6 1 0 0 1 1 1 1 WW domain 2OG-FeII_Oxy_4 PF13661.1 KOO34196.1 - 0.035 13.7 0.3 0.084 12.5 0.2 1.7 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Acatn PF13000.2 KOO34197.1 - 1.8e-75 254.5 9.2 2.1e-52 178.3 0.8 3.1 2 1 0 2 2 2 2 Acetyl-coenzyme A transporter 1 TcdA_TcdB_pore PF12920.2 KOO34199.1 - 0.019 12.9 0.1 0.019 12.9 0.1 2.0 1 1 1 2 2 2 0 TcdA/TcdB pore forming domain HET PF06985.6 KOO34200.1 - 0.046 13.8 0.3 0.43 10.7 0.0 2.2 1 1 1 2 2 2 0 Heterokaryon incompatibility protein (HET) DUF4126 PF13548.1 KOO34201.1 - 1.7e-25 89.5 19.7 1.7e-25 89.5 13.7 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4126) Peptidase_C2 PF00648.16 KOO34201.1 - 0.00021 20.3 0.0 0.00033 19.7 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease NAD_binding_1 PF00175.16 KOO34203.1 - 1.7e-15 57.5 0.0 2.3e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 KOO34203.1 - 8.8e-05 22.4 0.0 0.0037 17.1 0.0 2.0 2 0 0 2 2 2 2 Ferric reductase NAD binding domain Arm PF00514.18 KOO34205.1 - 1.3e-78 256.4 52.5 2.6e-08 33.3 0.3 12.8 13 0 0 13 13 13 11 Armadillo/beta-catenin-like repeat PARP PF00644.15 KOO34205.1 - 5.8e-09 35.6 0.0 1.4e-08 34.4 0.0 1.6 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Arm_2 PF04826.8 KOO34205.1 - 2.3e-07 30.1 7.9 0.13 11.3 0.1 5.0 3 2 3 7 7 7 4 Armadillo-like SdiA-regulated PF06977.6 KOO34205.1 - 0.026 13.5 0.0 2.2 7.1 0.0 3.0 2 1 1 3 3 3 0 SdiA-regulated RHS_repeat PF05593.9 KOO34205.1 - 0.039 14.1 0.0 17 5.7 0.0 3.2 2 0 0 2 2 2 0 RHS Repeat Protein_K PF12283.3 KOO34205.1 - 0.3 10.9 2.2 2e+02 1.9 0.0 5.4 7 0 0 7 7 7 0 Bacteriophage protein K Reprolysin_5 PF13688.1 KOO34205.1 - 2 8.3 7.2 82 3.0 0.0 4.7 1 1 2 4 4 4 0 Metallo-peptidase family M12 Thioredoxin PF00085.15 KOO34206.1 - 1.6e-09 37.3 0.0 6.6e-08 32.1 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.1 KOO34206.1 - 0.027 14.6 0.1 9.8 6.4 0.0 2.5 2 1 0 2 2 2 0 Thioredoxin-like domain TraF PF13728.1 KOO34206.1 - 0.066 12.7 0.0 6.3 6.2 0.0 2.1 2 0 0 2 2 2 0 F plasmid transfer operon protein Thioredoxin_8 PF13905.1 KOO34206.1 - 0.11 12.6 0.0 14 5.8 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin-like DUF2564 PF10819.3 KOO34208.1 - 0.026 14.6 0.5 0.026 14.6 0.3 4.4 2 1 2 4 4 4 0 Protein of unknown function (DUF2564) SIR2_2 PF13289.1 KOO34209.1 - 7.9e-21 74.4 0.0 1.4e-20 73.6 0.0 1.3 1 0 0 1 1 1 1 SIR2-like domain DUF676 PF05057.9 KOO34210.1 - 2.4e-21 76.0 0.0 3.5e-21 75.5 0.0 1.1 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_5 PF12695.2 KOO34210.1 - 0.016 14.9 0.0 0.02 14.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family PPR_2 PF13041.1 KOO34211.1 - 5.1e-15 55.1 0.0 8.3e-08 32.0 0.0 2.7 2 1 1 3 3 3 2 PPR repeat family PPR_3 PF13812.1 KOO34211.1 - 6.7e-09 35.3 3.6 0.002 18.2 0.0 5.7 6 0 0 6 6 6 2 Pentatricopeptide repeat domain PPR_1 PF12854.2 KOO34211.1 - 1.2e-08 34.2 5.8 0.00071 18.9 0.0 3.3 4 0 0 4 4 4 2 PPR repeat PPR PF01535.15 KOO34211.1 - 1.4e-06 27.8 3.3 0.12 12.3 0.0 4.3 5 0 0 5 5 5 3 PPR repeat PGM_PMM_I PF02878.11 KOO34213.1 - 3e-32 111.0 0.0 4.6e-32 110.3 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.11 KOO34213.1 - 9.5e-24 83.6 0.0 1.8e-23 82.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.11 KOO34213.1 - 2.2e-10 40.7 0.0 7.8e-10 39.0 0.0 2.0 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 KOO34213.1 - 1.8e-08 34.2 0.0 4.6e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain bPH_2 PF03703.9 KOO34214.1 - 1.5e-11 44.1 0.2 2.3e-11 43.5 0.1 1.3 1 0 0 1 1 1 1 Bacterial PH domain Flt3_lig PF02947.9 KOO34214.1 - 0.11 12.4 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 flt3 ligand APP_E2 PF12925.2 KOO34215.1 - 0.026 14.0 0.1 0.028 13.9 0.1 1.1 1 0 0 1 1 1 0 E2 domain of amyloid precursor protein DUF4129 PF13559.1 KOO34215.1 - 0.05 13.5 5.1 0.051 13.5 1.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4129) Chloroa_b-bind PF00504.16 KOO34217.1 - 1.1e-31 110.2 0.0 1.4e-31 109.8 0.0 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein RhoGEF PF00621.15 KOO34218.1 - 1.6e-24 86.7 0.0 1.9e-24 86.5 0.0 1.0 1 0 0 1 1 1 1 RhoGEF domain Glycos_transf_2 PF00535.21 KOO34220.1 - 1.9e-13 50.4 0.0 2.9e-12 46.5 0.0 2.4 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 KOO34220.1 - 5.1e-05 23.1 0.2 0.00087 19.1 0.1 2.4 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.4 KOO34220.1 - 0.00031 19.9 0.0 0.019 14.0 0.0 2.3 2 1 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.1 KOO34220.1 - 0.0033 17.6 0.1 0.03 14.6 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 2 Pkinase PF00069.20 KOO34223.1 - 2.1e-48 164.7 0.0 3e-48 164.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34223.1 - 7.6e-41 139.8 0.0 1.3e-40 139.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO34223.1 - 0.00045 19.2 0.0 0.00079 18.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO34223.1 - 0.07 12.8 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF1253 PF06862.7 KOO34224.1 - 7.9e-34 116.8 0.0 1.1e-33 116.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1253) DUF4326 PF14216.1 KOO34225.1 - 2.9e-09 37.3 0.3 2.3e-08 34.4 0.0 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF4326) Phage_integrase PF00589.17 KOO34225.1 - 0.0013 18.4 0.1 0.09 12.4 0.0 2.3 2 0 0 2 2 2 2 Phage integrase family NmrA PF05368.8 KOO34226.1 - 7.1e-46 156.3 0.0 1.2e-45 155.5 0.0 1.4 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.1 KOO34226.1 - 3e-12 46.9 0.1 5.1e-12 46.1 0.1 1.4 1 0 0 1 1 1 1 NADH(P)-binding Saccharop_dh PF03435.13 KOO34226.1 - 8.4e-05 21.7 0.3 0.00012 21.2 0.2 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase adh_short PF00106.20 KOO34226.1 - 0.00095 19.1 2.0 0.0011 18.9 0.6 1.6 1 1 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.16 KOO34226.1 - 0.00098 18.6 0.1 0.0013 18.2 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 KOO34226.1 - 0.002 16.8 0.0 0.0028 16.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.5 KOO34226.1 - 0.0053 16.4 0.4 0.0084 15.7 0.3 1.4 1 0 0 1 1 1 1 KR domain Semialdhyde_dh PF01118.19 KOO34226.1 - 0.14 12.4 0.7 0.35 11.1 0.5 1.7 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Abhydrolase_6 PF12697.2 KOO34227.1 - 6.1e-32 111.3 2.0 8.2e-32 110.9 1.4 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO34227.1 - 1.2e-12 47.7 0.0 2e-12 47.0 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO34227.1 - 2.7e-07 30.3 0.0 1.4e-05 24.7 0.0 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.15 KOO34227.1 - 3e-07 30.9 0.2 1.1e-06 29.0 0.0 1.9 2 0 0 2 2 2 1 Thioesterase domain DUF2305 PF10230.4 KOO34227.1 - 0.0011 18.3 0.0 0.0017 17.8 0.0 1.3 1 1 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Ser_hydrolase PF06821.8 KOO34227.1 - 0.05 13.1 0.0 0.15 11.6 0.0 1.8 1 1 0 1 1 1 0 Serine hydrolase DUF3089 PF11288.3 KOO34227.1 - 0.053 12.6 0.0 0.087 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) FAD-oxidase_C PF02913.14 KOO34228.1 - 2.1e-61 207.3 0.0 1e-60 205.1 0.0 1.9 2 0 0 2 2 2 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 KOO34228.1 - 8.9e-35 119.1 3.2 1.6e-34 118.3 2.2 1.4 1 0 0 1 1 1 1 FAD binding domain Ank_2 PF12796.2 KOO34229.1 - 3e-80 264.6 33.6 1.3e-19 70.2 1.4 7.3 1 1 7 8 8 8 7 Ankyrin repeats (3 copies) Ank PF00023.25 KOO34229.1 - 7.8e-56 183.2 65.6 6.9e-06 25.6 0.0 14.4 14 0 0 14 14 14 13 Ankyrin repeat Ank_4 PF13637.1 KOO34229.1 - 1.4e-55 184.7 19.0 4.6e-10 39.7 0.1 9.9 6 3 7 13 13 13 11 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO34229.1 - 2.2e-52 173.8 46.5 1.5e-08 34.5 0.2 11.7 1 1 12 13 13 13 13 Ankyrin repeats (many copies) Pkinase PF00069.20 KOO34229.1 - 1.9e-30 105.9 0.0 3.1e-30 105.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ank_3 PF13606.1 KOO34229.1 - 7e-27 90.8 25.0 0.003 17.6 0.0 13.4 13 0 0 13 13 13 8 Ankyrin repeat Pkinase_Tyr PF07714.12 KOO34229.1 - 4.9e-22 78.2 0.0 8.8e-22 77.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4182 PF13790.1 KOO34229.1 - 0.01 15.5 4.5 1.3 8.8 0.0 5.1 6 0 0 6 6 6 0 Domain of unknown function (DUF4182) Kinase-like PF14531.1 KOO34229.1 - 0.23 10.3 0.0 0.6 9.0 0.0 1.6 1 0 0 1 1 1 0 Kinase-like Ank_2 PF12796.2 KOO34230.1 - 1.8e-41 140.3 10.5 1.7e-18 66.7 0.6 5.0 1 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 KOO34230.1 - 9.1e-29 97.8 28.4 3.1e-07 29.8 0.4 9.1 9 0 0 9 9 9 6 Ankyrin repeat Ank_4 PF13637.1 KOO34230.1 - 3.3e-28 97.5 4.8 1.1e-10 41.6 0.1 6.2 5 2 2 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO34230.1 - 7.3e-25 86.4 18.9 8.4e-06 25.8 0.4 7.5 3 1 4 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO34230.1 - 3.8e-17 60.6 10.0 0.0086 16.2 0.1 8.6 9 0 0 9 9 9 4 Ankyrin repeat F-box-like PF12937.2 KOO34230.1 - 0.00023 20.8 0.2 0.00075 19.1 0.1 2.0 1 0 0 1 1 1 1 F-box-like RCC1 PF00415.13 KOO34231.1 - 1.4e-44 150.0 20.3 3.6e-12 46.3 0.0 7.9 6 2 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO34231.1 - 1.4e-32 110.5 38.8 8e-09 34.8 1.2 6.9 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat SpoVS PF04232.7 KOO34233.1 - 6.7e-07 28.7 0.0 7e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 Stage V sporulation protein S (SpoVS) PDZ PF00595.19 KOO34234.1 - 1.1e-06 28.7 0.0 1.2e-06 28.5 0.0 1.0 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO34234.1 - 0.033 14.0 0.0 0.041 13.7 0.0 1.4 1 1 0 1 1 1 0 PDZ domain Carb_kinase PF01256.12 KOO34237.1 - 1.1e-45 155.8 0.0 1.3e-45 155.5 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate kinase Phos_pyr_kin PF08543.7 KOO34237.1 - 0.04 13.1 0.0 0.057 12.6 0.0 1.2 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase EF-hand_1 PF00036.27 KOO34238.1 - 1.9e-06 26.7 0.4 4.7e-06 25.5 0.1 1.8 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO34238.1 - 3.6e-05 23.2 0.1 0.00041 19.9 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.1 KOO34238.1 - 8e-05 22.6 0.1 0.0048 16.9 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO34238.1 - 0.0074 15.5 0.6 0.022 14.0 0.1 2.0 2 0 0 2 2 2 1 EF hand Gas_vesicle_C PF01304.12 KOO34239.1 - 0.042 13.4 1.7 0.18 11.4 1.2 2.2 1 0 0 1 1 1 0 Gas vesicles protein GVPc repeated domain TetR PF13972.1 KOO34239.1 - 0.086 12.2 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial transcriptional repressor DUF4447 PF14590.1 KOO34239.1 - 0.086 12.4 0.3 2.1 7.8 0.0 2.6 2 1 0 3 3 3 0 Domain of unknown function (DUF4447) Hexapep_2 PF14602.1 KOO34240.1 - 0.067 12.7 0.5 0.21 11.1 0.3 1.9 1 0 0 1 1 1 0 Hexapeptide repeat of succinyl-transferase TATR PF03430.8 KOO34241.1 - 8.9 4.8 10.4 12 4.4 7.2 1.1 1 0 0 1 1 1 0 Trans-activating transcriptional regulator Pkinase PF00069.20 KOO34243.1 - 1.9e-75 253.4 0.0 2.3e-75 253.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34243.1 - 1.5e-43 148.7 0.0 1.9e-43 148.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO34243.1 - 3.6e-08 32.7 0.0 1.6e-07 30.5 0.0 1.8 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 KOO34243.1 - 3.2e-05 23.3 0.1 5.1e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 RIO1 family YukC PF10140.4 KOO34243.1 - 0.00046 18.8 0.0 0.00067 18.3 0.0 1.2 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC APH PF01636.18 KOO34243.1 - 0.0011 18.8 0.0 0.003 17.3 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 KOO34243.1 - 0.0014 17.7 0.1 0.0033 16.5 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 KOO34243.1 - 0.045 13.3 0.1 0.1 12.1 0.1 1.6 1 1 0 1 1 1 0 Choline/ethanolamine kinase DUF1908 PF08926.6 KOO34243.1 - 0.053 12.2 0.1 0.092 11.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1908) eIF3_N PF09440.5 KOO34244.1 - 0.2 11.8 5.5 0.38 10.9 3.8 1.4 1 0 0 1 1 1 0 eIF3 subunit 6 N terminal domain Spore_coat_CotO PF14153.1 KOO34244.1 - 2.6 7.4 9.5 3.4 7.0 6.6 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Exonuc_VII_L PF02601.10 KOO34244.1 - 8.5 5.4 11.6 13 4.9 8.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Borrelia_P83 PF05262.6 KOO34244.1 - 9.7 4.3 12.9 12 4.0 9.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein adh_short PF00106.20 KOO34245.1 - 0.0028 17.6 0.0 0.066 13.1 0.0 2.3 2 0 0 2 2 2 1 short chain dehydrogenase LRR_6 PF13516.1 KOO34246.1 - 3.7e-08 32.6 7.2 0.0042 17.0 0.0 4.3 4 0 0 4 4 4 3 Leucine Rich repeat LRR_1 PF00560.28 KOO34246.1 - 0.00025 20.6 0.1 13 6.3 0.0 4.4 4 0 0 4 4 4 2 Leucine Rich Repeat LRR_4 PF12799.2 KOO34246.1 - 0.0015 18.0 0.0 0.13 11.9 0.0 2.9 2 1 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO34246.1 - 0.0044 16.7 0.4 27 4.6 0.0 4.1 4 0 0 4 4 4 0 Leucine rich repeat NACHT PF05729.7 KOO34246.1 - 0.0063 16.1 0.0 0.014 15.0 0.0 1.6 1 0 0 1 1 1 1 NACHT domain LRR_7 PF13504.1 KOO34246.1 - 0.015 15.3 4.4 16 6.2 0.1 4.4 4 0 0 4 4 4 0 Leucine rich repeat GCD14 PF08704.5 KOO34247.1 - 2.3e-51 174.6 0.0 2.9e-51 174.3 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_26 PF13659.1 KOO34247.1 - 4e-08 33.2 1.9 4.3e-08 33.1 0.3 1.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO34247.1 - 1.2e-05 25.8 0.1 1.8e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO34247.1 - 4.6e-05 23.0 0.0 6.5e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.1 KOO34247.1 - 0.00025 21.8 0.2 0.00041 21.1 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 KOO34247.1 - 0.0028 17.2 0.0 0.0036 16.8 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.15 KOO34247.1 - 0.0042 16.1 0.0 0.0059 15.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase MTS PF05175.9 KOO34247.1 - 0.0096 15.3 0.1 0.014 14.7 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase small domain DUF4604 PF15377.1 KOO34248.1 - 0.017 15.3 5.7 0.023 14.9 4.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Ndc1_Nup PF09531.5 KOO34248.1 - 0.3 9.4 1.4 0.29 9.5 1.0 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Neurokinin_B PF03823.9 KOO34250.1 - 0.046 13.4 0.6 0.081 12.6 0.4 1.4 1 0 0 1 1 1 0 Neurokinin B Pkinase PF00069.20 KOO34251.1 - 2.6e-50 170.9 0.0 3.5e-50 170.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34251.1 - 2.6e-25 89.0 0.0 3.5e-25 88.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO34251.1 - 1.3e-05 25.0 0.1 1.3e-05 25.0 0.1 2.6 2 2 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO34251.1 - 4e-05 22.7 0.0 5.4e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Choline_kinase PF01633.15 KOO34251.1 - 0.18 11.3 0.0 0.31 10.5 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Peptidase_M8 PF01457.11 KOO34252.1 - 2.3e-83 280.3 0.0 2.8e-83 280.0 0.0 1.1 1 0 0 1 1 1 1 Leishmanolysin TIG PF01833.19 KOO34252.1 - 0.00019 21.3 0.0 0.00037 20.4 0.0 1.4 1 0 0 1 1 1 1 IPT/TIG domain DUF2818 PF10993.3 KOO34252.1 - 0.039 14.4 0.5 0.092 13.2 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2818) Chloroa_b-bind PF00504.16 KOO34253.1 - 6e-29 101.3 0.0 8.2e-29 100.8 0.0 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Abhydrolase_6 PF12697.2 KOO34254.1 - 8.3e-07 29.1 3.9 8.3e-07 29.1 2.7 2.0 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO34254.1 - 0.0068 16.1 0.0 0.015 15.0 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Sex_peptide PF08138.6 KOO34255.1 - 0.11 12.3 0.1 0.24 11.2 0.1 1.6 1 0 0 1 1 1 0 Sex peptide (SP) family LRR_6 PF13516.1 KOO34256.1 - 2.6e-29 97.9 0.4 0.00016 21.4 0.0 6.1 6 0 0 6 6 6 5 Leucine Rich repeat LRR_4 PF12799.2 KOO34256.1 - 8.6e-11 41.2 0.3 0.00097 18.7 0.0 4.6 3 2 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO34256.1 - 4.3e-08 32.1 0.0 46 4.6 0.0 6.0 6 0 0 6 6 6 0 Leucine Rich Repeat SpoU_sub_bind PF08032.7 KOO34256.1 - 4.5e-07 29.9 1.6 0.43 10.7 0.0 4.5 4 1 1 5 5 5 2 RNA 2'-O ribose methyltransferase substrate binding LRR_8 PF13855.1 KOO34256.1 - 3.9e-06 26.5 2.2 0.15 11.8 0.0 4.8 1 1 4 5 5 5 4 Leucine rich repeat LRR_7 PF13504.1 KOO34256.1 - 7.8e-06 25.2 1.4 74 4.2 0.0 5.5 6 0 0 6 6 6 0 Leucine rich repeat CbiG_N PF11760.3 KOO34256.1 - 0.0026 17.3 9.6 3 7.6 0.1 4.2 3 2 2 5 5 5 3 Cobalamin synthesis G N-terminal DUF2202 PF09968.4 KOO34256.1 - 0.19 11.3 1.5 11 5.6 0.0 3.1 1 1 2 3 3 3 0 Uncharacterized protein domain (DUF2202) Phage_integ_N PF09003.5 KOO34256.1 - 0.67 9.6 3.0 25 4.6 0.0 3.4 3 0 0 3 3 3 0 Bacteriophage lambda integrase, N-terminal domain OapA_N PF08525.6 KOO34257.1 - 0.17 11.6 0.4 0.35 10.6 0.3 1.5 1 0 0 1 1 1 0 Opacity-associated protein A N-terminal motif Chloroa_b-bind PF00504.16 KOO34258.1 - 9.8e-27 94.1 0.0 2.1e-26 93.0 0.0 1.5 1 1 0 1 1 1 1 Chlorophyll A-B binding protein DUF1395 PF07160.7 KOO34259.1 - 0.00071 19.1 0.1 0.00078 19.0 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1395) Mating_N PF12731.2 KOO34259.1 - 0.013 15.3 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 0 Mating-type protein beta 1 Phage_int_SAM_1 PF02899.12 KOO34259.1 - 0.084 13.0 0.1 0.11 12.6 0.1 1.4 1 1 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain PfUIS3 PF11567.3 KOO34259.1 - 0.12 12.5 0.0 0.4 10.8 0.0 1.8 1 1 1 2 2 2 0 Plasmodium falciparum UIS3 membrane protein Interferon PF00143.14 KOO34259.1 - 0.13 12.1 0.1 0.14 12.0 0.1 1.1 1 0 0 1 1 1 0 Interferon alpha/beta domain DUF2267 PF10025.4 KOO34259.1 - 0.14 12.2 0.1 0.21 11.6 0.1 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) Cupin_8 PF13621.1 KOO34260.1 - 8.3e-22 77.8 0.0 1.4e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain TPR_11 PF13414.1 KOO34260.1 - 1.1e-16 60.2 1.1 9.4e-07 28.3 0.1 3.2 1 1 2 3 3 3 3 TPR repeat TPR_2 PF07719.12 KOO34260.1 - 8.3e-16 56.5 6.3 0.00085 19.0 0.0 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.1 KOO34260.1 - 1.2e-14 54.5 17.1 1.7e-07 31.7 0.1 3.9 2 1 2 4 4 3 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO34260.1 - 8.1e-11 41.2 0.0 0.079 13.1 0.0 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOO34260.1 - 2.7e-10 40.0 1.5 2.7e-05 24.0 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO34260.1 - 1.1e-07 32.1 0.9 0.0084 16.4 0.1 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO34260.1 - 2e-07 31.0 12.5 0.009 16.5 0.0 4.9 3 1 2 5 5 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO34260.1 - 7e-06 25.4 1.8 0.00054 19.4 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO34260.1 - 1.4e-05 24.5 2.1 0.4 10.5 0.0 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO34260.1 - 0.0019 17.8 0.0 0.32 10.8 0.0 3.8 4 1 1 5 5 5 1 Tetratricopeptide repeat Cupin_4 PF08007.7 KOO34260.1 - 0.0041 16.4 0.0 0.18 10.9 0.0 2.3 2 0 0 2 2 2 1 Cupin superfamily protein TPR_4 PF07721.9 KOO34260.1 - 0.04 14.3 3.2 0.04 14.3 2.2 6.0 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO34260.1 - 0.11 12.3 0.3 0.11 12.3 0.2 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO34260.1 - 3 8.5 6.4 87 3.9 1.0 4.1 5 0 0 5 5 4 0 Tetratricopeptide repeat NAD_binding_1 PF00175.16 KOO34261.1 - 7.8e-24 84.3 0.0 1.3e-23 83.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 KOO34261.1 - 0.00032 20.7 0.0 0.00056 19.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain FAD_binding_1 PF00667.15 KOO34261.1 - 0.0018 17.7 0.0 0.18 11.2 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Arm PF00514.18 KOO34262.1 - 0.00058 19.5 1.7 1 9.3 0.3 4.6 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat LisH PF08513.6 KOO34262.1 - 0.019 14.7 0.2 0.039 13.7 0.1 1.6 1 0 0 1 1 1 0 LisH HEAT_EZ PF13513.1 KOO34262.1 - 0.38 11.3 13.7 0.43 11.1 0.3 4.6 4 2 0 4 4 4 0 HEAT-like repeat Rsa3 PF14615.1 KOO34263.1 - 0.082 12.2 0.2 0.18 11.1 0.2 1.5 1 0 0 1 1 1 0 Ribosome-assembly protein 3 RRM_5 PF13893.1 KOO34264.1 - 5.6e-06 26.1 0.0 1.4e-05 24.8 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOO34264.1 - 0.00014 21.4 0.1 0.00046 19.7 0.1 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO34264.1 - 0.005 16.7 0.0 0.0078 16.1 0.0 1.3 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Dynamin_N PF00350.18 KOO34265.1 - 4.2e-27 95.0 0.0 5.8e-27 94.5 0.0 1.2 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 KOO34265.1 - 0.00037 20.4 0.0 0.0014 18.5 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.11 KOO34265.1 - 0.0022 17.1 0.1 0.97 8.4 0.0 2.4 2 0 0 2 2 2 2 AIG1 family Miro PF08477.8 KOO34265.1 - 0.0035 17.8 0.0 0.0082 16.6 0.0 1.6 2 0 0 2 2 2 1 Miro-like protein F_actin_bind PF08919.5 KOO34265.1 - 0.09 12.4 0.2 0.18 11.5 0.2 1.4 1 0 0 1 1 1 0 F-actin binding zf-CCCH PF00642.19 KOO34267.1 - 1.2e-08 34.4 0.6 1.9e-08 33.8 0.4 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) YjeF_N PF03853.10 KOO34267.1 - 0.0057 16.2 0.0 0.0075 15.8 0.0 1.2 1 0 0 1 1 1 1 YjeF-related protein N-terminus zf-CCCH_2 PF14608.1 KOO34267.1 - 0.032 14.2 0.3 0.052 13.5 0.2 1.3 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type PhyH PF05721.8 KOO34268.1 - 0.0024 17.9 0.0 0.0032 17.5 0.0 1.3 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) CAP_GLY PF01302.20 KOO34270.1 - 0.069 12.8 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 CAP-Gly domain Methyltransf_32 PF13679.1 KOO34272.1 - 0.0072 16.0 0.0 0.0089 15.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain AAA_7 PF12775.2 KOO34274.1 - 8.3e-25 87.3 0.0 9.1e-25 87.2 0.0 1.0 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_8 PF12780.2 KOO34275.1 - 1.3e-69 234.1 0.0 1.9e-69 233.6 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.2 KOO34275.1 - 1.8e-57 193.8 4.5 1e-56 191.3 0.1 3.4 4 0 0 4 4 4 1 ATP-binding dynein motor region D5 MT PF12777.2 KOO34275.1 - 3.9e-46 157.3 6.4 6.7e-46 156.6 4.4 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor PEARLI-4 PF05278.7 KOO34275.1 - 0.0091 15.3 3.0 0.0091 15.3 2.1 2.3 3 1 1 4 4 4 1 Arabidopsis phospholipase-like protein (PEARLI 4) VHS PF00790.14 KOO34276.1 - 0.054 13.1 0.2 0.062 12.9 0.1 1.1 1 0 0 1 1 1 0 VHS domain ADIP PF11559.3 KOO34276.1 - 0.064 13.1 3.9 0.1 12.5 2.7 1.4 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding Tape_meas_lam_C PF09718.5 KOO34276.1 - 0.087 12.7 3.4 0.13 12.2 2.3 1.2 1 0 0 1 1 1 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) Filament PF00038.16 KOO34276.1 - 0.092 12.2 7.0 0.11 11.9 4.8 1.0 1 0 0 1 1 1 0 Intermediate filament protein Borrelia_P83 PF05262.6 KOO34276.1 - 0.18 10.0 10.3 0.19 9.9 7.1 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein TMEM247 PF15444.1 KOO34276.1 - 0.21 11.3 1.0 0.23 11.2 0.7 1.0 1 0 0 1 1 1 0 Transmembrane protein 247 YlqD PF11068.3 KOO34276.1 - 1.1 9.3 6.1 1.3 9.0 4.2 1.1 1 0 0 1 1 1 0 YlqD protein DUF1451 PF07295.6 KOO34276.1 - 3.4 7.4 6.4 2.9 7.6 0.6 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1451) ERM PF00769.14 KOO34276.1 - 3.9 6.9 11.1 4.6 6.6 7.7 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family HisKA_3 PF07730.8 KOO34276.1 - 4.1 7.8 8.0 1 9.7 2.1 2.2 1 1 1 2 2 2 0 Histidine kinase MxiH PF09392.5 KOO34276.1 - 7 7.2 8.5 31 5.2 5.9 2.0 1 1 0 1 1 1 0 Type III secretion needle MxiH like GST_N_3 PF13417.1 KOO34277.1 - 1.9e-15 56.7 0.0 4.3e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 KOO34277.1 - 5.8e-10 39.0 0.0 1.1e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.15 KOO34277.1 - 3.5e-07 30.2 0.0 7.4e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 KOO34277.1 - 5.3e-07 29.4 0.5 1.2e-06 28.2 0.3 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 KOO34277.1 - 1.9e-05 24.5 0.1 3.1e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 KOO34277.1 - 0.012 16.1 0.0 0.019 15.4 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain PHD PF00628.24 KOO34278.1 - 1.7e-07 30.8 2.9 2.5e-07 30.2 1.0 2.1 2 1 0 2 2 2 1 PHD-finger YjbE PF11106.3 KOO34280.1 - 0.00052 19.9 6.5 0.0012 18.7 4.5 1.6 1 0 0 1 1 1 1 Exopolysaccharide production protein YjbE Pex24p PF06398.6 KOO34280.1 - 0.045 12.5 3.3 0.055 12.2 2.3 1.0 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Ion_trans PF00520.26 KOO34280.1 - 0.57 9.3 5.1 0.3 10.3 2.1 1.7 1 1 0 1 1 1 0 Ion transport protein P12 PF12669.2 KOO34280.1 - 0.84 9.8 0.1 0.84 9.8 0.1 3.8 4 0 0 4 4 4 0 Virus attachment protein p12 family PRA1 PF03208.14 KOO34280.1 - 5.2 6.3 12.8 6.3 6.1 3.6 2.2 2 0 0 2 2 2 0 PRA1 family protein Ank_2 PF12796.2 KOO34281.1 - 7e-07 29.5 0.2 0.00041 20.6 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO34281.1 - 7.5e-07 29.1 1.4 0.0015 18.6 0.1 4.5 3 1 1 4 4 4 1 Ankyrin repeats (many copies) TIR_2 PF13676.1 KOO34281.1 - 2.4e-06 27.6 0.0 1.2e-05 25.3 0.0 2.2 2 0 0 2 2 2 1 TIR domain Ank_4 PF13637.1 KOO34281.1 - 3e-05 24.3 0.5 0.047 14.2 0.0 4.4 3 1 2 5 5 5 2 Ankyrin repeats (many copies) PfkB PF00294.19 KOO34281.1 - 9.8e-05 21.6 0.4 0.00016 20.8 0.2 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Ank PF00023.25 KOO34281.1 - 0.00014 21.5 0.4 0.12 12.2 0.0 4.2 4 0 0 4 4 4 1 Ankyrin repeat Ank_3 PF13606.1 KOO34281.1 - 0.00028 20.8 0.6 1.5 9.2 0.0 4.8 5 0 0 5 5 5 1 Ankyrin repeat DUF1863 PF08937.6 KOO34281.1 - 0.0098 15.9 0.0 0.02 14.9 0.0 1.5 1 0 0 1 1 1 1 MTH538 TIR-like domain (DUF1863) TIR PF01582.15 KOO34281.1 - 0.019 14.4 0.0 0.036 13.5 0.0 1.4 1 0 0 1 1 1 0 TIR domain TPP_enzyme_M PF00205.17 KOO34281.1 - 0.078 12.7 0.1 0.18 11.5 0.1 1.5 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain His_Phos_1 PF00300.17 KOO34282.1 - 3.3e-07 30.5 0.0 6.3e-07 29.6 0.0 1.5 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) Cupin_4 PF08007.7 KOO34283.1 - 4.1e-26 91.9 0.0 1.8e-25 89.8 0.0 1.9 1 1 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.1 KOO34283.1 - 0.00041 19.9 0.0 0.0015 18.1 0.0 1.7 1 1 0 1 1 1 1 Cupin-like domain Cupin_2 PF07883.6 KOO34283.1 - 0.029 13.8 0.0 0.094 12.2 0.0 1.8 2 0 0 2 2 2 0 Cupin domain JmjC PF02373.17 KOO34283.1 - 0.093 12.9 0.0 1.9 8.7 0.0 2.3 2 0 0 2 2 2 0 JmjC domain, hydroxylase LRR_6 PF13516.1 KOO34284.1 - 2.3e-40 132.0 0.8 2.7e-05 23.7 0.0 8.2 8 0 0 8 8 8 7 Leucine Rich repeat LRR_4 PF12799.2 KOO34284.1 - 1.6e-08 33.9 0.9 0.13 11.8 0.0 5.7 4 2 2 6 6 6 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO34284.1 - 8.6e-07 28.1 0.0 13 6.2 0.0 6.1 7 1 0 7 7 7 0 Leucine Rich Repeat LRR_7 PF13504.1 KOO34284.1 - 8e-06 25.2 1.5 33 5.2 0.0 6.7 7 0 0 7 7 7 0 Leucine rich repeat YycC PF14174.1 KOO34284.1 - 0.00051 19.6 0.0 26 4.5 0.0 5.7 7 0 0 7 7 7 0 YycC-like protein SpoU_sub_bind PF08032.7 KOO34284.1 - 0.0019 18.2 4.2 0.85 9.8 0.0 4.3 3 2 0 4 4 4 1 RNA 2'-O ribose methyltransferase substrate binding Flu_M1 PF00598.14 KOO34284.1 - 0.019 14.4 0.0 8.4 5.7 0.0 3.4 1 1 1 3 3 3 0 Influenza Matrix protein (M1) HTH_3 PF01381.17 KOO34284.1 - 0.03 14.1 0.9 5 7.0 0.1 3.8 3 1 0 3 3 3 0 Helix-turn-helix CbiG_N PF11760.3 KOO34284.1 - 0.036 13.7 13.7 7 6.4 0.1 5.8 5 1 1 6 6 6 0 Cobalamin synthesis G N-terminal CTV_P13 PF06922.6 KOO34284.1 - 0.16 11.8 2.2 3.4 7.5 0.0 3.5 1 1 4 5 5 5 0 Citrus tristeza virus P13 protein CCDC71L PF15374.1 KOO34284.1 - 0.82 8.9 2.3 34 3.6 0.0 3.6 5 0 0 5 5 5 0 Coiled-coil domain-containing protein 71L DUF2202 PF09968.4 KOO34284.1 - 1.3 8.6 5.2 55 3.3 0.1 4.5 2 2 4 6 6 6 0 Uncharacterized protein domain (DUF2202) Homeobox PF00046.24 KOO34285.1 - 1.5e-08 34.0 0.2 1.9e-08 33.7 0.1 1.2 1 0 0 1 1 1 1 Homeobox domain A_deaminase PF00962.17 KOO34286.1 - 2.5e-97 325.7 0.1 3.4e-97 325.3 0.1 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase RIX1 PF08167.7 KOO34287.1 - 1.5e-10 40.9 0.1 2e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 rRNA processing/ribosome biogenesis HEAT PF02985.17 KOO34287.1 - 0.01 15.8 2.6 1.7 8.9 0.2 2.9 2 0 0 2 2 2 0 HEAT repeat FdhE PF04216.7 KOO34287.1 - 0.051 13.2 5.0 0.07 12.8 3.5 1.2 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation Polysacc_synt_3 PF13440.1 KOO34287.1 - 0.077 12.4 1.9 0.1 12.0 1.3 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein HEAT_2 PF13646.1 KOO34287.1 - 1 9.7 9.5 0.26 11.6 3.2 2.6 3 1 0 3 3 3 0 HEAT repeats Mito_carr PF00153.22 KOO34288.1 - 9.5e-41 137.4 3.5 2.3e-17 62.4 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein PARP PF00644.15 KOO34289.1 - 5.5e-12 45.5 0.0 2.2e-11 43.5 0.0 1.9 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DUF3653 PF12375.3 KOO34289.1 - 0.93 9.7 4.9 0.56 10.4 0.5 2.7 3 0 0 3 3 3 0 Phage protein Herpes_gE PF02480.11 KOO34290.1 - 0.072 11.3 0.0 0.11 10.7 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E MAD PF05557.8 KOO34291.1 - 0.016 13.3 14.3 0.022 12.8 9.9 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein Borrelia_P83 PF05262.6 KOO34291.1 - 0.034 12.4 8.4 0.048 11.9 5.8 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF2508 PF10704.4 KOO34291.1 - 0.11 12.7 4.3 0.29 11.3 3.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2508) DUF2205 PF10224.4 KOO34291.1 - 2.2 7.9 8.6 1.5 8.4 1.0 2.5 2 0 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) Suppressor_APC PF11414.3 KOO34291.1 - 4.6 7.1 9.6 3 7.6 0.8 2.6 2 0 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein EF-hand_1 PF00036.27 KOO34292.1 - 1.1e-41 136.9 0.4 1.6e-06 26.9 0.0 6.5 7 0 0 7 7 7 6 EF hand EF-hand_6 PF13405.1 KOO34292.1 - 9.9e-39 127.7 0.4 2.8e-05 23.6 0.0 6.8 6 1 1 7 7 7 6 EF-hand domain EF-hand_7 PF13499.1 KOO34292.1 - 8.7e-34 115.4 0.5 1.3e-09 38.0 0.1 3.7 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO34292.1 - 5.8e-31 104.4 0.4 2.7e-05 23.3 0.0 6.3 6 0 0 6 6 6 6 EF hand EF-hand_8 PF13833.1 KOO34292.1 - 1.9e-28 97.8 2.2 2.8e-08 33.2 0.0 5.5 3 3 3 6 6 6 6 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO34292.1 - 6.8e-06 26.0 0.0 1.3 9.0 0.0 3.2 3 0 0 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOO34292.1 - 0.0005 19.9 0.0 1.2 9.0 0.0 3.8 3 2 1 4 4 4 1 EF-hand domain EF-hand_4 PF12763.2 KOO34292.1 - 0.00069 19.3 0.6 8.9 6.1 0.0 4.5 3 3 2 5 5 5 1 Cytoskeletal-regulatory complex EF hand Peptidase_M10_C PF08548.6 KOO34292.1 - 0.056 13.0 0.7 1.6 8.2 0.0 2.9 3 0 0 3 3 3 0 Peptidase M10 serralysin C terminal EFhand_Ca_insen PF08726.5 KOO34292.1 - 0.073 13.0 0.2 49 3.9 0.0 3.7 4 0 0 4 4 4 0 Ca2+ insensitive EF hand HPPK PF01288.15 KOO34292.1 - 0.084 12.6 0.0 0.37 10.5 0.0 1.9 2 0 0 2 2 2 0 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) Pkinase PF00069.20 KOO34293.1 - 4e-56 190.0 0.0 8.6e-54 182.4 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34293.1 - 4.3e-26 91.5 0.0 9.6e-25 87.1 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO34293.1 - 6.4e-09 35.1 0.1 0.00073 18.5 0.0 3.1 3 0 0 3 3 3 3 Kinase-like NIT PF08376.5 KOO34293.1 - 0.014 14.9 0.2 0.022 14.3 0.1 1.3 1 0 0 1 1 1 0 Nitrate and nitrite sensing APH PF01636.18 KOO34293.1 - 0.04 13.6 5.3 0.11 12.2 0.1 3.0 2 1 1 3 3 3 0 Phosphotransferase enzyme family DUF4326 PF14216.1 KOO34294.1 - 3.9e-10 40.1 0.1 3.1e-09 37.2 0.0 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF4326) Rep_fac_C PF08542.6 KOO34294.1 - 0.39 10.7 0.0 0.74 9.8 0.0 1.4 1 0 0 1 1 1 0 Replication factor C C-terminal domain Kinesin PF00225.18 KOO34295.1 - 1.7e-13 49.9 0.0 8.9e-13 47.6 0.0 1.8 1 1 1 2 2 2 1 Kinesin motor domain EF-hand_7 PF13499.1 KOO34295.1 - 0.00015 21.8 0.0 0.0016 18.5 0.0 2.2 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO34295.1 - 0.00016 21.2 0.0 0.00033 20.2 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO34295.1 - 0.00039 20.0 0.0 0.0045 16.7 0.0 2.6 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.27 KOO34295.1 - 0.0025 17.0 0.0 0.029 13.6 0.0 2.6 2 0 0 2 2 2 1 EF hand Bacteriocin_IIc PF10439.4 KOO34295.1 - 9.9 6.3 12.9 40 4.4 8.9 2.1 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Herpes_UL25 PF01499.11 KOO34297.1 - 0.6 8.3 6.5 0.19 9.9 2.4 1.6 2 0 0 2 2 2 0 Herpesvirus UL25 family eIF-5a PF01287.15 KOO34298.1 - 5.1e-10 39.1 0.3 9.1e-10 38.3 0.2 1.4 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.7 KOO34298.1 - 0.036 13.9 0.0 0.075 12.9 0.0 1.5 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain Methyltransf_21 PF05050.7 KOO34299.1 - 3.1e-09 36.9 0.0 4.6e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain TehB PF03848.9 KOO34299.1 - 0.0044 16.1 0.0 0.0078 15.4 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_23 PF13489.1 KOO34299.1 - 0.0057 16.3 0.0 0.0096 15.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO34299.1 - 0.029 14.9 0.0 0.05 14.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Prog_receptor PF02161.10 KOO34300.1 - 0.15 10.8 0.3 0.18 10.5 0.2 1.1 1 0 0 1 1 1 0 Progesterone receptor HMG_box PF00505.14 KOO34301.1 - 8.8e-09 35.5 0.4 2.8e-08 33.9 0.3 1.8 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO34301.1 - 2.3e-05 24.6 1.6 7.2e-05 23.0 1.1 1.8 1 1 0 1 1 1 1 HMG-box domain Inhibitor_I29 PF08246.7 KOO34302.1 - 0.00042 20.5 0.0 0.00062 19.9 0.0 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) DUF3022 PF11226.3 KOO34302.1 - 0.0019 18.0 0.8 0.0037 17.1 0.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3022) SKG6 PF08693.5 KOO34303.1 - 0.23 10.7 3.2 0.5 9.7 1.4 2.1 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Ank_2 PF12796.2 KOO34304.1 - 1.3e-29 102.3 24.0 2.7e-16 59.6 1.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO34304.1 - 3.2e-24 84.8 0.2 2.2e-08 34.3 0.0 5.3 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.25 KOO34304.1 - 1.9e-19 68.4 27.0 4.2e-05 23.1 0.0 6.6 6 1 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.1 KOO34304.1 - 5.6e-18 64.5 17.9 1.8e-07 31.1 0.2 6.1 3 1 3 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO34304.1 - 2.6e-16 58.0 10.7 0.00072 19.5 0.0 6.2 5 0 0 5 5 5 4 Ankyrin repeat Crust_neuro_H PF03858.8 KOO34304.1 - 0.013 16.1 6.4 0.3 11.6 0.1 4.3 3 1 1 4 4 4 0 Crustacean neurohormone H HA2 PF04408.18 KOO34305.1 - 2.4e-15 56.3 0.0 9e-15 54.5 0.0 2.0 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 KOO34305.1 - 9.9e-15 54.3 0.0 2.1e-14 53.3 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 KOO34305.1 - 4.3e-12 45.7 0.0 8.8e-12 44.7 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOO34305.1 - 0.0001 21.8 0.1 0.00018 21.0 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-met PF12874.2 KOO34305.1 - 0.001 19.2 9.0 0.12 12.5 0.8 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 KOO34305.1 - 0.0053 16.8 7.9 0.25 11.5 0.1 3.2 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding KaiC PF06745.8 KOO34305.1 - 0.007 15.5 0.0 0.011 14.8 0.0 1.3 1 0 0 1 1 1 1 KaiC T2SE PF00437.15 KOO34305.1 - 0.0077 15.1 0.0 0.014 14.2 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein UPF0079 PF02367.12 KOO34305.1 - 0.013 15.1 0.0 0.033 13.8 0.0 1.7 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_22 PF13401.1 KOO34305.1 - 0.027 14.5 0.0 0.077 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 KOO34305.1 - 0.11 13.0 0.0 11 6.5 0.0 2.4 2 0 0 2 2 2 0 Miro-like protein MgtE PF01769.11 KOO34306.1 - 5.3e-18 65.6 6.3 1.1e-17 64.5 4.3 1.5 1 0 0 1 1 1 1 Divalent cation transporter Dpy-30 PF05186.8 KOO34306.1 - 0.0038 16.6 0.0 0.0081 15.6 0.0 1.6 1 0 0 1 1 1 1 Dpy-30 motif FKBP_C PF00254.23 KOO34307.1 - 6.7e-24 83.7 0.1 7.4e-24 83.5 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_1 PF00036.27 KOO34308.1 - 7.7e-23 78.0 10.2 1.6e-06 27.0 0.0 5.3 4 1 1 5 5 5 5 EF hand EF-hand_6 PF13405.1 KOO34308.1 - 3.1e-20 70.1 9.7 1.5e-07 30.6 0.0 5.4 4 1 1 5 5 5 5 EF-hand domain EF-hand_7 PF13499.1 KOO34308.1 - 7.6e-19 67.6 8.9 3.2e-10 39.9 0.0 3.8 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO34308.1 - 1.7e-10 39.7 12.3 4.7e-05 22.5 0.0 5.3 4 2 1 5 5 5 3 EF hand EF-hand_8 PF13833.1 KOO34308.1 - 4.1e-10 39.1 19.2 0.00061 19.3 0.7 5.5 2 2 3 5 5 5 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO34308.1 - 4.1e-07 30.0 0.8 0.0022 18.0 0.2 3.3 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO34308.1 - 0.00012 21.7 5.1 0.16 11.6 0.2 3.1 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO34308.1 - 0.00096 18.7 0.7 3 7.5 0.0 3.9 4 0 0 4 4 4 2 EF hand EF-hand_9 PF14658.1 KOO34308.1 - 0.066 13.1 0.9 6.7 6.6 0.0 3.0 2 1 0 2 2 2 0 EF-hand domain LRR_6 PF13516.1 KOO34309.1 - 1.3e-16 58.7 9.6 0.91 9.7 0.0 9.8 10 0 0 10 10 10 5 Leucine Rich repeat LRR_4 PF12799.2 KOO34309.1 - 2.3e-09 36.6 3.3 0.06 12.9 0.0 6.3 4 2 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO34309.1 - 4.6e-09 35.0 1.2 0.95 9.7 0.0 7.5 7 1 1 8 8 8 2 Leucine Rich Repeat LRR_7 PF13504.1 KOO34309.1 - 1.7e-08 33.2 5.6 2.1 8.8 0.0 8.9 9 0 0 9 9 9 2 Leucine rich repeat LRR_8 PF13855.1 KOO34309.1 - 0.00054 19.6 5.3 1.7 8.4 0.0 5.6 4 3 1 5 5 5 2 Leucine rich repeat RNase_HII PF01351.13 KOO34310.1 - 8.7e-37 126.6 0.0 1.6e-36 125.7 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease HII PsbW PF07123.7 KOO34310.1 - 2.6 8.1 7.6 8.2 6.4 5.3 1.8 1 0 0 1 1 1 0 Photosystem II reaction centre W protein (PsbW) ZZ PF00569.12 KOO34311.1 - 0.00027 20.4 0.0 0.00059 19.3 0.0 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type TATR PF03430.8 KOO34311.1 - 1.5 7.3 7.0 2 6.9 4.9 1.1 1 0 0 1 1 1 0 Trans-activating transcriptional regulator Pro_isomerase PF00160.16 KOO34312.1 - 1.8e-28 99.6 0.0 2.7e-28 99.1 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD BPS PF08947.5 KOO34312.1 - 1.5 8.4 5.3 0.92 9.1 1.8 1.9 1 1 1 2 2 2 0 BPS (Between PH and SH2) Peptidase_A22B PF04258.8 KOO34313.1 - 2.4e-47 161.8 6.5 4.6e-46 157.6 4.5 2.2 1 1 0 1 1 1 1 Signal peptide peptidase PA PF02225.17 KOO34313.1 - 2.1e-06 27.3 0.2 6.9e-06 25.6 0.2 1.9 1 0 0 1 1 1 1 PA domain LRR_5 PF13306.1 KOO34314.1 - 2e-72 240.9 0.1 6.8e-38 129.2 0.0 2.0 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO34314.1 - 1.9e-25 88.3 0.0 1.1e-06 28.3 0.0 4.6 1 1 5 6 6 6 6 Leucine rich repeat He_PIG PF05345.7 KOO34314.1 - 0.012 15.5 9.9 38 4.4 0.0 6.9 8 0 0 8 8 8 0 Putative Ig domain NUDIX-like PF09296.6 KOO34315.1 - 0.88 9.9 5.9 25 5.3 4.1 2.9 1 1 0 1 1 1 0 NADH pyrophosphatase-like rudimentary NUDIX domain Pkinase PF00069.20 KOO34316.1 - 4.8e-44 150.4 0.0 9.8e-44 149.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34316.1 - 1.4e-19 70.1 0.0 2e-19 69.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1513 PF07433.6 KOO34318.1 - 0.12 11.2 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1513) FKBP_C PF00254.23 KOO34319.1 - 1.3e-19 70.0 0.0 2e-19 69.3 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Zea_mays_MuDR PF05928.6 KOO34320.1 - 0.77 9.1 5.8 0.97 8.8 4.0 1.3 1 0 0 1 1 1 0 Zea mays MURB-like protein (MuDR) RRM_1 PF00076.17 KOO34321.1 - 2.1e-12 46.5 0.0 2.8e-05 23.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO34321.1 - 4e-09 36.1 0.0 3.4e-06 26.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO34321.1 - 0.0006 19.7 0.0 0.39 10.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Reo_sigmaC PF04582.7 KOO34322.1 - 0.0073 15.5 0.3 0.021 14.0 0.0 1.7 2 0 0 2 2 2 1 Reovirus sigma C capsid protein H-kinase_dim PF02895.9 KOO34322.1 - 1.7 9.0 6.2 1.1 9.6 0.1 2.8 2 1 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain Metallophos_2 PF12850.2 KOO34324.1 - 8.3e-09 35.4 0.0 1.5e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 KOO34324.1 - 1.1e-05 24.9 0.7 0.24 10.7 0.4 2.9 2 1 0 2 2 2 2 Calcineurin-like phosphoesterase REV PF00424.13 KOO34324.1 - 0.068 13.0 0.2 0.18 11.7 0.1 1.7 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) Tudor-knot PF11717.3 KOO34325.1 - 1.4e-07 31.0 0.3 2e-06 27.3 0.2 2.3 1 1 0 1 1 1 1 RNA binding activity-knot of a chromodomain PTCB-BRCT PF12738.2 KOO34325.1 - 0.13 12.1 0.0 2.1 8.2 0.0 2.4 2 0 0 2 2 2 0 twin BRCT domain HA PF03457.9 KOO34326.1 - 1.1e-32 111.9 1.7 1.2e-09 38.1 0.1 3.4 3 0 0 3 3 3 3 Helicase associated domain zf-DHHC PF01529.15 KOO34327.1 - 8.3e-16 57.8 10.4 8.3e-16 57.8 7.2 1.7 1 1 1 2 2 2 1 DHHC palmitoyltransferase 7tm_1 PF00001.16 KOO34327.1 - 0.06 12.4 2.0 0.26 10.3 0.2 2.0 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) DUF2189 PF09955.4 KOO34327.1 - 0.19 11.6 6.9 0.17 11.8 1.6 2.1 2 0 0 2 2 2 0 Predicted integral membrane protein (DUF2189) TPPK_C PF12555.3 KOO34327.1 - 0.68 9.7 3.4 2.1 8.1 0.1 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal GPI2 PF06432.6 KOO34327.1 - 2.9 7.1 8.2 1.2 8.4 1.9 2.0 2 0 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase CobD_Cbib PF03186.8 KOO34327.1 - 3.5 6.6 5.5 1.1 8.2 0.3 2.0 2 0 0 2 2 2 0 CobD/Cbib protein DUF2828 PF11443.3 KOO34328.1 - 2.3e-96 323.1 0.0 6e-82 275.5 0.0 3.0 1 1 1 2 2 2 2 Domain of unknown function (DUF2828) VWA_CoxE PF05762.9 KOO34328.1 - 1e-06 28.0 0.0 2e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein VWA_3 PF13768.1 KOO34328.1 - 0.00054 19.6 0.0 0.0022 17.7 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain Glyco_hydro_30 PF02055.11 KOO34329.1 - 2.9e-47 161.0 0.6 3.8e-26 91.3 0.1 2.9 3 0 0 3 3 3 3 O-Glycosyl hydrolase family 30 Glyco_hydro_30 PF02055.11 KOO34330.1 - 3.3e-18 65.1 0.0 6.4e-18 64.2 0.0 1.3 1 1 0 1 1 1 1 O-Glycosyl hydrolase family 30 TPR_12 PF13424.1 KOO34331.1 - 6.3e-57 189.4 15.9 9.4e-14 51.1 0.0 5.3 1 1 5 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.1 KOO34331.1 - 2.2e-44 148.1 16.8 2e-08 33.8 0.1 6.8 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_16 PF13432.1 KOO34331.1 - 2.1e-12 47.3 12.5 0.00018 22.0 0.1 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO34331.1 - 2.7e-12 45.5 5.7 0.21 11.5 0.0 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO34331.1 - 3.3e-11 42.0 6.2 0.01 15.5 0.0 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.1 KOO34331.1 - 2.9e-10 39.6 0.9 0.011 15.4 0.0 3.6 2 1 2 4 4 4 4 TPR repeat TPR_14 PF13428.1 KOO34331.1 - 4.1e-09 36.2 18.8 0.49 11.1 0.3 6.4 3 1 3 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.23 KOO34331.1 - 1.5e-08 33.9 1.6 0.79 9.4 0.0 6.0 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_4 PF07721.9 KOO34331.1 - 1.1e-07 31.6 7.9 1.5 9.4 0.0 6.3 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO34331.1 - 1.7e-07 31.4 7.5 0.0066 16.7 0.1 3.6 2 1 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO34331.1 - 2.2e-06 27.0 0.0 1.4 8.8 0.0 5.0 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO34331.1 - 0.00027 20.9 2.6 0.4 11.0 0.0 4.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_5 PF12688.2 KOO34331.1 - 0.0028 17.6 5.4 0.24 11.4 0.0 3.3 2 1 2 4 4 4 1 Tetratrico peptide repeat HisKA_3 PF07730.8 KOO34331.1 - 0.0035 17.6 6.3 0.58 10.5 0.0 4.3 4 2 1 5 5 5 1 Histidine kinase Osmo_CC PF08946.5 KOO34331.1 - 0.0057 16.6 0.0 0.4 10.7 0.0 3.7 4 0 0 4 4 4 1 Osmosensory transporter coiled coil TPR_3 PF07720.7 KOO34331.1 - 0.0092 15.7 0.6 0.21 11.4 0.0 3.3 5 0 0 5 5 5 1 Tetratricopeptide repeat DUF630 PF04783.7 KOO34331.1 - 0.071 13.0 3.4 41 4.1 0.1 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF630) TPR_6 PF13174.1 KOO34331.1 - 2.7 8.6 8.1 1.6e+02 3.0 0.0 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat LRR_4 PF12799.2 KOO34333.1 - 3.1e-21 74.5 17.0 6.5e-07 28.8 3.1 4.3 2 1 4 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO34333.1 - 4e-12 45.7 7.1 1.7e-05 24.4 0.0 3.5 1 1 2 3 3 3 3 Leucine rich repeat LRR_7 PF13504.1 KOO34333.1 - 3.8e-08 32.2 8.3 0.22 11.8 0.1 6.1 5 0 0 5 5 5 2 Leucine rich repeat LRR_6 PF13516.1 KOO34333.1 - 3.2e-07 29.7 5.4 5 7.5 0.2 5.8 5 0 0 5 5 5 3 Leucine Rich repeat LRR_9 PF14580.1 KOO34333.1 - 8.6e-07 28.6 0.1 0.00078 19.0 0.1 2.5 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.28 KOO34333.1 - 2.3e-05 23.7 8.3 2 8.7 0.7 5.3 4 1 1 5 5 5 2 Leucine Rich Repeat Mto2_bdg PF12808.2 KOO34333.1 - 0.0076 16.3 0.8 0.0076 16.3 0.6 2.6 2 1 1 3 3 3 1 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF904 PF06005.7 KOO34333.1 - 0.015 15.5 4.7 0.044 14.0 3.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF904) ATG16 PF08614.6 KOO34333.1 - 0.035 13.9 4.6 0.066 13.0 3.2 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.4 KOO34333.1 - 0.14 12.0 8.7 0.95 9.3 0.1 2.5 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3166 PF11365.3 KOO34333.1 - 0.34 11.4 5.1 7.4 7.0 1.4 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3166) DUF972 PF06156.8 KOO34333.1 - 0.37 11.1 5.2 0.84 10.0 2.6 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF972) TMF_TATA_bd PF12325.3 KOO34333.1 - 0.76 9.5 7.9 0.64 9.7 2.1 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding bZIP_2 PF07716.10 KOO34333.1 - 2 8.3 9.0 4.7 7.1 1.0 2.8 1 1 1 2 2 2 0 Basic region leucine zipper HALZ PF02183.13 KOO34333.1 - 4.6 7.0 12.9 1.3 8.8 0.6 3.1 2 1 1 3 3 3 0 Homeobox associated leucine zipper EF-hand_5 PF13202.1 KOO34334.1 - 4.6e-06 25.7 0.0 1e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KOO34334.1 - 0.0037 16.4 0.0 0.009 15.2 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO34334.1 - 0.022 14.6 0.0 0.055 13.3 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain EF-hand_8 PF13833.1 KOO34334.1 - 0.055 13.1 0.1 0.35 10.5 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain pair Myb_DNA-binding PF00249.26 KOO34337.1 - 5.2e-30 103.2 6.0 3.5e-14 52.5 0.1 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO34337.1 - 5.4e-24 84.0 2.5 2.6e-14 53.0 0.2 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain Sigma70_r4_2 PF08281.7 KOO34337.1 - 0.0011 18.3 0.0 0.0023 17.3 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 Peptidase_M10 PF00413.19 KOO34339.1 - 2.1e-06 27.5 0.0 0.00026 20.7 0.0 2.2 2 0 0 2 2 2 2 Matrixin Reprolysin_4 PF13583.1 KOO34339.1 - 0.014 14.9 0.0 0.021 14.3 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.1 KOO34339.1 - 0.029 14.4 0.0 0.046 13.7 0.0 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 KOO34339.1 - 0.03 14.2 0.0 0.041 13.8 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_3 PF13582.1 KOO34339.1 - 0.038 14.5 0.1 0.068 13.6 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like EF-hand_5 PF13202.1 KOO34339.1 - 0.087 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 EF hand Peptidase_M57 PF12388.3 KOO34339.1 - 0.16 11.2 0.0 0.29 10.4 0.0 1.4 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Arm PF00514.18 KOO34340.1 - 2.9e-08 33.2 19.8 0.021 14.6 0.1 7.8 8 0 0 8 8 8 4 Armadillo/beta-catenin-like repeat Hist_deacetyl PF00850.14 KOO34341.1 - 1.9e-53 181.7 0.1 2.7e-53 181.2 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Ank_2 PF12796.2 KOO34341.1 - 1.7e-15 57.0 19.0 4.8e-06 26.8 0.3 3.6 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 KOO34341.1 - 1.1e-14 53.4 9.6 3.7e-07 29.6 0.0 4.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.1 KOO34341.1 - 9.8e-13 48.2 3.3 0.0002 21.7 0.1 5.3 2 1 4 6 6 6 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO34341.1 - 1.4e-08 34.6 17.2 0.00034 20.7 0.1 5.4 5 1 0 5 5 5 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO34341.1 - 2.3e-07 30.4 3.7 0.011 15.8 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat TRL PF13146.1 KOO34341.1 - 0.059 13.3 0.0 19 5.3 0.0 2.6 2 0 0 2 2 2 0 TRL-like protein family HMG_box PF00505.14 KOO34342.1 - 7.2e-21 74.2 16.9 3.3e-15 56.0 0.4 3.0 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO34342.1 - 1.7e-18 66.7 18.0 2.9e-12 46.7 0.4 3.1 3 0 0 3 3 3 2 HMG-box domain DUF3106 PF11304.3 KOO34342.1 - 5.4 7.4 11.1 1.2 9.5 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) Ribosomal_L18e PF00828.14 KOO34343.1 - 9.7e-07 29.2 0.0 1.9e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 vMSA PF00695.14 KOO34343.1 - 0.19 10.8 0.0 0.24 10.5 0.0 1.1 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus ADH_zinc_N PF00107.21 KOO34345.1 - 8.5e-10 38.2 0.0 1.3e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 KOO34345.1 - 6.9e-05 23.7 0.0 0.00012 22.9 0.0 1.4 1 1 0 1 1 1 1 Zinc-binding dehydrogenase TRAPP PF04051.11 KOO34346.1 - 1.4e-37 128.5 0.0 1.6e-37 128.3 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Phosphoesterase PF04185.9 KOO34347.1 - 2.6e-50 171.7 0.1 9.4e-50 169.8 0.0 1.8 1 1 0 1 1 1 1 Phosphoesterase family Cupin_8 PF13621.1 KOO34348.1 - 6.2e-20 71.7 0.0 2e-12 47.1 0.2 2.1 1 1 0 2 2 2 2 Cupin-like domain Folate_rec PF03024.9 KOO34349.1 - 5.5e-21 74.8 17.2 2.2e-20 72.9 11.9 1.8 1 1 0 1 1 1 1 Folate receptor family SKG6 PF08693.5 KOO34349.1 - 9.9 5.5 8.5 25 4.3 5.9 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain JmjC PF02373.17 KOO34350.1 - 0.0018 18.4 0.0 0.41 10.8 0.0 2.1 2 0 0 2 2 2 2 JmjC domain, hydroxylase Cupin_8 PF13621.1 KOO34350.1 - 0.0021 17.5 0.0 0.0032 17.0 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain 2OG-FeII_Oxy_2 PF13532.1 KOO34354.1 - 3.6e-15 56.3 0.1 2e-13 50.6 0.1 2.0 1 1 1 2 2 2 2 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO34354.1 - 2.6e-06 27.6 0.0 4e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily AF-4 PF05110.8 KOO34354.1 - 0.016 13.1 0.7 0.019 12.8 0.5 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Glyco_hydro_92 PF07971.7 KOO34355.1 - 5.3e-79 266.1 0.0 6.7e-66 222.9 0.0 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 92 Arm PF00514.18 KOO34357.1 - 0.00018 21.1 1.0 0.53 10.1 0.2 3.1 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Kp4 PF09044.5 KOO34357.1 - 0.19 11.5 1.7 0.38 10.5 1.2 1.4 1 0 0 1 1 1 0 Kp4 Aldo_ket_red PF00248.16 KOO34358.1 - 8.2e-17 60.9 0.0 9.2e-17 60.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family TTL PF03133.10 KOO34359.1 - 2.8e-16 59.3 0.3 2.7e-15 56.0 0.6 1.8 1 1 1 2 2 2 2 Tubulin-tyrosine ligase family F-box-like PF12937.2 KOO34360.1 - 0.0016 18.1 0.2 0.0016 18.1 0.1 2.3 3 0 0 3 3 3 1 F-box-like F-box PF00646.28 KOO34360.1 - 0.025 14.2 1.6 0.036 13.7 0.0 2.1 2 0 0 2 2 2 0 F-box domain PH PF00169.24 KOO34361.1 - 0.0034 17.5 0.0 0.0066 16.6 0.0 1.4 1 0 0 1 1 1 1 PH domain Hexapep PF00132.19 KOO34361.1 - 0.12 11.9 0.2 1.1 8.8 0.1 2.3 2 0 0 2 2 2 0 Bacterial transferase hexapeptide (six repeats) PH_8 PF15409.1 KOO34361.1 - 0.26 11.4 0.0 0.53 10.3 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain HECA PF15353.1 KOO34362.1 - 4.3e-11 42.4 6.7 1.8e-08 34.0 4.6 2.8 2 1 0 2 2 2 1 Headcase protein family homologue RRM_6 PF14259.1 KOO34362.1 - 1.7e-08 34.2 0.0 3.9e-08 33.1 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOO34362.1 - 2e-07 30.5 0.1 6.3e-07 28.9 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TraV PF09676.5 KOO34362.1 - 2.8 8.6 7.7 5 7.8 0.1 2.5 2 0 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) PLRV_ORF5 PF01690.12 KOO34362.1 - 4.5 6.3 7.1 6.5 5.7 4.9 1.2 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein BacA PF02673.13 KOO34363.1 - 0.0083 15.3 0.2 0.015 14.5 0.1 1.4 1 0 0 1 1 1 1 Bacitracin resistance protein BacA Jiraiya PF15038.1 KOO34363.1 - 0.012 15.0 0.9 0.022 14.1 0.6 1.3 1 0 0 1 1 1 0 Jiraiya PDZ PF00595.19 KOO34368.1 - 2.5e-09 37.1 0.0 0.00069 19.7 0.0 2.3 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) OmpH PF03938.9 KOO34368.1 - 0.011 15.7 2.2 0.016 15.1 1.5 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) SurA_N_2 PF13623.1 KOO34368.1 - 0.033 14.1 0.1 0.05 13.5 0.1 1.2 1 0 0 1 1 1 0 SurA N-terminal domain SLD3 PF08639.5 KOO34368.1 - 0.14 10.7 3.2 0.19 10.3 2.2 1.1 1 0 0 1 1 1 0 DNA replication regulator SLD3 Ribosomal_L12 PF00542.14 KOO34368.1 - 1.9 8.5 6.2 31 4.6 0.0 2.7 2 0 0 2 2 2 0 Ribosomal protein L7/L12 C-terminal domain IlvC PF01450.14 KOO34370.1 - 0.11 12.4 0.1 0.33 10.8 0.1 1.9 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain Vps51 PF08700.6 KOO34370.1 - 0.21 11.4 4.7 11 5.9 0.0 4.8 5 0 0 5 5 5 0 Vps51/Vps67 DUF1664 PF07889.7 KOO34370.1 - 0.49 10.1 11.8 20 4.9 0.0 5.6 4 2 4 8 8 8 0 Protein of unknown function (DUF1664) DUF3584 PF12128.3 KOO34370.1 - 0.8 6.9 57.2 0.45 7.7 9.6 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF3584) Prominin PF05478.6 KOO34370.1 - 1.8 5.9 6.6 0.27 8.7 0.3 2.5 2 1 0 2 2 2 0 Prominin Baculo_PEP_C PF04513.7 KOO34370.1 - 2.1 8.1 15.4 2 8.2 1.0 4.7 2 1 2 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.5 KOO34370.1 - 8.1 6.5 9.9 2.3 8.3 0.4 3.8 3 2 1 4 4 4 0 Fibrinogen alpha/beta chain family Arm PF00514.18 KOO34371.1 - 8.3e-11 41.3 7.0 0.012 15.4 0.1 6.4 6 0 0 6 6 6 3 Armadillo/beta-catenin-like repeat HEAT PF02985.17 KOO34371.1 - 0.97 9.6 7.3 5.7 7.2 0.0 5.0 5 0 0 5 5 5 0 HEAT repeat Myosin_head PF00063.16 KOO34372.1 - 1.4e-172 575.3 0.0 1.4e-172 575.3 0.0 2.2 2 0 0 2 2 2 1 Myosin head (motor domain) AAA_17 PF13207.1 KOO34372.1 - 7.7e-05 23.4 0.5 0.00056 20.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 KOO34372.1 - 0.0027 17.8 0.0 0.0027 17.8 0.0 4.0 4 1 0 4 4 4 1 AAA domain AAA_18 PF13238.1 KOO34372.1 - 0.016 15.5 0.0 0.016 15.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain Rpr2 PF04032.11 KOO34372.1 - 0.08 12.8 0.1 0.44 10.4 0.1 2.3 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain RNA_helicase PF00910.17 KOO34372.1 - 0.12 12.5 0.0 0.4 10.8 0.0 1.9 2 0 0 2 2 2 0 RNA helicase Dynamin_N PF00350.18 KOO34373.1 - 1.8e-22 79.9 0.0 2.5e-10 40.4 0.0 2.3 1 1 1 2 2 2 2 Dynamin family EF-hand_4 PF12763.2 KOO34373.1 - 8e-21 73.7 0.0 2.3e-20 72.2 0.0 1.8 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand MMR_HSR1 PF01926.18 KOO34373.1 - 2.8e-10 40.1 0.0 9e-10 38.5 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase Miro PF08477.8 KOO34373.1 - 0.00015 22.2 0.0 0.002 18.6 0.0 2.2 2 0 0 2 2 2 1 Miro-like protein Gtr1_RagA PF04670.7 KOO34373.1 - 0.00015 20.9 0.0 0.00044 19.4 0.0 1.7 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KOO34373.1 - 0.001 18.5 0.0 0.0035 16.8 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EF-hand_1 PF00036.27 KOO34373.1 - 0.002 17.3 0.0 0.0061 15.7 0.0 1.9 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO34373.1 - 0.0038 16.9 0.1 0.02 14.7 0.0 2.3 2 0 0 2 2 1 1 EF-hand domain EF-hand_8 PF13833.1 KOO34373.1 - 0.0076 15.8 0.0 0.7 9.5 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair DEC-1_N PF04625.8 KOO34373.1 - 0.049 12.3 11.0 0.08 11.6 7.6 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region EF-hand_7 PF13499.1 KOO34373.1 - 0.086 12.9 0.0 0.3 11.2 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain pair Ras PF00071.17 KOO34373.1 - 0.1 12.0 0.1 6.9 6.0 0.0 2.3 2 0 0 2 2 2 0 Ras family AIG1 PF04548.11 KOO34373.1 - 0.11 11.6 0.0 0.65 9.0 0.0 2.0 2 0 0 2 2 2 0 AIG1 family Ank_2 PF12796.2 KOO34374.1 - 1e-10 41.8 0.1 1.6e-09 37.9 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO34374.1 - 1.3e-08 35.0 0.1 9.1e-07 29.2 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO34374.1 - 2.3e-07 30.8 0.3 1.2e-06 28.5 0.2 2.3 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.25 KOO34374.1 - 3.2e-07 29.8 0.1 0.0051 16.5 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 KOO34374.1 - 0.00077 19.4 0.0 0.78 10.1 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeat FKBP_C PF00254.23 KOO34375.1 - 6.9e-29 99.7 0.0 2e-28 98.2 0.0 1.7 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_11 PF13414.1 KOO34375.1 - 3.6e-08 32.9 1.4 2.2e-06 27.2 0.0 4.4 4 1 0 4 4 4 2 TPR repeat TPR_2 PF07719.12 KOO34375.1 - 7.7e-08 31.6 6.6 0.0055 16.5 0.0 5.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO34375.1 - 4.3e-06 26.0 7.0 0.00035 20.0 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat DUF4252 PF14060.1 KOO34375.1 - 0.25 10.8 0.0 0.25 10.8 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4252) Porin_2 PF02530.9 KOO34375.1 - 2.6 7.0 9.8 4.1 6.3 6.8 1.2 1 0 0 1 1 1 0 Porin subfamily Adap_comp_sub PF00928.16 KOO34376.1 - 1.8e-87 292.7 0.0 2.3e-87 292.4 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 KOO34376.1 - 0.016 14.8 0.2 0.046 13.4 0.2 1.8 1 1 0 1 1 1 0 Clathrin adaptor complex small chain ubiquitin PF00240.18 KOO34378.1 - 1.9e-07 30.3 0.4 4.5e-07 29.1 0.2 1.6 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.1 KOO34378.1 - 1.4e-06 28.4 0.1 5.4e-06 26.5 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.3 KOO34378.1 - 0.02 14.5 0.2 0.083 12.5 0.1 1.8 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Arm PF00514.18 KOO34379.1 - 8.4e-32 107.9 18.0 2e-06 27.4 0.1 6.5 6 0 0 6 6 6 6 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 KOO34379.1 - 0.0018 17.4 0.2 0.19 10.7 0.1 2.6 1 1 3 4 4 4 3 Armadillo-like Succ_CoA_lig PF13607.1 KOO34379.1 - 0.043 13.4 18.3 0.81 9.2 0.3 4.4 1 1 3 4 4 4 0 Succinyl-CoA ligase like flavodoxin domain LysM PF01476.15 KOO34379.1 - 0.11 12.4 2.0 19 5.2 0.0 3.4 3 0 0 3 3 3 0 LysM domain CoA_binding_2 PF13380.1 KOO34379.1 - 1.7 8.8 13.6 35 4.5 0.2 4.2 1 1 3 4 4 4 0 CoA binding domain HMG_box PF00505.14 KOO34381.1 - 2e-14 53.6 8.4 3.3e-08 33.6 0.3 4.3 3 1 1 4 4 4 2 HMG (high mobility group) box PWWP PF00855.12 KOO34381.1 - 8.5e-13 48.3 0.0 8.5e-13 48.3 0.0 3.0 3 0 0 3 3 3 1 PWWP domain DDT PF02791.12 KOO34381.1 - 0.00012 21.8 0.1 0.00035 20.2 0.0 1.8 1 0 0 1 1 1 1 DDT domain HMG_box_2 PF09011.5 KOO34381.1 - 0.00013 22.2 0.7 0.00013 22.2 0.5 4.2 2 1 2 4 4 4 2 HMG-box domain WHIM2 PF15613.1 KOO34381.1 - 0.022 14.6 0.0 0.053 13.4 0.0 1.6 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 2 Pox_C4_C10 PF03336.8 KOO34382.1 - 7.9e-06 24.8 0.0 1.2e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Poxvirus C4/C10 protein DUF2304 PF10066.4 KOO34382.1 - 0.025 14.4 1.3 0.078 12.8 0.9 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) 2OG-FeII_Oxy_3 PF13640.1 KOO34382.1 - 0.026 15.0 0.0 0.091 13.2 0.0 2.0 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily GDPD PF03009.12 KOO34384.1 - 0.017 14.6 0.0 0.031 13.7 0.0 1.6 1 1 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family rve PF00665.21 KOO34385.1 - 5.8e-08 32.8 0.0 1.5e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVT_2 PF07727.9 KOO34385.1 - 0.002 17.1 0.0 0.0031 16.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) UQ_con PF00179.21 KOO34386.1 - 1.2e-44 151.1 0.0 2.1e-44 150.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFD1 PF03152.9 KOO34386.1 - 7.6e-17 61.0 0.0 1.2e-16 60.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 UBX PF00789.15 KOO34386.1 - 5.5e-09 35.9 0.0 1.4e-08 34.6 0.0 1.6 1 0 0 1 1 1 1 UBX domain PDZ PF00595.19 KOO34386.1 - 4.2e-08 33.2 0.1 8.5e-08 32.2 0.1 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO34386.1 - 0.011 15.5 0.1 0.023 14.6 0.1 1.5 1 0 0 1 1 1 0 PDZ domain RWD PF05773.17 KOO34386.1 - 0.067 13.0 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 RWD domain OmpH PF03938.9 KOO34386.1 - 0.56 10.1 10.4 0.037 13.9 3.6 1.6 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Borrelia_P83 PF05262.6 KOO34386.1 - 7.5 4.6 11.9 11 4.1 8.2 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein LRR_6 PF13516.1 KOO34387.1 - 1.9e-26 89.1 28.2 0.57 10.4 0.0 17.8 20 0 0 20 20 19 7 Leucine Rich repeat LRR_1 PF00560.28 KOO34387.1 - 2.6e-12 44.9 6.3 7.9 6.9 0.0 12.8 17 0 0 17 17 16 2 Leucine Rich Repeat LRR_4 PF12799.2 KOO34387.1 - 2.5e-10 39.7 11.2 0.021 14.4 0.0 10.0 10 2 3 13 13 13 3 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO34387.1 - 1.3e-05 24.5 14.9 45 4.9 0.0 12.5 16 0 0 16 16 15 0 Leucine rich repeat LRR_8 PF13855.1 KOO34387.1 - 0.00017 21.2 11.8 3 7.6 0.0 9.3 12 1 0 12 12 12 1 Leucine rich repeat FIBP PF05427.6 KOO34387.1 - 0.0014 17.9 0.7 3.7 6.7 0.0 3.8 4 0 0 4 4 4 1 Acidic fibroblast growth factor binding (FIBP) SpoU_sub_bind PF08032.7 KOO34387.1 - 0.0029 17.7 1.4 38 4.5 0.0 5.3 5 1 1 6 6 6 0 RNA 2'-O ribose methyltransferase substrate binding DUF902 PF06001.8 KOO34387.1 - 0.012 15.6 0.2 28 4.9 0.0 3.6 3 0 0 3 3 3 0 Domain of Unknown Function (DUF902) DUF2677 PF10838.3 KOO34387.1 - 0.027 14.1 0.0 7 6.2 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2677) Mg_chelatase_2 PF13335.1 KOO34387.1 - 0.074 13.4 0.3 1.4e+02 2.9 0.0 4.2 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI Toxin_40 PF15520.1 KOO34387.1 - 0.18 11.2 17.6 0.077 12.4 0.2 5.8 4 2 1 6 6 6 0 Putative toxin 40 TraF PF13728.1 KOO34387.1 - 0.26 10.7 0.0 55 3.1 0.0 3.4 4 0 0 4 4 4 0 F plasmid transfer operon protein Pkinase PF00069.20 KOO34388.1 - 1.6e-45 155.3 0.0 2.2e-45 154.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34388.1 - 2.9e-38 131.4 0.0 4e-38 130.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO34388.1 - 0.0012 17.8 0.0 0.0018 17.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO34388.1 - 0.0049 16.6 0.1 0.0093 15.7 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family DNA_topoisoIV PF00521.15 KOO34389.1 - 1.5e-41 142.6 0.0 2.2e-41 142.0 0.0 1.1 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A SAP PF02037.22 KOO34389.1 - 1.5e-12 46.7 0.2 3e-12 45.7 0.1 1.6 1 0 0 1 1 1 1 SAP domain Toprim PF01751.17 KOO34389.1 - 7.9e-10 38.6 0.0 1.5e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Toprim domain DNA_gyraseB PF00204.20 KOO34389.1 - 1.6e-09 37.2 0.0 3.1e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.21 KOO34389.1 - 1.9e-08 34.0 0.0 3.3e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HeH PF12949.2 KOO34389.1 - 0.0066 15.9 0.0 0.016 14.7 0.0 1.7 1 0 0 1 1 1 1 HeH/LEM domain Pkinase PF00069.20 KOO34390.1 - 4.3e-47 160.4 0.0 6.2e-47 159.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34390.1 - 3.4e-39 134.4 0.0 5.1e-39 133.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ribosomal_S28e PF01200.13 KOO34391.1 - 1.4e-31 108.0 0.8 1.5e-31 107.9 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e WD40 PF00400.27 KOO34392.1 - 1.2e-22 78.9 17.2 9.4e-06 25.3 0.5 9.3 10 0 0 10 10 10 8 WD domain, G-beta repeat ENTH PF01417.15 KOO34393.1 - 4.7e-05 23.2 0.0 0.27 11.0 0.0 2.2 2 0 0 2 2 2 2 ENTH domain VHS PF00790.14 KOO34393.1 - 0.0023 17.5 0.0 0.63 9.6 0.0 2.2 2 0 0 2 2 2 2 VHS domain ANTH PF07651.11 KOO34393.1 - 0.0082 14.8 0.1 0.029 13.0 0.0 1.7 2 0 0 2 2 2 1 ANTH domain WD40 PF00400.27 KOO34394.1 - 1.8e-25 87.8 10.8 1.5e-07 31.0 0.0 5.8 5 1 1 6 6 6 4 WD domain, G-beta repeat eIF2A PF08662.6 KOO34394.1 - 0.0048 16.6 0.0 0.045 13.4 0.0 2.2 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A RF-1 PF00472.15 KOO34395.1 - 8.8e-39 131.8 0.9 8.8e-39 131.8 0.6 1.5 2 0 0 2 2 2 1 RF-1 domain PCRF PF03462.13 KOO34395.1 - 2.3e-09 36.9 0.4 4.9e-09 35.8 0.0 1.8 2 0 0 2 2 2 1 PCRF domain cNMP_binding PF00027.24 KOO34397.1 - 0.17 11.6 0.0 0.37 10.6 0.0 1.6 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain zf-RING_2 PF13639.1 KOO34398.1 - 1.5e-11 43.9 9.2 3.9e-11 42.5 6.4 1.8 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 KOO34398.1 - 5.2e-10 39.2 9.4 2e-09 37.4 6.5 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 KOO34398.1 - 1.5e-07 30.9 5.1 1.5e-07 30.9 3.5 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO34398.1 - 9.1e-07 28.4 7.9 1.8e-06 27.4 5.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO34398.1 - 6.1e-06 26.1 8.4 1.3e-05 25.1 5.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO34398.1 - 9.9e-05 21.9 7.3 0.00023 20.7 5.1 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 KOO34398.1 - 0.0013 18.4 3.8 0.002 17.7 2.2 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-Apc11 PF12861.2 KOO34398.1 - 0.0015 18.3 6.1 0.0045 16.7 4.2 1.8 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.1 KOO34398.1 - 0.0021 17.8 5.1 0.0052 16.6 3.5 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.1 KOO34398.1 - 0.0064 16.0 3.4 0.013 15.0 2.4 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 FANCL_C PF11793.3 KOO34398.1 - 0.57 10.1 5.9 2.8 7.9 4.1 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.1 KOO34398.1 - 0.68 9.5 4.7 1.9 8.1 3.2 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Mitoc_L55 PF09776.4 KOO34399.1 - 0.0031 17.0 5.8 3.8 7.1 0.0 5.8 2 1 4 7 7 7 2 Mitochondrial ribosomal protein L55 LRR_5 PF13306.1 KOO34400.1 - 2.8e-68 227.5 0.8 5e-40 136.1 0.1 2.2 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO34400.1 - 1e-19 69.9 0.4 0.00028 20.5 0.0 6.2 2 1 4 6 6 6 5 Leucine rich repeat APC_crr PF05923.7 KOO34400.1 - 0.029 13.9 5.6 0.57 9.8 0.4 4.3 3 0 0 3 3 3 0 APC cysteine-rich region Calmodulin_bind PF07887.6 KOO34400.1 - 0.13 11.2 0.2 35 3.2 0.0 3.4 2 2 2 4 4 4 0 Calmodulin binding protein-like AP2 PF00847.15 KOO34401.1 - 5.6e-05 23.2 1.3 0.00011 22.3 0.0 2.3 2 0 0 2 2 2 1 AP2 domain Sporozoite_P67 PF05642.6 KOO34401.1 - 5.4 4.7 6.9 10 3.8 1.5 2.3 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Piwi PF02171.12 KOO34402.1 - 2.2e-65 220.5 0.0 3.2e-65 220.0 0.0 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.17 KOO34402.1 - 5.3e-12 45.2 0.2 2.3e-10 39.9 0.0 2.6 3 0 0 3 3 3 1 PAZ domain VWA_3 PF13768.1 KOO34402.1 - 0.04 13.6 0.0 0.12 12.0 0.0 1.8 1 0 0 1 1 1 0 von Willebrand factor type A domain DUF3972 PF13118.1 KOO34404.1 - 0.032 14.3 3.7 0.062 13.3 2.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3972) Hex_IIIa PF02455.11 KOO34404.1 - 5 5.6 7.9 9.6 4.7 5.5 1.5 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) DUF16 PF01519.11 KOO34404.1 - 5.6 7.2 6.8 1.9 8.7 2.6 1.7 1 1 1 2 2 2 0 Protein of unknown function DUF16 LRR_5 PF13306.1 KOO34405.1 - 1.1e-222 726.8 9.2 2.2e-46 156.7 0.0 6.0 2 2 4 6 6 6 6 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO34405.1 - 1.2e-42 143.4 0.0 0.00046 19.8 0.0 12.1 2 2 15 17 17 17 15 Leucine rich repeat DUF3620 PF12281.3 KOO34405.1 - 0.00044 20.0 3.4 18 4.9 0.0 6.8 3 3 3 8 8 8 1 Protein of unknown function (DUF3620) LRR_4 PF12799.2 KOO34405.1 - 0.0032 17.0 0.0 5.5 6.7 0.0 3.9 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) PRC PF05239.11 KOO34405.1 - 0.13 12.1 0.0 9.3 6.1 0.0 2.3 2 0 0 2 2 2 0 PRC-barrel domain Antiterm PF03589.8 KOO34405.1 - 6.7 6.8 11.1 1.1e+02 2.9 0.0 6.3 5 3 2 7 7 7 0 Antitermination protein Ank_2 PF12796.2 KOO34407.1 - 2.1e-29 101.7 2.3 2.8e-12 46.7 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO34407.1 - 1.3e-28 98.8 2.7 4.2e-11 43.0 0.0 5.0 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.25 KOO34407.1 - 1.5e-27 94.0 8.1 7.7e-07 28.6 0.0 5.2 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.1 KOO34407.1 - 1.6e-24 85.3 6.8 1e-08 35.1 0.0 4.6 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO34407.1 - 9.8e-24 81.0 1.5 0.00052 20.0 0.0 5.2 5 0 0 5 5 5 5 Ankyrin repeat Ribosomal_S21e PF01249.13 KOO34410.1 - 2.1e-34 117.3 0.0 2.6e-34 116.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S21e LrgB PF04172.11 KOO34411.1 - 5.3e-29 100.9 13.6 1.1e-28 99.9 9.4 1.6 1 1 0 1 1 1 1 LrgB-like family LrgA PF03788.9 KOO34411.1 - 0.27 10.9 19.4 0.4 10.4 2.7 3.6 2 1 1 3 3 3 0 LrgA family Methyltransf_11 PF08241.7 KOO34412.1 - 2.5e-24 85.6 0.0 4.2e-24 84.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO34412.1 - 4.1e-22 78.4 0.0 5.6e-22 77.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO34412.1 - 9.1e-21 74.2 0.0 1.6e-20 73.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO34412.1 - 4.7e-17 62.2 0.0 9.1e-17 61.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO34412.1 - 2.8e-15 56.8 0.0 5.1e-15 56.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 KOO34412.1 - 2e-13 50.0 0.0 2.6e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.13 KOO34412.1 - 2.5e-12 46.3 0.0 4e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 KOO34412.1 - 6.3e-12 45.7 0.0 1.1e-11 45.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO34412.1 - 1e-09 38.3 0.0 2.7e-09 37.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.11 KOO34412.1 - 5.2e-08 31.6 0.0 8.1e-08 31.0 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_4 PF02390.12 KOO34412.1 - 1.2e-07 31.0 0.0 2.8e-05 23.2 0.0 2.3 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.9 KOO34412.1 - 1.1e-06 28.1 0.0 2.6e-06 26.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_PK PF05891.7 KOO34412.1 - 1.2e-05 24.7 0.0 2.1e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase PCMT PF01135.14 KOO34412.1 - 6.6e-05 22.5 0.0 0.0001 21.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) NAS PF03059.11 KOO34412.1 - 6.8e-05 22.1 0.0 9.3e-05 21.7 0.0 1.1 1 0 0 1 1 1 1 Nicotianamine synthase protein Methyltransf_8 PF05148.10 KOO34412.1 - 0.00014 21.5 0.0 0.00038 20.1 0.0 1.7 1 1 0 1 1 1 1 Hypothetical methyltransferase DREV PF05219.7 KOO34412.1 - 0.00033 19.6 0.0 0.00075 18.4 0.0 1.5 2 0 0 2 2 2 1 DREV methyltransferase Methyltransf_32 PF13679.1 KOO34412.1 - 0.0019 17.8 0.0 0.0031 17.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 KOO34412.1 - 0.002 17.5 0.0 0.0031 16.8 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW ADH_zinc_N PF00107.21 KOO34412.1 - 0.0024 17.4 0.0 0.0061 16.1 0.0 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase NodS PF05401.6 KOO34412.1 - 0.0027 17.1 0.0 0.0042 16.4 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_24 PF13578.1 KOO34412.1 - 0.0054 17.5 0.0 0.011 16.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 KOO34412.1 - 0.0071 16.3 0.0 0.021 14.8 0.0 1.7 1 1 0 1 1 1 1 FtsJ-like methyltransferase Shikimate_DH PF01488.15 KOO34412.1 - 0.01 15.9 0.0 0.015 15.3 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TehB PF03848.9 KOO34412.1 - 0.017 14.2 0.0 0.083 12.0 0.0 2.0 3 0 0 3 3 3 0 Tellurite resistance protein TehB Methyltransf_9 PF08003.6 KOO34412.1 - 0.021 13.5 0.0 0.027 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) FmrO PF07091.6 KOO34412.1 - 0.037 13.0 0.0 0.066 12.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) DUF938 PF06080.7 KOO34412.1 - 0.085 12.3 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) EF-hand_1 PF00036.27 KOO34413.1 - 9.7e-10 37.0 0.0 0.0032 16.6 0.0 3.6 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.1 KOO34413.1 - 7.3e-08 31.4 0.1 0.037 13.3 0.0 3.7 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO34413.1 - 1.9e-07 30.3 0.1 0.006 16.3 0.0 3.9 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.1 KOO34413.1 - 4.4e-07 29.4 0.2 0.014 14.9 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.1 KOO34413.1 - 4.7e-07 29.8 0.1 0.025 14.6 0.0 3.4 2 1 0 2 2 2 2 EF-hand domain pair Chromo PF00385.19 KOO34414.1 - 0.0077 15.8 0.0 0.017 14.7 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Daxx PF03344.10 KOO34415.1 - 0.24 9.8 5.4 0.32 9.4 3.7 1.1 1 0 0 1 1 1 0 Daxx Family tRNA-synt_1g PF09334.6 KOO34416.1 - 2.9e-107 358.7 0.0 4.8e-106 354.7 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (M) FH2 PF02181.18 KOO34416.1 - 2.6e-36 125.2 0.0 5.2e-36 124.2 0.0 1.4 1 0 0 1 1 1 1 Formin Homology 2 Domain tRNA_bind PF01588.15 KOO34416.1 - 3e-27 94.2 1.4 2.7e-26 91.2 0.2 2.4 2 0 0 2 2 2 1 Putative tRNA binding domain tRNA-synt_1 PF00133.17 KOO34416.1 - 4e-27 94.4 0.0 1.1e-15 56.7 0.0 3.1 3 0 0 3 3 3 2 tRNA synthetases class I (I, L, M and V) NDK PF00334.14 KOO34416.1 - 7e-19 67.9 0.0 1.4e-18 66.9 0.0 1.4 1 0 0 1 1 1 1 Nucleoside diphosphate kinase tRNA-synt_1e PF01406.14 KOO34416.1 - 1.3e-11 44.1 0.0 9.4e-06 24.9 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.13 KOO34416.1 - 0.0011 17.7 0.0 0.17 10.5 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (K) PABP PF00658.13 KOO34417.1 - 1.1e-08 34.5 0.2 3.5e-08 33.0 0.2 1.8 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RAP1 PF07218.6 KOO34417.1 - 6.8 4.6 6.5 9.8 4.1 4.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) LRR_6 PF13516.1 KOO34420.1 - 1.8e-54 175.6 5.0 0.00069 19.4 0.0 13.4 13 0 0 13 13 13 12 Leucine Rich repeat LRR_4 PF12799.2 KOO34420.1 - 2.2e-05 23.9 13.2 2.2 7.9 0.0 7.4 5 3 3 8 8 8 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO34420.1 - 3.7e-05 23.1 0.0 41 4.7 0.0 7.7 10 0 0 10 10 10 0 Leucine Rich Repeat NACHT PF05729.7 KOO34420.1 - 3.8e-05 23.4 0.1 8.7e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 NACHT domain SpoU_sub_bind PF08032.7 KOO34420.1 - 5.9e-05 23.1 16.1 0.74 10.0 0.0 7.1 4 3 4 8 8 8 2 RNA 2'-O ribose methyltransferase substrate binding LRR_8 PF13855.1 KOO34420.1 - 0.4 10.4 7.9 28 4.5 0.1 5.8 4 2 3 7 7 7 0 Leucine rich repeat LRR_7 PF13504.1 KOO34420.1 - 9.2 6.9 13.3 54 4.6 0.0 7.6 10 0 0 10 10 10 0 Leucine rich repeat EF-hand_1 PF00036.27 KOO34421.1 - 5.2e-11 41.0 2.0 1.8e-05 23.6 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO34421.1 - 1.7e-10 39.7 2.3 0.00015 20.9 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO34421.1 - 2.5e-10 39.3 2.3 0.00012 21.6 0.2 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO34421.1 - 7e-10 38.9 0.6 1e-09 38.4 0.4 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_10 PF14788.1 KOO34421.1 - 1.4e-05 24.6 0.1 0.12 12.0 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO34421.1 - 3.3e-05 23.4 2.3 0.00024 20.6 0.4 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.2 KOO34421.1 - 9.9e-05 22.0 1.2 0.2 11.3 0.1 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.1 KOO34422.1 - 1.3e-16 60.4 4.6 3.7e-11 43.0 0.8 2.0 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO34422.1 - 2.7e-13 48.1 0.6 1.1e-05 24.4 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO34422.1 - 3.9e-12 44.9 0.5 9.5e-05 21.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO34422.1 - 6.2e-11 41.7 0.1 0.0004 19.9 0.0 2.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO34422.1 - 1.5e-10 39.9 1.6 0.00014 21.0 0.2 2.2 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.2 KOO34422.1 - 0.048 13.4 1.4 2.4 7.9 0.1 2.1 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO34422.1 - 0.12 12.0 0.3 4.6 6.9 0.0 2.1 2 0 0 2 2 2 0 EF hand EF-hand_1 PF00036.27 KOO34423.1 - 1.2e-11 43.0 0.9 4.1e-05 22.5 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO34423.1 - 2.4e-10 40.4 0.2 4.4e-10 39.5 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO34423.1 - 1.3e-07 31.0 3.2 1.2e-05 24.7 0.3 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO34423.1 - 4e-07 29.3 0.1 0.00032 20.3 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO34423.1 - 2.6e-05 23.3 0.4 0.0091 15.3 0.0 2.4 2 0 0 2 2 2 2 EF hand PTS_2-RNA PF01885.11 KOO34423.1 - 0.092 12.0 0.0 16 4.7 0.0 2.4 2 0 0 2 2 2 0 RNA 2'-phosphotransferase, Tpt1 / KptA family SPARC_Ca_bdg PF10591.4 KOO34423.1 - 0.096 12.7 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region TrkH PF02386.11 KOO34424.1 - 1.3e-28 99.6 13.4 3.1e-17 62.1 2.0 3.2 3 0 0 3 3 3 3 Cation transport protein CoA_transf_3 PF02515.12 KOO34428.1 - 0.039 13.1 1.2 0.077 12.2 0.8 1.4 1 0 0 1 1 1 0 CoA-transferase family III SET_assoc PF11767.3 KOO34430.1 - 0.043 13.1 0.1 17 4.7 0.0 3.0 3 0 0 3 3 3 0 Histone lysine methyltransferase SET associated Arm PF00514.18 KOO34431.1 - 2.2e-26 90.7 12.7 1e-08 34.6 0.1 5.9 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat U-box PF04564.10 KOO34431.1 - 6.1e-13 48.5 0.0 1.2e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 U-box domain Methyltransf_26 PF13659.1 KOO34431.1 - 8.7e-12 45.1 0.4 8.7e-12 45.1 0.3 2.7 2 0 0 2 2 2 1 Methyltransferase domain UPF0020 PF01170.13 KOO34431.1 - 3.5e-10 39.7 0.4 1.4e-09 37.7 0.0 2.0 2 0 0 2 2 2 1 Putative RNA methylase family UPF0020 zf-Nse PF11789.3 KOO34431.1 - 2e-05 24.0 0.0 3.9e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Methyltransf_11 PF08241.7 KOO34431.1 - 0.00055 20.3 0.0 0.0018 18.7 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Arm_2 PF04826.8 KOO34431.1 - 0.0037 16.4 0.0 0.62 9.1 0.0 2.3 1 1 1 2 2 2 2 Armadillo-like AIP3 PF03915.8 KOO34431.1 - 0.075 11.9 3.7 0.11 11.3 2.5 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 DivIVA PF05103.8 KOO34431.1 - 1.1 9.3 13.4 2.2 8.3 9.3 1.4 1 0 0 1 1 1 0 DivIVA protein PP2C PF00481.16 KOO34432.1 - 2.2e-47 161.6 0.0 2.6e-47 161.3 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 KOO34432.1 - 1.7e-06 27.5 0.0 3.4e-06 26.6 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOO34432.1 - 1.1e-05 25.2 0.3 8.3e-05 22.3 0.2 2.0 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) FdhE PF04216.7 KOO34433.1 - 0.026 14.2 2.3 0.037 13.7 1.6 1.1 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation Octopine_DH PF02317.12 KOO34433.1 - 0.091 12.4 0.6 0.13 11.8 0.4 1.2 1 0 0 1 1 1 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain SHIPPO-rpt PF07004.7 KOO34434.1 - 1e-09 38.7 4.6 0.44 11.5 0.0 5.1 5 0 0 5 5 5 3 Sperm-tail PG-rich repeat ECR1_N PF14382.1 KOO34434.1 - 0.29 10.4 1.9 2.9 7.2 0.3 2.4 2 0 0 2 2 2 0 Exosome complex exonuclease RRP4 N-terminal region Pro_isomerase PF00160.16 KOO34435.1 - 8e-23 81.3 0.0 1.3e-22 80.6 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Orthoreo_P10 PF07204.6 KOO34435.1 - 0.11 12.2 0.1 0.23 11.2 0.1 1.4 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 SBF PF01758.11 KOO34436.1 - 1.8e-12 47.0 6.5 1.8e-12 47.0 4.5 1.9 2 0 0 2 2 2 1 Sodium Bile acid symporter family Mem_trans PF03547.13 KOO34436.1 - 5.4 5.2 8.8 0.19 10.0 0.8 2.3 2 1 1 3 3 3 0 Membrane transport protein GFA PF04828.9 KOO34437.1 - 1.6e-07 31.1 0.5 3.5e-07 30.0 0.3 1.6 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme LRR_6 PF13516.1 KOO34439.1 - 8.6e-18 62.3 24.0 0.00012 21.7 0.0 7.7 8 0 0 8 8 8 5 Leucine Rich repeat LRR_1 PF00560.28 KOO34439.1 - 5.2e-07 28.8 12.9 2.1 8.7 0.1 7.3 7 0 0 7 7 7 3 Leucine Rich Repeat LRR_4 PF12799.2 KOO34439.1 - 7e-06 25.5 21.0 0.0018 17.8 1.5 4.8 3 2 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO34439.1 - 0.023 14.4 22.3 0.037 13.7 5.8 4.1 3 2 0 3 3 3 0 Leucine rich repeat LRR_7 PF13504.1 KOO34439.1 - 2.8 8.5 23.4 9.3 6.9 0.0 7.0 8 0 0 8 8 8 0 Leucine rich repeat NHL PF01436.16 KOO34440.1 - 1e-24 85.1 9.2 0.0002 21.1 0.3 6.4 6 0 0 6 6 6 5 NHL repeat PQQ_3 PF13570.1 KOO34440.1 - 2.1e-06 27.7 3.9 0.26 11.6 0.0 4.6 5 0 0 5 5 5 2 PQQ-like domain SGL PF08450.7 KOO34440.1 - 0.00053 19.4 0.0 0.048 13.0 0.0 2.8 2 2 0 2 2 2 1 SMP-30/Gluconolaconase/LRE-like region DUF3456 PF11938.3 KOO34441.1 - 9.4e-24 84.1 0.0 1.7e-23 83.2 0.0 1.4 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP ABC_tran PF00005.22 KOO34443.1 - 1.9e-11 44.4 0.0 3e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.1 KOO34443.1 - 0.0011 19.1 0.0 0.0031 17.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain DUF1330 PF07045.6 KOO34443.1 - 0.0055 16.5 0.0 0.01 15.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1330) SbcCD_C PF13558.1 KOO34443.1 - 0.0086 15.9 0.0 0.066 13.1 0.0 2.3 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.1 KOO34443.1 - 0.06 12.7 0.1 0.11 11.8 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.1 KOO34443.1 - 0.23 11.4 0.6 3.8 7.4 0.1 2.0 1 1 0 2 2 2 0 AAA domain Filament PF00038.16 KOO34444.1 - 8.4 5.7 55.9 11 5.4 26.4 2.7 1 1 1 2 2 2 0 Intermediate filament protein PP2C PF00481.16 KOO34445.1 - 2.3e-16 59.9 0.0 3.7e-13 49.4 0.0 2.0 1 1 1 2 2 2 2 Protein phosphatase 2C EF-hand_7 PF13499.1 KOO34447.1 - 8.8e-12 44.9 0.2 1.3e-11 44.4 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO34447.1 - 4e-10 38.2 1.3 2.2e-05 23.4 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO34447.1 - 6.3e-06 25.6 0.4 0.18 11.7 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO34447.1 - 1.7e-05 24.3 2.3 0.083 12.5 0.4 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO34447.1 - 0.00046 19.4 1.4 0.053 12.8 0.0 2.6 2 0 0 2 2 2 1 EF hand EF-hand_9 PF14658.1 KOO34447.1 - 0.00062 19.6 0.0 0.0011 18.8 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO34447.1 - 0.035 14.1 0.0 0.061 13.3 0.0 1.4 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO34447.1 - 0.09 12.5 0.1 0.2 11.4 0.1 1.5 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO34447.1 - 0.12 12.0 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 EF hand Rhodanese PF00581.15 KOO34448.1 - 3.4e-08 33.8 0.0 4.2e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain NAD_binding_1 PF00175.16 KOO34449.1 - 1.6e-25 89.8 0.0 2.5e-25 89.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 KOO34449.1 - 1.6e-05 24.9 0.0 2.8e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain FAD_binding_1 PF00667.15 KOO34449.1 - 0.001 18.5 0.0 1 8.7 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain DBR1 PF05011.8 KOO34449.1 - 0.0068 16.3 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain DEAD PF00270.24 KOO34450.1 - 8.3e-34 116.5 0.0 1.4e-33 115.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO34450.1 - 2.2e-19 69.1 0.1 5.4e-19 67.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO34450.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Pkinase PF00069.20 KOO34454.1 - 7.6e-41 139.9 0.0 1.3e-40 139.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34454.1 - 9.6e-37 126.4 0.0 4.2e-36 124.3 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase DUF4448 PF14610.1 KOO34454.1 - 0.0035 16.8 0.0 0.01 15.3 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Peptidase_S46 PF10459.4 KOO34455.1 - 3.4 5.9 15.5 4.1 5.7 10.8 1.0 1 0 0 1 1 1 0 Peptidase S46 Phage_int_SAM_5 PF13102.1 KOO34455.1 - 5.2 7.0 10.1 7.8 6.4 6.9 1.6 1 1 0 1 1 1 0 Phage integrase SAM-like domain DUF2229 PF09989.4 KOO34455.1 - 9.2 5.6 8.3 22 4.4 5.3 1.9 1 1 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) DUF1680 PF07944.7 KOO34456.1 - 5.9e-58 196.4 0.0 9e-58 195.8 0.0 1.3 1 0 0 1 1 1 1 Putative glycosyl hydrolase of unknown function (DUF1680) GLTP PF08718.6 KOO34457.1 - 6.9e-29 100.8 0.0 9.1e-29 100.4 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) DUF2810 PF10928.3 KOO34457.1 - 0.016 14.9 0.2 0.41 10.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2810) DUF1275 PF06912.6 KOO34458.1 - 2.6e-16 59.4 5.6 4.3e-16 58.7 3.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) PDZ PF00595.19 KOO34458.1 - 0.00014 21.9 0.0 0.00025 21.1 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) CRM1_C PF08767.6 KOO34459.1 - 0.047 12.5 0.0 0.061 12.2 0.0 1.1 1 0 0 1 1 1 0 CRM1 C terminal Sel1 PF08238.7 KOO34459.1 - 0.21 12.3 2.3 1.9 9.2 0.1 2.7 2 0 0 2 2 2 0 Sel1 repeat Acyl-CoA_dh_1 PF00441.19 KOO34459.1 - 0.68 10.0 4.6 1.3 9.0 3.2 1.5 1 1 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain IBN_N PF03810.14 KOO34464.1 - 0.0092 15.8 0.2 0.99 9.3 0.0 2.3 1 1 1 2 2 2 2 Importin-beta N-terminal domain Ank PF00023.25 KOO34465.1 - 0.36 10.7 2.2 9.8 6.1 0.0 3.5 4 0 0 4 4 4 0 Ankyrin repeat Ank_2 PF12796.2 KOO34467.1 - 1.3e-21 76.7 2.6 4.5e-10 39.7 0.2 3.3 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO34467.1 - 3e-15 56.2 0.2 3.5e-06 27.3 0.0 3.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO34467.1 - 1e-14 53.4 0.3 2.2e-07 30.3 0.0 4.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 KOO34467.1 - 2.8e-14 52.8 0.3 1.9e-05 24.7 0.1 5.2 4 1 0 4 4 4 3 Ankyrin repeats (many copies) EF-hand_1 PF00036.27 KOO34467.1 - 9.6e-10 37.0 2.2 0.00028 19.9 0.1 3.0 2 0 0 2 2 2 2 EF hand Ank_3 PF13606.1 KOO34467.1 - 1.4e-09 37.2 0.3 0.00089 19.2 0.0 4.6 4 1 0 4 4 4 2 Ankyrin repeat EF-hand_7 PF13499.1 KOO34467.1 - 3.7e-07 30.1 0.7 9.7e-07 28.8 0.5 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO34467.1 - 0.0037 17.0 0.1 0.92 9.5 0.0 2.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.2 KOO34467.1 - 0.011 15.4 0.2 0.031 14.0 0.1 1.7 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand EF-hand_8 PF13833.1 KOO34467.1 - 0.017 14.7 7.2 0.044 13.3 0.7 2.9 2 1 1 3 3 3 0 EF-hand domain pair PPR_3 PF13812.1 KOO34467.1 - 0.036 14.3 0.1 0.79 10.1 0.0 2.8 2 0 0 2 2 2 0 Pentatricopeptide repeat domain Inhibitor_I34 PF10466.4 KOO34467.1 - 0.043 13.8 0.3 7.1 6.7 0.0 3.6 3 1 1 4 4 4 0 Saccharopepsin inhibitor I34 DUF964 PF06133.6 KOO34468.1 - 0.12 12.3 0.3 1.3 9.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF964) Pkinase PF00069.20 KOO34469.1 - 2.7e-35 121.7 0.0 3.8e-35 121.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34469.1 - 3.8e-32 111.3 0.0 5.4e-32 110.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO34469.1 - 0.0012 17.8 0.0 0.0019 17.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO34469.1 - 0.0024 17.6 0.9 0.012 15.3 0.4 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Cellulase-like PF12876.2 KOO34469.1 - 0.026 14.9 0.0 0.071 13.5 0.0 1.7 1 0 0 1 1 1 0 Sugar-binding cellulase-like ADIP PF11559.3 KOO34470.1 - 0.00023 21.1 7.4 0.00023 21.1 5.1 2.1 1 1 1 2 2 2 1 Afadin- and alpha -actinin-Binding FliD_N PF02465.13 KOO34470.1 - 0.045 14.1 3.9 0.1 12.9 2.7 1.6 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus Tropomyosin PF00261.15 KOO34470.1 - 0.19 10.7 24.3 0.01 14.9 12.6 2.0 2 0 0 2 2 2 0 Tropomyosin Sipho_Gp157 PF05565.6 KOO34470.1 - 0.23 11.0 5.9 0.79 9.2 4.2 1.8 1 1 0 1 1 1 0 Siphovirus Gp157 Striatin PF08232.7 KOO34470.1 - 1.1 9.5 18.9 4.7 7.5 2.3 3.3 1 1 1 3 3 3 0 Striatin family HTH_1 PF00126.22 KOO34470.1 - 1.9 8.2 13.7 1.6 8.5 0.2 4.4 3 1 0 3 3 3 0 Bacterial regulatory helix-turn-helix protein, lysR family APG6 PF04111.7 KOO34470.1 - 3 6.8 13.3 0.3 10.0 5.8 1.8 2 0 0 2 2 2 0 Autophagy protein Apg6 GAS PF13851.1 KOO34470.1 - 3.7 6.7 14.4 6 6.0 1.0 3.0 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Kinesin PF00225.18 KOO34471.1 - 1.1e-102 343.1 0.0 1.1e-102 343.1 0.0 1.8 2 0 0 2 2 2 1 Kinesin motor domain ERM PF00769.14 KOO34473.1 - 0.35 10.3 6.0 0.4 10.1 4.2 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Atg14 PF10186.4 KOO34473.1 - 0.46 9.3 6.7 0.58 9.0 4.6 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 EF-hand_7 PF13499.1 KOO34474.1 - 3.9e-22 78.1 0.0 1.1e-13 51.1 0.0 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO34474.1 - 4.9e-22 75.5 0.2 2.5e-05 23.2 0.0 4.8 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.1 KOO34474.1 - 3.3e-20 70.1 0.1 7.5e-05 22.2 0.0 5.0 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.1 KOO34474.1 - 1e-11 43.5 2.3 0.0074 15.5 0.0 4.6 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.1 KOO34474.1 - 8.5e-11 41.3 4.8 0.0038 16.8 0.0 4.6 3 2 2 5 5 5 4 EF-hand domain pair EF-hand_9 PF14658.1 KOO34474.1 - 0.0057 16.5 0.0 2.7 7.9 0.0 2.8 2 1 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO34474.1 - 0.058 13.4 0.0 5.9 6.9 0.0 2.5 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Hemerythrin PF01814.18 KOO34474.1 - 0.079 13.1 0.2 0.19 11.8 0.1 1.7 1 0 0 1 1 1 0 Hemerythrin HHE cation binding domain ICAT PF06384.6 KOO34474.1 - 0.1 12.4 0.1 0.33 10.7 0.0 1.9 2 0 0 2 2 2 0 Beta-catenin-interacting protein ICAT Kinesin PF00225.18 KOO34475.1 - 6.9e-92 307.6 0.0 2e-91 306.1 0.0 1.9 1 1 0 1 1 1 1 Kinesin motor domain Abhydrolase_6 PF12697.2 KOO34479.1 - 3.2e-17 63.1 0.4 4.1e-17 62.8 0.3 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 KOO34479.1 - 9.1e-11 41.4 0.3 1.6e-10 40.7 0.1 1.5 2 0 0 2 2 2 1 Putative lysophospholipase Abhydrolase_5 PF12695.2 KOO34479.1 - 2e-08 34.1 0.1 2.5e-08 33.7 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 KOO34479.1 - 0.0035 16.2 0.5 0.0086 14.9 0.3 1.5 1 1 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_1 PF00561.15 KOO34479.1 - 0.088 12.3 0.0 0.15 11.6 0.0 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold EF-hand_1 PF00036.27 KOO34480.1 - 1.1e-07 30.6 0.1 0.00044 19.3 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO34480.1 - 1.2e-07 31.7 0.1 2.4e-07 30.7 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO34480.1 - 3.8e-07 29.6 0.2 0.026 14.1 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO34480.1 - 8.4e-06 24.8 0.5 0.00058 19.0 0.3 2.6 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO34480.1 - 2.1e-05 23.9 0.2 0.0037 17.0 0.1 2.7 2 0 0 2 2 2 1 EF-hand domain VWA_2 PF13519.1 KOO34481.1 - 1.8e-05 24.8 0.0 0.00011 22.3 0.0 1.9 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 KOO34481.1 - 0.00047 19.9 0.0 0.0049 16.6 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain OKR_DC_1_N PF03709.10 KOO34481.1 - 0.012 15.7 0.0 0.022 14.8 0.0 1.3 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain Exo_endo_phos PF03372.18 KOO34482.1 - 0.00021 21.3 0.0 0.00031 20.7 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF2605 PF10792.4 KOO34482.1 - 0.056 13.1 1.7 0.15 11.7 1.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2605) ADIP PF11559.3 KOO34482.1 - 0.23 11.3 3.9 0.33 10.8 2.7 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF3584 PF12128.3 KOO34482.1 - 0.42 7.8 7.3 0.4 7.9 4.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) HlyD PF00529.15 KOO34482.1 - 2.8 7.1 17.7 4.9 6.3 12.2 1.4 1 0 0 1 1 1 0 HlyD family secretion protein Ank_2 PF12796.2 KOO34484.1 - 1.5e-82 272.0 24.3 1e-21 77.0 0.4 4.5 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.25 KOO34484.1 - 4.3e-59 193.5 17.2 3.6e-07 29.6 0.3 10.0 10 0 0 10 10 10 10 Ankyrin repeat Ank_4 PF13637.1 KOO34484.1 - 1e-55 185.1 6.4 6.9e-10 39.1 0.0 6.4 3 1 5 8 8 8 8 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO34484.1 - 4.4e-40 134.8 16.0 2.8e-08 33.7 0.0 8.8 1 1 8 9 9 9 9 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO34484.1 - 1.9e-37 123.5 8.2 2.5e-05 24.1 0.0 9.9 10 0 0 10 10 10 6 Ankyrin repeat Robl_LC7 PF03259.12 KOO34484.1 - 0.017 14.6 0.0 20 4.8 0.0 3.8 2 1 2 4 4 4 0 Roadblock/LC7 domain Y_phosphatase PF00102.22 KOO34484.1 - 0.12 11.6 0.3 5.9 6.1 0.0 3.3 2 2 1 3 3 3 0 Protein-tyrosine phosphatase Yip1 PF04893.12 KOO34485.1 - 4.3e-13 49.1 9.3 5.8e-13 48.7 6.4 1.1 1 0 0 1 1 1 1 Yip1 domain TcpE PF12648.2 KOO34485.1 - 0.37 10.9 2.7 0.44 10.7 0.9 1.8 1 1 0 1 1 1 0 TcpE family DUF2360 PF10152.4 KOO34489.1 - 9.2 6.5 6.9 2 8.6 1.0 2.2 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein (DUF2360) Chromo PF00385.19 KOO34490.1 - 1.6e-14 53.3 1.8 3e-14 52.4 1.3 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain SH3_3 PF08239.6 KOO34490.1 - 0.00059 19.9 0.1 0.002 18.2 0.0 2.0 2 0 0 2 2 2 1 Bacterial SH3 domain ADPrib_exo_Tox PF03496.9 KOO34491.1 - 6.5e-05 22.2 0.0 0.031 13.4 0.0 2.7 3 0 0 3 3 3 2 ADP-ribosyltransferase exoenzyme ART PF01129.13 KOO34491.1 - 0.0026 16.8 0.0 0.011 14.8 0.0 1.8 1 1 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase DUF1152 PF06626.7 KOO34492.1 - 0.0019 17.3 0.2 1.2 8.2 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1152) F-box PF00646.28 KOO34493.1 - 3.9e-05 23.1 0.5 6.6e-05 22.4 0.0 1.6 2 0 0 2 2 2 1 F-box domain SAP PF02037.22 KOO34494.1 - 5.9e-06 25.6 0.4 1.3e-05 24.5 0.3 1.6 1 0 0 1 1 1 1 SAP domain SHIPPO-rpt PF07004.7 KOO34496.1 - 0.0007 20.3 16.7 5 8.1 0.1 5.8 5 2 0 5 5 5 3 Sperm-tail PG-rich repeat Phage_gp49_66 PF13876.1 KOO34496.1 - 0.091 12.8 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Phage protein (N4 Gp49/phage Sf6 gene 66) family Methyltransf_3 PF01596.12 KOO34497.1 - 2.7e-63 212.7 0.0 1.1e-39 135.6 0.0 2.2 2 0 0 2 2 2 2 O-methyltransferase Methyltransf_24 PF13578.1 KOO34497.1 - 1.4e-29 103.0 1.7 5.7e-15 56.0 0.0 3.0 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_18 PF12847.2 KOO34497.1 - 1.1e-19 71.1 1.0 1.5e-08 35.1 0.1 2.6 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_26 PF13659.1 KOO34497.1 - 3.4e-19 69.0 12.3 7.6e-10 38.8 1.0 3.2 3 1 0 3 3 3 2 Methyltransferase domain PCMT PF01135.14 KOO34497.1 - 6.4e-16 58.5 0.0 3.1e-07 30.1 0.0 2.3 2 0 0 2 2 2 2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 KOO34497.1 - 2.9e-13 49.6 0.0 2.3e-06 27.2 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain MTS PF05175.9 KOO34497.1 - 3.1e-11 42.9 0.1 0.00014 21.2 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase small domain Methyltransf_12 PF08242.7 KOO34497.1 - 1.1e-06 28.9 0.0 0.0033 17.8 0.0 3.0 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_23 PF13489.1 KOO34497.1 - 2.4e-06 27.3 0.2 0.00068 19.3 0.0 2.7 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO34497.1 - 3.5e-05 24.2 0.3 0.02 15.3 0.0 2.9 3 0 0 3 3 3 1 Methyltransferase domain GCD14 PF08704.5 KOO34497.1 - 4.9e-05 22.9 0.0 0.29 10.6 0.0 2.2 2 0 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit Cons_hypoth95 PF03602.10 KOO34497.1 - 0.00033 20.0 0.0 0.046 13.0 0.0 2.3 2 0 0 2 2 2 1 Conserved hypothetical protein 95 DUF633 PF04816.7 KOO34497.1 - 0.11 11.8 0.0 12 5.1 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF633) Cep57_CLD_2 PF14197.1 KOO34497.1 - 8.5 6.3 7.5 24 4.9 0.3 2.8 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 Thioredoxin PF00085.15 KOO34498.1 - 2.7e-14 52.7 0.0 6e-14 51.5 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Acetyltransf_1 PF00583.19 KOO34498.1 - 2e-11 43.7 0.0 4.5e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Thioredoxin_8 PF13905.1 KOO34498.1 - 2.2e-07 30.8 0.0 2.2e-05 24.5 0.0 2.4 1 1 1 2 2 2 1 Thioredoxin-like FR47 PF08445.5 KOO34498.1 - 7.8e-07 28.7 0.0 2e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Thioredoxin_7 PF13899.1 KOO34498.1 - 1.7e-05 24.7 0.0 4.4e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like Acetyltransf_7 PF13508.1 KOO34498.1 - 5.8e-05 23.1 0.0 0.00022 21.3 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Thioredoxin_2 PF13098.1 KOO34498.1 - 8.7e-05 22.6 0.0 0.00025 21.2 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Acetyltransf_9 PF13527.1 KOO34498.1 - 0.00014 21.7 0.1 0.00034 20.4 0.1 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 KOO34498.1 - 0.00027 21.0 0.0 0.00067 19.7 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain TraF PF13728.1 KOO34498.1 - 0.088 12.2 0.1 0.31 10.5 0.0 1.9 2 0 0 2 2 2 0 F plasmid transfer operon protein Thioredoxin_4 PF13462.1 KOO34498.1 - 0.18 11.8 0.1 0.55 10.2 0.0 1.8 2 0 0 2 2 2 0 Thioredoxin Zein-binding PF04576.10 KOO34498.1 - 7.5 6.7 15.2 12 6.1 7.0 2.6 2 0 0 2 2 2 0 Zein-binding PEARLI-4 PF05278.7 KOO34499.1 - 0.052 12.9 0.0 0.072 12.4 0.0 1.1 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) Exostosin PF03016.10 KOO34501.1 - 1.8e-19 69.9 0.0 2.2e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 Exostosin family TBCA PF02970.11 KOO34502.1 - 1.3e-14 53.9 4.7 1.8e-14 53.5 3.3 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor A Pkinase PF00069.20 KOO34503.1 - 1e-26 93.6 0.0 2e-26 92.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain PARP PF00644.15 KOO34503.1 - 4.9e-15 55.5 0.0 1.1e-14 54.4 0.0 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Pkinase_Tyr PF07714.12 KOO34503.1 - 1.9e-12 46.7 0.0 3.8e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO34503.1 - 1.4e-05 24.2 0.0 3.9e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Ham1p_like PF01725.11 KOO34504.1 - 7e-47 159.2 0.0 8e-47 159.0 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Ank_2 PF12796.2 KOO34505.1 - 8.7e-24 83.6 0.1 6.2e-12 45.6 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO34505.1 - 1e-20 73.2 2.2 3.3e-10 39.8 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO34505.1 - 2.8e-18 64.7 0.0 5.9e-09 35.2 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOO34505.1 - 2.7e-15 56.3 7.1 1.8e-05 25.0 0.2 3.8 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO34505.1 - 4.1e-12 45.1 0.1 0.00017 21.4 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Helitron_like_N PF14214.1 KOO34506.1 - 0.12 12.1 0.1 0.59 9.8 0.0 2.2 2 1 0 2 2 2 0 Helitron helicase-like domain at N-terminus PB1 PF00564.19 KOO34507.1 - 0.08 12.6 0.0 0.46 10.1 0.0 1.9 2 0 0 2 2 2 0 PB1 domain FH2 PF02181.18 KOO34508.1 - 3.4e-60 203.8 0.0 4.8e-60 203.4 0.0 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain Glyco_hydro_7 PF00840.15 KOO34509.1 - 4e-152 506.5 12.3 6.4e-152 505.8 8.6 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 GTP_EFTU PF00009.22 KOO34509.1 - 2e-52 177.3 0.1 4.3e-52 176.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.7 KOO34509.1 - 3e-44 149.3 0.5 3e-44 149.3 0.3 2.7 2 0 0 2 2 2 1 GTP-binding protein LepA C-terminus EFG_C PF00679.19 KOO34509.1 - 1e-20 73.3 0.0 8.6e-20 70.4 0.0 2.4 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 KOO34509.1 - 4.2e-09 36.3 4.1 9.7e-09 35.2 2.8 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.1 KOO34509.1 - 0.00014 21.6 0.0 0.0004 20.1 0.0 1.8 1 1 0 1 1 1 1 Elongation Factor G, domain II AhpC-TSA PF00578.16 KOO34509.1 - 0.0079 15.8 0.0 0.058 13.0 0.0 2.2 2 0 0 2 2 2 1 AhpC/TSA family Asp-B-Hydro_N PF05279.6 KOO34509.1 - 0.21 11.4 17.5 0.43 10.3 12.1 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region P16-Arc PF04699.9 KOO34509.1 - 8.2 6.4 11.0 1.5 8.7 4.7 1.9 1 1 0 1 1 1 0 ARP2/3 complex 16 kDa subunit (p16-Arc) SNF2_N PF00176.18 KOO34510.1 - 1.2e-46 158.9 0.0 2.7e-46 157.7 0.0 1.5 2 0 0 2 2 2 1 SNF2 family N-terminal domain zf-C3HC4_2 PF13923.1 KOO34510.1 - 4.9e-07 29.6 9.0 4.9e-07 29.6 6.2 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO34510.1 - 2.2e-06 27.2 8.2 2.2e-06 27.2 5.7 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.24 KOO34510.1 - 5.9e-06 25.8 10.6 5.9e-06 25.8 7.3 3.6 3 0 0 3 3 3 1 PHD-finger zf-C3HC4 PF00097.20 KOO34510.1 - 3e-05 23.5 7.4 3e-05 23.5 5.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO34510.1 - 3.9e-05 23.2 8.2 3.9e-05 23.2 5.7 3.5 3 1 0 3 3 3 1 zinc-RING finger domain Helicase_C PF00271.26 KOO34510.1 - 0.0019 17.9 1.1 0.0024 17.7 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-RING_4 PF14570.1 KOO34510.1 - 0.0029 17.1 7.0 0.0029 17.1 4.8 2.8 3 0 0 3 3 3 1 RING/Ubox like zinc-binding domain DUF1423 PF07227.6 KOO34510.1 - 2 6.9 6.9 3.7 6.1 4.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1423) TauE PF01925.14 KOO34511.1 - 9e-20 71.1 23.8 0.23 10.8 2.1 1.9 1 1 0 1 1 1 1 Sulfite exporter TauE/SafE Acyl_transf_3 PF01757.17 KOO34513.1 - 1.7e-15 56.7 37.6 2e-14 53.2 26.1 2.2 1 1 0 1 1 1 1 Acyltransferase family NHL PF01436.16 KOO34515.1 - 8.4e-26 88.5 8.8 1.8e-08 33.9 0.0 6.2 6 0 0 6 6 6 5 NHL repeat Transglut_core PF01841.14 KOO34515.1 - 3.1e-07 30.6 0.0 6.6e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily SGL PF08450.7 KOO34515.1 - 0.027 13.8 0.0 0.73 9.1 0.0 2.7 3 1 0 3 3 3 0 SMP-30/Gluconolaconase/LRE-like region PQQ_3 PF13570.1 KOO34515.1 - 0.056 13.7 4.0 4.6 7.6 0.0 4.2 5 0 0 5 5 5 0 PQQ-like domain Acetyltransf_1 PF00583.19 KOO34516.1 - 0.0037 17.2 0.1 0.0084 16.1 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Rubella_Capsid PF05750.6 KOO34517.1 - 0.057 12.7 0.7 0.83 8.9 0.0 2.0 2 0 0 2 2 2 0 Rubella capsid protein Tbf5 PF06331.7 KOO34518.1 - 3.9e-11 42.5 0.1 4.8e-11 42.2 0.1 1.1 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 INO80_Ies4 PF08193.6 KOO34518.1 - 0.068 13.0 0.1 0.068 13.0 0.1 1.1 1 0 0 1 1 1 0 INO80 complex subunit Ies4 G-patch_2 PF12656.2 KOO34519.1 - 1.2e-16 60.3 0.1 3.5e-16 58.8 0.1 1.8 1 0 0 1 1 1 1 DExH-box splicing factor binding site KOW PF00467.24 KOO34519.1 - 0.0041 16.7 0.0 1.1 9.0 0.0 2.8 2 0 0 2 2 2 2 KOW motif Cnd2 PF05786.9 KOO34520.1 - 0.12 10.8 0.5 0.16 10.4 0.4 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 Brevenin PF03032.10 KOO34520.1 - 0.65 9.8 2.6 1.1 9.0 1.8 1.3 1 0 0 1 1 1 0 Brevenin/esculentin/gaegurin/rugosin family VCBS PF13517.1 KOO34521.1 - 0.00034 20.9 0.7 0.016 15.5 0.2 2.8 2 0 0 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella PSI PF01437.20 KOO34521.1 - 0.04 14.0 26.2 0.042 13.9 6.8 3.4 3 0 0 3 3 3 0 Plexin repeat Methyltransf_16 PF10294.4 KOO34522.1 - 1.4e-17 63.6 0.0 6.7e-14 51.7 0.0 2.3 2 0 0 2 2 2 2 Putative methyltransferase Methyltransf_23 PF13489.1 KOO34522.1 - 2.7e-06 27.1 0.0 0.004 16.8 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_18 PF12847.2 KOO34522.1 - 0.00015 22.3 0.4 0.0012 19.3 0.1 2.3 2 0 0 2 2 2 1 Methyltransferase domain DUF4573 PF15140.1 KOO34522.1 - 0.0029 17.2 0.1 0.005 16.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4573) Methyltransf_12 PF08242.7 KOO34522.1 - 0.0035 17.7 0.1 2.1 8.8 0.0 3.3 3 1 0 3 3 3 1 Methyltransferase domain HEAT_PBS PF03130.11 KOO34522.1 - 0.044 14.2 2.5 4.8 7.9 0.1 4.6 2 1 1 3 3 3 0 PBS lyase HEAT-like repeat Methyltransf_25 PF13649.1 KOO34522.1 - 0.071 13.4 0.1 0.22 11.9 0.1 1.9 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_26 PF13659.1 KOO34522.1 - 0.088 12.8 6.7 9.9 6.2 5.3 3.4 2 1 0 2 2 2 0 Methyltransferase domain Abhydrolase_2 PF02230.11 KOO34523.1 - 1.9e-26 92.8 0.0 3.9e-26 91.8 0.0 1.4 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.2 KOO34523.1 - 2.3e-08 34.2 2.2 1.2e-07 31.8 0.4 2.1 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO34523.1 - 6.3e-08 32.4 0.4 8.9e-08 32.0 0.3 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 KOO34523.1 - 2.3e-07 30.2 0.1 3.6e-05 23.0 0.1 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.8 KOO34523.1 - 0.00013 21.6 1.0 0.061 12.8 0.2 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.13 KOO34523.1 - 0.0013 18.0 0.1 0.0018 17.5 0.1 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.8 KOO34523.1 - 0.0058 16.0 0.0 0.0075 15.7 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) PE-PPE PF08237.6 KOO34523.1 - 0.01 15.2 0.0 0.02 14.3 0.0 1.4 1 0 0 1 1 1 0 PE-PPE domain Cutinase PF01083.17 KOO34523.1 - 0.024 14.3 0.2 0.078 12.7 0.1 1.8 1 1 1 2 2 2 0 Cutinase EF-hand_7 PF13499.1 KOO34524.1 - 2.3e-10 40.4 0.5 5.9e-10 39.1 0.3 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO34524.1 - 1.3e-06 27.7 0.8 0.0045 16.7 0.0 3.2 2 1 1 3 3 3 2 EF-hand domain EF-hand_1 PF00036.27 KOO34524.1 - 5.1e-06 25.4 3.0 0.0055 15.9 0.0 4.0 3 1 1 4 4 4 2 EF hand EF-hand_8 PF13833.1 KOO34524.1 - 0.00015 21.3 1.2 0.0017 17.9 0.1 3.1 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_9 PF14658.1 KOO34524.1 - 0.00019 21.2 0.0 0.00031 20.6 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain PRESAN PF09687.5 KOO34524.1 - 0.014 15.4 0.0 0.025 14.6 0.0 1.4 1 0 0 1 1 1 0 Plasmodium RESA N-terminal UPF0154 PF03672.8 KOO34524.1 - 0.026 14.1 0.0 0.064 12.8 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) CobN-Mg_chel PF02514.11 KOO34524.1 - 0.027 11.8 0.0 0.03 11.7 0.0 1.0 1 0 0 1 1 1 0 CobN/Magnesium Chelatase EF-hand_5 PF13202.1 KOO34524.1 - 0.11 11.9 5.7 6.2 6.3 0.0 3.8 4 0 0 4 4 4 0 EF hand Mg_trans_NIPA PF05653.9 KOO34525.1 - 6.1e-23 81.2 11.8 8.5e-23 80.7 8.2 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA BRO1 PF03097.13 KOO34526.1 - 1.3e-51 175.5 0.7 1.7e-51 175.1 0.5 1.1 1 0 0 1 1 1 1 BRO1-like domain UBA PF00627.26 KOO34526.1 - 3.2e-06 26.8 0.3 3.2e-06 26.8 0.2 2.2 2 0 0 2 2 2 1 UBA/TS-N domain IQ PF00612.22 KOO34527.1 - 0.00017 20.8 0.0 0.00048 19.5 0.0 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif RVT_2 PF07727.9 KOO34528.1 - 7.1e-12 44.8 0.0 1.1e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TonB_C PF03544.9 KOO34528.1 - 0.083 13.0 0.0 0.57 10.4 0.0 2.3 2 0 0 2 2 2 0 Gram-negative bacterial TonB protein C-terminal Arm PF00514.18 KOO34529.1 - 1.8e-44 148.0 31.3 9.9e-08 31.5 0.1 10.4 9 1 1 10 10 10 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO34529.1 - 2.3e-13 50.2 41.0 2e-06 27.9 4.9 6.1 1 1 7 8 8 8 6 HEAT repeats V-ATPase_H_N PF03224.9 KOO34529.1 - 2.7e-07 30.0 0.0 0.0034 16.5 0.0 2.6 2 1 1 3 3 3 2 V-ATPase subunit H DUF3518 PF12031.3 KOO34529.1 - 0.00038 19.3 0.1 0.44 9.3 0.0 3.1 3 0 0 3 3 3 2 Domain of unknown function (DUF3518) Neurochondrin PF05536.6 KOO34529.1 - 0.00069 18.0 0.1 0.26 9.5 0.0 3.2 3 1 0 3 3 3 1 Neurochondrin HEAT PF02985.17 KOO34529.1 - 0.0088 16.0 12.8 25 5.2 0.0 8.4 9 0 0 9 9 9 0 HEAT repeat Atx10homo_assoc PF09759.4 KOO34529.1 - 0.17 11.6 0.0 4.9 6.9 0.0 2.8 2 1 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain DUF1011 PF06237.7 KOO34529.1 - 0.44 10.4 2.9 0.6 10.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1011) HEAT_EZ PF13513.1 KOO34529.1 - 0.63 10.6 49.4 0.093 13.2 2.0 8.4 4 3 4 8 8 8 0 HEAT-like repeat TPR_10 PF13374.1 KOO34531.1 - 6.5e-75 245.1 30.9 2.2e-11 43.2 0.1 7.7 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_12 PF13424.1 KOO34531.1 - 1.9e-67 223.1 22.5 2.6e-17 62.4 2.3 4.8 3 1 2 5 5 5 5 Tetratricopeptide repeat TPR_11 PF13414.1 KOO34531.1 - 6.5e-25 86.5 14.2 9.1e-07 28.4 0.0 4.7 2 1 3 5 5 5 5 TPR repeat TPR_1 PF00515.23 KOO34531.1 - 4.6e-24 82.9 0.7 0.0043 16.5 0.0 7.3 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.1 KOO34531.1 - 5.9e-18 63.1 14.3 0.011 15.5 0.2 7.4 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_16 PF13432.1 KOO34531.1 - 8.4e-17 61.3 5.8 0.0073 16.9 0.0 5.7 2 1 4 6 6 6 6 Tetratricopeptide repeat TPR_14 PF13428.1 KOO34531.1 - 1.8e-15 56.0 18.0 0.17 12.6 0.1 7.6 5 2 2 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO34531.1 - 1.9e-15 55.7 4.9 0.27 11.5 0.0 7.7 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO34531.1 - 1.5e-14 52.6 4.1 0.14 12.1 0.0 7.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_4 PF07721.9 KOO34531.1 - 4.2e-12 45.2 6.2 0.16 12.4 0.0 7.8 7 0 0 7 7 7 1 Tetratricopeptide repeat Apc3 PF12895.2 KOO34531.1 - 1.2e-10 41.3 0.9 0.003 17.6 0.1 4.6 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 KOO34531.1 - 1.9e-10 40.9 10.2 0.017 15.4 0.2 5.5 1 1 4 6 6 6 3 Tetratricopeptide repeat PPR PF01535.15 KOO34531.1 - 1.5e-09 37.1 2.6 4.5 7.4 0.0 7.3 7 0 0 7 7 7 1 PPR repeat TPR_5 PF12688.2 KOO34531.1 - 1.5e-06 28.2 17.1 0.00052 20.0 2.8 4.4 1 1 2 4 4 4 3 Tetratrico peptide repeat TPR_20 PF14561.1 KOO34531.1 - 2.3e-06 27.6 20.3 0.52 10.4 0.1 7.0 1 1 3 5 5 5 2 Tetratricopeptide repeat ApoLp-III PF07464.6 KOO34531.1 - 3.1e-05 24.0 19.1 0.022 14.8 0.5 5.2 2 1 5 7 7 6 3 Apolipophorin-III precursor (apoLp-III) DUF3856 PF12968.2 KOO34531.1 - 3.6e-05 23.6 13.9 0.16 11.7 2.2 5.7 1 1 3 5 5 5 3 Domain of Unknown Function (DUF3856) TPR_8 PF13181.1 KOO34531.1 - 6.2e-05 22.4 1.9 13 5.8 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat Gly_radical PF01228.16 KOO34531.1 - 0.00015 22.0 1.2 2.9 8.2 0.0 3.6 2 1 1 3 3 3 1 Glycine radical DUF4583 PF15190.1 KOO34531.1 - 0.00075 19.1 0.6 0.0023 17.5 0.4 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4583) TPR_6 PF13174.1 KOO34531.1 - 0.0011 19.3 12.1 2.1 9.0 0.1 7.3 8 1 0 8 8 7 1 Tetratricopeptide repeat DUF627 PF04781.7 KOO34531.1 - 0.02 14.5 0.2 5.4 6.6 0.0 4.0 3 1 2 5 5 5 0 Protein of unknown function (DUF627) Fis1_TPR_C PF14853.1 KOO34531.1 - 0.6 10.0 4.1 33 4.4 0.1 4.2 5 0 0 5 5 3 0 Fis1 C-terminal tetratricopeptide repeat Rab5-bind PF09311.6 KOO34531.1 - 1.5 8.7 19.3 1.5 8.7 2.5 5.1 2 1 1 5 5 5 0 Rabaptin-like protein Spectrin PF00435.16 KOO34531.1 - 3.8 7.8 18.8 0.26 11.6 0.5 4.2 3 1 1 4 4 4 0 Spectrin repeat LRR_6 PF13516.1 KOO34533.1 - 1.1e-22 77.5 0.7 0.00013 21.6 0.0 4.5 4 0 0 4 4 4 4 Leucine Rich repeat LRR_4 PF12799.2 KOO34533.1 - 5.2e-07 29.1 0.6 0.41 10.3 0.1 3.9 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO34533.1 - 2e-06 27.0 0.0 3.8 7.9 0.0 4.6 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_7 PF13504.1 KOO34533.1 - 2.9e-05 23.5 0.5 9.2 6.9 0.0 4.5 4 0 0 4 4 4 2 Leucine rich repeat LRR_8 PF13855.1 KOO34533.1 - 0.0013 18.4 2.2 1.2 8.9 0.8 3.5 1 1 1 2 2 2 2 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO34533.1 - 0.33 11.1 1.4 2.4 8.3 0.1 2.5 2 2 1 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding Myosin_tail_1 PF01576.14 KOO34534.1 - 0.00022 19.1 81.4 0.013 13.2 8.2 3.3 2 1 1 3 3 3 3 Myosin tail UCN2 PF11613.3 KOO34534.1 - 3.1 7.8 7.9 12 5.8 4.6 2.8 2 0 0 2 2 2 0 Agonist of corticotropin releasing factor R2, Urocortin-2 SPX PF03105.14 KOO34534.1 - 5.4 6.7 23.5 9.6 5.8 0.4 4.2 1 1 2 3 3 3 0 SPX domain RNA_pol_Rpb1_1 PF04997.7 KOO34536.1 - 4.8e-32 111.5 0.0 8.4e-32 110.7 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 BTV_NS2 PF04514.7 KOO34536.1 - 0.0035 16.2 1.9 0.0035 16.2 1.3 2.0 1 1 1 2 2 2 1 Bluetongue virus non-structural protein NS2 NPV_P10 PF05531.7 KOO34536.1 - 1.3 9.3 6.6 5.9 7.2 0.2 3.7 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Jnk-SapK_ap_N PF09744.4 KOO34536.1 - 3.8 7.4 9.4 11 5.9 2.2 2.4 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Lipase_GDSL_2 PF13472.1 KOO34537.1 - 8.4e-25 87.9 1.4 8.4e-25 87.9 1.0 1.4 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 KOO34537.1 - 1.8e-08 34.5 0.0 4.3e-08 33.2 0.0 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Aminotran_1_2 PF00155.16 KOO34538.1 - 1.4e-87 294.0 0.0 2.6e-52 177.9 0.0 2.2 2 0 0 2 2 2 2 Aminotransferase class I and II PqiA PF04403.8 KOO34538.1 - 2e-08 33.9 6.6 0.00028 20.5 0.8 2.8 2 0 0 2 2 2 2 Paraquat-inducible protein A PAP2 PF01569.16 KOO34538.1 - 2.5e-07 30.4 2.7 2.5e-07 30.4 1.9 3.2 3 0 0 3 3 3 1 PAP2 superfamily Pkinase PF00069.20 KOO34539.1 - 4.4e-46 157.1 0.0 7.9e-46 156.3 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34539.1 - 3.4e-21 75.4 0.1 4.4e-11 42.3 0.2 3.0 2 1 0 2 2 2 2 Protein tyrosine kinase YrbL-PhoP_reg PF10707.4 KOO34539.1 - 0.0036 16.6 0.0 0.11 11.7 0.0 2.2 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL Kinase-like PF14531.1 KOO34539.1 - 0.064 12.2 0.0 4.5 6.1 0.0 2.8 3 0 0 3 3 3 0 Kinase-like Orai-1 PF07856.7 KOO34540.1 - 0.14 11.7 3.4 0.15 11.6 2.4 1.2 1 0 0 1 1 1 0 Mediator of CRAC channel activity DUF2964 PF11177.3 KOO34540.1 - 3.1 7.7 7.2 4.6 7.2 4.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2964) Galactosyl_T PF01762.16 KOO34541.1 - 2.7e-10 40.1 0.0 5.3e-10 39.2 0.0 1.5 1 1 0 1 1 1 1 Galactosyltransferase Fringe PF02434.11 KOO34541.1 - 0.074 12.2 0.1 0.13 11.4 0.1 1.4 1 1 0 1 1 1 0 Fringe-like Gene66 PF02053.10 KOO34544.1 - 0.011 15.2 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 0 Gene 66 (IR5) protein Pkinase PF00069.20 KOO34545.1 - 1.6e-05 24.1 0.0 2.5e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34545.1 - 0.11 11.6 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase Kua-UEV1_localn PF10520.4 KOO34546.1 - 2e-28 99.2 0.1 2e-28 99.2 0.1 2.0 2 0 0 2 2 2 1 Kua-ubiquitin conjugating enzyme hybrid localisation domain LRR_6 PF13516.1 KOO34547.1 - 8.1e-11 40.8 11.8 0.012 15.5 0.1 7.3 7 0 0 7 7 7 4 Leucine Rich repeat LRR_1 PF00560.28 KOO34547.1 - 8.6e-07 28.1 2.3 3.4 8.0 0.1 6.1 6 0 0 6 6 6 2 Leucine Rich Repeat Skp1 PF01466.14 KOO34547.1 - 6.5e-06 26.0 0.0 1.5e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Skp1 family, dimerisation domain LRR_7 PF13504.1 KOO34547.1 - 0.0077 16.2 10.3 5 7.7 0.2 5.5 5 0 0 5 5 5 1 Leucine rich repeat LRR_8 PF13855.1 KOO34547.1 - 0.028 14.1 7.5 4.3 7.1 0.4 4.2 4 2 0 4 4 4 0 Leucine rich repeat LRR_4 PF12799.2 KOO34547.1 - 0.043 13.4 10.4 3.7 7.2 0.3 4.4 5 1 0 5 5 5 0 Leucine Rich repeats (2 copies) MAGE PF01454.14 KOO34548.1 - 1.2e-19 70.4 0.0 1.8e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 MAGE family Pkinase PF00069.20 KOO34550.1 - 6.3e-62 209.0 0.0 9.4e-62 208.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34550.1 - 6.9e-26 90.8 0.0 9.9e-26 90.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.1 KOO34550.1 - 3.8e-18 65.3 0.9 3.6e-10 39.8 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO34550.1 - 9.9e-18 62.0 1.0 2.6e-06 26.3 0.0 3.8 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.1 KOO34550.1 - 1.3e-16 58.9 1.7 1.5e-05 24.4 0.0 3.7 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.1 KOO34550.1 - 8.7e-14 50.8 2.6 4.2e-05 23.0 0.1 4.0 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO34550.1 - 1.2e-11 43.3 1.6 1.5e-05 24.1 0.1 3.1 3 0 0 3 3 3 2 EF hand Kinase-like PF14531.1 KOO34550.1 - 1e-05 24.6 0.0 2.6e-05 23.3 0.0 1.6 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.9 KOO34550.1 - 0.0011 18.0 0.1 0.0029 16.6 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO34550.1 - 0.0042 16.8 0.4 0.05 13.3 0.0 2.3 2 0 0 2 2 2 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 KOO34550.1 - 0.034 13.4 0.0 0.062 12.6 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Sp38 PF07354.7 KOO34550.1 - 0.09 11.4 0.0 0.15 10.6 0.0 1.2 1 0 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) SPARC_Ca_bdg PF10591.4 KOO34550.1 - 0.095 12.7 0.3 6.1 6.9 0.0 2.6 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Choline_kinase PF01633.15 KOO34550.1 - 0.11 12.0 0.1 0.24 10.9 0.1 1.6 1 1 0 1 1 1 0 Choline/ethanolamine kinase Ank_2 PF12796.2 KOO34551.1 - 1.6e-28 98.8 0.9 1.2e-13 51.1 0.4 3.0 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO34551.1 - 2.3e-24 85.2 5.8 7e-08 32.7 0.1 4.9 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.25 KOO34551.1 - 6.9e-24 82.4 2.5 2.1e-07 30.3 0.0 5.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 KOO34551.1 - 2.8e-19 68.6 3.7 4.5e-09 36.2 0.0 4.1 3 1 1 4 4 4 2 Ankyrin repeats (many copies) TPR_11 PF13414.1 KOO34551.1 - 4.6e-12 45.4 2.8 2.4e-08 33.4 0.0 3.6 4 0 0 4 4 4 2 TPR repeat Ank_3 PF13606.1 KOO34551.1 - 1.5e-11 43.3 1.5 0.0031 17.6 0.0 5.0 5 0 0 5 5 4 2 Ankyrin repeat TPR_1 PF00515.23 KOO34551.1 - 2.9e-06 26.6 0.2 0.17 11.5 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO34551.1 - 0.00035 20.2 4.1 2.3 8.3 0.1 4.1 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO34551.1 - 0.0016 19.0 0.1 0.0016 19.0 0.0 5.2 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOO34551.1 - 0.0043 16.8 4.7 1.6 8.6 0.0 3.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO34551.1 - 0.0057 17.1 15.2 0.97 10.2 0.0 5.5 4 1 0 4 4 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO34551.1 - 0.093 12.9 0.3 2.8 8.3 0.0 3.2 3 0 0 3 3 2 0 Tetratricopeptide repeat EF-hand_1 PF00036.27 KOO34552.1 - 1.9e-15 54.8 2.1 1.6e-06 27.0 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.1 KOO34552.1 - 2.5e-13 48.6 5.3 4.7e-07 28.8 0.1 2.7 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO34552.1 - 2.7e-13 48.5 2.7 1.6e-07 30.5 0.0 3.0 3 1 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO34552.1 - 2.9e-13 49.7 0.2 5.1e-13 48.9 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO34552.1 - 8.2e-12 44.5 0.4 8.7e-07 28.4 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair Peptidase_C14 PF00656.17 KOO34552.1 - 0.0058 16.3 0.0 0.0075 15.9 0.0 1.2 1 0 0 1 1 1 1 Caspase domain YqzH PF14164.1 KOO34552.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 YqzH-like protein Toprim PF01751.17 KOO34552.1 - 0.14 12.1 0.2 0.3 11.0 0.0 1.6 1 1 1 2 2 2 0 Toprim domain Asp_Arg_Hydrox PF05118.10 KOO34553.1 - 8.6e-14 51.7 0.0 3.3e-13 49.8 0.0 1.9 2 0 0 2 2 2 1 Aspartyl/Asparaginyl beta-hydroxylase TPR_1 PF00515.23 KOO34553.1 - 0.012 15.1 0.0 0.34 10.5 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO34553.1 - 0.013 15.4 0.4 0.65 10.0 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.1 KOO34553.1 - 0.02 15.0 0.1 4.8 7.6 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat LRR_6 PF13516.1 KOO34554.1 - 9.4e-11 40.6 1.5 0.012 15.6 0.1 5.4 5 0 0 5 5 5 4 Leucine Rich repeat LRR_1 PF00560.28 KOO34554.1 - 1.7e-05 24.2 0.0 2 8.7 0.0 4.2 4 0 0 4 4 4 2 Leucine Rich Repeat LRR_7 PF13504.1 KOO34554.1 - 0.00043 20.0 1.3 2.2 8.8 0.1 3.9 4 0 0 4 4 4 2 Leucine rich repeat LRR_4 PF12799.2 KOO34554.1 - 0.0052 16.3 2.1 0.43 10.2 0.5 3.5 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) DUF902 PF06001.8 KOO34554.1 - 0.14 12.3 0.1 22 5.3 0.0 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF902) LRR_8 PF13855.1 KOO34554.1 - 0.17 11.6 2.2 15 5.4 0.6 3.3 3 1 0 3 3 3 0 Leucine rich repeat DUF4384 PF14326.1 KOO34558.1 - 0.12 12.2 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4384) WD40 PF00400.27 KOO34559.1 - 1.1e-104 338.9 46.7 3e-12 45.9 0.3 11.2 11 0 0 11 11 11 10 WD domain, G-beta repeat PD40 PF07676.7 KOO34559.1 - 7.1e-16 57.4 7.5 1.3 8.7 0.0 8.6 8 0 0 8 8 8 8 WD40-like Beta Propeller Repeat AAA_16 PF13191.1 KOO34559.1 - 5.1e-10 39.6 0.9 7e-09 35.9 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.7 KOO34559.1 - 5.4e-08 32.6 0.0 1.2e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Nbas_N PF15492.1 KOO34559.1 - 1e-07 31.3 7.5 1.1 8.3 0.0 5.8 1 1 5 7 7 7 4 Neuroblastoma-amplified sequence, N terminal DUF3312 PF11768.3 KOO34559.1 - 0.00069 17.9 0.0 6.1 4.9 0.0 3.8 1 1 2 4 4 4 1 Protein of unknown function (DUF3312) DCX PF03607.12 KOO34559.1 - 0.00072 19.0 0.0 13 5.5 0.0 6.2 9 0 0 9 9 9 1 Doublecortin KAP_NTPase PF07693.9 KOO34559.1 - 0.003 16.6 0.0 0.57 9.1 0.0 2.5 2 0 0 2 2 2 2 KAP family P-loop domain DUF4467 PF14729.1 KOO34559.1 - 0.038 14.3 0.0 1.5e+02 2.7 0.0 4.8 2 1 3 5 5 5 0 Domain of unknown function with cystatin-like fold (DUF4467) Dfp1_Him1_M PF08630.5 KOO34559.1 - 0.28 10.9 8.6 47 3.7 0.0 6.1 7 0 0 7 7 7 0 Dfp1/Him1, central region EF-hand_6 PF13405.1 KOO34561.1 - 5.6e-06 25.8 2.2 0.003 17.2 0.0 3.0 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.1 KOO34561.1 - 0.00012 22.0 0.2 0.0017 18.4 0.2 2.3 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO34561.1 - 0.0021 17.2 0.1 0.0056 15.8 0.0 1.8 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.1 KOO34561.1 - 0.0078 15.5 0.1 0.021 14.1 0.1 1.8 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 KOO34561.1 - 0.022 14.3 0.1 0.06 12.9 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_like PF09279.6 KOO34561.1 - 0.14 12.2 0.5 0.43 10.6 0.1 1.9 1 1 1 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like UBA PF00627.26 KOO34563.1 - 3.2e-05 23.6 0.1 5.2e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 UBA/TS-N domain UBA_4 PF14555.1 KOO34563.1 - 4.3e-05 22.9 0.0 6.7e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain ERG4_ERG24 PF01222.12 KOO34564.1 - 1.5e-43 148.9 0.0 3.9e-43 147.5 0.0 1.5 1 1 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 KOO34564.1 - 0.018 14.3 0.1 0.03 13.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) fn3 PF00041.16 KOO34565.1 - 1.4e-08 34.6 0.0 2.2e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Fibronectin type III domain ADPrib_exo_Tox PF03496.9 KOO34567.1 - 1.6e-05 24.2 0.0 0.0092 15.2 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosyltransferase exoenzyme ART PF01129.13 KOO34567.1 - 0.0006 18.9 0.0 0.0015 17.6 0.0 1.7 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase FTO_CTD PF12934.2 KOO34567.1 - 0.086 12.4 1.2 0.29 10.6 0.0 2.3 3 0 0 3 3 3 0 FTO C-terminal domain U-box PF04564.10 KOO34568.1 - 7.7e-12 44.9 0.1 2.1e-11 43.6 0.0 1.7 2 0 0 2 2 2 1 U-box domain Sel1 PF08238.7 KOO34568.1 - 7.6e-11 42.2 12.6 0.00024 21.6 0.8 4.1 4 0 0 4 4 4 3 Sel1 repeat zf-Nse PF11789.3 KOO34568.1 - 0.0005 19.5 0.0 0.00094 18.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit LRR_5 PF13306.1 KOO34569.1 - 3.8e-31 107.4 0.5 4.1e-31 107.3 0.4 1.0 1 0 0 1 1 1 1 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO34569.1 - 2.1e-06 27.3 0.0 0.00057 19.5 0.0 2.1 1 1 1 2 2 2 2 Leucine rich repeat DUF4072 PF13284.1 KOO34569.1 - 0.12 12.5 0.0 2.2 8.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4072) Sel1 PF08238.7 KOO34570.1 - 3.9e-14 52.7 17.4 3.3e-08 33.8 1.6 4.4 4 0 0 4 4 4 3 Sel1 repeat U-box PF04564.10 KOO34570.1 - 4.5e-12 45.7 0.1 1.3e-11 44.2 0.0 1.8 2 0 0 2 2 2 1 U-box domain zf-Nse PF11789.3 KOO34570.1 - 0.00024 20.5 0.0 0.00088 18.7 0.0 1.9 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit TPR_6 PF13174.1 KOO34570.1 - 0.036 14.5 3.0 0.09 13.2 0.2 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Ank_2 PF12796.2 KOO34572.1 - 8.3e-10 38.8 0.1 4.1e-09 36.6 0.1 2.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) PfkB PF00294.19 KOO34572.1 - 1.8e-09 37.1 2.0 8e-05 21.9 0.0 3.3 3 0 0 3 3 3 2 pfkB family carbohydrate kinase Ank PF00023.25 KOO34572.1 - 2.3e-07 30.2 6.5 1.8e-05 24.2 0.1 3.8 3 0 0 3 3 3 2 Ankyrin repeat TIR_2 PF13676.1 KOO34572.1 - 4.6e-07 29.9 0.6 0.002 18.2 0.1 3.1 2 0 0 2 2 2 2 TIR domain Ank_3 PF13606.1 KOO34572.1 - 4e-06 26.5 4.9 0.00091 19.2 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.1 KOO34572.1 - 5.2e-06 26.8 1.8 2.3e-05 24.7 0.2 2.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO34572.1 - 4.5e-05 23.5 1.9 0.0014 18.7 0.1 3.5 3 1 1 4 4 4 1 Ankyrin repeats (many copies) TIR PF01582.15 KOO34572.1 - 0.27 10.6 0.0 0.99 8.8 0.0 1.9 2 0 0 2 2 2 0 TIR domain TIR_2 PF13676.1 KOO34573.1 - 8.1e-10 38.7 0.0 2.2e-09 37.3 0.0 1.8 1 0 0 1 1 1 1 TIR domain Methyltransf_26 PF13659.1 KOO34573.1 - 9.7e-09 35.2 3.5 7.3e-08 32.4 0.1 3.2 3 0 0 3 3 3 1 Methyltransferase domain RrnaAD PF00398.15 KOO34573.1 - 2.2e-08 33.4 0.0 3.6e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase EF-hand_5 PF13202.1 KOO34573.1 - 9.2e-06 24.7 0.1 2.5e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KOO34573.1 - 0.00014 20.8 0.0 0.00035 19.6 0.0 1.6 1 0 0 1 1 1 1 EF hand MTS PF05175.9 KOO34573.1 - 0.00039 19.8 0.0 0.0011 18.3 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase small domain Methyltransf_11 PF08241.7 KOO34573.1 - 0.0004 20.8 0.7 0.0031 17.9 0.0 2.8 3 0 0 3 3 3 1 Methyltransferase domain AAA_17 PF13207.1 KOO34573.1 - 0.00057 20.7 0.0 0.0015 19.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 KOO34573.1 - 0.0011 18.6 0.0 0.0061 16.2 0.0 2.0 1 1 0 1 1 1 1 NACHT domain EF-hand_7 PF13499.1 KOO34573.1 - 0.0023 18.0 0.0 0.013 15.6 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain pair AAA_22 PF13401.1 KOO34573.1 - 0.0038 17.3 0.0 0.0098 16.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain EF-hand_6 PF13405.1 KOO34573.1 - 0.0046 16.7 0.1 0.018 14.8 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain AAA_18 PF13238.1 KOO34573.1 - 0.006 16.8 0.1 0.012 15.8 0.1 1.5 1 0 0 1 1 1 1 AAA domain TIR PF01582.15 KOO34573.1 - 0.0064 15.9 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 TIR domain Methyltransf_12 PF08242.7 KOO34573.1 - 0.008 16.6 0.0 0.025 15.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain AAA_25 PF13481.1 KOO34573.1 - 0.0087 15.4 0.0 0.02 14.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain Methyltransf_23 PF13489.1 KOO34573.1 - 0.021 14.5 0.0 0.045 13.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain AAA_28 PF13521.1 KOO34573.1 - 0.026 14.5 0.0 0.054 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 KOO34573.1 - 0.036 13.6 0.0 0.085 12.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Viral_helicase1 PF01443.13 KOO34573.1 - 0.037 13.5 0.0 0.066 12.7 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase EF-hand_8 PF13833.1 KOO34573.1 - 0.043 13.4 0.1 0.14 11.7 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain pair Methyltransf_18 PF12847.2 KOO34573.1 - 0.06 13.9 0.0 0.06 13.9 0.0 2.5 3 0 0 3 3 1 0 Methyltransferase domain AAA_33 PF13671.1 KOO34573.1 - 0.082 12.7 0.1 0.28 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain UBA PF00627.26 KOO34574.1 - 2.7e-05 23.8 1.4 2.9e-05 23.7 0.2 1.7 2 0 0 2 2 2 1 UBA/TS-N domain CUE PF02845.11 KOO34574.1 - 0.02 14.3 0.1 0.039 13.4 0.0 1.5 1 0 0 1 1 1 0 CUE domain UBA_4 PF14555.1 KOO34574.1 - 0.11 12.0 0.1 0.22 11.0 0.1 1.4 1 0 0 1 1 1 0 UBA-like domain BSD PF03909.12 KOO34575.1 - 2.4e-06 27.1 0.0 4.4e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 BSD domain Maf PF02545.9 KOO34576.1 - 1e-21 76.9 0.0 1.2e-21 76.6 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein FUSC PF04632.7 KOO34577.1 - 0.068 11.6 8.5 0.073 11.4 5.9 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Pro_isomerase PF00160.16 KOO34578.1 - 6.4e-29 101.1 0.0 8.5e-29 100.7 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PDZ PF00595.19 KOO34579.1 - 1.6e-05 25.0 3.0 1.8e-05 24.8 0.3 2.5 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) ST7 PF04184.7 KOO34579.1 - 0.03 12.5 2.2 0.094 10.9 1.0 1.8 1 1 1 2 2 2 0 ST7 protein PDZ_2 PF13180.1 KOO34579.1 - 0.043 13.7 0.2 0.14 12.0 0.2 2.0 1 0 0 1 1 1 0 PDZ domain Tricorn_PDZ PF14685.1 KOO34579.1 - 0.64 9.8 2.6 1.1 9.0 0.2 2.6 2 1 1 3 3 3 0 Tricorn protease PDZ domain Tup_N PF08581.5 KOO34579.1 - 2.4 8.4 7.3 0.36 11.0 0.9 2.3 2 0 0 2 2 2 0 Tup N-terminal EF-hand_1 PF00036.27 KOO34580.1 - 3.7e-25 85.2 6.7 8.1e-06 24.7 0.2 5.6 5 0 0 5 5 5 5 EF hand EF-hand_7 PF13499.1 KOO34580.1 - 3.9e-23 81.3 5.0 4.6e-09 36.2 0.1 3.6 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO34580.1 - 4e-22 77.5 8.1 4.9e-08 32.4 0.0 4.5 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO34580.1 - 7.4e-20 69.0 10.3 0.00061 19.4 0.0 5.6 5 0 0 5 5 5 5 EF-hand domain EF-hand_5 PF13202.1 KOO34580.1 - 1.7e-17 61.9 10.3 7.4e-05 21.9 0.2 4.8 5 0 0 5 5 5 3 EF hand SPARC_Ca_bdg PF10591.4 KOO34580.1 - 6.9e-05 22.8 0.0 0.082 12.9 0.0 2.7 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO34580.1 - 0.0023 17.6 4.1 0.29 10.8 0.2 3.4 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO34580.1 - 0.092 12.4 0.2 0.3 10.7 0.0 1.9 2 0 0 2 2 2 0 EF hand PIG-P PF08510.7 KOO34582.1 - 4.9e-08 32.6 0.0 6.4e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 PIG-P Cation_efflux PF01545.16 KOO34582.1 - 0.0067 15.5 0.1 0.0074 15.3 0.0 1.1 1 0 0 1 1 1 1 Cation efflux family TPR_19 PF14559.1 KOO34583.1 - 0.14 12.4 10.1 1.9 8.8 0.4 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat CRAL_TRIO PF00650.15 KOO34584.1 - 0.023 14.1 0.0 0.037 13.5 0.0 1.3 1 0 0 1 1 1 0 CRAL/TRIO domain Esterase PF00756.15 KOO34585.1 - 2.5e-55 187.6 0.0 2.8e-55 187.4 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Abhydrolase_5 PF12695.2 KOO34585.1 - 1.3e-06 28.2 0.1 1.9e-06 27.7 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase_phd PF10503.4 KOO34585.1 - 0.00011 21.5 0.2 0.00074 18.8 0.0 2.0 2 1 0 2 2 2 1 Esterase PHB depolymerase Abhydrolase_6 PF12697.2 KOO34585.1 - 0.00065 19.6 0.2 0.0011 18.8 0.1 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 KOO34585.1 - 0.027 13.3 0.0 0.044 12.6 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme KH_1 PF00013.24 KOO34586.1 - 1.3e-29 101.6 0.0 3.9e-06 26.4 0.0 6.2 6 0 0 6 6 6 6 KH domain KH_3 PF13014.1 KOO34586.1 - 1.7e-17 62.6 0.1 0.18 11.5 0.0 6.6 6 0 0 6 6 6 6 KH domain KH_2 PF07650.12 KOO34586.1 - 2.6e-06 26.8 0.0 0.73 9.4 0.0 5.0 4 1 0 5 5 5 1 KH domain KH_4 PF13083.1 KOO34586.1 - 0.0018 17.8 0.1 23 4.7 0.0 4.2 4 0 0 4 4 4 1 KH domain Hormone_2 PF00123.15 KOO34586.1 - 0.4 10.5 1.6 29 4.6 0.0 3.4 3 0 0 3 3 3 0 Peptide hormone PIF1 PF05970.9 KOO34587.1 - 9.4e-30 103.7 0.0 2.6e-20 72.6 0.0 2.5 2 1 0 2 2 2 2 PIF1-like helicase AAA_30 PF13604.1 KOO34587.1 - 9e-18 64.5 0.0 1.1e-14 54.4 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 KOO34587.1 - 1.6e-09 37.3 0.5 4.5e-09 35.9 0.4 1.8 1 0 0 1 1 1 1 Part of AAA domain AAA_11 PF13086.1 KOO34587.1 - 7.2e-06 25.7 0.0 0.014 14.9 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 KOO34587.1 - 0.00022 21.3 0.1 0.0012 18.9 0.0 2.1 2 1 0 2 2 2 1 AAA domain Helicase_RecD PF05127.9 KOO34587.1 - 0.00042 20.0 0.8 0.034 13.7 0.4 2.9 2 1 0 2 2 2 1 Helicase Viral_helicase1 PF01443.13 KOO34587.1 - 0.0033 16.9 0.0 0.006 16.1 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.10 KOO34587.1 - 0.0035 17.0 0.1 0.014 15.1 0.0 2.0 3 0 0 3 3 3 1 NTPase AAA_5 PF07728.9 KOO34587.1 - 0.009 15.7 0.2 0.039 13.6 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOO34587.1 - 0.0099 15.8 0.1 0.038 13.9 0.0 1.9 1 1 1 2 2 2 1 AAA ATPase domain NACHT PF05729.7 KOO34587.1 - 0.016 14.8 0.0 0.055 13.1 0.0 1.7 2 0 0 2 2 2 0 NACHT domain AAA PF00004.24 KOO34587.1 - 0.029 14.5 0.0 0.05 13.7 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ArgK PF03308.11 KOO34587.1 - 0.04 12.6 0.1 0.066 11.9 0.0 1.3 1 0 0 1 1 1 0 ArgK protein AAA_10 PF12846.2 KOO34587.1 - 0.042 13.2 0.1 0.091 12.1 0.1 1.5 2 0 0 2 2 2 0 AAA-like domain TrwB_AAD_bind PF10412.4 KOO34587.1 - 0.079 11.5 0.0 0.13 10.8 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain DUF2075 PF09848.4 KOO34587.1 - 0.11 11.5 0.0 0.15 10.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Nucleotid_trans PF03407.11 KOO34588.1 - 1.8e-28 99.7 0.0 5.7e-28 98.1 0.0 1.8 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase ARL2_Bind_BART PF11527.3 KOO34589.1 - 9.4e-11 41.5 0.0 1.2e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART BRO1 PF03097.13 KOO34591.1 - 4.4e-44 150.7 0.0 1.7e-43 148.8 0.0 1.9 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 KOO34591.1 - 3.2e-17 62.4 10.6 6.6e-17 61.4 7.4 1.5 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV Pkinase PF00069.20 KOO34592.1 - 9e-33 113.5 0.0 1.2e-32 113.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34592.1 - 2.8e-27 95.4 0.0 3.5e-27 95.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO34592.1 - 0.0014 18.4 0.2 0.0026 17.5 0.1 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family 2OG-FeII_Oxy_3 PF13640.1 KOO34593.1 - 5.4e-08 33.2 2.0 1.5e-07 31.8 1.3 1.9 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Pkinase_Tyr PF07714.12 KOO34593.1 - 0.001 18.2 0.0 0.0018 17.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ofd1_CTDD PF10637.4 KOO34593.1 - 0.0027 16.8 0.0 0.093 11.8 0.0 2.3 1 1 0 1 1 1 1 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.1 KOO34593.1 - 0.067 12.8 1.3 0.15 11.7 0.9 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DUF4525 PF15027.1 KOO34594.1 - 0.0093 15.4 0.0 0.024 14.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4525) DUF3887 PF13026.1 KOO34594.1 - 0.019 15.1 1.1 0.069 13.4 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3887) Peptidase_M15_2 PF05951.8 KOO34594.1 - 0.056 12.8 0.0 0.58 9.5 0.0 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF882) LVIVD PF08309.6 KOO34595.1 - 1.5e-20 71.8 18.6 3.6e-09 35.4 1.1 3.5 3 0 0 3 3 3 3 LVIVD repeat Pectate_lyase_3 PF12708.2 KOO34595.1 - 0.00055 20.1 0.7 0.0011 19.1 0.1 1.7 2 0 0 2 2 2 1 Pectate lyase superfamily protein PSCyt3 PF07627.6 KOO34595.1 - 0.13 12.1 0.0 13 5.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1588) Chitin_bind_4 PF00379.18 KOO34595.1 - 0.55 10.5 8.0 15 5.9 0.0 3.8 4 0 0 4 4 4 0 Insect cuticle protein Ank_2 PF12796.2 KOO34596.1 - 6e-10 39.3 0.0 1.4e-06 28.5 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO34596.1 - 1.8e-08 33.8 0.0 0.00016 21.2 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOO34596.1 - 1.2e-07 32.0 0.1 0.00069 20.0 0.0 2.3 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO34596.1 - 6.1e-06 26.3 0.0 0.002 18.3 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO34596.1 - 7.6e-05 22.5 0.0 0.32 11.3 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeat HTH_7 PF02796.10 KOO34596.1 - 0.054 13.3 0.0 0.16 11.8 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase VCBS PF13517.1 KOO34597.1 - 2.3e-101 332.1 141.6 5.4e-13 49.0 4.5 11.5 2 1 9 11 11 11 11 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO34597.1 - 4.7e-56 185.2 125.7 3.6e-05 23.3 3.1 13.6 13 0 0 13 13 13 13 FG-GAP repeat GCC2_GCC3 PF07699.8 KOO34597.1 - 4.6e-40 134.9 199.1 8.6e-07 28.4 1.0 22.0 7 4 13 22 22 22 19 GCC2 and GCC3 TcdB_toxin_midN PF12256.3 KOO34597.1 - 3.1e-18 65.8 46.3 0.32 10.4 0.1 11.8 3 1 9 12 12 12 11 Insecticide toxin TcdB middle/N-terminal region NCD3G PF07562.9 KOO34597.1 - 0.0036 16.9 5.1 0.0036 16.9 3.5 18.0 12 7 8 21 21 20 8 Nine Cysteines Domain of family 3 GPCR Glyco_transf_56 PF07429.6 KOO34597.1 - 0.14 11.0 1.5 94 1.7 0.0 5.1 7 0 0 7 7 7 0 4-alpha-L-fucosyltransferase glycosyl transferase group 56 Methyltransf_21 PF05050.7 KOO34598.1 - 3.3e-16 59.6 0.0 4.7e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_23 PF13489.1 KOO34598.1 - 0.1 12.3 0.0 0.28 10.8 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_18 PF12847.2 KOO34598.1 - 0.11 13.1 0.0 0.18 12.4 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain OTU PF02338.14 KOO34600.1 - 0.011 16.3 0.1 0.042 14.4 0.0 2.0 2 0 0 2 2 2 0 OTU-like cysteine protease Methyltransf_18 PF12847.2 KOO34601.1 - 4.6e-10 40.0 0.0 7.4e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO34601.1 - 2.6e-08 33.5 0.0 3.9e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO34601.1 - 3e-08 33.9 0.0 5.2e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO34601.1 - 1.8e-06 28.3 0.0 2.7e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 KOO34601.1 - 4.3e-06 26.0 0.0 1e-05 24.8 0.0 1.5 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_26 PF13659.1 KOO34601.1 - 5.3e-06 26.4 0.0 1.3e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO34601.1 - 2.8e-05 23.9 0.0 3.8e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO34601.1 - 0.00026 21.4 0.0 0.00041 20.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 KOO34601.1 - 0.0011 18.5 0.0 0.0015 18.1 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.9 KOO34601.1 - 0.0081 15.5 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.7 KOO34601.1 - 0.018 14.4 0.0 0.028 13.7 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW NADH_B2 PF14813.1 KOO34601.1 - 0.06 13.0 0.9 0.13 11.9 0.6 1.5 1 0 0 1 1 1 0 NADH dehydrogenase 1 beta subcomplex subunit 2 MitMem_reg PF13012.1 KOO34602.1 - 2.5e-18 66.2 0.0 3.7e-18 65.6 0.0 1.2 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.16 KOO34602.1 - 8.2e-18 64.2 0.0 1.4e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Myb_DNA-binding PF00249.26 KOO34604.1 - 3.1e-12 46.3 0.1 7.8e-12 45.0 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO34604.1 - 0.00057 19.9 0.2 0.0016 18.4 0.0 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain SlyX PF04102.7 KOO34604.1 - 0.063 13.6 2.5 0.19 12.1 0.8 2.3 2 0 0 2 2 2 0 SlyX HHH_4 PF14490.1 KOO34604.1 - 0.083 12.6 0.4 0.68 9.7 0.0 2.2 2 0 0 2 2 2 0 Helix-hairpin-helix containing domain DUF3552 PF12072.3 KOO34604.1 - 0.089 11.9 2.0 0.16 11.1 1.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) MscS_porin PF12795.2 KOO34604.1 - 0.25 10.6 7.7 0.059 12.6 1.9 1.9 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain DivIC PF04977.10 KOO34604.1 - 2 7.9 4.6 1.1 8.7 1.0 2.0 2 0 0 2 2 2 0 Septum formation initiator UCH PF00443.24 KOO34605.1 - 6e-54 182.9 0.0 7e-54 182.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOO34605.1 - 4.7e-35 121.4 0.0 5.8e-35 121.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DnaJ PF00226.26 KOO34607.1 - 3.6e-17 61.8 0.1 6.8e-17 60.9 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Peptidase_C58 PF03543.9 KOO34607.1 - 0.046 13.2 3.0 0.17 11.3 2.1 1.9 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen DUF737 PF05300.6 KOO34607.1 - 0.13 12.2 11.2 0.31 10.9 7.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF737) AAA_13 PF13166.1 KOO34608.1 - 0.32 9.3 33.7 0.16 10.3 2.1 2.5 1 1 1 2 2 2 0 AAA domain DUF948 PF06103.6 KOO34608.1 - 6.9 6.6 12.1 24 4.8 0.0 4.5 4 1 1 5 5 5 0 Bacterial protein of unknown function (DUF948) WD40 PF00400.27 KOO34609.1 - 2.1e-22 78.1 0.0 1.3e-11 43.8 0.0 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat BBS2_Mid PF14783.1 KOO34609.1 - 0.0089 15.7 0.0 0.035 13.8 0.0 1.9 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region GHMP_kinases_N PF00288.21 KOO34609.1 - 0.032 14.2 0.0 0.09 12.8 0.0 1.8 1 0 0 1 1 1 0 GHMP kinases N terminal domain HPS3_N PF14761.1 KOO34609.1 - 0.052 12.9 0.0 0.077 12.3 0.0 1.2 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 Ndufs5 PF10200.4 KOO34610.1 - 0.00031 20.6 0.4 0.00035 20.5 0.3 1.2 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa CHCH PF06747.8 KOO34610.1 - 0.0012 18.6 0.8 0.0018 18.1 0.6 1.3 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.5 KOO34610.1 - 0.032 13.9 2.8 0.22 11.3 0.3 2.0 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Pet191_N PF10203.4 KOO34610.1 - 0.052 13.6 1.9 0.11 12.6 1.3 1.5 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Uds1 PF15456.1 KOO34611.1 - 0.0041 17.1 3.2 0.0064 16.4 2.2 1.4 1 0 0 1 1 1 1 Up-regulated During Septation Tmemb_cc2 PF10267.4 KOO34611.1 - 0.0095 14.5 1.8 0.081 11.4 0.4 2.0 2 0 0 2 2 2 1 Predicted transmembrane and coiled-coil 2 protein DUF892 PF05974.7 KOO34611.1 - 0.029 14.1 6.1 0.66 9.7 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF892) Bcr-Abl_Oligo PF09036.5 KOO34611.1 - 0.056 13.3 1.5 1.1 9.2 0.0 2.1 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain Phage_lysis PF03245.8 KOO34611.1 - 0.51 10.3 9.9 0.72 9.8 0.2 2.5 2 1 0 2 2 2 0 Bacteriophage Rz lysis protein DUF4618 PF15397.1 KOO34611.1 - 0.71 9.1 6.8 0.19 11.0 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) NTR2 PF15458.1 KOO34611.1 - 0.72 9.0 6.7 1.3 8.2 0.2 2.1 2 0 0 2 2 2 0 Nineteen complex-related protein 2 NAP PF00956.13 KOO34611.1 - 0.77 8.8 3.2 4.2 6.4 0.8 2.0 2 0 0 2 2 2 0 Nucleosome assembly protein (NAP) ADIP PF11559.3 KOO34611.1 - 1.3 8.9 8.7 2.3 8.1 0.6 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding HrpB7 PF09486.5 KOO34611.1 - 1.3 8.9 12.8 0.24 11.3 1.7 2.2 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) DUF3509 PF12021.3 KOO34611.1 - 2 8.1 7.3 6.8 6.5 0.4 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3509) DUF2730 PF10805.3 KOO34611.1 - 2.2 8.0 6.1 6.6 6.5 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) DASH_Spc19 PF08287.6 KOO34611.1 - 3 7.4 10.8 2.7 7.6 2.8 2.1 2 0 0 2 2 2 0 Spc19 IncA PF04156.9 KOO34611.1 - 6.2 6.3 17.4 2.3 7.7 2.5 2.1 1 1 1 2 2 2 0 IncA protein DUF607 PF04678.8 KOO34611.1 - 9.1 6.1 6.2 17 5.2 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function, DUF607 MORN PF02493.15 KOO34612.1 - 6.7e-20 69.5 15.1 1.3e-07 30.8 0.2 4.2 4 0 0 4 4 4 3 MORN repeat EF-hand_7 PF13499.1 KOO34612.1 - 3.5e-12 46.2 0.3 1.5e-11 44.2 0.0 2.2 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO34612.1 - 6.2e-10 38.5 1.0 2.7e-09 36.5 0.0 2.5 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO34612.1 - 9.4e-10 37.0 11.1 2.8e-05 23.1 0.3 3.9 5 0 0 5 5 5 2 EF hand EF-hand_6 PF13405.1 KOO34612.1 - 2.6e-09 36.1 4.1 0.00017 21.2 0.0 3.9 4 0 0 4 4 4 2 EF-hand domain EF-hand_9 PF14658.1 KOO34612.1 - 1.1e-06 28.4 0.0 3.1e-06 26.9 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.1 KOO34612.1 - 8.6e-06 24.8 0.9 0.062 12.6 0.0 3.1 3 0 0 3 3 3 2 EF hand PDZ PF00595.19 KOO34612.1 - 0.00027 21.0 0.0 0.00051 20.1 0.0 1.4 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) EF-hand_4 PF12763.2 KOO34612.1 - 0.00031 20.4 0.0 0.00079 19.1 0.0 1.6 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SnoaL_2 PF12680.2 KOO34612.1 - 0.017 15.4 1.2 0.34 11.3 0.0 3.1 3 1 1 4 4 4 0 SnoaL-like domain PDZ_2 PF13180.1 KOO34612.1 - 0.019 14.8 0.0 0.041 13.7 0.0 1.5 1 0 0 1 1 1 0 PDZ domain Epimerase PF01370.16 KOO34613.1 - 1e-42 146.2 0.0 2.2e-42 145.1 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 KOO34613.1 - 3.3e-10 39.3 0.0 3.2e-09 36.0 0.0 2.5 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.14 KOO34613.1 - 3.1e-08 32.6 0.0 6.1e-08 31.7 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 KOO34613.1 - 2.6e-07 29.8 0.0 0.00018 20.5 0.0 2.5 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein KIAA1430 PF13879.1 KOO34613.1 - 0.014 15.7 0.1 0.014 15.7 0.1 3.2 2 1 0 3 3 3 0 KIAA1430 homologue Herpes_UL73 PF03554.8 KOO34614.1 - 0.15 11.8 0.1 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 UL73 viral envelope glycoprotein Abhydrolase_6 PF12697.2 KOO34615.1 - 5.4e-06 26.4 2.9 2.5e-05 24.2 0.4 2.3 1 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO34615.1 - 2.6e-05 23.9 0.0 4.1e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 KOO34615.1 - 0.0041 16.7 0.1 0.0089 15.6 0.1 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.15 KOO34615.1 - 0.096 12.0 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Putative esterase OmpA PF00691.15 KOO34616.1 - 5.1e-24 84.5 0.0 7.7e-14 51.8 0.0 2.8 2 0 0 2 2 2 2 OmpA family SNARE_assoc PF09335.6 KOO34618.1 - 2.1e-17 63.4 7.3 2.1e-17 63.4 5.1 1.4 2 0 0 2 2 2 1 SNARE associated Golgi protein DBR1 PF05011.8 KOO34618.1 - 0.18 11.7 0.0 0.25 11.2 0.0 1.1 1 0 0 1 1 1 0 Lariat debranching enzyme, C-terminal domain ATP_synt_I PF03899.10 KOO34618.1 - 2.7 8.1 10.3 1.9 8.6 2.4 2.3 1 1 1 2 2 2 0 ATP synthase I chain CRCB PF02537.10 KOO34621.1 - 0.0055 16.5 0.8 7 6.5 0.1 3.5 2 1 1 3 3 3 3 CrcB-like protein Ank_2 PF12796.2 KOO34622.1 - 4.6e-86 283.2 30.3 2.8e-14 53.2 1.9 7.1 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO34622.1 - 1e-63 210.6 24.5 5.1e-09 36.4 0.1 10.1 5 4 6 11 11 11 11 Ankyrin repeats (many copies) Ank PF00023.25 KOO34622.1 - 8.7e-62 202.0 60.1 0.00011 21.8 0.2 14.1 14 0 0 14 14 14 14 Ankyrin repeat Ank_5 PF13857.1 KOO34622.1 - 2e-55 183.5 43.3 5e-08 32.9 0.8 13.2 1 1 13 14 14 14 14 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO34622.1 - 1.1e-30 102.5 22.4 0.0035 17.4 0.0 14.1 14 0 0 14 14 14 9 Ankyrin repeat DUF4182 PF13790.1 KOO34622.1 - 1.3e-11 44.1 13.0 1.6 8.5 0.0 11.2 13 0 0 13 13 13 3 Domain of unknown function (DUF4182) LIN37 PF15306.1 KOO34622.1 - 1.2e-05 25.2 0.1 7.4 6.5 0.0 6.0 7 0 0 7 7 7 1 LIN37 LTD PF00932.14 KOO34622.1 - 0.0064 16.5 0.8 6.3 6.9 0.0 4.6 4 2 1 5 5 5 1 Lamin Tail Domain PE PF00934.15 KOO34622.1 - 0.26 11.3 5.8 0.14 12.2 1.1 2.9 2 0 0 2 2 2 0 PE family Phospholip_A2_2 PF05826.7 KOO34622.1 - 1.4 8.8 12.6 0.99 9.3 0.1 4.8 2 2 4 6 6 6 0 Phospholipase A2 CoA_binding PF02629.14 KOO34623.1 - 0.15 12.6 0.0 1.5 9.4 0.0 2.4 3 0 0 3 3 3 0 CoA binding domain DUF3613 PF12266.3 KOO34623.1 - 0.37 10.3 2.6 0.27 10.7 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3613) MFS_1 PF07690.11 KOO34624.1 - 7.3e-27 93.9 41.9 8.9e-27 93.7 29.