# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- CesT PF05932.8 CDF87163.1 - 0.077 12.8 0.0 0.15 11.9 0.0 1.4 1 1 0 1 1 1 0 Tir chaperone protein (CesT) family ADH_N PF08240.7 CDF87166.1 - 3.7e-28 97.4 3.1 3.7e-28 97.4 2.2 2.3 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CDF87166.1 - 2.1e-21 75.8 0.3 3.7e-21 75.0 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 CDF87166.1 - 0.00094 18.3 0.2 0.0015 17.6 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 CDF87166.1 - 0.0016 17.8 0.0 0.0027 17.1 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.13 CDF87166.1 - 0.0017 18.3 0.0 0.0031 17.4 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain ELFV_dehydrog PF00208.16 CDF87166.1 - 0.019 14.5 0.4 0.033 13.7 0.2 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NADH_4Fe-4S PF10589.4 CDF87166.1 - 0.027 13.6 1.3 0.076 12.1 0.9 1.7 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Pyr_redox PF00070.22 CDF87166.1 - 0.054 13.9 0.0 0.44 10.9 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 CDF87166.1 - 0.062 12.9 0.1 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.1 CDF87166.1 - 0.089 12.8 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.16 CDF87166.1 - 0.11 12.3 0.1 0.36 10.6 0.0 1.9 2 0 0 2 2 2 0 ThiF family AlaDh_PNT_C PF01262.16 CDF87166.1 - 0.19 11.2 2.4 0.24 10.9 0.2 2.0 2 1 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_1 PF00667.15 CDF87167.1 - 9.9e-65 218.0 0.0 2.2e-64 216.8 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 CDF87167.1 - 6.8e-24 84.4 0.2 1.4e-23 83.4 0.1 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 CDF87167.1 - 8.7e-21 74.5 0.4 5.1e-20 72.0 0.1 2.4 3 0 0 3 3 3 1 Oxidoreductase NAD-binding domain Spore_IV_A PF09547.5 CDF87167.1 - 0.013 14.2 0.0 0.021 13.5 0.0 1.2 1 0 0 1 1 1 0 Stage IV sporulation protein A (spore_IV_A) Flavodoxin_5 PF12724.2 CDF87167.1 - 0.022 14.7 0.0 0.092 12.7 0.0 2.1 2 0 0 2 2 2 0 Flavodoxin domain tRNA_Me_trans PF03054.11 CDF87167.1 - 0.092 11.2 0.1 0.18 10.3 0.0 1.4 1 0 0 1 1 1 0 tRNA methyl transferase Esterase PF00756.15 CDF87168.1 - 6.8e-59 199.3 0.0 7.9e-59 199.1 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Abhydrolase_5 PF12695.2 CDF87168.1 - 5e-05 23.0 0.0 7.8e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 CDF87168.1 - 0.009 14.9 0.0 0.013 14.3 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Peptidase_S9 PF00326.16 CDF87168.1 - 0.0097 15.1 0.0 0.014 14.5 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Lipase_3 PF01764.20 CDF87168.1 - 0.017 14.7 0.0 0.03 13.9 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Esterase_phd PF10503.4 CDF87168.1 - 0.073 12.3 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Esterase PHB depolymerase FMN_dh PF01070.13 CDF87169.1 - 1.2e-83 280.9 0.0 4.3e-83 279.1 0.0 1.8 1 1 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.23 CDF87169.1 - 1.3e-20 72.9 0.0 2.7e-20 71.9 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.12 CDF87169.1 - 2.1e-08 33.5 0.1 4.6e-08 32.3 0.0 1.6 2 0 0 2 2 2 1 Conserved region in glutamate synthase IMPDH PF00478.20 CDF87169.1 - 0.0083 15.0 2.1 0.03 13.2 0.1 2.5 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain AA_permease PF00324.16 CDF87170.1 - 7.9e-105 350.9 34.4 9e-105 350.7 23.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CDF87170.1 - 9.9e-32 110.0 37.4 1.3e-31 109.5 25.9 1.1 1 0 0 1 1 1 1 Amino acid permease Fungal_trans_2 PF11951.3 CDF87171.1 - 1.5e-40 139.0 2.0 1.8e-40 138.7 1.4 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF87171.1 - 1.1e-05 25.1 7.4 2.2e-05 24.2 5.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aminotran_3 PF00202.16 CDF87172.1 - 9.2e-59 198.9 0.0 1.1e-58 198.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III DHO_dh PF01180.16 CDF87174.1 - 7.8e-87 290.9 0.0 8.8e-87 290.7 0.0 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.13 CDF87174.1 - 4.7e-06 25.6 0.0 0.00011 21.2 0.0 2.1 2 0 0 2 2 2 1 FMN-dependent dehydrogenase Polysacc_deac_1 PF01522.16 CDF87174.1 - 0.038 13.6 0.0 0.17 11.5 0.0 1.9 2 1 0 2 2 2 0 Polysaccharide deacetylase NMO PF03060.10 CDF87174.1 - 0.11 11.6 0.1 0.21 10.6 0.1 1.4 1 0 0 1 1 1 0 Nitronate monooxygenase SSF PF00474.12 CDF87175.1 - 1.5e-20 73.2 23.6 2.4e-20 72.5 16.4 1.4 1 0 0 1 1 1 1 Sodium:solute symporter family DUF2207 PF09972.4 CDF87175.1 - 0.0034 16.0 0.0 0.0034 16.0 0.0 3.2 2 1 1 3 3 3 1 Predicted membrane protein (DUF2207) Adaptin_binding PF10199.4 CDF87175.1 - 0.035 14.3 5.4 0.055 13.7 3.8 1.2 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Glyco_tran_28_C PF04101.11 CDF87178.1 - 4e-29 101.4 0.0 2.2e-28 99.0 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.1 CDF87178.1 - 0.00086 18.5 0.0 0.0011 18.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 1 AAA PF00004.24 CDF87179.1 - 4.5e-43 146.6 0.0 8.1e-43 145.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CDF87179.1 - 9.5e-07 28.6 0.0 3.8e-06 26.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 CDF87179.1 - 1.4e-06 28.3 0.0 3.2e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 CDF87179.1 - 3.7e-06 27.1 0.1 0.00029 20.9 0.0 2.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDF87179.1 - 2.8e-05 24.1 0.0 0.00016 21.7 0.0 1.8 1 1 1 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 CDF87179.1 - 3.6e-05 24.5 0.2 0.00013 22.7 0.0 2.1 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.7 CDF87179.1 - 0.00013 21.1 0.0 0.00022 20.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 CDF87179.1 - 0.00018 21.1 0.1 0.00041 20.0 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain IstB_IS21 PF01695.12 CDF87179.1 - 0.0002 20.8 0.0 0.00035 20.0 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.1 CDF87179.1 - 0.00076 19.3 0.0 0.0015 18.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 CDF87179.1 - 0.0018 18.2 0.0 0.0036 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CDF87179.1 - 0.0018 18.1 0.0 0.004 17.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 CDF87179.1 - 0.0038 16.3 0.0 0.0096 15.0 0.0 1.7 1 0 0 1 1 1 1 Zeta toxin DUF2072 PF09845.4 CDF87179.1 - 0.0052 16.7 1.3 0.012 15.5 0.9 1.6 1 0 0 1 1 1 1 Zn-ribbon containing protein (DUF2072) AAA_3 PF07726.6 CDF87179.1 - 0.0058 16.2 0.0 0.015 14.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 CDF87179.1 - 0.0079 16.5 1.7 0.032 14.5 0.0 2.7 3 1 0 3 3 3 1 AAA domain TIP49 PF06068.8 CDF87179.1 - 0.01 14.5 0.0 0.023 13.3 0.0 1.6 1 0 0 1 1 1 0 TIP49 C-terminus PhoH PF02562.11 CDF87179.1 - 0.013 14.7 0.0 0.046 12.9 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein Mg_chelatase PF01078.16 CDF87179.1 - 0.015 14.4 0.1 0.035 13.2 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 CDF87179.1 - 0.029 13.7 0.1 0.1 11.9 0.0 1.8 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.1 CDF87179.1 - 0.03 13.9 0.0 0.057 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 CDF87179.1 - 0.031 13.7 0.0 0.15 11.5 0.0 2.1 3 0 0 3 3 3 0 Sigma-54 interaction domain NB-ARC PF00931.17 CDF87179.1 - 0.044 12.6 0.0 0.09 11.6 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.17 CDF87179.1 - 0.048 13.8 0.0 0.097 12.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase DUF815 PF05673.8 CDF87179.1 - 0.054 12.4 0.0 0.12 11.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NACHT PF05729.7 CDF87179.1 - 0.062 12.9 0.0 0.35 10.4 0.0 2.0 1 1 1 2 2 2 0 NACHT domain Tropomyosin PF00261.15 CDF87179.1 - 0.071 12.1 3.3 0.079 12.0 0.5 2.0 2 0 0 2 2 2 0 Tropomyosin Parvo_NS1 PF01057.12 CDF87179.1 - 0.079 11.8 0.0 0.13 11.0 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 MIF4G PF02854.14 CDF87180.1 - 1.7e-46 158.2 0.2 3.8e-46 157.1 0.1 1.6 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.3 CDF87180.1 - 1.4e-28 98.6 0.5 7.2e-28 96.3 0.3 2.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 TYW3 PF02676.9 CDF87181.1 - 4.7e-64 215.3 0.0 5.4e-64 215.1 0.0 1.0 1 0 0 1 1 1 1 Methyltransferase TYW3 Gtr1_RagA PF04670.7 CDF87182.1 - 3.3e-66 222.7 0.6 4.3e-66 222.3 0.4 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.16 CDF87182.1 - 0.0004 19.6 0.1 0.0015 17.7 0.0 2.0 2 0 0 2 2 2 1 ADP-ribosylation factor family SRPRB PF09439.5 CDF87182.1 - 0.016 14.3 0.1 0.038 13.2 0.0 1.6 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.1 CDF87182.1 - 0.031 14.1 0.0 0.071 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain GTP_cyclohydro2 PF00925.15 CDF87182.1 - 0.081 12.1 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 GTP cyclohydrolase II DUF3336 PF11815.3 CDF87183.1 - 1.9e-39 134.4 5.1 4.3e-39 133.3 3.