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 KOO34624.1 - 4.4e-23 81.5 26.5 1.3e-22 80.0 18.3 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter PC-Esterase PF13839.1 KOO34626.1 - 0.15 11.8 0.0 0.4 10.4 0.0 1.7 2 0 0 2 2 2 0 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p LRR_6 PF13516.1 KOO34627.1 - 3.2e-12 45.1 7.0 0.26 11.4 0.0 6.4 6 0 0 6 6 6 4 Leucine Rich repeat LRR_4 PF12799.2 KOO34627.1 - 6.4e-06 25.6 6.3 0.0045 16.5 0.1 3.7 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO34627.1 - 1.1e-05 24.7 0.1 1.5 9.1 0.0 5.4 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_7 PF13504.1 KOO34627.1 - 6.4e-05 22.5 5.0 12 6.6 0.4 5.9 5 0 0 5 5 5 1 Leucine rich repeat Skp1 PF01466.14 KOO34627.1 - 7.1e-05 22.7 0.0 0.00027 20.9 0.0 1.9 2 0 0 2 2 2 1 Skp1 family, dimerisation domain LRR_8 PF13855.1 KOO34627.1 - 0.014 15.1 7.5 1.9 8.3 0.4 4.1 3 2 0 3 3 3 0 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO34627.1 - 0.09 12.9 0.1 16 5.7 0.0 2.9 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding Glyco_transf_15 PF01793.11 KOO34628.1 - 4.3e-39 134.3 0.0 5e-39 134.1 0.0 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Pax2_C PF12403.3 KOO34628.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 Paired-box protein 2 C terminal PHD PF00628.24 KOO34629.1 - 2.7e-28 97.3 53.6 1.8e-10 40.3 4.2 4.8 3 1 1 4 4 4 4 PHD-finger Bromodomain PF00439.20 KOO34629.1 - 3.9e-10 39.5 0.0 7.8e-10 38.5 0.0 1.5 1 0 0 1 1 1 1 Bromodomain MBD PF01429.14 KOO34629.1 - 0.00077 18.9 0.0 0.0019 17.6 0.0 1.7 1 0 0 1 1 1 1 Methyl-CpG binding domain C1_1 PF00130.17 KOO34629.1 - 0.0034 17.0 48.6 0.15 11.7 0.3 6.6 5 1 0 5 5 5 2 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_2 PF13831.1 KOO34629.1 - 0.011 15.0 1.8 0.011 15.0 1.2 5.6 4 1 1 5 5 5 0 PHD-finger PQQ_2 PF13360.1 KOO34629.1 - 0.058 12.8 0.0 0.097 12.1 0.0 1.3 1 0 0 1 1 1 0 PQQ-like domain LBR_tudor PF09465.5 KOO34629.1 - 0.06 12.9 0.1 0.16 11.6 0.0 1.7 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain PQQ PF01011.16 KOO34629.1 - 0.076 12.5 0.0 0.23 11.0 0.0 1.8 1 0 0 1 1 1 0 PQQ enzyme repeat CorC_HlyC PF03471.12 KOO34630.1 - 0.068 12.9 0.0 0.068 12.9 0.0 1.1 1 0 0 1 1 1 0 Transporter associated domain PAN_4 PF14295.1 KOO34631.1 - 0.00024 20.7 1.6 0.0009 18.9 1.1 2.1 1 0 0 1 1 1 1 PAN domain PAN_1 PF00024.21 KOO34631.1 - 0.015 15.0 0.5 0.039 13.6 0.4 1.7 1 0 0 1 1 1 0 PAN domain RVT_1 PF00078.22 KOO34633.1 - 8.5e-09 35.0 0.0 9.6e-09 34.9 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PAS PF00989.19 KOO34634.1 - 0.041 13.6 0.0 0.075 12.8 0.0 1.3 1 0 0 1 1 1 0 PAS fold Kelch_1 PF01344.20 KOO34636.1 - 0.12 11.9 0.2 0.23 11.0 0.0 1.6 2 0 0 2 2 2 0 Kelch motif Abhydrolase_5 PF12695.2 KOO34637.1 - 1.6e-05 24.7 0.4 2.7e-05 23.9 0.3 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family zf-TRAF PF02176.13 KOO34638.1 - 2.1e-12 47.2 18.0 1.9e-11 44.1 6.7 3.3 3 0 0 3 3 3 2 TRAF-type zinc finger Sina PF03145.11 KOO34638.1 - 0.0005 19.7 12.8 0.0013 18.4 3.3 2.8 1 1 2 3 3 3 2 Seven in absentia protein family Vps54 PF07928.7 KOO34638.1 - 0.0019 18.3 3.5 0.17 12.0 0.1 2.3 1 1 1 2 2 2 2 Vps54-like protein Hrs_helical PF12210.3 KOO34638.1 - 0.03 14.5 0.7 0.071 13.3 0.5 1.6 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Reo_sigmaC PF04582.7 KOO34638.1 - 0.12 11.5 1.4 0.22 10.6 0.9 1.4 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Apolipoprotein PF01442.13 KOO34638.1 - 0.18 11.2 7.1 0.024 14.1 1.1 2.1 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain AAA_13 PF13166.1 KOO34638.1 - 6.8 5.0 5.8 13 4.0 0.8 2.1 2 0 0 2 2 2 0 AAA domain EF-hand_1 PF00036.27 KOO34639.1 - 8.3e-10 37.2 0.3 5.7e-05 22.1 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO34639.1 - 1.1e-09 37.3 0.7 0.00026 20.6 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO34639.1 - 8.8e-09 35.3 0.6 2.6e-08 33.8 0.4 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO34639.1 - 2.1e-07 29.9 2.7 0.0012 18.1 0.4 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO34639.1 - 0.0044 16.5 1.1 0.2 11.2 0.1 2.6 1 1 1 2 2 2 1 EF-hand domain pair zf-C4H2 PF10146.4 KOO34639.1 - 0.015 15.3 0.5 0.015 15.3 0.4 3.6 2 1 1 3 3 3 0 Zinc finger-containing protein HSBP1 PF06825.7 KOO34639.1 - 0.088 12.3 1.0 25 4.5 0.0 3.5 3 0 0 3 3 3 0 Heat shock factor binding protein 1 WD40 PF00400.27 KOO34641.1 - 1.9e-39 132.1 4.0 6.3e-09 35.3 0.0 5.3 5 0 0 5 5 5 5 WD domain, G-beta repeat Nucleoporin_N PF08801.6 KOO34641.1 - 0.0037 16.0 0.0 0.62 8.7 0.0 2.5 1 1 1 2 2 2 2 Nup133 N terminal like PQQ_3 PF13570.1 KOO34641.1 - 0.028 14.6 2.6 2.7 8.3 0.0 3.8 5 0 0 5 5 5 0 PQQ-like domain Cytochrom_D1 PF02239.11 KOO34641.1 - 0.11 10.7 0.0 1.8 6.7 0.0 2.0 2 0 0 2 2 2 0 Cytochrome D1 heme domain SAPS PF04499.10 KOO34642.1 - 2.2e-05 23.2 0.0 6.7e-05 21.7 0.0 1.7 2 0 0 2 2 2 1 SIT4 phosphatase-associated protein Dynamin_M PF01031.15 KOO34643.1 - 6.9e-41 139.9 0.0 1.1e-40 139.2 0.0 1.3 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.18 KOO34643.1 - 6.3e-38 130.2 0.0 9.7e-38 129.6 0.0 1.3 1 0 0 1 1 1 1 Dynamin family GED PF02212.13 KOO34643.1 - 2.1e-12 46.7 0.1 1.7e-11 43.8 0.0 2.4 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 KOO34643.1 - 1.8e-05 24.6 0.0 0.0002 21.3 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.1 KOO34643.1 - 0.018 15.0 0.5 0.23 11.4 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain AIG1 PF04548.11 KOO34643.1 - 0.018 14.1 0.0 0.97 8.5 0.0 2.3 2 0 0 2 2 2 0 AIG1 family FtsK_SpoIIIE PF01580.13 KOO34643.1 - 0.06 12.8 0.0 0.24 10.8 0.0 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family Miro PF08477.8 KOO34643.1 - 0.082 13.4 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 Miro-like protein IIGP PF05049.8 KOO34643.1 - 0.085 11.6 0.1 0.77 8.4 0.0 2.4 3 0 0 3 3 3 0 Interferon-inducible GTPase (IIGP) Reo_sigmaC PF04582.7 KOO34645.1 - 0.0022 17.2 2.1 0.0025 17.0 1.4 1.1 1 0 0 1 1 1 1 Reovirus sigma C capsid protein Laminin_II PF06009.7 KOO34645.1 - 0.0031 17.2 0.1 0.0041 16.8 0.1 1.2 1 0 0 1 1 1 1 Laminin Domain II DUF1664 PF07889.7 KOO34645.1 - 0.012 15.4 0.1 0.018 14.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.7 KOO34645.1 - 0.012 15.3 0.4 0.016 15.0 0.3 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus PspA_IM30 PF04012.7 KOO34645.1 - 0.013 14.8 0.8 0.017 14.4 0.5 1.1 1 0 0 1 1 1 0 PspA/IM30 family DUF4164 PF13747.1 KOO34645.1 - 0.018 15.1 0.2 0.035 14.2 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) CALCOCO1 PF07888.6 KOO34645.1 - 0.02 13.2 0.0 0.023 13.0 0.0 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like COG2 PF06148.6 KOO34645.1 - 0.027 14.3 0.2 0.038 13.8 0.1 1.3 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 SlyX PF04102.7 KOO34645.1 - 0.032 14.5 0.1 0.057 13.7 0.1 1.4 1 0 0 1 1 1 0 SlyX DUF972 PF06156.8 KOO34645.1 - 0.038 14.3 0.1 0.048 14.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF972) RmuC PF02646.11 KOO34645.1 - 0.058 12.2 0.1 0.079 11.7 0.1 1.1 1 0 0 1 1 1 0 RmuC family Mating_N PF12731.2 KOO34645.1 - 0.12 12.2 1.0 0.27 11.1 0.7 1.6 1 1 0 1 1 1 0 Mating-type protein beta 1 SSrecog PF03531.9 KOO34646.1 - 2.7e-60 203.4 0.0 4.9e-60 202.6 0.0 1.4 1 0 0 1 1 1 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.7 KOO34646.1 - 1.3e-21 76.3 1.8 7.7e-21 73.8 0.6 2.2 2 0 0 2 2 2 1 Histone chaperone Rttp106-like HMG_box PF00505.14 KOO34646.1 - 1.7e-15 57.0 0.4 1.7e-15 57.0 0.3 2.2 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO34646.1 - 1.2e-11 44.8 2.9 3.3e-11 43.3 2.0 1.9 1 0 0 1 1 1 1 HMG-box domain HMG_box_5 PF14887.1 KOO34646.1 - 0.00026 20.7 3.0 0.00026 20.7 2.1 3.1 3 0 0 3 3 3 1 HMG (high mobility group) box 5 Daxx PF03344.10 KOO34646.1 - 0.054 11.9 27.7 0.073 11.5 19.2 1.2 1 0 0 1 1 1 0 Daxx Family ACT PF01842.20 KOO34646.1 - 0.13 11.7 0.0 0.9 9.0 0.0 2.3 2 0 0 2 2 2 0 ACT domain TFIIF_alpha PF05793.7 KOO34646.1 - 2.4 6.4 53.1 0.026 12.9 29.3 2.4 3 0 0 3 3 3 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Trypsin_2 PF13365.1 KOO34647.1 - 1.8e-20 73.1 0.7 3.1e-20 72.3 0.5 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.21 KOO34647.1 - 7.6e-16 58.3 0.0 1.1e-15 57.7 0.0 1.2 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.1 KOO34647.1 - 5.8e-11 42.1 0.0 1.5e-10 40.8 0.0 1.7 1 1 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.9 KOO34647.1 - 0.0083 16.1 0.0 0.019 14.9 0.0 1.6 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain Peptidase_S46 PF10459.4 KOO34647.1 - 0.015 13.7 0.4 0.03 12.7 0.1 1.5 2 0 0 2 2 2 0 Peptidase S46 PDZ PF00595.19 KOO34647.1 - 0.068 13.3 0.1 1.6 8.9 0.0 2.8 2 1 0 2 2 2 0 PDZ domain (Also known as DHR or GLGF) Peptidase_S29 PF02907.10 KOO34647.1 - 0.21 11.0 1.2 0.33 10.4 0.1 1.9 2 0 0 2 2 2 0 Hepatitis C virus NS3 protease p450 PF00067.17 KOO34648.1 - 1.1e-13 50.5 0.0 2.1e-13 49.6 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 HrpJ PF07201.6 KOO34648.1 - 0.046 13.7 3.1 0.062 13.3 2.1 1.2 1 1 0 1 1 1 0 HrpJ-like domain LcrG PF07216.7 KOO34648.1 - 0.071 13.1 0.1 0.09 12.8 0.1 1.2 1 0 0 1 1 1 0 LcrG protein DUF3494 PF11999.3 KOO34649.1 - 0.016 14.8 4.3 0.039 13.5 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3494) Pectate_lyase_3 PF12708.2 KOO34649.1 - 0.017 15.2 1.4 0.021 14.9 0.1 1.7 2 1 0 2 2 2 0 Pectate lyase superfamily protein Bundlin PF05307.6 KOO34649.1 - 0.58 10.0 4.2 0.85 9.5 0.2 2.2 2 0 0 2 2 2 0 Bundlin RVT_2 PF07727.9 KOO34651.1 - 2.5e-17 62.6 0.0 3.3e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.21 KOO34651.1 - 2.2e-13 50.3 0.0 4.5e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain HTH_31 PF13560.1 KOO34652.1 - 0.13 12.4 4.2 0.18 12.0 0.0 2.9 3 0 0 3 3 3 0 Helix-turn-helix domain ketoacyl-synt PF00109.21 KOO34653.1 - 6.5e-53 179.8 1.3 1.1e-52 179.0 0.9 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 KOO34653.1 - 2.6e-35 120.8 1.0 6.6e-35 119.5 0.7 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 KOO34653.1 - 0.0052 15.7 0.2 0.012 14.6 0.1 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Ketoacyl-synt_2 PF13723.1 KOO34653.1 - 0.013 14.7 0.0 0.022 14.0 0.0 1.3 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain GST_C_3 PF14497.1 KOO34654.1 - 4.6e-05 23.8 0.0 9.8e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 KOO34654.1 - 7.8e-05 22.4 0.0 0.00029 20.6 0.0 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 KOO34654.1 - 0.0017 18.2 0.0 0.0032 17.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain cNMP_binding PF00027.24 KOO34655.1 - 4.8e-07 29.5 0.0 0.00028 20.6 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain PTS_IIB PF02302.12 KOO34657.1 - 7 7.2 10.1 0.31 11.5 0.8 2.9 1 1 1 3 3 3 0 PTS system, Lactose/Cellobiose specific IIB subunit YpjP PF14005.1 KOO34657.1 - 8.7 6.1 7.7 2.2 8.0 0.4 2.7 2 1 0 3 3 3 0 YpjP-like protein Hist_deacetyl PF00850.14 KOO34658.1 - 1.9e-49 168.6 0.1 5e-49 167.2 0.1 1.5 1 1 0 1 1 1 1 Histone deacetylase domain EF-hand_6 PF13405.1 KOO34659.1 - 3.8e-06 26.3 0.5 0.12 12.3 0.1 3.1 2 0 0 2 2 2 2 EF-hand domain Ank PF00023.25 KOO34659.1 - 4.8e-06 26.1 0.1 1.5e-05 24.5 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.2 KOO34659.1 - 9.5e-06 25.8 0.1 2.7e-05 24.4 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO34659.1 - 3.5e-05 24.2 0.1 9.8e-05 22.7 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) EF-hand_7 PF13499.1 KOO34659.1 - 0.0004 20.4 0.3 0.053 13.6 0.2 3.1 2 1 0 2 2 2 1 EF-hand domain pair Ank_5 PF13857.1 KOO34659.1 - 0.00041 20.4 0.0 0.0015 18.6 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) EF-hand_1 PF00036.27 KOO34659.1 - 0.0023 17.0 0.0 0.27 10.6 0.0 2.7 2 0 0 2 2 2 1 EF hand Ank_3 PF13606.1 KOO34659.1 - 0.0096 16.0 0.1 0.044 14.0 0.0 2.2 1 0 0 1 1 1 1 Ankyrin repeat DRY_EERY PF09750.4 KOO34659.1 - 0.027 14.5 3.0 0.04 14.0 0.2 2.4 2 0 0 2 2 2 0 Alternative splicing regulator Fringe PF02434.11 KOO34660.1 - 3e-06 26.6 0.0 4.1e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.16 KOO34660.1 - 1.3e-05 24.8 0.0 2.1e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase Glyco_transf_21 PF13506.1 KOO34660.1 - 0.055 12.7 0.0 0.33 10.2 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferase family 21 SSP160 PF06933.6 KOO34661.1 - 0.19 9.7 9.7 0.3 9.0 6.7 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF16 PF01519.11 KOO34661.1 - 3.7 7.8 7.4 14 5.9 4.6 2.4 1 1 0 1 1 1 0 Protein of unknown function DUF16 V_ATPase_I PF01496.14 KOO34661.1 - 5.1 4.8 8.4 8.2 4.1 5.8 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FhuF_C PF11575.3 KOO34663.1 - 3.9 7.2 6.3 2.1 8.0 0.1 3.0 3 0 0 3 3 3 0 FhuF 2Fe-2S C-terminal domain PD40 PF07676.7 KOO34664.1 - 0.44 10.2 4.8 31 4.3 0.1 3.3 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Aconitase_2_N PF06434.8 KOO34665.1 - 7.3e-87 290.0 0.0 1.2e-86 289.3 0.0 1.4 1 0 0 1 1 1 1 Aconitate hydratase 2 N-terminus Aconitase_B_N PF11791.3 KOO34665.1 - 2.7e-62 209.1 0.2 5.6e-62 208.1 0.1 1.6 1 0 0 1 1 1 1 Aconitate B N-terminal domain Aconitase PF00330.15 KOO34665.1 - 1.2e-27 96.5 0.1 5.8e-13 48.1 0.0 2.8 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) Bac_rhamnosid PF05592.6 KOO34665.1 - 0.91 7.6 2.6 0.42 8.7 0.1 1.5 2 0 0 2 2 2 0 Bacterial alpha-L-rhamnosidase HisKA_3 PF07730.8 KOO34666.1 - 0.024 14.9 5.8 0.024 14.9 4.0 3.3 1 1 1 2 2 2 0 Histidine kinase YugN PF08868.5 KOO34666.1 - 0.076 12.6 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 YugN-like family GAGA_bind PF06217.7 KOO34666.1 - 0.24 11.3 3.5 0.3 11.0 2.4 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Sbi-IV PF11621.3 KOO34666.1 - 0.36 11.0 3.3 0.25 11.5 0.2 2.3 2 0 0 2 2 2 0 C3 binding domain 4 of IgG-bind protein SBI Adeno_PIX PF03955.9 KOO34666.1 - 9 6.8 14.8 9.7 6.7 3.3 2.3 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) Occludin_ELL PF07303.8 KOO34669.1 - 0.4 11.4 4.6 0.86 10.3 3.2 1.5 1 0 0 1 1 1 0 Occludin homology domain ARGLU PF15346.1 KOO34669.1 - 6.7 6.4 13.5 0.71 9.6 3.8 2.1 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 Glyco_hydro_42 PF02449.10 KOO34670.1 - 0.0085 15.2 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 Beta-galactosidase SURNod19 PF07712.7 KOO34671.1 - 0.012 14.0 0.3 0.04 12.3 0.0 2.0 3 0 0 3 3 3 0 Stress up-regulated Nod 19 UPF0118 PF01594.11 KOO34672.1 - 1.7e-23 83.1 31.0 1.4e-22 80.1 21.5 1.9 1 1 0 1 1 1 1 Domain of unknown function DUF20 Peptidase_M50 PF02163.17 KOO34672.1 - 0.78 8.6 5.2 4.3 6.2 3.6 2.2 1 1 0 1 1 1 0 Peptidase family M50 Pcc1 PF09341.5 KOO34673.1 - 0.00013 21.8 11.6 0.04 13.9 0.0 4.7 4 2 0 4 4 4 3 Transcription factor Pcc1 Tox-PL PF15644.1 KOO34673.1 - 0.092 13.4 5.1 1.8 9.3 0.2 2.8 3 0 0 3 3 3 0 Papain fold toxin 1 DUF221 PF02714.10 KOO34676.1 - 6.7e-05 21.8 13.8 0.00069 18.5 1.5 2.9 3 1 0 3 3 3 2 Domain of unknown function DUF221 PDZ PF00595.19 KOO34676.1 - 0.004 17.2 0.0 0.0086 16.2 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) RadC PF04002.10 KOO34676.1 - 0.029 14.0 0.0 0.057 13.1 0.0 1.4 1 0 0 1 1 1 0 RadC-like JAB domain PDZ_2 PF13180.1 KOO34676.1 - 0.064 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 PDZ domain Sel1 PF08238.7 KOO34677.1 - 1.3e-74 245.0 70.1 8.5e-10 38.9 0.5 10.6 11 0 0 11 11 11 9 Sel1 repeat TFIID_30kDa PF03540.8 KOO34677.1 - 0.028 14.2 3.2 35 4.3 0.0 4.8 4 0 0 4 4 4 0 Transcription initiation factor TFIID 23-30kDa subunit DUF21 PF01595.15 KOO34677.1 - 0.11 11.8 0.2 1.7 7.9 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF21 TPR_7 PF13176.1 KOO34677.1 - 0.53 10.2 16.8 16 5.5 0.2 6.9 5 2 1 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.1 KOO34677.1 - 0.55 10.9 61.5 2 9.1 2.3 6.9 1 1 8 9 9 9 0 Tetratricopeptide repeat RVT_2 PF07727.9 KOO34680.1 - 0.0045 15.9 0.0 0.005 15.8 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) LRR_4 PF12799.2 KOO34682.1 - 5.4e-41 137.5 51.9 7.8e-07 28.5 1.3 12.6 5 3 10 16 16 16 13 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO34682.1 - 1.3e-37 127.3 37.4 9.5e-09 34.8 3.4 8.9 6 3 3 10 10 10 8 Leucine rich repeat LRR_1 PF00560.28 KOO34682.1 - 9.3e-22 73.7 45.5 0.08 13.0 0.2 18.3 21 0 0 21 21 21 7 Leucine Rich Repeat LRR_6 PF13516.1 KOO34682.1 - 6.3e-05 22.6 31.7 6.4 7.1 0.2 12.2 14 1 1 15 15 15 3 Leucine Rich repeat PSII_BNR PF14870.1 KOO34682.1 - 0.00012 21.1 0.1 0.0003 19.8 0.1 1.5 1 1 0 1 1 1 1 Photosynthesis system II assembly factor YCF48 LRR_7 PF13504.1 KOO34682.1 - 0.0079 16.2 35.0 60 4.5 0.0 14.1 17 0 0 17 17 17 0 Leucine rich repeat EGF_2 PF07974.8 KOO34682.1 - 3.6 7.8 21.4 0.52 10.5 2.0 4.5 4 0 0 4 4 4 0 EGF-like domain ATP-synt_ab PF00006.20 KOO34683.1 - 8.5e-15 54.8 0.0 9e-12 44.9 0.0 2.3 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain EF-hand_1 PF00036.27 KOO34684.1 - 0.001 18.2 0.0 0.0022 17.1 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO34684.1 - 0.0013 18.4 0.2 0.0039 16.9 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 KOO34684.1 - 0.0021 18.1 0.1 0.0071 16.4 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO34684.1 - 0.0053 16.0 0.0 0.01 15.1 0.0 1.5 1 0 0 1 1 1 1 EF hand Peptidase_S26 PF10502.4 KOO34685.1 - 1.4e-07 31.0 0.0 2.8e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.18 KOO34685.1 - 5.9e-07 29.0 0.0 1.1e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase S24-like ABC2_membrane PF01061.19 KOO34686.1 - 1.3e-37 129.0 6.0 1.9e-37 128.4 4.2 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.22 KOO34686.1 - 2.7e-24 86.0 0.0 6.6e-24 84.7 0.0 1.6 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.1 KOO34686.1 - 1.2e-08 35.2 0.0 0.00024 21.1 0.0 2.2 2 0 0 2 2 2 2 AAA domain ABC2_membrane_2 PF12679.2 KOO34686.1 - 5.7e-08 31.9 5.5 1e-07 31.1 3.8 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_3 PF12698.2 KOO34686.1 - 2.4e-07 30.1 8.0 1.3e-06 27.7 5.5 1.8 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_16 PF13191.1 KOO34686.1 - 9.7e-06 25.6 1.4 9.7e-06 25.6 1.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.14 KOO34686.1 - 8.1e-05 21.9 1.9 0.0007 18.8 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 KOO34686.1 - 0.0012 19.5 0.0 0.0027 18.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KOO34686.1 - 0.0077 16.3 0.6 0.032 14.3 0.2 2.3 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.1 KOO34686.1 - 0.024 14.0 0.8 0.058 12.7 0.5 1.6 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 KOO34686.1 - 0.024 13.8 0.7 0.044 12.9 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 KOO34686.1 - 0.033 13.7 1.0 0.086 12.3 0.7 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.1 KOO34686.1 - 0.038 13.9 0.4 0.088 12.7 0.3 1.6 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.1 KOO34686.1 - 0.055 13.3 0.1 0.38 10.6 0.0 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit MobB PF03205.9 KOO34686.1 - 0.068 12.8 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 KOO34686.1 - 0.077 13.3 0.1 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 KOO34686.1 - 0.13 11.9 0.5 0.27 10.8 0.3 1.5 1 0 0 1 1 1 0 NACHT domain Ribosomal_L39 PF00832.15 KOO34686.1 - 0.14 11.6 0.4 0.31 10.5 0.3 1.5 1 0 0 1 1 1 0 Ribosomal L39 protein FAT PF02259.18 KOO34689.1 - 0.03 13.2 0.0 0.031 13.2 0.0 1.2 1 0 0 1 1 1 0 FAT domain mRNA_cap_enzyme PF01331.14 KOO34689.1 - 0.049 13.3 0.0 0.063 12.9 0.0 1.1 1 0 0 1 1 1 0 mRNA capping enzyme, catalytic domain GTP_EFTU PF00009.22 KOO34692.1 - 8.5e-24 84.0 0.0 2e-23 82.8 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.20 KOO34692.1 - 1.8e-09 37.6 1.4 2.4e-09 37.1 0.2 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 KOO34692.1 - 2e-05 24.1 0.0 5e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 KOO34692.1 - 0.015 15.2 0.0 0.035 14.0 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase SRPRB PF09439.5 KOO34692.1 - 0.088 12.0 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Skp1 PF01466.14 KOO34693.1 - 0.0014 18.6 0.0 0.0021 18.0 0.0 1.2 1 0 0 1 1 1 1 Skp1 family, dimerisation domain DAO PF01266.19 KOO34695.1 - 7.3e-31 107.3 4.6 1.2e-17 63.8 0.4 5.3 2 2 2 4 4 4 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 KOO34695.1 - 1.3e-05 25.1 0.2 5.2e-05 23.1 0.1 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 KOO34695.1 - 0.0049 16.0 0.0 0.013 14.5 0.0 1.7 1 0 0 1 1 1 1 Thi4 family TIR_2 PF13676.1 KOO34696.1 - 7.5e-09 35.6 0.0 2.4e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 TIR domain HC2 PF07382.6 KOO34696.1 - 5.2e-07 29.7 46.5 9.3e-07 28.8 32.2 1.3 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 Cwf_Cwc_15 PF04889.7 KOO34696.1 - 0.079 12.6 14.4 0.12 12.0 10.0 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein eIF3_subunit PF08597.5 KOO34696.1 - 6.1 6.3 26.9 5e+02 0.0 18.6 2.3 1 1 0 1 1 1 0 Translation initiation factor eIF3 subunit Ank_5 PF13857.1 KOO34698.1 - 4.6e-13 48.9 1.5 1.4e-10 41.0 0.2 2.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO34698.1 - 3.7e-10 39.1 0.5 2.2e-07 30.3 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.2 KOO34698.1 - 8.6e-10 38.8 0.1 2.1e-07 31.1 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO34698.1 - 1.3e-08 35.1 0.5 2.1e-06 28.0 0.0 2.4 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO34698.1 - 3.6e-07 29.7 0.2 0.00022 21.1 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeat UQ_con PF00179.21 KOO34699.1 - 7.1e-06 25.4 0.0 1.7e-05 24.2 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme C2 PF00168.25 KOO34700.1 - 1.1e-09 38.0 0.0 2.6e-09 36.7 0.0 1.7 1 0 0 1 1 1 1 C2 domain PDZ PF00595.19 KOO34700.1 - 0.00038 20.5 0.1 0.00071 19.6 0.1 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PH PF00169.24 KOO34700.1 - 0.00099 19.2 0.0 0.0028 17.8 0.0 1.7 1 0 0 1 1 1 1 PH domain PDZ_2 PF13180.1 KOO34700.1 - 0.073 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 PDZ domain Candida_ALS_N PF11766.3 KOO34700.1 - 0.15 10.9 0.0 0.25 10.2 0.0 1.2 1 0 0 1 1 1 0 Cell-wall agglutinin N-terminal ligand-sugar binding TPR_11 PF13414.1 KOO34701.1 - 3.7e-38 128.9 18.0 4.9e-11 42.1 0.0 6.8 4 1 2 7 7 7 7 TPR repeat TPR_2 PF07719.12 KOO34701.1 - 1.1e-30 103.0 18.5 5.8e-05 22.7 0.0 10.2 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_1 PF00515.23 KOO34701.1 - 7.8e-28 94.9 16.2 5.8e-07 28.8 0.0 9.5 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_16 PF13432.1 KOO34701.1 - 3.6e-24 84.8 8.0 2.2e-05 24.9 0.0 6.4 5 1 0 6 6 6 5 Tetratricopeptide repeat TPR_12 PF13424.1 KOO34701.1 - 2.4e-21 75.4 20.6 2.4e-06 27.4 0.0 7.6 4 1 5 9 9 9 7 Tetratricopeptide repeat TPR_14 PF13428.1 KOO34701.1 - 5.5e-21 73.1 16.4 4.2e-05 23.8 0.1 8.7 4 2 6 10 10 10 6 Tetratricopeptide repeat TPR_19 PF14559.1 KOO34701.1 - 1.9e-18 66.5 9.4 4.2e-05 23.7 0.0 6.5 5 1 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO34701.1 - 8.7e-15 53.3 4.2 0.032 14.0 0.0 7.0 8 0 0 8 8 6 4 Tetratricopeptide repeat TPR_17 PF13431.1 KOO34701.1 - 5.1e-14 51.2 12.0 0.017 15.2 0.0 9.8 10 1 0 10 10 9 3 Tetratricopeptide repeat Apc3 PF12895.2 KOO34701.1 - 5.3e-11 42.5 13.2 0.017 15.2 0.7 6.1 2 1 5 7 7 7 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 KOO34701.1 - 7.4e-11 40.9 9.4 0.064 13.0 0.1 7.5 6 2 2 8 8 8 3 Tetratricopeptide repeat TPR_6 PF13174.1 KOO34701.1 - 5.8e-09 35.8 10.2 0.0088 16.4 0.1 7.9 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOO34701.1 - 8.7e-08 31.9 14.2 3.3e-05 23.6 0.5 5.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_10 PF13374.1 KOO34701.1 - 1.2e-06 28.1 9.3 2.7 8.0 0.0 6.5 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_15 PF13429.1 KOO34701.1 - 2.6e-05 23.4 4.4 0.07 12.1 0.0 3.7 2 1 0 3 3 3 2 Tetratricopeptide repeat ChAPs PF09295.5 KOO34701.1 - 0.015 14.1 0.5 0.058 12.1 0.1 2.0 1 1 1 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) Coatomer_WDAD PF04053.9 KOO34701.1 - 0.019 13.7 0.4 0.094 11.4 0.0 2.2 2 1 1 3 3 3 0 Coatomer WD associated region MIT PF04212.13 KOO34701.1 - 0.044 13.6 0.3 14 5.6 0.0 3.1 3 0 0 3 3 2 0 MIT (microtubule interacting and transport) domain PPR PF01535.15 KOO34701.1 - 0.053 13.5 2.6 18 5.6 0.0 5.0 5 0 0 5 5 4 0 PPR repeat Coatomer_E PF04733.9 KOO34701.1 - 0.57 9.3 3.2 9.8 5.2 0.0 3.0 2 1 2 4 4 4 0 Coatomer epsilon subunit PPR_3 PF13812.1 KOO34701.1 - 0.91 9.9 4.0 12 6.4 0.1 4.6 6 0 0 6 6 5 0 Pentatricopeptide repeat domain BTAD PF03704.12 KOO34701.1 - 10 6.4 11.0 34 4.7 1.3 4.3 5 0 0 5 5 5 0 Bacterial transcriptional activator domain Ank_2 PF12796.2 KOO34702.1 - 1.1e-67 224.3 39.3 3.6e-18 65.6 1.4 6.1 2 1 4 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.25 KOO34702.1 - 3.3e-65 212.8 38.2 7.6e-08 31.7 0.0 11.5 11 0 0 11 11 11 11 Ankyrin repeat Ank_4 PF13637.1 KOO34702.1 - 7.4e-46 153.7 18.2 8.2e-11 42.1 0.1 7.9 3 2 5 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO34702.1 - 3.2e-42 138.2 20.9 0.00048 20.1 0.0 11.8 12 0 0 12 12 12 9 Ankyrin repeat Ank_5 PF13857.1 KOO34702.1 - 6.8e-40 134.1 32.2 6.1e-09 35.8 0.2 8.5 4 2 4 9 9 9 8 Ankyrin repeats (many copies) NACHT PF05729.7 KOO34702.1 - 0.00037 20.1 0.0 0.0012 18.4 0.0 1.9 2 0 0 2 2 2 1 NACHT domain DDE_1 PF03184.14 KOO34702.1 - 0.035 13.2 0.1 6.8 5.7 0.0 3.4 1 1 3 4 4 4 0 DDE superfamily endonuclease Mic1 PF07035.7 KOO34702.1 - 0.11 11.8 2.1 6.3 6.1 0.1 3.2 3 0 0 3 3 3 0 Colon cancer-associated protein Mic1-like DUF1973 PF09315.6 KOO34702.1 - 0.25 10.7 3.6 15 4.9 0.0 3.8 2 1 2 4 4 4 0 Domain of unknown function (DUF1973) LRR_6 PF13516.1 KOO34704.1 - 5.1e-25 84.7 0.1 0.0027 17.6 0.0 6.3 6 0 0 6 6 6 5 Leucine Rich repeat LRR_4 PF12799.2 KOO34704.1 - 7.2e-06 25.5 0.4 0.051 13.2 0.0 4.3 2 2 1 3 3 3 1 Leucine Rich repeats (2 copies) SpoU_sub_bind PF08032.7 KOO34704.1 - 2.2e-05 24.5 4.1 0.42 10.8 0.1 4.6 3 1 1 4 4 4 2 RNA 2'-O ribose methyltransferase substrate binding LRR_8 PF13855.1 KOO34704.1 - 0.00032 20.3 0.0 1.5 8.5 0.0 3.8 2 2 2 4 4 4 2 Leucine rich repeat LRR_7 PF13504.1 KOO34704.1 - 0.0012 18.6 0.3 79 4.1 0.0 5.2 6 0 0 6 6 5 0 Leucine rich repeat LRR_1 PF00560.28 KOO34704.1 - 0.0034 17.1 0.0 1.9e+02 2.7 0.0 5.0 6 0 0 6 6 6 0 Leucine Rich Repeat Put_DNA-bind_N PF06971.8 KOO34704.1 - 0.062 13.0 2.7 45 3.9 0.0 4.6 5 0 0 5 5 5 0 Putative DNA-binding protein N-terminus HOASN PF14515.1 KOO34704.1 - 0.097 13.0 10.2 1.9 8.9 0.1 4.1 1 1 3 4 4 4 0 Haem-oxygenase-associated N-terminal helices EIF_2_alpha PF07541.7 KOO34704.1 - 0.11 12.2 0.4 3.9 7.2 0.0 2.4 1 1 2 3 3 3 0 Eukaryotic translation initiation factor 2 alpha subunit DUF2202 PF09968.4 KOO34704.1 - 0.12 12.0 2.2 7.2 6.2 0.1 3.6 1 1 4 5 5 5 0 Uncharacterized protein domain (DUF2202) CbiG_N PF11760.3 KOO34704.1 - 0.31 10.7 17.8 5.6 6.7 0.3 5.2 3 3 2 5 5 5 0 Cobalamin synthesis G N-terminal Mito_fiss_reg PF05308.6 KOO34705.1 - 0.051 12.9 7.0 0.052 12.9 4.8 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator Adeno_E1A PF02703.9 KOO34707.1 - 0.021 14.3 4.0 0.033 13.6 2.8 1.3 1 0 0 1 1 1 0 Early E1A protein KxDL PF10241.4 KOO34707.1 - 0.031 14.1 1.2 0.45 10.4 0.2 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein rve PF00665.21 KOO34707.1 - 0.1 12.7 0.4 3.6 7.7 0.3 2.4 1 1 0 1 1 1 0 Integrase core domain Laminin_II PF06009.7 KOO34707.1 - 0.14 11.9 7.6 0.045 13.4 2.2 2.2 1 1 1 2 2 2 0 Laminin Domain II CENP-K PF11802.3 KOO34707.1 - 0.82 8.8 14.3 1.6 7.9 9.9 1.6 1 1 0 1 1 1 0 Centromere-associated protein K FlaC_arch PF05377.6 KOO34707.1 - 1.2 9.0 4.6 2.5 8.0 0.1 2.7 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DPM3 PF08285.6 KOO34708.1 - 0.034 13.9 0.5 0.066 13.0 0.3 1.5 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) DUF3782 PF12644.2 KOO34708.1 - 0.33 10.7 3.5 1.6 8.5 2.5 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3782) Jnk-SapK_ap_N PF09744.4 KOO34708.1 - 3 7.7 12.3 2 8.3 3.6 2.6 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 RINT1_TIP1 PF04437.8 KOO34709.1 - 2.3e-12 46.2 0.0 1.4e-09 37.1 0.0 2.0 2 0 0 2 2 2 2 RINT-1 / TIP-1 family N6_N4_Mtase PF01555.13 KOO34711.1 - 1.5e-33 116.2 0.0 1.9e-33 115.8 0.0 1.1 1 0 0 1 1 1 1 DNA methylase Methyltransf_26 PF13659.1 KOO34711.1 - 1.5e-07 31.4 0.0 5.4e-06 26.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO34711.1 - 0.023 15.1 0.0 0.066 13.7 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.13 KOO34711.1 - 0.046 13.2 0.0 0.93 9.0 0.0 2.2 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 Cons_hypoth95 PF03602.10 KOO34711.1 - 0.084 12.2 0.1 0.82 9.0 0.0 2.5 3 0 0 3 3 3 0 Conserved hypothetical protein 95 MTS PF05175.9 KOO34711.1 - 0.11 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_31 PF13847.1 KOO34711.1 - 0.12 11.9 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain TruB_N PF01509.13 KOO34712.1 - 7.3e-47 159.2 0.0 3.2e-46 157.1 0.0 1.8 2 0 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) Kinesin PF00225.18 KOO34713.1 - 9.1e-27 93.6 0.0 1.2e-19 70.2 0.0 3.2 2 1 1 3 3 3 2 Kinesin motor domain DUF4472 PF14739.1 KOO34713.1 - 2e-07 31.4 9.4 2e-07 31.4 6.5 5.8 3 2 4 7 7 7 2 Domain of unknown function (DUF4472) W2 PF02020.13 KOO34714.1 - 8.9e-15 54.4 6.9 3.1e-14 52.6 4.8 2.0 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon NTP_transferase PF00483.18 KOO34714.1 - 2.2e-07 30.4 0.0 5.4e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 KOO34714.1 - 0.00024 21.2 2.4 0.00027 21.0 0.1 2.2 3 0 0 3 3 3 1 MobA-like NTP transferase domain Hexapep PF00132.19 KOO34714.1 - 0.0014 17.9 3.5 0.0014 17.9 2.5 2.9 1 1 2 3 3 3 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 KOO34714.1 - 0.36 10.4 13.3 0.021 14.3 3.3 2.7 1 1 2 3 3 3 0 Hexapeptide repeat of succinyl-transferase Carn_acyltransf PF00755.15 KOO34715.1 - 6.3e-148 493.4 0.0 5.6e-147 490.3 0.0 1.9 1 1 0 1 1 1 1 Choline/Carnitine o-acyltransferase Rer1 PF03248.8 KOO34716.1 - 7e-70 234.1 7.8 8.7e-70 233.8 5.4 1.1 1 0 0 1 1 1 1 Rer1 family EI24 PF07264.6 KOO34716.1 - 0.00042 19.8 5.0 0.00054 19.4 3.5 1.1 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) SecD_SecF PF02355.11 KOO34716.1 - 0.088 11.9 0.4 0.15 11.2 0.0 1.5 2 0 0 2 2 2 0 Protein export membrane protein DUF2208 PF09973.4 KOO34716.1 - 0.23 10.6 6.5 0.16 11.2 2.3 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) ABC_membrane PF00664.18 KOO34716.1 - 0.93 8.8 6.5 0.35 10.2 0.4 2.0 2 0 0 2 2 2 0 ABC transporter transmembrane region Ank_5 PF13857.1 KOO34717.1 - 9.6e-13 47.9 7.9 1.1e-06 28.6 0.1 4.1 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO34717.1 - 8.9e-10 38.7 3.0 6e-05 23.3 0.7 3.3 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO34717.1 - 9.9e-09 34.6 4.9 0.035 14.3 0.0 5.5 6 0 0 6 6 6 3 Ankyrin repeat Ank PF00023.25 KOO34717.1 - 1.2e-08 34.3 10.5 0.045 13.5 0.2 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.1 KOO34717.1 - 1.5e-06 28.5 4.4 0.0013 19.2 0.4 4.6 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Exostosin PF03016.10 KOO34718.1 - 4e-55 186.9 0.0 6e-55 186.4 0.0 1.3 1 0 0 1 1 1 1 Exostosin family EGF_2 PF07974.8 KOO34718.1 - 0.075 13.2 16.4 0.17 12.0 11.4 1.7 1 0 0 1 1 1 0 EGF-like domain Laminin_EGF PF00053.19 KOO34718.1 - 0.15 12.0 8.8 0.23 11.4 3.9 2.4 2 0 0 2 2 2 0 Laminin EGF-like (Domains III and V) Toxin_2 PF00451.14 KOO34718.1 - 3.2 7.9 10.7 22 5.2 0.1 2.4 2 0 0 2 2 2 0 Scorpion short toxin, BmKK2 DUF503 PF04456.7 KOO34720.1 - 0.0051 16.3 6.2 0.016 14.7 4.3 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF503) SRP-alpha_N PF04086.8 KOO34721.1 - 5.4 6.2 8.1 6.6 6.0 5.6 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal RRM_1 PF00076.17 KOO34722.1 - 0.00068 19.2 0.0 0.0015 18.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO34722.1 - 0.0096 15.8 0.0 0.019 14.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Sgf11 PF08209.6 KOO34723.1 - 0.0034 16.6 0.0 0.0065 15.7 0.0 1.5 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) TIR_2 PF13676.1 KOO34724.1 - 6.5e-22 77.6 0.0 7.5e-11 42.0 0.0 3.0 2 0 0 2 2 2 2 TIR domain Pyr_redox_2 PF07992.9 KOO34724.1 - 9e-10 38.7 0.0 5e-09 36.3 0.0 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase TIR PF01582.15 KOO34724.1 - 2e-09 37.0 0.0 5.8e-05 22.5 0.0 2.4 2 0 0 2 2 2 2 TIR domain Pyr_redox PF00070.22 KOO34724.1 - 2.1e-09 37.6 1.5 5.7e-07 29.8 0.0 3.0 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 KOO34724.1 - 0.0022 16.9 0.0 0.047 12.5 0.0 2.2 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Ank PF00023.25 KOO34725.1 - 6.3e-140 448.6 42.0 2e-07 30.4 0.0 18.0 18 0 0 18 18 18 17 Ankyrin repeat Ank_2 PF12796.2 KOO34725.1 - 2.8e-136 444.2 52.3 8.3e-22 77.3 1.2 10.2 1 1 5 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO34725.1 - 9.9e-106 344.4 36.8 4e-09 36.7 0.0 13.6 3 2 14 17 17 17 16 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO34725.1 - 1.2e-91 291.3 15.0 0.00026 20.9 0.0 17.8 17 1 1 18 18 18 17 Ankyrin repeat Ank_5 PF13857.1 KOO34725.1 - 2.4e-67 221.4 43.2 2.7e-07 30.6 0.1 14.9 3 3 11 15 15 15 15 Ankyrin repeats (many copies) Rop-like PF05082.8 KOO34725.1 - 0.00019 20.8 3.6 16 5.0 0.0 6.0 5 2 2 7 7 7 2 Rop-like SseB_C PF14581.1 KOO34725.1 - 0.042 13.7 4.9 89 3.0 0.0 6.0 1 1 4 9 9 9 0 SseB protein C-terminal domain SMP PF04927.7 KOO34725.1 - 0.24 11.4 58.8 16 5.5 0.1 14.9 9 4 6 15 15 15 0 Seed maturation protein DUF2664 PF10867.3 KOO34726.1 - 9.5e-11 42.1 3.3 64 4.2 0.0 10.9 11 2 0 11 11 11 1 Protein of unknown function (DUF2664) Peptidase_C58 PF03543.9 KOO34726.1 - 0.02 14.4 4.2 55 3.1 0.1 6.8 4 3 1 5 5 5 0 Yersinia/Haemophilus virulence surface antigen Pribosyltran PF00156.22 KOO34727.1 - 3.7e-16 58.9 0.5 2.3e-15 56.3 0.4 2.0 1 1 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 KOO34727.1 - 0.028 13.6 0.1 0.041 13.0 0.0 1.1 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Clathrin PF00637.15 KOO34728.1 - 1.2e-17 63.8 0.8 1.2e-07 31.4 0.1 2.4 2 0 0 2 2 2 2 Region in Clathrin and VPS MerR PF00376.18 KOO34728.1 - 0.034 13.7 0.0 0.085 12.4 0.0 1.7 2 0 0 2 2 2 0 MerR family regulatory protein MerR_1 PF13411.1 KOO34728.1 - 0.39 10.5 0.0 1.1 9.1 0.0 1.7 1 0 0 1 1 1 0 MerR HTH family regulatory protein FATC PF02260.15 KOO34730.1 - 0.044 13.2 2.2 0.083 12.3 0.1 2.3 2 0 0 2 2 2 0 FATC domain Ded_cyto PF06920.8 KOO34731.1 - 0.0041 16.4 0.2 0.0041 16.4 0.2 2.0 2 0 0 2 2 2 1 Dedicator of cytokinesis GLE1 PF07817.8 KOO34731.1 - 0.0056 15.6 3.0 0.0056 15.6 2.0 1.7 1 1 1 2 2 2 1 GLE1-like protein TetR_C PF02909.12 KOO34731.1 - 0.021 14.4 1.4 0.049 13.2 0.8 1.8 1 1 0 1 1 1 0 Tetracyclin repressor, C-terminal all-alpha domain Asp23 PF03780.8 KOO34731.1 - 0.034 14.3 0.8 0.071 13.3 0.5 1.5 1 0 0 1 1 1 0 Asp23 family SEA PF01390.15 KOO34731.1 - 0.24 11.0 1.4 0.56 9.9 0.3 2.0 1 1 0 1 1 1 0 SEA domain KxDL PF10241.4 KOO34731.1 - 2.5 8.0 12.1 3.5 7.5 3.4 2.6 2 1 0 2 2 2 0 Uncharacterized conserved protein LOH1CR12 PF10158.4 KOO34731.1 - 9.2 6.0 10.9 8.8 6.1 1.9 2.2 1 1 1 2 2 2 0 Tumour suppressor protein TPR_11 PF13414.1 KOO34732.1 - 2.4e-11 43.0 4.6 3.2e-11 42.7 0.0 2.6 2 1 2 4 4 4 2 TPR repeat TPR_2 PF07719.12 KOO34732.1 - 6e-06 25.7 6.6 0.019 14.8 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO34732.1 - 6.5e-06 25.5 1.2 0.081 12.5 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO34732.1 - 0.043 13.7 9.4 1.6 8.6 1.2 3.8 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.1 KOO34732.1 - 0.11 13.2 21.0 0.34 11.6 4.5 3.8 3 1 1 4 4 4 0 Tetratricopeptide repeat Tex_N PF09371.5 KOO34732.1 - 0.14 11.4 0.0 0.14 11.4 0.0 2.3 2 1 0 2 2 2 0 Tex-like protein N-terminal domain 2OG-FeII_Oxy_3 PF13640.1 KOO34733.1 - 3.3e-12 46.7 0.1 2.6e-11 43.9 0.0 2.1 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO34733.1 - 5.6e-05 23.3 0.0 0.00018 21.7 0.0 1.8 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO34733.1 - 0.0016 17.9 0.0 0.0037 16.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ScpA_ScpB PF02616.9 KOO34734.1 - 0.017 14.7 0.7 0.017 14.7 0.5 2.0 2 0 0 2 2 2 0 ScpA/B protein Ycf1 PF05758.7 KOO34734.1 - 1.8 6.2 3.5 2 6.0 2.4 1.1 1 0 0 1 1 1 0 Ycf1 CutC PF03932.9 KOO34735.1 - 4.5e-65 218.7 0.2 7.1e-65 218.0 0.2 1.3 1 0 0 1 1 1 1 CutC family Glucokinase PF02685.11 KOO34735.1 - 9.4e-58 195.4 0.0 1.5e-57 194.7 0.0 1.3 1 1 0 1 1 1 1 Glucokinase DAO PF01266.19 KOO34737.1 - 6.1e-75 252.3 1.4 8.3e-75 251.9 1.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase GCV_T PF01571.16 KOO34737.1 - 5e-52 176.3 0.0 1.3e-51 174.9 0.0 1.7 2 0 0 2 2 2 1 Aminomethyltransferase folate-binding domain SoxG PF04268.7 KOO34737.1 - 4.2e-10 39.6 0.1 3e-09 36.9 0.0 2.1 2 0 0 2 2 2 1 Sarcosine oxidase, gamma subunit family Trp_halogenase PF04820.9 KOO34737.1 - 1.8e-07 30.1 1.9 2.4e-05 23.1 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase FAD_binding_2 PF00890.19 KOO34737.1 - 2.8e-05 23.1 1.0 0.0051 15.7 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox PF00070.22 KOO34737.1 - 5.5e-05 23.5 0.9 0.016 15.6 0.2 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.11 KOO34737.1 - 0.00024 20.5 0.6 0.002 17.5 0.0 2.3 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA FAD_oxidored PF12831.2 KOO34737.1 - 0.00031 19.9 0.3 0.00077 18.6 0.2 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 KOO34737.1 - 0.00048 20.2 0.2 0.016 15.2 0.1 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GCV_T_C PF08669.6 KOO34737.1 - 0.00099 19.0 0.0 0.051 13.6 0.0 3.0 3 0 0 3 3 3 1 Glycine cleavage T-protein C-terminal barrel domain NAD_binding_8 PF13450.1 KOO34737.1 - 0.0022 17.9 0.3 0.0079 16.1 0.2 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GMC_oxred_N PF00732.14 KOO34737.1 - 0.0031 16.7 0.9 1.7 7.7 0.1 2.2 2 0 0 2 2 2 2 GMC oxidoreductase Thi4 PF01946.12 KOO34737.1 - 0.0038 16.3 1.1 0.34 9.9 0.2 2.2 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.9 KOO34737.1 - 0.004 17.0 0.0 1.1 9.0 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 KOO34737.1 - 0.0075 15.3 1.0 0.04 12.9 0.7 2.0 1 1 0 1 1 1 1 FAD binding domain Shikimate_DH PF01488.15 KOO34737.1 - 0.02 14.9 0.0 0.043 13.9 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.9 KOO34737.1 - 0.021 13.2 0.3 0.043 12.2 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein GIDA PF01134.17 KOO34737.1 - 0.057 12.2 1.0 5.1 5.8 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A ThiF PF00899.16 KOO34737.1 - 0.061 13.1 0.7 0.17 11.6 0.3 1.9 2 0 0 2 2 2 0 ThiF family TrkA_N PF02254.13 KOO34737.1 - 0.082 12.9 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.13 KOO34737.1 - 0.16 11.5 0.1 0.32 10.6 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pkinase PF00069.20 KOO34738.1 - 1.6e-32 112.6 0.0 2.1e-32 112.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34738.1 - 4.5e-19 68.5 0.0 5.8e-19 68.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO34738.1 - 0.00038 19.5 0.1 0.00057 19.0 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO34738.1 - 0.028 14.1 0.2 0.049 13.3 0.1 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO34738.1 - 0.046 12.6 0.0 0.066 12.1 0.0 1.1 1 0 0 1 1 1 0 Kinase-like LRR_6 PF13516.1 KOO34739.1 - 0.052 13.6 0.0 0.32 11.1 0.0 2.2 3 0 0 3 3 3 0 Leucine Rich repeat IQ PF00612.22 KOO34740.1 - 2.4e-05 23.5 4.0 0.0023 17.3 1.1 2.9 2 0 0 2 2 2 2 IQ calmodulin-binding motif TolA PF06519.6 KOO34740.1 - 0.00051 19.9 5.0 3.7 7.5 0.2 3.5 1 1 2 3 3 3 3 TolA C-terminal RVT_2 PF07727.9 KOO34741.1 - 4.5e-36 124.0 0.0 6.5e-36 123.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF3638 PF12340.3 KOO34742.1 - 3.6e-20 71.9 0.5 6.9e-20 71.0 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.3 KOO34742.1 - 6.7e-16 57.1 0.2 6.7e-16 57.1 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3645) IQ PF00612.22 KOO34743.1 - 0.00049 19.4 0.2 0.0017 17.8 0.1 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif PCMT PF01135.14 KOO34744.1 - 7.7e-19 68.0 0.0 1.6e-18 67.0 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 KOO34744.1 - 1.5e-11 44.1 0.0 2.8e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain APC10 PF03256.11 KOO34744.1 - 4.7e-10 39.3 0.0 8.9e-07 28.6 0.0 2.3 2 0 0 2 2 2 2 Anaphase-promoting complex, subunit 10 (APC10) Methyltransf_18 PF12847.2 KOO34744.1 - 3.5e-07 30.7 0.1 1.6e-06 28.6 0.0 2.2 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.9 KOO34744.1 - 4.2e-06 26.2 0.1 1.2e-05 24.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_25 PF13649.1 KOO34744.1 - 7.1e-06 26.3 0.0 1.9e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO34744.1 - 5.7e-05 22.3 0.0 0.0001 21.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family F5_F8_type_C PF00754.20 KOO34744.1 - 0.01 15.6 0.5 0.17 11.7 0.2 2.8 3 0 0 3 3 3 0 F5/8 type C domain DOT1 PF08123.8 KOO34744.1 - 0.027 13.7 0.0 0.047 13.0 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 RrnaAD PF00398.15 KOO34744.1 - 0.043 12.8 0.0 0.075 12.0 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase CMAS PF02353.15 KOO34744.1 - 0.06 12.4 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase GCD14 PF08704.5 KOO34744.1 - 0.14 11.6 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Peptidase_M41 PF01434.13 KOO34744.1 - 0.82 9.1 0.6 1.5 8.2 0.0 1.6 2 0 0 2 2 2 0 Peptidase family M41 Glyco_hydro_7 PF00840.15 KOO34745.1 - 2.8e-138 460.9 7.1 2.8e-138 460.9 4.9 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 7 PH PF00169.24 KOO34746.1 - 9.9e-10 38.5 0.0 0.0037 17.4 0.0 3.6 3 1 0 3 3 3 2 PH domain PH_9 PF15410.1 KOO34746.1 - 9.3e-06 25.7 0.1 3.8 7.6 0.0 3.5 3 0 0 3 3 3 3 Pleckstrin homology domain IncFII_repA PF02387.10 KOO34746.1 - 0.87 8.6 12.4 1.5 7.9 8.6 1.3 1 0 0 1 1 1 0 IncFII RepA protein family TPR_12 PF13424.1 KOO34747.1 - 7.2e-160 519.3 30.5 4.3e-20 71.4 0.0 6.4 1 1 8 9 9 9 9 Tetratricopeptide repeat TPR_10 PF13374.1 KOO34747.1 - 2.4e-119 386.3 36.5 2.6e-14 52.5 0.1 10.0 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_1 PF00515.23 KOO34747.1 - 4.5e-44 146.3 4.4 5.8e-05 22.5 0.1 10.1 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_2 PF07719.12 KOO34747.1 - 1.2e-41 137.3 8.0 0.0027 17.5 0.1 10.2 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_16 PF13432.1 KOO34747.1 - 1.7e-39 133.6 18.8 1.5e-07 31.8 0.1 7.6 2 2 6 8 8 8 8 Tetratricopeptide repeat TPR_7 PF13176.1 KOO34747.1 - 1.4e-35 118.2 21.9 0.0014 18.2 0.0 10.2 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_8 PF13181.1 KOO34747.1 - 8.5e-35 115.9 5.4 0.0041 16.7 0.0 10.2 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_4 PF07721.9 KOO34747.1 - 5e-32 106.9 11.2 0.093 13.2 0.0 10.7 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_11 PF13414.1 KOO34747.1 - 8e-32 108.7 10.6 7e-07 28.8 0.1 6.6 2 2 5 8 8 8 7 TPR repeat TPR_17 PF13431.1 KOO34747.1 - 5.6e-24 82.2 10.7 0.13 12.5 0.0 10.4 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_19 PF14559.1 KOO34747.1 - 4e-23 81.5 27.0 2.7e-05 24.4 1.2 6.5 4 2 1 6 6 6 5 Tetratricopeptide repeat TPR_14 PF13428.1 KOO34747.1 - 7.1e-23 79.0 35.5 0.024 15.2 0.1 10.3 3 2 7 10 10 10 8 Tetratricopeptide repeat Apc3 PF12895.2 KOO34747.1 - 8.6e-11 41.8 0.0 0.23 11.5 0.0 5.4 2 2 5 7 7 7 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 KOO34747.1 - 1.7e-10 40.6 13.2 9.3 6.9 0.0 10.1 10 0 0 10 10 10 0 Tetratricopeptide repeat HisKA_3 PF07730.8 KOO34747.1 - 1.2e-09 38.3 23.9 1.1 9.6 0.0 9.2 7 3 3 10 10 10 1 Histidine kinase ApoLp-III PF07464.6 KOO34747.1 - 1.3e-09 38.2 9.3 0.37 10.8 0.1 7.0 2 2 6 8 8 8 3 Apolipophorin-III precursor (apoLp-III) TPR_5 PF12688.2 KOO34747.1 - 4.9e-09 36.2 20.9 0.015 15.3 0.5 5.4 1 1 5 6 6 6 4 Tetratrico peptide repeat Osmo_CC PF08946.5 KOO34747.1 - 5.2e-07 29.5 10.3 19 5.3 0.0 9.9 9 3 1 10 10 10 0 Osmosensory transporter coiled coil TPR_3 PF07720.7 KOO34747.1 - 7.9e-07 28.7 0.0 4 7.3 0.0 7.6 9 0 0 9 9 9 1 Tetratricopeptide repeat Rab5-bind PF09311.6 KOO34747.1 - 0.0012 18.7 0.7 21 4.9 0.0 4.8 2 2 2 5 5 5 0 Rabaptin-like protein DUF3368 PF11848.3 KOO34747.1 - 0.0026 17.2 13.5 2.7 7.6 0.2 8.0 9 0 0 9 9 9 1 Domain of unknown function (DUF3368) DUF1858 PF08984.6 KOO34747.1 - 0.0039 16.8 0.0 41 3.9 0.0 5.4 6 0 0 6 6 6 0 Domain of unknown function (DUF1858) V-SNARE_C PF12352.3 KOO34747.1 - 0.0042 17.1 2.0 22 5.2 0.0 6.2 7 1 1 8 8 8 0 Snare region anchored in the vesicle membrane C-terminus RPN7 PF10602.4 KOO34747.1 - 0.0058 16.0 0.0 19 4.5 0.0 4.7 3 2 3 6 6 6 0 26S proteasome subunit RPN7 DUF832 PF05734.6 KOO34747.1 - 0.0068 15.6 0.1 13 4.8 0.0 4.4 4 1 2 6 6 6 0 Herpesvirus protein of unknown function (DUF832) PPR_1 PF12854.2 KOO34747.1 - 0.015 14.7 11.6 17 4.9 0.0 7.9 9 0 0 9 9 9 0 PPR repeat TPR_21 PF09976.4 KOO34747.1 - 0.026 14.4 15.0 3.2 7.6 0.3 5.6 1 1 2 4 4 4 0 Tetratricopeptide repeat DUF3366 PF11846.3 KOO34747.1 - 0.065 13.1 2.6 9.1 6.0 0.1 4.1 1 1 1 4 4 4 0 Domain of unknown function (DUF3366) DUF4404 PF14357.1 KOO34747.1 - 0.07 13.5 7.4 41 4.6 0.1 4.9 4 2 1 5 5 5 0 Domain of unknown function (DUF4404) HEAT_PBS PF03130.11 KOO34747.1 - 0.2 12.2 30.1 36 5.2 0.1 9.3 10 0 0 10 10 9 0 PBS lyase HEAT-like repeat BT1 PF03092.11 KOO34748.1 - 1.6e-50 172.1 22.5 4.2e-50 170.7 15.6 1.6 1 1 0 1 1 1 1 BT1 family Ecm29 PF13001.2 KOO34749.1 - 1.7e-51 175.2 0.0 6.7e-32 110.6 0.0 3.1 1 1 2 3 3 3 2 Proteasome stabiliser CLASP_N PF12348.3 KOO34749.1 - 0.0025 17.2 0.1 3.2 7.0 0.0 3.2 2 1 1 3 3 3 2 CLASP N terminal Cnd1 PF12717.2 KOO34749.1 - 0.0031 17.3 0.0 3 7.6 0.0 4.1 4 1 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 KOO34749.1 - 0.021 14.8 28.4 7.3 6.9 0.0 11.2 13 0 0 13 13 13 0 HEAT repeat Adaptin_N PF01602.15 KOO34749.1 - 0.029 12.7 0.0 3.9 5.6 0.0 3.4 2 1 0 3 3 3 0 Adaptin N terminal region HEAT_EZ PF13513.1 KOO34749.1 - 0.052 14.0 0.3 0.075 13.5 0.2 14.8 13 4 1 14 14 14 0 HEAT-like repeat TnpV PF14198.1 KOO34750.1 - 0.0077 16.1 0.2 0.0077 16.1 0.2 2.9 2 1 1 3 3 3 1 Transposon-encoded protein TnpV Peripla_BP_2 PF01497.13 KOO34750.1 - 0.026 13.6 3.4 0.087 11.9 2.4 2.0 1 1 0 1 1 1 0 Periplasmic binding protein Ion_trans PF00520.26 KOO34751.1 - 5.3e-17 61.7 5.9 9.8e-17 60.8 4.1 1.4 1 1 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO34751.1 - 7.7e-07 28.7 5.1 7.7e-07 28.7 3.5 3.4 3 1 1 4 4 4 1 Ion channel EF-hand_1 PF00036.27 KOO34752.1 - 2.6e-24 82.6 1.9 4.8e-06 25.4 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO34752.1 - 8.5e-23 78.1 1.1 1.4e-06 27.6 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO34752.1 - 1.9e-20 72.7 3.5 4.7e-12 45.8 0.0 3.1 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO34752.1 - 2.2e-17 62.3 7.6 7.3e-06 25.4 2.1 4.6 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO34752.1 - 5.7e-17 60.2 10.3 3.8e-05 22.8 0.0 4.9 5 0 0 5 5 5 4 EF hand EF-hand_4 PF12763.2 KOO34752.1 - 0.0018 17.9 0.1 1.1 9.0 0.1 2.4 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 KOO34752.1 - 0.004 17.0 0.1 0.027 14.3 0.0 2.4 2 1 2 4 4 4 1 EF-hand domain EF-hand_like PF09279.6 KOO34752.1 - 0.011 15.7 2.0 1.8 8.6 0.0 3.2 3 1 0 3 3 3 0 Phosphoinositide-specific phospholipase C, efhand-like SPARC_Ca_bdg PF10591.4 KOO34752.1 - 0.036 14.0 1.5 9.3 6.3 0.1 3.3 3 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region GCIP PF13324.1 KOO34752.1 - 0.094 11.9 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Selenoprotein_S PF06936.6 KOO34752.1 - 1.2 8.6 12.9 0.037 13.5 4.1 1.9 2 0 0 2 2 2 0 Selenoprotein S (SelS) Spc7 PF08317.6 KOO34752.1 - 3 6.4 9.4 11 4.5 0.1 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein EF-hand_1 PF00036.27 KOO34753.1 - 0.0039 16.3 0.0 0.035 13.4 0.0 2.3 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO34753.1 - 0.012 15.6 0.0 0.095 12.8 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.1 KOO34753.1 - 0.034 13.5 0.0 0.11 11.8 0.0 2.0 1 0 0 1 1 1 0 EF hand EF-hand_8 PF13833.1 KOO34753.1 - 0.055 13.0 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_4 PF12763.2 KOO34753.1 - 0.14 11.9 0.0 0.29 10.8 0.0 1.4 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Ank_5 PF13857.1 KOO34756.1 - 2.8e-25 87.7 9.3 8e-10 38.6 0.1 4.3 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.25 KOO34756.1 - 6.7e-20 69.8 4.1 0.00013 21.5 0.0 4.5 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.1 KOO34756.1 - 2.6e-19 67.3 1.6 0.00021 21.1 0.0 4.5 4 0 0 4 4 4 4 Ankyrin repeat Ank_2 PF12796.2 KOO34756.1 - 1.2e-18 67.2 10.2 9.7e-09 35.4 0.2 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO34756.1 - 1.9e-18 66.4 0.3 1.1e-07 32.2 0.1 3.4 3 0 0 3 3 3 3 Ankyrin repeats (many copies) DUF1930 PF09122.5 KOO34756.1 - 0.04 13.6 0.0 0.16 11.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1930) TonB_C PF03544.9 KOO34756.1 - 0.053 13.7 1.2 13 6.0 0.0 3.9 4 0 0 4 4 4 0 Gram-negative bacterial TonB protein C-terminal Omptin PF01278.15 KOO34756.1 - 0.12 11.4 0.5 1 8.4 0.1 2.4 1 1 2 3 3 3 0 Omptin family FCD PF07729.7 KOO34756.1 - 0.12 12.6 5.3 2.1 8.6 0.1 3.3 2 1 0 2 2 2 0 FCD domain Arm PF00514.18 KOO34757.1 - 4e-70 229.4 59.8 2.4e-08 33.4 0.2 14.1 13 1 0 13 13 13 12 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 KOO34757.1 - 7.2e-24 84.2 7.0 7.7e-05 21.9 0.0 6.7 2 2 5 8 8 8 7 Armadillo-like Atx10homo_assoc PF09759.4 KOO34757.1 - 1.6e-08 34.1 12.2 0.33 10.6 0.6 8.5 6 4 3 9 9 9 5 Spinocerebellar ataxia type 10 protein domain U-box PF04564.10 KOO34757.1 - 5.7e-08 32.6 0.0 1.1e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO34757.1 - 0.00019 20.8 0.0 0.00038 19.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 KOO34757.1 - 0.023 14.4 0.0 0.061 13.0 0.0 1.7 1 0 0 1 1 1 0 RING-type zinc-finger Antiterm PF03589.8 KOO34757.1 - 0.027 14.5 0.1 4 7.5 0.0 3.6 3 0 0 3 3 3 0 Antitermination protein V-ATPase_H_N PF03224.9 KOO34757.1 - 0.035 13.2 0.0 9.6 5.2 0.0 3.1 1 1 2 3 3 3 0 V-ATPase subunit H Rhodanese PF00581.15 KOO34758.1 - 8.3e-08 32.5 0.0 1.7e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Gly-zipper_OmpA PF13436.1 KOO34758.1 - 6.1 6.5 8.2 3.3 7.3 4.1 1.7 2 0 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain EF-hand_1 PF00036.27 KOO34759.1 - 1.1e-19 68.1 15.4 1.5e-06 27.1 0.2 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO34759.1 - 1.6e-18 64.8 9.0 9.9e-06 25.0 0.3 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO34759.1 - 1.3e-17 63.7 11.9 2.9e-09 36.9 1.3 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO34759.1 - 7.5e-16 56.6 5.9 2e-07 30.0 0.5 4.3 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO34759.1 - 2.8e-14 52.4 19.4 2.7e-06 26.9 1.5 3.8 2 2 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO34759.1 - 0.0043 17.0 9.1 0.075 13.0 2.6 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Cbl_N2 PF02761.9 KOO34759.1 - 0.12 12.4 0.0 1.4 9.0 0.0 2.1 2 0 0 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain Laps PF10169.4 KOO34759.1 - 6.1 7.0 8.2 1 9.5 2.3 2.1 1 1 1 2 2 2 0 Learning-associated protein EF-hand_4 PF12763.2 KOO34759.1 - 8.4 6.1 11.9 4.1 7.2 0.1 3.6 1 1 3 4 4 4 0 Cytoskeletal-regulatory complex EF hand EFP_N PF08207.7 KOO34761.1 - 1.5e-24 85.6 0.0 2.7e-24 84.7 0.0 1.5 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain Elong-fact-P_C PF09285.6 KOO34761.1 - 2.9e-21 74.5 0.5 6.2e-21 73.5 0.4 1.6 1 0 0 1 1 1 1 Elongation factor P, C-terminal EFP PF01132.15 KOO34761.1 - 1.7e-17 62.8 1.9 1.7e-17 62.8 1.3 1.7 2 0 0 2 2 2 1 Elongation factor P (EF-P) OB domain Propeptide_C1 PF08127.8 KOO34761.1 - 0.033 13.7 0.0 0.068 12.7 0.0 1.4 1 0 0 1 1 1 0 Peptidase family C1 propeptide PAS_9 PF13426.1 KOO34762.1 - 1.1e-33 115.7 0.0 2.9e-16 59.7 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS PF00989.19 KOO34762.1 - 7.5e-09 35.3 0.0 9.9e-05 22.0 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_8 PF13188.1 KOO34762.1 - 2.3e-07 30.4 0.0 0.00043 20.0 0.0 3.4 3 0 0 3 3 3 2 PAS domain PAS_3 PF08447.6 KOO34762.1 - 0.0023 17.9 0.0 0.058 13.5 0.0 2.5 2 0 0 2 2 2 1 PAS fold PAS_4 PF08448.5 KOO34762.1 - 0.023 14.7 5.0 0.047 13.7 0.1 3.1 4 0 0 4 4 4 0 PAS fold Rhomboid_SP PF12595.3 KOO34764.1 - 0.096 12.2 3.8 0.11 12.1 2.6 1.2 1 0 0 1 1 1 0 Rhomboid serine protease Pkinase PF00069.20 KOO34765.1 - 3.9e-53 180.2 0.0 4.5e-53 180.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34765.1 - 2.1e-21 76.1 0.0 2.7e-21 75.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO34765.1 - 4.4e-07 29.1 0.0 3.3e-05 22.9 0.0 2.4 2 1 0 2 2 2 1 Kinase-like APH PF01636.18 KOO34765.1 - 8.1e-07 29.0 0.1 2.8e-06 27.2 0.1 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 KOO34765.1 - 0.00011 21.5 0.0 0.0002 20.7 0.0 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Choline_kinase PF01633.15 KOO34765.1 - 0.0022 17.6 0.0 0.0031 17.1 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.9 KOO34765.1 - 0.0057 15.7 0.0 0.0088 15.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pex19 PF04614.7 KOO34766.1 - 2.9e-33 115.5 4.2 5.1e-29 101.6 0.0 2.5 2 1 0 2 2 2 2 Pex19 protein family GET2 PF08690.5 KOO34766.1 - 0.091 11.9 0.0 0.15 11.2 0.0 1.5 1 0 0 1 1 1 0 GET complex subunit GET2 HEAT PF02985.17 KOO34767.1 - 0.09 12.8 0.8 11 6.4 0.0 3.3 3 0 0 3 3 3 0 HEAT repeat fn3 PF00041.16 KOO34768.1 - 8.5e-15 54.6 0.0 1.9e-10 40.7 0.0 2.3 1 1 1 2 2 2 2 Fibronectin type III domain SHIPPO-rpt PF07004.7 KOO34768.1 - 2.5e-05 24.9 12.3 0.015 16.1 0.1 3.9 5 0 0 5 5 5 2 Sperm-tail PG-rich repeat UCH PF00443.24 KOO34769.1 - 3.3e-43 147.7 0.0 4.5e-43 147.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOO34769.1 - 1.2e-20 74.1 0.0 2.1e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rad60-SLD_2 PF13881.1 KOO34769.1 - 7.8e-05 22.5 0.0 0.00016 21.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 KOO34769.1 - 0.029 13.7 0.0 0.058 12.8 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family DUF4391 PF14335.1 KOO34769.1 - 5.5 6.3 0.0 9.1 5.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) Neur_chan_memb PF02932.11 KOO34770.1 - 2.4e-06 27.5 0.2 3.8e-06 26.9 0.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region KASH PF10541.4 KOO34771.1 - 0.022 14.5 2.2 0.047 13.5 1.5 1.5 1 0 0 1 1 1 0 Nuclear envelope localisation domain PH PF00169.24 KOO34772.1 - 4.9e-18 65.2 0.0 1.2e-17 64.0 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.1 KOO34772.1 - 1.1e-08 35.2 0.1 1.1e-06 28.8 0.1 2.8 1 1 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.1 KOO34772.1 - 0.0013 18.9 0.0 0.0052 16.9 0.0 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain Syntaxin PF00804.20 KOO34772.1 - 0.0089 16.1 1.5 0.0089 16.1 1.0 2.5 2 1 0 2 2 2 1 Syntaxin AAA_23 PF13476.1 KOO34772.1 - 0.81 9.9 6.9 0.13 12.5 0.9 2.0 2 0 0 2 2 2 0 AAA domain Hydrolase PF00702.21 KOO34773.1 - 1.2e-07 32.3 0.0 7.3e-07 29.8 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 KOO34773.1 - 1.8e-05 25.0 0.0 0.0059 16.8 0.0 2.4 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO34773.1 - 0.00015 22.0 0.0 0.00036 20.7 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOO34773.1 - 0.00016 21.3 0.5 0.0039 16.8 0.3 2.5 1 1 0 1 1 1 1 HAD-hyrolase-like DUF2828 PF11443.3 KOO34774.1 - 7.2e-98 328.1 0.0 5e-84 282.4 0.0 3.0 1 1 1 2 2 2 2 Domain of unknown function (DUF2828) VWA_CoxE PF05762.9 KOO34774.1 - 3.6e-07 29.5 0.0 7.4e-07 28.5 0.0 1.5 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein VWA_3 PF13768.1 KOO34774.1 - 0.0056 16.3 0.1 0.049 13.3 0.0 2.6 2 1 0 2 2 2 1 von Willebrand factor type A domain Arm PF00514.18 KOO34775.1 - 9.4e-08 31.6 8.6 0.0036 17.0 0.0 5.8 5 1 0 5 5 5 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO34775.1 - 7.3e-07 29.3 7.3 0.003 17.8 0.1 3.3 3 0 0 3 3 3 2 HEAT repeats RICTOR_V PF14668.1 KOO34775.1 - 0.00055 19.8 0.4 0.031 14.2 0.0 2.6 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, domain 5 HEAT PF02985.17 KOO34775.1 - 0.047 13.7 11.9 1.5 9.1 0.1 5.6 5 0 0 5 5 5 0 HEAT repeat Neurochondrin PF05536.6 KOO34775.1 - 0.051 11.8 0.5 1.2 7.3 0.0 2.4 1 1 0 2 2 2 0 Neurochondrin HEAT_EZ PF13513.1 KOO34775.1 - 5.9 7.5 14.1 0.11 13.0 0.6 4.1 3 2 2 5 5 5 0 HEAT-like repeat Ion_trans_2 PF07885.11 KOO34776.1 - 5e-19 67.7 18.4 6.5e-13 48.2 4.4 2.5 2 0 0 2 2 2 2 Ion channel EF-hand_7 PF13499.1 KOO34776.1 - 3e-12 46.4 0.0 7.5e-12 45.2 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO34776.1 - 2.9e-11 41.8 0.3 0.00038 19.5 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO34776.1 - 2.7e-10 39.1 0.4 0.00056 19.1 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO34776.1 - 9.3e-09 34.4 0.1 0.0012 18.5 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO34776.1 - 3.6e-07 29.7 0.0 8.5e-07 28.4 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_9 PF14658.1 KOO34776.1 - 0.0015 18.3 0.0 0.003 17.4 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain Ion_trans PF00520.26 KOO34776.1 - 0.033 13.4 12.8 0.14 11.4 1.3 2.4 2 0 0 2 2 2 0 Ion transport protein Leukocidin PF07968.7 KOO34777.1 - 0.051 13.2 1.2 2.7 7.5 0.1 2.3 2 0 0 2 2 2 0 Leukocidin/Hemolysin toxin family YL1 PF05764.8 KOO34778.1 - 3.3 7.2 7.0 4.8 6.7 4.8 1.1 1 0 0 1 1 1 0 YL1 nuclear protein UDPG_MGDP_dh_N PF03721.9 KOO34780.1 - 7.1e-27 93.9 0.0 9.5e-27 93.5 0.0 1.1 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.14 KOO34780.1 - 6.1e-13 48.7 0.2 4.1e-06 26.9 0.0 2.4 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, central domain ApbA PF02558.11 KOO34780.1 - 0.0012 18.2 0.0 0.0019 17.6 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.13 KOO34780.1 - 0.0014 18.3 0.1 0.0022 17.7 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.18 KOO34780.1 - 0.0089 15.7 0.0 0.018 14.7 0.0 1.6 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus AlaDh_PNT_C PF01262.16 KOO34780.1 - 0.12 11.9 0.4 0.24 10.9 0.1 1.6 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain SBBP PF06739.6 KOO34781.1 - 2.5e-10 39.9 63.0 0.0008 19.1 1.2 7.3 7 0 0 7 7 7 6 Beta-propeller repeat NMU PF02070.10 KOO34781.1 - 4.7 6.8 14.0 45 3.6 0.1 6.0 6 0 0 6 6 6 0 Neuromedin U UPF0016 PF01169.14 KOO34782.1 - 4.4e-35 119.6 25.4 1e-18 67.2 4.2 3.1 3 0 0 3 3 3 2 Uncharacterized protein family UPF0016 Pantoate_transf PF02548.10 KOO34782.1 - 0.0074 15.4 0.1 0.011 14.8 0.1 1.2 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase Filamin PF00630.14 KOO34783.1 - 1.1e-34 118.9 0.0 5.4e-07 30.1 0.0 7.6 5 2 1 6 6 6 6 Filamin/ABP280 repeat C2 PF00168.25 KOO34783.1 - 1.6e-13 50.3 0.0 4.2e-13 48.9 0.0 1.8 1 0 0 1 1 1 1 C2 domain Big_1 PF02369.11 KOO34783.1 - 8.7e-07 28.7 1.4 0.17 11.8 0.1 4.4 3 1 1 4 4 4 2 Bacterial Ig-like domain (group 1) PWWP PF00855.12 KOO34784.1 - 7.6e-07 29.2 0.1 1.9e-06 27.9 0.0 1.8 2 0 0 2 2 2 1 PWWP domain LRR_6 PF13516.1 KOO34787.1 - 5.3e-14 50.6 6.1 5e-05 22.9 0.0 5.0 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.2 KOO34787.1 - 0.022 14.3 0.2 3.1 7.5 0.0 2.9 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO34787.1 - 0.04 13.9 0.0 31 5.1 0.0 3.7 3 0 0 3 3 3 0 Leucine Rich Repeat SpoU_sub_bind PF08032.7 KOO34787.1 - 0.18 11.9 0.4 1.9 8.6 0.0 2.4 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding WD40 PF00400.27 KOO34788.1 - 4.2e-89 289.5 28.4 2.1e-12 46.3 0.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat PD40 PF07676.7 KOO34788.1 - 2.7e-17 62.0 6.7 0.53 10.0 0.0 7.5 7 0 0 7 7 7 7 WD40-like Beta Propeller Repeat DUF3312 PF11768.3 KOO34788.1 - 9.7e-08 30.6 0.0 0.081 11.1 0.0 4.1 2 1 3 5 5 5 4 Protein of unknown function (DUF3312) Nbas_N PF15492.1 KOO34788.1 - 3.1e-07 29.7 7.5 1.8 7.5 0.6 5.4 1 1 3 4 4 4 4 Neuroblastoma-amplified sequence, N terminal IKI3 PF04762.7 KOO34788.1 - 1.2e-06 26.6 0.0 0.038 11.8 0.0 3.8 2 1 3 5 5 5 2 IKI3 family DUF1513 PF07433.6 KOO34788.1 - 3.7e-06 26.0 0.8 0.56 9.0 0.0 4.9 1 1 3 5 5 5 1 Protein of unknown function (DUF1513) Nucleoporin_N PF08801.6 KOO34788.1 - 8.1e-06 24.8 5.9 0.37 9.4 0.1 5.1 1 1 4 5 5 5 2 Nup133 N terminal like Nup160 PF11715.3 KOO34788.1 - 0.00011 20.4 8.2 5.1 5.1 0.4 5.6 2 2 5 7 7 7 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.11 KOO34788.1 - 0.0003 19.2 2.0 1.7 6.8 0.0 3.6 1 1 3 4 4 4 2 Cytochrome D1 heme domain Gmad1 PF10647.4 KOO34788.1 - 0.00047 19.6 0.4 2.2 7.6 0.1 5.3 2 2 1 3 3 3 1 Lipoprotein LpqB beta-propeller domain MORN_2 PF07661.8 KOO34788.1 - 0.11 12.5 0.0 9.9 6.5 0.0 3.7 4 0 0 4 4 3 0 MORN repeat variant Flt3_lig PF02947.9 KOO34788.1 - 0.13 12.1 0.0 7.9 6.3 0.0 3.5 4 1 1 5 5 5 0 flt3 ligand rOmpB PF12334.3 KOO34788.1 - 0.14 11.4 5.4 19 4.5 0.0 5.0 5 2 0 6 6 6 0 Rickettsia outer membrane protein B Ank_2 PF12796.2 KOO34789.1 - 2e-09 37.6 0.1 7.9e-09 35.7 0.1 2.0 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO34789.1 - 9.3e-08 31.5 5.3 0.00074 19.2 0.2 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.1 KOO34789.1 - 5.8e-06 26.0 0.8 0.11 12.7 0.0 4.0 3 0 0 3 3 3 1 Ankyrin repeat EF-hand_6 PF13405.1 KOO34789.1 - 6.8e-06 25.5 0.2 0.3 11.1 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain Ank_5 PF13857.1 KOO34789.1 - 9.1e-06 25.7 2.9 0.0068 16.6 0.2 3.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO34789.1 - 1.5e-05 25.3 0.3 0.0023 18.3 0.3 2.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Laminin_G_3 PF13385.1 KOO34789.1 - 0.0001 22.5 0.2 0.00019 21.7 0.1 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily EF-hand_1 PF00036.27 KOO34789.1 - 0.00039 19.5 0.0 1.3 8.4 0.0 3.6 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.1 KOO34789.1 - 0.002 18.2 0.2 2.9 8.1 0.0 3.0 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO34789.1 - 0.036 13.4 0.9 8.8 5.8 0.0 3.3 3 0 0 3 3 3 0 EF hand Toxin_R_bind_N PF07953.7 KOO34789.1 - 0.29 10.5 0.0 0.49 9.8 0.0 1.2 1 0 0 1 1 1 0 Clostridium neurotoxin, N-terminal receptor binding PaO PF08417.7 KOO34790.1 - 6e-14 51.7 0.1 2e-13 50.0 0.1 1.9 1 1 0 1 1 1 1 Pheophorbide a oxygenase ATG16 PF08614.6 KOO34792.1 - 0.002 17.9 5.3 0.002 17.9 3.7 5.7 2 1 3 6 6 6 1 Autophagy protein 16 (ATG16) TMF_TATA_bd PF12325.3 KOO34792.1 - 0.0036 17.0 4.0 0.0036 17.0 2.8 7.4 4 3 2 6 6 6 2 TATA element modulatory factor 1 TATA binding Galactosyl_T PF01762.16 KOO34793.1 - 8.3e-07 28.7 0.0 2.6e-06 27.1 0.0 1.8 2 1 0 2 2 2 1 Galactosyltransferase EF-hand_6 PF13405.1 KOO34793.1 - 0.00071 19.2 0.5 0.13 12.2 0.1 3.3 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.27 KOO34793.1 - 0.00084 18.4 0.4 0.065 12.5 0.2 3.2 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.1 KOO34793.1 - 0.00085 18.8 1.0 0.55 9.8 0.0 3.4 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.1 KOO34793.1 - 0.0094 16.0 0.1 0.52 10.4 0.1 2.7 2 1 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO34793.1 - 0.36 10.2 4.8 2.1 7.8 0.2 3.5 4 0 0 4 4 4 0 EF hand HrpB7 PF09486.5 KOO34794.1 - 0.023 14.6 2.4 0.023 14.6 1.7 2.4 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) Apc5 PF12862.2 KOO34794.1 - 0.082 12.7 0.1 0.082 12.7 0.1 1.8 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 5 CDC37_N PF03234.9 KOO34794.1 - 0.084 13.1 7.3 0.12 12.6 4.9 1.4 1 1 0 1 1 1 0 Cdc37 N terminal kinase binding PP_kinase_N PF13089.1 KOO34794.1 - 0.14 12.2 1.9 0.34 11.0 1.3 1.7 1 0 0 1 1 1 0 Polyphosphate kinase N-terminal domain Cellulose_synt PF03552.9 KOO34794.1 - 0.28 9.4 2.2 0.32 9.2 1.6 1.0 1 0 0 1 1 1 0 Cellulose synthase RhoGAP PF00620.22 KOO34794.1 - 0.48 10.0 4.1 0.48 10.0 0.0 2.5 1 1 0 2 2 2 0 RhoGAP domain PLRV_ORF5 PF01690.12 KOO34794.1 - 0.53 9.3 5.2 0.57 9.2 3.6 1.0 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein OEP PF02321.13 KOO34794.1 - 3 7.4 10.8 6.8 6.2 1.2 2.4 2 0 0 2 2 2 0 Outer membrane efflux protein COG2 PF06148.6 KOO34794.1 - 4.1 7.2 8.5 0.7 9.7 0.1 2.2 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Vps16_C PF04840.7 KOO34795.1 - 8.9e-27 93.8 0.0 2.9e-25 88.9 0.0 2.0 2 0 0 2 2 2 1 Vps16, C-terminal region Kelch_3 PF13415.1 KOO34795.1 - 5.4e-10 39.1 8.4 0.0033 17.5 0.0 5.7 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KOO34795.1 - 6.4e-10 38.6 16.6 0.0019 17.8 0.1 6.0 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_2 PF07646.10 KOO34795.1 - 1.6e-08 33.9 2.0 0.1 12.4 0.1 4.8 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.20 KOO34795.1 - 1.4e-07 30.9 0.3 0.0012 18.3 0.1 3.8 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.1 KOO34795.1 - 1.9e-07 30.9 7.6 0.0055 16.8 0.5 4.5 3 1 1 4 4 4 2 Kelch motif Kelch_5 PF13854.1 KOO34795.1 - 2.3e-07 30.6 5.0 0.0029 17.5 0.1 4.8 5 0 0 5 5 5 2 Kelch motif SAP PF02037.22 KOO34796.1 - 1.9e-07 30.4 6.2 1.6e-05 24.3 0.1 2.4 2 0 0 2 2 2 2 SAP domain AP2 PF00847.15 KOO34796.1 - 0.00083 19.4 40.5 0.029 14.5 0.1 7.9 7 2 0 7 7 7 3 AP2 domain YppG PF14179.1 KOO34797.1 - 0.053 14.1 1.4 0.079 13.5 1.0 1.4 1 0 0 1 1 1 0 YppG-like protein Herpes_UL32 PF06070.6 KOO34797.1 - 0.13 10.6 1.7 0.15 10.5 1.2 1.0 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 TMF_DNA_bd PF12329.3 KOO34800.1 - 0.00074 19.2 1.6 0.00074 19.2 1.1 3.7 2 2 2 4 4 4 1 TATA element modulatory factor 1 DNA binding CENP-F_leu_zip PF10473.4 KOO34800.1 - 0.0021 17.9 3.5 0.0021 17.9 2.4 2.8 1 1 2 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Peptidase_S7 PF00949.16 KOO34800.1 - 0.0061 15.9 0.1 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase S7, Flavivirus NS3 serine protease DUF1768 PF08719.6 KOO34800.1 - 2.3 7.9 13.8 0.1 12.3 4.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1768) Exostosin PF03016.10 KOO34801.1 - 4e-20 72.0 0.0 1.6e-19 70.0 0.0 1.8 1 1 0 1 1 1 1 Exostosin family Ion_trans PF00520.26 KOO34803.1 - 7.4e-102 338.7 45.2 2.4e-38 131.3 6.9 3.5 4 0 0 4 4 4 3 Ion transport protein PKD_channel PF08016.7 KOO34803.1 - 3.9e-07 28.8 3.9 3.9e-07 28.8 2.7 5.9 6 1 1 7 7 7 3 Polycystin cation channel Lustrin_cystein PF14625.1 KOO34803.1 - 0.22 11.6 0.5 0.52 10.4 0.3 1.5 1 0 0 1 1 1 0 Lustrin, cysteine-rich repeated domain PAN_2 PF08276.6 KOO34804.1 - 5.6 6.8 6.8 10 6.0 0.9 2.5 2 0 0 2 2 2 0 PAN-like domain NAD_binding_10 PF13460.1 KOO34805.1 - 3.4e-11 43.5 0.0 5.1e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 KOO34805.1 - 2e-09 37.2 0.0 1.2e-08 34.6 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 KOO34805.1 - 2.2e-07 30.3 0.0 3.4e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.20 KOO34805.1 - 0.039 13.8 0.1 0.12 12.2 0.0 1.8 2 0 0 2 2 2 0 short chain dehydrogenase TPT PF03151.11 KOO34806.1 - 2.4e-18 66.2 3.9 2.4e-18 66.2 2.7 2.2 2 0 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 KOO34806.1 - 0.0093 15.9 19.4 0.2 11.7 4.7 2.6 2 1 0 2 2 2 2 EamA-like transporter family WD40 PF00400.27 KOO34807.1 - 1.6e-41 138.6 8.3 4.2e-13 48.6 0.3 3.1 3 0 0 3 3 3 3 WD domain, G-beta repeat PD40 PF07676.7 KOO34807.1 - 2.9e-09 36.3 0.0 0.1 12.3 0.0 3.4 3 0 0 3 3 3 3 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOO34807.1 - 7e-06 25.8 0.0 1.1e-05 25.2 0.0 1.3 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.1 KOO34807.1 - 0.00075 19.2 0.0 0.0043 16.8 0.0 2.0 1 1 1 2 2 2 1 Ciliary BBSome complex subunit 2, middle region Nbas_N PF15492.1 KOO34807.1 - 0.0012 18.0 0.6 2.2 7.2 0.0 2.9 1 1 2 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.11 KOO34807.1 - 0.0022 16.3 0.4 0.098 10.9 0.1 2.0 1 1 1 2 2 2 2 Cytochrome D1 heme domain DUF3312 PF11768.3 KOO34807.1 - 0.0026 16.0 0.0 0.099 10.8 0.0 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF3312) Gmad1 PF10647.4 KOO34807.1 - 0.0045 16.4 0.2 1.9 7.8 0.0 2.8 1 1 1 3 3 3 1 Lipoprotein LpqB beta-propeller domain DUF3892 PF13031.1 KOO34807.1 - 0.0056 17.0 0.2 0.59 10.5 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3892) Nup160 PF11715.3 KOO34807.1 - 0.019 13.1 1.1 0.078 11.0 0.7 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 DUF3694 PF12473.3 KOO34807.1 - 0.028 14.0 1.1 0.16 11.6 0.1 2.2 1 1 1 2 2 2 0 Kinesin protein Nucleoporin_N PF08801.6 KOO34807.1 - 0.059 12.1 1.6 0.32 9.6 1.1 2.2 1 1 0 1 1 1 0 Nup133 N terminal like rOmpB PF12334.3 KOO34807.1 - 0.098 12.0 0.4 42 3.4 0.0 2.9 1 1 1 3 3 3 0 Rickettsia outer membrane protein B Proteasome_A_N PF10584.4 KOO34807.1 - 0.26 10.6 2.9 64 2.9 0.1 3.4 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature DUF2529 PF10740.4 KOO34808.1 - 0.097 12.0 0.1 0.16 11.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2529) HIG_1_N PF04588.8 KOO34808.1 - 7.4 6.4 7.5 0.27 11.0 0.5 2.1 2 1 0 2 2 2 0 Hypoxia induced protein conserved region Pkinase PF00069.20 KOO34809.1 - 4.3e-16 58.8 0.0 5.5e-16 58.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34809.1 - 0.025 13.6 0.0 0.044 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase PPR_2 PF13041.1 KOO34810.1 - 2.7e-26 91.2 0.0 3.5e-11 42.8 0.0 4.1 2 1 2 4 4 4 4 PPR repeat family PPR_3 PF13812.1 KOO34810.1 - 1.2e-25 87.5 5.3 7.3e-07 28.9 0.0 5.6 5 0 0 5 5 5 4 Pentatricopeptide repeat domain PPR PF01535.15 KOO34810.1 - 3.2e-25 86.3 0.0 4.4e-06 26.2 0.0 4.5 4 0 0 4 4 4 4 PPR repeat PPR_1 PF12854.2 KOO34810.1 - 5.3e-15 54.5 0.0 3.9e-05 23.0 0.0 4.1 4 0 0 4 4 4 3 PPR repeat BTAD PF03704.12 KOO34810.1 - 0.011 16.0 3.9 0.29 11.4 0.6 2.9 2 1 0 2 2 2 0 Bacterial transcriptional activator domain Apc3 PF12895.2 KOO34810.1 - 0.012 15.6 0.0 2.5 8.2 0.0 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 KOO34810.1 - 0.021 14.5 3.9 12 5.9 0.0 4.2 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO34810.1 - 0.067 13.1 4.6 3.3 7.7 0.1 3.6 3 2 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.1 KOO34810.1 - 0.074 13.0 3.0 3 7.9 0.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 KOO34810.1 - 0.098 13.3 0.1 0.78 10.4 0.0 4.6 2 2 3 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO34810.1 - 0.88 10.3 21.5 2.1 9.1 0.1 5.7 4 1 3 7 7 7 0 Tetratricopeptide repeat adh_short PF00106.20 KOO34811.1 - 4.6e-14 52.6 0.3 1.7e-11 44.3 0.0 2.4 2 1 0 2 2 2 2 short chain dehydrogenase KR PF08659.5 KOO34811.1 - 2.4e-08 33.8 0.0 4.4e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 KOO34811.1 - 0.00031 20.6 0.0 0.018 14.8 0.0 2.4 2 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 KOO34811.1 - 0.0018 17.7 0.2 0.024 14.0 0.1 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 KOO34811.1 - 0.0028 16.6 0.0 0.0042 16.0 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Glyco_tranf_2_3 PF13641.1 KOO34811.1 - 0.013 15.3 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Glyco_tran_WecB PF03808.8 KOO34811.1 - 0.046 13.1 0.0 0.67 9.3 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family NAD_binding_10 PF13460.1 KOO34811.1 - 0.15 12.0 0.8 1.6 8.7 0.6 2.3 1 1 0 1 1 1 0 NADH(P)-binding Fringe PF02434.11 KOO34812.1 - 6.7e-23 81.1 0.0 1.1e-22 80.5 0.0 1.2 1 0 0 1 1 1 1 Fringe-like DUF604 PF04646.7 KOO34812.1 - 2.4e-08 33.5 0.0 3.8e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF604 Glyco_transf_34 PF05637.7 KOO34812.1 - 0.059 12.8 0.0 0.094 12.2 0.0 1.2 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family Galactosyl_T PF01762.16 KOO34812.1 - 0.14 11.7 0.0 1.8 8.1 0.0 2.2 1 1 0 1 1 1 0 Galactosyltransferase 2OG-FeII_Oxy_3 PF13640.1 KOO34813.1 - 0.0058 17.1 0.1 0.016 15.7 0.1 1.8 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ParBc PF02195.13 KOO34813.1 - 0.047 13.8 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 ParB-like nuclease domain 2OG-FeII_Oxy_4 PF13661.1 KOO34813.1 - 0.1 12.2 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily IQ PF00612.22 KOO34814.1 - 4.6 7.1 22.5 0.95 9.2 3.1 3.8 3 0 0 3 3 3 0 IQ calmodulin-binding motif FokI_C PF02980.11 KOO34815.1 - 0.084 12.5 0.0 0.22 11.1 0.0 1.7 1 0 0 1 1 1 0 Restriction endonuclease FokI, catalytic domain MMS19_N PF14500.1 KOO34815.1 - 0.13 11.5 0.0 0.24 10.6 0.0 1.4 1 0 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II Kringle PF00051.13 KOO34816.1 - 8.1e-40 134.7 13.4 1.7e-22 79.3 1.5 2.8 2 0 0 2 2 2 2 Kringle domain Notch PF00066.12 KOO34816.1 - 2.3e-28 98.1 88.7 6.7e-08 32.6 7.4 5.7 5 0 0 5 5 5 5 LNR domain Alpha_kinase PF02816.13 KOO34819.1 - 5.6e-15 55.4 0.0 1.2e-14 54.4 0.0 1.5 1 1 0 1 1 1 1 Alpha-kinase family Rad51 PF08423.6 KOO34819.1 - 0.0011 17.8 0.0 0.0019 17.1 0.0 1.2 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 KOO34819.1 - 0.013 14.9 0.3 0.028 13.8 0.2 1.6 1 1 0 1 1 1 0 AAA domain ICAT PF06384.6 KOO34820.1 - 7.6e-16 57.6 0.1 7.6e-16 57.6 0.1 2.2 2 0 0 2 2 2 1 Beta-catenin-interacting protein ICAT GvpG PF05120.7 KOO34820.1 - 0.00037 20.2 6.8 0.0084 15.8 0.0 2.5 2 0 0 2 2 2 1 Gas vesicle protein G Methyltransf_18 PF12847.2 KOO34820.1 - 0.023 15.2 0.1 0.076 13.6 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain T2SF PF00482.18 KOO34820.1 - 0.034 14.0 4.1 0.33 10.8 0.3 3.1 3 1 0 3 3 3 0 Type II secretion system (T2SS), protein F IncA PF04156.9 KOO34820.1 - 0.039 13.5 4.0 0.066 12.8 2.8 1.4 1 0 0 1 1 1 0 IncA protein DMAP_binding PF06464.6 KOO34820.1 - 0.062 13.8 1.3 6.2 7.4 0.0 2.3 2 0 0 2 2 2 0 DMAP1-binding Domain MTS PF05175.9 KOO34820.1 - 0.079 12.3 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain DUF3313 PF11769.3 KOO34820.1 - 0.081 12.2 1.2 0.15 11.3 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3313) Cas_GSU0054 PF09609.5 KOO34820.1 - 0.082 11.7 0.0 0.1 11.3 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein, GSU0054 family (Cas_GSU0054) FlxA PF14282.1 KOO34820.1 - 0.17 11.8 1.6 0.28 11.1 1.1 1.3 1 0 0 1 1 1 0 FlxA-like protein DUF883 PF05957.8 KOO34820.1 - 0.6 10.5 8.6 0.33 11.3 3.1 2.4 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Arm PF00514.18 KOO34821.1 - 3.2e-23 80.6 18.9 4.3e-05 23.1 0.0 9.3 9 0 0 9 9 9 7 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO34821.1 - 2.2e-06 27.8 24.0 0.00072 19.7 0.2 5.9 4 1 1 6 6 6 3 HEAT repeats HEAT PF02985.17 KOO34821.1 - 0.15 12.2 15.3 1.3 9.2 0.0 5.6 6 0 0 6 6 6 0 HEAT repeat Methyltransf_11 PF08241.7 KOO34822.1 - 6.8e-08 32.9 0.0 1.1e-07 32.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO34822.1 - 1.3e-05 24.9 0.0 1.5e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.11 KOO34822.1 - 2.2e-05 23.0 0.0 2.5e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_31 PF13847.1 KOO34822.1 - 0.00032 20.3 0.0 0.00037 20.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO34822.1 - 0.017 15.5 0.0 0.025 15.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.13 KOO34822.1 - 0.032 13.3 0.0 0.048 12.7 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Pox_MCEL PF03291.11 KOO34822.1 - 0.11 11.3 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 mRNA capping enzyme Sulfotransfer_3 PF13469.1 KOO34823.1 - 4e-06 27.8 4.2 4e-06 27.8 2.9 1.7 2 0 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.22 KOO34823.1 - 0.075 12.2 0.2 0.24 10.6 0.1 1.9 1 1 0 1 1 1 0 Sulfotransferase domain Mito_fiss_reg PF05308.6 KOO34823.1 - 0.56 9.5 5.4 1.4 8.2 3.8 1.6 1 0 0 1 1 1 0 Mitochondrial fission regulator EF-hand_7 PF13499.1 KOO34824.1 - 1.2e-26 92.5 0.1 1.7e-09 37.6 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO34824.1 - 2.2e-22 76.5 4.4 4.8e-07 28.6 0.1 6.6 6 0 0 6 6 6 4 EF hand EF-hand_6 PF13405.1 KOO34824.1 - 2.3e-19 67.4 5.8 0.0001 21.8 0.1 6.5 6 0 0 6 6 6 5 EF-hand domain EF-hand_8 PF13833.1 KOO34824.1 - 5.1e-18 64.4 2.1 6.7e-08 32.0 0.0 5.5 5 1 1 6 6 6 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO34824.1 - 5e-09 35.0 5.0 0.0038 16.5 0.1 5.5 5 0 0 5 5 5 2 EF hand EF-hand_9 PF14658.1 KOO34824.1 - 5.3e-05 23.0 0.0 0.01 15.7 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain TerB PF05099.8 KOO34824.1 - 0.0096 15.6 0.0 0.66 9.7 0.0 2.4 2 0 0 2 2 2 1 Tellurite resistance protein TerB EF-hand_4 PF12763.2 KOO34824.1 - 0.018 14.7 0.0 4 7.2 0.0 2.5 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO34824.1 - 0.13 12.3 0.4 5.8 6.9 0.0 3.2 3 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Leukocidin PF07968.7 KOO34825.1 - 0.014 15.0 4.1 2 8.0 0.1 2.9 3 0 0 3 3 3 0 Leukocidin/Hemolysin toxin family Imm1 PF14430.1 KOO34825.1 - 0.034 14.3 1.3 7.5 6.7 0.0 3.3 3 0 0 3 3 3 0 Immunity protein Imm1 NRPS PF08415.5 KOO34825.1 - 0.12 12.1 2.1 2.9 7.7 0.1 2.9 2 0 0 2 2 2 0 Nonribosomal peptide synthase Gln-synt_C PF00120.19 KOO34825.1 - 0.2 10.7 0.0 16 4.4 0.0 2.2 2 0 0 2 2 2 0 Glutamine synthetase, catalytic domain cNMP_binding PF00027.24 KOO34827.1 - 1.8e-32 110.9 0.2 7.2e-17 60.9 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Arm PF00514.18 KOO34827.1 - 3e-14 52.2 18.4 0.0053 16.5 0.1 8.1 8 0 0 8 8 8 5 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 KOO34827.1 - 0.0015 17.6 0.1 2.9 6.9 0.0 3.6 2 1 2 4 4 4 2 Armadillo-like DRIM PF07539.7 KOO34827.1 - 0.03 13.7 0.3 3.9 6.8 0.0 3.2 3 0 0 3 3 3 0 Down-regulated in metastasis HEAT PF02985.17 KOO34827.1 - 0.033 14.2 4.9 31 5.0 0.0 5.4 4 0 0 4 4 4 0 HEAT repeat DEAD PF00270.24 KOO34828.1 - 6.1e-35 120.1 0.0 8.9e-35 119.6 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO34828.1 - 7.4e-18 64.1 0.0 1.8e-17 62.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO34828.1 - 0.012 15.4 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit SecA_DEAD PF07517.9 KOO34828.1 - 0.014 14.7 0.0 3 7.0 0.0 2.2 2 0 0 2 2 2 0 SecA DEAD-like domain SNF2_N PF00176.18 KOO34828.1 - 0.042 12.6 0.0 0.064 12.0 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain CMS1 PF14617.1 KOO34828.1 - 0.11 11.4 0.1 0.2 10.6 0.1 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit ELFV_dehydrog PF00208.16 KOO34829.1 - 2.4e-26 92.8 0.0 3.7e-26 92.1 0.0 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.7 KOO34829.1 - 1.8e-14 52.2 0.0 1.6e-09 35.8 0.0 3.9 5 0 0 5 5 5 3 Bacterial NAD-glutamate dehydrogenase DUF59 PF01883.14 KOO34830.1 - 7.8e-13 48.2 0.2 1.4e-12 47.3 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function DUF59 RNA_pol_Rpb2_6 PF00562.23 KOO34831.1 - 3.2e-120 401.4 0.0 3.8e-120 401.1 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_4 PF04566.8 KOO34831.1 - 9.6e-15 54.1 1.2 1.5e-14 53.5 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_7 PF04560.15 KOO34831.1 - 1.2e-14 54.2 0.2 2.8e-14 53.1 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_5 PF04567.12 KOO34831.1 - 2.4e-14 53.0 0.1 4.7e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Myb_DNA-binding PF00249.26 KOO34832.1 - 5.2e-05 23.2 0.2 0.0048 16.9 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_5 PF13873.1 KOO34832.1 - 0.034 14.0 0.3 0.31 10.9 0.2 2.2 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Pentapeptide_4 PF13599.1 KOO34833.1 - 9.5e-77 252.8 0.0 1.1e-07 31.5 0.0 14.2 2 2 13 16 16 16 16 Pentapeptide repeats (9 copies) XK-related PF09815.4 KOO34833.1 - 0.00046 19.2 3.7 0.00073 18.6 2.5 1.2 1 0 0 1 1 1 1 XK-related protein Ribosomal_L13e PF01294.13 KOO34833.1 - 0.36 10.2 28.7 9.3 5.6 0.0 12.5 9 6 8 18 18 18 0 Ribosomal protein L13e DUF4110 PF13422.1 KOO34833.1 - 0.65 9.8 2.7 24 4.8 0.0 4.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4110) DUF3110 PF11360.3 KOO34834.1 - 1.6e-18 66.2 0.0 2.3e-18 65.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3110) Herpes_gE PF02480.11 KOO34834.1 - 0.03 12.6 0.0 0.034 12.4 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF1244 PF06844.6 KOO34835.1 - 6.1e-29 99.6 0.1 1.1e-28 98.8 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1244) MoCF_biosynth PF00994.19 KOO34835.1 - 1.3e-23 83.0 0.0 1.1e-21 76.6 0.0 2.5 2 1 0 2 2 2 1 Probable molybdopterin binding domain ASF1_hist_chap PF04729.8 KOO34836.1 - 3.4e-64 215.1 0.1 3.7e-64 215.0 0.0 1.0 1 0 0 1 1 1 1 ASF1 like histone chaperone Ank_2 PF12796.2 KOO34837.1 - 3e-131 428.1 63.1 2.5e-17 62.9 0.3 11.2 4 3 8 12 12 12 12 Ankyrin repeats (3 copies) Ank PF00023.25 KOO34837.1 - 2.1e-108 349.1 87.6 5e-07 29.2 0.1 22.3 22 0 0 22 22 22 22 Ankyrin repeat Ank_5 PF13857.1 KOO34837.1 - 6.7e-83 270.8 50.1 2.6e-09 37.0 0.1 16.4 7 5 8 17 17 17 15 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO34837.1 - 2.2e-78 257.3 25.8 6.9e-09 35.9 0.0 15.7 6 3 10 17 17 17 15 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO34837.1 - 3.5e-69 221.7 33.1 0.0018 18.3 0.0 21.7 22 0 0 22 22 22 19 Ankyrin repeat Shigella_OspC PF06128.6 KOO34837.1 - 0.19 11.1 0.4 1 8.7 0.0 2.5 2 1 0 2 2 2 0 Shigella flexneri OspC protein HEAT PF02985.17 KOO34838.1 - 1.2e-09 37.4 9.3 0.0045 16.9 0.0 5.0 5 0 0 5 5 5 3 HEAT repeat HEAT_2 PF13646.1 KOO34838.1 - 1.6e-05 25.1 8.7 0.0011 19.2 1.3 3.4 3 1 0 3 3 3 2 HEAT repeats Cnd1 PF12717.2 KOO34838.1 - 0.0021 17.9 0.0 0.15 11.8 0.0 2.6 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.1 KOO34838.1 - 0.015 15.8 16.2 2.4 8.7 0.0 4.7 5 0 0 5 5 5 0 HEAT-like repeat DUF2435 PF10363.4 KOO34838.1 - 0.12 12.2 0.4 11 5.9 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2435) Adaptin_N PF01602.15 KOO34838.1 - 0.15 10.3 0.0 1.4 7.1 0.0 1.9 1 1 1 2 2 2 0 Adaptin N terminal region Cohesin_HEAT PF12765.2 KOO34838.1 - 0.28 11.1 13.5 1.6 8.7 0.0 4.7 5 0 0 5 5 5 0 HEAT repeat associated with sister chromatid cohesion Arm PF00514.18 KOO34838.1 - 1.6 8.6 8.7 11 5.9 0.0 4.2 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat zf-C3HC4_2 PF13923.1 KOO34840.1 - 8.5e-07 28.8 3.6 8.5e-07 28.8 2.5 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-CXXC PF02008.15 KOO34840.1 - 1.9e-06 27.5 2.4 1.9e-06 27.5 1.6 2.4 2 1 0 2 2 2 1 CXXC zinc finger domain zf-C3HC4 PF00097.20 KOO34840.1 - 3e-06 26.7 2.8 3e-06 26.7 1.9 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO34840.1 - 1.7e-05 24.5 3.9 1.7e-05 24.5 2.7 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 KOO34840.1 - 0.0003 20.4 2.3 0.0003 20.4 1.6 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.2 KOO34840.1 - 0.0014 18.6 0.6 0.0035 17.4 0.4 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 KOO34840.1 - 0.0017 17.9 4.8 0.0017 17.9 3.3 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 KOO34840.1 - 0.021 14.5 2.2 0.068 12.9 1.5 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_4 PF14570.1 KOO34840.1 - 0.062 12.9 4.7 0.14 11.7 3.3 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.1 KOO34840.1 - 0.74 9.7 8.0 0.11 12.3 1.5 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING EF-hand_7 PF13499.1 KOO34841.1 - 3.5e-12 46.2 0.1 8.8e-12 44.9 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO34841.1 - 5e-10 37.9 0.6 1.7e-05 23.7 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO34841.1 - 6.7e-09 34.6 0.3 8.4e-05 21.7 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO34841.1 - 1.2e-07 31.0 0.5 0.00017 21.1 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO34841.1 - 9.7e-05 21.9 0.2 0.00076 19.0 0.1 2.6 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.1 KOO34841.1 - 0.0013 18.6 0.0 0.0035 17.2 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain YqfQ PF14181.1 KOO34842.1 - 4.6 7.2 5.9 8.3 6.4 4.1 1.4 1 0 0 1 1 1 0 YqfQ-like protein CENP-T PF15511.1 KOO34842.1 - 5.3 6.1 23.1 6.4 5.9 16.0 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Kelch_5 PF13854.1 KOO34845.1 - 6.3e-26 89.8 6.3 7.3e-08 32.2 0.2 6.5 6 1 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 KOO34845.1 - 2.9e-20 71.7 17.5 2.5e-07 30.3 0.5 7.0 7 1 0 7 7 7 5 Galactose oxidase, central domain Kelch_3 PF13415.1 KOO34845.1 - 9.4e-20 70.2 18.7 3.7e-07 30.1 0.1 6.5 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.1 KOO34845.1 - 2.2e-13 49.7 5.9 0.0078 16.3 0.1 6.5 5 1 1 6 6 6 4 Kelch motif Kelch_1 PF01344.20 KOO34845.1 - 1.8e-10 40.1 10.0 0.00036 20.0 0.1 6.2 7 1 0 7 7 7 4 Kelch motif Kelch_2 PF07646.10 KOO34845.1 - 2e-08 33.6 3.4 0.0019 17.9 0.0 5.4 5 0 0 5 5 5 2 Kelch motif Aminotran_1_2 PF00155.16 KOO34846.1 - 1e-44 152.9 0.0 1.2e-44 152.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II gag-asp_proteas PF13975.1 KOO34846.1 - 0.049 13.4 0.2 0.56 10.0 0.0 2.5 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Pkinase PF00069.20 KOO34847.1 - 1.5e-44 152.0 0.0 2.1e-44 151.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34847.1 - 1.8e-23 82.9 0.0 2.6e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO34847.1 - 0.00023 20.9 1.7 0.00031 20.5 0.0 2.0 2 1 1 3 3 3 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 KOO34847.1 - 0.0056 16.0 0.1 0.1 11.9 0.0 2.2 2 1 0 2 2 2 1 PhoP regulatory network protein YrbL Kdo PF06293.9 KOO34847.1 - 0.022 13.8 0.1 0.045 12.8 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 KOO34847.1 - 0.035 13.0 0.0 0.055 12.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like DUF258 PF03193.11 KOO34847.1 - 0.051 12.7 0.1 0.081 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ANF_receptor PF01094.23 KOO34848.1 - 1.7e-14 53.4 0.1 3.7e-10 39.1 0.1 2.3 2 0 0 2 2 2 2 Receptor family ligand binding region Cortex-I_coil PF09304.5 KOO34849.1 - 0.052 13.5 3.2 0.25 11.3 1.2 2.0 2 0 0 2 2 2 0 Cortexillin I, coiled coil Peptidase_S46 PF10459.4 KOO34850.1 - 1.5 7.1 11.9 1.9 6.8 8.3 1.1 1 0 0 1 1 1 0 Peptidase S46 MFS_1 PF07690.11 KOO34851.1 - 5.9e-14 51.5 39.7 6.6e-07 28.3 10.8 2.6 2 1 0 2 2 2 2 Major Facilitator Superfamily Bestrophin PF01062.16 KOO34852.1 - 3.1e-09 36.1 0.5 4.4e-09 35.7 0.3 1.2 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel YtpI PF14007.1 KOO34852.1 - 0.059 13.2 1.2 0.15 12.0 0.8 1.6 1 0 0 1 1 1 0 YtpI-like protein Cpn60_TCP1 PF00118.19 KOO34853.1 - 2.5e-146 488.1 10.8 2.9e-146 487.9 7.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family AAA_19 PF13245.1 KOO34853.1 - 0.009 15.7 0.3 0.12 12.1 0.0 2.5 2 0 0 2 2 2 1 Part of AAA domain Ribosomal_S25 PF03297.10 KOO34853.1 - 0.12 12.3 0.6 0.45 10.5 0.4 1.9 1 0 0 1 1 1 0 S25 ribosomal protein Cupin_4 PF08007.7 KOO34854.1 - 1.1e-07 31.3 0.0 0.00011 21.5 0.0 2.1 2 0 0 2 2 2 2 Cupin superfamily protein Cupin_8 PF13621.1 KOO34854.1 - 2.6e-05 23.8 0.0 3.2e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Peripla_BP_3 PF13377.1 KOO34855.1 - 0.036 14.0 0.0 0.08 12.9 0.0 1.5 1 0 0 1 1 1 0 Periplasmic binding protein-like domain Arm PF00514.18 KOO34858.1 - 2.7e-55 182.4 37.2 2.2e-08 33.6 0.0 10.1 10 0 0 10 10 10 10 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 KOO34858.1 - 6.1e-07 28.7 0.4 0.27 10.3 0.0 5.0 1 1 1 4 4 4 2 Armadillo-like HEAT_2 PF13646.1 KOO34858.1 - 7e-06 26.2 46.3 0.22 11.8 3.4 5.6 2 1 3 6 6 6 6 HEAT repeats RPAP1_C PF08620.5 KOO34858.1 - 2.5e-05 24.0 0.0 69 3.3 0.0 6.8 7 1 0 7 7 7 0 RPAP1-like, C-terminal SBP_bac_8 PF13416.1 KOO34858.1 - 0.00087 19.1 12.0 0.42 10.2 0.6 4.7 2 2 1 4 4 4 2 Bacterial extracellular solute-binding protein Ric8 PF10165.4 KOO34858.1 - 0.0035 16.2 0.1 0.28 9.9 0.0 2.7 2 1 0 2 2 2 1 Guanine nucleotide exchange factor synembryn Atx10homo_assoc PF09759.4 KOO34858.1 - 0.043 13.5 0.1 9.9 5.9 0.0 3.8 2 1 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain HEAT PF02985.17 KOO34858.1 - 0.087 12.9 18.5 6.6 7.1 0.0 7.7 10 0 0 10 10 10 0 HEAT repeat DUF128 PF01995.11 KOO34858.1 - 2 7.3 5.7 12 4.7 0.0 4.5 3 2 4 7 7 7 0 Domain of unknown function DUF128 Pedibin PF08182.6 KOO34859.1 - 0.16 11.4 3.0 0.11 11.9 0.2 2.2 2 0 0 2 2 2 0 Pedibin/Hym-346 family SAP PF02037.22 KOO34860.1 - 0.022 14.2 0.2 0.039 13.4 0.1 1.5 1 1 0 1 1 1 0 SAP domain Paramyxo_PNT PF13825.1 KOO34860.1 - 0.063 12.4 0.3 0.096 11.8 0.2 1.2 1 0 0 1 1 1 0 Paramyxovirus structural protein V/P N-terminus LZ_Tnp_IS66 PF13007.2 KOO34860.1 - 2 9.1 7.1 2.1 9.0 0.5 2.4 2 0 0 2 2 2 0 Transposase C of IS166 homeodomain CSD PF00313.17 KOO34861.1 - 9.2e-27 92.6 0.3 1.1e-26 92.4 0.2 1.1 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.6 KOO34861.1 - 1.2e-05 24.7 0.1 1.9e-05 24.0 0.1 1.4 1 0 0 1 1 1 1 Ribonuclease B OB domain DNA_gyraseA_C PF03989.8 KOO34861.1 - 0.018 14.3 0.1 0.17 11.2 0.0 2.0 2 0 0 2 2 2 0 DNA gyrase C-terminal domain, beta-propeller DIM1 PF02966.11 KOO34862.1 - 4.7e-20 71.4 0.0 6.4e-20 71.0 0.0 1.1 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredox_DsbH PF03190.10 KOO34862.1 - 0.016 14.9 0.0 0.035 13.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.1 KOO34862.1 - 0.028 14.4 0.0 0.06 13.3 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like Glyco_hydro_76 PF03663.9 KOO34863.1 - 5.8e-45 154.2 18.7 6.7e-45 154.0 13.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 DUF1680 PF07944.7 KOO34863.1 - 0.0017 16.6 0.0 0.0074 14.6 0.0 1.8 2 0 0 2 2 2 1 Putative glycosyl hydrolase of unknown function (DUF1680) Mec-17 PF05301.6 KOO34865.1 - 6.4e-32 110.0 0.0 8.9e-32 109.5 0.0 1.2 1 0 0 1 1 1 1 Touch receptor neuron protein Mec-17 Acetyltransf_1 PF00583.19 KOO34865.1 - 0.063 13.3 0.0 2.1 8.4 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family Aa_trans PF01490.13 KOO34866.1 - 5.3e-31 107.5 11.6 4.4e-20 71.5 3.2 2.0 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein F-box-like PF12937.2 KOO34869.1 - 1e-06 28.3 0.1 1e-06 28.3 0.0 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 KOO34869.1 - 0.00073 19.1 0.8 0.0016 18.0 0.0 1.9 2 0 0 2 2 2 1 F-box domain EF-hand_8 PF13833.1 KOO34870.1 - 0.089 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair p450 PF00067.17 KOO34871.1 - 2.9e-43 148.0 0.0 3.9e-43 147.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Lactamase_B PF00753.22 KOO34872.1 - 8.1e-22 77.8 1.1 1.1e-21 77.4 0.8 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 KOO34872.1 - 4.7e-06 26.2 0.0 8.4e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 KOO34872.1 - 0.0028 17.3 0.0 0.0042 16.8 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain FAD_binding_3 PF01494.14 KOO34873.1 - 6e-25 88.0 4.3 3e-24 85.7 3.0 2.0 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 KOO34873.1 - 3.5e-05 22.8 0.3 3.5e-05 22.8 0.2 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 KOO34873.1 - 6.6e-05 22.8 1.0 0.0002 21.3 0.7 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Radical_SAM PF04055.16 KOO34873.1 - 0.00021 21.4 0.0 0.00075 19.7 0.0 1.9 1 1 0 1 1 1 1 Radical SAM superfamily Pyr_redox_2 PF07992.9 KOO34873.1 - 0.018 14.9 0.8 0.034 14.0 0.6 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase M20_dimer PF07687.9 KOO34873.1 - 0.021 14.5 0.0 0.047 13.4 0.0 1.7 1 0 0 1 1 1 0 Peptidase dimerisation domain Pyr_redox PF00070.22 KOO34873.1 - 0.024 15.0 1.3 0.12 12.8 0.8 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOO34873.1 - 0.034 14.2 1.7 1 9.4 1.3 2.5 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 KOO34873.1 - 0.052 12.4 0.2 3.6 6.3 0.3 2.5 2 0 0 2 2 2 0 Lycopene cyclase protein AAA_5 PF07728.9 KOO34874.1 - 1.5e-19 70.1 0.0 1.8e-18 66.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) VWA_2 PF13519.1 KOO34874.1 - 1.6e-13 51.1 0.0 4.1e-13 49.8 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 KOO34874.1 - 1.2e-09 38.0 0.0 2.1e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain AAA_3 PF07726.6 KOO34874.1 - 3.8e-06 26.5 0.0 7.5e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) VWA_3 PF13768.1 KOO34874.1 - 5.1e-06 26.2 0.1 5.8e-05 22.8 0.0 2.6 2 1 0 2 2 2 1 von Willebrand factor type A domain AAA PF00004.24 KOO34874.1 - 0.0002 21.5 0.0 0.00056 20.1 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) VWA_CoxE PF05762.9 KOO34874.1 - 0.0002 20.5 0.1 0.0013 17.8 0.0 2.1 1 1 0 1 1 1 1 VWA domain containing CoxE-like protein AAA_16 PF13191.1 KOO34874.1 - 0.00039 20.4 1.5 0.0018 18.2 0.4 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 KOO34874.1 - 0.00039 20.5 0.0 0.0017 18.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 KOO34874.1 - 0.00045 19.6 0.0 0.001 18.5 0.0 1.5 1 1 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.16 KOO34874.1 - 0.0023 17.1 0.0 0.0068 15.5 0.0 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI RuvB_N PF05496.7 KOO34874.1 - 0.04 12.9 0.0 0.071 12.1 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 KOO34874.1 - 0.045 13.6 0.0 0.71 9.7 0.0 2.9 3 0 0 3 3 3 0 AAA domain vWA-TerF-like PF10138.4 KOO34874.1 - 0.068 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 vWA found in TerF C terminus SET PF00856.23 KOO34875.1 - 7.5e-12 45.8 0.0 3.2e-10 40.5 0.0 2.5 2 1 0 2 2 2 1 SET domain Ank_2 PF12796.2 KOO34876.1 - 2.4e-71 236.1 19.6 1.9e-17 63.3 0.0 7.4 4 2 3 7 7 7 7 Ankyrin repeats (3 copies) Ank PF00023.25 KOO34876.1 - 1.8e-57 188.4 23.6 1.8e-05 24.3 0.0 12.7 12 0 0 12 12 12 11 Ankyrin repeat Ank_5 PF13857.1 KOO34876.1 - 5.5e-48 159.9 15.1 2.6e-07 30.6 0.0 10.3 6 3 4 10 10 10 10 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO34876.1 - 1.9e-47 158.8 9.6 6.6e-09 36.0 0.0 9.6 6 3 4 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO34876.1 - 4.8e-40 131.5 17.2 0.032 14.4 0.0 12.8 12 0 0 12 12 12 10 Ankyrin repeat ART PF01129.13 KOO34876.1 - 2.1e-07 30.2 0.0 5.8e-07 28.8 0.0 1.8 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase EF-hand_5 PF13202.1 KOO34876.1 - 0.00014 20.9 2.6 0.0054 16.0 0.0 3.8 3 0 0 3 3 3 1 EF hand ADPrib_exo_Tox PF03496.9 KOO34876.1 - 0.00025 20.2 0.0 0.00081 18.6 0.0 1.8 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme EF-hand_1 PF00036.27 KOO34876.1 - 0.0012 18.0 0.5 0.13 11.6 0.0 3.8 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.1 KOO34876.1 - 0.0071 16.4 0.2 0.12 12.5 0.0 3.0 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO34876.1 - 0.0075 16.0 0.1 0.3 11.0 0.0 3.6 3 0 0 3 3 3 1 EF-hand domain DUF3881 PF12997.2 KOO34876.1 - 0.18 10.8 1.1 3.4 6.5 0.1 2.8 2 1 0 3 3 3 0 Domain of unknown function, E. rectale Gene description (DUF3881) Y_phosphatase2 PF03162.8 KOO34877.1 - 8.6e-57 191.0 0.0 9.8e-57 190.9 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 KOO34877.1 - 1.4e-09 38.4 0.0 1.1e-07 32.2 0.0 2.0 1 1 1 2 2 2 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 KOO34877.1 - 0.00051 19.4 0.0 0.00063 19.1 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.15 KOO34877.1 - 0.0015 18.0 0.2 0.0016 18.0 0.2 1.3 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Zip PF02535.17 KOO34878.1 - 4.3e-12 45.6 7.7 9.5e-12 44.5 5.3 1.6 1 1 0 1 1 1 1 ZIP Zinc transporter UCH PF00443.24 KOO34879.1 - 7.8e-29 100.6 0.5 1.1e-13 50.9 0.0 3.1 1 1 2 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOO34879.1 - 5.3e-08 32.6 0.0 0.00066 19.2 0.0 2.4 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.18 KOO34879.1 - 0.00028 20.2 0.0 0.019 14.3 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin family Imm42 PF15601.1 KOO34879.1 - 0.092 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 42 Pan_kinase PF03309.9 KOO34880.1 - 0.016 14.7 0.2 2.1 7.8 0.0 2.7 2 0 0 2 2 2 0 Type III pantothenate kinase FliT PF05400.8 KOO34880.1 - 0.037 14.4 12.9 2.1 8.8 0.0 5.5 6 0 0 6 6 6 0 Flagellar protein FliT DNA_repr_REX1B PF14966.1 KOO34880.1 - 0.087 13.2 0.0 3.5 8.0 0.0 3.3 3 0 0 3 3 3 0 DNA repair REX1-B DUF1926 PF09095.6 KOO34880.1 - 0.096 11.8 0.0 11 5.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1926) Bestrophin PF01062.16 KOO34881.1 - 2.7e-26 92.1 2.0 3.2e-26 91.9 1.4 1.0 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Oxidored_q2 PF00420.19 KOO34881.1 - 0.63 9.6 7.9 0.19 11.3 2.7 2.1 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L TIP49 PF06068.8 KOO34882.1 - 2.2e-183 609.4 6.0 2.9e-183 609.0 4.2 1.1 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.24 KOO34882.1 - 1.9e-08 34.5 2.7 1.1e-05 25.5 0.2 3.2 2 2 1 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOO34882.1 - 6.2e-07 29.6 2.1 0.049 13.7 0.5 3.0 1 1 0 2 2 2 2 AAA domain DnaB_C PF03796.10 KOO34882.1 - 1.6e-06 27.1 0.2 2.6e-06 26.5 0.1 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.1 KOO34882.1 - 3.3e-06 27.2 0.1 2.8e-05 24.1 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.7 KOO34882.1 - 5.2e-06 25.6 2.3 0.0012 17.9 0.1 2.9 4 0 0 4 4 4 2 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 KOO34882.1 - 8.7e-06 25.5 0.5 0.0028 17.3 0.0 2.9 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 KOO34882.1 - 1.3e-05 24.7 0.1 2.5e-05 23.7 0.1 1.6 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.21 KOO34882.1 - 0.00016 21.2 0.1 0.19 11.1 0.1 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain Mg_chelatase PF01078.16 KOO34882.1 - 0.00037 19.7 1.2 0.0083 15.3 0.3 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 KOO34882.1 - 0.00058 19.0 0.3 0.0015 17.6 0.2 1.6 1 0 0 1 1 1 1 Zeta toxin KaiC PF06745.8 KOO34882.1 - 0.00098 18.2 0.6 0.0017 17.4 0.4 1.4 1 0 0 1 1 1 1 KaiC AAA_19 PF13245.1 KOO34882.1 - 0.0023 17.6 0.4 0.0078 15.9 0.1 2.1 2 0 0 2 2 1 1 Part of AAA domain DUF2075 PF09848.4 KOO34882.1 - 0.0045 16.0 0.1 0.0068 15.4 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) NACHT PF05729.7 KOO34882.1 - 0.0067 16.1 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_14 PF13173.1 KOO34882.1 - 0.0075 16.1 0.1 8.5 6.2 0.0 3.1 3 0 0 3 3 3 0 AAA domain Zot PF05707.7 KOO34882.1 - 0.011 15.2 0.4 0.36 10.2 0.0 2.6 3 0 0 3 3 2 0 Zonular occludens toxin (Zot) AAA_23 PF13476.1 KOO34882.1 - 0.013 15.8 0.1 0.025 14.9 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 KOO34882.1 - 0.013 15.8 0.5 0.035 14.3 0.1 2.0 2 0 0 2 2 2 0 AAA domain UPF0079 PF02367.12 KOO34882.1 - 0.027 14.0 0.1 0.068 12.7 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 FtsK_SpoIIIE PF01580.13 KOO34882.1 - 0.033 13.6 0.8 0.29 10.5 0.1 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family IstB_IS21 PF01695.12 KOO34882.1 - 0.036 13.4 0.1 0.077 12.4 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_17 PF13207.1 KOO34882.1 - 0.039 14.7 0.2 0.12 13.2 0.0 2.0 2 0 0 2 2 1 0 AAA domain Imm41 PF15583.1 KOO34882.1 - 0.059 13.1 0.4 0.12 12.1 0.3 1.5 1 0 0 1 1 1 0 Immunity protein 41 AAA_11 PF13086.1 KOO34882.1 - 0.063 12.8 0.0 0.092 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 KOO34882.1 - 0.091 12.7 0.3 0.28 11.1 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.1 KOO34882.1 - 0.093 12.6 0.0 0.25 11.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain Sipho_tail PF05709.6 KOO34882.1 - 0.15 11.1 0.0 0.25 10.4 0.0 1.3 1 0 0 1 1 1 0 Phage tail protein AAA_2 PF07724.9 KOO34882.1 - 0.32 10.8 3.8 0.51 10.2 0.7 2.7 1 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) ResIII PF04851.10 KOO34882.1 - 0.45 10.3 2.7 2.4 7.9 1.9 2.0 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Scramblase PF03803.10 KOO34883.1 - 4.7e-27 94.5 0.0 1.6e-26 92.8 0.0 1.7 1 1 0 1 1 1 1 Scramblase S-AdoMet_synt_C PF02773.11 KOO34884.1 - 4e-64 214.4 0.1 7.2e-64 213.6 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.11 KOO34884.1 - 4.6e-35 120.1 0.0 7e-34 116.3 0.0 2.8 2 1 0 2 2 2 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.15 KOO34884.1 - 2.1e-34 117.7 0.3 3.9e-34 116.8 0.2 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain Pkinase PF00069.20 KOO34886.1 - 0.026 13.6 0.0 0.026 13.6 0.0 2.7 2 1 0 2 2 2 0 Protein kinase domain DSBA PF01323.15 KOO34886.1 - 0.33 10.4 11.5 0.8 9.2 7.8 1.7 1 1 0 1 1 1 0 DSBA-like thioredoxin domain DUF4573 PF15140.1 KOO34886.1 - 2.5 7.6 21.9 1.1 8.8 11.0 2.7 1 1 0 2 2 2 0 Domain of unknown function (DUF4573) TPT PF03151.11 KOO34888.1 - 6e-11 42.2 11.0 6e-11 42.2 7.6 1.8 2 1 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 KOO34888.1 - 1.3e-10 40.7 13.2 1.8e-10 40.2 9.2 1.1 1 0 0 1 1 1 1 UAA transporter family adh_short PF00106.20 KOO34888.1 - 0.0044 16.9 3.8 0.013 15.3 0.3 2.4 1 1 1 2 2 2 1 short chain dehydrogenase EamA PF00892.15 KOO34888.1 - 0.023 14.7 26.7 0.049 13.6 9.2 2.7 2 1 0 2 2 2 0 EamA-like transporter family COX14 PF14880.1 KOO34888.1 - 0.055 13.0 0.0 0.22 11.2 0.0 2.0 1 0 0 1 1 1 0 Cytochrome oxidase c assembly Conotoxin PF02950.12 KOO34888.1 - 0.2 12.4 0.6 15 6.4 0.0 3.1 3 0 0 3 3 3 0 Conotoxin DUF4017 PF13209.1 KOO34888.1 - 0.63 9.8 6.7 2.6 7.8 0.3 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4017) Nuc_rec_co-act PF08815.5 KOO34890.1 - 0.0046 16.4 0.4 0.0097 15.4 0.3 1.5 1 0 0 1 1 1 1 Nuclear receptor coactivator TraC_F_IV PF11130.3 KOO34890.1 - 0.035 13.5 0.8 1.7 7.9 0.0 2.4 2 1 0 2 2 2 0 F pilus assembly Type-IV secretion system for plasmid transfer TPR_2 PF07719.12 KOO34891.1 - 3.2e-05 23.5 2.9 3.7 7.6 0.1 5.1 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO34891.1 - 0.0015 18.1 11.6 0.018 14.6 0.1 4.8 4 1 0 4 4 4 2 TPR repeat TPR_1 PF00515.23 KOO34891.1 - 0.012 15.1 0.6 52 3.6 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO34891.1 - 0.013 15.4 5.3 1.4 8.8 0.2 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat EF-hand_1 PF00036.27 KOO34892.1 - 3.3e-12 44.7 0.8 1.6e-05 23.8 0.2 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO34892.1 - 7.2e-11 41.0 0.2 0.00011 21.8 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO34892.1 - 1.4e-09 37.9 0.1 2.1e-09 37.3 0.1 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO34892.1 - 4.3e-08 32.6 0.1 2.7e-06 26.9 0.0 2.5 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO34892.1 - 8.5e-08 31.1 0.5 7.5e-05 21.8 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.1 KOO34892.1 - 0.083 12.5 0.1 0.36 10.5 0.0 1.9 1 1 1 2 2 2 0 EF hand MBOAT PF03062.14 KOO34894.1 - 4.6e-34 117.9 11.9 6.3e-34 117.5 8.3 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family ABC_tran PF00005.22 KOO34895.1 - 1.7e-09 38.0 0.4 9.8e-09 35.6 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.1 KOO34895.1 - 0.031 14.2 0.0 0.048 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.1 KOO34895.1 - 0.039 13.8 0.5 0.7 9.8 0.0 2.7 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF3774 PF12609.3 KOO34895.1 - 0.24 12.2 9.1 0.072 13.9 3.1 2.3 2 0 0 2 2 2 0 Wound-induced protein Pro_CA PF00484.14 KOO34896.1 - 1.3e-14 54.4 0.6 7.6e-14 51.9 0.1 2.0 2 0 0 2 2 2 1 Carbonic anhydrase PWWP PF00855.12 KOO34898.1 - 7.8e-11 42.0 0.6 7.8e-11 42.0 0.4 2.4 2 1 0 2 2 2 1 PWWP domain Chromo PF00385.19 KOO34898.1 - 6.5e-10 38.5 0.0 1.4e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DUF3354 PF11834.3 KOO34898.1 - 8.2e-08 31.7 0.0 1.6e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3354) CAF1A PF12253.3 KOO34898.1 - 1.7e-07 31.2 6.0 1.7e-07 31.2 4.2 3.4 3 1 0 3 3 3 1 Chromatin assembly factor 1 subunit A CAF-1_p150 PF11600.3 KOO34898.1 - 0.00084 18.7 36.2 0.00084 18.7 25.1 2.8 3 0 0 3 3 3 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal TEX19 PF15553.1 KOO34898.1 - 0.006 16.4 0.4 0.006 16.4 0.3 3.3 3 0 0 3 3 3 1 Testis-expressed protein 19 LMBR1 PF04791.11 KOO34898.1 - 0.16 10.4 0.0 0.21 10.1 0.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein LRR_6 PF13516.1 KOO34899.1 - 3.2e-10 38.9 0.6 0.053 13.6 0.2 4.7 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.2 KOO34899.1 - 1.5e-05 24.5 0.0 0.0023 17.4 0.1 2.5 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) ODR4-like PF14778.1 KOO34900.1 - 2.2e-31 108.8 0.0 2.7e-31 108.5 0.0 1.0 1 0 0 1 1 1 1 Olfactory receptor 4-like RNA_capsid PF03035.9 KOO34902.1 - 0.023 14.5 2.4 0.027 14.2 1.7 1.1 1 0 0 1 1 1 0 Calicivirus putative RNA polymerase/capsid protein EF-hand_1 PF00036.27 KOO34903.1 - 3.1e-07 29.2 0.1 0.14 11.5 0.0 4.3 5 0 0 5 5 5 2 EF hand EF-hand_6 PF13405.1 KOO34903.1 - 1.1e-06 28.0 2.2 0.037 13.9 0.0 3.5 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.1 KOO34903.1 - 3.3e-06 26.1 0.0 0.059 12.7 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 KOO34903.1 - 1.3e-05 25.2 0.0 0.11 12.7 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO34903.1 - 0.00083 18.9 0.2 1 9.0 0.0 3.6 4 0 0 4 4 4 2 EF-hand domain pair PT PF04886.7 KOO34903.1 - 6.9 6.0 20.9 6.7 6.1 0.4 2.7 2 0 0 2 2 2 0 PT repeat DUF4355 PF14265.1 KOO34905.1 - 3.1 7.7 24.1 3.9 7.4 5.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) UCH PF00443.24 KOO34906.1 - 1.2e-21 77.0 0.0 1.8e-21 76.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase EF-hand_5 PF13202.1 KOO34907.1 - 0.0032 16.7 0.0 0.007 15.6 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KOO34907.1 - 0.022 14.0 0.0 0.043 13.1 0.0 1.5 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.1 KOO34907.1 - 0.035 14.2 0.0 0.12 12.5 0.0 2.0 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.1 KOO34907.1 - 0.12 12.2 0.0 0.32 11.0 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain AAA_34 PF13872.1 KOO34908.1 - 5e-103 344.0 0.0 1.2e-54 185.1 0.0 2.3 2 0 0 2 2 2 2 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.1 KOO34908.1 - 1.4e-93 313.3 1.3 2.4e-93 312.6 0.9 1.4 1 0 0 1 1 1 1 Helicase_C-like Helicase_C PF00271.26 KOO34908.1 - 0.014 15.2 0.0 0.034 14.0 0.0 1.6 1 0 0 1 1 1 0 Helicase conserved C-terminal domain Dimer_Tnp_hAT PF05699.9 KOO34909.1 - 6.1e-10 38.5 0.0 1e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region LRR_5 PF13306.1 KOO34911.1 - 4.3e-100 330.4 0.0 1e-36 125.4 0.0 3.1 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO34911.1 - 5.8e-40 134.8 0.6 2.2e-05 24.1 0.0 7.4 2 1 8 10 10 10 9 Leucine rich repeat Adeno_E1B_55K PF01696.12 KOO34911.1 - 0.037 12.4 0.4 0.077 11.4 0.3 1.5 1 0 0 1 1 1 0 Adenovirus EB1 55K protein / large t-antigen Peptidase_S8 PF00082.17 KOO34912.1 - 9e-25 87.3 2.1 1.8e-24 86.3 1.4 1.5 1 0 0 1 1 1 1 Subtilase family Peptidase_C69 PF03577.10 KOO34912.1 - 8.5e-11 41.3 0.0 1.2e-09 37.5 0.0 2.3 1 1 0 1 1 1 1 Peptidase family C69 P_proprotein PF01483.15 KOO34912.1 - 1.5e-08 34.3 0.1 2.8e-07 30.2 0.0 2.3 2 0 0 2 2 2 1 Proprotein convertase P-domain Pectate_lyase_2 PF06917.7 KOO34912.1 - 0.4 8.8 0.0 0.62 8.2 0.0 1.2 1 0 0 1 1 1 0 Periplasmic pectate lyase Syja_N PF02383.13 KOO34913.1 - 9.4e-51 172.4 0.0 1.4e-49 168.5 0.0 2.0 2 0 0 2 2 2 1 SacI homology domain Exo_endo_phos PF03372.18 KOO34913.1 - 1.2e-10 41.8 0.0 8.6e-10 38.9 0.0 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PAP_fibrillin PF04755.7 KOO34914.1 - 1.2e-08 34.8 0.0 0.00031 20.5 0.0 2.2 2 0 0 2 2 2 2 PAP_fibrillin Sel1 PF08238.7 KOO34915.1 - 0.00042 20.8 0.1 0.0032 18.0 0.0 2.7 2 0 0 2 2 2 1 Sel1 repeat WW PF00397.21 KOO34916.1 - 8.6e-06 25.5 1.5 1.7e-05 24.5 1.0 1.5 1 0 0 1 1 1 1 WW domain DUF1501 PF07394.7 KOO34918.1 - 4.3e-41 141.0 0.0 6.9e-41 140.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1501) DUF1800 PF08811.6 KOO34918.1 - 7.8e-25 87.7 0.0 1.3e-24 86.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1800) AAA_6 PF12774.2 KOO34920.1 - 4.9e-49 166.9 0.2 6.3e-49 166.5 0.1 1.2 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 FPL PF09758.4 KOO34920.1 - 0.04 13.6 0.2 0.08 12.7 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised conserved protein WD40 PF00400.27 KOO34921.1 - 7.1e-08 32.0 4.6 0.001 18.8 0.3 4.8 4 0 0 4 4 4 2 WD domain, G-beta repeat PQQ_3 PF13570.1 KOO34921.1 - 0.00032 20.8 0.3 3.3 8.1 0.0 3.9 4 0 0 4 4 4 2 PQQ-like domain PQQ PF01011.16 KOO34921.1 - 0.039 13.4 0.0 4.4 7.0 0.0 2.9 2 0 0 2 2 2 0 PQQ enzyme repeat LRR_6 PF13516.1 KOO34922.1 - 7.3e-18 62.5 12.3 0.049 13.6 0.0 10.4 11 0 0 11 11 11 5 Leucine Rich repeat LRR_8 PF13855.1 KOO34922.1 - 0.00017 21.2 0.7 2.8 7.7 0.0 4.7 3 1 0 4 4 4 2 Leucine rich repeat LRR_4 PF12799.2 KOO34922.1 - 0.00042 19.8 7.7 0.19 11.4 0.1 4.5 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO34922.1 - 0.00046 19.8 1.3 96 3.6 0.2 6.2 6 1 0 6 6 6 0 Leucine Rich Repeat FIBP PF05427.6 KOO34922.1 - 0.0038 16.5 0.1 0.61 9.2 0.0 2.1 2 0 0 2 2 2 2 Acidic fibroblast growth factor binding (FIBP) LRR_7 PF13504.1 KOO34922.1 - 0.0044 16.9 2.4 97 3.8 0.0 5.6 5 0 0 5 5 5 0 Leucine rich repeat Metal_CEHH PF14455.1 KOO34922.1 - 0.069 12.5 0.1 0.68 9.3 0.0 2.4 1 1 2 3 3 3 0 Predicted metal binding domain SpoU_sub_bind PF08032.7 KOO34922.1 - 0.095 12.8 0.1 42 4.4 0.0 3.5 4 0 0 4 4 4 0 RNA 2'-O ribose methyltransferase substrate binding PH PF00169.24 KOO34923.1 - 1.1e-07 31.9 0.0 1.8e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 PH domain Gelsolin PF00626.17 KOO34923.1 - 1.2e-06 28.0 0.0 0.00043 19.9 0.0 2.4 2 0 0 2 2 2 2 Gelsolin repeat PH_11 PF15413.1 KOO34923.1 - 0.023 14.9 0.0 0.042 14.0 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain Lipid_DES PF08557.5 KOO34923.1 - 0.15 11.3 0.8 0.42 9.9 0.6 1.7 1 0 0 1 1 1 0 Sphingolipid Delta4-desaturase (DES) Pkinase PF00069.20 KOO34924.1 - 2.9e-22 79.0 0.0 7.7e-22 77.6 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34924.1 - 1.9e-20 73.0 0.2 1.8e-19 69.8 0.1 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 KOO34924.1 - 0.11 11.8 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 RIO1 family CBM_14 PF01607.19 KOO34925.1 - 0.053 13.4 0.5 0.13 12.1 0.1 1.8 2 0 0 2 2 2 0 Chitin binding Peritrophin-A domain FTCD_C PF04961.7 KOO34925.1 - 0.079 12.3 0.0 0.1 11.9 0.0 1.1 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase SBBP PF06739.6 KOO34927.1 - 1.4e-14 53.5 37.0 0.0013 18.4 1.4 7.1 7 0 0 7 7 7 5 Beta-propeller repeat DUF4102 PF13356.1 KOO34927.1 - 0.00049 19.9 0.1 66 3.4 0.0 5.6 6 0 0 6 6 6 0 Domain of unknown function (DUF4102) ImmE5 PF11480.3 KOO34927.1 - 0.042 13.6 0.0 0.088 12.6 0.0 1.5 1 0 0 1 1 1 0 Colicin-E5 Imm protein NMU PF02070.10 KOO34927.1 - 0.37 10.3 5.8 59 3.3 0.1 4.5 4 0 0 4 4 4 0 Neuromedin U DUF2807 PF10988.3 KOO34927.1 - 0.39 10.2 2.6 3.9 6.9 0.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2807) Glyco_hydro_42M PF08532.5 KOO34927.1 - 7.3 5.6 6.3 51 2.9 0.1 3.3 3 0 0 3 3 3 0 Beta-galactosidase trimerisation domain PHO4 PF01384.15 KOO34928.1 - 1e-100 336.5 11.0 1.4e-100 336.1 7.7 1.1 1 0 0 1 1 1 1 Phosphate transporter family MRP-S26 PF14943.1 KOO34929.1 - 0.2 11.1 6.8 0.42 10.1 4.7 1.4 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Atg14 PF10186.4 KOO34929.1 - 2.3 7.0 11.9 3.5 6.4 8.2 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Pkinase PF00069.20 KOO34930.1 - 2.9e-45 154.4 0.0 3.7e-45 154.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34930.1 - 9.5e-21 74.0 0.0 2.2e-20 72.8 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO34930.1 - 0.00026 20.1 0.0 0.00043 19.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO34930.1 - 0.0099 15.6 0.2 0.0099 15.6 0.1 2.6 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO34930.1 - 0.033 13.1 0.0 0.054 12.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Sigma70_r3 PF04539.11 KOO34930.1 - 0.096 12.5 0.3 0.24 11.3 0.2 1.6 1 0 0 1 1 1 0 Sigma-70 region 3 DnaB_bind PF10410.4 KOO34930.1 - 0.36 10.8 2.6 7.2 6.6 0.5 2.5 2 0 0 2 2 2 0 DnaB-helicase binding domain of primase SPX PF03105.14 KOO34932.1 - 2.9e-19 69.9 0.4 1.6e-09 37.9 0.1 3.3 2 1 0 2 2 2 2 SPX domain CENP-S PF15630.1 KOO34932.1 - 0.03 14.5 0.0 0.055 13.6 0.0 1.3 1 0 0 1 1 1 0 Kinetochore component CENP-S Chloroa_b-bind PF00504.16 KOO34933.1 - 2.2e-32 112.5 0.1 4e-32 111.6 0.0 1.5 2 0 0 2 2 2 1 Chlorophyll A-B binding protein TBCC PF07986.7 KOO34934.1 - 4.7e-20 71.1 3.4 6.6e-20 70.7 2.3 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor C LRR_6 PF13516.1 KOO34935.1 - 1.9e-17 61.3 22.2 0.38 10.9 0.0 15.7 17 0 0 17 17 17 3 Leucine Rich repeat LRR_1 PF00560.28 KOO34935.1 - 6.4e-10 37.6 11.3 1.9 8.8 0.0 10.8 12 0 0 12 12 12 2 Leucine Rich Repeat LRR_4 PF12799.2 KOO34935.1 - 0.0041 16.6 13.4 9.5 5.9 0.2 7.5 9 0 0 9 9 9 2 Leucine Rich repeats (2 copies) CBM_5_12 PF02839.9 KOO34935.1 - 0.014 14.9 1.4 7.1 6.3 0.1 3.0 3 0 0 3 3 3 0 Carbohydrate binding domain LRR_8 PF13855.1 KOO34935.1 - 0.018 14.8 4.9 49 3.7 0.0 6.6 7 0 0 7 7 7 0 Leucine rich repeat Skp1 PF01466.14 KOO34935.1 - 0.045 13.7 0.0 0.17 11.9 0.0 1.9 2 0 0 2 2 2 0 Skp1 family, dimerisation domain SPRY PF00622.23 KOO34935.1 - 0.17 12.0 0.0 0.39 10.8 0.0 1.6 1 0 0 1 1 1 0 SPRY domain LRR_7 PF13504.1 KOO34935.1 - 0.65 10.4 15.4 35 5.2 0.6 7.9 7 0 0 7 7 7 0 Leucine rich repeat Gag_p30 PF02093.11 KOO34937.1 - 0.074 12.2 0.4 0.18 11.0 0.1 1.7 2 0 0 2 2 2 0 Gag P30 core shell protein DIE2_ALG10 PF04922.7 KOO34938.1 - 1e-54 186.0 0.2 1.4e-54 185.5 0.1 1.2 1 0 0 1 1 1 1 DIE2/ALG10 family DUF563 PF04577.9 KOO34939.1 - 7.5e-20 71.7 0.0 9.6e-20 71.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Hydrolase PF00702.21 KOO34940.1 - 2.1e-06 28.3 0.0 3.4e-06 27.6 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO34940.1 - 8.4e-05 22.8 0.0 9.3e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOO34940.1 - 0.00036 20.4 0.0 0.00075 19.4 0.0 1.5 1 1 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Ocular_alb PF02101.10 KOO34940.1 - 0.093 11.3 0.0 0.14 10.7 0.0 1.2 1 0 0 1 1 1 0 Ocular albinism type 1 protein E1-E2_ATPase PF00122.15 KOO34941.1 - 3.1e-18 65.6 0.0 1.1e-14 54.0 0.0 2.6 2 1 0 2 2 2 2 E1-E2 ATPase Cation_ATPase_N PF00690.21 KOO34941.1 - 2.7e-05 23.5 0.0 8.1e-05 22.0 0.0 1.8 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus HAD PF12710.2 KOO34941.1 - 0.016 15.3 0.3 0.034 14.3 0.2 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase TPR_11 PF13414.1 KOO34942.1 - 5.4e-20 70.7 11.9 1.3e-07 31.2 0.3 4.0 3 1 1 4 4 4 4 TPR repeat TPR_1 PF00515.23 KOO34942.1 - 2e-17 61.9 9.4 4.9e-06 25.9 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO34942.1 - 2.7e-15 55.1 3.9 1.9e-05 24.4 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO34942.1 - 2.7e-11 42.4 5.4 0.0088 15.7 0.0 5.0 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO34942.1 - 5.3e-11 42.8 14.7 2.7e-06 27.8 3.7 4.2 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_12 PF13424.1 KOO34942.1 - 4.9e-10 39.2 7.9 0.0006 19.7 0.2 3.8 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO34942.1 - 1.1e-09 37.3 16.7 0.00013 21.6 0.1 5.2 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO34942.1 - 2.3e-07 30.8 14.1 0.016 15.7 0.2 5.7 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO34942.1 - 2.3e-06 26.9 7.9 0.0043 16.7 0.2 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO34942.1 - 4.7e-06 26.8 6.5 0.004 17.4 2.2 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.1 KOO34942.1 - 2.2e-05 24.2 10.7 0.0088 15.9 0.2 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_20 PF14561.1 KOO34942.1 - 0.00086 19.3 3.3 0.031 14.3 0.2 2.8 2 1 1 3 3 2 2 Tetratricopeptide repeat 2OG-FeII_Oxy PF03171.15 KOO34942.1 - 0.0029 17.8 0.0 0.0056 16.9 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TPR_3 PF07720.7 KOO34942.1 - 0.0043 16.8 0.1 1.5 8.6 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.1 KOO34942.1 - 0.022 15.1 4.5 0.26 11.8 0.2 3.6 3 0 0 3 3 2 0 Tetratricopeptide repeat Pkinase PF00069.20 KOO34943.1 - 4e-32 111.3 0.0 1.1e-26 93.5 0.0 2.7 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34943.1 - 6.2e-14 51.6 0.0 2.4e-08 33.3 0.0 2.6 2 1 1 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.1 KOO34943.1 - 0.00051 19.1 0.0 0.0033 16.4 0.0 1.9 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.9 KOO34943.1 - 0.003 16.6 0.1 0.0076 15.3 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Histone PF00125.19 KOO34945.1 - 9.2e-34 115.4 0.3 1.4e-33 114.8 0.2 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 KOO34945.1 - 0.00019 21.5 0.0 0.00029 20.9 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 KOO34945.1 - 0.0031 17.5 0.0 0.0062 16.5 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T PF15511.1 KOO34945.1 - 0.02 14.1 0.4 0.03 13.5 0.3 1.5 1 1 0 1 1 1 0 Centromere kinetochore component CENP-T Ribosomal_S19 PF00203.16 KOO34946.1 - 9.3e-27 92.4 0.0 1.4e-26 91.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 FliH PF02108.11 KOO34946.1 - 0.07 13.0 0.0 0.092 12.6 0.0 1.1 1 0 0 1 1 1 0 Flagellar assembly protein FliH DNA_pol_A PF00476.15 KOO34947.1 - 1.8e-09 36.7 0.1 6.3e-07 28.3 0.0 2.0 1 1 1 2 2 2 2 DNA polymerase family A Herpes_IE68 PF02479.11 KOO34948.1 - 0.028 13.6 0.0 0.029 13.5 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus immediate early protein DUF2285 PF10074.4 KOO34948.1 - 0.12 12.7 0.1 0.14 12.4 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2285) IGF2_C PF08365.6 KOO34949.1 - 0.45 10.3 0.0 0.45 10.3 0.0 2.2 2 0 0 2 2 2 0 Insulin-like growth factor II E-peptide Kinesin PF00225.18 KOO34950.1 - 1.1e-82 277.5 0.0 1.3e-82 277.2 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain PUB PF09409.5 KOO34952.1 - 9e-12 44.5 0.0 2.7e-11 43.0 0.0 1.9 1 0 0 1 1 1 1 PUB domain UBA PF00627.26 KOO34952.1 - 1.2e-09 37.6 0.0 1.2e-09 37.6 0.0 3.2 3 0 0 3 3 3 1 UBA/TS-N domain CH PF00307.26 KOO34953.1 - 5.2e-21 74.7 0.0 4.9e-13 49.0 0.0 2.1 2 0 0 2 2 2 2 Calponin homology (CH) domain MFS_1 PF07690.11 KOO34954.1 - 4e-08 32.3 17.8 4e-08 32.3 12.4 2.2 1 1 0 2 2 2 2 Major Facilitator Superfamily HMG_box PF00505.14 KOO34955.1 - 2.8e-05 24.2 0.1 2.8e-05 24.2 0.0 1.9 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 KOO34955.1 - 0.00094 19.5 0.0 0.0021 18.3 0.0 1.6 1 0 0 1 1 1 1 HMG-box domain Orbi_NS1 PF01718.11 KOO34955.1 - 0.17 9.8 0.0 0.25 9.3 0.0 1.1 1 0 0 1 1 1 0 Orbivirus non-structural protein NS1, or hydrophobic tubular protein CDC45 PF02724.9 KOO34955.1 - 0.35 8.8 4.0 0.48 8.4 2.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.7 KOO34955.1 - 0.53 8.1 4.2 0.72 7.7 2.9 1.1 1 0 0 1 1 1 0 Nop14-like family Nucleoplasmin PF03066.10 KOO34955.1 - 0.79 9.2 5.7 1.3 8.5 3.9 1.2 1 0 0 1 1 1 0 Nucleoplasmin Sigma70_ner PF04546.8 KOO34955.1 - 1.7 8.2 5.3 3 7.4 3.7 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region NOA36 PF06524.7 KOO34955.1 - 2.7 7.1 7.0 4 6.6 4.8 1.2 1 0 0 1 1 1 0 NOA36 protein 2HCT PF03390.10 KOO34956.1 - 0.087 11.1 3.4 0.07 11.4 0.2 1.9 1 1 1 2 2 2 0 2-hydroxycarboxylate transporter family MMPL PF03176.10 KOO34956.1 - 1.2 7.7 6.1 2.5 6.7 4.2 1.4 1 0 0 1 1 1 0 MMPL family IQ PF00612.22 KOO34957.1 - 0.00024 20.4 1.6 0.00075 18.9 0.8 8.3 8 0 0 8 8 8 3 IQ calmodulin-binding motif PP2C PF00481.16 KOO34959.1 - 4.5e-42 144.2 0.0 5.9e-42 143.8 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 KOO34959.1 - 1.6e-06 27.6 0.8 2.4e-05 23.8 0.6 2.1 1 1 0 1 1 1 1 Protein phosphatase 2C Macoilin PF09726.4 KOO34960.1 - 3.2 5.9 7.6 4 5.6 5.2 1.1 1 0 0 1 1 1 0 Transmembrane protein EutB PF06751.6 KOO34962.1 - 0.0029 15.9 2.2 0.0052 15.1 1.5 1.3 1 0 0 1 1 1 1 Ethanolamine ammonia lyase large subunit (EutB) UPF0016 PF01169.14 KOO34964.1 - 1.8e-41 140.1 24.5 3.7e-22 78.2 3.8 2.4 3 0 0 3 3 3 2 Uncharacterized protein family UPF0016 TerC PF03741.11 KOO34964.1 - 0.00019 20.9 2.9 0.00019 20.9 2.0 2.2 2 0 0 2 2 2 1 Integral membrane protein TerC family DUF1761 PF08570.5 KOO34964.1 - 3.8 7.5 11.7 0.71 9.8 3.3 2.6 2 2 0 2 2 2 0 Protein of unknown function (DUF1761) HXXEE PF13787.1 KOO34964.1 - 5.8 7.3 10.1 3.4 8.0 4.5 2.4 2 2 0 2 2 2 0 Protein of unknown function with HXXEE motif Mur_ligase_M PF08245.7 KOO34965.1 - 6.7e-07 29.5 0.0 1.7e-06 28.2 0.0 1.6 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.16 KOO34965.1 - 0.00012 22.0 0.0 0.00044 20.2 0.0 2.0 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain Myb_DNA-binding PF00249.26 KOO34966.1 - 1.4e-24 85.8 2.0 1.4e-12 47.4 0.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO34966.1 - 7.3e-18 64.4 1.1 5.2e-08 32.8 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain DUF4096 PF13340.1 KOO34966.1 - 0.0072 16.1 1.8 1.1 9.2 0.2 2.7 2 0 0 2 2 2 2 Putative transposase of IS4/5 family (DUF4096) Myb_DNA-bind_5 PF13873.1 KOO34966.1 - 0.29 11.0 3.1 0.71 9.8 0.3 2.4 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain Pkinase PF00069.20 KOO34967.1 - 1.5e-29 102.9 0.0 2e-29 102.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34967.1 - 4.4e-24 84.9 0.0 5.8e-24 84.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.17 KOO34967.1 - 0.04 13.2 0.0 0.064 12.6 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Pkinase_Tyr PF07714.12 KOO34968.1 - 2.2e-48 164.5 0.0 3.1e-48 164.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 KOO34968.1 - 7.5e-43 146.5 0.0 1.2e-42 145.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain p450 PF00067.17 KOO34968.1 - 2.2e-09 36.3 0.0 3.2e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Kinase-like PF14531.1 KOO34968.1 - 0.0016 17.4 0.0 0.0026 16.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO34968.1 - 0.015 15.0 0.0 0.046 13.4 0.0 1.8 1 0 0 1 1 1 0 Phosphotransferase enzyme family Tmemb_40 PF10160.4 KOO34968.1 - 7 5.7 13.6 0.62 9.2 5.7 1.8 2 0 0 2 2 2 0 Predicted membrane protein Rieske PF00355.21 KOO34970.1 - 3.1e-13 49.0 0.1 4.5e-13 48.5 0.0 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Coronavirus_5 PF05528.6 KOO34971.1 - 0.52 10.1 2.3 0.72 9.7 0.6 1.9 1 1 1 2 2 2 0 Coronavirus gene 5 protein AP2 PF00847.15 KOO34974.1 - 1.4e-08 34.7 0.2 3.7e-05 23.7 0.0 4.5 5 1 1 6 6 6 2 AP2 domain IF3_N PF05198.11 KOO34974.1 - 0.073 13.0 4.3 5.2 7.0 0.0 3.0 2 1 0 2 2 2 0 Translation initiation factor IF-3, N-terminal domain AbrB-like PF14250.1 KOO34974.1 - 0.14 12.0 0.8 12 5.8 0.0 2.5 2 0 0 2 2 2 0 AbrB-like transcriptional regulator PepSY PF03413.14 KOO34974.1 - 0.17 12.5 2.2 8.4 7.1 0.0 3.1 3 0 0 3 3 3 0 Peptidase propeptide and YPEB domain AP2 PF00847.15 KOO34975.1 - 0.00077 19.5 3.2 0.00077 19.5 2.2 5.2 5 2 0 5 5 5 2 AP2 domain PriCT_1 PF08708.6 KOO34975.1 - 0.011 15.4 9.1 1 9.2 0.3 3.3 3 0 0 3 3 3 0 Primase C terminal 1 (PriCT-1) IF3_N PF05198.11 KOO34975.1 - 0.016 15.0 1.8 10 6.1 0.0 3.2 3 0 0 3 3 3 0 Translation initiation factor IF-3, N-terminal domain CedA PF10729.4 KOO34975.1 - 0.049 13.1 0.1 0.5 9.9 0.0 2.5 2 1 0 2 2 2 0 Cell division activator CedA Imm38 PF15599.1 KOO34975.1 - 0.13 11.8 0.0 0.42 10.1 0.0 1.8 2 0 0 2 2 2 0 Immunity protein 38 DUF2493 PF10686.4 KOO34975.1 - 6.6 6.3 7.8 0.68 9.5 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2493) MelC1 PF06236.6 KOO34975.1 - 9.3 6.2 16.8 0.14 12.1 0.6 3.5 2 1 2 4 4 4 0 Tyrosinase co-factor MelC1 DUF2360 PF10152.4 KOO34976.1 - 0.12 12.6 1.4 0.22 11.7 1.0 1.4 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) SynMuv_product PF06047.6 KOO34978.1 - 1.2e-45 153.5 2.2 1.7e-45 153.0 1.5 1.2 1 0 0 1 1 1 1 Ras-induced vulval development antagonist DnaJ PF00226.26 KOO34979.1 - 1.1e-21 76.3 0.2 1.8e-21 75.6 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain Sigma70_ner PF04546.8 KOO34979.1 - 0.016 14.8 0.1 0.035 13.7 0.1 1.6 1 0 0 1 1 1 0 Sigma-70, non-essential region Mito_carr PF00153.22 KOO34980.1 - 7.1e-33 112.1 8.7 1.2e-14 53.7 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF697 PF05128.7 KOO34980.1 - 0.13 11.7 0.2 0.27 10.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF697) Pentapeptide_4 PF13599.1 KOO34981.1 - 1.6e-22 79.0 0.0 0.00025 20.7 0.0 9.7 6 2 3 9 9 9 6 Pentapeptide repeats (9 copies) SinI PF08671.5 KOO34981.1 - 0.0067 15.8 2.6 0.76 9.2 0.0 4.9 5 0 0 5 5 5 1 Anti-repressor SinI Poly_export PF02563.11 KOO34981.1 - 0.19 11.5 0.6 29 4.5 0.0 4.0 3 0 0 3 3 3 0 Polysaccharide biosynthesis/export protein Ribosomal_L13e PF01294.13 KOO34981.1 - 2.4 7.6 8.4 13 5.1 0.0 6.3 7 3 2 9 9 9 0 Ribosomal protein L13e Chloroa_b-bind PF00504.16 KOO34982.1 - 4.6e-37 127.6 0.0 5.8e-37 127.3 0.0 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein DUF2317 PF10079.4 KOO34984.1 - 0.78 8.2 13.7 0.059 11.9 1.3 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2317) Pkinase PF00069.20 KOO34986.1 - 3.7e-09 36.1 0.0 7.1e-09 35.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO34986.1 - 1.6e-06 27.4 0.1 5.5e-06 25.6 0.1 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.15 KOO34986.1 - 0.024 14.2 0.0 0.069 12.7 0.0 1.7 1 1 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.18 KOO34986.1 - 0.038 13.7 0.0 0.063 13.0 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 KOO34986.1 - 0.081 11.9 0.5 0.18 10.8 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family UAA PF08449.6 KOO34987.1 - 1.3e-10 40.6 14.4 2.4e-10 39.8 10.0 1.3 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.15 KOO34987.1 - 3.2e-05 23.9 4.8 3.2e-05 23.9 3.3 2.5 2 1 0 2 2 2 2 EamA-like transporter family TPT PF03151.11 KOO34987.1 - 0.035 13.7 23.4 0.012 15.2 5.9 2.8 2 2 0 2 2 2 0 Triose-phosphate Transporter family Ank_5 PF13857.1 KOO34989.1 - 1.7e-10 40.7 0.1 2e-05 24.6 0.0 3.6 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO34989.1 - 1.3e-07 31.8 0.8 9.5e-05 22.6 0.2 3.2 2 2 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO34989.1 - 1.5e-07 31.7 0.0 0.005 17.3 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO34989.1 - 2.8e-07 30.0 0.1 0.015 15.0 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.1 KOO34989.1 - 1.6e-06 27.8 0.3 0.061 13.5 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeat Inhibitor_I53 PF11714.3 KOO34989.1 - 0.61 10.1 3.6 5.4 7.0 0.3 2.4 1 1 1 2 2 2 0 Thrombin inhibitor Madanin PIP5K PF01504.13 KOO34990.1 - 2.1e-38 131.8 0.0 5.9e-38 130.4 0.0 1.7 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase ART PF01129.13 KOO34991.1 - 3.4e-11 42.6 0.0 4.8e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase PRA-PH PF01503.12 KOO34991.1 - 0.12 12.6 1.3 0.26 11.5 0.9 1.5 1 0 0 1 1 1 0 Phosphoribosyl-ATP pyrophosphohydrolase DUF2413 PF10310.4 KOO34991.1 - 0.45 9.2 3.3 0.68 8.6 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) Myosin_head PF00063.16 KOO34993.1 - 3.2e-15 55.2 0.0 1.8e-08 32.9 0.0 2.2 2 0 0 2 2 2 2 Myosin head (motor domain) Mem_trans PF03547.13 KOO34993.1 - 2.8e-11 42.3 0.2 2.1e-10 39.4 0.0 2.1 2 0 0 2 2 2 1 Membrane transport protein LRR_6 PF13516.1 KOO34993.1 - 9.2e-07 28.3 0.1 0.38 10.9 0.0 3.8 3 0 0 3 3 3 2 Leucine Rich repeat Sugar_transport PF06800.7 KOO34993.1 - 0.00011 21.3 0.7 0.00011 21.3 0.5 3.1 3 0 0 3 3 3 1 Sugar transport protein DUF1632 PF07857.7 KOO34993.1 - 0.00098 18.4 3.1 0.00098 18.4 2.1 2.3 2 0 0 2 2 2 1 CEO family (DUF1632) LRR_4 PF12799.2 KOO34993.1 - 0.089 12.4 0.0 1.9 8.1 0.0 2.7 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO34993.1 - 0.11 12.5 0.0 22 5.5 0.0 3.6 3 0 0 3 3 3 0 Leucine Rich Repeat Beta-lactamase PF00144.19 KOO34994.1 - 2.9e-19 69.2 0.2 5.3e-19 68.4 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase AAT PF03417.11 KOO34995.1 - 3.8e-11 42.8 0.0 8e-11 41.8 0.0 1.4 1 1 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase DUF4407 PF14362.1 KOO34996.1 - 0.0092 14.9 0.9 0.01 14.8 0.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) RCC1 PF00415.13 KOO34998.1 - 2.9e-18 65.7 5.8 1.7e-07 31.3 0.1 4.7 4 1 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO34998.1 - 3.5e-14 51.9 19.0 6.2e-08 32.0 0.5 4.1 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat DUF2416 PF10315.4 KOO34999.1 - 1 9.6 4.6 1.1e+02 3.1 0.0 4.0 5 0 0 5 5 5 0 Protein of unknown function (DUF2416) DSHCT PF08148.7 KOO35001.1 - 1.7e-40 138.1 0.0 2.8e-40 137.4 0.0 1.3 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.24 KOO35002.1 - 3.3e-17 62.5 0.0 5.1e-17 61.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 KOO35002.1 - 0.08 12.7 0.3 1.4 8.6 0.2 2.2 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Guanylate_kin PF00625.16 KOO35003.1 - 3.1e-57 192.9 0.0 3.5e-57 192.8 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.1 KOO35003.1 - 1.9e-06 27.7 0.0 1.6e-05 24.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 KOO35003.1 - 0.00021 20.4 0.0 0.00024 20.3 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 KOO35003.1 - 0.00038 20.6 0.0 0.0012 19.0 0.0 1.8 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KOO35003.1 - 0.022 14.7 0.1 0.027 14.4 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Miro PF08477.8 KOO35003.1 - 0.029 14.8 0.0 0.052 14.0 0.0 1.5 1 1 0 1 1 1 0 Miro-like protein AAA_18 PF13238.1 KOO35003.1 - 0.032 14.5 0.2 0.19 12.0 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.1 KOO35003.1 - 0.035 14.9 0.2 0.057 14.2 0.1 1.6 1 1 0 1 1 1 0 AAA domain MobB PF03205.9 KOO35003.1 - 0.035 13.8 0.1 0.11 12.1 0.0 1.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Arch_ATPase PF01637.13 KOO35003.1 - 0.041 13.5 0.0 0.067 12.8 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase HopW1-1 PF15457.1 KOO35003.1 - 0.043 12.8 0.0 0.053 12.5 0.0 1.1 1 0 0 1 1 1 0 Type III T3SS secreted effector HopW1-1/HopPmaA AAA_29 PF13555.1 KOO35003.1 - 0.064 12.7 0.1 0.53 9.8 0.0 2.4 3 0 0 3 3 3 0 P-loop containing region of AAA domain DUF1895 PF08988.5 KOO35003.1 - 0.085 12.9 0.3 0.14 12.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1895) RNA_helicase PF00910.17 KOO35003.1 - 0.11 12.7 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Helicase_C PF00271.26 KOO35004.1 - 6.5e-06 25.9 0.0 2e-05 24.3 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF3516 PF12029.3 KOO35004.1 - 0.06 12.1 0.0 0.088 11.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3516) Paramyxo_PCT PF14320.1 KOO35005.1 - 0.16 10.8 1.5 0.25 10.2 0.5 1.6 1 1 0 1 1 1 0 Phosphoprotein P region PCT disordered Thioredoxin_8 PF13905.1 KOO35007.1 - 6.7e-29 99.8 0.0 2.8e-22 78.6 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin-like DUF3638 PF12340.3 KOO35007.1 - 2.4e-27 95.3 0.0 5.9e-27 94.1 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.3 KOO35007.1 - 2.3e-16 58.5 0.2 6.9e-14 50.6 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF3645) Thioredoxin_2 PF13098.1 KOO35007.1 - 1.3e-05 25.3 0.0 4.1e-05 23.7 0.0 1.9 1 0 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.16 KOO35007.1 - 7.9e-05 22.3 0.0 0.00026 20.6 0.0 1.9 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin PF00085.15 KOO35007.1 - 0.0003 20.4 0.0 0.0018 17.8 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin Redoxin PF08534.5 KOO35007.1 - 0.00046 19.7 0.0 0.0015 18.1 0.0 1.8 1 0 0 1 1 1 1 Redoxin Laminin_G_3 PF13385.1 KOO35007.1 - 0.071 13.3 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily SCO1-SenC PF02630.9 KOO35007.1 - 0.23 11.0 0.0 0.89 9.1 0.0 2.0 1 0 0 1 1 1 0 SCO1/SenC Terminase_6 PF03237.10 KOO35007.1 - 1.7 7.3 0.0 64 2.1 0.0 2.4 2 0 0 2 2 2 0 Terminase-like family DUF1681 PF07933.9 KOO35008.1 - 2.1e-44 150.9 0.0 2.8e-44 150.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) DUF104 PF01954.11 KOO35008.1 - 0.16 11.9 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF104 Mito_fiss_reg PF05308.6 KOO35009.1 - 0.0052 16.1 1.4 0.0052 16.1 1.0 1.9 2 0 0 2 2 2 1 Mitochondrial fission regulator SAM_2 PF07647.12 KOO35010.1 - 8.9e-25 86.3 0.1 2.9e-11 43.0 0.0 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 KOO35010.1 - 1.4e-24 86.0 0.3 4.1e-11 42.8 0.0 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) VOMI PF03762.12 KOO35010.1 - 0.017 15.1 0.2 6.5 6.6 0.1 2.9 1 1 0 2 2 2 0 Vitelline membrane outer layer protein I (VOMI) SAM_PNT PF02198.11 KOO35010.1 - 0.023 14.4 0.3 2.2 8.1 0.0 2.9 2 2 0 2 2 2 0 Sterile alpha motif (SAM)/Pointed domain LRR_4 PF12799.2 KOO35010.1 - 0.046 13.3 0.3 0.21 11.2 0.1 2.1 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) DUF2363 PF10155.4 KOO35011.1 - 3.7e-53 178.7 6.4 5.7e-53 178.1 4.4 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2363) Ribosomal_S27e PF01667.12 KOO35012.1 - 4.4e-29 99.7 6.8 5.3e-29 99.5 4.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 IBR PF01485.16 KOO35012.1 - 0.00027 20.7 1.0 0.00033 20.4 0.7 1.2 1 0 0 1 1 1 1 IBR domain zf-CSL PF05207.8 KOO35012.1 - 0.032 13.7 1.1 0.066 12.7 0.6 1.7 2 0 0 2 2 2 0 CSL zinc finger Nop PF01798.13 KOO35013.1 - 3.7e-39 133.4 0.3 1.3e-38 131.5 0.1 1.9 2 0 0 2 2 2 1 Putative snoRNA binding domain Prp31_C PF09785.4 KOO35013.1 - 8.1e-33 113.4 2.8 1.8e-32 112.3 1.9 1.6 1 0 0 1 1 1 1 Prp31 C terminal domain NOSIC PF08060.8 KOO35013.1 - 9.8e-17 60.5 0.1 1.8e-16 59.6 0.1 1.5 1 0 0 1 1 1 1 NOSIC (NUC001) domain IDH PF03971.9 KOO35014.1 - 0 1141.5 3.6 0 1141.4 2.5 1.0 1 0 0 1 1 1 1 Monomeric isocitrate dehydrogenase TPR_10 PF13374.1 KOO35015.1 - 4.8e-34 115.2 32.9 2e-09 37.0 0.4 7.3 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_12 PF13424.1 KOO35015.1 - 9e-30 102.4 18.0 5.3e-11 42.3 0.2 5.2 2 2 3 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.23 KOO35015.1 - 2.3e-08 33.2 3.3 0.085 12.5 0.0 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO35015.1 - 3.7e-07 29.4 6.0 0.038 13.7 0.0 5.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO35015.1 - 1e-06 28.1 5.5 0.22 11.5 0.0 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO35015.1 - 1.1e-06 28.6 25.7 0.13 12.9 0.1 7.1 4 3 3 7 7 7 3 Tetratricopeptide repeat TPR_4 PF07721.9 KOO35015.1 - 2.3e-06 27.4 29.9 0.00053 20.1 0.1 7.1 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO35015.1 - 5.2e-06 26.9 28.2 0.0027 18.3 2.0 6.5 3 2 2 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO35015.1 - 1.8e-05 24.5 2.4 0.77 10.1 0.0 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO35015.1 - 2.6e-05 24.4 19.6 0.003 17.8 0.8 5.5 4 1 2 6 6 6 2 Tetratricopeptide repeat Apc3 PF12895.2 KOO35015.1 - 7.4e-05 22.8 2.4 0.049 13.7 0.1 3.8 2 1 2 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.1 KOO35015.1 - 0.00067 19.2 9.5 0.06 13.0 0.2 4.2 4 1 0 5 5 5 2 TPR repeat Glyco_trans_4_4 PF13579.1 KOO35015.1 - 0.77 9.8 8.7 0.08 13.0 2.5 1.9 1 1 1 2 2 2 0 Glycosyl transferase 4-like domain MLANA PF14991.1 KOO35016.1 - 0.26 11.3 0.0 0.26 11.3 0.0 2.5 2 1 0 2 2 2 0 Protein melan-A HC2 PF07382.6 KOO35016.1 - 4 7.2 126.0 0.52 10.1 48.0 2.6 1 1 1 2 2 2 0 Histone H1-like nucleoprotein HC2 Melibiase PF02065.13 KOO35017.1 - 1.3e-11 43.8 0.1 1.5e-09 37.0 0.0 2.2 2 0 0 2 2 2 2 Melibiase Glyco_hydro_97 PF10566.4 KOO35017.1 - 0.036 13.1 0.0 0.071 12.1 0.0 1.5 2 0 0 2 2 2 0 Glycoside hydrolase 97 EF-hand_1 PF00036.27 KOO35018.1 - 1.8e-36 120.6 10.7 9.9e-06 24.5 0.0 10.7 11 0 0 11 11 11 6 EF hand EF-hand_6 PF13405.1 KOO35018.1 - 9.1e-36 118.5 16.0 0.00013 21.5 0.0 10.7 11 0 0 11 11 11 7 EF-hand domain EF-hand_7 PF13499.1 KOO35018.1 - 3.6e-29 100.7 12.6 9.5e-07 28.8 0.0 7.4 5 2 1 6 6 6 5 EF-hand domain pair EF-hand_5 PF13202.1 KOO35018.1 - 2.3e-20 70.9 8.9 0.0019 17.4 0.0 6.7 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.1 KOO35018.1 - 6e-16 57.7 19.3 0.0028 17.2 0.0 8.0 7 2 2 9 9 9 6 EF-hand domain pair DUF4473 PF14747.1 KOO35018.1 - 0.00013 22.1 0.2 3.2 8.0 0.0 4.7 5 1 1 6 6 5 1 Domain of unknown function (DUF4473) Endonuc-dimeris PF09124.5 KOO35018.1 - 0.013 15.0 0.9 1.4 8.5 0.0 4.1 5 0 0 5 5 5 0 T4 recombination endonuclease VII, dimerisation EF-hand_9 PF14658.1 KOO35018.1 - 0.02 14.8 0.4 1.9 8.4 0.0 4.0 3 0 0 3 3 3 0 EF-hand domain Sigma70_r1_1 PF03979.9 KOO35018.1 - 0.029 14.3 0.2 56 3.7 0.0 4.5 5 0 0 5 5 5 0 Sigma-70 factor, region 1.1 ASL_C PF08328.6 KOO35018.1 - 0.16 11.8 2.1 6.2 6.6 0.0 3.7 4 0 0 4 4 4 0 Adenylosuccinate lyase C-terminal HTH_19 PF12844.2 KOO35018.1 - 0.2 11.7 2.4 16 5.6 0.4 4.0 3 1 0 3 3 3 0 Helix-turn-helix domain DUF3329 PF11808.3 KOO35018.1 - 0.6 10.2 2.9 5.9 7.0 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3329) DUF3885 PF13021.1 KOO35018.1 - 1 9.1 8.4 8 6.2 0.0 4.2 5 0 0 5 5 5 0 Domain of unknown function (DUF3885) PRCC PF10253.4 KOO35019.1 - 2.1e-09 38.3 0.3 2.1e-09 38.3 0.2 2.2 3 1 0 3 3 3 1 Mitotic checkpoint regulator, MAD2B-interacting Epimerase PF01370.16 KOO35020.1 - 2.5e-40 138.4 0.0 3.4e-40 137.