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.17 CDF87183.1 - 1.5e-29 103.4 0.0 2.7e-29 102.5 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase DUF4610 PF15384.1 CDF87183.1 - 0.0064 16.0 0.2 0.015 14.8 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4610) F-box-like PF12937.2 CDF87184.1 - 4.5e-08 32.6 0.3 1e-07 31.5 0.2 1.7 1 0 0 1 1 1 1 F-box-like TPR_11 PF13414.1 CDF87184.1 - 9.7e-08 31.5 2.2 0.0093 15.5 0.0 2.5 2 0 0 2 2 2 2 TPR repeat F-box PF00646.28 CDF87184.1 - 2.2e-06 27.1 0.1 7.3e-06 25.5 0.1 1.9 1 0 0 1 1 1 1 F-box domain TPR_16 PF13432.1 CDF87184.1 - 5e-06 27.0 0.8 0.0027 18.3 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 CDF87184.1 - 4.8e-05 22.7 5.7 0.35 10.5 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.12 CDF87184.1 - 5.3e-05 22.8 8.2 0.019 14.8 0.4 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 CDF87184.1 - 7.1e-05 22.6 6.5 0.0083 16.0 0.1 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat Apc3 PF12895.2 CDF87184.1 - 0.00068 19.7 1.1 1.2 9.3 0.1 2.6 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.1 CDF87184.1 - 0.0012 18.7 3.8 0.1 12.5 0.2 3.0 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat LRR_4 PF12799.2 CDF87184.1 - 0.0013 18.2 10.3 0.62 9.7 0.1 4.9 6 0 0 6 6 5 2 Leucine Rich repeats (2 copies) NARP1 PF12569.3 CDF87184.1 - 0.0035 16.1 0.0 0.0075 15.0 0.0 1.5 1 0 0 1 1 1 1 NMDA receptor-regulated protein 1 TPR_7 PF13176.1 CDF87184.1 - 0.0055 16.4 3.0 0.39 10.6 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 CDF87184.1 - 0.0081 16.4 0.3 1.1 9.6 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.1 CDF87184.1 - 0.0097 16.4 0.4 1.6 9.5 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat Death PF00531.17 CDF87184.1 - 0.043 13.5 0.2 1.1 9.0 0.1 2.7 2 0 0 2 2 2 0 Death domain TPR_10 PF13374.1 CDF87184.1 - 1 9.3 3.0 1 9.3 0.1 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat LRR_7 PF13504.1 CDF87184.1 - 1.2 9.5 11.1 56 4.6 0.0 7.0 8 2 0 8 8 7 0 Leucine rich repeat LRR_6 PF13516.1 CDF87184.1 - 7.8 6.9 9.2 26 5.3 0.2 5.1 6 0 0 6 6 4 0 Leucine Rich repeat Zip PF02535.17 CDF87185.1 - 1.2e-24 86.9 19.4 2.7e-17 62.7 6.6 2.1 1 1 1 2 2 2 2 ZIP Zinc transporter Melittin PF01372.12 CDF87185.1 - 0.78 9.1 2.8 1.8 8.0 2.0 1.5 1 0 0 1 1 1 0 Melittin U3_snoRNA_assoc PF08297.6 CDF87186.1 - 3.1e-15 56.1 7.0 3.1e-15 56.1 4.9 2.3 2 0 0 2 2 2 1 U3 snoRNA associated Selenoprotein_S PF06936.6 CDF87186.1 - 0.14 11.6 10.9 0.22 11.0 7.5 1.2 1 0 0 1 1 1 0 Selenoprotein S (SelS) adh_short_C2 PF13561.1 CDF87187.1 - 2.2e-27 96.3 0.1 2.9e-27 96.0 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CDF87187.1 - 3.6e-23 82.3 0.5 4.7e-23 81.9 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CDF87187.1 - 1.7e-07 31.1 0.5 4e-07 29.8 0.3 1.8 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 CDF87187.1 - 0.0014 18.1 0.2 0.0036 16.7 0.1 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CDF87187.1 - 0.021 14.8 0.5 0.094 12.7 0.3 2.1 1 1 0 1 1 1 0 NADH(P)-binding Autotrns_rpt PF12951.2 CDF87187.1 - 0.033 13.8 0.3 9.5 6.0 0.2 2.3 2 0 0 2 2 2 0 Autotransporter-associated beta strand repeat Pyr_redox_2 PF07992.9 CDF87187.1 - 0.058 13.2 0.1 0.088 12.6 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.11 CDF87187.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA PuR_N PF09182.5 CDF87187.1 - 0.18 11.4 0.5 1.1 8.9 0.1 2.2 2 0 0 2 2 2 0 Bacterial purine repressor, N-terminal SNARE_assoc PF09335.6 CDF87188.1 - 7.1e-14 52.0 9.1 7.1e-14 52.0 6.3 2.8 2 1 1 3 3 3 1 SNARE associated Golgi protein DUF1049 PF06305.6 CDF87188.1 - 0.01 15.3 0.1 0.01 15.3 0.1 3.7 3 1 1 4 4 4 1 Protein of unknown function (DUF1049) P5-ATPase PF12409.3 CDF87188.1 - 0.081 12.7 0.8 0.48 10.2 0.2 2.3 2 0 0 2 2 2 0 P5-type ATPase cation transporter DUF4231 PF14015.1 CDF87188.1 - 0.32 11.0 8.8 7.3 6.6 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) Cg6151-P PF10233.4 CDF87188.1 - 0.36 10.8 4.8 0.78 9.7 0.3 2.8 3 1 0 3 3 3 0 Uncharacterized conserved protein CG6151-P Kin17_mid PF10357.4 CDF87189.1 - 4.6e-38 129.7 4.6 4.6e-38 129.7 3.2 1.8 2 1 0 2 2 2 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.3 CDF87189.1 - 1.1e-06 28.6 3.5 3e-06 27.2 2.4 1.8 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CDF87189.1 - 0.00012 22.1 5.3 0.00031 20.8 2.7 2.3 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 CDF87189.1 - 0.0031 17.5 0.7 0.0031 17.5 0.5 2.5 2 1 0 2 2 2 1 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.7 CDF87189.1 - 0.0098 15.6 4.3 0.0098 15.6 3.0 2.2 2 1 0 2 2 2 1 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_4 PF13894.1 CDF87189.1 - 4.5 7.8 8.5 1.9 9.0 1.9 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger HA2 PF04408.18 CDF87190.1 - 1.7e-23 82.5 0.0 6e-23 80.8 0.0 2.0 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 CDF87190.1 - 4.6e-23 81.2 0.0 1.3e-22 79.8 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 CDF87190.1 - 4.3e-16 58.5 0.0 1.1e-15 57.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 CDF87190.1 - 7.8e-08 32.5 0.2 2.4e-07 30.9 0.1 1.8 1 0 0 1 1 1 1 AAA domain T2SE PF00437.15 CDF87190.1 - 4.3e-05 22.5 0.1 0.0001 21.3 0.1 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein DEAD PF00270.24 CDF87190.1 - 9.3e-05 21.9 3.4 0.0001 21.8 0.8 2.2 2 1 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.10 CDF87190.1 - 0.0027 17.5 1.9 0.34 10.6 0.3 3.4 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 CDF87190.1 - 0.0068 16.1 0.1 0.017 14.8 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_14 PF13173.1 CDF87190.1 - 0.0083 16.0 0.2 0.16 11.8 0.2 2.6 1 1 0 1 1 1 1 AAA domain SRP54 PF00448.17 CDF87190.1 - 0.018 14.4 0.1 0.052 12.9 0.0 1.8 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain DUF2075 PF09848.4 CDF87190.1 - 0.02 13.9 0.0 0.035 13.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_29 PF13555.1 CDF87190.1 - 0.036 13.6 0.0 0.081 12.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Flavi_DEAD PF07652.9 CDF87190.1 - 0.041 13.6 0.1 0.084 12.6 0.1 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain PhoH PF02562.11 CDF87190.1 - 0.047 12.9 0.1 0.16 11.1 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_30 PF13604.1 CDF87190.1 - 0.054 13.0 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Herpes_ori_bp PF02399.10 CDF87190.1 - 0.13 10.1 0.0 0.21 9.5 0.0 1.2 1 0 0 1 1 1 0 Origin of replication binding protein AAA_23 PF13476.1 CDF87190.1 - 0.14 12.5 0.0 0.14 12.5 0.0 3.6 4 1 0 4 4 3 0 AAA domain MRP-L20 PF12824.2 CDF87191.1 - 4.1e-48 163.4 0.5 5e-48 163.1 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Frankia_peptide PF14407.1 CDF87191.1 - 0.00097 18.8 0.0 0.0017 18.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. CENP-B_N PF04218.8 CDF87191.1 - 0.023 14.1 0.1 0.12 11.8 0.0 2.1 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain DUF3348 PF11828.3 CDF87192.1 - 0.11 11.9 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3348) GTP_EFTU PF00009.22 CDF87193.1 - 1.9e-42 144.8 0.0 3.1e-42 144.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.5 CDF87193.1 - 5.1e-12 45.7 7.2 1.1e-11 44.6 5.0 1.6 1 0 0 1 1 1 1 HBS1 N-terminus MMR_HSR1 PF01926.18 CDF87193.1 - 4e-07 29.9 0.0 1.9e-05 24.5 0.0 2.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CDF87193.1 - 0.00046 20.6 0.0 0.023 15.1 0.0 2.8 1 1 0 1 1 1 1 Miro-like protein GTP_EFTU_D4 PF14578.1 CDF87193.1 - 0.00078 19.0 0.4 0.0022 17.5 0.3 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 4 GTP_EFTU_D2 PF03144.20 CDF87193.1 - 0.00087 19.3 0.3 0.0052 16.8 0.1 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.12 CDF87193.1 - 0.045 13.9 0.0 0.15 12.2 0.0 2.0 2 0 0 2 2 2 0 Elongation factor Tu C-terminal domain Ras PF00071.17 CDF87193.1 - 0.051 12.9 0.0 0.72 9.2 0.0 2.3 2 0 0 2 2 2 0 Ras family MobB PF03205.9 CDF87193.1 - 0.11 12.2 1.0 0.31 10.7 0.0 2.3 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B Dabb PF07876.7 CDF87193.1 - 0.16 12.4 1.3 23 5.5 0.0 2.9 3 0 0 3 3 3 0 Stress responsive A/B Barrel Domain Syntaxin-18_N PF10496.4 CDF87194.1 - 5e-14 51.8 5.6 1.5e-13 50.3 0.4 2.7 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus Cluap1 PF10234.4 CDF87194.1 - 6.5e-05 22.2 3.7 6.5e-05 22.2 2.6 2.4 2 0 0 2 2 2 2 Clusterin-associated protein-1 DUF2120 PF09893.4 CDF87194.1 - 8e-05 22.6 1.0 8e-05 22.6 0.7 2.3 2 2 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2120) SNARE PF05739.14 CDF87194.1 - 9.7e-05 21.9 7.1 9.7e-05 21.9 4.9 2.2 3 0 0 3 3 3 1 SNARE domain DUF948 PF06103.6 CDF87194.1 - 3.6 7.5 9.8 5.1 7.0 3.9 2.9 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Thymidylat_synt PF00303.14 CDF87195.1 - 6.5e-119 395.8 0.0 7.4e-119 395.6 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase Shugoshin_N PF07558.6 CDF87196.1 - 1.7e-14 53.2 2.9 1.7e-14 53.2 2.0 2.7 2 0 0 2 2 2 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.6 CDF87196.1 - 2.3e-11 42.9 2.5 1.1e-10 40.8 1.7 2.2 1 0 0 1 1 1 1 Shugoshin C terminus CHZ PF09649.5 CDF87196.1 - 0.004 16.3 0.4 0.012 14.7 0.3 1.8 1 0 0 1 1 1 1 Histone chaperone domain CHZ DASH_Dad2 PF08654.5 CDF87197.1 - 7.5e-31 106.1 1.5 8.7e-31 105.9 1.0 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad2 DASH_Duo1 PF08651.5 CDF87197.1 - 6.9e-06 25.5 1.9 1.1e-05 24.9 1.3 1.3 1 0 0 1 1 1 1 DASH complex subunit Duo1 Phage_GP20 PF06810.6 CDF87197.1 - 0.0031 16.9 1.3 0.0044 16.4 0.9 1.2 1 0 0 1 1 1 1 Phage minor structural protein GP20 MCPsignal PF00015.16 CDF87197.1 - 0.005 16.4 0.5 0.006 16.1 0.3 1.1 1 0 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain Mito_fiss_reg PF05308.6 CDF87197.1 - 0.012 14.9 0.1 0.013 14.9 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator PilJ PF13675.1 CDF87197.1 - 0.022 15.0 0.6 0.029 14.7 0.4 1.2 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term Laminin_II