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 KOO35020.1 - 1.5e-10 40.2 0.0 2.2e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 KOO35020.1 - 4.3e-08 33.3 0.0 6.6e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding NAD_binding_4 PF07993.7 KOO35020.1 - 8.9e-06 24.8 0.0 0.0033 16.3 0.0 2.7 2 1 0 2 2 2 2 Male sterility protein NmrA PF05368.8 KOO35020.1 - 2.8e-05 23.4 0.0 6.1e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.12 KOO35020.1 - 0.0018 17.2 0.0 0.0029 16.5 0.0 1.5 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 KOO35020.1 - 0.002 17.1 0.0 0.096 11.5 0.0 2.3 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Abhydrolase_5 PF12695.2 KOO35021.1 - 3.7e-05 23.5 0.1 7.8e-05 22.4 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Ins145_P3_rec PF08709.6 KOO35022.1 - 6.9e-30 103.6 0.0 7.9e-30 103.4 0.0 1.0 1 0 0 1 1 1 1 Inositol 1,4,5-trisphosphate/ryanodine receptor ACT_3 PF10000.4 KOO35022.1 - 0.039 13.6 0.0 0.15 11.7 0.0 1.8 2 0 0 2 2 2 0 ACT domain MIR PF02815.14 KOO35022.1 - 0.12 11.9 0.0 0.48 9.9 0.0 1.8 1 1 1 2 2 2 0 MIR domain Ribonuc_red_sm PF00268.16 KOO35023.1 - 9.4e-112 372.6 0.0 1.1e-111 372.3 0.0 1.0 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain DUF3594 PF12165.3 KOO35023.1 - 0.061 12.9 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3594) EF-hand_1 PF00036.27 KOO35024.1 - 1.4e-18 64.7 0.7 0.0015 17.7 0.1 5.9 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.1 KOO35024.1 - 1.9e-15 55.2 6.0 0.061 13.2 0.0 6.6 6 0 0 6 6 6 4 EF-hand domain EF-hand_7 PF13499.1 KOO35024.1 - 4.7e-13 49.0 11.3 0.02 15.0 1.2 6.3 3 2 2 5 5 5 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO35024.1 - 7e-05 22.3 9.5 3.4 7.3 0.0 4.8 5 0 0 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO35024.1 - 0.048 13.0 4.9 28 4.2 0.1 4.5 5 0 0 5 5 5 0 EF hand HTH_3 PF01381.17 KOO35024.1 - 0.064 13.1 0.1 27 4.6 0.0 3.5 4 0 0 4 4 4 0 Helix-turn-helix EF-hand_7 PF13499.1 KOO35025.1 - 8.7e-21 73.8 10.6 1.9e-07 31.0 0.3 5.0 4 1 1 5 5 5 4 EF-hand domain pair EF-hand_1 PF00036.27 KOO35025.1 - 6.4e-17 59.4 25.7 1.9e-05 23.6 0.6 6.8 6 0 0 6 6 6 5 EF hand EF-hand_6 PF13405.1 KOO35025.1 - 2.5e-14 51.7 18.5 2.2e-05 23.9 0.6 7.0 7 0 0 7 7 7 3 EF-hand domain EF-hand_5 PF13202.1 KOO35025.1 - 6.2e-11 41.1 17.3 2.3e-05 23.5 1.4 5.5 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.1 KOO35025.1 - 1.4e-06 27.7 19.4 0.003 17.1 0.2 5.5 3 2 2 5 5 5 3 EF-hand domain pair Lipase_GDSL_2 PF13472.1 KOO35025.1 - 2.3e-05 24.6 0.0 9.1e-05 22.6 0.0 1.9 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family SPARC_Ca_bdg PF10591.4 KOO35025.1 - 0.023 14.7 0.1 9 6.3 0.0 3.1 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO35025.1 - 0.13 11.9 0.9 4.3 7.0 0.0 3.1 3 0 0 3 3 3 0 EF hand Bac_rhamnosid PF05592.6 KOO35026.1 - 8.3e-96 321.2 0.0 1.2e-95 320.6 0.0 1.2 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase Bac_rhamnosid_N PF08531.5 KOO35026.1 - 3e-18 65.9 0.0 4.8e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 Alpha-L-rhamnosidase N-terminal domain Gal_Lectin PF02140.13 KOO35026.1 - 0.0002 21.6 0.0 0.0004 20.6 0.0 1.5 1 0 0 1 1 1 1 Galactose binding lectin domain Diphthamide_syn PF01866.12 KOO35027.1 - 8.3e-42 143.4 0.0 1.8e-23 83.2 0.0 3.1 3 0 0 3 3 3 3 Putative diphthamide synthesis protein Thioesterase PF00975.15 KOO35028.1 - 9.7e-12 45.5 0.0 1.2e-11 45.2 0.0 1.1 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.2 KOO35028.1 - 8.5e-05 22.5 0.0 0.00011 22.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO35028.1 - 0.031 14.0 0.0 0.032 13.9 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF4440 PF14534.1 KOO35028.1 - 0.072 13.3 0.1 0.39 10.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4440) Pkinase PF00069.20 KOO35029.1 - 1.4e-54 184.9 0.0 1.9e-54 184.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO35029.1 - 3.8e-35 121.2 0.0 4.9e-35 120.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO35029.1 - 3.1e-09 36.2 0.0 1.3e-08 34.2 0.0 1.8 2 0 0 2 2 2 1 Kinase-like DUF1295 PF06966.7 KOO35031.1 - 2e-34 118.9 2.5 5.7e-34 117.4 1.8 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) Steroid_dh PF02544.11 KOO35031.1 - 0.0028 17.4 0.1 0.0066 16.2 0.1 1.7 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.8 KOO35031.1 - 0.16 12.0 2.9 0.21 11.6 0.1 2.6 2 1 0 2 2 2 0 Phospholipid methyltransferase HD_4 PF13328.1 KOO35032.1 - 9.5e-37 126.0 0.4 1.8e-36 125.1 0.3 1.5 1 0 0 1 1 1 1 HD domain HD PF01966.17 KOO35032.1 - 4.4e-07 29.9 0.0 1.8e-06 27.9 0.0 2.0 1 1 0 1 1 1 1 HD domain DEAD PF00270.24 KOO35033.1 - 7.9e-11 41.7 0.0 1.2e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 KOO35033.1 - 6.2e-06 26.1 0.0 8.4e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_34 PF13872.1 KOO35033.1 - 0.02 13.6 0.0 0.039 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 Exo_endo_phos PF03372.18 KOO35034.1 - 2.7e-18 66.8 0.0 3.6e-18 66.4 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF2475 PF10629.4 KOO35035.1 - 0.00028 21.0 8.8 1.5 9.1 0.2 4.8 4 0 0 4 4 4 2 Protein of unknown function (DUF2475) T4SS PF07996.6 KOO35035.1 - 4.2 7.1 9.2 5.7 6.7 6.3 1.2 1 0 0 1 1 1 0 Type IV secretion system proteins Nuc_rec_co-act PF08815.5 KOO35036.1 - 0.035 13.6 0.0 0.082 12.4 0.0 1.6 1 0 0 1 1 1 0 Nuclear receptor coactivator TrbC PF04956.8 KOO35036.1 - 1.3 9.0 4.4 0.74 9.8 0.1 2.2 2 0 0 2 2 2 0 TrbC/VIRB2 family Ras PF00071.17 KOO35038.1 - 2.4e-27 95.2 0.0 4.5e-27 94.4 0.0 1.4 1 1 0 1 1 1 1 Ras family WW PF00397.21 KOO35038.1 - 3.6e-07 29.9 1.7 7.9e-07 28.8 1.2 1.6 1 0 0 1 1 1 1 WW domain Miro PF08477.8 KOO35038.1 - 6.4e-07 29.8 0.0 1.1e-06 29.0 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO35038.1 - 0.00036 19.8 0.0 0.0033 16.6 0.0 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_22 PF13401.1 KOO35038.1 - 0.0086 16.2 0.0 0.028 14.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 KOO35038.1 - 0.037 13.6 0.0 0.074 12.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.22 KOO35038.1 - 0.19 12.0 0.0 0.37 11.0 0.0 1.4 1 0 0 1 1 1 0 ABC transporter PKD_channel PF08016.7 KOO35039.1 - 1.5e-20 73.0 7.5 2e-20 72.6 5.2 1.1 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.26 KOO35039.1 - 0.0002 20.6 14.9 0.00037 19.7 10.3 1.5 1 1 0 1 1 1 1 Ion transport protein DUF373 PF04123.8 KOO35039.1 - 0.0019 17.3 0.7 0.0025 16.9 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF373) Myelin-PO_C PF10570.4 KOO35039.1 - 0.041 13.9 1.2 0.075 13.1 0.9 1.4 1 0 0 1 1 1 0 Myelin-PO cytoplasmic C-term p65 binding region IncA PF04156.9 KOO35039.1 - 0.071 12.7 0.0 0.071 12.7 0.0 2.0 2 0 0 2 2 2 0 IncA protein Gal4_dimer PF03902.8 KOO35039.1 - 0.11 12.4 0.0 0.32 10.9 0.0 1.7 2 0 0 2 2 2 0 Gal4-like dimerisation domain PilX PF13681.1 KOO35039.1 - 0.16 12.5 0.1 1.2 9.6 0.0 2.3 2 0 0 2 2 2 0 Type IV pilus assembly protein PilX C-term Oxysterol_BP PF01237.13 KOO35040.1 - 5.3 5.4 5.3 8.3 4.7 3.7 1.3 1 0 0 1 1 1 0 Oxysterol-binding protein TPR_12 PF13424.1 KOO35042.1 - 4.7e-69 228.3 28.4 1.4e-17 63.3 0.4 4.7 2 1 4 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.1 KOO35042.1 - 1.3e-65 215.6 36.7 1.1e-12 47.3 0.4 7.2 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_1 PF00515.23 KOO35042.1 - 1.6e-23 81.2 12.2 0.0011 18.4 0.0 6.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_4 PF07721.9 KOO35042.1 - 6.2e-20 69.5 23.1 0.0042 17.3 0.5 8.4 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.12 KOO35042.1 - 6.8e-20 69.3 18.6 0.037 13.9 0.1 7.1 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.1 KOO35042.1 - 2.7e-15 54.9 3.0 0.28 11.0 0.0 6.7 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.1 KOO35042.1 - 4.4e-14 52.6 28.5 0.00081 20.0 1.3 6.4 1 1 6 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.1 KOO35042.1 - 6.3e-14 50.6 22.3 0.079 12.7 0.1 7.1 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_11 PF13414.1 KOO35042.1 - 1.2e-13 50.4 11.3 0.00043 19.8 0.5 5.2 3 3 1 4 4 4 3 TPR repeat TPR_17 PF13431.1 KOO35042.1 - 2.7e-11 42.7 16.9 1.3 9.4 0.0 7.6 10 0 0 10 10 7 5 Tetratricopeptide repeat TPR_3 PF07720.7 KOO35042.1 - 1.6e-09 37.3 0.0 4 7.3 0.0 6.5 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO35042.1 - 2.2e-07 31.1 18.6 0.018 15.3 0.2 5.0 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.1 KOO35042.1 - 4e-07 30.0 28.8 6.7 7.6 0.2 7.3 5 1 2 7 7 7 2 Tetratricopeptide repeat Osmo_CC PF08946.5 KOO35042.1 - 1.1e-06 28.4 0.4 5.3 7.1 0.0 5.3 5 0 0 5 5 5 1 Osmosensory transporter coiled coil ApoLp-III PF07464.6 KOO35042.1 - 0.0044 17.0 0.0 23 4.9 0.0 3.9 2 2 2 4 4 4 0 Apolipophorin-III precursor (apoLp-III) FTCD PF02971.9 KOO35042.1 - 0.018 14.6 0.1 8.5 6.0 0.0 2.9 1 1 2 3 3 3 0 Formiminotransferase domain TPR_6 PF13174.1 KOO35042.1 - 0.93 10.0 16.3 1.2e+02 3.4 0.0 6.6 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_21 PF09976.4 KOO35042.1 - 0.98 9.3 9.1 1.1e+02 2.7 0.0 5.3 3 1 2 5 5 5 0 Tetratricopeptide repeat MIT PF04212.13 KOO35042.1 - 1.7 8.5 7.5 44 4.0 0.0 4.0 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain PCMT PF01135.14 KOO35043.1 - 0.00028 20.4 0.0 0.00035 20.1 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.2 KOO35043.1 - 0.0081 16.7 0.0 0.01 16.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO35043.1 - 0.032 13.9 0.0 0.039 13.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 KOO35043.1 - 0.05 12.9 0.0 0.068 12.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain EF-hand_6 PF13405.1 KOO35044.1 - 6.3e-09 34.9 0.2 0.00094 18.8 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO35044.1 - 2.5e-07 29.5 0.2 0.0082 15.3 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO35044.1 - 0.00017 20.7 0.2 0.019 14.2 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO35044.1 - 0.00022 21.2 0.2 0.22 11.7 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO35044.1 - 0.0018 17.8 0.2 0.25 10.9 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair TGT_C1 PF14809.1 KOO35045.1 - 0.013 15.3 1.4 28 4.6 0.0 3.0 3 0 0 3 3 3 0 C1 domain of tRNA-guanine transglycosylase dimerisation Repressor_Mnt PF11423.3 KOO35045.1 - 0.021 14.1 2.6 14 5.1 0.0 3.4 3 0 0 3 3 3 0 Regulatory protein Mnt LVIVD PF08309.6 KOO35047.1 - 1.1e-121 395.5 129.3 1.5e-11 43.1 2.5 14.2 14 0 0 14 14 14 14 LVIVD repeat PSCyt3 PF07627.6 KOO35047.1 - 9.5e-13 47.9 1.4 0.33 10.8 0.0 9.4 10 0 0 10 10 10 1 Protein of unknown function (DUF1588) Beta_propel PF09826.4 KOO35047.1 - 5.8e-09 34.8 8.5 3.9 5.7 0.0 10.0 8 3 3 11 11 11 2 Beta propeller domain SBP56 PF05694.6 KOO35047.1 - 3e-05 22.7 0.1 0.31 9.4 0.0 5.8 3 2 1 7 7 7 1 56kDa selenium binding protein (SBP56) Chitin_bind_4 PF00379.18 KOO35047.1 - 0.027 14.7 46.4 26 5.2 0.1 13.2 13 1 1 14 14 14 0 Insect cuticle protein CAF1C_H4-bd PF12265.3 KOO35047.1 - 0.13 12.1 0.0 51 3.8 0.0 4.7 6 0 0 6 6 6 0 Histone-binding protein RBBP4 or subunit C of CAF1 complex DUF4440 PF14534.1 KOO35047.1 - 0.2 11.9 2.0 10 6.4 0.0 4.5 5 1 1 6 6 6 0 Domain of unknown function (DUF4440) Dynamin_N PF00350.18 KOO35048.1 - 1.3e-06 28.3 0.0 2e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Dynamin family U-box PF04564.10 KOO35048.1 - 9e-05 22.3 0.0 0.00016 21.5 0.0 1.4 1 0 0 1 1 1 1 U-box domain Miro PF08477.8 KOO35048.1 - 0.001 19.5 0.0 0.044 14.2 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein AAA_16 PF13191.1 KOO35048.1 - 0.032 14.2 0.7 0.52 10.2 0.0 2.0 1 1 1 2 2 2 0 AAA ATPase domain Arch_ATPase PF01637.13 KOO35048.1 - 0.032 13.9 0.0 0.057 13.1 0.0 1.4 1 1 0 1 1 1 0 Archaeal ATPase MobB PF03205.9 KOO35048.1 - 0.092 12.4 0.0 0.27 10.9 0.0 1.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B zf-Nse PF11789.3 KOO35048.1 - 0.12 11.8 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit SNF2_N PF00176.18 KOO35050.1 - 2.6e-38 131.5 0.0 1.3e-37 129.2 0.0 2.0 1 1 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 KOO35050.1 - 4.1e-10 39.4 0.0 1.5e-09 37.5 0.0 2.0 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO35050.1 - 7.5e-10 38.5 0.0 1.5e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO35050.1 - 4.3e-05 23.4 0.0 0.00014 21.7 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 KOO35050.1 - 0.011 15.8 0.0 0.028 14.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.4 KOO35050.1 - 0.035 13.0 0.0 0.059 12.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Pkinase PF00069.20 KOO35052.1 - 2.7e-41 141.4 0.0 6e-29 100.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO35052.1 - 2.6e-21 75.8 0.0 1.8e-13 50.2 0.0 2.7 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 KOO35052.1 - 0.11 11.4 0.0 0.22 10.4 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Mito_carr PF00153.22 KOO35054.1 - 3.7e-41 138.7 0.5 4.9e-17 61.4 0.0 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein adh_short PF00106.20 KOO35055.1 - 3.9e-12 46.4 1.7 5.6e-12 45.8 1.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 KOO35055.1 - 5.6e-08 32.8 0.0 6.2e-08 32.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 KOO35055.1 - 0.054 13.1 0.8 2.2 7.9 0.4 2.1 1 1 1 2 2 2 0 KR domain Cupin_8 PF13621.1 KOO35056.1 - 5.6e-14 52.2 0.0 4.2e-12 46.1 0.0 2.2 1 1 1 2 2 2 2 Cupin-like domain Cupin_4 PF08007.7 KOO35056.1 - 6.3e-05 22.3 0.1 0.00014 21.2 0.0 1.5 2 0 0 2 2 2 1 Cupin superfamily protein PP2C PF00481.16 KOO35057.1 - 1.8e-40 138.9 0.0 9.6e-32 110.3 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.7 KOO35057.1 - 0.087 12.5 0.1 0.24 11.0 0.0 1.7 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) WD40 PF00400.27 KOO35058.1 - 9.2e-85 275.7 25.9 3.6e-13 48.8 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat PD40 PF07676.7 KOO35058.1 - 2.1e-17 62.3 6.6 0.9 9.2 0.0 7.4 7 0 0 7 7 7 7 WD40-like Beta Propeller Repeat BBS2_Mid PF14783.1 KOO35058.1 - 1e-08 34.9 1.0 1.8 8.3 0.0 6.1 1 1 6 7 7 7 3 Ciliary BBSome complex subunit 2, middle region DUF3312 PF11768.3 KOO35058.1 - 6.2e-07 28.0 0.1 0.23 9.6 0.0 4.1 1 1 4 5 5 5 5 Protein of unknown function (DUF3312) Gmad1 PF10647.4 KOO35058.1 - 2.7e-05 23.6 0.4 0.3 10.4 0.0 5.2 1 1 2 4 4 4 2 Lipoprotein LpqB beta-propeller domain Osteoregulin PF07175.6 KOO35058.1 - 0.0002 21.2 0.5 2.7 7.8 0.0 4.1 2 2 3 5 5 5 2 Osteoregulin IKI3 PF04762.7 KOO35058.1 - 0.0099 13.7 1.3 0.13 10.0 0.4 2.8 1 1 2 3 3 3 2 IKI3 family AsnC_trans_reg PF01037.16 KOO35058.1 - 0.044 13.4 0.4 63 3.3 0.0 4.6 6 0 0 6 6 6 0 AsnC family DUF4467 PF14729.1 KOO35058.1 - 0.058 13.7 0.0 21 5.5 0.0 3.6 1 1 2 4 4 4 0 Domain of unknown function with cystatin-like fold (DUF4467) Dfp1_Him1_M PF08630.5 KOO35058.1 - 0.072 12.8 12.6 2.5 7.9 0.1 5.6 6 1 1 7 7 7 0 Dfp1/Him1, central region Proteasome_A_N PF10584.4 KOO35058.1 - 5.4 6.4 19.3 17 4.8 0.2 6.9 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature Clathrin PF00637.15 KOO35059.1 - 0.00089 18.8 0.0 0.0054 16.3 0.0 2.1 2 0 0 2 2 2 1 Region in Clathrin and VPS zf-RING_2 PF13639.1 KOO35059.1 - 0.018 14.8 1.4 0.018 14.8 1.0 2.1 2 0 0 2 2 2 0 Ring finger domain zf-rbx1 PF12678.2 KOO35059.1 - 0.17 12.0 0.4 0.53 10.4 0.1 1.9 2 0 0 2 2 2 0 RING-H2 zinc finger PTCB-BRCT PF12738.2 KOO35060.1 - 0.00079 19.2 0.0 0.0012 18.6 0.0 1.3 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.21 KOO35060.1 - 0.0053 16.8 0.0 0.0086 16.1 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain HSP70 PF00012.15 KOO35061.1 - 4.1e-135 451.0 4.8 4.1e-135 451.0 3.3 2.2 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 KOO35061.1 - 5.8e-11 41.5 0.6 5.8e-11 41.5 0.4 1.8 2 0 0 2 2 2 1 MreB/Mbl protein MRP-L28 PF09812.4 KOO35061.1 - 1.4 8.7 6.9 0.15 11.8 1.4 1.8 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L28 HECT PF00632.20 KOO35062.1 - 1.6e-25 89.9 0.0 1.9e-25 89.7 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Ank PF00023.25 KOO35064.1 - 0.0007 19.2 0.8 0.0018 17.9 0.1 2.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.2 KOO35064.1 - 0.0031 17.8 0.0 0.005 17.1 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO35064.1 - 0.0035 17.8 0.0 0.51 10.9 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO35064.1 - 0.013 15.6 0.0 0.03 14.5 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeat Destabilase PF05497.7 KOO35064.1 - 0.067 13.2 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Destabilase Na_trans_assoc PF06512.8 KOO35067.1 - 1 9.2 6.4 1.1 9.1 4.5 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated SRP40_C PF05022.7 KOO35068.1 - 0.061 13.8 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 SRP40, C-terminal domain MTH865 PF07747.6 KOO35069.1 - 0.016 14.8 6.1 40 3.9 0.0 5.1 5 0 0 5 5 5 0 MTH865-like family VCBS PF13517.1 KOO35070.1 - 1.9e-143 466.9 165.8 6.9e-14 51.9 3.0 14.2 2 2 12 14 14 14 14 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO35070.1 - 1.1e-76 250.9 153.8 2.1e-06 27.2 0.7 15.5 15 0 0 15 15 15 15 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO35070.1 - 6.1e-21 74.6 63.4 0.44 9.9 0.1 15.1 3 3 12 15 15 15 15 Insecticide toxin TcdB middle/N-terminal region DUF1117 PF06547.7 KOO35070.1 - 0.002 18.2 0.2 2.1e+02 2.0 0.0 7.0 8 1 0 9 9 9 0 Protein of unknown function (DUF1117) EF-hand_7 PF13499.1 KOO35071.1 - 4.1e-09 36.4 0.0 9.4e-08 32.0 0.1 2.7 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO35071.1 - 1.6e-07 30.5 0.9 0.0046 16.7 0.1 3.5 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.27 KOO35071.1 - 5.3e-06 25.3 0.9 0.0092 15.2 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO35071.1 - 0.001 18.3 0.1 0.001 18.3 0.0 2.8 3 0 0 3 3 3 1 EF hand SPARC_Ca_bdg PF10591.4 KOO35071.1 - 0.12 12.4 0.1 11 6.1 0.0 2.2 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Pentapeptide_4 PF13599.1 KOO35072.1 - 3.6e-17 61.9 10.4 1.5e-10 40.6 1.2 2.0 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide PF00805.17 KOO35072.1 - 2.2e-14 52.3 9.9 1.2e-07 30.7 1.4 3.2 1 1 1 3 3 3 3 Pentapeptide repeats (8 copies) Pentapeptide_3 PF13576.1 KOO35072.1 - 1.1e-07 31.5 0.9 0.00072 19.3 0.2 2.7 1 1 2 3 3 3 2 Pentapeptide repeats (9 copies) Pkinase PF00069.20 KOO35073.1 - 4e-44 150.7 0.0 5.1e-44 150.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO35073.1 - 1.5e-21 76.6 0.0 2e-21 76.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO35073.1 - 2e-08 33.5 0.0 3.3e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO35073.1 - 7.2e-05 22.6 0.1 0.00013 21.7 0.1 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family YukC PF10140.4 KOO35073.1 - 0.013 14.1 0.0 0.016 13.8 0.0 1.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Kdo PF06293.9 KOO35073.1 - 0.014 14.4 0.2 0.019 14.0 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family VPS9 PF02204.13 KOO35074.1 - 4.8e-19 68.3 0.0 1.5e-14 53.8 0.0 2.2 2 0 0 2 2 2 2 Vacuolar sorting protein 9 (VPS9) domain TT_ORF2 PF02957.10 KOO35074.1 - 4.5 7.9 7.9 0.59 10.8 1.8 2.3 2 1 0 2 2 2 0 TT viral ORF2 PhaG_MnhG_YufB PF03334.9 KOO35075.1 - 0.44 10.6 5.7 1.1 9.3 1.0 2.1 1 1 1 2 2 2 0 Na+/H+ antiporter subunit PPC PF04151.10 KOO35077.1 - 0.022 15.7 0.0 0.083 13.8 0.0 2.0 1 0 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain DUF4419 PF14388.1 KOO35078.1 - 2.7e-22 79.3 0.0 3.2e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) Glyco_transf_8 PF01501.15 KOO35079.1 - 7.5e-08 32.0 0.0 5.6e-07 29.1 0.0 2.2 1 1 0 1 1 1 1 Glycosyl transferase family 8 RMMBL PF07521.7 KOO35080.1 - 0.03 14.1 0.0 0.063 13.1 0.0 1.5 1 0 0 1 1 1 0 RNA-metabolising metallo-beta-lactamase GTP_CH_N PF12471.3 KOO35083.1 - 2.1e-137 454.9 0.0 1.4e-74 249.9 0.0 2.2 2 0 0 2 2 2 2 GTP cyclohydrolase N terminal Glyco_tranf_2_3 PF13641.1 KOO35087.1 - 6.6e-32 111.1 0.1 8.7e-32 110.7 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 KOO35087.1 - 6.9e-15 55.2 0.1 1.4e-14 54.2 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.21 KOO35087.1 - 2e-13 50.3 0.0 5.6e-13 48.9 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.1 KOO35087.1 - 1.6e-09 37.3 0.0 2.5e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.4 KOO35087.1 - 0.053 12.6 0.0 0.075 12.1 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase like family 2 DctQ PF04290.7 KOO35089.1 - 0.011 15.5 5.9 0.2 11.4 0.0 2.6 2 1 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component DUF3329 PF11808.3 KOO35089.1 - 1.5 8.9 5.7 2.2 8.3 0.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3329) CoA_binding_3 PF13727.1 KOO35089.1 - 4 7.2 7.6 2.3 8.0 2.8 1.9 2 0 0 2 2 2 0 CoA-binding domain RNase_Zc3h12a PF11977.3 KOO35090.1 - 8.9e-06 25.6 0.0 0.0015 18.3 0.0 2.7 2 0 0 2 2 2 2 Zc3h12a-like Ribonuclease NYN domain UIM PF02809.15 KOO35090.1 - 0.00088 18.6 1.4 0.00088 18.6 1.0 5.6 5 0 0 5 5 5 2 Ubiquitin interaction motif NAD_Gly3P_dh_C PF07479.9 KOO35091.1 - 2e-49 167.1 0.5 5e-49 165.8 0.3 1.6 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.18 KOO35091.1 - 1.4e-39 135.3 0.0 4.4e-39 133.7 0.0 1.7 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Semialdhyde_dh PF01118.19 KOO35091.1 - 0.00057 20.1 0.0 0.0012 19.1 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain F420_oxidored PF03807.12 KOO35091.1 - 0.0029 18.0 0.1 0.078 13.4 0.1 2.6 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Aha1_N PF09229.6 KOO35096.1 - 1.6e-11 44.2 0.0 2.4e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal cwf21 PF08312.7 KOO35096.1 - 2.8 7.8 6.0 0.55 10.1 1.4 1.9 2 0 0 2 2 2 0 cwf21 domain EF-hand_7 PF13499.1 KOO35099.1 - 2.1e-22 79.0 5.8 1.6e-10 40.9 0.4 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO35099.1 - 3.1e-22 76.1 13.2 1.9e-05 23.6 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO35099.1 - 4.2e-21 72.8 10.2 0.00017 21.2 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 KOO35099.1 - 3.1e-16 58.7 8.4 1.2e-08 34.4 0.1 3.9 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO35099.1 - 2.9e-11 42.1 21.2 0.0012 18.0 0.1 4.6 5 0 0 5 5 5 4 EF hand EF-hand_10 PF14788.1 KOO35099.1 - 0.014 15.0 6.8 15 5.2 0.0 4.1 3 1 1 4 4 4 0 EF hand SPARC_Ca_bdg PF10591.4 KOO35099.1 - 0.017 15.1 0.1 2.7 8.0 0.0 2.4 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region UPF0223 PF05256.7 KOO35099.1 - 0.047 13.7 0.0 0.3 11.2 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0223) Armet PF10208.4 KOO35099.1 - 0.12 12.0 0.0 17 5.0 0.0 2.7 2 1 1 3 3 3 0 Degradation arginine-rich protein for mis-folding LexA_DNA_bind PF01726.11 KOO35100.1 - 0.15 11.6 0.1 0.32 10.5 0.0 1.6 2 0 0 2 2 2 0 LexA DNA binding domain GCC2_GCC3 PF07699.8 KOO35101.1 - 1.1e-09 37.6 15.9 2.5e-08 33.3 2.2 3.5 2 1 1 3 3 3 2 GCC2 and GCC3 NCD3G PF07562.9 KOO35101.1 - 0.092 12.4 0.3 0.092 12.4 0.2 3.4 2 1 2 4 4 4 0 Nine Cysteines Domain of family 3 GPCR DUF2318 PF10080.4 KOO35101.1 - 3 7.6 5.9 30 4.4 0.0 2.5 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) RED_N PF07808.8 KOO35102.1 - 8.2e-30 103.7 0.0 2.5e-29 102.1 0.0 1.9 1 1 0 1 1 1 1 RED-like protein N-terminal region HHH_6 PF14579.1 KOO35106.1 - 0.097 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif Pkinase PF00069.20 KOO35109.1 - 4.7e-49 166.8 0.0 5.9e-49 166.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO35109.1 - 7.9e-44 149.6 0.0 1.4e-43 148.8 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO35109.1 - 0.00037 19.5 0.0 0.0005 19.1 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO35109.1 - 0.011 15.5 0.1 0.02 14.6 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family AAA_17 PF13207.1 KOO35110.1 - 3.2e-06 27.9 0.0 7.3e-06 26.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOO35110.1 - 3e-05 23.2 0.0 4.8e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_19 PF13245.1 KOO35110.1 - 0.00042 20.0 0.2 0.0015 18.2 0.0 2.2 2 0 0 2 2 2 1 Part of AAA domain AAA_18 PF13238.1 KOO35110.1 - 0.00092 19.5 0.1 0.0075 16.5 0.0 2.3 3 0 0 3 3 2 1 AAA domain ArgK PF03308.11 KOO35110.1 - 0.00099 17.9 0.0 0.0015 17.3 0.0 1.2 1 0 0 1 1 1 1 ArgK protein NB-ARC PF00931.17 KOO35110.1 - 0.001 18.0 0.1 0.0056 15.5 0.0 1.9 2 0 0 2 2 2 1 NB-ARC domain AAA_16 PF13191.1 KOO35110.1 - 0.0022 18.0 0.1 0.011 15.7 0.0 2.0 2 1 0 2 2 2 1 AAA ATPase domain PRK PF00485.13 KOO35110.1 - 0.0083 15.7 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_28 PF13521.1 KOO35110.1 - 0.015 15.2 0.2 0.04 13.8 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 KOO35110.1 - 0.016 15.0 0.1 0.036 13.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.9 KOO35110.1 - 0.028 13.4 0.0 0.038 12.9 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain AAA_29 PF13555.1 KOO35110.1 - 0.08 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.22 KOO35110.1 - 0.11 12.8 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 ABC transporter CoaE PF01121.15 KOO35110.1 - 0.12 11.7 0.2 0.22 10.8 0.1 1.4 1 0 0 1 1 1 0 Dephospho-CoA kinase AAA_31 PF13614.1 KOO35110.1 - 0.14 12.1 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA PF00004.24 KOO35110.1 - 0.14 12.3 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rubella_E2 PF05749.6 KOO35111.1 - 0.017 14.3 0.1 0.029 13.6 0.0 1.3 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 Scramblase PF03803.10 KOO35113.1 - 1.2e-22 80.0 0.0 5.5e-22 77.9 0.0 1.8 1 1 0 1 1 1 1 Scramblase AAA PF00004.24 KOO35114.1 - 0.0027 17.9 0.0 0.0037 17.4 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF4639 PF15479.1 KOO35116.1 - 1.5e-09 37.0 0.1 1.9e-09 36.7 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4639) LRR_6 PF13516.1 KOO35117.1 - 1.1e-07 31.1 0.1 0.046 13.8 0.0 3.7 3 0 0 3 3 3 2 Leucine Rich repeat DUF667 PF05018.8 KOO35117.1 - 0.00011 21.5 0.0 0.00017 20.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF667) Kelch_1 PF01344.20 KOO35119.1 - 1.2e-96 316.0 0.0 6.8e-17 60.7 0.0 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.1 KOO35119.1 - 1e-60 199.5 0.0 4.4e-10 39.2 0.0 6.3 1 1 5 6 6 6 6 Kelch motif Kelch_2 PF07646.10 KOO35119.1 - 1.4e-50 167.1 0.0 1.3e-08 34.2 0.0 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.1 KOO35119.1 - 1.2e-49 165.8 0.0 9.5e-08 31.6 0.0 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.1 KOO35119.1 - 4.4e-48 160.4 0.8 3.7e-09 36.5 0.0 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO35119.1 - 8.1e-24 83.1 0.9 0.0056 16.6 0.0 6.6 6 0 0 6 6 6 6 Kelch motif BACK PF07707.10 KOO35119.1 - 4.5e-18 64.9 0.0 7.9e-18 64.1 0.0 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.26 KOO35119.1 - 1.4e-15 57.2 0.0 2.2e-15 56.6 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF1668 PF07893.8 KOO35119.1 - 3.5e-07 29.6 0.3 1.2 8.2 0.0 5.1 1 1 4 5 5 5 1 Protein of unknown function (DUF1668) PQQ_3 PF13570.1 KOO35119.1 - 3.7e-05 23.8 4.3 21 5.5 0.1 5.7 5 0 0 5 5 5 0 PQQ-like domain DUF721 PF05258.7 KOO35119.1 - 0.012 15.7 0.0 21 5.3 0.0 4.4 5 1 1 6 6 6 0 Protein of unknown function (DUF721) Skp1 PF01466.14 KOO35119.1 - 0.014 15.3 0.2 0.03 14.3 0.1 1.5 1 0 0 1 1 1 0 Skp1 family, dimerisation domain Filamin PF00630.14 KOO35120.1 - 4.1e-24 85.0 0.1 1.9e-15 57.2 0.0 2.4 2 0 0 2 2 2 2 Filamin/ABP280 repeat Kelch_4 PF13418.1 KOO35120.1 - 2.1e-17 62.5 1.6 2.8e-06 27.0 0.0 4.8 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.1 KOO35120.1 - 1.4e-16 60.1 2.7 2.5e-07 30.6 0.0 4.5 4 0 0 4 4 4 3 Galactose oxidase, central domain Laminin_G_3 PF13385.1 KOO35120.1 - 5.6e-15 55.9 0.0 3.4e-14 53.3 0.0 2.3 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Kelch_5 PF13854.1 KOO35120.1 - 1.5e-12 47.1 0.0 0.0089 15.9 0.0 4.8 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.1 KOO35120.1 - 3.8e-09 36.3 2.3 0.017 15.2 0.0 5.2 3 1 2 5 5 5 2 Kelch motif Kelch_1 PF01344.20 KOO35120.1 - 1.8e-08 33.7 0.0 0.035 13.6 0.0 4.0 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.10 KOO35120.1 - 0.0014 18.2 0.0 2.2 8.2 0.0 3.2 2 0 0 2 2 2 2 Kelch motif Laminin_G_2 PF02210.19 KOO35120.1 - 0.012 15.5 0.0 0.026 14.5 0.0 1.5 1 0 0 1 1 1 0 Laminin G domain Big_1 PF02369.11 KOO35120.1 - 0.054 13.3 0.0 1.8 8.5 0.0 2.6 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 1) Trypsin_2 PF13365.1 KOO35121.1 - 1.3e-10 41.2 0.7 2.1e-10 40.6 0.5 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ_2 PF13180.1 KOO35121.1 - 3.1e-09 36.5 0.0 9.1e-09 35.0 0.0 1.8 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.19 KOO35121.1 - 7.4e-08 32.4 0.0 3e-07 30.5 0.0 2.1 2 1 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) Trypsin PF00089.21 KOO35121.1 - 5e-07 29.5 0.1 6.8e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Trypsin Tricorn_PDZ PF14685.1 KOO35121.1 - 0.0041 16.8 0.1 0.017 14.8 0.0 2.1 2 0 0 2 2 2 1 Tricorn protease PDZ domain Peptidase_S29 PF02907.10 KOO35121.1 - 0.027 14.0 0.1 0.047 13.2 0.1 1.4 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Peptidase_S46 PF10459.4 KOO35121.1 - 0.11 10.9 1.7 0.15 10.4 0.8 1.4 2 0 0 2 2 2 0 Peptidase S46 Peptidase_S7 PF00949.16 KOO35121.1 - 0.11 11.8 0.4 0.23 10.8 0.3 1.5 2 0 0 2 2 2 0 Peptidase S7, Flavivirus NS3 serine protease Scramblase PF03803.10 KOO35122.1 - 4.8e-12 45.4 0.0 2.5e-08 33.2 0.0 2.5 2 1 0 2 2 2 2 Scramblase MOFRL PF05161.8 KOO35124.1 - 0.018 15.1 0.0 0.028 14.5 0.0 1.3 1 0 0 1 1 1 0 MOFRL family Radical_SAM PF04055.16 KOO35124.1 - 0.051 13.7 0.0 0.23 11.6 0.0 1.9 1 1 0 1 1 1 0 Radical SAM superfamily RasGAP_C PF03836.10 KOO35126.1 - 2e-07 30.8 8.2 6.4e-06 25.9 3.5 2.7 2 2 0 2 2 2 2 RasGAP C-terminus VitD-bind_III PF09164.5 KOO35126.1 - 0.11 12.1 2.5 4.9 6.8 0.0 3.4 4 0 0 4 4 4 0 Vitamin D binding protein, domain III BTB PF00651.26 KOO35127.1 - 9.6e-16 57.7 0.0 1.7e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Laminin_G_3 PF13385.1 KOO35127.1 - 0.0012 19.0 0.0 0.0021 18.3 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DHHA2 PF02833.9 KOO35128.1 - 4.6e-05 23.6 0.0 0.00011 22.4 0.0 1.7 2 1 0 2 2 2 1 DHHA2 domain AAA_6 PF12774.2 KOO35129.1 - 4.5e-21 75.4 0.2 7.1e-21 74.8 0.1 1.3 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 PapD-like PF14874.1 KOO35129.1 - 9e-13 48.0 0.3 0.041 13.8 0.0 8.2 9 1 1 10 10 10 3 Flagellar-associated PapD-like Motile_Sperm PF00635.21 KOO35129.1 - 4.9e-06 26.1 0.4 14 5.3 0.0 7.6 9 0 0 9 9 9 1 MSP (Major sperm protein) domain PapD_N PF00345.15 KOO35129.1 - 7.6e-06 25.7 0.0 6.4 6.5 0.0 6.0 8 0 0 8 8 8 2 Pili and flagellar-assembly chaperone, PapD N-terminal domain XG_FTase PF03254.8 KOO35130.1 - 8.3e-08 31.1 0.0 7.6e-07 27.9 0.0 2.0 2 0 0 2 2 2 2 Xyloglucan fucosyltransferase Thioredoxin_8 PF13905.1 KOO35132.1 - 1.1e-25 89.5 0.0 2.4e-25 88.4 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.16 KOO35132.1 - 4.9e-08 32.6 0.0 9.3e-08 31.8 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 KOO35132.1 - 2.1e-06 27.3 0.0 4.3e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Redoxin Thioredoxin_2 PF13098.1 KOO35132.1 - 2.8e-06 27.5 0.0 7.3e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin PF00085.15 KOO35132.1 - 8.8e-06 25.3 0.0 6.2e-05 22.6 0.0 2.0 1 1 1 2 2 2 1 Thioredoxin AAA PF00004.24 KOO35132.1 - 0.00018 21.7 0.0 0.00056 20.1 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF883 PF05957.8 KOO35132.1 - 0.017 15.5 0.5 0.052 13.9 0.3 1.8 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Amidohydro_2 PF04909.9 KOO35132.1 - 0.02 14.4 0.1 0.039 13.4 0.1 1.5 1 0 0 1 1 1 0 Amidohydrolase Thioredoxin_7 PF13899.1 KOO35132.1 - 0.056 13.4 0.0 0.19 11.7 0.0 2.0 1 1 0 1 1 1 0 Thioredoxin-like Flavodoxin_1 PF00258.20 KOO35133.1 - 7.1e-15 55.2 0.0 1.5e-13 50.9 0.0 2.3 1 1 0 1 1 1 1 Flavodoxin Ank_2 PF12796.2 KOO35133.1 - 1.3e-11 44.7 13.4 1.5e-05 25.2 1.1 3.7 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO35133.1 - 8.3e-11 41.7 12.0 0.00013 22.0 1.7 4.1 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO35133.1 - 1.7e-09 37.9 9.2 6.8e-05 23.2 1.1 3.9 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO35133.1 - 0.00017 21.2 26.3 0.0063 16.2 0.7 6.2 6 0 0 6 6 6 3 Ankyrin repeat Ank_3 PF13606.1 KOO35133.1 - 0.00033 20.6 14.1 2.4 8.6 0.0 5.7 4 1 0 4 4 4 2 Ankyrin repeat HR1 PF02185.11 KOO35134.1 - 0.01 15.5 1.8 0.013 15.2 1.2 1.3 1 0 0 1 1 1 0 Hr1 repeat SPX PF03105.14 KOO35134.1 - 0.047 13.4 0.7 0.048 13.4 0.5 1.1 1 0 0 1 1 1 0 SPX domain DUF4259 PF14078.1 KOO35134.1 - 0.071 13.6 6.6 0.085 13.3 4.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4259) DUF3987 PF13148.1 KOO35134.1 - 0.3 9.6 10.1 0.36 9.3 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Vfa1 PF08432.5 KOO35134.1 - 0.37 10.7 5.8 0.46 10.4 4.0 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF4407 PF14362.1 KOO35134.1 - 0.38 9.6 6.8 0.41 9.5 4.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Bap31 PF05529.7 KOO35134.1 - 0.39 10.1 6.6 0.45 9.9 4.6 1.1 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like Peptidase_S30 PF01577.11 KOO35134.1 - 0.43 9.9 2.3 0.44 9.8 1.6 1.0 1 0 0 1 1 1 0 Potyvirus P1 protease DUF812 PF05667.6 KOO35134.1 - 0.72 8.2 5.2 0.75 8.2 3.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) U79_P34 PF03064.11 KOO35134.1 - 1.1 8.7 3.9 1.2 8.6 2.7 1.0 1 0 0 1 1 1 0 HSV U79 / HCMV P34 DUF4355 PF14265.1 KOO35134.1 - 1.2 9.0 15.5 1.5 8.8 10.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) DUF3373 PF11853.3 KOO35134.1 - 1.3 7.5 4.0 1.4 7.3 2.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) DUF883 PF05957.8 KOO35134.1 - 1.5 9.2 10.1 2.5 8.5 7.0 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) DUF3584 PF12128.3 KOO35134.1 - 2.4 5.3 8.0 2.4 5.3 5.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF3515 PF12028.3 KOO35134.1 - 2.7 7.1 8.3 3.2 6.9 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3515) Carboxyl_trans PF01039.17 KOO35134.1 - 3.3 5.9 5.8 3.2 6.0 4.0 1.0 1 0 0 1 1 1 0 Carboxyl transferase domain DUF2894 PF11445.3 KOO35134.1 - 4.3 7.5 10.4 4.7 7.4 7.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) DUF3450 PF11932.3 KOO35134.1 - 4.9 6.3 8.9 5.4 6.2 6.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) ProSAAS PF07259.7 KOO35134.1 - 5.1 6.5 9.4 6 6.3 6.5 1.1 1 0 0 1 1 1 0 ProSAAS precursor DivIVA PF05103.8 KOO35134.1 - 6.2 6.8 12.2 7.6 6.6 8.4 1.2 1 0 0 1 1 1 0 DivIVA protein Cytochrom_B562 PF07361.6 KOO35134.1 - 8.4 6.8 10.1 9.2 6.7 4.4 1.9 1 1 1 2 2 2 0 Cytochrome b562 DUF3138 PF11336.3 KOO35134.1 - 9.9 4.2 9.8 11 4.0 6.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) GD_AH_C PF04295.8 KOO35135.1 - 2.6e-92 309.5 0.0 7.5e-69 232.2 0.0 4.7 3 1 1 4 4 4 3 D-galactarate dehydratase / Altronate hydrolase, C terminus NIF PF03031.13 KOO35135.1 - 2.3e-32 111.8 0.0 3.8e-32 111.1 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase SAF PF08666.7 KOO35135.1 - 2.3e-08 34.2 0.0 6.7e-08 32.8 0.0 1.9 1 0 0 1 1 1 1 SAF domain PKD_channel PF08016.7 KOO35137.1 - 3e-45 154.4 18.5 2.2e-36 125.2 14.4 2.3 2 0 0 2 2 2 2 Polycystin cation channel Ion_trans PF00520.26 KOO35137.1 - 5e-10 38.9 25.5 5e-10 38.9 17.7 1.7 2 0 0 2 2 2 1 Ion transport protein Exonuc_VII_L PF02601.10 KOO35137.1 - 0.2 10.7 8.3 0.41 9.7 5.8 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4618 PF15397.1 KOO35138.1 - 0.02 14.2 6.1 0.028 13.7 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) 3H PF02829.9 KOO35138.1 - 0.021 14.8 4.0 0.068 13.2 1.9 2.1 1 1 1 2 2 2 0 3H domain GLE1 PF07817.8 KOO35138.1 - 0.041 12.8 3.2 0.056 12.3 1.9 1.4 1 1 0 1 1 1 0 GLE1-like protein IF-2B PF01008.12 KOO35138.1 - 0.13 11.2 4.2 0.15 10.9 2.5 1.4 1 1 0 1 1 1 0 Initiation factor 2 subunit family LOH1CR12 PF10158.4 KOO35138.1 - 0.28 10.9 5.6 0.36 10.6 2.3 2.0 1 1 1 2 2 2 0 Tumour suppressor protein DUF1497 PF07384.6 KOO35138.1 - 0.29 11.3 1.8 0.62 10.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1497) SOXp PF12336.3 KOO35138.1 - 0.65 10.6 3.5 2.7 8.6 1.6 2.2 1 1 1 2 2 2 0 SOX transcription factor PP2C_C PF07830.8 KOO35138.1 - 2.5 8.2 4.6 16 5.6 1.8 2.8 1 1 2 3 3 3 0 Protein serine/threonine phosphatase 2C, C-terminal domain EF-hand_6 PF13405.1 KOO35140.1 - 1.1e-22 77.8 3.6 5.2e-05 22.7 0.0 5.9 6 0 0 6 6 6 5 EF-hand domain EF-hand_7 PF13499.1 KOO35140.1 - 7.2e-22 77.3 0.5 4.4e-08 33.1 0.0 4.3 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO35140.1 - 1.1e-20 71.2 0.4 0.0018 17.4 0.0 5.9 6 0 0 6 6 6 5 EF hand EF-hand_8 PF13833.1 KOO35140.1 - 2.1e-15 56.0 0.8 9.4e-06 25.1 0.0 4.9 4 1 1 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.1 KOO35140.1 - 3.1e-15 54.7 0.3 0.00025 20.2 0.0 6.5 6 0 0 6 6 6 4 EF hand Ank_5 PF13857.1 KOO35140.1 - 1.7e-05 24.9 0.1 7.1e-05 22.9 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO35140.1 - 0.0069 16.8 0.0 0.029 14.8 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Peptidase_C1 PF00112.18 KOO35141.1 - 1.7e-51 175.1 0.0 2.7e-51 174.5 0.0 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Ank_2 PF12796.2 KOO35141.1 - 9.1e-25 86.8 11.7 2.2e-12 47.1 0.7 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) AMP-binding PF00501.23 KOO35141.1 - 6.9e-16 57.6 0.1 1.2e-15 56.8 0.1 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Ank PF00023.25 KOO35141.1 - 1.3e-15 56.3 5.4 0.0046 16.6 0.0 4.7 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.1 KOO35141.1 - 3.3e-14 52.5 5.3 2.3e-05 24.4 0.0 3.9 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO35141.1 - 1.7e-13 50.6 2.2 1.2e-06 28.8 0.3 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO35141.1 - 5.8e-11 41.5 4.2 0.012 15.7 0.0 4.9 4 0 0 4 4 4 3 Ankyrin repeat Peptidase_C1_2 PF03051.10 KOO35141.1 - 5.6e-05 21.8 0.3 0.02 13.4 0.0 2.3 2 0 0 2 2 2 2 Peptidase C1-like family AMP-binding_C PF13193.1 KOO35141.1 - 0.00013 22.8 0.1 0.00034 21.5 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Inhibitor_I29 PF08246.7 KOO35141.1 - 0.0013 18.9 0.1 0.002 18.3 0.0 1.3 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) PP-binding PF00550.20 KOO35141.1 - 0.041 14.1 0.0 0.096 12.9 0.0 1.6 1 0 0 1 1 1 0 Phosphopantetheine attachment site Bestrophin PF01062.16 KOO35142.1 - 4.1e-38 130.9 3.2 5.1e-38 130.6 2.2 1.0 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Acyl-CoA_dh_M PF02770.14 KOO35143.1 - 2.5e-05 23.7 0.2 4.6e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain CPSase_L_D2 PF02786.12 KOO35144.1 - 1.1e-15 57.5 0.1 2.8e-15 56.1 0.0 1.6 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.14 KOO35144.1 - 8e-15 54.7 0.0 2.3e-14 53.2 0.0 1.9 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Pkinase PF00069.20 KOO35145.1 - 3e-24 85.5 0.0 8e-24 84.1 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain PARP PF00644.15 KOO35145.1 - 3.9e-15 55.8 0.0 1.2e-14 54.2 0.0 1.9 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Pkinase_Tyr PF07714.12 KOO35145.1 - 9.7e-12 44.5 0.3 2.2e-11 43.3 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Meleagrin PF08189.6 KOO35145.1 - 0.097 12.1 0.8 0.18 11.3 0.5 1.4 1 0 0 1 1 1 0 Meleagrin/Cygnin family Med15 PF09606.5 KOO35145.1 - 2.5 6.2 16.3 4.4 5.3 11.3 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PDZ_2 PF13180.1 KOO35146.1 - 0.0012 18.7 0.0 0.0041 16.9 0.0 1.9 2 0 0 2 2 2 1 PDZ domain GRASP55_65 PF04495.9 KOO35146.1 - 0.0082 16.1 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain PDZ PF00595.19 KOO35146.1 - 0.026 14.6 0.0 0.046 13.8 0.0 1.5 1 0 0 1 1 1 0 PDZ domain (Also known as DHR or GLGF) Lipocalin PF00061.18 KOO35146.1 - 0.092 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family SHIPPO-rpt PF07004.7 KOO35147.1 - 0.33 11.9 7.6 12 6.9 0.0 4.7 4 1 1 5 5 5 0 Sperm-tail PG-rich repeat DUF587 PF04532.7 KOO35148.1 - 0.046 12.6 0.1 0.071 12.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF587) THF_DHG_CYH_C PF02882.14 KOO35148.1 - 0.071 12.1 0.5 0.11 11.5 0.3 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain PhaP_Bmeg PF09602.5 KOO35148.1 - 0.097 12.4 5.7 0.35 10.6 1.1 2.2 1 1 1 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Alpha-2-MRAP_C PF06401.6 KOO35148.1 - 0.34 10.7 6.2 0.36 10.6 0.4 2.4 1 1 2 3 3 3 0 Alpha-2-macroglobulin RAP, C-terminal domain Birna_RdRp PF04197.7 KOO35148.1 - 0.44 8.5 9.0 0.53 8.2 6.2 1.1 1 0 0 1 1 1 0 Birnavirus RNA dependent RNA polymerase (VP1) Ank_2 PF12796.2 KOO35150.1 - 1.6e-67 223.8 27.0 7.1e-12 45.5 0.4 6.6 2 1 4 6 6 6 6 Ankyrin repeats (3 copies) Ank PF00023.25 KOO35150.1 - 6.5e-66 215.0 29.7 5.1e-08 32.3 0.1 12.7 12 0 0 12 12 12 12 Ankyrin repeat Ank_5 PF13857.1 KOO35150.1 - 5.9e-45 150.2 26.0 2.5e-06 27.5 0.0 10.5 2 2 7 10 10 10 10 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO35150.1 - 6.3e-45 150.7 14.7 4.1e-08 33.5 0.0 7.3 5 1 2 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO35150.1 - 9.5e-43 139.9 15.2 4.4e-05 23.3 0.0 12.6 12 0 0 12 12 12 10 Ankyrin repeat AAA_25 PF13481.1 KOO35150.1 - 1.6e-05 24.4 0.6 0.00015 21.2 0.2 2.6 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 KOO35150.1 - 4.4e-05 23.1 0.1 0.00013 21.6 0.0 1.8 1 1 0 1 1 1 1 NACHT domain Transketolase_N PF00456.16 KOO35151.1 - 5.8e-111 370.5 0.6 8.3e-111 369.9 0.4 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.19 KOO35151.1 - 3.1e-41 140.8 0.1 6.8e-41 139.6 0.0 1.6 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain DXP_synthase_N PF13292.1 KOO35151.1 - 9.6e-09 34.5 0.3 3.1e-05 23.0 0.1 2.8 1 1 1 2 2 2 2 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.15 KOO35151.1 - 3.6e-07 29.1 0.2 6.3e-07 28.3 0.1 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.16 KOO35151.1 - 1.4e-05 24.7 1.7 0.00016 21.2 1.0 2.8 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Transketolase_C PF02780.15 KOO35151.1 - 1.7e-05 24.7 0.5 9.2e-05 22.3 0.1 2.2 2 0 0 2 2 2 1 Transketolase, C-terminal domain Cauli_VI PF01693.11 KOO35153.1 - 1.5e-08 34.5 0.2 2.3e-08 33.9 0.2 1.3 1 0 0 1 1 1 1 Caulimovirus viroplasmin RNase_H PF00075.19 KOO35153.1 - 2.7e-07 30.9 0.2 1.3e-06 28.7 0.1 2.0 1 1 0 1 1 1 1 RNase H CobW_C PF07683.9 KOO35154.1 - 4.2e-07 29.5 0.0 1.1e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain DUF4091 PF13320.1 KOO35154.1 - 0.0035 17.1 0.0 0.0075 16.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4091) EF-hand_6 PF13405.1 KOO35155.1 - 2.3e-11 42.5 0.6 9.7e-06 25.0 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO35155.1 - 4.2e-11 41.3 2.3 5.3e-05 22.2 0.2 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO35155.1 - 5e-09 36.1 0.2 1.1e-08 35.1 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO35155.1 - 1.3e-08 33.8 1.3 0.00076 18.7 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO35155.1 - 1e-06 28.2 1.9 0.00019 20.9 0.3 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.1 KOO35155.1 - 0.0044 16.9 0.0 0.0095 15.8 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.2 KOO35155.1 - 0.13 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand p25-alpha PF05517.7 KOO35156.1 - 0.00032 20.9 0.0 0.00055 20.2 0.0 1.4 1 0 0 1 1 1 1 p25-alpha GLE1 PF07817.8 KOO35157.1 - 3.1e-29 101.6 0.1 3.9e-29 101.3 0.1 1.1 1 0 0 1 1 1 1 GLE1-like protein Herpes_US9 PF06072.6 KOO35157.1 - 0.098 12.4 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 ATP-synt_ab_C PF00306.22 KOO35159.1 - 2.6e-24 85.8 0.5 3.6e-24 85.4 0.4 1.4 1 1 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain RCC1 PF00415.13 KOO35160.1 - 6.4e-29 99.9 12.1 2.4e-09 37.2 0.0 5.3 4 2 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO35160.1 - 2e-11 43.1 27.4 4.7e-05 22.8 3.2 4.3 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat DUF2009 PF09418.5 KOO35161.1 - 3.6e-165 550.1 0.0 4.2e-165 549.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) CTP_transf_1 PF01148.15 KOO35162.1 - 1.4e-50 172.4 12.0 1.8e-50 172.0 8.3 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family Choline_transpo PF04515.7 KOO35163.1 - 6.6e-36 123.7 5.5 6.6e-36 123.7 3.8 3.1 2 1 2 4 4 4 1 Plasma-membrane choline transporter PARP PF00644.15 KOO35164.1 - 2.8e-36 124.9 0.0 2.8e-25 88.9 0.0 2.5 2 0 0 2 2 2 2 Poly(ADP-ribose) polymerase catalytic domain Pkinase PF00069.20 KOO35164.1 - 5.1e-22 78.2 0.0 1e-21 77.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO35164.1 - 1.2e-11 44.2 0.0 2e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO35164.1 - 8.1e-06 25.0 0.0 8.1e-06 25.0 0.0 3.3 3 1 0 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family Dimer_Tnp_Tn5 PF02281.11 KOO35165.1 - 0.034 14.2 0.8 3.7 7.7 0.1 2.1 1 1 1 2 2 2 0 Transposase Tn5 dimerisation domain Ribosomal_L13e PF01294.13 KOO35165.1 - 0.042 13.3 1.1 6.1 6.2 0.0 2.8 1 1 2 3 3 3 0 Ribosomal protein L13e CBM_3 PF00942.13 KOO35165.1 - 0.082 12.9 1.2 28 4.8 0.2 3.2 1 1 0 2 2 2 0 Cellulose binding domain FerB PF08150.7 KOO35165.1 - 0.31 11.1 2.9 0.43 10.6 0.3 1.9 1 1 0 2 2 2 0 FerB (NUC096) domain DUF3726 PF12525.3 KOO35165.1 - 0.42 10.4 4.3 10 6.0 0.3 2.8 1 1 1 3 3 3 0 Protein of unknown function (DUF3726) Pyr_redox_dim PF02852.17 KOO35165.1 - 0.55 10.2 3.9 9.1 6.3 0.6 3.1 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain DUF1191 PF06697.7 KOO35165.1 - 0.99 8.1 4.8 1.7 7.4 0.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1191) N_methyl_2 PF13544.1 KOO35165.1 - 1.7 8.2 5.9 20 4.9 0.1 4.5 4 3 2 6 6 6 0 Type IV pilin N-term methylation site GFxxxE DUF780 PF05611.6 KOO35165.1 - 4.1 8.1 10.8 12 6.6 3.6 2.6 1 1 1 2 2 2 0 Caenorhabditis elegans protein of unknown function (DUF780) DDE_1 PF03184.14 KOO35166.1 - 5.8e-06 25.5 0.0 1.1e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF2505 PF10698.4 KOO35167.1 - 5.1e-05 22.8 0.0 6.9e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2505) PX PF00787.19 KOO35168.1 - 2e-10 40.4 0.1 2.9e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 PX domain Urb2 PF10441.4 KOO35170.1 - 1.7e-11 44.1 0.0 1.9e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Urb2/Npa2 family Glyco_transf_15 PF01793.11 KOO35174.1 - 2e-05 23.7 0.3 3e-05 23.1 0.2 1.2 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase IPK PF03770.11 KOO35175.1 - 5e-14 52.3 0.0 8.6e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 Inositol polyphosphate kinase Pkinase PF00069.20 KOO35175.1 - 1.9e-12 46.9 0.0 2.7e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain LRR_6 PF13516.1 KOO35175.1 - 5.1e-08 32.1 0.1 0.062 13.3 0.0 3.9 3 0 0 3 3 3 2 Leucine Rich repeat Pkinase_Tyr PF07714.12 KOO35175.1 - 0.031 13.3 0.0 0.061 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase LRR_7 PF13504.1 KOO35175.1 - 0.13 12.5 0.0 1e+02 3.8 0.0 3.8 3 0 0 3 3 3 0 Leucine rich repeat NACHT PF05729.7 KOO35177.1 - 1.7e-08 34.3 0.0 6.5e-08 32.4 0.0 2.0 2 0 0 2 2 1 1 NACHT domain FtsK_SpoIIIE PF01580.13 KOO35177.1 - 0.00015 21.2 1.5 0.0074 15.7 0.0 3.8 4 1 0 4 4 4 1 FtsK/SpoIIIE family AAA_22 PF13401.1 KOO35177.1 - 0.00027 21.0 1.5 0.0055 16.8 0.0 3.9 3 1 0 3 3 3 1 AAA domain T2SE PF00437.15 KOO35177.1 - 0.0022 16.9 0.2 0.019 13.8 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_17 PF13207.1 KOO35177.1 - 0.003 18.3 0.0 0.012 16.4 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOO35177.1 - 0.0032 17.4 0.2 0.0032 17.4 0.1 4.5 3 2 0 3 3 2 1 AAA ATPase domain Viral_helicase1 PF01443.13 KOO35177.1 - 0.0066 15.9 0.0 0.018 14.5 0.0 1.7 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase G-alpha PF00503.15 KOO35177.1 - 0.0088 14.7 0.0 0.031 12.9 0.0 1.9 2 0 0 2 2 2 1 G-protein alpha subunit ATP_bind_1 PF03029.12 KOO35177.1 - 0.02 14.4 0.3 0.085 12.3 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MobB PF03205.9 KOO35177.1 - 0.021 14.5 0.1 0.18 11.5 0.0 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B KAP_NTPase PF07693.9 KOO35177.1 - 0.021 13.8 0.6 0.13 11.2 0.0 2.5 2 0 0 2 2 2 0 KAP family P-loop domain Spidroin_MaSp PF11260.3 KOO35177.1 - 0.022 14.8 0.6 0.096 12.7 0.4 2.1 1 0 0 1 1 1 0 Major ampullate spidroin 1 and 2 AAA_18 PF13238.1 KOO35177.1 - 0.023 15.0 0.4 0.099 12.9 0.0 2.5 3 0 0 3 3 1 0 AAA domain AAA_29 PF13555.1 KOO35177.1 - 0.024 14.1 0.0 0.062 12.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain PPV_E1_C PF00519.12 KOO35177.1 - 0.056 12.0 0.0 0.11 11.1 0.0 1.3 1 0 0 1 1 1 0 Papillomavirus helicase Pox_A32 PF04665.7 KOO35177.1 - 0.07 12.4 0.0 0.15 11.3 0.0 1.5 1 0 0 1 1 1 0 Poxvirus A32 protein DUF2075 PF09848.4 KOO35177.1 - 0.087 11.7 0.1 0.66 8.8 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) KaiC PF06745.8 KOO35177.1 - 0.097 11.7 0.2 1.1 8.3 0.0 2.7 3 0 0 3 3 3 0 KaiC Miro PF08477.8 KOO35177.1 - 0.12 12.8 0.0 0.4 11.1 0.0 2.0 1 1 0 1 1 1 0 Miro-like protein RNA_helicase PF00910.17 KOO35177.1 - 0.14 12.3 0.0 0.95 9.6 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA_10 PF12846.2 KOO35177.1 - 0.16 11.3 6.8 0.84 9.0 0.0 3.2 3 1 0 3 3 3 0 AAA-like domain DUF87 PF01935.12 KOO35177.1 - 0.7 9.6 4.0 2.1 8.1 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function DUF87 AAA_23 PF13476.1 KOO35177.1 - 2 8.7 7.2 9 6.5 0.0 3.7 3 1 0 3 3 3 0 AAA domain Condensin2nSMC PF12422.3 KOO35178.1 - 3.6e-46 156.6 0.7 5.1e-45 152.9 0.0 2.8 3 1 0 3 3 3 1 Condensin II non structural maintenance of chromosomes subunit HEAT_EZ PF13513.1 KOO35178.1 - 0.0097 16.3 0.8 0.0097 16.3 0.5 5.7 4 1 1 5 5 5 1 HEAT-like repeat HEAT PF02985.17 KOO35178.1 - 0.015 15.3 12.0 0.074 13.1 0.3 5.1 5 0 0 5 5 5 0 HEAT repeat Adaptin_N PF01602.15 KOO35178.1 - 0.019 13.3 0.0 0.066 11.5 0.0 1.8 1 1 0 1 1 1 0 Adaptin N terminal region Spindle_Spc25 PF08234.7 KOO35180.1 - 6.9e-20 70.8 0.0 1.6e-19 69.6 0.0 1.6 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 Spc7 PF08317.6 KOO35180.1 - 0.0055 15.4 7.8 0.009 14.7 5.4 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein SUKH-4 PF14435.1 KOO35180.1 - 0.018 14.7 0.2 0.33 10.6 0.0 2.5 3 0 0 3 3 3 0 SUKH-4 immunity protein FlaC_arch PF05377.6 KOO35180.1 - 0.5 10.2 9.9 2 8.3 0.3 4.1 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) ADIP PF11559.3 KOO35180.1 - 0.83 9.5 15.0 0.35 10.7 8.3 1.7 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Atg14 PF10186.4 KOO35180.1 - 2.7 6.8 14.0 4.4 6.1 9.7 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Phage_GPO PF05929.6 KOO35180.1 - 2.8 7.1 11.4 1.9 7.6 6.4 1.5 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Transposase_22 PF02994.9 KOO35180.1 - 3 6.2 12.1 10 4.5 0.0 2.5 2 1 0 2 2 2 0 L1 transposable element APG6 PF04111.7 KOO35180.1 - 3.5 6.5 13.4 5.6 5.9 9.3 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 HALZ PF02183.13 KOO35180.1 - 7.6 6.3 14.1 0.69 9.6 0.7 3.9 5 0 0 5 5 5 0 Homeobox associated leucine zipper NDK PF00334.14 KOO35181.1 - 1.1e-33 115.9 0.0 6.4e-33 113.4 0.0 1.9 1 1 0 1 1 1 1 Nucleoside diphosphate kinase Mpv17_PMP22 PF04117.7 KOO35184.1 - 5.4e-05 22.7 0.2 5.4e-05 22.7 0.1 2.3 2 0 0 2 2 2 1 Mpv17 / PMP22 family HET PF06985.6 KOO35185.1 - 0.12 12.5 0.3 0.8 9.8 0.0 2.5 2 1 1 3 3 3 0 Heterokaryon incompatibility protein (HET) Pectate_lyase_3 PF12708.2 KOO35187.1 - 0.023 14.7 0.3 0.028 14.5 0.2 1.1 1 0 0 1 1 1 0 Pectate lyase superfamily protein Peptidase_S8 PF00082.17 KOO35188.1 - 1.3e-11 44.1 0.0 1.7e-11 43.7 0.0 1.5 1 1 0 1 1 1 1 Subtilase family B12-binding PF02310.14 KOO35188.1 - 0.16 11.8 1.1 0.87 9.4 0.0 2.6 3 1 1 4 4 4 0 B12 binding domain PT PF04886.7 KOO35188.1 - 0.5 9.7 10.0 1.1 8.6 6.9 1.5 1 0 0 1 1 1 0 PT repeat Arm PF00514.18 KOO35190.1 - 2e-36 122.5 17.3 7.2e-09 35.1 0.2 5.5 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat U-box PF04564.10 KOO35190.1 - 5.8e-14 51.8 0.5 2.6e-13 49.7 0.0 2.3 4 0 0 4 4 4 1 U-box domain Arm_2 PF04826.8 KOO35190.1 - 2.4e-07 30.1 0.0 0.007 15.4 0.0 3.3 1 1 2 3 3 3 3 Armadillo-like zf-Nse PF11789.3 KOO35190.1 - 4.7e-06 26.0 0.0 9e-06 25.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Atx10homo_assoc PF09759.4 KOO35190.1 - 4.3e-05 23.1 0.2 0.58 9.9 0.0 3.4 1 1 3 4 4 4 3 Spinocerebellar ataxia type 10 protein domain zf-RING_UBOX PF13445.1 KOO35190.1 - 0.0072 16.0 0.0 0.023 14.4 0.0 1.9 1 0 0 1 1 1 1 RING-type zinc-finger Succ_CoA_lig PF13607.1 KOO35190.1 - 0.47 10.0 11.0 1.4 8.4 0.5 3.7 1 1 3 4 4 4 0 Succinyl-CoA ligase like flavodoxin domain U-box PF04564.10 KOO35191.1 - 1.6e-05 24.7 0.0 2.6e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 U-box domain Miro PF08477.8 KOO35191.1 - 0.0027 18.1 0.0 0.076 13.5 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein Dynamin_N PF00350.18 KOO35191.1 - 0.013 15.2 0.1 0.02 14.7 0.0 1.3 1 0 0 1 1 1 0 Dynamin family Arch_ATPase PF01637.13 KOO35191.1 - 0.03 14.0 0.0 0.051 13.2 0.0 1.5 1 1 0 1 1 1 0 Archaeal ATPase zf-Nse PF11789.3 KOO35191.1 - 0.078 12.5 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit AAA_16 PF13191.1 KOO35191.1 - 0.086 12.8 0.5 0.52 10.2 0.0 2.0 1 1 1 2 2 2 0 AAA ATPase domain MobB PF03205.9 KOO35191.1 - 0.12 12.1 0.1 0.4 10.3 0.0 1.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Ank PF00023.25 KOO35193.1 - 8.7e-25 85.2 0.1 3.2e-08 32.9 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.2 KOO35193.1 - 1.5e-21 76.5 0.0 1.2e-14 54.3 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO35193.1 - 8.5e-18 62.6 0.0 8.6e-05 22.4 0.0 3.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 KOO35193.1 - 2.3e-17 62.5 0.0 6.1e-05 23.1 0.0 3.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO35193.1 - 2.4e-14 53.3 0.0 4.8e-07 30.1 0.0 3.2 2 1 1 3 3 3 3 Ankyrin repeats (many copies) HELP PF03451.9 KOO35194.1 - 1.1e-14 53.6 0.2 1.6e-14 53.1 0.1 1.2 1 0 0 1 1 1 1 HELP motif YjgP_YjgQ PF03739.9 KOO35195.1 - 5.6 5.6 6.5 9.7 4.8 4.5 1.3 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family WD40 PF00400.27 KOO35196.1 - 3.5e-29 99.6 16.2 0.019 14.8 0.0 9.8 10 0 0 10 10 10 9 WD domain, G-beta repeat PD40 PF07676.7 KOO35196.1 - 0.17 11.6 2.6 12 5.7 0.1 3.8 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat DUF4613 PF15390.1 KOO35196.1 - 0.26 9.4 0.0 0.37 8.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) CTDII PF01556.13 KOO35197.1 - 0.071 13.0 0.1 13 5.7 0.0 3.2 3 1 1 4 4 4 0 DnaJ C terminal domain CbtA PF09490.5 KOO35197.1 - 0.13 11.5 0.2 0.19 10.9 0.2 1.2 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) Adaptin_N PF01602.15 KOO35198.1 - 6.3e-112 374.5 5.0 8.4e-112 374.1 3.5 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.5 KOO35198.1 - 5.3e-42 143.1 0.0 1.6e-41 141.6 0.0 1.8 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain HEAT_2 PF13646.1 KOO35198.1 - 2.4e-13 50.1 3.1 0.045 14.0 0.0 6.0 3 2 3 6 6 6 4 HEAT repeats HEAT_EZ PF13513.1 KOO35198.1 - 0.00017 21.9 13.0 0.023 15.2 0.1 5.6 5 1 1 6 6 6 1 HEAT-like repeat HEAT PF02985.17 KOO35198.1 - 0.00052 19.8 10.6 5.5 7.3 0.0 6.4 7 0 0 7 7 7 1 HEAT repeat Cnd1 PF12717.2 KOO35198.1 - 0.0026 17.6 7.3 0.5 10.1 0.1 4.0 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 KaiC PF06745.8 KOO35198.1 - 0.014 14.5 0.0 0.032 13.3 0.0 1.6 1 0 0 1 1 1 0 KaiC UNC45-central PF11701.3 KOO35198.1 - 0.024 14.3 0.5 11 5.5 1.0 3.5 1 1 1 2 2 2 0 Myosin-binding striated muscle assembly central Cnd3 PF12719.2 KOO35198.1 - 0.064 12.2 3.6 5.5 5.8 0.0 3.4 4 1 0 4 4 4 0 Nuclear condensing complex subunits, C-term domain RICTOR_M PF14666.1 KOO35198.1 - 0.066 12.2 0.4 0.33 9.9 0.0 2.4 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, middle domain LSM14 PF12701.2 KOO35200.1 - 7.7e-34 115.3 0.0 8.4e-34 115.2 0.0 1.0 1 0 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.1 KOO35200.1 - 4.8e-07 29.6 0.0 5.7e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain Ank_2 PF12796.2 KOO35201.1 - 9.2e-41 138.0 0.2 8.8e-16 58.0 0.1 4.6 4 0 0 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 KOO35201.1 - 6.2e-36 120.4 5.2 2.1e-05 24.0 0.0 8.5 8 0 0 8 8 8 7 Ankyrin repeat Ank_5 PF13857.1 KOO35201.1 - 2.8e-25 87.7 8.7 0.00012 22.2 0.1 8.3 5 2 3 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO35201.1 - 1.2e-21 74.6 2.8 0.0055 16.8 0.0 8.2 8 0 0 8 8 8 5 Ankyrin repeat Ank_4 PF13637.1 KOO35201.1 - 4.4e-21 74.8 0.5 4.1e-06 27.1 0.0 5.9 4 2 1 5 5 5 4 Ankyrin repeats (many copies) DUF1682 PF07946.9 KOO35201.1 - 0.00017 20.5 7.4 0.00027 19.9 5.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) DnaJ PF00226.26 KOO35202.1 - 6.5e-19 67.4 1.3 1.5e-18 66.2 0.9 1.6 1 0 0 1 1 1 1 DnaJ domain Nucleotid_trans PF03407.11 KOO35203.1 - 1.1e-27 97.2 0.3 9.4e-27 94.1 0.2 2.1 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase PRT_C PF08372.5 KOO35203.1 - 0.037 13.5 0.1 0.08 12.4 0.0 1.5 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal O-FucT PF10250.4 KOO35203.1 - 0.077 12.0 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase F5_F8_type_C PF00754.20 KOO35204.1 - 3.4e-14 52.7 0.0 2.3e-12 46.8 0.0 2.5 2 0 0 2 2 2 2 F5/8 type C domain Hox9_act PF04617.8 KOO35205.1 - 0.087 12.9 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Hox9 activation region LEP503 PF15221.1 KOO35206.1 - 0.00038 20.1 0.0 1.7 8.4 0.0 3.1 3 0 0 3 3 3 2 Lens epithelial cell protein LEP503 Fmp27_SW PF10305.4 KOO35206.1 - 0.0027 18.1 0.7 0.39 11.1 0.0 2.5 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain YicC_N PF03755.8 KOO35206.1 - 0.0035 17.2 0.9 8.1 6.3 0.0 3.6 3 0 0 3 3 3 2 YicC-like family, N-terminal region T2SF PF00482.18 KOO35206.1 - 0.044 13.6 0.8 12 5.8 0.0 3.8 4 0 0 4 4 4 0 Type II secretion system (T2SS), protein F FUSC PF04632.7 KOO35206.1 - 0.065 11.6 2.5 4.4 5.6 0.1 2.6 2 0 0 2 2 2 0 Fusaric acid resistance protein family Tcell_CD4_Cterm PF12104.3 KOO35206.1 - 0.39 10.3 6.8 7.4 6.2 0.5 2.9 2 0 0 2 2 2 0 T cell CD4 receptor C terminal region EzrA PF06160.7 KOO35206.1 - 0.58 8.2 5.3 0.76 7.8 0.1 3.1 3 1 1 4 4 4 0 Septation ring formation regulator, EzrA RicinB_lectin_2 PF14200.1 KOO35207.1 - 0.0014 18.9 0.4 0.058 13.7 0.1 2.5 1 1 2 3 3 3 1 Ricin-type beta-trefoil lectin domain-like Runt PF00853.14 KOO35207.1 - 0.0072 15.7 0.1 0.16 11.4 0.0 2.1 1 1 1 2 2 2 1 Runt domain Orthopox_C10L PF07020.6 KOO35208.1 - 0.0096 16.4 0.9 0.016 15.7 0.6 1.3 1 0 0 1 1 1 1 Orthopoxvirus C10L protein LCE PF14672.1 KOO35209.1 - 9.1 6.8 6.7 5.3 7.6 0.5 2.5 2 1 1 3 3 3 0 Late cornified envelope Coprogen_oxidas PF01218.13 KOO35212.1 - 2.7e-128 426.6 0.2 3.3e-128 426.3 0.1 1.1 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase ShK PF01549.19 KOO35213.1 - 8.5e-07 29.2 6.8 8.5e-07 29.2 4.7 2.2 3 0 0 3 3 3 1 ShK domain-like RWD PF05773.17 KOO35215.1 - 1.4e-06 28.1 0.0 2e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 RWD domain EF-hand_7 PF13499.1 KOO35216.1 - 5.3e-11 42.4 0.2 1.5e-10 41.0 0.1 1.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO35216.1 - 6.2e-09 34.5 0.1 7.2e-06 24.9 0.0 3.0 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.1 KOO35216.1 - 1.7e-08 33.6 0.2 1.1e-05 24.9 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO35216.1 - 6.3e-08 31.6 0.6 0.00014 21.0 0.1 2.5 2 0 0 2 2 2 2 EF hand PDZ PF00595.19 KOO35216.1 - 3.3e-05 23.9 0.0 0.0001 22.3 0.0 1.8 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO35216.1 - 0.00023 20.9 0.0 0.00056 19.7 0.0 1.6 1 0 0 1 1 1 1 PDZ domain EF-hand_8 PF13833.1 KOO35216.1 - 0.00025 20.5 0.2 0.0017 17.9 0.0 2.4 2 1 1 3 3 3 2 EF-hand domain pair Mito_carr PF00153.22 KOO35218.1 - 1.7e-35 120.6 9.7 2.7e-19 68.6 0.3 4.7 3 2 0 3 3 3 3 Mitochondrial carrier protein Lipase_chap PF03280.9 KOO35219.1 - 0.086 12.3 0.1 0.14 11.6 0.1 1.3 1 0 0 1 1 1 0 Proteobacterial lipase chaperone protein Synaptobrevin PF00957.16 KOO35220.1 - 3.6e-16 58.5 0.1 6e-16 57.8 0.0 1.4 1 0 0 1 1 1 1 Synaptobrevin Trichoplein PF13868.1 KOO35221.1 - 1e-31 109.6 58.7 1e-31 109.6 40.7 2.1 2 0 0 2 2 2 1 Tumour suppressor, Mitostatin Phage-MuB_C PF09077.6 KOO35221.1 - 0.0011 18.6 4.7 0.28 10.8 0.1 3.2 2 1 1 3 3 3 2 Mu B transposition protein, C terminal DUF2508 PF10704.4 KOO35221.1 - 0.0022 18.1 3.7 0.0022 18.1 2.5 3.8 2 2 2 4 4 4 1 Protein of unknown function (DUF2508) MetJ PF01340.15 KOO35221.1 - 0.21 11.3 5.9 0.17 11.6 0.5 2.6 2 1 0 2 2 2 0 Met Apo-repressor, MetJ NHL PF01436.16 KOO35222.1 - 2.5e-38 128.1 5.6 1.9e-08 33.8 0.0 5.5 5 0 0 5 5 5 5 NHL repeat BTB PF00651.26 KOO35222.1 - 1e-19 70.5 0.0 2.3e-19 69.4 0.0 1.6 1 1 1 2 2 2 1 BTB/POZ domain SGL PF08450.7 KOO35222.1 - 2e-15 56.8 10.7 0.00016 21.1 0.1 4.7 3 2 2 5 5 5 4 SMP-30/Gluconolaconase/LRE-like region DUF839 PF05787.8 KOO35222.1 - 1.2e-10 40.9 2.8 0.011 14.7 0.1 3.8 1 1 3 4 4 4 3 Bacterial protein of unknown function (DUF839) IN_DBD_C PF00552.16 KOO35222.1 - 0.0036 16.6 0.0 1.5 8.3 0.0 3.4 3 0 0 3 3 3 1 Integrase DNA binding domain SBBP PF06739.6 KOO35222.1 - 0.012 15.4 4.5 12 5.7 0.0 4.8 5 0 0 5 5 5 0 Beta-propeller repeat Ldl_recept_b PF00058.12 KOO35222.1 - 0.04 14.2 2.6 37 4.7 0.0 4.8 5 0 0 5 5 5 0 Low-density lipoprotein receptor repeat class B SdiA-regulated PF06977.6 KOO35222.1 - 0.047 12.6 0.0 8.5 5.2 0.0 2.6 2 0 0 2 2 2 0 SdiA-regulated DUF3342 PF11822.3 KOO35222.1 - 0.057 12.5 0.0 0.15 11.2 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3342) Phytase-like PF13449.1 KOO35222.1 - 0.084 12.1 0.0 7.5 5.7 0.0 2.4 2 0 0 2 2 2 0 Esterase-like activity of phytase Tcp10_C PF07202.8 KOO35222.1 - 0.16 11.5 0.0 4.2 6.8 0.0 2.4 2 1 0 2 2 2 0 T-complex protein 10 C-terminus SAP30_Sin3_bdg PF13867.1 KOO35222.1 - 0.19 11.6 0.0 0.34 10.7 0.0 1.3 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 EF-hand_1 PF00036.27 KOO35223.1 - 9.3e-28 93.3 7.3 2.2e-07 29.6 0.3 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO35223.1 - 4.5e-23 81.1 1.4 1.5e-10 41.0 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO35223.1 - 7.5e-23 78.7 4.9 5.5e-05 22.3 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO35223.1 - 7.9e-21 72.0 0.3 0.0012 18.5 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 KOO35223.1 - 1e-16 60.2 10.5 5.1e-06 25.9 0.3 4.4 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.1 KOO35223.1 - 2.1e-08 33.9 0.1 0.0002 21.1 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 KOO35223.1 - 1.3e-07 31.2 0.3 0.0082 15.8 0.0 3.2 3 0 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO35223.1 - 3.1e-06 27.1 0.0 0.096 12.7 0.0 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO35223.1 - 0.28 10.8 2.0 44 3.8 0.0 3.5 4 0 0 4 4 4 0 EF hand DUF4440 PF14534.1 KOO35223.1 - 0.8 9.9 3.8 6 7.1 0.5 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4440) DnaJ PF00226.26 KOO35224.1 - 6e-16 57.9 0.0 1.1e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 KOO35224.1 - 6.4e-16 58.0 0.0 1.8e-15 56.5 0.0 1.8 2 0 0 2 2 2 1 DnaJ C terminal domain AA_permease PF00324.16 KOO35228.1 - 2.3e-46 158.1 38.4 8.5e-46 156.2 26.6 1.9 1 1 0 1 1 1 1 Amino acid permease DUF2306 PF10067.4 KOO35228.1 - 6.5 6.9 13.8 3.3 7.9 4.8 3.4 2 1 0 2 2 2 0 Predicted membrane protein (DUF2306) DUF2862 PF11061.3 KOO35229.1 - 0.1 12.3 3.7 41 3.9 0.1 4.5 4 1 1 5 5 5 0 Protein of unknown function (DUF2862) DUF2740 PF10872.3 KOO35229.1 - 0.31 10.7 9.8 19 5.0 0.0 5.1 5 1 0 5 5 5 0 Protein of unknown function (DUF2740) LRR_6 PF13516.1 KOO35231.1 - 7.1e-43 139.8 17.9 0.0004 20.1 0.0 12.2 13 0 0 13 13 13 9 Leucine Rich repeat LRR_4 PF12799.2 KOO35231.1 - 1.7e-12 46.6 13.1 0.046 13.3 0.0 8.4 2 1 7 9 9 9 6 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO35231.1 - 3e-08 32.5 10.0 39 5.0 0.0 10.5 11 0 0 11 11 11 0 Leucine rich repeat LRR_1 PF00560.28 KOO35231.1 - 2.6e-06 26.7 2.7 70 4.0 0.0 9.3 11 1 0 11 11 11 0 Leucine Rich Repeat LRR_8 PF13855.1 KOO35231.1 - 0.00037 20.1 14.4 2.6 7.8 0.3 7.8 3 2 7 10 10 10 2 Leucine rich repeat DUF4396 PF14342.1 KOO35231.1 - 0.074 13.1 0.0 7.5 6.6 0.0 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4396) Qn_am_d_aIII PF09099.5 KOO35231.1 - 0.13 12.5 7.4 6.6 7.1 0.0 4.0 4 0 0 4 4 4 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain III YusW PF14039.1 KOO35231.1 - 0.16 12.2 4.5 19 5.6 0.0 4.3 3 1 2 5 5 5 0 YusW-like protein DUF2202 PF09968.4 KOO35231.1 - 0.17 11.5 5.1 11 5.6 0.1 4.4 1 1 3 5 5 5 0 Uncharacterized protein domain (DUF2202) CbiG_N PF11760.3 KOO35231.1 - 0.3 10.8 18.0 15 5.3 0.1 6.7 4 1 3 7 7 7 0 Cobalamin synthesis G N-terminal Ammonium_transp PF00909.16 KOO35232.1 - 4.6e-99 331.5 27.9 1.6e-98 329.8 19.4 1.6 1 1 0 1 1 1 1 Ammonium Transporter Family Glyco_hydro_3 PF00933.16 KOO35233.1 - 5.4e-63 212.7 0.0 7.4e-63 212.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.17 KOO35233.1 - 1.2e-15 57.6 0.4 1.5e-08 34.4 0.0 2.5 1 1 1 2 2 2 2 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 KOO35233.1 - 6.3e-09 35.6 0.2 1.4e-08 34.5 0.1 1.6 1 1 0 1 1 1 1 Fibronectin type III-like domain WD40 PF00400.27 KOO35235.1 - 5e-39 130.8 22.9 2.7e-09 36.5 0.1 7.4 8 0 0 8 8 8 6 WD domain, G-beta repeat DUF3337 PF11816.3 KOO35235.1 - 1.6e-33 116.5 0.0 3.1e-33 115.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) KLRAQ PF10205.4 KOO35235.1 - 0.0022 17.9 0.4 0.0057 16.6 0.3 1.6 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein Fez1 PF06818.10 KOO35235.1 - 0.0024 17.9 3.6 0.0024 17.9 2.5 1.6 2 0 0 2 2 2 1 Fez1 Nup160 PF11715.3 KOO35235.1 - 0.007 14.5 0.4 0.051 11.6 0.1 2.3 1 1 1 2 2 2 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 KOO35235.1 - 0.047 12.4 0.2 2.2 6.9 0.0 2.8 2 2 0 2 2 2 0 Nup133 N terminal like AAA_27 PF13514.1 KOO35235.1 - 0.17 9.5 15.4 0.25 8.9 10.6 1.1 1 0 0 1 1 1 0 AAA domain WXG100 PF06013.7 KOO35235.1 - 0.34 10.9 5.8 1.7 8.6 0.5 2.8 2 0 0 2 2 2 0 Proteins of 100 residues with WXG DivIC PF04977.10 KOO35235.1 - 0.54 9.7 7.5 0.038 13.4 1.3 1.9 2 0 0 2 2 2 0 Septum formation initiator DUF2570 PF10828.3 KOO35235.1 - 1.1 8.9 3.8 1.1 8.9 1.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) GAS PF13851.1 KOO35235.1 - 1.7 7.7 5.2 0.24 10.5 0.7 1.7 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding SLA_LP_auto_ag PF05889.8 KOO35236.1 - 2e-97 326.1 0.0 8e-53 179.3 0.0 2.0 1 1 1 2 2 2 2 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) Lactonase PF10282.4 KOO35239.1 - 1.8e-57 195.0 0.0 3.4e-55 187.5 0.0 2.3 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Cytotoxic PF09000.5 KOO35239.1 - 0.052 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Cytotoxic Topoisom_bac PF01131.15 KOO35242.1 - 1.2e-50 172.5 0.0 8.6e-40 136.7 0.0 3.1 2 1 1 3 3 3 3 DNA topoisomerase Rotamase PF00639.16 KOO35242.1 - 2.6e-16 60.1 1.6 1.3e-15 57.9 0.0 2.8 3 0 0 3 3 3 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 KOO35242.1 - 9.8e-14 51.6 0.0 2e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 PPIC-type PPIASE domain Toprim PF01751.17 KOO35242.1 - 5.8e-05 23.0 0.0 0.00017 21.5 0.0 1.8 1 1 0 1 1 1 1 Toprim domain Cellulase PF00150.13 KOO35245.1 - 6.8e-31 107.5 0.0 9.9e-31 106.9 0.0 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.12 KOO35245.1 - 0.0081 15.1 0.0 0.013 14.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain ALAD PF00490.16 KOO35246.1 - 5.3e-143 475.7 0.0 6.2e-143 475.5 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase EF-hand_1 PF00036.27 KOO35248.1 - 9.6e-14 49.5 0.7 1.4e-05 24.0 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO35248.1 - 7.2e-11 42.0 0.0 1.3e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO35248.1 - 1.6e-10 40.4 1.6 3.8e-07 29.6 0.1 2.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO35248.1 - 5.3e-09 35.2 0.1 0.00016 21.2 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO35248.1 - 8.3e-09 34.4 0.2 0.0023 17.1 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.2 KOO35248.1 - 0.048 13.4 0.0 0.21 11.3 0.0 1.9 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand DUF4381 PF14316.1 KOO35248.1 - 0.12 12.4 4.4 0.86 9.7 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) SPARC_Ca_bdg PF10591.4 KOO35248.1 - 0.16 11.9 0.0 0.28 11.2 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Filamin PF00630.14 KOO35249.1 - 4.9e-50 168.2 0.0 5.8e-14 52.4 0.0 7.3 7 0 0 7 7 7 7 Filamin/ABP280 repeat Arm PF00514.18 KOO35250.1 - 2.6e-15 55.5 8.3 1.5e-05 24.5 0.0 4.6 4 0 0 4 4 4 3 Armadillo/beta-catenin-like repeat SspK PF08176.7 KOO35250.1 - 0.014 15.4 0.1 0.077 13.0 0.0 2.2 2 0 0 2 2 2 0 Small acid-soluble spore protein K family HEAT_2 PF13646.1 KOO35250.1 - 0.019 15.2 4.6 0.051 13.8 0.4 2.7 3 1 0 3 3 3 0 HEAT repeats V-ATPase_H_N PF03224.9 KOO35250.1 - 0.084 11.9 0.0 0.2 10.7 0.0 1.6 2 0 0 2 2 2 0 V-ATPase subunit H Arm PF00514.18 KOO35251.1 - 1.4e-35 119.8 24.6 1.6e-05 24.5 0.0 12.6 12 1 0 12 12 12 9 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO35251.1 - 0.00014 22.0 3.5 0.007 16.6 0.1 6.1 2 2 3 6 6 6 3 HEAT repeats HEAT PF02985.17 KOO35251.1 - 0.056 13.5 8.1 0.18 11.9 0.0 5.2 6 0 0 6 6 6 0 HEAT repeat HEAT_EZ PF13513.1 KOO35251.1 - 9.6 6.8 20.5 12 6.5 0.2 5.9 5 1 0 5 5 5 0 HEAT-like repeat Ribosomal_S4 PF00163.14 KOO35252.1 - 3.7e-25 88.1 2.8 7.3e-25 87.1 1.9 1.5 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 KOO35252.1 - 2.6e-15 55.5 0.6 7e-15 54.1 0.4 1.8 1 0 0 1 1 1 1 S4 domain LRR_1 PF00560.28 KOO35253.1 - 5.3e-11 40.9 1.4 5.1 7.5 0.0 9.0 9 0 0 9 9 9 4 Leucine Rich Repeat LRR_4 PF12799.2 KOO35253.1 - 5.1e-09 35.5 8.8 0.35 10.5 0.1 6.9 8 0 0 8 8 8 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO35253.1 - 9.9e-07 28.2 19.2 0.14 12.3 0.0 8.9 11 0 0 11 11 11 2 Leucine Rich repeat LRR_8 PF13855.1 KOO35253.1 - 0.00043 19.9 5.5 13 5.6 0.2 6.3 6 1 1 7 7 7 3 Leucine rich repeat LRR_7 PF13504.1 KOO35253.1 - 0.0017 18.2 20.4 2.7 8.5 0.0 10.1 12 0 0 12 12 12 1 Leucine rich repeat Fasciclin PF02469.17 KOO35254.1 - 1.7e-10 40.9 0.0 2.8e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 Fasciclin domain WD40 PF00400.27 KOO35255.1 - 3e-35 118.8 16.9 3.4e-07 29.8 1.3 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat LRR_6 PF13516.1 KOO35255.1 - 2e-15 55.0 1.8 0.15 12.2 0.0 9.0 9 0 0 9 9 9 3 Leucine Rich repeat ATP-gua_PtransN PF02807.10 KOO35255.1 - 4.3e-15 55.6 0.0 8.6e-15 54.6 0.0 1.5 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain LRR_1 PF00560.28 KOO35255.1 - 2.1e-09 36.1 0.0 17 5.9 0.0 8.6 8 1 1 9 9 9 1 Leucine Rich Repeat SPRY PF00622.23 KOO35255.1 - 6.2e-07 29.5 0.1 1.3e-06 28.4 0.1 1.5 1 0 0 1 1 1 1 SPRY domain LRR_8 PF13855.1 KOO35255.1 - 6.1e-05 22.6 1.3 1.1 9.0 0.0 5.4 5 1 0 5 5 5 2 Leucine rich repeat LRR_4 PF12799.2 KOO35255.1 - 7.2e-05 22.3 0.1 2.7 7.7 0.0 6.1 6 1 0 6 6 6 1 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO35255.1 - 0.00096 18.9 21.8 6.9 7.3 0.0 9.7 11 0 0 11 11 11 2 Leucine rich repeat Shikimate_dh_N PF08501.6 KOO35256.1 - 7.8e-18 64.3 0.0 1.9e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Shikimate_DH PF01488.15 KOO35256.1 - 0.014 15.4 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase VPEP PF07589.6 KOO35256.1 - 0.3 11.0 2.5 0.87 9.5 1.7 1.8 1 0 0 1 1 1 0 PEP-CTERM motif LRR_6 PF13516.1 KOO35257.1 - 1e-19 68.3 1.3 0.0046 16.8 0.0 6.7 7 0 0 7 7 7 5 Leucine Rich repeat SAP PF02037.22 KOO35257.1 - 3.5e-09 35.9 0.1 1.2e-08 34.2 0.1 2.0 1 0 0 1 1 1 1 SAP domain LRR_4 PF12799.2 KOO35257.1 - 0.033 13.8 0.0 18 5.0 0.0 3.4 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) CbiG_N PF11760.3 KOO35257.1 - 3.7 7.3 10.7 35 4.1 0.1 4.1 3 1 0 3 3 3 0 Cobalamin synthesis G N-terminal DUF2358 PF10184.4 KOO35258.1 - 4.6e-07 29.7 0.0 7.1e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) LRR_6 PF13516.1 KOO35258.1 - 8.5e-06 25.3 0.1 0.0053 16.6 0.0 2.5 2 0 0 2 2 2 2 Leucine Rich repeat LRR_4 PF12799.2 KOO35258.1 - 0.00087 18.8 0.3 0.031 13.8 0.0 2.0 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO35258.1 - 0.0029 17.4 0.0 1.1 9.5 0.0 2.8 2 0 0 2 2 2 1 Leucine Rich Repeat LRR_7 PF13504.1 KOO35258.1 - 0.072 13.3 0.0 2 8.9 0.0 2.7 2 0 0 2 2 2 0 Leucine rich repeat LRR_6 PF13516.1 KOO35259.1 - 5.2e-09 35.2 4.9 0.034 14.2 0.0 6.9 7 0 0 7 7 7 2 Leucine Rich repeat WD40 PF00400.27 KOO35259.1 - 2e-08 33.7 0.1 0.012 15.4 0.0 3.7 3 1 0 3 3 3 2 WD domain, G-beta repeat LRR_1 PF00560.28 KOO35259.1 - 0.012 15.5 0.3 19 5.7 0.0 4.5 5 0 0 5 5 5 0 Leucine Rich Repeat EF-hand_1 PF00036.27 KOO35260.1 - 2.7e-20 70.0 7.5 7e-06 24.9 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO35260.1 - 4.2e-19 66.6 3.8 3.8e-05 23.2 0.2 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO35260.1 - 3.3e-17 62.3 1.9 1.5e-08 34.5 0.3 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO35260.1 - 4.1e-16 57.5 7.9 0.00062 18.9 0.4 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO35260.1 - 9e-09 34.8 8.3 0.001 18.6 0.1 4.0 3 1 1 4 4 4 2 EF-hand domain pair LRR_8 PF13855.1 KOO35260.1 - 1e-06 28.3 0.6 0.021 14.5 0.2 2.6 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.2 KOO35260.1 - 1.4e-06 27.8 1.2 0.025 14.2 0.0 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO35260.1 - 2.3e-05 23.8 0.7 10 6.6 0.0 4.7 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_7 PF13504.1 KOO35260.1 - 0.0047 16.9 4.4 19 5.9 0.1 4.2 3 0 0 3 3 3 0 Leucine rich repeat DUF4473 PF14747.1 KOO35260.1 - 0.14 12.4 1.2 0.38 10.9 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4473) Ydc2-catalyt PF09159.5 KOO35261.1 - 5e-05 22.9 2.3 6.3e-05 22.5 1.6 1.1 1 0 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 DUF3368 PF11848.3 KOO35261.1 - 0.11 12.0 0.1 1.2 8.7 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3368) RloB PF13707.1 KOO35261.1 - 0.38 10.3 6.3 0.27 10.8 1.8 1.9 1 1 1 2 2 2 0 RloB-like protein Vps16_C PF04840.7 KOO35262.1 - 1.3e-64 218.1 0.0 1.6e-64 217.8 0.0 1.0 1 0 0 1 1 1 1 Vps16, C-terminal region LSPR PF06049.7 KOO35263.1 - 0.11 11.8 0.8 3.6 7.4 0.1 2.8 2 0 0 2 2 2 0 Coagulation Factor V LSPD Repeat YqaJ PF09588.5 KOO35264.1 - 2.8e-11 43.6 0.0 4.5e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 YqaJ-like viral recombinase domain Filamin PF00630.14 KOO35267.1 - 5.2e-12 46.2 0.0 2.1e-08 34.6 0.0 2.4 2 0 0 2 2 2 2 Filamin/ABP280 repeat Dam PF05869.6 KOO35267.1 - 1e-05 25.0 0.0 2.1e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 DNA N-6-adenine-methyltransferase (Dam) Big_1 PF02369.11 KOO35267.1 - 0.011 15.5 0.4 0.19 11.6 0.3 2.5 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 1) ABC_tran PF00005.22 KOO35268.1 - 5.3e-42 143.3 0.0 5.5e-21 75.3 0.0 3.6 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 KOO35268.1 - 1.7e-17 64.3 0.5 0.00044 20.3 0.1 4.1 4 0 0 4 4 4 4 AAA domain HEAT PF02985.17 KOO35268.1 - 3.9e-09 35.8 4.2 0.0037 17.2 0.0 5.2 4 0 0 4 4 4 1 HEAT repeat AAA_15 PF13175.1 KOO35268.1 - 1.5e-08 34.1 0.1 0.0041 16.2 0.0 3.3 2 1 1 3 3 3 2 AAA ATPase domain SMC_N PF02463.14 KOO35268.1 - 5.5e-08 32.3 0.8 0.0077 15.4 0.1 3.8 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 KOO35268.1 - 1.6e-06 27.5 0.1 0.041 13.4 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 KOO35268.1 - 4.4e-06 25.9 0.0 0.01 15.0 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_25 PF13481.1 KOO35268.1 - 6.8e-06 25.6 0.0 0.061 12.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 KOO35268.1 - 3.3e-05 24.0 0.3 0.025 14.7 0.1 3.7 3 1 0 3 3 3 1 AAA domain HEAT_2 PF13646.1 KOO35268.1 - 4.7e-05 23.5 5.7 0.0033 17.6 1.0 5.2 2 1 3 5 5 5 3 HEAT repeats Miro PF08477.8 KOO35268.1 - 5.6e-05 23.6 0.0 0.066 13.7 0.0 2.5 2 0 0 2 2 2 1 Miro-like protein SbcCD_C PF13558.1 KOO35268.1 - 6.4e-05 22.8 0.0 0.053 13.4 0.0 3.2 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit NACHT PF05729.7 KOO35268.1 - 6.4e-05 22.6 0.2 0.26 10.9 0.0 3.0 3 0 0 3 3 2 2 NACHT domain AAA_28 PF13521.1 KOO35268.1 - 9.6e-05 22.3 0.4 0.013 15.4 0.0 2.8 3 0 0 3 3 2 1 AAA domain MMR_HSR1 PF01926.18 KOO35268.1 - 9.6e-05 22.3 0.0 0.016 15.1 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_17 PF13207.1 KOO35268.1 - 0.00012 22.8 0.0 0.044 14.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain Arm PF00514.18 KOO35268.1 - 0.00039 20.1 2.6 8.7 6.3 0.0 5.3 5 0 0 5 5 4 0 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 KOO35268.1 - 0.00045 20.6 21.4 0.013 16.0 0.3 6.7 7 1 1 8 8 6 2 HEAT-like repeat AAA_23 PF13476.1 KOO35268.1 - 0.00076 19.8 0.0 0.72 10.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 KOO35268.1 - 0.0012 18.4 0.5 0.76 9.1 0.0 3.3 3 0 0 3 3 3 1 AAA-like domain CLASP_N PF12348.3 KOO35268.1 - 0.0024 17.2 0.0 0.069 12.4 0.0 2.9 3 0 0 3 3 3 1 CLASP N terminal AAA_33 PF13671.1 KOO35268.1 - 0.0034 17.2 0.0 5.9 6.7 0.0 3.3 4 0 0 4 4 2 0 AAA domain RNA_helicase PF00910.17 KOO35268.1 - 0.0078 16.3 0.0 6.8 6.9 0.0 2.6 2 0 0 2 2 2 0 RNA helicase Dynamin_N PF00350.18 KOO35268.1 - 0.0083 15.9 0.1 5.1 6.8 0.0 2.4 2 0 0 2 2 2 0 Dynamin family AAA_14 PF13173.1 KOO35268.1 - 0.0085 15.9 0.0 2.2 8.1 0.0 3.2 4 0 0 4 4 2 1 AAA domain AAA_16 PF13191.1 KOO35268.1 - 0.0087 16.0 5.8 2 8.3 0.0 4.4 4 1 0 4 4 3 1 AAA ATPase domain AAA_18 PF13238.1 KOO35268.1 - 0.02 15.1 0.0 0.76 10.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 KOO35268.1 - 0.051 13.1 1.3 3.8 7.0 0.0 3.3 4 0 0 4 4 4 0 AAA domain cobW PF02492.14 KOO35268.1 - 0.054 12.9 0.1 2.5 7.5 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.24 KOO35268.1 - 0.061 13.5 0.0 3.8 7.7 0.0 2.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MMS19_C PF12460.3 KOO35268.1 - 0.067 11.9 0.0 0.91 8.1 0.0 2.3 2 0 0 2 2 2 0 RNAPII transcription regulator C-terminal ATP-synt_ab PF00006.20 KOO35268.1 - 0.072 12.5 0.1 4.8 6.6 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Septin PF00735.13 KOO35268.1 - 0.08 11.9 0.0 0.6 9.0 0.0 2.0 2 0 0 2 2 2 0 Septin PduV-EutP PF10662.4 KOO35268.1 - 0.087 12.3 0.2 0.95 8.9 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MobB PF03205.9 KOO35268.1 - 0.094 12.4 0.1 1.6 8.4 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B SRP54 PF00448.17 KOO35268.1 - 0.1 12.0 3.0 1.2 8.5 0.1 3.3 4 0 0 4 4 3 0 SRP54-type protein, GTPase domain NTPase_1 PF03266.10 KOO35268.1 - 0.14 11.8 0.1 9.9 5.8 0.0 3.1 3 0 0 3 3 3 0 NTPase Arf PF00025.16 KOO35268.1 - 0.17 11.1 0.2 8.5 5.5 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family HrpJ PF07201.6 KOO35268.1 - 2 8.3 5.1 5.3 7.0 0.2 3.4 4 0 0 4 4 3 0 HrpJ-like domain Abhydrolase_6 PF12697.2 KOO35269.1 - 1.1e-32 113.7 0.9 1.7e-32 113.1 0.6 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO35269.1 - 1.4e-19 70.3 0.0 3e-19 69.2 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO35269.1 - 7.9e-13 48.4 0.1 3.2e-05 23.6 0.0 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 KOO35269.1 - 0.00033 19.9 0.0 0.0033 16.6 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Ndr PF03096.9 KOO35269.1 - 0.0039 15.7 0.0 0.19 10.1 0.0 2.1 2 0 0 2 2 2 1 Ndr family DLH PF01738.13 KOO35269.1 - 0.022 14.0 0.0 6.6 5.9 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family UPF0227 PF05728.7 KOO35269.1 - 0.046 13.4 0.0 3.9 7.1 0.0 2.8 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0227) PGAP1 PF07819.8 KOO35269.1 - 0.19 11.2 0.0 0.59 9.6 0.0 1.7 1 1 0 1 1 1 0 PGAP1-like protein SAM_2 PF07647.12 KOO35270.1 - 3.1e-07 30.1 0.0 4.8e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 KOO35270.1 - 1.6e-06 28.1 0.0 2.6e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Glyco_transf_34 PF05637.7 KOO35272.1 - 0.085 12.3 0.1 0.16 11.4 0.1 1.4 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family FliX PF10768.4 KOO35274.1 - 0.008 16.4 2.1 0.008 16.4 1.5 2.0 2 0 0 2 2 2 1 Class II flagellar assembly regulator Nop14 PF04147.7 KOO35274.1 - 0.69 7.7 10.8 0.97 7.2 7.5 1.2 1 0 0 1 1 1 0 Nop14-like family SURF2 PF05477.6 KOO35274.1 - 0.92 8.5 4.4 38 3.2 0.0 2.2 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) Ebola_NP PF05505.7 KOO35274.1 - 2.1 6.3 5.7 3 5.7 4.0 1.1 1 0 0 1 1 1 0 Ebola nucleoprotein DUF3295 PF11702.3 KOO35274.1 - 3.9 6.3 10.1 5.8 5.7 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) SNF2_N PF00176.18 KOO35275.1 - 1.3e-37 129.1 0.0 2.3e-37 128.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.24 KOO35275.1 - 2.6e-10 40.0 0.0 4.9e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO35275.1 - 1e-08 34.9 0.0 4.8e-08 32.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO35275.1 - 0.0014 18.5 0.0 0.06 13.1 0.0 2.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Polyketide_cyc2 PF10604.4 KOO35276.1 - 0.00017 21.7 0.2 0.00017 21.7 0.1 2.7 3 0 0 3 3 3 1 Polyketide cyclase / dehydrase and lipid transport Ribosomal_L11 PF00298.14 KOO35276.1 - 0.44 10.7 4.7 0.12 12.5 0.6 2.2 2 0 0 2 2 2 0 Ribosomal protein L11, RNA binding domain HemY_N PF07219.8 KOO35276.1 - 4.2 6.9 11.2 0.16 11.5 1.9 2.4 2 0 0 2 2 2 0 HemY protein N-terminus Aldedh PF00171.17 KOO35277.1 - 8.7e-80 268.2 0.0 9.8e-80 268.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family APH PF01636.18 KOO35278.1 - 1.9e-19 70.3 0.0 2.5e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 KOO35278.1 - 4.6e-08 32.9 0.1 7.8e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.20 KOO35278.1 - 0.03 13.4 0.0 0.055 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain LRR_6 PF13516.1 KOO35279.1 - 3.1e-09 35.9 1.3 0.0024 17.7 0.0 5.3 6 0 0 6 6 6 2 Leucine Rich repeat LRR_1 PF00560.28 KOO35279.1 - 0.0006 19.4 0.1 8.6 6.8 0.0 4.5 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_4 PF12799.2 KOO35279.1 - 0.0013 18.2 0.0 6 6.5 0.0 4.1 3 1 1 5 5 5 2 Leucine Rich repeats (2 copies) BCLP PF12304.3 KOO35279.1 - 0.073 12.4 0.8 0.15 11.4 0.2 1.7 2 0 0 2 2 2 0 Beta-casein like protein LRR_7 PF13504.1 KOO35279.1 - 0.078 13.2 3.0 30 5.4 0.0 4.8 5 0 0 5 5 5 0 Leucine rich repeat LRR_5 PF13306.1 KOO35280.1 - 4.4e-101 333.6 0.0 8e-38 129.0 0.0 3.0 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO35280.1 - 8e-32 108.8 0.0 3.8e-07 29.7 0.0 6.2 1 1 5 6 6 6 6 Leucine rich repeat Fork_head_N PF08430.7 KOO35280.1 - 0.0031 17.8 4.6 4.7 7.5 1.7 3.2 1 1 1 2 2 2 2 Forkhead N-terminal region DUF1068 PF06364.7 KOO35280.1 - 0.29 10.7 12.5 0.66 9.5 0.2 4.5 1 1 3 6 6 6 0 Protein of unknown function (DUF1068) PhyH PF05721.8 KOO35281.1 - 0.0032 17.5 0.1 0.0073 16.3 0.1 1.5 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) IQ PF00612.22 KOO35281.1 - 0.009 15.5 3.8 0.037 13.6 2.7 2.2 1 0 0 1 1 1 1 IQ calmodulin-binding motif Mitoc_L55 PF09776.4 KOO35282.1 - 3.2e-05 23.4 0.1 5.2 6.6 0.0 5.4 1 1 4 6 6 6 2 Mitochondrial ribosomal protein L55 DUF4569 PF15133.1 KOO35282.1 - 0.11 11.8 2.0 3.1 7.0 0.0 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4569) RNase_T PF00929.19 KOO35283.1 - 1.1e-21 77.8 0.0 1.6e-21 77.3 0.0 1.2 1 0 0 1 1 1 1 Exonuclease RNase_H_2 PF13482.1 KOO35283.1 - 0.066 13.0 0.0 12 5.6 0.0 2.2 2 0 0 2 2 2 0 RNase_H superfamily tRNA-synt_1 PF00133.17 KOO35285.1 - 3.7e-218 725.3 0.0 4.9e-218 724.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 KOO35285.1 - 5.7e-25 87.8 0.2 1.4e-24 86.6 0.0 1.7 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 KOO35285.1 - 3.3e-18 65.5 0.0 2.8e-06 26.2 0.0 4.0 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 KOO35285.1 - 0.00062 18.9 0.0 0.0011 18.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Kelch_3 PF13415.1 KOO35286.1 - 8.7e-13 48.0 10.8 8.9e-07 28.9 0.2 5.4 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_4 PF13418.1 KOO35286.1 - 5.8e-08 32.3 8.8 2.7e-06 27.0 0.0 5.4 6 0 0 6 6 6 1 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO35286.1 - 0.00079 19.3 2.7 0.55 10.2 0.0 4.9 5 0 0 5 5 5 1 Kelch motif Kelch_6 PF13964.1 KOO35286.1 - 0.031 14.4 0.1 9.8 6.5 0.0 3.7 4 0 0 4 4 4 0 Kelch motif Kelch_2 PF07646.10 KOO35286.1 - 0.18 11.6 5.6 2.5 8.0 0.0 4.1 5 0 0 5 5 5 0 Kelch motif Pkinase PF00069.20 KOO35287.1 - 0.011 14.9 0.2 0.77 8.8 0.0 2.7 1 1 0 2 2 2 0 Protein kinase domain TFIID_30kDa PF03540.8 KOO35287.1 - 0.065 13.0 0.2 6.7 6.6 0.0 2.5 2 0 0 2 2 2 0 Transcription initiation factor TFIID 23-30kDa subunit RVT_1 PF00078.22 KOO35290.1 - 0.047 13.0 0.0 0.085 12.1 0.0 1.4 1 1 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) EF-hand_7 PF13499.1 KOO35292.1 - 8e-11 41.9 0.0 1.6e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO35292.1 - 1.2e-10 39.8 1.0 0.00016 20.7 0.2 2.8 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO35292.1 - 7.3e-10 37.8 0.4 9.9e-05 21.9 0.1 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 KOO35292.1 - 6.7e-09 35.2 0.1 0.0029 17.1 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO35292.1 - 1.3e-08 33.7 0.7 0.0068 15.7 0.3 3.3 3 0 0 3 3 3 2 EF hand Ank_4 PF13637.1 KOO35293.1 - 3.5e-06 27.3 0.0 0.00045 20.6 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.25 KOO35293.1 - 4.9e-06 26.0 0.0 0.053 13.3 0.0 3.3 3 1 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 KOO35293.1 - 0.00014 21.9 0.0 0.01 16.0 0.0 3.0 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO35293.1 - 0.00019 21.7 0.0 0.00042 20.5 0.0 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO35293.1 - 0.0022 18.0 0.0 0.29 11.4 0.0 3.5 4 0 0 4 4 4 1 Ankyrin repeat DUF1470 PF07336.6 KOO35293.1 - 0.063 13.6 1.1 0.13 12.6 0.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1470) HCV_NS5a_C PF12941.2 KOO35293.1 - 0.11 12.1 0.1 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 HCV NS5a protein C-terminal region Beta_helix PF13229.1 KOO35294.1 - 1.8e-10 40.8 13.6 4.1e-09 36.3 9.6 2.2 1 1 0 1 1 1 1 Right handed beta helix region Adeno_E1B_55K PF01696.12 KOO35294.1 - 0.21 9.9 0.3 0.31 9.4 0.2 1.1 1 0 0 1 1 1 0 Adenovirus EB1 55K protein / large t-antigen Aa_trans PF01490.13 KOO35295.1 - 4.5e-18 64.9 12.3 6.6e-18 64.3 8.5 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF4131 PF13567.1 KOO35295.1 - 0.001 18.5 1.0 0.001 18.5 0.7 2.9 3 1 0 3 3 3 1 Domain of unknown function (DUF4131) EF-hand_1 PF00036.27 KOO35296.1 - 3.4e-20 69.7 6.1 9.6e-06 24.5 0.4 4.7 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO35296.1 - 2.4e-19 69.2 1.0 7.1e-09 35.6 0.5 3.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO35296.1 - 1.9e-16 58.3 4.4 0.0017 18.0 0.1 4.8 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO35296.1 - 7.4e-12 44.0 4.8 0.00085 18.5 0.2 4.3 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO35296.1 - 1.4e-09 37.3 9.1 0.00046 19.7 1.2 4.1 3 2 2 5 5 5 2 EF-hand domain pair LRR_8 PF13855.1 KOO35296.1 - 1.1e-06 28.2 1.8 0.00017 21.2 0.3 2.8 1 1 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.2 KOO35296.1 - 1.4e-06 27.7 0.1 0.026 14.1 0.0 3.0 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO35296.1 - 9.7e-06 24.9 1.9 1.7 8.9 0.1 4.6 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_6 PF13516.1 KOO35296.1 - 5.9e-05 22.7 0.7 0.0056 16.6 0.0 3.8 4 0 0 4 4 4 1 Leucine Rich repeat LRR_7 PF13504.1 KOO35296.1 - 0.012 15.6 4.8 7.4 7.2 0.1 4.4 4 1 0 4 4 3 0 Leucine rich repeat EF-hand_4 PF12763.2 KOO35296.1 - 0.033 13.9 0.1 4.9 6.9 0.0 2.5 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO35296.1 - 0.05 13.2 6.9 3.6 7.3 0.1 3.6 4 0 0 4 4 4 0 EF hand SPARC_Ca_bdg PF10591.4 KOO35296.1 - 0.064 13.2 0.0 0.67 10.0 0.0 2.5 1 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF2009 PF09418.5 KOO35297.1 - 4.7e-33 114.6 1.3 5.1e-33 114.5 0.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) RMMBL PF07521.7 KOO35298.1 - 0.041 13.7 0.0 0.084 12.7 0.0 1.4 1 0 0 1 1 1 0 RNA-metabolising metallo-beta-lactamase TPP_enzyme_N PF02776.13 KOO35299.1 - 4.6e-56 189.0 0.0 8.9e-56 188.0 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 KOO35299.1 - 1.5e-40 138.2 0.1 4.9e-40 136.6 0.0 2.0 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 KOO35299.1 - 2.3e-39 134.2 0.1 5.3e-39 133.0 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain Bmp PF02608.9 KOO35299.1 - 0.0044 15.8 0.0 0.17 10.6 0.0 2.7 3 0 0 3 3 3 1 Basic membrane protein SNF2_N PF00176.18 KOO35301.1 - 1.9e-62 210.7 0.0 2.6e-62 210.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.19 KOO35301.1 - 1.3e-18 66.4 0.5 2.6e-09 36.6 0.0 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.26 KOO35301.1 - 1.5e-11 43.9 0.0 2.9e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO35301.1 - 1.7e-05 24.7 0.0 0.017 14.9 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.24 KOO35301.1 - 7e-05 22.3 0.0 0.00026 20.5 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.3 KOO35301.1 - 0.28 9.9 0.0 3 6.5 0.0 2.5 1 1 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 MORN PF02493.15 KOO35302.1 - 1.4e-12 46.5 32.3 0.0003 20.3 1.5 6.3 6 0 0 6 6 6 5 MORN repeat DUF4638 PF15472.1 KOO35302.1 - 0.064 12.8 6.1 0.32 10.5 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) Pox_vIL-18BP PF05566.7 KOO35302.1 - 0.15 12.0 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 Orthopoxvirus interleukin 18 binding protein SET PF00856.23 KOO35303.1 - 0.00055 20.2 0.1 0.027 14.7 0.0 2.8 2 1 0 2 2 2 1 SET domain LRR_6 PF13516.1 KOO35304.1 - 3.7e-24 82.0 23.3 0.0048 16.8 0.1 10.7 11 0 0 11 11 11 8 Leucine Rich repeat LRR_1 PF00560.28 KOO35304.1 - 7.6e-14 49.6 2.7 0.28 11.3 0.2 8.8 9 0 0 9 9 9 3 Leucine Rich Repeat LRR_4 PF12799.2 KOO35304.1 - 6.1e-09 35.3 19.4 0.058 13.0 0.0 7.2 6 3 0 6 6 6 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO35304.1 - 5.9e-08 32.3 8.7 3.2 7.5 0.5 7.3 4 1 4 8 8 8 6 Leucine rich repeat LRR_7 PF13504.1 KOO35304.1 - 3.4e-06 26.3 18.9 2.7 8.5 0.4 8.8 9 0 0 9 9 9 3 Leucine rich repeat Nucleoplasmin PF03066.10 KOO35304.1 - 0.0083 15.6 4.0 0.019 14.5 2.8 1.6 1 0 0 1 1 1 1 Nucleoplasmin DUF971 PF06155.7 KOO35304.1 - 0.069 13.5 0.0 9.9 6.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF971) PBP1_TM PF14812.1 KOO35304.1 - 0.45 10.8 6.8 0.86 9.9 4.7 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.5 KOO35304.1 - 1.1 9.4 10.9 2.4 8.4 7.6 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Agenet PF05641.7 KOO35308.1 - 5.7e-14 52.0 5.1 1.1e-09 38.3 0.8 2.5 2 0 0 2 2 2 2 Agenet domain Chromo PF00385.19 KOO35308.1 - 1.2e-07 31.2 0.3 4.3e-07 29.4 0.0 2.1 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain EF-hand_1 PF00036.27 KOO35309.1 - 6.8e-12 43.7 0.2 0.00037 19.5 0.0 4.8 5 0 0 5 5 5 3 EF hand EF-hand_5 PF13202.1 KOO35309.1 - 2.4e-07 29.7 3.1 0.065 12.6 0.0 4.5 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.1 KOO35309.1 - 2.1e-06 27.1 0.0 0.051 13.4 0.0 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.1 KOO35309.1 - 0.0021 18.1 0.0 1.7 8.8 0.0 3.6 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO35309.1 - 0.0099 15.4 0.0 2.2 7.9 0.0 3.8 3 0 0 3 3 3 1 EF-hand domain pair FAM195 PF14799.1 KOO35309.1 - 0.035 13.9 0.1 8.3 6.3 0.0 2.5 2 0 0 2 2 2 0 FAM195 family DASH_Dad2 PF08654.5 KOO35309.1 - 0.16 12.0 3.7 22 5.0 0.0 3.6 3 1 0 3 3 3 0 DASH complex subunit Dad2 EDR1 PF14381.1 KOO35310.1 - 0.084 12.4 1.8 0.42 10.1 0.1 2.5 1 1 1 2 2 2 0 Ethylene-responsive protein kinase Le-CTR1 VWA_2 PF13519.1 KOO35312.1 - 3.1e-05 24.1 0.0 6.5e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.23 KOO35312.1 - 0.0035 17.0 0.0 0.0062 16.2 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Helicase_C_2 PF13307.1 KOO35312.1 - 0.12 12.2 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 Helicase C-terminal domain Rep_fac_C PF08542.6 KOO35314.1 - 6e-20 71.0 0.1 1.5e-19 69.7 0.0 1.7 2 0 0 2 2 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 KOO35314.1 - 2.3e-08 33.8 0.0 1.1e-07 31.7 0.0 1.9 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_16 PF13191.1 KOO35314.1 - 9.4e-05 22.4 0.2 0.00077 19.4 0.1 2.3 2 1 0 2 2 2 1 AAA ATPase domain Rad17 PF03215.10 KOO35314.1 - 0.0001 21.1 0.0 0.00015 20.5 0.0 1.2 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA PF00004.24 KOO35314.1 - 0.0049 17.0 0.0 0.012 15.8 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOO35314.1 - 0.021 14.9 0.0 0.059 13.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain DNA_pol3_delta PF06144.8 KOO35314.1 - 0.034 13.6 0.0 0.061 12.8 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase III, delta subunit RuvB_N PF05496.7 KOO35314.1 - 0.046 12.7 0.1 2.5 7.0 0.0 2.6 3 0 0 3 3 3 0 Holliday junction DNA helicase ruvB N-terminus FtsK_SpoIIIE PF01580.13 KOO35314.1 - 0.048 13.1 0.0 0.13 11.7 0.0 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_5 PF07728.9 KOO35314.1 - 0.055 13.1 0.1 0.19 11.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.1 KOO35314.1 - 0.057 12.9 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_10 PF12846.2 KOO35314.1 - 0.069 12.5 0.0 0.3 10.4 0.0 2.0 1 1 0 1 1 1 0 AAA-like domain AAA_11 PF13086.1 KOO35314.1 - 0.076 12.5 0.0 0.13 11.8 0.0 1.4 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 KOO35314.1 - 0.099 12.1 0.0 11 5.4 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_33 PF13671.1 KOO35314.1 - 0.11 12.4 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain T4SS-DNA_transf PF02534.9 KOO35314.1 - 0.12 10.9 0.0 0.17 10.3 0.0 1.2 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer Linker_histone PF00538.14 KOO35314.1 - 0.14 12.3 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 linker histone H1 and H5 family ABC_tran PF00005.22 KOO35314.1 - 0.17 12.1 0.0 0.27 11.5 0.0 1.3 1 0 0 1 1 1 0 ABC transporter DUF1978 PF09321.5 KOO35315.1 - 5.1 6.4 12.3 0.17 11.2 3.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1978) Bestrophin PF01062.16 KOO35316.1 - 2.8e-20 72.4 0.4 3.8e-20 72.0 0.3 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel LRR_6 PF13516.1 KOO35317.1 - 1.1e-07 31.1 1.3 0.23 11.6 0.0 4.7 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.2 KOO35317.1 - 0.038 13.6 0.2 64 3.3 0.0 3.5 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) U-box PF04564.10 KOO35318.1 - 2.4e-11 43.4 0.0 4.6e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO35318.1 - 0.013 14.9 0.0 0.028 13.9 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit PAT1 PF09770.4 KOO35318.1 - 3.3 5.8 8.0 4.5 5.3 5.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Polysacc_deac_1 PF01522.16 KOO35319.1 - 3e-18 65.6 0.0 4.6e-18 65.0 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase TauD PF02668.11 KOO35320.1 - 0.0035 17.0 0.0 0.0069 16.0 0.0 1.5 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF4471 PF14740.1 KOO35321.1 - 0.047 12.9 0.0 0.068 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) UVR PF02151.14 KOO35321.1 - 1.3 8.6 4.5 0.68 9.5 0.2 2.5 2 0 0 2 2 2 0 UvrB/uvrC motif Gly-zipper_Omp PF13488.1 KOO35322.1 - 0.0069 16.0 5.6 0.0069 16.0 3.9 2.1 1 1 1 2 2 2 1 Glycine zipper Bacteriocin_IIc PF10439.4 KOO35322.1 - 0.042 13.9 6.2 0.091 12.9 4.3 1.6 1 1 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide DUF456 PF04306.8 KOO35322.1 - 0.051 13.6 6.6 0.11 12.5 4.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF456) gpUL132 PF11359.3 KOO35322.1 - 0.15 11.3 1.7 0.18 11.1 1.2 1.1 1 0 0 1 1 1 0 Glycoprotein UL132 Gly-zipper_OmpA PF13436.1 KOO35322.1 - 0.17 11.5 4.1 0.27 10.9 2.9 1.5 1 1 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain DUF1269 PF06897.7 KOO35322.1 - 0.36 10.8 3.1 0.65 10.0 2.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1269) FTR1 PF03239.9 KOO35322.1 - 0.5 9.2 5.1 0.079 11.8 0.9 1.5 2 0 0 2 2 2 0 Iron permease FTR1 family DUF2453 PF10507.4 KOO35322.1 - 0.74 9.6 4.7 3.1 7.6 2.9 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2453) Gly-zipper_YMGG PF13441.1 KOO35322.1 - 1 8.9 9.8 3.5 7.2 6.8 1.8 1 1 0 1 1 1 0 YMGG-like Gly-zipper Myc_target_1 PF15179.1 KOO35322.1 - 3.9 6.9 5.6 0.57 9.7 0.9 1.8 1 1 0 2 2 2 0 Myc target protein 1 DUF4137 PF13593.1 KOO35322.1 - 4.2 6.3 9.4 4.4 6.3 6.5 1.1 1 0 0 1 1 1 0 SBF-like CPA transporter family (DUF4137) Rick_17kDa_Anti PF05433.10 KOO35322.1 - 4.3 7.0 12.9 15 5.3 8.9 1.8 1 1 0 1 1 1 0 Glycine zipper 2TM domain DUF3487 PF11990.3 KOO35322.1 - 9.5 5.6 7.8 9.7 5.6 2.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) Spore_coat_CotO PF14153.1 KOO35323.1 - 0.088 12.2 5.8 0.13 11.6 4.0 1.2 1 0 0 1 1 1 0 Spore coat protein CotO eIF3_subunit PF08597.5 KOO35323.1 - 1.4 8.3 11.2 2 7.9 7.8 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit START PF01852.14 KOO35324.1 - 4.5e-18 65.3 0.0 9.8e-18 64.2 0.0 1.5 1 0 0 1 1 1 1 START domain 4HBT PF03061.17 KOO35324.1 - 2.1e-17 62.9 5.5 2.3e-08 34.0 1.0 2.8 2 0 0 2 2 2 2 Thioesterase superfamily EF-hand_4 PF12763.2 KOO35324.1 - 8.8e-10 38.2 0.0 1.8e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_8 PF13833.1 KOO35324.1 - 0.014 15.0 0.0 0.034 13.7 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair Pkinase PF00069.20 KOO35325.1 - 8.5e-51 172.5 0.0 1.1e-50 172.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO35325.1 - 1.4e-17 63.6 0.0 2.3e-17 62.9 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO35325.1 - 9.7e-10 37.8 0.0 4.8e-07 29.0 0.0 2.4 1 1 1 2 2 2 2 Kinase-like APH PF01636.18 KOO35325.1 - 6.4e-06 26.0 0.1 8.5e-05 22.3 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 KOO35325.1 - 0.0022 17.3 0.0 0.0036 16.6 0.0 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Pox_ser-thr_kin PF05445.6 KOO35325.1 - 0.0085 14.9 0.0 0.012 14.4 0.0 1.1 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase Choline_kinase PF01633.15 KOO35325.1 - 0.01 15.4 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.9 KOO35325.1 - 0.016 14.2 0.0 0.027 13.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FAD_binding_3 PF01494.14 KOO35326.1 - 2.5e-06 26.8 0.4 4.8e-06 25.8 0.3 1.5 1 0 0 1 1 1 1 FAD binding domain EF-hand_5 PF13202.1 KOO35326.1 - 0.012 14.8 0.0 0.025 13.9 0.0 1.5 1 0 0 1 1 1 0 EF hand GLE1 PF07817.8 KOO35327.1 - 1e-31 109.7 0.0 1.3e-31 109.5 0.0 1.1 1 0 0 1 1 1 1 GLE1-like protein DUF3342 PF11822.3 KOO35330.1 - 1e-40 139.8 0.0 1.3e-40 139.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) BTB PF00651.26 KOO35330.1 - 0.00026 20.9 0.0 0.00045 20.1 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain EF-hand_1 PF00036.27 KOO35331.1 - 3.5e-19 66.5 8.8 6e-06 25.1 0.1 4.0 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.1 KOO35331.1 - 2.4e-18 64.5 6.3 8.3e-07 28.0 0.2 3.9 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.1 KOO35331.1 - 5.4e-18 64.8 0.0 8.9e-12 44.9 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO35331.1 - 4.3e-16 58.2 8.2 6.2e-10 38.5 0.6 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO35331.1 - 8.9e-16 56.2 4.9 5e-06 25.9 0.1 4.2 5 0 0 5 5 5 3 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO35331.1 - 1.7e-06 28.0 4.3 1e-05 25.5 0.0 2.9 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO35331.1 - 0.0027 17.4 0.8 0.059 13.1 0.2 2.6 2 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand PAN_1 PF00024.21 KOO35331.1 - 0.0096 15.6 2.4 0.017 14.8 1.6 1.3 1 0 0 1 1 1 1 PAN domain TTL PF03133.10 KOO35333.1 - 2.1e-31 108.9 0.0 2.6e-31 108.6 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATP-grasp_4 PF13535.1 KOO35333.1 - 0.0012 18.6 0.0 0.034 13.8 0.0 2.2 2 0 0 2 2 2 1 ATP-grasp domain ATPgrasp_YheCD PF14398.1 KOO35333.1 - 0.017 13.9 0.0 3 6.5 0.0 2.8 2 1 0 2 2 2 0 YheC/D like ATP-grasp CP_ATPgrasp_1 PF04174.8 KOO35333.1 - 0.051 12.1 0.0 0.17 10.4 0.0 1.7 2 0 0 2 2 2 0 A circularly permuted ATPgrasp Dala_Dala_lig_C PF07478.8 KOO35333.1 - 0.17 11.2 0.0 0.41 9.9 0.0 1.5 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus Toxin_14 PF07829.6 KOO35334.1 - 0.39 10.4 7.8 0.066 12.9 2.3 2.1 2 0 0 2 2 2 0 Alpha-A conotoxin PIVA-like protein LRR_5 PF13306.1 KOO35335.1 - 1.3e-103 341.8 2.5 1.6e-39 134.5 0.0 3.1 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO35335.1 - 2.2e-24 84.9 0.0 0.00031 20.4 0.0 6.1 1 1 5 6 6 6 5 Leucine rich repeat EF-hand_7 PF13499.1 KOO35337.1 - 2.8e-18 65.8 0.1 2.8e-08 33.7 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO35337.1 - 1.2e-16 59.0 1.0 0.0003 20.4 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.27 KOO35337.1 - 8.5e-16 55.9 0.1 4.3e-05 22.5 0.0 4.5 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.1 KOO35337.1 - 3e-13 48.4 0.2 0.0008 18.6 0.0 4.5 4 0 0 4 4 4 2 EF hand GPS PF01825.16 KOO35337.1 - 4.7e-12 45.8 5.7 8.7e-12 44.9 4.0 1.4 1 0 0 1 1 1 1 Latrophilin/CL-1-like GPS domain EF-hand_8 PF13833.1 KOO35337.1 - 1.5e-05 24.5 0.1 0.14 11.8 0.0 3.4 2 2 2 4 4 4 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO35337.1 - 0.017 15.1 0.0 0.3 11.1 0.0 2.3 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region SAP PF02037.22 KOO35337.1 - 0.65 9.5 2.1 31 4.2 0.0 2.7 3 0 0 3 3 3 0 SAP domain Antimicrobial13 PF08108.6 KOO35337.1 - 5.9 6.9 9.4 20 5.2 1.0 2.9 2 0 0 2 2 2 0 Halocidin family LRR_4 PF12799.2 KOO35338.1 - 5.3e-21 73.7 33.8 2.1e-05 24.0 0.3 9.8 6 2 3 10 10 10 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO35338.1 - 6.4e-11 41.8 36.8 1.8e-05 24.4 0.1 8.9 5 3 5 10 10 10 5 Leucine rich repeat LRR_1 PF00560.28 KOO35338.1 - 1.1e-08 33.9 25.7 22 5.5 0.0 13.1 13 0 0 13 13 13 0 Leucine Rich Repeat LRR_6 PF13516.1 KOO35338.1 - 3.9e-06 26.3 44.4 0.1 12.7 0.3 11.8 12 0 0 12 12 12 4 Leucine Rich repeat Miro PF08477.8 KOO35338.1 - 9.6e-05 22.8 0.0 0.00027 21.4 0.0 1.9 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO35338.1 - 0.00025 20.3 0.0 0.00056 19.1 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 KOO35338.1 - 0.001 18.4 0.0 0.0031 16.9 0.0 1.8 2 0 0 2 2 2 1 Ras family LRR_7 PF13504.1 KOO35338.1 - 0.074 13.2 31.4 13 6.5 0.2 12.4 13 1 0 13 13 13 0 Leucine rich repeat G-alpha PF00503.15 KOO35338.1 - 0.68 8.5 0.0 1.6 7.3 0.0 1.5 1 0 0 1 1 1 0 G-protein alpha subunit NifU PF01106.12 KOO35339.1 - 1.4e-29 101.6 0.2 5.9e-23 80.4 0.1 2.4 2 0 0 2 2 2 2 NifU-like domain Aldo_ket_red PF00248.16 KOO35341.1 - 3.9e-44 150.5 0.0 6e-44 149.9 0.0 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family Prp19_bind PF06991.6 KOO35342.1 - 1e-60 205.3 15.1 1e-60 205.3 10.5 3.1 2 1 1 3 3 3 2 Splicing factor, Prp19-binding domain DUF883 PF05957.8 KOO35344.1 - 0.014 15.7 7.4 0.014 15.7 5.1 7.7 2 2 7 9 9 9 0 Bacterial protein of unknown function (DUF883) Latarcin PF10279.4 KOO35345.1 - 0.014 15.5 0.2 0.029 14.5 0.1 1.6 1 0 0 1 1 1 0 Latarcin precursor Hypoth_Ymh PF09509.5 KOO35345.1 - 0.026 14.1 0.6 0.9 9.1 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (Hypoth_ymh) DUF3322 PF11795.3 KOO35345.1 - 0.044 13.4 1.1 0.067 12.8 0.8 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) MutS_III PF05192.13 KOO35345.1 - 0.067 12.9 0.4 0.099 12.4 0.3 1.3 1 0 0 1 1 1 0 MutS domain III DXP_reductoisom PF02670.11 KOO35345.1 - 0.11 12.9 0.3 0.23 12.0 0.2 1.4 1 1 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase PhyH PF05721.8 KOO35346.1 - 1.2e-13 51.6 0.0 1.3e-07 31.8 0.0 3.0 2 2 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) CRAL_TRIO PF00650.15 KOO35347.1 - 3.6e-16 59.0 0.0 4.1e-16 58.8 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain EF-hand_1 PF00036.27 KOO35348.1 - 3.2e-39 129.2 11.3 3.3e-06 25.9 0.1 6.5 6 0 0 6 6 6 6 EF hand EF-hand_5 PF13202.1 KOO35348.1 - 2e-33 112.2 6.3 0.00033 19.8 0.0 6.6 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.1 KOO35348.1 - 9.8e-33 112.1 5.9 1e-10 41.5 0.4 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO35348.1 - 1.8e-30 102.0 0.2 0.0006 19.4 0.0 6.5 6 0 0 6 6 6 6 EF-hand domain EF-hand_8 PF13833.1 KOO35348.1 - 5.7e-20 70.6 12.4 6.8e-06 25.6 0.1 6.1 4 2 2 6 6 6 6 EF-hand domain pair EF-hand_9 PF14658.1 KOO35348.1 - 3.6e-12 46.0 0.4 0.00041 20.2 0.0 3.3 3 0 0 3 3 3 3 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO35348.1 - 3.6e-09 36.6 0.0 0.06 13.3 0.0 3.2 3 0 0 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO35348.1 - 1.5e-08 34.3 2.8 0.031 13.9 0.0 3.9 3 2 1 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO35348.1 - 0.00065 19.3 0.5 13 5.4 0.0 5.3 6 0 0 6 6 6 0 EF hand SelB-wing_3 PF09107.6 KOO35348.1 - 0.0025 17.1 0.8 37 3.8 0.0 4.5 4 0 0 4 4 4 0 Elongation factor SelB, winged helix HpaB_N PF11794.3 KOO35348.1 - 0.072 12.4 1.4 0.16 11.3 0.1 2.1 1 1 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase N terminal VCBS PF13517.1 KOO35348.1 - 0.97 9.8 4.4 40 4.6 0.0 3.8 5 0 0 5 5 5 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella CEP19 PF14933.1 KOO35348.1 - 2.4 8.4 4.2 55 4.0 0.3 3.0 3 0 0 3 3 3 0 CEP19-like protein Ank_2 PF12796.2 KOO35349.1 - 3.5e-33 113.7 2.9 4.6e-18 65.3 0.3 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO35349.1 - 3.2e-29 99.2 1.5 2e-08 33.5 0.0 4.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.1 KOO35349.1 - 1.5e-20 71.1 0.7 4.3e-06 26.4 0.0 5.5 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.1 KOO35349.1 - 5.4e-20 70.9 5.2 1.2e-08 34.9 0.1 4.4 2 2 3 5 5 5 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO35349.1 - 8.2e-20 70.7 2.8 4.1e-07 30.3 0.1 4.1 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Shigella_OspC PF06128.6 KOO35349.1 - 0.18 11.2 0.0 0.49 9.8 0.0 1.7 1 1 1 2 2 2 0 Shigella flexneri OspC protein EF-hand_7 PF13499.1 KOO35350.1 - 3.6e-29 100.7 1.5 3.4e-09 36.6 0.1 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO35350.1 - 3.5e-27 91.5 19.8 1.6e-05 23.8 0.1 6.4 6 0 0 6 6 6 6 EF hand EF-hand_5 PF13202.1 KOO35350.1 - 3.7e-24 82.9 13.4 8.8e-05 21.6 0.0 6.4 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.1 KOO35350.1 - 7.5e-23 78.3 8.0 0.0063 16.3 0.0 6.3 6 0 0 6 6 6 6 EF-hand domain EF-hand_8 PF13833.1 KOO35350.1 - 5.2e-21 74.0 18.0 3.9e-06 26.3 0.1 6.1 4 2 2 6 6 6 5 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO35350.1 - 4.1e-06 26.7 0.0 0.68 9.9 0.0 3.8 3 1 0 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOO35350.1 - 3.3e-05 23.6 0.2 0.0065 16.3 0.0 3.0 3 0 0 3 3 3 1 EF-hand domain HJURP_C PF12347.3 KOO35350.1 - 0.052 13.1 0.1 0.42 10.2 0.0 2.2 2 0 0 2 2 2 0 Holliday junction regulator protein family C-terminal repeat SHOCT PF09851.4 KOO35350.1 - 0.66 9.5 6.6 0.8 9.2 1.0 2.8 3 0 0 3 3 3 0 Short C-terminal domain Arf PF00025.16 KOO35351.1 - 3.4e-54 182.7 0.0 3.8e-54 182.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 KOO35351.1 - 9.2e-12 44.6 0.0 1e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 KOO35351.1 - 2.4e-11 42.9 1.1 5.2e-08 31.9 0.1 2.5 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.5 KOO35351.1 - 1.1e-09 37.7 0.0 1.5e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 KOO35351.1 - 1.7e-07 31.1 0.0 2.5e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 KOO35351.1 - 2.1e-05 25.0 0.0 2.9e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 KOO35351.1 - 2.8e-05 23.6 0.0 0.0013 18.2 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 KOO35351.1 - 7.6e-05 21.9 0.0 9.6e-05 21.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region 6PF2K PF01591.13 KOO35351.1 - 0.015 14.3 0.0 0.022 13.8 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase MobB PF03205.9 KOO35351.1 - 0.041 13.5 0.1 0.066 12.9 0.1 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 KOO35351.1 - 0.078 13.2 0.0 0.14 12.4 0.0 1.4 1 1 0 1 1 1 0 AAA domain RRM_1 PF00076.17 KOO35352.1 - 1.4e-13 50.2 0.0 2.3e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO35352.1 - 1.5e-08 34.4 0.0 2.7e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO35352.1 - 1.3e-05 24.9 0.0 2.3e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MatE PF01554.13 KOO35353.1 - 0.00036 20.2 6.2 0.00036 20.2 4.3 2.2 3 0 0 3 3 3 1 MatE Neurensin PF14927.1 KOO35353.1 - 0.26 10.6 2.1 0.26 10.6 0.3 1.9 1 1 0 1 1 1 0 Neurensin Patatin PF01734.17 KOO35354.1 - 1.2e-12 48.2 1.2 3.4e-12 46.7 0.8 1.8 1 1 0 1 1 1 1 Patatin-like phospholipase Pkinase PF00069.20 KOO35355.1 - 3.1e-47 160.9 0.0 4.3e-47 160.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO35355.1 - 7.9e-22 77.5 1.0 9.3e-22 77.3 0.2 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.18 KOO35355.1 - 0.0006 19.6 0.0 0.0006 19.6 0.0 2.2 3 0 0 3 3 3 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 KOO35355.1 - 0.078 11.7 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Tetraspannin PF00335.15 KOO35356.1 - 1.1e-11 44.4 6.5 1.1e-11 44.4 4.5 2.9 2 1 1 3 3 3 2 Tetraspanin family DnaJ PF00226.26 KOO35356.1 - 4e-11 42.4 0.0 1.2e-10 40.9 0.0 1.7 2 0 0 2 2 2 1 DnaJ domain Dynamin_N PF00350.18 KOO35358.1 - 8.9e-13 48.4 0.0 2.4e-06 27.4 0.0 2.3 2 0 0 2 2 2 2 Dynamin family MMR_HSR1 PF01926.18 KOO35358.1 - 3.6e-06 26.9 0.0 1.4e-05 25.0 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF1273 PF06908.6 KOO35358.1 - 0.0035 17.0 0.0 0.0056 16.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1273) Miro PF08477.8 KOO35358.1 - 0.03 14.8 0.0 0.62 10.5 0.0 2.4 2 0 0 2 2 2 0 Miro-like protein AIG1 PF04548.11 KOO35358.1 - 0.047 12.8 0.0 0.58 9.2 0.0 2.2 2 0 0 2 2 2 0 AIG1 family DUF815 PF05673.8 KOO35358.1 - 0.11 11.4 0.0 0.18 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) SDH_sah PF01972.11 KOO35358.1 - 0.29 9.8 0.8 0.46 9.2 0.5 1.2 1 0 0 1 1 1 0 Serine dehydrogenase proteinase AAA PF00004.24 KOO35359.1 - 1.2e-09 38.4 0.0 2.9e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOO35359.1 - 0.0072 16.4 0.0 0.07 13.2 0.0 2.4 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.10 KOO35359.1 - 0.015 13.9 0.0 1.5 7.4 0.0 2.2 2 0 0 2 2 2 0 Rad17 cell cycle checkpoint protein Drc1-Sld2 PF11719.3 KOO35359.1 - 0.67 8.9 2.5 1 8.3 1.7 1.2 1 0 0 1 1 1 0 DNA replication and checkpoint protein DUF3611 PF12263.3 KOO35360.1 - 0.1 12.0 0.2 0.14 11.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) NAD_binding_8 PF13450.1 KOO35361.1 - 1.8e-13 50.2 0.0 6.7e-13 48.4 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOO35361.1 - 1.5e-05 24.0 0.1 3.9e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.12 KOO35361.1 - 0.0012 17.9 0.1 0.0025 16.9 0.1 1.4 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.19 KOO35361.1 - 0.0024 16.7 0.1 0.0039 16.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 KOO35361.1 - 0.0027 17.6 0.0 0.032 14.0 0.0 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 KOO35361.1 - 0.003 17.3 0.1 0.18 11.5 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.14 KOO35361.1 - 0.0063 15.6 0.1 0.011 14.8 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.22 KOO35361.1 - 0.021 15.2 0.2 0.053 13.9 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pertus-S5-tox PF09276.5 KOO35361.1 - 0.08 12.9 0.1 0.2 11.6 0.1 1.7 1 0 0 1 1 1 0 Pertussis toxin S5 subunit HI0933_like PF03486.9 KOO35361.1 - 0.21 9.9 0.1 0.32 9.3 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein RCC1 PF00415.13 KOO35362.1 - 7.3e-157 509.5 30.0 4.5e-15 55.5 0.4 14.5 14 0 0 14 14 14 13 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO35362.1 - 1.9e-76 250.3 71.7 1.9e-08 33.6 0.0 13.6 13 0 0 13 13 13 13 Regulator of chromosome condensation (RCC1) repeat RasGAP PF00616.14 KOO35362.1 - 5.2e-33 114.3 0.1 1.2e-32 113.1 0.0 1.6 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase DUF3133 PF11331.3 KOO35362.1 - 0.063 12.8 0.1 0.63 9.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3133) CBM_X PF06204.6 KOO35362.1 - 1.1 8.8 9.9 96 2.5 0.0 6.0 7 0 0 7 7 7 0 Putative carbohydrate binding domain DNA_pol_A_exo1 PF01612.15 KOO35363.1 - 3.5e-06 26.6 0.0 0.00011 21.7 0.0 2.3 1 1 1 2 2 2 2 3'-5' exonuclease Ank_2 PF12796.2 KOO35364.1 - 4.9e-23 81.2 9.6 6.9e-11 42.3 0.6 3.3 2 1 0 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO35364.1 - 3.9e-18 64.2 6.0 2.9e-05 23.6 0.0 4.6 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.1 KOO35364.1 - 1.3e-16 60.5 1.4 1.6e-08 34.8 0.1 3.6 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO35364.1 - 6.1e-16 58.0 9.8 1.1e-07 31.8 0.2 5.3 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO35364.1 - 5.1e-14 50.9 2.4 0.0032 17.5 0.0 5.1 5 0 0 5 5 5 4 Ankyrin repeat DUF1843 PF08898.5 KOO35364.1 - 0.034 14.1 11.1 0.037 14.0 0.1 4.0 3 1 0 3 3 3 0 Domain of unknown function (DUF1843) Glyco_transf_5 PF08323.6 KOO35365.1 - 9.6e-22 77.6 0.0 1.7e-21 76.8 0.0 1.3 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.15 KOO35365.1 - 2.2e-13 49.9 0.0 1.1e-12 47.7 0.0 2.1 1 1 0 1 1 1 1 Glycosyl transferases group 1 Galactosyl_T PF01762.16 KOO35365.1 - 1.8e-06 27.6 0.0 4.1e-06 26.5 0.0 1.5 2 0 0 2 2 2 1 Galactosyltransferase Glyco_trans_1_4 PF13692.1 KOO35365.1 - 7.9e-06 26.0 0.1 8.5e-05 22.7 0.0 2.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 LTP_2 PF14368.1 KOO35366.1 - 2.6 8.2 9.1 0.55 10.3 2.1 2.1 1 1 1 2 2 2 0 Probable lipid transfer Redoxin PF08534.5 KOO35367.1 - 9.2e-10 38.2 0.0 1.1e-09 37.9 0.0 1.0 1 0 0 1 1 1 1 Redoxin Aminotran_3 PF00202.16 KOO35368.1 - 1.8e-70 237.4 0.0 3.2e-70 236.6 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-III Paralemmin PF03285.10 KOO35368.1 - 2 7.8 8.3 0.21 11.0 2.7 1.5 2 0 0 2 2 2 0 Paralemmin DUF2458 PF10454.4 KOO35368.1 - 7.4 6.4 9.2 0.16 11.8 0.7 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2458) LRR_6 PF13516.1 KOO35369.1 - 1.6e-19 67.7 30.5 0.26 11.4 0.1 14.5 15 0 0 15 15 15 3 Leucine Rich repeat Ank_2 PF12796.2 KOO35369.1 - 1.8e-14 53.8 6.9 1.4e-06 28.4 1.1 3.9 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) LRR_1 PF00560.28 KOO35369.1 - 1.5e-12 45.6 6.7 7.4 7.0 0.0 11.4 13 0 0 13 13 12 1 Leucine Rich Repeat Ank_3 PF13606.1 KOO35369.1 - 3.3e-10 39.1 4.5 0.033 14.4 0.1 5.7 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.25 KOO35369.1 - 6.1e-08 32.0 9.1 0.0033 17.1 0.3 5.0 4 1 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.1 KOO35369.1 - 1.5e-07 31.7 1.0 0.007 16.8 0.0 4.5 4 1 0 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO35369.1 - 5.4e-07 29.6 8.7 0.05 13.8 0.3 5.5 4 1 2 6 6 6 3 Ankyrin repeats (many copies) LRR_8 PF13855.1 KOO35369.1 - 3.8e-05 23.3 10.2 3 7.6 0.0 7.9 7 2 2 9 9 8 3 Leucine rich repeat LRR_4 PF12799.2 KOO35369.1 - 8.5e-05 22.0 18.7 3.6 7.3 0.0 8.6 7 2 3 10 10 10 3 Leucine Rich repeats (2 copies) SPRY PF00622.23 KOO35369.1 - 0.00011 22.2 0.1 0.00029 20.9 0.0 1.8 1 0 0 1 1 1 1 SPRY domain GlutR_N PF05201.10 KOO35369.1 - 0.0081 15.7 0.6 2.4 7.7 0.0 4.1 4 1 0 4 4 4 1 Glutamyl-tRNAGlu reductase, N-terminal domain DUF971 PF06155.7 KOO35369.1 - 0.039 14.3 0.0 12 6.3 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF971) LRR_7 PF13504.1 KOO35369.1 - 0.11 12.8 25.2 18 6.1 0.2 9.7 11 0 0 11 11 10 0 Leucine rich repeat E1-E2_ATPase PF00122.15 KOO35371.1 - 1.4e-44 151.8 2.8 1.4e-44 151.8 2.0 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 KOO35371.1 - 1.1e-40 139.1 3.3 4e-40 137.2 2.3 2.0 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 KOO35371.1 - 7.6e-26 91.8 0.0 7e-25 88.7 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 KOO35371.1 - 1e-11 45.3 0.1 2.5e-11 44.0 0.1 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOO35371.1 - 4.4e-10 39.3 0.0 1.2e-09 38.0 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 KOO35371.1 - 0.00056 19.5 1.0 0.0028 17.2 0.2 2.5 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase DUF2852 PF11014.3 KOO35371.1 - 0.17 11.8 0.5 3.7 7.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2852) NnrU PF07298.6 KOO35372.1 - 1.5e-29 102.7 12.7 1.9e-29 102.3 8.8 1.1 1 0 0 1 1 1 1 NnrU protein PEMT PF04191.8 KOO35372.1 - 0.005 16.9 0.3 0.015 15.3 0.2 1.9 1 0 0 1 1 1 1 Phospholipid methyltransferase ICMT PF04140.9 KOO35372.1 - 0.0064 16.6 0.4 0.013 15.6 0.3 1.5 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family NAD_Gly3P_dh_C PF07479.9 KOO35373.1 - 0.063 12.9 0.0 0.066 12.9 0.0 1.1 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus PARG_cat PF05028.9 KOO35374.1 - 1.7e-65 221.5 0.0 3.5e-64 217.1 0.0 2.0 1 1 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) AKAP_110 PF05716.8 KOO35374.1 - 0.11 10.4 0.0 0.16 9.8 0.0 1.1 1 0 0 1 1 1 0 A-kinase anchor protein 110 kDa (AKAP 110) DUF2735 PF10931.3 KOO35374.1 - 0.38 11.0 3.2 0.43 10.8 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2735) Dynamin_N PF00350.18 KOO35375.1 - 1.2e-13 51.1 0.0 1.9e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 Dynamin family Miro PF08477.8 KOO35375.1 - 0.00074 20.0 0.0 0.0012 19.2 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein AAA_28 PF13521.1 KOO35375.1 - 0.094 12.6 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 KOO35375.1 - 0.094 12.6 1.5 0.73 9.7 0.1 2.3 2 1 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.1 KOO35375.1 - 0.12 11.9 0.1 0.27 10.7 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Dynamin_N PF00350.18 KOO35376.1 - 2.7e-07 30.5 0.0 7.1e-07 29.1 0.0 1.7 2 0 0 2 2 2 1 Dynamin family GED PF02212.13 KOO35376.1 - 0.057 13.3 0.4 0.13 12.2 0.3 1.6 1 0 0 1 1 1 0 Dynamin GTPase effector domain Arm PF00514.18 KOO35377.1 - 2.1e-13 49.5 10.1 0.00043 20.0 0.1 4.7 5 0 0 5 5 5 3 Armadillo/beta-catenin-like repeat HEAT PF02985.17 KOO35377.1 - 5.7e-06 25.9 5.5 0.066 13.3 0.1 4.9 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.1 KOO35377.1 - 1.9e-05 24.8 6.2 0.00061 20.0 0.6 3.2 2 1 1 4 4 4 2 HEAT repeats HEAT_EZ PF13513.1 KOO35377.1 - 0.15 12.5 4.2 12 6.5 0.1 4.8 4 1 1 5 5 5 0 HEAT-like repeat PIH1 PF08190.7 KOO35378.1 - 5.4e-08 32.6 0.2 5.4e-08 32.6 0.1 1.8 2 0 0 2 2 2 1 pre-RNA processing PIH1/Nop17 TPR_11 PF13414.1 KOO35378.1 - 1.8e-06 27.4 7.6 3.8e-06 26.4 1.7 2.5 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 KOO35378.1 - 0.019 14.8 6.6 0.34 10.9 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOO35378.1 - 0.071 12.7 0.4 0.35 10.5 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4304 PF14137.1 KOO35378.1 - 0.087 12.9 0.1 0.29 11.2 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4304) TPR_10 PF13374.1 KOO35380.1 - 1e-93 304.8 28.6 2.5e-13 49.4 0.2 9.0 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_12 PF13424.1 KOO35380.1 - 3.2e-78 257.6 6.1 2e-20 72.4 0.2 4.7 3 1 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.23 KOO35380.1 - 2.5e-37 124.9 3.8 0.00019 20.8 0.0 8.5 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_2 PF07719.12 KOO35380.1 - 4.1e-28 95.0 6.4 0.015 15.1 0.0 9.0 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_7 PF13176.1 KOO35380.1 - 2.9e-24 82.8 12.4 0.002 17.8 0.1 8.7 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_11 PF13414.1 KOO35380.1 - 6.5e-24 83.3 3.4 4.8e-06 26.1 0.1 5.8 2 2 4 6 6 6 5 TPR repeat TPR_17 PF13431.1 KOO35380.1 - 4.1e-22 76.4 0.1 1 9.7 0.0 8.7 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_16 PF13432.1 KOO35380.1 - 2.8e-21 75.6 38.0 5.5e-06 26.9 0.3 6.6 2 1 7 9 9 9 8 Tetratricopeptide repeat TPR_4 PF07721.9 KOO35380.1 - 3.6e-20 70.2 15.3 0.059 13.8 0.0 10.6 10 0 0 10 10 8 6 Tetratricopeptide repeat TPR_8 PF13181.1 KOO35380.1 - 4e-19 66.9 0.7 0.046 13.5 0.0 8.3 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_19 PF14559.1 KOO35380.1 - 5.1e-13 49.1 16.2 0.0077 16.5 1.1 5.0 4 1 0 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.1 KOO35380.1 - 5.6e-09 35.8 39.7 0.23 12.2 0.0 9.9 8 3 3 11 11 9 5 Tetratricopeptide repeat HisKA_3 PF07730.8 KOO35380.1 - 3.9e-06 27.1 15.9 2.4 8.5 0.0 7.3 7 0 0 7 7 7 1 Histidine kinase Rab5-bind PF09311.6 KOO35380.1 - 1.7e-05 24.8 0.2 3.9 7.3 0.0 4.3 1 1 3 5 5 5 1 Rabaptin-like protein TPR_3 PF07720.7 KOO35380.1 - 0.00034 20.3 0.0 62 3.5 0.0 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat ApoLp-III PF07464.6 KOO35380.1 - 0.00042 20.3 3.2 5.7 6.9 0.0 5.3 3 2 3 6 6 6 1 Apolipophorin-III precursor (apoLp-III) Osmo_CC PF08946.5 KOO35380.1 - 0.0013 18.7 4.9 93 3.1 0.0 6.7 7 0 0 7 7 7 0 Osmosensory transporter coiled coil TPR_6 PF13174.1 KOO35380.1 - 0.048 14.1 5.5 3e+02 2.2 0.0 7.1 8 0 0 8 8 8 0 Tetratricopeptide repeat PPR_1 PF12854.2 KOO35380.1 - 0.08 12.4 5.6 48 3.5 0.0 5.9 7 0 0 7 7 7 0 PPR repeat DUF4404 PF14357.1 KOO35380.1 - 0.19 12.1 5.5 17 5.9 0.1 4.3 3 1 2 5 5 5 0 Domain of unknown function (DUF4404) DUF3368 PF11848.3 KOO35380.1 - 5.7 6.5 14.9 4 7.0 0.1 5.5 7 0 0 7 7 7 0 Domain of unknown function (DUF3368) Ank_2 PF12796.2 KOO35384.1 - 1.6e-21 76.3 4.8 1.3e-11 44.6 0.5 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO35384.1 - 1.1e-19 69.1 7.8 2.2e-05 24.0 0.3 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.1 KOO35384.1 - 5.3e-17 61.8 2.9 2.5e-07 31.0 0.4 3.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO35384.1 - 6.3e-16 58.0 8.3 4.3e-08 33.1 0.2 3.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO35384.1 - 1e-11 43.8 3.3 0.0011 19.0 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat TIR_2 PF13676.1 KOO35384.1 - 2.2e-05 24.5 0.0 6.8e-05 22.9 0.0 1.8 1 0 0 1 1 1 1 TIR domain Ish1 PF10281.4 KOO35384.1 - 0.0079 16.2 0.0 0.021 14.9 0.0 1.7 1 0 0 1 1 1 1 Putative stress-responsive nuclear envelope protein FAD_binding_5 PF00941.16 KOO35384.1 - 0.066 12.6 2.2 0.26 10.7 0.1 2.3 1 1 0 2 2 2 0 FAD binding domain in molybdopterin dehydrogenase Arm PF00514.18 KOO35385.1 - 3.4e-22 77.4 12.6 1.2e-05 24.9 0.3 5.0 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO35385.1 - 7.3e-05 22.9 15.6 0.027 14.7 1.0 2.4 2 1 0 2 2 2 2 HEAT repeats TPR_11 PF13414.1 KOO35386.1 - 6.5e-09 35.3 3.6 8e-07 28.6 2.0 2.5 1 1 1 2 2 2 2 TPR repeat Toxin_19 PF08088.7 KOO35386.1 - 0.026 14.4 2.1 0.057 13.3 1.5 1.5 1 0 0 1 1 1 0 Conotoxin I-superfamily TPR_2 PF07719.12 KOO35386.1 - 0.038 13.9 6.7 0.26 11.2 3.4 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO35386.1 - 0.27 11.1 5.0 0.53 10.2 1.4 2.4 2 1 1 3 3 3 0 Tetratricopeptide repeat LRR_1 PF00560.28 KOO35388.1 - 0.0037 17.0 0.0 0.77 10.0 0.0 3.5 3 0 0 3 3 3 1 Leucine Rich Repeat LRR_6 PF13516.1 KOO35388.1 - 0.01 15.7 1.4 1.2 9.4 0.0 3.0 3 0 0 3 3 3 0 Leucine Rich repeat LRR_7 PF13504.1 KOO35388.1 - 0.02 15.0 1.1 7.5 7.2 0.0 4.0 3 1 0 3 3 3 0 Leucine rich repeat LRR_4 PF12799.2 KOO35388.1 - 0.024 14.2 0.0 0.1 12.2 0.1 2.0 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO35388.1 - 0.08 12.7 0.1 0.37 10.5 0.1 2.2 1 1 1 2 2 2 0 Leucine rich repeat Nuc_sug_transp PF04142.10 KOO35389.1 - 7e-51 172.6 3.3 2.2e-35 121.9 0.0 2.5 3 0 0 3 3 3 2 Nucleotide-sugar transporter TPT PF03151.11 KOO35389.1 - 4.7e-10 39.3 10.6 9e-07 28.6 7.5 3.3 2 1 1 3 3 3 1 Triose-phosphate Transporter family UAA PF08449.6 KOO35389.1 - 8.2e-06 24.9 3.3 5.4e-05 22.2 2.8 2.0 2 0 0 2 2 2 1 UAA transporter family EmrE PF13536.1 KOO35389.1 - 8.5e-06 25.9 7.1 8.5e-06 25.9 5.0 3.8 3 2 1 4 4 4 1 Multidrug resistance efflux transporter EamA PF00892.15 KOO35389.1 - 6.9e-05 22.8 8.8 6.9e-05 22.8 6.1 3.2 3 1 0 3 3 3 1 EamA-like transporter family PhyH PF05721.8 KOO35390.1 - 5.1e-07 29.9 0.1 9.1e-07 29.1 0.0 1.5 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) PT-VENN PF04829.8 KOO35391.1 - 0.24 10.9 3.3 0.55 9.8 2.3 1.6 1 0 0 1 1 1 0 Pre-toxin domain with VENN motif Glyco_transf_8 PF01501.15 KOO35392.1 - 1e-13 51.2 0.0 1.2e-13 51.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl transferase family 8 Fip1 PF05182.8 KOO35393.1 - 5e-20 70.5 0.6 7.8e-20 69.8 0.4 1.2 1 0 0 1 1 1 1 Fip1 motif Dev_Cell_Death PF10539.4 KOO35394.1 - 8e-30 103.0 0.0 1.3e-29 102.3 0.0 1.3 1 1 0 1 1 1 1 Development and cell death domain DUF4333 PF14230.1 KOO35395.1 - 0.012 15.6 0.4 0.029 14.3 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4333) ATP-synt PF00231.14 KOO35396.1 - 4.6e-74 249.3 0.2 5.4e-74 249.1 0.1 1.0 1 0 0 1 1 1 1 ATP synthase Adaptin_N PF01602.15 KOO35398.1 - 0.0084 14.4 1.6 0.01 14.1 0.2 1.8 2 1 0 2 2 2 1 Adaptin N terminal region MutS_III PF05192.13 KOO35398.1 - 0.026 14.2 5.2 0.032 14.0 3.6 1.2 1 0 0 1 1 1 0 MutS domain III Arm PF00514.18 KOO35398.1 - 0.28 11.0 15.4 3.8 7.4 0.0 5.3 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat HEAT PF02985.17 KOO35398.1 - 1.9 8.7 7.2 1.5 9.1 0.1 3.9 4 0 0 4 4 4 0 HEAT repeat PC-Esterase PF13839.1 KOO35399.1 - 0.038 13.7 0.0 0.09 12.5 0.0 1.7 1 1 0 1 1 1 0 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p Laminin_G_3 PF13385.1 KOO35400.1 - 7e-26 91.3 0.1 1.1e-25 90.6 0.1 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Sialidase PF02973.11 KOO35400.1 - 0.0085 15.0 0.0 0.015 14.3 0.0 1.3 1 0 0 1 1 1 1 Sialidase, N-terminal domain Laminin_G_2 PF02210.19 KOO35400.1 - 0.033 14.2 0.0 0.064 13.2 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain SAP PF02037.22 KOO35400.1 - 0.16 11.5 2.5 0.2 11.1 0.1 2.4 3 0 0 3 3 3 0 SAP domain ARL2_Bind_BART PF11527.3 KOO35401.1 - 6.5e-05 22.7 0.2 9e-05 22.2 0.1 1.2 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART AMNp_N PF10423.4 KOO35401.1 - 0.14 11.7 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus RVT_2 PF07727.9 KOO35402.1 - 7.5e-17 61.1 0.0 1.1e-16 60.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HCR PF07111.7 KOO35402.1 - 0.2 9.6 0.0 0.29 9.0 0.0 1.1 1 0 0 1 1 1 0 Alpha helical coiled-coil rod protein (HCR) HECT PF00632.20 KOO35403.1 - 4.8e-32 111.3 0.0 7.5e-32 110.7 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) TraC PF07820.7 KOO35405.1 - 0.0071 16.5 3.0 0.0071 16.5 2.1 2.7 2 1 0 2 2 2 1 TraC-like protein 4F5 PF04419.9 KOO35405.1 - 0.015 16.0 10.4 0.015 16.0 7.2 3.0 2 1 0 2 2 2 0 4F5 protein family COPI_C PF06957.6 KOO35405.1 - 1.7 7.1 9.4 1.8 7.0 6.5 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus LRR_4 PF12799.2 KOO35406.1 - 1.4e-30 104.4 13.0 6.3e-08 32.0 0.0 6.1 3 1 3 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO35406.1 - 2.1e-20 72.2 20.0 4e-09 36.1 0.7 5.0 2 1 4 6 6 6 5 Leucine rich repeat LRR_9 PF14580.1 KOO35406.1 - 3.4e-11 42.9 3.4 1.8e-06 27.6 0.0 3.2 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.1 KOO35406.1 - 7.7e-10 37.8 14.4 0.54 10.4 0.2 8.3 4 3 4 8 8 8 4 Leucine Rich repeat LRR_1 PF00560.28 KOO35406.1 - 2.4e-09 35.9 25.1 0.5 10.5 0.0 9.7 9 2 2 11 11 11 5 Leucine Rich Repeat LRR_7 PF13504.1 KOO35406.1 - 2.6e-09 35.7 20.4 3.1 8.4 0.1 9.7 7 3 3 10 10 10 4 Leucine rich repeat DUF1034 PF06280.7 KOO35408.1 - 1.8e-05 25.0 2.3 57 4.1 0.0 6.1 6 0 0 6 6 6 0 Fn3-like domain (DUF1034) Alpha-2-MRAP_C PF06401.6 KOO35408.1 - 0.00026 20.9 6.0 15 5.3 0.1 4.3 4 0 0 4 4 4 4 Alpha-2-macroglobulin RAP, C-terminal domain NT-C2 PF10358.4 KOO35408.1 - 0.0028 17.1 0.0 2 7.8 0.0 3.7 3 0 0 3 3 3 1 N-terminal C2 in EEIG1 and EHBP1 proteins CEP76-C2 PF15627.1 KOO35408.1 - 0.0029 17.1 0.0 27 4.2 0.0 4.8 6 0 0 6 6 6 0 CEP76 C2 domain DUF1877 PF08974.5 KOO35408.1 - 0.73 9.4 6.3 1.4e+02 2.0 0.0 4.8 5 0 0 5 5 5 0 Domain of unknown function (DUF1877) Ribophorin_II PF05817.9 KOO35408.1 - 1.2 7.1 3.2 99 0.9 0.0 3.9 5 0 0 5 5 5 0 Oligosaccharyltransferase subunit Ribophorin II GIT_SHD PF08518.6 KOO35408.1 - 3.7 6.9 6.2 3.1e+02 0.8 0.0 4.8 5 0 0 5 5 5 0 Spa2 homology domain (SHD) of GIT PK PF00224.16 KOO35412.1 - 8.1e-140 465.3 1.0 1.1e-139 464.9 0.2 1.6 2 0 0 2 2 2 1 Pyruvate kinase, barrel domain PK_C PF02887.11 KOO35412.1 - 3.9e-19 68.3 0.4 1.1e-18 66.8 0.1 1.9 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.9 KOO35412.1 - 0.00087 18.2 0.2 0.0075 15.1 0.1 2.4 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family ACT_6 PF13740.1 KOO35413.1 - 1.9e-16 59.5 0.0 1.5e-11 43.8 0.0 2.6 2 0 0 2 2 2 2 ACT domain Mpv17_PMP22 PF04117.7 KOO35413.1 - 7.6e-11 41.4 3.2 8e-11 41.4 0.9 1.9 2 0 0 2 2 2 1 Mpv17 / PMP22 family ACT PF01842.20 KOO35413.1 - 1.2e-09 37.3 0.0 3.7e-05 23.0 0.0 2.5 2 0 0 2 2 2 2 ACT domain ACT_4 PF13291.1 KOO35413.1 - 1.6e-06 28.3 0.0 0.012 15.9 0.0 2.3 2 0 0 2 2 2 2 ACT domain Cupin_8 PF13621.1 KOO35414.1 - 0.092 12.2 0.0 0.097 12.1 0.0 1.1 1 0 0 1 1 1 0 Cupin-like domain EF-hand_7 PF13499.1 KOO35415.1 - 2.6e-11 43.4 0.1 5.6e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO35415.1 - 2.9e-09 36.4 3.6 0.00066 19.2 0.1 3.3 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO35415.1 - 4.7e-09 34.9 0.0 0.00013 21.0 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO35415.1 - 6.4e-07 28.7 0.1 4.5e-05 22.9 0.1 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.1 KOO35415.1 - 8.7e-07 28.0 0.4 0.00023 20.3 0.1 2.9 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.1 KOO35415.1 - 0.00073 19.3 0.1 0.0034 17.2 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain Ank_2 PF12796.2 KOO35416.1 - 8.7e-24 83.6 0.1 6.2e-12 45.6 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO35416.1 - 1e-20 73.2 2.2 3.3e-10 39.8 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO35416.1 - 2.8e-18 64.7 0.0 5.9e-09 35.2 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOO35416.1 - 2.7e-15 56.3 7.1 1.8e-05 25.0 0.2 3.8 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO35416.1 - 4.1e-12 45.1 0.1 0.00017 21.4 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Kelch_1 PF01344.20 KOO35417.1 - 5.6e-25 86.6 3.8 1.8e-06 27.3 0.0 6.0 6 1 0 6 6 6 4 Kelch motif Kelch_4 PF13418.1 KOO35417.1 - 2.6e-20 71.9 2.3 6.2e-05 22.6 0.0 5.9 5 1 0 5 5 5 5 Galactose oxidase, central domain Kelch_6 PF13964.1 KOO35417.1 - 6.1e-20 70.4 5.3 2.6e-05 24.1 0.0 6.5 2 1 4 6 6 6 4 Kelch motif Kelch_3 PF13415.1 KOO35417.1 - 5.3e-16 58.2 9.9 2.6e-05 24.2 0.0 5.9 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.10 KOO35417.1 - 4.4e-14 51.5 4.6 0.019 14.6 0.0 7.1 7 0 0 7 7 7 3 Kelch motif Kelch_5 PF13854.1 KOO35417.1 - 4.8e-14 51.9 3.4 0.0057 16.5 0.0 5.7 6 0 0 6 6 6 3 Kelch motif EF-hand_1 PF00036.27 KOO35418.1 - 5e-08 31.6 0.0 0.018 14.3 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO35418.1 - 6.8e-08 31.7 0.1 0.017 14.9 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 KOO35418.1 - 3.8e-07 29.6 1.2 0.026 14.1 0.1 3.6 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.1 KOO35418.1 - 1.1e-05 25.4 0.2 0.00059 19.9 0.2 2.7 1 1 0 1 1 1 1 EF-hand domain pair HMG_box PF00505.14 KOO35418.1 - 1.3e-05 25.3 39.9 0.074 13.3 0.3 8.1 5 4 5 10 10 9 3 HMG (high mobility group) box LTXXQ PF07813.7 KOO35418.1 - 9e-05 22.8 46.8 0.014 15.8 4.1 5.5 2 2 3 5 5 5 2 LTXXQ motif family protein Catalase-rel PF06628.7 KOO35418.1 - 0.00034 20.4 13.0 17 5.3 0.0 7.8 5 4 1 9 9 9 0 Catalase-related immune-responsive DUF4473 PF14747.1 KOO35418.1 - 0.00076 19.6 23.7 0.17 12.1 0.3 6.0 3 2 1 5 5 5 2 Domain of unknown function (DUF4473) DUF3106 PF11304.3 KOO35418.1 - 0.0011 19.3 24.9 0.23 11.8 2.3 5.4 2 1 1 4 4 3 2 Protein of unknown function (DUF3106) MgtE_N PF03448.12 KOO35418.1 - 0.0039 17.4 19.7 0.19 12.0 0.8 4.7 4 1 0 4 4 4 2 MgtE intracellular N domain HMG_box_2 PF09011.5 KOO35418.1 - 0.0093 16.3 40.9 0.6 10.5 0.2 7.7 3 3 4 7 7 7 4 HMG-box domain HSP9_HSP12 PF04119.7 KOO35418.1 - 0.019 15.0 0.0 0.93 9.6 0.0 3.4 3 1 0 3 3 3 0 Heat shock protein 9/12 DUF1104 PF06518.6 KOO35418.1 - 0.061 13.4 34.4 1.4 9.1 1.0 6.1 4 2 1 5 5 5 0 Protein of unknown function (DUF1104) IspD PF01128.14 KOO35418.1 - 0.077 12.5 0.2 0.13 11.7 0.1 1.4 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Acetyltransf_10 PF13673.1 KOO35418.1 - 0.2 11.8 4.3 9.1 6.4 0.0 3.8 3 1 1 4 4 4 0 Acetyltransferase (GNAT) domain Sdh5 PF03937.11 KOO35418.1 - 0.84 9.3 6.9 1.9 8.2 0.1 4.6 4 2 1 5 5 5 0 Flavinator of succinate dehydrogenase TerB-N PF13208.1 KOO35418.1 - 2.1 7.7 14.8 14 5.0 0.6 5.5 4 3 0 4 4 4 0 TerB-N Peptidase_S49 PF01343.13 KOO35418.1 - 3.6 7.3 13.4 9.9 5.9 0.1 4.8 3 2 2 5 5 5 0 Peptidase family S49 Dynein_heavy PF03028.10 KOO35419.1 - 7.5e-68 229.2 0.0 2.4e-62 211.0 0.0 2.1 2 0 0 2 2 2 2 Dynein heavy chain and region D6 of dynein motor AAA_9 PF12781.2 KOO35419.1 - 1.8e-16 59.6 0.0 1.1e-15 57.1 0.0 2.0 2 0 0 2 2 2 1 ATP-binding dynein motor region D5 Dynein_heavy PF03028.10 KOO35420.1 - 6.9e-48 163.2 0.0 7.9e-48 163.0 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor Rubis-subs-bind PF09273.6 KOO35422.1 - 0.0032 17.3 0.4 0.032 14.1 0.1 2.4 2 1 0 2 2 2 1 Rubisco LSMT substrate-binding AAA_16 PF13191.1 KOO35422.1 - 0.02 14.8 0.8 0.032 14.2 0.5 1.5 1 1 0 1 1 1 0 AAA ATPase domain EcsC PF12787.2 KOO35422.1 - 0.14 11.5 0.0 0.17 11.2 0.0 1.1 1 0 0 1 1 1 0 EcsC protein family SpaB_C PF14028.1 KOO35422.1 - 5.8 6.3 11.8 3.7 7.0 6.9 1.5 1 1 1 2 2 2 0 SpaB C-terminal domain PUA PF01472.15 KOO35423.1 - 6.7e-09 35.3 0.2 1.2e-08 34.5 0.2 1.4 1 0 0 1 1 1 1 PUA domain Nol1_Nop2_Fmu PF01189.12 KOO35423.1 - 7e-08 32.1 0.0 2.6e-07 30.3 0.0 1.7 2 0 0 2 2 2 1 NOL1/NOP2/sun family Pkinase PF00069.20 KOO35424.1 - 1.3e-66 224.3 0.0 1.5e-66 224.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO35424.1 - 1.2e-31 109.7 0.0 1.5e-31 109.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO35424.1 - 0.015 15.0 0.0 0.035 13.8 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO35424.1 - 0.019 13.9 0.0 0.068 12.1 0.0 1.7 1 1 0 2 2 2 0 Kinase-like OCC1 PF15506.1 KOO35426.1 - 0.88 9.4 7.1 6.1 6.7 0.8 2.6 1 1 2 3 3 3 0 OCC1 family DnaJ PF00226.26 KOO35427.1 - 3e-12 46.1 0.0 8.1e-12 44.7 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain TFIIF_alpha PF05793.7 KOO35427.1 - 0.0023 16.4 8.9 0.0023 16.4 6.2 2.3 3 0 0 3 3 3 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) OmpH PF03938.9 KOO35427.1 - 0.0035 17.2 6.0 0.0035 17.2 4.1 3.3 3 0 0 3 3 3 1 Outer membrane protein (OmpH-like) AP2 PF00847.15 KOO35428.1 - 1.1e-22 79.9 103.7 7.6e-05 22.7 0.0 15.2 14 5 2 16 16 16 10 AP2 domain IF3_N PF05198.11 KOO35428.1 - 0.0005 19.9 19.7 9.3 6.2 0.0 8.6 9 0 0 9 9 9 2 Translation initiation factor IF-3, N-terminal domain CedA PF10729.4 KOO35428.1 - 0.049 13.1 0.0 13 5.4 0.0 4.7 6 0 0 6 6 6 0 Cell division activator CedA HCV_NS5a_1a PF08300.8 KOO35428.1 - 0.94 9.4 4.3 62 3.6 0.1 5.0 7 0 0 7 7 7 0 Hepatitis C virus non-structural 5a zinc finger domain Aconitase PF00330.15 KOO35430.1 - 7.6e-174 578.5 0.0 8.9e-174 578.3 0.0 1.0 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 KOO35430.1 - 2.9e-36 124.4 0.0 5.2e-36 123.6 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain DEAD PF00270.24 KOO35431.1 - 5.5e-33 113.8 0.0 7.6e-31 106.8 0.0 2.9 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO35431.1 - 9.2e-26 89.5 0.0 2.6e-25 88.0 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 KOO35431.1 - 0.084 13.0 0.1 0.39 10.8 0.1 2.0 1 1 0 1 1 1 0 AAA domain Peptidase_C1 PF00112.18 KOO35432.1 - 1.2e-41 143.0 0.0 1.7e-41 142.5 0.0 1.2 1 1 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.10 KOO35432.1 - 0.02 13.4 0.6 0.031 12.8 0.4 1.1 1 0 0 1 1 1 0 Peptidase C1-like family Ank_2 PF12796.2 KOO35434.1 - 2.4e-13 50.2 0.0 6.1e-13 48.9 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO35434.1 - 3.9e-12 45.3 0.1 2e-05 24.1 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 KOO35434.1 - 6.7e-09 36.0 0.3 0.0073 16.7 0.0 3.0 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO35434.1 - 7e-09 35.0 0.2 0.014 15.5 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 KOO35434.1 - 5.2e-07 29.7 1.6 0.0031 17.7 0.1 3.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Lon_C PF05362.8 KOO35435.1 - 5e-64 215.3 0.0 1.4e-61 207.3 0.0 2.3 1 1 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.24 KOO35435.1 - 1.6e-12 47.7 0.0 4.7e-08 33.3 0.0 2.6 1 1 1 2 2 2 2 ATPase family associated with various cellular activities (AAA) ChlI PF13541.1 KOO35435.1 - 2.8e-07 30.0 0.0 8.7e-07 28.4 0.0 1.9 1 1 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.9 KOO35435.1 - 7.7e-07 28.9 0.0 7.4e-06 25.7 0.0 2.3 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOO35435.1 - 3.5e-06 27.1 0.1 9e-06 25.7 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 KOO35435.1 - 1.8e-05 25.5 0.0 4e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_PrkA PF08298.6 KOO35435.1 - 2.2e-05 23.3 0.0 3.6e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 PrkA AAA domain AAA_33 PF13671.1 KOO35435.1 - 0.00011 22.0 0.1 0.024 14.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.7 KOO35435.1 - 0.00013 21.0 0.0 0.00031 19.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus IstB_IS21 PF01695.12 KOO35435.1 - 0.0053 16.1 0.0 0.027 13.8 0.0 2.1 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_3 PF07726.6 KOO35435.1 - 0.0062 16.1 0.0 0.015 14.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOO35435.1 - 0.009 16.1 0.0 0.021 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 KOO35435.1 - 0.0096 16.2 0.1 0.019 15.2 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 KOO35435.1 - 0.01 15.4 0.1 0.016 14.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 KOO35435.1 - 0.012 14.8 0.0 0.021 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_19 PF13245.1 KOO35435.1 - 0.013 15.1 0.4 0.062 13.0 0.3 2.3 1 0 0 1 1 1 0 Part of AAA domain AAA_25 PF13481.1 KOO35435.1 - 0.021 14.1 0.0 0.077 12.