PF06009.7 CDF87197.1 - 0.023 14.4 1.0 0.028 14.1 0.7 1.2 1 0 0 1 1 1 0 Laminin Domain II CesA PF11439.3 CDF87197.1 - 0.058 13.3 0.3 0.082 12.8 0.2 1.2 1 0 0 1 1 1 0 Type III secretion system filament chaperone CesA Syntaxin PF00804.20 CDF87197.1 - 0.064 13.4 0.5 0.08 13.1 0.4 1.3 1 0 0 1 1 1 0 Syntaxin MscS_porin PF12795.2 CDF87197.1 - 0.065 12.5 4.0 0.083 12.2 2.8 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain YlbD_coat PF14071.1 CDF87197.1 - 0.11 12.5 1.7 0.17 11.9 1.2 1.3 1 0 0 1 1 1 0 Putative coat protein Reo_sigmaC PF04582.7 CDF87197.1 - 0.12 11.5 0.2 0.13 11.3 0.1 1.0 1 0 0 1 1 1 0 Reovirus sigma C capsid protein MCC-bdg_PDZ PF10506.4 CDF87197.1 - 0.13 12.1 2.1 0.19 11.6 1.4 1.3 1 0 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Frigida PF07899.6 CDF87197.1 - 0.13 10.9 1.6 0.18 10.5 1.1 1.1 1 0 0 1 1 1 0 Frigida-like protein FlxA PF14282.1 CDF87197.1 - 0.15 11.9 2.4 0.26 11.2 1.7 1.4 1 0 0 1 1 1 0 FlxA-like protein FliT PF05400.8 CDF87197.1 - 0.25 11.7 3.2 0.4 11.1 2.2 1.4 1 0 0 1 1 1 0 Flagellar protein FliT Med7 PF05983.6 CDF87197.1 - 0.51 10.0 5.0 6.1 6.5 0.1 2.1 1 1 1 2 2 2 0 MED7 protein Nucleoporin_C PF03177.9 CDF87198.1 - 3.6e-67 227.2 25.1 5.3e-67 226.6 17.4 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.6 CDF87198.1 - 5.6e-56 190.0 3.4 9.9e-56 189.2 2.4 1.3 1 0 0 1 1 1 1 Nup133 N terminal like Brix PF04427.13 CDF87199.1 - 1.6e-37 129.0 0.3 2.4e-37 128.4 0.2 1.3 1 0 0 1 1 1 1 Brix domain DUF4611 PF15387.1 CDF87199.1 - 0.013 15.6 4.5 0.03 14.4 3.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) THF_DHG_CYH_C PF02882.14 CDF87200.1 - 4.5e-18 64.8 0.0 2.3e-10 39.7 0.0 2.7 2 1 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.18 CDF87200.1 - 1.1e-16 60.9 0.1 3.5e-16 59.2 0.0 1.9 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Shikimate_DH PF01488.15 CDF87200.1 - 0.047 13.7 0.0 0.35 10.9 0.0 2.1 1 1 1 2 2 2 0 Shikimate / quinate 5-dehydrogenase RabGAP-TBC PF00566.13 CDF87201.1 - 2.8e-49 167.4 3.0 6.2e-49 166.3 2.1 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Lactamase_B_2 PF12706.2 CDF87202.1 - 2.7e-39 134.7 1.1 4.4e-39 134.0 0.7 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.1 CDF87202.1 - 7.6e-24 82.9 0.0 1.6e-23 81.9 0.0 1.6 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B PF00753.22 CDF87202.1 - 0.038 13.6 0.3 0.093 12.3 0.2 1.6 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily Vps5 PF09325.5 CDF87203.1 - 3.2e-72 242.5 15.6 6e-72 241.7 10.8 1.5 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.19 CDF87203.1 - 4.2e-22 78.0 0.9 1.7e-21 76.1 0.1 2.4 3 0 0 3 3 3 1 PX domain BAR_3_WASP_bdg PF10456.4 CDF87203.1 - 0.0086 15.3 1.7 0.018 14.3 1.2 1.5 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein Arfaptin PF06456.8 CDF87203.1 - 0.072 12.4 6.3 0.27 10.5 0.8 2.5 2 0 0 2 2 2 0 Arfaptin-like domain Prefoldin PF02996.12 CDF87203.1 - 0.23 11.0 5.7 11 5.6 0.3 3.5 2 1 1 3 3 3 0 Prefoldin subunit Occludin_ELL PF07303.8 CDF87203.1 - 0.82 10.4 10.3 3.3 8.4 0.3 3.2 3 0 0 3 3 3 0 Occludin homology domain Uds1 PF15456.1 CDF87203.1 - 5.5 6.9 14.9 0.23 11.4 0.2 3.9 3 1 0 3 3 3 0 Up-regulated During Septation Alg6_Alg8 PF03155.10 CDF87204.1 - 1.7e-152 508.5 45.3 2e-152 508.3 31.4 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family SprA-related PF12118.3 CDF87205.1 - 1.1e-05 24.9 21.6 1.1e-05 24.9 15.0 1.6 2 0 0 2 2 2 1 SprA-related family PAT1 PF09770.4 CDF87205.1 - 0.0034 15.7 30.5 0.008 14.4 21.2 1.7 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Suf PF05843.9 CDF87205.1 - 0.0039 16.9 18.2 0.0078 15.9 12.6 1.4 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) Zip PF02535.17 CDF87205.1 - 0.055 12.4 5.0 0.082 11.8 3.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CDK5_activator PF03261.10 CDF87205.1 - 0.1 11.8 10.5 0.23 10.7 7.3 1.5 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Ycf1 PF05758.7 CDF87205.1 - 0.11 10.1 9.2 0.17 9.5 6.4 1.2 1 0 0 1 1 1 0 Ycf1 Band_3_cyto PF07565.8 CDF87205.1 - 0.2 11.1 10.9 0.33 10.4 7.5 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Dicty_REP PF05086.7 CDF87205.1 - 0.24 9.0 9.9 0.33 8.6 6.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein TFIIA PF03153.8 CDF87205.1 - 0.27 11.1 27.1 0.052 13.4 15.6 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit LMBR1 PF04791.11 CDF87205.1 - 1.1 7.7 3.2 1.5 7.3 2.