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 KOO35435.1 - 0.03 14.4 0.0 0.054 13.6 0.0 1.4 1 0 0 1 1 1 0 RNA helicase UPF0079 PF02367.12 KOO35435.1 - 0.031 13.9 0.0 0.058 13.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 NACHT PF05729.7 KOO35435.1 - 0.058 13.0 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 NACHT domain TIP49 PF06068.8 KOO35435.1 - 0.071 11.8 0.1 2.1 6.9 0.0 2.1 2 0 0 2 2 2 0 TIP49 C-terminus SKI PF01202.17 KOO35435.1 - 0.078 12.8 0.2 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 Shikimate kinase ABC_tran PF00005.22 KOO35435.1 - 0.098 12.9 0.0 0.23 11.7 0.0 1.7 1 0 0 1 1 1 0 ABC transporter CCDC-167 PF15188.1 KOO35435.1 - 0.15 11.9 0.7 0.46 10.4 0.1 2.0 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 AAA_23 PF13476.1 KOO35435.1 - 0.26 11.5 0.0 0.41 10.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain LON PF02190.11 KOO35436.1 - 3.1e-15 56.3 0.0 4.2e-15 55.9 0.0 1.2 1 0 0 1 1 1 1 ATP-dependent protease La (LON) domain Amidohydro_2 PF04909.9 KOO35437.1 - 2.8e-06 27.0 0.8 2.8e-06 27.0 0.5 1.7 2 0 0 2 2 2 1 Amidohydrolase Peptidase_S49_N PF08496.5 KOO35437.1 - 0.0021 17.8 0.2 0.0031 17.3 0.1 1.2 1 0 0 1 1 1 1 Peptidase family S49 N-terminal DUF3987 PF13148.1 KOO35437.1 - 0.044 12.3 0.4 0.061 11.8 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) EzrA PF06160.7 KOO35437.1 - 0.086 11.0 0.1 0.11 10.6 0.1 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA HK97-gp10_like PF04883.7 KOO35437.1 - 0.15 12.9 1.4 0.42 11.5 1.0 1.8 1 0 0 1 1 1 0 Bacteriophage HK97-gp10, putative tail-component Herpes_UL25 PF01499.11 KOO35437.1 - 0.8 7.9 3.1 1.1 7.4 2.1 1.1 1 0 0 1 1 1 0 Herpesvirus UL25 family Toprim_C_rpt PF13368.1 KOO35437.1 - 9 6.8 8.9 2.6 8.6 3.8 1.8 2 0 0 2 2 2 0 Topoisomerase C-terminal repeat TPR_11 PF13414.1 KOO35438.1 - 2e-10 40.1 4.1 0.00017 21.2 0.1 2.6 3 0 0 3 3 3 2 TPR repeat TPR_16 PF13432.1 KOO35438.1 - 0.00018 22.0 2.8 0.00018 22.0 1.9 3.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO35438.1 - 0.00018 20.9 2.0 0.64 9.7 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO35438.1 - 0.00025 20.7 12.1 0.011 15.5 0.3 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat DUF2786 PF10979.3 KOO35438.1 - 0.0077 15.9 3.7 0.032 13.9 0.1 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2786) NARP1 PF12569.3 KOO35438.1 - 0.03 13.0 2.3 0.068 11.9 0.0 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 TPR_19 PF14559.1 KOO35438.1 - 0.44 10.9 6.4 0.078 13.3 1.3 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO35438.1 - 6.3 6.8 7.9 8.2 6.4 0.2 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_L3 PF00297.17 KOO35439.1 - 3.9e-33 114.9 2.9 2.8e-31 108.8 2.0 2.1 1 1 0 1 1 1 1 Ribosomal protein L3 Ribosomal_S30 PF04758.9 KOO35440.1 - 3.7e-30 103.4 10.7 4.2e-30 103.2 7.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 PP2C PF00481.16 KOO35442.1 - 2.5e-43 148.3 0.5 4.8e-28 98.2 0.1 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.7 KOO35442.1 - 0.00026 20.7 0.1 0.0061 16.2 0.0 2.1 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 KOO35442.1 - 0.00057 19.3 0.1 0.055 12.8 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C COesterase PF00135.23 KOO35443.1 - 3.8e-91 306.4 0.0 1.5e-68 231.8 0.1 3.0 2 1 0 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.8 KOO35443.1 - 2.4e-05 24.0 0.2 0.00014 21.5 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 KOO35443.1 - 0.0099 15.1 0.0 0.019 14.2 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family PAN_2 PF08276.6 KOO35443.1 - 0.016 15.0 0.8 0.035 13.9 0.6 1.6 1 0 0 1 1 1 0 PAN-like domain Sec20 PF03908.8 KOO35444.1 - 0.11 12.1 0.6 1 9.1 0.1 2.5 2 1 1 3 3 3 0 Sec20 ENT PF03735.9 KOO35444.1 - 0.12 12.0 4.7 0.53 10.0 2.8 2.4 1 1 1 2 2 2 0 ENT domain OmpH PF03938.9 KOO35444.1 - 0.54 10.1 19.8 1.9 8.3 11.0 2.7 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) HBS1_N PF08938.5 KOO35444.1 - 0.69 10.0 5.7 3.5 7.8 3.9 2.4 1 1 0 1 1 1 0 HBS1 N-terminus DUF1682 PF07946.9 KOO35444.1 - 4.6 5.9 9.0 8.2 5.1 6.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DUF4200 PF13863.1 KOO35444.1 - 6.6 6.6 24.3 1.8 8.4 0.1 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) PP2C PF00481.16 KOO35445.1 - 1.2e-64 218.1 0.0 1.5e-64 217.8 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 KOO35445.1 - 6.1e-10 38.8 0.1 8.7e-10 38.3 0.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOO35445.1 - 0.001 18.7 0.6 0.0044 16.7 0.4 1.8 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) zf-HYPF PF07503.7 KOO35446.1 - 0.0027 17.0 17.8 1.7 8.1 0.2 5.0 4 0 0 4 4 4 3 HypF finger DNA_RNApol_7kD PF03604.8 KOO35446.1 - 0.76 9.2 9.2 14 5.2 0.1 4.6 4 0 0 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit Toxin_19 PF08088.7 KOO35446.1 - 0.92 9.4 15.8 22 5.0 0.2 5.1 4 0 0 4 4 4 0 Conotoxin I-superfamily zf-CCHH PF10283.4 KOO35446.1 - 0.98 9.3 16.9 23 4.9 0.3 4.5 4 0 0 4 4 4 0 Zinc-finger (CX5CX6HX5H) motif CAP_N PF01213.14 KOO35446.1 - 8.8 5.5 15.7 0.31 10.2 1.6 2.7 2 1 1 3 3 3 0 Adenylate cyclase associated (CAP) N terminal zf-RING_2 PF13639.1 KOO35447.1 - 8.9e-14 51.0 5.6 8.9e-14 51.0 3.9 4.2 3 1 0 3 3 3 1 Ring finger domain CUB PF00431.15 KOO35447.1 - 1.8e-12 47.3 0.0 1.6e-09 37.7 0.0 2.6 2 0 0 2 2 2 2 CUB domain zf-RING_5 PF14634.1 KOO35447.1 - 2.1e-06 27.3 4.2 2.1e-06 27.3 2.9 5.4 6 0 0 6 6 6 1 zinc-RING finger domain Cadherin-like PF12733.2 KOO35447.1 - 7.1e-06 26.2 1.1 0.51 10.6 0.0 4.9 5 0 0 5 5 5 2 Cadherin-like beta sandwich domain DUF3550 PF12070.3 KOO35447.1 - 0.34 9.5 0.0 0.5 9.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3550/UPF0682) LVIVD PF08309.6 KOO35449.1 - 1.3e-50 168.1 51.6 4.9e-11 41.4 2.4 6.2 6 0 0 6 6 6 6 LVIVD repeat Beta_propel PF09826.4 KOO35449.1 - 5.6e-05 21.6 0.0 3.7 5.7 0.0 4.5 5 0 0 5 5 5 3 Beta propeller domain Chitin_bind_4 PF00379.18 KOO35449.1 - 0.00075 19.7 9.7 14 6.0 0.1 6.1 6 0 0 6 6 6 1 Insect cuticle protein SBP56 PF05694.6 KOO35449.1 - 0.0019 16.7 0.0 0.36 9.2 0.0 3.5 2 1 1 4 4 4 1 56kDa selenium binding protein (SBP56) Lactonase PF10282.4 KOO35449.1 - 0.0073 15.4 4.1 1.9 7.4 1.2 3.6 2 1 1 3 3 3 2 Lactonase, 7-bladed beta-propeller MTTB PF06253.6 KOO35449.1 - 1.2 6.7 10.8 2.5 5.7 0.1 4.0 3 1 2 5 5 5 0 Trimethylamine methyltransferase (MTTB) MRJP PF03022.11 KOO35449.1 - 2.3 7.3 11.1 1.7 7.7 0.2 4.2 4 1 1 5 5 5 0 Major royal jelly protein IQ PF00612.22 KOO35450.1 - 0.04 13.5 0.1 0.11 12.2 0.1 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif Acetyltransf_10 PF13673.1 KOO35451.1 - 8e-05 22.7 0.2 0.0002 21.4 0.1 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 KOO35451.1 - 0.0002 21.3 0.0 0.00083 19.3 0.0 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 KOO35451.1 - 0.00021 21.3 0.0 0.00042 20.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain IBR PF01485.16 KOO35453.1 - 1.2e-17 63.5 51.3 8.3e-12 44.8 2.8 5.0 4 1 1 5 5 5 2 IBR domain zf-C3HC4_3 PF13920.1 KOO35453.1 - 0.0027 17.3 7.6 0.0027 17.3 5.2 4.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO35453.1 - 0.0033 17.4 9.2 0.0033 17.4 6.4 5.1 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO35453.1 - 0.0037 16.8 6.6 0.0037 16.8 4.6 4.6 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO35453.1 - 0.0055 16.5 8.8 0.0055 16.5 6.1 3.9 2 1 1 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.1 KOO35453.1 - 0.0095 15.6 2.2 0.0095 15.6 1.5 3.1 3 0 0 3 3 3 1 RING-type zinc-finger BAG PF02179.11 KOO35453.1 - 0.16 12.0 3.4 0.13 12.3 0.8 1.9 2 0 0 2 2 2 0 BAG domain zf-RING_5 PF14634.1 KOO35453.1 - 3 7.6 42.5 0.25 11.1 5.4 4.0 3 1 0 3 3 3 0 zinc-RING finger domain CENP-B_dimeris PF09026.5 KOO35456.1 - 0.034 14.3 1.1 0.041 14.1 0.7 1.1 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FTCD_C PF04961.7 KOO35456.1 - 0.051 12.9 1.1 0.049 13.0 0.8 1.0 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase Herpes_LMP1 PF05297.6 KOO35456.1 - 0.27 10.1 1.1 0.29 10.0 0.8 1.0 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) BRCT PF00533.21 KOO35457.1 - 1.7e-05 24.8 0.0 6.3e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 KOO35457.1 - 0.028 14.2 0.1 0.074 12.9 0.0 1.6 1 0 0 1 1 1 0 twin BRCT domain DUF4033 PF13225.1 KOO35457.1 - 0.15 11.6 0.1 0.28 10.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4033) Atg14 PF10186.4 KOO35457.1 - 0.34 9.8 2.0 0.51 9.2 1.4 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Arm PF00514.18 KOO35458.1 - 7e-16 57.3 9.7 0.00087 19.0 0.0 5.1 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat EF-hand_8 PF13833.1 KOO35458.1 - 1.4e-06 27.7 0.1 0.00053 19.5 0.0 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO35458.1 - 4.2e-06 26.1 0.1 4.3e-05 23.0 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 KOO35458.1 - 1.5e-05 23.9 0.1 9.9e-05 21.3 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.1 KOO35458.1 - 2e-05 23.6 0.1 4.9e-05 22.4 0.1 1.7 1 0 0 1 1 1 1 EF hand HEAT_2 PF13646.1 KOO35458.1 - 5.2e-05 23.4 9.5 0.00029 21.0 1.0 4.1 3 1 3 6 6 6 3 HEAT repeats EF-hand_7 PF13499.1 KOO35458.1 - 0.0011 19.1 0.0 0.0023 18.0 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair Arm_2 PF04826.8 KOO35458.1 - 0.019 14.0 0.1 0.43 9.6 0.0 2.3 1 1 1 2 2 2 0 Armadillo-like HEAT PF02985.17 KOO35458.1 - 0.044 13.8 8.7 2.8 8.2 0.0 4.8 5 1 0 5 5 5 0 HEAT repeat Proteasom_PSMB PF10508.4 KOO35458.1 - 0.064 11.5 0.0 0.096 10.9 0.0 1.2 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit PAP_central PF04928.12 KOO35459.1 - 2.5 6.8 6.3 14 4.3 0.1 3.4 3 0 0 3 3 3 0 Poly(A) polymerase central domain Med3 PF11593.3 KOO35460.1 - 2.2 7.4 6.3 0.72 9.0 1.7 1.8 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal EF-hand_1 PF00036.27 KOO35461.1 - 1.1e-21 74.3 5.6 4.1e-05 22.5 0.5 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO35461.1 - 1.1e-20 73.5 0.5 7.5e-11 42.0 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO35461.1 - 1.2e-16 59.1 6.7 1.3e-05 24.2 0.0 4.7 4 1 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 KOO35461.1 - 1.7e-16 58.5 1.0 0.0024 17.6 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 KOO35461.1 - 1.5e-11 43.7 6.3 6.2e-07 28.9 0.1 4.0 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO35461.1 - 5.4e-07 29.6 0.1 7.9e-05 22.6 0.0 2.6 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO35461.1 - 0.0022 17.6 4.7 2.8 7.7 0.0 3.8 2 2 1 4 4 4 1 Cytoskeletal-regulatory complex EF hand FG-GAP PF01839.18 KOO35461.1 - 0.37 10.5 8.0 6.4 6.6 0.1 3.2 3 0 0 3 3 3 0 FG-GAP repeat VCBS PF13517.1 KOO35461.1 - 0.87 9.9 4.9 28 5.1 0.0 3.4 3 1 0 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Borrelia_P83 PF05262.6 KOO35462.1 - 0.2 9.8 4.8 0.15 10.3 2.5 1.3 2 0 0 2 2 2 0 Borrelia P83/100 protein CBFB_NFYA PF02045.10 KOO35462.1 - 2.2 8.8 13.4 7 7.2 0.1 3.3 2 1 1 3 3 3 0 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B EPSP_synthase PF00275.15 KOO35463.1 - 4.5e-64 216.4 0.1 1.4e-36 125.8 0.0 3.0 2 1 1 3 3 3 3 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) TPD PF14811.1 KOO35464.1 - 1.4e-16 60.2 0.1 2.4e-15 56.2 0.0 2.6 3 0 0 3 3 3 1 Protein of unknown function TPD sequence-motif Rad60-SLD PF11976.3 KOO35464.1 - 0.0056 16.3 0.0 0.15 11.8 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like DUF3106 PF11304.3 KOO35465.1 - 0.42 11.0 3.0 2.6 8.4 2.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3106) Myb_DNA-binding PF00249.26 KOO35466.1 - 5.3e-23 80.8 0.8 2.9e-14 52.8 0.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO35466.1 - 1.2e-16 60.5 0.4 1.7e-14 53.6 0.1 2.2 1 1 1 2 2 2 2 Myb-like DNA-binding domain Rap1_C PF11626.3 KOO35466.1 - 0.13 12.1 0.6 3.4 7.6 0.4 2.3 1 1 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain PGC7_Stella PF15549.1 KOO35467.1 - 0.09 12.7 1.3 0.13 12.2 0.9 1.2 1 0 0 1 1 1 0 PGC7/Stella/Dppa3 domain PARP PF00644.15 KOO35468.1 - 6.2e-12 45.3 0.0 1.2e-11 44.4 0.0 1.5 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain RRN7 PF11781.3 KOO35469.1 - 0.091 12.2 1.9 0.51 9.8 0.1 2.1 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 Methyltransf_18 PF12847.2 KOO35470.1 - 0.097 13.2 0.0 0.33 11.5 0.0 1.9 2 1 0 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.13 KOO35470.1 - 0.13 11.3 0.0 0.18 10.9 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.1 KOO35470.1 - 0.13 11.9 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.10 KOO35470.1 - 0.13 11.5 0.1 0.19 11.1 0.1 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 EF-hand_7 PF13499.1 KOO35471.1 - 2.5e-09 37.1 0.3 2.3e-06 27.6 0.1 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO35471.1 - 1.5e-07 30.7 0.1 0.075 12.9 0.0 4.0 3 1 1 4 4 4 2 EF-hand domain EF-hand_9 PF14658.1 KOO35471.1 - 9.7e-07 28.6 0.0 0.0017 18.2 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO35471.1 - 4.8e-06 25.4 0.1 0.17 11.2 0.0 3.6 4 0 0 4 4 4 2 EF hand EFhand_Ca_insen PF08726.5 KOO35471.1 - 0.00049 20.0 0.1 0.00091 19.1 0.0 1.4 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_8 PF13833.1 KOO35471.1 - 0.014 14.9 0.6 4 7.1 0.0 3.3 3 1 1 4 4 4 0 EF-hand domain pair APC2 PF08672.6 KOO35471.1 - 0.043 14.0 0.0 0.56 10.4 0.0 2.2 2 0 0 2 2 2 0 Anaphase promoting complex (APC) subunit 2 WASH-7_mid PF14744.1 KOO35471.1 - 0.044 12.6 0.0 0.061 12.1 0.0 1.1 1 0 0 1 1 1 0 WASH complex subunit 7 Ribosomal_S13 PF00416.17 KOO35474.1 - 8e-39 132.3 1.6 9.6e-39 132.1 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.6 KOO35474.1 - 0.0008 18.0 0.0 0.0012 17.5 0.0 1.3 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) EF-hand_8 PF13833.1 KOO35474.1 - 0.014 14.9 0.1 0.074 12.6 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain pair Ribosomal_L28e PF01778.12 KOO35474.1 - 0.027 14.8 0.2 0.041 14.3 0.1 1.3 1 0 0 1 1 1 0 Ribosomal L28e protein family DUF524 PF04411.7 KOO35474.1 - 0.11 12.3 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF524) His_Phos_1 PF00300.17 KOO35475.1 - 2.9e-25 89.2 0.0 6.1e-25 88.1 0.0 1.6 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Cyclin_N PF00134.18 KOO35475.1 - 2.1e-11 43.4 0.0 3.9e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain UPF0193 PF05250.6 KOO35476.1 - 2.3e-09 37.1 0.3 4.6e-09 36.1 0.2 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0193) TauE PF01925.14 KOO35477.1 - 4.1e-24 85.3 19.3 2.3e-13 50.1 0.1 2.3 2 0 0 2 2 2 2 Sulfite exporter TauE/SafE DUF2076 PF09849.4 KOO35477.1 - 0.022 14.8 0.0 0.09 12.8 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF4412 PF14371.1 KOO35480.1 - 0.011 16.1 0.0 0.017 15.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4412) TPR_11 PF13414.1 KOO35482.1 - 0.0035 16.9 0.8 0.0085 15.7 0.5 1.6 1 0 0 1 1 1 1 TPR repeat Daxx PF03344.10 KOO35483.1 - 3.8 5.8 7.0 4.8 5.5 4.9 1.3 1 0 0 1 1 1 0 Daxx Family SDA1 PF05285.7 KOO35483.1 - 4 6.6 10.2 4.8 6.3 7.1 1.2 1 0 0 1 1 1 0 SDA1 RVT_2 PF07727.9 KOO35484.1 - 5.1e-11 42.0 0.0 9.1e-11 41.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) GPS PF01825.16 KOO35485.1 - 2.5e-10 40.3 8.2 6e-10 39.0 5.7 1.6 1 0 0 1 1 1 1 Latrophilin/CL-1-like GPS domain PDZ_2 PF13180.1 KOO35485.1 - 0.021 14.6 0.0 0.057 13.3 0.0 1.8 1 0 0 1 1 1 0 PDZ domain Cyclotide PF03784.8 KOO35487.1 - 0.89 9.4 4.4 0.33 10.8 0.3 2.4 2 0 0 2 2 2 0 Cyclotide family TFIIS_M PF07500.9 KOO35489.1 - 3.9e-18 65.5 0.2 7.1e-18 64.7 0.0 1.4 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain Nop14 PF04147.7 KOO35489.1 - 7.8 4.2 10.8 9.8 3.9 7.5 1.2 1 0 0 1 1 1 0 Nop14-like family Pkinase PF00069.20 KOO35490.1 - 1.9e-39 135.4 0.0 2.6e-39 134.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO35490.1 - 1.1e-16 60.6 0.0 1.7e-16 60.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO35490.1 - 0.0024 17.6 1.5 0.0027 17.4 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 KOO35490.1 - 0.006 15.6 0.0 0.009 15.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family GP4 PF03010.9 KOO35491.1 - 0.058 12.9 0.7 0.12 12.0 0.5 1.5 1 0 0 1 1 1 0 GP4 Filamin PF00630.14 KOO35492.1 - 0.00016 22.1 0.0 0.00016 22.1 0.0 1.2 1 0 0 1 1 1 1 Filamin/ABP280 repeat Epimerase PF01370.16 KOO35493.1 - 3e-67 226.4 0.1 4.1e-67 226.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 KOO35493.1 - 6.7e-05 21.9 0.0 0.00011 21.2 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase_Csub PF13950.1 KOO35493.1 - 0.0041 17.0 0.0 0.0085 16.0 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit NAD_binding_10 PF13460.1 KOO35493.1 - 0.029 14.3 0.0 0.08 12.9 0.0 1.7 1 0 0 1 1 1 0 NADH(P)-binding MRP-L47 PF06984.8 KOO35494.1 - 0.0089 15.9 0.5 0.017 15.0 0.3 1.5 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) TPR_11 PF13414.1 KOO35495.1 - 2.1e-18 65.7 15.2 4.8e-09 35.7 0.4 4.0 1 1 4 5 5 5 4 TPR repeat TPR_2 PF07719.12 KOO35495.1 - 1.3e-14 52.8 19.6 0.00083 19.0 0.2 6.0 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_16 PF13432.1 KOO35495.1 - 4.3e-14 52.7 33.9 3.2e-09 37.1 2.5 4.6 3 1 0 3 3 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO35495.1 - 1.8e-13 49.4 1.0 0.0026 17.2 0.2 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOO35495.1 - 1.5e-10 40.8 17.4 0.00029 20.6 0.6 3.8 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO35495.1 - 7e-07 28.9 4.0 0.028 14.5 0.0 4.2 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO35495.1 - 3.1e-06 26.5 4.0 0.04 13.7 0.2 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO35495.1 - 9.6e-06 25.8 6.7 0.0045 17.2 0.2 3.6 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.1 KOO35495.1 - 1.1e-05 25.2 22.7 0.43 10.5 0.2 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.1 KOO35495.1 - 0.0023 18.3 31.6 0.2 12.3 0.7 6.2 2 1 4 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO35495.1 - 0.0024 17.5 1.8 0.12 12.2 0.0 4.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.1 KOO35495.1 - 0.0062 16.9 14.3 2.3 8.8 0.2 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOO35495.1 - 0.016 15.0 15.0 0.6 10.0 3.3 3.6 1 1 2 3 3 3 0 Tetratricopeptide repeat Exonuc_VII_L PF02601.10 KOO35498.1 - 1.8 7.6 12.9 22 4.0 9.0 2.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF374 PF04028.8 KOO35499.1 - 0.059 12.6 0.1 0.067 12.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF374) rRNA_proc-arch PF13234.1 KOO35500.1 - 0.044 12.9 0.0 0.055 12.6 0.0 1.2 1 0 0 1 1 1 0 rRNA-processing arch domain Histone PF00125.19 KOO35504.1 - 9.5e-23 80.1 0.1 1.6e-22 79.4 0.1 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 KOO35504.1 - 9.6e-07 28.7 0.0 1.4e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DSRB PF10781.4 KOO35505.1 - 3.8e-08 32.6 3.6 3.8 7.0 0.1 5.2 5 0 0 5 5 5 5 Dextransucrase DSRB LIME1 PF15332.1 KOO35505.1 - 0.081 12.1 3.4 0.29 10.3 0.1 2.8 1 1 1 3 3 3 0 Lck-interacting transmembrane adapter 1 Ribosomal_L32e PF01655.13 KOO35505.1 - 8.2 6.5 8.6 8.9 6.4 0.5 3.2 3 0 0 3 3 3 0 Ribosomal protein L32 VCBS PF13517.1 KOO35506.1 - 4e-125 408.2 144.6 2.8e-14 53.2 3.9 12.1 1 1 11 12 12 12 12 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO35506.1 - 1.4e-67 221.9 124.0 5.4e-06 25.9 0.1 13.4 13 0 0 13 13 13 13 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO35506.1 - 1.3e-25 89.8 43.7 0.03 13.7 0.1 12.1 2 2 10 12 12 12 12 Insecticide toxin TcdB middle/N-terminal region BBS2_Mid PF14783.1 KOO35506.1 - 0.001 18.7 12.9 64 3.3 0.0 9.7 12 0 0 12 12 12 0 Ciliary BBSome complex subunit 2, middle region EF-hand_1 PF00036.27 KOO35506.1 - 0.31 10.4 58.3 12 5.5 0.2 12.3 12 0 0 12 12 12 0 EF hand HET-s_218-289 PF11558.3 KOO35506.1 - 0.42 10.6 15.6 4.3 7.3 0.2 7.0 8 0 0 8 8 8 0 Het-s 218-289 Glyco_transf_56 PF07429.6 KOO35506.1 - 0.93 8.3 2.9 1.3e+02 1.2 0.0 4.8 7 0 0 7 7 7 0 4-alpha-L-fucosyltransferase glycosyl transferase group 56 Paramyxo_PNT PF13825.1 KOO35506.1 - 1.9 7.5 3.0 7.5 5.6 0.0 3.1 3 0 0 3 3 3 0 Paramyxovirus structural protein V/P N-terminus BBS1 PF14779.1 KOO35506.1 - 3.4 6.5 15.0 7.8 5.3 0.0 6.8 11 0 0 11 11 11 0 Ciliary BBSome complex subunit 1 TPR_11 PF13414.1 KOO35507.1 - 3.4e-08 33.0 2.5 3.4e-08 33.0 1.8 3.1 3 0 0 3 3 3 2 TPR repeat TPR_8 PF13181.1 KOO35507.1 - 5.3e-05 22.6 0.0 0.55 10.1 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO35507.1 - 0.00052 19.7 10.8 0.007 16.2 0.1 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO35507.1 - 0.0057 16.4 0.3 0.0057 16.4 0.2 2.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO35507.1 - 0.0096 16.5 1.4 0.0096 16.5 1.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO35507.1 - 7.1 6.4 12.3 1.6 8.4 0.3 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Pkinase PF00069.20 KOO35508.1 - 1.6e-35 122.5 0.0 2e-35 122.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO35508.1 - 1.3e-26 93.2 0.0 2.2e-26 92.4 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO35508.1 - 0.0002 20.4 0.0 0.00026 20.0 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO35508.1 - 0.011 15.4 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family PTPS PF01242.14 KOO35509.1 - 0.0048 16.5 0.0 0.0052 16.4 0.0 1.0 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase EF-hand_1 PF00036.27 KOO35510.1 - 2.3e-09 35.8 0.0 0.0024 17.0 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO35510.1 - 7.4e-08 31.6 0.0 0.0095 15.7 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain Myb_DNA-bind_6 PF13921.1 KOO35510.1 - 1.2e-07 31.6 0.3 7.9e-07 29.0 0.1 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain EF-hand_7 PF13499.1 KOO35510.1 - 5.4e-07 29.6 0.0 1.3e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO35510.1 - 1.3e-06 27.5 0.0 0.023 14.0 0.0 2.6 2 0 0 2 2 2 2 EF hand Myb_DNA-binding PF00249.26 KOO35510.1 - 1.1e-05 25.4 0.6 3.4e-05 23.8 0.1 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain EF-hand_8 PF13833.1 KOO35510.1 - 3.4e-05 23.3 0.0 0.00051 19.5 0.0 2.6 1 1 1 2 2 2 2 EF-hand domain pair Myb_DNA-bind_4 PF13837.1 KOO35510.1 - 0.00038 20.5 0.0 0.0019 18.2 0.0 2.1 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain HHH_8 PF14716.1 KOO35512.1 - 0.0017 18.4 0.3 0.0026 17.8 0.2 1.5 1 1 0 1 1 1 1 Helix-hairpin-helix domain DUF904 PF06005.7 KOO35512.1 - 0.0024 18.1 1.9 0.0029 17.8 1.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF904) DUF2937 PF11157.3 KOO35512.1 - 0.051 12.8 1.4 0.066 12.5 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) Mod_r PF07200.8 KOO35512.1 - 0.15 11.9 2.4 0.2 11.5 1.7 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Med15_fungi PF05397.7 KOO35512.1 - 0.21 11.5 1.9 9.4 6.2 0.1 2.0 1 1 1 2 2 2 0 Mediator complex subunit 15 Baculo_PEP_C PF04513.7 KOO35512.1 - 0.28 10.9 3.0 0.35 10.6 2.1 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus OTU PF02338.14 KOO35513.1 - 0.0005 20.6 0.0 0.00099 19.6 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease EF-hand_1 PF00036.27 KOO35514.1 - 9e-13 46.5 2.4 3.9e-06 25.7 0.2 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO35514.1 - 5.7e-12 45.6 0.1 1.2e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO35514.1 - 1.8e-11 42.9 2.4 5e-05 22.8 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO35514.1 - 5.3e-10 38.7 0.1 8.7e-09 34.8 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO35514.1 - 6.7e-07 28.3 2.6 0.00057 19.1 0.1 2.5 2 0 0 2 2 2 2 EF hand PHY PF00360.15 KOO35514.1 - 0.0024 17.0 0.0 0.0054 15.8 0.0 1.6 1 1 0 1 1 1 1 Phytochrome region SPARC_Ca_bdg PF10591.4 KOO35514.1 - 0.092 12.7 0.0 0.34 10.9 0.0 2.0 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region DUF4365 PF14280.1 KOO35514.1 - 0.099 12.3 0.0 0.41 10.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4365) Rxt3 PF08642.5 KOO35515.1 - 0.00042 20.5 0.0 0.00062 19.9 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylation protein Rxt3 Nup84_Nup100 PF04121.8 KOO35516.1 - 9.1e-38 129.4 0.0 1.4e-28 99.0 0.0 2.6 3 0 0 3 3 3 2 Nuclear pore protein 84 / 107 TIR_2 PF13676.1 KOO35517.1 - 8.1e-12 45.1 0.0 1.2e-11 44.6 0.0 1.2 1 0 0 1 1 1 1 TIR domain TIR PF01582.15 KOO35517.1 - 1e-05 25.0 0.0 1.5e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 TIR domain DUF1863 PF08937.6 KOO35517.1 - 0.00027 20.9 0.1 0.00076 19.5 0.0 1.8 1 1 0 1 1 1 1 MTH538 TIR-like domain (DUF1863) DUF4406 PF14359.1 KOO35517.1 - 0.0005 20.1 0.0 0.00089 19.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4406) MtrF PF09472.5 KOO35517.1 - 0.023 13.9 5.0 0.042 13.0 3.5 1.4 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Thioredoxin_4 PF13462.1 KOO35517.1 - 0.031 14.3 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin AdoHcyase PF05221.12 KOO35518.1 - 6.7e-28 97.3 0.1 7.4e-28 97.2 0.1 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AP2 PF00847.15 KOO35519.1 - 6.8e-06 26.1 0.1 6.8e-06 26.1 0.0 3.3 4 0 0 4 4 4 1 AP2 domain HIG_1_N PF04588.8 KOO35519.1 - 0.14 11.9 0.2 3.4 7.4 0.1 2.5 2 0 0 2 2 2 0 Hypoxia induced protein conserved region CRAL_TRIO PF00650.15 KOO35520.1 - 9.8e-19 67.3 0.0 1.3e-18 66.9 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain E1-N PF14463.1 KOO35520.1 - 0.0015 18.1 0.1 0.0026 17.3 0.0 1.5 1 0 0 1 1 1 1 E1 N-terminal domain SHIPPO-rpt PF07004.7 KOO35521.1 - 7.4e-07 29.7 13.9 0.74 10.8 0.0 5.5 5 0 0 5 5 5 4 Sperm-tail PG-rich repeat CP_ATPgrasp_1 PF04174.8 KOO35523.1 - 0.018 13.6 0.0 0.15 10.6 0.0 1.9 1 1 1 2 2 2 0 A circularly permuted ATPgrasp Neogenin_C PF06583.7 KOO35523.1 - 0.071 12.6 0.0 0.082 12.4 0.0 1.0 1 0 0 1 1 1 0 Neogenin C-terminus TIG PF01833.19 KOO35524.1 - 1e-08 35.0 0.0 1.3e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 IPT/TIG domain TIG PF01833.19 KOO35525.1 - 1.8e-05 24.6 0.7 3.2e-05 23.8 0.1 1.8 2 1 0 2 2 2 1 IPT/TIG domain Methyltransf_16 PF10294.4 KOO35526.1 - 1.3e-16 60.5 0.0 1.8e-14 53.5 0.0 2.2 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.1 KOO35526.1 - 4.2e-09 36.3 0.0 8.5e-09 35.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO35526.1 - 2.1e-07 31.4 0.1 6.5e-07 29.9 0.1 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO35526.1 - 4.6e-06 26.6 0.3 1.4e-05 25.0 0.2 1.9 1 0 0 1 1 1 1 Methyltransferase domain F-box-like PF12937.2 KOO35526.1 - 0.00013 21.6 0.4 0.00027 20.6 0.3 1.6 1 0 0 1 1 1 1 F-box-like MTS PF05175.9 KOO35526.1 - 0.00058 19.2 0.1 0.0012 18.2 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.7 KOO35526.1 - 0.0047 17.3 0.1 0.095 13.1 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO35526.1 - 0.0048 17.3 0.1 0.013 15.9 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 KOO35526.1 - 0.0058 15.7 0.1 0.0096 15.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.1 KOO35526.1 - 0.0099 15.4 0.0 0.025 14.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain tRNA_U5-meth_tr PF05958.6 KOO35526.1 - 0.027 13.1 0.0 0.036 12.7 0.0 1.1 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase TehB PF03848.9 KOO35526.1 - 0.064 12.4 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_32 PF13679.1 KOO35526.1 - 0.072 12.7 0.2 0.78 9.4 0.0 2.6 3 1 1 4 4 4 0 Methyltransferase domain DREV PF05219.7 KOO35526.1 - 0.21 10.4 0.0 0.34 9.7 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Tmemb_cc2 PF10267.4 KOO35526.1 - 0.82 8.1 3.8 1.8 7.0 2.5 1.6 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein F-box PF00646.28 KOO35526.1 - 1.9 8.2 3.9 0.69 9.6 0.6 1.9 2 1 0 2 2 1 0 F-box domain Macoilin PF09726.4 KOO35526.1 - 2.5 6.2 7.4 3.3 5.8 5.1 1.2 1 0 0 1 1 1 0 Transmembrane protein PP-binding PF00550.20 KOO35527.1 - 1.2e-09 38.2 0.1 3.2e-09 36.9 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site SET PF00856.23 KOO35527.1 - 1.5e-05 25.3 5.3 0.078 13.2 0.0 5.5 5 2 1 6 6 6 2 SET domain EGF_2 PF07974.8 KOO35528.1 - 1.8e-18 66.3 75.1 6.2e-05 23.0 10.2 6.4 6 0 0 6 6 6 5 EGF-like domain hEGF PF12661.2 KOO35528.1 - 5.8e-08 32.3 45.7 0.019 15.0 3.4 7.2 6 0 0 6 6 6 4 Human growth factor-like EGF Actin PF00022.14 KOO35528.1 - 7.3e-06 24.6 1.8 0.014 13.8 0.0 3.0 3 0 0 3 3 3 3 Actin Laminin_EGF PF00053.19 KOO35528.1 - 0.018 14.9 68.7 0.82 9.6 0.5 6.4 2 1 4 6 6 6 0 Laminin EGF-like (Domains III and V) PAN_1 PF00024.21 KOO35529.1 - 0.00013 21.6 1.2 0.00025 20.7 0.8 1.4 1 0 0 1 1 1 1 PAN domain Sel1 PF08238.7 KOO35530.1 - 3.6e-98 319.8 93.5 4e-10 40.0 0.6 13.5 14 0 0 14 14 14 12 Sel1 repeat Toxin-JAB1 PF15659.1 KOO35530.1 - 0.00019 21.3 3.4 55 3.5 0.0 8.1 8 2 2 10 10 10 0 JAB-like toxin 1 GSP_synth PF03738.9 KOO35530.1 - 0.00073 19.7 0.9 40 4.5 0.0 4.8 2 1 0 4 4 4 0 Glutathionylspermidine synthase preATP-grasp DUF4135 PF13575.1 KOO35530.1 - 0.046 12.7 4.3 46 2.8 0.0 5.0 4 2 0 5 5 5 0 Domain of unknown function (DUF4135) Guanylate_cyc_2 PF09778.4 KOO35530.1 - 0.1 11.7 0.1 92 2.1 0.0 4.7 3 3 2 6 6 6 0 Guanylylate cyclase Rieske_2 PF13806.1 KOO35530.1 - 0.1 12.3 0.6 38 4.0 0.0 3.6 4 1 1 5 5 5 0 Rieske-like [2Fe-2S] domain WD40 PF00400.27 KOO35531.1 - 2.2e-06 27.3 0.0 1.6e-05 24.5 0.1 2.3 2 0 0 2 2 2 1 WD domain, G-beta repeat HEAT PF02985.17 KOO35531.1 - 3.9e-05 23.3 1.2 0.73 10.0 0.0 4.4 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.1 KOO35531.1 - 0.3 11.3 7.0 5 7.4 1.1 3.9 3 1 1 4 4 4 0 HEAT repeats HEAT_EZ PF13513.1 KOO35531.1 - 0.58 10.7 17.4 0.67 10.5 1.1 5.4 4 2 1 5 5 5 0 HEAT-like repeat DUF2358 PF10184.4 KOO35532.1 - 1.3e-17 63.7 0.0 2.4e-17 62.8 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) SOUL PF04832.7 KOO35532.1 - 6.2e-17 61.6 0.0 8.6e-17 61.2 0.0 1.2 1 0 0 1 1 1 1 SOUL heme-binding protein PsbQ PF05757.6 KOO35533.1 - 0.16 11.3 0.3 0.19 11.1 0.2 1.2 1 0 0 1 1 1 0 Oxygen evolving enhancer protein 3 (PsbQ) Cas6 PF09559.5 KOO35535.1 - 6.5 6.4 6.9 1.1 8.9 2.0 1.8 2 0 0 2 2 2 0 Cas6 Crispr Methyltransf_21 PF05050.7 KOO35536.1 - 0.0047 16.8 0.0 0.012 15.5 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase FkbM domain Ribosomal_L31 PF01197.13 KOO35537.1 - 6e-05 22.9 0.0 6.7e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L31 DUF3035 PF11233.3 KOO35539.1 - 0.2 11.6 2.8 0.25 11.3 1.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3035) Pyridoxal_deC PF00282.14 KOO35541.1 - 5.2e-109 364.1 0.0 1.3e-108 362.7 0.0 1.6 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_1_2 PF00155.16 KOO35541.1 - 0.0097 14.8 0.0 0.022 13.7 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 KOO35541.1 - 0.01 15.0 0.1 0.014 14.5 0.1 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase SLA_LP_auto_ag PF05889.8 KOO35541.1 - 0.23 9.8 0.0 0.36 9.2 0.0 1.2 1 0 0 1 1 1 0 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) IQ PF00612.22 KOO35542.1 - 6.2e-06 25.3 0.7 0.017 14.6 0.1 2.8 2 0 0 2 2 2 2 IQ calmodulin-binding motif DNA_pol_viral_C PF00336.13 KOO35543.1 - 0.001 18.3 0.0 0.0015 17.8 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase (viral) C-terminal domain OTU PF02338.14 KOO35546.1 - 1.3e-06 28.9 0.4 5.5e-06 26.9 0.0 2.1 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 KOO35546.1 - 0.041 13.2 0.1 3 7.1 0.1 2.5 1 1 1 2 2 2 0 Peptidase C65 Otubain ABC1 PF03109.11 KOO35547.1 - 7.2e-25 87.2 0.0 1.1e-24 86.6 0.0 1.3 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 KOO35547.1 - 0.011 15.4 9.8 0.09 12.4 6.8 2.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 KOO35547.1 - 0.26 10.0 0.0 0.36 9.5 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PPR_2 PF13041.1 KOO35548.1 - 4.1e-30 103.5 0.0 1.9e-16 59.7 0.0 2.1 1 1 1 2 2 2 2 PPR repeat family PPR_1 PF12854.2 KOO35548.1 - 1.3e-23 82.1 0.2 6.7e-12 44.6 0.0 3.0 3 0 0 3 3 3 3 PPR repeat PPR PF01535.15 KOO35548.1 - 9.5e-22 75.4 0.0 7.8e-09 34.9 0.0 3.1 3 0 0 3 3 3 3 PPR repeat PPR_3 PF13812.1 KOO35548.1 - 3e-21 73.8 1.7 1.4e-09 37.4 0.0 3.1 3 0 0 3 3 3 3 Pentatricopeptide repeat domain TPR_14 PF13428.1 KOO35548.1 - 0.061 13.9 0.2 0.53 11.0 0.1 2.4 1 1 2 3 3 3 0 Tetratricopeptide repeat MRP-S27 PF10037.4 KOO35548.1 - 0.089 11.7 0.0 0.094 11.6 0.0 1.0 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 Clathrin PF00637.15 KOO35548.1 - 0.13 11.8 0.0 58 3.2 0.0 2.0 1 1 0 1 1 1 0 Region in Clathrin and VPS Bax1-I PF01027.15 KOO35549.1 - 3.6e-36 124.7 21.9 4.5e-36 124.3 15.1 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Aa_trans PF01490.13 KOO35550.1 - 8.5e-55 185.8 17.7 1.1e-54 185.4 12.3 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein TGFb_propeptide PF00688.13 KOO35551.1 - 4.2e-06 26.2 1.4 0.00047 19.5 0.7 2.5 3 0 0 3 3 3 2 TGF-beta propeptide DUF4364 PF14277.1 KOO35552.1 - 0.16 11.5 0.1 0.24 11.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) NAD_binding_10 PF13460.1 KOO35553.1 - 4.3e-30 105.0 0.4 5.6e-30 104.6 0.3 1.1 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 KOO35553.1 - 2.1e-22 79.5 0.0 3.7e-22 78.7 0.0 1.3 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.16 KOO35553.1 - 1.7e-14 53.8 0.1 2.6e-14 53.2 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 KOO35553.1 - 1.9e-08 33.3 0.0 2.7e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 KOO35553.1 - 2.2e-05 24.4 1.6 6.2e-05 22.9 0.8 2.1 2 1 0 2 2 2 1 short chain dehydrogenase NAD_binding_4 PF07993.7 KOO35553.1 - 0.00011 21.2 0.6 0.009 14.9 0.4 2.6 1 1 0 1 1 1 1 Male sterility protein Semialdhyde_dh PF01118.19 KOO35553.1 - 0.00011 22.4 0.1 0.00021 21.5 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 KOO35553.1 - 0.00012 21.1 0.2 0.00016 20.7 0.1 1.1 1 0 0 1 1 1 1 Saccharopine dehydrogenase RmlD_sub_bind PF04321.12 KOO35553.1 - 0.00059 18.8 0.2 0.0015 17.4 0.2 1.6 1 1 0 1 1 1 1 RmlD substrate binding domain TrkA_N PF02254.13 KOO35553.1 - 0.0022 17.9 0.1 0.0042 17.0 0.0 1.6 1 1 0 1 1 1 1 TrkA-N domain F420_oxidored PF03807.12 KOO35553.1 - 0.016 15.6 0.2 0.75 10.2 0.0 2.5 1 1 1 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Ribosomal_L27e PF01777.13 KOO35554.1 - 0.15 12.2 0.0 0.21 11.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomal L27e protein family GRAM PF02893.15 KOO35555.1 - 2.4e-09 36.5 0.0 4.2e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 GRAM domain DUF1162 PF06650.7 KOO35555.1 - 0.081 12.1 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1162) Nucleoside_tran PF01733.13 KOO35556.1 - 2.4e-19 69.6 6.3 3.9e-13 49.2 0.1 3.2 3 0 0 3 3 3 3 Nucleoside transporter Nucleoside_tran PF01733.13 KOO35557.1 - 0.0049 16.0 0.8 0.0055 15.9 0.5 1.0 1 0 0 1 1 1 1 Nucleoside transporter DUF2576 PF10845.3 KOO35557.1 - 0.017 14.2 0.1 0.024 13.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2576) Ank_2 PF12796.2 KOO35558.1 - 5.2e-38 129.2 3.8 1e-13 51.4 0.1 4.5 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO35558.1 - 3.2e-31 105.5 9.8 1e-06 28.2 0.1 5.8 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.1 KOO35558.1 - 1.5e-24 85.4 9.6 1.8e-06 27.9 0.1 5.4 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO35558.1 - 1.2e-23 82.9 6.5 9.4e-08 32.3 0.0 5.0 2 2 4 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO35558.1 - 5.7e-20 69.4 3.1 0.0011 18.9 0.0 5.8 5 0 0 5 5 5 5 Ankyrin repeat DUF2881 PF11087.3 KOO35558.1 - 0.025 14.0 0.0 0.057 12.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2881) Methyltransf_23 PF13489.1 KOO35562.1 - 1.5e-19 70.3 0.0 1.9e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO35562.1 - 4.6e-13 49.4 0.0 7.6e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO35562.1 - 5.6e-09 36.3 0.0 1.3e-08 35.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO35562.1 - 1.6e-07 31.0 0.0 1.4e-06 28.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain DREV PF05219.7 KOO35562.1 - 2.6e-07 29.8 0.0 3.7e-07 29.2 0.0 1.3 1 1 0 1 1 1 1 DREV methyltransferase Methyltransf_18 PF12847.2 KOO35562.1 - 2.8e-05 24.6 0.0 0.001 19.6 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.6 KOO35562.1 - 0.00043 19.0 0.0 0.00054 18.7 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_26 PF13659.1 KOO35562.1 - 0.00082 19.3 0.0 0.0077 16.2 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO35562.1 - 0.002 17.3 0.0 0.058 12.4 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.14 KOO35562.1 - 0.01 15.3 0.0 2.8 7.3 0.0 2.3 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.7 KOO35562.1 - 0.044 13.1 0.0 0.11 11.9 0.0 1.7 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW Aminotran_1_2 PF00155.16 KOO35563.1 - 5.8e-20 71.5 0.0 6.3e-20 71.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II NUDIX PF00293.23 KOO35564.1 - 4.5e-08 32.8 0.0 8.1e-08 31.9 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain Pro_isomerase PF00160.16 KOO35565.1 - 7.9e-44 149.5 0.5 8.8e-44 149.4 0.3 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Topoisom_bac PF01131.15 KOO35566.1 - 4.7e-95 318.7 0.0 5.6e-95 318.5 0.0 1.0 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.17 KOO35566.1 - 7.9e-12 45.0 0.0 1.5e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 Toprim domain Mago_nashi PF02792.9 KOO35567.1 - 2.5e-74 247.7 0.2 3.3e-74 247.3 0.1 1.1 1 0 0 1 1 1 1 Mago nashi protein Hydrolase PF00702.21 KOO35568.1 - 5.1e-11 43.3 0.4 9e-11 42.5 0.3 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOO35568.1 - 1.6e-09 37.5 0.0 1.8e-07 31.0 0.0 2.5 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 KOO35568.1 - 2.8e-06 27.6 0.0 5.4e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 KOO35568.1 - 0.015 14.9 0.0 0.031 13.8 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF4392 PF14336.1 KOO35568.1 - 0.029 13.1 0.5 0.051 12.3 0.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4392) Ycf66_N PF07444.6 KOO35568.1 - 6.2 6.6 9.0 0.91 9.2 1.3 2.6 2 0 0 2 2 2 0 Ycf66 protein N-terminus EF-hand_6 PF13405.1 KOO35569.1 - 6.6e-32 106.5 17.0 1.5e-06 27.5 0.4 7.4 7 0 0 7 7 7 6 EF-hand domain EF-hand_1 PF00036.27 KOO35569.1 - 3.2e-27 91.7 23.9 5.1e-06 25.4 0.4 7.2 7 0 0 7 7 7 6 EF hand EF-hand_7 PF13499.1 KOO35569.1 - 9.7e-26 89.7 15.1 1.1e-08 35.0 0.9 3.9 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO35569.1 - 5.5e-19 67.5 14.3 1.4e-07 30.9 0.0 5.4 5 1 1 6 6 6 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO35569.1 - 1.6e-14 52.4 24.1 0.00037 19.7 0.8 6.6 6 0 0 6 6 6 4 EF hand SPARC_Ca_bdg PF10591.4 KOO35569.1 - 0.00041 20.3 1.4 0.43 10.6 0.0 3.4 2 1 2 4 4 4 3 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.8 KOO35569.1 - 0.0035 17.0 0.4 2.4 7.8 0.1 2.9 2 0 0 2 2 2 2 Tellurite resistance protein TerB EF-hand_9 PF14658.1 KOO35569.1 - 0.0068 16.3 0.1 36 4.3 0.0 4.4 5 0 0 5 5 5 0 EF-hand domain SpaB_C PF14028.1 KOO35569.1 - 0.075 12.5 0.2 0.075 12.5 0.1 2.0 2 1 0 2 2 2 0 SpaB C-terminal domain cNMP_binding PF00027.24 KOO35570.1 - 7.3e-21 73.7 0.1 1.5e-20 72.7 0.1 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Mrr_cat_2 PF13156.1 KOO35570.1 - 0.018 14.9 0.0 0.04 13.8 0.0 1.6 1 0 0 1 1 1 0 Restriction endonuclease Cpn60_TCP1 PF00118.19 KOO35571.1 - 1.3e-12 47.0 0.0 2e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Acyl_transf_3 PF01757.17 KOO35572.1 - 0.0038 16.0 1.2 0.0038 16.0 0.8 1.0 1 0 0 1 1 1 1 Acyltransferase family RseC_MucC PF04246.7 KOO35572.1 - 1.2 8.7 3.7 0.86 9.1 1.5 1.5 1 1 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC E1-E2_ATPase PF00122.15 KOO35573.1 - 3.5e-19 68.7 0.0 4.8e-19 68.2 0.0 1.2 1 0 0 1 1 1 1 E1-E2 ATPase Ycf9 PF01737.12 KOO35573.1 - 0.0022 17.3 0.2 0.007 15.7 0.2 1.8 1 0 0 1 1 1 1 YCF9 CYSTM PF12734.2 KOO35573.1 - 0.022 14.8 6.0 0.05 13.6 4.1 1.6 1 0 0 1 1 1 0 Cysteine-rich TM module stress tolerance Hydrolase PF00702.21 KOO35573.1 - 0.13 12.7 0.0 0.26 11.6 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase AAA PF00004.24 KOO35574.1 - 2.8e-11 43.7 0.0 4.2e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 KOO35574.1 - 1.3e-05 26.0 0.0 2.2e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 KOO35574.1 - 1.4e-05 25.2 0.0 4.8e-05 23.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOO35574.1 - 3.6e-05 23.8 0.0 8.2e-05 22.6 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.7 KOO35574.1 - 3.9e-05 22.8 0.1 7.2e-05 21.9 0.0 1.4 1 1 0 1 1 1 1 Zeta toxin AAA_5 PF07728.9 KOO35574.1 - 0.00016 21.4 0.0 0.00022 20.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.1 KOO35574.1 - 0.00031 20.3 1.6 0.00058 19.4 0.2 1.8 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.1 KOO35574.1 - 0.0011 18.6 0.6 0.0024 17.5 0.1 1.8 1 1 1 2 2 2 1 Part of AAA domain AAA_18 PF13238.1 KOO35574.1 - 0.0012 19.0 0.0 0.0017 18.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 KOO35574.1 - 0.0018 17.3 0.0 0.0022 17.0 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 KOO35574.1 - 0.0034 17.2 0.0 0.0055 16.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 KOO35574.1 - 0.0039 17.1 0.4 0.011 15.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.10 KOO35574.1 - 0.0061 15.2 0.0 0.0082 14.8 0.0 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_14 PF13173.1 KOO35574.1 - 0.0067 16.3 0.0 0.01 15.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 KOO35574.1 - 0.0081 16.3 0.0 0.013 15.6 0.0 1.6 1 1 0 1 1 1 1 RNA helicase AAA_11 PF13086.1 KOO35574.1 - 0.02 14.4 0.0 0.02 14.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 KOO35574.1 - 0.022 13.9 0.0 0.033 13.3 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function, DUF258 AAA_24 PF13479.1 KOO35574.1 - 0.026 14.1 0.0 0.033 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 KOO35574.1 - 0.028 13.5 0.0 0.038 13.1 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.1 KOO35574.1 - 0.029 14.4 0.0 0.089 12.8 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_10 PF12846.2 KOO35574.1 - 0.042 13.2 0.2 1.8 7.9 0.1 2.1 1 1 1 2 2 2 0 AAA-like domain NTPase_1 PF03266.10 KOO35574.1 - 0.064 12.9 0.0 0.18 11.5 0.0 1.8 1 1 1 2 2 2 0 NTPase T2SE PF00437.15 KOO35574.1 - 0.083 11.7 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein DNA_pol3_delta2 PF13177.1 KOO35574.1 - 0.14 11.7 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase III, delta subunit Arch_ATPase PF01637.13 KOO35574.1 - 0.16 11.6 0.0 0.29 10.8 0.0 1.5 1 1 0 1 1 1 0 Archaeal ATPase RFC1 PF08519.7 KOO35575.1 - 2.5e-18 66.2 0.0 3.5e-18 65.8 0.0 1.2 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain Ribosomal_L14e PF01929.12 KOO35576.1 - 1e-23 83.4 2.6 1.3e-23 83.1 1.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.24 KOO35576.1 - 0.00024 20.6 0.0 0.00041 19.9 0.0 1.4 1 0 0 1 1 1 1 KOW motif TIM PF00121.13 KOO35577.1 - 2.8e-68 229.5 0.0 3.4e-68 229.3 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase TPR_12 PF13424.1 KOO35578.1 - 1.4e-08 34.5 1.8 1.4e-07 31.3 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOO35578.1 - 2.4e-06 27.0 2.7 3.6e-06 26.5 0.5 2.0 2 0 0 2 2 2 1 TPR repeat TPR_10 PF13374.1 KOO35578.1 - 4.9e-06 26.2 0.1 0.19 11.7 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO35578.1 - 5.6e-06 25.8 7.3 0.01 15.6 0.1 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO35578.1 - 1.9e-05 24.1 0.1 1.3 8.9 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO35578.1 - 0.0003 20.2 5.7 0.003 17.1 0.2 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO35578.1 - 0.00057 20.1 0.1 0.99 9.7 0.2 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO35578.1 - 0.012 16.1 0.6 5 8.0 0.3 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1897 PF09005.5 KOO35578.1 - 0.17 11.3 3.8 0.12 11.8 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1897) TPR_8 PF13181.1 KOO35578.1 - 0.19 11.5 2.0 1.2 9.0 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.1 KOO35578.1 - 5.2 7.8 7.1 6.6 7.5 0.1 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.27 KOO35579.1 - 4.3e-63 207.1 22.0 1.4e-12 46.9 0.6 5.2 5 0 0 5 5 5 5 WD domain, G-beta repeat PD40 PF07676.7 KOO35579.1 - 1e-12 47.4 0.5 0.75 9.5 0.0 5.3 5 0 0 5 5 5 5 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOO35579.1 - 2.2e-06 27.5 0.7 0.0015 18.2 0.0 2.9 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A DUF3312 PF11768.3 KOO35579.1 - 0.00025 19.3 0.0 0.72 8.0 0.0 3.3 1 1 3 4 4 4 3 Protein of unknown function (DUF3312) Nbas_N PF15492.1 KOO35579.1 - 0.00028 20.0 4.8 3.8 6.5 0.1 4.4 2 1 3 5 5 5 4 Neuroblastoma-amplified sequence, N terminal TFIIIC_delta PF12657.2 KOO35579.1 - 0.0042 16.8 4.2 0.13 11.9 0.4 3.8 2 1 1 3 3 3 2 Transcription factor IIIC subunit delta N-term Dfp1_Him1_M PF08630.5 KOO35579.1 - 0.014 15.1 4.9 18 5.1 0.0 4.3 5 0 0 5 5 5 0 Dfp1/Him1, central region Proteasome_A_N PF10584.4 KOO35579.1 - 6.4 6.1 11.6 1.5e+02 1.7 0.1 5.3 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature ubiquitin PF00240.18 KOO35580.1 - 2.1e-16 59.0 0.0 2.3e-10 39.7 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.3 KOO35580.1 - 2.4e-06 27.1 0.0 0.00068 19.2 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 KOO35580.1 - 0.0014 18.8 0.0 0.037 14.2 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin-like domain DUF3234 PF11572.3 KOO35580.1 - 0.035 14.2 0.0 0.12 12.5 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3234) Myb_DNA-binding PF00249.26 KOO35582.1 - 5.7e-18 64.7 1.2 1.3e-09 37.9 0.1 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO35582.1 - 2.6e-11 43.4 0.2 8e-06 25.8 0.1 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_5 PF13873.1 KOO35582.1 - 1.2e-05 25.0 1.0 0.034 14.0 0.0 2.6 2 0 0 2 2 2 2 Myb/SANT-like DNA-binding domain zf-C2H2_4 PF13894.1 KOO35582.1 - 0.12 12.7 5.7 4.7 7.7 2.1 3.2 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 KOO35582.1 - 2.6 8.5 4.2 22 5.6 0.1 3.5 3 0 0 3 3 3 0 Zinc finger, C2H2 type PDZ PF00595.19 KOO35585.1 - 6.2e-23 80.7 1.2 9e-07 28.9 0.0 3.5 3 0 0 3 3 3 3 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO35585.1 - 7.9e-21 73.7 0.4 1.7e-06 27.7 0.0 3.4 3 0 0 3 3 3 3 PDZ domain Tricorn_PDZ PF14685.1 KOO35585.1 - 0.00016 21.3 0.4 1.3 8.8 0.0 3.3 3 0 0 3 3 3 2 Tricorn protease PDZ domain Kinetochor_Ybp2 PF08568.5 KOO35586.1 - 2.4e-09 36.0 0.0 3.7e-09 35.4 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin K-box PF01486.12 KOO35587.1 - 0.0026 17.4 0.7 0.0038 16.9 0.5 1.2 1 0 0 1 1 1 1 K-box region Apolipoprotein PF01442.13 KOO35588.1 - 0.0057 16.1 2.7 0.014 14.8 1.8 1.6 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain Cytochrom_B562 PF07361.6 KOO35588.1 - 0.012 16.0 0.1 0.018 15.4 0.1 1.5 1 1 0 1 1 1 0 Cytochrome b562 DUF162 PF02589.10 KOO35588.1 - 0.018 14.5 0.1 0.021 14.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised ACR, YkgG family COG1556 Erp_C PF06780.6 KOO35588.1 - 0.079 12.7 0.2 0.09 12.6 0.2 1.1 1 0 0 1 1 1 0 Erp protein C-terminus TRCF PF03461.10 KOO35588.1 - 0.088 12.7 0.4 0.41 10.6 0.1 1.9 2 0 0 2 2 2 0 TRCF domain DUF4398 PF14346.1 KOO35588.1 - 0.094 12.7 1.0 0.11 12.5 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4398) PilO PF04350.8 KOO35588.1 - 0.098 12.5 0.2 0.15 11.9 0.1 1.5 1 1 0 1 1 1 0 Pilus assembly protein, PilO WEMBL PF05701.6 KOO35588.1 - 0.12 10.8 2.0 0.14 10.6 1.4 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light Syntaxin PF00804.20 KOO35588.1 - 0.12 12.5 0.6 0.54 10.4 0.4 1.9 1 1 0 1 1 1 0 Syntaxin WXG100 PF06013.7 KOO35588.1 - 0.12 12.4 1.0 2 8.4 0.1 2.3 1 1 1 2 2 2 0 Proteins of 100 residues with WXG PAS_3 PF08447.6 KOO35588.1 - 0.12 12.4 0.1 1.7 8.7 0.0 2.0 2 0 0 2 2 2 0 PAS fold HSCB_C PF07743.8 KOO35588.1 - 0.19 12.1 2.5 0.47 10.9 0.5 2.0 1 1 2 3 3 3 0 HSCB C-terminal oligomerisation domain Latarcin PF10279.4 KOO35588.1 - 0.22 11.7 3.2 0.47 10.6 0.7 2.2 1 1 1 2 2 2 0 Latarcin precursor DinB_2 PF12867.2 KOO35588.1 - 0.29 11.4 1.6 4.9 7.5 0.2 2.2 1 1 1 2 2 2 0 DinB superfamily DUF883 PF05957.8 KOO35588.1 - 0.32 11.4 1.9 0.84 10.0 0.4 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Exonuc_VII_S PF02609.11 KOO35588.1 - 0.82 9.4 4.6 4.3 7.1 0.3 2.8 2 1 0 2 2 2 0 Exonuclease VII small subunit Na_H_antiport_2 PF13726.1 KOO35589.1 - 0.13 12.1 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Na+-H+ antiporter family RabGAP-TBC PF00566.13 KOO35590.1 - 3.2e-40 137.8 0.0 6.3e-40 136.9 0.0 1.5 1 1 0 1 1 1 1 Rab-GTPase-TBC domain KIAA1430 PF13879.1 KOO35591.1 - 3.4e-05 24.2 9.3 0.0018 18.6 4.7 2.5 1 1 1 3 3 3 2 KIAA1430 homologue DUF3138 PF11336.3 KOO35591.1 - 0.0032 15.7 9.2 0.0032 15.7 6.4 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3138) NatB_MDM20 PF09797.4 KOO35591.1 - 0.011 14.4 0.1 0.014 14.1 0.1 1.2 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit FlaC_arch PF05377.6 KOO35591.1 - 0.014 15.2 2.4 3.6 7.5 0.1 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) RcbX PF02341.10 KOO35591.1 - 0.024 14.7 0.9 0.043 13.9 0.6 1.4 1 0 0 1 1 1 0 RbcX protein DivIC PF04977.10 KOO35591.1 - 0.41 10.1 19.9 0.23 10.9 1.3 3.7 2 1 2 4 4 4 0 Septum formation initiator bZIP_1 PF00170.16 KOO35591.1 - 1.4 8.9 23.0 0.25 11.3 0.6 4.5 4 1 0 4 4 4 0 bZIP transcription factor NYD-SP28_assoc PF14775.1 KOO35591.1 - 4.7 6.9 7.3 11 5.7 0.5 2.8 3 0 0 3 3 3 0 Sperm tail C-terminal domain KIAA1430 PF13879.1 KOO35592.1 - 0.082 13.3 0.1 0.1 13.0 0.0 1.1 1 0 0 1 1 1 0 KIAA1430 homologue PUL PF08324.6 KOO35592.1 - 0.092 11.5 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 PUL domain HDV_ag PF01517.13 KOO35592.1 - 0.11 12.1 0.9 0.14 11.7 0.3 1.4 1 1 0 1 1 1 0 Hepatitis delta virus delta antigen IncA PF04156.9 KOO35592.1 - 0.3 10.6 2.3 0.34 10.4 1.6 1.0 1 0 0 1 1 1 0 IncA protein Sigma70_ner PF04546.8 KOO35592.1 - 0.35 10.4 4.6 0.43 10.1 3.2 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region PBP1_TM PF14812.1 KOO35592.1 - 0.96 9.7 5.6 1.2 9.4 3.9 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PBP1_TM PF14812.1 KOO35593.1 - 0.00026 21.2 1.1 0.00077 19.7 0.1 2.1 2 0 0 2 2 2 1 Transmembrane domain of transglycosylase PBP1 at N-terminal TLP-20 PF06088.6 KOO35593.1 - 0.035 13.7 0.4 0.07 12.7 0.3 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Nop14 PF04147.7 KOO35593.1 - 0.65 7.8 5.2 0.78 7.5 3.6 1.2 1 0 0 1 1 1 0 Nop14-like family PurS PF02700.9 KOO35594.1 - 0.3 11.0 3.8 0.16 11.9 0.5 2.2 2 1 0 2 2 2 0 Phosphoribosylformylglycinamidine (FGAM) synthase BID PF06393.6 KOO35594.1 - 0.58 9.4 4.3 1 8.6 0.5 2.1 2 0 0 2 2 2 0 BH3 interacting domain (BID) Gag_p15 PF08723.5 KOO35594.1 - 0.7 9.9 3.2 0.34 10.9 0.2 1.9 2 0 0 2 2 2 0 Gag protein p15 MbeB_N PF04837.7 KOO35594.1 - 2.3 8.3 7.5 11 6.2 0.1 2.9 2 1 1 3 3 3 0 MbeB-like, N-term conserved region ADH_zinc_N PF00107.21 KOO35596.1 - 0.1 12.1 0.1 1 8.9 0.2 2.0 2 0 0 2 2 2 0 Zinc-binding dehydrogenase O-FucT PF10250.4 KOO35597.1 - 8e-11 41.6 0.1 1.7e-07 30.6 0.0 2.1 1 1 1 2 2 2 2 GDP-fucose protein O-fucosyltransferase DUF3746 PF12562.3 KOO35597.1 - 0.17 11.7 0.3 10 6.0 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3746) Cation_efflux PF01545.16 KOO35598.1 - 1.3e-58 198.3 1.4 1.7e-58 198.0 1.0 1.1 1 0 0 1 1 1 1 Cation efflux family Zip PF02535.17 KOO35598.1 - 5.5 5.8 42.0 0.35 9.8 15.4 2.5 2 1 1 3 3 3 0 ZIP Zinc transporter EF-hand_1 PF00036.27 KOO35599.1 - 1.4e-16 58.4 0.1 0.0017 17.5 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO35599.1 - 4.6e-16 57.2 0.3 0.0068 16.2 0.0 4.8 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO35599.1 - 6e-14 51.9 0.9 4.9e-07 29.7 0.0 3.4 2 1 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO35599.1 - 1.3e-12 47.0 1.1 0.00039 19.9 0.0 3.8 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO35599.1 - 5.1e-10 38.2 0.3 0.082 12.2 0.1 4.4 4 1 1 5 5 5 3 EF hand Guanylate_cyc PF00211.15 KOO35599.1 - 0.0009 18.6 0.0 0.25 10.7 0.0 2.8 2 1 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain EF-hand_4 PF12763.2 KOO35599.1 - 0.0025 17.4 0.1 0.015 15.0 0.0 2.2 3 0 0 3 3 3 1 Cytoskeletal-regulatory complex EF hand GTP_EFTU PF00009.22 KOO35600.1 - 1e-48 165.2 0.0 1.6e-48 164.6 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOO35600.1 - 4.7e-05 23.3 0.0 8.2e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.20 KOO35600.1 - 6.2e-05 23.0 0.0 0.00017 21.5 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.1 KOO35600.1 - 0.0012 18.6 0.0 0.0023 17.7 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II SRPRB PF09439.5 KOO35600.1 - 0.15 11.2 0.1 0.77 8.9 0.0 2.1 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit WD40 PF00400.27 KOO35601.1 - 9.2e-14 50.7 1.2 2e-05 24.2 0.3 5.2 5 1 0 5 5 5 3 WD domain, G-beta repeat RRM_6 PF14259.1 KOO35602.1 - 3.8e-22 78.0 0.0 3.5e-10 39.7 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOO35602.1 - 2.2e-15 56.0 0.0 2.3e-08 33.5 0.0 2.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO35602.1 - 4.5e-07 29.6 0.0 0.0042 16.9 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 KOO35602.1 - 0.038 13.8 0.0 3.1 7.7 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif CS PF04969.11 KOO35603.1 - 0.00089 19.7 0.0 0.0016 18.9 0.0 1.3 1 0 0 1 1 1 1 CS domain RRM_6 PF14259.1 KOO35606.1 - 2.1e-07 30.7 0.0 3.1e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOO35606.1 - 0.0048 16.4 0.0 0.0071 15.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIS_M PF07500.9 KOO35607.1 - 4.6e-10 39.5 0.2 6.4e-10 39.1 0.2 1.2 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain Zn-ribbon_8 PF09723.5 KOO35607.1 - 0.47 10.4 3.4 1.2 9.1 0.1 2.4 2 0 0 2 2 2 0 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.2 KOO35607.1 - 0.81 9.5 6.2 1.4 8.7 0.6 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain TFIIS_C PF01096.13 KOO35607.1 - 1 9.0 4.8 12 5.5 0.2 2.3 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Lar_restr_allev PF14354.1 KOO35607.1 - 2.3 8.6 6.8 7.1 7.0 4.2 2.1 1 1 1 2 2 2 0 Restriction alleviation protein Lar AAA PF00004.24 KOO35611.1 - 7.4e-21 74.7 0.0 1.3e-20 73.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO35611.1 - 5.2e-06 26.5 0.0 2.2e-05 24.5 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 KOO35611.1 - 3.3e-05 24.6 0.0 6.9e-05 23.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.9 KOO35611.1 - 6.1e-05 22.7 0.0 0.00012 21.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.8 KOO35611.1 - 0.00012 21.1 0.0 0.00014 20.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ABC_tran PF00005.22 KOO35611.1 - 0.00022 21.5 0.0 0.00045 20.5 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA_22 PF13401.1 KOO35611.1 - 0.00067 19.8 0.0 0.0019 18.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 KOO35611.1 - 0.0012 18.2 0.0 0.0039 16.6 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.1 KOO35611.1 - 0.0029 17.5 0.0 0.0073 16.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 KOO35611.1 - 0.004 16.2 0.0 0.0072 15.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Arch_ATPase PF01637.13 KOO35611.1 - 0.0049 16.5 0.0 0.0097 15.6 0.0 1.5 1 0 0 1 1 1 1 Archaeal ATPase AAA_11 PF13086.1 KOO35611.1 - 0.006 16.1 0.0 0.012 15.1 0.0 1.4 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 KOO35611.1 - 0.011 14.9 0.0 0.024 13.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_33 PF13671.1 KOO35611.1 - 0.011 15.6 0.0 0.025 14.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 KOO35611.1 - 0.014 15.5 0.0 0.029 14.5 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Rad17 PF03215.10 KOO35611.1 - 0.015 14.0 0.0 0.021 13.5 0.0 1.1 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein NACHT PF05729.7 KOO35611.1 - 0.019 14.6 0.0 0.16 11.6 0.0 2.1 1 1 1 2 2 2 0 NACHT domain AAA_29 PF13555.1 KOO35611.1 - 0.019 14.5 0.0 0.037 13.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Viral_helicase1 PF01443.13 KOO35611.1 - 0.02 14.3 0.0 0.038 13.5 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Zeta_toxin PF06414.7 KOO35611.1 - 0.03 13.4 0.0 0.071 12.1 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.1 KOO35611.1 - 0.032 14.1 0.0 0.055 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 KOO35611.1 - 0.04 13.6 0.0 0.079 12.7 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain AAA_18 PF13238.1 KOO35611.1 - 0.045 14.0 0.0 0.092 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 KOO35611.1 - 0.065 13.1 0.0 0.23 11.4 0.0 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase Herpes_Helicase PF02689.9 KOO35611.1 - 0.069 10.8 0.0 0.1 10.2 0.0 1.2 1 0 0 1 1 1 0 Helicase AAA_24 PF13479.1 KOO35611.1 - 0.069 12.7 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.16 KOO35611.1 - 0.072 12.2 0.0 0.18 10.9 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_23 PF13476.1 KOO35611.1 - 0.079 13.2 0.0 0.18 12.0 0.0 1.5 2 0 0 2 2 1 0 AAA domain PPV_E1_C PF00519.12 KOO35611.1 - 0.097 11.2 0.0 0.24 9.9 0.0 1.6 1 1 1 2 2 2 0 Papillomavirus helicase KaiC PF06745.8 KOO35611.1 - 0.1 11.6 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 KaiC Adeno_IVa2 PF02456.10 KOO35611.1 - 0.11 11.1 0.0 0.25 9.9 0.0 1.6 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_10 PF12846.2 KOO35611.1 - 0.11 11.8 0.1 1.2 8.5 0.0 2.4 3 0 0 3 3 3 0 AAA-like domain AAA_21 PF13304.1 KOO35611.1 - 0.12 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain PseudoU_synth_2 PF00849.17 KOO35612.1 - 6.7e-25 87.8 0.1 9.6e-25 87.3 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase Ion_trans PF00520.26 KOO35613.1 - 1.4e-08 34.2 4.6 2e-08 33.7 3.2 1.2 1 0 0 1 1 1 1 Ion transport protein CBM_6 PF03422.10 KOO35613.1 - 0.02 15.0 0.0 0.072 13.2 0.0 1.9 2 1 0 2 2 2 0 Carbohydrate binding module (family 6) PKD_channel PF08016.7 KOO35613.1 - 0.19 10.1 10.9 0.037 12.4 0.8 2.1 2 0 0 2 2 2 0 Polycystin cation channel MORN PF02493.15 KOO35614.1 - 1e-09 37.5 0.1 9.1e-05 21.9 0.0 2.7 2 0 0 2 2 2 2 MORN repeat C2 PF00168.25 KOO35615.1 - 1.1e-06 28.4 0.0 5.7e-06 26.0 0.0 2.1 2 0 0 2 2 2 1 C2 domain DAGK_acc PF00609.14 KOO35616.1 - 1.1e-13 51.6 0.0 1.9e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain TAF4 PF05236.9 KOO35618.1 - 5.7 6.1 7.9 1.1 8.5 2.6 1.8 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family DAGK_cat PF00781.19 KOO35619.1 - 8.6e-28 96.3 0.0 1.7e-27 95.3 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain DAGK_acc PF00609.14 KOO35619.1 - 7e-26 91.2 0.0 2e-23 83.2 0.0 2.3 2 0 0 2 2 2 2 Diacylglycerol kinase accessory domain C2 PF00168.25 KOO35620.1 - 0.15 11.9 0.0 1.1 9.1 0.0 2.2 3 0 0 3 3 3 0 C2 domain bZIP_1 PF00170.16 KOO35622.1 - 0.033 14.1 0.9 0.033 14.1 0.7 4.1 4 1 1 5 5 5 0 bZIP transcription factor Reo_sigmaC PF04582.7 KOO35622.1 - 0.15 11.2 5.7 0.33 10.0 3.3 1.8 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Bacillus_HBL PF05791.6 KOO35622.1 - 0.3 10.4 10.8 0.21 10.9 0.4 2.8 1 1 2 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) GAS PF13851.1 KOO35622.1 - 0.78 8.8 25.6 0.28 10.3 10.8 2.3 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding TRAM_LAG1_CLN8 PF03798.11 KOO35623.1 - 3.8e-13 49.4 9.3 5.4e-13 48.9 6.4 1.3 1 0 0 1 1 1 1 TLC domain Tropomyosin PF00261.15 KOO35624.1 - 0.041 12.9 2.3 0.34 9.9 0.8 2.0 2 0 0 2 2 2 0 Tropomyosin MAD PF05557.8 KOO35624.1 - 0.046 11.8 1.6 0.069 11.2 1.1 1.2 1 0 0 1 1 1 0 Mitotic checkpoint protein DUF465 PF04325.8 KOO35624.1 - 0.051 13.2 3.2 1.6 8.4 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF465) MscS_porin PF12795.2 KOO35624.1 - 0.076 12.3 5.0 1.2 8.4 2.0 2.1 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain CCDC-167 PF15188.1 KOO35624.1 - 0.094 12.6 3.3 1.1 9.3 0.3 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 Fez1 PF06818.10 KOO35624.1 - 0.099 12.6 7.2 0.29 11.1 5.0 1.7 1 1 0 1 1 1 0 Fez1 GAS PF13851.1 KOO35624.1 - 0.11 11.6 0.6 5.7 6.0 0.1 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Flagellin_C PF00700.16 KOO35624.1 - 0.19 11.8 2.2 0.89 9.7 0.3 2.5 2 1 0 2 2 2 0 Bacterial flagellin C-terminal helical region Nup54 PF13874.1 KOO35624.1 - 0.67 9.6 3.8 0.28 10.8 0.8 1.7 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 HrpB7 PF09486.5 KOO35624.1 - 8 6.3 21.0 0.8 9.6 9.1 2.9 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) DUF221 PF02714.10 KOO35626.1 - 6.3e-06 25.2 12.4 0.0011 17.9 1.5 2.7 3 0 0 3 3 3 2 Domain of unknown function DUF221 Corona_S2 PF01601.11 KOO35626.1 - 2.2 6.3 5.3 4.3 5.3 3.7 1.4 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein HAD PF12710.2 KOO35632.1 - 6.2e-10 39.5 0.0 3.3e-09 37.1 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOO35632.1 - 2.1e-09 38.1 2.6 2.1e-05 25.0 0.0 2.3 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 KOO35632.1 - 2.8e-08 33.5 0.0 7.2e-08 32.2 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 KOO35632.1 - 0.022 14.3 0.1 0.044 13.3 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 KOO35632.1 - 0.039 14.1 0.2 0.48 10.6 0.0 2.7 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase MerR-DNA-bind PF09278.6 KOO35632.1 - 0.099 13.0 1.7 0.37 11.2 1.0 2.1 2 0 0 2 2 2 0 MerR, DNA binding Peptidase_M1 PF01433.15 KOO35633.1 - 4.9e-74 249.7 0.0 6.3e-74 249.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 Leuk-A4-hydro_C PF09127.6 KOO35633.1 - 3.4e-36 123.9 0.0 5.7e-36 123.2 0.0 1.4 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_MA_2 PF13485.1 KOO35633.1 - 1.2e-12 48.0 0.0 4.1e-12 46.2 0.0 2.0 2 0 0 2 2 2 1 Peptidase MA superfamily Mto2_bdg PF12808.2 KOO35634.1 - 0.2 11.7 13.0 0.085 12.9 0.4 3.1 3 0 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region ERG4_ERG24 PF01222.12 KOO35635.1 - 3.8e-130 434.2 4.2 4.5e-130 434.0 2.9 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 KOO35635.1 - 0.0044 16.3 0.4 0.011 15.0 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) DUF1388 PF07142.7 KOO35635.1 - 0.036 13.7 10.2 0.029 14.0 4.2 2.5 1 1 1 2 2 2 0 Repeat of unknown function (DUF1388) FAP PF07174.6 KOO35635.1 - 7.5 5.7 15.7 12 5.0 10.9 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Lactamase_B PF00753.22 KOO35636.1 - 7.9e-28 97.4 3.5 1.1e-27 97.0 2.4 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 KOO35636.1 - 0.0073 15.8 0.1 0.0095 15.4 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain cNMP_binding PF00027.24 KOO35637.1 - 1.2e-14 53.8 0.0 4.8e-09 35.9 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain LRR_6 PF13516.1 KOO35638.1 - 2.8e-52 168.8 5.7 0.00022 20.9 0.0 10.4 10 0 0 10 10 10 10 Leucine Rich repeat LRR_4 PF12799.2 KOO35638.1 - 2.7e-08 33.2 4.2 0.44 10.2 0.0 6.9 3 3 4 8 8 8 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO35638.1 - 8.8e-08 31.1 0.0 28 5.2 0.0 8.5 10 0 0 10 10 10 0 Leucine Rich Repeat LRR_7 PF13504.1 KOO35638.1 - 4e-05 23.1 2.4 97 3.8 0.0 8.0 9 0 0 9 9 9 0 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO35638.1 - 0.032 14.4 7.1 6.2 7.0 0.1 4.8 4 1 0 4 4 4 0 RNA 2'-O ribose methyltransferase substrate binding CbiG_N PF11760.3 KOO35638.1 - 0.36 10.5 31.5 18 5.1 0.1 8.2 2 2 7 9 9 9 0 Cobalamin synthesis G N-terminal DUF2202 PF09968.4 KOO35638.1 - 2 8.0 7.0 81 2.8 0.0 5.1 1 1 7 8 8 8 0 Uncharacterized protein domain (DUF2202) Methyltransf_16 PF10294.4 KOO35639.1 - 2.5e-16 59.6 0.0 2.5e-10 40.1 0.0 2.3 2 0 0 2 2 2 2 Putative methyltransferase tRNA_m1G_MT PF01746.16 KOO35639.1 - 1.9e-13 50.4 0.0 3e-13 49.7 0.0 1.2 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase MTS PF05175.9 KOO35639.1 - 0.022 14.1 0.2 0.044 13.1 0.2 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_18 PF12847.2 KOO35639.1 - 0.053 14.0 0.2 0.23 12.0 0.1 2.2 2 0 0 2 2 2 0 Methyltransferase domain IQ PF00612.22 KOO35640.1 - 0.0018 17.7 13.3 0.21 11.3 1.7 3.9 3 0 0 3 3 3 2 IQ calmodulin-binding motif Pkinase PF00069.20 KOO35641.1 - 3.5e-55 186.9 0.0 5.2e-55 186.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO35641.1 - 2.7e-33 115.1 0.0 3.8e-33 114.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Ank PF00023.25 KOO35641.1 - 5.8e-17 60.5 2.8 6e-09 35.2 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.2 KOO35641.1 - 2.8e-15 56.4 1.6 5.9e-15 55.3 0.0 2.3 2 1 1 3 3 3 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO35641.1 - 2.2e-14 53.1 2.0 1.7e-08 34.3 0.1 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO35641.1 - 4.4e-14 51.1 0.2 3.7e-06 26.6 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 KOO35641.1 - 1.3e-09 38.3 0.0 3.3e-09 37.0 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Kinase-like PF14531.1 KOO35641.1 - 0.0023 16.9 0.0 0.0073 15.3 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 KOO35641.1 - 0.014 14.4 0.0 0.028 13.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 KOO35641.1 - 0.39 9.5 0.1 0.58 8.9 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 DUF938 PF06080.7 KOO35642.1 - 1.1e-46 159.0 0.0 1.3e-45 155.5 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_23 PF13489.1 KOO35642.1 - 0.0021 17.7 0.0 0.0041 16.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO35642.1 - 0.11 13.0 0.2 4.2 7.8 0.0 3.3 3 1 0 3 3 3 0 Methyltransferase domain EF-hand_8 PF13833.1 KOO35643.1 - 0.0029 17.2 0.0 0.0082 15.7 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO35643.1 - 0.0036 16.4 0.0 0.012 14.8 0.0 2.0 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.1 KOO35643.1 - 0.0086 16.2 0.0 0.035 14.2 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO35643.1 - 0.034 13.4 0.0 0.11 11.8 0.0 2.0 1 0 0 1 1 1 0 EF hand DUF1840 PF08895.6 KOO35643.1 - 0.091 12.7 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) PQQ_3 PF13570.1 KOO35643.1 - 0.17 12.2 8.4 1.1 9.6 0.1 4.0 5 0 0 5 5 5 0 PQQ-like domain EF-hand_6 PF13405.1 KOO35643.1 - 0.27 11.2 1.7 0.76 9.8 0.1 2.7 2 0 0 2 2 2 0 EF-hand domain NHL PF01436.16 KOO35644.1 - 1.7e-37 125.4 18.9 6.6e-07 28.9 0.1 6.5 6 0 0 6 6 6 6 NHL repeat SGL PF08450.7 KOO35644.1 - 2.2e-22 79.6 16.0 0.00072 19.0 0.3 6.1 1 1 5 6 6 6 6 SMP-30/Gluconolaconase/LRE-like region BTB PF00651.26 KOO35644.1 - 4.6e-21 74.8 0.4 7.7e-21 74.1 0.1 1.5 2 0 0 2 2 2 1 BTB/POZ domain DUF839 PF05787.8 KOO35644.1 - 1.5e-07 30.7 3.5 0.52 9.1 0.0 4.4 1 1 4 5 5 5 4 Bacterial protein of unknown function (DUF839) P_proprotein PF01483.15 KOO35644.1 - 2.1e-05 24.2 0.0 9.2 6.1 0.0 4.8 5 0 0 5 5 5 2 Proprotein convertase P-domain Tcp10_C PF07202.8 KOO35644.1 - 0.00015 21.3 0.0 0.19 11.2 0.0 3.4 3 0 0 3 3 3 1 T-complex protein 10 C-terminus WG_beta_rep PF14903.1 KOO35644.1 - 0.0016 18.6 4.2 8.7 6.7 0.0 5.4 6 0 0 6 6 6 1 WG containing repeat IN_DBD_C PF00552.16 KOO35644.1 - 0.011 15.1 0.0 2.6 7.5 0.0 4.0 5 0 0 5 5 5 0 Integrase DNA binding domain DUF3342 PF11822.3 KOO35644.1 - 0.015 14.4 0.0 0.06 12.4 0.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3342) LTXXQ PF07813.7 KOO35645.1 - 0.23 11.9 0.0 0.23 11.9 0.0 3.2 3 1 1 4 4 4 0 LTXXQ motif family protein Acyltransferase PF01553.16 KOO35646.1 - 7.9e-21 73.8 0.0 1e-20 73.4 0.0 1.1 1 0 0 1 1 1 1 Acyltransferase DUF809 PF05663.6 KOO35646.1 - 0.17 11.8 0.1 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF809) ECH PF00378.15 KOO35647.1 - 2e-30 105.7 0.0 1.9e-28 99.2 0.0 2.1 1 1 0 2 2 2 2 Enoyl-CoA hydratase/isomerase family ECH_C PF13766.1 KOO35647.1 - 2.6e-20 72.7 0.1 5.9e-20 71.5 0.0 1.6 2 0 0 2 2 2 1 2-enoyl-CoA Hydratase C-terminal region NPV_P10 PF05531.7 KOO35648.1 - 0.012 15.8 10.3 0.028 14.6 0.0 3.4 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.7 KOO35648.1 - 0.039 13.7 2.5 0.49 10.2 0.0 2.7 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus PAP_central PF04928.12 KOO35648.1 - 0.86 8.3 7.5 2.9 6.6 5.3 2.0 1 1 0 1 1 1 0 Poly(A) polymerase central domain Snapin_Pallidin PF14712.1 KOO35648.1 - 0.95 9.8 22.3 0.38 11.1 1.4 3.7 1 1 3 4 4 4 0 Snapin/Pallidin DUF342 PF03961.8 KOO35648.1 - 2.4 6.4 25.5 0.43 8.9 6.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF342) PspA_IM30 PF04012.7 KOO35648.1 - 2.8 7.2 36.9 2.8 7.2 0.7 3.2 1 1 1 2 2 2 0 PspA/IM30 family IncA PF04156.9 KOO35648.1 - 3.5 7.1 27.8 5.3 6.6 6.5 3.0 1 1 1 2 2 2 0 IncA protein ADIP PF11559.3 KOO35648.1 - 4.8 7.0 29.5 0.39 10.6 1.9 3.2 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Phyto_Pns9_10 PF05878.6 KOO35648.1 - 6.4 5.6 12.7 18 4.2 8.6 1.9 1 1 0 1 1 1 0 Phytoreovirus nonstructural protein Pns9/Pns10 APG6 PF04111.7 KOO35648.1 - 9.7 5.1 31.5 7.3 5.5 9.1 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 R3H PF01424.17 KOO35649.1 - 7.7e-15 54.3 0.0 1.2e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 R3H domain G-patch PF01585.18 KOO35649.1 - 6.9e-08 32.1 3.5 1.4e-07 31.1 2.4 1.6 1 1 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 KOO35649.1 - 0.00099 18.9 0.7 0.002 17.9 0.5 1.6 1 0 0 1 1 1 1 DExH-box splicing factor binding site Mononeg_RNA_pol PF00946.14 KOO35649.1 - 0.045 11.1 0.0 0.065 10.6 0.0 1.2 1 0 0 1 1 1 0 Mononegavirales RNA dependent RNA polymerase DUF1694 PF07997.6 KOO35649.1 - 0.067 13.1 0.0 0.095 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1694) EF-hand_1 PF00036.27 KOO35650.1 - 4.7e-21 72.4 0.3 3.8e-06 25.7 0.0 4.5 4 1 1 5 5 5 3 EF hand EF-hand_6 PF13405.1 KOO35650.1 - 1.5e-17 61.8 1.1 6.2e-05 22.5 0.0 4.9 4 1 1 5 5 5 3 EF-hand domain EF-hand_7 PF13499.1 KOO35650.1 - 1.9e-16 59.9 0.0 3.3e-09 36.7 0.0 3.0 1 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO35650.1 - 3.2e-16 57.8 0.4 2.5e-06 26.5 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.1 KOO35650.1 - 4.9e-16 58.0 0.5 5.3e-09 35.5 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_10 PF14788.1 KOO35650.1 - 0.17 11.6 0.3 4.5 7.0 0.0 3.1 4 0 0 4 4 4 0 EF hand TPR_4 PF07721.9 KOO35652.1 - 0.37 11.3 3.0 0.81 10.3 0.3 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat SET PF00856.23 KOO35653.1 - 4e-18 66.2 4.2 5.8e-09 36.4 0.1 3.2 3 1 0 3 3 3 2 SET domain SAF PF08666.7 KOO35653.1 - 0.025 14.9 0.0 3.4 8.1 0.0 3.0 2 0 0 2 2 2 0 SAF domain DUF3228 PF11539.3 KOO35654.1 - 2.1e-77 258.6 0.0 2.4e-77 258.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3228) zf-CCCH PF00642.19 KOO35656.1 - 7.7e-06 25.4 3.4 1.5e-05 24.4 2.4 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) F-box-like PF12937.2 KOO35656.1 - 0.0032 17.1 0.4 0.0064 16.1 0.3 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 KOO35656.1 - 0.0047 16.5 0.0 0.0083 15.7 0.0 1.3 1 0 0 1 1 1 1 F-box domain zf-CCCH_2 PF14608.1 KOO35656.1 - 0.33 11.0 3.8 0.65 10.0 2.6 1.5 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type Ank_2 PF12796.2 KOO35658.1 - 9.3e-22 77.1 6.2 2.4e-08 34.2 0.0 3.6 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) ADPrib_exo_Tox PF03496.9 KOO35658.1 - 4.6e-18 65.1 0.0 1.4e-09 37.4 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosyltransferase exoenzyme Ank_5 PF13857.1 KOO35658.1 - 2.4e-16 59.3 4.9 3.1e-06 27.2 0.6 4.1 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO35658.1 - 9e-16 56.8 8.5 5.6e-05 22.7 0.1 6.6 6 0 0 6 6 6 3 Ankyrin repeat ART PF01129.13 KOO35658.1 - 1.1e-13 50.8 0.0 5.4e-06 25.6 0.0 2.6 3 0 0 3 3 3 2 NAD:arginine ADP-ribosyltransferase Ank_4 PF13637.1 KOO35658.1 - 1.1e-13 51.2 1.1 2.2e-06 27.9 0.1 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO35658.1 - 2e-09 36.7 3.9 0.0051 16.9 0.0 5.5 6 0 0 6 6 6 2 Ankyrin repeat SUI1 PF01253.17 KOO35658.1 - 0.0016 18.2 0.3 2.6 7.9 0.0 2.4 2 0 0 2 2 2 2 Translation initiation factor SUI1 Dus PF01207.12 KOO35659.1 - 6.5e-13 48.1 0.0 7.6e-13 47.9 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Clp1 PF06807.9 KOO35660.1 - 1.1e-30 106.9 0.0 1.5e-30 106.4 0.0 1.2 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 MobB PF03205.9 KOO35660.1 - 1.2e-10 41.2 0.0 4.2e-10 39.4 0.0 1.9 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 KOO35660.1 - 0.00086 19.3 0.0 0.0021 18.0 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain CbiA PF01656.18 KOO35660.1 - 0.017 14.5 0.0 0.028 13.8 0.0 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_17 PF13207.1 KOO35660.1 - 0.018 15.8 0.0 0.029 15.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF2475 PF10629.4 KOO35661.1 - 5.1e-30 103.5 17.1 7.1e-08 32.5 0.2 5.5 5 0 0 5 5 5 5 Protein of unknown function (DUF2475) Glyco_trans_1_4 PF13692.1 KOO35662.1 - 2.7e-05 24.3 0.5 0.00014 22.0 0.1 2.2 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.15 KOO35662.1 - 0.00026 20.4 0.0 0.00049 19.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Sec63 PF02889.11 KOO35663.1 - 0.0024 17.1 0.0 0.0081 15.4 0.0 1.8 1 1 1 2 2 2 1 Sec63 Brl domain PCI PF01399.22 KOO35664.1 - 1.3e-12 47.9 0.0 3.7e-12 46.4 0.0 1.8 1 0 0 1 1 1 1 PCI domain HTH_Tnp_4 PF13613.1 KOO35664.1 - 0.11 12.1 0.0 0.35 10.4 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix of DDE superfamily endonuclease FliP PF00813.15 KOO35664.1 - 0.16 11.6 0.2 0.3 10.7 0.1 1.4 1 0 0 1 1 1 0 FliP family ABC2_membrane PF01061.19 KOO35665.1 - 1.9e-34 118.6 9.5 1.9e-34 118.6 6.6 2.1 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.22 KOO35665.1 - 5.3e-23 81.8 0.0 8e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.2 KOO35665.1 - 2.6e-07 30.0 6.3 5.5e-07 28.9 4.4 1.5 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_16 PF13191.1 KOO35665.1 - 0.00011 22.2 0.6 0.00022 21.2 0.4 1.4 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 KOO35665.1 - 0.00023 20.3 0.3 0.00039 19.6 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_21 PF13304.1 KOO35665.1 - 0.00036 20.5 0.0 0.098 12.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 KOO35665.1 - 0.0018 17.7 0.1 0.018 14.4 0.1 2.1 2 0 0 2 2 2 1 AAA-like domain Arch_ATPase PF01637.13 KOO35665.1 - 0.002 17.8 0.1 0.0034 17.1 0.0 1.2 1 0 0 1 1 1 1 Archaeal ATPase AAA_19 PF13245.1 KOO35665.1 - 0.0052 16.5 0.2 0.015 15.0 0.1 1.9 1 1 0 1 1 1 1 Part of AAA domain AAA_17 PF13207.1 KOO35665.1 - 0.0079 17.0 0.0 0.018 15.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 KOO35665.1 - 0.011 15.3 0.0 0.019 14.5 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.1 KOO35665.1 - 0.011 15.8 0.0 0.033 14.3 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_25 PF13481.1 KOO35665.1 - 0.014 14.7 0.0 0.082 12.2 0.1 2.0 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 KOO35665.1 - 0.023 14.3 0.0 0.043 13.5 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.1 KOO35665.1 - 0.043 13.3 0.0 0.069 12.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 KOO35665.1 - 0.044 13.7 0.0 0.073 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 KOO35665.1 - 0.047 13.2 0.2 0.1 12.1 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.1 KOO35665.1 - 0.049 13.9 0.1 0.094 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.14 KOO35665.1 - 0.05 12.8 0.1 1.6 7.8 0.1 2.1 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA PF00004.24 KOO35665.1 - 0.066 13.4 0.0 0.16 12.1 0.0 1.6 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) ABC2_membrane_2 PF12679.2 KOO35665.1 - 0.077 11.8 5.0 0.048 12.5 2.2 1.5 2 0 0 2 2 2 0 ABC-2 family transporter protein MMR_HSR1 PF01926.18 KOO35665.1 - 0.092 12.7 0.2 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF87 PF01935.12 KOO35665.1 - 0.097 12.4 0.1 0.15 11.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF87 SbcCD_C PF13558.1 KOO35665.1 - 0.12 12.3 0.1 1 9.3 0.1 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit UPF0079 PF02367.12 KOO35665.1 - 0.14 11.7 0.1 0.41 10.2 0.1 1.8 2 0 0 2 2 1 0 Uncharacterised P-loop hydrolase UPF0079 cobW PF02492.14 KOO35665.1 - 0.15 11.5 0.0 0.29 10.5 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.1 KOO35665.1 - 0.25 11.6 0.3 0.42 10.9 0.2 1.2 1 0 0 1 1 1 0 AAA domain WBS_methylT PF12589.3 KOO35666.1 - 6.9e-16 58.5 7.1 1.1e-15 57.8 4.9 1.4 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.7 KOO35666.1 - 4.1e-14 52.8 0.0 7.8e-14 51.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO35666.1 - 2.1e-07 30.6 0.0 3.2e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO35666.1 - 3.3e-06 27.5 0.0 7.6e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO35666.1 - 3.8e-06 27.2 0.0 8.3e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO35666.1 - 1.9e-05 25.1 0.0 3.5e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO35666.1 - 8.5e-05 22.3 0.0 0.00013 21.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO35666.1 - 0.00016 21.6 0.0 0.00037 20.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO35666.1 - 0.0031 16.6 0.0 0.0064 15.6 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family AdoMet_MTase PF07757.8 KOO35666.1 - 0.0044 17.1 0.0 0.0093 16.0 0.0 1.6 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase MetW PF07021.7 KOO35666.1 - 0.048 13.0 0.0 0.069 12.5 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW CMAS PF02353.15 KOO35666.1 - 0.061 12.3 0.0 0.088 11.8 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase N6_N4_Mtase PF01555.13 KOO35666.1 - 0.07 12.6 0.0 0.99 8.8 0.0 2.1 2 0 0 2 2 2 0 DNA methylase UQ_con PF00179.21 KOO35667.1 - 4.3e-43 146.1 0.0 5.2e-43 145.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 KOO35667.1 - 0.0001 22.1 0.0 0.00017 21.4 0.0 1.5 1 1 0 1 1 1 1 RWD domain UEV PF05743.8 KOO35667.1 - 0.013 15.1 0.0 0.022 14.4 0.0 1.4 1 1 0 1 1 1 0 UEV domain DUF3972 PF13118.1 KOO35668.1 - 0.031 14.3 3.6 0.069 13.2 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3972) Kinesin PF00225.18 KOO35669.1 - 7.7e-81 271.3 0.0 1.4e-50 171.9 0.2 2.1 1 1 1 2 2 2 2 Kinesin motor domain End3 PF12761.2 KOO35669.1 - 0.033 13.8 0.4 4.2 6.9 0.2 2.4 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 PIF1 PF05970.9 KOO35669.1 - 0.18 10.7 0.0 0.26 10.1 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase Heme_oxygenase PF01126.15 KOO35671.1 - 5.7e-15 55.4 0.0 8.8e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 Heme oxygenase LRR_5 PF13306.1 KOO35672.1 - 2.3e-67 224.5 0.1 2.9e-37 127.2 0.0 2.3 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO35672.1 - 3.5e-23 81.1 0.0 9.9e-05 22.0 0.0 5.7 2 1 6 8 8 8 7 Leucine rich repeat Skp1 PF01466.14 KOO35672.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Skp1 family, dimerisation domain Fork_head_N PF08430.7 KOO35672.1 - 0.83 10.0 10.2 6.8 7.0 3.2 2.6 1 1 1 2 2 2 0 Forkhead N-terminal region HemY_N PF07219.8 KOO35673.1 - 0.17 11.4 1.5 0.3 10.6 1.1 1.5 1 0 0 1 1 1 0 HemY protein N-terminus DnaJ PF00226.26 KOO35674.1 - 5.3e-27 93.3 1.5 8.2e-27 92.7 1.0 1.3 1 0 0 1 1 1 1 DnaJ domain EF-hand_6 PF13405.1 KOO35674.1 - 9.8e-08 31.2 0.0 0.0075 16.0 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO35674.1 - 5.2e-07 29.6 0.0 2.6e-05 24.2 0.0 2.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO35674.1 - 7.9e-06 24.8 0.0 0.054 12.8 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO35674.1 - 0.00057 19.4 0.0 1.1 8.8 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EFhand_Ca_insen PF08726.5 KOO35674.1 - 0.0013 18.7 0.0 1.2 9.2 0.0 2.7 2 0 0 2 2 2 2 Ca2+ insensitive EF hand EF-hand_5 PF13202.1 KOO35674.1 - 0.0058 15.9 0.0 1.9 7.9 0.0 2.7 2 0 0 2 2 2 2 EF hand Glyco_transf_25 PF01755.12 KOO35675.1 - 0.17 11.5 0.0 0.57 9.7 0.0 1.7 1 1 1 2 2 2 0 Glycosyltransferase family 25 (LPS biosynthesis protein) Rubis-subs-bind PF09273.6 KOO35676.1 - 1.3e-12 47.7 0.5 7.2e-12 45.3 0.0 2.0 2 0 0 2 2 2 1 Rubisco LSMT substrate-binding SET PF00856.23 KOO35676.1 - 0.00011 22.5 0.0 0.0022 18.3 0.0 2.4 1 1 0 1 1 1 1 SET domain LRR_6 PF13516.1 KOO35677.1 - 2.1e-32 107.4 0.0 0.00015 21.4 0.0 7.0 7 0 0 7 7 7 6 Leucine Rich repeat LRR_4 PF12799.2 KOO35677.1 - 8.5e-09 34.8 0.0 0.043 13.4 0.0 5.1 4 1 1 5 5 5 2 Leucine Rich repeats (2 copies) SpoU_sub_bind PF08032.7 KOO35677.1 - 5e-08 33.0 1.0 0.46 10.6 0.0 4.7 3 1 1 4 4 4 2 RNA 2'-O ribose methyltransferase substrate binding LRR_1 PF00560.28 KOO35677.1 - 6.1e-06 25.5 0.0 38 4.8 0.0 5.9 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_7 PF13504.1 KOO35677.1 - 7e-06 25.4 0.6 38 5.1 0.1 6.1 6 0 0 6 6 6 0 Leucine rich repeat LRR_8 PF13855.1 KOO35677.1 - 0.00029 20.5 0.5 3.4 7.5 0.1 4.6 1 1 4 5 5 5 2 Leucine rich repeat CbiG_N PF11760.3 KOO35677.1 - 0.021 14.5 9.1 1.7 8.3 0.3 4.1 4 1 1 5 5 5 0 Cobalamin synthesis G N-terminal PARP PF00644.15 KOO35677.1 - 0.091 12.1 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain HTH_3 PF01381.17 KOO35677.1 - 0.1 12.4 0.9 1.4 8.8 0.1 2.9 3 0 0 3 3 3 0 Helix-turn-helix DUF552 PF04472.7 KOO35677.1 - 0.13 12.2 0.0 2.8 7.9 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF552) DUF2202 PF09968.4 KOO35677.1 - 0.28 10.8 1.9 35 4.0 0.1 3.7 1 1 3 4 4 4 0 Uncharacterized protein domain (DUF2202) Drf_DAD PF06345.6 KOO35677.1 - 0.28 11.0 1.9 22 5.1 0.1 2.7 2 0 0 2 2 2 0 DRF Autoregulatory Domain Pkinase PF00069.20 KOO35680.1 - 5.8e-68 228.8 0.0 7.5e-68 228.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO35680.1 - 3e-31 108.4 0.0 4.4e-31 107.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO35680.1 - 0.00019 20.5 0.3 0.00034 19.7 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 KOO35680.1 - 0.012 14.9 0.5 0.022 14.1 0.4 1.3 1 0 0 1 1 1 0 RIO1 family cNMP_binding PF00027.24 KOO35681.1 - 0.03 14.1 0.0 0.057 13.2 0.0 1.4 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain TraH PF06122.6 KOO35682.1 - 0.039 12.7 0.2 0.068 11.9 0.2 1.3 1 0 0 1 1 1 0 Conjugative relaxosome accessory transposon protein ANTAR PF03861.9 KOO35682.1 - 0.11 12.1 2.3 1 9.0 0.6 2.5 2 1 0 2 2 2 0 ANTAR domain HsbA PF12296.3 KOO35682.1 - 0.17 11.7 1.4 1 9.2 0.1 2.1 2 0 0 2 2 2 0 Hydrophobic surface binding protein A ThylakoidFormat PF11264.3 KOO35683.1 - 9.5e-20 71.1 0.0 2.6e-19 69.7 0.0 1.7 1 1 0 1 1 1 1 Thylakoid formation protein Med2 PF11214.3 KOO35683.1 - 0.65 10.0 5.5 1.1 9.2 3.8 1.3 1 0 0 1 1 1 0 Mediator complex subunit 2 NAD_binding_8 PF13450.1 KOO35684.1 - 8.3e-07 28.9 0.0 1.7e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 KOO35684.1 - 0.00054 19.1 0.0 0.025 13.6 0.0 2.1 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Fer2 PF00111.22 KOO35685.1 - 4.3e-12 45.6 0.5 5.5e-12 45.2 0.3 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain SH3BP5 PF05276.9 KOO35686.1 - 3.2e-05 23.3 19.7 0.00035 19.9 3.9 2.2 1 1 1 2 2 2 2 SH3 domain-binding protein 5 (SH3BP5) DUF1192 PF06698.6 KOO35686.1 - 0.039 13.7 0.7 0.039 13.7 0.5 3.7 2 2 1 3 3 3 0 Protein of unknown function (DUF1192) Peptidase_S46 PF10459.4 KOO35686.1 - 1.7 6.9 14.8 2.3 6.5 10.2 1.1 1 0 0 1 1 1 0 Peptidase S46 RHD3 PF05879.7 KOO35686.1 - 2.7 5.7 8.6 0.53 8.1 1.8 1.8 1 1 0 2 2 2 0 Root hair defective 3 GTP-binding protein (RHD3) IncA PF04156.9 KOO35686.1 - 4.9 6.7 18.7 2.9 7.4 3.9 2.2 2 0 0 2 2 2 0 IncA protein ATP-synt_B PF00430.13 KOO35686.1 - 6.3 6.6 31.5 0.61 9.8 3.2 2.9 1 1 2 3 3 3 0 ATP synthase B/B' CF(0) Alpha_kinase PF02816.13 KOO35687.1 - 2.2e-20 73.1 0.0 1.3e-19 70.5 0.0 2.1 1 1 0 1 1 1 1 Alpha-kinase family VWA_2 PF13519.1 KOO35687.1 - 5e-09 36.5 0.1 1.6e-08 34.8 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain CcmD PF04995.9 KOO35688.1 - 0.081 12.6 1.1 0.14 11.9 0.3 1.7 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) CoA_trans PF01144.18 KOO35690.1 - 9.8e-107 355.0 2.3 1.1e-67 227.3 0.3 2.0 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.1 KOO35690.1 - 0.0028 17.3 0.0 0.005 16.5 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain Peptidase_U9 PF03420.8 KOO35691.1 - 0.034 13.4 0.0 0.053 12.7 0.0 1.2 1 0 0 1 1 1 0 Prohead core protein protease PABP PF00658.13 KOO35692.1 - 3.4e-08 33.0 0.0 8.7e-08 31.7 0.0 1.7 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain OTU PF02338.14 KOO35692.1 - 6e-06 26.8 0.0 1e-05 26.0 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease HTH_psq PF05225.11 KOO35695.1 - 0.13 11.7 0.2 0.58 9.7 0.1 2.0 2 0 0 2 2 2 0 helix-turn-helix, Psq domain zinc_ribbon_2 PF13240.1 KOO35696.1 - 0.0021 17.4 0.1 0.0031 16.9 0.1 1.3 1 0 0 1 1 1 1 zinc-ribbon domain zf-ribbon_3 PF13248.1 KOO35696.1 - 0.088 12.0 0.1 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 zinc-ribbon domain Peptidase_S8 PF00082.17 KOO35697.1 - 5.3e-30 104.5 5.9 5.3e-30 104.5 4.1 3.1 2 1 0 2 2 2 1 Subtilase family P_proprotein PF01483.15 KOO35697.1 - 3.5e-08 33.1 0.0 1.8e-07 30.8 0.0 2.1 2 0 0 2 2 2 1 Proprotein convertase P-domain Arm PF00514.18 KOO35698.1 - 1e-100 326.5 57.9 5.6e-09 35.5 0.3 13.0 13 0 0 13 13 13 13 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 KOO35698.1 - 2e-17 63.1 11.2 3e-05 23.2 0.1 6.1 1 1 6 7 7 7 7 Armadillo-like RPAP1_C PF08620.5 KOO35698.1 - 5.1e-17 61.4 1.3 10 6.0 0.0 12.5 13 0 0 13 13 13 0 RPAP1-like, C-terminal DNA_ligase_OB PF03120.11 KOO35698.1 - 6e-12 45.0 9.2 4.8 6.9 0.0 10.3 5 4 5 10 10 10 1 NAD-dependent DNA ligase OB-fold domain HEAT_EZ PF13513.1 KOO35698.1 - 1.1e-08 35.3 46.0 0.008 16.6 0.7 8.5 4 2 6 10 10 10 8 HEAT-like repeat KAP PF05804.7 KOO35698.1 - 3.7e-06 25.1 0.0 0.17 9.7 0.0 3.5 1 1 2 4 4 4 2 Kinesin-associated protein (KAP) HEAT PF02985.17 KOO35698.1 - 1.7e-05 24.4 10.4 24 5.3 0.0 10.1 13 0 0 13 13 12 0 HEAT repeat Peptidase_S41 PF03572.13 KOO35698.1 - 4e-05 23.0 6.0 8.6 5.7 0.0 7.0 4 3 1 5 5 5 1 Peptidase family S41 HEAT_2 PF13646.1 KOO35698.1 - 7.2e-05 22.9 49.9 0.021 15.0 2.9 6.2 1 1 5 7 7 7 5 HEAT repeats Atx10homo_assoc PF09759.4 KOO35698.1 - 0.00016 21.3 1.8 0.33 10.6 0.0 4.7 5 0 0 5 5 5 1 Spinocerebellar ataxia type 10 protein domain ACC_central PF08326.7 KOO35698.1 - 0.00042 18.5 1.6 33 2.4 0.0 6.8 2 2 10 12 12 12 0 Acetyl-CoA carboxylase, central region SPOUT_MTase PF02590.12 KOO35698.1 - 0.00053 19.7 21.0 2.7 7.7 0.2 6.9 1 1 5 8 8 8 1 Predicted SPOUT methyltransferase DUF383 PF04063.9 KOO35698.1 - 0.0015 18.1 0.0 0.4 10.2 0.0 4.0 1 1 0 1 1 1 1 Domain of unknown function (DUF383) DUF805 PF05656.9 KOO35698.1 - 0.004 16.9 0.2 65 3.3 0.0 6.2 4 3 0 4 4 4 0 Protein of unknown function (DUF805) Mg-por_mtran_C PF07109.6 KOO35698.1 - 0.0073 16.3 10.5 34 4.5 0.1 7.7 8 2 2 10 10 10 0 Magnesium-protoporphyrin IX methyltransferase C-terminus DUF1676 PF07898.8 KOO35698.1 - 0.03 14.6 1.9 2.7e+02 1.9 0.0 6.5 3 3 7 10 10 10 0 Protein of unknown function (DUF1676) DUF2046 PF09755.4 KOO35699.1 - 6.2e-23 81.1 19.4 6.2e-23 81.1 13.5 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein H4 (DUF2046) CENP-F_leu_zip PF10473.4 KOO35699.1 - 0.0061 16.4 5.0 0.0061 16.4 3.5 3.7 2 1 1 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 NRDE PF05742.7 KOO35699.1 - 0.22 10.8 6.4 0.17 11.1 3.2 1.7 2 1 0 2 2 2 0 NRDE protein MetW PF07021.7 KOO35699.1 - 0.4 10.0 2.6 0.65 9.3 1.8 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW YiiD_Cterm PF09500.5 KOO35699.1 - 0.86 9.1 3.7 20 4.7 0.6 2.5 2 0 0 2 2 2 0 Putative thioesterase (yiiD_Cterm) APG6 PF04111.7 KOO35699.1 - 1.8 7.5 36.1 1.5 7.8 16.2 2.2 2 0 0 2 2 2 0 Autophagy protein Apg6 Prominin PF05478.6 KOO35699.1 - 8.3 3.8 11.8 13 3.1 8.2 1.2 1 0 0 1 1 1 0 Prominin UPRTase PF14681.1 KOO35700.1 - 3.3e-69 232.2 0.0 4.4e-69 231.8 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 KOO35700.1 - 4.7e-05 23.1 0.0 7.6e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PTR2 PF00854.16 KOO35702.1 - 5.9e-48 163.5 0.3 5.2e-38 130.7 0.5 2.6 1 1 1 2 2 2 2 POT family MFS_1 PF07690.11 KOO35702.1 - 2.3e-09 36.4 17.7 2.9e-09 36.0 12.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Adaptin_N PF01602.15 KOO35705.1 - 6.7e-81 272.1 0.9 9.2e-81 271.7 0.6 1.1 1 0 0 1 1 1 1 Adaptin N terminal region AD PF09793.4 KOO35705.1 - 9.8e-11 41.3 0.0 2e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain Cnd1 PF12717.2 KOO35705.1 - 3.5e-07 30.2 0.2 8.9e-06 25.6 0.0 2.7 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 KOO35705.1 - 1.1e-06 28.7 1.0 0.0017 18.5 0.1 4.3 2 2 2 4 4 4 2 HEAT repeats HEAT PF02985.17 KOO35705.1 - 0.009 16.0 1.1 4.5 7.6 0.0 4.4 4 0 0 4 4 4 1 HEAT repeat DUF2454 PF10521.4 KOO35705.1 - 0.024 13.6 0.0 0.058 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2454) Cnd3 PF12719.2 KOO35705.1 - 0.057 12.3 2.1 0.96 8.3 0.0 2.7 3 0 0 3 3 3 0 Nuclear condensing complex subunits, C-term domain ParcG PF10274.4 KOO35705.1 - 0.14 12.0 2.9 0.63 9.9 0.0 3.1 3 1 0 4 4 4 0 Parkin co-regulated protein SAP PF02037.22 KOO35707.1 - 1.5e-11 43.5 0.2 1.7e-11 43.3 0.1 1.1 1 0 0 1 1 1 1 SAP domain HeH PF12949.2 KOO35707.1 - 0.035 13.6 0.1 0.22 11.0 0.1 2.0 1 1 0 1 1 1 0 HeH/LEM domain Pkinase PF00069.20 KOO35708.1 - 1.2e-69 234.3 0.0 1.7e-69 233.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO35708.1 - 1.7e-33 115.8 0.0 2.2e-33 115.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO35708.1 - 0.00029 19.8 0.1 0.0006 18.8 0.0 1.6 1 1 0 1 1 1 1 Kinase-like FeoB_N PF02421.13 KOO35708.1 - 0.023 13.9 0.3 0.16 11.2 0.2 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B APH PF01636.18 KOO35708.1 - 0.04 13.6 0.0 0.34 10.6 0.1 2.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family TraG_N PF07916.6 KOO35709.1 - 0.12 10.7 0.0 0.13 10.6 0.0 1.0 1 0 0 1 1 1 0 TraG-like protein, N-terminal region Guanylate_cyc PF00211.15 KOO35710.1 - 5.2e-09 35.7 0.0 9e-09 34.9 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Ion_trans PF00520.26 KOO35710.1 - 7.9e-06 25.2 1.6 7.9e-06 25.2 1.1 2.4 3 0 0 3 3 3 1 Ion transport protein HemY_N PF07219.8 KOO35710.1 - 0.22 11.0 1.7 0.77 9.3 0.0 2.7 3 0 0 3 3 3 0 HemY protein N-terminus Pro_isomerase PF00160.16 KOO35711.1 - 4.9e-44 150.2 0.1 5.4e-44 150.1 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD MatE PF01554.13 KOO35712.1 - 1.1e-27 96.6 23.7 1.2e-16 60.7 3.6 2.9 3 0 0 3 3 3 2 MatE DUF2499 PF10693.4 KOO35712.1 - 0.069 13.1 1.8 0.11 12.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2499) Pkinase_Tyr PF07714.12 KOO35713.1 - 9.2e-25 87.1 0.1 1.3e-24 86.6 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.20 KOO35713.1 - 1.3e-23 83.5 0.1 2e-23 82.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Methyltransf_32 PF13679.1 KOO35714.1 - 1.3e-13 50.8 0.0 2.7e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO35714.1 - 0.01 15.4 0.0 0.016 14.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain TFCD_C PF12612.3 KOO35715.1 - 9.9e-20 70.7 0.5 2.1e-19 69.7 0.3 1.5 1 0 0 1 1 1 1 Tubulin folding cofactor D C terminal HEAT_EZ PF13513.1 KOO35715.1 - 2.9e-05 24.4 41.8 0.064 13.7 0.0 9.4 7 3 3 10 10 10 6 HEAT-like repeat HEAT_2 PF13646.1 KOO35715.1 - 0.00082 19.6 5.8 0.0064 16.7 0.3 6.6 5 2 3 8 8 8 2 HEAT repeats Vac14_Fab1_bd PF12755.2 KOO35715.1 - 0.11 12.9 0.0 3 8.2 0.0 3.2 3 1 1 4 4 4 0 Vacuolar 14 Fab1-binding region HEAT PF02985.17 KOO35715.1 - 0.19 11.8 0.0 0.19 11.8 0.0 5.9 7 0 0 7 7 7 0 HEAT repeat NYN PF01936.13 KOO35716.1 - 1.9e-19 70.4 0.0 3.1e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 NYN domain PhoPQ_related PF10142.4 KOO35717.1 - 1.3e-89 300.2 0.0 1.6e-89 299.9 0.0 1.1 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein Abhydrolase_5 PF12695.2 KOO35717.1 - 2.7e-08 33.7 0.0 1.1e-07 31.6 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family DNA_pol_A_exo1 PF01612.15 KOO35718.1 - 4.7e-05 22.9 0.1 0.11 12.0 0.0 2.1 2 0 0 2 2 2 2 3'-5' exonuclease PhoPQ_related PF10142.4 KOO35720.1 - 2.5e-63 213.7 0.0 2.9e-63 213.5 0.0 1.0 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein zf-CDGSH PF09360.5 KOO35721.1 - 2.3e-08 33.7 2.0 4.1e-08 32.9 1.4 1.4 1 0 0 1 1 1 1 Iron-binding zinc finger CDGSH type Redoxin PF08534.5 KOO35721.1 - 0.067 12.7 0.1 0.067 12.7 0.1 1.1 1 0 0 1 1 1 0 Redoxin tRNA_U5-meth_tr PF05958.6 KOO35722.1 - 5.2e-83 278.6 0.0 7.6e-57 192.5 0.0 2.1 2 0 0 2 2 2 2 tRNA (Uracil-5-)-methyltransferase RrnaAD PF00398.15 KOO35722.1 - 1.7e-05 24.0 0.0 2.6e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_26 PF13659.1 KOO35722.1 - 2.5e-05 24.3 4.3 2.5e-05 24.3 3.0 3.0 2 2 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO35722.1 - 0.00015 22.2 0.5 0.00091 19.7 0.1 2.5 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_4 PF02390.12 KOO35722.1 - 0.0002 20.4 0.0 0.00032 19.8 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Cons_hypoth95 PF03602.10 KOO35722.1 - 0.00065 19.1 0.1 0.016 14.6 0.1 2.3 2 0 0 2 2 2 1 Conserved hypothetical protein 95 Methyltransf_15 PF09445.5 KOO35722.1 - 0.0037 16.8 0.0 0.0083 15.6 0.0 1.7 1 1 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MTS PF05175.9 KOO35722.1 - 0.0065 15.8 0.4 0.015 14.6 0.3 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 KOO35722.1 - 0.019 15.2 1.6 0.091 13.1 0.0 2.6 3 0 0 3 3 2 0 Methyltransferase domain CHAT PF12770.2 KOO35722.1 - 0.023 13.8 1.0 0.074 12.1 0.0 2.1 2 1 0 2 2 2 0 CHAT domain Methyltransf_31 PF13847.1 KOO35722.1 - 0.029 13.9 0.0 0.23 11.0 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Thioredoxin PF00085.15 KOO35723.1 - 5e-25 87.1 0.3 9.4e-25 86.3 0.2 1.4 1 0 0 1 1 1 1 Thioredoxin PPR PF01535.15 KOO35723.1 - 3.9e-08 32.7 4.0 1.3 9.1 0.0 5.3 5 0 0 5 5 5 3 PPR repeat Thioredoxin_7 PF13899.1 KOO35723.1 - 1.2e-07 31.6 0.1 3.4e-07 30.1 0.1 1.8 1 0 0 1 1 1 1 Thioredoxin-like PPR_3 PF13812.1 KOO35723.1 - 6.9e-07 29.0 25.2 0.45 10.9 0.5 7.7 7 0 0 7 7 7 3 Pentatricopeptide repeat domain Thioredoxin_8 PF13905.1 KOO35723.1 - 0.00014 21.9 0.0 0.00036 20.6 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 KOO35723.1 - 0.00039 20.5 0.3 0.0026 17.9 0.1 2.4 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_9 PF14595.1 KOO35723.1 - 0.0031 17.0 0.1 0.011 15.2 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin Redoxin PF08534.5 KOO35723.1 - 0.0067 15.9 0.2 0.021 14.3 0.0 1.8 2 0 0 2 2 2 1 Redoxin PPR_2 PF13041.1 KOO35723.1 - 0.0073 16.2 0.6 11 6.1 0.0 4.7 5 2 1 6 6 6 1 PPR repeat family Glutaredoxin PF00462.19 KOO35723.1 - 0.017 15.0 0.0 0.05 13.5 0.0 1.8 1 0 0 1 1 1 0 Glutaredoxin AhpC-TSA PF00578.16 KOO35723.1 - 0.066 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family DUF4611 PF15387.1 KOO35724.1 - 0.013 15.6 3.3 0.019 15.1 2.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Nucleoplasmin PF03066.10 KOO35724.1 - 0.083 12.3 5.9 0.11 12.0 4.1 1.3 1 0 0 1 1 1 0 Nucleoplasmin Sigma70_ner PF04546.8 KOO35724.1 - 0.85 9.2 6.3 1 8.9 4.3 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region CENP-B_dimeris PF09026.5 KOO35724.1 - 2.4 8.4 12.7 3.5 7.9 8.8 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Ax_dynein_light PF10211.4 KOO35729.1 - 4.6e-05 23.3 1.3 4.6e-05 23.3 0.9 3.1 2 1 1 3 3 3 1 Axonemal dynein light chain MIase PF02426.11 KOO35729.1 - 0.019 14.7 0.0 3.1 7.6 0.0 2.8 2 1 0 2 2 2 0 Muconolactone delta-isomerase Cep57_CLD PF14073.1 KOO35729.1 - 0.63 9.8 17.4 2.6 7.8 3.8 2.3 2 0 0 2 2 2 0 Centrosome localisation domain of Cep57 KLRAQ PF10205.4 KOO35729.1 - 0.77 9.8 8.6 5 7.2 0.1 3.2 3 0 0 3 3 3 0 Predicted coiled-coil domain-containing protein Lebercilin PF15619.1 KOO35729.1 - 0.81 9.0 16.6 0.21 10.9 3.3 3.2 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease CENP-F_leu_zip PF10473.4 KOO35729.1 - 0.9 9.3 20.1 3.5 7.4 4.6 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4618 PF15397.1 KOO35729.1 - 2.1 7.6 8.6 4.8 6.4 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) Seryl_tRNA_N PF02403.17 KOO35729.1 - 2.2 8.3 9.7 5.3 7.1 1.7 2.9 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain APG6 PF04111.7 KOO35729.1 - 3.4 6.6 10.2 3.1 6.7 1.5 2.2 2 0 0 2 2 2 0 Autophagy protein Apg6 GRP PF07172.6 KOO35729.1 - 3.5 8.1 25.2 0.048 14.1 12.3 1.7 2 0 0 2 2 1 0 Glycine rich protein family GAS PF13851.1 KOO35729.1 - 4.3 6.4 12.5 0.25 10.5 1.7 2.4 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Ank_2 PF12796.2 KOO35730.1 - 6.4e-61 202.6 32.9 1e-15 57.7 0.8 5.8 1 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank PF00023.25 KOO35730.1 - 4e-41 136.8 43.6 7.9e-07 28.5 0.2 11.5 11 0 0 11 11 11 10 Ankyrin repeat Ank_4 PF13637.1 KOO35730.1 - 1.2e-35 121.2 17.5 9.2e-08 32.4 0.1 7.6 4 3 5 9 9 9 7 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO35730.1 - 3.7e-33 112.7 34.8 1.2e-06 28.5 0.2 9.9 1 1 9 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO35730.1 - 9.2e-20 68.7 19.8 0.00016 21.5 0.0 10.1 10 0 0 10 10 10 5 Ankyrin repeat DUF4182 PF13790.1 KOO35730.1 - 1.4e-05 24.7 5.3 0.17 11.7 0.0 5.6 7 0 0 7 7 7 1 Domain of unknown function (DUF4182) Peptidase_S49_N PF08496.5 KOO35730.1 - 1.6 8.5 6.0 1.6 8.4 0.5 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Acetyltransf_1 PF00583.19 KOO35733.1 - 8.3e-13 48.1 0.1 2.5e-12 46.6 0.0 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 KOO35733.1 - 2.2e-08 34.2 0.1 6.8e-08 32.6 0.0 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Chromo PF00385.19 KOO35733.1 - 5.4e-06 25.9 0.1 2.2e-05 24.0 0.1 2.1 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Acetyltransf_7 PF13508.1 KOO35733.1 - 0.00048 20.2 0.0 0.0011 19.0 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 KOO35733.1 - 0.0012 18.5 0.0 0.0034 17.0 0.0 1.8 1 0 0 1 1 1 1 FR47-like protein Rdx PF10262.4 KOO35734.1 - 1.1e-06 28.5 0.0 1.2e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Rdx family BCDHK_Adom3 PF10436.4 KOO35735.1 - 1.6e-20 73.2 0.0 2.7e-20 72.5 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase EF-hand_1 PF00036.27 KOO35735.1 - 3.3e-11 41.6 0.1 0.00026 20.0 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO35735.1 - 9.7e-10 37.5 0.2 0.00014 21.4 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO35735.1 - 1.1e-09 38.2 1.3 1.1e-09 38.2 0.9 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO35735.1 - 7.6e-09 34.5 0.0 0.0031 16.7 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO35735.1 - 6.8e-08 32.0 0.1 0.00014 21.3 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair HATPase_c PF02518.21 KOO35735.1 - 7.5e-06 25.6 0.0 1.2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ribosomal_L25p PF01386.14 KOO35739.1 - 0.082 13.0 0.7 0.21 11.7 0.5 1.7 1 0 0 1 1 1 0 Ribosomal L25p family DUF342 PF03961.8 KOO35739.1 - 0.74 8.1 4.8 1.1 7.5 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) TPR_12 PF13424.1 KOO35740.1 - 8.5e-30 102.5 15.9 2.9e-12 46.3 1.0 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.1 KOO35740.1 - 4e-18 64.7 43.7 1.3e-06 28.1 0.7 8.4 8 1 0 8 8 7 4 Tetratricopeptide repeat NB-ARC PF00931.17 KOO35740.1 - 5.3e-11 41.9 0.0 8.1e-11 41.3 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain NACHT PF05729.7 KOO35740.1 - 2.5e-09 37.0 0.0 6.1e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 NACHT domain TPR_11 PF13414.1 KOO35740.1 - 3.3e-07 29.8 1.3 3.3e-07 29.8 0.9 3.0 3 0 0 3 3 3 1 TPR repeat AAA_16 PF13191.1 KOO35740.1 - 7.5e-07 29.3 0.2 7.5e-07 29.3 0.2 3.0 2 0 0 2 2 1 1 AAA ATPase domain AAA_22 PF13401.1 KOO35740.1 - 8.3e-05 22.7 0.1 0.0007 19.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain TPR_8 PF13181.1 KOO35740.1 - 0.00022 20.7 1.9 0.15 11.8 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat CHAT PF12770.2 KOO35740.1 - 0.00044 19.4 0.1 0.001 18.2 0.1 1.6 1 0 0 1 1 1 1 CHAT domain TPR_7 PF13176.1 KOO35740.1 - 0.00044 19.8 12.4 0.074 12.8 0.1 4.9 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO35740.1 - 0.0013 18.8 2.8 5.1 7.5 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO35740.1 - 0.0032 17.0 11.1 0.13 11.9 0.5 4.7 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO35740.1 - 0.041 13.8 11.5 1.1 9.3 0.6 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat PPR PF01535.15 KOO35740.1 - 0.066 13.2 0.3 0.86 9.7 0.0 2.9 3 0 0 3 3 3 0 PPR repeat TPR_3 PF07720.7 KOO35740.1 - 0.081 12.7 0.4 1.7 8.5 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat KOW PF00467.24 KOO35740.1 - 0.11 12.2 0.1 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 KOW motif IstB_IS21 PF01695.12 KOO35740.1 - 0.12 11.7 0.1 0.48 9.8 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein PPR_2 PF13041.1 KOO35740.1 - 0.69 9.9 0.1 13 5.8 0.0 2.4 2 0 0 2 2 2 0 PPR repeat family Parvo_NS1 PF01057.12 KOO35740.1 - 0.73 8.6 0.0 1.2 7.9 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Arch_ATPase PF01637.13 KOO35740.1 - 0.83 9.3 0.0 1.4 8.5 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase Arm PF00514.18 KOO35741.1 - 0.011 15.5 4.5 0.2 11.5 0.2 3.1 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat BCCT PF02028.12 KOO35741.1 - 0.34 9.1 0.1 0.53 8.4 0.1 1.2 1 0 0 1 1 1 0 BCCT family transporter DUF2458 PF10454.4 KOO35742.1 - 0.74 9.6 4.9 1.3 8.9 3.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) ATP-synt_B PF00430.13 KOO35742.1 - 3.8 7.3 10.4 5.5 6.7 7.2 1.3 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Glyco_transf_41 PF13844.1 KOO35743.1 - 5.7e-67 225.6 0.0 1.2e-34 119.1 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 41 TPR_11 PF13414.1 KOO35743.1 - 4.7e-26 90.2 17.9 3.2e-08 33.1 0.0 7.0 4 2 4 8 8 8 6 TPR repeat TPR_2 PF07719.12 KOO35743.1 - 2.4e-19 67.5 17.7 0.008 16.0 0.0 9.6 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_1 PF00515.23 KOO35743.1 - 5.1e-17 60.6 5.2 0.0057 16.2 0.0 8.7 9 1 0 9 9 9 4 Tetratricopeptide repeat TPR_12 PF13424.1 KOO35743.1 - 8.2e-14 51.3 13.2 0.0029 17.4 0.3 5.4 2 2 3 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.1 KOO35743.1 - 2.3e-13 49.1 2.4 0.29 11.4 0.0 8.7 7 1 1 8 8 8 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO35743.1 - 6.1e-12 45.8 39.5 0.00048 20.7 4.7 7.5 3 2 7 10 10 9 7 Tetratricopeptide repeat TPR_14 PF13428.1 KOO35743.1 - 3.2e-09 36.5 21.5 0.0082 16.6 1.2 7.8 5 3 2 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.1 KOO35743.1 - 9.5e-09 34.4 0.0 0.13 12.0 0.0 6.1 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO35743.1 - 4.7e-05 22.8 0.3 4.3 7.3 0.0 6.1 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO35743.1 - 5.1e-05 23.5 2.6 1.4 9.3 0.1 4.7 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.1 KOO35743.1 - 0.0015 18.4 11.8 1.4 8.9 0.1 6.2 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO35743.1 - 0.012 15.4 14.7 0.62 9.9 0.2 4.9 4 1 1 5 5 5 0 Tetratricopeptide repeat DUF3856 PF12968.2 KOO35743.1 - 0.032 14.0 2.2 6.1 6.6 0.0 4.5 5 1 0 5 5 5 0 Domain of Unknown Function (DUF3856) TPR_6 PF13174.1 KOO35743.1 - 0.32 11.5 10.7 1.9 9.1 0.1 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat Glyco_transf_43 PF03360.11 KOO35747.1 - 2.8e-14 53.1 0.0 4.1e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 43 Ribosomal_L22 PF00237.14 KOO35748.1 - 5.6e-33 113.0 0.2 7.6e-33 112.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Ribosomal_S6e PF01092.14 KOO35749.1 - 1.5e-43 147.5 2.0 1.5e-43 147.5 1.4 1.5 2 0 0 2 2 2 1 Ribosomal protein S6e Ku_C PF03730.9 KOO35749.1 - 2.1 8.9 9.0 11 6.6 0.3 2.3 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm zf-UBP PF02148.14 KOO35750.1 - 1.3e-16 60.4 5.2 1.3e-16 60.4 3.6 2.0 2 0 0 2 2 1 1 Zn-finger in ubiquitin-hydrolases and other protein BRAP2 PF07576.7 KOO35750.1 - 3.9e-14 52.1 0.0 8.5e-14 51.0 0.0 1.5 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-CCCH PF00642.19 KOO35750.1 - 4.4e-10 39.0 11.2 5.8e-07 29.0 0.8 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-RING_2 PF13639.1 KOO35750.1 - 7.4e-09 35.3 10.2 7.4e-09 35.3 7.1 2.5 2 0 0 2 2 2 1 Ring finger domain RRM_6 PF14259.1 KOO35750.1 - 5e-05 23.2 0.0 0.049 13.6 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4 PF00097.20 KOO35750.1 - 0.00023 20.7 7.3 0.00023 20.7 5.1 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO35750.1 - 0.00031 20.3 18.6 0.0018 17.9 4.6 2.7 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 KOO35750.1 - 0.0011 19.0 5.2 0.0011 19.0 3.6 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 KOO35750.1 - 0.0028 17.6 9.5 0.0028 17.6 6.6 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.17 KOO35750.1 - 0.012 15.1 0.0 7.7 6.2 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-Apc11 PF12861.2 KOO35750.1 - 0.025 14.4 4.4 0.074 12.8 3.1 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 KOO35750.1 - 0.23 11.0 5.6 0.63 9.6 3.9 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF4613 PF15390.1 KOO35750.1 - 0.41 8.7 2.7 0.57 8.2 1.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) zf-RING_UBOX PF13445.1 KOO35750.1 - 0.82 9.4 12.0 0.16 11.6 1.1 3.1 2 1 0 2 2 2 0 RING-type zinc-finger HD_4 PF13328.1 KOO35751.1 - 3.8e-37 127.3 0.5 6.1e-37 126.6 0.3 1.3 1 0 0 1 1 1 1 HD domain HD PF01966.17 KOO35751.1 - 2.2e-08 34.1 0.0 6.3e-08 32.6 0.0 1.8 1 1 0 1 1 1 1 HD domain UreF PF01730.11 KOO35751.1 - 0.041 13.9 2.1 0.11 12.6 0.1 2.2 2 0 0 2 2 2 0 UreF Adipokin_hormo PF06377.6 KOO35752.1 - 0.14 12.2 2.7 0.45 10.7 0.0 2.5 2 0 0 2 2 2 0 Adipokinetic hormone VCBS PF13517.1 KOO35753.1 - 7.4e-119 388.1 136.1 3.7e-14 52.8 3.2 12.4 3 3 9 12 12 12 12 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO35753.1 - 3.9e-73 239.6 126.2 3.5e-06 26.5 2.2 13.6 13 0 0 13 13 13 13 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO35753.1 - 2.3e-24 85.7 56.6 0.15 11.4 0.1 13.1 4 3 9 13 13 13 13 Insecticide toxin TcdB middle/N-terminal region DUF4384 PF14326.1 KOO35753.1 - 2.9e-06 27.0 0.4 27 4.6 0.0 8.2 3 3 7 10 10 10 0 Domain of unknown function (DUF4384) NUDIX PF00293.23 KOO35753.1 - 0.0067 16.0 0.2 29 4.2 0.0 6.3 9 1 1 10 10 10 0 NUDIX domain EF-hand_5 PF13202.1 KOO35753.1 - 9.5 5.7 87.6 14 5.2 0.4 13.6 13 0 0 13 13 13 0 EF hand Thioredoxin_8 PF13905.1 KOO35755.1 - 2.2e-10 40.5 0.0 5.8e-10 39.1 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like HpcH_HpaI PF03328.9 KOO35756.1 - 7.7e-35 119.7 8.1 2.9e-34 117.8 1.7 2.5 2 1 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family PALP PF00291.20 KOO35756.1 - 0.089 12.0 0.2 0.089 12.0 0.1 2.7 2 1 1 3 3 3 0 Pyridoxal-phosphate dependent enzyme DUF1194 PF06707.6 KOO35756.1 - 0.23 10.4 2.4 0.2 10.5 0.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1194) Methyltransf_32 PF13679.1 KOO35758.1 - 2.2e-06 27.4 0.0 7e-06 25.7 0.0 1.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO35758.1 - 0.018 14.6 0.0 0.033 13.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 KOO35758.1 - 0.095 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain TRM13 PF05206.9 KOO35758.1 - 0.11 11.7 0.0 0.31 10.2 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase TRM13 Scramblase PF03803.10 KOO35759.1 - 1.5e-09 37.2 0.0 0.00052 19.1 0.0 2.1 2 0 0 2 2 2 2 Scramblase AAA_2 PF07724.9 KOO35760.1 - 2.7e-55 186.8 0.0 3.7e-51 173.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA PF00004.24 KOO35760.1 - 1.7e-27 96.2 0.9 3.4e-13 49.9 0.0 3.3 5 0 0 5 5 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 KOO35760.1 - 3.1e-24 84.6 0.1 1.6e-23 82.4 0.1 2.3 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.9 KOO35760.1 - 5.1e-18 65.1 1.8 1.2e-11 44.5 0.0 4.5 4 1 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOO35760.1 - 6.3e-13 49.1 5.5 0.00013 22.0 0.0 5.3 3 2 2 5 5 5 3 AAA ATPase domain Clp_N PF02861.15 KOO35760.1 - 2.6e-11 43.2 4.7 7.7e-09 35.3 0.1 3.4 3 1 0 3 3 2 2 Clp amino terminal domain AAA_22 PF13401.1 KOO35760.1 - 6.1e-11 42.5 3.5 0.0011 19.1 0.0 5.1 2 2 1 3 3 3 2 AAA domain Sigma54_activat PF00158.21 KOO35760.1 - 2e-09 37.1 0.0 1.9e-05 24.2 0.0 2.9 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_17 PF13207.1 KOO35760.1 - 2.2e-09 38.1 3.3 0.00058 20.6 0.0 4.2 4 1 0 4 4 3 2 AAA domain IstB_IS21 PF01695.12 KOO35760.1 - 3.4e-09 36.3 0.0 0.0018 17.7 0.0 2.7 3 0 0 3 3 2 2 IstB-like ATP binding protein AAA_18 PF13238.1 KOO35760.1 - 6.3e-08 32.9 0.7 0.011 16.0 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_14 PF13173.1 KOO35760.1 - 1.4e-06 28.1 0.0 0.025 14.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 KOO35760.1 - 2.7e-06 27.1 0.0 0.017 14.7 0.0 2.9 3 0 0 3 3 2 2 NACHT domain Mg_chelatase PF01078.16 KOO35760.1 - 6.6e-06 25.4 0.2 0.4 9.8 0.0 3.9 2 1 1 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 KOO35760.1 - 1.9e-05 24.3 1.0 0.18 11.5 0.0 4.2 4 0 0 4 4 3 2 Part of AAA domain Zeta_toxin PF06414.7 KOO35760.1 - 1.9e-05 23.8 0.1 0.036 13.1 0.0 3.4 3 1 0 3 3 3 1 Zeta toxin RuvB_N PF05496.7 KOO35760.1 - 2.1e-05 23.6 0.5 0.63 9.0 0.0 3.9 5 0 0 5 5 3 2 Holliday junction DNA helicase ruvB N-terminus RNA_helicase PF00910.17 KOO35760.1 - 3.8e-05 23.8 0.0 0.24 11.5 0.0 2.9 3 0 0 3 3 2 2 RNA helicase AAA_28 PF13521.1 KOO35760.1 - 8.5e-05 22.5 1.3 1.1 9.2 0.0 3.9 3 1 0 3 3 3 2 AAA domain AAA_3 PF07726.6 KOO35760.1 - 0.00011 21.8 0.1 0.15 11.6 0.0 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.18 KOO35760.1 - 0.00015 21.7 0.0 0.23 11.4 0.0 2.9 2 1 1 3 3 2 1 50S ribosome-binding GTPase AAA_25 PF13481.1 KOO35760.1 - 0.00016 21.1 0.8 0.18 11.2 0.0 3.2 2 2 0 2 2 2 1 AAA domain AAA_23 PF13476.1 KOO35760.1 - 0.00018 21.9 1.5 3.4 7.9 0.0 3.3 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.1 KOO35760.1 - 0.00026 20.8 0.2 0.16 11.8 0.0 3.1 3 0 0 3 3 2 1 AAA domain Arch_ATPase PF01637.13 KOO35760.1 - 0.0012 18.6 0.0 1.5 8.4 0.0 3.8 2 2 1 3 3 3 1 Archaeal ATPase AAA_24 PF13479.1 KOO35760.1 - 0.0032 17.0 0.0 0.41 10.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 KOO35760.1 - 0.0033 16.9 1.7 0.52 9.6 0.0 3.8 3 1 0 3 3 3 1 AAA-like domain DUF258 PF03193.11 KOO35760.1 - 0.0035 16.5 0.0 0.77 8.9 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 T2SE PF00437.15 KOO35760.1 - 0.004 16.1 0.0 0.022 13.6 0.0 2.1 2 0 0 2 2 2 1 Type II/IV secretion system protein TIP49 PF06068.8 KOO35760.1 - 0.0057 15.4 0.4 0.5 9.0 0.0 2.9 3 0 0 3 3 3 1 TIP49 C-terminus DNA_pol3_delta2 PF13177.1 KOO35760.1 - 0.0063 16.1 0.0 0.17 11.5 0.0 2.9 2 1 0 2 2 2 1 DNA polymerase III, delta subunit RapA_C PF12137.3 KOO35760.1 - 0.0093 14.8 4.6 0.028 13.2 3.2 1.7 2 0 0 2 2 2 1 RNA polymerase recycling family C-terminal ABC_tran PF00005.22 KOO35760.1 - 0.011 16.0 0.5 1.3 9.3 0.0 3.0 3 0 0 3 3 2 0 ABC transporter MobB PF03205.9 KOO35760.1 - 0.015 15.0 0.0 0.5 10.0 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Bac_DnaA PF00308.13 KOO35760.1 - 0.02 14.5 0.0 0.76 9.3 0.0 2.8 3 0 0 3 3 3 0 Bacterial dnaA protein NTPase_1 PF03266.10 KOO35760.1 - 0.023 14.4 0.1 8.6 6.0 0.0 3.0 3 0 0 3 3 3 0 NTPase ResIII PF04851.10 KOO35760.1 - 0.042 13.6 0.1 1.6 8.4 0.0 2.9 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit V_ATPase_I PF01496.14 KOO35760.1 - 0.053 11.3 2.6 0.076 10.8 1.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family UPF0079 PF02367.12 KOO35760.1 - 0.065 12.8 0.0 6.4 6.4 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 PduV-EutP PF10662.4 KOO35760.1 - 0.13 11.7 0.0 3.2 7.2 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Parvo_NS1 PF01057.12 KOO35760.1 - 0.16 10.8 0.1 30 3.3 0.0 2.9 2 1 1 3 3 3 0 Parvovirus non-structural protein NS1 Spc7 PF08317.6 KOO35760.1 - 0.16 10.6 6.5 0.26 9.9 4.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Snapin_Pallidin PF14712.1 KOO35760.1 - 0.47 10.7 5.2 1.1 9.6 1.1 2.8 2 0 0 2 2 2 0 Snapin/Pallidin FemAB PF02388.11 KOO35760.1 - 1.3 7.6 2.7 1.9 7.0 1.9 1.2 1 0 0 1 1 1 0 FemAB family RINGv PF12906.2 KOO35763.1 - 4e-12 45.9 2.7 8.1e-12 44.9 1.9 1.5 1 0 0 1 1 1 1 RING-variant domain FANCL_C PF11793.3 KOO35763.1 - 0.028 14.3 2.3 0.057 13.3 1.6 1.6 1 0 0 1 1 1 0 FANCL C-terminal domain PHD PF00628.24 KOO35763.1 - 0.037 13.7 3.4 0.067 12.8 2.4 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING_2 PF13639.1 KOO35763.1 - 0.91 9.4 3.8 1.7 8.5 2.6 1.4 1 0 0 1 1 1 0 Ring finger domain Aminotran_1_2 PF00155.16 KOO35765.1 - 0.0028 16.6 0.2 0.0033 16.4 0.2 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Mito_carr PF00153.22 KOO35766.1 - 1.6e-18 66.2 9.1 9.4e-06 25.2 0.1 4.6 3 1 0 3 3 3 3 Mitochondrial carrier protein DEC-1_N PF04625.8 KOO35766.1 - 6.1 5.4 11.9 10 4.6 8.3 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region VWA PF00092.23 KOO35767.1 - 2.1e-22 79.7 0.0 2.6e-22 79.3 0.0 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.1 KOO35767.1 - 1.1e-16 61.4 3.4 1.3e-16 61.1 2.4 1.0 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.9 KOO35767.1 - 2e-06 27.1 0.1 2.4e-06 26.8 0.1 1.1 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein DUF1194 PF06707.6 KOO35767.1 - 0.0022 17.0 0.4 0.0029 16.6 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1194) CS PF04969.11 KOO35771.1 - 9e-10 38.9 0.0 1.4e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 CS domain Aldose_epim PF01263.15 KOO35772.1 - 8.4e-33 113.7 0.0 1.2e-32 113.1 0.0 1.2 1 0 0 1 1 1 1 Aldose 1-epimerase DUF3729 PF12526.3 KOO35772.1 - 3.6 8.9 8.2 9 7.6 5.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3729) EF-hand_7 PF13499.1 KOO35776.1 - 5.8e-20 71.2 0.3 2.4e-10 40.4 0.4 4.3 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO35776.1 - 2.1e-17 61.3 0.2 0.0041 16.8 0.0 6.5 5 0 0 5 5 5 3 EF-hand domain EF-hand_1 PF00036.27 KOO35776.1 - 7.4e-16 56.1 0.0 0.00013 20.9 0.0 5.1 6 0 0 6 6 6 3 EF hand EF-hand_8 PF13833.1 KOO35776.1 - 7.9e-13 47.8 4.2 3.7e-07 29.6 0.1 4.8 5 0 0 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO35776.1 - 6.8e-09 34.6 6.5 0.0022 17.2 0.0 4.4 4 0 0 4 4 4 3 EF hand SPARC_Ca_bdg PF10591.4 KOO35776.1 - 0.029 14.3 0.4 9.1 6.3 0.0 3.2 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region BTB PF00651.26 KOO35777.1 - 7.3e-23 80.6 0.1 4.6e-22 78.1 0.0 2.1 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.10 KOO35777.1 - 7.8e-23 80.2 0.0 1.4e-22 79.4 0.0 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch SbmA_BacA PF05992.7 KOO35778.1 - 1.3e-36 126.4 0.3 7.7e-36 123.8 0.2 1.8 1 1 0 1 1 1 1 SbmA/BacA-like family ABC_membrane_2 PF06472.10 KOO35778.1 - 1.2e-07 31.2 0.1 3.2e-07 29.7 0.0 1.6 1 1 0 1 1 1 1 ABC transporter transmembrane region 2 DnaJ PF00226.26 KOO35779.1 - 0.00028 20.5 0.1 0.00091 18.9 0.1 2.0 1 0 0 1 1 1 1 DnaJ domain DUF3074 PF11274.3 KOO35779.1 - 0.085 12.4 0.2 0.23 11.0 0.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3074) GAGA_bind PF06217.7 KOO35779.1 - 0.14 12.1 1.6 0.16 11.9 1.1 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family SlyX PF04102.7 KOO35779.1 - 7.8 6.9 9.4 28 5.1 0.5 3.5 2 1 1 3 3 3 0 SlyX Ion_trans PF00520.26 KOO35782.1 - 2.5e-10 39.9 2.4 3.9e-10 39.3 1.7 1.4 1 0 0 1 1 1 1 Ion transport protein Ank_2 PF12796.2 KOO35782.1 - 7.7e-05 22.9 0.1 0.00027 21.2 0.1 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO35782.1 - 0.00015 22.2 0.1 0.44 11.1 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) WD40 PF00400.27 KOO35782.1 - 0.00076 19.2 0.0 3.1 7.8 0.0 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat Ank_3 PF13606.1 KOO35782.1 - 0.011 15.8 0.2 0.93 9.9 0.0 3.4 2 0 0 2 2 2 0 Ankyrin repeat Ank_5 PF13857.1 KOO35782.1 - 0.015 15.5 0.2 2.6 8.4 0.0 2.7 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Ank PF00023.25 KOO35782.1 - 0.099 12.5 0.0 1.5 8.7 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeat PKD_channel PF08016.7 KOO35782.1 - 0.15 10.4 15.6 0.0087 14.5 6.6 2.0 2 1 0 2 2 2 0 Polycystin cation channel PseudoU_synth_2 PF00849.17 KOO35783.1 - 2e-26 92.7 0.0 3.7e-26 91.9 0.0 1.5 1 0 0 1 1 1 1 RNA pseudouridylate synthase Glyco_trans_2_3 PF13632.1 KOO35783.1 - 0.064 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family group 2 MOSC_N PF03476.11 KOO35784.1 - 1.6e-31 108.4 0.0 3.2e-31 107.5 0.0 1.5 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain MOSC PF03473.12 KOO35784.1 - 3.4e-19 68.6 0.0 6.5e-19 67.7 0.0 1.4 1 0 0 1 1 1 1 MOSC domain GHMP_kinases_N PF00288.21 KOO35785.1 - 0.036 14.1 2.6 0.091 12.8 1.3 2.0 2 0 0 2 2 2 0 GHMP kinases N terminal domain FKBP_C PF00254.23 KOO35786.1 - 1.9e-19 69.4 0.0 3.2e-19 68.7 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF4511 PF14974.1 KOO35786.1 - 3.5e-11 42.7 0.8 5.6e-11 42.1 0.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4511) FKBP_N PF01346.13 KOO35786.1 - 4.3e-09 36.4 0.0 1.4e-08 34.7 0.0 1.9 2 0 0 2 2 2 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Methyltransf_33 PF10017.4 KOO35787.1 - 2.8e-26 91.8 0.4 7.2e-26 90.5 0.3 1.7 1 1 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent FGE-sulfatase PF03781.11 KOO35787.1 - 3.1e-20 72.6 0.0 1.9e-19 70.0 0.0 2.0 1 1 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 Glycos_transf_1 PF00534.15 KOO35787.1 - 1.1e-15 57.5 0.0 5.3e-15 55.2 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 KOO35787.1 - 1e-11 45.1 0.4 3.9e-11 43.2 0.3 2.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 KOO35787.1 - 4.6e-05 23.6 0.0 0.00015 21.9 0.0 1.9 1 0 0 1 1 1 1 Glycosyl transferases group 1 Methyltransf_25 PF13649.1 KOO35787.1 - 0.0034 17.7 0.0 0.011 16.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain CSD PF00313.17 KOO35788.1 - 1.4e-13 50.3 0.1 2.6e-13 49.5 0.1 1.5 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain PseudoU_synth_2 PF00849.17 KOO35788.1 - 8.9e-05 22.3 0.0 0.00013 21.8 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase OB_RNB PF08206.6 KOO35788.1 - 0.11 12.0 0.1 0.28 10.7 0.0 1.7 2 0 0 2 2 2 0 Ribonuclease B OB domain Condensation PF00668.15 KOO35789.1 - 0.00084 18.2 0.0 1.1 8.0 0.0 3.0 3 0 0 3 3 3 2 Condensation domain AATase PF07247.7 KOO35789.1 - 0.062 11.8 0.0 0.23 9.9 0.0 1.7 2 0 0 2 2 2 0 Alcohol acetyltransferase Ion_trans PF00520.26 KOO35793.1 - 1.1 8.4 13.4 0.68 9.1 0.7 3.5 4 1 0 4 4 4 0 Ion transport protein Myotub-related PF06602.9 KOO35794.1 - 1.4e-61 208.2 0.0 1.8e-61 207.9 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Ribosomal_S25 PF03297.10 KOO35795.1 - 2.5e-41 139.9 4.3 2.8e-41 139.8 3.0 1.0 1 0 0 1 1 1 1 S25 ribosomal protein HTH_24 PF13412.1 KOO35795.1 - 0.015 14.6 0.2 0.028 13.8 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding TrmB PF01978.14 KOO35795.1 - 0.026 14.2 0.1 0.047 13.3 0.0 1.5 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_27 PF13463.1 KOO35795.1 - 0.067 13.5 0.0 0.098 12.9 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain Fe_dep_repress PF01325.14 KOO35795.1 - 0.12 12.3 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain CorA PF01544.13 KOO35798.1 - 1.2e-19 70.4 0.0 1.7e-19 69.9 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Arylsulfotrans PF05935.6 KOO35798.1 - 0.02 13.4 0.0 0.039 12.4 0.0 1.4 2 0 0 2 2 2 0 Arylsulfotransferase (ASST) adh_short PF00106.20 KOO35799.1 - 8.2e-07 29.0 0.1 1.5e-05 24.9 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase Pyr_redox_2 PF07992.9 KOO35800.1 - 2.2e-15 57.0 0.0 1.7e-05 24.8 0.0 3.2 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOO35800.1 - 4.4e-11 43.0 0.5 7.2e-05 23.1 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOO35800.1 - 0.0022 18.0 0.0 0.0056 16.7 0.0 1.7 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 KOO35800.1 - 0.0072 16.1 1.6 0.13 11.9 0.0 2.6 2 0 0 2 2 2 1 FAD-NAD(P)-binding K_oxygenase PF13434.1 KOO35800.1 - 0.074 11.9 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) UDPG_MGDP_dh_N PF03721.9 KOO35800.1 - 0.12 11.7 0.5 0.21 10.9 0.4 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UBA PF00627.26 KOO35801.1 - 3.1e-07 30.0 0.2 1.1e-06 28.3 0.1 2.0 1 0 0 1 1 1 1 UBA/TS-N domain F-box PF00646.28 KOO35801.1 - 0.0028 17.2 2.1 0.0072 15.9 1.5 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 KOO35801.1 - 0.045 13.4 0.1 0.099 12.3 0.0 1.6 1 0 0 1 1 1 0 F-box-like Methyltransf_16 PF10294.4 KOO35802.1 - 4.3e-08 32.8 0.0 6.4e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_26 PF13659.1 KOO35802.1 - 4.4e-06 26.7 0.7 2.9e-05 24.0 0.1 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO35802.1 - 0.00032 21.2 0.1 0.00053 20.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOO35802.1 - 0.0032 16.8 0.1 0.0054 16.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain ZZ PF00569.12 KOO35802.1 - 0.018 14.5 0.1 0.047 13.2 0.0 1.7 2 0 0 2 2 2 0 Zinc finger, ZZ type Methyltransf_11 PF08241.7 KOO35802.1 - 0.02 15.3 0.0 0.043 14.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.1 KOO35802.1 - 0.078 12.5 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Pkinase PF00069.20 KOO35803.1 - 3.6e-67 226.2 0.0 4e-66 222.8 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO35803.1 - 6.1e-36 123.8 0.1 8.2e-35 120.1 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO35803.1 - 0.0003 19.8 0.0 0.0004 19.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOO35803.1 - 0.00078 18.5 0.0 0.0013 17.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family BTB PF00651.26 KOO35804.1 - 7.1e-18 64.6 0.0 1.9e-17 63.2 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.10 KOO35804.1 - 1.7e-12 47.0 0.2 4.2e-12 45.8 0.1 1.7 1 0 0 1 1 1 1 BTB And C-terminal Kelch MATH PF00917.21 KOO35804.1 - 0.042 14.1 0.1 0.11 12.7 0.0 1.7 2 0 0 2 2 2 0 MATH domain DUF2930 PF11152.3 KOO35805.1 - 2.4e-09 36.6 0.0 3e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2930) PAS_9 PF13426.1 KOO35806.1 - 9.3e-29 99.8 0.0 3.1e-13 49.9 0.0 2.9 3 0 0 3 3 3 2 PAS domain PAS PF00989.19 KOO35806.1 - 6.1e-09 35.6 0.0 0.00038 20.2 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.5 KOO35806.1 - 0.00012 22.0 0.0 0.028 14.4 0.0 2.9 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.1 KOO35806.1 - 0.0019 18.0 0.0 2.2 8.2 0.0 2.9 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.6 KOO35806.1 - 0.0023 17.9 0.0 1.4 9.0 0.0 2.6 2 0 0 2 2 2 2 PAS fold Kinesin PF00225.18 KOO35807.1 - 1.5e-37 129.0 0.0 4e-34 117.8 0.2 2.1 2 0 0 2 2 2 2 Kinesin motor domain WW PF00397.21 KOO35807.1 - 4.5e-05 23.2 0.8 8.8e-05 22.2 0.6 1.4 1 0 0 1 1 1 1 WW domain RNase_PH PF01138.16 KOO35808.1 - 7.3e-26 91.0 0.1 1.2e-25 90.3 0.1 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 KOO35808.1 - 0.025 14.5 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 Syntaxin PF00804.20 KOO35810.1 - 2.3e-16 59.7 6.2 2.3e-16 59.7 4.3 2.1 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.14 KOO35810.1 - 2.8e-15 55.7 0.4 2.8e-15 55.7 0.3 2.5 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.1 KOO35810.1 - 0.00014 21.8 5.3 0.00014 21.8 3.7 2.2 2 1 0 2 2 2 1 Syntaxin-like protein GCIP PF13324.1 KOO35810.1 - 0.0028 16.9 1.5 0.0043 16.3 0.5 1.6 2 0 0 2 2 2 1 Grap2 and cyclin-D-interacting DUF342 PF03961.8 KOO35810.1 - 0.0059 15.0 1.3 0.0059 15.0 0.9 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF342) VitD-bind_III PF09164.5 KOO35810.1 - 0.039 13.5 0.1 0.12 12.0 0.0 1.9 1 0 0 1 1 1 0 Vitamin D binding protein, domain III Peptidase_U57 PF05582.7 KOO35810.1 - 0.77 8.6 7.6 1.4 7.7 5.1 1.5 1 1 0 1 1 1 0 YabG peptidase U57 Baculo_PEP_C PF04513.7 KOO35810.1 - 1.3 8.8 7.3 1.8 8.3 0.9 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus PsaN PF05479.6 KOO35810.1 - 1.9 8.4 4.3 2.4 8.1 0.0 2.6 2 1 0 3 3 3 0 Photosystem I reaction centre subunit N (PSAN or PSI-N) HisKA PF00512.20 KOO35810.1 - 3.5 7.6 7.2 2.3 8.3 0.6 3.1 3 0 0 3 3 3 0 His Kinase A (phospho-acceptor) domain Peptidase_M14 PF00246.19 KOO35811.1 - 1.3e-14 54.5 0.0 2e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase BACK PF07707.10 KOO35813.1 - 5.2e-18 64.7 0.0 7.5e-18 64.2 0.0 1.3 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.26 KOO35813.1 - 3.5e-08 33.4 0.0 6.2e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain DUF2293 PF10056.4 KOO35813.1 - 0.047 13.6 0.5 2.1 8.3 0.0 2.8 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2293) Skp1 PF01466.14 KOO35813.1 - 0.13 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Skp1 family, dimerisation domain DUF1325 PF07039.6 KOO35814.1 - 0.094 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 SGF29 tudor-like domain Fer4_15 PF13459.1 KOO35815.1 - 4e-15 56.1 5.2 1.5e-14 54.3 3.6 2.1 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_13 PF13370.1 KOO35815.1 - 8.6e-11 42.0 6.1 3.1e-10 40.2 4.2 2.0 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_9 PF13187.1 KOO35815.1 - 0.038 14.2 6.1 0.038 14.2 4.3 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_7 PF12838.2 KOO35815.1 - 1.9 8.9 12.5 0.25 11.7 0.5 2.9 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_19 PF06902.6 KOO35815.1 - 2.3 8.1 7.8 0.15 11.9 0.7 2.3 3 0 0 3 3 3 0 Divergent 4Fe-4S mono-cluster EF-hand_6 PF13405.1 KOO35817.1 - 8.5e-17 59.4 4.4 5.6e-06 25.8 0.1 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.27 KOO35817.1 - 9.2e-16 55.8 2.6 1.7e-05 23.7 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO35817.1 - 9e-14 50.8 0.7 1.1e-08 34.5 0.4 3.7 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.1 KOO35817.1 - 1.7e-13 50.5 4.8 9.1e-09 35.3 0.8 3.6 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO35817.1 - 2.1e-10 39.4 12.4 0.00028 20.0 0.8 4.3 4 0 0 4 4 4 3 EF hand WxL PF13731.1 KOO35817.1 - 0.024 14.4 1.9 0.068 12.9 1.3 1.7 1 0 0 1 1 1 0 WxL domain surface cell wall-binding Tecti-min-caps PF09300.5 KOO35818.1 - 0.039 13.7 0.1 0.099 12.4 0.1 1.7 1 0 0 1 1 1 0 Tectiviridae, minor capsid LRR_5 PF13306.1 KOO35821.1 - 6.4e-127 417.1 0.7 3.2e-47 159.4 0.0 3.4 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO35821.1 - 1.1e-27 95.5 0.0 0.0002 21.0 0.0 7.3 2 2 7 9 9 9 9 Leucine rich repeat KH_1 PF00013.24 KOO35824.1 - 2e-08 33.7 0.0 3.4e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 KOO35824.1 - 1.4e-06 27.8 0.0 2.5e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 KH domain KH_2 PF07650.12 KOO35824.1 - 2.5e-05 23.7 0.0 4.5e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 KH domain KH_4 PF13083.1 KOO35824.1 - 0.021 14.4 0.0 0.04 13.5 0.0 1.4 1 0 0 1 1 1 0 KH domain Levi_coat PF01819.12 KOO35824.1 - 0.12 11.9 0.0 0.28 10.7 0.0 1.6 1 0 0 1 1 1 0 Levivirus coat protein Helicase_C PF00271.26 KOO35825.1 - 2.8e-10 39.9 0.6 6.6e-10 38.7 0.4 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOO35825.1 - 4.4e-08 32.7 0.1 2.2e-07 30.5 0.1 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 KOO35825.1 - 0.00022 21.3 0.1 0.003 17.7 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.1 KOO35825.1 - 0.00023 20.8 0.1 0.0012 18.5 0.1 2.2 1 0 0 1 1 1 1 Part of AAA domain Herpes_ori_bp PF02399.10 KOO35825.1 - 0.00051 18.1 0.0 0.0022 16.0 0.0 1.9 3 0 0 3 3 3 1 Origin of replication binding protein T2SE PF00437.15 KOO35825.1 - 0.0044 15.9 0.0 0.013 14.4 0.0 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein NUDIX PF00293.23 KOO35825.1 - 0.0072 15.9 0.0 0.021 14.4 0.0 1.8 1 0 0 1 1 1 1 NUDIX domain PhoH PF02562.11 KOO35825.1 - 0.041 13.1 0.0 2.7 7.1 0.0 3.5 4 0 0 4 4 4 0 PhoH-like protein Herpes_UL37_1 PF03970.8 KOO35825.1 - 0.075 11.8 0.0 0.13 11.0 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus UL37 tegument protein HCNGP PF07818.8 KOO35827.1 - 3.7e-25 87.7 0.0 5.7e-25 87.1 0.0 1.3 1 0 0 1 1 1 1 HCNGP-like protein PAT1 PF09770.4 KOO35828.1 - 3.9 5.5 7.7 4.2 5.4 5.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF830 PF05708.7 KOO35829.1 - 8.9e-07 29.0 0.0 0.0028 17.6 0.0 2.2 2 0 0 2 2 2 2 Orthopoxvirus protein of unknown function (DUF830) TetR_C_6 PF13977.1 KOO35829.1 - 0.044 13.8 1.2 0.044 13.8 0.8 2.4 3 0 0 3 3 3 0 Bacterial transcriptional repressor TIG PF01833.19 KOO35830.1 - 1.6e-53 178.6 0.0 1.1e-10 41.3 0.0 12.1 11 1 0 11 11 11 11 IPT/TIG domain LRRCT PF01463.19 KOO35830.1 - 0.46 10.9 7.3 5.1 7.6 0.0 5.3 5 0 0 5 5 5 0 Leucine rich repeat C-terminal domain Sel1 PF08238.7 KOO35831.1 - 0.00014 22.3 0.3 0.0017 18.9 0.1 2.3 2 0 0 2 2 2 1 Sel1 repeat DUF972 PF06156.8 KOO35832.1 - 0.018 15.3 1.1 0.018 15.3 0.8 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF972) APG6 PF04111.7 KOO35832.1 - 0.29 10.1 25.8 0.4 9.6 8.2 2.4 1 1 1 2 2 2 0 Autophagy protein Apg6 Baculo_PEP_C PF04513.7 KOO35832.1 - 1 9.2 8.7 0.3 10.9 0.5 3.3 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2312 PF10073.4 KOO35832.1 - 1.5 8.2 8.1 14 5.1 0.1 4.1 5 0 0 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2312) Atg14 PF10186.4 KOO35832.1 - 8.5 5.2 21.1 0.06 12.2 4.1 2.3 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 LRR_6 PF13516.1 KOO35834.1 - 1.1e-12 46.6 16.0 0.025 14.6 0.2 6.1 7 0 0 7 7 7 5 Leucine Rich repeat LRR_4 PF12799.2 KOO35834.1 - 1.4e-08 34.1 3.4 0.0048 16.5 0.1 3.6 1 1 3 4 4 4 3 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO35834.1 - 4.9e-05 22.8 6.8 9.9 6.8 0.0 5.9 6 0 0 6 6 6 2 Leucine rich repeat LRR_1 PF00560.28 KOO35834.1 - 0.00019 21.0 0.0 47 4.5 0.0 5.3 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_8 PF13855.1 KOO35834.1 - 0.006 16.3 6.2 0.16 11.7 1.9 3.3 1 1 2 3 3 3 3 Leucine rich repeat Phage_integ_N PF09003.5 KOO35834.1 - 1.3 8.7 5.2 36 4.1 0.2 3.5 2 1 1 3 3 3 0 Bacteriophage lambda integrase, N-terminal domain Dpy-30 PF05186.8 KOO35835.1 - 0.012 15.0 0.1 0.027 13.9 0.1 1.5 1 0 0 1 1 1 0 Dpy-30 motif Arm PF00514.18 KOO35836.1 - 0.0018 18.0 5.3 1.9 8.4 0.2 3.3 3 0 0 3 3 3 3 Armadillo/beta-catenin-like repeat Exo_endo_phos PF03372.18 KOO35838.1 - 0.0054 16.6 0.5 0.0094 15.9 0.3 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ribosomal_60s PF00428.14 KOO35840.1 - 0.079 13.3 3.4 0.14 12.5 2.4 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein ATP_synt_I PF03899.10 KOO35842.1 - 0.0042 17.2 7.4 0.025 14.7 5.1 2.0 1 1 0 1 1 1 1 ATP synthase I chain ABC1 PF03109.11 KOO35843.1 - 2.3e-33 114.7 0.0 4e-33 113.8 0.0 1.4 1 0 0 1 1 1 1 ABC1 family Choline_kinase PF01633.15 KOO35843.1 - 0.19 11.2 0.0 3.6 7.1 0.0 2.1 2 0 0 2 2 2 0 Choline/ethanolamine kinase MFS_1 PF07690.11 KOO35844.1 - 2.3e-20 72.6 45.7 3e-16 59.1 11.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.20 KOO35845.1 - 2.7e-55 187.3 0.0 3.3e-55 187.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO35845.1 - 3.7e-31 108.1 0.0 4.6e-31 107.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO35845.1 - 1.1e-05 24.6 0.0 1.4e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like DSBA PF01323.15 KOO35846.1 - 2.7e-10 40.1 0.3 3.1e-10 39.9 0.2 1.1 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_5 PF13743.1 KOO35846.1 - 0.0032 17.0 0.0 0.004 16.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DUF1525 PF07511.6 KOO35846.1 - 0.12 12.3 0.1 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) FHA PF00498.21 KOO35847.1 - 5e-15 55.3 0.1 7.2e-15 54.8 0.1 1.2 1 0 0 1 1 1 1 FHA domain DUF2649 PF10854.3 KOO35848.1 - 0.00046 20.2 1.2 0.031 14.4 0.1 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF2649) TIR_2 PF13676.1 KOO35849.1 - 1.6e-10 40.9 0.2 1.4e-09 37.9 0.0 2.2 2 0 0 2 2 2 1 TIR domain TIR PF01582.15 KOO35849.1 - 0.15 11.4 0.0 0.3 10.5 0.0 1.4 1 0 0 1 1 1 0 TIR domain Gp-FAR-1 PF05823.7 KOO35850.1 - 0.0017 18.3 3.7 0.44 10.5 0.1 2.6 1 1 1 2 2 2 2 Nematode fatty acid retinoid binding protein (Gp-FAR-1) HHH_2 PF12826.2 KOO35850.1 - 0.06 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif Apolipoprotein PF01442.13 KOO35850.1 - 0.5 9.8 8.0 0.55 9.7 2.2 2.2 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF883 PF05957.8 KOO35850.1 - 6 7.3 20.1 0.11 12.9 3.4 3.7 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF883) DUF3585 PF12130.3 KOO35850.1 - 7.9 6.3 10.1 15 5.4 0.9 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3585) DUF1207 PF06727.6 KOO35851.1 - 0.17 10.6 0.0 0.25 10.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1207) DUF4013 PF13197.1 KOO35853.1 - 0.42 9.9 2.9 0.55 9.5 2.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4013) Paramecium_SA PF01508.11 KOO35854.1 - 1.1 9.4 8.1 2.1 8.6 5.6 1.4 1 0 0 1 1 1 0 Paramecium surface antigen domain SSP160 PF06933.6 KOO35855.1 - 2.9 5.7 7.5 4.4 5.1 5.2 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Coq4 PF05019.8 KOO35858.1 - 3e-62 209.4 0.0 3.5e-62 209.2 0.0 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Glyco_trans_1_4 PF13692.1 KOO35858.1 - 0.088 12.9 0.1 0.14 12.3 0.1 1.5 1 1 0 1 1 1 0 Glycosyl transferases group 1 Guanylate_cyc_2 PF09778.4 KOO35858.1 - 0.096 11.8 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Guanylylate cyclase Pkinase PF00069.20 KOO35859.1 - 1.3e-35 122.8 0.0 2e-35 122.1 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO35859.1 - 7.6e-14 51.3 0.0 3.5e-12 45.9 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO35859.1 - 0.0034 17.1 0.0 0.01 15.5 0.0 1.8 2 1 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 KOO35859.1 - 0.04 12.7 0.3 0.062 12.0 0.2 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF819 PF05684.7 KOO35860.1 - 1.7e-09 36.9 0.1 1.7e-09 36.9 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF819) Hist_deacetyl PF00850.14 KOO35863.1 - 3.3e-49 167.8 0.0 4.3e-49 167.4 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Myb_DNA-binding PF00249.26 KOO35864.1 - 6.6e-21 74.1 0.6 8.1e-11 41.8 0.0 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO35864.1 - 1.6e-16 60.0 0.1 1.2e-07 31.6 0.1 2.1 2 0 0 2 2 2 2 Myb-like DNA-binding domain DUF4096 PF13340.1 KOO35864.1 - 0.033 14.0 0.4 8.1 6.3 0.0 2.3 2 0 0 2 2 2 0 Putative transposase of IS4/5 family (DUF4096) Myb_DNA-bind_5 PF13873.1 KOO35864.1 - 0.11 12.4 0.4 12 5.8 0.0 2.5 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain Ribosomal_60s PF00428.14 KOO35864.1 - 0.74 10.2 7.4 0.36 11.2 3.4 1.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein NAGLU PF05089.7 KOO35865.1 - 1.9e-119 398.3 5.1 2.7e-119 397.8 3.6 1.2 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.2 KOO35865.1 - 2.1e-52 178.1 3.2 3.1e-48 164.4 3.6 2.1 2 0 0 2 2 2 2 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU_N PF12971.2 KOO35865.1 - 1.9e-08 33.8 0.0 5.5e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain Dimer_Tnp_hAT PF05699.9 KOO35867.1 - 1.2e-06 27.9 0.2 1.7e-06 27.5 0.1 1.3 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region PX PF00787.19 KOO35868.1 - 5.6e-08 32.5 0.0 1.2e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 PX domain Glyoxalase_2 PF12681.2 KOO35872.1 - 8.9e-14 52.0 0.0 1e-13 51.8 0.0 1.0 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.20 KOO35872.1 - 1.4e-07 31.4 0.0 1.9e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.1 KOO35872.1 - 0.033 14.2 0.0 0.1 12.6 0.0 1.7 2 0 0 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Hydrolase_3 PF08282.7 KOO35873.1 - 8.9e-38 130.3 0.0 9.9e-38 130.1 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.8 KOO35873.1 - 6.5e-09 35.4 0.0 8.4e-09 35.0 0.0 1.1 1 0 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase CHAT PF12770.2 KOO35875.1 - 5.5e-07 29.0 0.1 1.2e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 CHAT domain NACHT PF05729.7 KOO35875.1 - 2.8e-05 23.8 0.0 9e-05 22.1 0.0 1.9 1 1 0 1 1 1 1 NACHT domain AAA_19 PF13245.1 KOO35875.1 - 3.3e-05 23.5 6.5 0.00049 19.7 4.5 2.9 1 1 0 1 1 1 1 Part of AAA domain NB-ARC PF00931.17 KOO35875.1 - 8.4e-05 21.5 0.0 0.00013 20.9 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.1 KOO35875.1 - 0.00031 20.7 1.9 0.00035 20.6 0.2 2.0 2 0 0 2 2 1 1 AAA ATPase domain AAA_22 PF13401.1 KOO35875.1 - 0.00057 20.0 0.0 0.0015 18.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain LRR_4 PF12799.2 KOO35875.1 - 0.012 15.2 1.2 0.086 12.4 0.0 2.6 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) PhoH PF02562.11 KOO35875.1 - 0.038 13.2 0.0 0.066 12.4 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.1 KOO35875.1 - 0.039 13.3 0.1 0.089 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain MobB PF03205.9 KOO35875.1 - 0.045 13.4 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Arch_ATPase PF01637.13 KOO35875.1 - 0.082 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase LRR_6 PF13516.1 KOO35875.1 - 0.085 12.9 0.2 26 5.3 0.0 3.1 2 1 0 2 2 2 0 Leucine Rich repeat NTPase_1 PF03266.10 KOO35875.1 - 0.31 10.7 0.0 0.62 9.7 0.0 1.5 1 0 0 1 1 1 0 NTPase LRR_1 PF00560.28 KOO35875.1 - 0.36 11.0 1.9 4.3 7.7 0.1 3.0 2 0 0 2 2 2 0 Leucine Rich Repeat Mito_carr PF00153.22 KOO35878.1 - 2.7e-35 119.9 3.3 4e-18 64.9 0.4 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein SpoVAB PF13782.1 KOO35878.1 - 0.38 10.7 2.6 1.7 8.6 0.1 2.8 3 0 0 3 3 3 0 Stage V sporulation protein AB TAFH PF07531.9 KOO35879.1 - 0.056 13.0 0.6 0.4 10.3 0.3 2.6 2 0 0 2 2 2 0 NHR1 homology to TAF Nsp1_C PF05064.8 KOO35879.1 - 0.21 11.2 7.9 0.16 11.6 1.3 2.8 2 0 0 2 2 2 0 Nsp1-like C-terminal region Phage_base_V PF04717.7 KOO35880.1 - 0.048 13.5 0.4 0.39 10.6 0.0 2.2 2 1 0 2 2 2 0 Phage-related baseplate assembly protein Y_phosphatase PF00102.22 KOO35881.1 - 1.3e-08 34.4 0.0 1.7e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Pkinase PF00069.20 KOO35882.1 - 2.4e-71 239.9 0.1 2.5e-62 210.3 0.0 2.6 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 KOO35882.1 - 4.8e-27 94.6 0.1 2.3e-23 82.5 0.0 2.6 2 0 0 2 2 2 2 Protein tyrosine kinase PCI PF01399.22 KOO35883.1 - 3.4e-13 49.8 0.0 8.3e-13 48.5 0.0 1.7 1 0 0 1 1 1 1 PCI domain Mvb12 PF09452.5 KOO35883.1 - 0.13 12.4 0.1 0.32 11.1 0.1 1.6 1 0 0 1 1 1 0 ESCRT-I subunit Mvb12 Ras PF00071.17 KOO35885.1 - 1.1e-40 138.7 0.0 1.3e-40 138.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO35885.1 - 5.3e-19 68.8 0.0 9.7e-19 68.0 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO35885.1 - 3.7e-10 39.3 0.0 5.6e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 KOO35885.1 - 1.6e-06 27.4 0.0 1.9e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KOO35885.1 - 9.8e-06 25.1 0.0 0.00053 19.4 0.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOO35885.1 - 3.1e-05 23.9 0.0 7.4e-05 22.6 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase YwhD PF08741.5 KOO35885.1 - 0.0039 16.6 0.0 0.0059 16.0 0.0 1.3 1 0 0 1 1 1 1 YwhD family AAA_16 PF13191.1 KOO35885.1 - 0.079 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Imm42 PF15601.1 KOO35885.1 - 0.1 12.0 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 42 Beta_helix PF13229.1 KOO35886.1 - 2e-07 30.9 0.0 3e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Right handed beta helix region Pectate_lyase_3 PF12708.2 KOO35886.1 - 0.0057 16.8 0.0 0.0075 16.4 0.0 1.3 1 0 0 1 1 1 1 Pectate lyase superfamily protein Pectinesterase PF01095.14 KOO35886.1 - 0.014 13.9 0.2 0.03 12.9 0.1 1.4 1 1 0 1 1 1 0 Pectinesterase NosD PF05048.8 KOO35886.1 - 0.05 12.7 0.0 0.066 12.3 0.0 1.1 1 0 0 1 1 1 0 Periplasmic copper-binding protein (NosD) Hydrolase_like PF13242.1 KOO35886.1 - 0.093 12.4 0.1 2.4 7.9 0.0 2.3 2 0 0 2 2 2 0 HAD-hyrolase-like IQ PF00612.22 KOO35889.1 - 0.0078 15.7 1.2 1.1 9.0 0.1 2.7 2 0 0 2 2 2 2 IQ calmodulin-binding motif DUF948 PF06103.6 KOO35889.1 - 0.1 12.4 0.5 0.19 11.5 0.3 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Phage_cap_E PF03864.10 KOO35889.1 - 0.25 10.2 1.3 0.38 9.6 0.9 1.3 1 0 0 1 1 1 0 Phage major capsid protein E ADIP PF11559.3 KOO35889.1 - 0.28 11.0 13.6 0.085 12.7 3.7 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF724 PF05266.9 KOO35889.1 - 4 7.0 12.4 0.38 10.3 3.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Glyco_hydro_16 PF00722.16 KOO35890.1 - 2.4e-07 30.2 0.0 1.6e-06 27.5 0.0 2.2 3 0 0 3 3 3 1 Glycosyl hydrolases family 16 Fe_hyd_lg_C PF02906.9 KOO35891.1 - 2e-48 165.0 0.0 3.4e-48 164.3 0.0 1.3 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Fe_hyd_SSU PF02256.12 KOO35891.1 - 0.0017 18.3 0.0 0.0024 17.8 0.0 1.3 1 0 0 1 1 1 1 Iron hydrogenase small subunit MAAL_C PF07476.6 KOO35892.1 - 0.08 11.8 0.0 0.17 10.8 0.0 1.4 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus Laminin_G_3 PF13385.1 KOO35893.1 - 0.0069 16.6 0.7 0.0088 16.2 0.5 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Beta_helix PF13229.1 KOO35895.1 - 0.0057 16.4 0.2 0.0074 16.0 0.1 1.1 1 0 0 1 1 1 1 Right handed beta helix region ArfGap PF01412.13 KOO35897.1 - 2.1e-25 88.7 0.1 4.8e-25 87.5 0.0 1.7 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Cytochrom_C PF00034.16 KOO35897.1 - 0.02 15.7 1.1 0.29 11.9 0.0 3.0 3 0 0 3 3 3 0 Cytochrome c SpoIIIAH PF12685.2 KOO35897.1 - 0.038 13.5 2.1 0.049 13.1 0.2 1.8 2 0 0 2 2 2 0 SpoIIIAH-like protein LIN37 PF15306.1 KOO35897.1 - 0.09 12.7 1.1 0.16 11.9 0.8 1.4 1 0 0 1 1 1 0 LIN37 HBS1_N PF08938.5 KOO35897.1 - 0.69 10.0 4.0 0.63 10.1 1.2 2.0 2 0 0 2 2 2 0 HBS1 N-terminus Cep57_MT_bd PF06657.8 KOO35898.1 - 0.034 14.0 7.0 0.24 11.3 0.4 2.5 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF1700 PF08006.6 KOO35898.1 - 0.037 13.3 0.1 0.054 12.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) DUF607 PF04678.8 KOO35898.1 - 0.043 13.7 0.2 0.065 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF607 Spc7 PF08317.6 KOO35898.1 - 0.049 12.2 3.3 0.066 11.8 2.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4252 PF14060.1 KOO35898.1 - 0.079 12.5 0.9 0.1 12.1 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) Dna2 PF08696.6 KOO35898.1 - 0.11 11.7 0.1 0.13 11.5 0.1 1.2 1 0 0 1 1 1 0 DNA replication factor Dna2 Baculo_PEP_C PF04513.7 KOO35898.1 - 0.11 12.2 4.3 0.17 11.7 3.0 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4191 PF13829.1 KOO35898.1 - 0.16 11.0 0.5 0.24 10.4 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) KfrA_N PF11740.3 KOO35898.1 - 0.18 12.2 6.8 0.3 11.5 4.7 1.4 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term CCDC-167 PF15188.1 KOO35898.1 - 0.28 11.1 3.8 0.36 10.7 1.0 2.0 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 IncA PF04156.9 KOO35898.1 - 0.44 10.1 9.3 0.94 9.0 6.4 1.5 1 0 0 1 1 1 0 IncA protein OmpH PF03938.9 KOO35898.1 - 0.68 9.8 6.3 0.87 9.5 4.4 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF2309 PF10070.4 KOO35903.1 - 1.2e-124 417.2 0.0 1.4e-124 417.0 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2309) Cpn60_TCP1 PF00118.19 KOO35905.1 - 5.7e-138 460.5 6.2 6.5e-138 460.3 4.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF4336 PF14234.1 KOO35906.1 - 6.6e-74 248.6 0.0 9.7e-74 248.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4336) VRR_NUC PF08774.6 KOO35906.1 - 4.5e-15 55.5 0.0 8.3e-15 54.6 0.0 1.5 1 0 0 1 1 1 1 VRR-NUC domain PAPS_reduct PF01507.14 KOO35907.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family CH PF00307.26 KOO35908.1 - 1.9e-33 114.7 0.3 3.7e-18 65.5 0.0 2.8 3 0 0 3 3 3 2 Calponin homology (CH) domain CAMSAP_CH PF11971.3 KOO35908.1 - 9.7e-13 47.5 0.0 2.8e-08 33.2 0.0 2.5 2 0 0 2 2 2 2 CAMSAP CH domain Spectrin PF00435.16 KOO35908.1 - 0.037 14.2 0.5 8.2 6.7 0.1 2.9 2 0 0 2 2 2 0 Spectrin repeat DUF4044 PF13253.1 KOO35908.1 - 0.27 10.4 0.8 0.68 9.1 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4044) Phage_integrase PF00589.17 KOO35909.1 - 1.2e-05 25.0 0.0 0.00049 19.8 0.0 2.4 2 0 0 2 2 2 2 Phage integrase family SHIPPO-rpt PF07004.7 KOO35910.1 - 0.12 13.3 4.1 1.5 9.8 0.1 4.0 2 0 0 2 2 2 0 Sperm-tail PG-rich repeat Kelch_3 PF13415.1 KOO35910.1 - 0.17 12.0 1.5 0.74 10.0 1.1 2.1 1 0 0 1 1 1 0 Galactose oxidase, central domain zf-H2C2_2 PF13465.1 KOO35911.1 - 8e-36 120.5 41.6 1.5e-05 25.0 0.1 8.6 8 0 0 8 8 8 7 Zinc-finger double domain zf-C2H2 PF00096.21 KOO35911.1 - 8.7e-13 47.7 42.5 0.13 12.6 0.7 7.6 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOO35911.1 - 9e-09 35.0 38.0 0.17 12.2 0.0 7.6 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2_6 PF13912.1 KOO35911.1 - 1.3e-06 28.0 18.8 1.3 9.0 0.3 7.3 7 0 0 7 7 7 3 C2H2-type zinc finger OTU PF02338.14 KOO35911.1 - 3.9e-06 27.4 0.0 1.3e-05 25.7 0.0 1.9 1 1 0 1 1 1 1 OTU-like cysteine protease zf-C2H2_jaz PF12171.3 KOO35911.1 - 0.0034 17.4 8.0 8.7 6.6 0.0 5.5 6 0 0 6 6 6 1 Zinc-finger double-stranded RNA-binding MTBP_mid PF14919.1 KOO35912.1 - 0.0029 16.3 2.8 2.3 6.8 0.0 3.5 1 1 3 4 4 4 3 MDM2-binding Pilus_CpaD PF09476.5 KOO35912.1 - 0.25 10.7 13.0 0.5 9.8 1.5 2.6 1 1 2 3 3 3 0 Pilus biogenesis CpaD protein (pilus_cpaD) zf-His_Me_endon PF05551.6 KOO35912.1 - 0.47 10.4 2.1 63 3.5 0.0 3.0 1 1 1 3 3 3 0 Zinc-binding loop region of homing endonuclease T2SM_b PF10741.4 KOO35912.1 - 0.51 9.9 17.8 16 5.1 0.2 6.1 1 1 6 7 7 7 0 Type II secretion system (T2SS), protein M subtype b DUF1160 PF06648.6 KOO35913.1 - 0.017 14.8 0.1 0.035 13.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1160) MASE1 PF05231.9 KOO35914.1 - 0.017 14.1 4.0 0.021 13.8 2.8 1.1 1 0 0 1 1 1 0 MASE1 Apolipoprotein PF01442.13 KOO35915.1 - 0.26 10.7 15.5 0.64 9.4 7.3 2.9 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain HTH_40 PF14493.1 KOO35915.1 - 0.28 11.4 4.5 0.2 11.8 0.3 2.7 3 1 1 4 4 4 0 Helix-turn-helix domain 2OG-FeII_Oxy_3 PF13640.1 KOO35917.1 - 0.0054 17.2 0.2 0.011 16.1 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO35917.1 - 0.0079 16.4 0.0 0.017 15.4 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Oxygenase-NA PF09859.4 KOO35917.1 - 0.12 11.6 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Oxygenase, catalysing oxidative methylation of damaged DNA zf-DNL PF05180.7 KOO35918.1 - 0.19 11.4 1.0 3.7 7.3 0.0 2.3 2 0 0 2 2 2 0 DNL zinc finger PepSY_2 PF13670.1 KOO35919.1 - 0.038 13.8 1.1 0.061 13.2 0.8 1.3 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain EF-hand_6 PF13405.1 KOO35921.1 - 0.0018 17.9 0.2 0.19 11.7 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 KOO35921.1 - 0.0028 16.8 1.5 0.05 12.9 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO35921.1 - 0.045 13.8 0.1 0.23 11.6 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain pair Form_Nir_trans PF01226.12 KOO35922.1 - 4e-62 209.3 18.9 4.5e-62 209.1 13.1 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter MFS_1 PF07690.11 KOO35923.1 - 5.6e-10 38.4 75.6 2.6e-08 33.0 35.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Pga1 PF10333.4 KOO35924.1 - 0.6 9.7 2.7 20 4.7 0.2 2.6 1 1 2 3 3 3 0 GPI-Mannosyltransferase II co-activator LMBR1 PF04791.11 KOO35924.1 - 2 6.9 8.7 5.5 5.4 6.0 1.8 1 1 0 1 1 1 0 LMBR1-like membrane protein DivIC PF04977.10 KOO35924.1 - 3.7 7.0 37.9 0.41 10.1 3.5 4.7 1 1 4 5 5 5 0 Septum formation initiator DUF4281 PF14108.1 KOO35925.1 - 8.2e-31 106.7 0.8 9.6e-31 106.5 0.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4281) Pkinase PF00069.20 KOO35926.1 - 1.2e-43 149.2 0.0 1.5e-43 148.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO35926.1 - 4.3e-19 68.5 0.0 5.8e-19 68.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO35926.1 - 0.037 12.9 0.0 0.072 12.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like RPAP3_C PF13877.1 KOO35926.1 - 0.04 13.8 0.0 0.083 12.8 0.0 1.5 1 0 0 1 1 1 0 Potential Monad-binding region of RPAP3 Herpes_UL33 PF03581.8 KOO35928.1 - 0.092 12.6 2.4 0.28 11.1 0.3 2.7 2 0 0 2 2 2 0 Herpesvirus UL33-like protein DUF4201 PF13870.1 KOO35929.1 - 0.0083 15.5 9.0 0.0095 15.3 5.0 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF4201) DUF3584 PF12128.3 KOO35929.1 - 0.018 12.4 9.6 0.022 12.1 6.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF3259 PF11652.3 KOO35929.1 - 0.12 12.5 1.5 0.15 12.2 0.3 1.7 1 1 0 2 2 2 0 Protein of unknown function (DUF3259) ADIP PF11559.3 KOO35929.1 - 0.72 9.7 11.0 0.051 13.4 3.3 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding AAA_13 PF13166.1 KOO35929.1 - 0.76 8.1 4.1 0.41 9.0 0.3 1.6 1 1 0 1 1 1 0 AAA domain APG6 PF04111.7 KOO35929.1 - 1.1 8.2 12.8 1.5 7.7 8.9 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Peptidase_S46 PF10459.4 KOO35929.1 - 1.6 7.0 8.5 2.1 6.6 5.9 1.0 1 0 0 1 1 1 0 Peptidase S46 Mnd1 PF03962.10 KOO35929.1 - 2.7 7.6 7.7 3.8 7.1 5.3 1.3 1 0 0 1 1 1 0 Mnd1 family DUF972 PF06156.8 KOO35929.1 - 3 8.2 7.2 2.9 8.2 2.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Exonuc_VII_L PF02601.10 KOO35929.1 - 3.5 6.7 7.2 4.2 6.4 5.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4200 PF13863.1 KOO35929.1 - 8 6.4 18.5 20 5.1 8.8 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4200) DUF4098 PF13345.1 KOO35931.1 - 2.6e-08 33.7 10.4 2.5e-05 24.1 0.3 3.6 1 1 2 3 3 3 3 Domain of unknown function (DUF4098) DUF2807 PF10988.3 KOO35931.1 - 0.0023 17.5 5.7 0.037 13.5 2.7 2.7 1 1 1 2 2 2 1 Protein of unknown function (DUF2807) Chorion_1 PF01723.11 KOO35931.1 - 0.35 10.7 11.6 0.091 12.6 1.4 2.3 1 1 1 2 2 2 0 Chorion protein Apc3 PF12895.2 KOO35932.1 - 0.0016 18.5 2.0 0.11 12.6 0.1 3.3 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.23 KOO35932.1 - 0.0038 16.7 0.1 8.2 6.2 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO35932.1 - 0.0056 16.9 12.4 0.44 10.9 0.0 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat SPO22 PF08631.5 KOO35932.1 - 0.13 11.3 2.3 1.2 8.1 0.0 3.2 3 1 1 4 4 4 0 Meiosis protein SPO22/ZIP4 like TPR_14 PF13428.1 KOO35932.1 - 1.2 10.0 0.0 1.2 10.0 0.0 8.9 7 3 3 10 10 10 0 Tetratricopeptide repeat Profilin PF00235.14 KOO35933.1 - 3.3e-32 111.1 0.1 3.7e-32 110.9 0.1 1.0 1 0 0 1 1 1 1 Profilin cNMP_binding PF00027.24 KOO35934.1 - 1.2e-08 34.5 0.0 0.0023 17.7 0.0 3.0 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain Peptidase_S51 PF03575.12 KOO35934.1 - 0.022 14.4 0.0 0.04 13.6 0.0 1.3 1 0 0 1 1 1 0 Peptidase family S51 Nefa_Nip30_N PF10187.4 KOO35935.1 - 3.9e-12 46.2 9.6 6.4e-12 45.5 6.7 1.3 1 0 0 1 1 1 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 DUF4316 PF14195.1 KOO35935.1 - 0.15 12.1 2.3 0.12 12.4 0.4 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4316) Rubis-subs-bind PF09273.6 KOO35936.1 - 4.9e-23 81.4 0.5 1.4e-22 79.9 0.2 2.0 2 0 0 2 2 2 1 Rubisco LSMT substrate-binding SET PF00856.23 KOO35936.1 - 2.2e-12 47.5 0.0 5e-12 46.4 0.0 1.6 1 1 0 1 1 1 1 SET domain Ufd2P_core PF10408.4 KOO35937.1 - 8.2e-141 470.3 0.0 1.1e-140 469.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.10 KOO35937.1 - 3.6e-27 94.1 0.1 7.6e-27 93.0 0.1 1.6 1 0 0 1 1 1 1 U-box domain PBC PF03792.8 KOO35937.1 - 0.2 11.2 2.5 7.3 6.2 0.1 3.1 2 1 1 3 3 3 0 PBC domain DAGAT PF03982.8 KOO35939.1 - 1.4e-23 83.0 0.0 2.1e-23 82.4 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Acyltransferase PF01553.16 KOO35939.1 - 0.044 13.2 0.0 0.077 12.4 0.0 1.3 1 0 0 1 1 1 0 Acyltransferase AtpR PF12966.2 KOO35939.1 - 0.83 9.8 4.6 5.9 7.1 0.3 2.8 2 1 0 3 3 3 0 N-ATPase, AtpR subunit TylF PF05711.6 KOO35940.1 - 2.9e-29 101.8 0.0 3.7e-20 72.0 0.0 2.0 1 1 1 2 2 2 2 Macrocin-O-methyltransferase (TylF) Methyltransf_24 PF13578.1 KOO35940.1 - 1.2e-05 26.0 0.0 2.2e-05 25.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain EF-hand_7 PF13499.1 KOO35941.1 - 5.5e-07 29.6 0.0 6.7e-06 26.1 0.0 2.7 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO35941.1 - 0.0007 19.2 1.0 0.1 12.5 0.0 3.1 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.27 KOO35941.1 - 0.0036 16.4 0.2 0.048 12.9 0.0 2.9 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.1 KOO35941.1 - 0.016 14.5 0.0 0.076 12.3 0.0 2.2 1 0 0 1 1 1 0 EF hand Peptidase_S8 PF00082.17 KOO35942.1 - 2.9e-30 105.3 0.9 4.7e-30 104.7 0.6 1.2 1 0 0 1 1 1 1 Subtilase family Phage_tail_S PF05069.8 KOO35944.1 - 0.0065 16.2 0.6 0.0099 15.6 0.4 1.3 1 0 0 1 1 1 1 Phage virion morphogenesis family USP8_dimer PF08969.6 KOO35947.1 - 7.7e-13 48.4 0.0 1.2e-12 47.8 0.0 1.3 1 1 0 1 1 1 1 USP8 dimerisation domain NAP PF00956.13 KOO35948.1 - 2.5e-56 190.5 2.5 2.5e-56 190.5 1.8 1.4 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) SbcCD_C PF13558.1 KOO35948.1 - 0.0055 16.5 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit DUF848 PF05852.6 KOO35948.1 - 0.011 15.6 2.0 0.02 14.7 1.4 1.4 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) BTV_NS2 PF04514.7 KOO35948.1 - 0.016 14.0 1.3 0.03 13.2 0.9 1.4 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 TBPIP PF07106.8 KOO35948.1 - 0.063 12.8 3.3 0.14 11.6 2.3 1.5 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DMAP_binding PF06464.6 KOO35948.1 - 0.1 13.2 2.8 1.2 9.8 1.0 2.6 2 0 0 2 2 2 0 DMAP1-binding Domain bZIP_1 PF00170.16 KOO35948.1 - 0.28 11.1 6.5 0.13 12.2 2.2 2.1 2 0 0 2 2 2 0 bZIP transcription factor Aldo_ket_red PF00248.16 KOO35949.1 - 4.3e-19 68.4 0.0 6e-19 67.9 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Coiled PF05710.7 KOO35949.1 - 0.055 13.9 4.6 0.08 13.4 0.2 2.5 2 0 0 2 2 2 0 Coiled coil PRRSV_Env PF02340.10 KOO35949.1 - 0.17 11.0 1.3 0.66 9.0 0.9 1.9 2 0 0 2 2 2 0 PRRSV putative envelope protein DUF2828 PF11443.3 KOO35950.1 - 4.7e-36 124.1 0.0 1.4e-23 82.9 0.0 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF2828) Y_phosphatase3C PF13348.1 KOO35951.1 - 0.26 11.4 1.4 1.4 9.1 0.0 2.6 3 0 0 3 3 3 0 Tyrosine phosphatase family C-terminal region LRR_4 PF12799.2 KOO35952.1 - 8.2e-17 60.4 15.4 1.6e-05 24.4 0.1 7.9 4 2 5 9 9 9 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO35952.1 - 5.7e-13 48.4 10.8 4.4e-07 29.5 1.2 4.6 4 2 2 6 6 6 4 Leucine rich repeat LRR_1 PF00560.28 KOO35952.1 - 3.5e-12 44.5 11.4 0.045 13.7 0.1 9.1 10 0 0 10 10 10 2 Leucine Rich Repeat LRR_6 PF13516.1 KOO35952.1 - 5.4e-05 22.8 13.6 0.4 10.8 0.1 6.5 7 0 0 7 7 7 2 Leucine Rich repeat LRR_7 PF13504.1 KOO35952.1 - 0.00051 19.8 6.1 44 4.9 0.0 7.2 8 0 0 8 8 8 0 Leucine rich repeat Kelch_5 PF13854.1 KOO35953.1 - 3.1e-23 81.2 0.0 0.0027 17.5 0.0 6.6 6 1 0 6 6 6 6 Kelch motif Kelch_4 PF13418.1 KOO35953.1 - 6e-21 73.9 3.9 0.0043 16.7 0.1 6.7 7 0 0 7 7 6 5 Galactose oxidase, central domain Kelch_3 PF13415.1 KOO35953.1 - 8.9e-21 73.4 17.1 0.0014 18.7 0.4 6.9 7 0 0 7 7 7 5 Galactose oxidase, central domain TPR_11 PF13414.1 KOO35953.1 - 8.6e-18 63.7 9.4 2.7e-13 49.3 0.9 2.4 2 0 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 KOO35953.1 - 1.9e-13 49.2 4.3 1.9e-05 24.1 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO35953.1 - 5.3e-12 44.8 2.5 0.00026 20.4 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat Kelch_2 PF07646.10 KOO35953.1 - 1.3e-09 37.4 0.0 0.31 10.8 0.0 5.9 6 0 0 6 6 6 2 Kelch motif Kelch_6 PF13964.1 KOO35953.1 - 9.1e-08 31.9 0.0 5.9 7.2 0.0 6.0 6 0 0 6 6 6 2 Kelch motif TPR_16 PF13432.1 KOO35953.1 - 1.2e-06 28.9 12.7 6.8e-05 23.4 4.1 3.9 3 1 1 4 4 3 2 Tetratricopeptide repeat Kelch_1 PF01344.20 KOO35953.1 - 2.3e-05 23.8 0.0 35 4.0 0.0 6.4 7 0 0 7 7 7 0 Kelch motif TPR_17 PF13431.1 KOO35953.1 - 0.0001 22.2 1.4 0.58 10.5 0.2 3.4 4 0 0 4 4 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO35953.1 - 0.00027 21.2 1.0 0.00027 21.2 0.7 4.5 1 1 3 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 KOO35953.1 - 0.0023 18.2 16.5 0.01 16.1 1.3 2.9 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO35953.1 - 0.0047 16.6 0.2 3.3 7.7 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOO35953.1 - 0.0068 16.3 5.5 0.89 9.5 1.2 2.6 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO35953.1 - 0.015 15.0 0.2 0.23 11.3 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO35953.1 - 0.024 14.4 6.0 0.78 9.6 1.3 3.3 1 1 2 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.12 KOO35953.1 - 3.3 7.9 14.5 0.64 10.3 4.3 3.3 1 1 1 2 2 2 0 Bacterial transcriptional activator domain TPR_10 PF13374.1 KOO35953.1 - 8.5 6.4 9.0 5.5 7.0 0.5 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat ARL2_Bind_BART PF11527.3 KOO35954.1 - 1.6e-07 31.1 0.0 2.4e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART LRR_6 PF13516.1 KOO35955.1 - 5.7e-08 32.0 0.1 4.1 7.7 0.0 5.2 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.2 KOO35955.1 - 0.00074 19.0 0.0 0.076 12.6 0.1 3.2 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO35955.1 - 0.013 15.4 0.0 1.2e+02 3.3 0.0 4.1 4 1 0 4 4 4 0 Leucine Rich Repeat LRR_8 PF13855.1 KOO35955.1 - 0.015 14.9 0.1 1.2 8.9 0.1 2.6 2 1 1 3 3 3 0 Leucine rich repeat LRR_7 PF13504.1 KOO35955.1 - 0.054 13.7 2.4 43 4.9 0.0 4.5 4 1 0 4 4 4 0 Leucine rich repeat TMEM237 PF15383.1 KOO35956.1 - 0.033 13.3 1.7 0.076 12.1 0.1 1.9 2 0 0 2 2 2 0 Transmembrane protein 237 COG2 PF06148.6 KOO35957.1 - 0.0021 17.9 4.2 0.0076 16.1 2.3 2.0 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 TBCA PF02970.11 KOO35957.1 - 0.075 13.1 5.9 0.25 11.4 3.2 2.1 2 0 0 2 2 2 0 Tubulin binding cofactor A TMF_DNA_bd PF12329.3 KOO35957.1 - 0.13 12.0 12.5 0.29 10.9 7.7 2.2 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding YlqD PF11068.3 KOO35957.1 - 0.25 11.3 4.7 0.45 10.5 3.2 1.4 1 0 0 1 1 1 0 YlqD protein DUF2229 PF09989.4 KOO35957.1 - 0.25 10.7 3.0 0.33 10.3 2.1 1.2 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) Tropomyosin PF00261.15 KOO35957.1 - 0.32 10.0 16.9 0.23 10.4 10.6 1.7 1 1 0 1 1 1 0 Tropomyosin XhlA PF10779.4 KOO35957.1 - 0.78 9.7 5.0 1.6 8.6 2.0 2.2 1 1 1 2 2 2 0 Haemolysin XhlA DUF4140 PF13600.1 KOO35957.1 - 1.1 9.6 14.8 1.4 9.3 7.1 2.5 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Exonuc_VII_S PF02609.11 KOO35957.1 - 2.4 8.0 5.3 12 5.7 0.9 3.5 3 1 0 3 3 3 0 Exonuclease VII small subunit WXG100 PF06013.7 KOO35957.1 - 2.4 8.2 12.4 1.3e+02 2.6 0.0 3.0 2 1 0 2 2 2 0 Proteins of 100 residues with WXG TPR_MLP1_2 PF07926.7 KOO35957.1 - 2.5 7.8 14.6 24 4.6 10.1 2.1 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein RIC3 PF15361.1 KOO35957.1 - 3.4 7.9 5.1 5.9 7.1 1.2 2.2 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 HR1 PF02185.11 KOO35957.1 - 4 7.2 9.8 19 5.1 4.5 2.9 2 1 1 3 3 3 0 Hr1 repeat IncA PF04156.9 KOO35957.1 - 5.7 6.4 13.4 17 4.9 9.3 1.8 1 1 0 1 1 1 0 IncA protein GrpE PF01025.14 KOO35957.1 - 8.8 5.8 11.1 7.4 6.0 6.8 1.5 1 1 0 1 1 1 0 GrpE DEAD PF00270.24 KOO35958.1 - 8.8e-06 25.3 3.1 0.022 14.2 0.1 2.4 1 1 1 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.10 KOO35958.1 - 0.0072 16.1 3.6 0.4 10.4 0.0 2.6 2 1 1 3 3 3 2 Type III restriction enzyme, res subunit AAA_19 PF13245.1 KOO35958.1 - 0.011 15.4 3.0 2.2 8.1 0.1 2.8 2 0 0 2 2 2 0 Part of AAA domain T2SE PF00437.15 KOO35958.1 - 0.033 13.0 3.3 2.9 6.7 1.1 2.2 1 1 1 2 2 2 0 Type II/IV secretion system protein AAA_24 PF13479.1 KOO35958.1 - 2.2 7.8 5.3 2 7.9 0.1 2.2 1 1 1 2 2 2 0 AAA domain Chloroa_b-bind PF00504.16 KOO35960.1 - 1.6e-30 106.3 0.1 2.3e-30 105.9 0.1 1.2 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Sulfotransfer_3 PF13469.1 KOO35961.1 - 1.7e-19 71.2 3.2 1.7e-19 71.2 2.2 1.8 2 0 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.22 KOO35961.1 - 8.7e-06 25.1 0.0 7.4e-05 22.1 0.0 2.0 1 1 0 1 1 1 1 Sulfotransferase domain Sulphotransf PF09037.5 KOO35961.1 - 0.0017 17.8 0.0 0.44 10.0 0.0 3.0 2 1 0 2 2 2 2 Stf0 sulphotransferase CaATP_NAI PF12515.3 KOO35961.1 - 0.18 11.3 2.2 0.53 9.8 0.0 2.2 2 0 0 2 2 2 0 Ca2+-ATPase N terminal autoinhibitory domain Chloroa_b-bind PF00504.16 KOO35962.1 - 6.5e-33 114.1 0.1 7.5e-33 113.9 0.1 1.0 1 0 0 1 1 1 1 Chlorophyll A-B binding protein EF-hand_5 PF13202.1 KOO35963.1 - 2.7e-07 29.6 4.3 0.00041 19.5 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_1 PF00036.27 KOO35963.1 - 9.9e-06 24.5 1.0 0.0057 15.8 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 KOO35963.1 - 1.6e-05 24.9 0.8 6.2e-05 23.0 0.1 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO35963.1 - 2.4e-05 23.8 1.2 0.13 12.1 0.0 2.6 2 1 1 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 KOO35963.1 - 0.0016 17.9 1.3 0.014 15.0 0.0 2.3 2 1 0 2 2 2 1 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO35963.1 - 0.0026 17.7 0.1 0.61 10.1 0.0 2.5 1 1 1 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_1 PF00036.27 KOO35964.1 - 2.8e-07 29.3 0.0 0.0047 16.1 0.0 2.5 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.1 KOO35964.1 - 1.2e-06 28.5 0.2 6.9e-05 22.9 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO35964.1 - 1e-05 25.0 0.0 0.0058 16.2 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO35964.1 - 1.2e-05 24.8 0.1 0.033 14.0 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO35964.1 - 0.0014 17.8 0.3 0.36 10.2 0.0 2.7 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.4 KOO35964.1 - 0.0054 16.7 0.0 0.03 14.3 0.0 2.0 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region DUF1073 PF06381.6 KOO35964.1 - 0.088 11.2 0.0 0.13 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1073) CTD_bind PF04818.8 KOO35965.1 - 5.7e-06 26.4 0.0 1.2e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase II-binding domain. DUF2514 PF10721.4 KOO35965.1 - 0.03 14.0 6.7 0.07 12.8 4.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) Pro_isomerase PF00160.16 KOO35966.1 - 1.6e-44 151.8 0.0 2.3e-44 151.3 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD FKBP_C PF00254.23 KOO35966.1 - 3.3e-21 75.0 0.0 7.2e-21 74.0 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.13 KOO35966.1 - 4e-06 26.8 0.0 1.1e-05 25.4 0.0 1.7 2 0 0 2 2 2 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Mg_trans_NIPA PF05653.9 KOO35967.1 - 1.8e-10 40.2 11.3 2.5e-10 39.8 7.8 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.15 KOO35967.1 - 0.0072 16.3 2.7 0.0072 16.3 1.9 3.5 2 1 1 3 3 3 1 EamA-like transporter family RNase_PH PF01138.16 KOO35969.1 - 7.4e-19 68.3 0.1 7.4e-19 68.3 0.0 1.5 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 Aminotran_1_2 PF00155.16 KOO35970.1 - 2.4e-36 125.4 0.0 3.1e-36 125.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 KOO35970.1 - 5.3e-06 25.7 0.0 9.6e-06 24.9 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase PX PF00787.19 KOO35970.1 - 7.7e-06 25.6 0.0 1.4e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 PX domain Alliinase_C PF04864.8 KOO35970.1 - 0.025 13.2 0.0 0.085 11.4 0.0 1.8 2 0 0 2 2 2 0 Allinase Methyltrans_SAM PF10672.4 KOO35971.1 - 1.4e-14 53.6 0.0 5e-14 51.8 0.0 1.7 1 1 0 1 1 1 1 S-adenosylmethionine-dependent methyltransferase Methyltransf_26 PF13659.1 KOO35971.1 - 5.5e-14 52.2 0.2 1.7e-13 50.5 0.1 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO35971.1 - 7.2e-11 41.9 0.0 1.6e-10 40.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO35971.1 - 2e-10 41.2 0.1 3.7e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 KOO35971.1 - 9.8e-07 28.1 0.0 1.4e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.13 KOO35971.1 - 3.4e-06 26.7 0.1 2.3e-05 24.0 0.0 2.0 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 MTS PF05175.9 KOO35971.1 - 2.3e-05 23.8 0.0 0.00036 19.9 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Cons_hypoth95 PF03602.10 KOO35971.1 - 2.3e-05 23.8 0.4 0.00013 21.4 0.3 2.1 1 1 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.1 KOO35971.1 - 2.8e-05 24.4 0.0 6.4e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 KOO35971.1 - 0.00016 21.3 0.0 0.00024 20.7 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_15 PF09445.5 KOO35971.1 - 0.00021 20.9 0.0 0.00034 20.2 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase FtsJ PF01728.14 KOO35971.1 - 0.0024 17.8 0.0 0.0041 17.1 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.1 KOO35971.1 - 0.022 14.4 0.0 0.054 13.2 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.7 KOO35971.1 - 0.14 12.6 0.1 2.2 8.8 0.0 2.6 3 0 0 3 3 3 0 Methyltransferase domain PhyH PF05721.8 KOO35972.1 - 1.2e-14 54.9 0.1 2e-14 54.1 0.1 1.4 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.1 KOO35972.1 - 0.00095 19.4 0.0 0.002 18.4 0.0 1.5 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase VCBS PF13517.1 KOO35974.1 - 9e-134 435.9 152.6 2.1e-14 53.5 4.1 12.6 1 1 12 13 13 13 13 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO35974.1 - 5.4e-72 236.0 120.0 2.9e-06 26.7 0.4 13.4 13 0 0 13 13 13 13 FG-GAP repeat Pkinase PF00069.20 KOO35974.1 - 1.1e-29 103.3 0.0 3.7e-15 55.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain TcdB_toxin_midN PF12256.3 KOO35974.1 - 4.3e-29 101.1 45.8 0.16 11.4 0.1 13.1 2 2 11 13 13 13 13 Insecticide toxin TcdB middle/N-terminal region Pkinase_Tyr PF07714.12 KOO35974.1 - 1.1e-26 93.5 0.0 1.3e-26 93.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Arrestin_N PF00339.24 KOO35974.1 - 0.017 14.9 0.0 20 4.9 0.0 5.1 7 0 0 7 7 7 0 Arrestin (or S-antigen), N-terminal domain PGG PF13962.1 KOO35974.1 - 0.47 10.0 4.6 4.8 6.8 0.0 4.6 6 0 0 6 6 6 0 Domain of unknown function BBS2_Mid PF14783.1 KOO35974.1 - 1.5 8.6 15.1 77 3.1 0.0 8.8 13 0 0 13 13 13 0 Ciliary BBSome complex subunit 2, middle region Viral_NABP PF05515.6 KOO35975.1 - 0.15 12.3 0.0 0.34 11.2 0.0 1.5 1 0 0 1 1 1 0 Viral nucleic acid binding PIF1 PF05970.9 KOO35976.1 - 6.2e-08 31.9 0.7 8e-07 28.3 0.1 2.5 2 1 0 2 2 2 1 PIF1-like helicase AAA_30 PF13604.1 KOO35976.1 - 2e-05 24.2 10.2 4.3e-05 23.1 0.0 4.3 5 1 0 5 5 5 1 AAA domain SNF2_N PF00176.18 KOO35978.1 - 3.2e-67 226.4 0.1 4.8e-67 225.8 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOO35978.1 - 2.1e-14 53.1 0.0 5.3e-14 51.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.19 KOO35978.1 - 1.6e-10 40.5 0.4 1.6e-10 40.5 0.3 2.9 4 0 0 4 4 4 1 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.10 KOO35978.1 - 7.2e-09 35.7 0.0 1.4e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 KOO35978.1 - 0.00025 20.6 0.0 0.00063 19.2 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2075 PF09848.4 KOO35978.1 - 0.0061 15.5 0.0 0.013 14.5 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.1 KOO35978.1 - 0.053 13.6 0.1 0.5 10.5 0.0 2.7 3 0 0 3 3 3 0 AAA domain PEX-1N PF09262.6 KOO35978.1 - 0.087 12.8 0.1 5.1 7.2 0.0 2.6 2 0 0 2 2 2 0 Peroxisome biogenesis factor 1, N-terminal TIG PF01833.19 KOO35979.1 - 6.9e-86 282.3 33.3 6e-07 29.3 0.0 18.8 18 2 0 18 18 18 15 IPT/TIG domain C2 PF00168.25 KOO35979.1 - 5.4e-31 106.2 0.0 6.4e-16 57.9 0.0 2.4 2 0 0 2 2 2 2 C2 domain Anth_Ig PF05587.8 KOO35979.1 - 3.1e-08 33.4 0.0 0.45 10.3 0.0 6.3 7 0 0 7 7 7 2 Anthrax receptor extracellular domain Qn_am_d_aIII PF09099.5 KOO35979.1 - 0.00036 20.7 7.0 0.3 11.4 0.0 5.6 7 0 0 7 7 7 2 Quinohemoprotein amine dehydrogenase, alpha subunit domain III BNR_2 PF13088.1 KOO35979.1 - 0.024 13.9 0.0 12 5.1 0.0 3.6 2 1 0 2 2 2 0 BNR repeat-like domain BNR PF02012.15 KOO35979.1 - 0.41 10.6 20.3 2.9 8.0 0.0 6.4 6 0 0 6 6 6 0 BNR/Asp-box repeat Chordopox_A33R PF05966.7 KOO35979.1 - 2 7.1 0.1 3.4 6.4 0.0 1.2 1 0 0 1 1 1 0 Chordopoxvirus A33R protein DUF1561 PF07598.6 KOO35979.1 - 7 4.4 0.0 23 2.7 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1561) Acetyltransf_1 PF00583.19 KOO35982.1 - 0.0014 18.6 0.0 0.0025 17.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 KOO35982.1 - 0.017 15.2 0.1 0.037 14.1 0.1 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 KOO35982.1 - 0.034 13.9 0.0 0.058 13.2 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 KOO35982.1 - 0.043 13.9 0.0 0.079 13.1 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 KOO35982.1 - 0.045 13.6 0.0 0.096 12.5 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase LRR_6 PF13516.1 KOO35983.1 - 1.4e-14 52.4 4.0 0.0026 17.6 0.4 4.4 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.2 KOO35983.1 - 5.2e-06 25.9 2.4 0.0025 17.3 0.0 3.3 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO35983.1 - 0.00011 21.7 0.8 6.7 7.1 0.0 4.8 4 1 1 5 5 5 1 Leucine Rich Repeat LRR_7 PF13504.1 KOO35983.1 - 0.0016 18.3 0.4 26 5.5 0.0 4.6 4 0 0 4 4 4 0 Leucine rich repeat LRR_8 PF13855.1 KOO35983.1 - 0.21 11.3 6.8 0.69 9.7 0.4 3.4 2 1 0 2 2 2 0 Leucine rich repeat Borrelia_P83 PF05262.6 KOO35983.1 - 0.92 7.7 22.3 1.3 7.2 15.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Peptidase_C6 PF00851.13 KOO35983.1 - 5.5 5.5 9.3 8.4 4.8 6.4 1.3 1 0 0 1 1 1 0 Helper component proteinase Proteasom_PSMB PF10508.4 KOO35984.1 - 0.026 12.7 0.3 0.026 12.7 0.2 1.8 2 0 0 2 2 2 0 Proteasome non-ATPase 26S subunit TM2 PF05154.11 KOO35985.1 - 7.7e-09 35.6 3.3 7.7e-09 35.6 2.3 2.1 3 0 0 3 3 3 1 TM2 domain DEAD PF00270.24 KOO35986.1 - 2.6e-39 134.3 0.0 7.3e-39 132.9 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO35986.1 - 4.6e-22 77.6 0.0 1.3e-21 76.2 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DFP PF04127.10 KOO35986.1 - 0.039 13.5 0.1 5.3 6.6 0.0 2.5 2 0 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein LETM1 PF07766.8 KOO35987.1 - 5.5e-15 55.1 2.5 2.5e-14 52.9 0.2 2.3 2 0 0 2 2 2 2 LETM1-like protein DDHD PF02862.12 KOO35989.1 - 1.1e-28 100.6 0.7 4.1e-13 49.6 0.0 2.2 2 0 0 2 2 2 2 DDHD domain Abhydrolase_5 PF12695.2 KOO35989.1 - 0.00064 19.4 1.2 0.0037 17.0 0.8 2.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Anoctamin PF04547.7 KOO35990.1 - 3.2e-52 177.6 0.0 1.2e-50 172.5 0.0 2.3 1 1 0 1 1 1 1 Calcium-activated chloride channel Ank_2 PF12796.2 KOO35990.1 - 7.7e-17 61.4 1.0 1.4e-08 34.9 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO35990.1 - 2.9e-14 52.0 0.2 5.7e-07 29.0 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.1 KOO35990.1 - 1.1e-13 51.2 0.0 4.9e-08 33.2 0.0 3.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO35990.1 - 1.5e-13 50.4 0.1 1.4e-05 25.1 0.0 3.8 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Choline_transpo PF04515.7 KOO35990.1 - 3.8e-11 42.3 22.0 1.3e-07 30.7 0.7 3.7 4 0 0 4 4 4 2 Plasma-membrane choline transporter Ank_3 PF13606.1 KOO35990.1 - 4.6e-08 32.5 0.1 0.00055 19.9 0.0 4.0 3 0 0 3 3 3 1 Ankyrin repeat Methyltransf_23 PF13489.1 KOO35991.1 - 0.018 14.7 0.0 0.021 14.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.4 KOO35991.1 - 0.02 14.3 0.0 0.03 13.7 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase KASH PF10541.4 KOO35991.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Nuclear envelope localisation domain Ank_2 PF12796.2 KOO35992.1 - 7.1e-87 285.8 37.1 2.2e-13 50.3 0.6 8.4 1 1 7 8 8 8 7 Ankyrin repeats (3 copies) Ank PF00023.25 KOO35992.1 - 4e-62 203.0 66.2 0.00018 21.1 0.2 15.3 15 0 0 15 15 15 14 Ankyrin repeat Ank_4 PF13637.1 KOO35992.1 - 5.5e-62 205.1 18.1 8.7e-09 35.6 0.1 10.1 6 3 5 11 11 11 11 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO35992.1 - 3.3e-56 186.0 45.8 7.9e-08 32.3 0.8 13.1 1 1 13 14 14 14 14 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO35992.1 - 1.2e-29 99.4 22.8 0.0057 16.7 0.0 14.6 14 0 0 14 14 14 7 Ankyrin repeat DUF4182 PF13790.1 KOO35992.1 - 2.2e-09 36.9 13.2 2.6 7.9 0.0 10.6 12 0 0 12 12 12 2 Domain of unknown function (DUF4182) LIN37 PF15306.1 KOO35992.1 - 0.00012 22.0 1.5 12 5.9 0.0 6.4 8 0 0 8 8 8 1 LIN37 ScpA_ScpB PF02616.9 KOO35992.1 - 0.048 13.2 1.4 0.096 12.2 1.0 1.4 1 0 0 1 1 1 0 ScpA/B protein SpoIIIAH PF12685.2 KOO35992.1 - 0.18 11.2 8.5 0.52 9.7 5.9 1.8 1 1 0 1 1 1 0 SpoIIIAH-like protein Phospholip_A2_2 PF05826.7 KOO35992.1 - 5.4 7.0 11.6 1.7 8.6 0.1 4.6 2 2 3 5 5 5 0 Phospholipase A2 PARP PF00644.15 KOO35993.1 - 2.6e-09 36.8 0.0 3.2e-09 36.5 0.0 1.0 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain TAP35_44 PF07265.6 KOO35995.1 - 4.4 7.0 12.2 0.031 14.0 0.8 2.8 1 1 0 2 2 2 0 Tapetum specific protein TAP35/TAP44 MOZ_SAS PF01853.13 KOO35996.1 - 1.1e-20 73.7 0.0 1.3e-20 73.3 0.0 1.1 1 0 0 1 1 1 1 MOZ/SAS family Dimer_Tnp_hAT PF05699.9 KOO35997.1 - 6.7e-05 22.4 0.0 9.3e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Arm PF00514.18 KOO35999.1 - 1.9e-46 154.3 50.5 7.4e-05 22.4 0.0 14.0 14 0 0 14 14 14 13 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO35999.1 - 1e-08 35.3 93.2 0.0031 17.7 3.9 8.3 1 1 9 11 11 11 10 HEAT repeats TRL PF13146.1 KOO35999.1 - 0.23 11.4 29.6 1.1 9.2 0.1 7.3 5 2 3 8 8 8 0 TRL-like protein family HEAT PF02985.17 KOO35999.1 - 1.5 9.1 24.6 78 3.7 0.1 10.4 11 0 0 11 11 11 0 HEAT repeat Clathrin PF00637.15 KOO36000.1 - 2e-11 43.6 0.0 5.2e-11 42.3 0.0 1.7 2 0 0 2 2 2 1 Region in Clathrin and VPS Vps39_1 PF10366.4 KOO36000.1 - 0.13 12.2 0.1 26 4.8 0.0 2.4 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 PPR_3 PF13812.1 KOO36000.1 - 0.3 11.4 3.9 40 4.8 0.0 4.6 4 0 0 4 4 4 0 Pentatricopeptide repeat domain DUF2249 PF10006.4 KOO36000.1 - 1.7 8.3 5.2 1.2 8.7 0.2 3.2 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2249) WD40 PF00400.27 KOO36001.1 - 7.1e-07 28.8 0.2 0.00027 20.7 0.3 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat Glyco_tran_WbsX PF14307.1 KOO36002.1 - 0.00032 19.9 0.0 0.0005 19.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase WbsX Glyco_hydro_71 PF03659.9 KOO36002.1 - 0.0018 16.7 0.0 0.0018 16.7 0.0 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 71 VIT1 PF01988.14 KOO36003.1 - 0.0027 17.2 1.5 16 4.8 0.0 4.2 3 2 1 5 5 5 3 VIT family DUF479 PF04336.7 KOO36003.1 - 0.0036 17.3 1.7 6.4 6.9 0.1 3.8 3 0 0 3 3 3 2 Protein of unknown function, DUF479 DUF2396 PF09654.5 KOO36003.1 - 0.085 12.8 9.8 1.4 8.8 0.3 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2396) FliT PF05400.8 KOO36003.1 - 7.7 7.0 12.7 1e+02 3.4 0.5 6.3 7 1 0 7 7 7 0 Flagellar protein FliT Beta_helix PF13229.1 KOO36004.1 - 1.7e-06 27.9 9.8 2.2e-06 27.5 6.8 1.1 1 0 0 1 1 1 1 Right handed beta helix region NosD PF05048.8 KOO36004.1 - 0.0024 17.0 3.5 0.003 16.7 2.5 1.1 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) Shufflon_N PF04917.7 KOO36004.1 - 0.018 14.1 5.6 0.022 13.8 3.9 1.1 1 0 0 1 1 1 0 Bacterial shufflon protein, N-terminal constant region Glyco_transf_8 PF01501.15 KOO36006.1 - 4.8e-09 35.9 0.0 6.6e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.3 KOO36006.1 - 2.1e-08 33.8 0.0 3.3e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Arabinose_Iso_C PF11762.3 KOO36007.1 - 0.17 11.4 0.7 0.65 9.5 0.0 2.3 2 0 0 2 2 2 0 L-arabinose isomerase C-terminal domain DUF4455 PF14643.1 KOO36008.1 - 1.6e-76 257.8 41.4 1.6e-76 257.8 28.7 3.1 4 0 0 4 4 4 1 Domain of unknown function (DUF4455) DUF4456 PF14644.1 KOO36008.1 - 8.6e-23 80.6 0.1 8.6e-23 80.6 0.0 5.1 5 0 0 5 5 5 2 Domain of unknown function (DUF4456) zf-C3HC4_3 PF13920.1 KOO36009.1 - 3.7e-06 26.5 2.9 9e-06 25.2 2.0 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO36009.1 - 0.00031 20.5 3.0 0.00068 19.4 2.1 1.6 1 1 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 KOO36009.1 - 0.00037 20.1 1.2 0.0007 19.2 0.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 KOO36009.1 - 0.00053 19.9 4.5 0.00087 19.2 0.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Nudix_N_2 PF14803.1 KOO36009.1 - 0.036 13.7 0.8 0.093 12.4 0.6 1.7 1 0 0 1 1 1 0 Nudix N-terminal DUF393 PF04134.7 KOO36009.1 - 0.042 14.9 1.7 0.092 13.8 1.2 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF393 zf-RING_4 PF14570.1 KOO36009.1 - 0.27 10.8 7.0 0.81 9.3 1.8 3.0 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain RCC1 PF00415.13 KOO36010.1 - 1.9e-47 159.2 20.2 1.5e-11 44.3 0.2 8.8 8 1 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO36010.1 - 3.8e-32 109.1 26.0 1.8e-05 24.1 4.1 6.7 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat Arf PF00025.16 KOO36011.1 - 4.9e-77 257.0 0.0 5.8e-77 256.8 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.15 KOO36011.1 - 2.3e-13 49.5 0.2 2.3e-09 36.4 0.0 2.3 1 1 0 2 2 2 2 G-protein alpha subunit SRPRB PF09439.5 KOO36011.1 - 6.7e-12 44.9 0.0 8.2e-12 44.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 KOO36011.1 - 2.3e-11 43.3 0.0 2.6e-11 43.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.7 KOO36011.1 - 3.6e-11 42.6 0.0 4.3e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 KOO36011.1 - 1e-08 35.6 0.0 1.4e-08 35.2 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 KOO36011.1 - 2.2e-07 30.8 0.0 3.4e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 KOO36011.1 - 0.00026 20.4 0.1 0.0073 15.7 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 KOO36011.1 - 0.015 14.6 1.0 0.066 12.4 0.7 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B ArgK PF03308.11 KOO36011.1 - 0.021 13.6 0.2 0.76 8.4 0.0 2.7 2 1 0 2 2 2 0 ArgK protein NID PF07292.8 KOO36011.1 - 0.028 14.4 0.0 4.9 7.2 0.0 2.4 1 1 1 2 2 2 0 Nmi/IFP 35 domain (NID) DUF746 PF05344.6 KOO36011.1 - 0.086 12.3 0.0 0.29 10.6 0.0 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF746) NOG1 PF06858.9 KOO36011.1 - 0.12 12.2 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) AAA_14 PF13173.1 KOO36011.1 - 0.14 12.0 0.4 0.74 9.7 0.3 1.9 1 1 0 1 1 1 0 AAA domain Dimer_Tnp_hAT PF05699.9 KOO36012.1 - 2.5e-15 55.8 0.0 6.2e-14 51.3 0.0 2.2 2 0 0 2 2 2 2 hAT family C-terminal dimerisation region Reticulon PF02453.12 KOO36013.1 - 3.5 7.1 14.2 0.17 11.4 4.4 1.9 1 1 1 2 2 2 0 Reticulon DUF999 PF06198.6 KOO36014.1 - 0.0072 16.1 0.3 0.0079 15.9 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF999) MIF4G PF02854.14 KOO36014.1 - 0.065 12.6 0.3 0.068 12.5 0.2 1.1 1 0 0 1 1 1 0 MIF4G domain Lung_7-TM_R PF06814.8 KOO36014.1 - 0.1 11.5 1.3 0.1 11.5 0.9 1.0 1 0 0 1 1 1 0 Lung seven transmembrane receptor Pkinase PF00069.20 KOO36018.1 - 1.2e-70 237.5 0.0 3.8e-69 232.7 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO36018.1 - 2.1e-38 131.8 0.0 2.7e-37 128.2 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO36018.1 - 0.00055 18.9 0.0 0.00087 18.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOO36018.1 - 0.0083 15.2 0.0 0.014 14.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO36018.1 - 0.012 15.4 0.0 0.33 10.6 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Glyco_trans_1_3 PF13528.1 KOO36019.1 - 1e-09 38.0 0.0 7.8e-06 25.3 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 1 DUF1485 PF07364.7 KOO36019.1 - 0.13 11.4 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1485) UvrC_HhH_N PF08459.6 KOO36019.1 - 0.15 11.5 0.0 0.32 10.5 0.0 1.5 1 0 0 1 1 1 0 UvrC Helix-hairpin-helix N-terminal MerR_1 PF13411.1 KOO36019.1 - 0.55 10.0 2.6 0.98 9.2 0.4 2.3 3 0 0 3 3 3 0 MerR HTH family regulatory protein Methyltransf_21 PF05050.7 KOO36020.1 - 0.027 14.4 0.0 0.041 13.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase FkbM domain Gcd10p PF04189.8 KOO36021.1 - 4.8e-27 94.8 0.0 7.8e-27 94.1 0.0 1.3 1 1 0 1 1 1 1 Gcd10p family AAA_13 PF13166.1 KOO36024.1 - 0.00094 17.7 13.6 0.0014 17.1 9.4 1.2 1 0 0 1 1 1 1 AAA domain Phage_GP20 PF06810.6 KOO36024.1 - 0.0069 15.8 15.5 0.16 11.3 3.3 3.2 2 2 1 3 3 3 2 Phage minor structural protein GP20 DUF3450 PF11932.3 KOO36024.1 - 0.017 14.3 30.3 0.13 11.4 8.7 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) GAS PF13851.1 KOO36024.1 - 0.18 10.9 19.5 0.2 10.8 4.1 2.2 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding MIS13 PF08202.6 KOO36024.1 - 0.3 10.0 5.8 0.063 12.3 0.8 1.9 1 1 0 2 2 2 0 Mis12-Mtw1 protein family DUF2408 PF10303.4 KOO36024.1 - 0.31 11.1 8.3 1.6e+02 2.4 5.6 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) NPV_P10 PF05531.7 KOO36024.1 - 0.44 10.8 4.4 6.7 7.0 0.2 3.2 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.6 KOO36024.1 - 0.64 9.9 4.8 1.5 8.7 0.2 3.1 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Seryl_tRNA_N PF02403.17 KOO36024.1 - 1.2 9.1 24.1 1.5 8.9 1.0 3.3 1 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Prefoldin_2 PF01920.15 KOO36024.1 - 1.3 8.8 18.2 0.72 9.6 0.1 4.3 4 1 0 4 4 4 0 Prefoldin subunit IncA PF04156.9 KOO36024.1 - 2.7 7.5 29.5 0.65 9.5 4.2 3.2 1 1 1 2 2 2 0 IncA protein TMF_TATA_bd PF12325.3 KOO36024.1 - 4.8 6.9 23.5 0.84 9.3 3.6 3.6 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding Filament PF00038.16 KOO36024.1 - 6.2 6.1 32.4 1.9 7.8 3.0 3.4 1 1 2 3 3 3 0 Intermediate filament protein FlxA PF14282.1 KOO36024.1 - 6.7 6.7 16.0 15 5.5 1.8 3.7 2 2 1 3 3 3 0 FlxA-like protein HisKA PF00512.20 KOO36024.1 - 8.9 6.3 16.3 0.35 10.8 0.8 3.6 2 1 1 3 3 3 0 His Kinase A (phospho-acceptor) domain Pkinase PF00069.20 KOO36025.1 - 3.3e-37 128.0 0.0 4.2e-37 127.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO36025.1 - 5e-27 94.6 0.0 6.3e-27 94.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO36025.1 - 0.0011 18.0 0.0 0.0014 17.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOO36025.1 - 0.0063 15.6 0.0 0.016 14.2 0.0 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.11 KOO36025.1 - 0.009 15.9 0.1 0.076 12.9 0.1 2.0 1 1 0 1 1 1 1 ABC1 family RIO1 PF01163.17 KOO36025.1 - 0.021 14.1 0.2 0.034 13.5 0.2 1.5 1 1 0 1 1 1 0 RIO1 family APH PF01636.18 KOO36025.1 - 0.08 12.6 0.0 0.14 11.9 0.0 1.3 1 1 0 1 1 1 0 Phosphotransferase enzyme family UPF0016 PF01169.14 KOO36026.1 - 1.1e-19 70.3 18.2 2.2e-13 50.1 3.8 2.2 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 DUF4131 PF13567.1 KOO36026.1 - 0.68 9.3 6.0 5.3 6.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) YtpI PF14007.1 KOO36026.1 - 1.5 8.8 8.1 10 6.1 0.2 2.9 2 1 1 3 3 3 0 YtpI-like protein STAS_2 PF13466.1 KOO36028.1 - 0.23 11.5 6.4 0.37 10.8 3.1 2.3 1 1 2 3 3 3 0 STAS domain Leo1 PF04004.8 KOO36028.1 - 0.99 9.0 4.0 6.2 6.4 0.4 2.1 2 0 0 2 2 2 0 Leo1-like protein AstE_AspA PF04952.9 KOO36029.1 - 3.4e-06 26.1 0.0 5.2e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family Rep_fac-A_C PF08646.5 KOO36030.1 - 2.9e-38 130.8 0.0 5.5e-37 126.7 0.0 2.4 2 0 0 2 2 2 1 Replication factor-A C terminal domain Rep-A_N PF04057.7 KOO36030.1 - 1e-14 54.1 0.1 2.1e-14 53.1 0.1 1.5 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.20 KOO36030.1 - 1.1e-13 50.7 0.0 9.7e-10 38.1 0.0 3.2 3 0 0 3 3 3 2 OB-fold nucleic acid binding domain PhoD PF09423.5 KOO36031.1 - 1.6e-72 244.5 0.4 2.4e-72 243.9 0.3 1.2 1 0 0 1 1 1 1 PhoD-like phosphatase Rhomboid PF01694.17 KOO36031.1 - 9.6e-21 74.3 14.2 1.9e-20 73.3 9.8 1.5 1 0 0 1 1 1 1 Rhomboid family DUF3953 PF13129.1 KOO36031.1 - 0.75 9.4 5.7 1.9 8.1 3.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3953) Tubulin PF00091.20 KOO36032.1 - 1e-42 146.4 0.0 1.5e-42 145.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Peptidase_M16 PF00675.15 KOO36033.1 - 3e-32 111.4 0.1 7e-32 110.2 0.0 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) LRR_6 PF13516.1 KOO36033.1 - 1.2e-30 102.1 29.1 0.095 12.8 0.2 19.7 20 0 0 20 20 20 6 Leucine Rich repeat Peptidase_M16_C PF05193.16 KOO36033.1 - 1.4e-24 86.7 0.0 3.2e-18 66.0 0.0 2.5 2 0 0 2 2 2 2 Peptidase M16 inactive domain SpoVS PF04232.7 KOO36033.1 - 2.8e-10 39.6 0.1 1.3e-09 37.4 0.1 2.1 1 0 0 1 1 1 1 Stage V sporulation protein S (SpoVS) LRR_4 PF12799.2 KOO36033.1 - 3.3e-05 23.3 21.9 2.4 7.8 0.1 10.4 12 0 0 12 12 12 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO36033.1 - 0.00044 19.9 22.9 20 5.6 0.1 12.4 17 0 0 17 17 17 0 Leucine Rich Repeat LRR_7 PF13504.1 KOO36033.1 - 0.0071 16.3 31.4 27 5.5 0.2 12.8 14 0 0 14 14 14 0 Leucine rich repeat CopB PF05275.6 KOO36033.1 - 0.15 11.2 0.0 0.29 10.3 0.0 1.4 1 0 0 1 1 1 0 Copper resistance protein B precursor (CopB) AA_kinase PF00696.23 KOO36035.1 - 1e-23 84.1 0.3 1.2e-23 83.9 0.2 1.0 1 0 0 1 1 1 1 Amino acid kinase family Acyl-CoA_dh_1 PF00441.19 KOO36036.1 - 1.7e-20 73.6 1.8 3.8e-19 69.2 0.5 2.9 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_C PF12806.2 KOO36036.1 - 6.3e-17 61.6 0.5 1.1e-16 60.8 0.4 1.4 1 0 0 1 1 1 1 Acetyl-CoA dehydrogenase C-terminal like Acyl-CoA_dh_M PF02770.14 KOO36036.1 - 1.9e-15 56.1 0.0 8.8e-15 53.9 0.0 2.2 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 KOO36036.1 - 0.00015 22.0 0.0 0.00034 20.8 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Aldedh PF00171.17 KOO36037.1 - 7.1e-14 50.9 5.4 0.00016 20.1 0.0 3.1 3 0 0 3 3 3 3 Aldehyde dehydrogenase family IQ PF00612.22 KOO36038.1 - 0.0036 16.8 18.3 0.012 15.1 0.9 3.3 3 0 0 3 3 3 3 IQ calmodulin-binding motif Phage_GPD PF05954.6 KOO36038.1 - 1.2 8.2 7.2 1.5 7.9 5.0 1.3 1 0 0 1 1 1 0 Phage late control gene D protein (GPD) SbmA_BacA PF05992.7 KOO36039.1 - 2.2e-63 214.3 0.8 3e-63 213.9 0.6 1.1 1 0 0 1 1 1 1 SbmA/BacA-like family Ank_2 PF12796.2 KOO36039.1 - 3.3e-25 88.2 1.3 3.9e-12 46.3 0.1 2.7 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO36039.1 - 2.3e-23 80.7 8.7 2.1e-05 24.0 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.1 KOO36039.1 - 3.7e-21 74.6 7.4 2.4e-05 24.4 0.1 4.9 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO36039.1 - 2.1e-19 69.4 1.8 2.8e-08 34.0 0.2 3.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO36039.1 - 6.3e-18 63.0 3.3 0.0025 17.8 0.0 5.3 4 0 0 4 4 4 4 Ankyrin repeat ABC_membrane_2 PF06472.10 KOO36039.1 - 8e-15 54.7 0.1 1.4e-14 53.8 0.1 1.5 1 1 0 1 1 1 1 ABC transporter transmembrane region 2 EI24 PF07264.6 KOO36039.1 - 1.2 8.5 10.9 0.039 13.3 2.2 2.1 2 0 0 2 2 2 0 Etoposide-induced protein 2.4 (EI24) Abhydrolase_3 PF07859.8 KOO36040.1 - 1.7e-19 70.2 0.0 2.7e-19 69.6 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.23 KOO36040.1 - 5.6e-12 45.1 0.1 2.5e-11 43.0 0.0 1.8 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_6 PF12697.2 KOO36040.1 - 3.7e-07 30.2 0.3 3.7e-07 30.2 0.2 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO36040.1 - 5.6e-06 26.1 0.0 1e-05 25.3 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.8 KOO36040.1 - 0.013 15.0 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Lipase PF00151.14 KOO36040.1 - 0.059 12.5 0.0 0.084 12.0 0.0 1.1 1 0 0 1 1 1 0 Lipase Peptidase_S9 PF00326.16 KOO36040.1 - 0.071 12.3 0.0 1 8.5 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family DUF3647 PF12363.3 KOO36044.1 - 0.12 12.5 2.2 3.3 7.8 0.0 3.1 2 1 0 3 3 3 0 Phage protein AAA_13 PF13166.1 KOO36044.1 - 1.6 7.1 9.0 0.58 8.5 1.2 2.2 2 1 0 2 2 2 0 AAA domain Laminin_II PF06009.7 KOO36044.1 - 3.3 7.4 12.3 7.7 6.2 0.6 3.2 3 0 0 3 3 3 0 Laminin Domain II DivIC PF04977.10 KOO36044.1 - 3.5 7.1 6.5 3.7 7.1 2.3 2.6 2 1 1 3 3 3 0 Septum formation initiator Baculo_PEP_C PF04513.7 KOO36044.1 - 8 6.2 7.3 8.5 6.1 0.3 3.2 1 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus HEAT PF02985.17 KOO36045.1 - 0.12 12.5 0.9 16 5.8 0.1 2.2 2 0 0 2 2 2 0 HEAT repeat WD40 PF00400.27 KOO36047.1 - 1.2e-22 78.9 2.6 8.6e-06 25.4 0.0 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.3 KOO36047.1 - 0.092 10.8 0.0 0.14 10.2 0.0 1.3 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Enkurin PF13864.1 KOO36048.1 - 1.2e-27 95.9 1.2 2e-27 95.2 0.8 1.3 1 0 0 1 1 1 1 Calmodulin-binding Metal_resist PF13801.1 KOO36048.1 - 0.058 13.3 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 Heavy-metal resistance CBM_48 PF02922.13 KOO36049.1 - 0.067 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Nol1_Nop2_Fmu PF01189.12 KOO36050.1 - 2.1e-17 63.4 0.0 1.6e-16 60.5 0.0 2.0 2 0 0 2 2 2 1 NOL1/NOP2/sun family EF-hand_7 PF13499.1 KOO36052.1 - 1.7e-05 24.8 0.0 4.2e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO36052.1 - 0.0013 18.4 0.0 0.0086 15.8 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 KOO36052.1 - 0.0072 15.5 0.0 0.25 10.7 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.1 KOO36052.1 - 0.11 12.0 0.0 0.46 10.1 0.0 2.0 1 1 0 1 1 1 0 EF-hand domain pair Response_reg PF00072.19 KOO36053.1 - 0.0037 17.2 0.0 0.022 14.7 0.0 2.4 1 0 0 1 1 1 1 Response regulator receiver domain PG_binding_1 PF01471.13 KOO36054.1 - 4.2e-13 49.0 0.1 4.8e-06 26.4 0.1 2.5 2 0 0 2 2 2 2 Putative peptidoglycan binding domain Glyco_hydro_25 PF01183.15 KOO36054.1 - 6.7e-06 26.0 0.0 1.1e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 ER PF01133.12 KOO36055.1 - 1e-26 92.6 0.0 1.3e-26 92.3 0.0 1.1 1 0 0 1 1 1 1 Enhancer of rudimentary UAA PF08449.6 KOO36056.1 - 0.0011 17.9 0.9 0.0029 16.5 0.6 1.7 1 1 0 1 1 1 1 UAA transporter family Gly-zipper_OmpA PF13436.1 KOO36056.1 - 0.14 11.7 1.0 0.25 11.0 0.7 1.4 1 0 0 1 1 1 0 Glycine-zipper containing OmpA-like membrane domain 2-Hacid_dh_C PF02826.14 KOO36057.1 - 1e-50 171.3 0.0 2.6e-50 170.0 0.0 1.7 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Arm PF00514.18 KOO36057.1 - 9.3e-25 85.5 22.7 8.4e-07 28.5 0.3 5.3 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat Arm_2 PF04826.8 KOO36057.1 - 3e-05 23.2 1.2 0.099 11.7 0.1 2.2 1 1 1 2 2 2 2 Armadillo-like NAD_binding_2 PF03446.10 KOO36057.1 - 0.00057 19.7 0.1 0.002 17.9 0.1 1.9 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase HEAT_2 PF13646.1 KOO36057.1 - 0.0014 18.8 8.2 0.004 17.4 2.7 2.6 1 1 1 2 2 2 2 HEAT repeats NAD_Gly3P_dh_N PF01210.18 KOO36057.1 - 0.0016 18.1 1.7 0.098 12.3 1.2 2.8 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh PF00389.25 KOO36057.1 - 0.011 15.2 0.0 0.024 14.1 0.0 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Atx10homo_assoc PF09759.4 KOO36057.1 - 0.059 13.0 3.7 14 5.4 0.8 3.7 2 1 2 4 4 4 0 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.1 KOO36057.1 - 0.065 13.7 13.8 2.9 8.4 0.2 4.2 1 1 1 3 3 3 0 HEAT-like repeat EF-hand_1 PF00036.27 KOO36058.1 - 3e-10 38.6 1.6 0.00014 20.9 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO36058.1 - 1.5e-09 36.8 1.0 0.0004 20.0 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO36058.1 - 1.6e-09 37.7 3.5 7.7e-07 29.1 0.5 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO36058.1 - 3.2e-09 36.2 2.9 0.00012 21.6 0.1 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO36058.1 - 2.9e-05 23.2 1.4 0.0048 16.1 0.2 2.5 2 0 0 2 2 2 2 EF hand p25-alpha PF05517.7 KOO36058.1 - 0.052 13.7 0.1 0.075 13.2 0.0 1.2 1 0 0 1 1 1 0 p25-alpha DUF2442 PF10387.4 KOO36058.1 - 0.061 13.3 0.5 0.88 9.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2442) SPARC_Ca_bdg PF10591.4 KOO36058.1 - 0.074 13.0 0.1 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region DnaJ PF00226.26 KOO36059.1 - 0.00023 20.8 0.0 0.00024 20.7 0.0 1.2 1 0 0 1 1 1 1 DnaJ domain Ribonuclease_P PF00825.13 KOO36060.1 - 0.057 13.3 0.8 0.076 12.9 0.5 1.3 1 0 0 1 1 1 0 Ribonuclease P Peptidase_S46 PF10459.4 KOO36060.1 - 0.11 10.8 0.4 0.12 10.7 0.3 1.0 1 0 0 1 1 1 0 Peptidase S46 Vpu PF00558.14 KOO36060.1 - 5.8 6.5 8.5 8.9 5.9 0.4 2.3 1 1 1 2 2 2 0 Vpu protein Filamin PF00630.14 KOO36061.1 - 1.2e-09 38.6 0.0 0.0016 18.9 0.0 2.5 2 0 0 2 2 2 2 Filamin/ABP280 repeat RCC1 PF00415.13 KOO36062.1 - 1e-20 73.6 23.3 6.9e-06 26.1 0.6 5.0 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO36062.1 - 2.3e-16 58.8 28.8 5.4e-05 22.6 0.7 5.5 4 1 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat Corona_S1 PF01600.11 KOO36062.1 - 0.09 11.0 5.0 0.16 10.2 0.6 2.3 2 0 0 2 2 2 0 Coronavirus S1 glycoprotein ABC_tran PF00005.22 KOO36063.1 - 6.2e-53 178.7 0.2 2.5e-25 89.3 0.1 2.4 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.2 KOO36063.1 - 8.8e-51 172.9 49.8 1.6e-33 116.2 9.6 3.1 3 0 0 3 3 3 2 ABC-2 family transporter protein Surp PF01805.15 KOO36063.1 - 1.5e-17 62.9 0.1 3e-17 62.0 0.1 1.5 1 0 0 1 1 1 1 Surp module AAA_21 PF13304.1 KOO36063.1 - 5.4e-17 62.6 4.3 4.2e-10 40.0 0.0 4.3 3 1 1 4 4 4 3 AAA domain AAA_29 PF13555.1 KOO36063.1 - 1.2e-05 24.7 4.8 0.013 14.9 0.4 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain SbcCD_C PF13558.1 KOO36063.1 - 2.2e-05 24.2 0.8 0.031 14.1 0.0 4.0 3 2 0 3 3 2 1 Putative exonuclease SbcCD, C subunit ABC2_membrane PF01061.19 KOO36063.1 - 0.00016 20.8 13.3 0.00016 20.8 9.2 3.4 2 1 1 3 3 2 1 ABC-2 type transporter ABC2_membrane_2 PF12679.2 KOO36063.1 - 0.001 18.0 32.0 0.042 12.6 8.5 2.8 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_23 PF13476.1 KOO36063.1 - 0.0014 19.0 1.6 0.68 10.2 0.0 2.7 3 0 0 3 3 2 2 AAA domain SMC_N PF02463.14 KOO36063.1 - 0.0033 16.6 0.2 0.71 9.0 0.0 3.1 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain Mg_chelatase PF01078.16 KOO36063.1 - 0.0068 15.5 0.4 0.36 9.9 0.1 2.7 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI DUF258 PF03193.11 KOO36063.1 - 0.018 14.1 0.1 2.4 7.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_33 PF13671.1 KOO36063.1 - 0.13 12.1 0.1 8.7 6.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.17 KOO36063.1 - 0.56 9.6 5.5 2.5 7.5 0.6 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_15 PF13175.1 KOO36063.1 - 0.64 9.0 0.0 2.7 6.9 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain MukB PF04310.7 KOO36063.1 - 0.84 8.9 3.4 9 5.5 0.2 2.4 2 0 0 2 2 2 0 MukB N-terminal DUF3584 PF12128.3 KOO36063.1 - 7.3 3.7 3.8 7.9 3.6 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) FAD_binding_3 PF01494.14 KOO36065.1 - 1.8e-15 56.8 5.7 3.2e-06 26.4 1.0 3.2 3 0 0 3 3 3 3 FAD binding domain NAD_binding_8 PF13450.1 KOO36065.1 - 1.6e-06 28.0 0.3 6.8e-06 26.0 0.2 2.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOO36065.1 - 0.0002 20.3 1.3 0.0002 20.3 0.9 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 KOO36065.1 - 0.00021 20.3 0.5 0.00021 20.3 0.4 2.0 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.9 KOO36065.1 - 0.00099 19.0 0.5 0.01 15.7 0.2 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOO36065.1 - 0.046 13.7 0.3 0.13 12.2 0.3 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 KOO36065.1 - 0.12 10.9 0.4 1.3 7.5 0.1 2.0 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox PF00070.22 KOO36065.1 - 0.14 12.5 0.4 0.49 10.8 0.1 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 KOO36065.1 - 0.15 10.5 0.2 0.21 10.0 0.2 1.1 1 0 0 1 1 1 0 HI0933-like protein Nucleotid_trans PF03407.11 KOO36066.1 - 3.6e-33 115.1 0.0 5e-33 114.6 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase DUF4127 PF13552.1 KOO36066.1 - 0.21 9.9 0.0 0.32 9.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4127) LRR_5 PF13306.1 KOO36067.1 - 2.8e-74 246.9 0.0 7.8e-40 135.5 0.0 2.2 1 1 1 2 2 2 2 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO36067.1 - 8.1e-24 83.1 0.0 1.4e-06 27.8 0.1 5.7 3 1 3 6 6 6 4 Leucine rich repeat Skp1 PF01466.14 KOO36067.1 - 0.0096 15.9 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 1 Skp1 family, dimerisation domain He_PIG PF05345.7 KOO36067.1 - 0.46 10.5 6.4 33 4.6 0.0 5.8 7 0 0 7 7 7 0 Putative Ig domain EB1 PF03271.12 KOO36068.1 - 1.5e-13 50.5 1.3 3.4e-13 49.3 0.9 1.7 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.26 KOO36068.1 - 2.5e-07 30.6 0.0 8.1e-07 29.0 0.0 1.9 1 0 0 1 1 1 1 Calponin homology (CH) domain SR-25 PF10500.4 KOO36068.1 - 0.56 9.6 21.5 1.1 8.7 14.9 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF2475 PF10629.4 KOO36069.1 - 0.00019 21.6 0.6 0.00055 20.1 0.2 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF2475) DUF4540 PF15073.1 KOO36069.1 - 0.095 13.2 0.7 0.28 11.7 0.1 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4540) CTDII PF01556.13 KOO36070.1 - 3.6e-23 81.2 0.1 1.4e-22 79.3 0.0 2.0 2 0 0 2 2 2 1 DnaJ C terminal domain tRNA_int_endo PF01974.12 KOO36071.1 - 0.012 15.3 0.0 3.4 7.5 0.0 2.1 1 1 1 2 2 2 0 tRNA intron endonuclease, catalytic C-terminal domain Pr_beta_C PF12465.3 KOO36073.1 - 0.065 12.5 0.1 0.12 11.6 0.0 1.5 1 0 0 1 1 1 0 Proteasome beta subunits C terminal DUF948 PF06103.6 KOO36074.1 - 0.41 10.5 6.5 0.21 11.4 0.1 3.6 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Attachment_P66 PF11263.3 KOO36075.1 - 0.054 12.5 0.2 0.081 11.9 0.2 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi attachment protein P66 ERG4_ERG24 PF01222.12 KOO36076.1 - 1.6e-64 218.0 10.6 2.1e-64 217.6 7.4 1.2 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 KOO36076.1 - 4.7e-06 26.0 2.0 7.3e-06 25.4 0.2 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) DUF2114 PF09887.4 KOO36078.1 - 0.27 9.5 0.0 2.8 6.1 0.0 2.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2114) LRR_6 PF13516.1 KOO36079.1 - 4.3e-12 44.7 0.5 0.05 13.6 0.0 5.8 6 0 0 6 6 6 3 Leucine Rich repeat LRR_4 PF12799.2 KOO36079.1 - 2.6e-05 23.7 0.0 0.59 9.8 0.0 3.6 3 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO36079.1 - 0.0024 17.5 1.1 2.2 8.0 0.1 3.5 2 2 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 KOO36079.1 - 0.0086 15.9 0.0 88 3.7 0.0 4.4 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_7 PF13504.1 KOO36079.1 - 0.0095 15.9 2.7 14 6.4 0.0 4.7 5 0 0 5 5 5 1 Leucine rich repeat AAA_12 PF13087.1 KOO36080.1 - 1.5e-49 168.1 0.0 3.5e-49 166.9 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 KOO36080.1 - 9.4e-41 139.9 0.1 2.8e-38 131.8 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOO36080.1 - 1.2e-11 44.1 2.7 7.1e-11 41.7 0.9 2.7 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 KOO36080.1 - 3.1e-10 39.9 2.2 1.6e-09 37.6 0.2 2.5 2 1 0 2 2 1 1 AAA domain Viral_helicase1 PF01443.13 KOO36080.1 - 6.4e-07 29.1 0.0 0.012 15.1 0.0 3.1 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.1 KOO36080.1 - 0.00041 20.3 0.1 0.0009 19.2 0.1 1.6 1 0 0 1 1 1 1 AAA ATPase domain PhoH PF02562.11 KOO36080.1 - 0.00062 19.0 0.0 0.55 9.4 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein DUF2075 PF09848.4 KOO36080.1 - 0.00079 18.4 0.0 0.011 14.7 0.0 2.2 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.1 KOO36080.1 - 0.0011 18.4 0.1 0.0044 16.4 0.1 1.8 1 1 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.1 KOO36080.1 - 0.0059 16.7 0.1 0.06 13.4 0.0 2.2 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_22 PF13401.1 KOO36080.1 - 0.047 13.8 0.0 0.11 12.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 KOO36080.1 - 0.078 12.0 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin ResIII PF04851.10 KOO36080.1 - 0.079 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_5 PF07728.9 KOO36080.1 - 0.099 12.3 0.1 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.24 KOO36080.1 - 0.1 12.8 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 KOO36080.1 - 0.16 11.6 0.1 0.39 10.3 0.1 1.7 1 0 0 1 1 1 0 NACHT domain UvrD-helicase PF00580.16 KOO36080.1 - 0.24 10.6 0.0 2.1 7.5 0.0 1.9 1 1 1 2 2 2 0 UvrD/REP helicase N-terminal domain PspA_IM30 PF04012.7 KOO36081.1 - 0.033 13.5 5.5 0.036 13.4 3.8 1.1 1 0 0 1 1 1 0 PspA/IM30 family DUF4268 PF14088.1 KOO36081.1 - 0.079 12.6 0.6 0.1 12.2 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4268) DUF3166 PF11365.3 KOO36081.1 - 0.12 12.8 2.0 0.14 12.5 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3166) Acyl-CoA_dh_2 PF08028.6 KOO36081.1 - 0.37 11.0 2.5 0.39 10.9 1.8 1.1 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain HlyD PF00529.15 KOO36081.1 - 4.2 6.5 6.9 4.7 6.4 4.8 1.0 1 0 0 1 1 1 0 HlyD family secretion protein Ribosomal_60s PF00428.14 KOO36081.1 - 8.3 6.8 12.0 22 5.5 8.3 1.6 1 1 0 1 1 1 0 60s Acidic ribosomal protein Usp PF00582.21 KOO36082.1 - 2.2e-11 44.1 3.3 4.2e-07 30.2 0.1 3.3 2 2 0 2 2 2 2 Universal stress protein family Arm PF00514.18 KOO36084.1 - 1.3e-11 43.8 1.6 3.1e-08 33.1 0.0 2.6 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat ART PF01129.13 KOO36085.1 - 7e-07 28.5 0.9 1.4e-06 27.5 0.0 1.8 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.9 KOO36085.1 - 2.3e-06 26.9 0.0 5.3e-06 25.7 0.0 1.7 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme Apolipoprotein PF01442.13 KOO36085.1 - 0.66 9.4 0.0 0.66 9.4 0.0 3.5 3 1 0 3 3 3 0 Apolipoprotein A1/A4/E domain Mnd1 PF03962.10 KOO36085.1 - 0.92 9.1 7.3 0.3 10.7 2.6 1.9 2 0 0 2 2 2 0 Mnd1 family Cytochrome-c551 PF10643.4 KOO36085.1 - 4.6 6.4 4.6 0.79 8.9 0.2 1.8 2 0 0 2 2 2 0 Photosystem P840 reaction-centre cytochrome c-551 Striatin PF08232.7 KOO36085.1 - 7 6.9 8.1 0.58 10.4 0.8 2.6 3 0 0 3 3 3 0 Striatin family EF-hand_5 PF13202.1 KOO36088.1 - 8.7e-06 24.8 0.0 1.6e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KOO36088.1 - 6e-05 22.0 0.0 0.00011 21.1 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 KOO36088.1 - 0.0005 19.6 0.0 0.0013 18.3 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.1 KOO36088.1 - 0.0066 16.5 0.0 0.0094 16.0 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO36088.1 - 0.0072 16.1 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO36088.1 - 0.23 11.4 2.5 0.61 10.1 0.0 2.5 1 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region NAM-associated PF14303.1 KOO36088.1 - 0.98 9.7 18.2 1.1 9.5 12.6 1.1 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain CMV_1a PF12467.3 KOO36088.1 - 4 7.7 15.6 5.4 7.3 10.8 1.1 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family Effector_1 PF04518.7 KOO36088.1 - 5 6.0 13.0 5.5 5.8 9.0 1.0 1 0 0 1 1 1 0 Effector from type III secretion system Gly-zipper_Omp PF13488.1 KOO36089.1 - 6.9 6.3 17.5 0.59 9.8 1.8 3.5 3 0 0 3 3 3 0 Glycine zipper DUF1269 PF06897.7 KOO36089.1 - 8.9 6.4 13.8 0.85 9.6 0.6 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1269) 2OG-FeII_Oxy_3 PF13640.1 KOO36090.1 - 5.1e-10 39.7 0.0 6.7e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO36090.1 - 0.00045 19.7 0.0 0.00076 19.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DivIVA PF05103.8 KOO36091.1 - 0.71 9.9 15.4 2 8.4 3.2 2.1 1 1 1 2 2 2 0 DivIVA protein ATP-synt_B PF00430.13 KOO36091.1 - 2.2 8.0 21.6 0.88 9.3 11.3 2.3 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) Rab3-GTPase_cat PF13890.1 KOO36092.1 - 7.3e-36 123.0 0.0 2e-35 121.6 0.0 1.7 1 0 0 1 1 1 1 Rab3 GTPase-activating protein catalytic subunit Pkinase PF00069.20 KOO36092.1 - 1.7e-30 106.0 0.0 2.8e-30 105.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO36092.1 - 3.6e-15 55.7 0.0 6e-15 55.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO36092.1 - 0.0098 15.6 1.2 0.0098 15.6 0.8 3.6 3 2 0 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.9 KOO36092.1 - 0.046 12.7 0.9 0.077 12.0 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF570 PF04489.8 KOO36097.1 - 0.1 11.0 0.1 0.2 10.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF570) LRR_6 PF13516.1 KOO36099.1 - 2.7e-48 156.5 13.0 0.0018 18.1 0.0 13.1 13 0 0 13 13 13 10 Leucine Rich repeat LRR_1 PF00560.28 KOO36099.1 - 4e-07 29.1 0.0 1.3e+02 3.2 0.0 9.6 10 1 0 10 10 10 0 Leucine Rich Repeat LRR_8 PF13855.1 KOO36099.1 - 4.9e-05 22.9 3.3 6.9 6.5 0.0 6.4 5 2 1 6 6 6 1 Leucine rich repeat LRR_4 PF12799.2 KOO36099.1 - 0.0017 17.9 16.2 10 5.8 0.2 8.1 6 3 4 10 10 10 3 Leucine Rich repeats (2 copies) Skp1 PF01466.14 KOO36099.1 - 0.03 14.3 0.0 0.11 12.5 0.0 1.9 1 0 0 1 1 1 0 Skp1 family, dimerisation domain EIF_2_alpha PF07541.7 KOO36099.1 - 0.039 13.6 2.5 9.6 5.9 0.0 3.6 3 1 0 3 3 3 0 Eukaryotic translation initiation factor 2 alpha subunit LRR_7 PF13504.1 KOO36099.1 - 0.16 12.2 14.8 3.5e+02 2.1 0.0 10.0 13 0 0 13 13 13 0 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO36099.1 - 1.9 8.6 9.2 8.9 6.5 0.0 5.2 5 2 0 5 5 5 0 RNA 2'-O ribose methyltransferase substrate binding DUF2202 PF09968.4 KOO36099.1 - 3.1 7.4 7.1 1.1e+02 2.4 0.1 5.0 2 2 5 7 7 7 0 Uncharacterized protein domain (DUF2202) DUF221 PF02714.10 KOO36100.1 - 5.5e-14 51.7 8.6 7.5e-07 28.3 0.1 2.9 3 0 0 3 3 3 2 Domain of unknown function DUF221 IncA PF04156.9 KOO36120.1 - 0.0018 17.9 14.6 0.0018 17.9 10.1 1.5 1 1 0 1 1 1 1 IncA protein DUF948 PF06103.6 KOO36120.1 - 0.037 13.8 2.7 0.14 12.0 0.3 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) ATP-synt_D PF01813.12 KOO36120.1 - 0.045 13.2 4.4 0.058 12.9 2.5 1.7 1 1 1 2 2 2 0 ATP synthase subunit D DUF3584 PF12128.3 KOO36120.1 - 0.05 10.9 18.0 0.06 10.6 12.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Filament PF00038.16 KOO36120.1 - 0.05 13.0 15.4 0.17 11.3 10.6 1.7 1 1 0 1 1 1 0 Intermediate filament protein FliD_N PF02465.13 KOO36120.1 - 0.053 13.8 0.6 0.053 13.8 0.4 1.9 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Laminin_II PF06009.7 KOO36120.1 - 0.077 12.7 6.7 0.24 11.1 0.8 2.6 1 1 2 3 3 3 0 Laminin Domain II SPAM PF02090.10 KOO36120.1 - 0.08 12.9 4.0 0.14 12.1 0.9 2.2 2 0 0 2 2 2 0 Salmonella surface presentation of antigen gene type M protein DUF2959 PF11172.3 KOO36120.1 - 0.1 12.3 6.9 0.087 12.5 3.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2959) Med11 PF10280.4 KOO36120.1 - 0.11 12.6 4.7 0.076 13.0 1.8 1.8 1 1 0 1 1 1 0 Mediator complex protein CENP-H PF05837.7 KOO36120.1 - 0.23 11.6 11.6 0.18 11.9 1.3 2.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Effector_1 PF04518.7 KOO36120.1 - 0.46 9.4 10.0 0.18 10.7 1.7 2.0 2 0 0 2 2 2 0 Effector from type III secretion system CASP_C PF08172.7 KOO36120.1 - 0.56 9.1 9.6 0.11 11.5 2.5 2.2 2 0 0 2 2 2 0 CASP C terminal Prominin PF05478.6 KOO36120.1 - 0.58 7.6 8.3 1.3 6.4 5.6 1.5 1 1 0 1 1 1 0 Prominin Bacillus_HBL PF05791.6 KOO36120.1 - 0.71 9.2 7.7 0.23 10.8 2.0 2.0 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Matrilin_ccoil PF10393.4 KOO36120.1 - 0.84 9.0 4.9 0.23 10.8 0.7 2.1 3 0 0 3 3 1 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF972 PF06156.8 KOO36120.1 - 0.92 9.8 12.5 1.8 8.9 1.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF972) NPV_P10 PF05531.7 KOO36120.1 - 1.1 9.6 10.7 11 6.3 1.6 3.4 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein ING PF12998.2 KOO36120.1 - 1.3 9.3 9.7 0.29 11.4 3.3 2.1 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding FlxA PF14282.1 KOO36120.1 - 1.7 8.6 11.8 3.8 7.4 3.8 2.4 1 1 0 2 2 2 0 FlxA-like protein UPF0242 PF06785.6 KOO36120.1 - 2.7 6.5 10.2 3.4 6.2 7.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) DUF3391 PF11871.3 KOO36120.1 - 2.9 8.1 9.2 1.5 9.0 0.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3391) DUF2951 PF11166.3 KOO36120.1 - 3.7 7.4 7.6 1.9 8.3 2.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) UPF0184 PF03670.8 KOO36120.1 - 4 7.6 7.3 0.22 11.7 0.7 2.2 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0184) PilO PF04350.8 KOO36120.1 - 5 7.0 8.6 7.3 6.4 0.0 3.1 1 1 2 3 3 3 0 Pilus assembly protein, PilO Rsa3 PF14615.1 KOO36120.1 - 5.8 6.2 7.5 0.41 9.9 0.6 2.4 3 0 0 3 3 3 0 Ribosome-assembly protein 3 SPX PF03105.14 KOO36120.1 - 5.9 6.5 7.3 7.2 6.3 5.1 1.2 1 0 0 1 1 1 0 SPX domain GAS PF13851.1 KOO36120.1 - 6.1 5.9 16.4 3.7 6.6 2.0 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Tho2 PF11262.3 KOO36120.1 - 6.2 5.7 7.4 1.1 8.2 1.5 1.9 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 Syntaxin-6_N PF09177.6 KOO36120.1 - 7.5 7.0 10.0 6.9 7.1 1.7 2.9 1 1 2 3 3 3 0 Syntaxin 6, N-terminal TPR_MLP1_2 PF07926.7 KOO36120.1 - 9 6.0 18.6 0.95 9.2 4.8 2.7 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4239 PF14023.1 KOO36120.1 - 9.5 5.5 6.3 2.4 7.4 0.7 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF4239) TBPIP PF07106.8 KOO36120.1 - 10 5.6 10.4 2.2 7.7 1.8 2.3 1 1 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Syntaxin-6_N PF09177.6 KOO36121.1 - 0.007 16.7 2.6 0.013 15.8 1.7 1.5 1 1 0 1 1 1 1 Syntaxin 6, N-terminal Filament PF00038.16 KOO36121.1 - 0.013 15.0 2.1 0.014 14.8 1.4 1.1 1 0 0 1 1 1 0 Intermediate filament protein TMCO5 PF14992.1 KOO36121.1 - 0.035 13.2 2.0 0.044 12.9 1.4 1.1 1 0 0 1 1 1 0 TMCO5 family Rab5-bind PF09311.6 KOO36121.1 - 0.036 13.9 4.6 0.067 13.0 3.2 1.5 1 1 0 1 1 1 0 Rabaptin-like protein 7TMR-HDED PF07697.6 KOO36121.1 - 0.037 13.7 3.7 0.069 12.8 2.5 1.4 1 1 0 1 1 1 0 7TM-HD extracellular Las1 PF04031.8 KOO36121.1 - 0.061 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Las1-like DUF3106 PF11304.3 KOO36121.1 - 0.17 12.2 2.3 0.71 10.3 1.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3106) Myb_DNA-binding PF00249.26 KOO36123.1 - 1.7e-23 82.3 6.1 6.2e-11 42.1 2.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 KOO36123.1 - 2.4e-20 72.4 0.2 3.2e-12 46.3 0.3 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.1 KOO36123.1 - 0.2 11.7 3.9 9.4 6.4 1.2 2.5 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain Pkinase PF00069.20 KOO36124.1 - 9.9e-57 192.0 0.0 1.2e-56 191.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO36124.1 - 1.4e-38 132.4 0.0 1.8e-38 132.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO36124.1 - 4.2e-09 35.7 0.0 1.9e-08 33.6 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 KOO36124.1 - 0.15 11.1 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 KOO36124.1 - 0.17 11.5 1.7 2.8 7.6 0.0 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family Ank_2 PF12796.2 KOO36125.1 - 2.1e-18 66.4 3.6 6.7e-09 35.9 0.1 2.6 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO36125.1 - 5.5e-14 52.2 7.1 2.5e-05 24.6 0.5 4.1 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO36125.1 - 1.4e-13 49.6 11.1 0.00058 19.8 0.1 5.0 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.25 KOO36125.1 - 1.1e-12 47.0 14.1 5.6e-05 22.7 0.0 5.4 6 0 0 6 6 6 3 Ankyrin repeat EF-hand_1 PF00036.27 KOO36125.1 - 1e-10 40.0 0.2 0.00019 20.4 0.1 2.5 2 0 0 2 2 2 2 EF hand Ank_5 PF13857.1 KOO36125.1 - 4.9e-10 39.3 11.4 3.4e-06 27.1 0.2 3.9 3 1 1 4 4 4 3 Ankyrin repeats (many copies) EF-hand_7 PF13499.1 KOO36125.1 - 7.5e-10 38.8 0.1 1.5e-09 37.8 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO36125.1 - 4.4e-08 32.3 0.0 0.0031 17.2 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO36125.1 - 0.00011 21.3 2.4 0.085 12.2 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO36125.1 - 0.0012 18.3 0.1 0.0029 17.1 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_9 PF14658.1 KOO36125.1 - 0.0031 17.4 0.0 0.0059 16.4 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain Thioredoxin PF00085.15 KOO36126.1 - 2.5e-24 84.9 0.0 4.7e-24 84.0 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 KOO36126.1 - 4.2e-05 23.6 0.0 0.00025 21.2 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.16 KOO36126.1 - 0.00026 20.6 0.0 0.0012 18.4 0.0 1.9 2 0 0 2 2 2 1 AhpC/TSA family Thioredoxin_8 PF13905.1 KOO36126.1 - 0.00082 19.4 0.0 0.0021 18.1 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_7 PF13899.1 KOO36126.1 - 0.024 14.6 0.0 0.043 13.8 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like T4_deiodinase PF00837.12 KOO36126.1 - 0.12 11.3 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Iodothyronine deiodinase cNMP_binding PF00027.24 KOO36127.1 - 3.8e-11 42.6 0.0 1.8e-05 24.4 0.0 2.8 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain Galactosyl_T PF01762.16 KOO36128.1 - 9.1e-08 31.9 0.0 1.8e-07 30.9 0.0 1.4 2 0 0 2 2 2 1 Galactosyltransferase PapD-like PF14874.1 KOO36129.1 - 0.00082 19.2 0.0 0.032 14.1 0.0 2.3 2 0 0 2 2 2 1 Flagellar-associated PapD-like DGF-1_C PF11040.3 KOO36129.1 - 0.19 11.6 6.0 0.069 13.0 1.7 2.2 2 0 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF501 PF04417.7 KOO36134.1 - 0.012 15.4 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF501) Herpes_capsid PF06112.6 KOO36134.1 - 0.087 12.8 2.2 0.2 11.6 1.5 1.6 1 1 0 1 1 1 0 Gammaherpesvirus capsid protein DUF4570 PF15134.1 KOO36134.1 - 0.092 12.5 1.9 0.15 11.8 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) DUF3866 PF12982.2 KOO36134.1 - 0.15 10.9 0.2 0.22 10.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3866) MMR_HSR1 PF01926.18 KOO36135.1 - 0.00047 20.1 0.1 0.00078 19.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GBP PF02263.14 KOO36135.1 - 0.00051 19.1 3.1 0.0083 15.2 0.0 2.1 1 1 1 2 2 2 2 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.18 KOO36135.1 - 0.031 14.0 0.6 0.43 10.3 0.0 2.2 1 1 1 2 2 2 0 Dynamin family DUF2656 PF10847.3 KOO36135.1 - 0.044 13.7 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2656) Arf PF00025.16 KOO36135.1 - 0.13 11.4 0.3 0.24 10.6 0.0 1.5 2 0 0 2 2 2 0 ADP-ribosylation factor family Helicase_C PF00271.26 KOO36139.1 - 1.9e-09 37.2 0.0 3e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4117 PF13491.1 KOO36140.1 - 0.057 12.8 4.0 0.074 12.5 2.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4117) Fig1 PF12351.3 KOO36140.1 - 0.1 12.4 3.6 0.13 12.1 2.5 1.2 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 Nramp PF01566.13 KOO36140.1 - 1.3 7.7 7.3 0.83 8.3 3.7 1.6 1 1 0 2 2 2 0 Natural resistance-associated macrophage protein TTL PF03133.10 KOO36141.1 - 1.6e-32 112.6 0.0 2.2e-32 112.1 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 KOO36141.1 - 0.046 12.5 0.0 0.87 8.3 0.0 2.1 2 0 0 2 2 2 0 YheC/D like ATP-grasp Dala_Dala_lig_C PF07478.8 KOO36141.1 - 0.08 12.3 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus NAD_binding_1 PF00175.16 KOO36143.1 - 4.4e-20 72.2 0.0 8.2e-20 71.4 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 KOO36143.1 - 1.2e-14 54.1 0.0 1.6e-13 50.6 0.0 2.1 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain Pkinase_Tyr PF07714.12 KOO36143.1 - 0.026 13.6 0.0 0.041 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase NAD_binding_6 PF08030.7 KOO36143.1 - 0.035 13.9 0.0 0.27 11.1 0.0 2.0 2 0 0 2 2 2 0 Ferric reductase NAD binding domain Exonuc_VII_L PF02601.10 KOO36144.1 - 0.3 10.2 15.0 0.37 9.9 10.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit ALMT PF11744.3 KOO36144.1 - 3.4 6.2 6.8 4 5.9 4.7 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter V_ATPase_I PF01496.14 KOO36144.1 - 4.5 5.0 9.7 5.6 4.6 6.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EF-hand_6 PF13405.1 KOO36145.1 - 1.4e-09 37.0 0.0 3.1e-05 23.4 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO36145.1 - 2e-09 37.4 0.0 5.3e-09 36.0 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO36145.1 - 1.9e-07 29.9 0.0 0.0016 17.5 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO36145.1 - 0.00017 20.7 0.0 0.02 14.2 0.0 2.6 2 0 0 2 2 2 1 EF hand DUF2407 PF10302.4 KOO36145.1 - 0.00086 19.4 0.0 0.004 17.3 0.0 2.1 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain EF-hand_8 PF13833.1 KOO36145.1 - 0.0022 17.5 0.0 0.0053 16.3 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair ubiquitin PF00240.18 KOO36145.1 - 0.06 12.7 0.0 0.25 10.7 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin family NRPS PF08415.5 KOO36147.1 - 0.035 13.8 0.2 2.1 8.1 0.0 2.2 2 0 0 2 2 2 0 Nonribosomal peptide synthase DUF1042 PF06294.6 KOO36148.1 - 6.2e-27 94.1 0.0 9.9e-27 93.4 0.0 1.3 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1042) CAMSAP_CH PF11971.3 KOO36148.1 - 3e-10 39.5 0.0 8.2e-10 38.2 0.0 1.8 1 0 0 1 1 1 1 CAMSAP CH domain CH PF00307.26 KOO36148.1 - 0.019 15.0 0.0 0.055 13.5 0.0 1.8 1 0 0 1 1 1 0 Calponin homology (CH) domain DHQ_synthase PF01761.15 KOO36149.1 - 5.8e-93 310.5 0.0 7.6e-93 310.2 0.0 1.1 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.1 KOO36149.1 - 5.8e-09 35.6 2.0 4.4e-06 26.1 0.1 3.1 2 1 0 3 3 3 2 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.14 KOO36149.1 - 0.00038 19.2 1.7 0.096 11.3 0.3 2.5 3 0 0 3 3 3 2 Iron-containing alcohol dehydrogenase DUF393 PF04134.7 KOO36150.1 - 0.0027 18.7 4.0 0.41 11.7 0.9 2.1 1 1 1 2 2 2 2 Protein of unknown function, DUF393 zf-DHHC PF01529.15 KOO36151.1 - 5.5e-19 68.2 0.0 9.6e-19 67.4 0.0 1.4 1 1 0 1 1 1 1 DHHC palmitoyltransferase EF-hand_7 PF13499.1 KOO36152.1 - 4.5e-07 29.9 0.3 0.0041 17.2 0.0 3.1 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO36152.1 - 0.021 14.6 0.2 0.29 11.1 0.0 2.9 3 0 0 3 3 3 0 EF-hand domain Glyco_transf_41 PF13844.1 KOO36152.1 - 0.18 9.7 0.0 0.27 9.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 41 EF-hand_1 PF00036.27 KOO36152.1 - 0.24 10.8 0.8 0.71 9.3 0.1 2.2 2 0 0 2 2 2 0 EF hand EF-hand_5 PF13202.1 KOO36152.1 - 1.3 8.4 4.7 0.63 9.4 0.1 2.6 3 0 0 3 3 3 0 EF hand ART PF01129.13 KOO36153.1 - 8.5e-07 28.3 0.1 2.8e-05 23.3 0.0 2.5 1 1 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.9 KOO36153.1 - 9.8e-06 24.9 0.3 0.00034 19.8 0.2 2.4 1 1 0 1 1 1 1 ADP-ribosyltransferase exoenzyme DUF1049 PF06305.6 KOO36153.1 - 4.4 6.8 5.3 4.9 6.7 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) Rho_Binding PF08912.6 KOO36153.1 - 9.6 6.5 15.4 11 6.3 1.0 2.8 2 0 0 2 2 2 0 Rho Binding Pkinase PF00069.20 KOO36454.1 - 9.2e-30 103.6 0.0 1.4e-29 103.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO36454.1 - 1.8e-23 82.9 0.0 2.7e-23 82.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_4 PF12763.2 KOO36454.1 - 0.00037 20.1 0.0 0.00063 19.4 0.0 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand APH PF01636.18 KOO36454.1 - 0.00095 18.9 0.1 0.02 14.5 0.1 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.6 KOO36454.1 - 0.086 11.6 0.0 0.15 10.8 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase EF-hand_7 PF13499.1 KOO36454.1 - 0.11 12.6 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair Kinase-like PF14531.1 KOO36454.1 - 0.15 11.0 0.0 0.24 10.3 0.0 1.2 1 0 0 1 1 1 0 Kinase-like VWA_3 PF13768.1 KOO36457.1 - 0.044 13.4 0.0 0.14 11.8 0.0 1.8 2 0 0 2 2 2 0 von Willebrand factor type A domain Chromo PF00385.19 KOO36458.1 - 6.5e-10 38.5 0.0 1.5e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain SET PF00856.23 KOO36458.1 - 4.1e-06 27.2 0.0 0.0034 17.6 0.0 3.2 3 0 0 3 3 3 2 SET domain Agenet PF05641.7 KOO36458.1 - 0.00019 21.5 0.2 0.076 13.1 0.0 3.3 4 0 0 4 4 4 1 Agenet domain PHD PF00628.24 KOO36458.1 - 0.00035 20.1 6.0 0.00066 19.3 4.2 1.5 1 0 0 1 1 1 1 PHD-finger Tcp10_C PF07202.8 KOO36458.1 - 0.21 11.1 0.0 2.5 7.5 0.0 2.1 2 0 0 2 2 2 0 T-complex protein 10 C-terminus PHD_2 PF13831.1 KOO36458.1 - 0.59 9.5 3.1 1.2 8.5 2.1 1.5 1 0 0 1 1 1 0 PHD-finger C1_1 PF00130.17 KOO36458.1 - 3.1 7.6 5.1 1.9 8.2 1.7 2.0 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Ank_2 PF12796.2 KOO36459.1 - 1.2e-32 112.0 3.5 7.6e-18 64.6 0.2 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO36459.1 - 1.7e-26 90.6 3.9 6.3e-08 32.0 0.1 4.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.1 KOO36459.1 - 7.9e-22 77.2 3.9 1.4e-07 31.8 0.0 4.7 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO36459.1 - 2.5e-21 75.1 3.5 2.3e-09 37.1 0.2 4.1 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO36459.1 - 1.4e-19 68.2 2.0 2.9e-06 26.9 0.1 5.4 6 0 0 6 6 6 3 Ankyrin repeat zf-MIZ PF02891.15 KOO36460.1 - 0.04 13.4 0.5 6.6 6.3 0.0 2.3 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger YccV-like PF08755.6 KOO36461.1 - 3.6e-10 39.6 0.0 0.00056 19.7 0.0 3.7 3 1 0 3 3 3 2 Hemimethylated DNA-binding protein YccV like Dor1 PF04124.7 KOO36461.1 - 0.038 12.4 0.1 0.061 11.7 0.1 1.3 1 0 0 1 1 1 0 Dor1-like family UVR PF02151.14 KOO36461.1 - 0.53 9.8 7.8 0.055 13.0 1.9 2.0 2 0 0 2 2 2 0 UvrB/uvrC motif SMC_N PF02463.14 KOO36462.1 - 3.2e-16 59.2 36.7 1.6e-15 56.9 25.4 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 KOO36462.1 - 5e-07 30.2 34.4 5e-07 30.2 23.9 5.2 2 2 1 3 3 3 1 AAA domain AAA_21 PF13304.1 KOO36462.1 - 3.4e-05 23.9 1.3 0.0064 16.4 0.7 2.9 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.1 KOO36462.1 - 5.8e-05 22.5 0.0 0.00015 21.2 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain Sec8_exocyst PF04048.9 KOO36462.1 - 0.019 14.6 0.6 0.019 14.6 0.4 6.0 4 2 2 6 6 6 0 Sec8 exocyst complex component specific domain AAA_15 PF13175.1 KOO36462.1 - 0.024 13.6 22.3 0.062 12.3 9.6 3.9 3 1 0 3 3 3 0 AAA ATPase domain MMR_HSR1 PF01926.18 KOO36462.1 - 0.074 13.0 0.3 0.45 10.4 0.2 2.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.22 KOO36462.1 - 0.12 12.6 0.1 0.12 12.6 0.0 5.7 4 2 0 4 4 4 0 ABC transporter Ribosomal_60s PF00428.14 KOO36465.1 - 3.9 7.9 21.8 13 6.2 15.1 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein SCP2 PF02036.12 KOO36467.1 - 2e-21 76.1 0.3 2.4e-21 75.9 0.2 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.1 KOO36467.1 - 9.5e-06 25.6 0.2 1.2e-05 25.2 0.1 1.3 1 1 0 1 1 1 1 Alkyl sulfatase C-terminal Na_H_Exchanger PF00999.16 KOO36468.1 - 1.8e-31 109.0 35.6 5.7e-23 81.0 14.1 2.1 1 1 1 2 2 2 2 Sodium/hydrogen exchanger family TTL PF03133.10 KOO36469.1 - 7.9e-52 176.0 0.0 1.2e-51 175.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family UQ_con PF00179.21 KOO36469.1 - 2.5e-24 85.2 0.0 3.7e-24 84.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme ATPgrasp_YheCD PF14398.1 KOO36469.1 - 0.0011 17.8 0.0 0.013 14.3 0.0 2.3 2 1 0 2 2 2 1 YheC/D like ATP-grasp Prok-E2_B PF14461.1 KOO36469.1 - 0.0022 17.7 0.0 0.0063 16.2 0.0 1.7 2 0 0 2 2 2 1 Prokaryotic E2 family B ATP-grasp_4 PF13535.1 KOO36469.1 - 0.074 12.7 0.0 0.21 11.2 0.0 1.7 2 0 0 2 2 2 0 ATP-grasp domain ATP-grasp_3 PF02655.9 KOO36469.1 - 0.16 11.7 0.0 0.35 10.7 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain RimK PF08443.6 KOO36469.1 - 0.2 11.1 0.0 3.4 7.1 0.0 2.1 2 0 0 2 2 2 0 RimK-like ATP-grasp domain RWD PF05773.17 KOO36469.1 - 0.22 11.4 0.0 0.35 10.7 0.0 1.3 1 0 0 1 1 1 0 RWD domain PDZ PF00595.19 KOO36552.1 - 1.7e-17 63.3 0.1 0.0048 17.0 0.0 4.7 4 1 0 4 4 4 4 PDZ domain (Also known as DHR or GLGF) DUF3394 PF11874.3 KOO36552.1 - 0.00074 19.1 0.0 4.4 6.8 0.0 3.4 3 0 0 3 3 3 2 Domain of unknown function (DUF3394) WW PF00397.21 KOO36552.1 - 0.0054 16.5 0.2 0.011 15.5 0.2 1.6 1 0 0 1 1 1 1 WW domain Glycos_transf_1 PF00534.15 KOO36552.1 - 0.027 13.8 0.1 8.2 5.8 0.0 2.5 2 0 0 2 2 2 0 Glycosyl transferases group 1 TilS PF09179.6 KOO36552.1 - 0.049 13.6 0.4 0.13 12.2 0.3 1.8 1 0 0 1 1 1 0 TilS substrate binding domain TPX2_importin PF12214.3 KOO36612.1 - 1.1e-11 45.1 15.6 6.5e-10 39.3 1.2 5.7 3 1 2 6 6 6 3 Cell cycle regulated microtubule associated protein TPX2 PF06886.6 KOO36612.1 - 2.3e-07 30.7 11.6 2.3e-07 30.7 8.1 4.9 6 0 0 6 6 6 2 Targeting protein for Xklp2 (TPX2) RPE65 PF03055.10 KOO36613.1 - 1e-57 195.7 0.0 6.7e-37 127.1 0.0 2.2 1 1 1 2 2 2 2 Retinal pigment epithelial membrane protein Cyt-b5 PF00173.23 KOO36613.1 - 2.4e-21 75.3 0.0 4.2e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Lipase_GDSL_2 PF13472.1 KOO36617.1 - 1.1e-09 38.6 0.0 1.5e-09 38.2 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 KOO36617.1 - 0.058 13.2 0.0 0.084 12.6 0.0 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase Methyltransf_32 PF13679.1 KOO36618.1 - 8.8e-07 28.7 0.0 3.9e-06 26.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Ank PF00023.25 KOO36618.1 - 9.4e-07 28.3 3.4 0.009 15.7 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 KOO36618.1 - 9.5e-06 25.7 6.4 0.0001 22.4 0.7 3.4 1 1 2 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO36618.1 - 3.2e-05 24.1 2.8 9.3e-05 22.6 1.9 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO36618.1 - 0.00018 21.4 3.1 0.2 11.9 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 KOO36618.1 - 0.016 15.7 0.7 0.56 10.7 0.0 2.8 3 1 0 3 3 3 0 Ankyrin repeats (many copies) HHH_5 PF14520.1 KOO36618.1 - 0.032 14.3 0.1 0.17 12.0 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix domain Lipase_GDSL_2 PF13472.1 KOO36620.1 - 0.0085 16.2 0.2 0.013 15.6 0.1 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 KOO36620.1 - 0.06 13.1 0.0 0.061 13.1 0.0 1.1 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.1 KOO36620.1 - 0.12 12.1 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family UQ_con PF00179.21 KOO36621.1 - 1.7e-43 147.4 0.0 1.8e-43 147.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KOO36621.1 - 5e-06 26.3 0.0 5.6e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 KOO36621.1 - 0.026 14.4 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 RWD domain Pkinase PF00069.20 KOO36623.1 - 2.8e-49 167.6 0.0 6.3e-49 166.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO36623.1 - 1.4e-46 158.7 0.0 2e-46 158.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO36623.1 - 5.2e-06 26.3 1.1 0.034 13.8 0.0 3.4 3 0 0 3 3 3 2 Phosphotransferase enzyme family ACT PF01842.20 KOO36623.1 - 8.6e-05 21.9 0.1 0.0002 20.7 0.1 1.5 1 0 0 1 1 1 1 ACT domain Kinase-like PF14531.1 KOO36623.1 - 0.00014 20.9 0.0 0.00022 20.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOO36623.1 - 0.003 16.6 0.0 0.0054 15.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ACT_4 PF13291.1 KOO36623.1 - 0.14 12.5 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 ACT domain adh_short PF00106.20 KOO36692.1 - 1.8e-05 24.7 0.0 3e-05 23.9 0.0 1.4 2 0 0 2 2 2 1 short chain dehydrogenase Glycos_transf_3 PF00591.16 KOO36694.1 - 0.074 12.4 0.8 0.084 12.2 0.6 1.2 1 0 0 1 1 1 0 Glycosyl transferase family, a/b domain Strabismus PF06638.6 KOO36694.1 - 0.11 10.8 1.1 0.13 10.5 0.8 1.1 1 0 0 1 1 1 0 Strabismus protein Herpes_UL35 PF04496.7 KOO36694.1 - 0.24 11.6 2.1 0.33 11.2 0.2 2.0 1 1 1 2 2 2 0 Herpesvirus UL35 family Hemerythrin PF01814.18 KOO36694.1 - 0.41 10.8 7.3 0.42 10.7 1.3 2.2 1 1 1 2 2 2 0 Hemerythrin HHE cation binding domain TarH PF02203.10 KOO36694.1 - 0.52 10.1 6.1 0.72 9.6 4.2 1.4 1 1 0 1 1 1 0 Tar ligand binding domain homologue FlgN PF05130.7 KOO36694.1 - 0.61 10.3 3.7 1.6 8.9 2.3 1.7 1 1 1 2 2 2 0 FlgN protein Lipase_chap PF03280.9 KOO36694.1 - 1.5 8.3 6.7 1.2 8.6 1.3 2.7 2 1 2 4 4 4 0 Proteobacterial lipase chaperone protein LTXXQ PF07813.7 KOO36694.1 - 5.6 7.4 7.2 21 5.6 2.0 2.5 1 1 1 2 2 2 0 LTXXQ motif family protein Tyr-DNA_phospho PF06087.7 KOO36695.1 - 7.6e-10 37.9 0.0 5e-08 32.0 0.0 2.1 1 1 1 2 2 2 2 Tyrosyl-DNA phosphodiesterase WWE PF02825.15 KOO36695.1 - 0.00016 21.0 0.0 0.00029 20.1 0.0 1.4 1 0 0 1 1 1 1 WWE domain Fib_alpha PF08702.5 KOO36696.1 - 0.0071 16.4 5.6 0.0071 16.4 3.9 7.1 2 1 8 10 10 10 2 Fibrinogen alpha/beta chain family PDZ PF00595.19 KOO36697.1 - 0.00021 21.3 0.0 0.43 10.8 0.1 2.5 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO36697.1 - 0.11 12.3 0.0 5.4 6.9 0.0 2.5 2 1 0 2 2 2 0 PDZ domain Cellulase PF00150.13 KOO36699.1 - 3.8e-18 65.6 0.0 1.1e-17 64.1 0.0 1.7 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_1 PF00232.13 KOO36699.1 - 0.00089 17.5 0.0 0.0014 16.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Glyco_hydro_42 PF02449.10 KOO36699.1 - 0.0015 17.7 0.0 0.015 14.4 0.0 2.1 2 0 0 2 2 2 1 Beta-galactosidase Cellulase-like PF12876.2 KOO36699.1 - 0.089 13.2 0.0 0.28 11.6 0.0 1.8 1 0 0 1 1 1 0 Sugar-binding cellulase-like CHASE PF03924.8 KOO36701.1 - 0.025 13.7 0.0 0.54 9.4 0.0 2.8 2 1 0 2 2 2 0 CHASE domain EGF_alliinase PF04863.8 KOO36776.1 - 0.59 10.1 5.2 1.8 8.6 3.6 1.8 1 0 0 1 1 1 0 Alliinase EGF-like domain DEAD PF00270.24 KOO36777.1 - 1.9e-13 50.2 0.0 3e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Phage_CII PF05269.6 KOO36777.1 - 0.023 14.6 0.0 0.077 13.0 0.0 1.9 1 0 0 1 1 1 0 Bacteriophage CII protein NAD_binding_10 PF13460.1 KOO36779.1 - 4.6e-20 72.3 1.8 1.1e-16 61.3 1.3 3.1 1 1 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 KOO36779.1 - 0.007 15.6 0.0 0.028 13.6 0.0 1.9 1 1 0 1 1 1 1 NmrA-like family DAHP_synth_2 PF01474.11 KOO36780.1 - 8.3e-147 489.0 0.0 1.4e-146 488.2 0.0 1.3 1 1 0 1 1 1 1 Class-II DAHP synthetase family Sel1 PF08238.7 KOO37054.1 - 4e-14 52.6 10.1 1.7e-07 31.6 1.1 4.0 4 0 0 4 4 4 2 Sel1 repeat U-box PF04564.10 KOO37054.1 - 2.8e-11 43.2 0.0 5e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.3 KOO37054.1 - 0.00039 19.8 0.0 0.00071 19.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit TPR_6 PF13174.1 KOO37054.1 - 0.14 12.6 3.4 0.88 10.1 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_60s PF00428.14 KOO37059.1 - 0.022 15.1 0.1 0.058 13.8 0.1 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein TBCA PF02970.11 KOO37061.1 - 0.084 12.9 0.3 2.7 8.1 0.0 2.3 2 0 0 2 2 2 0 Tubulin binding cofactor A SET PF00856.23 KOO37062.1 - 1.4e-13 51.4 0.1 3.8e-13 50.0 0.0 1.7 1 1 0 1 1 1 1 SET domain SAF PF08666.7 KOO37062.1 - 0.005 17.2 0.1 0.2 12.0 0.0 2.5 2 0 0 2 2 2 1 SAF domain AA_permease_2 PF13520.1 KOO37064.1 - 2.2e-32 112.1 24.3 3.3e-32 111.5 16.9 1.3 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 KOO37064.1 - 1.8e-13 49.6 22.7 2.7e-13 49.0 15.7 1.2 1 0 0 1 1 1 1 Amino acid permease EF-hand_4 PF12763.2 KOO37064.1 - 3.2e-09 36.4 0.0 5.9e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.27 KOO37064.1 - 0.0023 17.1 0.0 0.0091 15.2 0.0 2.1 2 0 0 2 2 2 1 EF hand PH PF00169.24 KOO37064.1 - 0.011 15.8 0.0 0.036 14.2 0.0 1.9 1 1 0 1 1 1 0 PH domain EF-hand_7 PF13499.1 KOO37064.1 - 0.097 12.8 0.0 0.28 11.3 0.0 1.8 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.1 KOO37064.1 - 0.12 12.3 0.0 0.54 10.2 0.0 2.2 1 0 0 1 1 1 0 EF-hand domain CRAL_TRIO PF00650.15 KOO37065.1 - 2e-21 76.1 0.0 2.8e-21 75.6 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain MCPVI PF02993.9 KOO37065.1 - 3.1 7.8 5.0 5 7.2 3.5 1.2 1 0 0 1 1 1 0 Minor capsid protein VI Ank_2 PF12796.2 KOO37067.1 - 6.5e-84 276.3 55.7 2.8e-20 72.4 4.0 6.3 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank PF00023.25 KOO37067.1 - 7.5e-77 249.5 39.8 6.2e-09 35.2 0.1 12.0 12 0 0 12 12 12 10 Ankyrin repeat Ank_4 PF13637.1 KOO37067.1 - 2.9e-60 199.6 19.8 4e-10 39.9 0.1 8.0 3 2 5 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO37067.1 - 2.3e-52 169.7 14.3 2.9e-05 23.8 0.0 10.5 11 0 0 11 11 10 9 Ankyrin repeat Ank_5 PF13857.1 KOO37067.1 - 1.5e-47 158.5 30.9 3.1e-09 36.7 0.1 9.1 2 1 6 9 9 9 8 Ankyrin repeats (many copies) U-box PF04564.10 KOO37067.1 - 8.6e-11 41.6 0.0 1.7e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 U-box domain Mic1 PF07035.7 KOO37067.1 - 0.0016 17.8 6.3 3.8 6.8 0.1 4.3 1 1 5 6 6 6 3 Colon cancer-associated protein Mic1-like zf-Nse PF11789.3 KOO37067.1 - 0.0021 17.5 0.0 0.0039 16.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit DUF1973 PF09315.6 KOO37067.1 - 0.0025 17.2 10.4 0.56 9.6 0.7 5.7 1 1 3 5 5 5 1 Domain of unknown function (DUF1973) Ser_hydrolase PF06821.8 KOO37067.1 - 0.012 15.2 22.1 0.041 13.4 0.8 5.7 1 1 4 6 6 6 0 Serine hydrolase FrhB_FdhB_N PF04422.8 KOO37067.1 - 0.12 12.2 1.7 0.64 9.9 0.1 3.0 3 0 0 3 3 3 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term GFO_IDH_MocA PF01408.17 KOO37067.1 - 0.33 11.4 4.9 1.4 9.4 0.1 3.9 2 2 1 3 3 3 0 Oxidoreductase family, NAD-binding Rossmann fold Exotox-A_target PF09102.5 KOO37067.1 - 0.33 10.4 5.4 0.58 9.6 0.4 2.8 1 1 2 3 3 3 0 Exotoxin A, targeting VBS PF08913.5 KOO37067.1 - 0.71 10.1 14.6 16 5.7 0.2 4.4 1 1 3 4 4 4 0 Vinculin Binding Site PCP_red PF08369.5 KOO37067.1 - 2.3 8.1 6.4 1e+02 2.8 0.0 5.9 8 0 0 8 8 8 0 Proto-chlorophyllide reductase 57 kD subunit PP_kinase_C PF13090.1 KOO37067.1 - 4.7 5.7 13.7 11 4.4 0.1 5.1 2 2 5 7 7 7 0 Polyphosphate kinase C-terminal domain Fer2_4 PF13510.1 KOO37067.1 - 6.5 6.6 6.8 17 5.2 0.2 3.9 3 2 1 4 4 3 0 2Fe-2S iron-sulfur cluster binding domain ARL2_Bind_BART PF11527.3 KOO37068.1 - 2.8e-31 107.8 0.0 4.7e-31 107.0 0.0 1.3 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART Ank PF00023.25 KOO37068.1 - 6.8e-08 31.9 0.0 7.8e-05 22.2 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 KOO37068.1 - 1.8e-07 31.1 0.0 7.1e-07 29.2 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO37068.1 - 2.9e-07 30.7 0.0 6.7e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO37068.1 - 4.2e-06 26.4 0.0 5.7e-05 22.9 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.1 KOO37068.1 - 1.5e-05 25.3 0.0 0.00024 21.5 0.0 2.8 3 0 0 3 3 3 1 Ankyrin repeats (many copies) AhpC-TSA PF00578.16 KOO37069.1 - 1.1e-10 41.2 0.0 4.1e-10 39.4 0.0 1.8 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 KOO37069.1 - 7.2e-06 25.6 0.2 1.9e-05 24.2 0.1 1.6 1 1 0 1 1 1 1 Redoxin ABC1 PF03109.11 KOO37070.1 - 7.8e-29 100.0 0.0 2e-28 98.7 0.0 1.7 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 KOO37070.1 - 4.1e-06 26.7 7.0 5.4e-05 23.0 0.0 3.8 3 1 1 4 4 4 1 Phosphotransferase enzyme family RIO1 PF01163.17 KOO37070.1 - 0.0022 17.4 0.0 0.028 13.7 0.0 2.1 2 0 0 2 2 2 1 RIO1 family Pkinase PF00069.20 KOO37070.1 - 0.055 12.6 0.0 0.73 8.9 0.0 2.1 2 0 0 2 2 2 0 Protein kinase domain Methyltransf_26 PF13659.1 KOO37071.1 - 0.63 10.0 4.1 1.4 8.9 2.5 1.7 1 1 0 1 1 1 0 Methyltransferase domain DUF4432 PF14486.1 KOO37076.1 - 2.7e-101 338.1 0.0 3.3e-101 337.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4432) Abhydrolase_6 PF12697.2 KOO37077.1 - 3e-14 53.4 1.4 3e-14 53.4 1.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO37077.1 - 1.1e-08 34.9 0.1 2.7e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO37077.1 - 2.9e-08 33.5 0.0 5.4e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 KOO37077.1 - 0.0087 15.3 0.0 2.6 7.1 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Acyltransferase PF01553.16 KOO37077.1 - 0.073 12.5 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 Acyltransferase zf-C3HC4_2 PF13923.1 KOO37078.1 - 0.00093 19.1 2.8 0.00093 19.1 2.0 2.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO37078.1 - 0.0066 16.1 8.5 0.0066 16.1 5.9 3.0 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) TIP120 PF08623.5 KOO37081.1 - 4e-50 169.6 0.8 1.8e-48 164.3 0.3 3.4 4 0 0 4 4 4 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.1 KOO37081.1 - 2.5e-15 56.5 24.1 0.001 19.3 0.0 7.7 4 2 3 8 8 8 5 HEAT repeats Adaptin_N PF01602.15 KOO37081.1 - 4.5e-09 35.1 6.7 0.00014 20.3 5.1 4.0 3 1 1 4 4 4 3 Adaptin N terminal region HEAT PF02985.17 KOO37081.1 - 6.5e-09 35.1 25.1 0.13 12.3 0.0 11.4 12 1 1 13 13 13 4 HEAT repeat HEAT_EZ PF13513.1 KOO37081.1 - 1.9e-05 24.9 48.6 0.16 12.4 0.1 12.6 5 4 10 15 15 15 4 HEAT-like repeat Cnd1 PF12717.2 KOO37081.1 - 0.00014 21.7 1.9 4.4 7.1 0.1 5.0 4 1 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Ipi1_N PF12333.3 KOO37081.1 - 0.0047 16.8 2.1 1.2 9.1 0.0 4.4 4 0 0 4 4 4 1 Rix1 complex component involved in 60S ribosome maturation HEAT_2 PF13646.1 KOO37082.1 - 2.9e-05 24.2 2.9 1 9.6 0.5 3.8 2 1 0 3 3 3 2 HEAT repeats Cnd1 PF12717.2 KOO37082.1 - 0.0011 18.8 0.1 0.98 9.2 0.0 2.4 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 MMS19_N PF14500.1 KOO37082.1 - 0.0053 16.0 1.6 1.6 7.9 0.0 2.8 2 1 1 3 3 3 2 Dos2-interacting transcription regulator of RNA-Pol-II FANCI_S2 PF14676.1 KOO37082.1 - 0.0082 16.0 0.2 0.52 10.1 0.1 2.7 1 1 1 2 2 2 1 FANCI solenoid 2 HEAT PF02985.17 KOO37082.1 - 0.01 15.8 9.2 0.046 13.8 0.1 4.9 6 0 0 6 6 6 0 HEAT repeat Xpo1 PF08389.7 KOO37082.1 - 0.013 15.4 0.0 8.7 6.2 0.0 3.0 3 0 0 3 3 3 0 Exportin 1-like protein Adaptin_N PF01602.15 KOO37082.1 - 0.014 13.7 0.1 0.03 12.6 0.1 1.4 1 1 0 1 1 1 0 Adaptin N terminal region HEAT_EZ PF13513.1 KOO37082.1 - 0.026 15.0 3.8 26 5.4 0.1 4.4 4 0 0 4 4 4 0 HEAT-like repeat MMS19_C PF12460.3 KOO37082.1 - 0.061 12.0 0.1 19 3.8 0.1 3.0 2 1 1 3 3 3 0 RNAPII transcription regulator C-terminal UME PF08064.8 KOO37082.1 - 0.065 13.1 0.6 2.3 8.2 0.1 2.9 2 1 2 4 4 4 0 UME (NUC010) domain CENP-B_dimeris PF09026.5 KOO37082.1 - 0.9 9.8 8.4 1.8 8.8 5.8 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PKD_channel PF08016.7 KOO40304.1 - 2.2e-57 194.3 4.0 3.8e-57 193.6 2.7 1.4 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.26 KOO40304.1 - 3.9e-11 42.5 25.3 3.9e-11 42.5 17.5 2.0 2 0 0 2 2 2 1 Ion transport protein Ni_hydr_CYTB PF01292.15 KOO40304.1 - 0.11 11.9 5.4 0.3 10.4 3.7 1.8 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 DDE_Tnp_1_6 PF13751.1 KOO40347.1 - 1 9.4 4.8 3.6 7.6 0.2 2.4 1 1 1 2 2 2 0 Transposase DDE domain CRAL_TRIO PF00650.15 KOO40348.1 - 1.7e-14 53.5 0.0 2.9e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 KOO40348.1 - 0.0054 16.8 0.0 0.0095 16.0 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain LRR_5 PF13306.1 KOO40349.1 - 1.7e-96 318.7 0.0 2.9e-35 120.7 0.1 2.7 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO40349.1 - 9.8e-21 73.2 0.2 4e-05 23.2 0.0 5.9 2 1 6 8 8 8 7 Leucine rich repeat Skp1 PF01466.14 KOO40349.1 - 0.19 11.7 0.0 0.32 11.0 0.0 1.3 1 0 0 1 1 1 0 Skp1 family, dimerisation domain LRR_5 PF13306.1 KOO40350.1 - 1.2e-97 322.5 0.1 2.4e-39 133.9 0.0 3.4 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO40350.1 - 3.2e-31 106.8 0.1 6.2e-06 25.8 0.0 6.7 2 1 7 9 9 9 8 Leucine rich repeat He_PIG PF05345.7 KOO40350.1 - 0.045 13.7 17.0 67 3.6 0.1 8.8 10 0 0 10 10 10 0 Putative Ig domain DUF1358 PF07096.6 KOO40350.1 - 0.047 13.3 0.7 0.19 11.4 0.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1358) Fork_head_N PF08430.7 KOO40350.1 - 0.93 9.8 14.9 51 4.2 4.8 3.4 1 1 1 2 2 2 0 Forkhead N-terminal region 2OG-FeII_Oxy_3 PF13640.1 KOO40351.1 - 1.2e-08 35.3 0.1 2.5e-08 34.3 0.1 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RHIM PF12721.2 KOO40351.1 - 3.4 8.1 0.0 3.4 8.1 0.0 3.0 4 0 0 4 4 4 0 RIP homotypic interaction motif AAA_17 PF13207.1 KOO40402.1 - 1.7e-07 32.0 0.9 1.1e-05 26.1 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.1 KOO40402.1 - 1.3e-05 25.1 0.1 1.3e-05 25.1 0.1 3.1 3 1 1 4 4 4 1 AAA domain Zeta_toxin PF06414.7 KOO40402.1 - 0.00039 19.5 0.1 0.0014 17.8 0.0 1.9 2 0 0 2 2 2 1 Zeta toxin APS_kinase PF01583.15 KOO40402.1 - 0.0038 16.8 0.8 0.0087 15.7 0.1 1.8 2 0 0 2 2 2 1 Adenylylsulphate kinase G-alpha PF00503.15 KOO40402.1 - 0.0071 15.0 0.0 0.0081 14.8 0.0 1.2 1 0 0 1 1 1 1 G-protein alpha subunit T2SE PF00437.15 KOO40402.1 - 0.03 13.2 1.4 0.041 12.7 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_18 PF13238.1 KOO40402.1 - 0.035 14.3 0.1 0.035 14.3 0.1 2.4 3 0 0 3 3 3 0 AAA domain DUF258 PF03193.11 KOO40402.1 - 0.043 13.0 0.1 0.078 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 KOO40402.1 - 0.055 12.9 0.1 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Cytidylate_kin2 PF13189.1 KOO40402.1 - 0.082 12.8 0.0 0.77 9.6 0.0 2.3 1 1 1 2 2 2 0 Cytidylate kinase-like family AAA_16 PF13191.1 KOO40402.1 - 0.091 12.7 0.1 0.091 12.7 0.1 2.7 3 0 0 3 3 3 0 AAA ATPase domain AAA_28 PF13521.1 KOO40402.1 - 0.1 12.5 0.2 0.24 11.3 0.2 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 KOO40402.1 - 0.11 12.8 0.5 0.32 11.2 0.0 1.9 2 0 0 2 2 2 0 ABC transporter AAA_22 PF13401.1 KOO40402.1 - 0.15 12.2 3.9 0.94 9.6 0.1 3.3 2 2 2 4 4 4 0 AAA domain Rad17 PF03215.10 KOO40402.1 - 0.2 10.2 0.0 0.32 9.6 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein DUF563 PF04577.9 KOO40403.1 - 2.1e-13 50.6 0.2 3.5e-13 49.9 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Pkinase PF00069.20 KOO40404.1 - 2.1e-47 161.4 0.0 3.2e-47 160.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO40404.1 - 7.6e-43 146.4 0.0 2.2e-42 144.9 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.2 KOO40404.1 - 1.4e-28 99.0 0.2 5.3e-15 55.5 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO40404.1 - 5.4e-23 79.6 0.6 1.2e-05 24.8 0.0 5.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.1 KOO40404.1 - 1.6e-18 66.7 0.1 9.1e-07 29.2 0.0 4.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO40404.1 - 2.8e-15 55.9 0.7 8.1e-07 29.0 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO40404.1 - 1.2e-12 46.7 0.1 0.01 15.9 0.0 5.0 4 0 0 4 4 4 3 Ankyrin repeat APH PF01636.18 KOO40404.1 - 0.0003 20.6 0.4 0.0082 15.8 0.0 2.5 3 0 0 3 3 3 1 Phosphotransferase enzyme family EF-hand_7 PF13499.1 KOO40407.1 - 3.1e-24 84.8 7.7 3.4e-11 43.1 0.1 3.7 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO40407.1 - 5.5e-23 78.4 5.0 0.00016 20.6 0.1 6.4 6 0 0 6 6 6 4 EF hand EF-hand_6 PF13405.1 KOO40407.1 - 1.6e-22 77.2 11.1 0.00019 21.0 0.0 7.1 7 0 0 7 7 7 4 EF-hand domain EF-hand_8 PF13833.1 KOO40407.1 - 9.2e-18 63.6 8.8 9.1e-07 28.4 0.1 5.2 3 2 2 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.1 KOO40407.1 - 5.5e-13 47.6 13.5 0.00037 19.6 0.0 5.6 5 0 0 5 5 5 3 EF hand SPARC_Ca_bdg PF10591.4 KOO40407.1 - 0.00019 21.4 0.1 2.4 8.2 0.0 4.4 4 2 0 4 4 4 1 Secreted protein acidic and rich in cysteine Ca binding region TAFH PF07531.9 KOO40407.1 - 0.038 13.6 0.0 14 5.4 0.0 2.9 3 0 0 3 3 3 0 NHR1 homology to TAF Peptidase_C26 PF07722.8 KOO40408.1 - 3.6e-21 75.6 0.0 2.2e-20 73.0 0.0 2.2 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.23 KOO40408.1 - 2.1e-07 30.5 0.0 4.3e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Cupin_8 PF13621.1 KOO40409.1 - 0.1 12.0 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Cupin-like domain ERAP1_C PF11838.3 KOO40683.1 - 0.048 12.8 2.1 0.064 12.5 1.4 1.2 1 0 0 1 1 1 0 ERAP1-like C-terminal domain Matrilin_ccoil PF10393.4 KOO40683.1 - 0.15 11.4 0.8 0.24 10.8 0.6 1.3 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin GcrA PF07750.6 KOO40683.1 - 0.21 11.7 1.9 0.41 10.8 0.7 1.9 2 0 0 2 2 2 0 GcrA cell cycle regulator DUF3138 PF11336.3 KOO40683.1 - 1 7.4 8.1 1.9 6.5 5.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) N6-adenineMlase PF10237.4 KOO40684.1 - 9.8e-29 100.0 0.0 1.5e-28 99.5 0.0 1.3 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase Nucleotid_trans PF03407.11 KOO40684.1 - 7.8e-14 51.9 0.0 3.1e-13 50.0 0.0 1.7 1 1 0 2 2 2 1 Nucleotide-diphospho-sugar transferase Tmemb_185A PF10269.4 KOO40685.1 - 4.8e-06 26.3 2.3 8.5e-06 25.5 1.6 1.3 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein ResIII PF04851.10 KOO40685.1 - 0.00033 20.5 0.0 0.95 9.2 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DUF2075 PF09848.4 KOO40685.1 - 0.0018 17.3 0.0 0.003 16.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) UvrD_C_2 PF13538.1 KOO40685.1 - 0.0063 16.6 0.0 0.02 15.0 0.0 1.9 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain DEAD PF00270.24 KOO40685.1 - 0.0082 15.6 0.0 0.025 14.0 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase LAM_C PF12544.3 KOO40685.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Lysine-2,3-aminomutase ACT_5 PF13710.1 KOO40685.1 - 0.13 12.0 0.0 0.59 9.9 0.0 2.2 1 0 0 1 1 1 0 ACT domain RAP1 PF07218.6 KOO40685.1 - 0.99 7.4 4.7 1.9 6.5 3.2 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PABP PF00658.13 KOO40835.1 - 2.5e-08 33.4 0.0 7.1e-08 32.0 0.0 1.8 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain DUF3399 PF11879.3 KOO41263.1 - 4.4 7.5 11.3 12 6.1 3.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3399) zf-C2H2 PF00096.21 KOO41264.1 - 4.6e-32 108.4 53.3 1.4e-05 25.1 1.7 6.3 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 KOO41264.1 - 2e-31 106.7 47.8 1e-07 31.8 1.5 7.0 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2_4 PF13894.1 KOO41264.1 - 1.8e-23 81.0 43.5 0.00062 19.9 1.1 6.5 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_6 PF13912.1 KOO41264.1 - 5.6e-12 45.1 29.9 0.024 14.5 0.2 6.5 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KOO41264.1 - 4.2e-06 26.7 29.3 0.064 13.4 0.5 6.5 6 0 0 6 6 6 4 Zinc-finger double-stranded RNA-binding CHORD PF04968.7 KOO41264.1 - 0.1 12.8 42.2 1.1 9.5 0.7 6.3 2 2 4 6 6 6 0 CHORD zf-met PF12874.2 KOO41264.1 - 0.28 11.4 19.9 0.58 10.4 0.2 6.0 6 0 0 6 6 6 0 Zinc-finger of C2H2 type Tankyrase_bdg_C PF15327.1 KOO41264.1 - 1.1 9.4 8.6 0.98 9.5 0.3 2.8 2 1 1 3 3 3 0 Tankyrase binding protein C terminal domain Skp1 PF01466.14 KOO41265.1 - 0.016 15.1 0.0 0.039 13.9 0.0 1.6 1 0 0 1 1 1 0 Skp1 family, dimerisation domain LRR_6 PF13516.1 KOO41266.1 - 1.9e-10 39.7 1.3 0.00038 20.2 0.0 3.5 3 0 0 3 3 3 3 Leucine Rich repeat LRR_1 PF00560.28 KOO41266.1 - 0.043 13.8 0.0 6.1 7.2 0.0 2.7 3 0 0 3 3 3 0 Leucine Rich Repeat BicD PF09730.4 KOO41267.1 - 0.05 11.9 36.6 0.064 11.6 6.8 2.1 1 1 1 2 2 2 0 Microtubule-associated protein Bicaudal-D AAA_27 PF13514.1 KOO41267.1 - 2.5 5.6 64.8 0.011 13.4 17.9 2.0 1 1 1 2 2 2 0 AAA domain Galactosyl_T PF01762.16 KOO41268.1 - 7.6e-06 25.6 0.0 2.5e-05 23.9 0.0 1.9 1 1 0 1 1 1 1 Galactosyltransferase NLPC_P60 PF00877.14 KOO41268.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 NlpC/P60 family PsbH PF00737.15 KOO41874.1 - 0.56 9.8 8.3 2 8.0 0.0 3.7 2 1 1 3 3 3 0 Photosystem II 10 kDa phosphoprotein Spc7_N PF15402.1 KOO41877.1 - 2e-08 32.7 0.3 2.3e-08 32.5 0.2 1.0 1 0 0 1 1 1 1 N-terminus of kinetochore NMS complex subunit Spc7 BSD PF03909.12 KOO41878.1 - 0.00075 19.1 0.0 0.0026 17.4 0.0 2.0 1 0 0 1 1 1 1 BSD domain UVR PF02151.14 KOO41878.1 - 0.0014 18.0 1.7 0.0014 18.0 1.2 2.2 2 0 0 2 2 2 1 UvrB/uvrC motif DUF3142 PF11340.3 KOO41878.1 - 0.022 14.4 0.2 13 5.4 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3142) Mrr_N PF14338.1 KOO41878.1 - 0.26 11.3 8.5 1.2 9.2 0.1 3.4 3 0 0 3 3 3 0 Mrr N-terminal domain Transaldolase PF00923.14 KOO41879.1 - 4.8e-76 255.6 0.0 1e-75 254.5 0.0 1.5 1 1 0 1 1 1 1 Transaldolase Peptidase_C54 PF03416.14 KOO41880.1 - 1.7e-36 125.8 0.0 2.1e-36 125.5 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 UAA PF08449.6 KOO41881.1 - 2.6e-08 33.1 12.1 3.5e-08 32.7 8.4 1.1 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 KOO41881.1 - 1e-06 28.4 10.0 1e-06 28.4 7.0 2.5 3 0 0 3 3 3 1 Triose-phosphate Transporter family EamA PF00892.15 KOO41881.1 - 0.085 12.9 24.7 0.15 12.0 5.2 2.2 2 0 0 2 2 2 0 EamA-like transporter family SET_assoc PF11767.3 KOO41958.1 - 0.086 12.1 0.0 11 5.4 0.0 2.3 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated Pkinase PF00069.20 KOO42294.1 - 1e-51 175.5 0.0 1.3e-51 175.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO42294.1 - 1.9e-22 79.5 0.0 2.7e-22 79.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO42294.1 - 0.0048 15.8 0.0 0.013 14.4 0.0 1.7 1 1 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 KOO42294.1 - 0.018 14.4 0.0 0.038 13.3 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Methyltransf_26 PF13659.1 KOO42295.1 - 4.5e-18 65.3 1.1 4.5e-18 65.3 0.8 1.6 2 0 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.10 KOO42295.1 - 1.7e-06 27.5 0.0 2.6e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_31 PF13847.1 KOO42295.1 - 3.9e-06 26.5 0.0 5.3e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 KOO42295.1 - 5.5e-06 26.0 0.0 9e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 MTS PF05175.9 KOO42295.1 - 2.7e-05 23.5 0.0 3.9e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.2 KOO42295.1 - 7.2e-05 23.3 0.0 0.00014 22.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 KOO42295.1 - 0.0002 20.6 0.0 0.00026 20.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltrans_SAM PF10672.4 KOO42295.1 - 0.026 13.3 0.0 0.044 12.6 0.0 1.3 1 0 0 1 1 1 0 S-adenosylmethionine-dependent methyltransferase N6_N4_Mtase PF01555.13 KOO42295.1 - 0.074 12.5 0.0 1.3 8.4 0.0 2.0 2 0 0 2 2 2 0 DNA methylase N6_Mtase PF02384.11 KOO42295.1 - 0.12 11.4 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 N-6 DNA Methylase PIF1 PF05970.9 KOO42296.1 - 4.8e-52 177.1 1.3 6.2e-40 137.2 0.1 2.9 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.1 KOO42296.1 - 3.1e-17 62.8 0.1 1.1e-16 61.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 KOO42296.1 - 1.3e-09 38.2 0.1 3e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 KOO42296.1 - 2.4e-06 27.1 1.1 2.4e-06 27.1 0.8 2.0 2 0 0 2 2 2 1 Part of AAA domain AAA_11 PF13086.1 KOO42296.1 - 1.9e-05 24.3 1.0 0.0037 16.8 0.0 2.4 1 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 KOO42296.1 - 0.00025 21.1 2.6 0.0025 17.8 0.0 3.0 3 1 0 4 4 4 1 AAA ATPase domain Mg_chelatase PF01078.16 KOO42296.1 - 0.0004 19.5 0.1 0.00074 18.7 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI UvrD-helicase PF00580.16 KOO42296.1 - 0.00076 18.8 0.6 0.0011 18.3 0.4 1.2 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain T2SE PF00437.15 KOO42296.1 - 0.00079 18.4 0.0 0.0015 17.4 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein DEAD PF00270.24 KOO42296.1 - 0.0023 17.4 0.3 1.6 8.1 0.0 2.4 1 1 1 2 2 2 2 DEAD/DEAH box helicase PhoH PF02562.11 KOO42296.1 - 0.0056 15.9 0.3 0.014 14.6 0.2 1.7 2 0 0 2 2 2 1 PhoH-like protein Helicase_RecD PF05127.9 KOO42296.1 - 0.0062 16.1 0.4 0.056 13.0 0.3 2.1 1 1 0 1 1 1 1 Helicase AAA PF00004.24 KOO42296.1 - 0.0066 16.6 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TrwB_AAD_bind PF10412.4 KOO42296.1 - 0.0073 14.9 0.3 0.013 14.1 0.2 1.3 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain AAA_29 PF13555.1 KOO42296.1 - 0.011 15.2 0.0 0.028 13.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.9 KOO42296.1 - 0.014 15.0 0.0 0.029 14.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Hpr_kinase_C PF07475.7 KOO42296.1 - 0.028 13.7 0.1 0.044 13.0 0.1 1.2 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain DUF2075 PF09848.4 KOO42296.1 - 0.04 12.9 0.1 0.059 12.3 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.10 KOO42296.1 - 0.043 13.5 0.3 0.34 10.5 0.0 2.4 2 1 1 3 3 3 0 NTPase NACHT PF05729.7 KOO42296.1 - 0.053 13.1 0.0 0.15 11.7 0.0 1.8 1 0 0 1 1 1 0 NACHT domain AAA_32 PF13654.1 KOO42296.1 - 0.056 12.0 0.0 0.083 11.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 KOO42296.1 - 0.058 12.8 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA-like domain RNA_helicase PF00910.17 KOO42296.1 - 0.073 13.2 0.0 0.15 12.2 0.0 1.6 1 1 0 1 1 1 0 RNA helicase AAA_14 PF13173.1 KOO42296.1 - 0.097 12.5 0.0 0.34 10.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain DAP3 PF10236.4 KOO42296.1 - 0.13 11.1 0.1 0.28 10.0 0.0 1.5 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 ABC_tran PF00005.22 KOO42296.1 - 0.13 12.5 0.1 0.23 11.7 0.1 1.4 1 0 0 1 1 1 0 ABC transporter PapC_C PF13953.1 KOO42604.1 - 0.031 13.9 0.1 3.9 7.2 0.0 2.5 2 0 0 2 2 2 0 PapC C-terminal domain LRR_5 PF13306.1 KOO42683.1 - 5.8e-123 404.3 0.1 6e-42 142.4 0.0 2.6 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO42683.1 - 3.5e-34 116.3 0.0 1.4e-05 24.7 0.0 6.3 2 1 7 9 9 9 8 Leucine rich repeat Fork_head_N PF08430.7 KOO42683.1 - 0.08 13.3 9.2 1.8 8.9 3.1 3.1 1 1 0 2 2 2 0 Forkhead N-terminal region He_PIG PF05345.7 KOO42683.1 - 0.47 10.5 16.1 1e+02 3.0 0.0 7.6 7 1 1 8 8 8 0 Putative Ig domain ADK PF00406.17 KOO42685.1 - 6.2e-53 178.7 0.0 8.3e-53 178.3 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 KOO42685.1 - 5.9e-10 38.6 0.1 3.3e-08 33.0 0.0 2.7 1 1 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.1 KOO42685.1 - 7.3e-05 22.6 0.0 0.00014 21.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO42685.1 - 0.00036 21.3 0.0 0.00068 20.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 KOO42685.1 - 0.00042 19.4 0.0 0.00065 18.8 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.1 KOO42685.1 - 0.061 13.6 0.0 0.15 12.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain EF-hand_7 PF13499.1 KOO43075.1 - 2.1e-22 79.0 20.6 1.2e-08 34.8 1.0 4.8 2 1 3 5 5 5 5 EF-hand domain pair EF-hand_1 PF00036.27 KOO43075.1 - 1.4e-21 74.0 27.9 1.2e-05 24.2 0.3 6.7 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.1 KOO43075.1 - 2e-18 64.5 23.3 0.00032 20.3 0.1 6.8 6 0 0 6 6 6 6 EF-hand domain EF-hand_8 PF13833.1 KOO43075.1 - 1.2e-16 60.0 6.9 1.2e-06 28.0 0.1 4.3 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO43075.1 - 2.5e-11 42.3 27.1 0.0024 17.1 0.2 6.6 6 0 0 6 6 6 5 EF hand Rhv PF00073.15 KOO43075.1 - 0.34 10.5 0.0 34 4.0 0.0 4.0 4 0 0 4 4 4 0 picornavirus capsid protein DAGAT PF03982.8 KOO43076.1 - 7.3e-29 100.3 0.0 2.6e-28 98.5 0.0 1.7 2 0 0 2 2 2 1 Diacylglycerol acyltransferase PsbQ PF05757.6 KOO43077.1 - 0.0042 16.5 3.3 0.0057 16.0 0.4 2.0 2 0 0 2 2 2 1 Oxygen evolving enhancer protein 3 (PsbQ) PRP38 PF03371.10 KOO43088.1 - 1.3e-54 184.4 0.0 1.7e-54 184.0 0.0 1.1 1 0 0 1 1 1 1 PRP38 family eRF1_1 PF03463.10 KOO43089.1 - 1.8e-36 124.6 0.0 2.3e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.10 KOO43089.1 - 1.1e-10 41.8 0.0 1.9e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 ParcG PF10274.4 KOO43090.1 - 3.3e-27 95.5 0.0 4.1e-27 95.2 0.0 1.1 1 0 0 1 1 1 1 Parkin co-regulated protein NDK PF00334.14 KOO43091.1 - 1.6e-06 27.9 0.0 0.00017 21.3 0.0 2.1 1 1 1 2 2 2 2 Nucleoside diphosphate kinase CD52 PF15116.1 KOO43434.1 - 0.13 12.0 1.7 8.5 6.2 0.0 3.3 3 0 0 3 3 3 0 CAMPATH-1 antigen PDZ PF00595.19 KOO43557.1 - 8.1e-09 35.5 0.0 0.00049 20.2 0.0 2.2 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) Tricorn_PDZ PF14685.1 KOO43557.1 - 0.0022 17.7 0.0 2.1 8.1 0.0 2.5 2 1 0 2 2 2 2 Tricorn protease PDZ domain PDZ_2 PF13180.1 KOO43557.1 - 0.04 13.7 0.0 0.27 11.1 0.0 2.1 2 0 0 2 2 2 0 PDZ domain DUF4366 PF14283.1 KOO43557.1 - 0.082 12.3 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) SHOCT PF09851.4 KOO43559.1 - 6.7e-06 25.3 6.4 9.1e-06 24.9 4.4 1.2 1 0 0 1 1 1 1 Short C-terminal domain GvpG PF05120.7 KOO43559.1 - 0.032 14.0 0.1 0.051 13.3 0.0 1.2 1 0 0 1 1 1 0 Gas vesicle protein G Mito_carr PF00153.22 KOO43560.1 - 1.4e-65 217.0 2.3 2.3e-20 72.0 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.1 KOO43560.1 - 3.6e-19 68.6 0.1 4.3e-10 39.5 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO43560.1 - 2.5e-14 51.4 0.1 0.00012 21.1 0.5 4.3 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.1 KOO43560.1 - 6.3e-13 48.1 0.2 7.3e-05 22.3 0.1 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.1 KOO43560.1 - 1.4e-12 46.3 0.6 0.0051 16.5 0.0 4.0 3 1 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.1 KOO43560.1 - 3e-11 42.1 0.6 0.00026 20.1 0.2 3.4 3 0 0 3 3 3 3 EF hand SPARC_Ca_bdg PF10591.4 KOO43560.1 - 0.00028 20.8 0.0 0.036 14.1 0.0 2.3 1 1 2 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO43560.1 - 0.011 15.3 0.0 4.8 6.9 0.0 2.3 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Kunitz_BPTI PF00014.18 KOO43561.1 - 2.3 8.4 7.5 21 5.4 0.1 3.4 3 0 0 3 3 3 0 Kunitz/Bovine pancreatic trypsin inhibitor domain UVR PF02151.14 KOO43760.1 - 6.1e-11 41.4 27.1 0.00017 20.9 4.0 3.5 3 0 0 3 3 3 3 UvrB/uvrC motif DUF1090 PF06476.7 KOO43760.1 - 0.12 12.0 15.3 0.3 10.7 5.8 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1090) Lipoprotein_11 PF03260.8 KOO43760.1 - 0.33 9.9 6.7 4.3 6.2 0.1 2.9 1 1 2 3 3 3 0 Lepidopteran low molecular weight (30 kD) lipoprotein Reductase_C PF14759.1 KOO43760.1 - 0.74 10.1 4.4 3.5 7.9 0.2 2.9 1 1 2 3 3 3 0 Reductase C-terminal PhoU_div PF01865.11 KOO43760.1 - 0.88 8.6 9.7 10 5.2 0.1 3.0 1 1 1 3 3 3 0 Protein of unknown function DUF47 DUF4404 PF14357.1 KOO43760.1 - 7.7 7.0 10.1 11 6.5 2.4 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4404) FCD PF07729.7 KOO43760.1 - 8.1 6.7 17.3 11 6.4 0.5 3.2 1 1 2 3 3 3 0 FCD domain TRM13 PF05206.9 KOO43761.1 - 2.2e-60 204.1 0.0 5.1e-44 150.4 0.0 2.0 2 0 0 2 2 2 2 Methyltransferase TRM13 Methyltransf_32 PF13679.1 KOO43761.1 - 1.1e-05 25.1 0.4 2e-05 24.2 0.3 1.5 1 0 0 1 1 1 1 Methyltransferase domain FAP PF07174.6 KOO43761.1 - 0.73 9.0 17.9 1.5 8.0 12.4 1.5 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) His_Phos_1 PF00300.17 KOO43762.1 - 2e-13 50.7 0.0 3.3e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Peptidase_S8 PF00082.17 KOO44189.1 - 8.7e-31 107.1 9.7 1.6e-28 99.7 6.7 2.4 1 1 0 1 1 1 1 Subtilase family P_proprotein PF01483.15 KOO44189.1 - 3.4e-09 36.3 0.1 4.5e-08 32.7 0.0 2.3 2 0 0 2 2 2 1 Proprotein convertase P-domain Toxin_37 PF11415.3 KOO44193.1 - 0.068 12.8 0.8 0.12 12.0 0.6 1.4 1 0 0 1 1 1 0 Antifungal peptide termicin DUF1823 PF08853.6 KOO44196.1 - 4.3e-24 84.4 0.4 1.9e-23 82.3 0.3 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF1823) PH PF00169.24 KOO44196.1 - 6.2e-09 36.0 0.0 1.2e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 PH domain ABC2_membrane_3 PF12698.2 KOO44197.1 - 5.6e-48 163.7 34.9 6.6e-32 110.8 9.9 3.1 4 0 0 4 4 3 2 ABC-2 family transporter protein ABC_tran PF00005.22 KOO44197.1 - 8.5e-47 158.8 0.0 1.1e-22 80.7 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 KOO44197.1 - 8.7e-20 71.8 0.0 9.9e-06 25.7 0.0 4.3 4 0 0 4 4 4 3 AAA domain SbcCD_C PF13558.1 KOO44197.1 - 0.00022 21.1 0.0 1 9.3 0.0 3.2 2 1 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.1 KOO44197.1 - 0.00028 21.2 2.9 0.0094 16.2 0.1 2.2 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.17 KOO44197.1 - 0.0033 16.8 1.6 1.2 8.5 0.1 2.3 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain AAA_29 PF13555.1 KOO44197.1 - 0.0048 16.3 2.8 0.078 12.5 0.2 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain SMC_N PF02463.14 KOO44197.1 - 0.03 13.5 0.0 3.6 6.7 0.0 2.7 3 1 0 3 3 3 0 RecF/RecN/SMC N terminal domain DUF258 PF03193.11 KOO44197.1 - 0.58 9.3 0.2 3.6 6.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_15 PF13175.1 KOO44197.1 - 1.7 7.6 0.0 7.5 5.4 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain DUF3584 PF12128.3 KOO44197.1 - 5.8 4.1 2.9 17 2.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) UDPGP PF01704.13 KOO44198.1 - 8.8e-89 297.9 0.0 1.2e-88 297.4 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Dpy-30 PF05186.8 KOO44198.1 - 9.8e-05 21.7 0.1 0.00037 19.9 0.0 2.0 2 0 0 2 2 2 1 Dpy-30 motif EF-hand_1 PF00036.27 KOO44199.1 - 3.6e-11 41.5 2.9 2.9e-06 26.1 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO44199.1 - 3.3e-10 38.9 0.8 0.00014 21.4 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO44199.1 - 1.6e-08 34.0 5.2 1.5e-06 27.7 0.1 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.1 KOO44199.1 - 7.9e-08 32.3 5.6 7.6e-07 29.1 0.9 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO44199.1 - 4.5e-07 28.9 1.9 0.0027 16.9 0.2 2.5 2 0 0 2 2 2 2 EF hand DUF2442 PF10387.4 KOO44199.1 - 0.0048 16.8 1.0 0.059 13.3 0.2 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2442) Barttin PF15462.1 KOO44199.1 - 0.044 13.4 0.0 0.056 13.0 0.0 1.1 1 0 0 1 1 1 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) ADH_zinc_N PF00107.21 KOO44200.1 - 4.9e-11 42.2 0.8 1.3e-10 40.8 0.2 2.0 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ADH_N PF08240.7 KOO44200.1 - 0.00023 20.8 0.1 0.0019 17.9 0.1 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain KR PF08659.5 KOO44200.1 - 0.00076 19.1 0.5 0.0015 18.2 0.4 1.5 1 0 0 1 1 1 1 KR domain adh_short PF00106.20 KOO44200.1 - 0.00091 19.1 3.7 0.0018 18.1 2.6 1.6 1 0 0 1 1 1 1 short chain dehydrogenase ADH_zinc_N_2 PF13602.1 KOO44200.1 - 0.012 16.5 0.0 0.029 15.2 0.0 1.8 1 0 0 1 1 1 0 Zinc-binding dehydrogenase YjeF_N PF03853.10 KOO44200.1 - 0.023 14.2 0.8 0.035 13.7 0.6 1.2 1 0 0 1 1 1 0 YjeF-related protein N-terminus NAD_binding_10 PF13460.1 KOO44200.1 - 0.038 14.0 2.0 0.074 13.0 1.4 1.6 1 0 0 1 1 1 0 NADH(P)-binding NmrA PF05368.8 KOO44200.1 - 0.17 11.1 0.6 0.25 10.5 0.4 1.3 1 0 0 1 1 1 0 NmrA-like family C2 PF00168.25 KOO44201.1 - 1.2e-19 69.8 0.0 3.1e-18 65.3 0.0 2.2 2 0 0 2 2 2 1 C2 domain Nuc_sug_transp PF04142.10 KOO44202.1 - 1.8e-45 154.9 5.0 2.9e-45 154.3 3.5 1.3 1 0 0 1 1 1 1 Nucleotide-sugar transporter TPT PF03151.11 KOO44202.1 - 0.00038 20.1 0.0 0.00038 20.1 0.0 3.1 2 1 0 2 2 2 1 Triose-phosphate Transporter family DUF4133 PF13571.1 KOO44202.1 - 0.00072 19.7 2.3 0.44 10.7 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4133) EmrE PF13536.1 KOO44202.1 - 0.0016 18.6 3.0 0.0016 18.6 2.1 2.5 2 0 0 2 2 2 1 Multidrug resistance efflux transporter UAA PF08449.6 KOO44202.1 - 0.002 17.1 7.9 0.011 14.7 5.5 2.1 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.15 KOO44202.1 - 0.0025 17.8 4.4 0.0025 17.8 3.1 2.4 2 0 0 2 2 2 1 EamA-like transporter family ATG16 PF08614.6 KOO44203.1 - 0.89 9.3 29.6 0.39 10.5 4.8 3.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) AAA_13 PF13166.1 KOO44203.1 - 4.8 5.5 16.7 2.9 6.2 1.4 2.0 1 1 1 2 2 2 0 AAA domain OAD_gamma PF04277.8 KOO44203.1 - 4.8 7.6 5.7 1.6 9.1 1.4 2.1 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain NACHT PF05729.7 KOO44367.1 - 0.0037 16.9 0.1 0.0089 15.6 0.0 1.7 1 0 0 1 1 1 1 NACHT domain RRM_1 PF00076.17 KOO44367.1 - 0.25 11.0 0.0 0.85 9.2 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PcF PF09461.5 KOO45985.1 - 0.054 13.3 0.1 0.17 11.8 0.1 1.8 1 0 0 1 1 1 0 Phytotoxin PcF protein PABP PF00658.13 KOO45985.1 - 0.083 12.5 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 Poly-adenylate binding protein, unique domain Ank_2 PF12796.2 KOO45986.1 - 4.2e-91 299.4 52.5 8.4e-19 67.7 0.7 5.6 1 1 8 9 9 9 8 Ankyrin repeats (3 copies) Ank PF00023.25 KOO45986.1 - 9e-37 123.0 35.9 3.3e-05 23.4 0.3 9.5 10 0 0 10 10 10 8 Ankyrin repeat Ank_4 PF13637.1 KOO45986.1 - 1.6e-35 120.8 16.3 9.9e-08 32.2 0.0 6.9 4 2 4 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO45986.1 - 3.3e-31 106.5 25.6 2.7e-08 33.7 0.8 8.4 2 1 7 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO45986.1 - 4.7e-20 69.6 17.4 0.017 15.2 0.0 9.5 10 0 0 10 10 10 6 Ankyrin repeat Ank_2 PF12796.2 KOO45987.1 - 7.1e-190 616.0 131.3 1.1e-18 67.2 1.0 10.7 1 1 15 16 16 16 15 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO45987.1 - 4.7e-90 294.5 29.8 2.6e-09 37.3 0.0 13.0 9 3 5 14 14 14 13 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO45987.1 - 1.2e-86 282.7 65.5 3.9e-10 39.6 0.4 17.3 2 2 14 17 17 17 17 Ankyrin repeats (many copies) Ank PF00023.25 KOO45987.1 - 1.1e-85 277.4 100.9 5.4e-07 29.1 0.0 21.0 21 0 0 21 21 21 19 Ankyrin repeat Ank_3 PF13606.1 KOO45987.1 - 6.2e-42 137.4 43.0 0.00059 19.8 0.0 19.6 19 0 0 19 19 19 14 Ankyrin repeat DUF4182 PF13790.1 KOO45987.1 - 1.8e-06 27.6 11.8 1.6 8.5 0.0 9.7 11 0 0 11 11 11 1 Domain of unknown function (DUF4182) Involucrin_N PF10583.4 KOO45987.1 - 0.0015 18.7 0.2 19 5.6 0.0 6.7 8 0 0 8 8 8 0 Involucrin of squamous epithelia N-terminus LTD PF00932.14 KOO45987.1 - 0.0088 16.1 2.4 57 3.8 0.0 5.6 4 4 2 6 6 6 0 Lamin Tail Domain ScpA_ScpB PF02616.9 KOO45987.1 - 0.27 10.7 0.9 0.55 9.7 0.7 1.4 1 0 0 1 1 1 0 ScpA/B protein SAM_adeno_trans PF01887.11 KOO45989.1 - 0.54 9.2 14.5 6.3 5.7 0.0 5.0 1 1 5 6 6 6 0 S-adenosyl-l-methionine hydroxide adenosyltransferase Mg_trans_NIPA PF05653.9 KOO45990.1 - 3.3e-15 55.8 10.1 4.5e-15 55.3 7.0 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA Ribosomal_L50 PF10501.4 KOO45991.1 - 3e-06 27.1 0.0 4.1e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal subunit 39S DUF1918 PF08940.6 KOO45991.1 - 0.14 11.5 0.0 0.28 10.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) DUF3082 PF11282.3 KOO45992.1 - 8.6e-06 25.7 2.7 1.3e-05 25.1 1.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3082) SspB PF04386.8 KOO45992.1 - 0.073 12.6 0.6 0.13 11.8 0.0 1.6 2 0 0 2 2 2 0 Stringent starvation protein B Bac_export_2 PF01312.14 KOO45992.1 - 0.093 11.6 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family 2OG-FeII_Oxy_3 PF13640.1 KOO45993.1 - 0.0011 19.4 0.6 0.015 15.7 0.4 2.6 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily HeH PF12949.2 KOO45993.1 - 0.12 11.9 0.0 0.26 10.8 0.0 1.6 1 0 0 1 1 1 0 HeH/LEM domain Ish1 PF10281.4 KOO45993.1 - 0.19 11.8 0.0 0.39 10.8 0.0 1.5 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein Costars PF14705.1 KOO45995.1 - 0.091 12.7 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Costars LRR_6 PF13516.1 KOO45997.1 - 0.091 12.8 0.0 48 4.4 0.0 3.4 2 0 0 2 2 2 0 Leucine Rich repeat VacA2 PF03077.9 KOO45997.1 - 0.1 12.2 0.6 7.9 6.1 0.1 2.5 2 0 0 2 2 2 0 Putative vacuolating cytotoxin LRR_7 PF13504.1 KOO45997.1 - 0.14 12.4 0.1 73 4.2 0.0 3.4 3 0 0 3 3 3 0 Leucine rich repeat mTERF PF02536.9 KOO45999.1 - 1e-14 53.9 0.0 1.3e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 mTERF Gp_dh_C PF02800.15 KOO46000.1 - 5.4e-65 217.6 0.1 1e-64 216.7 0.1 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 KOO46000.1 - 1.1e-53 181.1 0.0 2.6e-53 180.0 0.0 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.14 KOO46000.1 - 0.091 11.9 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ENTH PF01417.15 KOO46001.1 - 6.2e-20 71.3 0.1 8.8e-20 70.8 0.1 1.1 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.11 KOO46001.1 - 3.8e-05 22.5 0.0 4.8e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.15 KOO46002.1 - 0.00069 19.4 0.1 0.0011 18.8 0.0 1.4 2 0 0 2 2 2 1 ENTH domain Lambda_tail_I PF06805.7 KOO46002.1 - 0.12 12.2 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage lambda tail assembly protein I P53_C PF11619.3 KOO46002.1 - 0.13 12.0 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 Transcription factor P53 - C terminal domain EF-hand_7 PF13499.1 KOO46004.1 - 4.2e-08 33.1 0.9 0.012 15.7 0.1 3.5 2 2 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO46004.1 - 3.5e-07 29.5 4.5 0.0052 16.5 0.1 3.4 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.27 KOO46004.1 - 1.7e-06 26.9 7.9 0.0048 16.1 0.3 3.9 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.1 KOO46004.1 - 5.7e-05 22.6 4.3 0.37 10.4 0.1 3.5 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO46004.1 - 0.00064 18.9 2.3 0.12 11.7 0.2 3.2 3 0 0 3 3 3 2 EF hand Dus PF01207.12 KOO46006.1 - 1.2e-47 162.2 0.0 1.6e-47 161.8 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.16 KOO46006.1 - 7.3e-05 22.1 0.0 0.00014 21.2 0.0 1.4 1 1 0 1 1 1 1 Histidine biosynthesis protein zf-CCCH PF00642.19 KOO46006.1 - 0.0039 16.8 0.3 0.0089 15.6 0.2 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) UFC1 PF08694.6 KOO46007.1 - 3.7e-68 228.0 0.1 4.5e-68 227.7 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.17 KOO46007.1 - 0.11 12.4 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 RWD domain Filament PF00038.16 KOO46008.1 - 0.031 13.7 0.7 0.059 12.8 0.5 1.4 1 0 0 1 1 1 0 Intermediate filament protein Kinesin PF00225.18 KOO46009.1 - 1.7e-26 92.7 0.0 2e-12 46.4 0.0 2.0 2 0 0 2 2 2 2 Kinesin motor domain AAA_16 PF13191.1 KOO46009.1 - 0.02 14.8 0.0 3 7.7 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain EF-hand_8 PF13833.1 KOO46010.1 - 1.4e-09 37.4 1.7 1.1e-05 24.9 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO46010.1 - 2.7e-09 36.1 4.0 0.0013 18.4 0.4 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.27 KOO46010.1 - 3.1e-09 35.4 4.4 0.00021 20.3 0.4 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO46010.1 - 4.8e-09 36.2 2.8 0.00093 19.2 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO46010.1 - 6.6e-05 22.0 10.8 0.0068 15.7 0.8 2.8 3 0 0 3 3 3 2 EF hand Thioredoxin PF00085.15 KOO46010.1 - 0.00073 19.1 0.1 0.12 12.0 0.0 3.6 4 0 0 4 4 4 1 Thioredoxin HGD-D PF06050.8 KOO46010.1 - 0.0012 17.7 3.4 0.0025 16.7 2.4 1.4 1 0 0 1 1 1 1 2-hydroxyglutaryl-CoA dehydratase, D-component EF-hand_like PF09279.6 KOO46010.1 - 0.11 12.5 2.6 1.3 9.1 0.0 2.8 2 0 0 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like Borrelia_P83 PF05262.6 KOO46010.1 - 0.83 7.8 20.9 1.3 7.1 14.5 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Mod_r PF07200.8 KOO46010.1 - 3 7.7 17.4 2.7 7.8 9.1 2.4 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein ATP-synt_G PF04718.10 KOO46010.1 - 8.5 7.0 7.9 4.4 8.0 0.0 2.6 2 0 0 2 2 2 0 Mitochondrial ATP synthase g subunit Rotamase_2 PF13145.1 KOO46010.1 - 9.3 6.9 22.0 4.5 7.9 9.1 3.5 3 0 0 3 3 3 0 PPIC-type PPIASE domain Arm PF00514.18 KOO46011.1 - 9.6e-31 104.5 0.5 3.7e-12 45.5 0.0 3.9 4 0 0 4 4 4 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO46011.1 - 8.3e-08 32.4 0.0 0.00018 21.6 0.0 3.0 1 1 1 2 2 2 2 HEAT repeats HEAT_EZ PF13513.1 KOO46011.1 - 4.8e-05 23.7 0.0 0.0076 16.7 0.0 2.8 1 1 2 3 3 3 3 HEAT-like repeat EF-hand_8 PF13833.1 KOO46710.1 - 2.5e-05 23.8 0.0 2.9e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair KaiC PF06745.8 KOO46710.1 - 0.14 11.2 0.0 0.17 10.9 0.0 1.0 1 0 0 1 1 1 0 KaiC Arm PF00514.18 KOO46730.1 - 0.16 11.8 6.2 14 5.6 0.2 4.6 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat TRAP_beta PF05753.9 KOO46732.1 - 3.5e-19 68.6 0.0 4.4e-19 68.3 0.0 1.1 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) DUF11 PF01345.13 KOO46732.1 - 0.083 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF11 WD40 PF00400.27 KOO46733.1 - 6.6e-10 38.4 0.2 0.012 15.5 0.0 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat PQQ_3 PF13570.1 KOO46733.1 - 0.022 15.0 7.8 1.3 9.3 0.4 3.5 3 0 0 3 3 3 0 PQQ-like domain HEAT_2 PF13646.1 KOO47051.1 - 8e-29 99.7 38.5 2.8e-09 37.1 2.8 6.7 4 2 3 7 7 7 5 HEAT repeats HEAT PF02985.17 KOO47051.1 - 1.8e-17 61.7 17.3 0.19 11.8 0.0 10.1 9 0 0 9 9 9 7 HEAT repeat HEAT_EZ PF13513.1 KOO47051.1 - 2.2e-12 47.0 38.2 0.094 13.2 0.1 10.5 11 0 0 11 11 11 6 HEAT-like repeat ADPrib_exo_Tox PF03496.9 KOO47051.1 - 8.7e-08 31.5 0.0 3.8e-07 29.5 0.0 2.0 2 1 0 2 2 2 1 ADP-ribosyltransferase exoenzyme ART PF01129.13 KOO47051.1 - 1.4e-06 27.5 0.0 4.3e-06 25.9 0.0 1.7 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase Cohesin_HEAT PF12765.2 KOO47051.1 - 4.9e-05 23.1 53.6 0.019 14.9 0.4 9.2 9 0 0 9 9 9 5 HEAT repeat associated with sister chromatid cohesion Cnd1 PF12717.2 KOO47051.1 - 5.7e-05 23.0 1.1 23 4.7 0.1 6.0 2 2 5 7 7 7 0 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.15 KOO47051.1 - 0.0016 16.8 0.0 0.034 12.4 0.0 2.3 1 1 0 1 1 1 1 Adaptin N terminal region FliL PF03748.9 KOO47051.1 - 0.12 12.3 0.1 74 3.4 0.0 4.3 2 2 5 7 7 7 0 Flagellar basal body-associated protein FliL Pox_Ag35 PF03286.9 KOO47052.1 - 0.013 15.0 0.4 0.025 14.0 0.3 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RXT2_N PF08595.6 KOO47052.1 - 0.061 13.1 0.6 0.098 12.4 0.4 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF4608 PF15381.1 KOO47052.1 - 0.16 12.1 0.7 6.1 7.0 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4608) Glyco_hydro_18 PF00704.23 KOO47056.1 - 0.059 12.8 0.1 0.079 12.3 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 18 Ion_trans_2 PF07885.11 KOO47153.1 - 7.4e-21 73.6 11.3 2.8e-11 42.9 1.3 2.3 2 0 0 2 2 2 2 Ion channel EF-hand_1 PF00036.27 KOO47153.1 - 4.4e-13 47.5 6.4 4.9e-05 22.3 0.0 4.3 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.1 KOO47153.1 - 9.6e-13 48.0 0.0 6.7e-09 35.7 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO47153.1 - 2.1e-12 45.8 0.4 0.00088 18.9 0.0 3.8 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.1 KOO47153.1 - 1.1e-10 40.3 1.7 0.00017 20.7 0.0 3.7 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO47153.1 - 8.7e-08 31.6 4.0 0.0037 16.8 0.0 3.4 3 1 1 4 4 4 2 EF-hand domain pair Ion_trans PF00520.26 KOO47153.1 - 0.037 13.2 3.9 1.8 7.8 0.4 2.3 2 0 0 2 2 2 0 Ion transport protein zf-Apc11 PF12861.2 KOO47154.1 - 0.17 11.7 0.1 0.42 10.4 0.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger MMR_HSR1 PF01926.18 KOO47155.1 - 3.1e-17 62.6 0.0 5e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GRIP PF01465.15 KOO47155.1 - 1e-06 28.1 0.0 1.7e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 GRIP domain FeoB_N PF02421.13 KOO47155.1 - 3.3e-06 26.4 0.0 5.4e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 KOO47155.1 - 8.7e-06 25.6 0.0 0.012 15.4 0.1 2.2 2 0 0 2 2 2 2 Dynamin family GTP_EFTU PF00009.22 KOO47155.1 - 0.0027 17.1 0.0 0.14 11.5 0.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.5 KOO47155.1 - 0.0029 16.8 0.0 0.0056 15.9 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit DUF258 PF03193.11 KOO47155.1 - 0.014 14.6 0.0 0.048 12.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF258 ABC_tran PF00005.22 KOO47155.1 - 0.016 15.4 0.0 0.034 14.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter IIGP PF05049.8 KOO47155.1 - 0.017 13.9 0.0 0.024 13.4 0.0 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_29 PF13555.1 KOO47155.1 - 0.032 13.7 0.0 0.059 12.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.1 KOO47155.1 - 0.1 12.5 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain Ank_4 PF13637.1 KOO47156.1 - 4.1e-25 87.6 3.8 2.5e-11 43.7 0.3 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO47156.1 - 2.1e-20 72.8 0.1 5.3e-12 45.9 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO47156.1 - 2.1e-18 65.1 0.4 2e-07 30.4 0.0 3.9 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.1 KOO47156.1 - 2.2e-17 62.6 1.5 9.6e-13 47.9 0.4 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO47156.1 - 1.3e-11 43.4 0.1 8.8e-05 22.3 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat GLTP PF08718.6 KOO47172.1 - 2.4e-17 63.3 0.0 3.1e-17 62.9 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) TPR_10 PF13374.1 KOO47172.1 - 0.0074 16.1 0.4 1.4 8.9 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat CaATP_NAI PF12515.3 KOO47172.1 - 0.036 13.5 0.1 0.12 11.9 0.0 1.8 2 0 0 2 2 2 0 Ca2+-ATPase N terminal autoinhibitory domain Glutaminase PF04960.10 KOO47172.1 - 0.12 11.3 0.0 0.17 10.7 0.0 1.2 1 0 0 1 1 1 0 Glutaminase Mating_N PF12731.2 KOO47172.1 - 0.14 12.0 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Mating-type protein beta 1 DnaJ PF00226.26 KOO47173.1 - 1.3e-17 63.2 0.2 2.4e-17 62.4 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ-X PF14308.1 KOO47173.1 - 1.6e-16 60.2 0.1 8.7e-16 57.8 0.1 1.9 1 1 0 1 1 1 1 X-domain of DnaJ-containing Trefoil PF00088.13 KOO47176.1 - 0.1 12.2 1.4 0.18 11.4 1.0 1.3 1 0 0 1 1 1 0 Trefoil (P-type) domain VCBS PF13517.1 KOO47441.1 - 6e-35 119.4 25.9 4.4e-15 55.7 4.2 3.3 1 1 2 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO47441.1 - 2.1e-24 84.5 32.9 3.4e-06 26.5 2.4 4.4 4 0 0 4 4 4 4 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO47441.1 - 2.1e-12 46.8 10.2 0.0019 17.6 0.0 4.0 1 1 3 4 4 4 4 Insecticide toxin TcdB middle/N-terminal region EF-hand_5 PF13202.1 KOO47441.1 - 0.00056 19.1 20.8 1.8 8.0 0.7 4.6 4 0 0 4 4 4 4 EF hand EF-hand_1 PF00036.27 KOO47441.1 - 0.0079 15.4 12.9 6.8 6.2 0.1 4.4 4 0 0 4 4 4 3 EF hand DUF1150 PF06620.6 KOO47441.1 - 0.031 14.1 0.0 12 5.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1150) BBS2_Mid PF14783.1 KOO47441.1 - 0.031 14.0 1.8 27 4.5 0.0 3.8 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region YuzL PF14115.1 KOO47441.1 - 0.044 14.0 0.7 79 3.6 0.0 3.9 4 0 0 4 4 4 0 YuzL-like protein Asp-B-Hydro_N PF05279.6 KOO47441.1 - 0.23 11.2 17.2 11 5.8 0.2 4.1 4 0 0 4 4 4 0 Aspartyl beta-hydroxylase N-terminal region Excalibur PF05901.6 KOO47441.1 - 0.79 10.1 6.2 1.6e+02 2.7 0.0 4.1 4 0 0 4 4 4 0 Excalibur calcium-binding domain LON PF02190.11 KOO47443.1 - 8.5e-08 32.1 0.0 2.1e-06 27.5 0.0 2.2 2 0 0 2 2 2 2 ATP-dependent protease La (LON) domain PAE PF03283.8 KOO47707.1 - 1.2e-67 228.1 1.0 2.7e-67 226.9 0.0 1.8 1 1 0 2 2 2 1 Pectinacetylesterase Somatomedin_B PF01033.12 KOO47707.1 - 4.5e-07 29.7 15.9 4.5e-07 29.7 11.0 2.1 2 0 0 2 2 2 1 Somatomedin B domain Peptidase_S9 PF00326.16 KOO47707.1 - 0.011 14.9 0.1 0.022 14.0 0.1 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family Ank_4 PF13637.1 KOO47708.1 - 6.6e-19 67.8 0.2 1.7e-07 31.5 0.0 3.4 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.2 KOO47708.1 - 4.6e-16 58.9 2.5 2e-15 56.9 0.1 2.5 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO47708.1 - 2.7e-14 52.1 2.0 6.5e-06 25.7 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.1 KOO47708.1 - 1.3e-13 49.7 0.5 0.00018 21.4 0.0 4.7 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.1 KOO47708.1 - 9.8e-12 44.7 6.1 4.2e-07 30.0 0.3 3.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Pkinase PF00069.20 KOO47709.1 - 3.5e-48 164.0 0.0 5e-48 163.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO47709.1 - 2.2e-39 135.0 0.0 4e-39 134.2 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO47709.1 - 0.00026 20.0 0.0 0.00039 19.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Shisa PF13908.1 KOO47709.1 - 1.6 8.9 9.8 12 6.0 0.1 3.0 3 0 0 3 3 3 0 Wnt and FGF inhibitory regulator LRR_6 PF13516.1 KOO47710.1 - 4.8e-31 103.3 3.2 4.4e-05 23.1 0.0 6.3 6 0 0 6 6 6 5 Leucine Rich repeat LRR_1 PF00560.28 KOO47710.1 - 0.0013 18.4 0.0 51 4.4 0.0 5.0 5 1 0 5 5 5 0 Leucine Rich Repeat LRR_4 PF12799.2 KOO47710.1 - 0.005 16.4 6.7 0.46 10.1 0.1 4.2 2 1 0 4 4 4 1 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO47710.1 - 0.012 15.6 4.3 59 4.5 0.0 5.4 6 0 0 6 6 6 0 Leucine rich repeat CbiG_N PF11760.3 KOO47710.1 - 0.1 12.2 13.5 10 5.9 0.0 5.1 3 1 2 5 5 5 0 Cobalamin synthesis G N-terminal SpoU_sub_bind PF08032.7 KOO47710.1 - 0.52 10.5 4.0 6 7.1 0.1 3.1 3 2 0 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding PI3Ka PF00613.15 KOO48198.1 - 2.3e-48 163.8 0.5 4.5e-48 162.8 0.4 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.22 KOO48198.1 - 3.3e-46 157.6 0.3 2e-44 151.8 0.1 2.9 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.19 KOO48198.1 - 7.7e-14 51.6 0.0 1.5e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 TRAM_LAG1_CLN8 PF03798.11 KOO48553.1 - 4.2e-10 39.4 22.4 5e-10 39.2 15.5 1.1 1 0 0 1 1 1 1 TLC domain DUF2763 PF10961.3 KOO48553.1 - 1.9 8.9 3.6 1.8 8.9 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2763) GWT1 PF06423.7 KOO48553.1 - 2.4 8.2 6.5 7 6.7 4.5 2.0 1 1 0 1 1 1 0 GWT1 ABC2_membrane_4 PF12730.2 KOO48553.1 - 4.7 6.2 14.6 0.86 8.7 4.4 2.2 1 1 0 2 2 2 0 ABC-2 family transporter protein DUF4124 PF13511.1 KOO48554.1 - 0.082 12.9 0.3 0.32 11.0 0.