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Ndc1_Nup PF09531.5 CDF87205.1 - 1.6 7.0 11.5 2.9 6.2 8.0 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Spore_coat_CotO PF14153.1 CDF87205.1 - 1.7 8.0 23.3 0.64 9.4 14.2 1.7 2 0 0 2 2 2 0 Spore coat protein CotO RR_TM4-6 PF06459.7 CDF87205.1 - 2.3 8.0 15.4 4.5 7.0 10.7 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 AAA_23 PF13476.1 CDF87205.1 - 3.7 7.8 15.3 5.9 7.1 10.6 1.2 1 0 0 1 1 1 0 AAA domain DUF4175 PF13779.1 CDF87205.1 - 3.8 5.1 38.6 5.2 4.6 26.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Raftlin PF15250.1 CDF87205.1 - 7.9 4.8 18.0 62 1.9 12.0 2.2 2 0 0 2 2 2 0 Raftlin GST_N_2 PF13409.1 CDF87206.1 - 4.2e-22 77.9 0.0 1e-21 76.6 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 CDF87206.1 - 1.6e-10 40.7 0.0 4e-10 39.4 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 CDF87206.1 - 3.4e-05 23.7 0.0 8.4e-05 22.4 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 CDF87206.1 - 0.00044 20.4 0.1 0.47 10.7 0.0 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain Cytochrom_C1 PF02167.10 CDF87207.1 - 1.2e-82 276.7 0.0 1.5e-82 276.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.1 CDF87207.1 - 0.00026 21.0 0.1 0.00052 20.1 0.0 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.16 CDF87207.1 - 0.0023 18.7 0.7 0.0054 17.5 0.3 1.9 2 1 0 2 2 2 1 Cytochrome c Ras PF00071.17 CDF87208.1 - 1e-54 184.2 0.0 1.2e-54 184.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDF87208.1 - 5.8e-16 59.0 0.0 9.4e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDF87208.1 - 5.7e-07 28.9 0.0 8e-07 28.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 CDF87208.1 - 0.0022 17.4 0.0 0.0098 15.3 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 CDF87208.1 - 0.015 14.4 0.0 0.019 14.1 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.5 CDF87208.1 - 0.081 12.1 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Hom_end_hint PF05203.11 CDF87209.1 - 0.014 15.1 0.6 2.6 7.6 0.0 2.4 2 0 0 2 2 2 0 Hom_end-associated Hint Fmp27 PF10344.4 CDF87210.1 - 2.6e-113 379.5 19.9 2.6e-113 379.5 13.8 2.4 3 0 0 3 3 3 1 Mitochondrial protein from FMP27 Fmp27_WPPW PF10359.4 CDF87210.1 - 9e-102 340.9 3.3 1.5e-101 340.2 2.3 1.4 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Apt1 PF10351.4 CDF87210.1 - 2.3e-84 283.8 5.2 4.1e-60 203.9 0.1 3.1 2 1 1 3 3 3 2 Golgi-body localisation protein domain Fmp27_GFWDK PF10347.4 CDF87210.1 - 2e-55 186.9 0.0 5.8e-55 185.4 0.0 1.9 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.4 CDF87210.1 - 2.8e-52 176.6 3.3 1e-51 174.8 1.3 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.4 CDF87210.1 - 5.4e-28 97.4 0.0 3.7e-27 94.7 0.0 2.6 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain RRM_6 PF14259.1 CDF87211.1 - 3e-11 43.1 0.0 6.7e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CDF87211.1 - 0.00011 21.6 0.0 0.0003 20.3 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF87211.1 - 0.0047 16.7 0.0 0.0079 16.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2956 PF11169.3 CDF87211.1 - 0.25 11.3 3.8 0.48 10.4 2.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) ORC4_C PF14629.1 CDF87212.1 - 2.1e-33 115.4 0.5 4.9e-33 114.2 0.4 1.6 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.1 CDF87212.1 - 1.5e-06 28.2 0.1 3.2e-06 27.2 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain ParB PF08775.5 CDF87212.1 - 0.052 13.8 0.1 0.052 13.8 0.1 3.7 4 0 0 4 4 4 0 ParB family DUF4163 PF13739.1 CDF87212.1 - 2.6 8.9 6.6 1.2 9.9 0.7 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4163) Pkinase PF00069.20 CDF87213.1 - 3.4e-71 239.4 0.0 5.7e-71 238.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF87213.1 - 8.3e-29 100.4 0.1 6.5e-28 97.4 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Seadorna_VP7 PF07387.6 CDF87213.1 - 0.011 14.6 0.2 0.017 13.9 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kinase-like PF14531.1 CDF87213.1 - 0.12 11.3 0.0 0.22 10.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like RGS PF00615.14 CDF87214.1 - 1.6e-18 66.9 0.2 2.2e-12 47.1 0.1 2.6 2 0 0 2 2 2 2 Regulator of G protein signaling domain DEP PF00610.16 CDF87214.1 - 3.4e-11 42.7 0.0 5e-10 38.9 0.0 2.5 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) MAM33 PF02330.11 CDF87214.1 - 0.078 12.7 0.0 0.24 11.1 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial glycoprotein GTP_EFTU PF00009.22 CDF87215.1 - 2.3e-38 131.5 0.0 3.9e-38 130.7 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain eIF2_C PF09173.6 CDF87215.1 - 2.7e-35 120.2 0.2 5.8e-35 119.2 0.1 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.20 CDF87215.1 - 2.6e-11 43.4 0.5 9.7e-11 41.6 0.4 2.1 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 CDF87215.1 - 0.011 15.6 0.0 0.027 14.4 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase Dynamin_N PF00350.18 CDF87215.1 - 0.048 13.4 0.0 0.88 9.3 0.0 2.8 3 0 0 3 3 3 0 Dynamin family Zn_clus PF00172.13 CDF87216.1 - 1.4e-08 34.4 10.9 2.6e-08 33.6 7.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.11 CDF87217.1 - 7.1e-29 100.6 26.0 1e-17 63.8 11.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CDF87217.1 - 1.4e-14 53.3 20.4 1.5e-09 36.7 1.6 2.6 2 1 1 3 3 3 2 MFS/sugar transport protein ATG22 PF11700.3 CDF87217.1 - 5.7e-05 21.7 6.5 5.7e-05 21.7 4.5 3.2 2 1 0 3 3 3 1 Vacuole effluxer Atg22 like Sugar_tr PF00083.19 CDF87217.1 - 0.00015 20.5 24.7 0.0012 17.5 17.1 2.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.2 CDF87217.1 - 0.15 11.8 0.2 0.15 11.8 0.1 4.0 5 0 0 5 5 5 0 MFS_1 like family OATP PF03137.15 CDF87217.1 - 0.2 9.6 11.8 0.037 12.0 1.5 3.0 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Carn_acyltransf PF00755.15 CDF87218.1 - 1.4e-73 247.9 0.0 2.9e-58 197.4 0.0 2.1 2 0 0 2 2 2 2 Choline/Carnitine o-acyltransferase Ribosomal_S7 PF00177.16 CDF87219.1 - 6.4e-40 136.1 0.9 8.7e-40 135.7 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e ATP-synt_ab PF00006.20 CDF87220.1 - 4.8e-62 209.2 0.0 7.2e-62 208.6 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 CDF87220.1 - 8.9e-26 90.5 0.2 1.7e-25 89.6 0.2 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 CDF87220.1 - 6.6e-25 87.1 2.5 1.2e-24 86.2 0.7 2.2 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain KaiC PF06745.8 CDF87220.1 - 0.0083 15.2 0.2 0.015 14.3 0.1 1.5 1 0 0 1 1 1 1 KaiC NB-ARC PF00931.17 CDF87220.1 - 0.024 13.4 0.9 0.48 9.2 0.1 2.3 2 0 0 2 2 2 0 NB-ARC domain NACHT PF05729.7 CDF87220.1 - 0.025 14.2 0.1 0.062 12.9 0.0 1.7 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.1 CDF87220.1 - 0.036 13.4 0.1 0.091 12.1 0.0 1.8 1 1 0 1 1 1 0 AAA domain MobB PF03205.9 CDF87220.1 - 0.046 13.4 0.4 2.1 8.0 0.1 3.0 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B Arch_ATPase PF01637.13 CDF87220.1 - 0.053 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase AAA_16 PF13191.1 CDF87220.1 - 0.064 13.2 0.2 0.19 11.7 0.1 2.1 1 1 0 1 1 1 0 AAA ATPase domain DUF258 PF03193.11 CDF87220.1 - 0.076 12.1 0.2 0.13 11.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_22 PF13401.1 CDF87220.1 - 0.081 13.0 0.0 0.25 11.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA PF00004.24 CDF87220.1 - 0.083 13.0 0.0 0.61 10.2 0.0 2.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 CDF87220.1 - 0.11 12.6 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase P5CR_dimer PF14748.1 CDF87221.1 - 6e-32 109.8 0.8 1e-31 109.1 0.6 1.4 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.12 CDF87221.1 - 2.7e-07 30.9 0.2 2e-06 28.1 0.2 2.4 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.11 CDF87221.1 - 2.4e-05 23.8 0.7 9.5e-05 21.8 0.5 2.2 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.10 CDF87221.1 - 0.0046 16.8 0.0 0.22 11.3 0.0 2.3 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase DapB_N PF01113.15 CDF87221.1 - 0.052 13.4 0.0 0.12 12.2 0.0 1.7 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_Gly3P_dh_N PF01210.18 CDF87221.1 - 0.077 12.7 0.5 0.2 11.4 0.3 1.8 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus JmjC PF02373.17 CDF87222.1 - 1.8e-40 137.7 0.4 4.2e-40 136.5 0.2 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.24 CDF87222.1 - 1.2e-13 50.4 3.2 1.2e-13 50.4 2.2 2.3 2 0 0 2 2 2 1 PHD-finger JmjN PF02375.12 CDF87222.1 - 6.1e-10 38.4 0.0 1.5e-09 37.2 0.0 1.7 1 0 0 1 1 1 1 jmjN domain PHD_2 PF13831.1 CDF87222.1 - 0.027 13.7 0.2 0.027 13.7 0.1 2.3 2 0 0 2 2 2 0 PHD-finger Ilm1 PF10311.4 CDF87223.1 - 2.9e-41 140.7 8.8 4e-41 140.2 6.1 1.2 1 0 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 Bap31 PF05529.7 CDF87223.1 - 0.67 9.3 3.8 0.4 10.1 1.1 1.6 1 1 0 1 1 1 0 B-cell receptor-associated protein 31-like DUF2301 PF10063.4 CDF87223.1 - 1.7 8.8 6.0 0.37 10.9 1.5 1.7 2 0 0 2 2 2 0 Uncharacterized integral membrane protein (DUF2301) Med17 PF10156.4 CDF87224.1 - 1.2e-139 465.6 8.7 1.5e-139 465.2 6.0 1.1 1 0 0 1 1 1 1 Subunit 17 of Mediator complex Rpn3_C PF08375.6 CDF87225.1 - 1.1e-20 73.7 1.4 2.3e-20 72.7 1.0 1.6 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal PCI PF01399.22 CDF87225.1 - 3.5e-20 72.2 0.4 1.1e-19 70.7 0.3 1.9 1 0 0 1 1 1 1 PCI domain Peptidase_M48 PF01435.13 CDF87226.1 - 8.9e-49 166.0 0.0 1.3e-48 165.