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4124) Endonuclea_NS_2 PF13930.1 KOO48554.1 - 0.11 12.5 1.1 0.18 11.8 0.8 1.3 1 0 0 1 1 1 0 DNA/RNA non-specific endonuclease DUF3602 PF12223.3 KOO48554.1 - 2.4 8.6 9.7 1.2 9.5 0.6 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3602) zf-RING_2 PF13639.1 KOO48555.1 - 3.5e-15 55.5 5.0 3.5e-15 55.5 3.5 2.0 2 0 0 2 2 1 1 Ring finger domain zf-rbx1 PF12678.2 KOO48555.1 - 1.1e-09 38.1 2.6 3e-09 36.8 1.8 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 KOO48555.1 - 1.7e-08 33.9 3.1 4.5e-08 32.6 2.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO48555.1 - 2.2e-06 27.5 5.0 2.2e-06 27.5 3.5 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO48555.1 - 0.00046 19.7 2.2 0.00046 19.7 1.5 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO48555.1 - 0.0013 18.4 3.6 0.0013 18.4 2.5 1.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-Apc11 PF12861.2 KOO48555.1 - 0.0014 18.3 5.2 0.0021 17.8 2.1 2.4 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.3 KOO48555.1 - 0.0035 17.2 6.8 0.0039 17.1 3.1 2.3 2 1 0 2 2 2 1 FANCL C-terminal domain RINGv PF12906.2 KOO48555.1 - 0.051 13.6 1.9 0.17 11.9 1.3 2.0 1 1 0 1 1 1 0 RING-variant domain zf-RING_UBOX PF13445.1 KOO48555.1 - 0.22 11.2 3.6 0.37 10.5 0.8 2.4 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4_4 PF15227.1 KOO48555.1 - 0.25 11.2 8.4 0.041 13.7 2.6 2.3 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.1 KOO48555.1 - 1.1 8.9 4.6 2.5 7.7 3.2 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Malic_M PF03949.10 KOO48557.1 - 3.8e-78 262.5 0.1 4.8e-78 262.2 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.14 KOO48557.1 - 9.7e-67 224.0 0.0 2.1e-66 222.9 0.0 1.6 2 0 0 2 2 2 1 Malic enzyme, N-terminal domain Pyr_redox_2 PF07992.9 KOO48557.1 - 0.069 13.0 0.4 0.13 12.1 0.3 1.5 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 KOO48557.1 - 0.28 10.8 0.8 0.47 10.0 0.5 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pro-rich PF15240.1 KOO48558.1 - 0.00023 21.3 31.2 0.00035 20.7 21.6 1.3 1 0 0 1 1 1 1 Proline-rich DUF1846 PF08903.6 KOO48558.1 - 0.11 10.9 0.0 0.15 10.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1846) ABC1 PF03109.11 KOO48643.1 - 4e-21 75.1 0.0 7.4e-21 74.3 0.0 1.5 1 0 0 1 1 1 1 ABC1 family SCP2 PF02036.12 KOO48643.1 - 0.0013 19.0 0.0 0.0037 17.5 0.0 1.9 1 0 0 1 1 1 1 SCP-2 sterol transfer family PX PF00787.19 KOO48643.1 - 0.0013 18.4 0.0 0.0028 17.4 0.0 1.5 1 0 0 1 1 1 1 PX domain SAP PF02037.22 KOO48644.1 - 1.3e-07 30.8 0.0 1.7e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 SAP domain Mod_r PF07200.8 KOO48645.1 - 0.0018 18.2 6.1 0.083 12.8 1.0 2.3 1 1 1 2 2 2 2 Modifier of rudimentary (Mod(r)) protein DUF4201 PF13870.1 KOO48645.1 - 0.034 13.5 12.5 0.054 12.9 8.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) DUF3348 PF11828.3 KOO48645.1 - 0.042 13.2 11.7 0.063 12.6 8.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3348) Mto2_bdg PF12808.2 KOO48645.1 - 0.047 13.8 10.7 0.1 12.7 0.1 3.8 2 1 2 4 4 4 0 Micro-tubular organiser Mto1 C-term Mto2-binding region COG5 PF10392.4 KOO48645.1 - 0.069 13.1 7.3 0.78 9.6 1.1 2.4 1 1 1 2 2 2 0 Golgi transport complex subunit 5 CCDC92 PF14916.1 KOO48645.1 - 0.07 12.7 3.6 0.22 11.1 0.4 2.9 1 1 2 3 3 3 0 Coiled-coil domain of unknown function Cep57_CLD_2 PF14197.1 KOO48645.1 - 0.12 12.3 14.4 1.6 8.7 8.3 3.0 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 NYD-SP28_assoc PF14775.1 KOO48645.1 - 0.12 12.0 1.7 14 5.4 0.1 2.7 2 0 0 2 2 2 0 Sperm tail C-terminal domain DUF630 PF04783.7 KOO48645.1 - 0.24 11.3 3.1 1.2 9.1 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF630) DUF3450 PF11932.3 KOO48645.1 - 0.28 10.4 7.5 0.38 9.9 1.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Vps51 PF08700.6 KOO48645.1 - 0.5 10.2 8.1 1.2 9.0 0.7 2.7 3 1 0 3 3 3 0 Vps51/Vps67 DUF904 PF06005.7 KOO48645.1 - 0.55 10.5 10.3 7 7.0 3.7 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF904) IncA PF04156.9 KOO48645.1 - 0.62 9.6 11.8 5.6 6.5 8.2 2.0 1 1 0 1 1 1 0 IncA protein DUF4570 PF15134.1 KOO48645.1 - 2 8.2 15.2 0.55 10.0 6.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4570) HALZ PF02183.13 KOO48645.1 - 2.9 7.6 6.7 8.3 6.2 0.4 3.2 3 0 0 3 3 3 0 Homeobox associated leucine zipper DUF972 PF06156.8 KOO48645.1 - 3.1 8.1 8.7 1.8 8.9 0.8 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF972) Herpes_UL6 PF01763.11 KOO48645.1 - 3.6 5.6 9.7 1.2 7.2 1.7 2.0 1 1 1 2 2 2 0 Herpesvirus UL6 like TMF_DNA_bd PF12329.3 KOO48645.1 - 4 7.3 10.0 5.7 6.8 0.6 2.6 2 1 1 3 3 2 0 TATA element modulatory factor 1 DNA binding DivIVA PF05103.8 KOO48645.1 - 4.2 7.4 13.4 0.16 11.9 3.4 2.1 1 1 1 2 2 2 0 DivIVA protein Spc24 PF08286.6 KOO48645.1 - 8 6.1 7.5 6 6.6 0.5 2.4 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 PIP5K PF01504.13 KOO48646.1 - 1.2e-44 152.3 0.0 1.5e-38 132.3 0.0 2.1 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase FAT PF02259.18 KOO48647.1 - 0.087 11.7 0.1 0.12 11.3 0.0 1.1 1 0 0 1 1 1 0 FAT domain Kinesin PF00225.18 KOO48648.1 - 1.5e-63 214.5 0.0 3e-63 213.5 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Sigma54_activat PF00158.21 KOO48648.1 - 0.003 17.0 0.3 0.2 11.1 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain TMPIT PF07851.8 KOO48648.1 - 2.1 7.3 8.5 16 4.3 3.3 2.3 2 0 0 2 2 2 0 TMPIT-like protein AAA_22 PF13401.1 KOO48648.1 - 4.6 7.3 5.2 2.1 8.5 0.0 3.0 4 0 0 4 4 4 0 AAA domain PDEase_I PF00233.14 KOO48649.1 - 1.2e-60 205.2 0.0 1.8e-60 204.6 0.0 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase LRR_6 PF13516.1 KOO48649.1 - 5e-32 106.3 0.0 0.00025 20.7 0.0 5.9 5 1 0 5 5 5 5 Leucine Rich repeat z-alpha PF02295.12 KOO48649.1 - 4.4e-05 23.1 2.9 0.0023 17.6 0.0 4.0 4 1 2 6 6 6 1 Adenosine deaminase z-alpha domain LRR_4 PF12799.2 KOO48649.1 - 0.00084 18.9 0.6 0.35 10.5 0.0 3.5 2 1 4 6 6 6 3 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO48649.1 - 0.0075 16.2 2.2 1.7e+02 3.1 0.2 5.6 5 1 1 6 6 6 0 Leucine rich repeat LRR_1 PF00560.28 KOO48649.1 - 0.016 15.1 0.0 51 4.4 0.0 4.8 5 0 0 5 5 5 0 Leucine Rich Repeat CbiG_N PF11760.3 KOO48649.1 - 8.3 6.1 11.2 12 5.6 0.2 4.1 4 1 1 5 5 5 0 Cobalamin synthesis G N-terminal Pkinase PF00069.20 KOO50193.1 - 1.3e-42 145.8 0.0 2.2e-42 145.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO50193.1 - 4.6e-38 130.7 0.0 1.2e-37 129.4 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Adeno_E3_CR2 PF02439.10 KOO50193.1 - 0.00017 21.0 3.6 0.0003 20.2 2.5 1.4 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 Protocadherin PF08374.6 KOO50193.1 - 0.00055 19.6 0.2 0.0012 18.5 0.2 1.5 1 0 0 1 1 1 1 Protocadherin EphA2_TM PF14575.1 KOO50193.1 - 0.039 14.3 0.4 0.087 13.2 0.2 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Glycophorin_A PF01102.13 KOO50193.1 - 0.054 13.2 10.8 0.016 14.9 4.2 2.3 1 1 1 2 2 2 0 Glycophorin A CRC_subunit PF08624.5 KOO50193.1 - 0.14 12.0 0.0 0.59 10.0 0.0 1.9 2 0 0 2 2 2 0 Chromatin remodelling complex Rsc7/Swp82 subunit Shisa PF13908.1 KOO50193.1 - 0.17 12.0 0.2 0.38 10.9 0.2 1.5 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator SKG6 PF08693.5 KOO50193.1 - 0.49 9.7 5.2 1.2 8.5 3.6 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Rifin_STEVOR PF02009.11 KOO50193.1 - 2.8 7.5 14.2 0.024 14.2 1.9 2.7 3 0 0 3 3 3 0 Rifin/stevor family CorA PF01544.13 KOO50195.1 - 2.1e-20 72.9 0.0 2.8e-20 72.5 0.0 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF4092 PF13322.1 KOO50195.1 - 0.13 12.0 0.2 0.43 10.3 0.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4092) Cas1_AcylT PF07779.7 KOO50196.1 - 1.3e-76 258.0 23.1 2.8e-76 256.9 16.1 1.3 1 1 0 1 1 1 1 10 TM Acyl Transferase domain found in Cas1p BNIP3 PF06553.7 KOO50197.1 - 0.19 11.0 1.3 0.28 10.5 0.9 1.2 1 0 0 1 1 1 0 BNIP3 Peptidase_M30 PF10460.4 KOO50197.1 - 0.27 10.0 2.2 0.36 9.6 1.5 1.1 1 0 0 1 1 1 0 Peptidase M30 FdhE PF04216.7 KOO50197.1 - 0.91 9.1 6.7 1.3 8.7 4.6 1.2 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation Arm PF00514.18 KOO50198.1 - 0.013 15.2 0.2 0.013 15.2 0.2 2.6 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Herpes_HEPA PF03324.9 KOO50199.1 - 2.7 8.0 10.4 19 5.3 0.0 5.0 1 1 4 6 6 6 0 Herpesvirus DNA helicase/primase complex associated protein MFS_1 PF07690.11 KOO50201.1 - 5.4e-12 45.1 15.4 7e-12 44.7 10.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily ATG22 PF11700.3 KOO50201.1 - 0.0005 18.6 8.8 0.00066 18.2 6.1 1.1 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like Ion_trans PF00520.26 KOO50202.1 - 1.5e-140 465.0 51.4 2e-44 151.2 4.1 4.4 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.7 KOO50202.1 - 1.7e-06 26.7 5.6 1.7e-06 26.7 3.9 8.5 7 2 1 9 9 9 7 Polycystin cation channel ketoacyl-synt PF00109.21 KOO50207.1 - 2.2e-50 171.4 7.7 3.4e-50 170.9 5.1 1.5 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 KOO50207.1 - 4.4e-23 81.3 4.0 9.7e-23 80.2 2.8 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.20 KOO50207.1 - 1.2e-12 47.8 0.1 2.4e-12 46.9 0.1 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site NAD_binding_7 PF13241.1 KOO50207.1 - 0.11 12.8 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding DUF221 PF02714.10 KOO50210.1 - 8.1e-36 123.5 3.4 8.1e-36 123.5 2.4 1.4 2 0 0 2 2 2 1 Domain of unknown function DUF221 Chorein_N PF12624.2 KOO52729.1 - 3e-26 91.2 0.0 5.8e-26 90.3 0.0 1.5 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter DUF1162 PF06650.7 KOO52730.1 - 6.3e-13 48.5 0.0 1.1e-12 47.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1162) Ank_2 PF12796.2 KOO52730.1 - 9.7e-10 38.6 0.1 2.4e-09 37.3 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 KOO52730.1 - 3.8e-08 32.8 0.1 0.011 15.8 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 KOO52730.1 - 5.5e-08 33.1 0.4 8.8e-06 26.0 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO52730.1 - 1.4e-07 30.9 0.5 0.0053 16.5 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 KOO52730.1 - 3e-06 27.2 0.2 0.0011 19.1 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) PH PF00169.24 KOO52730.1 - 4.7e-06 26.7 0.0 9.9e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 PH domain GRAM PF02893.15 KOO52730.1 - 0.003 17.0 0.0 1.2 8.7 0.0 2.6 2 0 0 2 2 2 2 GRAM domain PH_6 PF15406.1 KOO52730.1 - 0.032 14.2 0.2 0.29 11.2 0.0 2.7 3 0 0 3 3 3 0 Pleckstrin homology domain PH_4 PF15404.1 KOO52730.1 - 0.25 10.8 0.0 0.46 10.0 0.0 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain Pkinase PF00069.20 KOO52731.1 - 3.3e-38 131.3 0.0 4.6e-38 130.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO52731.1 - 9.7e-23 80.5 0.0 1.3e-22 80.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase ACT_4 PF13291.1 KOO52731.1 - 2.9e-05 24.3 0.0 7.2e-05 23.0 0.0 1.7 2 0 0 2 2 2 1 ACT domain DUF2205 PF10224.4 KOO52731.1 - 0.0052 16.3 0.5 0.011 15.2 0.3 1.5 1 0 0 1 1 1 1 Predicted coiled-coil protein (DUF2205) Kinase-like PF14531.1 KOO52731.1 - 0.071 12.0 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like 3HCDH_N PF02737.13 KOO52732.1 - 3.2e-57 193.1 0.3 5.8e-57 192.2 0.2 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH PF00378.15 KOO52732.1 - 3.2e-46 157.4 2.5 6.6e-46 156.4 1.7 1.6 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family 3HCDH PF00725.17 KOO52732.1 - 1.8e-31 108.3 0.1 6.1e-26 90.6 0.1 2.7 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ApbA PF02558.11 KOO52732.1 - 0.00035 20.0 0.1 0.00066 19.1 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA DAO PF01266.19 KOO52732.1 - 0.00041 19.3 0.2 0.00073 18.5 0.2 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_2 PF03446.10 KOO52732.1 - 0.00091 19.0 0.9 0.0032 17.3 0.6 2.0 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_N PF03721.9 KOO52732.1 - 0.001 18.4 0.2 0.002 17.5 0.1 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox PF00070.22 KOO52732.1 - 0.0099 16.2 0.5 0.033 14.6 0.4 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.16 KOO52732.1 - 0.017 14.7 0.7 0.032 13.7 0.5 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.13 KOO52732.1 - 0.017 15.0 0.2 0.059 13.3 0.1 2.1 1 1 0 1 1 1 0 TrkA-N domain NAD_Gly3P_dh_N PF01210.18 KOO52732.1 - 0.018 14.8 0.2 0.034 13.8 0.1 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Shikimate_DH PF01488.15 KOO52732.1 - 0.023 14.7 0.3 0.056 13.5 0.2 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.12 KOO52732.1 - 0.025 14.9 3.6 0.067 13.6 1.2 2.8 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Pyr_redox_2 PF07992.9 KOO52732.1 - 0.039 13.8 0.2 0.083 12.7 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TPR_11 PF13414.1 KOO52733.1 - 2.1e-22 78.5 20.8 2.6e-07 30.1 1.0 6.7 3 2 3 6 6 6 4 TPR repeat TPR_17 PF13431.1 KOO52733.1 - 3.7e-19 67.2 0.9 0.027 14.6 0.0 7.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_16 PF13432.1 KOO52733.1 - 4.5e-14 52.6 33.5 0.0012 19.4 0.1 6.9 4 2 3 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.12 KOO52733.1 - 6e-14 50.7 24.2 0.00021 20.9 0.1 8.9 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOO52733.1 - 6.1e-12 45.3 17.1 2.1e-05 24.3 0.8 5.9 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.1 KOO52733.1 - 9.1e-11 41.4 36.1 0.026 15.1 0.2 9.0 6 3 4 10 10 9 4 Tetratricopeptide repeat TPR_8 PF13181.1 KOO52733.1 - 4.7e-08 32.2 1.2 0.15 11.9 0.0 5.0 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO52733.1 - 2.5e-06 26.8 21.0 1.1 8.9 0.1 9.0 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOO52733.1 - 4e-06 27.0 19.9 0.0015 18.7 0.1 6.6 5 2 0 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO52733.1 - 0.00063 19.5 0.4 0.00063 19.5 0.3 5.7 5 2 2 7 7 7 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO52733.1 - 0.037 13.8 16.7 3.9 7.5 0.0 6.9 6 1 0 6 6 6 0 Tetratricopeptide repeat PilO PF04350.8 KOO52733.1 - 0.065 13.1 0.1 0.2 11.5 0.0 1.8 1 0 0 1 1 1 0 Pilus assembly protein, PilO ketoacyl-synt PF00109.21 KOO52734.1 - 9.7e-34 116.9 1.0 1.2e-33 116.7 0.7 1.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 KOO52734.1 - 0.00065 19.5 0.1 0.049 13.4 0.0 2.8 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 KOO52734.1 - 0.054 12.4 0.1 0.087 11.7 0.0 1.3 1 0 0 1 1 1 0 Thiolase, N-terminal domain DNA_gyraseB PF00204.20 KOO52735.1 - 8.4e-47 158.5 0.0 7.6e-46 155.4 0.0 2.0 2 0 0 2 2 2 1 DNA gyrase B Toprim PF01751.17 KOO52735.1 - 2.6e-25 88.3 0.0 5e-25 87.3 0.0 1.5 1 0 0 1 1 1 1 Toprim domain DNA_gyraseB_C PF00986.16 KOO52735.1 - 1.3e-24 85.7 0.2 2.4e-24 84.8 0.2 1.5 1 0 0 1 1 1 1 DNA gyrase B subunit, carboxyl terminus Toprim_4 PF13662.1 KOO52735.1 - 0.17 11.8 1.4 0.44 10.5 0.2 2.4 2 1 0 2 2 2 0 Toprim domain Tubulin PF00091.20 KOO52736.1 - 7.3e-68 228.6 0.0 8.9e-68 228.3 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 KOO52736.1 - 0.00012 22.1 0.1 0.00019 21.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.1 KOO52736.1 - 0.011 15.2 0.0 0.017 14.6 0.0 1.3 1 0 0 1 1 1 0 Tubulin domain RAP PF08373.5 KOO52737.1 - 6e-06 25.9 0.0 1.3e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 RAP domain FAST_1 PF06743.10 KOO52737.1 - 1.8e-05 24.3 11.0 0.12 12.1 0.0 6.8 5 1 1 6 6 6 3 FAST kinase-like protein, subdomain 1 SUI1 PF01253.17 KOO52738.1 - 7.3e-27 93.0 1.3 7.3e-27 93.0 0.9 1.4 2 0 0 2 2 2 1 Translation initiation factor SUI1 Spectrin PF00435.16 KOO52739.1 - 8.5e-10 38.8 3.7 0.0005 20.3 0.7 3.6 3 0 0 3 3 3 2 Spectrin repeat EF-hand_1 PF00036.27 KOO52739.1 - 2.8e-05 23.0 0.6 0.0051 16.0 0.1 2.9 2 0 0 2 2 2 2 EF hand EFhand_Ca_insen PF08726.5 KOO52739.1 - 0.00028 20.8 2.7 0.0007 19.5 0.0 2.9 4 0 0 4 4 4 1 Ca2+ insensitive EF hand EF-hand_6 PF13405.1 KOO52739.1 - 0.0081 15.9 6.2 0.0082 15.9 0.2 3.7 4 0 0 4 4 4 1 EF-hand domain EF-hand_8 PF13833.1 KOO52739.1 - 0.025 14.1 0.5 2 8.1 0.0 3.1 3 0 0 3 3 3 0 EF-hand domain pair EF-hand_7 PF13499.1 KOO52739.1 - 0.041 14.0 2.8 0.34 11.0 1.5 2.6 1 1 2 3 3 3 0 EF-hand domain pair Ribosom_S12_S23 PF00164.20 KOO52741.1 - 1.1e-39 134.6 0.3 1.3e-39 134.4 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 TPR_11 PF13414.1 KOO52742.1 - 3.5e-22 77.8 10.0 3e-16 58.8 3.3 2.7 2 0 0 2 2 2 2 TPR repeat Flavoprotein PF02441.14 KOO52742.1 - 1.8e-17 63.1 0.4 6.4e-17 61.4 0.0 2.0 2 0 0 2 2 2 1 Flavoprotein TPR_2 PF07719.12 KOO52742.1 - 1.6e-15 55.6 6.9 3.4e-06 26.5 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO52742.1 - 6.3e-15 54.0 6.2 3.6e-06 26.3 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO52742.1 - 2.2e-07 30.1 1.6 0.018 14.7 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO52742.1 - 6.3e-07 29.4 3.8 0.015 15.8 0.0 3.7 1 1 3 4 4 4 2 Tetratricopeptide repeat UPF0121 PF03661.8 KOO52742.1 - 7.2e-07 28.6 5.6 7.2e-07 28.6 3.9 1.7 2 1 0 2 2 2 1 Uncharacterised protein family (UPF0121) TPR_16 PF13432.1 KOO52742.1 - 1.9e-05 25.2 11.4 0.036 14.7 2.2 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO52742.1 - 0.00014 21.7 4.3 0.083 13.1 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO52742.1 - 0.00099 18.7 0.1 1 9.3 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO52742.1 - 0.0022 18.3 0.5 0.088 13.1 0.0 2.7 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOO52742.1 - 0.0047 16.8 7.1 0.58 10.1 0.9 3.3 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.1 KOO52742.1 - 0.03 14.7 0.6 6.3 7.4 0.1 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat MscS_porin PF12795.2 KOO52744.1 - 0.0019 17.5 26.5 0.087 12.1 2.9 3.0 1 1 2 3 3 3 2 Mechanosensitive ion channel porin domain Myb_CC_LHEQLE PF14379.1 KOO52744.1 - 0.075 12.6 0.1 0.79 9.3 0.0 2.4 2 0 0 2 2 2 0 MYB-CC type transfactor, LHEQLE motif DUF3584 PF12128.3 KOO52744.1 - 0.31 8.3 11.4 0.39 7.9 7.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4423 PF14394.1 KOO52744.1 - 0.34 10.4 3.4 0.4 10.1 0.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4423) HlyD PF00529.15 KOO52744.1 - 3.8 6.7 29.8 4.7 6.4 20.6 1.1 1 0 0 1 1 1 0 HlyD family secretion protein MxiH PF09392.5 KOO52744.1 - 5 7.7 15.3 8.6e+02 0.6 10.6 3.2 1 1 0 1 1 1 0 Type III secretion needle MxiH like Baculo_PEP_C PF04513.7 KOO52744.1 - 9.9 5.9 8.2 28 4.5 2.4 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus SHIPPO-rpt PF07004.7 KOO52745.1 - 2.2e-08 34.6 16.0 0.004 17.9 0.2 4.3 4 1 0 4 4 4 3 Sperm-tail PG-rich repeat Rick_17kDa_Anti PF05433.10 KOO52745.1 - 0.17 11.5 9.0 0.41 10.3 6.2 1.6 1 0 0 1 1 1 0 Glycine zipper 2TM domain Bacteriocin_IIc PF10439.4 KOO52745.1 - 0.35 11.0 2.4 0.78 9.9 1.7 1.5 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Gly-zipper_Omp PF13488.1 KOO52745.1 - 0.97 9.1 8.6 0.3 10.7 3.8 1.7 2 0 0 2 2 2 0 Glycine zipper Nucleotid_trans PF03407.11 KOO52746.1 - 1.2e-33 116.7 0.0 1.6e-32 113.0 0.0 2.3 2 1 0 2 2 2 1 Nucleotide-diphospho-sugar transferase HMG_box_2 PF09011.5 KOO52746.1 - 2.6e-06 27.6 0.1 6.7e-06 26.3 0.1 1.7 1 0 0 1 1 1 1 HMG-box domain Histone PF00125.19 KOO52746.1 - 0.00023 21.2 0.1 0.00053 20.0 0.0 1.6 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 KOO52746.1 - 0.00042 20.3 0.0 0.00094 19.1 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone HMG_box PF00505.14 KOO52746.1 - 0.00069 19.8 0.1 0.0016 18.6 0.1 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box BBIP10 PF14777.1 KOO52748.1 - 3.7e-19 67.8 0.1 3.9e-19 67.7 0.1 1.1 1 0 0 1 1 1 1 Cilia BBSome complex subunit 10 Ran_BP1 PF00638.13 KOO52749.1 - 0.00073 19.5 0.0 0.0013 18.8 0.0 1.3 1 0 0 1 1 1 1 RanBP1 domain DUF3275 PF11679.3 KOO52749.1 - 3.2 7.3 8.3 0.8 9.2 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3275) Neisseria_TspB PF05616.8 KOO52749.1 - 7.1 4.8 7.5 13 4.0 5.2 1.3 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein PCIF1_WW PF12237.3 KOO52750.1 - 3.2e-42 143.8 0.1 1.4e-41 141.6 0.0 1.9 2 0 0 2 2 2 1 Phosphorylated CTD interacting factor 1 WW domain HECT PF00632.20 KOO52751.1 - 1.2e-61 208.5 0.0 2.1e-61 207.8 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.21 KOO52751.1 - 3.5e-09 36.3 0.1 7.4e-09 35.3 0.1 1.6 1 0 0 1 1 1 1 WW domain IFT57 PF10498.4 KOO52751.1 - 5.7 5.5 2.2 8.8 4.9 1.5 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Glyco_transf_90 PF05686.7 KOO52752.1 - 6.4e-38 130.4 0.0 1.6e-37 129.1 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.1 KOO52752.1 - 0.0053 16.9 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 ABC_tran PF00005.22 KOO52753.1 - 1.7e-21 76.9 0.0 2.4e-21 76.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.19 KOO52753.1 - 3.3e-14 52.5 23.3 6.5e-13 48.3 11.3 2.8 2 1 1 3 3 3 2 ABC-2 type transporter AAA_21 PF13304.1 KOO52753.1 - 2.6e-09 37.4 0.0 0.00019 21.4 0.0 2.2 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.14 KOO52753.1 - 0.00019 20.7 0.3 0.015 14.5 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 KOO52753.1 - 0.0023 17.0 0.0 0.47 9.4 0.0 2.1 2 0 0 2 2 2 2 AAA ATPase domain AAA PF00004.24 KOO52753.1 - 0.0051 17.0 0.2 0.022 14.9 0.2 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.11 KOO52753.1 - 0.0079 15.3 0.1 0.012 14.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 KOO52753.1 - 0.0079 16.3 0.3 0.02 15.0 0.2 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOO52753.1 - 0.025 14.5 0.0 0.045 13.7 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain ABC2_membrane_3 PF12698.2 KOO52753.1 - 0.036 13.0 20.8 0.049 12.6 14.0 1.5 1 1 0 1 1 1 0 ABC-2 family transporter protein AAA_33 PF13671.1 KOO52753.1 - 0.057 13.3 0.2 0.1 12.5 0.1 1.5 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.4 KOO52753.1 - 0.09 12.2 0.2 0.18 11.3 0.1 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.1 KOO52753.1 - 0.11 12.0 0.1 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.1 KOO52753.1 - 0.14 12.1 0.6 0.25 11.3 0.4 1.4 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 KOO52753.1 - 0.18 11.4 0.1 0.28 10.8 0.1 1.2 1 0 0 1 1 1 0 Archaeal ATPase Abhydrolase_6 PF12697.2 KOO52754.1 - 1.1e-36 126.8 1.1 2.3e-36 125.7 0.8 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO52754.1 - 2.6e-19 69.6 0.0 2.7e-18 66.3 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 KOO52754.1 - 4.7e-11 42.6 0.0 1.3e-10 41.2 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 KOO52754.1 - 0.00038 20.2 0.1 0.00093 19.0 0.1 1.6 1 0 0 1 1 1 1 Putative lysophospholipase Glyco_hydro_30 PF02055.11 KOO52755.1 - 4.2e-23 81.3 0.0 9.4e-12 43.8 0.0 2.2 2 0 0 2 2 2 2 O-Glycosyl hydrolase family 30 Glyco_hydro_cc PF11790.3 KOO52755.1 - 0.0016 17.9 0.0 0.0023 17.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core p450 PF00067.17 KOO52757.1 - 4.3e-66 223.3 0.0 6.7e-66 222.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 NIF PF03031.13 KOO52758.1 - 0.02 14.5 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 NLI interacting factor-like phosphatase SURNod19 PF07712.7 KOO52760.1 - 0.039 12.4 0.0 1.1 7.6 0.0 2.2 2 0 0 2 2 2 0 Stress up-regulated Nod 19 LRR_6 PF13516.1 KOO52762.1 - 9.2e-09 34.4 2.5 0.63 10.2 0.0 4.8 4 0 0 4 4 4 4 Leucine Rich repeat TSC22 PF01166.13 KOO52763.1 - 9.3e-05 22.3 1.8 0.0012 18.7 0.2 2.4 2 0 0 2 2 2 1 TSC-22/dip/bun family HEAT PF02985.17 KOO52763.1 - 0.12 12.5 1.4 4.5 7.6 0.1 3.0 3 0 0 3 3 3 0 HEAT repeat DUF972 PF06156.8 KOO52763.1 - 0.42 10.9 10.2 0.09 13.1 2.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Atg14 PF10186.4 KOO52763.1 - 0.64 8.9 5.8 0.97 8.3 4.0 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 DUF724 PF05266.9 KOO52763.1 - 1.2 8.7 10.8 1.9 8.0 7.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TATR PF03430.8 KOO52763.1 - 9.8 4.6 8.3 12 4.3 5.8 1.1 1 0 0 1 1 1 0 Trans-activating transcriptional regulator Arm PF00514.18 KOO52765.1 - 4.6e-43 143.6 12.7 3.1e-08 33.1 0.1 6.1 6 0 0 6 6 6 6 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 KOO52765.1 - 0.0012 19.2 14.0 2.4 8.7 0.3 4.5 1 1 4 5 5 5 5 HEAT-like repeat RPAP1_C PF08620.5 KOO52765.1 - 0.0014 18.4 0.0 66 3.4 0.0 4.9 5 1 0 5 5 5 0 RPAP1-like, C-terminal Acyl-CoA_dh_N PF02771.11 KOO52765.1 - 0.0041 17.6 6.7 2.9 8.5 0.3 4.2 1 1 2 4 4 4 2 Acyl-CoA dehydrogenase, N-terminal domain Arm_2 PF04826.8 KOO52765.1 - 0.0094 15.0 0.0 2 7.4 0.0 2.6 1 1 2 3 3 3 2 Armadillo-like SPOR PF05036.8 KOO52765.1 - 0.12 12.5 2.9 12 6.1 0.0 4.2 4 1 0 4 4 4 0 Sporulation related domain TPR_6 PF13174.1 KOO52765.1 - 0.55 10.8 8.4 30 5.3 0.1 4.4 5 1 1 6 6 6 0 Tetratricopeptide repeat HEAT_2 PF13646.1 KOO52765.1 - 0.92 9.8 18.4 9.5 6.5 3.2 3.0 1 1 1 2 2 2 0 HEAT repeats SpoVA PF03862.8 KOO52765.1 - 5 7.2 7.5 6.9 6.8 0.0 3.5 2 2 1 4 4 4 0 SpoVA protein CH PF00307.26 KOO52766.1 - 3e-68 226.7 2.8 4.7e-19 68.4 0.0 4.3 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_1 PF00036.27 KOO52766.1 - 5.2e-13 47.2 0.4 3.2e-05 22.9 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO52766.1 - 8.3e-12 45.0 0.0 3.7e-11 43.0 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO52766.1 - 2.5e-10 39.7 0.1 1.5e-08 34.0 0.0 2.9 2 1 1 3 3 3 2 EF-hand domain pair CAMSAP_CH PF11971.3 KOO52766.1 - 3.1e-10 39.5 0.0 0.0016 18.0 0.0 3.5 3 0 0 3 3 3 2 CAMSAP CH domain EF-hand_6 PF13405.1 KOO52766.1 - 1.2e-09 37.1 0.0 9.2e-05 22.0 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.1 KOO52766.1 - 5.8e-09 34.8 0.1 0.00035 19.7 0.0 2.8 2 0 0 2 2 2 2 EF hand Pkinase PF00069.20 KOO52767.1 - 5.6e-34 117.4 0.0 7.8e-34 116.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO52767.1 - 2e-30 105.7 0.0 2.8e-30 105.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase TIR_2 PF13676.1 KOO52767.1 - 9.1e-05 22.5 0.0 0.00019 21.5 0.0 1.5 1 0 0 1 1 1 1 TIR domain Kinase-like PF14531.1 KOO52767.1 - 0.00096 18.1 0.0 0.0016 17.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO52767.1 - 0.022 14.4 1.9 0.18 11.4 0.6 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family PUB PF09409.5 KOO52768.1 - 7e-29 99.4 0.0 1.6e-16 59.8 0.0 2.2 2 0 0 2 2 2 2 PUB domain YfbU PF03887.9 KOO52768.1 - 0.022 14.3 0.0 5.8 6.4 0.0 2.1 1 1 0 2 2 2 0 YfbU domain UBX PF00789.15 KOO52768.1 - 0.068 13.2 0.0 0.91 9.6 0.0 2.7 3 1 1 4 4 4 0 UBX domain AIG2_2 PF13772.1 KOO52771.1 - 0.08 13.0 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 AIG2-like family DUF347 PF03988.7 KOO52772.1 - 1.6 8.6 11.5 2.4 8.1 0.4 3.6 4 0 0 4 4 4 0 Repeat of Unknown Function (DUF347) EF-hand_1 PF00036.27 KOO52773.1 - 4.1e-12 44.4 0.0 2.6e-05 23.1 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO52773.1 - 3.7e-11 42.9 0.1 6.6e-11 42.1 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO52773.1 - 7e-10 37.9 0.3 4.1e-05 23.0 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO52773.1 - 6.2e-09 35.3 0.1 0.0026 17.3 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO52773.1 - 4.6e-07 28.8 0.2 0.00022 20.4 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.2 KOO52773.1 - 0.0069 16.1 0.1 0.34 10.6 0.0 2.2 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand ChaB PF06150.7 KOO52773.1 - 0.013 15.2 0.2 0.44 10.3 0.1 2.6 2 0 0 2 2 2 0 ChaB Ank_2 PF12796.2 KOO52774.1 - 2.1e-47 159.3 0.9 1.4e-09 38.1 0.2 8.0 5 1 2 7 7 7 5 Ankyrin repeats (3 copies) Ank PF00023.25 KOO52774.1 - 3.6e-32 108.5 18.1 0.00012 21.6 0.0 12.9 14 0 0 14 14 13 7 Ankyrin repeat UCH PF00443.24 KOO52774.1 - 4.6e-23 81.7 0.0 7.5e-23 80.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ank_3 PF13606.1 KOO52774.1 - 3.5e-19 66.9 6.6 0.015 15.5 0.0 11.2 11 0 0 11 11 11 4 Ankyrin repeat Ank_4 PF13637.1 KOO52774.1 - 1.8e-16 60.1 4.8 0.16 12.5 0.0 9.7 8 3 4 12 12 11 5 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO52774.1 - 4.6e-14 52.1 12.4 0.019 15.1 0.1 9.9 7 3 3 10 10 10 3 Ankyrin repeats (many copies) zf-CCCH PF00642.19 KOO52774.1 - 1.6e-05 24.4 4.3 3.4e-05 23.4 3.0 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) UCH_1 PF13423.1 KOO52774.1 - 3.7e-05 23.3 0.0 7.9e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF3563 PF12086.3 KOO52774.1 - 0.0032 17.1 0.4 0.012 15.2 0.3 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3563) KH_1 PF00013.24 KOO52774.1 - 0.019 14.6 0.0 0.04 13.5 0.0 1.5 1 0 0 1 1 1 0 KH domain KH_3 PF13014.1 KOO52774.1 - 0.16 11.6 0.0 0.41 10.3 0.0 1.7 1 0 0 1 1 1 0 KH domain SAPS PF04499.10 KOO52774.1 - 3.5 6.1 5.8 7.3 5.1 4.0 1.5 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Borrelia_P83 PF05262.6 KOO52774.1 - 6.3 4.9 21.8 10 4.2 15.1 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein IQ PF00612.22 KOO52775.1 - 0.072 12.7 51.5 1.4 8.8 0.5 8.6 8 0 0 8 8 8 0 IQ calmodulin-binding motif GAS PF13851.1 KOO52775.1 - 0.3 10.2 17.3 0.93 8.6 8.9 2.5 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Herpes_UL87 PF03043.9 KOO52775.1 - 1.5 7.1 5.9 26 3.0 4.1 2.2 1 1 0 1 1 1 0 Herpesvirus UL87 family Pro_CA PF00484.14 KOO52776.1 - 1.3e-62 210.3 1.4 9e-37 126.4 0.1 3.4 3 0 0 3 3 3 3 Carbonic anhydrase AIRS_C PF02769.17 KOO52778.1 - 8.5e-19 68.0 0.9 1.6e-18 67.2 0.6 1.4 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.19 KOO52778.1 - 3.4e-14 52.8 1.5 8.1e-14 51.6 0.1 2.3 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain Pyr_redox_2 PF07992.9 KOO52778.1 - 2.4e-06 27.5 0.0 0.0023 17.8 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOO52778.1 - 0.00016 22.0 0.1 0.00016 22.0 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trypsin_2 PF13365.1 KOO52779.1 - 1.2e-11 44.5 0.1 2.3e-11 43.6 0.1 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.21 KOO52779.1 - 7.7e-05 22.3 0.0 0.00017 21.2 0.0 1.5 1 0 0 1 1 1 1 Trypsin Peptidase_S46 PF10459.4 KOO52779.1 - 0.0046 15.4 0.1 0.0069 14.8 0.1 1.1 1 0 0 1 1 1 1 Peptidase S46 PDZ_2 PF13180.1 KOO52779.1 - 0.044 13.6 0.0 0.1 12.5 0.0 1.6 1 0 0 1 1 1 0 PDZ domain DUF4507 PF14964.1 KOO52779.1 - 0.13 10.9 0.0 0.2 10.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4507) RRF PF01765.14 KOO52780.1 - 2.1e-59 199.6 0.3 3e-59 199.1 0.1 1.3 1 1 0 1 1 1 1 Ribosome recycling factor DUF2937 PF11157.3 KOO52780.1 - 0.13 11.5 0.2 0.24 10.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) DUF883 PF05957.8 KOO52780.1 - 0.22 11.9 4.7 0.14 12.5 1.7 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) UCH PF00443.24 KOO52781.1 - 3.3e-23 82.1 0.0 4.1e-23 81.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 KOO52781.1 - 6.1e-12 45.5 0.0 8.4e-12 45.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UAA PF08449.6 KOO52782.1 - 4.9e-50 170.1 1.6 6.2e-50 169.8 1.1 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 KOO52782.1 - 2e-08 34.3 16.3 5.3e-06 26.4 3.8 2.3 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.11 KOO52782.1 - 9.8e-07 28.5 5.7 9.8e-07 28.5 3.9 2.4 2 1 0 2 2 2 1 Triose-phosphate Transporter family DUF1195 PF06708.6 KOO52782.1 - 0.018 14.4 0.2 0.032 13.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1195) DUF914 PF06027.7 KOO52782.1 - 0.081 11.7 0.1 0.1 11.4 0.1 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF914) Fer4 PF00037.22 KOO52783.1 - 2.4e-14 52.2 16.4 1.3e-08 34.0 2.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.2 KOO52783.1 - 3.9e-12 46.3 10.6 5.8e-12 45.8 7.4 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.1 KOO52783.1 - 6.7e-10 39.5 17.1 7.8e-07 29.7 7.1 2.2 1 1 1 2 2 2 2 4Fe-4S double cluster binding domain Fer4_10 PF13237.1 KOO52783.1 - 8.9e-10 38.2 10.3 1.7e-09 37.3 7.1 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.1 KOO52783.1 - 1.4e-08 34.8 11.1 3.5e-08 33.5 7.9 1.6 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.2 KOO52783.1 - 2.5e-08 33.3 14.4 0.00013 21.7 1.7 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_21 PF14697.1 KOO52783.1 - 3e-08 33.3 22.5 8e-06 25.6 8.4 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.2 KOO52783.1 - 6e-08 32.2 17.7 0.00064 19.4 3.2 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.1 KOO52783.1 - 1.4e-07 31.4 19.2 6.9e-06 25.9 7.2 1.9 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_4 PF12800.2 KOO52783.1 - 2e-06 27.6 11.6 0.00056 20.0 2.1 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.1 KOO52783.1 - 5.3e-05 23.4 9.9 0.00077 19.7 7.3 2.1 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_18 PF13746.1 KOO52783.1 - 9.1e-05 22.8 10.1 0.029 14.7 0.8 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.1 KOO52783.1 - 0.00013 22.2 10.7 0.05 13.9 0.2 2.5 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4_15 PF13459.1 KOO52783.1 - 0.0021 18.5 12.4 0.23 12.0 1.0 2.6 2 1 0 2 2 2 2 4Fe-4S single cluster domain Fer4_3 PF12798.2 KOO52783.1 - 0.0032 17.8 17.5 0.0071 16.8 2.8 2.3 2 0 0 2 2 2 1 4Fe-4S binding domain c-SKI_SMAD_bind PF08782.5 KOO52783.1 - 0.22 11.6 4.5 0.47 10.6 0.1 2.3 1 1 1 2 2 2 0 c-SKI Smad4 binding domain EF-hand_1 PF00036.27 KOO52784.1 - 1.8e-11 42.4 0.0 0.00018 20.5 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO52784.1 - 3.5e-10 38.8 0.0 0.00034 20.2 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO52784.1 - 2e-07 31.0 0.0 1.6e-05 24.9 0.0 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO52784.1 - 7.6e-07 28.1 0.0 0.0047 16.2 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO52784.1 - 0.004 16.7 0.0 0.013 15.0 0.0 1.9 1 1 1 2 2 2 1 EF-hand domain pair LEAP-2 PF07359.6 KOO52784.1 - 0.12 12.0 0.1 0.3 10.7 0.0 1.7 2 0 0 2 2 2 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) Pkinase PF00069.20 KOO52786.1 - 2.2e-57 194.1 0.2 3.6e-57 193.4 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO52786.1 - 2e-42 145.0 0.1 2.9e-42 144.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 KOO52786.1 - 0.037 13.1 0.1 0.071 12.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sugar_tr PF00083.19 KOO52787.1 - 2.4e-13 49.5 17.8 3.3e-11 42.4 9.4 3.0 3 0 0 3 3 3 3 Sugar (and other) transporter MFS_1 PF07690.11 KOO52787.1 - 3e-06 26.1 17.1 0.00099 17.9 6.7 2.9 2 1 1 3 3 3 2 Major Facilitator Superfamily SHIPPO-rpt PF07004.7 KOO52789.1 - 2.5e-12 47.0 25.1 0.87 10.6 0.1 9.6 9 0 0 9 9 9 6 Sperm-tail PG-rich repeat ECR1_N PF14382.1 KOO52789.1 - 0.38 10.0 10.7 42 3.5 0.0 5.7 6 0 0 6 6 6 0 Exosome complex exonuclease RRP4 N-terminal region WW PF00397.21 KOO52791.1 - 6.9e-09 35.4 4.5 1.4e-08 34.4 3.1 1.5 1 0 0 1 1 1 1 WW domain Fer4_15 PF13459.1 KOO52791.1 - 0.00021 21.7 0.1 0.00087 19.8 0.0 2.1 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_13 PF13370.1 KOO52791.1 - 0.0022 18.3 0.1 0.0095 16.2 0.0 2.2 1 0 0 1 1 1 1 4Fe-4S single cluster domain Med9 PF07544.8 KOO52791.1 - 0.076 12.7 0.1 0.19 11.4 0.1 1.7 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 MbtH PF03621.8 KOO52791.1 - 0.11 11.8 0.9 0.4 10.0 0.1 2.2 2 0 0 2 2 2 0 MbtH-like protein MtrC PF04211.8 KOO52792.1 - 0.0084 15.1 6.5 0.013 14.5 4.5 1.3 1 0 0 1 1 1 1 Tetrahydromethanopterin S-methyltransferase, subunit C PHO4 PF01384.15 KOO52792.1 - 0.02 13.5 3.4 0.023 13.3 2.4 1.2 1 0 0 1 1 1 0 Phosphate transporter family IncA PF04156.9 KOO52792.1 - 0.033 13.7 4.0 0.035 13.7 2.8 1.1 1 0 0 1 1 1 0 IncA protein Polysacc_synt PF01943.12 KOO52792.1 - 0.13 11.4 4.5 0.13 11.5 3.1 1.0 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein PTS_EIIC PF02378.13 KOO52792.1 - 0.15 10.8 3.8 0.14 10.9 2.6 1.0 1 0 0 1 1 1 0 Phosphotransferase system, EIIC DUF21 PF01595.15 KOO52792.1 - 0.25 10.6 5.8 0.29 10.4 4.0 1.1 1 0 0 1 1 1 0 Domain of unknown function DUF21 YesK PF14150.1 KOO52792.1 - 0.4 10.8 8.6 0.32 11.1 1.0 2.4 1 1 1 2 2 2 0 YesK-like protein DUF2953 PF11167.3 KOO52792.1 - 2 8.3 9.0 1.3e+02 2.5 6.2 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2953) Clostridium_P47 PF06597.6 KOO52792.1 - 2.6 6.4 7.3 2.5 6.5 5.0 1.0 1 0 0 1 1 1 0 Clostridium P-47 protein Colicin PF01024.14 KOO52792.1 - 6.3 6.3 9.3 7.5 6.0 6.5 1.1 1 0 0 1 1 1 0 Colicin pore forming domain FKBP_C PF00254.23 KOO52793.1 - 1.4e-06 28.1 0.0 3.9e-06 26.7 0.0 1.7 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase LRR_8 PF13855.1 KOO52794.1 - 2.4e-05 24.0 0.1 5.6e-05 22.8 0.1 1.6 1 0 0 1 1 1 1 Leucine rich repeat LRR_1 PF00560.28 KOO52794.1 - 0.002 17.9 0.3 0.02 14.8 0.0 2.8 3 0 0 3 3 3 1 Leucine Rich Repeat LRR_6 PF13516.1 KOO52794.1 - 0.0021 17.9 0.0 0.1 12.7 0.0 3.3 3 0 0 3 3 3 1 Leucine Rich repeat LRR_4 PF12799.2 KOO52794.1 - 0.0038 16.8 0.0 0.011 15.3 0.0 1.8 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO52794.1 - 0.035 14.2 0.4 1.9 9.0 0.0 3.6 3 0 0 3 3 3 0 Leucine rich repeat Dpy-30 PF05186.8 KOO52796.1 - 0.041 13.3 0.1 0.22 11.0 0.0 2.2 3 0 0 3 3 3 0 Dpy-30 motif EF-hand_1 PF00036.27 KOO52798.1 - 1.5e-19 67.7 0.0 0.00088 18.4 0.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO52798.1 - 5.7e-18 63.1 1.2 0.00094 18.8 0.0 6.1 6 0 0 6 6 6 4 EF-hand domain EF-hand_7 PF13499.1 KOO52798.1 - 1.6e-17 63.3 0.0 4.2e-08 33.2 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO52798.1 - 1.5e-14 52.5 1.9 0.033 13.5 0.0 4.8 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO52798.1 - 1.8e-12 46.6 0.1 3.8e-05 23.1 0.0 5.0 4 1 1 5 5 5 2 EF-hand domain pair Ank_2 PF12796.2 KOO52798.1 - 5.7e-10 39.3 1.1 5.2e-08 33.1 0.7 3.2 2 1 1 3 3 3 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO52798.1 - 0.0001 22.7 0.2 0.02 15.3 0.2 3.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.25 KOO52798.1 - 0.00046 19.8 0.9 0.029 14.1 0.5 3.2 3 0 0 3 3 3 1 Ankyrin repeat EF-hand_10 PF14788.1 KOO52798.1 - 0.0068 16.0 0.0 2.1 8.0 0.0 3.1 3 0 0 3 3 3 1 EF hand EF-hand_4 PF12763.2 KOO52798.1 - 0.059 13.1 0.0 9.7 5.9 0.0 2.6 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand Ank_5 PF13857.1 KOO52798.1 - 0.08 13.2 0.8 1.1 9.5 0.3 2.8 2 1 1 3 3 2 0 Ankyrin repeats (many copies) EF-hand_9 PF14658.1 KOO52798.1 - 0.13 12.1 0.0 1.8 8.5 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain Cep57_MT_bd PF06657.8 KOO52798.1 - 5.1 7.1 5.4 46 4.0 0.1 3.4 4 0 0 4 4 4 0 Centrosome microtubule-binding domain of Cep57 ArfGap PF01412.13 KOO52799.1 - 0.00044 20.0 0.0 0.00092 18.9 0.0 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf SpoVS PF04232.7 KOO52800.1 - 6.5e-39 131.3 5.8 1e-19 69.8 2.1 2.1 2 0 0 2 2 2 2 Stage V sporulation protein S (SpoVS) FumaraseC_C PF10415.4 KOO52800.1 - 0.025 14.6 0.1 6.8 6.8 0.0 2.5 2 0 0 2 2 2 0 Fumarase C C-terminus DUF2188 PF09954.4 KOO52800.1 - 1.5 8.8 0.0 1.5 8.8 0.0 2.6 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2188) Pkinase PF00069.20 KOO52801.1 - 4.7e-33 114.4 0.0 8e-33 113.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PP2C PF00481.16 KOO52801.1 - 1.2e-26 93.7 0.0 1.8e-26 93.0 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C Pkinase_Tyr PF07714.12 KOO52801.1 - 2.2e-24 85.9 0.0 2.8e-24 85.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PP2C_2 PF13672.1 KOO52801.1 - 1.2e-06 28.1 0.1 3.3e-06 26.6 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 KOO52801.1 - 1.3e-05 25.0 0.3 0.00015 21.5 0.2 2.1 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) APH PF01636.18 KOO52801.1 - 0.021 14.5 0.1 0.04 13.6 0.1 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Na_H_Exchanger PF00999.16 KOO52802.1 - 1.6e-46 158.6 25.3 1.9e-46 158.3 17.5 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DUF2613 PF11021.3 KOO52802.1 - 0.14 11.8 1.5 0.49 10.1 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) Rad51 PF08423.6 KOO52803.1 - 8.9e-26 90.3 0.0 2.4e-25 88.9 0.0 1.6 2 0 0 2 2 2 1 Rad51 AAA_25 PF13481.1 KOO52803.1 - 2.9e-11 43.1 0.2 5.3e-11 42.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 KOO52803.1 - 3.7e-08 32.7 0.3 4.8e-07 29.1 0.2 2.2 1 1 0 1 1 1 1 KaiC RecA PF00154.16 KOO52803.1 - 0.00019 20.6 1.6 0.022 13.8 0.2 2.1 2 0 0 2 2 2 2 recA bacterial DNA recombination protein DnaB_C PF03796.10 KOO52803.1 - 0.0002 20.3 0.3 0.078 11.8 0.0 2.1 2 0 0 2 2 2 2 DnaB-like helicase C terminal domain AAA_22 PF13401.1 KOO52803.1 - 0.015 15.4 0.0 0.037 14.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain PhoH PF02562.11 KOO52803.1 - 0.026 13.7 0.1 0.046 12.9 0.1 1.3 1 0 0 1 1 1 0 PhoH-like protein DUF2075 PF09848.4 KOO52803.1 - 0.051 12.5 0.0 0.075 11.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.22 KOO52803.1 - 0.15 12.3 0.0 0.25 11.6 0.0 1.3 1 1 0 1 1 1 0 ABC transporter Reo_sigmaC PF04582.7 KOO52804.1 - 0.00077 18.7 31.3 0.0016 17.6 4.2 5.3 5 1 1 6 6 6 3 Reovirus sigma C capsid protein HlyD PF00529.15 KOO52804.1 - 0.0037 16.6 22.9 0.0037 16.6 15.9 5.7 3 2 2 5 5 5 1 HlyD family secretion protein HC2 PF07382.6 KOO52805.1 - 0.017 14.9 35.7 0.023 14.5 24.8 1.1 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 Asp-B-Hydro_N PF05279.6 KOO52805.1 - 3.2 7.5 11.0 4.3 7.0 7.6 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region TAF4 PF05236.9 KOO52805.1 - 6.1 6.0 17.8 9.7 5.3 12.4 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family TFIIA PF03153.8 KOO52805.1 - 7.7 6.2 8.1 10 5.8 5.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MDMPI_N PF11716.3 KOO52807.1 - 0.29 11.5 5.6 0.086 13.2 1.3 1.9 2 0 0 2 2 2 0 Mycothiol maleylpyruvate isomerase N-terminal domain JAB PF01398.16 KOO52808.1 - 5.7e-13 48.6 0.0 9.2e-13 47.9 0.0 1.2 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 KOO52808.1 - 7.7e-08 31.8 0.5 2.3e-07 30.3 0.1 2.0 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain LRR_6 PF13516.1 KOO52809.1 - 2.9e-19 66.9 1.1 0.00057 19.6 0.0 4.7 4 0 0 4 4 4 4 Leucine Rich repeat Phage_integ_N PF09003.5 KOO52809.1 - 2.7 7.7 5.0 59 3.4 0.1 3.9 4 0 0 4 4 4 0 Bacteriophage lambda integrase, N-terminal domain MFS_1 PF07690.11 KOO52811.1 - 4.3e-19 68.4 7.3 7.4e-19 67.6 5.1 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_3 PF05977.8 KOO52811.1 - 2.6e-05 22.5 0.8 2.6e-05 22.5 0.6 1.5 2 0 0 2 2 2 1 Transmembrane secretion effector Sugar_tr PF00083.19 KOO52811.1 - 0.00065 18.3 5.0 0.036 12.6 4.5 2.2 2 1 0 2 2 2 1 Sugar (and other) transporter DUF791 PF05631.9 KOO52811.1 - 0.0025 16.6 0.1 0.0036 16.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF791) Homeobox PF00046.24 KOO52812.1 - 0.00021 20.8 1.7 0.00051 19.5 1.2 1.7 1 1 0 1 1 1 1 Homeobox domain Ribosomal_S16 PF00886.14 KOO52812.1 - 0.096 12.4 0.5 0.12 12.0 0.0 1.7 2 1 0 2 2 2 0 Ribosomal protein S16 DnaJ PF00226.26 KOO52814.1 - 0.018 14.7 0.1 0.063 13.0 0.0 1.9 2 0 0 2 2 2 0 DnaJ domain INCENP_ARK-bind PF03941.10 KOO52814.1 - 0.062 13.1 0.2 0.19 11.6 0.1 1.8 1 0 0 1 1 1 0 Inner centromere protein, ARK binding region DUF148 PF02520.12 KOO52814.1 - 0.22 11.3 0.2 0.22 11.3 0.1 1.9 3 0 0 3 3 3 0 Domain of unknown function DUF148 Kinesin PF00225.18 KOO52815.1 - 1.1e-41 142.6 0.1 1.6e-41 142.1 0.1 1.2 1 0 0 1 1 1 1 Kinesin motor domain Kinesin PF00225.18 KOO52816.1 - 1.5e-27 96.1 0.0 1.8e-27 95.9 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain T2SE PF00437.15 KOO52816.1 - 0.083 11.7 0.0 0.1 11.5 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein Peptidase_M20 PF01546.23 KOO52818.1 - 1.3e-28 99.8 0.0 2.4e-28 98.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 KOO52818.1 - 2e-11 43.6 0.0 3.6e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 KOO52818.1 - 0.0034 17.1 0.1 0.1 12.3 0.0 2.6 2 0 0 2 2 2 1 Peptidase family M28 GspL_C PF12693.2 KOO52818.1 - 0.019 14.7 1.0 0.048 13.4 0.7 1.6 1 0 0 1 1 1 0 GspL periplasmic domain GTP_EFTU PF00009.22 KOO52819.1 - 6.8e-08 32.1 0.0 1e-07 31.5 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_28 PF13521.1 KOO52819.1 - 0.017 15.0 0.1 0.034 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 KOO52819.1 - 0.021 14.7 0.0 0.037 13.9 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase Miro PF08477.8 KOO52819.1 - 0.03 14.8 0.1 0.068 13.6 0.0 1.7 2 1 0 2 2 2 0 Miro-like protein ABC_tran PF00005.22 KOO52819.1 - 0.051 13.8 0.0 0.074 13.3 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.1 KOO52819.1 - 0.12 11.9 0.0 0.26 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain MRP-S31 PF15433.1 KOO52820.1 - 0.12 11.7 0.3 0.16 11.3 0.2 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 FSH1 PF03959.8 KOO52821.1 - 4.6e-13 49.1 0.1 1.5e-11 44.1 0.0 2.1 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.2 KOO52821.1 - 0.00095 19.1 4.5 0.0036 17.2 3.1 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO52821.1 - 0.0069 16.1 0.1 0.009 15.7 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family cNMP_binding PF00027.24 KOO52822.1 - 8.1e-21 73.6 0.0 2.3e-12 46.5 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain DBP10CT PF08147.7 KOO52822.1 - 0.047 13.5 0.0 0.09 12.6 0.0 1.4 1 0 0 1 1 1 0 DBP10CT (NUC160) domain OxoDH_E1alpha_N PF12573.3 KOO52823.1 - 0.078 12.5 0.3 0.29 10.7 0.0 2.0 2 0 0 2 2 2 0 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal PASTA PF03793.14 KOO52823.1 - 0.085 12.5 1.4 0.34 10.6 0.1 2.1 2 0 0 2 2 2 0 PASTA domain TPR_11 PF13414.1 KOO52824.1 - 8.2e-10 38.1 0.7 2.4e-09 36.6 0.5 1.9 1 1 0 1 1 1 1 TPR repeat TPR_9 PF13371.1 KOO52824.1 - 1.6e-08 34.2 2.7 1.6e-08 34.2 1.8 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO52824.1 - 7.5e-07 28.6 1.7 0.00067 19.3 0.5 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 KOO52824.1 - 4e-05 23.0 0.6 0.00017 21.0 0.2 2.3 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 KOO52824.1 - 0.002 18.0 3.0 0.0052 16.6 2.1 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO52824.1 - 0.008 15.8 0.1 0.062 13.1 0.0 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 KOO52824.1 - 0.051 13.7 0.2 0.23 11.7 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat NARP1 PF12569.3 KOO52824.1 - 0.055 12.2 0.3 0.085 11.5 0.2 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TPR_19 PF14559.1 KOO52824.1 - 0.2 12.0 2.8 0.88 9.9 1.5 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.1 KOO52824.1 - 0.62 10.8 10.1 0.45 11.2 3.5 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO52824.1 - 2.4 9.0 13.0 9.8 7.1 4.2 4.2 2 1 1 3 3 3 0 Tetratricopeptide repeat Syntaxin-6_N PF09177.6 KOO52826.1 - 1.3e-15 57.5 0.8 1.3e-15 57.5 0.5 2.0 2 1 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.14 KOO52826.1 - 1.2e-08 34.5 4.9 1.2e-08 34.5 3.4 2.0 2 0 0 2 2 2 1 SNARE domain Sec20 PF03908.8 KOO52826.1 - 0.00062 19.4 0.5 0.0019 17.8 0.1 1.9 1 1 0 1 1 1 1 Sec20 AAA_13 PF13166.1 KOO52826.1 - 0.049 12.1 0.6 0.061 11.7 0.4 1.1 1 0 0 1 1 1 0 AAA domain THOC7 PF05615.8 KOO52826.1 - 0.14 12.4 0.2 0.14 12.4 0.1 2.1 2 1 0 2 2 2 0 Tho complex subunit 7 DUF3322 PF11795.3 KOO52826.1 - 0.16 11.5 2.9 0.11 12.0 0.6 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) Reo_sigmaC PF04582.7 KOO52826.1 - 0.17 11.0 2.0 0.24 10.5 0.1 1.9 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Cep57_CLD PF14073.1 KOO52826.1 - 0.25 11.1 7.2 0.48 10.2 0.7 2.8 2 1 1 3 3 3 0 Centrosome localisation domain of Cep57 DUF812 PF05667.6 KOO52826.1 - 0.69 8.3 7.3 0.99 7.8 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) FliJ PF02050.11 KOO52826.1 - 0.72 9.9 12.8 0.44 10.6 4.5 2.6 2 1 1 3 3 3 0 Flagellar FliJ protein Bacillus_HBL PF05791.6 KOO52826.1 - 2.8 7.2 7.3 1.3 8.3 1.8 2.4 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF3450 PF11932.3 KOO52826.1 - 4.4 6.4 11.9 1.2 8.3 4.6 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) AA_permease_2 PF13520.1 KOO52828.1 - 0.00056 18.5 0.6 0.00073 18.1 0.5 1.1 1 0 0 1 1 1 1 Amino acid permease Ribosomal_L35p PF01632.14 KOO52829.1 - 0.015 15.2 6.3 0.037 13.9 4.3 1.8 1 0 0 1 1 1 0 Ribosomal protein L35 NPCBM_assoc PF10633.4 KOO52829.1 - 0.2 11.7 1.5 0.32 11.0 1.0 1.3 1 0 0 1 1 1 0 NPCBM-associated, NEW3 domain of alpha-galactosidase Peptidase_C2 PF00648.16 KOO52830.1 - 6.5e-27 94.3 0.0 1e-26 93.6 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease IQ PF00612.22 KOO52830.1 - 0.0016 17.9 1.4 1.2 8.9 0.1 2.7 2 0 0 2 2 2 2 IQ calmodulin-binding motif AAA_33 PF13671.1 KOO52830.1 - 0.018 14.9 0.2 0.049 13.4 0.1 1.7 1 0 0 1 1 1 0 AAA domain DUF2317 PF10079.4 KOO52830.1 - 0.18 10.4 0.1 0.29 9.6 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2317) Chloroplast_duf PF14476.1 KOO52831.1 - 0.043 12.6 1.1 0.061 12.1 0.7 1.2 1 0 0 1 1 1 0 Petal formation-expressed Phe_tRNA-synt_N PF02912.13 KOO52831.1 - 0.4 10.4 3.5 0.21 11.3 0.3 2.2 2 1 1 3 3 3 0 Aminoacyl tRNA synthetase class II, N-terminal domain Methyltransf_21 PF05050.7 KOO52832.1 - 5.2e-09 36.2 0.0 9e-09 35.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase FkbM domain Peptidase_S10 PF00450.17 KOO52833.1 - 8.7e-40 137.1 0.0 1.6e-37 129.7 0.0 2.0 1 1 0 1 1 1 1 Serine carboxypeptidase CAF1 PF04857.15 KOO52834.1 - 8e-63 212.2 0.1 1.2e-62 211.6 0.0 1.2 1 0 0 1 1 1 1 CAF1 family ribonuclease Rubis-subs-bind PF09273.6 KOO52835.1 - 2.9e-06 27.2 0.0 5e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.23 KOO52835.1 - 0.017 15.4 0.0 1.2 9.4 0.0 2.5 2 1 0 2 2 2 0 SET domain NAD_binding_1 PF00175.16 KOO52836.1 - 0.037 14.6 2.5 0.35 11.4 0.3 2.1 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain WD40 PF00400.27 KOO52837.1 - 3.5e-49 163.0 9.7 1.8e-05 24.4 0.0 12.6 13 0 0 13 13 13 9 WD domain, G-beta repeat EF-hand_8 PF13833.1 KOO52837.1 - 1.4e-09 37.3 2.9 2.7e-07 30.0 0.4 2.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.1 KOO52837.1 - 2.5e-09 37.1 0.7 8.1e-09 35.4 0.5 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO52837.1 - 3.3e-09 35.3 0.8 0.00093 18.3 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO52837.1 - 1.2e-08 33.8 1.6 0.00067 18.8 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO52837.1 - 1.7e-08 33.6 0.8 0.0013 18.4 0.0 3.2 2 0 0 2 2 2 2 EF-hand domain Nucleoporin_N PF08801.6 KOO52837.1 - 1.4e-06 27.3 1.1 0.15 10.7 0.0 4.8 3 2 2 5 5 5 2 Nup133 N terminal like Nup160 PF11715.3 KOO52837.1 - 6.6e-05 21.2 3.3 0.86 7.6 0.1 4.4 4 1 0 4 4 4 3 Nucleoporin Nup120/160 EF-hand_4 PF12763.2 KOO52837.1 - 0.00078 19.1 0.5 3.8 7.2 0.2 3.4 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand Phage_integrase PF00589.17 KOO52838.1 - 0.0004 20.0 0.1 0.00081 19.1 0.0 1.5 2 0 0 2 2 2 1 Phage integrase family Ank_2 PF12796.2 KOO52839.1 - 1.2e-27 96.0 3.3 1.2e-15 57.5 0.2 1.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO52839.1 - 1.3e-18 66.9 3.6 3.2e-08 33.8 0.2 3.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO52839.1 - 5.4e-15 54.3 0.1 8e-07 28.5 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 KOO52839.1 - 7.6e-12 45.0 0.4 1.3e-08 34.7 0.1 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO52839.1 - 4.4e-08 32.6 0.0 0.0004 20.3 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat HC2 PF07382.6 KOO52839.1 - 2.8e-05 24.0 20.7 2.8e-05 24.0 14.4 2.0 2 1 0 2 2 2 1 Histone H1-like nucleoprotein HC2 PT PF04886.7 KOO52839.1 - 0.011 14.9 8.0 0.025 13.9 5.5 1.5 1 0 0 1 1 1 0 PT repeat RNase_H2-Ydr279 PF09468.5 KOO52839.1 - 0.89 8.6 4.2 1.3 8.1 2.9 1.2 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) TraV PF09676.5 KOO52839.1 - 4.2 8.1 8.5 1.8 9.2 0.5 2.4 2 0 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) DUF2413 PF10310.4 KOO52839.1 - 8.9 5.0 13.0 0.26 10.0 3.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2413) Activator-TraM PF11657.3 KOO52841.1 - 0.25 10.8 2.9 0.31 10.5 2.0 1.2 1 0 0 1 1 1 0 Transcriptional activator TraM CCDC-167 PF15188.1 KOO52842.1 - 0.34 10.8 6.1 0.41 10.6 4.2 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF2077 PF09850.4 KOO52842.1 - 0.4 10.0 2.7 0.47 9.8 1.9 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2077) rRNA_processing PF08524.6 KOO52842.1 - 1.7 8.4 5.4 1.8 8.3 3.8 1.1 1 0 0 1 1 1 0 rRNA processing Kelch_1 PF01344.20 KOO52845.1 - 5.2e-27 93.1 0.3 1.2e-12 47.1 0.0 3.8 3 1 0 3 3 3 3 Kelch motif Kelch_6 PF13964.1 KOO52845.1 - 1.2e-21 75.9 0.0 1.3e-08 34.6 0.0 3.4 2 1 1 3 3 3 3 Kelch motif BACK PF07707.10 KOO52845.1 - 1.1e-16 60.4 0.1 1.7e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.26 KOO52845.1 - 2.9e-14 52.9 0.0 6.6e-14 51.8 0.0 1.6 2 0 0 2 2 2 1 BTB/POZ domain Kelch_3 PF13415.1 KOO52845.1 - 4.2e-14 52.2 2.1 4.6e-06 26.6 0.0 3.7 2 1 1 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.10 KOO52845.1 - 3.3e-13 48.8 0.0 4.8e-05 22.9 0.0 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.1 KOO52845.1 - 5.5e-13 48.4 0.0 0.0002 21.0 0.0 3.6 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO52845.1 - 0.0082 16.0 0.1 0.11 12.5 0.0 2.6 2 0 0 2 2 2 1 Kelch motif Skp1 PF01466.14 KOO52845.1 - 0.022 14.7 0.0 0.046 13.7 0.0 1.5 1 0 0 1 1 1 0 Skp1 family, dimerisation domain MerR-DNA-bind PF09278.6 KOO52846.1 - 0.062 13.6 25.7 0.21 12.0 4.6 3.5 3 0 0 3 3 3 0 MerR, DNA binding Drf_FH3 PF06367.11 KOO52846.1 - 0.063 12.6 0.8 0.1 12.0 0.5 1.4 1 0 0 1 1 1 0 Diaphanous FH3 Domain SlyX PF04102.7 KOO52846.1 - 0.17 12.2 18.2 1.6 9.1 0.6 3.4 3 0 0 3 3 3 0 SlyX ERM PF00769.14 KOO52846.1 - 0.2 11.1 36.2 0.13 11.7 4.8 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Spc7 PF08317.6 KOO52846.1 - 0.77 8.3 17.9 0.13 10.8 6.1 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Fic PF02661.13 KOO52846.1 - 5.1 7.8 6.1 1.9 9.2 0.6 2.4 1 1 1 2 2 2 0 Fic/DOC family DUF2382 PF09557.5 KOO52846.1 - 5.8 6.8 13.5 0.17 11.7 2.4 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF2382) YjcZ PF13990.1 KOO52848.1 - 0.0024 17.0 0.7 0.0041 16.2 0.5 1.4 1 0 0 1 1 1 1 YjcZ-like protein TPR_11 PF13414.1 KOO52848.1 - 0.0087 15.6 3.3 0.031 13.9 2.3 2.0 1 0 0 1 1 1 1 TPR repeat Filament PF00038.16 KOO52848.1 - 0.018 14.5 2.0 0.028 13.9 1.4 1.2 1 0 0 1 1 1 0 Intermediate filament protein Reo_sigmaC PF04582.7 KOO52848.1 - 0.058 12.5 0.0 0.095 11.8 0.0 1.3 1 0 0 1 1 1 0 Reovirus sigma C capsid protein DUF4164 PF13747.1 KOO52848.1 - 4.6 7.4 9.9 1 9.5 1.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) Pyr_redox_dim PF02852.17 KOO52849.1 - 1.3e-28 99.1 0.4 2.3e-28 98.3 0.3 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.9 KOO52849.1 - 2.3e-21 76.5 0.6 4.3e-21 75.7 0.1 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 KOO52849.1 - 8.7e-15 54.8 0.5 5e-14 52.4 0.1 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 KOO52849.1 - 6.1e-05 23.1 0.0 0.00026 21.1 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.14 KOO52849.1 - 0.0065 15.6 0.2 2.7 7.1 0.0 2.7 3 0 0 3 3 3 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K_oxygenase PF13434.1 KOO52849.1 - 0.093 11.6 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Pkinase PF00069.20 KOO52850.1 - 3.3e-52 177.2 0.0 3.8e-52 176.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO52850.1 - 1.2e-36 126.1 0.0 1.5e-36 125.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO52850.1 - 0.00018 20.6 0.0 0.00024 20.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like EF-hand_5 PF13202.1 KOO52851.1 - 0.0042 16.3 0.2 0.0085 15.3 0.1 1.5 1 0 0 1 1 1 1 EF hand TPR_9 PF13371.1 KOO52851.1 - 0.006 16.4 1.0 0.012 15.4 0.7 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat EF-hand_1 PF00036.27 KOO52851.1 - 0.012 14.8 0.0 0.027 13.7 0.0 1.6 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.1 KOO52851.1 - 0.072 13.2 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.1 KOO52851.1 - 0.15 12.0 0.1 0.41 10.6 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain Bestrophin PF01062.16 KOO52852.1 - 2.3e-21 76.0 0.0 1e-20 73.8 0.0 1.9 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Cation_efflux PF01545.16 KOO52853.1 - 4.3e-31 108.0 2.6 5.9e-31 107.6 1.8 1.1 1 0 0 1 1 1 1 Cation efflux family SLAC1 PF03595.12 KOO52853.1 - 2.2 6.8 10.2 0.068 11.8 1.4 2.2 2 1 0 2 2 2 0 Voltage-dependent anion channel LRR_9 PF14580.1 KOO52854.1 - 1e-09 38.2 0.7 2e-09 37.2 0.5 1.4 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.2 KOO52854.1 - 8.8e-08 31.6 10.7 8.5e-05 22.0 1.9 3.4 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO52854.1 - 6.3e-07 29.0 17.1 8.6e-06 25.4 2.6 2.6 1 1 2 3 3 3 3 Leucine rich repeat LRR_1 PF00560.28 KOO52854.1 - 0.43 10.8 5.0 1.5e+02 3.0 0.0 4.4 3 1 1 4 4 4 0 Leucine Rich Repeat EF-hand_1 PF00036.27 KOO52856.1 - 1.9e-14 51.7 1.5 1e-05 24.4 0.1 3.3 3 1 0 3 3 3 2 EF hand EF-hand_5 PF13202.1 KOO52856.1 - 1.6e-12 46.1 0.4 2.4e-05 23.4 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO52856.1 - 5.2e-12 44.5 0.4 0.00012 21.6 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO52856.1 - 1.3e-10 41.2 3.4 2.9e-10 40.1 1.1 2.5 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO52856.1 - 2.2e-07 30.3 1.1 1.4e-06 27.8 0.3 3.7 3 2 1 4 4 4 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO52856.1 - 0.0016 18.4 0.8 0.0016 18.4 0.5 2.0 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO52856.1 - 0.0036 17.0 0.4 0.0099 15.6 0.1 1.8 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand Rad52_Rad22 PF04098.10 KOO52856.1 - 0.036 13.7 0.1 0.078 12.7 0.0 1.6 2 0 0 2 2 2 0 Rad52/22 family double-strand break repair protein OrfB_IS605 PF01385.14 KOO52856.1 - 0.08 12.3 1.6 0.13 11.6 1.1 1.3 1 0 0 1 1 1 0 Probable transposase DUF2849 PF11011.3 KOO52856.1 - 0.23 11.7 2.2 3.1 8.1 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2849) DUF2362 PF10154.4 KOO52856.1 - 0.63 8.6 5.8 0.064 11.9 0.9 1.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2362) PNGaseA PF12222.3 KOO52858.1 - 1.4e-37 129.6 0.0 2.3e-26 92.6 0.0 2.2 2 0 0 2 2 2 2 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A Gly_transf_sug PF04488.10 KOO52859.1 - 0.0021 18.4 0.0 0.0037 17.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.7 KOO52859.1 - 0.022 13.9 0.0 0.029 13.5 0.0 1.1 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein TcdA_TcdB PF12919.2 KOO52859.1 - 0.11 10.9 0.0 0.2 10.1 0.0 1.4 1 1 1 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain SNF2_N PF00176.18 KOO52864.1 - 8.7e-09 34.5 0.0 1.5e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain SAP PF02037.22 KOO52864.1 - 2.9e-07 29.8 1.6 5.5e-07 28.9 0.4 2.1 2 0 0 2 2 2 1 SAP domain ResIII PF04851.10 KOO52864.1 - 0.023 14.5 0.0 0.073 12.8 0.0 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Arm PF00514.18 KOO52865.1 - 0.0029 17.3 0.4 0.58 10.0 0.0 2.7 3 1 0 3 3 3 2 Armadillo/beta-catenin-like repeat Aldedh PF00171.17 KOO52866.1 - 2.1e-90 303.3 0.2 2.6e-90 303.0 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 KOO52866.1 - 0.023 13.9 0.0 0.038 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) Mito_carr PF00153.22 KOO52867.1 - 7.4e-15 54.4 0.6 2.1e-06 27.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein QCR10 PF09796.4 KOO52867.1 - 0.25 11.0 1.4 6.9 6.4 0.2 2.5 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) C2 PF00168.25 KOO52868.1 - 0.00097 18.9 0.0 0.0019 18.0 0.0 1.5 1 0 0 1 1 1 1 C2 domain Apolipoprotein PF01442.13 KOO52868.1 - 0.0071 15.8 29.8 0.0071 15.8 20.6 4.4 1 1 3 4 4 4 1 Apolipoprotein A1/A4/E domain WD40 PF00400.27 KOO52869.1 - 2.8e-82 267.9 48.1 6.5e-12 44.8 0.5 10.3 10 0 0 10 10 10 7 WD domain, G-beta repeat PD40 PF07676.7 KOO52869.1 - 2.7e-12 46.0 4.6 2.2 8.0 0.0 7.5 7 0 0 7 7 7 5 WD40-like Beta Propeller Repeat AAA_16 PF13191.1 KOO52869.1 - 2.7e-09 37.2 2.7 2.1e-08 34.3 0.1 2.6 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.7 KOO52869.1 - 1.3e-07 31.4 0.0 2.6e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 NACHT domain KAP_NTPase PF07693.9 KOO52869.1 - 0.0058 15.6 0.0 0.54 9.1 0.0 2.6 3 0 0 3 3 3 1 KAP family P-loop domain AAA_22 PF13401.1 KOO52869.1 - 0.044 13.9 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain PIF1 PF05970.9 KOO52869.1 - 0.1 11.5 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase GPDPase_memb PF10110.4 KOO52869.1 - 0.54 9.6 0.0 0.9 8.9 0.0 1.3 1 0 0 1 1 1 0 Membrane domain of glycerophosphoryl diester phosphodiesterase AAA_2 PF07724.9 KOO52870.1 - 8.1e-52 175.5 0.0 5.3e-50 169.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 KOO52870.1 - 9.7e-25 87.2 0.0 3e-13 50.0 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 KOO52870.1 - 1.3e-17 63.8 0.0 5.5e-13 48.8 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) ClpB_D2-small PF10431.4 KOO52870.1 - 2.3e-13 49.8 0.0 8.5e-13 48.0 0.0 2.1 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein Sigma54_activat PF00158.21 KOO52870.1 - 1.2e-09 37.8 0.0 8.6e-06 25.3 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.1 KOO52870.1 - 1.2e-08 35.1 0.7 0.0034 17.5 0.0 4.0 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.1 KOO52870.1 - 3.9e-08 33.4 13.0 0.00032 20.7 0.0 5.3 5 2 0 7 7 7 2 AAA ATPase domain AAA_17 PF13207.1 KOO52870.1 - 5.7e-08 33.6 0.0 0.00098 19.9 0.0 3.4 3 0 0 3 3 3 2 AAA domain IstB_IS21 PF01695.12 KOO52870.1 - 1.4e-07 31.0 0.0 0.011 15.1 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.16 KOO52870.1 - 1.4e-06 27.6 0.5 0.29 10.2 0.1 3.8 3 1 0 3 3 3 2 Magnesium chelatase, subunit ChlI Clp_N PF02861.15 KOO52870.1 - 5.8e-06 26.1 1.9 2.3e-05 24.2 0.5 2.5 2 0 0 2 2 2 1 Clp amino terminal domain AAA_19 PF13245.1 KOO52870.1 - 1.5e-05 24.6 0.0 0.021 14.5 0.0 3.1 2 0 0 2 2 2 1 Part of AAA domain AAA_14 PF13173.1 KOO52870.1 - 2.6e-05 24.1 0.0 0.084 12.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain RuvB_N PF05496.7 KOO52870.1 - 2.7e-05 23.3 0.1 1.4 7.9 0.0 3.9 4 0 0 4 4 4 2 Holliday junction DNA helicase ruvB N-terminus Zeta_toxin PF06414.7 KOO52870.1 - 4e-05 22.8 0.0 0.0019 17.3 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin AAA_18 PF13238.1 KOO52870.1 - 8.5e-05 22.8 0.0 0.18 12.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 KOO52870.1 - 0.00042 20.0 0.0 0.15 11.6 0.0 2.8 2 1 0 2 2 2 1 NACHT domain Arch_ATPase PF01637.13 KOO52870.1 - 0.002 17.8 0.2 12 5.5 0.0 3.6 3 1 1 4 4 4 0 Archaeal ATPase AAA_25 PF13481.1 KOO52870.1 - 0.0022 17.4 0.0 0.23 10.8 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 KOO52870.1 - 0.0037 17.1 0.0 0.13 12.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.6 KOO52870.1 - 0.0058 16.2 0.0 1.4 8.5 0.0 3.1 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 KOO52870.1 - 0.0095 15.4 0.1 2.8 7.3 0.0 3.5 4 1 0 4 4 3 1 AAA-like domain RNA_helicase PF00910.17 KOO52870.1 - 0.011 15.8 0.0 2.6 8.2 0.0 2.5 2 0 0 2 2 2 0 RNA helicase AAA_29 PF13555.1 KOO52870.1 - 0.013 15.0 0.0 7.9 6.1 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain TIP49 PF06068.8 KOO52870.1 - 0.017 13.8 0.1 0.3 9.7 0.0 2.3 2 1 0 2 2 2 0 TIP49 C-terminus AAA_23 PF13476.1 KOO52870.1 - 0.022 15.0 0.0 9.6 6.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 KOO52870.1 - 0.025 13.7 0.0 3.3 6.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF258 MobB PF03205.9 KOO52870.1 - 0.029 14.0 0.0 2.4 7.8 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DNA_pol3_delta2 PF13177.1 KOO52870.1 - 0.029 14.0 0.0 0.4 10.3 0.0 2.4 1 1 0 1 1 1 0 DNA polymerase III, delta subunit NTPase_1 PF03266.10 KOO52870.1 - 0.03 14.0 0.3 13 5.4 0.0 3.4 3 0 0 3 3 3 0 NTPase ABC_tran PF00005.22 KOO52870.1 - 0.04 14.2 0.0 1.2 9.4 0.0 2.5 2 0 0 2 2 2 0 ABC transporter AAA_28 PF13521.1 KOO52870.1 - 0.041 13.8 0.0 6.6 6.6 0.0 2.9 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.17 KOO52870.1 - 0.096 11.5 0.0 15 4.3 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain Torsin PF06309.6 KOO52870.1 - 0.11 12.3 0.0 0.71 9.7 0.0 2.0 2 0 0 2 2 2 0 Torsin KTI12 PF08433.5 KOO52870.1 - 0.15 11.2 0.0 5.6 6.0 0.0 2.6 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Parvo_NS1 PF01057.12 KOO52870.1 - 0.19 10.5 0.0 7.3 5.3 0.0 2.3 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 RRM_1 PF00076.17 KOO52871.1 - 1.1e-12 47.3 0.0 1.6e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO52871.1 - 6.5e-11 42.0 0.0 1.1e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.19 KOO52871.1 - 7.3e-07 28.7 11.3 0.00054 19.5 1.8 2.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_5 PF13893.1 KOO52871.1 - 0.0013 18.5 0.0 0.0034 17.1 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CART PF06373.6 KOO52871.1 - 2.9 7.9 5.1 28 4.7 0.4 3.0 3 0 0 3 3 3 0 Cocaine and amphetamine regulated transcript protein (CART) FtsJ PF01728.14 KOO52872.1 - 0.0089 16.0 0.0 0.031 14.2 0.0 1.7 1 1 0 1 1 1 1 FtsJ-like methyltransferase PARP PF00644.15 KOO52873.1 - 9.9e-12 44.7 0.1 4.3e-11 42.6 0.1 2.0 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain HC2 PF07382.6 KOO52873.1 - 0.00075 19.4 10.6 0.0013 18.6 7.4 1.3 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 ACC_central PF08326.7 KOO52875.1 - 2.9e-37 128.2 0.2 3.7e-37 127.8 0.1 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Biotin_lipoyl PF00364.17 KOO52875.1 - 6.2e-06 25.7 0.4 3e-05 23.5 0.3 2.1 1 1 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.1 KOO52875.1 - 0.23 11.1 1.5 2.7 7.7 0.0 3.0 3 0 0 3 3 3 0 Biotin-lipoyl like ABC2_membrane PF01061.19 KOO52876.1 - 6.5e-31 107.1 22.9 6.5e-31 107.1 15.9 1.7 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.22 KOO52876.1 - 3e-09 37.2 0.0 4.6e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 KOO52876.1 - 0.0007 19.6 0.0 0.0011 18.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain PDR_CDR PF06422.7 KOO52876.1 - 0.11 12.1 0.3 0.11 12.1 0.2 2.5 2 1 1 3 3 3 0 CDR ABC transporter ABC2_membrane_3 PF12698.2 KOO52876.1 - 3.3 6.6 28.2 5.4 5.9 19.5 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein Methyltransf_16 PF10294.4 KOO52877.1 - 1.1e-13 51.0 0.0 2.3e-11 43.4 0.0 2.1 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 KOO52877.1 - 0.084 13.4 0.2 0.18 12.4 0.1 1.7 1 1 0 1 1 1 0 Methyltransferase domain Metallophos PF00149.23 KOO52878.1 - 4.7e-08 32.6 4.8 4.8e-08 32.6 2.1 1.9 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase Yae1_N PF09811.4 KOO52879.1 - 8.3e-07 28.4 10.8 1.4e-06 27.7 7.5 1.4 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Chorion_3 PF05387.6 KOO52879.1 - 3.8 6.8 4.8 5.2 6.4 3.3 1.2 1 0 0 1 1 1 0 Chorion family 3 EF-hand_7 PF13499.1 KOO52880.1 - 2.5e-24 85.1 1.5 4e-10 39.6 0.0 3.0 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.27 KOO52880.1 - 1.5e-23 80.2 1.3 2.6e-05 23.1 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO52880.1 - 4.6e-21 74.1 0.4 3.2e-06 26.6 0.0 4.3 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO52880.1 - 2.3e-19 67.4 4.1 0.00018 21.0 0.0 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.1 KOO52880.1 - 7.8e-17 59.7 9.8 9.2e-05 21.6 0.7 4.4 4 0 0 4 4 4 4 EF hand EF-hand_4 PF12763.2 KOO52880.1 - 4.9e-05 23.0 0.9 0.2 11.4 0.0 3.4 4 0 0 4 4 4 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO52880.1 - 0.0047 16.9 0.3 22 5.0 0.0 4.1 2 2 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region NARP1 PF12569.3 KOO52880.1 - 0.034 12.8 0.1 0.11 11.2 0.0 1.7 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 Toxin_65 PF15543.1 KOO52880.1 - 0.066 12.8 0.8 4.3 6.9 0.0 3.0 3 0 0 3 3 3 0 Putative toxin 65 Cleaved_Adhesin PF07675.6 KOO52880.1 - 0.14 11.7 1.5 0.55 9.8 0.1 2.4 2 1 1 3 3 3 0 Cleaved Adhesin Domain Baculo_PEP_C PF04513.7 KOO52880.1 - 2.9 7.7 5.7 24 4.7 0.0 3.6 3 2 2 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus EF-hand_7 PF13499.1 KOO52883.1 - 5e-22 77.8 0.7 1.4e-10 41.1 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO52883.1 - 2.4e-19 67.0 2.6 0.001 18.2 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO52883.1 - 3e-19 67.1 5.5 0.0014 18.3 0.0 4.8 4 0 0 4 4 4 4 EF-hand domain HAD_2 PF13419.1 KOO52883.1 - 5e-17 62.6 0.2 2.1e-16 60.6 0.1 2.1 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase EF-hand_5 PF13202.1 KOO52883.1 - 5.3e-17 60.3 3.3 0.00095 18.4 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO52883.1 - 1.8e-14 53.1 0.1 1.3e-07 31.0 0.0 3.3 2 1 1 3 3 3 2 EF-hand domain pair Hydrolase PF00702.21 KOO52883.1 - 1.3e-07 32.2 0.3 2.1e-07 31.5 0.2 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 KOO52883.1 - 1.6e-07 30.8 0.0 4e-07 29.6 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like SPARC_Ca_bdg PF10591.4 KOO52883.1 - 0.015 15.3 0.0 12 6.0 0.0 3.3 2 2 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.1 KOO52884.1 - 7.9e-14 50.2 0.1 2.6e-08 32.8 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.27 KOO52884.1 - 1.1e-13 49.4 0.1 6e-06 25.1 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO52884.1 - 1.3e-13 49.5 0.2 1.1e-05 24.8 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO52884.1 - 1e-09 37.8 0.0 0.00079 18.9 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.1 KOO52884.1 - 2e-08 34.2 0.1 0.007 16.4 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair TT_ORF2 PF02957.10 KOO52884.1 - 0.021 15.5 0.5 0.053 14.2 0.3 1.7 1 0 0 1 1 1 0 TT viral ORF2 SPX PF03105.14 KOO52885.1 - 0.38 10.4 1.6 0.93 9.2 0.9 1.6 1 1 0 1 1 1 0 SPX domain Gly-zipper_YMGG PF13441.1 KOO52887.1 - 1.1 8.8 7.3 2.4 7.7 5.0 1.5 1 0 0 1 1 1 0 YMGG-like Gly-zipper IQ PF00612.22 KOO52888.1 - 0.11 12.1 0.2 0.25 11.0 0.1 1.6 1 0 0 1 1 1 0 IQ calmodulin-binding motif CTDII PF01556.13 KOO52888.1 - 0.19 11.6 0.0 0.49 10.3 0.0 1.7 1 0 0 1 1 1 0 DnaJ C terminal domain Dimerisation PF08100.6 KOO52890.1 - 0.094 12.5 0.1 0.16 11.8 0.1 1.4 1 0 0 1 1 1 0 Dimerisation domain BING4CT PF08149.6 KOO52891.1 - 0.18 11.3 0.0 0.35 10.3 0.0 1.4 1 0 0 1 1 1 0 BING4CT (NUC141) domain SAC3_GANP PF03399.11 KOO52892.1 - 1.5e-50 171.6 0.1 1.8e-50 171.3 0.0 1.1 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family ABC1 PF03109.11 KOO52893.1 - 4.2e-32 110.6 0.0 1.2e-31 109.1 0.0 1.8 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 KOO52893.1 - 0.00028 20.7 0.0 0.01 15.5 0.0 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family CITED PF04487.7 KOO52893.1 - 0.26 11.4 0.1 0.48 10.6 0.1 1.4 1 0 0 1 1 1 0 CITED Ion_trans PF00520.26 KOO52894.1 - 3e-11 42.9 8.6 7.7e-11 41.6 6.0 1.6 1 1 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO52894.1 - 2e-06 27.4 5.6 2e-06 27.4 3.9 1.8 2 0 0 2 2 2 1 Ion channel Pkinase PF00069.20 KOO52895.1 - 9.8e-09 34.7 0.0 2e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO52895.1 - 7.5e-08 31.7 0.0 1.3e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pyr_redox PF00070.22 KOO52898.1 - 2.4e-07 31.0 0.1 1.2e-06 28.7 0.0 2.1 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 KOO52898.1 - 2.5e-07 29.9 0.2 0.00059 18.8 0.1 3.4 3 0 0 3 3 3 2 FAD dependent oxidoreductase HI0933_like PF03486.9 KOO52898.1 - 3.2e-05 22.5 0.0 5.6e-05 21.7 0.0 1.4 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.1 KOO52898.1 - 0.00024 21.0 0.1 0.00074 19.4 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 KOO52898.1 - 0.00043 19.2 0.1 0.0014 17.5 0.1 1.9 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 KOO52898.1 - 0.00096 19.0 0.0 0.002 18.0 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 KOO52898.1 - 0.0076 15.3 0.1 0.016 14.2 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.7 KOO52898.1 - 0.016 14.1 0.0 0.032 13.1 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_3 PF13738.1 KOO52898.1 - 0.025 14.6 0.0 0.054 13.5 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 KOO52898.1 - 0.036 13.1 0.0 0.075 12.1 0.0 1.4 1 0 0 1 1 1 0 Thi4 family 2-Hacid_dh_C PF02826.14 KOO52898.1 - 0.1 11.7 0.1 1.2 8.2 0.0 2.6 3 1 1 4 4 4 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain LRR_6 PF13516.1 KOO52899.1 - 0.0049 16.7 0.1 14 6.1 0.0 3.6 4 0 0 4 4 4 2 Leucine Rich repeat STAS_2 PF13466.1 KOO52899.1 - 0.016 15.1 2.3 0.032 14.2 0.1 2.2 2 0 0 2 2 2 0 STAS domain 4HB_MCP_1 PF12729.2 KOO52900.1 - 0.028 13.7 0.6 0.054 12.8 0.4 1.4 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction RPAP3_C PF13877.1 KOO52901.1 - 6.7e-14 51.6 0.0 3.3e-13 49.4 0.0 2.0 2 0 0 2 2 2 1 Potential Monad-binding region of RPAP3 TPR_11 PF13414.1 KOO52901.1 - 1.1e-10 40.9 22.6 1.1e-07 31.3 5.4 3.1 2 1 1 3 3 3 2 TPR repeat TPR_1 PF00515.23 KOO52901.1 - 1.3e-07 30.9 12.0 0.00045 19.7 0.2 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOO52901.1 - 6.9e-06 25.9 10.2 0.001 18.9 3.6 2.9 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO52901.1 - 1.2e-05 25.8 25.5 0.00015 22.3 5.5 6.2 5 2 3 8 8 8 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO52901.1 - 0.0001 21.9 20.5 0.0068 16.2 0.6 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO52901.1 - 0.01 15.5 2.5 1.1 9.1 0.1 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO52901.1 - 0.012 15.3 4.9 6 6.9 0.0 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.1 KOO52901.1 - 2.2 8.6 5.6 4.3 7.7 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO52901.1 - 2.7 8.6 14.9 38 5.0 0.1 5.2 4 1 0 4 4 4 0 Tetratricopeptide repeat PAN_4 PF14295.1 KOO52903.1 - 0.00056 19.5 1.3 0.0024 17.5 0.9 2.2 1 0 0 1 1 1 1 PAN domain PAN_1 PF00024.21 KOO52903.1 - 0.084 12.6 0.7 0.19 11.5 0.5 1.6 1 0 0 1 1 1 0 PAN domain RCC1 PF00415.13 KOO52905.1 - 1.1e-29 102.3 7.6 7.4e-14 51.6 0.4 3.9 3 1 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO52905.1 - 2.1e-14 52.6 16.7 2.3e-07 30.2 0.3 4.1 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat DUF2058 PF09831.4 KOO52906.1 - 0.99 9.2 9.1 1.5 8.6 6.3 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) Atrophin-1 PF03154.10 KOO52906.1 - 1.2 7.1 9.0 1.4 6.9 6.2 1.1 1 0 0 1 1 1 0 Atrophin-1 family Tmp39 PF10271.4 KOO52907.1 - 0.00096 17.9 1.2 0.39 9.3 0.0 2.0 2 0 0 2 2 2 2 Putative transmembrane protein PHO4 PF01384.15 KOO52908.1 - 0.033 12.8 0.0 0.046 12.3 0.0 1.2 1 0 0 1 1 1 0 Phosphate transporter family COX6B PF02297.12 KOO52908.1 - 0.045 13.7 0.0 0.095 12.7 0.0 1.5 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb MCM PF00493.18 KOO52910.1 - 1.9e-137 457.4 0.2 2.8e-137 456.9 0.2 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 KOO52910.1 - 5.1e-21 75.4 0.1 6e-20 71.9 0.0 2.7 3 0 0 3 3 3 1 MCM N-terminal domain Mg_chelatase PF01078.16 KOO52910.1 - 8.6e-07 28.3 0.0 6.5e-06 25.4 0.0 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 KOO52910.1 - 0.00022 20.9 0.0 0.00055 19.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 KOO52910.1 - 0.0027 17.2 0.0 0.0059 16.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 KOO52910.1 - 0.0034 16.8 0.0 0.007 15.8 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain SpoU_methylase PF00588.14 KOO52912.1 - 8.5e-10 38.6 0.0 1.2e-09 38.2 0.0 1.4 1 1 0 1 1 1 1 SpoU rRNA Methylase family Spore_YtfJ PF09579.5 KOO52912.1 - 0.038 13.8 2.6 0.08 12.8 1.8 1.5 1 0 0 1 1 1 0 Sporulation protein YtfJ (Spore_YtfJ) Fimbrial_K88 PF02432.10 KOO52912.1 - 0.05 13.0 0.0 0.075 12.4 0.0 1.3 1 1 0 1 1 1 0 Fimbrial, major and minor subunit CHORD PF04968.7 KOO52914.1 - 8.1e-46 154.1 19.2 4.8e-23 81.1 2.5 2.2 2 0 0 2 2 2 2 CHORD Pacs-1 PF10254.4 KOO52914.1 - 0.16 10.5 0.0 0.24 9.9 0.0 1.2 1 0 0 1 1 1 0 PACS-1 cytosolic sorting protein TRAM_LAG1_CLN8 PF03798.11 KOO52916.1 - 0.016 14.7 1.6 0.023 14.2 1.1 1.3 1 1 0 1 1 1 0 TLC domain Peptidase_M50B PF13398.1 KOO52917.1 - 5e-06 26.0 7.7 1.5e-05 24.4 5.4 1.8 1 1 0 1 1 1 1 Peptidase M50B-like CDP-OH_P_transf PF01066.16 KOO52917.1 - 4.2 7.7 10.1 37 4.6 7.0 2.5 1 1 0 1 1 1 0 CDP-alcohol phosphatidyltransferase zf-Tim10_DDP PF02953.10 KOO52918.1 - 3.2e-18 64.7 1.3 3.7e-18 64.5 0.9 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Peptidase_C34 PF05413.6 KOO52918.1 - 0.0089 16.0 0.2 0.012 15.6 0.1 1.3 1 0 0 1 1 1 1 Putative closterovirus papain-like endopeptidase KIAA1430 PF13879.1 KOO52919.1 - 8.6e-06 26.0 12.4 0.035 14.5 5.8 3.4 2 1 1 3 3 3 3 KIAA1430 homologue EFG_IV PF03764.13 KOO52919.1 - 0.28 10.7 3.9 4.6 6.8 0.1 2.9 3 0 0 3 3 3 0 Elongation factor G, domain IV DivIC PF04977.10 KOO52919.1 - 5.2 6.6 15.8 11 5.5 0.3 3.7 2 1 1 3 3 3 0 Septum formation initiator SR-25 PF10500.4 KOO52921.1 - 1.8 7.9 13.0 2.8 7.3 9.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.6 KOO52921.1 - 8.7 6.4 13.8 17 5.4 9.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Glyco_transf_28 PF03033.15 KOO52923.1 - 1.1e-16 60.8 0.1 3e-16 59.4 0.1 1.8 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Rotamase PF00639.16 KOO52923.1 - 8e-15 55.3 0.0 1.7e-14 54.2 0.0 1.6 2 0 0 2 2 2 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 KOO52923.1 - 7.3e-12 45.5 0.0 1.2e-11 44.8 0.0 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain UDPGT PF00201.13 KOO52923.1 - 2.3e-06 26.4 0.0 1.3e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.11 KOO52923.1 - 0.0066 16.1 0.0 0.014 15.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.1 KOO52923.1 - 0.075 12.7 0.1 1 9.0 0.1 2.4 1 1 0 1 1 1 0 Glycosyltransferase Family 4 Glyco_trans_1_3 PF13528.1 KOO52923.1 - 0.2 10.8 0.0 10 5.1 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family 1 Amidohydro_5 PF13594.1 KOO52924.1 - 0.13 12.0 0.4 0.23 11.3 0.3 1.5 1 0 0 1 1 1 0 Amidohydrolase 2-Hacid_dh_C PF02826.14 KOO52925.1 - 4.5e-42 143.1 0.0 1.3e-41 141.7 0.0 1.8 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 KOO52925.1 - 1.4e-19 69.8 0.0 2e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 KOO52925.1 - 0.00011 22.0 0.1 0.00022 21.1 0.1 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase XdhC_C PF13478.1 KOO52925.1 - 0.093 13.0 0.2 0.69 10.2 0.0 2.3 2 1 0 2 2 2 0 XdhC Rossmann domain DUF3313 PF11769.3 KOO52926.1 - 0.051 12.9 0.0 0.075 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3313) Prim-Pol PF09250.6 KOO52927.1 - 0.098 12.6 0.2 0.53 10.2 0.0 2.0 1 1 1 2 2 2 0 Bifunctional DNA primase/polymerase, N-terminal 2OG-FeII_Oxy_3 PF13640.1 KOO52928.1 - 0.00033 21.1 0.0 0.00063 20.2 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO52928.1 - 0.00056 20.1 0.0 0.0016 18.7 0.0 1.8 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF4175 PF13779.1 KOO52930.1 - 0.074 10.7 0.0 0.08 10.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Apolipoprotein PF01442.13 KOO52930.1 - 0.099 12.1 0.0 0.14 11.6 0.0 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain NDK PF00334.14 KOO52931.1 - 1.7e-38 131.4 0.0 2.1e-38 131.1 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase ATP12 PF07542.6 KOO52933.1 - 9.6e-34 115.9 0.0 1.6e-33 115.2 0.0 1.4 1 0 0 1 1 1 1 ATP12 chaperone protein Pkinase PF00069.20 KOO52934.1 - 3.4e-45 154.2 0.0 3.9e-45 154.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO52934.1 - 5.9e-20 71.4 0.0 7.3e-20 71.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO52934.1 - 0.0032 16.4 0.0 0.0053 15.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like DnaJ PF00226.26 KOO52935.1 - 7.5e-22 76.8 0.1 1.2e-21 76.1 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain DUF4398 PF14346.1 KOO52935.1 - 0.013 15.5 4.0 0.018 15.0 2.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4398) Sigma70_ner PF04546.8 KOO52935.1 - 0.014 15.0 1.1 0.015 14.8 0.8 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF1542 PF07564.6 KOO52935.1 - 0.048 13.6 1.5 0.078 12.9 1.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) UvdE PF03851.9 KOO52935.1 - 0.073 12.0 0.0 0.09 11.7 0.0 1.1 1 0 0 1 1 1 0 UV-endonuclease UvdE DENN PF02141.16 KOO52936.1 - 4.8e-10 39.4 4.6 8.2e-09 35.4 0.2 3.2 3 1 1 4 4 4 2 DENN (AEX-3) domain PDZ PF00595.19 KOO52936.1 - 6.9e-06 26.1 0.1 1.5e-05 25.0 0.1 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO52936.1 - 0.00068 19.4 0.0 0.0015 18.3 0.0 1.6 1 0 0 1 1 1 1 PDZ domain DUF2236 PF09995.4 KOO52937.1 - 2.7e-12 46.4 4.5 2.3e-07 30.3 0.4 2.3 1 1 1 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2236) FA_hydroxylase PF04116.8 KOO52938.1 - 3.8e-08 33.7 16.7 3.8e-08 33.7 11.6 1.8 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Lipase_GDSL_2 PF13472.1 KOO52939.1 - 0.00046 20.3 0.0 0.0011 19.1 0.0 1.8 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Pyr_redox_2 PF07992.9 KOO52940.1 - 5.6e-07 29.6 0.0 1.3e-06 28.4 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 KOO52940.1 - 1.7e-06 27.1 0.0 0.0057 15.6 0.0 2.2 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.22 KOO52940.1 - 1.8e-05 25.0 0.1 0.03 14.7 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 KOO52940.1 - 0.018 13.9 0.1 0.047 12.5 0.0 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase LRR_6 PF13516.1 KOO52941.1 - 7.4e-06 25.5 1.0 0.39 10.9 0.0 3.8 3 0 0 3 3 3 2 Leucine Rich repeat LRR_4 PF12799.2 KOO52941.1 - 0.027 14.0 0.6 1 9.0 0.0 3.1 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) Sfi1 PF08457.5 KOO52941.1 - 0.049 12.0 73.4 0.43 8.9 11.2 5.2 2 2 3 5 5 5 0 Sfi1 spindle body protein LRR_7 PF13504.1 KOO52941.1 - 6.3 7.4 5.7 3.6e+02 2.1 0.2 5.0 5 0 0 5 5 5 0 Leucine rich repeat WD40 PF00400.27 KOO52942.1 - 3.1e-50 166.3 22.9 3.8e-11 42.4 0.1 8.3 8 0 0 8 8 8 7 WD domain, G-beta repeat eIF2A PF08662.6 KOO52942.1 - 2.2e-09 37.3 0.5 0.00014 21.6 0.0 3.2 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.11 KOO52942.1 - 9.4e-06 24.1 0.4 0.4 8.9 0.0 3.5 2 1 1 3 3 3 3 Cytochrome D1 heme domain PD40 PF07676.7 KOO52942.1 - 0.00016 21.2 1.0 2.8 7.6 0.0 4.5 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat NACHT PF05729.7 KOO52942.1 - 0.00046 19.8 0.1 0.0023 17.6 0.1 2.1 2 1 0 2 2 2 1 NACHT domain BBS2_Mid PF14783.1 KOO52942.1 - 0.00057 19.6 0.5 3.1 7.6 0.0 4.0 2 1 2 4 4 4 2 Ciliary BBSome complex subunit 2, middle region RRM_1 PF00076.17 KOO52942.1 - 0.024 14.2 0.0 0.052 13.1 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup160 PF11715.3 KOO52942.1 - 0.036 12.1 2.6 1.6 6.7 0.0 2.9 2 1 0 2 2 2 0 Nucleoporin Nup120/160 WW PF00397.21 KOO52942.1 - 1.6 8.6 4.2 23 4.9 2.9 2.6 1 1 0 1 1 1 0 WW domain Agenet PF05641.7 KOO52943.1 - 2.2e-20 72.5 6.6 2.5e-06 27.5 0.1 5.5 4 1 0 4 4 4 3 Agenet domain GRIP PF01465.15 KOO52943.1 - 2.6e-09 36.4 0.2 6.1e-09 35.2 0.1 1.6 1 0 0 1 1 1 1 GRIP domain Spc7 PF08317.6 KOO52943.1 - 0.13 10.9 1.3 0.2 10.2 0.9 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Prominin PF05478.6 KOO52943.1 - 1.3 6.4 0.9 1.9 5.9 0.6 1.1 1 0 0 1 1 1 0 Prominin NT-C2 PF10358.4 KOO52944.1 - 2.5e-05 23.7 0.0 4.3e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins Tup_N PF08581.5 KOO52944.1 - 0.37 11.0 8.8 0.94 9.7 0.2 3.2 3 0 0 3 3 3 0 Tup N-terminal Aldo_ket_red PF00248.16 KOO52945.1 - 7.1e-46 156.2 0.0 8.1e-46 156.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Dynamitin PF04912.9 KOO52946.1 - 0.05 12.4 0.3 0.077 11.7 0.2 1.2 1 0 0 1 1 1 0 Dynamitin DUF3651 PF12371.3 KOO52948.1 - 0.00076 19.4 0.0 8.7 6.4 0.0 3.6 1 1 2 4 4 4 3 Protein of unknown function (DUF3651) DUF1156 PF06634.7 KOO52948.1 - 3.8 7.3 8.2 25 4.7 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1156) Sds3 PF08598.6 KOO52949.1 - 5.8e-06 25.9 3.3 1.3e-05 24.8 1.9 1.7 2 0 0 2 2 2 1 Sds3-like Big_3_3 PF13750.1 KOO52949.1 - 0.0078 15.6 0.0 0.027 13.8 0.0 1.7 2 0 0 2 2 2 1 Bacterial Ig-like domain (group 3) Asp PF00026.18 KOO52950.1 - 1.6e-101 339.7 0.0 4.2e-101 338.3 0.0 1.6 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 KOO52950.1 - 9.1e-10 38.7 0.0 1e-08 35.2 0.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 KOO52950.1 - 4.3e-06 27.1 0.1 0.098 13.1 0.0 3.2 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.1 KOO52950.1 - 7.2e-05 22.3 0.0 0.00022 20.7 0.0 1.8 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal Na_Ca_ex PF01699.19 KOO52951.1 - 6.2e-37 126.3 29.7 1.2e-20 73.5 8.7 3.0 2 1 0 2 2 2 2 Sodium/calcium exchanger protein EF-hand_7 PF13499.1 KOO52952.1 - 1e-13 51.2 3.5 1.1e-07 31.9 0.1 2.1 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.1 KOO52952.1 - 2.1e-09 36.4 0.4 0.00047 19.8 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO52952.1 - 2.4e-09 35.8 1.5 0.00025 20.1 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO52952.1 - 2.9e-08 32.6 1.2 1.1e-05 24.4 0.0 2.8 2 1 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO52952.1 - 1.6e-05 24.4 0.4 0.071 12.7 0.0 2.7 3 0 0 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO52952.1 - 0.037 14.0 0.0 0.2 11.7 0.0 2.0 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region DUF2075 PF09848.4 KOO52952.1 - 0.048 12.6 0.0 0.05 12.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DJ-1_PfpI PF01965.19 KOO52953.1 - 0.00023 20.6 0.0 0.00047 19.6 0.0 1.6 1 1 1 2 2 2 1 DJ-1/PfpI family LRR_6 PF13516.1 KOO52954.1 - 4.4e-31 103.4 1.3 0.00065 19.5 0.0 7.6 7 0 0 7 7 7 6 Leucine Rich repeat Ank_4 PF13637.1 KOO52954.1 - 9.2e-26 89.7 4.0 7.6e-09 35.8 0.1 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO52954.1 - 1.8e-24 84.2 3.3 4.5e-09 35.6 0.1 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.2 KOO52954.1 - 3.6e-23 81.7 2.0 2.4e-12 47.0 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO52954.1 - 5.8e-22 77.2 4.8 2.5e-10 40.2 0.3 2.9 1 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO52954.1 - 5e-15 54.1 0.6 0.0016 18.4 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat LRR_4 PF12799.2 KOO52954.1 - 3.5e-06 26.5 1.1 0.073 12.7 0.0 4.8 3 2 2 5 5 5 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO52954.1 - 4.5e-05 22.9 0.0 17 5.9 0.0 6.1 7 0 0 7 7 7 0 Leucine Rich Repeat LRR_7 PF13504.1 KOO52954.1 - 9.4e-05 22.0 0.8 60 4.5 0.0 6.3 7 0 0 7 7 7 0 Leucine rich repeat YycC PF14174.1 KOO52954.1 - 0.00016 21.3 0.1 4.8 6.9 0.0 5.2 6 0 0 6 6 6 1 YycC-like protein AmoA PF05145.7 KOO52954.1 - 0.0098 14.9 0.9 3.3 6.6 0.0 2.4 2 0 0 2 2 2 2 Putative ammonia monooxygenase DUF4235 PF14019.1 KOO52954.1 - 0.017 14.9 0.3 8.6 6.2 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4235) LRR_8 PF13855.1 KOO52954.1 - 0.038 13.7 1.2 4.2 7.1 0.2 3.9 3 1 2 5 5 5 0 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO52954.1 - 0.058 13.5 5.9 3.6 7.8 0.0 4.6 4 1 2 6 6 6 0 RNA 2'-O ribose methyltransferase substrate binding DUF4396 PF14342.1 KOO52954.1 - 0.058 13.5 0.6 4.1 7.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4396) YusW PF14039.1 KOO52954.1 - 0.18 12.1 0.5 12 6.2 0.1 2.9 2 1 1 3 3 3 0 YusW-like protein FIST_C PF10442.4 KOO52954.1 - 8.2 6.3 8.0 18 5.2 2.4 2.9 2 1 1 3 3 3 0 FIST C domain EF-hand_7 PF13499.1 KOO52955.1 - 2.9e-06 27.3 0.0 4.5e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO52955.1 - 8.9e-05 22.0 0.1 0.00025 20.5 0.1 1.8 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO52955.1 - 0.0013 18.4 1.1 0.075 12.9 0.1 2.8 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.27 KOO52955.1 - 0.0021 17.2 0.0 0.033 13.4 0.0 2.2 2 0 0 2 2 2 1 EF hand DUF4476 PF14771.1 KOO52956.1 - 1.5e-20 73.0 0.0 2.6e-09 36.9 0.0 3.4 1 1 2 3 3 3 2 Domain of unknown function (DUF4476) F5_F8_type_C PF00754.20 KOO52956.1 - 6.6e-08 32.4 0.1 1.3e-07 31.4 0.1 1.4 1 0 0 1 1 1 1 F5/8 type C domain Arm PF00514.18 KOO52957.1 - 6.1e-96 311.3 65.6 1.3e-08 34.3 0.2 12.3 12 0 0 12 12 12 12 Armadillo/beta-catenin-like repeat DNA_ligase_OB PF03120.11 KOO52957.1 - 1.2e-14 53.7 9.7 7.8 6.2 0.0 11.6 3 2 9 12 12 12 2 NAD-dependent DNA ligase OB-fold domain RPAP1_C PF08620.5 KOO52957.1 - 9.4e-13 47.8 0.1 42 4.0 0.0 10.5 10 1 1 11 11 11 0 RPAP1-like, C-terminal Arm_2 PF04826.8 KOO52957.1 - 5.1e-11 42.1 20.4 0.0046 16.0 0.5 6.1 1 1 6 7 7 7 7 Armadillo-like HEAT_EZ PF13513.1 KOO52957.1 - 7.2e-08 32.6 52.2 0.15 12.5 0.7 9.1 4 4 8 12 12 12 8 HEAT-like repeat HEAT_2 PF13646.1 KOO52957.1 - 3.1e-07 30.5 56.1 0.0036 17.5 6.5 6.5 1 1 7 8 8 8 7 HEAT repeats Atx10homo_assoc PF09759.4 KOO52957.1 - 1.2e-05 24.9 10.9 0.19 11.4 0.2 6.3 5 2 1 6 6 6 3 Spinocerebellar ataxia type 10 protein domain N1221 PF07923.8 KOO52957.1 - 9.4e-05 21.3 6.9 6.5 5.5 0.0 6.5 1 1 7 8 8 8 1 N1221-like protein HEAT PF02985.17 KOO52957.1 - 0.00015 21.5 22.1 38 4.7 0.0 11.1 13 0 0 13 13 13 0 HEAT repeat Peptidase_S41 PF03572.13 KOO52957.1 - 0.00019 20.8 5.8 7.1 6.0 0.0 6.7 2 2 1 4 4 4 2 Peptidase family S41 ACC_central PF08326.7 KOO52957.1 - 0.00022 19.5 1.8 15 3.4 0.0 6.0 1 1 7 9 9 9 0 Acetyl-CoA carboxylase, central region KAP PF05804.7 KOO52957.1 - 0.002 16.1 0.0 1.4 6.7 0.0 2.8 1 1 0 3 3 3 2 Kinesin-associated protein (KAP) SPOUT_MTase PF02590.12 KOO52957.1 - 0.0024 17.5 19.4 3.5 7.3 0.1 6.4 1 1 8 9 9 9 4 Predicted SPOUT methyltransferase DUF383 PF04063.9 KOO52957.1 - 0.0026 17.3 0.1 1.9 7.9 0.0 4.3 2 2 1 3 3 3 1 Domain of unknown function (DUF383) DUF1676 PF07898.8 KOO52957.1 - 0.017 15.4 6.9 1.8e+02 2.4 0.0 7.4 1 1 10 11 11 11 0 Protein of unknown function (DUF1676) Nif11 PF07862.6 KOO52957.1 - 0.042 13.7 0.3 0.17 11.8 0.2 2.1 1 0 0 1 1 1 0 Nitrogen fixation protein of unknown function Phage_integrase PF00589.17 KOO52958.1 - 0.0025 17.5 0.0 0.15 11.7 0.0 2.5 2 0 0 2 2 2 2 Phage integrase family Ank_2 PF12796.2 KOO52959.1 - 1.9e-18 66.5 0.0 2.4e-13 50.2 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO52959.1 - 2.1e-17 63.1 0.8 3.4e-09 36.9 0.0 2.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO52959.1 - 8.4e-17 60.8 0.7 3.6e-12 46.0 0.1 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.25 KOO52959.1 - 7.9e-16 56.9 0.1 3.5e-09 36.0 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.1 KOO52959.1 - 4e-08 32.7 0.0 1.7e-06 27.6 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeat Cupin_8 PF13621.1 KOO52960.1 - 7.5e-24 84.5 0.0 8.7e-23 81.0 0.0 2.0 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 KOO52960.1 - 6.8e-06 25.5 0.4 0.0015 17.8 0.1 2.9 3 0 0 3 3 3 2 Cupin superfamily protein Cupin_2 PF07883.6 KOO52960.1 - 0.023 14.1 0.2 0.054 12.9 0.1 1.6 1 0 0 1 1 1 0 Cupin domain JmjC PF02373.17 KOO52960.1 - 0.17 12.1 0.1 0.76 10.0 0.0 1.9 2 0 0 2 2 2 0 JmjC domain, hydroxylase SAM_2 PF07647.12 KOO52961.1 - 8e-11 41.6 1.6 1.4e-09 37.6 0.0 3.0 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 KOO52961.1 - 2e-08 34.2 0.0 6.5e-08 32.6 0.0 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.11 KOO52961.1 - 0.02 14.6 0.0 0.048 13.4 0.0 1.6 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain IGR PF09597.5 KOO52961.1 - 0.054 13.3 0.9 0.31 10.9 0.0 2.5 3 0 0 3 3 3 0 IGR protein motif Amidohydro_2 PF04909.9 KOO52961.1 - 0.11 12.0 0.2 0.11 12.0 0.1 2.8 2 1 1 3 3 3 0 Amidohydrolase TOMM6 PF15184.1 KOO52961.1 - 0.14 11.5 1.5 1.9 7.8 0.1 2.6 2 0 0 2 2 2 0 Mitochondrial import receptor subunit TOM6 homolog Sin3_corepress PF08295.7 KOO52961.1 - 0.14 11.8 3.6 1.1 9.0 0.1 2.4 2 0 0 2 2 2 0 Sin3 family co-repressor PARP PF00644.15 KOO52962.1 - 2.9e-16 59.5 0.0 7.6e-16 58.1 0.0 1.7 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain MMPL PF03176.10 KOO52962.1 - 0.26 9.9 1.8 0.43 9.2 1.3 1.2 1 0 0 1 1 1 0 MMPL family EamA PF00892.15 KOO52964.1 - 1.2e-07 31.7 25.4 0.0012 18.8 2.7 3.1 2 1 1 3 3 3 3 EamA-like transporter family EmrE PF13536.1 KOO52964.1 - 0.65 10.2 22.4 0.51 10.5 2.0 3.0 1 1 2 3 3 3 0 Multidrug resistance efflux transporter TPT PF03151.11 KOO52964.1 - 1.1 8.9 16.9 0.28 10.8 7.3 2.2 2 0 0 2 2 2 0 Triose-phosphate Transporter family DUF2668 PF10873.3 KOO52964.1 - 1.5 8.9 4.4 0.31 11.1 0.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2668) DUF2530 PF10745.4 KOO52964.1 - 5.4 7.0 10.2 2.4 8.2 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2530) DUF373 PF04123.8 KOO52964.1 - 6.6 5.6 11.6 9.2 5.1 8.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) SBBP PF06739.6 KOO52965.1 - 1.8e-11 43.6 40.0 0.0017 18.0 1.8 5.1 5 0 0 5 5 5 4 Beta-propeller repeat NMU PF02070.10 KOO52965.1 - 1.7 8.2 9.8 53 3.4 0.1 4.9 5 0 0 5 5 5 0 Neuromedin U HTH_1 PF00126.22 KOO52966.1 - 0.72 9.6 0.1 0.72 9.6 0.1 2.2 3 0 0 3 3 3 0 Bacterial regulatory helix-turn-helix protein, lysR family LRR_5 PF13306.1 KOO52967.1 - 8.6e-74 245.3 2.9 1.2e-36 125.2 0.3 2.1 2 0 0 2 2 2 2 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO52967.1 - 1e-15 57.1 0.0 0.00097 18.8 0.0 6.0 2 2 6 8 8 8 5 Leucine rich repeat LRR_4 PF12799.2 KOO52967.1 - 0.041 13.5 0.0 5.4 6.7 0.0 2.9 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) MitoNEET_N PF10660.4 KOO52967.1 - 0.062 13.1 1.1 44 4.0 0.0 4.3 3 1 3 6 6 6 0 Iron-containing outer mitochondrial membrane protein N-terminus DUF2070 PF09843.4 KOO52971.1 - 0.1 12.0 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) RVT_1 PF00078.22 KOO52973.1 - 0.00034 20.0 0.0 0.00048 19.5 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TetR PF13972.1 KOO52975.1 - 0.15 11.4 0.0 0.3 10.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial transcriptional repressor tRNA-synt_2b PF00587.20 KOO52976.1 - 1.1e-44 152.1 0.0 1.6e-44 151.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 KOO52976.1 - 3.6e-23 81.3 0.1 8.3e-23 80.1 0.1 1.7 1 0 0 1 1 1 1 Anticodon binding domain WHEP-TRS PF00458.15 KOO52976.1 - 1.1e-07 31.3 8.6 1.1e-07 31.3 6.0 2.3 2 1 0 2 2 2 1 WHEP-TRS domain GUB_WAK_bind PF13947.1 KOO52976.1 - 0.07 13.6 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 Wall-associated receptor kinase galacturonan-binding DUF1180 PF06679.7 KOO52976.1 - 0.38 10.6 4.5 0.81 9.5 3.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) HAD PF12710.2 KOO52979.1 - 3.2e-17 63.3 0.0 6.6e-17 62.3 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 KOO52979.1 - 2.9e-09 37.6 1.7 4.8e-08 33.6 0.1 2.2 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Aph-1 PF06105.7 KOO52979.1 - 9.1e-06 25.0 7.9 1.3e-05 24.5 5.5 1.2 1 0 0 1 1 1 1 Aph-1 protein Acid_phosphat_B PF03767.9 KOO52979.1 - 0.00015 21.2 0.0 0.0058 16.0 0.0 2.1 2 0 0 2 2 2 1 HAD superfamily, subfamily IIIB (Acid phosphatase) Put_Phosphatase PF06888.7 KOO52979.1 - 0.00015 21.0 0.0 0.00025 20.3 0.0 1.3 1 1 0 1 1 1 1 Putative Phosphatase UMPH-1 PF05822.7 KOO52979.1 - 0.0033 16.7 0.0 0.0053 16.0 0.0 1.3 1 1 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) Hint PF01079.15 KOO52979.1 - 0.041 13.0 0.0 0.056 12.6 0.0 1.2 1 0 0 1 1 1 0 Hint module HAD_2 PF13419.1 KOO52979.1 - 0.057 13.6 0.0 0.13 12.4 0.0 1.6 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase EF-hand_10 PF14788.1 KOO52979.1 - 0.13 11.9 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 EF hand Pirin_C PF05726.8 KOO52980.1 - 4.8e-27 94.0 0.0 7.7e-27 93.4 0.0 1.3 1 0 0 1 1 1 1 Pirin C-terminal cupin domain Pirin PF02678.11 KOO52980.1 - 4.4e-14 52.2 0.1 9.6e-14 51.1 0.1 1.6 1 0 0 1 1 1 1 Pirin cNMP_binding PF00027.24 KOO52983.1 - 6.8e-25 86.7 0.0 3.1e-14 52.5 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain SHIPPO-rpt PF07004.7 KOO52983.1 - 2.6e-10 40.6 14.3 0.088 13.7 0.1 6.4 6 0 0 6 6 6 5 Sperm-tail PG-rich repeat COPI_assoc PF08507.5 KOO52984.1 - 1.7e-13 50.3 1.1 2.2e-13 50.0 0.8 1.1 1 0 0 1 1 1 1 COPI associated protein DUF1469 PF07332.6 KOO52985.1 - 0.064 12.9 0.3 0.099 12.3 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) Tom7 PF08038.7 KOO52985.1 - 0.092 12.2 0.2 0.092 12.2 0.1 2.4 3 0 0 3 3 3 0 TOM7 family DUF2781 PF10914.3 KOO52985.1 - 0.83 9.4 6.2 1.2 8.9 4.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2781) GpcrRhopsn4 PF10192.4 KOO52985.1 - 1 8.5 5.0 0.42 9.7 1.4 1.7 2 0 0 2 2 2 0 Rhodopsin-like GPCR transmembrane domain Cellulase PF00150.13 KOO52986.1 - 8.4e-12 44.8 0.0 1.1e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF914 PF06027.7 KOO52987.1 - 1.4e-71 241.1 2.8 1.9e-71 240.6 2.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF914) UAA PF08449.6 KOO52987.1 - 2.1e-07 30.1 0.0 2.8e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 KOO52987.1 - 0.001 19.0 1.6 0.001 19.0 1.1 2.9 3 0 0 3 3 3 2 EamA-like transporter family TPT PF03151.11 KOO52987.1 - 0.0012 18.4 12.0 0.0026 17.4 1.3 2.7 3 0 0 3 3 3 2 Triose-phosphate Transporter family EmrE PF13536.1 KOO52987.1 - 0.0014 18.8 4.4 0.0014 18.8 3.0 2.8 3 1 0 3 3 3 1 Multidrug resistance efflux transporter FUSC-like PF12805.2 KOO52987.1 - 9 5.1 8.1 0.84 8.5 0.5 2.8 2 2 0 2 2 2 0 FUSC-like inner membrane protein yccS Cullin PF00888.17 KOO52989.1 - 3.9e-170 567.2 7.2 4.7e-170 567.0 5.0 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 KOO52989.1 - 1.8e-28 98.1 3.1 1.4e-27 95.3 0.9 3.1 3 0 0 3 3 3 1 Cullin protein neddylation domain GerPC PF10737.4 KOO52989.1 - 0.077 12.7 0.1 0.077 12.7 0.0 2.7 3 0 0 3 3 3 0 Spore germination protein GerPC DUF2493 PF10686.4 KOO52989.1 - 0.16 11.5 0.0 0.56 9.7 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2493) SF3a60_bindingd PF12108.3 KOO52989.1 - 0.36 10.3 2.2 0.82 9.2 0.0 2.7 2 0 0 2 2 2 0 Splicing factor SF3a60 binding domain UvrD_C PF13361.1 KOO52991.1 - 8.2e-30 104.4 0.0 2.8e-18 66.4 0.0 2.1 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.1 KOO52991.1 - 0.0067 16.5 0.0 0.016 15.3 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain DUF2057 PF09829.4 KOO52991.1 - 0.26 10.9 0.6 0.52 9.9 0.4 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) PI3_PI4_kinase PF00454.22 KOO52993.1 - 0.0094 15.4 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase EF-hand_6 PF13405.1 KOO52994.1 - 1.8e-22 77.1 6.0 1.2e-05 24.7 0.2 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.27 KOO52994.1 - 2e-21 73.5 7.9 1.3e-05 24.1 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO52994.1 - 8.6e-21 73.8 2.7 5.1e-11 42.5 0.2 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO52994.1 - 4.8e-14 50.9 10.1 0.0014 17.8 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO52994.1 - 2.8e-12 46.0 5.5 2.6e-06 26.9 0.4 3.5 2 1 1 3 3 3 3 EF-hand domain pair IQ PF00612.22 KOO52994.1 - 0.11 12.2 5.2 4.2 7.2 0.1 3.0 2 0 0 2 2 2 0 IQ calmodulin-binding motif Syntaxin PF00804.20 KOO52994.1 - 0.68 10.1 9.8 0.15 12.2 0.7 3.4 3 1 0 3 3 3 0 Syntaxin Filamin PF00630.14 KOO52995.1 - 7.5e-25 87.4 0.0 3.9e-20 72.2 0.0 2.6 2 0 0 2 2 2 2 Filamin/ABP280 repeat Big_1 PF02369.11 KOO52995.1 - 0.0041 17.0 0.9 0.015 15.2 0.0 2.4 2 0 0 2 2 2 1 Bacterial Ig-like domain (group 1) Neurexophilin PF06312.7 KOO52995.1 - 0.021 14.0 0.0 0.038 13.2 0.0 1.4 1 0 0 1 1 1 0 Neurexophilin Mic1 PF07035.7 KOO52996.1 - 6.9e-26 90.5 0.0 1.2e-25 89.8 0.0 1.3 1 0 0 1 1 1 1 Colon cancer-associated protein Mic1-like Ank_2 PF12796.2 KOO52997.1 - 1e-14 54.6 0.2 3.5e-07 30.4 0.0 1.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO52997.1 - 1.3e-06 28.4 0.3 3.5e-06 27.0 0.2 1.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.25 KOO52997.1 - 7.6e-06 25.4 1.5 2.4e-05 23.9 0.1 2.5 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.1 KOO52997.1 - 0.001 19.5 0.1 0.013 16.0 0.0 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) PMEI PF04043.10 KOO52997.1 - 0.084 12.7 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor Atg14 PF10186.4 KOO52998.1 - 0.00096 18.1 6.5 0.0028 16.6 0.3 2.1 2 0 0 2 2 2 1 UV radiation resistance protein and autophagy-related subunit 14 KfrA_N PF11740.3 KOO52998.1 - 0.012 16.0 6.3 0.012 16.0 4.4 3.4 3 0 0 3 3 3 0 Plasmid replication region DNA-binding N-term Fez1 PF06818.10 KOO52998.1 - 0.067 13.2 15.4 0.24 11.3 6.3 2.1 2 0 0 2 2 2 0 Fez1 EMP24_GP25L PF01105.19 KOO52998.1 - 0.2 11.3 3.0 3.1 7.4 0.0 2.8 3 0 0 3 3 3 0 emp24/gp25L/p24 family/GOLD Erp_C PF06780.6 KOO52998.1 - 0.23 11.2 0.5 11 5.8 0.1 2.3 2 1 0 2 2 2 0 Erp protein C-terminus WEMBL PF05701.6 KOO52998.1 - 0.28 9.6 19.7 0.36 9.2 7.3 2.1 2 0 0 2 2 2 0 Weak chloroplast movement under blue light GAS PF13851.1 KOO52998.1 - 0.61 9.2 12.5 0.66 9.1 2.6 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding APG6 PF04111.7 KOO52998.1 - 0.63 9.0 12.5 2.3 7.1 3.6 2.2 2 0 0 2 2 2 0 Autophagy protein Apg6 ADIP PF11559.3 KOO52998.1 - 0.91 9.4 17.4 0.83 9.5 1.5 2.4 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding HrpB7 PF09486.5 KOO52998.1 - 1.2 9.0 25.7 0.4 10.6 10.2 2.3 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) TMF_DNA_bd PF12329.3 KOO52998.1 - 2 8.2 15.9 0.75 9.6 2.5 2.7 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding HAUS5 PF14817.1 KOO52998.1 - 2.2 6.7 19.6 0.54 8.7 7.4 2.0 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 5 DUF3135 PF11333.3 KOO52998.1 - 2.3 8.4 11.8 2.1 8.5 0.2 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3135) HlyD PF00529.15 KOO52998.1 - 3.8 6.7 16.9 0.29 10.4 4.6 2.2 2 0 0 2 2 2 0 HlyD family secretion protein Mnd1 PF03962.10 KOO52998.1 - 6.3 6.4 9.8 1.7 8.2 1.8 2.1 2 0 0 2 2 2 0 Mnd1 family LSM PF01423.17 KOO52999.1 - 1.8e-10 40.1 0.0 2.9e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 LSM domain Cortex-I_coil PF09304.5 KOO53001.1 - 0.00064 19.7 2.8 0.00064 19.7 1.9 5.1 3 1 3 6 6 6 2 Cortexillin I, coiled coil Reo_sigmaC PF04582.7 KOO53001.1 - 0.11 11.7 21.0 0.056 12.6 0.2 4.3 3 1 0 4 4 4 0 Reovirus sigma C capsid protein Metallophos PF00149.23 KOO53003.1 - 2.1e-23 82.8 0.0 2.8e-23 82.3 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase CAP_GLY PF01302.20 KOO53003.1 - 1.6e-19 69.3 0.3 2.9e-19 68.5 0.2 1.4 1 0 0 1 1 1 1 CAP-Gly domain Pkinase_Tyr PF07714.12 KOO53005.1 - 0.016 14.2 0.0 0.023 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase LRR_6 PF13516.1 KOO53006.1 - 8.6e-11 40.7 0.0 0.039 14.0 0.0 4.4 4 0 0 4 4 4 4 Leucine Rich repeat PMSI1 PF15322.1 KOO53006.1 - 3.6 6.5 7.0 0.42 9.6 2.1 1.6 2 0 0 2 2 2 0 Protein missing in infertile sperm 1, putative Methyltransf_23 PF13489.1 KOO53007.1 - 9.6e-17 61.1 0.0 1.5e-16 60.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO53007.1 - 6.8e-13 49.1 0.0 1.5e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO53007.1 - 3.5e-11 43.4 0.0 7.4e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO53007.1 - 4.3e-09 36.7 0.0 2.8e-08 34.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO53007.1 - 8.9e-09 35.4 0.7 2.3e-08 34.0 0.5 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO53007.1 - 5.2e-07 29.9 0.0 1.1e-06 28.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO53007.1 - 7.7e-07 28.8 0.0 1.2e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.1 KOO53007.1 - 2e-05 25.3 0.0 0.00013 22.7 0.0 2.2 3 0 0 3 3 2 1 Methyltransferase domain MTS PF05175.9 KOO53007.1 - 0.00013 21.3 0.0 0.00047 19.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain HAMP PF00672.20 KOO53007.1 - 0.0076 16.4 0.1 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 HAMP domain PrmA PF06325.8 KOO53007.1 - 0.033 13.3 0.0 0.05 12.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.7 KOO53007.1 - 0.038 13.3 0.0 0.059 12.7 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Thioredoxin PF00085.15 KOO53008.1 - 9.1e-39 131.3 0.0 3.4e-18 65.2 0.0 3.2 3 0 0 3 3 3 3 Thioredoxin Thioredoxin_6 PF13848.1 KOO53008.1 - 9.5e-17 61.3 0.0 9.2e-05 22.3 0.0 3.1 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.1 KOO53008.1 - 2.8e-08 33.9 0.1 0.0079 16.3 0.1 4.1 2 2 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.1 KOO53008.1 - 1.4e-05 24.9 0.0 0.21 11.6 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.1 KOO53008.1 - 0.00023 21.2 0.0 3 8.0 0.0 3.4 2 1 1 3 3 3 1 Thioredoxin-like Thioredoxin_4 PF13462.1 KOO53008.1 - 0.0014 18.7 0.0 0.0044 17.0 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin PAS_9 PF13426.1 KOO53009.1 - 5.9e-05 23.3 0.0 0.016 15.5 0.0 2.3 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.5 KOO53009.1 - 0.012 15.6 0.1 0.63 10.0 0.0 2.4 3 0 0 3 3 3 0 PAS fold Peptidase_M24 PF00557.19 KOO53011.1 - 1.9e-28 99.4 1.1 2.4e-28 99.1 0.7 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Acetyltransf_1 PF00583.19 KOO53013.1 - 2.8e-14 52.8 0.0 7.2e-14 51.5 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 KOO53013.1 - 1.9e-06 27.9 0.1 4.6e-06 26.7 0.1 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 KOO53013.1 - 6.5e-06 25.8 0.0 1.7e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.1 KOO53013.1 - 2.1e-05 24.6 0.0 3.8e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 KOO53013.1 - 0.00033 20.6 0.0 0.00049 20.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 KOO53013.1 - 0.00063 19.6 0.0 0.001 18.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 KOO53013.1 - 0.0013 18.5 0.0 0.0027 17.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.1 KOO53013.1 - 0.0059 16.3 0.1 0.013 15.1 0.1 1.7 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase Coa1 PF08695.5 KOO53013.1 - 0.013 14.9 0.1 0.023 14.1 0.1 1.3 1 0 0 1 1 1 0 Cytochrome oxidase complex assembly protein 1 Acetyltransf_3 PF13302.1 KOO53013.1 - 0.041 14.0 0.0 0.073 13.2 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Dynein_heavy PF03028.10 KOO53014.1 - 6.9e-33 113.6 0.0 8.3e-33 113.3 0.0 1.0 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor Oligomerisation PF02410.10 KOO53014.1 - 0.1 12.6 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Oligomerisation domain PRMT5 PF05185.11 KOO53016.1 - 8.5e-132 440.2 0.0 1e-131 439.9 0.0 1.0 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_26 PF13659.1 KOO53016.1 - 0.0034 17.3 0.1 0.0072 16.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO53016.1 - 0.11 12.9 0.0 0.28 11.5 0.0 1.7 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.7 KOO53016.1 - 0.11 13.0 0.0 0.19 12.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Sel1 PF08238.7 KOO53018.1 - 2.5e-06 27.9 4.2 0.00017 22.0 0.2 2.9 3 0 0 3 3 3 2 Sel1 repeat TPR_12 PF13424.1 KOO53018.1 - 0.00024 20.9 6.8 0.011 15.6 0.6 2.5 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO53018.1 - 0.0004 20.9 6.1 0.0004 20.9 4.2 2.4 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.1 KOO53018.1 - 0.0058 16.5 1.2 0.0058 16.5 0.8 3.2 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_4 PF07721.9 KOO53018.1 - 0.0092 16.3 0.9 0.0092 16.3 0.6 3.6 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO53018.1 - 0.022 14.6 0.4 0.022 14.6 0.3 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO53018.1 - 0.059 13.2 5.8 0.35 10.7 4.0 2.1 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOO53018.1 - 0.13 12.1 0.9 0.69 9.8 0.0 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO53018.1 - 1.1 10.0 14.5 0.21 12.3 2.5 3.1 1 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO53018.1 - 1.5 9.4 6.2 68 4.2 2.4 3.4 2 1 0 2 2 2 0 Tetratricopeptide repeat APOBEC_N PF08210.6 KOO53020.1 - 1.5e-39 135.5 0.2 5.4e-20 71.8 0.0 2.1 2 0 0 2 2 2 2 APOBEC-like N-terminal domain Ank_2 PF12796.2 KOO53021.1 - 7.5e-80 263.3 51.0 3e-16 59.5 1.2 5.2 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO53021.1 - 8.6e-33 111.6 24.3 6.3e-07 29.4 0.9 8.2 1 1 7 8 8 8 8 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO53021.1 - 3.5e-32 110.2 6.2 4e-07 30.3 0.0 6.7 5 2 2 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.25 KOO53021.1 - 7.5e-32 107.5 39.6 0.0003 20.4 0.1 9.9 10 0 0 10 10 10 8 Ankyrin repeat Ank_3 PF13606.1 KOO53021.1 - 8.6e-15 53.3 13.7 0.18 12.1 0.0 9.5 9 0 0 9 9 9 4 Ankyrin repeat DUF1118 PF06549.7 KOO53021.1 - 3.9e-12 46.3 7.6 2.3e-11 43.8 5.3 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1118) SicP-binding PF09119.5 KOO53021.1 - 2.8 7.7 7.6 1.5e+02 2.2 0.0 5.8 5 2 2 7 7 7 0 SicP binding PAM2 PF07145.10 KOO53022.1 - 0.02 14.3 1.3 0.046 13.2 0.9 1.6 1 0 0 1 1 1 0 Ataxin-2 C-terminal region LON PF02190.11 KOO53022.1 - 0.15 11.6 0.0 0.37 10.4 0.0 1.6 2 0 0 2 2 2 0 ATP-dependent protease La (LON) domain DUF3517 PF12030.3 KOO53022.1 - 0.18 10.3 0.0 0.27 9.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3517) Pkinase PF00069.20 KOO53023.1 - 7.3e-66 221.9 0.0 9.2e-66 221.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO53023.1 - 2.5e-33 115.2 0.0 3.3e-33 114.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO53023.1 - 0.00068 18.6 0.0 0.0013 17.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO53023.1 - 0.0064 16.2 2.6 0.0064 16.2 1.8 2.5 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 KOO53023.1 - 0.053 12.5 0.4 0.14 11.1 0.1 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-H2C2_2 PF13465.1 KOO53024.1 - 2.3e-16 59.1 25.8 2.8e-06 27.3 1.2 4.1 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.21 KOO53024.1 - 2.5e-14 52.6 17.9 8.9e-06 25.7 0.9 3.2 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOO53024.1 - 2.9e-11 42.8 14.6 0.002 18.3 0.9 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger CHORD PF04968.7 KOO53024.1 - 0.001 19.2 14.6 0.59 10.4 0.4 3.1 1 1 2 3 3 3 3 CHORD zf-C2H2_jaz PF12171.3 KOO53024.1 - 0.012 15.7 7.9 2.9 8.1 0.3 3.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding GAGA PF09237.6 KOO53024.1 - 0.019 14.5 0.2 0.075 12.6 0.0 1.9 2 0 0 2 2 2 0 GAGA factor Zn-ribbon_8 PF09723.5 KOO53024.1 - 0.052 13.5 6.6 4.3 7.3 0.2 3.2 3 0 0 3 3 3 0 Zinc ribbon domain zf-C2H2_6 PF13912.1 KOO53024.1 - 0.059 13.2 11.3 0.91 9.5 1.0 3.6 3 1 0 3 3 3 0 C2H2-type zinc finger zf-C2HC_2 PF13913.1 KOO53024.1 - 0.062 12.9 5.6 16 5.2 0.1 3.5 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-CGNR PF11706.3 KOO53024.1 - 0.079 12.4 4.6 6.1 6.4 0.1 3.3 3 0 0 3 3 3 0 CGNR zinc finger Fer2 PF00111.22 KOO53024.1 - 0.086 12.6 6.5 8.2 6.2 0.1 3.1 3 0 0 3 3 3 0 2Fe-2S iron-sulfur cluster binding domain XPA_N PF01286.13 KOO53024.1 - 0.091 12.4 2.4 34 4.2 0.0 3.3 3 0 0 3 3 3 0 XPA protein N-terminal FANCL_C PF11793.3 KOO53024.1 - 0.14 12.1 6.1 13 5.8 0.1 3.1 1 1 2 3 3 3 0 FANCL C-terminal domain Ogr_Delta PF04606.7 KOO53024.1 - 0.68 9.6 5.2 19 4.9 0.1 3.0 1 1 2 3 3 3 0 Ogr/Delta-like zinc finger CLCA_N PF08434.6 KOO53024.1 - 0.79 8.8 4.8 3 6.9 0.1 2.6 1 1 1 2 2 2 0 Calcium-activated chloride channel Peptidase_S8 PF00082.17 KOO53026.1 - 2.1e-26 92.7 1.2 3.2e-26 92.1 0.3 1.6 1 1 0 1 1 1 1 Subtilase family P_proprotein PF01483.15 KOO53026.1 - 2e-09 37.1 0.1 7.1e-08 32.1 0.0 2.4 2 0 0 2 2 2 1 Proprotein convertase P-domain MRP-L20 PF12824.2 KOO53027.1 - 5.9e-05 23.0 0.0 0.00011 22.1 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Bot1p PF12298.3 KOO53027.1 - 0.036 14.0 0.0 0.068 13.1 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic mitochondrial regulator protein FeoC PF09012.5 KOO53027.1 - 0.12 12.0 0.0 0.3 10.8 0.0 1.6 1 0 0 1 1 1 0 FeoC like transcriptional regulator MYCBPAP PF14646.1 KOO53028.1 - 2.6e-25 89.0 1.5 1.9e-20 73.0 0.0 2.5 3 0 0 3 3 3 2 MYCBP-associated protein family EF-hand_7 PF13499.1 KOO53028.1 - 6.9e-16 58.1 0.1 1.1e-08 35.0 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO53028.1 - 4.5e-15 53.7 3.1 9.3e-05 21.4 0.2 4.6 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.1 KOO53028.1 - 2.8e-10 39.1 10.3 0.021 14.7 0.0 5.5 6 0 0 6 6 6 3 EF-hand domain EF-hand_8 PF13833.1 KOO53028.1 - 2.9e-10 39.5 0.1 6.7e-09 35.2 0.0 4.9 4 2 2 6 6 6 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO53028.1 - 1.5e-08 33.5 3.6 0.0013 17.9 0.0 4.1 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.4 KOO53028.1 - 0.0078 16.2 0.0 2.7 8.0 0.0 3.2 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region DUF1456 PF07308.8 KOO53028.1 - 0.087 12.8 0.2 48 4.0 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1456) TraB PF01963.12 KOO53029.1 - 4.1e-06 26.4 0.1 7.1e-06 25.6 0.1 1.4 1 0 0 1 1 1 1 TraB family ADIP PF11559.3 KOO53030.1 - 0.0065 16.3 6.6 0.0065 16.3 4.6 3.6 1 1 2 3 3 3 1 Afadin- and alpha -actinin-Binding Tht1 PF04163.7 KOO53030.1 - 0.057 11.8 0.3 0.089 11.1 0.2 1.4 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein ATG16 PF08614.6 KOO53030.1 - 0.89 9.3 37.3 0.086 12.6 9.4 2.5 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF2762 PF10960.3 KOO53030.1 - 6.2 6.6 18.8 0.57 9.9 0.5 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF2762) DUF3811 PF11656.3 KOO53031.1 - 0.0063 16.5 6.8 0.007 16.4 4.7 1.0 1 0 0 1 1 1 1 YjbD family (DUF3811) DUF912 PF06024.7 KOO53031.1 - 0.34 10.9 4.5 0.39 10.7 3.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF3886 PF13025.1 KOO53031.1 - 0.63 10.0 10.1 0.75 9.7 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3886) eIF_4EBP PF05456.6 KOO53031.1 - 0.66 9.6 3.3 0.7 9.5 2.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) RNA_pol_Rpc4 PF05132.9 KOO53031.1 - 6.1 6.8 6.5 6.8 6.6 4.5 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 Ion_trans PF00520.26 KOO53032.1 - 2.2e-11 43.3 9.6 3e-11 42.9 6.6 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.7 KOO53032.1 - 6.4e-07 28.1 3.0 1.1e-06 27.3 2.1 1.4 1 0 0 1 1 1 1 Polycystin cation channel DUF2206 PF09971.4 KOO53032.1 - 0.64 8.7 2.8 0.96 8.1 2.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) Kinesin PF00225.18 KOO53033.1 - 6.2e-106 353.8 0.0 8e-106 353.5 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Acyl-CoA_dh_1 PF00441.19 KOO53035.1 - 0.56 10.2 6.0 0.22 11.6 1.3 2.5 1 1 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain Hpt PF01627.18 KOO53036.1 - 0.071 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Hpt domain BON PF04972.12 KOO53037.1 - 0.12 12.1 0.1 1.9 8.3 0.0 2.4 2 0 0 2 2 2 0 BON domain YjbE PF11106.3 KOO53037.1 - 0.71 9.8 10.5 1.3 8.9 7.3 1.4 1 0 0 1 1 1 0 Exopolysaccharide production protein YjbE Pkinase PF00069.20 KOO53038.1 - 6.8e-11 41.8 0.0 1.3e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO53038.1 - 1.1e-08 34.4 0.0 2.4e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Fib_alpha PF08702.5 KOO53039.1 - 0.067 13.3 5.8 0.8 9.8 0.6 2.6 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family CENP-F_leu_zip PF10473.4 KOO53039.1 - 0.068 13.0 26.9 0.21 11.4 7.5 4.1 1 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Mod_r PF07200.8 KOO53039.1 - 0.37 10.7 20.1 0.11 12.4 0.6 3.4 1 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein TPD52 PF04201.10 KOO53039.1 - 0.62 9.7 11.1 1.6 8.4 0.4 2.8 2 1 0 2 2 2 0 Tumour protein D52 family AAA_13 PF13166.1 KOO53039.1 - 2.7 6.3 12.6 1.4 7.3 0.5 2.0 1 1 1 2 2 2 0 AAA domain SPX PF03105.14 KOO53039.1 - 3.6 7.2 9.0 4.5 6.9 6.2 1.3 1 1 0 1 1 1 0 SPX domain Filament PF00038.16 KOO53039.1 - 4 6.8 29.8 1.2 8.4 0.4 3.2 1 1 2 3 3 3 0 Intermediate filament protein CENP-H PF05837.7 KOO53039.1 - 8.6 6.5 16.5 0.2 11.8 3.1 3.2 1 1 2 3 3 3 0 Centromere protein H (CENP-H) DUF3366 PF11846.3 KOO53040.1 - 0.036 13.9 0.2 0.049 13.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3366) MCPVI PF02993.9 KOO53040.1 - 6.4 6.8 8.1 7 6.7 5.6 1.3 1 0 0 1 1 1 0 Minor capsid protein VI RR_TM4-6 PF06459.7 KOO53040.1 - 9.8 5.9 9.1 11 5.8 6.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TIG PF01833.19 KOO53041.1 - 7.1e-32 109.2 0.3 2.6e-07 30.5 0.0 6.0 5 1 0 5 5 5 5 IPT/TIG domain Mitofilin PF09731.4 KOO53042.1 - 0.00088 18.0 1.5 0.00088 18.0 1.0 2.1 2 0 0 2 2 2 1 Mitochondrial inner membrane protein PAT1 PF09770.4 KOO53042.1 - 3.4 5.7 34.4 4.8 5.2 23.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 2OG-FeII_Oxy_3 PF13640.1 KOO53043.1 - 2.8e-08 34.1 0.0 4.7e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO53043.1 - 2.9e-07 30.6 0.0 4.3e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.1 KOO53043.1 - 0.00037 20.0 0.0 0.00085 18.9 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF2838 PF10998.3 KOO53044.1 - 2.4e-31 107.8 8.6 4.2e-31 107.0 6.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2838) Galactosyl_T PF01762.16 KOO53045.1 - 9.1e-08 31.9 0.0 2.1e-07 30.7 0.0 1.5 2 0 0 2 2 2 1 Galactosyltransferase TPR_11 PF13414.1 KOO53046.1 - 2.3e-16 59.1 27.3 0.00017 21.1 0.4 6.6 6 0 0 6 6 6 5 TPR repeat TPR_2 PF07719.12 KOO53046.1 - 5.2e-13 47.8 32.8 0.0035 17.1 0.5 8.9 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_1 PF00515.23 KOO53046.1 - 8.5e-10 37.8 26.8 0.014 14.9 0.2 7.8 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_12 PF13424.1 KOO53046.1 - 1.7e-09 37.4 32.1 0.0013 18.6 0.6 8.2 7 2 2 9 9 8 4 Tetratricopeptide repeat TPR_10 PF13374.1 KOO53046.1 - 0.00024 20.9 16.0 0.032 14.1 2.5 6.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO53046.1 - 0.00062 19.7 4.7 40 4.7 0.1 6.5 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO53046.1 - 0.0017 18.7 40.1 0.092 13.4 1.7 9.6 9 3 3 12 12 10 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO53046.1 - 0.0029 18.2 41.0 0.006 17.2 1.0 8.6 9 0 0 9 9 8 2 Tetratricopeptide repeat DUF2284 PF10050.4 KOO53046.1 - 0.0065 16.0 0.5 0.013 15.0 0.3 1.4 1 0 0 1 1 1 1 Predicted metal-binding protein (DUF2284) TPR_19 PF14559.1 KOO53046.1 - 0.015 15.6 32.4 1.1 9.6 0.2 8.0 8 0 0 8 8 8 0 Tetratricopeptide repeat DUF3808 PF10300.4 KOO53046.1 - 0.022 13.3 0.2 0.057 11.9 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) TPR_7 PF13176.1 KOO53046.1 - 0.035 13.9 21.2 0.15 11.9 0.4 7.7 9 0 0 9 9 9 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO53046.1 - 0.2 11.5 5.4 1.2 9.0 0.5 3.3 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.9 KOO53046.1 - 0.42 11.1 24.6 0.13 12.7 1.3 7.5 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOO53046.1 - 0.58 10.0 10.4 66 3.6 0.0 6.6 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO53046.1 - 1.1 9.8 23.4 1.1 9.9 0.2 7.3 9 0 0 9 9 9 0 Tetratricopeptide repeat Glyco_transf_34 PF05637.7 KOO53047.1 - 2.9e-08 33.5 0.1 1.1e-07 31.5 0.1 1.8 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Nucleotid_trans PF03407.11 KOO53047.1 - 0.015 15.1 0.0 0.025 14.3 0.0 1.4 1 1 0 1 1 1 0 Nucleotide-diphospho-sugar transferase DEAD PF00270.24 KOO53048.1 - 2.2e-43 147.6 0.0 7.2e-43 146.0 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO53048.1 - 1.8e-25 88.6 0.1 5.5e-25 87.0 0.0 1.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO53048.1 - 0.00038 20.3 0.0 0.0017 18.1 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF1253 PF06862.7 KOO53048.1 - 0.00078 17.9 0.1 0.021 13.2 0.0 2.6 3 1 0 3 3 3 1 Protein of unknown function (DUF1253) CMS1 PF14617.1 KOO53048.1 - 0.028 13.4 0.0 0.028 13.4 0.0 2.3 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.1 KOO53048.1 - 0.053 13.6 0.2 0.24 11.5 0.2 2.1 1 1 0 1 1 1 0 AAA domain GTP_EFTU PF00009.22 KOO53049.1 - 2.8e-33 114.9 0.3 2.9e-32 111.6 0.2 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 KOO53049.1 - 2.5e-18 65.9 0.3 6.4e-18 64.6 0.2 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.18 KOO53049.1 - 5.4e-07 29.5 0.0 1.1e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.20 KOO53049.1 - 2.2e-06 27.6 3.0 0.00071 19.6 0.1 3.3 2 1 1 3 3 3 2 Elongation factor Tu domain 2 PduV-EutP PF10662.4 KOO53049.1 - 2.2e-05 23.9 0.1 8.1e-05 22.1 0.1 1.9 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Ras PF00071.17 KOO53049.1 - 3.2e-05 23.3 0.0 5.5e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO53049.1 - 4.7e-05 23.8 0.0 0.00012 22.6 0.0 1.7 2 0 0 2 2 2 1 Miro-like protein FeoB_N PF02421.13 KOO53049.1 - 0.00042 19.6 0.1 0.0023 17.2 0.0 2.3 2 1 0 2 2 2 1 Ferrous iron transport protein B SRPRB PF09439.5 KOO53049.1 - 0.00097 18.3 0.0 0.0016 17.6 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit IF2_N PF04760.10 KOO53049.1 - 0.0057 16.2 0.0 1.2 8.8 0.0 2.9 3 0 0 3 3 3 1 Translation initiation factor IF-2, N-terminal region Dynamin_N PF00350.18 KOO53049.1 - 0.015 15.1 0.0 6.8 6.4 0.0 2.4 1 1 1 2 2 2 0 Dynamin family DUF460 PF04312.8 KOO53049.1 - 0.05 13.1 0.1 0.42 10.1 0.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF460) TPR_7 PF13176.1 KOO53050.1 - 5.4e-08 32.0 1.3 0.0061 16.2 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO53050.1 - 1.6e-07 30.7 1.6 0.0028 17.4 0.0 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOO53050.1 - 6.1e-07 29.0 12.0 1.1e-06 28.1 0.3 3.8 4 1 0 4 4 4 2 TPR repeat TPR_14 PF13428.1 KOO53050.1 - 8.3e-07 29.1 20.5 0.019 15.5 0.2 6.5 4 1 2 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOO53050.1 - 1.6e-06 28.3 6.4 7.2e-05 23.0 0.4 3.4 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO53050.1 - 6.2e-06 26.0 6.1 0.0024 17.7 0.6 4.3 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO53050.1 - 8.6e-06 26.2 0.4 8.6e-06 26.2 0.3 4.7 3 2 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO53050.1 - 0.0004 19.9 0.0 0.038 13.7 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO53050.1 - 0.00097 18.6 1.8 0.0035 16.8 0.0 2.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOO53050.1 - 0.011 15.6 0.9 0.011 15.6 0.6 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Apc3 PF12895.2 KOO53050.1 - 0.027 14.6 1.9 0.41 10.8 0.3 3.2 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.4 KOO53050.1 - 0.053 12.9 0.3 2.1 7.7 0.0 2.4 1 1 1 2 2 2 0 26S proteasome subunit RPN7 Alkyl_sulf_dimr PF14863.1 KOO53050.1 - 0.084 13.0 0.5 0.2 11.8 0.3 1.6 1 0 0 1 1 1 0 Alkyl sulfatase dimerisation TPR_20 PF14561.1 KOO53050.1 - 0.15 12.2 7.0 0.49 10.5 0.1 3.8 2 2 3 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.1 KOO53051.1 - 7.4e-19 67.1 13.3 2.6e-14 52.6 0.6 2.9 3 0 0 3 3 3 2 TPR repeat TPR_2 PF07719.12 KOO53051.1 - 2.6e-11 42.5 18.4 0.00014 21.4 0.0 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO53051.1 - 4.2e-11 41.9 8.6 6.2e-05 22.4 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat CS PF04969.11 KOO53051.1 - 1e-08 35.5 0.0 2e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 CS domain TPR_17 PF13431.1 KOO53051.1 - 3.6e-08 32.9 0.4 0.028 14.5 0.0 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO53051.1 - 9.8e-06 26.1 12.7 0.0004 20.9 0.8 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO53051.1 - 1.8e-05 24.9 7.8 0.0017 18.8 0.5 4.0 2 1 2 4 4 3 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO53051.1 - 0.0002 21.1 2.1 0.0002 21.1 1.4 2.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO53051.1 - 0.00027 20.4 0.7 1.3 8.9 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO53051.1 - 0.0068 16.3 0.1 0.0068 16.3 0.1 3.2 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOO53051.1 - 0.018 15.3 7.8 0.86 9.9 0.3 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat IpaC_SipC PF09599.5 KOO53051.1 - 0.025 13.6 0.6 0.039 12.9 0.4 1.2 1 0 0 1 1 1 0 Salmonella-Shigella invasin protein C (IpaC_SipC) Apc3 PF12895.2 KOO53051.1 - 0.031 14.4 3.5 0.89 9.7 0.2 2.8 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 KOO53051.1 - 0.12 12.8 10.9 0.18 12.3 0.0 4.5 5 0 0 5 5 4 0 Tetratricopeptide repeat Alpha_kinase PF02816.13 KOO53052.1 - 3.8e-21 75.6 0.6 2.3e-19 69.8 0.0 3.4 2 1 0 2 2 2 1 Alpha-kinase family Ank_2 PF12796.2 KOO53052.1 - 3e-16 59.5 0.0 8.3e-16 58.1 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO53052.1 - 4e-14 51.5 0.0 8.1e-06 25.3 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 KOO53052.1 - 2.8e-10 40.0 0.3 0.00053 20.1 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO53052.1 - 4.3e-10 38.8 0.0 0.0027 17.7 0.0 3.2 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.1 KOO53052.1 - 2.2e-09 37.5 0.0 0.00099 19.5 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) VWA_2 PF13519.1 KOO53052.1 - 2.8e-05 24.2 3.7 5.5e-05 23.3 0.0 2.8 3 0 0 3 3 3 1 von Willebrand factor type A domain NifU PF01106.12 KOO53053.1 - 4.5e-07 29.5 0.2 1.4e-05 24.8 0.0 2.3 2 1 0 2 2 2 2 NifU-like domain PC_rep PF01851.17 KOO53054.1 - 2.7e-20 71.4 14.4 0.00011 22.2 0.0 7.3 8 0 0 8 8 8 4 Proteasome/cyclosome repeat HEAT_2 PF13646.1 KOO53054.1 - 7.9e-08 32.4 2.6 0.014 15.6 0.1 4.2 3 1 0 3 3 3 2 HEAT repeats MitMem_reg PF13012.1 KOO53056.1 - 3.3e-35 120.6 0.2 5.9e-35 119.8 0.1 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.16 KOO53056.1 - 3.3e-26 91.2 0.3 7.2e-26 90.1 0.0 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CwfJ_C_1 PF04677.10 KOO53057.1 - 1.8e-20 72.8 0.0 2.4e-20 72.3 0.0 1.2 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.9 KOO53057.1 - 5.5e-11 42.8 0.0 2.5e-10 40.7 0.0 1.9 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 ARID PF01388.16 KOO53058.1 - 6.2e-21 74.0 0.0 1.2e-20 73.1 0.0 1.4 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.12 KOO53058.1 - 1.2e-09 37.5 0.0 2.2e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 jmjN domain PCI PF01399.22 KOO53059.1 - 5.2e-10 39.5 0.1 2.6e-09 37.3 0.0 2.2 2 0 0 2 2 2 1 PCI domain TPR_8 PF13181.1 KOO53059.1 - 0.059 13.1 1.1 0.15 11.8 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 KOO53059.1 - 0.06 13.2 0.3 0.33 10.9 0.2 2.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOO53059.1 - 1.8 8.3 4.1 0.72 9.5 0.3 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat DmsC PF04976.7 KOO53059.1 - 4.1 6.5 7.3 0.2 10.8 0.6 2.1 2 1 1 3 3 3 0 DMSO reductase anchor subunit (DmsC) PDZ PF00595.19 KOO53060.1 - 1e-19 70.4 0.3 0.003 17.6 0.0 4.5 4 0 0 4 4 4 4 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO53060.1 - 4.3e-15 55.3 4.8 0.024 14.5 0.1 4.5 4 0 0 4 4 4 4 PDZ domain DUF3394 PF11874.3 KOO53060.1 - 6.3e-05 22.5 0.0 9.7 5.6 0.0 4.5 4 0 0 4 4 4 1 Domain of unknown function (DUF3394) TctC PF03401.9 KOO53060.1 - 8.5e-05 21.6 9.4 0.13 11.1 0.0 4.2 4 0 0 4 4 4 2 Tripartite tricarboxylate transporter family receptor FAA_hydrolase_N PF09298.6 KOO53060.1 - 0.00043 20.2 0.4 40 4.2 0.0 4.5 4 0 0 4 4 4 0 Fumarylacetoacetase N-terminal DUF1948 PF09185.5 KOO53060.1 - 0.00056 19.5 0.0 9.3 5.8 0.0 4.0 4 0 0 4 4 4 1 Domain of unknown function (DUF1948) Coiled-coil_56 PF09813.4 KOO53060.1 - 0.015 15.2 0.2 21 5.2 0.0 4.2 4 0 0 4 4 4 0 Coiled-coil domain-containing protein 56 zf-LSD1 PF06943.7 KOO53060.1 - 0.035 13.7 0.1 1.1e+02 2.4 0.0 3.9 4 0 0 4 4 4 0 LSD1 zinc finger Poly_export PF02563.11 KOO53060.1 - 0.049 13.3 0.9 73 3.2 0.0 4.0 4 0 0 4 4 4 0 Polysaccharide biosynthesis/export protein RVT_2 PF07727.9 KOO53061.1 - 1.1e-09 37.6 0.1 1.7e-09 37.0 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) FAIM1 PF06905.8 KOO53061.1 - 0.096 11.8 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Fas apoptotic inhibitory molecule (FAIM1) DSPn PF14671.1 KOO53062.1 - 3.3e-43 147.0 0.0 6.6e-43 146.0 0.0 1.5 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.15 KOO53062.1 - 2.2e-10 40.2 0.0 4.1e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KOO53062.1 - 4.9e-07 29.3 0.0 1.4e-06 27.8 0.0 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 KOO53062.1 - 0.00012 22.3 0.0 0.00024 21.3 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.1 KOO53062.1 - 0.00014 21.9 0.0 0.00025 21.1 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate RNB PF00773.14 KOO53063.1 - 0.0011 18.3 0.7 0.0014 17.9 0.5 1.2 1 0 0 1 1 1 1 RNB domain Pyr_redox PF00070.22 KOO53065.1 - 2.5e-05 24.5 0.0 4.2e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 KOO53065.1 - 0.00082 19.3 0.0 0.025 14.4 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Ubiquitin_3 PF14836.1 KOO53066.1 - 0.11 12.1 0.1 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain DUF3761 PF12587.3 KOO53066.1 - 1.5 8.9 3.8 2.8 8.1 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3761) cwf21 PF08312.7 KOO53067.1 - 1.4e-05 24.8 12.0 4.1 7.3 0.2 7.2 4 2 2 6 6 6 2 cwf21 domain BBP1_C PF15272.1 KOO53067.1 - 2.5 7.6 22.9 0.46 10.0 1.5 4.2 3 1 0 3 3 3 0 Spindle pole body component BBP1, C-terminal Ubiquitin_3 PF14836.1 KOO53068.1 - 0.0043 16.6 0.7 0.062 12.9 0.1 2.2 1 1 0 2 2 2 1 Ubiquitin-like domain DUF2175 PF09943.4 KOO53068.1 - 0.038 14.0 6.0 0.49 10.4 0.9 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) L-fibroin PF05849.6 KOO53068.1 - 0.043 13.1 0.1 0.76 9.0 0.0 2.1 2 0 0 2 2 2 0 Fibroin light chain (L-fibroin) Nucleotid_trans PF03407.11 KOO53070.1 - 4.5e-09 36.4 0.0 6.5e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Laminin_G_3 PF13385.1 KOO53071.1 - 7.7e-11 42.4 0.0 8.8e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Ribosomal_L14 PF00238.14 KOO53072.1 - 3.8e-40 136.4 0.8 4.4e-40 136.2 0.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Acetyltransf_1 PF00583.19 KOO53073.1 - 2.7e-09 36.9 0.0 6.3e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 KOO53073.1 - 3.9e-06 26.9 0.0 7.1e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 KOO53073.1 - 0.00016 21.7 0.1 0.00043 20.3 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain YaeQ PF07152.7 KOO53073.1 - 0.025 13.9 0.0 0.038 13.3 0.0 1.2 1 0 0 1 1 1 0 YaeQ protein FR47 PF08445.5 KOO53073.1 - 0.039 13.6 0.0 0.1 12.3 0.0 1.7 1 0 0 1 1 1 0 FR47-like protein Abhydrolase_6 PF12697.2 KOO53075.1 - 7.2e-12 45.6 3.5 7.2e-12 45.6 2.4 2.3 2 1 0 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 KOO53075.1 - 0.00019 21.0 0.4 0.00043 19.9 0.2 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 KOO53075.1 - 0.00094 18.9 0.3 0.002 17.9 0.2 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family EF-hand_1 PF00036.27 KOO53076.1 - 3.8e-13 47.7 0.3 5.7e-06 25.2 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO53076.1 - 7.7e-13 47.1 0.0 4.2e-06 26.1 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 KOO53076.1 - 5.4e-12 45.6 0.0 7.8e-12 45.1 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO53076.1 - 2.4e-09 36.1 0.8 9.6e-06 24.7 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO53076.1 - 5.2e-07 29.1 0.0 0.0051 16.4 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair Ribosomal_L23 PF00276.15 KOO53079.1 - 1.2e-12 47.6 0.2 1.5e-12 47.2 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L23 Ank_2 PF12796.2 KOO53080.1 - 1.5e-38 131.0 15.2 2.9e-17 62.7 1.4 3.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 KOO53080.1 - 1.1e-29 102.2 15.2 5.5e-07 29.9 0.1 5.1 2 1 4 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.25 KOO53080.1 - 6e-26 88.9 30.4 0.00036 20.1 0.2 7.4 7 0 0 7 7 7 7 Ankyrin repeat Ank_5 PF13857.1 KOO53080.1 - 1.4e-24 85.4 21.9 6.3e-08 32.6 0.9 6.5 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO53080.1 - 4.8e-12 44.8 14.9 0.11 12.8 0.1 7.8 8 0 0 8 8 8 4 Ankyrin repeat DUF4182 PF13790.1 KOO53080.1 - 1.3e-06 28.0 1.3 1.2 8.9 0.0 4.9 6 0 0 6 6 6 2 Domain of unknown function (DUF4182) LIN37 PF15306.1 KOO53080.1 - 0.041 13.8 3.6 44 4.0 0.0 4.6 6 0 0 6 6 6 0 LIN37 Phospholip_A2_2 PF05826.7 KOO53080.1 - 0.14 12.1 7.7 4.4 7.3 0.2 3.4 1 1 4 5 5 5 0 Phospholipase A2 Hex_IIIa PF02455.11 KOO53080.1 - 1.3 7.5 6.7 1.8 7.1 4.6 1.1 1 0 0 1 1 1 0 Hexon-associated protein (IIIa) ScpA_ScpB PF02616.9 KOO53080.1 - 2.4 7.6 7.6 0.13 11.7 1.7 1.4 2 0 0 2 2 2 0 ScpA/B protein PPR_2 PF13041.1 KOO53081.1 - 3.4e-72 238.2 0.1 6.3e-13 48.4 0.0 7.1 1 1 6 7 7 7 7 PPR repeat family PPR_3 PF13812.1 KOO53081.1 - 7e-52 169.3 6.2 3.7e-07 29.9 0.0 8.8 8 0 0 8 8 8 7 Pentatricopeptide repeat domain PPR PF01535.15 KOO53081.1 - 6.7e-45 147.9 5.7 1.9e-05 24.2 0.0 8.3 8 0 0 8 8 8 7 PPR repeat PPR_1 PF12854.2 KOO53081.1 - 1.1e-43 146.3 0.0 2.6e-05 23.6 0.0 8.3 8 0 0 8 8 8 8 PPR repeat PCIF1_WW PF12237.3 KOO53081.1 - 2.5e-29 101.8 0.3 5.6e-29 100.6 0.2 1.5 1 0 0 1 1 1 1 Phosphorylated CTD interacting factor 1 WW domain Dev_Cell_Death PF10539.4 KOO53081.1 - 6.1e-11 41.9 0.0 1.2e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 Development and cell death domain Clathrin PF00637.15 KOO53081.1 - 8.6e-05 22.1 0.0 0.032 13.8 0.0 3.4 3 1 2 5 5 5 2 Region in Clathrin and VPS Apc3 PF12895.2 KOO53081.1 - 0.00014 21.9 0.2 0.01 15.9 0.0 3.3 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 KOO53081.1 - 0.001 18.6 5.6 37 4.4 0.0 7.1 8 0 0 8 8 8 0 Tetratricopeptide repeat MRP-S27 PF10037.4 KOO53081.1 - 0.014 14.3 0.0 0.4 9.5 0.0 2.7 1 1 2 3 3 3 0 Mitochondrial 28S ribosomal protein S27 Ebola_NP PF05505.7 KOO53081.1 - 0.15 10.1 0.2 0.59 8.1 0.0 2.0 2 1 0 2 2 2 0 Ebola nucleoprotein TPR_16 PF13432.1 KOO53081.1 - 1.2 9.8 9.1 5.2 7.8 0.5 4.0 3 1 2 5 5 4 0 Tetratricopeptide repeat Ribosomal_L13e PF01294.13 KOO53083.1 - 6.3e-05 22.5 13.8 0.7 9.3 0.1 6.9 4 1 5 9 9 9 3 Ribosomal protein L13e TIR_2 PF13676.1 KOO53083.1 - 0.00012 22.1 0.1 0.00046 20.2 0.0 2.0 2 0 0 2 2 2 1 TIR domain SinI PF08671.5 KOO53083.1 - 0.0027 17.0 6.6 25 4.4 0.0 6.7 7 1 1 8 8 8 1 Anti-repressor SinI MerR_1 PF13411.1 KOO53083.1 - 0.0046 16.6 0.0 60 3.5 0.0 6.0 6 1 1 7 7 7 0 MerR HTH family regulatory protein DUF1373 PF07117.6 KOO53083.1 - 0.023 14.4 2.6 1.3 8.6 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1373) RPAP1_C PF08620.5 KOO53083.1 - 1.5 8.6 10.8 1.1e+02 2.7 0.0 7.1 7 3 2 9 9 9 0 RPAP1-like, C-terminal Syntaphilin PF15290.1 KOO53084.1 - 0.27 10.6 2.7 0.34 10.3 1.2 1.7 2 0 0 2 2 2 0 Golgi-localised syntaxin-1-binding clamp Herpes_BLRF2 PF05812.7 KOO53084.1 - 0.66 9.7 3.1 2.5 7.9 0.0 2.8 3 0 0 3 3 3 0 Herpesvirus BLRF2 protein DUF972 PF06156.8 KOO53084.1 - 1.8 8.9 3.7 1.9 8.8 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF972) TMF_DNA_bd PF12329.3 KOO53084.1 - 8.8 6.2 10.0 5.8 6.7 0.0 3.4 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding FHA PF00498.21 KOO53085.1 - 4.1e-17 62.0 0.4 6.1e-17 61.4 0.3 1.3 1 0 0 1 1 1 1 FHA domain OmpH PF03938.9 KOO53085.1 - 0.0034 17.3 0.4 0.0041 17.0 0.3 1.3 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) DUF904 PF06005.7 KOO53085.1 - 0.037 14.3 5.2 0.068 13.4 3.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF904) DUF4140 PF13600.1 KOO53085.1 - 5.3 7.5 7.5 1.3 9.4 1.6 2.3 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) RNase_H2-Ydr279 PF09468.5 KOO53086.1 - 2.4e-30 105.7 0.0 3.1e-30 105.4 0.0 1.1 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) CDC27 PF09507.5 KOO53086.1 - 0.6 9.2 5.3 0.4 9.8 2.6 1.4 1 1 1 2 2 2 0 DNA polymerase subunit Cdc27 PDZ PF00595.19 KOO53087.1 - 2.5e-41 139.7 1.1 3.5e-06 27.1 0.0 8.1 6 1 2 8 8 8 7 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO53087.1 - 1e-34 118.2 0.1 7.1e-05 22.6 0.0 8.4 5 2 3 8 8 8 7 PDZ domain EF-hand_5 PF13202.1 KOO53087.1 - 1.9e-18 64.8 1.3 0.00051 19.2 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_1 PF00036.27 KOO53087.1 - 3.3e-18 63.5 0.1 0.0016 17.6 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO53087.1 - 3.9e-18 63.6 0.2 0.0031 17.2 0.0 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO53087.1 - 5.7e-15 55.2 0.0 4.7e-05 23.4 0.0 3.9 3 1 1 4 4 4 4 EF-hand domain pair Tricorn_PDZ PF14685.1 KOO53087.1 - 1.5e-09 37.4 0.1 0.071 12.9 0.0 5.4 6 0 0 6 6 6 3 Tricorn protease PDZ domain EF-hand_8 PF13833.1 KOO53087.1 - 9.4e-07 28.3 0.2 0.37 10.4 0.0 4.3 4 0 0 4 4 4 2 EF-hand domain pair WD40 PF00400.27 KOO53087.1 - 0.0017 18.1 1.6 0.0084 15.9 0.2 2.5 2 0 0 2 2 2 1 WD domain, G-beta repeat DUF3640 PF12342.3 KOO53087.1 - 0.018 14.5 0.5 7.8 6.1 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3640) Imm42 PF15601.1 KOO53087.1 - 0.14 11.5 0.0 22 4.4 0.0 2.4 2 0 0 2 2 2 0 Immunity protein 42 Rieske PF00355.21 KOO53088.1 - 4.5e-14 51.7 0.0 1e-13 50.6 0.0 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain PaO PF08417.7 KOO53088.1 - 0.0042 16.9 0.0 0.0095 15.8 0.0 1.6 1 0 0 1 1 1 1 Pheophorbide a oxygenase IncA PF04156.9 KOO53089.1 - 0.019 14.6 1.3 0.019 14.6 0.9 2.2 2 0 0 2 2 2 0 IncA protein DUF605 PF04652.11 KOO53089.1 - 0.37 10.1 24.7 0.47 9.7 17.1 1.1 1 0 0 1 1 1 0 Vta1 like PAT1 PF09770.4 KOO53089.1 - 6.4 4.8 42.3 8.2 4.5 29.3 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PMSI1 PF15322.1 KOO53090.1 - 0.035 13.1 3.8 0.059 12.4 2.7 1.3 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative Syntaxin PF00804.20 KOO53091.1 - 0.021 14.9 4.6 0.67 10.1 0.2 3.2 3 1 0 3 3 3 0 Syntaxin IncA PF04156.9 KOO53091.1 - 0.15 11.5 14.6 0.05 13.2 1.6 2.3 2 0 0 2 2 2 0 IncA protein DUF972 PF06156.8 KOO53091.1 - 1.7 9.0 9.2 7.1 7.0 2.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF972) GAS PF13851.1 KOO53091.1 - 7.3 5.7 14.2 1.5 7.9 4.6 2.4 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding Atg14 PF10186.4 KOO53091.1 - 8.5 5.2 15.5 0.25 10.2 1.3 2.4 3 0 0 3 3 3 0 UV radiation resistance protein and autophagy-related subunit 14 Spc7 PF08317.6 KOO53091.1 - 9.4 4.7 8.8 5.7 5.4 1.7 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein MFS_1 PF07690.11 KOO53092.1 - 1.8e-14 53.2 47.6 6e-09 35.0 16.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily dCMP_cyt_deam_1 PF00383.17 KOO53093.1 - 1.5e-23 82.3 0.1 4e-23 80.9 0.0 1.6 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region AAA_25 PF13481.1 KOO53094.1 - 0.013 14.9 1.6 0.077 12.3 0.1 2.8 2 1 0 2 2 2 0 AAA domain PTCB-BRCT PF12738.2 KOO53095.1 - 1.4e-25 88.9 0.1 1.1e-11 44.4 0.0 3.2 3 0 0 3 3 3 3 twin BRCT domain BRCT PF00533.21 KOO53095.1 - 1.8e-20 72.8 0.0 1.9e-07 31.0 0.0 3.1 3 0 0 3 3 3 3 BRCA1 C Terminus (BRCT) domain TraC PF07820.7 KOO53095.1 - 0.1 12.8 0.0 1.8 8.8 0.0 2.3 2 0 0 2 2 2 0 TraC-like protein RNF111_N PF15303.1 KOO53096.1 - 0.47 9.9 14.4 0.56 9.6 10.0 1.1 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase Arkadia N-terminus SR-25 PF10500.4 KOO53096.1 - 2.2 7.7 22.9 3 7.2 15.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RNA_polI_A34 PF08208.6 KOO53096.1 - 6.7 6.3 21.6 6.8 6.3 15.0 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 SelP_N PF04592.9 KOO53096.1 - 9.7 5.4 12.4 10 5.4 8.6 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Chloroa_b-bind PF00504.16 KOO53097.1 - 2.5e-36 125.3 0.0 3e-36 125.0 0.0 1.1 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Dor1 PF04124.7 KOO53098.1 - 2.6e-45 154.3 0.0 3.5e-45 153.9 0.0 1.2 1 0 0 1 1 1 1 Dor1-like family Afi1 PF07792.7 KOO53099.1 - 1.9e-29 102.5 0.0 1.8e-28 99.3 0.0 2.2 1 1 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.5 KOO53099.1 - 6.6e-27 93.4 0.0 1e-26 92.8 0.0 1.3 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.4 KOO53099.1 - 3.8e-11 42.0 0.0 0.0048 15.4 0.0 3.2 2 1 1 3 3 3 3 Transport protein Avl9 DUF2347 PF09804.4 KOO53099.1 - 3.3e-08 33.1 0.0 1.5e-06 27.7 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2347) HEAT_2 PF13646.1 KOO53099.1 - 0.028 14.7 1.0 0.075 13.3 0.0 2.1 2 0 0 2 2 2 0 HEAT repeats zf-H2C2_2 PF13465.1 KOO53100.1 - 1.5e-22 78.6 22.3 9.4e-06 25.6 1.0 5.1 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.21 KOO53100.1 - 1e-13 50.7 23.0 0.00084 19.5 0.7 4.2 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOO53100.1 - 4.8e-09 35.9 20.9 0.02 15.1 0.4 4.2 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_5 PF13909.1 KOO53100.1 - 0.11 12.7 1.2 0.11 12.7 0.8 3.5 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.3 KOO53100.1 - 0.63 10.2 4.9 21 5.3 0.2 3.1 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 KOO53100.1 - 2 8.4 7.0 43 4.2 0.2 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-met PF12874.2 KOO53100.1 - 6.8 7.0 8.0 27 5.1 0.1 3.3 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Chromo PF00385.19 KOO53104.1 - 1.9e-10 40.2 3.0 6e-10 38.6 0.9 2.1 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain GSK-3_bind PF05350.7 KOO53106.1 - 0.078 12.4 4.1 0.14 11.5 2.8 1.4 1 0 0 1 1 1 0 Glycogen synthase kinase-3 binding Methyltransf_21 PF05050.7 KOO53107.1 - 3.7e-06 26.9 0.0 5e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase FkbM domain RRM_6 PF14259.1 KOO53108.1 - 3.6e-06 26.8 0.0 0.0033 17.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 KOO53108.1 - 3.8e-06 26.4 0.0 0.00061 19.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO53108.1 - 0.0041 16.9 0.1 0.56 10.0 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 KOO53108.1 - 0.067 12.9 0.0 0.21 11.3 0.0 1.8 1 0 0 1 1 1 0 Limkain b1 TIR_2 PF13676.1 KOO53109.1 - 4.8e-05 23.4 0.0 6.5e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 TIR domain TIR PF01582.15 KOO53109.1 - 0.0076 15.6 0.0 0.0096 15.3 0.0 1.2 1 0 0 1 1 1 1 TIR domain Radical_SAM PF04055.16 KOO53110.1 - 3.1e-12 46.9 0.0 6.9e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.1 KOO53110.1 - 0.00034 20.6 0.0 0.00072 19.5 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.1 KOO53110.1 - 0.0089 16.1 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain SPOR PF05036.8 KOO53110.1 - 0.0099 16.0 3.4 20 5.4 0.0 3.9 4 0 0 4 4 4 1 Sporulation related domain DUF1690 PF07956.6 KOO53110.1 - 0.13 12.2 0.2 0.28 11.1 0.0 1.6 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) Acetyltransf_7 PF13508.1 KOO53111.1 - 0.00062 19.8 0.0 0.001 19.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain EF-hand_7 PF13499.1 KOO53112.1 - 2.1e-13 50.1 0.8 3.6e-13 49.4 0.6 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO53112.1 - 5.3e-12 44.1 2.0 7.1e-07 28.0 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO53112.1 - 5.1e-09 35.2 0.4 6.7e-06 25.5 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO53112.1 - 2.9e-07 29.9 2.0 2.1e-05 24.0 0.4 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO53112.1 - 9.1e-07 27.9 1.1 0.00013 21.1 0.0 2.5 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.4 KOO53112.1 - 0.0017 18.3 0.0 0.01 15.8 0.0 2.0 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO53112.1 - 0.018 14.7 0.2 1.3 8.7 0.1 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand C2 PF00168.25 KOO53113.1 - 1.2e-10 41.1 0.0 2.3e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 C2 domain Lipoxygenase PF00305.14 KOO53113.1 - 3.6e-08 31.8 0.0 2.8e-07 28.9 0.0 1.9 2 0 0 2 2 2 1 Lipoxygenase Phage_integrase PF00589.17 KOO53114.1 - 2.2e-06 27.4 0.0 6.2e-06 25.9 0.0 1.7 2 0 0 2 2 2 1 Phage integrase family UAA PF08449.6 KOO53115.1 - 0.0064 15.4 24.5 0.011 14.7 17.0 1.4 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.15 KOO53115.1 - 0.012 15.6 27.1 0.065 13.2 7.7 2.8 2 1 0 2 2 2 0 EamA-like transporter family ESSS PF10183.4 KOO53115.1 - 5.7 7.3 6.0 0.75 10.2 0.4 2.4 2 0 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) TPT PF03151.11 KOO53116.1 - 1.3e-09 37.8 7.3 1.9e-09 37.3 5.1 1.3 1 0 0 1 1 1 1 Triose-phosphate Transporter family EmrE PF13536.1 KOO53116.1 - 0.0083 16.3 10.3 0.0083 16.3 7.2 2.5 1 1 2 3 3 3 1 Multidrug resistance efflux transporter EamA PF00892.15 KOO53116.1 - 0.12 12.4 18.0 0.046 13.7 8.5 2.6 1 1 2 3 3 3 0 EamA-like transporter family ExoD PF06055.7 KOO53117.1 - 0.28 10.2 3.9 0.35 9.9 2.7 1.1 1 0 0 1 1 1 0 Exopolysaccharide synthesis, ExoD DUF972 PF06156.8 KOO53118.1 - 0.022 15.0 1.9 0.022 15.0 1.3 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF972) HALZ PF02183.13 KOO53118.1 - 0.45 10.2 5.8 0.42 10.3 0.3 3.5 3 0 0 3 3 3 0 Homeobox associated leucine zipper YwqJ-deaminase PF14431.1 KOO53118.1 - 0.52 10.1 4.5 0.25 11.2 0.6 2.1 2 0 0 2 2 2 0 YwqJ-like deaminase YbjQ_1 PF01906.12 KOO53118.1 - 3.5 8.0 6.4 0.33 11.4 0.6 2.2 2 2 1 3 3 3 0 Putative heavy-metal-binding Sigma70_ner PF04546.8 KOO53118.1 - 7.8 6.0 16.4 0.73 9.4 6.4 2.5 1 1 1 3 3 3 0 Sigma-70, non-essential region Inhibitor_Mig-6 PF11555.3 KOO53120.1 - 0.022 15.1 0.3 0.032 14.6 0.2 1.4 1 1 0 1 1 1 0 EGFR receptor inhibitor Mig-6 DUF4281 PF14108.1 KOO53121.1 - 5e-32 110.7 1.0 5e-32 110.7 0.7 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4281) Ion_trans PF00520.26 KOO53121.1 - 6.4e-21 74.5 5.9 1.3e-20 73.5 4.1 1.5 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO53121.1 - 4.6e-07 29.4 1.3 4.6e-07 29.4 0.9 2.1 2 0 0 2 2 2 1 Ion channel F-box-like PF12937.2 KOO53122.1 - 0.47 10.2 3.9 1.7 8.4 2.7 1.8 1 1 0 1 1 1 0 F-box-like EF-hand_8 PF13833.1 KOO53123.1 - 2.3e-17 62.3 1.2 1.4e-07 30.9 0.1 3.7 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.1 KOO53123.1 - 6.6e-17 59.8 6.8 0.0017 18.0 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.27 KOO53123.1 - 2.8e-15 54.3 10.7 0.0005 19.1 0.3 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO53123.1 - 6e-15 55.1 0.5 1.5e-06 28.2 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO53123.1 - 1.8e-13 49.1 11.2 0.005 16.1 0.4 4.4 4 0 0 4 4 4 4 EF hand SPARC_Ca_bdg PF10591.4 KOO53123.1 - 0.008 16.2 0.0 1.6 8.7 0.0 2.7 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region adh_short PF00106.20 KOO53124.1 - 7.8e-08 32.4 0.6 1.4e-07 31.5 0.1 1.7 2 0 0 2 2 2 1 short chain dehydrogenase DUF1501 PF07394.7 KOO53125.1 - 1.2e-39 136.3 0.0 2e-39 135.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1501) DUF1800 PF08811.6 KOO53125.1 - 5.8e-07 28.8 0.0 8.6e-07 28.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1800) Pkinase PF00069.20 KOO53126.1 - 0.00019 20.6 0.0 0.00029 20.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APC8 PF04049.8 KOO53128.1 - 5.8e-30 103.8 0.0 4.4e-29 101.0 0.0 2.2 2 0 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_11 PF13414.1 KOO53128.1 - 4e-20 71.2 21.8 1.7e-09 37.2 0.9 6.1 5 1 1 6 6 6 3 TPR repeat TPR_2 PF07719.12 KOO53128.1 - 8.9e-17 59.5 25.6 0.0038 17.0 0.0 8.9 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_14 PF13428.1 KOO53128.1 - 6.4e-16 57.4 21.3 0.00074 19.9 0.0 9.1 7 3 2 9 9 8 5 Tetratricopeptide repeat TPR_1 PF00515.23 KOO53128.1 - 9.8e-16 56.6 20.8 6.5e-05 22.3 0.0 7.0 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO53128.1 - 1.7e-12 46.1 5.4 0.011 15.4 0.0 6.3 6 1 1 7 7 6 3 Tetratricopeptide repeat TPR_16 PF13432.1 KOO53128.1 - 5.7e-12 45.9 30.8 2.8e-06 27.8 1.0 7.2 5 3 2 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOO53128.1 - 1.1e-09 38.4 20.7 0.0077 16.5 1.2 5.6 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 KOO53128.1 - 1.9e-07 30.7 11.1 0.015 15.4 0.2 6.8 7 1 1 8 8 7 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO53128.1 - 2.5e-07 30.5 21.0 0.00029 20.7 0.2 6.1 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO53128.1 - 5.2e-05 22.7 16.9 0.094 12.5 0.0 8.0 8 1 1 9 9 9 1 Tetratricopeptide repeat Apc3 PF12895.2 KOO53128.1 - 0.0069 16.4 25.2 0.064 13.3 0.0 5.9 3 2 1 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 KOO53128.1 - 0.012 16.0 21.1 39 5.0 0.0 8.4 7 1 0 7 7 7 0 Tetratricopeptide repeat ChAPs PF09295.5 KOO53128.1 - 0.027 13.2 0.0 0.048 12.4 0.0 1.3 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_9 PF13371.1 KOO53128.1 - 0.057 13.2 6.6 5 7.0 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.1 KOO53128.1 - 1.2 9.1 7.3 31 4.6 0.1 4.9 6 0 0 6 6 5 0 Tetratricopeptide repeat PSII PF00421.14 KOO53130.1 - 0.01 14.4 0.1 0.011 14.3 0.1 1.0 1 0 0 1 1 1 0 Photosystem II protein Herpes_UL42 PF02282.11 KOO53131.1 - 0.072 12.6 0.3 0.2 11.2 0.1 1.7 2 0 0 2 2 2 0 DNA polymerase processivity factor (UL42) EF-hand_6 PF13405.1 KOO53133.1 - 3e-33 110.6 18.0 3.8e-05 23.2 0.1 11.9 12 0 0 12 12 12 6 EF-hand domain EF-hand_1 PF00036.27 KOO53133.1 - 1.3e-31 105.4 22.4 1.7e-05 23.7 0.1 10.0 10 0 0 10 10 10 7 EF hand EF-hand_7 PF13499.1 KOO53133.1 - 4.1e-29 100.5 22.6 1.6e-06 28.1 1.2 10.3 6 3 2 9 9 9 6 EF-hand domain pair EF-hand_8 PF13833.1 KOO53133.1 - 3.9e-18 64.8 37.0 0.00026 20.5 0.3 9.6 7 3 2 9 9 9 7 EF-hand domain pair EF-hand_5 PF13202.1 KOO53133.1 - 1.8e-14 52.2 19.8 0.0066 15.7 0.1 7.8 7 0 0 7 7 7 4 EF hand EF-hand_4 PF12763.2 KOO53133.1 - 0.00026 20.6 17.5 0.26 11.0 0.1 6.5 5 2 1 6 6 6 3 Cytoskeletal-regulatory complex EF hand DUF960 PF06124.6 KOO53133.1 - 0.0041 17.3 0.7 16 5.8 0.0 4.8 5 0 0 5 5 5 0 Staphylococcal protein of unknown function (DUF960) SHIPPO-rpt PF07004.7 KOO53133.1 - 0.0047 17.7 19.1 0.24 12.3 0.0 6.3 6 1 0 6 6 6 2 Sperm-tail PG-rich repeat DUF4473 PF14747.1 KOO53133.1 - 0.017 15.2 0.4 0.49 10.6 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4473) Fmp27_GFWDK PF10347.4 KOO53133.1 - 0.048 13.6 1.6 14 5.5 0.0 3.3 3 0 0 3 3 3 0 RNA pol II promoter Fmp27 protein domain Endonuc-dimeris PF09124.5 KOO53133.1 - 0.24 11.0 9.5 1.3 8.7 0.0 4.3 5 0 0 5 5 5 0 T4 recombination endonuclease VII, dimerisation EF-hand_10 PF14788.1 KOO53133.1 - 0.86 9.3 13.3 13 5.5 0.0 5.9 5 3 3 8 8 8 0 EF hand DSPc PF00782.15 KOO53134.1 - 7.7e-08 32.0 0.0 2e-07 30.6 0.0 1.5 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTEN_C2 PF10409.4 KOO53134.1 - 1.8e-07 30.9 0.0 0.00071 19.3 0.0 2.3 2 0 0 2 2 2 2 C2 domain of PTEN tumour-suppressor protein Ion_trans PF00520.26 KOO53134.1 - 0.00013 21.3 3.9 0.0002 20.6 2.7 1.2 1 0 0 1 1 1 1 Ion transport protein Y_phosphatase PF00102.22 KOO53134.1 - 0.00049 19.5 0.1 0.0023 17.3 0.0 1.9 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 KOO53134.1 - 0.0021 18.1 0.0 0.0041 17.1 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate Aminotran_4 PF01063.14 KOO53134.1 - 0.14 11.6 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class IV Glycos_transf_2 PF00535.21 KOO53136.1 - 6e-31 107.3 0.0 7.7e-31 107.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 KOO53136.1 - 1.7e-15 57.4 0.0 2.3e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 KOO53136.1 - 2e-05 23.9 0.0 3.2e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.4 KOO53136.1 - 0.00044 19.4 0.0 0.00058 19.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.1 KOO53136.1 - 0.063 13.5 0.0 0.39 11.0 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 2 Phage_integrase PF00589.17 KOO53137.1 - 6.5e-05 22.6 0.0 0.00019 21.1 0.0 1.8 1 1 0 1 1 1 1 Phage integrase family HTH_37 PF13744.1 KOO53137.1 - 0.016 14.9 0.0 0.037 13.8 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain C2 PF00168.25 KOO53138.1 - 9.9e-11 41.3 0.0 2.2e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 C2 domain P2X_receptor PF00864.14 KOO53138.1 - 0.15 10.7 0.1 0.24 10.0 0.1 1.2 1 0 0 1 1 1 0 ATP P2X receptor Phage_B PF02304.10 KOO53138.1 - 1.6 9.0 3.7 2.1 8.6 0.4 2.2 2 0 0 2 2 2 0 Scaffold protein B DUF4326 PF14216.1 KOO53139.1 - 1.9e-06 28.3 1.5 1e-05 25.9 0.2 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF4326) CART PF06373.6 KOO53139.1 - 0.07 13.0 0.9 0.23 11.4 0.3 2.1 2 0 0 2 2 2 0 Cocaine and amphetamine regulated transcript protein (CART) Metal_resist PF13801.1 KOO53140.1 - 0.042 13.8 16.0 0.076 13.0 11.1 1.3 1 0 0 1 1 1 0 Heavy-metal resistance REV PF00424.13 KOO53140.1 - 0.077 12.8 1.0 0.12 12.3 0.7 1.4 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) DUF3138 PF11336.3 KOO53140.1 - 0.64 8.1 2.7 0.65 8.0 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF1425 PF07233.7 KOO53141.1 - 0.00044 19.7 0.0 1 8.9 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1425) DUF4124 PF13511.1 KOO53141.1 - 0.0062 16.5 1.7 2.8 8.0 0.6 3.3 2 1 0 2 2 2 2 Domain of unknown function (DUF4124) Arm PF00514.18 KOO53143.1 - 1.4e-58 192.8 36.1 1.4e-08 34.2 0.3 9.6 9 0 0 9 9 9 9 Armadillo/beta-catenin-like repeat DNA_ligase_OB PF03120.11 KOO53143.1 - 3.9e-11 42.4 3.6 2 8.1 0.0 8.7 2 1 7 9 9 9 1 NAD-dependent DNA ligase OB-fold domain Arm_2 PF04826.8 KOO53143.1 - 1.8e-07 30.5 4.9 0.11 11.5 0.2 4.0 1 1 3 4 4 4 3 Armadillo-like RPAP1_C PF08620.5 KOO53143.1 - 3.9e-06 26.6 0.6 69 3.4 0.0 6.8 7 0 0 7 7 7 0 RPAP1-like, C-terminal Peptidase_S41 PF03572.13 KOO53143.1 - 8.9e-05 21.9 4.2 5.1 6.4 0.0 5.1 1 1 3 4 4 4 2 Peptidase family S41 HEAT_2 PF13646.1 KOO53143.1 - 0.0017 18.6 40.7 0.0082 16.3 3.0 4.7 1 1 2 4 4 4 3 HEAT repeats DUF383 PF04063.9 KOO53143.1 - 0.027 14.0 0.0 17 4.8 0.0 3.3 1 1 1 2 2 2 0 Domain of unknown function (DUF383) ACC_central PF08326.7 KOO53143.1 - 0.044 11.8 0.4 13 3.7 0.0 3.6 3 1 0 4 4 4 0 Acetyl-CoA carboxylase, central region HEAT_EZ PF13513.1 KOO53143.1 - 0.067 13.6 36.3 0.08 13.4 3.0 6.3 1 1 7 8 8 8 0 HEAT-like repeat DUF1676 PF07898.8 KOO53143.1 - 0.082 13.2 0.4 1.4e+02 2.8 0.0 4.9 1 1 6 7 7 7 0 Protein of unknown function (DUF1676) SPOUT_MTase PF02590.12 KOO53143.1 - 0.11 12.2 8.5 15 5.2 0.2 3.9 1 1 1 3 3 3 0 Predicted SPOUT methyltransferase KAP PF05804.7 KOO53143.1 - 0.16 9.8 0.0 0.66 7.8 0.0 1.9 1 1 0 1 1 1 0 Kinesin-associated protein (KAP) CRAL_TRIO PF00650.15 KOO53145.1 - 0.016 14.6 0.0 0.026 13.9 0.0 1.2 1 0 0 1 1 1 0 CRAL/TRIO domain Mod_r PF07200.8 KOO53146.1 - 0.017 15.0 1.3 0.017 15.0 0.9 4.3 4 1 0 4 4 4 0 Modifier of rudimentary (Mod(r)) protein Nup54 PF13874.1 KOO53146.1 - 0.36 10.4 13.0 1.7 8.3 0.2 3.8 2 1 1 3 3 3 0 Nucleoporin complex subunit 54 Spc7 PF08317.6 KOO53146.1 - 1.9 7.0 24.7 0.088 11.4 5.4 3.2 3 1 1 4 4 4 0 Spc7 kinetochore protein KxDL PF10241.4 KOO53146.1 - 2.3 8.1 8.9 2.4 8.1 1.3 3.0 2 1 0 2 2 2 0 Uncharacterized conserved protein Reo_sigmaC PF04582.7 KOO53146.1 - 2.6 7.1 5.8 7.2 5.6 0.6 2.3 2 0 0 2 2 2 0 Reovirus sigma C capsid protein DUF16 PF01519.11 KOO53146.1 - 4.6 7.5 8.1 2.7e+02 1.8 5.6 3.0 1 1 0 1 1 1 0 Protein of unknown function DUF16 DUF972 PF06156.8 KOO53146.1 - 9.6 6.6 17.8 0.32 11.3 0.3 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF972) Ribosomal_L9_C PF03948.9 KOO53148.1 - 1.5e-19 69.8 4.1 2.2e-19 69.3 0.9 2.1 2 0 0 2 2 2 1 Ribosomal protein L9, C-terminal domain Ribosomal_L9_N PF01281.14 KOO53148.1 - 7.1e-10 37.9 0.4 1.7e-09 36.7 0.3 1.7 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain NodZ PF05830.6 KOO53149.1 - 0.00026 19.6 0.0 0.00042 19.0 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein Z (NodZ) DUF2390 PF09523.5 KOO53149.1 - 0.065 13.4 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2390) Tubulin PF00091.20 KOO53150.1 - 3.5e-33 115.2 2.3 1.7e-32 113.0 1.6 2.0 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain FtsZ_C PF12327.3 KOO53150.1 - 1.3e-30 105.3 0.2 3.7e-30 103.8 0.1 1.9 1 0 0 1 1 1 1 FtsZ family, C-terminal domain PTE PF02126.13 KOO53150.1 - 0.033 13.1 0.2 0.057 12.4 0.2 1.3 1 0 0 1 1 1 0 Phosphotriesterase family Tubulin_2 PF13809.1 KOO53150.1 - 2 7.2 11.0 15 4.4 0.1 2.8 1 1 1 2 2 2 0 Tubulin like Dpy-30 PF05186.8 KOO53151.1 - 3.4e-05 23.2 0.1 6.6e-05 22.2 0.1 1.5 1 0 0 1 1 1 1 Dpy-30 motif SUI1 PF01253.17 KOO53152.1 - 2e-10 40.3 0.0 3.4e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 Translation initiation factor SUI1 Img2 PF05046.9 KOO53152.1 - 3.9e-06 26.9 0.0 1.2e-05 25.3 0.0 1.8 1 1 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) NP1-WLL PF11733.3 KOO53153.1 - 0.26 11.5 3.9 0.3 11.3 2.7 1.1 1 0 0 1 1 1 0 Non-capsid protein NP1 FWWh PF14922.1 KOO53154.1 - 1.3e-06 27.9 0.0 2e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function FGE-sulfatase PF03781.11 KOO53155.1 - 3.7e-32 111.7 2.2 3.7e-32 111.7 1.5 1.8 2 0 0 2 2 2 1 Sulfatase-modifying factor enzyme 1 Arm PF00514.18 KOO53156.1 - 3.8e-11 42.3 3.3 0.00084 19.0 0.3 3.7 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO53156.1 - 1.9e-05 24.8 7.7 0.0065 16.7 0.1 3.4 2 2 1 3 3 3 2 HEAT repeats HEAT PF02985.17 KOO53156.1 - 0.00024 20.9 2.5 0.44 10.7 0.0 4.4 4 0 0 4 4 4 1 HEAT repeat Arm_2 PF04826.8 KOO53156.1 - 0.096 11.7 0.0 1.4 7.9 0.0 2.2 2 0 0 2 2 2 0 Armadillo-like RasGEF_N_2 PF14663.1 KOO53156.1 - 0.12 12.2 0.2 5.6 6.9 0.0 2.4 1 1 1 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain EF-hand_1 PF00036.27 KOO53157.1 - 9e-14 49.6 1.4 2.9e-06 26.1 0.3 2.7 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.1 KOO53157.1 - 1.1e-10 40.2 0.7 0.00024 20.3 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO53157.1 - 4.6e-10 39.5 0.4 1.3e-09 38.0 0.3 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO53157.1 - 6.5e-09 34.9 0.1 0.0066 16.2 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 KOO53157.1 - 9.7e-05 21.9 1.7 0.0015 18.1 0.3 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.2 KOO53157.1 - 0.0064 16.2 0.0 0.0064 16.2 0.0 1.7 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand Ank_2 PF12796.2 KOO53157.1 - 0.014 15.7 0.0 0.041 14.2 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) EF-hand_9 PF14658.1 KOO53157.1 - 0.038 13.9 0.2 0.1 12.5 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain IQ PF00612.22 KOO53157.1 - 0.13 11.9 9.9 5.8 6.8 0.9 3.8 3 0 0 3 3 3 0 IQ calmodulin-binding motif SPARC_Ca_bdg PF10591.4 KOO53157.1 - 0.16 11.9 0.0 0.58 10.2 0.0 1.9 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_1 PF00036.27 KOO53158.1 - 1.6e-23 80.1 11.8 1.1e-08 33.7 0.0 3.1 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.1 KOO53158.1 - 7.1e-18 64.5 7.0 9.2e-16 57.7 0.9 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO53158.1 - 7.7e-18 63.8 8.0 1.5e-12 46.9 0.2 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO53158.1 - 6.3e-17 60.0 6.0 2e-07 29.9 0.1 3.3 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO53158.1 - 2.5e-16 57.9 5.2 1.9e-07 30.4 0.0 3.2 3 0 0 3 3 3 3 EF-hand domain EF-hand_9 PF14658.1 KOO53158.1 - 0.00032 20.5 1.2 0.012 15.5 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO53158.1 - 0.0012 18.8 2.4 0.69 9.9 0.0 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region SPK PF04435.13 KOO53158.1 - 0.11 12.4 0.0 0.17 11.8 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF545) EF-hand_10 PF14788.1 KOO53158.1 - 0.25 11.0 1.9 7.3 6.3 0.1 3.0 3 0 0 3 3 3 0 EF hand EF-hand_4 PF12763.2 KOO53158.1 - 0.38 10.5 4.1 3.4 7.4 0.5 2.6 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand LRR_6 PF13516.1 KOO53159.1 - 1.4e-16 58.6 2.5 2.1e-05 24.1 0.1 4.5 4 1 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.2 KOO53159.1 - 1.7e-11 43.4 6.8 4.5e-05 22.9 0.0 3.0 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO53159.1 - 0.0028 17.3 0.7 0.22 11.2 0.5 2.6 1 1 2 3 3 3 3 Leucine rich repeat LRR_7 PF13504.1 KOO53159.1 - 0.018 15.1 0.1 33 5.3 0.0 3.5 3 0 0 3 3 3 0 Leucine rich repeat UIM PF02809.15 KOO53159.1 - 0.04 13.4 4.2 15 5.4 0.1 3.5 3 0 0 3 3 3 0 Ubiquitin interaction motif LRR_1 PF00560.28 KOO53159.1 - 0.077 13.0 0.0 37 4.8 0.0 3.4 4 0 0 4 4 4 0 Leucine Rich Repeat RabGAP-TBC PF00566.13 KOO53160.1 - 1.9e-16 60.1 0.1 2.5e-16 59.8 0.1 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Sec7 PF01369.15 KOO53161.1 - 7.2e-14 51.9 0.0 1.1e-13 51.2 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain Nop14 PF04147.7 KOO53161.1 - 0.047 11.6 0.3 0.053 11.4 0.2 1.1 1 0 0 1 1 1 0 Nop14-like family Sigma70_ner PF04546.8 KOO53161.1 - 1.2 8.7 5.3 1.8 8.1 3.6 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF1800 PF08811.6 KOO53162.1 - 3.5e-30 105.3 0.1 5.3e-30 104.7 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1800) Gly_transf_sug PF04488.10 KOO53165.1 - 1.9e-11 44.2 0.0 6.6e-11 42.5 0.0 2.0 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Tim44 PF04280.10 KOO53167.1 - 1.3e-22 80.3 1.2 2.1e-22 79.6 0.0 1.8 2 0 0 2 2 2 1 Tim44-like domain DUF2413 PF10310.4 KOO53167.1 - 0.26 10.0 11.9 0.38 9.5 8.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2413) MT0933_antitox PF14013.1 KOO53167.1 - 1.4 9.0 8.2 5.4 7.2 5.5 2.2 2 1 0 2 2 2 0 MT0933-like antitoxin protein DUF572 PF04502.8 KOO53167.1 - 1.5 7.9 8.0 2.2 7.4 5.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Macoilin PF09726.4 KOO53167.1 - 1.5 6.9 10.6 2.1 6.5 7.4 1.1 1 0 0 1 1 1 0 Transmembrane protein TraG_N PF07916.6 KOO53167.1 - 4.1 5.7 7.6 16 3.7 3.8 2.0 2 0 0 2 2 2 0 TraG-like protein, N-terminal region DUF972 PF06156.8 KOO53167.1 - 9.4 6.6 6.1 25 5.2 4.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF972) EF-hand_1 PF00036.27 KOO53168.1 - 0.00016 20.7 0.2 0.00036 19.6 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.1 KOO53168.1 - 0.0035 16.6 0.1 0.0084 15.4 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.1 KOO53168.1 - 0.0039 16.7 0.1 0.0077 15.8 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.1 KOO53168.1 - 0.02 14.9 0.0 0.045 13.8 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.1 KOO53168.1 - 0.069 13.0 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain Nsp1_C PF05064.8 KOO53169.1 - 7e-10 38.5 0.6 1.5e-09 37.4 0.1 1.8 2 0 0 2 2 2 1 Nsp1-like C-terminal region HOOK PF05622.7 KOO53169.1 - 0.014 13.2 3.2 0.018 12.8 2.2 1.1 1 0 0 1 1 1 0 HOOK protein Dor1 PF04124.7 KOO53169.1 - 0.052 11.9 1.0 0.089 11.2 0.7 1.3 1 0 0 1 1 1 0 Dor1-like family CheZ PF04344.8 KOO53169.1 - 0.056 13.1 2.6 0.088 12.4 1.8 1.4 1 0 0 1 1 1 0 Chemotaxis phosphatase, CheZ V_ATPase_I PF01496.14 KOO53169.1 - 0.079 10.8 0.3 0.099 10.4 0.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1465 PF07323.7 KOO53169.1 - 0.15 11.6 3.3 0.27 10.8 1.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1465) CorA PF01544.13 KOO53169.1 - 1.4 7.9 8.2 0.74 8.7 1.4 2.3 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Chalcone PF02431.10 KOO53171.1 - 1.8e-11 43.8 0.0 2.4e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 Chalcone-flavanone isomerase EF-hand_1 PF00036.27 KOO53172.1 - 7.9e-13 46.7 0.8 1.5e-05 23.9 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO53172.1 - 2.7e-11 42.9 6.8 5.8e-06 25.8 0.2 2.9 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO53172.1 - 3.1e-10 38.9 0.1 0.00011 21.4 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO53172.1 - 3.5e-09 35.7 1.4 0.0034 17.1 0.0 3.0 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.1 KOO53172.1 - 1e-08 35.1 1.5 1.7e-08 34.4 0.2 1.9 2 0 0 2 2 2 1 EF-hand domain pair HTH_24 PF13412.1 KOO53172.1 - 0.011 15.0 0.0 0.033 13.5 0.0 1.9 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding zf-DNA_Pol PF08996.5 KOO53172.1 - 0.028 13.7 0.1 0.036 13.4 0.1 1.1 1 0 0 1 1 1 0 DNA Polymerase alpha zinc finger Sigma70_r4 PF04545.11 KOO53172.1 - 0.043 13.1 0.1 2.9 7.2 0.0 2.7 2 0 0 2 2 2 0 Sigma-70, region 4 Mei5 PF10376.4 KOO53172.1 - 0.062 12.8 0.3 7.3 6.0 0.0 2.2 2 0 0 2 2 2 0 Double-strand recombination repair protein Cleaved_Adhesin PF07675.6 KOO53172.1 - 0.067 12.7 1.4 0.43 10.1 0.1 2.2 1 1 1 2 2 2 0 Cleaved Adhesin Domain EF-hand_4 PF12763.2 KOO53172.1 - 0.088 12.5 0.9 2.9 7.6 0.0 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand ECH PF00378.15 KOO53173.1 - 7.1e-07 28.5 0.3 1.2e-06 27.8 0.2 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family TPR_19 PF14559.1 KOO53173.1 - 5.2e-06 26.7 6.4 0.04 14.2 0.3 4.2 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO53173.1 - 7.4e-06 25.5 6.4 0.0075 15.9 0.0 4.0 3 1 0 3 3 3 2 TPR repeat TPR_2 PF07719.12 KOO53173.1 - 4.1e-05 23.1 0.2 4.1e-05 23.1 0.2 4.1 5 0 0 5 5 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 KOO53173.1 - 6.9e-05 22.2 0.0 0.00079 18.9 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 KOO53173.1 - 0.0012 18.9 1.9 0.98 9.5 0.1 3.3 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.1 KOO53173.1 - 0.0013 18.6 5.0 0.0015 18.3 0.1 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.1 KOO53173.1 - 0.002 17.2 0.8 0.063 12.3 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 KOO53173.1 - 0.0022 18.6 0.2 0.0022 18.6 0.1 5.5 5 1 1 6 6 5 2 Tetratricopeptide repeat TPR_7 PF13176.1 KOO53173.1 - 0.004 16.8 2.3 0.047 13.4 0.1 2.9 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.1 KOO53173.1 - 0.019 14.8 0.2 0.019 14.8 0.1 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO53173.1 - 0.021 15.4 0.2 0.021 15.4 0.1 5.7 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO53173.1 - 0.058 13.8 0.1 0.058 13.8 0.1 3.4 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_17 PF13431.1 KOO53173.1 - 0.068 13.4 1.0 38 4.8 0.0 3.8 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 KOO53173.1 - 0.11 12.3 0.0 0.4 10.5 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat CDC45 PF02724.9 KOO53173.1 - 0.13 10.2 4.7 0.18 9.8 3.3 1.1 1 0 0 1 1 1 0 CDC45-like protein TPR_4 PF07721.9 KOO53173.1 - 0.51 10.9 13.3 0.53 10.8 0.0 4.5 4 0 0 4 4 3 0 Tetratricopeptide repeat Cwf_Cwc_15 PF04889.7 KOO53173.1 - 8.1 6.0 8.2 13 5.4 5.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein UPF0449 PF15136.1 KOO53174.1 - 0.015 15.4 0.1 6.7 6.9 0.1 3.1 3 0 0 3 3 3 0 Uncharacterised protein family UPF0449 PAT1 PF09770.4 KOO53174.1 - 1.9 6.6 6.7 2.7 6.1 4.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SlyX PF04102.7 KOO53174.1 - 2.2 8.6 10.4 4.8 7.6 4.5 2.8 2 0 0 2 2 2 0 SlyX COesterase PF00135.23 KOO53177.1 - 6.4e-38 130.7 0.0 1.8e-37 129.2 0.0 1.6 2 0 0 2 2 2 1 Carboxylesterase family Abhydrolase_3 PF07859.8 KOO53177.1 - 0.00012 21.7 0.2 0.00088 18.9 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 KOO53177.1 - 0.033 13.4 0.1 0.08 12.1 0.1 1.6 1 1 0 1 1 1 0 Prolyl oligopeptidase family Saccharop_dh PF03435.13 KOO53178.1 - 7.2e-09 35.0 0.0 1.1e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase AAA PF00004.24 KOO53179.1 - 2e-13 50.6 0.0 3.6e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOO53179.1 - 0.0017 18.4 1.1 1.7 8.7 0.2 2.6 1 1 1 2 2 2 2 AAA domain AAA_5 PF07728.9 KOO53179.1 - 0.0053 16.4 0.1 0.016 14.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 KOO53179.1 - 0.0082 15.3 0.4 0.051 12.7 0.2 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 KOO53179.1 - 0.0089 15.7 0.3 0.03 14.0 0.2 1.9 1 0 0 1 1 1 1 Part of AAA domain ArgK PF03308.11 KOO53179.1 - 0.013 14.3 0.5 0.033 12.9 0.2 1.7 1 1 1 2 2 2 0 ArgK protein NTPase_1 PF03266.10 KOO53179.1 - 0.016 14.9 0.3 0.035 13.8 0.2 1.6 1 0 0 1 1 1 0 NTPase DUF2075 PF09848.4 KOO53179.1 - 0.022 13.7 0.7 0.27 10.1 0.5 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_28 PF13521.1 KOO53179.1 - 0.037 14.0 0.5 0.12 12.3 0.1 2.0 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 KOO53179.1 - 0.037 13.7 0.3 3.5 7.3 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 KOO53179.1 - 0.041 13.7 0.1 0.11 12.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 KOO53179.1 - 0.046 14.5 5.4 0.075 13.8 1.9 2.5 2 1 0 2 2 2 0 AAA domain ResIII PF04851.10 KOO53179.1 - 0.047 13.5 0.1 0.22 11.3 0.0 1.8 1 1 0 2 2 2 0 Type III restriction enzyme, res subunit Zot PF05707.7 KOO53179.1 - 0.051 13.0 0.1 1.5 8.2 0.1 2.3 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) TrwB_AAD_bind PF10412.4 KOO53179.1 - 0.052 12.1 0.1 0.097 11.2 0.1 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain KTI12 PF08433.5 KOO53179.1 - 0.066 12.4 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_18 PF13238.1 KOO53179.1 - 0.1 12.9 2.5 0.1 12.9 0.2 2.2 2 1 0 2 2 2 0 AAA domain ISN1 PF06437.6 KOO53179.1 - 0.11 11.2 0.6 0.36 9.4 0.0 1.8 1 1 1 2 2 2 0 IMP-specific 5'-nucleotidase AAA_25 PF13481.1 KOO53179.1 - 0.12 11.7 0.0 0.27 10.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain NAD_binding_1 PF00175.16 KOO53180.1 - 1.6e-13 51.1 0.1 1e-10 42.1 0.0 2.3 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 KOO53180.1 - 0.00036 20.5 0.0 0.00058 19.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 KOO53180.1 - 0.0019 18.1 0.0 0.19 11.6 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain RVT_2 PF07727.9 KOO53181.1 - 0.00037 19.5 0.0 0.0022 16.9 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Guanylate_cyc PF00211.15 KOO53182.1 - 3.1e-45 153.8 0.0 4.3e-45 153.3 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain WD40 PF00400.27 KOO53183.1 - 2e-13 49.6 2.4 7.5e-09 35.1 0.1 4.1 5 1 0 5 5 5 2 WD domain, G-beta repeat Apc4_WD40 PF12894.2 KOO53183.1 - 0.033 13.6 0.0 0.1 12.1 0.0 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain DUF3312 PF11768.3 KOO53183.1 - 0.27 9.3 0.0 1.1 7.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3312) Ion_trans PF00520.26 KOO53184.1 - 6e-85 283.5 28.5 1.1e-45 155.4 5.5 2.8 4 0 0 4 4 4 2 Ion transport protein PKD_channel PF08016.7 KOO53184.1 - 3.1e-05 22.5 7.5 3.1e-05 22.5 5.2 4.9 4 1 1 5 5 5 3 Polycystin cation channel DUF2627 PF11118.3 KOO53184.1 - 4.4 7.4 10.9 2.1 8.4 1.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) Spermine_synth PF01564.12 KOO53185.1 - 3.8e-58 196.3 0.0 4.9e-58 195.9 0.0 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_18 PF12847.2 KOO53185.1 - 3.8e-07 30.6 0.0 6.7e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO53185.1 - 4.9e-07 29.4 0.0 7.7e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO53185.1 - 5.5e-05 23.1 0.0 0.00011 22.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_30 PF05430.6 KOO53185.1 - 0.0001 21.9 0.0 0.00018 21.2 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_11 PF08241.7 KOO53185.1 - 0.00056 20.3 0.0 0.0037 17.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO53185.1 - 0.00057 20.2 0.0 0.0012 19.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOO53185.1 - 0.0045 16.3 0.0 0.0067 15.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_24 PF13578.1 KOO53185.1 - 0.0066 17.2 0.0 0.017 15.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO53185.1 - 0.046 14.2 0.0 0.13 12.7 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_5 PF01795.14 KOO53185.1 - 0.057 12.6 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 MraW methylase family TRM PF02005.11 KOO53185.1 - 0.08 11.8 0.0 1.4 7.7 0.0 2.1 2 0 0 2 2 2 0 N2,N2-dimethylguanosine tRNA methyltransferase Cons_hypoth95 PF03602.10 KOO53185.1 - 0.12 11.7 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Brix PF04427.13 KOO53187.1 - 2.4e-31 108.8 0.0 3.3e-31 108.4 0.0 1.2 1 0 0 1 1 1 1 Brix domain Methyltransf_31 PF13847.1 KOO53188.1 - 1.2e-31 109.3 0.0 1.8e-31 108.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO53188.1 - 3.2e-22 78.8 0.7 9.6e-22 77.2 0.0 2.1 3 0 0 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.13 KOO53188.1 - 2.7e-19 69.2 0.0 3.7e-19 68.7 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 KOO53188.1 - 1.4e-13 51.3 0.3 3.1e-13 50.2 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO53188.1 - 1.5e-13 50.9 1.1 1.1e-12 48.1 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO53188.1 - 5.2e-13 49.0 0.0 7.2e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO53188.1 - 6.6e-12 45.5 1.7 2e-11 43.9 1.2 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO53188.1 - 1.8e-10 41.1 0.0 3.1e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 KOO53188.1 - 1.2e-08 34.4 0.0 1.7e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.14 KOO53188.1 - 6.2e-07 29.1 0.0 1.4e-06 28.0 0.0 1.6 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_8 PF05148.10 KOO53188.1 - 5.5e-06 26.1 1.0 5.3e-05 22.9 0.7 2.1 1 1 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.9 KOO53188.1 - 4.5e-05 22.8 0.2 0.00011 21.5 0.1 1.7 1 1 1 2 2 2 1 Methyltransferase small domain Methyltransf_32 PF13679.1 KOO53188.1 - 0.011 15.4 0.0 0.02 14.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.12 KOO53188.1 - 0.013 14.5 0.0 0.026 13.5 0.0 1.5 2 0 0 2 2 2 0 Putative methyltransferase GCD14 PF08704.5 KOO53188.1 - 0.014 14.8 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit UPF0020 PF01170.13 KOO53188.1 - 0.019 14.5 0.0 0.035 13.6 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 GidB PF02527.10 KOO53188.1 - 0.037 13.1 0.1 0.074 12.1 0.0 1.5 1 1 0 1 1 1 0 rRNA small subunit methyltransferase G SNF2_N PF00176.18 KOO53191.1 - 5.3e-20 71.4 0.0 1.5e-19 69.8 0.0 1.7 1 1 0 1 1 1 1 SNF2 family N-terminal domain LRR_6 PF13516.1 KOO53192.1 - 5.1e-13 47.6 15.6 0.00056 19.7 0.1 8.6 8 0 0 8 8 8 4 Leucine Rich repeat LRR_1 PF00560.28 KOO53192.1 - 1.3e-07 30.6 2.4 1.5 9.1 0.0 6.3 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_7 PF13504.1 KOO53192.1 - 1.1e-05 24.8 6.1 1.6 9.2 0.0 6.5 5 1 0 5 5 5 2 Leucine rich repeat LRR_4 PF12799.2 KOO53192.1 - 2e-05 24.0 6.7 0.06 12.9 0.0 4.6 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO53192.1 - 0.0073 16.0 8.2 1.5 8.6 0.6 5.0 4 1 1 5 5 5 2 Leucine rich repeat FIBP PF05427.6 KOO53192.1 - 0.15 11.2 0.0 5.1 6.2 0.0 2.1 2 0 0 2 2 2 0 Acidic fibroblast growth factor binding (FIBP) DUF4098 PF13345.1 KOO53192.1 - 1.9 8.5 7.4 34 4.4 0.0 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4098) LRR_6 PF13516.1 KOO53194.1 - 0.011 15.6 0.0 0.21 11.7 0.0 2.8 3 0 0 3 3 3 0 Leucine Rich repeat SMC_hinge PF06470.8 KOO53195.1 - 1.1e-16 60.8 0.4 9.7e-16 57.8 0.0 2.8 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain PWWP PF00855.12 KOO53195.1 - 3.6e-13 49.5 0.0 3.6e-13 49.5 0.0 3.7 4 0 0 4 4 4 1 PWWP domain HMG_box PF00505.14 KOO53195.1 - 0.00032 20.9 0.1 0.00032 20.9 0.1 3.2 3 0 0 3 3 3 1 HMG (high mobility group) box Serpin PF00079.15 KOO53196.1 - 2e-67 227.9 0.0 2.2e-67 227.7 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SNF2_N PF00176.18 KOO53197.1 - 5.9e-40 136.9 0.2 1.2e-39 135.9 0.0 1.5 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOO53197.1 - 7e-15 54.6 0.0 1.8e-14 53.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain MBD PF01429.14 KOO53197.1 - 3.1e-05 23.4 4.7 0.00033 20.1 0.0 3.5 3 0 0 3 3 3 1 Methyl-CpG binding domain DEAD PF00270.24 KOO53197.1 - 0.00047 19.6 0.0 0.00094 18.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase CHDCT2 PF08074.6 KOO53197.1 - 0.084 12.6 0.0 0.084 12.6 0.0 3.1 3 0 0 3 3 3 0 CHDCT2 (NUC038) domain FAD_binding_4 PF01565.18 KOO53199.1 - 1.5e-18 66.5 5.4 1.5e-18 66.5 3.7 2.0 2 0 0 2 2 2 1 FAD binding domain adh_short PF00106.20 KOO53199.1 - 0.00028 20.8 0.6 0.00028 20.8 0.4 2.1 2 0 0 2 2 2 1 short chain dehydrogenase DUF563 PF04577.9 KOO53200.1 - 8.3e-10 38.9 0.0 1.3e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF563) EamA PF00892.15 KOO53204.1 - 3.1e-27 95.1 22.4 9.8e-14 51.4 5.7 2.3 2 0 0 2 2 2 2 EamA-like transporter family EmrE PF13536.1 KOO53204.1 - 1.9e-05 24.8 21.9 0.00012 22.1 4.8 2.9 2 2 0 2 2 2 2 Multidrug resistance efflux transporter UAA PF08449.6 KOO53204.1 - 0.008 15.1 5.1 0.01 14.7 3.6 1.2 1 0 0 1 1 1 1 UAA transporter family UPF0060 PF02694.10 KOO53204.1 - 0.91 9.5 9.2 0.088 12.8 2.0 2.5 2 1 0 2 2 2 0 Uncharacterised BCR, YnfA/UPF0060 family ACR_tran PF00873.14 KOO53204.1 - 5.5 4.2 7.2 0.65 7.3 0.9 2.0 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family EF-hand_7 PF13499.1 KOO53205.1 - 2.8e-13 49.7 0.4 6.7e-11 42.1 0.3 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO53205.1 - 4.1e-13 47.5 0.2 0.00014 20.8 0.0 3.8 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.1 KOO53205.1 - 1.7e-12 46.1 0.2 0.00083 19.0 0.1 3.7 3 1 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.1 KOO53205.1 - 1.7e-11 43.5 1.7 1.8e-08 33.8 0.0 3.8 2 2 2 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO53205.1 - 7.3e-09 34.5 0.6 0.015 14.5 0.0 3.5 3 0 0 3 3 3 2 EF hand WW PF00397.21 KOO53205.1 - 2.6e-07 30.3 3.1 5.4e-07 29.3 2.1 1.6 1 0 0 1 1 1 1 WW domain SPARC_Ca_bdg PF10591.4 KOO53205.1 - 0.00016 21.6 0.0 0.019 14.9 0.0 2.5 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 KOO53205.1 - 0.0018 18.1 0.1 0.67 9.9 0.0 2.9 3 0 0 3 3 3 1 EF-hand domain EF-hand_10 PF14788.1 KOO53205.1 - 0.003 17.1 0.1 0.018 14.6 0.0 2.1 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.2 KOO53205.1 - 0.025 14.3 0.2 15 5.4 0.0 3.0 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand TIG PF01833.19 KOO53208.1 - 0.043 13.8 0.0 0.12 12.3 0.0 1.7 1 1 0 1 1 1 0 IPT/TIG domain ATPgrasp_TupA PF14305.1 KOO53209.1 - 3.8e-09 36.2 0.0 1.7e-08 34.0 0.0 1.8 1 1 0 1 1 1 1 TupA-like ATPgrasp ATP-grasp_4 PF13535.1 KOO53209.1 - 4.6e-07 29.7 0.1 2.9e-06 27.1 0.1 1.9 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 KOO53209.1 - 0.087 11.5 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon Actin PF00022.14 KOO53210.1 - 2.9e-11 42.4 0.0 3.3e-09 35.6 0.0 2.3 1 1 1 2 2 2 2 Actin LRR_6 PF13516.1 KOO53212.1 - 2.4e-22 76.4 0.6 3.2e-05 23.5 0.0 5.5 6 0 0 6 6 6 4 Leucine Rich repeat LRR_7 PF13504.1 KOO53212.1 - 6.6e-05 22.4 0.2 17 6.1 0.0 4.9 5 0 0 5 5 5 1 Leucine rich repeat LRR_4 PF12799.2 KOO53212.1 - 0.0031 17.0 0.2 0.32 10.6 0.0 3.1 2 2 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO53212.1 - 0.0084 15.9 0.0 11 6.5 0.0 4.1 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_8 PF13855.1 KOO53212.1 - 0.047 13.4 0.0 3.8 7.3 0.0 3.4 4 1 0 4 4 4 0 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO53212.1 - 0.077 13.1 1.1 3.1 8.0 0.1 2.9 2 2 1 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding HOASN PF14515.1 KOO53212.1 - 2.6 8.4 4.9 9.6 6.6 0.2 3.1 1 1 3 4 4 4 0 Haem-oxygenase-associated N-terminal helices Phage_integ_N PF09003.5 KOO53212.1 - 3.9 7.2 4.8 34 4.2 0.1 2.9 3 0 0 3 3 3 0 Bacteriophage lambda integrase, N-terminal domain Glyco_hydro_3 PF00933.16 KOO53213.1 - 6.2e-83 278.2 0.0 9.5e-83 277.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.1 KOO53213.1 - 2.7e-19 68.8 0.0 7.3e-19 67.4 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III-like domain P2X_receptor PF00864.14 KOO53213.1 - 0.0045 15.7 3.0 0.0086 14.8 1.3 2.0 3 0 0 3 3 3 1 ATP P2X receptor CPSase_L_D2 PF02786.12 KOO53216.1 - 1.9e-72 242.9 0.2 2.9e-72 242.3 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.13 KOO53216.1 - 9.4e-63 211.1 0.0 1.4e-62 210.5 0.0 1.3 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_C PF02785.14 KOO53216.1 - 2e-30 104.9 0.0 6.8e-30 103.2 0.0 2.0 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.14 KOO53216.1 - 3.4e-30 105.4 0.0 5.7e-30 104.7 0.0 1.4 1 0 0 1 1 1 1 HMGL-like ATP-grasp_4 PF13535.1 KOO53216.1 - 1.3e-17 64.1 0.1 3e-17 62.9 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl PF00364.17 KOO53216.1 - 5.9e-17 61.0 2.8 5e-13 48.4 0.2 2.5 2 0 0 2 2 2 2 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.1 KOO53216.1 - 1.7e-12 46.7 6.7 0.00011 21.7 0.5 3.8 1 1 2 3 3 3 3 Biotin-lipoyl like Dala_Dala_lig_C PF07478.8 KOO53216.1 - 2.4e-08 33.6 0.0 6.2e-08 32.2 0.0 1.6 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.1 KOO53216.1 - 6.6e-08 31.6 0.1 0.00058 18.7 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 KOO53216.1 - 3.3e-05 23.2 0.0 0.00011 21.6 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain HlyD_3 PF13437.1 KOO53216.1 - 0.00022 21.5 0.9 1.7 8.9 0.0 3.9 4 0 0 4 4 4 2 HlyD family secretion protein RimK PF08443.6 KOO53216.1 - 0.00064 19.2 0.0 0.0038 16.7 0.0 2.1 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 KOO53216.1 - 0.0044 16.9 0.0 0.019 14.8 0.0 2.1 1 1 0 1 1 1 1 ATP-grasp domain HlyD PF00529.15 KOO53216.1 - 0.0062 15.8 8.1 0.96 8.6 0.2 3.7 3 1 2 5 5 5 2 HlyD family secretion protein HlyD_2 PF12700.2 KOO53216.1 - 0.007 15.5 0.2 0.85 8.7 0.0 2.3 1 1 1 2 2 2 1 HlyD family secretion protein 7TM-7TMR_HD PF07698.6 KOO53217.1 - 0.71 9.2 5.2 1.1 8.6 3.6 1.2 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase Peptidase_S51 PF03575.12 KOO53218.1 - 2.7e-10 40.2 0.0 4.5e-10 39.4 0.0 1.4 1 1 0 1 1 1 1 Peptidase family S51 Acyl-CoA_dh_2 PF08028.6 KOO53220.1 - 0.069 13.4 0.3 0.12 12.6 0.2 1.4 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain LRR_6 PF13516.1 KOO53221.1 - 2.2e-21 73.4 20.8 0.00062 19.5 0.0 11.7 13 0 0 13 13 13 6 Leucine Rich repeat LRR_1 PF00560.28 KOO53221.1 - 8.7e-08 31.1 0.3 17 5.9 0.0 8.3 9 0 0 9 9 9 1 Leucine Rich Repeat LRR_4 PF12799.2 KOO53221.1 - 3e-07 29.8 2.5 1.9 8.2 0.0 6.0 5 2 0 5 5 5 2 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO53221.1 - 0.0002 21.0 15.4 30 5.4 0.0 9.3 10 0 0 10 10 10 0 Leucine rich repeat LRR_8 PF13855.1 KOO53221.1 - 0.015 15.0 11.8 0.84 9.4 0.5 6.2 5 2 1 6 6 6 0 Leucine rich repeat Sigma70_r2 PF04542.9 KOO53223.1 - 1.3e-13 50.3 0.1 3.4e-13 48.9 0.1 1.7 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r3 PF04539.11 KOO53223.1 - 8.6e-10 38.3 7.6 2.3e-07 30.6 0.4 3.8 3 0 0 3 3 3 2 Sigma-70 region 3 Sigma70_r4 PF04545.11 KOO53223.1 - 9.4e-09 34.4 0.6 8.3e-07 28.2 0.2 2.6 2 0 0 2 2 2 2 Sigma-70, region 4 Sigma70_r1_2 PF00140.15 KOO53223.1 - 0.0028 17.3 0.1 0.0075 15.9 0.1 1.8 1 0 0 1 1 1 1 Sigma-70 factor, region 1.2 zf-RING_2 PF13639.1 KOO53224.1 - 6.6e-14 51.4 8.5 1.3e-13 50.5 5.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 KOO53224.1 - 2.7e-07 30.5 7.4 2.7e-07 30.5 5.1 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO53224.1 - 4.2e-07 29.5 7.6 7.7e-07 28.7 5.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 KOO53224.1 - 5.6e-07 29.1 5.7 1.1e-06 28.1 3.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 KOO53224.1 - 1e-06 28.3 7.1 1.8e-06 27.5 4.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 KOO53224.1 - 1.6e-06 28.1 4.0 3.3e-06 27.1 2.8 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 KOO53224.1 - 0.00041 20.1 2.6 0.00081 19.1 1.8 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 KOO53224.1 - 0.0022 17.6 2.2 0.0044 16.7 1.6 1.5 1 0 0 1 1 1 1 RING-type zinc-finger RINGv PF12906.2 KOO53224.1 - 0.024 14.6 7.6 0.068 13.2 5.3 1.8 1 0 0 1 1 1 0 RING-variant domain CoA_binding_3 PF13727.1 KOO53224.1 - 0.072 12.9 0.5 0.54 10.0 0.2 2.1 2 0 0 2 2 2 0 CoA-binding domain Prok-RING_1 PF14446.1 KOO53224.1 - 0.27 10.9 5.0 0.17 11.6 1.2 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-RING_4 PF14570.1 KOO53224.1 - 0.44 10.1 10.2 1.1 8.8 7.0 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Dmrt1 PF12374.3 KOO53224.1 - 3.8 7.9 8.4 3.2 8.1 4.0 2.1 2 0 0 2 2 2 0 Double-sex mab3 related transcription factor 1 FANCL_C PF11793.3 KOO53224.1 - 4.3 7.3 9.4 15 5.5 6.5 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain HORMA PF02301.13 KOO53226.1 - 1.9e-33 115.7 0.0 2.3e-33 115.4 0.0 1.1 1 0 0 1 1 1 1 HORMA domain EF-hand_7 PF13499.1 KOO53227.1 - 3.5e-08 33.4 0.4 1.2e-07 31.7 0.2 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.1 KOO53227.1 - 4.4e-06 26.2 0.3 0.0001 21.8 0.0 2.6 1 1 1 2 2 2 2 EF-hand domain pair NHL PF01436.16 KOO53227.1 - 9.1e-05 22.2 1.9 0.00033 20.4 0.0 2.9 3 0 0 3 3 3 1 NHL repeat EF-hand_6 PF13405.1 KOO53227.1 - 0.00029 20.4 0.1 0.02 14.7 0.0 3.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 KOO53227.1 - 0.00048 19.2 1.0 0.0091 15.2 0.0 3.1 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.1 KOO53227.1 - 0.0094 15.2 3.0 0.015 14.6 0.0 2.9 3 0 0 3 3 3 1 EF hand UPF0184 PF03670.8 KOO53227.1 - 0.014 15.5 1.6 0.076 13.1 1.1 2.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) EF-hand_5 PF13202.1 KOO53230.1 - 1.1e-15 56.1 0.1 1.4e-06 27.3 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_1 PF00036.27 KOO53230.1 - 1.5e-15 55.2 0.0 7.5e-08 31.1 0.1 3.3 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 KOO53230.1 - 2e-13 49.0 0.0 4e-05 23.1 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.1 KOO53230.1 - 1.4e-11 44.2 0.1 0.00021 21.3 0.0 2.9 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO53230.1 - 1e-08 34.6 0.2 0.00022 20.7 0.1 2.6 3 0 0 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO53230.1 - 0.00025 21.0 0.1 0.35 10.9 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.13 KOO53230.1 - 0.00078 19.0 2.8 0.78 9.5 0.0 2.7 2 0 0 2 2 2 2 Dockerin type I repeat VCBS PF13517.1 KOO53230.1 - 0.11 12.9 0.2 4.5 7.6 0.0 2.2 2 0 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO53230.1 - 0.26 11.0 1.1 2 8.2 0.1 2.3 2 0 0 2 2 2 0 FG-GAP repeat TFIIF_alpha PF05793.7 KOO53231.1 - 0.16 10.2 2.4 0.24 9.7 1.7 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SNF2_N PF00176.18 KOO53232.1 - 1.9e-38 131.9 0.0 2.7e-38 131.4 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF3072 PF11272.3 KOO53232.1 - 0.033 13.8 0.1 0.12 12.1 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3072) zf-RING_2 PF13639.1 KOO53232.1 - 1.7 8.5 12.6 0.58 10.0 0.6 2.6 2 0 0 2 2 2 0 Ring finger domain zf-RING_5 PF14634.1 KOO53232.1 - 6.8 6.5 13.3 0.065 12.9 0.7 2.5 2 0 0 2 2 2 0 zinc-RING finger domain DUF2681 PF10883.3 KOO53233.1 - 0.072 13.2 0.1 0.079 13.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) LRR_4 PF12799.2 KOO53234.1 - 1.9e-21 75.1 15.2 1e-05 24.9 1.2 5.4 3 1 3 6 6 6 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO53234.1 - 1e-17 63.6 20.5 3.6e-07 29.8 3.5 4.3 3 1 1 4 4 4 4 Leucine rich repeat LRR_1 PF00560.28 KOO53234.1 - 8.9e-11 40.2 19.4 0.84 9.9 0.1 9.3 10 0 0 10 10 10 4 Leucine Rich Repeat LRR_7 PF13504.1 KOO53234.1 - 7.9e-06 25.2 25.6 1.4 9.4 0.2 8.7 10 0 0 10 10 10 2 Leucine rich repeat LRR_9 PF14580.1 KOO53234.1 - 7.5e-05 22.3 6.3 0.031 13.8 0.2 3.1 1 1 2 3 3 3 3 Leucine-rich repeat MutS_III PF05192.13 KOO53234.1 - 0.0031 17.3 1.8 0.87 9.3 0.1 2.2 1 1 1 2 2 2 2 MutS domain III Miro PF08477.8 KOO53234.1 - 0.097 13.1 0.0 0.18 12.3 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein LRR_6 PF13516.1 KOO53234.1 - 0.41 10.8 10.7 67 4.0 0.0 6.0 7 1 1 8 8 8 0 Leucine Rich repeat FerA PF08165.6 KOO53234.1 - 4.6 6.9 7.5 25 4.6 0.0 3.9 4 0 0 4 4 4 0 FerA (NUC095) domain WD40 PF00400.27 KOO53236.1 - 2.9e-06 26.9 9.8 8.7e-05 22.2 0.5 4.1 5 0 0 5 5 5 2 WD domain, G-beta repeat PQQ_3 PF13570.1 KOO53236.1 - 1.3e-05 25.2 0.0 1.1 9.6 0.0 3.8 3 0 0 3 3 3 2 PQQ-like domain PQQ PF01011.16 KOO53236.1 - 0.0029 17.0 0.1 1.1 8.9 0.0 3.0 3 0 0 3 3 3 2 PQQ enzyme repeat DUF3529 PF12046.3 KOO53237.1 - 1.9e-42 144.2 0.0 2.6e-42 143.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3529) DUF2208 PF09973.4 KOO53237.1 - 0.061 12.5 0.5 0.13 11.4 0.0 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) FeoB_N PF02421.13 KOO53237.1 - 0.13 11.5 0.2 1.3 8.2 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B NAD_binding_10 PF13460.1 KOO53238.1 - 1e-05 25.6 0.9 1.5e-05 25.1 0.6 1.3 1 0 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 KOO53238.1 - 1.6e-05 24.8 6.2 5.3e-05 23.1 4.3 1.9 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 KOO53238.1 - 0.0005 19.7 0.4 0.00097 18.8 0.3 1.5 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.15 KOO53238.1 - 0.0007 19.7 0.9 0.0014 18.7 0.6 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.16 KOO53238.1 - 0.0036 16.7 0.1 0.0061 16.0 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.14 KOO53238.1 - 0.0068 15.5 0.1 0.012 14.8 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NmrA PF05368.8 KOO53238.1 - 0.0093 15.2 0.5 0.014 14.6 0.3 1.4 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.12 KOO53238.1 - 0.012 14.5 0.2 0.016 14.0 0.1 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Eno-Rase_NADH_b PF12242.3 KOO53238.1 - 0.046 13.5 2.8 0.13 12.0 1.9 1.8 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase F420_oxidored PF03807.12 KOO53238.1 - 0.048 14.0 0.5 0.12 12.8 0.4 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DFP PF04127.10 KOO53238.1 - 0.083 12.4 0.5 0.14 11.8 0.3 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein TPR_11 PF13414.1 KOO53239.1 - 1.1e-32 111.4 29.0 3.4e-06 26.6 0.0 9.3 6 2 3 9 9 9 8 TPR repeat TPR_1 PF00515.23 KOO53239.1 - 2.4e-15 55.3 25.5 0.014 14.9 0.0 12.0 15 0 0 15 15 15 4 Tetratricopeptide repeat TPR_2 PF07719.12 KOO53239.1 - 7.4e-15 53.6 43.7 0.031 14.1 0.0 12.8 14 0 0 14 14 14 6 Tetratricopeptide repeat TPR_17 PF13431.1 KOO53239.1 - 4.7e-10 38.8 10.5 0.0054 16.8 0.0 8.2 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_9 PF13371.1 KOO53239.1 - 2.5e-09 36.8 75.5 0.0024 17.7 2.4 11.1 7 4 5 12 12 12 7 Tetratricopeptide repeat TPR_8 PF13181.1 KOO53239.1 - 2.5e-08 33.1 0.1 0.028 14.1 0.0 6.8 7 1 0 8 8 8 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO53239.1 - 2.5e-06 28.0 33.2 0.0041 17.7 1.3 10.4 8 2 2 10 10 8 4 Tetratricopeptide repeat TPR_12 PF13424.1 KOO53239.1 - 8.1e-06 25.6 38.9 0.0021 17.9 0.7 8.9 7 3 3 10 10 10 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOO53239.1 - 0.00049 20.3 0.3 0.00049 20.3 0.2 6.6 7 1 0 7 7 6 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO53239.1 - 0.0025 18.2 6.3 0.033 14.8 1.4 13.1 10 4 3 13 13 11 5 Tetratricopeptide repeat TPR_6 PF13174.1 KOO53239.1 - 0.01 16.2 28.1 0.01 16.2 0.0 9.4 12 0 0 12 12 11 0 Tetratricopeptide repeat TPR_20 PF14561.1 KOO53239.1 - 0.072 13.2 0.0 0.072 13.2 0.0 6.1 6 1 2 8 8 8 0 Tetratricopeptide repeat Surp PF01805.15 KOO53240.1 - 1.8e-38 129.9 0.1 8.6e-20 70.1 0.0 2.4 2 0 0 2 2 2 2 Surp module PRP21_like_P PF12230.3 KOO53240.1 - 4.5e-27 95.0 0.3 1.4e-17 64.0 0.0 2.5 1 1 1 2 2 2 2 Pre-mRNA splicing factor PRP21 like protein Ku_C PF03730.9 KOO53240.1 - 0.095 13.2 1.5 0.75 10.3 0.1 2.7 3 0 0 3 3 3 0 Ku70/Ku80 C-terminal arm zf-C2H2_2 PF12756.2 KOO53241.1 - 2.3e-16 59.7 0.0 3.7e-15 55.8 0.0 2.1 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 KOO53241.1 - 0.078 13.1 0.9 0.18 11.9 0.0 2.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Clr5 PF14420.1 KOO53241.1 - 0.38 10.6 4.9 5.6 6.9 0.0 3.3 3 1 0 3 3 3 0 Clr5 domain FAM194 PF14977.1 KOO53242.1 - 4.2e-28 97.7 0.0 7.9e-28 96.8 0.0 1.3 1 0 0 1 1 1 1 FAM194 protein Glyco_hydro_43 PF04616.9 KOO53243.1 - 0.061 12.4 0.1 2.3 7.2 0.0 2.7 2 1 1 3 3 3 0 Glycosyl hydrolases family 43 Glyco_hydro_3_C PF01915.17 KOO53244.1 - 3.1e-39 134.8 0.1 5e-39 134.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.1 KOO53244.1 - 1.2e-24 86.0 0.0 2.3e-24 85.1 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Glyco_hydro_3 PF00933.16 KOO53245.1 - 5.2e-75 252.1 0.0 6.2e-75 251.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain DENN PF02141.16 KOO53246.1 - 3.5e-22 79.0 0.1 5.8e-22 78.3 0.1 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.13 KOO53246.1 - 5.3e-06 26.3 0.1 2.6e-05 24.0 0.0 2.1 2 0 0 2 2 2 1 uDENN domain Glyco_hydro_3_C PF01915.17 KOO53246.1 - 0.019 14.5 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain CAP PF00188.21 KOO53247.1 - 1.4e-10 41.7 0.0 2.3e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family EF-hand_1 PF00036.27 KOO53247.1 - 0.00057 18.9 0.0 0.0047 16.1 0.0 2.4 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.1 KOO53247.1 - 0.0018 17.5 0.0 0.0062 15.8 0.0 1.9 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO53247.1 - 0.025 14.6 0.0 0.077 13.1 0.0 1.7 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.1 KOO53247.1 - 0.044 13.6 0.0 0.25 11.3 0.0 2.2 3 0 0 3 3 3 0 EF-hand domain Filamin PF00630.14 KOO53248.1 - 1.6e-06 28.5 0.0 0.48 11.0 0.0 3.4 3 0 0 3 3 3 3 Filamin/ABP280 repeat Acyltransferase PF01553.16 KOO53250.1 - 5.9e-10 38.6 0.0 8.3e-10 38.2 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Filamin PF00630.14 KOO53253.1 - 2.1e-07 31.4 0.0 2.1e-05 25.0 0.0 2.1 2 0 0 2 2 2 2 Filamin/ABP280 repeat TSCPD PF12637.2 KOO53253.1 - 0.12 12.3 0.0 0.25 11.3 0.0 1.5 1 1 1 2 2 2 0 TSCPD domain Big_3_4 PF13754.1 KOO53253.1 - 0.13 12.6 0.0 0.28 11.5 0.0 1.6 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) zf-C3HC4 PF00097.20 KOO53254.1 - 1.6e-05 24.4 5.9 3.1e-05 23.5 4.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO53254.1 - 2.9e-05 23.6 8.8 5.6e-05 22.7 6.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 KOO53254.1 - 3.8e-05 23.6 7.3 8.3e-05 22.5 5.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 KOO53254.1 - 0.00082 18.9 7.4 0.0016 18.0 5.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO53254.1 - 0.0059 16.4 9.9 0.011 15.5 6.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.1 KOO53254.1 - 0.02 14.5 4.2 0.11 12.2 0.4 2.6 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_4 PF15227.1 KOO53254.1 - 0.021 14.7 9.2 0.029 14.2 5.6 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.1 KOO53254.1 - 0.077 12.5 6.6 0.19 11.3 4.5 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.1 KOO53254.1 - 0.13 11.8 7.9 0.46 10.0 5.5 2.0 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-UDP PF14569.1 KOO53254.1 - 0.19 11.4 3.2 0.49 10.1 2.2 1.7 1 0 0 1 1 1 0 Zinc-binding RING-finger Kinetocho_Slk19 PF12709.2 KOO53254.1 - 0.23 11.5 17.4 0.037 14.0 1.6 3.7 2 2 2 4 4 4 0 Central kinetochore-associated GYD PF08734.6 KOO53254.1 - 0.57 9.9 4.6 1.6 8.5 0.2 3.0 1 1 2 3 3 3 0 GYD domain Baculo_IE-1 PF05290.6 KOO53254.1 - 0.58 9.8 8.6 0.15 11.7 3.3 2.0 2 1 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) TPR_MLP1_2 PF07926.7 KOO53254.1 - 0.64 9.7 29.4 0.68 9.6 6.6 3.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein CCDC84 PF14968.1 KOO53254.1 - 0.76 9.2 9.6 1.2 8.5 0.0 3.1 3 0 0 3 3 3 0 Coiled coil protein 84 FTA4 PF13093.1 KOO53254.1 - 1.1 8.6 9.4 0.063 12.7 2.0 2.0 2 0 0 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF3138 PF11336.3 KOO53254.1 - 5.9 4.9 13.9 1.1 7.3 3.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) HATPase_c PF02518.21 KOO53255.1 - 3.2e-07 30.0 0.0 7.3e-07 28.8 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PDZ PF00595.19 KOO53257.1 - 2.8e-07 30.6 0.0 6.6e-06 26.2 0.0 2.4 1 1 1 2 2 2 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO53257.1 - 1.4e-06 28.0 0.0 5.4e-05 22.9 0.0 2.8 3 0 0 3 3 3 1 PDZ domain FAIM1 PF06905.8 KOO53257.1 - 5.9e-05 22.3 0.2 0.00013 21.1 0.1 1.5 1 1 0 1 1 1 1 Fas apoptotic inhibitory molecule (FAIM1) SNF2_N PF00176.18 KOO53258.1 - 3.6e-40 137.6 0.0 4.8e-40 137.2 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 KOO53258.1 - 2.5e-13 49.6 0.0 4.6e-13 48.8 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-CXXC PF02008.15 KOO53258.1 - 1e-07 31.6 2.7 1e-07 31.6 1.8 1.9 2 0 0 2 2 2 1 CXXC zinc finger domain AAA_22 PF13401.1 KOO53258.1 - 0.036 14.2 0.0 0.35 11.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain ResIII PF04851.10 KOO53258.1 - 0.062 13.1 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DEAD PF00270.24 KOO53258.1 - 0.062 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase Beta_helix PF13229.1 KOO53259.1 - 7.6e-11 42.0 7.7 9.9e-11 41.6 5.4 1.1 1 0 0 1 1 1 1 Right handed beta helix region NosD PF05048.8 KOO53259.1 - 2.4e-06 26.8 1.6 3.3e-06 26.4 1.1 1.1 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) Chlam_PMP PF02415.12 KOO53259.1 - 0.0098 16.1 19.1 0.41 11.0 0.8 4.8 4 1 0 4 4 4 3 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat Pentapeptide_3 PF13576.1 KOO53259.1 - 0.093 12.6 3.7 0.22 11.4 1.6 2.2 2 1 0 2 2 2 0 Pentapeptide repeats (9 copies) SSB PF00436.20 KOO53259.1 - 0.54 10.1 2.4 3.7 7.4 0.0 2.4 1 1 1 2 2 2 0 Single-strand binding protein family TNFR_c6 PF00020.13 KOO53259.1 - 8.2 6.5 8.5 54 3.9 0.0 3.9 4 0 0 4 4 4 0 TNFR/NGFR cysteine-rich region ARID PF01388.16 KOO53261.1 - 0.043 13.6 0.0 0.073 12.9 0.0 1.3 1 1 0 1 1 1 0 ARID/BRIGHT DNA binding domain DUF3091 PF11291.3 KOO53261.1 - 0.086 12.8 0.1 0.1 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3091) LRR_6 PF13516.1 KOO53262.1 - 1.3e-21 74.1 0.7 0.00016 21.4 0.0 6.2 6 0 0 6 6 6 4 Leucine Rich repeat LRR_4 PF12799.2 KOO53262.1 - 3.1e-10 39.4 0.0 0.038 13.6 0.0 4.2 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO53262.1 - 0.00023 20.8 0.2 0.78 9.5 0.1 4.0 3 1 0 3 3 3 1 Leucine rich repeat LRR_1 PF00560.28 KOO53262.1 - 0.0011 18.7 2.1 15 6.0 0.0 4.2 4 1 0 4 4 4 1 Leucine Rich Repeat LRR_7 PF13504.1 KOO53262.1 - 0.007 16.3 2.8 12 6.6 0.0 5.0 5 0 0 5 5 5 1 Leucine rich repeat Ank_2 PF12796.2 KOO53262.1 - 0.05 13.9 0.3 0.29 11.4 0.2 2.4 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) Cyclin PF08613.6 KOO53263.1 - 3.5e-10 40.4 0.0 5.6e-10 39.8 0.0 1.4 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 KOO53263.1 - 9.3e-09 34.9 0.0 3.2e-08 33.1 0.0 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain VCBS PF13517.1 KOO53264.1 - 3.2e-41 139.4 43.4 2.1e-13 50.3 5.8 4.2 1 1 3 4 4 4 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 KOO53264.1 - 6e-26 89.4 24.3 2e-06 27.3 0.0 4.4 4 0 0 4 4 4 4 FG-GAP repeat TcdB_toxin_midN PF12256.3 KOO53264.1 - 1.1e-11 44.5 10.6 0.0084 15.5 0.1 4.2 1 1 3 4 4 4 4 Insecticide toxin TcdB middle/N-terminal region EF-hand_5 PF13202.1 KOO53264.1 - 0.2 11.0 22.3 6.2 6.3 0.6 4.3 4 0 0 4 4 4 0 EF hand Asp-B-Hydro_N PF05279.6 KOO53264.1 - 0.55 10.0 12.3 31 4.3 0.1 4.1 4 0 0 4 4 4 0 Aspartyl beta-hydroxylase N-terminal region EF-hand_1 PF00036.27 KOO53264.1 - 0.59 9.5 15.2 17 4.9 0.2 4.2 4 0 0 4 4 4 0 EF hand WD40 PF00400.27 KOO53265.1 - 9.9e-90 291.5 15.9 2.3e-11 43.1 0.1 8.1 8 0 0 8 8 8 8 WD domain, G-beta repeat Nup160 PF11715.3 KOO53265.1 - 1.9e-11 42.8 8.7 0.013 13.6 0.0 6.3 1 1 3 4 4 4 4 Nucleoporin Nup120/160 eIF2A PF08662.6 KOO53265.1 - 1.8e-07 31.0 1.6 0.012 15.3 0.1 3.2 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.6 KOO53265.1 - 8.4e-05 21.4 0.7 0.13 10.9 0.2 2.9 1 1 1 2 2 2 2 Nup133 N terminal like CEP19 PF14933.1 KOO53265.1 - 0.0083 16.4 0.0 0.012 15.8 0.0 1.2 1 0 0 1 1 1 1 CEP19-like protein Fimbrial_K88 PF02432.10 KOO53265.1 - 0.016 14.6 0.4 4.6 6.6 0.0 2.9 2 2 1 3 3 3 0 Fimbrial, major and minor subunit Ank_2 PF12796.2 KOO53266.1 - 1e-37 128.3 7.3 1.1e-19 70.4 0.8 2.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO53266.1 - 1.1e-27 94.3 2.0 7.4e-08 31.8 0.2 5.4 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.1 KOO53266.1 - 1.1e-18 67.1 0.8 2.2e-08 34.3 0.0 4.1 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO53266.1 - 1.5e-18 66.3 2.0 8e-07 29.1 0.0 3.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO53266.1 - 9.4e-15 53.2 2.4 0.00073 19.5 0.1 5.0 5 0 0 5 5 5 3 Ankyrin repeat U1snRNP70_N PF12220.3 KOO53267.1 - 1.8e-20 73.0 0.4 3.1e-20 72.2 0.3 1.4 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.17 KOO53267.1 - 8.6e-18 63.7 0.0 1.3e-17 63.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO53267.1 - 5e-13 48.8 0.0 9.2e-13 47.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO53267.1 - 1.3e-07 31.3 0.0 2.2e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TIM21 PF08294.6 KOO53268.1 - 6.5e-12 45.3 0.0 9.4e-12 44.8 0.0 1.1 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.5 KOO53268.1 - 0.00019 20.9 0.0 0.00046 19.6 0.0 1.6 1 1 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 DUF829 PF05705.9 KOO53268.1 - 0.0017 18.0 0.0 0.003 17.2 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) DUF1470 PF07336.6 KOO53269.1 - 0.031 14.6 1.7 0.04 14.2 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1470) TLD PF07534.11 KOO53270.1 - 5.1e-23 81.6 0.0 7.4e-23 81.0 0.0 1.2 1 0 0 1 1 1 1 TLD Arm PF00514.18 KOO53271.1 - 0.0082 15.9 0.4 3.6 7.5 0.0 2.9 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat EF-hand_1 PF00036.27 KOO53271.1 - 0.15 11.4 0.2 0.3 10.4 0.2 1.5 1 0 0 1 1 1 0 EF hand WD40 PF00400.27 KOO53272.1 - 5.3e-77 251.1 29.2 6.9e-13 47.9 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat PD40 PF07676.7 KOO53272.1 - 7.9e-18 63.7 4.8 0.36 10.5 0.0 7.3 7 0 0 7 7 7 7 WD40-like Beta Propeller Repeat eIF2A PF08662.6 KOO53272.1 - 4.1e-10 39.6 0.0 0.0014 18.4 0.0 3.0 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A DUF3312 PF11768.3 KOO53272.1 - 9.1e-06 24.1 0.0 0.5 8.5 0.0 3.7 1 1 4 5 5 5 5 Protein of unknown function (DUF3312) DCX PF03607.12 KOO53272.1 - 0.011 15.3 0.0 1.1 8.8 0.0 3.9 5 1 1 6 6 6 0 Doublecortin IKI3 PF04762.7 KOO53272.1 - 0.012 13.4 0.0 5.9 4.5 0.0 3.5 1 1 2 4 4 4 0 IKI3 family RHS_repeat PF05593.9 KOO53272.1 - 0.018 15.2 0.0 17 5.7 0.0 3.6 2 1 1 3 3 3 0 RHS Repeat Esterase_phd PF10503.4 KOO53272.1 - 0.12 11.6 0.1 3.3 6.9 0.0 2.7 1 1 1 3 3 3 0 Esterase PHB depolymerase Proteasome_A_N PF10584.4 KOO53272.1 - 2.5 7.4 15.7 31 4.0 0.0 6.4 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature BRO1 PF03097.13 KOO53273.1 - 8.6e-71 238.6 2.5 8.6e-71 238.6 1.8 1.7 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 KOO53273.1 - 1.4e-20 73.4 0.7 6.4e-11 41.7 0.0 3.0 2 1 1 3 3 3 2 ALIX V-shaped domain binding to HIV UBA PF00627.26 KOO53273.1 - 1.9e-15 56.1 0.5 2.3e-06 27.2 0.0 3.1 2 0 0 2 2 2 2 UBA/TS-N domain PDZ_2 PF13180.1 KOO53273.1 - 3.3e-08 33.3 0.1 8.5e-08 31.9 0.0 1.6 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.19 KOO53273.1 - 8.6e-08 32.2 0.1 1.8e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) CUE PF02845.11 KOO53273.1 - 0.07 12.6 0.0 3.9 7.0 0.0 3.0 3 0 0 3 3 3 0 CUE domain Tricorn_PDZ PF14685.1 KOO53273.1 - 0.15 11.8 0.0 0.37 10.6 0.0 1.6 1 0 0 1 1 1 0 Tricorn protease PDZ domain DUF3173 PF11372.3 KOO53273.1 - 0.18 11.4 0.0 20 4.8 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3173) DUF3225 PF11533.3 KOO53273.1 - 1.3 8.6 5.3 0.59 9.8 0.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3225) ACT_7 PF13840.1 KOO53274.1 - 9.5e-22 76.3 0.0 1.8e-10 40.1 0.0 2.4 2 0 0 2 2 2 2 ACT domain UCH_1 PF13423.1 KOO53274.1 - 0.03 13.7 0.0 0.032 13.6 0.0 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Pcc1 PF09341.5 KOO53276.1 - 0.51 10.4 6.4 8 6.5 0.1 4.5 2 2 3 5 5 5 0 Transcription factor Pcc1 Peptidase_M30 PF10460.4 KOO53276.1 - 2.8 6.7 6.1 1.3 7.8 0.1 3.0 3 1 1 4 4 4 0 Peptidase M30 Aminotran_3 PF00202.16 KOO53277.1 - 2.9e-101 338.7 0.0 3.5e-101 338.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.16 KOO53277.1 - 0.0016 17.6 0.0 0.0028 16.8 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Toxin_55 PF15606.1 KOO53278.1 - 0.065 13.2 1.2 0.43 10.5 0.1 2.6 2 1 1 3 3 3 0 Putative toxin 55 CVNH PF08881.5 KOO53278.1 - 0.37 11.0 4.1 0.31 11.2 0.6 2.4 2 1 0 2 2 2 0 CVNH domain Baculo_PEP_C PF04513.7 KOO53278.1 - 2.8 7.7 5.5 5 6.9 0.4 3.3 2 2 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus LCAT PF02450.10 KOO53279.1 - 7.1e-25 87.7 0.0 1.9e-19 69.9 0.0 2.0 1 1 1 2 2 2 2 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.2 KOO53279.1 - 1.3e-06 28.4 0.1 2.3e-06 27.6 0.1 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.9 KOO53279.1 - 0.086 12.1 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Putative serine esterase (DUF676) DUF915 PF06028.6 KOO53279.1 - 0.11 11.6 0.0 0.2 10.6 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_5 PF12695.2 KOO53279.1 - 0.13 11.9 0.0 0.28 10.9 0.0 1.3 1 1 0 1 1 1 0 Alpha/beta hydrolase family Mito_carr PF00153.22 KOO53280.1 - 8.1e-66 217.7 5.5 1e-24 86.0 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Spc97_Spc98 PF04130.8 KOO53281.1 - 3.7e-35 121.2 0.0 4.3e-35 121.0 0.0 1.1 1 0 0 1 1 1 1 Spc97 / Spc98 family JmjC PF02373.17 KOO53282.1 - 4.4e-33 113.9 0.0 8.7e-33 112.9 0.0 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.12 KOO53282.1 - 4.5e-13 48.4 0.1 7.8e-13 47.7 0.1 1.4 1 0 0 1 1 1 1 jmjN domain zf-C3HC PF07967.8 KOO53282.1 - 0.016 15.0 0.2 0.066 12.9 0.0 2.1 3 0 0 3 3 3 0 C3HC zinc finger-like zf-RanBP PF00641.13 KOO53282.1 - 0.12 11.5 2.1 0.28 10.3 1.5 1.7 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others Kelch_1 PF01344.20 KOO53283.1 - 6.6e-96 313.6 0.0 1.1e-16 60.1 0.0 6.1 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.1 KOO53283.1 - 7.9e-65 212.5 0.0 2.4e-12 46.4 0.0 6.1 2 2 4 6 6 6 6 Kelch motif Kelch_2 PF07646.10 KOO53283.1 - 4.4e-56 184.6 0.0 2.5e-10 39.6 0.0 6.1 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.1 KOO53283.1 - 2.3e-52 174.5 0.0 3.9e-09 36.1 0.0 6.2 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.1 KOO53283.1 - 1.4e-48 162.0 0.1 2.8e-07 30.4 0.0 6.1 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO53283.1 - 2e-30 104.2 6.0 2.4e-06 27.3 0.0 6.7 7 0 0 7 7 7 5 Kelch motif DUF721 PF05258.7 KOO53283.1 - 1.4e-09 37.9 0.0 1.2 9.4 0.0 5.0 4 1 1 5 5 5 3 Protein of unknown function (DUF721) PQQ_3 PF13570.1 KOO53283.1 - 2.1e-08 34.1 18.6 0.37 11.1 0.1 5.7 4 1 2 6 6 6 4 PQQ-like domain Glyoxal_oxid_N PF07250.6 KOO53283.1 - 5.7e-07 28.8 0.0 0.068 12.2 0.0 3.5 1 1 3 4 4 4 2 Glyoxal oxidase N-terminus DUF1668 PF07893.8 KOO53283.1 - 7.5e-07 28.5 5.7 1.5 7.8 0.0 5.1 1 1 4 5 5 5 4 Protein of unknown function (DUF1668) Rax2 PF12768.2 KOO53283.1 - 5.5e-06 25.7 0.0 0.061 12.5 0.0 3.2 3 0 0 3 3 3 2 Cortical protein marker for cell polarity Glycophorin_A PF01102.13 KOO53283.1 - 0.077 12.7 0.0 6.5 6.5 0.0 3.4 4 0 0 4 4 4 0 Glycophorin A PsbW PF07123.7 KOO53283.1 - 0.2 11.7 5.0 7.3 6.6 0.1 3.0 3 0 0 3 3 3 0 Photosystem II reaction centre W protein (PsbW) OMP_b-brl PF13505.1 KOO53283.1 - 1.3 8.9 4.3 7.7 6.4 0.1 3.2 2 1 1 3 3 3 0 Outer membrane protein beta-barrel domain ESX-1_EspG PF14011.1 KOO53283.1 - 1.7 7.7 7.2 1.2 8.2 1.0 3.1 1 1 1 2 2 2 0 EspG family DUF1028 PF06267.7 KOO53284.1 - 0.0058 16.0 2.2 3.3 7.1 0.0 3.4 1 1 3 4 4 4 2 Family of unknown function (DUF1028) OMPdecase PF00215.19 KOO53284.1 - 0.049 13.0 0.0 3.6 6.9 0.0 3.0 2 1 0 2 2 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family DUF1970 PF09301.5 KOO53284.1 - 1.2 9.2 11.3 1.8 8.6 0.3 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF1970) YchF-GTPase_C PF06071.8 KOO53286.1 - 1.7e-37 127.0 0.4 2e-37 126.8 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF933) LRR_6 PF13516.1 KOO53289.1 - 5.9e-23 78.3 45.7 0.13 12.3 0.0 15.6 16 0 0 16 16 16 10 Leucine Rich repeat LRR_1 PF00560.28 KOO53289.1 - 1.4e-18 64.0 16.6 1.2 9.4 0.2 12.6 13 0 0 13 13 13 6 Leucine Rich Repeat LRR_4 PF12799.2 KOO53289.1 - 2.9e-13 49.0 25.4 0.16 11.6 0.0 10.4 10 0 0 10 10 10 5 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO53289.1 - 5.6e-13 46.8 30.1 1.3 9.4 0.5 13.0 13 0 0 13 13 13 2 Leucine rich repeat LRR_8 PF13855.1 KOO53289.1 - 1.5e-07 31.0 22.3 22 4.8 0.1 10.6 11 1 0 11 11 10 0 Leucine rich repeat SpoU_sub_bind PF08032.7 KOO53289.1 - 0.0025 17.9 5.1 48 4.2 0.0 6.1 6 3 1 7 7 6 0 RNA 2'-O ribose methyltransferase substrate binding EIF_2_alpha PF07541.7 KOO53289.1 - 0.0029 17.3 4.9 4.8 6.9 0.0 5.9 7 3 1 8 8 8 1 Eukaryotic translation initiation factor 2 alpha subunit PCP PF02429.10 KOO53289.1 - 0.052 13.6 8.2 56 3.8 0.0 6.1 5 3 2 7 7 7 0 Peridinin-chlorophyll A binding protein HTH_40 PF14493.1 KOO53289.1 - 0.099 12.8 0.6 71 3.7 0.0 3.6 3 0 0 3 3 3 0 Helix-turn-helix domain DUF4314 PF14192.1 KOO53289.1 - 0.11 12.8 0.0 67 3.8 0.0 4.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4314) DUF2202 PF09968.4 KOO53289.1 - 0.13 11.9 2.4 41 3.8 0.0 4.2 5 0 0 5 5 5 0 Uncharacterized protein domain (DUF2202) Dispanin PF04505.7 KOO53289.1 - 0.72 9.4 5.2 3.1 7.4 0.1 4.3 7 0 0 7 7 7 0 Interferon-induced transmembrane protein Ras PF00071.17 KOO53290.1 - 2.3e-55 186.3 0.2 2.7e-55 186.1 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 KOO53290.1 - 5.5e-18 65.5 0.0 9.5e-18 64.8 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 KOO53290.1 - 9.2e-14 51.0 0.0 1.1e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 KOO53290.1 - 2.4e-06 26.9 0.0 3.6e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 KOO53290.1 - 5.5e-06 25.6 0.0 7.6e-06 25.2 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 KOO53290.1 - 0.00017 21.0 0.0 0.00035 20.0 0.0 1.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 KOO53290.1 - 0.00047 20.0 0.2 0.0032 17.4 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 KOO53290.1 - 0.0053 16.0 0.4 0.074 12.3 0.3 2.5 1 1 0 1 1 1 1 Ferrous iron transport protein B PduV-EutP PF10662.4 KOO53290.1 - 0.0073 15.7 0.1 2.7 7.4 0.0 2.2 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.1 KOO53290.1 - 0.008 15.7 0.2 0.01 15.4 0.2 1.5 1 1 0 1 1 1 1 AAA domain Sec16_C PF12931.2 KOO53290.1 - 0.013 15.2 0.3 0.022 14.5 0.2 1.4 1 1 0 1 1 1 0 Sec23-binding domain of Sec16 AAA_22 PF13401.1 KOO53290.1 - 0.049 13.7 0.2 0.21 11.7 0.2 2.1 1 1 0 1 1 1 0 AAA domain Pox_A32 PF04665.7 KOO53290.1 - 0.058 12.6 0.0 0.13 11.5 0.0 1.6 1 1 0 1 1 1 0 Poxvirus A32 protein AAA_33 PF13671.1 KOO53290.1 - 0.058 13.2 0.0 0.11 12.3 0.0 1.4 1 1 0 1 1 1 0 AAA domain KaiC PF06745.8 KOO53290.1 - 0.059 12.4 0.2 0.15 11.1 0.1 1.5 1 1 0 1 1 1 0 KaiC AAA_16 PF13191.1 KOO53290.1 - 0.11 12.4 2.3 0.75 9.7 1.6 2.1 1 1 0 1 1 1 0 AAA ATPase domain DUF258 PF03193.11 KOO53290.1 - 0.13 11.4 1.0 0.8 8.8 0.2 2.6 2 1 0 3 3 3 0 Protein of unknown function, DUF258 TTL PF03133.10 KOO53291.1 - 1.3e-73 247.5 0.0 2.1e-73 246.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.1 KOO53291.1 - 1.9e-05 23.6 0.0 0.00016 20.5 0.0 2.2 2 0 0 2 2 2 1 YheC/D like ATP-grasp W2 PF02020.13 KOO53292.1 - 1.8e-09 37.3 0.1 2e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon DSPc PF00782.15 KOO53294.1 - 7.1e-16 57.9 0.0 1e-15 57.4 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 KOO53294.1 - 0.0086 15.4 0.1 0.014 14.7 0.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 KOO53294.1 - 0.16 11.9 0.0 0.29 11.1 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate DNA_mis_repair PF01119.14 KOO53295.1 - 4e-32 110.1 0.0 6.3e-32 109.5 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 KOO53295.1 - 9.2e-10 38.3 0.0 1.5e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 KOO53295.1 - 9.8e-08 31.6 0.0 2.2e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.6 KOO53295.1 - 0.00011 21.7 0.1 0.00025 20.6 0.0 1.6 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DUF4510 PF14971.1 KOO53295.1 - 0.25 11.4 3.7 11 6.1 0.0 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF4510) ALIX_LYPXL_bnd PF13949.1 KOO53296.1 - 0.005 15.8 0.4 0.0075 15.2 0.3 1.3 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV IncA PF04156.9 KOO53296.1 - 0.062 12.8 3.0 0.093 12.3 2.1 1.2 1 0 0 1 1 1 0 IncA protein Atg14 PF10186.4 KOO53296.1 - 0.089 11.7 1.1 0.11 11.4 0.7 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Enkurin PF13864.1 KOO53296.1 - 0.32 11.2 4.6 0.45 10.7 0.2 2.2 1 1 1 2 2 2 0 Calmodulin-binding Ribosomal_L13 PF00572.13 KOO53297.1 - 4e-23 81.8 0.0 6.4e-23 81.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L13 Ribosomal_L27e PF01777.13 KOO53298.1 - 1.2e-31 108.6 5.1 1.9e-31 107.9 3.5 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.24 KOO53298.1 - 0.0012 18.5 0.1 0.0025 17.4 0.0 1.6 1 0 0 1 1 1 1 KOW motif DUF179 PF02622.10 KOO53299.1 - 0.0011 18.6 0.0 0.0017 18.0 0.0 1.4 1 1 0 1 1 1 1 Uncharacterized ACR, COG1678 RRM_1 PF00076.17 KOO53300.1 - 0.0011 18.5 0.0 0.0026 17.3 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PseudoU_synth_1 PF01416.15 KOO53300.1 - 0.0011 19.3 0.0 0.0022 18.3 0.0 1.6 1 0 0 1 1 1 1 tRNA pseudouridine synthase RRM_5 PF13893.1 KOO53300.1 - 0.0013 18.5 0.0 0.0031 17.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO53300.1 - 0.0061 16.5 0.0 0.021 14.7 0.0 1.9 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Haem_oxygenas_2 PF14518.1 KOO53300.1 - 0.14 12.3 0.3 1.5 9.0 0.1 2.6 2 1 1 3 3 3 0 Iron-containing redox enzyme Ribosomal_60s PF00428.14 KOO53301.1 - 0.015 15.6 11.2 0.34 11.3 2.6 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein Retrotrans_gag PF03732.12 KOO53301.1 - 0.1 12.6 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Retrotransposon gag protein CENP-B_dimeris PF09026.5 KOO53301.1 - 2.2 8.5 6.3 14 5.9 4.5 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF2693 PF10902.3 KOO53302.1 - 0.4 10.6 2.8 26 4.7 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2693) WD40 PF00400.27 KOO53303.1 - 5.5e-20 70.4 1.6 1.6e-05 24.6 0.0 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat Kinesin PF00225.18 KOO53303.1 - 0.00046 19.0 0.0 0.00059 18.6 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain HSP70 PF00012.15 KOO53305.1 - 0.076 10.9 0.3 0.082 10.8 0.2 1.0 1 0 0 1 1 1 0 Hsp70 protein PABP PF00658.13 KOO53306.1 - 4.8e-08 32.5 0.3 1.2e-07 31.2 0.2 1.6 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain OTU PF02338.14 KOO53306.1 - 9.4e-08 32.6 0.0 2.3e-07 31.3 0.0 1.7 2 0 0 2 2 2 1 OTU-like cysteine protease NHase_beta PF02211.10 KOO53306.1 - 0.04 13.6 1.3 0.076 12.7 0.4 1.8 1 1 1 2 2 2 0 Nitrile hydratase beta subunit EF-hand_6 PF13405.1 KOO53307.1 - 3.2e-13 48.3 2.0 8.3e-06 25.2 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO53307.1 - 2.4e-12 46.8 0.5 4.9e-12 45.8 0.3 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO53307.1 - 6.3e-12 43.8 4.7 4.5e-06 25.5 0.1 2.8 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO53307.1 - 5.7e-09 35.4 4.3 9.9e-05 21.8 0.0 3.0 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO53307.1 - 5.8e-09 34.8 5.9 0.00056 19.1 0.1 3.2 3 0 0 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.4 KOO53307.1 - 0.02 14.9 0.1 0.032 14.2 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region TPT PF03151.11 KOO53308.1 - 5.6e-17 61.7 7.3 5.6e-17 61.7 5.1 1.8 2 1 0 2 2 2 1 Triose-phosphate Transporter family CRT-like PF08627.5 KOO53308.1 - 0.049 13.5 0.2 0.15 12.0 0.1 1.8 2 0 0 2 2 2 0 CRT-like PHO4 PF01384.15 KOO53310.1 - 1.6e-09 36.9 1.7 1.6e-09 36.9 1.2 1.6 2 0 0 2 2 2 1 Phosphate transporter family SecY PF00344.15 KOO53310.1 - 0.054 12.4 0.3 0.058 12.3 0.2 1.1 1 0 0 1 1 1 0 SecY translocase FtsK_SpoIIIE PF01580.13 KOO53311.1 - 0.026 14.0 0.4 0.042 13.3 0.3 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family CbiN PF02553.10 KOO53311.1 - 0.13 12.2 2.9 0.3 11.1 1.0 2.3 2 1 0 2 2 2 0 Cobalt transport protein component CbiN Rax2 PF12768.2 KOO53311.1 - 0.14 11.3 0.8 0.22 10.6 0.5 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF3357 PF11837.3 KOO53311.1 - 0.18 11.6 1.5 0.57 10.0 1.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3357) CTP_transf_1 PF01148.15 KOO53312.1 - 1.4e-09 37.9 0.3 2.8e-09 37.0 0.1 1.5 2 0 0 2 2 2 1 Cytidylyltransferase family Methyltransf_24 PF13578.1 KOO53313.1 - 5.6e-05 23.9 0.0 9e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 KOO53313.1 - 0.025 14.0 0.0 0.04 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) HOOK PF05622.7 KOO53314.1 - 0.00036 18.4 4.6 0.00048 18.0 3.2 1.1 1 0 0 1 1 1 1 HOOK protein Myb_DNA-bind_6 PF13921.1 KOO53314.1 - 0.00059 19.8 0.0 0.015 15.4 0.0 2.5 2 0 0 2 2 2 1 Myb-like DNA-binding domain Spc7 PF08317.6 KOO53314.1 - 0.00079 18.1 4.1 0.0012 17.6 2.9 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein ATG16 PF08614.6 KOO53314.1 - 0.0013 18.6 6.8 0.0023 17.7 4.7 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Myosin_tail_1 PF01576.14 KOO53314.1 - 0.0018 16.1 7.9 0.0024 15.6 5.5 1.1 1 0 0 1 1 1 1 Myosin tail Filament PF00038.16 KOO53314.1 - 0.004 16.6 7.5 0.0058 16.1 5.2 1.1 1 0 0 1 1 1 1 Intermediate filament protein TMF_DNA_bd PF12329.3 KOO53314.1 - 0.0051 16.5 8.2 0.0051 16.5 5.7 2.4 1 1 0 2 2 2 1 TATA element modulatory factor 1 DNA binding YlqD PF11068.3 KOO53314.1 - 0.0071 16.3 3.3 0.014 15.4 2.3 1.4 1 0 0 1 1 1 1 YlqD protein IncA PF04156.9 KOO53314.1 - 0.008 15.8 9.0 0.025 14.1 6.2 1.8 1 1 0 1 1 1 1 IncA protein TBPIP PF07106.8 KOO53314.1 - 0.018 14.5 4.0 0.029 13.9 2.8 1.3 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) APG6 PF04111.7 KOO53314.1 - 0.028 13.4 6.7 0.041 12.9 4.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Striatin PF08232.7 KOO53314.1 - 0.029 14.7 0.3 0.029 14.7 0.2 1.7 2 0 0 2 2 1 0 Striatin family Leu_zip PF15294.1 KOO53314.1 - 0.037 13.1 8.0 0.06 12.4 5.5 1.2 1 0 0 1 1 1 0 Leucine zipper Herpes_UL6 PF01763.11 KOO53314.1 - 0.054 11.6 1.1 0.073 11.2 0.8 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like zf-C4H2 PF10146.4 KOO53314.1 - 0.056 13.4 0.4 0.1 12.6 0.2 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein TPR_MLP1_2 PF07926.7 KOO53314.1 - 0.07 12.8 8.0 0.14 11.8 5.6 1.5 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein ADIP PF11559.3 KOO53314.1 - 0.072 12.9 7.7 0.17 11.7 5.3 1.6 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding zf-BED PF02892.10 KOO53314.1 - 0.078 12.7 0.5 0.14 11.9 0.3 1.4 1 0 0 1 1 1 0 BED zinc finger Reo_sigmaC PF04582.7 KOO53314.1 - 0.085 12.0 0.4 0.12 11.5 0.3 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein ERM PF00769.14 KOO53314.1 - 0.11 12.0 12.7 1.1 8.7 8.8 2.0 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Tropomyosin_1 PF12718.2 KOO53314.1 - 0.11 12.3 11.6 0.17 11.6 7.6 1.7 1 1 0 1 1 1 0 Tropomyosin like Gag_spuma PF03276.9 KOO53314.1 - 0.12 10.7 3.2 0.17 10.2 2.2 1.1 1 0 0 1 1 1 0 Spumavirus gag protein DUF904 PF06005.7 KOO53314.1 - 0.12 12.6 5.7 0.44 10.8 2.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF904) TMF_TATA_bd PF12325.3 KOO53314.1 - 0.2 11.4 6.9 0.12 12.1 1.1 2.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding zf-C2H2 PF00096.21 KOO53314.1 - 0.22 11.9 0.6 0.38 11.1 0.4 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type V_ATPase_I PF01496.14 KOO53314.1 - 0.25 9.1 1.2 0.29 8.9 0.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fib_alpha PF08702.5 KOO53314.1 - 0.3 11.1 2.1 0.6 10.2 1.4 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family AAA_13 PF13166.1 KOO53314.1 - 0.33 9.3 6.7 0.53 8.6 4.7 1.2 1 0 0 1 1 1 0 AAA domain Atg14 PF10186.4 KOO53314.1 - 0.63 8.9 4.9 0.94 8.3 3.4 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Phage_GP20 PF06810.6 KOO53314.1 - 0.67 9.3 13.2 0.2 11.0 3.3 2.8 2 1 1 3 3 3 0 Phage minor structural protein GP20 Mnd1 PF03962.10 KOO53314.1 - 0.76 9.4 6.0 1.3 8.6 4.2 1.3 1 0 0 1 1 1 0 Mnd1 family DUF4140 PF13600.1 KOO53314.1 - 1 9.8 8.5 0.68 10.4 3.3 2.6 1 1 2 3 3 3 0 N-terminal domain of unknown function (DUF4140) DUF3090 PF11290.3 KOO53314.1 - 1.2 8.5 4.3 0.37 10.2 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3090) DUF641 PF04859.7 KOO53314.1 - 1.4 8.6 7.9 1.7 8.4 2.0 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Bap31 PF05529.7 KOO53314.1 - 2.5 7.5 9.1 3.7 6.9 5.7 1.7 1 1 1 2 2 2 0 B-cell receptor-associated protein 31-like DUF4407 PF14362.1 KOO53314.1 - 3.2 6.6 9.4 6 5.7 6.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) XhlA PF10779.4 KOO53314.1 - 4.6 7.2 5.7 10 6.1 4.0 1.7 1 0 0 1 1 1 0 Haemolysin XhlA FYDLN_acid PF09538.5 KOO53314.1 - 5 7.7 14.0 1 9.9 1.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DUF4200 PF13863.1 KOO53314.1 - 5.1 7.0 11.9 7.3 6.5 4.9 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Pkinase PF00069.20 KOO53315.1 - 2.3e-68 230.1 0.0 2.7e-68 229.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO53315.1 - 1.5e-33 116.0 0.0 1.8e-33 115.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO53315.1 - 3e-05 23.1 0.0 4.8e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 KOO53315.1 - 9.4e-05 21.5 0.0 0.00014 20.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.6 KOO53315.1 - 0.064 12.0 0.0 0.095 11.4 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase PF00069.20 KOO53316.1 - 1.5e-61 207.8 0.0 1.8e-61 207.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO53316.1 - 4.3e-20 71.8 0.0 6e-20 71.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO53316.1 - 1.6e-09 37.8 0.0 2.3e-06 27.5 0.1 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Choline_kinase PF01633.15 KOO53316.1 - 0.008 15.7 0.3 0.021 14.3 0.1 1.8 2 0 0 2 2 2 1 Choline/ethanolamine kinase RIO1 PF01163.17 KOO53316.1 - 0.038 13.3 0.1 0.071 12.4 0.0 1.4 1 1 0 1 1 1 0 RIO1 family Kdo PF06293.9 KOO53316.1 - 0.08 12.0 0.1 0.14 11.2 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family AAA_5 PF07728.9 KOO53317.1 - 1.3e-25 89.7 0.0 4.9e-17 61.9 0.0 2.3 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA PF00004.24 KOO53317.1 - 7.7e-12 45.5 0.1 0.00016 21.9 0.0 3.6 4 0 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) AAA_3 PF07726.6 KOO53317.1 - 1.3e-11 44.2 0.0 5.1e-10 39.0 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 KOO53317.1 - 1.8e-09 37.8 0.6 0.0014 18.6 0.1 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 KOO53317.1 - 8e-09 35.7 0.1 0.0028 17.8 0.0 2.6 2 1 0 2 2 2 2 AAA domain AAA_33 PF13671.1 KOO53317.1 - 3.2e-08 33.5 0.0 0.00038 20.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 KOO53317.1 - 6.4e-08 33.4 0.1 0.0032 18.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 KOO53317.1 - 8.1e-08 31.8 0.2 0.0068 15.8 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein Sigma54_activat PF00158.21 KOO53317.1 - 7.8e-07 28.7 0.0 0.01 15.3 0.0 2.9 3 0 0 3 3 3 2 Sigma-54 interaction domain AAA_18 PF13238.1 KOO53317.1 - 2.2e-06 27.9 0.1 0.037 14.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 KOO53317.1 - 4.1e-06 26.4 1.9 0.049 13.3 0.0 2.9 2 1 0 2 2 2 2 Part of AAA domain Zeta_toxin PF06414.7 KOO53317.1 - 4.5e-06 25.8 0.1 0.062 12.3 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin NACHT PF05729.7 KOO53317.1 - 4.8e-06 26.3 0.2 0.069 12.8 0.0 2.9 3 0 0 3 3 2 2 NACHT domain UPF0079 PF02367.12 KOO53317.1 - 6.3e-06 25.8 0.2 0.053 13.1 0.0 2.3 2 0 0 2 2 2 2 Uncharacterised P-loop hydrolase UPF0079 AAA_25 PF13481.1 KOO53317.1 - 1.8e-05 24.2 0.3 0.18 11.1 0.1 2.6 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.22 KOO53317.1 - 2.9e-05 24.4 0.0 0.0023 18.2 0.0 2.2 2 0 0 2 2 2 1 ABC transporter DUF258 PF03193.11 KOO53317.1 - 3.4e-05 23.0 0.0 0.12 11.5 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_30 PF13604.1 KOO53317.1 - 4.1e-05 23.2 0.1 0.17 11.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.16 KOO53317.1 - 5.1e-05 22.5 0.0 0.73 8.9 0.1 3.3 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.1 KOO53317.1 - 6.7e-05 22.9 0.7 0.053 13.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain T2SE PF00437.15 KOO53317.1 - 0.00015 20.7 0.1 0.45 9.3 0.0 2.7 2 1 0 3 3 3 2 Type II/IV secretion system protein Sigma54_activ_2 PF14532.1 KOO53317.1 - 0.00019 21.4 0.0 1.1 9.3 0.0 2.8 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_14 PF13173.1 KOO53317.1 - 0.00053 19.8 0.0 0.0085 15.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain Miro PF08477.8 KOO53317.1 - 0.0009 19.7 0.0 1.9 9.0 0.0 2.3 2 0 0 2 2 2 2 Miro-like protein CPT PF07931.7 KOO53317.1 - 0.0023 17.5 1.4 2.6 7.6 0.1 3.3 3 1 0 3 3 2 1 Chloramphenicol phosphotransferase-like protein PduV-EutP PF10662.4 KOO53317.1 - 0.0032 16.9 0.2 1.9 7.9 0.0 2.4 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation DUF815 PF05673.8 KOO53317.1 - 0.0033 16.4 0.1 0.077 11.9 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_24 PF13479.1 KOO53317.1 - 0.0037 16.8 0.0 1.2 8.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 KOO53317.1 - 0.0045 17.1 0.0 3.5 7.8 0.0 2.3 2 0 0 2 2 2 1 RNA helicase AAA_29 PF13555.1 KOO53317.1 - 0.0066 15.9 0.0 2.5 7.7 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain RuvB_N PF05496.7 KOO53317.1 - 0.0095 14.9 0.1 1.5 7.8 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus MMR_HSR1 PF01926.18 KOO53317.1 - 0.0097 15.8 0.0 2.9 7.8 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase PhoH PF02562.11 KOO53317.1 - 0.026 13.7 0.0 0.7 9.0 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein cobW PF02492.14 KOO53317.1 - 0.048 13.1 0.3 7.4 5.9 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Viral_helicase1 PF01443.13 KOO53317.1 - 0.053 13.0 0.0 4 6.9 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.1 KOO53317.1 - 0.057 13.7 0.0 6.9 6.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 KOO53317.1 - 0.21 11.2 0.0 2.9 7.5 0.0 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B SRP54 PF00448.17 KOO53317.1 - 0.23 10.8 0.1 2.8 7.3 0.0 2.1 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain ATP_bind_1 PF03029.12 KOO53317.1 - 0.31 10.5 0.2 9.1 5.7 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein EF-hand_7 PF13499.1 KOO53319.1 - 3.7e-27 94.2 2.1 1.2e-14 54.1 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 KOO53319.1 - 3.9e-23 78.9 6.5 4.3e-05 22.5 0.3 4.6 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.1 KOO53319.1 - 1.9e-20 71.1 8.3 4.3e-05 22.6 0.4 4.7 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO53319.1 - 2.6e-19 67.2 6.9 1.4e-05 24.6 0.0 4.8 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 KOO53319.1 - 1.3e-08 34.2 8.0 0.0065 16.0 0.5 4.1 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_4 PF12763.2 KOO53319.1 - 1.9e-05 24.3 0.1 0.0027 17.4 0.0 2.5 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand LRR_1 PF00560.28 KOO53319.1 - 2e-05 23.9 0.8 0.54 10.4 0.2 3.8 3 0 0 3 3 3 1 Leucine Rich Repeat LRR_8 PF13855.1 KOO53319.1 - 0.0002 21.0 0.3 0.0036 17.0 0.2 2.7 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.2 KOO53319.1 - 0.0019 17.7 0.2 0.039 13.5 0.2 2.4 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.1 KOO53319.1 - 0.0063 16.4 0.7 7 7.0 0.0 2.9 2 0 0 2 2 2 2 Leucine Rich repeat LRR_7 PF13504.1 KOO53319.1 - 0.007 16.3 0.9 1.3 9.4 0.4 3.4 3 0 0 3 3 2 1 Leucine rich repeat EF-hand_10 PF14788.1 KOO53319.1 - 0.0092 15.6 6.9 13 5.5 0.0 4.4 5 0 0 5 5 5 0 EF hand SPARC_Ca_bdg PF10591.4 KOO53319.1 - 0.065 13.2 0.0 1.2 9.1 0.0 2.9 1 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region TcdB_toxin_midN PF12256.3 KOO53319.1 - 0.15 11.4 0.0 24 4.3 0.0 2.6 2 0 0 2 2 2 0 Insecticide toxin TcdB middle/N-terminal region NAD_binding_10 PF13460.1 KOO53320.1 - 3.2e-17 63.1 0.1 6.1e-17 62.2 0.1 1.4 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 KOO53320.1 - 1.8e-15 56.8 0.0 4.3e-15 55.5 0.0 1.6 1 1 0 1 1 1 1 NmrA-like family adh_short PF00106.20 KOO53320.1 - 3.5e-06 27.0 0.0 0.0046 16.8 0.0 2.7 1 1 0 2 2 2 2 short chain dehydrogenase Epimerase PF01370.16 KOO53320.1 - 2.1e-05 24.0 0.0 4e-05 23.1 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 KOO53320.1 - 0.00016 20.4 0.0 0.00025 19.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.5 KOO53320.1 - 0.00023 20.8 0.0 0.038 13.6 0.0 2.5 1 1 1 2 2 2 1 KR domain Saccharop_dh PF03435.13 KOO53320.1 - 0.0079 15.2 0.0 0.013 14.5 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NAD_binding_4 PF07993.7 KOO53320.1 - 0.019 13.8 0.0 0.11 11.3 0.0 2.1 2 0 0 2 2 2 0 Male sterility protein RmlD_sub_bind PF04321.12 KOO53320.1 - 0.032 13.1 0.0 7.4 5.3 0.0 2.6 3 0 0 3 3 3 0 RmlD substrate binding domain Semialdhyde_dh PF01118.19 KOO53320.1 - 0.039 14.2 0.0 0.083 13.2 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DUF3456 PF11938.3 KOO53322.1 - 0.00028 20.9 14.0 0.025 14.5 0.5 3.9 3 1 1 4 4 4 2 TLR4 regulator and MIR-interacting MSAP DUF2075 PF09848.4 KOO53322.1 - 0.004 16.1 3.0 0.24 10.3 0.0 2.4 3 0 0 3 3 3 2 Uncharacterized conserved protein (DUF2075) SapB_1 PF05184.10 KOO53322.1 - 0.0083 15.9 1.0 11 6.0 0.0 3.5 3 0 0 3 3 3 1 Saposin-like type B, region 1 DUF445 PF04286.7 KOO53322.1 - 0.018 14.5 6.7 0.55 9.7 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF445) GLYCAM-1 PF05242.6 KOO53322.1 - 0.55 10.1 4.2 0.23 11.3 0.5 2.0 2 0 0 2 2 2 0 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) Tho2 PF11262.3 KOO53322.1 - 2.2 7.2 6.2 8.5 5.3 0.5 2.3 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 HrpB7 PF09486.5 KOO53323.1 - 0.002 18.0 17.6 0.002 18.0 12.2 2.9 2 1 1 3 3 2 1 Bacterial type III secretion protein (HrpB7) AAA_13 PF13166.1 KOO53323.1 - 0.0054 15.2 2.0 0.0074 14.8 1.4 1.1 1 0 0 1 1 1 1 AAA domain DUF3584 PF12128.3 KOO53323.1 - 0.013 12.8 10.6 0.016 12.5 7.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) HOOK PF05622.7 KOO53323.1 - 0.05 11.4 10.8 0.039 11.7 4.4 2.1 1 1 1 2 2 2 0 HOOK protein IFT57 PF10498.4 KOO53323.1 - 0.063 12.0 4.8 0.088 11.5 3.3 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 rRNA_proc-arch PF13234.1 KOO53323.1 - 0.082 12.0 2.5 4.6 6.3 0.6 2.2 1 1 1 2 2 2 0 rRNA-processing arch domain WEMBL PF05701.6 KOO53323.1 - 0.086 11.2 22.7 0.0071 14.8 6.5 2.0 1 1 1 2 2 2 0 Weak chloroplast movement under blue light APG6 PF04111.7 KOO53323.1 - 0.11 11.5 11.1 0.04 12.9 5.3 1.6 1 1 1 2 2 2 0 Autophagy protein Apg6 Spc7 PF08317.6 KOO53323.1 - 0.2 10.3 10.8 0.62 8.6 3.7 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.4 KOO53323.1 - 0.26 11.1 12.7 0.62 9.9 7.6 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Reo_sigmaC PF04582.7 KOO53323.1 - 0.36 9.9 3.1 0.74 8.9 1.9 1.6 1 1 0 1 1 1 0 Reovirus sigma C capsid protein Kinetocho_Slk19 PF12709.2 KOO53323.1 - 0.86 9.7 5.6 15 5.7 0.2 3.4 1 1 3 4 4 4 0 Central kinetochore-associated Laminin_II PF06009.7 KOO53323.1 - 1.5 8.6 9.4 0.91 9.2 4.4 2.2 1 1 0 1 1 1 0 Laminin Domain II FimP PF09766.4 KOO53323.1 - 1.9 7.4 7.2 1.3 8.0 0.6 2.1 1 1 1 2 2 2 0 Fms-interacting protein ATG16 PF08614.6 KOO53323.1 - 3.8 7.2 16.3 67 3.2 11.3 2.2 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) IncA PF04156.9 KOO53323.1 - 5.3 6.5 21.0 2.5 7.6 11.5 2.1 1 1 1 2 2 2 0 IncA protein ADIP PF11559.3 KOO53323.1 - 5.6 6.8 14.2 0.86 9.4 5.3 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding GAS PF13851.1 KOO53323.1 - 6.8 5.8 12.1 6.1 5.9 4.3 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Sigma70_ner PF04546.8 KOO53324.1 - 0.039 13.5 1.7 0.059 12.9 1.1 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region PBP1_TM PF14812.1 KOO53324.1 - 2.9 8.2 13.9 0.29 11.4 6.4 1.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CDC45 PF02724.9 KOO53324.1 - 4.3 5.2 8.5 5.9 4.7 5.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Shadoo PF14999.1 KOO53324.1 - 6.6 6.5 19.6 1.4 8.7 4.9 3.2 2 1 1 3 3 3 0 Shadow of prion protein, neuroprotective LRR_4 PF12799.2 KOO53325.1 - 1.9e-16 59.2 6.6 0.00015 21.2 0.1 5.8 4 2 3 7 7 7 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO53325.1 - 1.7e-11 43.6 13.8 0.0011 18.6 1.5 5.2 4 1 1 5 5 5 4 Leucine rich repeat LRR_6 PF13516.1 KOO53325.1 - 1.3e-06 27.8 9.7 0.69 10.1 0.0 6.4 6 1 1 7 7 7 4 Leucine Rich repeat LRR_1 PF00560.28 KOO53325.1 - 0.0002 20.9 13.2 1.3 9.3 0.4 6.8 5 3 1 6 6 6 2 Leucine Rich Repeat LRR_9 PF14580.1 KOO53325.1 - 0.0086 15.6 2.7 0.17 11.4 0.0 2.8 2 1 2 4 4 4 1 Leucine-rich repeat LRR_7 PF13504.1 KOO53325.1 - 0.015 15.3 18.6 11 6.7 0.0 7.8 8 1 1 9 9 9 0 Leucine rich repeat EF-hand_1 PF00036.27 KOO53326.1 - 9.9e-34 112.0 9.4 9e-05 21.5 0.1 6.6 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.1 KOO53326.1 - 6.4e-33 109.6 9.8 0.0001 21.8 0.0 6.5 6 0 0 6 6 6 6 EF-hand domain EF-hand_7 PF13499.1 KOO53326.1 - 3.5e-27 94.3 7.6 7.2e-08 32.4 0.1 4.3 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 KOO53326.1 - 1.5e-18 65.2 8.7 0.0019 17.4 0.8 6.5 6 0 0 6 6 6 6 EF hand EF-hand_8 PF13833.1 KOO53326.1 - 4.4e-18 64.6 11.0 0.004 16.7 0.0 6.2 3 3 3 6 6 6 6 EF-hand domain pair EF-hand_10 PF14788.1 KOO53326.1 - 0.00055 19.5 1.8 4.2 7.0 0.0 4.5 5 1 1 6 6 6 2 EF hand DUF3530 PF12048.3 KOO53326.1 - 0.03 13.3 0.1 0.052 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Ion_trans PF00520.26 KOO53327.1 - 1.4e-12 47.3 5.5 3.7e-12 45.9 3.8 1.7 1 1 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.11 KOO53327.1 - 2.8e-07 30.1 2.3 2.8e-07 30.1 1.6 2.9 4 0 0 4 4 4 1 Ion channel Rootletin PF15035.1 KOO53327.1 - 0.00028 20.9 0.0 0.0008 19.4 0.0 1.7 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion Chloroa_b-bind PF00504.16 KOO53329.1 - 4.4e-29 101.7 0.2 1.2e-23 84.0 0.0 2.0 1 1 1 2 2 2 2 Chlorophyll A-B binding protein DUF812 PF05667.6 KOO53331.1 - 0.056 11.9 4.8 0.068 11.6 3.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF2383 PF09537.5 KOO53331.1 - 0.084 13.1 2.5 0.12 12.6 1.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) DDE_Tnp_1_6 PF13751.1 KOO53331.1 - 0.13 12.2 1.2 0.16 11.9 0.9 1.2 1 0 0 1 1 1 0 Transposase DDE domain Beta_helix PF13229.1 KOO53333.1 - 3.4e-07 30.1 0.7 3.9e-07 29.9 0.5 1.1 1 0 0 1 1 1 1 Right handed beta helix region Chlam_PMP PF02415.12 KOO53333.1 - 0.14 12.4 7.4 0.83 10.0 0.3 2.8 3 0 0 3 3 3 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat DUF4340 PF14238.1 KOO53333.1 - 0.67 9.6 2.1 4.4 6.9 1.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4340) VacA2 PF03077.9 KOO53333.1 - 2.6 7.7 11.5 0.3 10.7 1.6 2.3 1 1 1 2 2 2 0 Putative vacuolating cytotoxin Esterase_phd PF10503.4 KOO53336.1 - 0.00047 19.4 6.8 0.0037 16.5 4.6 2.4 2 1 0 2 2 2 1 Esterase PHB depolymerase Gram_pos_anchor PF00746.16 KOO53336.1 - 1.9 8.3 7.9 0.079 12.7 1.4 1.7 2 0 0 2 2 2 0 Gram positive anchor MFS_1 PF07690.11 KOO53337.1 - 1.9e-18 66.3 27.5 2.5e-18 65.9 19.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Gln-synt_C PF00120.19 KOO53340.1 - 1.5e-61 207.8 0.0 1.8e-61 207.5 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.14 KOO53340.1 - 3.4e-16 58.5 0.0 7.9e-16 57.4 0.0 1.6 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Activator_LAG-3 PF11498.3 KOO53343.1 - 0.96 8.1 5.5 1.5 7.5 3.8 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Nup54 PF13874.1 KOO53344.1 - 2.9e-07 30.2 6.0 2.9e-07 30.2 4.2 1.9 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 CdhD PF03599.11 KOO53344.1 - 0.035 12.6 0.7 0.06 11.8 0.2 1.5 1 1 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit BTB PF00651.26 KOO53344.1 - 6 6.8 7.6 6.1 6.8 0.4 3.2 1 1 1 2 2 2 0 BTB/POZ domain TPR_16 PF13432.1 KOO53345.1 - 0.0056 17.3 0.3 0.099 13.3 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 KOO53345.1 - 0.054 13.1 0.1 1.1 8.8 0.0 2.4 2 0 0 2 2 2 0 TPR repeat Armet PF10208.4 KOO53346.1 - 0.03 13.9 0.3 0.05 13.2 0.2 1.3 1 0 0 1 1 1 0 Degradation arginine-rich protein for mis-folding APC_CDC26 PF10471.4 KOO53346.1 - 0.16 12.7 2.3 0.33 11.7 1.6 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit 1 IncA PF04156.9 KOO53346.1 - 1.2 8.6 6.3 2 7.9 4.3 1.3 1 0 0 1 1 1 0 IncA protein OmpH PF03938.9 KOO53346.1 - 6.1 6.7 10.3 9.9 6.0 7.1 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TPR_11 PF13414.1 KOO53347.1 - 5.3e-58 192.5 42.8 1.1e-13 50.5 0.7 10.7 8 2 3 11 11 11 9 TPR repeat TPR_2 PF07719.12 KOO53347.1 - 1.3e-35 118.4 46.1 0.00036 20.2 0.1 15.3 15 0 0 15 15 15 9 Tetratricopeptide repeat TPR_1 PF00515.23 KOO53347.1 - 2e-35 118.9 21.1 1.8e-05 24.1 0.0 13.8 15 0 0 15 15 15 8 Tetratricopeptide repeat Cullin_binding PF03556.10 KOO53347.1 - 8.6e-25 87.1 0.1 1.6e-24 86.3 0.0 1.4 1 0 0 1 1 1 1 Cullin binding TPR_16 PF13432.1 KOO53347.1 - 1.1e-17 64.2 71.5 0.00097 19.7 4.8 11.8 9 2 2 11 11 11 6 Tetratricopeptide repeat TPR_12 PF13424.1 KOO53347.1 - 1.5e-11 44.0 45.3 0.019 14.9 0.8 9.9 6 3 5 11 11 11 7 Tetratricopeptide repeat TPR_14 PF13428.1 KOO53347.1 - 2.6e-10 40.0 70.4 0.034 14.7 0.1 15.2 7 4 8 16 16 15 8 Tetratricopeptide repeat Phosducin PF02114.11 KOO53347.1 - 4.9e-10 38.5 0.1 1.8e-09 36.6 0.1 1.8 1 1 0 1 1 1 1 Phosducin TPR_8 PF13181.1 KOO53347.1 - 6.4e-10 38.0 11.4 0.79 9.6 0.0 10.7 14 0 0 14 14 13 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOO53347.1 - 1.2e-09 38.2 33.0 0.019 15.2 1.0 9.2 5 4 5 10 10 10 4 Tetratricopeptide repeat TPR_17 PF13431.1 KOO53347.1 - 1.8e-05 24.5 25.6 0.2 11.9 0.0 10.9 12 1 1 13 13 12 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO53347.1 - 0.00071 19.3 44.2 0.28 11.0 0.4 9.3 6 4 3 9 9 8 6 Tetratricopeptide repeat TPR_7 PF13176.1 KOO53347.1 - 0.0012 18.4 18.1 1.7 8.6 0.0 8.7 10 1 0 10 10 9 2 Tetratricopeptide repeat FAT PF02259.18 KOO53347.1 - 0.0025 16.8 6.8 0.3 10.0 0.2 4.1 3 1 1 4 4 4 1 FAT domain TPR_20 PF14561.1 KOO53347.1 - 0.013 15.5 22.8 0.48 10.5 0.0 6.6 5 1 1 6 6 6 0 Tetratricopeptide repeat DUF4250 PF14056.1 KOO53347.1 - 0.096 12.4 0.0 0.24 11.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) DUF788 PF05620.6 KOO53348.1 - 5.1e-34 117.5 1.7 5.9e-34 117.3 1.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF788) zf-AN1 PF01428.11 KOO53349.1 - 3.2e-10 39.7 7.9 3.2e-10 39.7 5.5 1.9 2 0 0 2 2 2 1 AN1-like Zinc finger zf-A20 PF01754.11 KOO53349.1 - 4e-10 39.0 6.0 9e-10 37.9 4.1 1.7 1 0 0 1 1 1 1 A20-like zinc finger MCPVI PF02993.9 KOO53349.1 - 1.9 8.5 8.4 2.5 8.1 5.8 1.1 1 0 0 1 1 1 0 Minor capsid protein VI Glyco_transf_25 PF01755.12 KOO53350.1 - 6.5e-05 22.6 0.0 0.00099 18.7 0.0 2.3 2 1 0 3 3 3 1 Glycosyltransferase family 25 (LPS biosynthesis protein) DUF21 PF01595.15 KOO53351.1 - 2.1e-34 118.4 3.1 3.3e-34 117.7 2.2 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF21 CBS PF00571.23 KOO53351.1 - 7.2e-09 35.2 0.2 0.0001 21.9 0.0 2.7 2 0 0 2 2 2 2 CBS domain PagP PF07017.6 KOO53351.1 - 0.072 12.4 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Antimicrobial peptide resistance and lipid A acylation protein PagP Glt_symporter PF03616.9 KOO53351.1 - 0.46 8.9 6.4 0.1 11.0 0.3 2.1 2 0 0 2 2 2 0 Sodium/glutamate symporter IBR PF01485.16 KOO53352.1 - 1.3e-09 37.7 0.9 1.3e-09 37.7 0.6 3.4 2 1 1 3 3 3 2 IBR domain zf-Nse PF11789.3 KOO53352.1 - 0.0037 16.7 0.4 0.51 9.8 0.0 3.1 2 1 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit C1_4 PF07975.7 KOO53352.1 - 0.034 14.1 3.6 0.034 14.1 2.5 3.1 2 1 0 2 2 2 0 TFIIH C1-like domain zf-RING_2 PF13639.1 KOO53352.1 - 0.74 9.7 27.1 0.04 13.7 8.3 2.7 2 1 0 2 2 2 0 Ring finger domain zf-C3HC4 PF00097.20 KOO53352.1 - 0.9 9.2 27.3 0.47 10.1 7.9 3.2 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO53352.1 - 5.9 6.7 28.2 1.8 8.3 10.1 2.6 2 1 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_4 PF15227.1 KOO53352.1 - 6.5 6.7 17.7 2.2 8.2 1.8 3.5 3 1 1 4 4 4 0 zinc finger of C3HC4-type, RING PIF1 PF05970.9 KOO53353.1 - 8.3e-20 71.0 0.0 9.9e-20 70.7 0.0 1.0 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.1 KOO53353.1 - 6.6e-09 35.6 0.1 8.5e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 KOO53353.1 - 6.1e-06 25.5 0.1 9e-06 24.9 0.1 1.2 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.1 KOO53353.1 - 0.00095 19.3 0.0 0.0018 18.3 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 KOO53353.1 - 0.0089 16.0 0.3 0.042 13.8 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain DEAD PF00270.24 KOO53353.1 - 0.012 15.1 0.2 0.38 10.2 0.0 2.1 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_25 PF13481.1 KOO53353.1 - 0.062 12.7 0.1 0.16 11.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain PhoH PF02562.11 KOO53353.1 - 0.11 11.7 0.1 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Helicase_RecD PF05127.9 KOO53353.1 - 0.11 12.0 0.6 14 5.2 0.0 2.2 2 0 0 2 2 2 0 Helicase ABC_tran PF00005.22 KOO53353.1 - 0.12 12.7 0.0 0.61 10.3 0.0 2.0 2 0 0 2 2 2 0 ABC transporter AAA_5 PF07728.9 KOO53353.1 - 0.15 11.7 0.2 1.1 9.0 0.2 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 KOO53353.1 - 0.59 9.5 3.2 1.5 8.1 0.0 2.5 1 1 1 2 2 2 0 IstB-like ATP binding protein Homeobox PF00046.24 KOO53355.1 - 2e-08 33.7 0.1 5.2e-08 32.3 0.1 1.7 1 0 0 1 1 1 1 Homeobox domain Acetyltransf_1 PF00583.19 KOO53356.1 - 1.2e-05 25.2 0.0 2e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 KOO53356.1 - 0.00075 19.6 0.0 0.0014 18.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 KOO53356.1 - 0.013 15.1 0.0 0.027 14.2 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Anoctamin PF04547.7 KOO53357.1 - 3.9e-85 286.1 0.0 6.1e-85 285.5 0.0 1.3 1 0 0 1 1 1 1 Calcium-activated chloride channel DUF2360 PF10152.4 KOO53357.1 - 0.74 10.0 5.0 1.3 9.3 3.5 1.3 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) DnaJ PF00226.26 KOO53359.1 - 1.2e-09 37.8 0.1 2.3e-09 36.8 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain DUF2188 PF09954.4 KOO53359.1 - 0.66 9.9 0.1 0.66 9.9 0.0 3.1 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2188) DUF3359 PF11839.3 KOO53359.1 - 6.7 7.1 13.3 1.6 9.1 6.7 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3359) DEAD PF00270.24 KOO53361.1 - 4.3e-07 29.5 0.1 8.3e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 KOO53361.1 - 8.9e-06 25.8 0.2 2.1e-05 24.6 0.1 1.6 1 1 0 1 1 1 1 AAA domain ResIII PF04851.10 KOO53361.1 - 0.00032 20.5 0.0 0.33 10.7 0.0 2.3 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit T2SE PF00437.15 KOO53361.1 - 0.00068 18.6 0.1 0.0058 15.5 0.0 2.0 2 0 0 2 2 2 1 Type II/IV secretion system protein Sigma54_activ_2 PF14532.1 KOO53361.1 - 0.0036 17.3 0.0 0.011 15.8 0.0 1.8 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_14 PF13173.1 KOO53361.1 - 0.0055 16.6 0.1 0.051 13.4 0.1 2.1 1 1 0 1 1 1 1 AAA domain SRP54 PF00448.17 KOO53361.1 - 0.0072 15.7 0.2 0.013 14.9 0.1 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain Flavi_DEAD PF07652.9 KOO53361.1 - 0.0085 15.8 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain cobW PF02492.14 KOO53361.1 - 0.016 14.6 0.1 0.32 10.4 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_19 PF13245.1 KOO53361.1 - 0.036 13.8 0.0 0.084 12.6 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain NB-ARC PF00931.17 KOO53361.1 - 0.055 12.3 0.0 0.077 11.8 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_25 PF13481.1 KOO53361.1 - 0.061 12.7 0.1 0.2 11.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.1 KOO53361.1 - 0.065 13.1 1.9 0.081 12.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.22 KOO53361.1 - 0.072 13.3 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.1 KOO53361.1 - 0.083 12.4 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_activat PF00158.21 KOO53361.1 - 0.088 12.2 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain KaiC PF06745.8 KOO53361.1 - 0.095 11.8 0.0 0.19 10.7 0.0 1.5 1 0 0 1 1 1 0 KaiC Zeta_toxin PF06414.7 KOO53361.1 - 0.11 11.5 0.2 0.66 9.0 0.0 2.1 1 1 1 2 2 2 0 Zeta toxin AAA_23 PF13476.1 KOO53361.1 - 0.2 11.9 0.0 0.35 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 KOO53361.1 - 0.34 11.2 0.1 0.34 11.2 0.0 2.5 2 2 0 2 2 2 0 AAA domain Methyltransf_PK PF05891.7 KOO53362.1 - 7.5e-55 185.5 0.0 8.7e-55 185.3 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.1 KOO53362.1 - 1.4e-11 44.6 0.0 2.1e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO53362.1 - 3.3e-11 43.5 0.0 5.3e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO53362.1 - 5.5e-11 43.0 0.1 8.9e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO53362.1 - 7.2e-10 39.2 0.0 1.1e-09 38.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO53362.1 - 8.3e-09 35.3 0.0 1.1e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO53362.1 - 7.9e-08 32.3 0.3 1.5e-07 31.4 0.2 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 KOO53362.1 - 2.7e-06 26.7 0.0 3.6e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_31 PF13847.1 KOO53362.1 - 1.3e-05 24.7 0.0 1.8e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOO53362.1 - 5.1e-05 22.7 0.0 8.3e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.13 KOO53362.1 - 0.007 15.5 0.0 0.0099 15.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Nif11 PF07862.6 KOO53362.1 - 0.05 13.5 0.0 0.14 12.0 0.0 1.8 1 0 0 1 1 1 0 Nitrogen fixation protein of unknown function CheR PF01739.13 KOO53362.1 - 0.074 12.3 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain DUF4072 PF13284.1 KOO53362.1 - 0.13 12.4 1.9 1.6 8.9 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4072) cNMP_binding PF00027.24 KOO53364.1 - 0.027 14.2 0.0 0.045 13.5 0.0 1.4 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain SNARE PF05739.14 KOO53365.1 - 0.00024 20.7 0.2 0.00024 20.7 0.2 1.4 2 0 0 2 2 2 1 SNARE domain Phage_Gp23 PF10669.4 KOO53365.1 - 0.13 12.4 0.1 0.13 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Cir_N PF10197.4 KOO53366.1 - 2.2e-10 40.3 4.2 2.2e-10 40.3 2.9 3.0 4 0 0 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR zf-CCHC_6 PF15288.1 KOO53366.1 - 0.011 15.4 0.2 0.022 14.3 0.1 1.6 1 0 0 1 1 1 0 Zinc knuckle Cas_Cas5d PF09704.5 KOO53366.1 - 0.089 12.3 0.9 5.5 6.5 0.0 3.0 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Cas5) RNase_PH PF01138.16 KOO53367.1 - 1.7e-31 109.2 0.0 2.2e-31 108.8 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 KOO53367.1 - 9.5e-07 28.6 0.1 2.3e-06 27.4 0.0 1.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 CBM_2 PF00553.14 KOO53368.1 - 0.0049 16.8 9.2 0.13 12.3 0.2 3.0 4 0 0 4 4 4 2 Cellulose binding domain Pea-VEAacid PF08111.6 KOO53368.1 - 0.13 12.3 0.2 37 4.7 0.0 2.9 2 0 0 2 2 2 0 Pea-VEAacid family Mito_fiss_reg PF05308.6 KOO53369.1 - 0.33 10.2 4.1 0.46 9.8 2.8 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.14 KOO53369.1 - 1.2 8.3 3.4 1.6 7.9 2.3 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Glyco_hydro_7 PF00840.15 KOO53370.1 - 3.7e-16 58.5 0.2 4e-16 58.4 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 DDE_Tnp_4 PF13359.1 KOO53371.1 - 2.3e-13 50.0 0.0 3.5e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease Glyco_transf_15 PF01793.11 KOO53373.1 - 3.5e-31 108.3 0.0 7.2e-31 107.3 0.0 1.4 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase TPR_11 PF13414.1 KOO53373.1 - 2e-26 91.4 11.8 3.6e-08 32.9 1.1 5.4 4 1 1 5 5 5 5 TPR repeat TPR_1 PF00515.23 KOO53373.1 - 1.6e-19 68.6 2.5 0.00021 20.7 0.0 7.7 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.12 KOO53373.1 - 1.9e-19 67.9 13.5 0.0028 17.4 0.0 8.1 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_7 PF13176.1 KOO53373.1 - 1e-16 59.3 3.8 0.0024 17.5 0.0 6.2 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.1 KOO53373.1 - 1.4e-16 60.6 33.8 2.1e-07 31.4 2.5 6.0 3 3 1 5 5 5 5 Tetratricopeptide repeat TPR_12 PF13424.1 KOO53373.1 - 1.7e-15 56.6 14.8 1.8e-10 40.6 1.2 5.0 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOO53373.1 - 6.5e-13 48.8 9.6 0.00093 19.4 0.1 5.0 2 2 3 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.1 KOO53373.1 - 8.9e-11 40.7 0.1 0.00013 21.5 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO53373.1 - 2.2e-10 40.2 23.1 0.069 13.8 0.2 7.7 3 2 4 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.1 KOO53373.1 - 1.6e-06 27.8 7.3 0.74 10.1 0.0 6.7 7 0 0 7 7 7 1 Tetratricopeptide repeat Apc3 PF12895.2 KOO53373.1 - 2.4e-05 24.3 0.1 0.4 10.8 0.0 3.4 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.1 KOO53373.1 - 7.8e-05 22.4 21.6 0.0046 16.8 0.2 6.3 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.1 KOO53373.1 - 0.00036 20.3 4.2 0.58 10.0 0.8 4.3 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 KOO53373.1 - 0.015 15.7 11.0 2.8 8.6 0.0 5.8 7 0 0 7 7 5 0 Tetratricopeptide repeat MIT PF04212.13 KOO53373.1 - 3.7 7.4 8.4 20 5.1 0.1 3.8 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain Laminin_G_3 PF13385.1 KOO53374.1 - 1.8e-16 60.8 0.2 2.1e-16 60.5 0.1 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tropomyosin PF00261.15 KOO53375.1 - 0.0027 16.8 4.2 0.0027 16.8 2.9 3.8 1 1 3 4 4 4 2 Tropomyosin T2SM_b PF10741.4 KOO53375.1 - 0.0039 16.7 1.1 0.0039 16.7 0.7 3.5 2 2 1 3 3 3 1 Type II secretion system (T2SS), protein M subtype b Zein-binding PF04576.10 KOO53375.1 - 0.011 15.8 6.1 0.011 15.8 4.2 5.0 5 1 0 5 5 5 0 Zein-binding AAA_13 PF13166.1 KOO53375.1 - 0.12 10.7 13.7 1.2 7.5 6.0 2.1 1 1 1 2 2 2 0 AAA domain Fib_alpha PF08702.5 KOO53375.1 - 0.17 11.9 7.5 0.59 10.2 0.1 2.4 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Filament PF00038.16 KOO53375.1 - 1.3 8.4 24.9 1.4e+02 1.7 17.2 2.7 1 1 0 1 1 1 0 Intermediate filament protein DUF904 PF06005.7 KOO53375.1 - 1.9 8.8 17.4 6.2 7.1 0.6 4.5 3 1 1 4 4 4 0 Protein of unknown function (DUF904) HAUS-augmin3 PF14932.1 KOO53375.1 - 3.9 6.5 29.2 0.059 12.5 2.9 2.7 2 1 0 3 3 3 0 HAUS augmin-like complex subunit 3 Mnd1 PF03962.10 KOO53375.1 - 8.8 5.9 19.1 5.3 6.6 3.7 3.1 1 1 1 2 2 2 0 Mnd1 family Racemase_4 PF13615.1 KOO53376.1 - 2.9e-21 75.6 0.0 5.7e-21 74.6 0.0 1.5 1 0 0 1 1 1 1 Putative alanine racemase MCM_bind PF09739.4 KOO53376.1 - 1e-09 37.9 0.0 1.6e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Mini-chromosome maintenance replisome factor PH PF00169.24 KOO53377.1 - 8.3e-10 38.8 0.0 0.0001 22.4 0.0 2.3 2 0 0 2 2 2 2 PH domain PH_11 PF15413.1 KOO53377.1 - 7.9e-06 26.0 0.0 0.0022 18.2 0.0 2.7 2 1 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.1 KOO53377.1 - 0.0031 17.5 0.0 2.2 8.4 0.0 2.2 2 0 0 2 2 2 2 Pleckstrin homology domain Kinesin PF00225.18 KOO53378.1 - 2.5e-36 125.0 0.0 4.2e-36 124.3 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain F420_oxidored PF03807.12 KOO53379.1 - 3.8e-11 43.2 0.0 7.3e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent EF-hand_1 PF00036.27 KOO53379.1 - 4.5e-11 41.2 0.1 0.0001 21.3 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO53379.1 - 5.1e-08 32.4 0.6 0.00011 21.7 0.1 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.1 KOO53379.1 - 2.2e-07 30.9 0.0 3.6e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO53379.1 - 1.1e-06 28.0 0.0 0.028 14.2 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO53379.1 - 3e-06 26.3 0.0 0.0071 15.6 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.2 KOO53379.1 - 0.0086 15.8 0.0 0.71 9.6 0.0 2.3 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand NAD_binding_2 PF03446.10 KOO53379.1 - 0.012 15.4 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.14 KOO53379.1 - 0.013 14.6 0.0 0.033 13.3 0.0 1.7 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain EF-hand_9 PF14658.1 KOO53379.1 - 0.043 13.7 0.0 0.065 13.1 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain Shikimate_DH PF01488.15 KOO53379.1 - 0.066 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.13 KOO53379.1 - 1 8.9 5.1 0.62 9.6 0.1 2.3 2 1 1 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain APG6 PF04111.7 KOO53380.1 - 0.0049 15.9 16.4 0.0063 15.5 11.3 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 IFT57 PF10498.4 KOO53380.1 - 0.0051 15.6 8.7 0.006 15.3 6.1 1.0 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 GlnE PF03710.10 KOO53380.1 - 0.0092 15.2 13.3 0.03 13.5 3.1 2.0 2 0 0 2 2 2 2 Glutamate-ammonia ligase adenylyltransferase Nup54 PF13874.1 KOO53380.1 - 0.013 15.1 3.6 0.013 15.1 2.5 2.2 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 NPV_P10 PF05531.7 KOO53380.1 - 0.021 15.0 5.5 0.88 9.8 0.4 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Cluap1 PF10234.4 KOO53380.1 - 0.039 13.1 11.6 0.048 12.8 8.0 1.1 1 0 0 1 1 1 0 Clusterin-associated protein-1 FimP PF09766.4 KOO53380.1 - 0.076 12.0 7.8 0.097 11.7 5.4 1.2 1 0 0 1 1 1 0 Fms-interacting protein Mnd1 PF03962.10 KOO53380.1 - 0.081 12.5 19.8 0.32 10.6 6.8 2.0 1 1 1 2 2 2 0 Mnd1 family GHL13 PF14883.1 KOO53380.1 - 0.11 11.6 6.1 0.14 11.3 4.2 1.2 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 13 IncA PF04156.9 KOO53380.1 - 0.15 11.6 18.5 0.37 10.3 12.8 1.6 1 1 0 1 1 1 0 IncA protein IFT46_B_C PF12317.3 KOO53380.1 - 0.16 11.3 2.8 0.18 11.1 1.9 1.1 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal DUF2096 PF09869.4 KOO53380.1 - 0.19 11.6 6.6 0.85 9.4 4.5 1.9 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2096) DivIVA PF05103.8 KOO53380.1 - 0.23 11.5 20.9 0.14 12.2 7.7 2.3 1 1 1 2 2 2 0 DivIVA protein DUF4201 PF13870.1 KOO53380.1 - 0.33 10.3 11.1 1.2 8.4 0.8 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) zf-C4H2 PF10146.4 KOO53380.1 - 0.36 10.8 6.0 0.24 11.4 2.8 1.6 1 1 0 1 1 1 0 Zinc finger-containing protein CALCOCO1 PF07888.6 KOO53380.1 - 0.54 8.4 15.8 0.69 8.1 10.9 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like AAA_13 PF13166.1 KOO53380.1 - 0.6 8.4 11.0 0.73 8.2 7.7 1.1 1 0 0 1 1 1 0 AAA domain GAS PF13851.1 KOO53380.1 - 0.68 9.0 15.5 3 7.0 10.6 2.0 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding GNT-I PF03071.10 KOO53380.1 - 0.7 8.3 4.8 0.78 8.2 3.3 1.1 1 0 0 1 1 1 0 GNT-I family Mer2 PF09074.5 KOO53380.1 - 0.87 9.4 9.4 2.3 8.0 6.5 1.7 1 1 0 1 1 1 0 Mer2 Acetyltransf_11 PF13720.1 KOO53380.1 - 0.92 9.7 8.2 0.12 12.5 1.3 2.4 1 1 2 3 3 3 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Baculo_PEP_C PF04513.7 KOO53380.1 - 1.4 8.7 8.5 17 5.2 0.6 2.6 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Reo_sigmaC PF04582.7 KOO53380.1 - 1.5 7.9 6.3 2.5 7.2 4.4 1.4 1 1 0 1 1 1 0 Reovirus sigma C capsid protein DUF4200 PF13863.1 KOO53380.1 - 2.5 8.0 22.2 0.31 10.9 9.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Mob_synth_C PF06463.8 KOO53380.1 - 2.5 7.8 5.8 2.8 7.6 0.6 2.5 1 1 1 2 2 2 0 Molybdenum Cofactor Synthesis C Cupin_4 PF08007.7 KOO53380.1 - 4.6 6.3 7.8 7 5.7 5.4 1.4 1 1 0 1 1 1 0 Cupin superfamily protein DUF972 PF06156.8 KOO53380.1 - 5 7.5 11.8 7.8 6.9 4.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Atg14 PF10186.4 KOO53380.1 - 5.2 5.9 14.4 8.8 5.1 10.0 1.4 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Mod_r PF07200.8 KOO53380.1 - 5.9 6.7 17.2 22 4.9 6.2 2.1 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF2408 PF10303.4 KOO53380.1 - 6.5 6.8 6.2 18 5.4 4.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) Spc7 PF08317.6 KOO53380.1 - 6.5 5.3 14.0 13 4.3 9.7 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein Muted PF14942.1 KOO53380.1 - 6.6 6.5 11.5 15 5.4 7.8 1.6 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein ERM PF00769.14 KOO53380.1 - 7.2 6.0 28.6 11 5.3 19.8 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Spc24 PF08286.6 KOO53380.1 - 7.4 6.3 12.7 3.7 7.2 1.8 2.3 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DUF812 PF05667.6 KOO53380.1 - 9.7 4.5 19.3 22 3.3 13.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF812) DUF342 PF03961.8 KOO53380.1 - 9.8 4.4 9.9 16 3.7 6.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Cys_rich_CPXG PF14255.1 KOO53381.1 - 0.13 12.1 0.2 20 5.1 0.1 2.6 2 0 0 2 2 2 0 Cysteine-rich CPXCG NACHT PF05729.7 KOO53383.1 - 1.4e-06 28.0 0.1 2.9e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 NACHT domain DUF4150 PF13665.1 KOO53383.1 - 0.0079 16.0 0.1 0.018 14.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4150) KAT11 PF08214.6 KOO53384.1 - 1.4e-32 113.1 0.0 1.9e-32 112.7 0.0 1.2 1 0 0 1 1 1 1 Histone acetylation protein PHD PF00628.24 KOO53384.1 - 2.3e-05 23.9 5.1 2.3e-05 23.9 3.6 3.0 2 0 0 2 2 2 1 PHD-finger SUR7 PF06687.7 KOO53387.1 - 0.21 11.1 6.0 0.32 10.5 4.2 1.2 1 0 0 1 1 1 0 SUR7/PalI family Pkinase PF00069.20 KOO53390.1 - 2.3e-57 194.1 0.0 3e-57 193.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.24 KOO53390.1 - 4.5e-53 177.0 0.8 7e-19 67.4 0.0 3.6 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.12 KOO53390.1 - 1.3e-31 109.6 0.0 1.8e-31 109.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO53390.1 - 2e-06 26.9 0.0 3.5e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO53390.1 - 0.00021 21.0 0.0 0.00047 19.9 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 KOO53390.1 - 0.031 13.3 0.0 0.051 12.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 KOO53390.1 - 0.036 12.8 0.0 0.058 12.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Choline_kinase PF01633.15 KOO53390.1 - 0.15 11.6 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase AAA PF00004.24 KOO53391.1 - 1.7e-14 54.1 0.0 3.3e-14 53.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOO53391.1 - 4.6e-06 26.7 0.4 6.3e-05 23.1 0.0 2.8 3 1 0 3 3 2 1 AAA domain AAA_19 PF13245.1 KOO53391.1 - 2e-05 24.2 0.2 0.00035 20.2 0.1 2.8 2 0 0 2 2 2 1 Part of AAA domain AAA_18 PF13238.1 KOO53391.1 - 0.00011 22.4 0.1 0.00039 20.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 KOO53391.1 - 0.00024 21.9 0.8 0.001 19.8 0.1 2.2 1 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 KOO53391.1 - 0.00068 19.5 0.1 0.0018 18.1 0.1 1.8 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.5 KOO53391.1 - 0.0011 18.2 0.0 0.0017 17.6 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 MobB PF03205.9 KOO53391.1 - 0.0012 18.5 0.1 0.0024 17.6 0.1 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B DUF853 PF05872.7 KOO53391.1 - 0.0021 16.4 0.2 0.0031 15.9 0.1 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF853) AAA_5 PF07728.9 KOO53391.1 - 0.0024 17.6 0.2 0.0072 16.0 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 KOO53391.1 - 0.0033 17.4 4.5 0.0064 16.5 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain AAA_28 PF13521.1 KOO53391.1 - 0.006 16.5 0.3 0.018 14.9 0.2 2.1 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 KOO53391.1 - 0.008 15.2 0.0 0.027 13.5 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_30 PF13604.1 KOO53391.1 - 0.0098 15.4 1.6 0.024 14.1 0.2 2.4 2 1 0 2 2 2 1 AAA domain APS_kinase PF01583.15 KOO53391.1 - 0.03 13.9 0.0 0.063 12.9 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase Thymidylate_kin PF02223.12 KOO53391.1 - 0.037 13.4 0.1 0.11 11.8 0.0 1.8 1 0 0 1 1 1 0 Thymidylate kinase NTPase_1 PF03266.10 KOO53391.1 - 0.037 13.7 0.0 0.085 12.5 0.0 1.6 1 0 0 1 1 1 0 NTPase AAA_10 PF12846.2 KOO53391.1 - 0.048 13.0 0.1 0.43 9.9 0.1 2.1 1 1 1 2 2 2 0 AAA-like domain AAA_2 PF07724.9 KOO53391.1 - 0.049 13.5 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) SRP54 PF00448.17 KOO53391.1 - 0.056 12.8 0.1 0.13 11.6 0.1 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_25 PF13481.1 KOO53391.1 - 0.077 12.3 1.1 0.58 9.5 0.8 2.4 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 KOO53391.1 - 0.11 12.7 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 ABC transporter RNA_helicase PF00910.17 KOO53391.1 - 0.17 12.0 0.0 0.31 11.2 0.0 1.4 1 0 0 1 1 1 0 RNA helicase Ank_2 PF12796.2 KOO53392.1 - 9.5e-23 80.3 3.0 1.6e-10 41.1 0.1 2.5 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO53392.1 - 1.5e-22 79.0 4.7 5.6e-11 42.3 0.1 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.25 KOO53392.1 - 1.4e-18 65.6 7.2 3.7e-05 23.3 0.2 4.6 3 1 1 4 4 4 4 Ankyrin repeat Ank_4 PF13637.1 KOO53392.1 - 2.9e-18 65.8 10.1 4.1e-06 27.1 0.3 4.0 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO53392.1 - 1.2e-13 49.8 2.1 0.023 14.8 0.0 4.6 4 0 0 4 4 4 4 Ankyrin repeat ApoO PF09769.4 KOO53393.1 - 0.034 13.8 2.3 0.034 13.8 0.7 1.6 1 1 1 2 2 2 0 Apolipoprotein O Lipoprotein_6 PF01441.14 KOO53393.1 - 0.097 12.5 2.7 0.11 12.3 1.5 1.3 1 1 0 1 1 1 0 Lipoprotein Cellulase PF00150.13 KOO53394.1 - 2.3e-30 105.7 0.0 3.3e-30 105.2 0.0 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Exo_endo_phos PF03372.18 KOO53394.1 - 7.7e-10 39.1 0.0 3.7e-09 36.8 0.0 2.2 2 1 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family Mito_carr PF00153.22 KOO53395.1 - 6.8e-17 60.9 6.1 4.3e-10 39.1 0.2 4.2 3 1 1 4 4 4 4 Mitochondrial carrier protein SHIPPO-rpt PF07004.7 KOO53396.1 - 3.3e-09 37.1 20.4 0.025 15.4 0.0 7.7 7 0 0 7 7 7 4 Sperm-tail PG-rich repeat ART PF01129.13 KOO53397.1 - 2.3e-12 46.4 0.0 2.9e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Ldh_1_C PF02866.13 KOO53398.1 - 1.3e-05 25.0 1.6 3.7e-05 23.5 0.0 2.4 3 0 0 3 3 3 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.18 KOO53399.1 - 2.7e-40 137.4 0.0 6.3e-40 136.2 0.0 1.6 1 1 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 KOO53399.1 - 5.4e-40 136.9 0.0 7.9e-40 136.4 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain RPAP3_C PF13877.1 KOO53400.1 - 2.1e-19 69.2 0.0 3.9e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 TPR_11 PF13414.1 KOO53400.1 - 8.4e-18 63.7 25.6 1.6e-13 50.0 3.1 2.7 1 1 2 3 3 3 3 TPR repeat TPR_1 PF00515.23 KOO53400.1 - 4.7e-11 41.7 7.1 0.00042 19.8 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO53400.1 - 5.6e-07 29.0 18.6 0.0036 17.0 0.4 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 KOO53400.1 - 1e-05 25.2 2.6 0.086 12.7 0.1 2.6 1 1 1 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.1 KOO53400.1 - 1e-05 25.2 4.3 0.38 11.0 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.1 KOO53400.1 - 0.00031 20.9 18.7 0.0013 18.9 5.0 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO53400.1 - 0.00058 20.4 25.6 0.0012 19.4 8.1 5.3 4 2 4 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.1 KOO53400.1 - 0.0014 18.4 13.7 0.0023 17.7 6.5 3.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO53400.1 - 0.0029 18.0 4.5 0.0029 18.0 3.1 5.7 4 1 2 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.1 KOO53400.1 - 4 7.4 7.3 1.6 8.6 0.0 3.3 3 1 1 4 4 4 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.1 KOO53400.1 - 4.1 7.6 7.8 1.5 9.0 1.4 2.6 1 1 1 2 2 2 0 Alkyl sulfatase dimerisation TPR_12 PF13424.1 KOO53400.1 - 6.3 6.8 17.1 10 6.1 5.0 2.7 1 1 1 2 2 2 0 Tetratricopeptide repeat PspC PF04024.7 KOO53401.1 - 0.051 13.0 0.2 0.15 11.5 0.1 1.7 1 0 0 1 1 1 0 PspC domain Nuc_sug_transp PF04142.10 KOO53402.1 - 4.7e-50 169.9 15.3 7.1e-50 169.3 10.6 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.6 KOO53402.1 - 2.3e-09 36.5 13.4 2.8e-09 36.3 9.3 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.15 KOO53402.1 - 3.9e-09 36.6 27.5 2.4e-06 27.5 4.0 2.8 2 1 0 2 2 2 2 EamA-like transporter family TPT PF03151.11 KOO53402.1 - 1.1e-06 28.3 23.7 1.9e-05 24.3 4.0 2.5 2 1 0 2 2 2 2 Triose-phosphate Transporter family EmrE PF13536.1 KOO53402.1 - 2.7e-05 24.3 3.8 2.7e-05 24.3 2.6 3.3 2 2 1 3 3 3 2 Multidrug resistance efflux transporter KfrA_N PF11740.3 KOO53402.1 - 0.11 12.9 0.0 0.25 11.7 0.0 1.5 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term Striatin PF08232.7 KOO53403.1 - 0.00085 19.6 2.0 0.0009 19.5 1.4 1.1 1 0 0 1 1 1 1 Striatin family GAS PF13851.1 KOO53403.1 - 0.008 15.3 1.4 0.0091 15.2 1.0 1.0 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Zwint PF15556.1 KOO53403.1 - 0.013 14.7 0.7 0.013 14.7 0.5 1.1 1 0 0 1 1 1 0 ZW10 interactor Filament PF00038.16 KOO53403.1 - 0.014 14.8 1.9 0.015 14.8 1.3 1.1 1 0 0 1 1 1 0 Intermediate filament protein TMF_DNA_bd PF12329.3 KOO53403.1 - 0.055 13.2 2.1 0.079 12.7 1.4 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding IncA PF04156.9 KOO53403.1 - 0.066 12.8 2.2 0.075 12.6 1.5 1.1 1 0 0 1 1 1 0 IncA protein DUF3450 PF11932.3 KOO53403.1 - 0.082 12.1 2.2 0.089 12.0 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DivIVA PF05103.8 KOO53403.1 - 0.089 12.8 3.5 0.091 12.8 2.4 1.1 1 0 0 1 1 1 0 DivIVA protein COG2 PF06148.6 KOO53403.1 - 0.096 12.5 2.3 0.11 12.3 1.6 1.1 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Med9 PF07544.8 KOO53403.1 - 0.23 11.2 2.4 0.29 10.8 1.5 1.3 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 SlyX PF04102.7 KOO53403.1 - 0.25 11.7 4.0 0.32 11.3 2.8 1.5 1 1 0 1 1 1 0 SlyX DivIC PF04977.10 KOO53403.1 - 0.49 9.9 4.0 0.71 9.4 2.8 1.3 1 0 0 1 1 1 0 Septum formation initiator DUF4404 PF14357.1 KOO53403.1 - 0.76 10.2 4.4 1.2 9.6 3.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4404) Ribosomal_L29 PF00831.18 KOO53403.1 - 1.7 8.3 4.7 5.2 6.8 0.5 2.8 1 1 2 3 3 3 0 Ribosomal L29 protein NYN PF01936.13 KOO53406.1 - 6e-19 68.7 0.0 1e-18 68.0 0.0 1.3 1 0 0 1 1 1 1 NYN domain UQ_con PF00179.21 KOO53407.1 - 7.5e-54 180.9 0.0 8.6e-31 106.2 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KOO53407.1 - 1.8e-09 37.4 0.1 0.00031 20.4 0.0 3.2 3 0 0 3 3 3 2 Prokaryotic E2 family B RWD PF05773.17 KOO53407.1 - 2.1e-07 30.7 0.0 0.0069 16.2 0.0 2.4 2 0 0 2 2 2 2 RWD domain UEV PF05743.8 KOO53407.1 - 1.5e-05 24.6 0.1 0.00063 19.4 0.0 2.4 2 0 0 2 2 2 1 UEV domain Pkinase PF00069.20 KOO53408.1 - 1.7e-50 171.6 0.0 2.6e-50 171.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.24 KOO53408.1 - 1e-25 89.3 1.1 2.3e-12 46.5 0.0 2.9 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.12 KOO53408.1 - 1.2e-20 73.6 0.0 2.6e-20 72.6 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase RGS PF00615.14 KOO53408.1 - 4.7e-06 26.6 0.0 5e-05 23.3 0.0 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain Kinase-like PF14531.1 KOO53408.1 - 0.02 13.8 0.0 0.039 12.9 0.0 1.5 1 0 0 1 1 1 0 Kinase-like RVT_2 PF07727.9 KOO53409.1 - 9e-05 21.5 0.0 9.8e-05 21.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pkinase PF00069.20 KOO53410.1 - 0.0057 15.8 0.1 0.0066 15.6 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO53410.1 - 0.1 11.6 0.1 0.11 11.4 0.0 1.0 1 0 0 1 1 1 0 Protein tyrosine kinase Exostosin PF03016.10 KOO53411.1 - 4.5e-44 150.6 0.0 8e-44 149.8 0.0 1.4 1 0 0 1 1 1 1 Exostosin family Beta_elim_lyase PF01212.16 KOO53412.1 - 3.9e-39 134.5 0.0 5.1e-39 134.1 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 KOO53412.1 - 0.13 11.2 0.1 0.4 9.6 0.1 1.7 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family LRR_4 PF12799.2 KOO53414.1 - 1.4e-17 62.8 7.3 6.2e-08 32.0 0.2 4.5 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 KOO53414.1 - 2.3e-14 52.8 7.6 1.4e-05 24.7 0.7 3.8 3 0 0 3 3 3 3 Leucine rich repeat Zeta_toxin PF06414.7 KOO53414.1 - 5e-10 38.8 0.0 0.00057 19.0 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin LRR_1 PF00560.28 KOO53414.1 - 6.3e-10 37.7 9.9 0.39 10.9 0.1 7.3 7 0 0 7 7 7 4 Leucine Rich Repeat LRR_6 PF13516.1 KOO53414.1 - 1e-06 28.1 5.4 1.6 9.0 0.2 5.8 5 0 0 5 5 5 2 Leucine Rich repeat AAA_33 PF13671.1 KOO53414.1 - 0.0026 17.6 0.0 0.011 15.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 KOO53414.1 - 0.0067 17.2 0.3 0.077 13.8 0.0 2.9 2 1 0 2 2 2 1 AAA domain Bap31 PF05529.7 KOO53414.1 - 0.0073 15.7 3.3 0.0073 15.7 2.3 2.5 2 0 0 2 2 2 1 B-cell receptor-associated protein 31-like Snapin_Pallidin PF14712.1 KOO53414.1 - 0.01 16.1 2.5 0.01 16.1 1.8 3.0 4 0 0 4 4 1 0 Snapin/Pallidin AAA PF00004.24 KOO53414.1 - 0.09 12.9 0.0 0.65 10.2 0.0 2.5 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) YABBY PF04690.8 KOO53414.1 - 0.19 11.9 3.0 0.82 9.8 2.1 2.1 1 1 0 1 1 1 0 YABBY protein Leucyl-specific PF14795.1 KOO53414.1 - 0.37 10.6 4.7 0.35 10.7 0.1 2.9 2 0 0 2 2 2 0 Leucine-tRNA synthetase-specific domain LRR_7 PF13504.1 KOO53414.1 - 0.59 10.5 20.2 5.8 7.5 0.1 7.2 8 0 0 8 8 7 0 Leucine rich repeat TMPIT PF07851.8 KOO53414.1 - 0.79 8.7 2.2 2 7.4 1.5 1.7 1 0 0 1 1 1 0 TMPIT-like protein DUF641 PF04859.7 KOO53414.1 - 1.2 8.9 10.6 0.44 10.3 3.3 3.0 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) V_ATPase_I PF01496.14 KOO53414.1 - 3.6 5.3 3.5 6 4.5 2.4 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SET PF00856.23 KOO53415.1 - 3.2e-08 34.0 0.3 0.00028 21.2 0.0 2.5 2 1 1 3 3 3 2 SET domain SAF PF08666.7 KOO53415.1 - 0.055 13.8 0.2 2.6 8.4 0.1 2.6 2 0 0 2 2 2 0 SAF domain AP2 PF00847.15 KOO53416.1 - 4.3e-08 33.1 7.3 0.0023 18.0 0.1 3.4 3 0 0 3 3 3 3 AP2 domain DUF4145 PF13643.1 KOO53417.1 - 0.04 13.7 0.0 0.051 13.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4145) zf-CXXC PF02008.15 KOO53418.1 - 1.2e-06 28.1 2.8 2.4e-06 27.2 1.9 1.4 1 0 0 1 1 1 1 CXXC zinc finger domain Methyltransf_21 PF05050.7 KOO53419.1 - 3e-12 46.8 0.0 5.8e-12 45.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase FkbM domain NPCBM_assoc PF10633.4 KOO53419.1 - 0.0027 17.6 0.6 0.0089 16.0 0.1 2.0 2 0 0 2 2 2 1 NPCBM-associated, NEW3 domain of alpha-galactosidase Methyltransf_18 PF12847.2 KOO53419.1 - 0.033 14.7 0.0 0.11 13.0 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.1 KOO53419.1 - 0.11 12.2 0.0 0.37 10.5 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain SDA1 PF05285.7 KOO53420.1 - 1.1e-44 153.1 25.1 2.9e-25 89.2 0.1 3.0 2 1 1 3 3 3 2 SDA1 NUC130_3NT PF08158.7 KOO53420.1 - 3.5e-19 68.8 0.8 4.5e-18 65.2 0.1 2.7 3 0 0 3 3 3 1 NUC130/3NT domain Dynein_heavy PF03028.10 KOO53421.1 - 2.1e-31 108.7 0.0 2.9e-31 108.2 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain and region D6 of dynein motor AAA_5 PF07728.9 KOO53421.1 - 2.7e-21 75.7 0.0 5.1e-21 74.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ABC_tran PF00005.22 KOO53421.1 - 0.0034 17.6 0.0 0.007 16.6 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_17 PF13207.1 KOO53421.1 - 0.0051 17.6 0.0 0.032 15.0 0.0 2.2 2 1 1 3 3 3 1 AAA domain RNA_helicase PF00910.17 KOO53421.1 - 0.0056 16.8 0.0 0.016 15.3 0.0 1.8 1 0 0 1 1 1 1 RNA helicase DUF258 PF03193.11 KOO53421.1 - 0.01 15.0 0.0 0.049 12.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF258 UPF0079 PF02367.12 KOO53421.1 - 0.04 13.5 0.0 0.083 12.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_28 PF13521.1 KOO53421.1 - 0.066 13.1 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 KOO53421.1 - 0.086 13.1 0.0 0.25 11.6 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.1 KOO53421.1 - 0.12 12.5 0.0 0.3 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 KOO53421.1 - 0.12 11.9 0.0 0.29 10.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.1 KOO53421.1 - 0.16 11.8 0.0 0.58 10.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain Fer4_NifH PF00142.13 KOO53421.1 - 0.18 10.9 0.0 0.3 10.2 0.0 1.3 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Rad17 PF03215.10 KOO53421.1 - 0.18 10.4 0.0 0.28 9.8 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein DHC_N2 PF08393.8 KOO53422.1 - 1.6e-109 366.1 0.0 7.2e-109 363.9 0.0 2.1 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 KOO53422.1 - 2.9e-76 256.0 0.0 4.9e-76 255.2 0.0 1.3 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region D1 DHC_N1 PF08385.7 KOO53422.1 - 3.5e-35 121.4 0.1 2.5e-34 118.6 0.0 2.1 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 1 AAA PF00004.24 KOO53422.1 - 0.0084 16.3 0.0 0.029 14.5 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 KOO53422.1 - 0.013 16.3 0.0 3 8.6 0.0 3.6 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.1 KOO53422.1 - 0.014 15.4 0.4 0.48 10.5 0.0 3.5 3 0 0 3 3 3 0 AAA domain DUF2505 PF10698.4 KOO53423.1 - 2.7e-08 33.4 0.0 2.9e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2505) His_Phos_1 PF00300.17 KOO53424.1 - 2.7e-07 30.8 0.0 5e-07 29.9 0.0 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Kinesin PF00225.18 KOO53425.1 - 2.1e-71 240.3 0.0 3e-71 239.8 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain LKAAEAR PF15478.1 KOO53425.1 - 0.11 12.7 0.1 0.33 11.1 0.0 1.8 2 0 0 2 2 2 0 Family of unknown function with LKAAEAR motif Complex1_LYR PF05347.10 KOO53426.1 - 0.0065 16.2 0.1 0.045 13.5 0.1 2.1 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 KOO53426.1 - 0.0091 16.1 0.3 0.05 13.8 0.2 2.1 1 1 0 1 1 1 1 Complex1_LYR-like C2 PF00168.25 KOO53427.1 - 5e-10 39.0 0.0 8e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 C2 domain Tyr_Deacylase PF02580.11 KOO53429.1 - 0.0069 16.3 0.1 0.05 13.5 0.0 2.2 2 0 0 2 2 2 1 D-Tyr-tRNA(Tyr) deacylase AICARFT_IMPCHas PF01808.13 KOO53429.1 - 0.023 13.7 0.0 0.05 12.7 0.0 1.5 1 0 0 1 1 1 0 AICARFT/IMPCHase bienzyme Jiraiya PF15038.1 KOO53430.1 - 0.089 12.2 9.2 0.14 11.5 6.4 1.3 1 0 0 1 1 1 0 Jiraiya Strabismus PF06638.6 KOO53430.1 - 0.094 11.0 0.9 0.12 10.6 0.6 1.1 1 0 0 1 1 1 0 Strabismus protein Pex24p PF06398.6 KOO53430.1 - 0.32 9.7 3.8 0.08 11.7 0.3 1.7 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin DUF2614 PF11023.3 KOO53430.1 - 1 9.1 6.0 0.29 10.9 1.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2614) UxaC PF02614.9 KOO53431.1 - 6.8e-47 160.1 0.0 1e-46 159.5 0.0 1.2 1 0 0 1 1 1 1 Glucuronate isomerase Mannitol_dh_C PF08125.8 KOO53431.1 - 0.0087 15.2 0.1 0.17 11.0 0.1 2.6 1 1 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain rve PF00665.21 KOO53432.1 - 1.2e-14 54.4 0.0 2.3e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain PABP PF00658.13 KOO53432.1 - 0.24 11.0 0.0 0.48 10.1 0.0 1.5 1 0 0 1 1 1 0 Poly-adenylate binding protein, unique domain FSH1 PF03959.8 KOO53435.1 - 8.4e-37 126.6 0.0 9.8e-37 126.4 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 KOO53435.1 - 5.4e-06 26.2 0.0 8.1e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 KOO53435.1 - 0.00053 19.4 0.0 0.00078 18.9 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.2 KOO53435.1 - 0.0014 18.5 2.1 0.025 14.4 1.1 2.4 1 1 1 2 2 2 1 Alpha/beta hydrolase family DLH PF01738.13 KOO53435.1 - 0.018 14.3 0.1 0.053 12.7 0.0 1.8 1 1 0 1 1 1 0 Dienelactone hydrolase family Peptidase_S9 PF00326.16 KOO53435.1 - 0.052 12.7 0.0 0.13 11.4 0.0 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family Thioesterase PF00975.15 KOO53435.1 - 0.11 12.6 0.2 0.24 11.5 0.1 1.6 1 1 0 1 1 1 0 Thioesterase domain DUF2874 PF11396.3 KOO53436.1 - 0.093 12.7 0.4 14 5.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2874) cobW PF02492.14 KOO53437.1 - 5.8e-50 169.1 0.5 9.3e-50 168.5 0.3 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 KOO53437.1 - 3.8e-19 68.2 0.4 9.9e-19 66.8 0.1 1.9 2 0 0 2 2 1 1 Cobalamin synthesis protein cobW C-terminal domain EF-hand_7 PF13499.1 KOO53437.1 - 6.3e-07 29.4 4.3 0.00047 20.2 3.0 4.0 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO53437.1 - 1.8e-06 27.3 6.7 0.0038 16.9 0.1 4.9 4 0 0 4 4 4 1 EF-hand domain EF-hand_1 PF00036.27 KOO53437.1 - 4.5e-06 25.5 4.6 0.046 13.0 0.2 4.0 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.1 KOO53437.1 - 0.00084 18.9 4.7 0.72 9.5 0.0 3.9 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO53437.1 - 0.0013 17.9 4.8 0.015 14.6 0.3 3.4 3 0 0 3 3 3 1 EF hand AAA_29 PF13555.1 KOO53437.1 - 0.0085 15.6 0.0 0.023 14.2 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.22 KOO53437.1 - 0.0085 16.3 0.0 0.029 14.6 0.0 1.9 1 1 0 1 1 1 1 ABC transporter AAA_19 PF13245.1 KOO53437.1 - 0.012 15.3 0.1 0.045 13.5 0.1 1.9 1 0 0 1 1 1 0 Part of AAA domain AAA_16 PF13191.1 KOO53437.1 - 0.024 14.6 0.6 0.081 12.9 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain Arch_ATPase PF01637.13 KOO53437.1 - 0.026 14.2 0.0 0.059 13.0 0.0 1.6 1 0 0 1 1 1 0 Archaeal ATPase AAA_22 PF13401.1 KOO53437.1 - 0.034 14.2 0.1 0.12 12.5 0.0 1.9 2 0 0 2 2 1 0 AAA domain MMR_HSR1 PF01926.18 KOO53437.1 - 0.038 13.9 0.7 0.1 12.5 0.5 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase T2SE PF00437.15 KOO53437.1 - 0.053 12.4 0.1 0.11 11.4 0.1 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_28 PF13521.1 KOO53437.1 - 0.066 13.1 1.3 0.41 10.5 0.1 2.8 3 1 0 3 3 3 0 AAA domain AAA_23 PF13476.1 KOO53437.1 - 0.067 13.5 1.3 0.15 12.3 0.9 1.7 1 1 0 1 1 1 0 AAA domain UPF0079 PF02367.12 KOO53437.1 - 0.071 12.7 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Zeta_toxin PF06414.7 KOO53437.1 - 0.076 12.0 0.0 0.35 9.9 0.0 2.0 3 0 0 3 3 3 0 Zeta toxin AAA_14 PF13173.1 KOO53437.1 - 0.089 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.22 KOO53437.1 - 0.099 12.0 0.3 9.9 5.5 0.1 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_18 PF13238.1 KOO53437.1 - 0.14 12.4 1.1 0.45 10.8 0.7 2.1 1 1 0 1 1 1 0 AAA domain Sulfotransfer_1 PF00685.22 KOO53439.1 - 0.00013 21.2 0.0 0.00022 20.5 0.0 1.3 1 1 0 1 1 1 1 Sulfotransferase domain Spc7 PF08317.6 KOO53440.1 - 0.046 12.3 9.0 0.059 12.0 6.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein alpha-hel2 PF14456.1 KOO53440.1 - 0.23 10.1 15.0 1.9 7.1 10.4 2.0 1 1 0 1 1 1 0 Alpha-helical domain 2 XhlA PF10779.4 KOO53440.1 - 0.36 10.7 9.5 14 5.6 6.6 2.6 1 1 0 1 1 1 0 Haemolysin XhlA DUF4201 PF13870.1 KOO53440.1 - 0.43 9.9 11.9 0.068 12.6 1.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Macoilin PF09726.4 KOO53440.1 - 1.4 7.1 14.3 2.6 6.2 9.9 1.4 1 1 0 1 1 1 0 Transmembrane protein SlyX PF04102.7 KOO53440.1 - 1.6 9.1 13.1 3.9 7.9 2.0 2.7 2 1 1 3 3 3 0 SlyX Atg14 PF10186.4 KOO53440.1 - 3.2 6.6 13.6 4.7 6.0 9.5 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 MerR-DNA-bind PF09278.6 KOO53440.1 - 5.5 7.4 25.5 0.85 10.0 4.5 3.3 2 2 2 4 4 4 0 MerR, DNA binding DUF972 PF06156.8 KOO53440.1 - 7.6 6.9 8.1 0.76 10.1 0.5 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF972) Totivirus_coat PF05518.6 KOO53441.1 - 4.9 4.8 6.2 6 4.5 4.3 1.1 1 0 0 1 1 1 0 Totivirus coat protein Ank_2 PF12796.2 KOO53442.1 - 3.6e-45 152.2 12.2 2.3e-14 53.4 0.6 4.4 1 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.25 KOO53442.1 - 8.1e-30 101.1 22.7 0.0003 20.4 0.1 8.4 8 0 0 8 8 8 7 Ankyrin repeat Ank_3 PF13606.1 KOO53442.1 - 2.8e-25 85.8 8.2 0.0034 17.4 0.0 8.0 8 0 0 8 8 8 7 Ankyrin repeat Ank_4 PF13637.1 KOO53442.1 - 3.8e-25 87.7 4.9 9.1e-07 29.2 0.0 5.3 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO53442.1 - 1.1e-24 85.8 18.0 2.9e-07 30.5 0.0 7.3 3 3 5 8 8 8 6 Ankyrin repeats (many copies) Reo_sigmaC PF04582.7 KOO53443.1 - 0.22 10.6 3.6 0.26 10.3 2.1 1.4 1 1 0 1 1 1 0 Reovirus sigma C capsid protein Vfa1 PF08432.5 KOO53443.1 - 4.2 7.3 16.5 7.3 6.5 11.4 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Herpes_env PF01673.13 KOO53443.1 - 4.4 5.7 14.5 6.4 5.2 10.1 1.2 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein Tubulin PF00091.20 KOO53444.1 - 4.5e-55 186.7 0.0 6.1e-55 186.3 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 KOO53444.1 - 1.8e-09 37.7 0.1 2.8e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.1 KOO53444.1 - 0.0036 16.8 0.0 0.0078 15.6 0.0 1.6 2 0 0 2 2 2 1 Tubulin domain EF-hand_1 PF00036.27 KOO53445.1 - 8.9e-40 130.9 13.0 6.8e-06 25.0 0.0 7.5 6 1 1 7 7 7 6 EF hand EF-hand_6 PF13405.1 KOO53445.1 - 1.1e-36 121.4 8.0 1.3e-05 24.6 0.0 7.7 5 1 2 7 7 7 7 EF-hand domain EF-hand_7 PF13499.1 KOO53445.1 - 2.2e-32 110.9 7.4 2.2e-11 43.7 0.2 4.5 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO53445.1 - 1.2e-29 101.6 14.3 4.9e-07 29.2 0.2 6.5 4 2 2 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.1 KOO53445.1 - 5.7e-23 79.1 11.6 0.0022 17.2 0.0 7.3 6 1 1 7 7 7 6 EF hand EF-hand_4 PF12763.2 KOO53445.1 - 3.2e-08 33.2 4.3 0.51 10.1 0.0 5.7 3 3 3 6 6 6 3 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.1 KOO53445.1 - 0.0027 17.3 3.5 2.2 8.0 0.1 4.9 4 2 1 5 5 5 1 EF hand Toprim_2 PF13155.1 KOO53445.1 - 0.026 14.8 0.7 10 6.4 0.0 3.9 2 2 1 3 3 3 0 Toprim-like SPX PF03105.14 KOO53445.1 - 0.038 13.7 2.3 0.065 13.0 1.6 1.4 1 0 0 1 1 1 0 SPX domain Toprim PF01751.17 KOO53445.1 - 0.039 13.9 0.0 5.2 7.0 0.0 3.4 3 1 0 3 3 3 0 Toprim domain EF-hand_9 PF14658.1 KOO53445.1 - 0.19 11.6 0.5 5.1 7.0 0.0 3.5 6 0 0 6 6 5 0 EF-hand domain SPARC_Ca_bdg PF10591.4 KOO53445.1 - 1.1 9.3 16.7 1.6 8.8 0.0 6.0 4 3 0 5 5 4 0 Secreted protein acidic and rich in cysteine Ca binding region DUF1963 PF09234.5 KOO53446.1 - 0.38 10.9 2.7 0.5 10.5 1.