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M48 DUF2268 PF10026.4 CDF87226.1 - 0.0022 17.3 0.0 0.0041 16.5 0.0 1.3 1 0 0 1 1 1 1 Predicted Zn-dependent protease (DUF2268) Peptidase_M56 PF05569.6 CDF87226.1 - 0.042 12.8 0.6 0.12 11.3 0.3 1.8 1 1 0 1 1 1 0 BlaR1 peptidase M56 DUF2201_N PF13203.1 CDF87226.1 - 0.052 12.7 0.1 0.15 11.1 0.1 1.7 2 0 0 2 2 2 0 Putative metallopeptidase domain TRAM_LAG1_CLN8 PF03798.11 CDF87227.1 - 3.4e-28 98.5 17.6 3.4e-28 98.5 12.2 1.8 2 0 0 2 2 2 1 TLC domain PfkB PF00294.19 CDF87228.1 - 5.8e-68 229.2 0.2 8.8e-68 228.6 0.1 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.7 CDF87228.1 - 0.00019 20.7 0.0 0.00035 19.8 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Na_Ca_ex PF01699.19 CDF87229.1 - 5.1e-45 152.5 27.5 7.8e-30 103.3 5.8 2.9 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Lipase_3 PF01764.20 CDF87230.1 - 5.1e-37 126.6 0.0 7.9e-37 126.0 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Thioesterase PF00975.15 CDF87230.1 - 0.081 13.1 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Esterase PF00756.15 CDF87230.1 - 0.12 11.8 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Putative esterase G-alpha PF00503.15 CDF87231.1 - 2.3e-115 385.4 5.8 2.8e-115 385.1 4.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 CDF87231.1 - 1.9e-15 56.5 0.8 3.9e-10 39.2 0.3 2.7 2 1 0 2 2 2 2 ADP-ribosylation factor family Miro PF08477.8 CDF87231.1 - 0.0016 18.9 1.5 0.49 10.9 0.0 3.3 3 1 1 4 4 4 1 Miro-like protein Gtr1_RagA PF04670.7 CDF87231.1 - 0.017 14.2 10.1 0.022 13.8 0.2 3.0 3 1 1 4 4 4 0 Gtr1/RagA G protein conserved region AAA_29 PF13555.1 CDF87231.1 - 0.029 13.8 0.3 0.069 12.6 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain BAF1_ABF1 PF04684.8 CDF87231.1 - 0.24 10.2 8.4 0.38 9.5 5.8 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor GTP_EFTU PF00009.22 CDF87231.1 - 0.34 10.3 3.5 1.5 8.2 0.0 2.8 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Pox_Ag35 PF03286.9 CDF87231.1 - 1.8 8.0 9.0 0.43 10.0 4.1 1.5 2 0 0 2 2 2 0 Pox virus Ag35 surface protein DUF4557 PF15101.1 CDF87231.1 - 7.3 6.3 11.1 13 5.5 7.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) Pam17 PF08566.5 CDF87232.1 - 1.7e-72 242.7 0.0 2e-72 242.4 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 Pmp3 PF01679.12 CDF87233.1 - 1.3e-17 63.1 6.0 1.6e-17 62.9 4.2 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator WBP-1 PF11669.3 CDF87233.1 - 0.07 13.2 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 WW domain-binding protein 1 F-box PF00646.28 CDF87234.1 - 0.00026 20.5 0.2 0.0012 18.4 0.1 2.2 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.2 CDF87234.1 - 0.0003 20.4 1.7 0.0007 19.2 0.2 2.4 2 0 0 2 2 2 1 F-box-like Zn_clus PF00172.13 CDF87235.1 - 1.7e-08 34.1 11.1 3.9e-08 33.0 7.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Las1 PF04031.8 CDF87236.1 - 1e-52 177.8 0.6 3.4e-52 176.2 0.2 2.0 2 0 0 2 2 2 1 Las1-like IFRD PF05004.8 CDF87236.1 - 0.014 14.5 0.2 0.024 13.7 0.2 1.3 1 0 0 1 1 1 0 Interferon-related developmental regulator (IFRD) RNA_polI_A34 PF08208.6 CDF87237.1 - 4e-26 91.9 17.6 7.3e-26 91.0 11.6 1.8 1 1 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 Med19 PF10278.4 CDF87237.1 - 0.29 10.7 14.5 0.04 13.6 6.4 1.9 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 TFIIE_beta PF02186.10 CDF87238.1 - 2.3e-21 75.5 2.3 5e-21 74.4 1.6 1.6 1 0 0 1 1 1 1 TFIIE beta subunit core domain DUF1987 PF09345.5 CDF87238.1 - 0.0041 16.8 0.6 0.0084 15.8 0.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1987) DUF1090 PF06476.7 CDF87239.1 - 0.027 14.1 0.2 0.049 13.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) CRAL_TRIO PF00650.15 CDF87241.1 - 1.1e-26 93.2 1.3 1.7e-26 92.6 0.3 1.6 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 CDF87241.1 - 0.12 12.5 1.4 0.19 11.8 0.1 2.0 2 0 0 2 2 2 0 CRAL/TRIO, N-terminal domain BATS PF06968.8 CDF87242.1 - 4.5e-27 93.7 0.0 1.2e-26 92.3 0.0 1.7 1 0 0 1 1 1 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.16 CDF87242.1 - 1.4e-16 61.0 0.2 1e-15 58.2 0.1 2.0 2 0 0 2 2 2 1 Radical SAM superfamily DUF716 PF04819.7 CDF87243.1 - 0.00014 21.3 2.8 0.00036 19.9 2.0 1.7 1 0 0 1 1 1 1 Family of unknown function (DUF716) Actin PF00022.14 CDF87244.1 - 1.6e-53 181.5 0.0 2e-53 181.2 0.0 1.1 1 0 0 1 1 1 1 Actin Gaa1 PF04114.9 CDF87247.1 - 3e-117 392.4 18.1 9.1e-115 384.2 4.7 2.1 1 1 1 2 2 2 2 Gaa1-like, GPI transamidase component rve PF00665.21 CDF87248.1 - 0.079 13.0 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain Aminotran_1_2 PF00155.16 CDF87249.1 - 8.9e-38 130.1 0.0 1.3e-37 129.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 CDF87249.1 - 0.011 14.8 0.0 0.033 13.3 0.0 1.8 2 0 0 2 2 2 0 Beta-eliminating lyase NUDIX PF00293.23 CDF87250.1 - 1.1e-20 73.5 0.2 1.3e