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1963) Solute_trans_a PF03619.11 KOO53447.1 - 8e-08 31.9 4.7 8.4e-07 28.5 3.2 2.2 1 1 0 1 1 1 1 Organic solute transporter Ostalpha DUF3491 PF11996.3 KOO53448.1 - 0.057 10.9 0.0 0.078 10.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3491) Aminotran_5 PF00266.14 KOO53449.1 - 4.4e-09 35.5 0.0 6.5e-09 35.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Reo_sigmaC PF04582.7 KOO53451.1 - 0.31 10.1 7.9 0.098 11.8 2.2 2.1 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Tweety PF04906.8 KOO53451.1 - 0.46 8.8 6.1 0.12 10.8 0.3 2.1 2 0 0 2 2 2 0 Tweety GldM_N PF12081.3 KOO53451.1 - 3.6 7.0 12.8 0.76 9.2 0.5 3.2 2 2 1 3 3 3 0 GldM N-terminal domain OAD_gamma PF04277.8 KOO53452.1 - 0.13 12.6 1.2 2.1 8.8 0.1 2.8 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain PIH1 PF08190.7 KOO53455.1 - 1e-24 87.5 0.0 2.5e-13 50.2 0.0 3.0 3 0 0 3 3 3 2 pre-RNA processing PIH1/Nop17 Histone PF00125.19 KOO53458.1 - 9.2e-34 115.4 0.3 1.4e-33 114.8 0.2 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 KOO53458.1 - 0.00019 21.5 0.0 0.00029 20.9 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 KOO53458.1 - 0.0031 17.5 0.0 0.0062 16.5 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T PF15511.1 KOO53458.1 - 0.02 14.1 0.4 0.03 13.5 0.3 1.5 1 1 0 1 1 1 0 Centromere kinetochore component CENP-T TPR_11 PF13414.1 KOO53459.1 - 8.5e-07 28.5 0.2 0.0069 16.0 0.0 2.7 2 1 1 3 3 3 2 TPR repeat TPR_16 PF13432.1 KOO53459.1 - 0.00061 20.3 0.3 0.0027 18.3 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO53459.1 - 0.07 13.4 0.0 0.23 11.8 0.0 1.8 1 1 1 2 2 2 0 Tetratricopeptide repeat 2OG-FeII_Oxy_4 PF13661.1 KOO53459.1 - 0.11 12.2 0.3 0.36 10.5 0.1 1.9 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily BRE1 PF08647.6 KOO53460.1 - 0.0022 17.9 0.7 0.0022 17.9 0.5 2.4 2 1 0 2 2 2 1 BRE1 E3 ubiquitin ligase Exostosin PF03016.10 KOO53461.1 - 2.6e-05 23.4 0.0 3e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Exostosin family UxuA PF03786.8 KOO53463.1 - 2e-128 427.8 0.0 2.4e-128 427.6 0.0 1.0 1 0 0 1 1 1 1 D-mannonate dehydratase (UxuA) AP_endonuc_2 PF01261.19 KOO53463.1 - 1.8e-06 27.4 0.0 8.1e-06 25.2 0.0 2.1 2 1 0 2 2 2 1 Xylose isomerase-like TIM barrel ComJ PF11033.3 KOO53463.1 - 0.035 13.7 0.1 0.21 11.2 0.0 2.0 2 0 0 2 2 2 0 Competence protein J (ComJ) NanE PF04131.9 KOO53463.1 - 0.11 11.4 0.0 0.21 10.5 0.0 1.4 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase DUF2465 PF10239.4 KOO53464.1 - 3.3e-28 98.8 0.0 4.6e-28 98.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2465) SLAIN PF15301.1 KOO53465.1 - 0.042 13.0 9.0 0.043 12.9 6.2 1.1 1 0 0 1 1 1 0 SLAIN motif-containing family LRR_6 PF13516.1 KOO53466.1 - 5.7e-14 50.5 7.7 0.048 13.7 0.1 7.4 7 0 0 7 7 7 3 Leucine Rich repeat Skp1 PF01466.14 KOO53466.1 - 1.3e-06 28.3 0.0 3.5e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 Skp1 family, dimerisation domain LRR_8 PF13855.1 KOO53466.1 - 0.011 15.4 1.8 32 4.3 0.0 4.6 4 1 1 5 5 5 0 Leucine rich repeat LRR_1 PF00560.28 KOO53466.1 - 0.012 15.5 2.2 30 5.1 0.0 5.4 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_7 PF13504.1 KOO53466.1 - 0.025 14.6 2.0 52 4.7 0.0 5.3 6 0 0 6 6 6 0 Leucine rich repeat DUF2501 PF10696.4 KOO53466.1 - 0.086 12.8 0.4 6.8 6.7 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2501) LRR_4 PF12799.2 KOO53466.1 - 0.39 10.4 5.6 5.9 6.6 0.0 3.9 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) WD40 PF00400.27 KOO53467.1 - 1.5e-10 40.5 3.3 0.092 12.6 0.0 6.4 7 0 0 7 7 7 4 WD domain, G-beta repeat PQQ_2 PF13360.1 KOO53467.1 - 8.1e-05 22.1 0.4 0.29 10.5 0.0 2.8 1 1 2 3 3 3 2 PQQ-like domain Cytochrom_D1 PF02239.11 KOO53467.1 - 0.11 10.7 0.0 10 4.3 0.0 2.2 2 0 0 2 2 2 0 Cytochrome D1 heme domain Tudor-knot PF11717.3 KOO53468.1 - 3e-08 33.2 0.0 8.1e-08 31.8 0.0 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain AP2 PF00847.15 KOO53468.1 - 2.7e-07 30.6 25.1 0.00047 20.2 0.0 6.0 6 2 0 6 6 6 3 AP2 domain DUF2960 PF11173.3 KOO53468.1 - 0.066 13.5 0.2 18 5.7 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2960) AbrB-like PF14250.1 KOO53468.1 - 0.07 13.0 0.2 13 5.8 0.0 3.0 3 0 0 3 3 3 0 AbrB-like transcriptional regulator IF3_N PF05198.11 KOO53468.1 - 0.11 12.3 2.0 36 4.3 0.0 3.5 3 0 0 3 3 3 0 Translation initiation factor IF-3, N-terminal domain Nif11 PF07862.6 KOO53468.1 - 9.9 6.2 8.2 0.45 10.5 1.0 2.3 3 0 0 3 3 3 0 Nitrogen fixation protein of unknown function DUF2493 PF10686.4 KOO53468.1 - 10 5.7 11.5 15 5.2 0.2 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2493) MSP1a PF11670.3 KOO53471.1 - 0.028 14.2 0.4 0.038 13.8 0.3 1.1 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) Rad60-SLD PF11976.3 KOO53472.1 - 3e-12 46.0 0.0 4.4e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 KOO53472.1 - 0.14 11.5 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin family Yae1_N PF09811.4 KOO53472.1 - 0.51 9.9 3.4 1.8 8.1 2.3 2.0 1 0 0 1 1 1 0 Essential protein Yae1, N terminal SAP PF02037.22 KOO53473.1 - 5.3e-10 38.5 1.3 1.8e-09 36.8 0.9 2.0 1 0 0 1 1 1 1 SAP domain Pkinase PF00069.20 KOO53474.1 - 4e-34 117.9 0.0 5.8e-34 117.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO53474.1 - 1.5e-32 112.7 0.0 1.9e-32 112.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase TIR_2 PF13676.1 KOO53474.1 - 1.9e-05 24.7 0.0 7.5e-05 22.8 0.0 2.0 2 0 0 2 2 2 1 TIR domain APH PF01636.18 KOO53474.1 - 0.00064 19.5 0.4 0.028 14.1 0.0 2.2 1 1 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.1 KOO53474.1 - 0.011 14.6 0.0 0.019 13.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Cellulase-like PF12876.2 KOO53474.1 - 0.014 15.8 0.0 0.042 14.2 0.0 1.8 1 0 0 1 1 1 0 Sugar-binding cellulase-like DUF1822 PF08852.6 KOO53474.1 - 0.092 11.5 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1822) TIR_2 PF13676.1 KOO53475.1 - 7.4e-06 26.0 0.0 1.6e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 TIR domain DEAD PF00270.24 KOO53476.1 - 2.8e-08 33.4 0.0 5.8e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C2HC_2 PF13913.1 KOO53477.1 - 9.8e-12 44.2 16.6 1.1e-11 44.0 1.8 3.8 4 0 0 4 4 4 3 zinc-finger of a C2HC-type zf-C2H2 PF00096.21 KOO53477.1 - 0.1 12.9 3.2 1 9.8 0.6 3.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type RVT_1 PF00078.22 KOO53479.1 - 0.0081 15.5 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Arm PF00514.18 KOO53480.1 - 2.9e-05 23.7 0.2 2.9e-05 23.7 0.2 2.6 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat Choline_transpo PF04515.7 KOO53481.1 - 1.2e-51 175.4 22.9 9.3e-51 172.5 6.1 3.0 3 0 0 3 3 3 2 Plasma-membrane choline transporter Pkinase PF00069.20 KOO53483.1 - 5.9e-53 179.6 0.0 8.8e-53 179.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO53483.1 - 1.5e-31 109.4 0.0 2.1e-31 108.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 KOO53483.1 - 0.00055 19.7 1.4 0.33 10.6 0.0 3.2 2 2 1 3 3 3 2 Phosphotransferase enzyme family RCC1 PF00415.13 KOO53483.1 - 0.0042 17.2 0.6 0.028 14.6 0.0 2.5 2 0 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat Kinase-like PF14531.1 KOO53483.1 - 0.012 14.6 0.0 0.02 13.8 0.0 1.3 1 0 0 1 1 1 0 Kinase-like RCC1_2 PF13540.1 KOO53483.1 - 0.048 13.2 2.8 3.6 7.3 0.1 2.8 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat RepL PF05732.6 KOO53483.1 - 0.12 11.5 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Firmicute plasmid replication protein (RepL) HRDC PF00570.18 KOO53484.1 - 2.8e-05 23.7 0.0 4.7e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 HRDC domain SWIM PF04434.12 KOO53484.1 - 0.036 13.5 0.3 0.073 12.5 0.2 1.5 1 0 0 1 1 1 0 SWIM zinc finger Tup_N PF08581.5 KOO53485.1 - 3.1 8.0 10.0 0.68 10.1 3.3 2.8 2 1 0 2 2 2 0 Tup N-terminal TBPIP PF07106.8 KOO53485.1 - 4.9 6.6 9.1 4.3 6.8 3.2 2.7 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) BBP1_C PF15272.1 KOO53485.1 - 7.9 5.9 9.1 2 7.9 0.3 2.7 1 1 1 2 2 2 0 Spindle pole body component BBP1, C-terminal UBA PF00627.26 KOO53486.1 - 4.1e-06 26.4 1.4 2.2e-05 24.1 0.0 2.7 3 0 0 3 3 3 1 UBA/TS-N domain CSD PF00313.17 KOO53486.1 - 0.00017 21.2 0.0 0.00027 20.6 0.0 1.3 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain MATH PF00917.21 KOO53486.1 - 0.00021 21.5 0.0 0.00045 20.4 0.0 1.5 1 0 0 1 1 1 1 MATH domain DNA_processg_A PF02481.10 KOO53487.1 - 1.3e-05 24.2 0.0 1.9e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 DNA recombination-mediator protein A RBB1NT PF08169.6 KOO53487.1 - 0.02 14.7 0.0 0.038 13.9 0.0 1.4 1 0 0 1 1 1 0 RBB1NT (NUC162) domain NAD_binding_1 PF00175.16 KOO53489.1 - 2.5e-25 89.1 0.3 8.4e-25 87.4 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_1 PF00667.15 KOO53489.1 - 9.4e-05 21.9 0.0 0.055 12.9 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain FAD_binding_6 PF00970.19 KOO53489.1 - 0.00031 20.8 0.0 0.00065 19.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain FAD_binding_9 PF08021.6 KOO53489.1 - 0.06 13.3 0.0 0.16 11.9 0.0 1.7 2 0 0 2 2 2 0 Siderophore-interacting FAD-binding domain NAD_binding_6 PF08030.7 KOO53489.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Ferric reductase NAD binding domain EF-hand_1 PF00036.27 KOO53490.1 - 1.8e-47 155.0 5.6 3.1e-06 26.0 0.0 8.5 8 0 0 8 8 8 8 EF hand EF-hand_6 PF13405.1 KOO53490.1 - 6.5e-43 140.7 7.6 0.00018 21.1 0.0 8.6 8 0 0 8 8 8 8 EF-hand domain EF-hand_7 PF13499.1 KOO53490.1 - 2.7e-35 120.3 0.7 1.5e-07 31.4 0.0 7.0 6 1 0 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.1 KOO53490.1 - 8.8e-29 97.5 12.2 8.5e-05 21.7 0.0 8.6 8 0 0 8 8 8 7 EF hand EF-hand_8 PF13833.1 KOO53490.1 - 4.6e-19 67.7 12.1 0.0015 18.1 0.1 8.2 7 1 1 8 8 8 4 EF-hand domain pair EF-hand_4 PF12763.2 KOO53490.1 - 3.2e-08 33.2 4.2 2.7 7.7 0.0 6.5 4 3 3 7 7 7 3 Cytoskeletal-regulatory complex EF hand Toprim_2 PF13155.1 KOO53490.1 - 1.5e-05 25.2 0.9 5.4 7.4 0.1 6.4 4 3 3 7 7 7 1 Toprim-like Cbl_N2 PF02761.9 KOO53490.1 - 0.0022 18.0 0.0 5.3 7.1 0.0 4.0 4 0 0 4 4 4 1 CBL proto-oncogene N-terminus, EF hand-like domain Hydantoinase_A PF01968.13 KOO53490.1 - 0.22 10.5 3.8 0.079 12.0 0.6 1.7 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase DUF2939 PF11159.3 KOO53491.1 - 0.0065 16.6 0.0 0.17 12.1 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2939) GFO_IDH_MocA PF01408.17 KOO53492.1 - 2.7e-06 27.8 0.0 5e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Endonuclease_1 PF04231.8 KOO53493.1 - 7.8e-38 130.4 0.0 1.3e-37 129.7 0.0 1.3 1 0 0 1 1 1 1 Endonuclease I Homeobox PF00046.24 KOO53494.1 - 2.1e-15 56.0 2.7 3.2e-15 55.4 1.9 1.3 1 0 0 1 1 1 1 Homeobox domain WD40 PF00400.27 KOO53496.1 - 1.4e-90 294.2 30.5 1.1e-12 47.3 0.3 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat PD40 PF07676.7 KOO53496.1 - 2.5e-18 65.2 7.4 0.34 10.6 0.0 7.4 7 0 0 7 7 7 7 WD40-like Beta Propeller Repeat DUF3312 PF11768.3 KOO53496.1 - 1e-05 24.0 0.0 1.7 6.7 0.0 4.0 1 1 3 4 4 4 3 Protein of unknown function (DUF3312) Nup160 PF11715.3 KOO53496.1 - 0.00049 18.3 14.9 0.0091 14.1 0.1 4.7 1 1 3 4 4 4 3 Nucleoporin Nup120/160 RED_C PF07807.6 KOO53496.1 - 0.0016 18.6 2.2 4.8 7.3 0.2 4.4 2 2 2 4 4 4 1 RED-like protein C-terminal region Osteoregulin PF07175.6 KOO53496.1 - 0.015 15.1 2.1 13 5.6 0.2 4.3 1 1 2 3 3 3 0 Osteoregulin S_layer_C PF05124.7 KOO53496.1 - 0.067 12.8 0.8 0.1 12.2 0.3 1.5 1 1 0 1 1 1 0 S-layer like family, C-terminal region dsrm PF00035.20 KOO53496.1 - 0.18 12.4 0.3 1.5e+02 3.0 0.0 4.2 5 0 0 5 5 5 0 Double-stranded RNA binding motif Dfp1_Him1_M PF08630.5 KOO53496.1 - 0.46 10.2 12.7 16 5.3 0.1 5.1 6 1 0 6 6 6 0 Dfp1/Him1, central region DUF1601 PF07671.6 KOO53497.1 - 1.3e-30 104.7 31.9 0.0029 17.1 0.2 10.3 2 1 8 10 10 10 9 Protein of unknown function (DUF1601) FAST_1 PF06743.10 KOO53497.1 - 2.7e-12 46.2 0.0 2 8.2 0.0 8.3 2 1 8 10 10 10 7 FAST kinase-like protein, subdomain 1 DUF445 PF04286.7 KOO53497.1 - 0.0015 18.1 0.0 0.34 10.4 0.0 3.3 1 1 0 1 1 1 1 Protein of unknown function (DUF445) DUF427 PF04248.7 KOO53497.1 - 0.022 14.4 29.2 23 4.7 0.1 8.2 8 0 0 8 8 8 0 Domain of unknown function (DUF427) CTP_transf_3 PF02348.14 KOO53498.1 - 1.9e-32 112.6 0.0 2.2e-32 112.4 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transf_3 PF12804.2 KOO53498.1 - 5.6e-07 29.7 0.0 7.6e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain HEAT_2 PF13646.1 KOO53499.1 - 0.00043 20.4 0.9 0.068 13.4 0.1 2.9 2 1 0 2 2 2 2 HEAT repeats RRM_1 PF00076.17 KOO53499.1 - 0.057 13.0 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO53499.1 - 0.097 12.6 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Cellulase PF00150.13 KOO53501.1 - 6.5e-34 117.4 0.0 7.6e-34 117.1 0.0 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Cellulase PF00150.13 KOO53502.1 - 1.3e-08 34.4 0.0 1.6e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) LOH1CR12 PF10158.4 KOO53503.1 - 0.054 13.2 2.3 0.14 11.9 1.6 1.7 1 0 0 1 1 1 0 Tumour suppressor protein PhageMin_Tail PF10145.4 KOO53503.1 - 2.3 7.8 17.5 0.025 14.2 6.1 1.9 2 0 0 2 2 2 0 Phage-related minor tail protein Phage_int_SAM_5 PF13102.1 KOO53503.1 - 7.8 6.5 10.9 1.8 8.5 2.4 2.4 2 0 0 2 2 2 0 Phage integrase SAM-like domain TFIIA PF03153.8 KOO53503.1 - 8.4 6.1 14.5 7.9 6.2 9.3 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit LRR_4 PF12799.2 KOO53504.1 - 9.1e-08 31.5 5.1 0.36 10.5 0.0 6.1 5 1 2 7 7 7 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 KOO53504.1 - 4.7e-06 25.9 13.9 5.8 7.3 0.0 8.3 9 0 0 9 9 9 1 Leucine Rich Repeat LRR_6 PF13516.1 KOO53504.1 - 0.00023 20.9 12.6 70 3.9 0.0 8.9 10 0 0 10 10 10 0 Leucine Rich repeat LRR_7 PF13504.1 KOO53504.1 - 0.0005 19.8 24.6 2 8.9 0.0 9.3 9 1 0 9 9 9 2 Leucine rich repeat LRR_2 PF07723.8 KOO53504.1 - 6.5 7.4 7.9 47 4.6 1.0 4.9 5 0 0 5 5 5 0 Leucine Rich Repeat Homoserine_dh PF00742.14 KOO53505.1 - 3e-34 118.2 0.1 9.9e-19 67.6 0.0 2.3 2 0 0 2 2 2 2 Homoserine dehydrogenase NAD_binding_3 PF03447.11 KOO53505.1 - 1.6e-06 28.4 2.1 3.6e-05 24.1 1.5 2.5 1 1 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain TPT PF03151.11 KOO53506.1 - 2.2e-18 66.3 12.1 4.5e-17 62.0 4.1 2.3 2 0 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.15 KOO53506.1 - 4.3e-07 30.0 22.7 0.00087 19.3 7.0 2.7 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.6 KOO53506.1 - 4.4e-06 25.8 10.0 6.1e-05 22.0 5.9 2.7 2 1 0 2 2 2 1 UAA transporter family EmrE PF13536.1 KOO53506.1 - 0.001 19.2 2.6 0.001 19.2 1.8 3.4 1 1 2 3 3 3 1 Multidrug resistance efflux transporter Nuc_sug_transp PF04142.10 KOO53506.1 - 0.0053 15.8 3.5 0.15 11.1 0.2 2.3 2 0 0 2 2 2 2 Nucleotide-sugar transporter DUF874 PF05917.6 KOO53506.1 - 0.72 8.6 6.3 1 8.1 4.4 1.1 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) Hist_deacetyl PF00850.14 KOO53507.1 - 1.3e-80 270.9 0.0 1.5e-80 270.7 0.0 1.0 1 0 0 1 1 1 1 Histone deacetylase domain Rho_Binding PF08912.6 KOO53508.1 - 0.033 14.4 0.9 0.11 12.8 0.0 2.0 2 0 0 2 2 2 0 Rho Binding DUF2098 PF09871.4 KOO53508.1 - 0.047 13.6 0.1 0.075 12.9 0.1 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) TSA PF03249.8 KOO53508.1 - 0.053 12.0 0.7 0.056 11.9 0.5 1.1 1 0 0 1 1 1 0 Type specific antigen Flg_hook PF02120.11 KOO53508.1 - 0.065 12.9 0.9 3.3 7.4 0.2 2.3 2 0 0 2 2 2 0 Flagellar hook-length control protein FliK DUF904 PF06005.7 KOO53508.1 - 0.067 13.4 0.2 0.091 13.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF904) DASH_Dad2 PF08654.5 KOO53508.1 - 0.11 12.4 2.0 0.27 11.2 1.4 1.8 1 1 0 1 1 1 0 DASH complex subunit Dad2 ERM PF00769.14 KOO53508.1 - 1 8.8 7.0 1.7 8.0 0.8 1.9 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Thioredoxin PF00085.15 KOO53509.1 - 9e-07 28.5 0.0 1.3e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_3 PF13192.1 KOO53509.1 - 0.11 12.2 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin domain Aldedh PF00171.17 KOO53510.1 - 4.6e-38 130.7 3.9 3.9e-20 71.6 0.8 2.0 1 1 1 2 2 2 2 Aldehyde dehydrogenase family zf-H2C2_2 PF13465.1 KOO53511.1 - 4.5e-33 111.9 45.9 8.2e-07 29.0 0.5 7.2 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.21 KOO53511.1 - 1.1e-27 94.6 44.8 0.00017 21.7 1.2 6.4 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 KOO53511.1 - 1.8e-22 77.9 36.1 0.0016 18.6 0.8 6.4 6 0 0 6 6 6 6 C2H2-type zinc finger CHORD PF04968.7 KOO53511.1 - 0.0046 17.1 36.0 3.2 8.0 0.6 6.3 2 1 4 6 6 6 5 CHORD zf-C2H2_6 PF13912.1 KOO53511.1 - 0.61 10.0 28.2 2 8.4 0.1 6.7 6 2 1 7 7 7 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 KOO53511.1 - 0.84 9.8 29.6 5.6 7.2 0.3 6.4 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding META PF03724.11 KOO53512.1 - 0.1 12.4 0.2 0.16 11.8 0.2 1.5 1 0 0 1 1 1 0 META domain SbcCD_C PF13558.1 KOO53512.1 - 0.27 11.1 2.8 0.49 10.3 1.7 1.6 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Sporozoite_P67 PF05642.6 KOO53514.1 - 0.16 9.8 2.8 0.19 9.5 1.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Complex1_49kDa PF00346.14 KOO53515.1 - 1.3e-126 421.1 0.0 1.6e-126 420.8 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit adh_short_C2 PF13561.1 KOO53517.1 - 0.13 12.0 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase TMF_TATA_bd PF12325.3 KOO53518.1 - 0.011 15.4 4.3 0.011 15.4 3.0 3.3 2 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding Pox_A_type_inc PF04508.7 KOO53518.1 - 0.95 9.4 7.5 0.18 11.6 0.5 3.2 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat Mut7-C PF01927.11 KOO53518.1 - 1.1 9.2 5.1 2.8 7.9 3.5 2.1 1 1 0 1 1 1 0 Mut7-C RNAse domain Synaptobrevin PF00957.16 KOO53518.1 - 2.2 7.9 6.9 0.54 9.8 2.2 1.9 2 0 0 2 2 2 0 Synaptobrevin UPF0184 PF03670.8 KOO53518.1 - 2.3 8.4 12.1 3.3 7.9 0.2 3.1 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0184) Reo_sigmaC PF04582.7 KOO53518.1 - 2.7 7.0 10.5 1.6 7.7 1.0 2.6 1 1 2 3 3 3 0 Reovirus sigma C capsid protein AAA_13 PF13166.1 KOO53518.1 - 4.5 5.5 29.3 0.15 10.4 11.5 2.0 1 1 1 2 2 2 0 AAA domain LMP PF04778.7 KOO53519.1 - 0.0074 16.0 0.6 0.0081 15.9 0.4 1.1 1 0 0 1 1 1 1 LMP repeated region KxDL PF10241.4 KOO53519.1 - 0.028 14.3 1.6 0.066 13.1 1.0 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein L27 PF02828.11 KOO53519.1 - 0.14 11.8 1.0 5 6.8 0.3 2.3 2 0 0 2 2 2 0 L27 domain PilO PF04350.8 KOO53519.1 - 0.17 11.7 2.1 0.23 11.3 1.5 1.2 1 0 0 1 1 1 0 Pilus assembly protein, PilO YlqD PF11068.3 KOO53519.1 - 0.26 11.3 5.2 0.29 11.1 3.6 1.1 1 0 0 1 1 1 0 YlqD protein DUF4404 PF14357.1 KOO53519.1 - 0.41 11.0 4.6 0.56 10.6 3.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4404) IFT20 PF14931.1 KOO53519.1 - 0.67 9.8 7.4 0.76 9.6 5.1 1.1 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 KfrA_N PF11740.3 KOO53519.1 - 0.82 10.1 9.9 0.93 9.9 6.9 1.1 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term Methyltransf_21 PF05050.7 KOO53520.1 - 3.5e-23 82.3 0.0 4.1e-14 52.8 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase FkbM domain Methyltransf_22 PF13383.1 KOO53520.1 - 9.4e-11 41.7 0.0 3.4e-10 39.8 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 KOO53520.1 - 0.0008 19.9 0.1 0.93 10.0 0.0 3.2 3 1 0 3 3 3 2 Methyltransferase domain Methyltransf_12 PF08242.7 KOO53520.1 - 0.0032 17.9 0.0 0.01 16.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain FmrO PF07091.6 KOO53520.1 - 0.053 12.5 0.0 0.087 11.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) ABC_tran PF00005.22 KOO53521.1 - 1.2e-37 129.2 0.0 1e-19 71.1 0.0 4.6 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 KOO53521.1 - 7.9e-16 58.8 0.0 0.0013 18.7 0.1 4.3 4 0 0 4 4 4 4 AAA domain SMC_N PF02463.14 KOO53521.1 - 6.2e-10 38.6 0.1 0.048 12.8 0.0 4.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 KOO53521.1 - 1.5e-08 34.0 1.6 0.013 14.5 0.0 4.2 4 0 0 4 4 4 2 AAA ATPase domain SbcCD_C PF13558.1 KOO53521.1 - 2.4e-07 30.5 0.2 0.01 15.7 0.0 3.7 3 2 0 3 3 3 2 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.1 KOO53521.1 - 1.7e-06 28.2 0.0 0.0079 16.3 0.0 3.2 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.1 KOO53521.1 - 2.1e-05 24.9 3.7 0.13 12.6 1.5 3.1 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.1 KOO53521.1 - 3.6e-05 23.2 0.1 0.074 12.5 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain MobB PF03205.9 KOO53521.1 - 5.6e-05 22.8 0.0 0.035 13.7 0.0 2.9 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Miro PF08477.8 KOO53521.1 - 8.4e-05 23.0 0.0 0.3 11.5 0.0 3.3 3 0 0 3 3 3 2 Miro-like protein MMR_HSR1 PF01926.18 KOO53521.1 - 0.0007 19.5 0.0 1.9 8.4 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase DLIC PF05783.6 KOO53521.1 - 0.014 14.0 0.0 0.76 8.3 0.0 2.2 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) AAA PF00004.24 KOO53521.1 - 0.025 14.7 0.0 2.8 8.1 0.0 3.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 KOO53521.1 - 0.055 13.3 0.0 7.6 6.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.1 KOO53521.1 - 0.071 13.0 0.0 10 6.0 0.0 2.8 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.17 KOO53521.1 - 0.11 12.6 0.0 11 6.2 0.0 2.6 2 0 0 2 2 2 0 RNA helicase Dynamin_N PF00350.18 KOO53521.1 - 0.16 11.7 1.1 14 5.5 0.1 3.2 3 1 0 3 3 3 0 Dynamin family Myosin_head PF00063.16 KOO53522.1 - 4.9e-20 71.1 0.0 3.1e-16 58.6 0.0 3.1 3 2 0 3 3 3 2 Myosin head (motor domain) AAA_16 PF13191.1 KOO53522.1 - 0.00011 22.3 1.6 0.0031 17.5 0.0 3.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 KOO53522.1 - 0.017 15.2 0.0 0.06 13.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 KOO53522.1 - 0.048 14.4 0.0 0.13 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 KOO53522.1 - 0.15 11.7 0.0 0.38 10.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_10 PF12846.2 KOO53522.1 - 0.25 10.7 0.0 0.48 9.7 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain Med3 PF11593.3 KOO53523.1 - 0.56 9.3 2.9 0.57 9.3 2.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal ATG16 PF08614.6 KOO53524.1 - 0.00017 21.5 0.1 0.00023 21.0 0.0 1.3 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) DASH_Dam1 PF08653.5 KOO53524.1 - 0.00017 21.2 7.1 0.71 9.6 0.1 3.6 2 1 2 4 4 3 3 DASH complex subunit Dam1 bZIP_1 PF00170.16 KOO53524.1 - 0.00054 19.8 5.4 0.18 11.7 1.3 2.7 1 1 2 3 3 3 3 bZIP transcription factor DUF724 PF05266.9 KOO53524.1 - 0.00062 19.4 3.4 0.00062 19.4 2.3 1.9 1 1 1 2 2 2 2 Protein of unknown function (DUF724) TBPIP PF07106.8 KOO53524.1 - 0.00069 19.2 3.1 0.00069 19.2 2.2 1.5 1 1 1 2 2 2 2 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TMF_DNA_bd PF12329.3 KOO53524.1 - 0.00081 19.1 7.0 0.061 13.1 0.2 2.8 2 2 1 3 3 3 2 TATA element modulatory factor 1 DNA binding Ax_dynein_light PF10211.4 KOO53524.1 - 0.0023 17.7 6.3 0.2 11.4 0.2 2.1 1 1 1 2 2 2 2 Axonemal dynein light chain ERM PF00769.14 KOO53524.1 - 0.0038 16.8 19.0 0.004 16.7 13.1 1.1 1 0 0 1 1 1 1 Ezrin/radixin/moesin family DUF972 PF06156.8 KOO53524.1 - 0.0069 16.7 6.2 0.031 14.6 4.3 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF972) APG6 PF04111.7 KOO53524.1 - 0.014 14.4 7.3 0.021 13.9 5.0 1.4 1 1 0 1 1 1 0 Autophagy protein Apg6 Spc7 PF08317.6 KOO53524.1 - 0.016 13.8 2.3 0.019 13.6 1.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein TMCO5 PF14992.1 KOO53524.1 - 0.021 13.9 9.0 0.025 13.7 6.3 1.1 1 0 0 1 1 1 0 TMCO5 family Myosin_tail_1 PF01576.14 KOO53524.1 - 0.043 11.5 11.6 0.05 11.3 8.1 1.1 1 0 0 1 1 1 0 Myosin tail V_ATPase_I PF01496.14 KOO53524.1 - 0.074 10.9 3.1 0.076 10.8 2.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Mnd1 PF03962.10 KOO53524.1 - 0.089 12.4 3.6 0.12 12.0 2.5 1.3 1 0 0 1 1 1 0 Mnd1 family Prefoldin_2 PF01920.15 KOO53524.1 - 0.095 12.4 5.4 0.49 10.1 0.3 2.8 1 1 2 3 3 3 0 Prefoldin subunit PilJ PF13675.1 KOO53524.1 - 0.11 12.8 0.3 0.23 11.7 0.2 1.7 1 1 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF4140 PF13600.1 KOO53524.1 - 0.11 12.9 8.2 0.67 10.4 0.5 2.7 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) AAA_13 PF13166.1 KOO53524.1 - 0.12 10.8 0.0 0.19 10.1 0.0 1.3 1 1 0 1 1 1 0 AAA domain DUF812 PF05667.6 KOO53524.1 - 0.16 10.4 9.1 0.21 10.0 6.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) GAS PF13851.1 KOO53524.1 - 0.2 10.8 4.4 0.35 10.0 3.0 1.6 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Cortex-I_coil PF09304.5 KOO53524.1 - 0.25 11.4 5.5 0.58 10.2 3.7 1.7 1 1 0 1 1 1 0 Cortexillin I, coiled coil Bac_GDH PF05088.7 KOO53524.1 - 0.29 8.4 4.4 0.31 8.3 3.0 1.0 1 0 0 1 1 1 0 Bacterial NAD-glutamate dehydrogenase Seryl_tRNA_N PF02403.17 KOO53524.1 - 0.3 11.1 10.9 0.18 11.8 2.5 2.9 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Spc24 PF08286.6 KOO53524.1 - 0.35 10.5 5.6 2.7 7.6 3.9 2.2 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 GrpE PF01025.14 KOO53524.1 - 0.35 10.3 12.5 1.3 8.5 0.9 2.1 1 1 1 2 2 2 0 GrpE Lebercilin PF15619.1 KOO53524.1 - 0.46 9.8 5.0 4.2 6.7 2.9 1.9 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease M PF02370.11 KOO53524.1 - 1.1 9.8 12.1 1.3e+02 3.5 0.2 5.4 2 2 4 6 6 6 0 M protein repeat DUF904 PF06005.7 KOO53524.1 - 1.3 9.4 7.9 5.1 7.4 0.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF904) DUF4200 PF13863.1 KOO53524.1 - 1.3 9.0 7.5 2 8.3 0.1 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) TPR_MLP1_2 PF07926.7 KOO53524.1 - 1.4 8.6 6.7 19 5.0 4.6 2.2 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein TMF_TATA_bd PF12325.3 KOO53524.1 - 1.6 8.5 11.0 0.093 12.4 2.9 2.0 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding CENP-F_leu_zip PF10473.4 KOO53524.1 - 1.9 8.3 13.8 2.9 7.7 9.5 1.4 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tropomyosin_1 PF12718.2 KOO53524.1 - 2.1 8.1 11.2 4.1 7.2 7.5 1.6 1 1 0 1 1 1 0 Tropomyosin like CENP-Q PF13094.1 KOO53524.1 - 4.2 7.3 9.8 5.9 6.8 6.8 1.3 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit PEARLI-4 PF05278.7 KOO53524.1 - 4.4 6.5 10.9 0.79 9.0 4.4 1.9 1 1 1 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) Cytochrom_B562 PF07361.6 KOO53524.1 - 6.3 7.2 8.6 1.8 9.0 1.3 2.5 1 1 1 2 2 2 0 Cytochrome b562 EF-hand_6 PF13405.1 KOO53526.1 - 0.0011 18.6 0.1 0.0017 18.1 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.1 KOO53526.1 - 0.0038 16.5 1.0 0.0057 15.9 0.7 1.3 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KOO53526.1 - 0.0044 16.2 1.0 0.0068 15.6 0.7 1.3 1 0 0 1 1 1 1 EF hand DUF3918 PF13056.1 KOO53526.1 - 0.019 14.2 1.4 0.027 13.7 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3918) EF-hand_7 PF13499.1 KOO53526.1 - 0.022 14.8 0.0 0.023 14.8 0.0 1.2 1 0 0 1 1 1 0 EF-hand domain pair DUF2866 PF11065.3 KOO53527.1 - 0.024 14.5 0.1 0.048 13.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2866) EphA2_TM PF14575.1 KOO53527.1 - 1.8 8.9 4.3 0.47 10.8 0.2 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain EF-hand_1 PF00036.27 KOO53528.1 - 2.9e-09 35.5 0.8 0.00018 20.5 0.1 4.9 5 0 0 5 5 5 2 EF hand EF-hand_6 PF13405.1 KOO53528.1 - 1.2e-06 27.8 0.2 0.002 17.8 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.1 KOO53528.1 - 1.6e-05 24.9 2.1 0.00029 20.8 0.1 3.3 3 2 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO53528.1 - 0.0027 16.9 3.3 0.033 13.5 0.1 3.8 5 0 0 5 5 5 1 EF hand EF-hand_8 PF13833.1 KOO53528.1 - 0.0087 15.6 0.8 0.2 11.2 0.1 3.1 2 1 0 2 2 2 1 EF-hand domain pair IstB_IS21_ATP PF08483.6 KOO53528.1 - 0.037 13.7 0.1 0.088 12.4 0.1 1.6 1 0 0 1 1 1 0 IstB-like ATP binding N-terminal UQ_con PF00179.21 KOO53531.1 - 2e-25 88.8 0.0 2.5e-25 88.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 KOO53531.1 - 0.045 13.5 0.0 0.068 12.9 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.17 KOO53531.1 - 0.079 12.8 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 RWD domain Na_Ca_ex PF01699.19 KOO53532.1 - 7.2e-38 129.3 35.4 7.5e-21 74.1 7.2 2.8 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Calx-beta PF03160.9 KOO53532.1 - 2e-19 69.3 2.2 5e-17 61.7 0.7 2.3 2 0 0 2 2 2 2 Calx-beta domain TP6A_N PF04406.9 KOO53533.1 - 2.5e-19 68.7 0.0 4.2e-19 67.9 0.0 1.4 1 0 0 1 1 1 1 Type IIB DNA topoisomerase MoaC PF01967.16 KOO53534.1 - 3.9e-54 181.9 2.9 4.5e-54 181.8 2.0 1.0 1 0 0 1 1 1 1 MoaC family gag_pre-integrs PF13976.1 KOO53536.1 - 1.1e-06 28.1 0.1 3.1e-06 26.7 0.0 1.8 2 0 0 2 2 2 1 GAG-pre-integrase domain rve PF00665.21 KOO53536.1 - 0.0099 15.9 0.0 0.024 14.7 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Glyco_hydro_2_N PF02837.13 KOO53537.1 - 1.7e-15 57.0 0.0 2e-13 50.2 0.0 2.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.16 KOO53537.1 - 3.5e-05 24.2 0.0 7.5e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 RPA_interact_C PF14768.1 KOO53538.1 - 0.12 12.7 0.1 0.2 12.0 0.1 1.4 1 0 0 1 1 1 0 Replication protein A interacting C-terminal PAE PF03283.8 KOO53539.1 - 5.5e-59 199.6 0.0 7.4e-59 199.1 0.0 1.1 1 0 0 1 1 1 1 Pectinacetylesterase Glyco_hydro_2_C PF02836.12 KOO53539.1 - 5.5e-05 22.2 0.0 0.0001 21.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Macoilin PF09726.4 KOO53540.1 - 0.76 7.9 7.6 1 7.5 5.3 1.1 1 0 0 1 1 1 0 Transmembrane protein Spore_coat_CotO PF14153.1 KOO53540.1 - 1.2 8.5 5.3 1.5 8.2 3.7 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Borrelia_P83 PF05262.6 KOO53540.1 - 3.1 5.9 10.3 3.8 5.6 7.2 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein SHIPPO-rpt PF07004.7 KOO53541.1 - 0.00037 21.2 4.6 3.4 8.7 0.0 4.6 4 0 0 4 4 4 2 Sperm-tail PG-rich repeat EF-hand_1 PF00036.27 KOO53542.1 - 2.4e-05 23.3 0.1 4.4e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO53542.1 - 0.00016 21.2 0.0 0.00034 20.2 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.1 KOO53542.1 - 0.0014 18.7 0.0 0.0029 17.7 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO53542.1 - 0.0048 16.1 0.1 0.0097 15.2 0.0 1.4 1 0 0 1 1 1 1 EF hand Glyco_transf_20 PF00982.16 KOO53544.1 - 1.5e-102 343.5 0.0 2e-102 343.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 KOO53544.1 - 7.5e-38 129.7 0.0 1.3e-37 128.9 0.0 1.4 1 0 0 1 1 1 1 Trehalose-phosphatase TPR_19 PF14559.1 KOO53545.1 - 8.5e-09 35.6 20.4 0.00047 20.4 2.2 4.9 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO53545.1 - 4.6e-08 32.5 7.8 3.1e-05 23.5 0.9 3.1 3 1 0 3 3 3 2 TPR repeat TPR_8 PF13181.1 KOO53545.1 - 0.0034 17.0 0.0 0.18 11.6 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 KOO53545.1 - 0.0038 17.0 13.0 0.2 11.6 0.4 4.7 6 1 1 7 7 6 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO53545.1 - 0.0042 16.9 15.3 0.18 11.7 0.9 4.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO53545.1 - 0.0066 17.0 30.0 0.019 15.6 2.2 5.0 5 1 1 6 6 6 2 Tetratricopeptide repeat RPN7 PF10602.4 KOO53545.1 - 0.0086 15.4 0.1 0.069 12.5 0.0 2.0 2 0 0 2 2 2 1 26S proteasome subunit RPN7 TPR_1 PF00515.23 KOO53545.1 - 0.032 13.8 3.4 3 7.5 0.1 3.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO53545.1 - 0.032 14.8 4.5 0.032 14.8 3.1 6.3 4 2 3 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.1 KOO53545.1 - 0.085 13.3 10.0 0.74 10.4 1.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO53545.1 - 0.45 10.4 14.7 2.8 7.9 2.6 5.3 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_9 PF13371.1 KOO53545.1 - 0.57 10.0 15.0 1.1 9.1 0.8 4.2 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.9 KOO53545.1 - 5.3 7.7 14.8 0.12 12.9 3.3 3.7 4 1 0 4 4 3 0 Tetratricopeptide repeat Apc3 PF12895.2 KOO53545.1 - 7.6 6.7 11.2 2.3 8.4 0.6 3.6 2 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Pkinase PF00069.20 KOO53547.1 - 2.1e-41 141.7 0.0 2.5e-41 141.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO53547.1 - 6.2e-33 113.9 0.0 7.6e-33 113.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase MOZART1 PF12554.3 KOO53547.1 - 0.0096 15.3 0.1 0.07 12.6 0.2 2.1 2 0 0 2 2 2 1 Mitotic-spindle organizing gamma-tubulin ring associated Kinase-like PF14531.1 KOO53547.1 - 0.048 12.6 0.0 0.064 12.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like IlvN PF07991.7 KOO53547.1 - 0.059 12.7 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain APH PF01636.18 KOO53547.1 - 0.17 11.6 3.8 0.25 11.0 2.6 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Remorin_C PF03763.8 KOO53548.1 - 1.1 8.8 7.6 1.8 8.1 5.3 1.3 1 0 0 1 1 1 0 Remorin, C-terminal region Pkinase PF00069.20 KOO53550.1 - 1.4e-42 145.6 0.0 2.1e-42 145.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO53550.1 - 2.8e-19 69.2 0.0 4e-19 68.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RPAP3_C PF13877.1 KOO53550.1 - 0.18 11.8 0.0 0.46 10.4 0.0 1.7 1 0 0 1 1 1 0 Potential Monad-binding region of RPAP3 SPRY PF00622.23 KOO53551.1 - 0.021 14.8 0.0 0.041 13.9 0.0 1.4 1 0 0 1 1 1 0 SPRY domain LRR_6 PF13516.1 KOO53551.1 - 0.35 11.0 3.0 1.2e+02 3.2 0.1 4.0 3 0 0 3 3 3 0 Leucine Rich repeat TylF PF05711.6 KOO53553.1 - 0.00035 19.7 0.0 0.00055 19.0 0.0 1.3 1 1 0 1 1 1 1 Macrocin-O-methyltransferase (TylF) DUF4218 PF13960.1 KOO53555.1 - 0.0011 18.3 1.0 0.0022 17.4 0.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) DUF4248 PF14053.1 KOO53555.1 - 0.066 12.7 0.0 0.21 11.2 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4248) Mnd1 PF03962.10 KOO53555.1 - 0.069 12.8 0.1 0.18 11.4 0.0 1.7 2 0 0 2 2 2 0 Mnd1 family PGM_PMM_I PF02878.11 KOO53557.1 - 5e-29 100.5 0.0 9.7e-29 99.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.11 KOO53557.1 - 5.3e-23 81.2 0.0 1.2e-22 80.0 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.11 KOO53557.1 - 2e-10 40.8 0.1 7e-10 39.1 0.0 1.9 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 KOO53557.1 - 2.4e-08 33.8 0.0 6e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Dpy-30 PF05186.8 KOO53557.1 - 0.0038 16.6 0.4 0.013 15.0 0.0 2.1 2 0 0 2 2 2 1 Dpy-30 motif Dpy-30 PF05186.8 KOO53558.1 - 6e-05 22.4 0.3 0.0018 17.7 0.0 2.8 3 0 0 3 3 3 1 Dpy-30 motif Collagen PF01391.13 KOO53558.1 - 0.0033 16.9 6.9 0.0057 16.1 4.8 1.3 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) RIIa PF02197.12 KOO53558.1 - 0.0075 15.6 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit OmpA PF00691.15 KOO53558.1 - 0.048 14.0 0.1 0.28 11.6 0.1 2.0 2 0 0 2 2 2 0 OmpA family PRA1 PF03208.14 KOO53559.1 - 8.7e-26 90.0 1.3 1.1e-25 89.7 0.9 1.0 1 0 0 1 1 1 1 PRA1 family protein DUF4131 PF13567.1 KOO53559.1 - 1.4 8.3 7.2 2.1 7.7 5.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) PI-PLC-X PF00388.14 KOO53560.1 - 0.00024 20.5 0.0 0.00067 19.0 0.0 1.7 1 1 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain WD40 PF00400.27 KOO53561.1 - 1e-12 47.4 0.8 0.033 14.0 0.0 7.5 8 0 0 8 8 8 3 WD domain, G-beta repeat eIF2A PF08662.6 KOO53561.1 - 2.3e-08 34.0 0.0 0.024 14.3 0.0 5.2 3 2 0 4 4 4 1 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.7 KOO53561.1 - 0.00015 19.7 0.2 0.39 8.4 0.1 4.0 2 2 0 3 3 3 3 IKI3 family Proteasome_A_N PF10584.4 KOO53561.1 - 0.00039 19.6 1.0 1.1 8.6 0.0 3.9 3 0 0 3 3 3 2 Proteasome subunit A N-terminal signature Capsule_synth PF05159.9 KOO53562.1 - 2.5e-08 33.7 0.0 3.7e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Capsule polysaccharide biosynthesis protein TIG PF01833.19 KOO53563.1 - 6.1e-16 58.1 1.9 8.7e-12 44.8 0.1 4.1 4 0 0 4 4 4 3 IPT/TIG domain Glyco_transf_49 PF13896.1 KOO53564.1 - 2e-17 63.2 0.1 3.2e-08 33.0 0.0 3.1 2 1 1 3 3 3 3 Glycosyl-transferase for dystroglycan NAP PF00956.13 KOO53565.1 - 1.8e-31 109.1 0.0 2.4e-31 108.7 0.0 1.2 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) KIP1 PF07765.7 KOO53565.1 - 0.1 12.4 0.0 0.49 10.2 0.0 2.0 2 0 0 2 2 2 0 KIP1-like protein Exostosin PF03016.10 KOO53566.1 - 9.6e-17 60.9 0.0 1.4e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 Exostosin family C2 PF00168.25 KOO53567.1 - 2.3e-16 59.4 0.0 5.1e-16 58.2 0.0 1.6 1 0 0 1 1 1 1 C2 domain zf-C2HC_2 PF13913.1 KOO53567.1 - 2.9e-16 58.6 9.0 1.3e-08 34.2 0.3 2.5 2 0 0 2 2 2 2 zinc-finger of a C2HC-type Ion_trans PF00520.26 KOO53567.1 - 5.3e-10 38.8 3.8 5.3e-10 38.8 2.6 1.8 2 0 0 2 2 2 1 Ion transport protein cNMP_binding PF00027.24 KOO53567.1 - 0.0025 17.6 0.0 0.0059 16.3 0.0 1.7 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain zf-C2H2 PF00096.21 KOO53567.1 - 0.0063 16.7 2.0 1.2 9.5 0.2 2.8 2 0 0 2 2 2 1 Zinc finger, C2H2 type Ion_trans_N PF08412.5 KOO53567.1 - 0.0083 15.4 0.0 0.024 13.9 0.0 1.8 1 0 0 1 1 1 1 Ion transport protein N-terminal zinc_ribbon_5 PF13719.1 KOO53567.1 - 0.015 14.8 0.5 0.36 10.4 0.0 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zf-BED PF02892.10 KOO53567.1 - 0.022 14.5 0.1 4.2 7.2 0.1 2.5 2 0 0 2 2 2 0 BED zinc finger zinc_ribbon_4 PF13717.1 KOO53567.1 - 0.035 13.7 0.4 0.75 9.5 0.0 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zf-H2C2_2 PF13465.1 KOO53567.1 - 0.085 13.1 0.3 3.2 8.1 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger double domain FYVE PF01363.16 KOO53567.1 - 0.12 12.3 3.2 9.7 6.1 0.1 2.5 2 0 0 2 2 2 0 FYVE zinc finger Dscam_C PF12355.3 KOO53567.1 - 0.12 12.5 1.5 0.33 11.2 1.0 1.6 1 0 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal Sulfotransfer_1 PF00685.22 KOO53567.1 - 0.26 10.4 4.3 1.7 7.8 1.4 2.4 2 0 0 2 2 2 0 Sulfotransferase domain zf-C2H2_4 PF13894.1 KOO53567.1 - 0.74 10.2 6.0 7.8 7.0 0.3 3.0 3 0 0 3 3 2 0 C2H2-type zinc finger Sgf11 PF08209.6 KOO53567.1 - 5.1 6.4 7.0 12 5.2 0.4 2.4 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Dus PF01207.12 KOO53568.1 - 7.5e-46 156.3 0.0 3.8e-38 131.0 0.0 2.3 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) zf-CCCH PF00642.19 KOO53568.1 - 3.8e-05 23.2 11.5 0.0017 18.0 0.6 2.9 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 KOO53568.1 - 3.9 7.6 6.0 8 6.6 0.1 3.4 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type Kinesin PF00225.18 KOO53570.1 - 1.3e-81 273.9 0.0 2e-81 273.3 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain TPR_12 PF13424.1 KOO53570.1 - 1.4e-42 143.5 1.0 1.4e-17 63.3 0.1 3.1 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.1 KOO53570.1 - 4.1e-29 99.6 1.9 3e-09 36.5 0.1 4.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.1 KOO53570.1 - 4.6e-13 47.9 1.3 0.00013 21.4 0.0 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.1 KOO53570.1 - 9.1e-13 47.6 0.2 1.1e-09 37.7 0.1 3.1 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 KOO53570.1 - 1.8e-12 46.3 3.1 0.00055 19.4 0.1 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 KOO53570.1 - 9.4e-11 40.7 2.9 0.0015 18.2 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO53570.1 - 0.00018 22.0 1.7 0.00018 22.0 1.2 4.2 4 2 1 5 5 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO53570.1 - 0.00036 20.9 15.6 0.075 13.7 0.1 5.5 4 1 2 6 6 3 2 Tetratricopeptide repeat AAA_22 PF13401.1 KOO53570.1 - 0.0052 16.9 0.1 0.083 13.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain TPR_8 PF13181.1 KOO53570.1 - 0.0068 16.1 0.1 2.2 8.2 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF2225 PF09986.4 KOO53570.1 - 0.097 12.1 0.0 18 4.6 0.0 2.7 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) AAA_13 PF13166.1 KOO53570.1 - 1.1 7.6 8.9 0.16 10.4 0.8 2.2 2 0 0 2 2 2 0 AAA domain GAS PF13851.1 KOO53570.1 - 1.2 8.2 12.6 0.5 9.5 1.9 2.5 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding APG6 PF04111.7 KOO53570.1 - 1.6 7.7 14.1 0.96 8.4 3.6 2.4 2 0 0 2 2 2 0 Autophagy protein Apg6 TPR_4 PF07721.9 KOO53570.1 - 2 9.0 0.0 2 9.0 0.0 5.5 6 0 0 6 6 5 0 Tetratricopeptide repeat IncA PF04156.9 KOO53570.1 - 7.1 6.1 13.6 0.52 9.8 1.9 2.3 2 0 0 2 2 2 0 IncA protein Alg14 PF08660.6 KOO53571.1 - 1.3 9.0 3.3 2.2 8.2 0.2 2.5 1 1 0 2 2 2 0 Oligosaccharide biosynthesis protein Alg14 like ACBP PF00887.14 KOO53572.1 - 0.12 12.0 0.1 0.12 12.0 0.1 1.9 2 0 0 2 2 2 0 Acyl CoA binding protein Arf PF00025.16 KOO53574.1 - 2.5e-65 218.9 1.3 1.4e-62 210.0 0.9 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 KOO53574.1 - 1e-08 34.7 0.0 9.5e-08 31.5 0.0 2.0 1 1 0 1 1 1 1 Ras family G-alpha PF00503.15 KOO53574.1 - 2.4e-07 29.8 0.9 0.00051 18.8 0.1 2.5 2 1 1 3 3 3 2 G-protein alpha subunit SRPRB PF09439.5 KOO53574.1 - 3.4e-07 29.6 0.1 4.6e-06 25.9 0.0 2.0 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 KOO53574.1 - 1.3e-05 24.4 0.0 1.6e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 KOO53574.1 - 0.0028 18.1 0.1 0.0063 16.9 0.0 1.7 1 1 0 1 1 1 1 Miro-like protein 6PF2K PF01591.13 KOO53574.1 - 0.0092 15.0 0.0 0.011 14.8 0.0 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase MMR_HSR1 PF01926.18 KOO53574.1 - 0.012 15.5 0.0 0.016 15.1 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_33 PF13671.1 KOO53574.1 - 0.048 13.5 0.1 0.083 12.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain UQ_con PF00179.21 KOO53575.1 - 4.9e-12 45.4 0.0 1e-11 44.4 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme zf-C3HC4_2 PF13923.1 KOO53575.1 - 3e-06 27.1 7.4 6.5e-06 26.0 5.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 KOO53575.1 - 4.3e-06 26.4 6.2 8.7e-06 25.4 4.3 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 KOO53575.1 - 6.7e-06 25.6 6.9 1.4e-05 24.6 4.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 KOO53575.1 - 0.00034 20.2 6.9 0.0006 19.4 4.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-HYPF PF07503.7 KOO53575.1 - 0.00067 19.0 3.6 0.0015 17.9 0.4 2.4 2 0 0 2 2 2 1 HypF finger zf-RING_UBOX PF13445.1 KOO53575.1 - 0.0017 17.9 2.6 0.0035 17.0 1.8 1.5 1 0 0 1 1 1 1 RING-type zinc-finger Prok-E2_B PF14461.1 KOO53575.1 - 0.0018 18.0 0.0 0.0048 16.6 0.0 1.6 1 0 0 1 1 1 1 Prokaryotic E2 family B zf-C3HC4_4 PF15227.1 KOO53575.1 - 0.0023 17.7 5.6 0.0054 16.5 3.9 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.1 KOO53575.1 - 0.013 15.2 2.8 0.038 13.7 1.9 1.7 1 1 0 1 1 1 0 zf-RING of BARD1-type protein zf-rbx1 PF12678.2 KOO53575.1 - 0.019 15.0 1.2 0.037 14.1 0.8 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger RWD PF05773.17 KOO53575.1 - 0.024 14.5 0.0 0.047 13.5 0.0 1.4 1 0 0 1 1 1 0 RWD domain FYVE PF01363.16 KOO53575.1 - 0.13 12.1 6.3 0.24 11.3 4.4 1.4 1 0 0 1 1 1 0 FYVE zinc finger Orai-1 PF07856.7 KOO53575.1 - 0.43 10.1 8.8 1.2 8.7 6.1 1.6 1 1 0 1 1 1 0 Mediator of CRAC channel activity Fer2 PF00111.22 KOO53575.1 - 1.1 9.1 4.9 3 7.6 3.3 1.8 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain zf-RING_4 PF14570.1 KOO53575.1 - 1.8 8.2 5.2 3.7 7.1 3.6 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-CHY PF05495.7 KOO53575.1 - 2.4 8.4 6.6 11 6.2 4.3 2.0 1 1 1 2 2 2 0 CHY zinc finger Mob_synth_C PF06463.8 KOO53576.1 - 1.3e-35 121.9 0.0 2.2e-35 121.1 0.0 1.4 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.16 KOO53576.1 - 3.7e-23 82.5 0.0 6.8e-23 81.6 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.1 KOO53576.1 - 3.4e-06 27.2 0.0 6.1e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.1 KOO53576.1 - 5.3e-06 26.4 0.0 1.3e-05 25.1 0.0 1.6 2 0 0 2 2 2 1 4Fe-4S single cluster domain Mg_trans_NIPA PF05653.9 KOO53577.1 - 4.8e-14 52.0 3.9 1.1e-09 37.6 0.2 2.2 2 0 0 2 2 2 2 Magnesium transporter NIPA UPF0546 PF10639.4 KOO53577.1 - 0.022 14.5 0.2 0.022 14.5 0.1 2.7 3 0 0 3 3 3 0 Uncharacterised protein family UPF0546 EamA PF00892.15 KOO53577.1 - 0.022 14.7 2.4 0.022 14.7 1.7 3.8 4 1 0 4 4 4 0 EamA-like transporter family Homeobox_KN PF05920.6 KOO53578.1 - 2.7e-14 52.5 0.1 2.7e-14 52.5 0.1 1.4 2 0 0 2 2 2 1 Homeobox KN domain Homeobox PF00046.24 KOO53578.1 - 1.5e-07 30.8 0.2 2.1e-07 30.4 0.1 1.4 1 1 0 1 1 1 1 Homeobox domain Homez PF11569.3 KOO53578.1 - 0.0038 16.2 0.2 0.0058 15.6 0.2 1.3 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez PSII_Pbs27 PF13326.1 KOO53578.1 - 0.0079 16.1 0.0 0.0091 15.9 0.0 1.0 1 0 0 1 1 1 1 Photosystem II Pbs27 FBP PF07299.6 KOO53578.1 - 0.032 13.5 0.0 0.035 13.4 0.0 1.0 1 0 0 1 1 1 0 Fibronectin-binding protein (FBP) Ketoacyl-synt_2 PF13723.1 KOO53578.1 - 0.057 12.6 0.0 0.065 12.4 0.0 1.1 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain FAD_binding_7 PF03441.9 KOO53579.1 - 6e-67 225.7 1.1 8.1e-67 225.3 0.8 1.1 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.13 KOO53579.1 - 7.7e-32 110.3 0.0 2.1e-31 108.9 0.0 1.7 2 0 0 2 2 2 1 DNA photolyase EF-hand_6 PF13405.1 KOO53580.1 - 1.4e-24 83.6 3.7 3.5e-05 23.3 0.0 4.9 5 0 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.27 KOO53580.1 - 5.8e-24 81.5 11.1 1.9e-06 26.7 0.2 5.0 5 0 0 5 5 5 4 EF hand EF-hand_5 PF13202.1 KOO53580.1 - 8.8e-20 69.0 16.9 1.8e-07 30.1 0.4 5.1 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.1 KOO53580.1 - 8.9e-19 67.3 4.3 3e-06 27.2 0.1 3.9 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO53580.1 - 2.3e-17 62.3 7.4 2.5e-09 36.6 0.1 4.4 2 2 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO53580.1 - 0.003 17.5 0.1 11 6.0 0.0 3.5 2 2 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.13 KOO53580.1 - 2.3 8.0 8.3 19 5.1 1.6 3.5 3 0 0 3 3 3 0 Dockerin type I repeat Arm PF00514.18 KOO53581.1 - 6.8e-20 70.1 1.4 4.3e-08 32.7 0.0 3.3 3 0 0 3 3 3 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO53581.1 - 7e-06 26.2 16.5 8.3e-06 26.0 5.7 3.1 1 1 1 2 2 2 2 HEAT repeats Succ_CoA_lig PF13607.1 KOO53581.1 - 0.0085 15.7 1.7 0.0085 15.7 1.2 2.1 1 1 1 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain HEAT PF02985.17 KOO53581.1 - 0.029 14.4 0.7 11 6.3 0.0 3.6 4 0 0 4 4 4 0 HEAT repeat EF-1_beta_acid PF10587.4 KOO53581.1 - 9.3 6.4 12.1 5.9 7.1 6.1 2.5 2 0 0 2 2 2 0 Eukaryotic elongation factor 1 beta central acidic region PEX11 PF05648.9 KOO53582.1 - 0.0017 17.6 0.3 0.0041 16.4 0.1 1.7 2 0 0 2 2 2 1 Peroxisomal biogenesis factor 11 (PEX11) EAF PF09816.4 KOO53583.1 - 0.0017 18.2 0.0 0.0038 17.1 0.0 1.5 2 0 0 2 2 2 1 RNA polymerase II transcription elongation factor Ytp1 PF10355.4 KOO53584.1 - 0.00024 20.3 0.0 0.00032 19.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) TctB PF07331.6 KOO53584.1 - 0.006 16.2 2.5 0.06 13.0 1.7 2.1 1 1 0 1 1 1 1 Tripartite tricarboxylate transporter TctB family NIL PF09383.5 KOO53584.1 - 0.1 12.1 0.0 0.25 10.9 0.0 1.6 1 0 0 1 1 1 0 NIL domain DUF308 PF03729.8 KOO53584.1 - 4.1 7.4 7.4 0.48 10.4 0.4 2.5 2 1 0 2 2 2 0 Short repeat of unknown function (DUF308) Methyltransf_8 PF05148.10 KOO53586.1 - 1.9e-73 246.7 0.0 2.2e-73 246.5 0.0 1.0 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.7 KOO53586.1 - 3.2e-05 24.3 0.1 0.00012 22.4 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 KOO53586.1 - 0.00056 19.5 0.0 0.015 14.8 0.0 2.3 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 KOO53586.1 - 0.0044 16.7 0.0 0.02 14.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 KOO53586.1 - 0.0062 15.9 0.1 0.025 13.9 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase small domain 2OG-FeII_Oxy_3 PF13640.1 KOO53587.1 - 0.00012 22.4 0.0 0.00019 21.8 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 KOO53587.1 - 0.074 13.3 0.0 0.3 11.3 0.0 1.8 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily LSM PF01423.17 KOO53588.1 - 2.9e-15 55.5 0.1 3.8e-15 55.1 0.1 1.2 1 0 0 1 1 1 1 LSM domain HEAT_2 PF13646.1 KOO53589.1 - 6.8e-15 55.1 12.9 3.6e-08 33.5 1.2 3.5 2 2 2 4 4 4 2 HEAT repeats HEAT PF02985.17 KOO53589.1 - 4.2e-10 38.8 7.6 0.025 14.6 0.0 6.1 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.1 KOO53589.1 - 4.7e-06 26.9 11.5 0.38 11.3 0.1 5.5 3 1 3 6 6 6 3 HEAT-like repeat THDPS_N_2 PF14805.1 KOO53589.1 - 0.0039 17.0 5.3 4 7.3 0.0 4.5 4 0 0 4 4 4 1 Tetrahydrodipicolinate N-succinyltransferase N-terminal Peptidase_S9 PF00326.16 KOO53589.1 - 0.0082 15.3 2.3 1.3 8.1 0.0 3.1 1 1 1 3 3 3 1 Prolyl oligopeptidase family Arm PF00514.18 KOO53589.1 - 0.013 15.2 2.0 7.6 6.5 0.0 3.7 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Gluconate_2-dh3 PF13618.1 KOO53589.1 - 0.014 15.5 2.8 0.19 11.8 1.4 2.8 1 1 1 2 2 2 0 Gluconate 2-dehydrogenase subunit 3 Cnd1 PF12717.2 KOO53589.1 - 0.08 12.7 2.1 1.7 8.4 0.1 2.9 1 1 2 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Imm34 PF15596.1 KOO53589.1 - 0.11 12.6 0.9 33 4.6 0.0 4.2 2 1 2 4 4 4 0 Immunity protein 34 ERAP1_C PF11838.3 KOO53589.1 - 0.26 10.4 4.9 0.39 9.9 3.4 1.4 1 1 0 1 1 1 0 ERAP1-like C-terminal domain Toxin_39 PF15500.1 KOO53589.1 - 0.61 10.2 5.8 3.8 7.7 0.1 3.7 1 1 4 5 5 5 0 Putative RNase-like toxin Cohesin_HEAT PF12765.2 KOO53589.1 - 0.76 9.7 4.3 6.2 6.8 0.2 3.4 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion ADPrib_exo_Tox PF03496.9 KOO53590.1 - 7.6e-10 38.3 0.0 3.9e-09 36.0 0.0 2.1 2 1 0 2 2 2 1 ADP-ribosyltransferase exoenzyme ART PF01129.13 KOO53590.1 - 4.8e-08 32.3 0.0 9.6e-08 31.4 0.0 1.4 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Phage_integrase PF00589.17 KOO53591.1 - 0.00046 19.8 0.0 0.00067 19.3 0.0 1.2 1 0 0 1 1 1 1 Phage integrase family Peptidase_M20 PF01546.23 KOO53592.1 - 1.2e-11 44.5 0.1 2.2e-11 43.6 0.1 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.12 KOO53592.1 - 0.045 13.5 0.0 0.083 12.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 U-box PF04564.10 KOO53593.1 - 1.6e-10 40.7 0.0 6.7e-10 38.7 0.0 1.8 2 0 0 2 2 2 1 U-box domain zf-Nse PF11789.3 KOO53593.1 - 0.0019 17.6 0.0 0.0034 16.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Actin PF00022.14 KOO53594.1 - 4.4e-158 525.8 0.0 5e-158 525.6 0.0 1.0 1 0 0 1 1 1 1 Actin ESSS PF10183.4 KOO53594.1 - 0.08 13.3 0.1 0.25 11.7 0.0 1.8 1 1 1 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) RVT_2 PF07727.9 KOO53595.1 - 7.2e-05 21.8 0.0 0.00092 18.2 0.0 2.2 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DEC-1_N PF04625.8 KOO53597.1 - 2.6 6.6 6.5 3.6 6.1 4.5 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Trp_Tyr_perm PF03222.8 KOO53599.1 - 9.7e-21 74.0 1.7 7e-10 38.2 0.3 2.0 2 0 0 2 2 2 2 Tryptophan/tyrosine permease family Galactosyl_T PF01762.16 KOO53600.1 - 0.0014 18.2 0.0 0.0023 17.5 0.0 1.3 1 0 0 1 1 1 1 Galactosyltransferase THOC7 PF05615.8 KOO53604.1 - 0.8 9.9 5.5 1.1 9.4 3.5 1.5 1 1 0 1 1 1 0 Tho complex subunit 7 DUF1657 PF07870.6 KOO53604.1 - 1 9.1 7.2 0.27 10.9 0.4 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1657) Pro_isomerase PF00160.16 KOO53605.1 - 6.1e-34 117.4 0.0 1e-33 116.7 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD IQ PF00612.22 KOO53605.1 - 2.5e-05 23.4 1.2 0.0047 16.4 0.0 2.4 2 0 0 2 2 2 2 IQ calmodulin-binding motif PIF1 PF05970.9 KOO53606.1 - 7.3e-12 44.9 0.0 3.1e-10 39.5 0.0 2.1 2 0 0 2 2 2 2 PIF1-like helicase Herpes_Helicase PF02689.9 KOO53606.1 - 0.00012 20.0 0.0 0.00016 19.5 0.0 1.1 1 0 0 1 1 1 1 Helicase UvrD_C_2 PF13538.1 KOO53606.1 - 0.00073 19.6 0.0 0.0029 17.7 0.0 1.9 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain DUF445 PF04286.7 KOO53607.1 - 1.2e-11 44.8 0.8 2.1e-09 37.4 0.0 2.8 2 1 1 3 3 3 2 Protein of unknown function (DUF445) UreF PF01730.11 KOO53607.1 - 0.031 14.3 0.1 0.062 13.4 0.1 1.4 1 0 0 1 1 1 0 UreF Romo1 PF10247.4 KOO53607.1 - 0.31 11.2 2.3 0.73 10.0 0.0 2.4 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 DUF399 PF04187.8 KOO53608.1 - 2.7e-09 36.8 0.2 1.2e-07 31.4 0.2 2.3 1 1 0 2 2 2 2 Protein of unknown function, DUF399 EcKinase PF02958.15 KOO53609.1 - 9.4e-12 44.6 0.9 1.9e-10 40.4 0.0 2.4 2 0 0 2 2 2 1 Ecdysteroid kinase APH PF01636.18 KOO53609.1 - 4.6e-07 29.8 0.7 1.6e-06 28.0 0.0 2.2 2 1 0 2 2 2 1 Phosphotransferase enzyme family Response_reg PF00072.19 KOO53609.1 - 0.00081 19.3 0.0 0.0024 17.8 0.0 1.8 1 0 0 1 1 1 1 Response regulator receiver domain Choline_kinase PF01633.15 KOO53609.1 - 0.0035 16.9 0.0 0.0079 15.7 0.0 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase TPR_12 PF13424.1 KOO53609.1 - 0.0061 16.4 1.3 1.1 9.2 0.2 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO53609.1 - 0.68 10.7 5.3 4.5 8.1 0.0 4.1 4 1 0 4 4 4 0 Tetratricopeptide repeat RNA_GG_bind PF10258.4 KOO53610.1 - 1e-18 66.7 0.0 1.8e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 PHAX RNA-binding domain zf-CCHC_3 PF13917.1 KOO53610.1 - 1.9e-05 24.2 9.9 0.013 15.1 0.3 2.7 2 1 0 2 2 2 2 Zinc knuckle zf-CCHC_5 PF14787.1 KOO53610.1 - 0.00031 20.1 10.4 0.063 12.7 0.3 3.3 3 0 0 3 3 3 2 GAG-polyprotein viral zinc-finger zf-CCHC_4 PF14392.1 KOO53610.1 - 0.032 13.8 3.3 3.8 7.2 0.2 2.8 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.1 KOO53610.1 - 0.049 13.1 30.4 0.056 12.9 0.4 4.4 2 2 2 4 4 4 0 Zinc knuckle zf-CCHC PF00098.18 KOO53610.1 - 0.053 13.4 7.2 1.4 9.0 0.6 2.6 2 0 0 2 2 2 0 Zinc knuckle DUF2197 PF09963.4 KOO53610.1 - 0.26 11.2 12.9 3 7.8 0.0 4.4 3 1 1 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2197) eIF3g PF12353.3 KOO53610.1 - 7.2 6.5 15.1 5.2 7.0 0.0 3.5 2 1 1 3 3 3 0 Eukaryotic translation initiation factor 3 subunit G PHD PF00628.24 KOO53610.1 - 8.8 6.1 18.8 5.4 6.7 2.9 3.1 2 2 1 3 3 3 0 PHD-finger LRR_6 PF13516.1 KOO53611.1 - 8.1e-20 68.6 0.6 7.8e-05 22.3 0.0 5.0 4 0 0 4 4 4 4 Leucine Rich repeat LRR_4 PF12799.2 KOO53611.1 - 0.054 13.1 0.5 1.7 8.3 0.1 2.7 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) SpoU_sub_bind PF08032.7 KOO53611.1 - 0.074 13.2 0.7 6.5 6.9 0.1 3.2 1 1 2 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding CbiG_N PF11760.3 KOO53611.1 - 0.41 10.3 4.6 4.3 7.0 0.2 3.0 2 1 1 3 3 3 0 Cobalamin synthesis G N-terminal CS PF04969.11 KOO53612.1 - 2.6e-09 37.5 0.0 3.7e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 CS domain Qn_am_d_aIII PF09099.5 KOO53612.1 - 0.058 13.7 0.4 7.4 6.9 0.1 2.4 1 1 1 2 2 2 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain III RBM39linker PF15519.1 KOO53613.1 - 0.1 12.9 0.6 3.2 8.0 0.0 2.5 2 0 0 2 2 2 0 linker between RRM2 and RRM3 domains in RBM39 protein Laminin_G_3 PF13385.1 KOO53614.1 - 1.7e-08 34.8 0.1 3.5e-08 33.8 0.1 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily ART PF01129.13 KOO53615.1 - 3.5e-17 62.2 0.0 4.9e-17 61.7 0.0 1.2 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.9 KOO53615.1 - 1.1e-05 24.6 0.0 1.7e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosyltransferase exoenzyme CCDC-167 PF15188.1 KOO53615.1 - 0.02 14.7 0.0 8.7 6.3 0.0 3.1 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 167 Paf1 PF03985.8 KOO53616.1 - 2.8e-43 148.2 0.0 2.8e-43 148.2 0.0 2.1 2 1 0 2 2 2 1 Paf1 EF-hand_6 PF13405.1 KOO53618.1 - 4.8e-11 41.5 0.5 0.00017 21.1 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 KOO53618.1 - 6.1e-10 37.6 0.3 0.00057 19.0 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO53618.1 - 8.9e-10 38.5 0.4 1.7e-09 37.6 0.3 1.5 1 0 0 1 1 1 1 EF-hand domain pair WW PF00397.21 KOO53618.1 - 1.4e-08 34.4 0.0 3.7e-08 33.0 0.0 1.8 1 0 0 1 1 1 1 WW domain EF-hand_8 PF13833.1 KOO53618.1 - 1.4e-05 24.5 0.2 4.5e-05 22.9 0.1 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.1 KOO53618.1 - 0.01 15.1 0.9 0.69 9.3 0.0 2.8 2 1 0 2 2 2 0 EF hand SPARC_Ca_bdg PF10591.4 KOO53618.1 - 0.049 13.6 0.1 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region PS-DH PF14765.1 KOO53619.1 - 1.6e-18 66.9 0.3 2.1e-18 66.4 0.2 1.2 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.17 KOO53619.1 - 5.4e-18 64.9 2.5 1.1e-17 63.9 1.8 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Exo_endo_phos PF03372.18 KOO53621.1 - 8.1e-18 65.2 0.0 1.2e-17 64.7 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 KOO53621.1 - 0.0064 16.0 0.0 0.015 14.8 0.0 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase 4HB_MCP_1 PF12729.2 KOO53621.1 - 0.04 13.2 0.0 0.094 12.0 0.0 1.5 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction Macoilin PF09726.4 KOO53625.1 - 9.8 4.3 10.6 13 3.9 7.3 1.2 1 0 0 1 1 1 0 Transmembrane protein EF-hand_1 PF00036.27 KOO53626.1 - 2.3e-11 42.1 0.3 2e-05 23.5 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO53626.1 - 1.4e-09 37.9 0.1 3.7e-09 36.5 0.2 1.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 KOO53626.1 - 6.7e-09 34.8 0.2 0.00042 19.9 0.0 3.1 2 1 1 3 3 3 2 EF-hand domain EF-hand_8 PF13833.1 KOO53626.1 - 6.1e-05 22.5 0.8 0.012 15.2 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO53626.1 - 0.00051 19.2 0.4 0.22 10.9 0.0 2.6 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.4 KOO53626.1 - 0.015 15.3 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Glyco_trans_1_4 PF13692.1 KOO53627.1 - 2e-12 47.4 0.6 5e-11 42.8 0.1 2.4 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.15 KOO53627.1 - 0.0047 16.3 0.0 0.0087 15.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 bHLH-MYC_N PF14215.1 KOO53630.1 - 0.12 12.5 0.1 1.2 9.2 0.0 2.0 2 0 0 2 2 2 0 bHLH-MYC and R2R3-MYB transcription factors N-terminal cNMP_binding PF00027.24 KOO53631.1 - 4.1e-45 151.5 0.0 7e-23 80.2 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain PP2C PF00481.16 KOO53631.1 - 9.3e-38 130.0 0.0 1.5e-37 129.3 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C Pkinase PF00069.20 KOO53631.1 - 4.1e-20 72.0 0.0 1.1e-19 70.5 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain PP2C_2 PF13672.1 KOO53631.1 - 9.5e-06 25.1 0.0 0.00015 21.2 0.0 2.2 2 0 0 2 2 2 1 Protein phosphatase 2C Pkinase_Tyr PF07714.12 KOO53631.1 - 1.4e-05 24.3 0.0 2.3e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase LIF_OSM PF01291.12 KOO53633.1 - 0.014 15.3 1.1 0.023 14.6 0.1 1.8 2 0 0 2 2 2 0 LIF / OSM family CALCOCO1 PF07888.6 KOO53633.1 - 0.015 13.5 11.6 0.03 12.6 4.5 2.1 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like TMF_TATA_bd PF12325.3 KOO53633.1 - 0.83 9.4 9.3 1.2 8.8 1.2 4.0 3 2 1 4 4 4 0 TATA element modulatory factor 1 TATA binding Fib_alpha PF08702.5 KOO53633.1 - 4.6 7.3 10.8 13 5.9 2.2 3.2 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Glyco_transf_8 PF01501.15 KOO53634.1 - 0.018 14.3 0.0 0.03 13.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 8 DUF2267 PF10025.4 KOO53635.1 - 4.4 7.3 16.1 0.024 14.6 1.9 3.1 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2267) DNA_gyraseB PF00204.20 KOO53636.1 - 0.91 8.7 7.1 1.2 8.3 4.4 1.5 1 1 0 1 1 1 0 DNA gyrase B KxDL PF10241.4 KOO53636.1 - 1.2 9.1 4.5 0.52 10.2 0.5 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein DUF4449 PF14613.1 KOO53636.1 - 2.1 8.2 11.9 3.6 7.5 8.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4449) oligo_HPY PF08352.7 KOO53638.1 - 0.13 12.6 0.1 0.34 11.2 0.1 1.8 1 1 0 1 1 1 0 Oligopeptide/dipeptide transporter, C-terminal region RabGAP-TBC PF00566.13 KOO53640.1 - 2.2e-26 92.6 0.0 3e-26 92.2 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Ion_trans PF00520.26 KOO53642.1 - 2.7e-07 30.0 17.2 9.4e-07 28.2 11.9 1.8 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.7 KOO53642.1 - 9.2e-07 27.6 8.3 1.4e-06 27.0 5.7 1.2 1 0 0 1 1 1 1 Polycystin cation channel PWI PF01480.12 KOO53643.1 - 4.7e-10 39.4 0.0 6.7e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 PWI domain DUF3046 PF11248.3 KOO53643.1 - 0.026 14.5 0.0 0.053 13.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3046) DSPc PF00782.15 KOO53644.1 - 4.3e-20 71.6 0.0 6.6e-20 71.0 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DUF563 PF04577.9 KOO53644.1 - 6.4e-09 36.0 0.0 1.1e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Y_phosphatase PF00102.22 KOO53644.1 - 0.041 13.2 0.0 0.067 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Gelsolin PF00626.17 KOO53644.1 - 0.19 11.4 0.0 0.41 10.3 0.0 1.6 1 0 0 1 1 1 0 Gelsolin repeat gag_pre-integrs PF13976.1 KOO53645.1 - 1.5e-07 30.9 0.0 2.4e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 GAG-pre-integrase domain rve PF00665.21 KOO53645.1 - 0.001 19.1 0.1 0.0039 17.2 0.0 1.9 1 1 1 2 2 2 1 Integrase core domain TGFb_propeptide PF00688.13 KOO53646.1 - 0.0021 17.3 0.3 1.7 7.8 0.0 3.1 3 1 0 3 3 3 2 TGF-beta propeptide TGFb_propeptide PF00688.13 KOO53647.1 - 0.0003 20.1 5.6 0.12 11.6 0.1 4.2 5 0 0 5 5 5 3 TGF-beta propeptide HTH_Tnp_ISL3 PF13542.1 KOO53648.1 - 0.01 14.9 1.6 9.5 5.4 0.2 3.3 3 0 0 3 3 3 0 Helix-turn-helix domain of transposase family ISL3 MCH PF02289.11 KOO53650.1 - 0.12 11.3 0.0 0.14 11.2 0.0 1.0 1 0 0 1 1 1 0 Cyclohydrolase (MCH) Thioredoxin_8 PF13905.1 KOO53652.1 - 1.7e-21 76.1 0.0 3.5e-21 75.1 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 KOO53652.1 - 5.5e-08 32.9 0.0 1e-07 32.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin PF00085.15 KOO53652.1 - 8e-06 25.4 0.0 0.00072 19.2 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin AhpC-TSA PF00578.16 KOO53652.1 - 0.015 14.9 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_7 PF13899.1 KOO53652.1 - 0.024 14.6 0.0 0.057 13.4 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin-like EF-hand_1 PF00036.27 KOO53653.1 - 1.9e-25 86.2 1.1 1.1e-06 27.4 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 KOO53653.1 - 5.8e-22 75.5 2.5 0.00015 21.3 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 KOO53653.1 - 3.9e-20 71.7 0.1 1.4e-10 41.1 0.0 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO53653.1 - 6.9e-20 69.4 6.9 0.00021 20.5 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.1 KOO53653.1 - 2.1e-16 59.2 2.3 0.0047 16.5 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_10 PF14788.1 KOO53653.1 - 2e-05 24.1 0.4 2.1 8.0 0.0 4.0 4 0 0 4 4 4 2 EF hand EF-hand_4 PF12763.2 KOO53653.1 - 0.052 13.2 0.1 26 4.6 0.0 3.3 3 0 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 KOO53653.1 - 0.12 12.4 0.5 32 4.5 0.0 3.4 3 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region ACC_epsilon PF13822.1 KOO53653.1 - 1.4 9.2 6.1 0.72 10.2 0.5 2.5 2 0 0 2 2 2 0 Acyl-CoA carboxylase epsilon subunit EF-hand_7 PF13499.1 KOO53654.1 - 2.2e-37 126.9 2.6 1.2e-07 31.7 0.0 5.3 4 1 1 5 5 5 5 EF-hand domain pair EF-hand_1 PF00036.27 KOO53654.1 - 5.8e-35 115.9 15.1 4.6e-05 22.4 0.0 8.3 7 1 1 8 8 8 7 EF hand EF-hand_6 PF13405.1 KOO53654.1 - 4.1e-33 110.2 18.2 3e-05 23.5 0.0 8.5 5 3 3 8 8 8 7 EF-hand domain EF-hand_5 PF13202.1 KOO53654.1 - 3.9e-29 98.6 20.3 5.1e-05 22.4 0.0 8.2 8 0 0 8 8 8 7 EF hand EF-hand_8 PF13833.1 KOO53654.1 - 6.5e-25 86.4 11.9 1.2e-07 31.2 0.0 6.0 5 1 1 6 6 6 6 EF-hand domain pair EF-hand_9 PF14658.1 KOO53654.1 - 2.2e-06 27.4 0.1 0.15 11.9 0.0 4.2 4 0 0 4 4 4 2 EF-hand domain Lip_prot_lig_C PF10437.4 KOO53654.1 - 9.6e-05 21.9 0.2 0.44 10.2 0.0 4.1 4 0 0 4 4 4 1 Bacterial lipoate protein ligase C-terminus SPARC_Ca_bdg PF10591.4 KOO53654.1 - 0.00087 19.3 0.0 4.3 7.4 0.0 3.6 3 0 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 KOO53654.1 - 0.0014 18.2 0.7 1.9 8.2 0.0 4.5 5 1 1 6 6 6 1 EF hand SAP PF02037.22 KOO53654.1 - 0.0058 16.1 0.3 2 8.0 0.0 3.1 2 0 0 2 2 2 1 SAP domain EF-hand_4 PF12763.2 KOO53654.1 - 0.008 15.8 3.2 11 5.8 0.1 4.8 2 2 3 5 5 5 0 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.8 KOO53654.1 - 0.078 12.5 0.0 29 4.1 0.0 3.4 5 0 0 5 5 5 0 Caleosin related protein DUF4031 PF13223.1 KOO53654.1 - 0.092 12.9 0.1 44 4.3 0.0 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF4031) HALZ PF02183.13 KOO53654.1 - 0.13 12.0 0.7 0.42 10.3 0.5 1.8 1 0 0 1 1 1 0 Homeobox associated leucine zipper Abhydrolase_6 PF12697.2 KOO53655.1 - 0.00016 21.6 0.0 0.00023 21.1 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 KOO53655.1 - 0.00024 20.8 0.0 0.00034 20.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.5 KOO53655.1 - 0.008 16.0 0.0 0.0085 15.9 0.0 1.2 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_2 PF02230.11 KOO53655.1 - 0.071 12.5 0.0 0.077 12.4 0.0 1.1 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase LpxD PF04613.9 KOO53655.1 - 0.085 12.4 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD Glyco_hydro_47 PF01532.15 KOO53656.1 - 3.4e-43 147.9 0.1 4.2e-43 147.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Mito_carr PF00153.22 KOO53657.1 - 3.2e-45 151.7 9.7 1.1e-16 60.2 0.1 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein WD40 PF00400.27 KOO53659.1 - 3.3e-57 188.4 20.8 2.2e-09 36.8 0.2 9.2 10 0 0 10 10 10 8 WD domain, G-beta repeat Utp13 PF08625.6 KOO53659.1 - 0.0003 20.4 0.1 0.00056 19.5 0.1 1.4 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain Nup160 PF11715.3 KOO53659.1 - 0.00051 18.3 8.4 0.089 10.9 0.9 4.7 2 2 1 3 3 3 3 Nucleoporin Nup120/160 DUF3593 PF12159.3 KOO53660.1 - 1.4e-23 82.5 0.2 2.5e-23 81.6 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3593) DUF2499 PF10693.4 KOO53660.1 - 4.4e-16 58.6 0.1 1.3e-15 57.1 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2499) CbtB PF09489.5 KOO53660.1 - 2.4 8.1 6.1 0.63 9.9 1.0 2.5 2 1 0 2 2 2 0 Probable cobalt transporter subunit (CbtB) TPR_11 PF13414.1 KOO53661.1 - 2.3e-21 75.2 14.4 2.7e-09 36.5 0.3 4.3 4 1 0 5 5 5 3 TPR repeat TPR_2 PF07719.12 KOO53661.1 - 1.1e-13 49.9 15.6 0.00015 21.4 0.0 6.8 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO53661.1 - 5.3e-12 44.8 3.4 0.00043 19.7 0.0 5.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO53661.1 - 7.2e-06 26.5 20.1 0.00033 21.2 0.1 5.5 4 1 2 6 6 5 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO53661.1 - 7.9e-06 25.7 10.1 0.00072 19.4 1.2 4.3 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 KOO53661.1 - 2.8e-05 23.9 3.5 0.69 10.2 0.0 4.8 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 KOO53661.1 - 0.00024 21.4 23.4 0.012 16.1 0.3 5.7 4 1 2 6 6 6 3 Tetratricopeptide repeat DUF2530 PF10745.4 KOO53661.1 - 0.00052 19.9 0.0 1.8 8.6 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF2530) TPR_8 PF13181.1 KOO53661.1 - 0.00095 18.7 0.6 0.48 10.3 0.0 4.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO53661.1 - 0.0012 19.1 9.1 0.0057 16.9 0.1 4.5 4 1 1 5 5 5 2 Tetratricopeptide repeat Coatomer_E PF04733.9 KOO53661.1 - 0.0046 16.1 0.3 0.69 9.0 0.0 3.0 2 1 1 3 3 3 1 Coatomer epsilon subunit TPR_9 PF13371.1 KOO53661.1 - 0.011 15.6 8.9 0.15 11.9 0.8 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat Lambda_Kil PF06301.6 KOO53661.1 - 0.065 12.6 1.7 7.6 6.0 0.1 2.5 2 0 0 2 2 2 0 Bacteriophage lambda Kil protein TPR_6 PF13174.1 KOO53661.1 - 0.071 13.5 3.1 47 4.7 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Apc3 PF12895.2 KOO53661.1 - 1.6 8.8 6.4 3.2 7.9 0.0 3.3 2 1 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 EF-hand_7 PF13499.1 KOO53663.1 - 1.2e-06 28.5 0.0 2.9e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 KOO53663.1 - 3.4e-06 25.9 0.2 0.0043 16.2 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO53663.1 - 4.5e-06 26.1 0.7 0.00061 19.4 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.1 KOO53663.1 - 2.7e-05 23.6 0.5 0.012 15.1 0.0 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 KOO53663.1 - 0.025 13.8 6.8 0.058 12.7 0.0 3.0 3 0 0 3 3 3 0 EF hand 14-3-3 PF00244.15 KOO53664.1 - 5.3e-102 339.9 2.1 5.8e-102 339.7 1.4 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.1 KOO53664.1 - 0.09 12.7 5.3 1.1 9.3 0.3 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat Pectate_lyase_3 PF12708.2 KOO53665.1 - 0.038 14.1 0.3 0.05 13.7 0.2 1.2 1 0 0 1 1 1 0 Pectate lyase superfamily protein PE PF00934.15 KOO53666.1 - 1.9 8.6 7.9 0.12 12.4 1.2 2.2 3 0 0 3 3 3 0 PE family WD40 PF00400.27 KOO53667.1 - 1.1e-55 183.6 10.5 4e-11 42.3 0.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Nucleoporin_N PF08801.6 KOO53667.1 - 0.00013 20.8 0.0 0.22 10.1 0.0 3.3 2 1 1 3 3 3 3 Nup133 N terminal like Nup160 PF11715.3 KOO53667.1 - 0.24 9.4 4.9 2.8 5.9 0.1 3.6 1 1 2 3 3 3 0 Nucleoporin Nup120/160 CDC37_C PF08564.5 KOO53668.1 - 0.014 15.2 0.1 0.021 14.6 0.1 1.3 1 0 0 1 1 1 0 Cdc37 C terminal domain Peptidase_C1 PF00112.18 KOO53669.1 - 1.1e-54 185.6 9.4 1.4e-54 185.2 6.5 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.7 KOO53669.1 - 1.3e-09 38.2 0.0 2.1e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.10 KOO53669.1 - 2.9e-05 22.7 1.2 0.078 11.4 0.0 2.2 2 0 0 2 2 2 2 Peptidase C1-like family HCaRG PF07258.9 KOO53671.1 - 2.1e-12 46.9 0.2 4.7e-12 45.8 0.1 1.6 2 0 0 2 2 2 1 HCaRG protein DnaJ PF00226.26 KOO53671.1 - 6.8e-12 44.9 0.0 1.6e-11 43.7 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain Zip PF02535.17 KOO53672.1 - 1.7e-20 73.3 15.0 5.9e-18 64.9 6.1 2.2 2 0 0 2 2 2 2 ZIP Zinc transporter DAO PF01266.19 KOO53673.1 - 5.7e-36 124.1 1.6 7.2e-36 123.8 1.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase TPR_11 PF13414.1 KOO53674.1 - 6.3e-06 25.7 9.8 1e-05 25.0 2.6 2.7 3 0 0 3 3 3 1 TPR repeat TPR_2 PF07719.12 KOO53674.1 - 0.0016 18.2 10.2 0.028 14.3 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 KOO53674.1 - 0.0044 16.7 0.5 6.4 6.8 0.0 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 KOO53674.1 - 0.047 13.4 6.7 0.43 10.5 0.2 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.1 KOO53674.1 - 0.048 13.9 14.6 0.21 11.9 4.9 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.1 KOO53674.1 - 0.051 13.7 0.4 0.39 11.0 0.1 2.6 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 KOO53674.1 - 0.083 12.5 2.7 0.7 9.5 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 KOO53674.1 - 0.18 11.7 13.2 3.7 7.5 0.4 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 KOO53674.1 - 0.3 11.8 26.9 0.52 11.1 3.4 5.2 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.1 KOO53674.1 - 1.8 9.3 21.8 0.12 13.0 8.4 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_20 PF14561.1 KOO53674.1 - 7 6.8 12.0 0.47 10.6 4.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Arm PF00514.18 KOO53675.1 - 2.8e-10 39.6 13.9 0.0027 17.4 0.1 5.9 6 1 0 6 6 6 4 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.1 KOO53675.1 - 1.7 9.2 11.9 30 5.2 0.2 5.0 4 1 0 4 4 4 0 HEAT-like repeat Ifi-6-16 PF06140.8 KOO53675.1 - 2.3 8.0 7.9 0.72 9.6 0.4 2.6 1 1 1 2 2 2 0 Interferon-induced 6-16 family Arm PF00514.18 KOO53676.1 - 7e-23 79.6 17.3 4.4e-06 26.2 0.1 5.7 5 1 0 5 5 5 5 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 KOO53676.1 - 0.001 19.2 18.5 0.0018 18.5 2.0 3.8 1 1 3 4 4 4 3 HEAT repeats Arm_2 PF04826.8 KOO53676.1 - 0.0063 15.6 0.0 0.19 10.7 0.0 2.4 2 1 1 3 3 3 2 Armadillo-like DUF2526 PF10735.4 KOO53676.1 - 0.13 12.2 1.9 8.9 6.3 0.1 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2526) EST1_DNA_bind PF10373.4 KOO53677.1 - 0.0095 15.1 0.1 0.014 14.6 0.0 1.2 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain TPR_11 PF13414.1 KOO53678.1 - 9.3e-14 50.8 0.1 7.9e-08 31.8 0.0 3.4 1 1 2 3 3 3 2 TPR repeat TPR_17 PF13431.1 KOO53678.1 - 3.3e-11 42.4 0.0 0.068 13.4 0.0 4.9 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO53678.1 - 1.4e-08 33.9 0.4 0.099 12.2 0.0 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.1 KOO53678.1 - 8.3e-08 31.4 0.0 0.032 14.0 0.0 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.12 KOO53678.1 - 3e-07 29.8 3.4 0.021 14.7 0.0 4.8 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.1 KOO53678.1 - 9.2e-06 25.8 11.4 0.031 14.9 0.0 4.9 3 2 3 6 6 6 2 Tetratricopeptide repeat ShK PF01549.19 KOO53678.1 - 1.4e-05 25.3 10.0 1.4e-05 25.3 7.0 1.9 2 0 0 2 2 2 1 ShK domain-like TPR_16 PF13432.1 KOO53678.1 - 1.6e-05 25.4 8.9 0.31 11.7 0.0 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 KOO53678.1 - 0.00036 20.4 3.5 0.018 14.9 0.0 3.5 2 2 2 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.1 KOO53678.1 - 0.0037 17.5 7.0 0.35 11.2 0.2 4.4 3 2 3 6 6 6 2 Tetratricopeptide repeat TPR_20 PF14561.1 KOO53678.1 - 0.034 14.2 1.3 4.2 7.5 0.1 3.2 3 1 1 4 4 3 0 Tetratricopeptide repeat TIL PF01826.12 KOO53678.1 - 7.3 6.7 13.4 1.9 8.7 0.8 2.4 2 0 0 2 2 2 0 Trypsin Inhibitor like cysteine rich domain Glyco_transf_10 PF00852.14 KOO53681.1 - 4.9e-19 68.1 0.0 9.7e-19 67.1 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) TilS PF09179.6 KOO53681.1 - 0.082 12.9 0.0 0.25 11.3 0.0 1.8 1 0 0 1 1 1 0 TilS substrate binding domain Rnk_N PF14760.1 KOO53683.1 - 4 7.5 16.5 1.5 8.9 1.0 4.7 4 0 0 4 4 4 0 Rnk N-terminus Pkinase PF00069.20 KOO53684.1 - 6.5e-48 163.1 0.0 8.9e-48 162.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO53684.1 - 8.6e-39 133.1 0.0 1.5e-38 132.3 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO53684.1 - 6.5e-05 22.0 0.0 9.7e-05 21.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 KOO53684.1 - 0.0056 16.4 0.2 0.063 12.9 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 KOO53684.1 - 0.12 11.3 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ETAA1 PF15350.1 KOO53684.1 - 0.28 9.1 7.5 0.71 7.8 0.2 2.8 2 1 1 3 3 3 0 Ewing's tumour-associated antigen 1 homologue WD40 PF00400.27 KOO53685.1 - 1.4e-13 50.0 2.3 0.00089 19.0 0.0 5.3 5 0 0 5 5 5 3 WD domain, G-beta repeat Exotox-A_bind PF09101.5 KOO53685.1 - 0.13 11.3 0.0 12 4.9 0.0 2.4 2 0 0 2 2 2 0 Exotoxin A binding zf-RING_2 PF13639.1 KOO53686.1 - 7.3e-10 38.5 8.2 7.3e-10 38.5 5.7 2.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 KOO53686.1 - 4.7e-06 26.2 6.1 4.7e-06 26.2 4.3 2.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.20 KOO53686.1 - 5.4e-06 25.9 6.2 5.4e-06 25.9 4.3 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 KOO53686.1 - 0.00017 21.5 7.5 0.00017 21.5 5.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_Tnp_IS91 PF14319.1 KOO53686.1 - 0.005 16.3 2.6 0.005 16.3 1.8 1.9 2 0 0 2 2 2 1 Transposase zinc-binding domain zf-Apc11 PF12861.2 KOO53686.1 - 0.12 12.2 4.4 0.4 10.5 3.1 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 KOO53686.1 - 0.13 11.9 4.5 0.27 11.0 1.8 2.3 1 1 1 2 2 2 0 RING-type zinc-finger CK_II_beta PF01214.13 KOO53687.1 - 5e-74 247.7 0.1 7.1e-74 247.2 0.1 1.2 1 0 0 1 1 1 1 Casein kinase II regulatory subunit tRNA_edit PF04073.10 KOO53687.1 - 1e-05 25.3 0.0 1.9e-05 24.5 0.0 1.5 1 1 0 1 1 1 1 Aminoacyl-tRNA editing domain DTW PF03942.10 KOO53689.1 - 1.9e-13 50.0 0.0 3e-13 49.4 0.0 1.3 1 1 0 1 1 1 1 DTW domain WD40 PF00400.27 KOO53690.1 - 1.8e-10 40.2 7.6 2.7e-09 36.5 0.1 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat Pkinase PF00069.20 KOO53690.1 - 0.21 10.7 0.0 28 3.7 0.0 2.9 2 1 0 2 2 2 0 Protein kinase domain RVT_2 PF07727.9 KOO53691.1 - 2.6e-39 134.6 0.0 4.1e-39 134.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Antibiotic_NAT PF02522.9 KOO53691.1 - 0.083 12.1 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 Aminoglycoside 3-N-acetyltransferase Tricorn_C1 PF14684.1 KOO53692.1 - 1.7e-14 53.4 0.0 2.9e-14 52.6 0.0 1.4 1 0 0 1 1 1 1 Tricorn protease C1 domain Peptidase_S41 PF03572.13 KOO53692.1 - 4e-13 49.1 0.0 6.3e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S41 Tricorn_PDZ PF14685.1 KOO53692.1 - 0.00018 21.1 0.0 0.00042 20.0 0.0 1.6 1 0 0 1 1 1 1 Tricorn protease PDZ domain PAN_4 PF14295.1 KOO53693.1 - 0.00019 21.0 10.5 0.091 12.4 0.4 3.3 2 1 0 2 2 2 2 PAN domain DEK_C PF08766.6 KOO53694.1 - 9.2e-08 31.7 0.4 1.3e-07 31.3 0.3 1.2 1 0 0 1 1 1 1 DEK C terminal domain Glyco_hydro_47 PF01532.15 KOO53696.1 - 2.8e-83 280.1 0.0 3.4e-83 279.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 RNA_pol_3_Rpc31 PF11705.3 KOO53697.1 - 2.4 8.0 19.9 14 5.5 13.8 2.2 1 1 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 LRR_6 PF13516.1 KOO53698.1 - 4.6e-68 217.6 10.9 1.3e-05 24.7 0.0 13.3 13 0 0 13 13 13 12 Leucine Rich repeat LRR_1 PF00560.28 KOO53698.1 - 2e-12 45.3 0.0 18 5.8 0.0 9.9 11 0 0 11 11 10 0 Leucine Rich Repeat LRR_4 PF12799.2 KOO53698.1 - 9.1e-12 44.3 8.8 0.71 9.5 0.0 8.7 4 2 4 8 8 8 4 Leucine Rich repeats (2 copies) LRR_7 PF13504.1 KOO53698.1 - 1.2e-06 27.7 15.3 44 4.9 0.0 10.5 13 0 0 13 13 10 0 Leucine rich repeat LRR_8 PF13855.1 KOO53698.1 - 1.2e-06 28.1 8.4 0.38 10.5 0.1 6.9 4 3 3 7 7 7 2 Leucine rich repeat DUF4396 PF14342.1 KOO53698.1 - 0.00091 19.3 1.9 15 5.6 0.1 3.7 2 1 0 3 3 3 0 Domain of unknown function (DUF4396) YycC PF14174.1 KOO53698.1 - 0.0033 17.0 0.1 1.1e+02 2.5 0.0 6.7 9 0 0 9 9 9 0 YycC-like protein SpoU_sub_bind PF08032.7 KOO53698.1 - 0.005 16.9 10.2 3.5 7.8 0.0 6.3 6 1 1 7 7 7 1 RNA 2'-O ribose methyltransferase substrate binding YusW PF14039.1 KOO53698.1 - 0.013 15.7 3.4 23 5.3 0.0 5.1 1 1 4 7 7 7 0 YusW-like protein DUF3168 PF11367.3 KOO53698.1 - 0.21 11.7 2.2 8.3 6.5 0.0 4.1 3 1 1 4 4 4 0 Protein of unknown function (DUF3168) HTH_19 PF12844.2 KOO53698.1 - 0.47 10.5 2.1 25 5.0 0.0 4.6 6 1 1 7 7 7 0 Helix-turn-helix domain DUF2202 PF09968.4 KOO53698.1 - 0.97 9.0 10.6 39 3.8 0.0 6.1 2 2 5 8 8 8 0 Uncharacterized protein domain (DUF2202) HTH_3 PF01381.17 KOO53698.1 - 3.2 7.6 9.7 4.7 7.1 0.1 5.5 8 0 0 8 8 8 0 Helix-turn-helix Pkinase PF00069.20 KOO53699.1 - 2.6e-52 177.5 0.0 4.4e-52 176.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO53699.1 - 2e-17 63.1 0.0 3.1e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO53699.1 - 3.4e-07 29.5 0.2 0.00076 18.5 0.0 2.8 1 1 0 2 2 2 2 Kinase-like APH PF01636.18 KOO53699.1 - 2.2e-05 24.3 14.3 7.1e-05 22.6 0.0 4.0 3 1 1 4 4 4 2 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.4 KOO53699.1 - 0.00017 21.0 0.0 0.00017 21.0 0.0 2.2 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL Choline_kinase PF01633.15 KOO53699.1 - 0.0037 16.8 0.0 0.0066 16.0 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Spore_coat_CotO PF14153.1 KOO53699.1 - 0.1 11.9 4.4 0.17 11.3 3.1 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Ycf1 PF05758.7 KOO53699.1 - 0.29 8.8 1.4 0.35 8.5 0.9 1.0 1 0 0 1 1 1 0 Ycf1 CRC_subunit PF08624.5 KOO53701.1 - 0.098 12.5 0.0 0.83 9.5 0.0 2.2 2 0 0 2 2 2 0 Chromatin remodelling complex Rsc7/Swp82 subunit Sigma70_r2 PF04542.9 KOO53702.1 - 1.3e-19 69.5 0.1 2.9e-19 68.4 0.1 1.6 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r3 PF04539.11 KOO53702.1 - 1.4e-18 66.5 2.3 9.2e-10 38.2 0.0 2.4 2 0 0 2 2 2 2 Sigma-70 region 3 Sigma70_r1_2 PF00140.15 KOO53702.1 - 6.8e-08 32.0 0.1 1.4e-07 31.0 0.1 1.5 1 0 0 1 1 1 1 Sigma-70 factor, region 1.2 DUF742 PF05331.6 KOO53702.1 - 0.028 13.9 0.1 1.3 8.6 0.0 2.9 2 1 0 3 3 3 0 Protein of unknown function (DUF742) DUF3071 PF11268.3 KOO53702.1 - 0.031 14.0 0.8 0.055 13.1 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) Ank_2 PF12796.2 KOO53703.1 - 6.1e-06 26.4 0.0 1.4e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO53703.1 - 0.00014 21.4 0.5 0.0025 17.5 0.1 2.7 2 1 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.1 KOO53703.1 - 0.00014 21.9 0.4 0.00072 19.7 0.1 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO53703.1 - 0.0017 18.8 0.1 0.003 18.0 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO53703.1 - 0.0051 16.9 0.1 0.19 12.0 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat 2OG-FeII_Oxy_3 PF13640.1 KOO53703.1 - 0.0072 16.8 0.0 0.021 15.3 0.0 1.8 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF106 PF01956.11 KOO53704.1 - 1.1e-22 80.3 0.2 2.5e-22 79.1 0.0 1.6 2 0 0 2 2 2 1 Integral membrane protein DUF106 SseB_C PF14581.1 KOO53704.1 - 0.061 13.1 0.3 2.3 8.0 0.0 2.4 2 0 0 2 2 2 0 SseB protein C-terminal domain DSHCT PF08148.7 KOO53705.1 - 2e-13 49.9 0.0 5.7e-13 48.5 0.0 1.8 1 1 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.24 KOO53705.1 - 8.1e-10 38.4 0.1 1.8e-09 37.3 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO53705.1 - 3.5e-06 26.7 0.0 1.2e-05 25.1 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO53705.1 - 0.0014 18.4 0.1 0.0023 17.7 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 KOO53705.1 - 0.0095 15.6 1.0 0.038 13.7 0.1 2.6 2 0 0 2 2 2 1 Part of AAA domain THOC7 PF05615.8 KOO53706.1 - 0.0079 16.4 2.8 0.015 15.5 1.9 1.5 1 0 0 1 1 1 1 Tho complex subunit 7 MORN PF02493.15 KOO53706.1 - 0.051 13.3 4.0 0.97 9.2 0.6 2.4 2 0 0 2 2 2 0 MORN repeat Pyr_redox_3 PF13738.1 KOO53708.1 - 0.0068 16.4 0.0 0.029 14.4 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GILT PF03227.11 KOO53709.1 - 0.036 13.9 0.5 0.079 12.8 0.4 1.6 1 0 0 1 1 1 0 Gamma interferon inducible lysosomal thiol reductase (GILT) DHC_N1 PF08385.7 KOO53710.1 - 1.2e-129 433.3 0.1 9e-129 430.4 0.0 2.4 2 1 1 3 3 3 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.2 KOO53710.1 - 2e-106 354.7 0.0 1.1e-105 352.2 0.0 2.2 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region D1 DHC_N2 PF08393.8 KOO53710.1 - 2.2e-102 342.6 4.4 2.4e-102 342.4 0.4 3.0 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.2 KOO53710.1 - 8e-75 251.2 0.1 3.5e-74 249.1 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_7 PF12775.2 KOO53710.1 - 2.9e-70 236.4 0.2 5.7e-70 235.5 0.1 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D3 AAA_5 PF07728.9 KOO53710.1 - 3.5e-16 59.1 0.0 1.4e-06 28.0 0.0 5.4 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA PF00004.24 KOO53710.1 - 0.0005 20.2 0.1 3.9 7.6 0.0 3.9 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 KOO53710.1 - 0.022 14.8 0.0 9.1 6.4 0.0 3.5 3 0 0 3 3 3 0 AAA domain Phage_lysis PF03245.8 KOO53710.1 - 0.15 12.0 0.0 9.8 6.1 0.0 2.7 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein Sec1 PF00995.18 KOO53711.1 - 8.5e-150 500.0 0.3 9.7e-150 499.8 0.2 1.0 1 0 0 1 1 1 1 Sec1 family Kinesin-related PF06548.6 KOO53711.1 - 0.058 11.9 0.4 0.094 11.2 0.3 1.3 1 0 0 1 1 1 0 Kinesin-related Peptidase_C2 PF00648.16 KOO53712.1 - 7e-40 136.8 0.1 1.2e-39 136.1 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease MDH PF02315.11 KOO53713.1 - 0.37 10.7 1.5 1.6 8.7 0.2 2.2 2 1 0 2 2 2 0 Methanol dehydrogenase beta subunit SET PF00856.23 KOO53715.1 - 0.0011 19.2 0.1 0.0026 18.0 0.1 1.8 1 1 0 1 1 1 1 SET domain TPR_12 PF13424.1 KOO53715.1 - 1.5 8.8 8.3 0.56 10.1 2.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat NAAA-beta PF15508.1 KOO53716.1 - 8e-08 32.5 0.0 1.4e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase FAD_binding_4 PF01565.18 KOO53717.1 - 1.1e-11 44.3 0.1 1.8e-11 43.6 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain PPR_2 PF13041.1 KOO53718.1 - 2.2e-42 142.8 0.0 6.1e-10 38.9 0.0 7.4 4 2 2 7 7 7 6 PPR repeat family PPR_3 PF13812.1 KOO53718.1 - 9.8e-42 137.7 23.2 2.5e-05 24.2 0.0 10.9 11 0 0 11 11 11 9 Pentatricopeptide repeat domain PPR PF01535.15 KOO53718.1 - 9.1e-30 100.5 0.0 4.7e-05 23.0 0.0 9.2 10 0 0 10 10 10 6 PPR repeat PPR_1 PF12854.2 KOO53718.1 - 6.2e-27 92.7 0.0 0.00011 21.6 0.0 8.1 8 0 0 8 8 8 7 PPR repeat TPR_16 PF13432.1 KOO53718.1 - 0.039 14.6 33.0 0.89 10.3 5.2 6.1 5 1 1 6 6 6 0 Tetratricopeptide repeat B12-binding_2 PF02607.12 KOO53718.1 - 0.05 13.6 1.6 9.7 6.2 0.0 4.4 4 1 1 5 5 5 0 B12 binding domain TPR_14 PF13428.1 KOO53718.1 - 0.63 10.8 41.3 9.3 7.2 0.1 9.4 5 3 5 10 10 10 0 Tetratricopeptide repeat MORN PF02493.15 KOO53719.1 - 0.1 12.3 0.2 2.8 7.8 0.0 2.9 3 0 0 3 3 3 0 MORN repeat PROL5-SMR PF15621.1 KOO53719.1 - 0.12 12.8 1.0 0.19 12.1 0.7 1.3 1 0 0 1 1 1 0 Proline-rich submaxillary gland androgen-regulated family ADK PF00406.17 KOO53720.1 - 3.2e-20 72.5 0.0 4.7e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase Cohesin_HEAT PF12765.2 KOO53720.1 - 0.09 12.7 0.2 0.71 9.9 0.2 2.3 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion LRR_5 PF13306.1 KOO53723.1 - 1.5e-91 302.7 0.0 1.3e-34 118.6 0.0 3.0 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO53723.1 - 5.3e-29 99.7 0.0 4.3e-05 23.1 0.0 6.3 1 1 8 9 9 9 9 Leucine rich repeat Fork_head_N PF08430.7 KOO53723.1 - 2.6 8.4 17.5 53 4.2 5.6 3.3 1 1 1 2 2 2 0 Forkhead N-terminal region Erythro_esteras PF05139.9 KOO53724.1 - 1.5e-85 287.4 3.0 1.1e-57 195.8 0.0 3.1 3 0 0 3 3 3 3 Erythromycin esterase FAD_oxidored PF12831.2 KOO53725.1 - 1.9e-73 247.9 0.2 2.2e-73 247.7 0.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 KOO53725.1 - 0.0059 15.4 0.1 0.0059 15.4 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain HCaRG PF07258.9 KOO53726.1 - 4.1e-08 32.9 0.0 5.1e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 HCaRG protein DUF2937 PF11157.3 KOO53727.1 - 0.062 12.6 1.1 11 5.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) GLTP PF08718.6 KOO53728.1 - 5.8e-24 84.8 0.0 7.8e-24 84.4 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) PWWP PF00855.12 KOO53729.1 - 7.2e-10 38.9 0.1 1.5e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 PWWP domain DUF1104 PF06518.6 KOO53730.1 - 0.027 14.6 0.0 0.031 14.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1104) Kelch_4 PF13418.1 KOO53733.1 - 8.4e-29 99.0 8.8 3.7e-06 26.6 0.0 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.1 KOO53733.1 - 2.7e-28 97.4 1.7 2.9e-05 24.0 0.1 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.1 KOO53733.1 - 3e-28 97.2 0.8 1.7e-05 24.6 0.0 5.9 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.1 KOO53733.1 - 2.5e-12 46.3 0.2 8.7e-05 22.5 0.0 5.0 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.10 KOO53733.1 - 1.1e-11 44.0 4.2 0.027 14.2 0.0 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_1 PF01344.20 KOO53733.1 - 3.7e-05 23.1 0.6 0.55 9.8 0.0 4.2 5 0 0 5 5 5 2 Kelch motif RAG2 PF03089.9 KOO53733.1 - 0.0029 16.3 0.0 1.5 7.5 0.0 3.0 4 0 0 4 4 4 2 Recombination activating protein 2 CRAL_TRIO PF00650.15 KOO53734.1 - 3.1e-24 85.2 0.0 4.8e-24 84.6 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain DUF303 PF03629.13 KOO53735.1 - 0.087 12.0 0.0 0.099 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF303) Tau95 PF09734.4 KOO53736.1 - 5e-45 154.1 0.0 7.1e-45 153.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit ResIII PF04851.10 KOO53737.1 - 2.2e-22 79.8 0.0 3.1e-22 79.2 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 KOO53737.1 - 6.7e-13 48.4 0.0 8e-13 48.2 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase Flavi_DEAD PF07652.9 KOO53737.1 - 0.0019 17.9 0.0 0.0026 17.5 0.0 1.2 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_19 PF13245.1 KOO53737.1 - 0.014 15.0 0.2 0.038 13.7 0.2 1.8 1 0 0 1 1 1 0 Part of AAA domain AAA_30 PF13604.1 KOO53737.1 - 0.032 13.8 0.1 0.051 13.1 0.1 1.3 1 0 0 1 1 1 0 AAA domain P-II PF00543.17 KOO53737.1 - 0.16 12.4 0.0 0.28 11.6 0.0 1.3 1 0 0 1 1 1 0 Nitrogen regulatory protein P-II Mpv17_PMP22 PF04117.7 KOO53738.1 - 5.9e-10 38.6 0.3 1.6e-09 37.2 0.0 1.8 1 1 1 2 2 2 1 Mpv17 / PMP22 family BRE1 PF08647.6 KOO53738.1 - 0.14 12.1 1.2 0.22 11.4 0.8 1.2 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase MORN PF02493.15 KOO53739.1 - 1.8e-46 153.1 39.9 7.4e-08 31.6 0.3 9.9 9 1 1 10 10 10 9 MORN repeat TFIIIC_sub6 PF10419.4 KOO53739.1 - 0.18 11.2 13.0 21 4.6 0.1 5.9 6 0 0 6 6 6 0 TFIIIC subunit SBBP PF06739.6 KOO53740.1 - 2.1e-11 43.4 38.8 0.00018 21.2 0.5 6.9 6 0 0 6 6 6 6 Beta-propeller repeat DUF2883 PF11097.3 KOO53740.1 - 0.021 14.9 0.1 86 3.3 0.0 4.4 5 0 0 5 5 5 0 Protein of unknown function (DUF2883) DUF4567 PF15131.1 KOO53740.1 - 0.42 10.7 3.0 11 6.2 0.1 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4567) Fzo_mitofusin PF04799.8 KOO53740.1 - 3.3 7.0 11.7 19 4.6 0.0 4.6 5 0 0 5 5 5 0 fzo-like conserved region Pkinase PF00069.20 KOO53741.1 - 6.3e-33 114.0 0.0 1.1e-32 113.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO53741.1 - 7.1e-30 103.9 0.0 1.3e-29 103.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase LRR_8 PF13855.1 KOO53741.1 - 2.3e-06 27.2 0.1 5.3e-06 26.0 0.1 1.6 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.2 KOO53741.1 - 9.1e-05 21.9 3.6 0.0031 17.1 0.3 2.4 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) RRM_6 PF14259.1 KOO53741.1 - 0.0035 17.2 0.1 0.013 15.4 0.0 2.0 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Kinase-like PF14531.1 KOO53741.1 - 0.0064 15.4 0.0 0.012 14.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like LRR_1 PF00560.28 KOO53741.1 - 0.012 15.5 0.1 0.078 13.0 0.0 2.5 2 0 0 2 2 2 0 Leucine Rich Repeat LRR_6 PF13516.1 KOO53741.1 - 0.017 15.1 0.0 0.44 10.7 0.0 3.2 3 0 0 3 3 3 0 Leucine Rich repeat RRM_1 PF00076.17 KOO53741.1 - 0.028 14.0 0.1 0.089 12.4 0.1 2.0 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LRR_7 PF13504.1 KOO53741.1 - 0.13 12.5 0.2 2 8.9 0.1 3.0 2 0 0 2 2 2 0 Leucine rich repeat TPR_12 PF13424.1 KOO53742.1 - 6.4e-18 64.4 0.1 3.7e-10 39.5 0.0 4.8 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.1 KOO53742.1 - 1.9e-07 30.7 0.0 1.9e-07 30.7 0.0 4.4 5 2 1 6 6 6 1 Tetratricopeptide repeat PDZ PF00595.19 KOO53742.1 - 4.5e-07 29.9 0.1 1.4e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 KOO53742.1 - 6e-05 22.8 0.2 0.00051 19.8 0.1 2.5 2 0 0 2 2 2 1 PDZ domain Spc7 PF08317.6 KOO53742.1 - 0.11 11.0 25.7 0.12 10.9 10.6 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein V_ATPase_I PF01496.14 KOO53742.1 - 9.8 3.8 14.1 16 3.1 9.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4353 PF14262.1 KOO53745.1 - 0.047 12.9 1.0 0.058 12.6 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4353) TerD PF02342.13 KOO53746.1 - 1.8e-17 63.2 0.0 3.7e-17 62.2 0.0 1.4 1 0 0 1 1 1 1 TerD domain F-box-like PF12937.2 KOO53746.1 - 0.0078 15.9 1.0 0.021 14.5 0.7 1.7 1 0 0 1 1 1 1 F-box-like Nop53 PF07767.6 KOO53746.1 - 0.05 12.5 1.7 0.074 12.0 1.2 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Helicase_C PF00271.26 KOO53747.1 - 1.7e-12 47.0 0.0 2.9e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 KOO53748.1 - 1.1e-51 175.4 0.0 1.7e-51 174.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain HEAT PF02985.17 KOO53748.1 - 0.0011 18.8 0.9 0.02 14.9 0.1 3.3 3 0 0 3 3 3 1 HEAT repeat Sugar_tr PF00083.19 KOO53751.1 - 7.7e-87 291.7 15.7 9.1e-87 291.4 10.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 KOO53751.1 - 1.6e-29 102.7 63.6 2.6e-26 92.1 25.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 KOO53751.1 - 2e-05 23.0 2.2 2e-05 23.0 1.5 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.1 KOO53751.1 - 0.00012 20.5 19.6 0.0058 15.0 4.1 2.7 3 0 0 3 3 3 2 MFS/sugar transport protein DUF791 PF05631.9 KOO53751.1 - 0.17 10.5 4.9 0.032 12.9 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF791) DUF4558 PF15104.1 KOO53753.1 - 7.9e-12 44.9 5.8 9.5e-12 44.6 4.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4558) DUF310 PF03750.8 KOO53753.1 - 0.017 15.3 1.5 0.02 15.0 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF310) HWE_HK PF07536.9 KOO53753.1 - 0.02 15.2 1.2 0.08 13.3 0.5 1.9 1 1 0 2 2 2 0 HWE histidine kinase Imm42 PF15601.1 KOO53753.1 - 0.092 12.1 0.2 0.096 12.1 0.2 1.1 1 0 0 1 1 1 0 Immunity protein 42 CHASE3 PF05227.8 KOO53753.1 - 0.24 11.0 6.3 0.33 10.6 4.3 1.2 1 0 0 1 1 1 0 CHASE3 domain Pinin_SDK_memA PF04696.8 KOO53753.1 - 0.26 10.8 6.7 0.36 10.4 4.3 1.5 1 1 0 1 1 1 0 pinin/SDK/memA/ protein conserved region LTXXQ PF07813.7 KOO53753.1 - 0.88 10.0 12.3 2.1 8.8 4.4 2.1 1 1 1 2 2 2 0 LTXXQ motif family protein E_Pc_C PF06752.7 KOO53754.1 - 0.011 15.2 2.8 0.02 14.4 2.0 1.3 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus TMF_TATA_bd PF12325.3 KOO53754.1 - 0.064 12.9 1.2 0.097 12.4 0.8 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Siah-Interact_N PF09032.6 KOO53754.1 - 0.078 13.0 3.3 0.15 12.1 2.3 1.4 1 0 0 1 1 1 0 Siah interacting protein, N terminal Acid_PPase PF12689.2 KOO53755.1 - 2.2e-23 82.7 0.0 4e-23 81.8 0.0 1.4 1 1 0 1 1 1 1 Acid Phosphatase RRM_1 PF00076.17 KOO53757.1 - 1.6e-19 69.3 0.0 4e-19 68.0 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1601 PF07671.6 KOO53757.1 - 1.8e-16 59.4 25.8 0.0028 17.2 0.7 7.8 2 2 5 7 7 7 4 Protein of unknown function (DUF1601) FAST_1 PF06743.10 KOO53757.1 - 1e-14 53.9 0.0 0.17 11.6 0.0 7.3 2 2 5 7 7 7 5 FAST kinase-like protein, subdomain 1 RRM_6 PF14259.1 KOO53757.1 - 2.5e-12 46.5 0.0 1e-11 44.6 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RAP PF08373.5 KOO53757.1 - 4.5e-12 45.5 0.0 1e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 RAP domain Ank_2 PF12796.2 KOO53757.1 - 1.7e-11 44.3 0.0 9e-11 41.9 0.0 2.3 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO53757.1 - 3.4e-11 42.3 0.2 2.2e-08 33.5 0.0 4.1 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.1 KOO53757.1 - 7.9e-10 38.6 0.7 5.2e-09 36.0 0.1 2.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO53757.1 - 5.1e-08 33.2 0.0 8.9e-07 29.2 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeats (many copies) RRM_5 PF13893.1 KOO53757.1 - 1.5e-07 31.1 0.0 3.8e-07 29.8 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ank_3 PF13606.1 KOO53757.1 - 3.7e-06 26.6 0.0 0.00031 20.6 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeat FAST_2 PF08368.7 KOO53757.1 - 0.05 13.9 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 2 DUF445 PF04286.7 KOO53757.1 - 0.11 12.0 0.0 1.2 8.5 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF445) Ank_3 PF13606.1 KOO53758.1 - 0.0014 18.6 0.1 2.2 8.7 0.0 4.2 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.25 KOO53758.1 - 0.0025 17.5 1.2 10 6.1 0.0 4.7 5 0 0 5 5 5 2 Ankyrin repeat Ank_2 PF12796.2 KOO53758.1 - 0.011 16.0 0.0 0.77 10.1 0.0 3.0 2 1 1 3 3 3 0 Ankyrin repeats (3 copies) Ank_5 PF13857.1 KOO53758.1 - 0.014 15.5 0.1 3.7 7.9 0.0 3.3 3 0 0 3 3 3 0 Ankyrin repeats (many copies) PufQ PF05398.6 KOO53758.1 - 3.1 7.8 7.3 14 5.7 0.2 3.0 3 0 0 3 3 3 0 PufQ cytochrome subunit Phage_integrase PF00589.17 KOO53759.1 - 0.00053 19.7 0.1 0.0011 18.7 0.0 1.5 2 0 0 2 2 2 1 Phage integrase family DUF3007 PF11460.3 KOO53760.1 - 5.3e-19 68.2 0.1 7e-19 67.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3007) EamA PF00892.15 KOO53760.1 - 0.026 14.5 0.5 0.051 13.6 0.2 1.5 1 1 0 1 1 1 0 EamA-like transporter family SNARE PF05739.14 KOO53761.1 - 1.9e-16 59.5 4.5 5.8e-16 57.9 1.0 3.0 3 0 0 3 3 3 1 SNARE domain Syntaxin PF00804.20 KOO53761.1 - 2.9e-06 27.3 1.4 1e-05 25.5 0.0 2.3 2 0 0 2 2 2 1 Syntaxin GBP PF02263.14 KOO53761.1 - 7.4e-05 21.9 0.0 0.00025 20.2 0.0 1.9 2 1 0 2 2 2 1 Guanylate-binding protein, N-terminal domain Syntaxin_2 PF14523.1 KOO53761.1 - 0.0026 17.7 1.4 0.0054 16.7 0.1 2.2 2 0 0 2 2 2 1 Syntaxin-like protein DUF2408 PF10303.4 KOO53761.1 - 0.31 11.1 1.3 0.5 10.4 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) SAM_1 PF00536.25 KOO53762.1 - 2.3e-11 43.7 0.0 4.7e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Cyclin PF08613.6 KOO53762.1 - 5.3e-10 39.8 0.0 1.1e-09 38.9 0.0 1.6 1 0 0 1 1 1 1 Cyclin SAM_2 PF07647.12 KOO53762.1 - 1.9e-09 37.2 0.0 4.1e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Cyclin_N PF00134.18 KOO53762.1 - 1.5e-08 34.2 0.3 3.5e-08 33.0 0.2 1.7 1 0 0 1 1 1 1 Cyclin, N-terminal domain Dynein_heavy PF03028.10 KOO53762.1 - 1.7e-05 23.1 0.9 2.6e-05 22.4 0.0 1.6 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor Cytochrom_C_2 PF01322.15 KOO53762.1 - 1.8 9.1 7.4 15 6.1 3.0 2.4 2 0 0 2 2 2 0 Cytochrome C' Sulfotransfer_2 PF03567.9 KOO53763.1 - 0.01 15.5 0.0 0.11 12.1 0.0 2.3 1 1 0 1 1 1 0 Sulfotransferase family WD40 PF00400.27 KOO53764.1 - 2.2e-10 39.9 0.1 0.00017 21.3 0.0 3.6 3 0 0 3 3 3 3 WD domain, G-beta repeat Apc4_WD40 PF12894.2 KOO53764.1 - 0.014 14.8 0.0 0.031 13.7 0.0 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.1 KOO53764.1 - 0.2 11.9 2.4 13 6.2 0.0 4.0 3 1 1 4 4 4 0 PQQ-like domain DUF399 PF04187.8 KOO53765.1 - 2e-23 83.0 0.0 1.3e-21 77.1 0.0 2.3 1 1 1 2 2 2 2 Protein of unknown function, DUF399 Sel1 PF08238.7 KOO53765.1 - 5.8e-14 52.1 0.2 8.8e-06 26.1 0.1 3.9 3 0 0 3 3 3 3 Sel1 repeat Patatin PF01734.17 KOO53765.1 - 5.6e-05 23.1 0.0 0.0002 21.3 0.0 1.9 2 0 0 2 2 2 1 Patatin-like phospholipase DUF1814 PF08843.6 KOO53765.1 - 0.12 12.1 1.9 0.2 11.3 1.3 1.4 1 0 0 1 1 1 0 Nucleotidyl transferase of unknown function (DUF1814) Asparaginase PF00710.15 KOO53767.1 - 1.7e-98 329.3 0.0 2e-98 329.1 0.0 1.0 1 0 0 1 1 1 1 Asparaginase Pex14_N PF04695.8 KOO53767.1 - 0.17 11.9 0.1 0.88 9.6 0.0 2.0 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region HEAT PF02985.17 KOO53768.1 - 4.2e-15 54.3 9.8 0.012 15.6 0.2 5.9 5 0 0 5 5 5 5 HEAT repeat Pkinase PF00069.20 KOO53768.1 - 9.6e-12 44.5 0.0 5.5e-11 42.0 0.0 1.9 1 1 0 2 2 2 1 Protein kinase domain HEAT_2 PF13646.1 KOO53768.1 - 3.6e-08 33.5 8.1 0.00045 20.4 0.7 4.3 3 1 1 4 4 4 3 HEAT repeats APH PF01636.18 KOO53768.1 - 0.00076 19.2 2.7 0.012 15.3 0.1 3.2 2 1 1 3 3 3 1 Phosphotransferase enzyme family WD40 PF00400.27 KOO53768.1 - 0.007 16.2 0.1 0.16 11.8 0.0 2.7 2 0 0 2 2 2 1 WD domain, G-beta repeat Pkinase_Tyr PF07714.12 KOO53768.1 - 0.015 14.4 0.0 0.024 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase Nipped-B_C PF12830.2 KOO53768.1 - 0.017 14.7 0.2 0.097 12.3 0.0 2.3 2 0 0 2 2 2 0 Sister chromatid cohesion C-terminus Adaptin_N PF01602.15 KOO53768.1 - 0.017 13.4 0.9 1.3 7.2 0.1 2.3 1 1 0 2 2 2 0 Adaptin N terminal region HEAT_EZ PF13513.1 KOO53768.1 - 0.1 13.1 11.0 0.97 10.0 0.1 5.5 4 1 1 5 5 5 0 HEAT-like repeat TPR_11 PF13414.1 KOO53769.1 - 4.8e-16 58.1 10.6 4.1e-13 48.7 1.7 3.0 2 1 0 2 2 2 2 TPR repeat TPR_2 PF07719.12 KOO53769.1 - 8.8e-10 37.7 17.0 0.0048 16.7 0.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 KOO53769.1 - 7e-08 31.7 10.5 0.0025 17.3 0.4 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat UBA PF00627.26 KOO53769.1 - 2.6e-05 23.9 0.1 6.8e-05 22.5 0.1 1.8 1 0 0 1 1 1 1 UBA/TS-N domain TPR_8 PF13181.1 KOO53769.1 - 0.00076 19.0 3.8 0.27 11.0 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 KOO53769.1 - 0.0047 17.5 3.9 0.0047 17.5 2.7 5.5 3 3 5 8 8 8 3 Tetratricopeptide repeat TPR_12 PF13424.1 KOO53769.1 - 0.011 15.6 14.8 0.026 14.4 1.4 3.3 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.1 KOO53769.1 - 0.054 13.7 1.1 4.9 7.6 0.0 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.1 KOO53769.1 - 0.17 11.7 8.0 2.5 8.1 0.1 4.5 3 1 1 4 4 4 0 Tetratricopeptide repeat SMAP PF15477.1 KOO53769.1 - 6.3 7.1 10.1 1.1 9.6 2.2 3.1 2 0 0 2 2 2 0 Small acidic protein family EF-hand_5 PF13202.1 KOO53770.1 - 0.00014 20.9 0.0 0.00026 20.1 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.27 KOO53770.1 - 0.00025 20.1 0.0 0.00046 19.3 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 KOO53770.1 - 0.029 14.2 0.0 0.065 13.1 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.1 KOO53770.1 - 0.034 14.3 0.0 0.056 13.5 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair Mg_trans_NIPA PF05653.9 KOO53770.1 - 0.064 12.2 0.1 0.095 11.6 0.1 1.2 1 0 0 1 1 1 0 Magnesium transporter NIPA EF-hand_8 PF13833.1 KOO53770.1 - 0.16 11.6 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair SH3_3 PF08239.6 KOO53772.1 - 6.7e-05 23.0 0.3 0.00017 21.6 0.2 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain WD40 PF00400.27 KOO53773.1 - 0.00044 20.0 5.2 0.011 15.6 0.0 4.2 4 1 0 4 4 4 1 WD domain, G-beta repeat PQQ_3 PF13570.1 KOO53773.1 - 0.056 13.7 4.6 36 4.8 0.0 4.5 4 0 0 4 4 4 0 PQQ-like domain DUF342 PF03961.8 KOO53773.1 - 1.2 7.4 6.2 2.1 6.6 4.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF342) TACC PF05010.9 KOO53773.1 - 2.9 7.5 14.4 4.5 6.9 10.0 1.2 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) EURL PF06937.6 KOO53773.1 - 7.3 5.9 8.9 12 5.2 6.2 1.2 1 0 0 1 1 1 0 EURL protein COX16 PF14138.1 KOO53775.1 - 0.017 15.2 0.1 0.025 14.7 0.1 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 PP2C PF00481.16 KOO53776.1 - 8.2e-34 117.1 0.0 2.3e-33 115.6 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.1 KOO53776.1 - 0.099 12.0 2.8 0.93 8.8 1.7 2.1 2 0 0 2 2 2 0 Protein phosphatase 2C Methyltransf_22 PF13383.1 KOO53779.1 - 9.5e-15 54.7 0.0 1.5e-13 50.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain CRAL_TRIO PF00650.15 KOO53779.1 - 6.5e-11 41.9 0.0 1.1e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain Methyltransf_21 PF05050.7 KOO53779.1 - 2e-06 27.8 0.0 4.3e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_18 PF12847.2 KOO53779.1 - 0.066 13.7 0.0 0.72 10.4 0.0 2.6 2 1 0 2 2 2 0 Methyltransferase domain Laminin_G_3 PF13385.1 KOO53781.1 - 9.5e-08 32.4 0.0 1.6e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily EF-hand_5 PF13202.1 KOO53781.1 - 0.00067 18.8 0.5 0.0022 17.2 0.1 2.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.1 KOO53781.1 - 0.0087 15.8 0.2 0.048 13.5 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.27 KOO53781.1 - 0.013 14.7 0.4 0.085 12.2 0.2 2.4 2 0 0 2 2 2 0 EF hand C2 PF00168.25 KOO53782.1 - 4.2e-17 61.7 0.0 8.2e-17 60.8 0.0 1.5 1 0 0 1 1 1 1 C2 domain Ion_trans PF00520.26 KOO53782.1 - 2.3e-11 43.3 1.9 2.3e-11 43.3 1.3 1.8 2 0 0 2 2 2 1 Ion transport protein cNMP_binding PF00027.24 KOO53782.1 - 0.0032 17.2 0.0 0.0062 16.3 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_N PF08412.5 KOO53782.1 - 0.0048 16.1 0.1 0.012 14.9 0.1 1.7 1 0 0 1 1 1 1 Ion transport protein N-terminal CDRT4 PF15213.1 KOO53782.1 - 0.087 12.9 0.9 0.2 11.7 0.6 1.5 1 0 0 1 1 1 0 CMT1A duplicated region transcript 4 protein Lig_chan PF00060.21 KOO53782.1 - 0.49 10.0 5.8 0.18 11.5 0.2 2.3 2 0 0 2 2 2 0 Ligand-gated ion channel Methyltransf_23 PF13489.1 KOO53783.1 - 2.1e-06 27.5 0.0 2.6e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 KOO53783.1 - 0.0037 17.7 0.0 0.0048 17.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO53783.1 - 0.014 15.8 0.0 0.025 15.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain FWWh PF14922.1 KOO53785.1 - 9.9e-17 60.8 0.0 2e-16 59.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function Filamin PF00630.14 KOO53787.1 - 4.4e-13 49.6 0.0 7e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 Filamin/ABP280 repeat DUF3725 PF12523.3 KOO53787.1 - 0.12 12.5 0.1 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3725) Peptidase_M36 PF02128.10 KOO53787.1 - 0.25 10.1 0.0 0.4 9.4 0.0 1.2 1 0 0 1 1 1 0 Fungalysin metallopeptidase (M36) SAC3 PF12209.3 KOO53788.1 - 0.062 13.4 0.1 0.14 12.3 0.0 1.6 1 1 0 1 1 1 0 Leucine permease transcriptional regulator helical domain TerB-C PF15615.1 KOO53788.1 - 0.79 9.9 6.1 1.1 9.4 2.9 2.3 1 1 2 3 3 3 0 TerB-C domain PIN_4 PF13638.1 KOO53789.1 - 0.049 13.7 0.2 0.23 11.5 0.0 2.2 2 0 0 2 2 2 0 PIN domain DUF2152 PF10222.4 KOO53789.1 - 0.087 11.0 0.0 0.18 9.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2152) TPR_1 PF00515.23 KOO53789.1 - 0.34 10.5 3.9 40 4.0 0.1 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat RCC1 PF00415.13 KOO53790.1 - 6.8e-41 138.2 30.2 2.3e-07 30.9 0.4 6.6 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 KOO53790.1 - 2.8e-32 109.6 50.1 2.4e-07 30.2 1.1 6.4 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat URO-D PF01208.12 KOO53792.1 - 3e-93 312.4 0.0 4.9e-93 311.7 0.0 1.3 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) DUF4229 PF14012.1 KOO53793.1 - 0.36 10.7 2.0 0.77 9.6 1.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4229) DEAD PF00270.24 KOO53794.1 - 2.3e-15 56.5 0.0 5.7e-15 55.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO53794.1 - 5.2e-10 39.0 0.0 1.1e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain TauE PF01925.14 KOO53795.1 - 1.4e-23 83.5 37.8 3.2e-12 46.4 14.5 2.2 2 0 0 2 2 2 2 Sulfite exporter TauE/SafE EF-hand_1 PF00036.27 KOO53796.1 - 9.8e-31 102.7 6.0 1.8e-06 26.8 0.1 6.9 6 0 0 6 6 6 6 EF hand EF-hand_6 PF13405.1 KOO53796.1 - 6.8e-29 97.1 5.3 2.4e-06 26.9 0.0 7.4 6 0 0 6 6 6 5 EF-hand domain EF-hand_7 PF13499.1 KOO53796.1 - 8.7e-26 89.8 5.0 3.6e-09 36.6 0.1 3.7 3 0 0 3 3 3 3 EF-hand domain pair Pentapeptide_4 PF13599.1 KOO53796.1 - 2.3e-22 78.5 0.0 6.4e-07 29.0 0.0 7.0 4 2 1 7 7 7 3 Pentapeptide repeats (9 copies) EF-hand_5 PF13202.1 KOO53796.1 - 8.7e-20 69.1 6.1 0.0012 18.1 0.4 6.6 6 0 0 6 6 6 5 EF hand EF-hand_10 PF14788.1 KOO53796.1 - 4.2e-09 35.9 2.3 0.00087 18.9 0.0 4.5 4 2 2 6 6 6 3 EF hand EF-hand_8 PF13833.1 KOO53796.1 - 2.3e-06 27.1 12.8 0.11 12.0 0.1 6.6 5 2 2 7 7 7 4 EF-hand domain pair SinI PF08671.5 KOO53796.1 - 0.013 14.9 0.0 0.057 12.8 0.0 2.2 1 0 0 1 1 1 0 Anti-repressor SinI SH3_3 PF08239.6 KOO53796.1 - 0.013 15.6 0.0 0.049 13.8 0.0 2.0 1 0 0 1 1 1 0 Bacterial SH3 domain Phage_tail_3 PF08813.6 KOO53796.1 - 0.039 13.3 0.0 0.08 12.3 0.0 1.5 1 0 0 1 1 1 0 Phage tail protein N_methyl_2 PF13544.1 KOO53796.1 - 0.11 12.0 0.1 18 4.9 0.0 3.8 3 0 0 3 3 3 0 Type IV pilin N-term methylation site GFxxxE TFIIA_gamma_N PF02268.11 KOO53796.1 - 0.12 12.0 0.0 12 5.6 0.0 3.5 4 0 0 4 4 4 0 Transcription initiation factor IIA, gamma subunit, helical domain FRG1 PF06229.7 KOO53797.1 - 0.16 11.3 2.6 0.29 10.5 1.8 1.4 1 0 0 1 1 1 0 FRG1-like family GrpE PF01025.14 KOO53798.1 - 1.7e-43 148.0 0.1 2.5e-43 147.4 0.0 1.1 1 0 0 1 1 1 1 GrpE Mito_carr PF00153.22 KOO53798.1 - 3.5e-15 55.4 0.0 8.6e-15 54.2 0.0 1.6 2 0 0 2 2 2 1 Mitochondrial carrier protein Chloroa_b-bind PF00504.16 KOO53799.1 - 7.9e-21 74.9 0.1 1.8e-20 73.7 0.0 1.6 1 0 0 1 1 1 1 Chlorophyll A-B binding protein Rootletin PF15035.1 KOO53799.1 - 0.039 13.9 0.9 0.092 12.7 0.6 1.5 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion EF-hand_6 PF13405.1 KOO53800.1 - 4e-23 79.1 1.1 0.00011 21.7 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.27 KOO53800.1 - 3.1e-22 76.1 8.2 7.7e-06 24.8 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 KOO53800.1 - 1.1e-19 70.3 0.1 2.4e-09 37.1 0.1 3.5 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.1 KOO53800.1 - 1.8e-15 56.2 3.1 3.7e-07 29.6 0.1 3.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 KOO53800.1 - 5.9e-15 53.8 6.5 0.0063 15.8 0.0 4.6 4 0 0 4 4 4 4 EF hand IQ PF00612.22 KOO53800.1 - 1.5e-13 49.0 52.3 0.014 14.9 0.1 10.6 10 0 0 10 10 10 7 IQ calmodulin-binding motif Fer4_6 PF12837.2 KOO53802.1 - 0.0097 15.7 0.6 0.017 15.0 0.4 1.4 1 0 0 1 1 1 1 4Fe-4S binding domain DUF2058 PF09831.4 KOO53802.1 - 0.16 11.8 5.5 0.19 11.5 3.8 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) PC_rep PF01851.17 KOO53804.1 - 6.1e-42 139.5 15.6 1.8e-07 30.9 0.1 9.4 9 0 0 9 9 9 7 Proteasome/cyclosome repeat HEAT_2 PF13646.1 KOO53804.1 - 2.6e-19 69.2 3.4 5.8e-09 36.1 0.0 5.6 3 1 2 5 5 5 4 HEAT repeats HEAT PF02985.17 KOO53804.1 - 9.4e-07 28.4 0.3 1.4 9.1 0.1 5.2 4 0 0 4 4 4 3 HEAT repeat HEAT_EZ PF13513.1 KOO53804.1 - 1.1e-05 25.8 9.1 0.016 15.7 0.0 5.6 5 1 2 7 7 7 4 HEAT-like repeat MORN PF02493.15 KOO53807.1 - 1.6e-41 137.5 40.5 7e-08 31.7 0.6 9.8 9 1 0 9 9 9 8 MORN repeat AIG2_2 PF13772.1 KOO53807.1 - 0.0015 18.6 0.0 0.004 17.2 0.0 1.7 1 0 0 1 1 1 1 AIG2-like family WD40 PF00400.27 KOO53808.1 - 7.8e-25 85.8 5.2 4.8e-05 23.0 0.1 6.7 5 1 0 5 5 5 5 WD domain, G-beta repeat rve PF00665.21 KOO53812.1 - 3.3e-05 23.9 0.0 0.00014 21.9 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain ClpS PF02617.12 KOO53813.1 - 3.3e-19 68.3 0.1 5.2e-19 67.7 0.0 1.3 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS MFS_2 PF13347.1 KOO53813.1 - 0.047 12.0 0.0 0.071 11.5 0.0 1.2 1 0 0 1 1 1 0 MFS/sugar transport protein Oscp1 PF10188.4 KOO53815.1 - 1.2e-58 197.8 3.2 1.6e-58 197.3 2.2 1.2 1 0 0 1 1 1 1 Organic solute transport protein 1 Herpes_IE68 PF02479.11 KOO53815.1 - 0.13 11.4 0.0 0.24 10.6 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus immediate early protein Tubulin PF00091.20 KOO53816.1 - 4.5e-47 160.6 0.0 4.9e-47 160.5 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain zf-CCCH PF00642.19 KOO53817.1 - 0.012 15.2 2.8 0.02 14.6 1.9 1.3 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.17 KOO53819.1 - 9.6e-13 47.5 0.0 1.3e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 KOO53819.1 - 1.8e-10 40.6 0.0 2.5e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 KOO53819.1 - 3.3e-07 30.0 0.0 4.7e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TIR_2 PF13676.1 KOO53820.1 - 2.3e-05 24.4 0.0 5.2e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 TIR domain TIR PF01582.15 KOO53820.1 - 0.037 13.4 0.0 0.061 12.7 0.0 1.4 1 0 0 1 1 1 0 TIR domain LRRC37AB_C PF14914.1 KOO53821.1 - 0.098 12.0 0.3 0.11 11.9 0.2 1.1 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain DUF2786 PF10979.3 KOO53822.1 - 1.3e-07 31.1 6.0 1.3e-07 31.1 4.2 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2786) UBA_4 PF14555.1 KOO53823.1 - 6.4e-11 41.5 0.1 1.5e-10 40.3 0.1 1.7 1 0 0 1 1 1 1 UBA-like domain SEP PF08059.8 KOO53823.1 - 3.9e-06 27.0 0.1 0.15 12.3 0.0 4.4 5 0 0 5 5 5 2 SEP domain UBX PF00789.15 KOO53823.1 - 0.00029 20.8 0.0 0.0006 19.8 0.0 1.6 1 0 0 1 1 1 1 UBX domain Galactosyl_T PF01762.16 KOO53824.1 - 0.075 12.6 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Galactosyltransferase Fringe PF02434.11 KOO53824.1 - 0.14 11.3 0.0 0.97 8.5 0.0 2.0 1 1 0 1 1 1 0 Fringe-like SAM_2 PF07647.12 KOO53825.1 - 0.049 13.4 0.0 0.1 12.4 0.0 1.5 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 KOO53825.1 - 0.15 12.2 0.2 1.3 9.2 0.0 2.0 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Na_Ca_ex PF01699.19 KOO53827.1 - 3.8e-32 110.8 29.2 1.3e-16 60.4 6.8 2.4 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Ank_2 PF12796.2 KOO53828.1 - 1.6e-17 63.6 0.1 5.9e-12 45.7 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO53828.1 - 1.3e-11 43.6 0.3 2.2e-05 23.9 0.2 3.1 3 0 0 3 3 3 2 Ankyrin repeat DNA_pol_A_exo1 PF01612.15 KOO53828.1 - 1.3e-09 37.8 0.0 2.2e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 3'-5' exonuclease Ank_4 PF13637.1 KOO53828.1 - 3.4e-09 36.9 0.7 0.0011 19.4 0.0 3.2 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO53828.1 - 7.2e-09 35.6 0.1 0.00041 20.4 0.1 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO53828.1 - 6.4e-08 32.0 0.2 0.0017 18.3 0.1 3.0 3 0 0 3 3 3 2 Ankyrin repeat C2 PF00168.25 KOO53829.1 - 1.4e-14 53.6 0.0 3e-14 52.6 0.0 1.6 1 0 0 1 1 1 1 C2 domain Ank_2 PF12796.2 KOO53829.1 - 2.1e-12 47.2 0.1 4.2e-12 46.2 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 KOO53829.1 - 4e-10 38.9 0.3 4e-07 29.5 0.1 3.6 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.1 KOO53829.1 - 4.9e-10 39.6 2.0 1.5e-05 25.3 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) EF-hand_6 PF13405.1 KOO53829.1 - 6.3e-10 38.0 0.3 5.1e-07 29.0 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain Ank_5 PF13857.1 KOO53829.1 - 1.5e-09 37.8 0.5 5.9e-09 35.8 0.4 2.0 1 1 1 2 2 2 1 Ankyrin repeats (many copies) EF-hand_1 PF00036.27 KOO53829.1 - 2.6e-07 29.4 0.0 2.4e-06 26.4 0.0 2.3 2 0 0 2 2 2 1 EF hand Ank_3 PF13606.1 KOO53829.1 - 2.7e-07 30.1 0.0 1.7e-05 24.5 0.0 3.3 4 0 0 4 4 4 1 Ankyrin repeat EF-hand_5 PF13202.1 KOO53829.1 - 3.1e-06 26.2 0.3 1.9e-05 23.7 0.1 2.2 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.1 KOO53829.1 - 3.4e-06 27.0 0.1 6.6e-06 26.1 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair Transcrip_reg PF01709.15 KOO53831.1 - 3e-62 209.7 2.3 3.4e-62 209.6 1.6 1.0 1 0 0 1 1 1 1 Transcriptional regulator NT-C2 PF10358.4 KOO53832.1 - 4e-09 36.1 0.0 6.9e-09 35.3 0.0 1.4 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins Cep57_CLD_2 PF14197.1 KOO53832.1 - 0.0089 15.9 7.9 0.016 15.1 1.3 2.5 1 1 1 2 2 2 2 Centrosome localisation domain of PPC89 IncA PF04156.9 KOO53832.1 - 0.93 9.0 5.6 1.5 8.3 3.9 1.2 1 0 0 1 1 1 0 IncA protein APG6 PF04111.7 KOO53832.1 - 1.3 7.9 5.9 2.1 7.2 4.1 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 Pkinase PF00069.20 KOO53833.1 - 6.9e-59 199.1 0.0 8.9e-59 198.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 KOO53833.1 - 1.9e-44 151.6 0.0 2.5e-44 151.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 KOO53833.1 - 8.5e-06 24.9 0.0 1.3e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Mito_fiss_reg PF05308.6 KOO53833.1 - 1.3 8.3 7.0 2.3 7.5 4.9 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator Fumerase PF05681.9 KOO53837.1 - 1e-89 300.2 0.0 1.2e-89 299.9 0.0 1.1 1 0 0 1 1 1 1 Fumarate hydratase (Fumerase) Fumerase_C PF05683.7 KOO53837.1 - 6.4e-79 263.8 0.0 1.2e-78 263.0 0.0 1.4 1 0 0 1 1 1 1 Fumarase C-terminus IBN_N PF03810.14 KOO53837.1 - 0.025 14.4 0.1 0.053 13.4 0.1 1.5 1 0 0 1 1 1 0 Importin-beta N-terminal domain Ank_2 PF12796.2 KOO53838.1 - 2.9e-50 168.5 17.0 4.4e-18 65.3 1.3 4.4 2 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.25 KOO53838.1 - 4.6e-45 149.2 28.5 1.2e-06 28.0 0.0 10.5 10 1 0 10 10 10 9 Ankyrin repeat Ank_4 PF13637.1 KOO53838.1 - 8.3e-38 128.1 6.3 2e-07 31.3 0.0 6.1 4 1 2 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.1 KOO53838.1 - 2e-32 110.4 23.6 2.6e-06 27.4 0.1 9.1 2 1 7 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO53838.1 - 1.5e-30 102.1 11.1 0.011 15.8 0.0 10.1 10 0 0 10 10 10 8 Ankyrin repeat F-box PF00646.28 KOO53838.1 - 0.00028 20.4 0.0 0.00056 19.5 0.0 1.5 1 0 0 1 1 1 1 F-box domain GLTT PF01744.15 KOO53838.1 - 0.012 15.0 0.9 0.025 13.9 0.6 1.5 1 0 0 1 1 1 0 GLTT repeat (6 copies) HAD PF12710.2 KOO53839.1 - 0.00043 20.4 0.0 0.00063 19.9 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PBP_like_2 PF12849.2 KOO53839.1 - 0.045 13.2 0.0 0.062 12.7 0.0 1.2 1 0 0 1 1 1 0 PBP superfamily domain HAD_2 PF13419.1 KOO53839.1 - 0.084 13.0 0.1 14 5.9 0.0 2.4 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF3987 PF13148.1 KOO53841.1 - 2.7e-05 22.9 0.1 0.0036 15.9 0.0 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF3987) SpoVS PF04232.7 KOO53842.1 - 6.8e-45 150.5 2.4 3.2e-26 90.7 0.3 2.3 2 0 0 2 2 2 2 Stage V sporulation protein S (SpoVS) FumaraseC_C PF10415.4 KOO53842.1 - 0.083 12.9 0.0 1.8 8.7 0.0 2.6 2 0 0 2 2 2 0 Fumarase C C-terminus cobW PF02492.14 KOO53843.1 - 1.4e-45 154.9 0.1 1.8e-45 154.5 0.1 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.9 KOO53843.1 - 3.8e-06 26.5 0.0 8.9e-06 25.3 0.0 1.7 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_22 PF13401.1 KOO53843.1 - 0.0054 16.8 0.1 0.081 13.0 0.0 2.7 3 0 0 3 3 3 1 AAA domain ArgK PF03308.11 KOO53843.1 - 0.0062 15.3 0.8 2.7 6.6 0.0 2.7 3 0 0 3 3 3 2 ArgK protein DUF258 PF03193.11 KOO53843.1 - 0.098 11.8 0.1 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 KOO53843.1 - 0.17 11.4 0.9 0.66 9.5 0.1 2.3 3 0 0 3 3 3 0 P-loop containing region of AAA domain Corona_nucleoca PF00937.13 KOO53843.1 - 1.3 7.9 3.6 1.8 7.4 2.5 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein MMR_HSR1 PF01926.18 KOO53845.1 - 1.1e-14 54.3 0.0 2.1e-14 53.4 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 KOO53845.1 - 2.1e-08 34.1 0.0 0.0037 17.1 0.1 2.2 1 1 1 2 2 2 2 Dynamin family DUF258 PF03193.11 KOO53845.1 - 5.1e-06 25.7 0.0 1.1e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 KOO53845.1 - 4.6e-05 22.9 0.0 0.012 15.0 0.0 2.1 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 KOO53845.1 - 7.5e-05 22.0 0.0 0.00016 21.0 0.0 1.5 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_16 PF13191.1 KOO53845.1 - 0.00027 20.9 0.3 0.0066 16.4 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain Miro PF08477.8 KOO53845.1 - 0.0034 17.8 0.1 0.011 16.2 0.0 1.9 1 1 0 1 1 1 1 Miro-like protein AAA_22 PF13401.1 KOO53845.1 - 0.0074 16.4 0.0 0.021 14.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.5 KOO53845.1 - 0.0076 15.4 0.0 0.012 14.8 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AIG1 PF04548.11 KOO53845.1 - 0.011 14.9 0.0 0.023 13.8 0.0 1.7 1 1 0 1 1 1 0 AIG1 family AAA_10 PF12846.2 KOO53845.1 - 0.04 13.3 0.1 0.13 11.6 0.0 1.9 2 2 0 2 2 2 0 AAA-like domain FtsK_SpoIIIE PF01580.13 KOO53845.1 - 0.067 12.6 1.2 0.12 11.8 0.1 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family Guanylate_kin PF00625.16 KOO53845.1 - 0.087 12.2 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Guanylate kinase RNA_helicase PF00910.17 KOO53845.1 - 0.091 12.9 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.22 KOO53845.1 - 0.098 12.9 0.0 0.11 12.7 0.0 1.5 1 1 0 1 1 1 0 ABC transporter Methyltransf_8 PF05148.10 KOO53845.1 - 0.1 12.1 0.0 0.31 10.6 0.0 1.8 1 1 1 2 2 2 0 Hypothetical methyltransferase MobB PF03205.9 KOO53845.1 - 0.11 12.1 0.0 0.28 10.8 0.0 1.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Septin PF00735.13 KOO53845.1 - 0.15 11.0 0.0 0.23 10.4 0.0 1.2 1 0 0 1 1 1 0 Septin Ribosomal_L11_N PF03946.9 KOO53846.1 - 3.8e-27 93.5 0.1 6.4e-27 92.7 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 KOO53846.1 - 1.8e-26 92.0 1.8 1.8e-26 92.0 1.2 1.6 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain PerC PF06069.6 KOO53846.1 - 0.16 12.0 0.4 0.4 10.7 0.0 1.8 2 0 0 2 2 2 0 PerC transcriptional activator AA_permease PF00324.16 KOO53847.1 - 0.0001 20.8 0.4 0.0001 20.8 0.3 1.7 1 1 1 2 2 2 1 Amino acid permease Methyltransf_24 PF13578.1 KOO53847.1 - 0.0078 17.0 0.0 0.016 16.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain WD40 PF00400.27 KOO53848.1 - 3.8e-21 74.1 3.0 0.00014 21.5 0.0 4.8 4 0 0 4 4 4 4 WD domain, G-beta repeat SPX PF03105.14 KOO53849.1 - 0.034 13.9 12.3 0.012 15.3 2.8 3.0 1 1 0 2 2 2 0 SPX domain ELO PF01151.13 KOO53850.1 - 1.1e-39 136.2 11.0 2.2e-39 135.2 7.7 1.4 1 1 0 1 1 1 1 GNS1/SUR4 family Ank_2 PF12796.2 KOO53851.1 - 5.7e-17 61.8 1.6 2.2e-08 34.3 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 KOO53851.1 - 3.1e-13 48.8 11.3 0.002 17.8 0.1 5.6 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.1 KOO53851.1 - 7.3e-12 45.1 5.4 1e-05 25.5 0.0 5.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO53851.1 - 7.3e-12 45.4 1.0 0.008 16.6 0.0 4.3 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO53851.1 - 7.6e-12 44.2 2.1 0.22 11.8 0.0 6.5 6 0 0 6 6 6 3 Ankyrin repeat UVR PF02151.14 KOO53851.1 - 2.4e-06 26.8 5.3 6.7e-06 25.4 3.7 1.8 1 0 0 1 1 1 1 UvrB/uvrC motif RhoGEF PF00621.15 KOO53851.1 - 6.5e-06 26.1 0.0 4.4e-05 23.4 0.0 2.1 2 1 0 2 2 2 1 RhoGEF domain PH PF00169.24 KOO53851.1 - 0.0067 16.6 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 PH domain IQ PF00612.22 KOO53851.1 - 0.028 14.0 0.1 0.087 12.5 0.1 1.9 1 0 0 1 1 1 0 IQ calmodulin-binding motif DUF4618 PF15397.1 KOO53851.1 - 0.16 11.3 0.4 0.3 10.3 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Ribosomal_L6 PF00347.18 KOO53852.1 - 1.7e-13 50.8 0.5 1.7e-13 50.8 0.4 1.7 2 0 0 2 2 2 1 Ribosomal protein L6 FYVE PF01363.16 KOO53853.1 - 6.2e-27 93.2 31.9 1.7e-14 53.4 8.0 2.4 2 0 0 2 2 2 2 FYVE zinc finger FYVE_2 PF02318.11 KOO53853.1 - 0.011 15.6 3.3 0.011 15.6 2.3 2.5 2 0 0 2 2 2 0 FYVE-type zinc finger IBR PF01485.16 KOO53853.1 - 1.2 9.0 19.1 0.094 12.5 2.5 3.2 3 0 0 3 3 3 0 IBR domain zf-DHHC PF01529.15 KOO53853.1 - 3.2 7.1 11.1 0.75 9.1 1.1 2.4 2 0 0 2 2 2 0 DHHC palmitoyltransferase EF-hand_4 PF12763.2 KOO53854.1 - 3.2e-18 65.3 0.0 6.5e-18 64.3 0.0 1.5 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SAICAR_synt PF01259.13 KOO53856.1 - 2.6e-75 252.7 0.0 3.4e-75 252.3 0.0 1.1 1 0 0 1 1 1 1 SAICAR synthetase Dpy-30 PF05186.8 KOO53856.1 - 0.029 13.8 0.2 0.12 11.8 0.0 2.1 2 0 0 2 2 2 0 Dpy-30 motif Adenosine_kin PF04008.9 KOO53856.1 - 0.1 12.0 0.0 7.4 6.0 0.0 2.3 2 0 0 2 2 2 0 Adenosine specific kinase UBA PF00627.26 KOO53857.1 - 0.00058 19.6 0.3 0.0019 17.9 0.2 1.9 1 0 0 1 1 1 1 UBA/TS-N domain Herpes_UL3 PF03369.8 KOO53857.1 - 0.003 17.5 1.0 3 7.7 0.0 4.1 4 0 0 4 4 4 1 Herpesvirus UL3 protein UBA_4 PF14555.1 KOO53857.1 - 0.025 14.1 0.0 0.11 12.1 0.0 2.1 2 0 0 2 2 2 0 UBA-like domain HeH PF12949.2 KOO53857.1 - 0.069 12.7 0.4 34 4.1 0.0 3.7 4 0 0 4 4 4 0 HeH/LEM domain PTS_2-RNA PF01885.11 KOO53857.1 - 0.075 12.3 0.8 0.33 10.2 0.5 2.1 1 1 0 1 1 1 0 RNA 2'-phosphotransferase, Tpt1 / KptA family Cupin_8 PF13621.1 KOO53858.1 - 4.6e-32 111.4 0.0 6.3e-32 111.0 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 KOO53858.1 - 1.4e-09 37.6 0.1 2.3e-09 36.9 0.1 1.3 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.17 KOO53858.1 - 0.0041 17.3 0.0 0.012 15.8 0.0 1.8 1 1 0 1 1 1 1 JmjC domain, hydroxylase DUF4320 PF14208.1 KOO53859.1 - 8.3 6.4 10.5 0.5 10.3 1.5 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4320) Orai-1 PF07856.7 KOO53862.1 - 6.9e-07 28.9 7.7 5.8e-06 25.9 5.4 1.9 1 1 0 1 1 1 1 Mediator of CRAC channel activity NfeD PF01957.13 KOO53862.1 - 0.019 15.1 0.4 0.019 15.1 0.3 1.7 2 0 0 2 2 2 0 NfeD-like C-terminal, partner-binding RseC_MucC PF04246.7 KOO53862.1 - 0.5 9.9 3.8 1.1 8.7 2.6 1.5 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Ank_2 PF12796.2 KOO53863.1 - 7.3e-22 77.5 2.6 3.8e-12 46.3 0.2 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO53863.1 - 5.1e-15 54.4 6.6 0.00017 21.2 0.1 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.1 KOO53863.1 - 4.4e-13 49.0 2.7 2.6e-05 24.3 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO53863.1 - 4.6e-12 46.1 0.0 4.5e-08 33.3 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 KOO53863.1 - 5.4e-06 26.1 0.1 1.7 9.1 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Glyco_trans_1_2 PF13524.1 KOO53865.1 - 0.00029 21.0 0.0 0.00054 20.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 K_channel_TID PF07941.6 KOO53865.1 - 6.3 7.1 7.5 11 6.3 5.2 1.5 1 1 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain DUF1338 PF07063.8 KOO53866.1 - 0.056 12.4 0.1 0.5 9.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1338) TIG PF01833.19 KOO53869.1 - 6e-06 26.1 0.0 0.064 13.2 0.0 3.3 2 0 0 2 2 2 2 IPT/TIG domain Methyltransf_24 PF13578.1 KOO53870.1 - 3.6e-09 37.4 0.1 7.5e-09 36.3 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain SNF2_N PF00176.18 KOO53871.1 - 4e-22 78.3 0.0 1.1e-16 60.5 0.0 2.2 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.26 KOO53871.1 - 2.2e-06 27.4 0.0 4.7e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 KOO53871.1 - 0.034 13.6 0.0 0.065 12.7 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase FHA PF00498.21 KOO53872.1 - 1.2e-15 57.3 0.0 1.6e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 FHA domain JmjC PF02373.17 KOO53873.1 - 1.5e-15 57.4 0.1 2.8e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.1 KOO53873.1 - 1.5e-14 54.0 0.0 6.1e-14 52.1 0.0 1.9 1 1 0 1 1 1 1 Cupin-like domain Cupin_2 PF07883.6 KOO53873.1 - 0.055 12.9 0.0 0.75 9.3 0.0 2.6 3 0 0 3 3 3 0 Cupin domain Cupin_4 PF08007.7 KOO53873.1 - 0.072 12.3 0.7 0.29 10.3 0.5 2.1 1 1 0 1 1 1 0 Cupin superfamily protein DnaJ PF00226.26 KOO53875.1 - 2.4e-20 72.0 0.2 4.1e-20 71.2 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain Tmemb_185A PF10269.4 KOO53875.1 - 0.0088 15.6 0.1 0.013 15.1 0.1 1.2 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein Beach PF02138.13 KOO53876.1 - 4.5e-52 177.1 0.0 6.6e-52 176.5 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain VPS9 PF02204.13 KOO53876.1 - 3.5e-08 33.4 0.0 7.1e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain IQ PF00612.22 KOO53876.1 - 0.0038 16.7 0.0 0.011 15.3 0.0 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif tRNA-synt_1 PF00133.17 KOO53877.1 - 4.2e-109 365.2 0.0 2e-60 204.4 0.0 3.1 1 1 2 3 3 3 3 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 KOO53877.1 - 9.7e-18 64.3 0.0 1.6e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 KOO53877.1 - 9.3e-08 31.1 0.0 0.082 11.5 0.0 3.2 3 0 0 3 3 3 3 tRNA synthetases class I (M) WHEP-TRS PF00458.15 KOO53877.1 - 2.1e-07 30.4 2.1 4.3e-07 29.4 1.4 1.5 1 0 0 1 1 1 1 WHEP-TRS domain ABC1 PF03109.11 KOO53878.1 - 5.4e-24 84.4 0.0 9.8e-24 83.6 0.0 1.4 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 KOO53878.1 - 6.3e-07 29.3 1.2 6.3e-07 29.3 0.9 3.6 2 2 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.20 KOO53878.1 - 0.041 13.0 0.0 0.11 11.6 0.0 1.6 1 1 0 1 1 1 0 Protein kinase domain Pkinase_Tyr PF07714.12 KOO53878.1 - 0.11 11.5 0.0 0.3 10.0 0.0 1.6 2 0 0 2 2 2 0 Protein tyrosine kinase DUF1800 PF08811.6 KOO53880.1 - 1.3e-58 199.0 0.1 1e-32 113.7 0.1 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1800) DUF1501 PF07394.7 KOO53880.1 - 9e-40 136.7 0.1 1.9e-39 135.6 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1501) Acyl-CoA_dh_2 PF08028.6 KOO53881.1 - 0.36 11.0 5.6 0.13 12.4 1.2 2.3 1 1 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain Snf7 PF03357.16 KOO53882.1 - 1.2e-11 44.3 21.8 1.2e-11 44.2 14.8 1.3 1 1 0 1 1 1 1 Snf7 Anti-adapt_IraP PF10796.4 KOO53882.1 - 0.014 15.7 4.4 0.021 15.2 2.6 1.6 1 1 0 1 1 1 0 Sigma-S stabilisation anti-adaptor protein KxDL PF10241.4 KOO53882.1 - 0.047 13.5 1.8 0.067 13.0 0.9 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein WAPL PF07814.8 KOO53882.1 - 0.048 12.3 0.1 0.056 12.1 0.1 1.1 1 0 0 1 1 1 0 Wings apart-like protein regulation of heterochromatin Ribosomal_S21 PF01165.15 KOO53882.1 - 0.097 12.1 0.1 0.24 10.8 0.1 1.7 1 1 0 1 1 1 0 Ribosomal protein S21 DUF3349 PF11829.3 KOO53882.1 - 0.13 12.6 2.8 0.2 12.0 1.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3349) DUF3647 PF12363.3 KOO53882.1 - 0.78 9.8 5.4 1.3 9.1 3.7 1.5 1 1 0 1 1 1 0 Phage protein Methyltransf_18 PF12847.2 KOO53884.1 - 1.7e-07 31.7 0.1 0.00093 19.7 0.0 2.8 2 2 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.1 KOO53884.1 - 1e-06 28.6 0.0 0.034 13.8 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain PCMT PF01135.14 KOO53884.1 - 2.6e-05 23.8 0.4 0.024 14.1 0.1 2.2 2 0 0 2 2 2 2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.7 KOO53884.1 - 6.1e-05 23.4 0.2 0.018 15.4 0.1 2.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 KOO53884.1 - 7.9e-05 22.9 0.1 0.021 15.1 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 KOO53884.1 - 8e-05 22.6 1.4 0.04 13.9 0.2 3.1 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.1 KOO53884.1 - 8.1e-05 22.2 0.0 0.014 14.9 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.7 KOO53884.1 - 0.00028 21.3 0.4 0.24 11.8 0.0 3.6 4 0 0 4 4 4 1 Methyltransferase domain Methyltransf_24 PF13578.1 KOO53884.1 - 0.0047 17.7 0.2 2.5 8.9 0.1 2.6 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_3 PF01596.12 KOO53884.1 - 0.1 11.6 0.0 0.24 10.4 0.0 1.6 1 0 0 1 1 1 0 O-methyltransferase DEAD PF00270.24 KOO53886.1 - 4.3e-46 156.4 0.0 6.8e-46 155.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 KOO53886.1 - 5.7e-26 90.1 0.0 1.4e-25 88.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 KOO53886.1 - 0.016 15.0 0.0 0.036 13.8 0.0 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit CMS1 PF14617.1 KOO53886.1 - 0.081 11.9 0.0 0.56 9.2 0.0 2.1 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit DUF3235 PF11574.3 KOO53886.1 - 2.4 8.4 7.2 30 4.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3235) Porin_3 PF01459.17 KOO53888.1 - 9e-31 107.1 1.6 1.1e-30 106.8 1.1 1.0 1 0 0 1 1 1 1 Eukaryotic porin LRR_6 PF13516.1 KOO53889.1 - 3.4e-20 69.7 1.3 0.00037 20.2 0.0 6.3 6 0 0 6 6 6 4 Leucine Rich repeat CbiG_N PF11760.3 KOO53889.1 - 0.0043 16.7 5.1 8.5 6.1 0.0 4.3 3 1 1 4 4 4 2 Cobalamin synthesis G N-terminal SpoU_sub_bind PF08032.7 KOO53889.1 - 0.043 13.9 2.2 4.3 7.5 0.1 3.6 2 1 1 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding EIF_2_alpha PF07541.7 KOO53889.1 - 0.13 11.9 0.1 5.8 6.6 0.0 2.2 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 2 alpha subunit DndB PF14072.1 KOO53890.1 - 0.012 14.8 0.0 0.019 14.0 0.0 1.2 1 0 0 1 1 1 0 DNA-sulfur modification-associated DUF262 PF03235.9 KOO53890.1 - 0.22 11.4 0.0 0.35 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF262 EF-hand_1 PF00036.27 KOO53891.1 - 3.7e-14 50.8 1.0 3e-06 26.1 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.1 KOO53891.1 - 5.7e-13 47.5 3.1 2.8e-05 23.6 0.0 3.2 2 1 1 3 3 3 2 EF-hand domain EF-hand_5 PF13202.1 KOO53891.1 - 3.4e-09 35.6 0.7 0.00086 18.5 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.1 KOO53891.1 - 4.8e-09 35.6 0.0 0.0025 17.4 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.1 KOO53891.1 - 5.6e-09 36.0 0.8 0.0014 18.7 0.1 2.2 1 1 0 2 2 2 2 EF-hand domain pair EF-hand_10 PF14788.1 KOO53891.1 - 0.048 13.3 0.1 0.39 10.4 0.0 2.1 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.1 KOO53893.1 - 1.8e-10 39.7 0.2 0.00055 19.5 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.1 KOO53893.1 - 1e-07 30.9 0.0 0.0022 17.2 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.27 KOO53893.1 - 1.6e-07 30.1 0.0 0.0072 15.5 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 KOO53893.1 - 5.3e-07 29.6 0.0 0.041 14.0 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 KOO53893.1 - 6.9e-05 22.3 0.0 0.17 11.5 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair HD PF01966.17 KOO53894.1 - 5.8e-13 48.9 0.1 1.3e-12 47.7 0.0 1.7 1 0 0 1 1 1 1 HD domain zinc_ribbon_2 PF13240.1 KOO53894.1 - 0.00017 20.9 2.0 0.0004 19.7 1.4 1.6 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.2 KOO53894.1 - 0.00029 20.5 0.6 0.0007 19.3 0.5 1.6 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.1 KOO53894.1 - 0.00056 19.0 1.0 0.0012 17.9 0.7 1.6 1 0 0 1 1 1 1 zinc-ribbon domain Arm PF00514.18 KOO53895.1 - 5.4e-07 29.2 3.8 0.016 15.0 0.0 5.1 4 0 0 4 4 4 3 Armadillo/beta-catenin-like repeat INTS5_C PF14838.1 KOO53895.1 - 0.064 11.5 0.1 0.087 11.1 0.1 1.1 1 0 0 1 1 1 0 Integrator complex subunit 5 C-terminus EF-hand_7 PF13499.1 KOO53896.1 - 6.3e-19 67.8 1.1 3.4e-05 23.9 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.27 KOO53896.1 - 1.8e-13 48.7 4.0 1.8e-07 29.9 0.1 4.5 5 0 0 5 5 5 2 EF hand EF-hand_6 PF13405.1 KOO53896.1 - 4.4e-12 44.8 5.8 0.0017 18.0 0.1 5.1 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.1 KOO53896.1 - 3.3e-09 35.6 8.8 2.2e-05 23.5 0.2 3.4 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.1 KOO53896.1 - 1.8e-08 33.8 1.8 4.7e-06 26.1 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.4 KOO53896.1 - 1.3e-07 31.6 0.2 0.0043 17.0 0.0 3.5 3 0 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.2 KOO53896.1 - 0.00066 19.3 0.9 0.0028 17.3 0.0 2.3 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand bZIP_1 PF00170.16 KOO53896.1 - 0.046 13.6 1.5 0.17 11.8 1.0 1.9 1 0 0 1 1 1 0 bZIP transcription factor EF-hand_10 PF14788.1 KOO53896.1 - 0.093 12.4 1.1 3.6 7.3 0.1 3.3 4 0 0 4 4 4 0 EF hand IQ PF00612.22 KOO53896.1 - 0.22 11.2 3.7 1.1 9.0 2.6 2.3 1 0 0 1 1 1 0 IQ calmodulin-binding motif Abhydrolase_5 PF12695.2 KOO53897.1 - 2.5e-05 24.0 0.0 6.5e-05 22.7 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF229 PF02995.12 KOO53898.1 - 1.8e-33 115.7 0.0 2.2e-33 115.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF229) LigT_PEase PF02834.11 KOO53898.1 - 0.049 13.6 0.0 0.092 12.7 0.0 1.4 1 0 0 1 1 1 0 LigT like Phosphoesterase Ret_tiss PF10044.4 KOO53899.1 - 0.062 13.8 0.0 0.21 12.1 0.0 1.9 1 0 0 1 1 1 0 Retinal tissue protein FAM176 PF14851.1 KOO53899.1 - 0.29 10.8 6.5 2.7 7.6 4.5 2.1 2 0 0 2 2 2 0 FAM176 family PRTP PF01366.13 KOO53899.1 - 1 7.2 5.6 1.5 6.7 3.9 1.1 1 0 0 1 1 1 0 Herpesvirus processing and transport protein CENP-B_dimeris PF09026.5 KOO53899.1 - 1.2 9.3 8.8 32 4.8 4.7 2.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain CDC45 PF02724.9 KOO53899.1 - 1.9 6.4 9.7 2.5 6.0 6.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Pox_RNA_Pol_19 PF05320.7 KOO53899.1 - 5.8 6.6 7.7 11 5.6 5.3 1.4 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit LRR_5 PF13306.1 KOO53900.1 - 1.9e-127 418.8 0.0 6.2e-39 132.6 0.0 3.0 1 1 3 4 4 4 4 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO53900.1 - 8.1e-28 95.9 0.0 3.2e-06 26.7 0.0 6.1 1 1 5 6 6 6 6 Leucine rich repeat He_PIG PF05345.7 KOO53900.1 - 0.007 16.3 9.0 1.3e+02 2.7 0.0 7.4 8 0 0 8 8 8 0 Putative Ig domain Fork_head_N PF08430.7 KOO53900.1 - 0.2 12.0 17.7 2.7 8.3 4.2 3.2 1 1 1 2 2 2 0 Forkhead N-terminal region C1_3 PF07649.7 KOO53900.1 - 1.4 8.9 7.0 97 3.1 0.1 4.3 4 0 0 4 4 4 0 C1-like domain CPSase_L_chain PF00289.17 KOO53901.1 - 2.3e-20 72.7 0.1 3.1e-20 72.3 0.1 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain BSD PF03909.12 KOO53902.1 - 6.4e-18 64.2 0.0 4.4e-08 32.7 0.0 2.6 3 0 0 3 3 3 2 BSD domain DUF169 PF02596.10 KOO53902.1 - 0.037 13.4 0.1 1.1 8.6 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised ArCR, COG2043 LTXXQ PF07813.7 KOO53902.1 - 0.073 13.5 1.8 14 6.2 0.1 2.7 3 0 0 3 3 3 0 LTXXQ motif family protein YopE PF03545.8 KOO53903.1 - 0.017 15.0 0.1 0.27 11.1 0.0 2.5 2 1 1 3 3 3 0 Yersinia virulence determinant (YopE) Tyr-DNA_phospho PF06087.7 KOO53904.1 - 3.5e-21 75.3 0.0 1.3e-08 33.9 0.0 3.2 1 1 2 3 3 3 3 Tyrosyl-DNA phosphodiesterase DUF3437 PF11919.3 KOO53904.1 - 0.18 11.5 0.8 5.5 6.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) LRR_5 PF13306.1 KOO53905.1 - 1.6e-113 373.8 0.0 3.3e-40 136.7 0.0 3.4 1 1 2 3 3 3 3 Leucine rich repeats (6 copies) LRR_8 PF13855.1 KOO53905.1 - 7.7e-38 128.0 0.0 9.5e-06 25.2 0.0 7.7 2 1 6 8 8 8 7 Leucine rich repeat CBFB_NFYA PF02045.10 KOO53906.1 - 1.8e-16 60.3 8.4 2.5e-16 59.9 5.8 1.2 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Pribosyltran PF00156.22 KOO53908.1 - 6e-16 58.2 0.0 7.9e-16 57.9 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.1 KOO53908.1 - 0.064 12.5 0.0 0.091 12.0 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase UPRTase PF14681.1 KOO53908.1 - 0.13 11.4 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase zf-LITAF-like PF10601.4 KOO53909.1 - 2.9 7.8 4.9 12 5.8 0.1 3.6 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain Pil1 PF13805.1 KOO53910.1 - 5.5 6.0 5.7 5.3 6.0 3.9 1.0 1 0 0 1 1 1 0 Eisosome component PIL1 Ank_2 PF12796.2 KOO53911.1 - 9.3e-23 80.3 6.8 3.1e-11 43.4 0.7 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 KOO53911.1 - 1.1e-19 69.1 7.0 5.9e-06 25.8 0.0 4.5 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.1 KOO53911.1 - 2.4e-15 55.1 1.3 0.00012 21.9 0.0 4.5 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.1 KOO53911.1 - 4.5e-14 52.1 6.6 4.2e-06 26.8 0.1 4.6 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 KOO53911.1 - 2.6e-13 50.0 1.2 8.5e-07 29.3 0.2 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) GATase_2 PF00310.16 KOO53914.1 - 0.081 11.6 0.0 0.14 10.8 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferases class-II SseC PF04888.7 KOO53914.1 - 0.3 10.3 0.3 0.5 9.6 0.2 1.2 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Biotin_lipoyl PF00364.17 KOO53915.1 - 3.3e-14 52.2 0.0 3.9e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Biotin-requiring enzyme Amino_oxidase PF01593.19 KOO53916.1 - 1.6e-54 185.7 2.1 5.8e-52 177.2 1.5 2.1 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 KOO53916.1 - 4.5e-13 49.0 0.1 1.2e-12 47.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 KOO53916.1 - 1.3e-07 30.9 7.9 2.6e-06 26.5 5.5 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 KOO53916.1 - 2.5e-07 30.0 0.4 3.9e-07 29.4 0.3 1.2 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.19 KOO53916.1 - 3e-07 29.6 2.5 3e-07 29.6 1.7 2.4 3 0 0 3 3 2 1 FAD binding domain Pyr_redox_3 PF13738.1 KOO53916.1 - 3.3e-07 30.5 0.1 1.7e-05 24.9 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 KOO53916.1 - 3.6e-07 29.0 0.5 6.1e-07 28.2 0.3 1.4 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.22 KOO53916.1 - 3e-06 27.5 0.1 8.6e-06 26.0 0.1 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 KOO53916.1 - 1.4e-05 24.3 1.2 1.4e-05 24.3 0.8 1.8 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.2 KOO53916.1 - 0.00011 21.3 1.0 0.00022 20.4 0.7 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 KOO53916.1 - 0.00012 22.0 0.0 0.00021 21.2 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 KOO53916.1 - 0.00018 20.5 1.3 0.001 18.0 0.4 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_9 PF13454.1 KOO53916.1 - 0.0014 18.4 0.3 0.013 15.2 0.0 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding FMO-like PF00743.14 KOO53916.1 - 0.0019 16.5 0.0 0.0025 16.0 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like GIDA PF01134.17 KOO53916.1 - 0.0021 16.9 0.5 0.0036 16.2 0.4 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A 3HCDH_N PF02737.13 KOO53916.1 - 0.015 14.9 0.3 0.028 14.0 0.2 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.7 KOO53916.1 - 0.043 13.1 0.1 0.069 12.5 0.1 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain AlaDh_PNT_C PF01262.16 KOO53916.1 - 0.087 12.3 0.5 0.15 11.6 0.4 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.13 KOO53916.1 - 0.15 12.0 0.1 0.36 10.8 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain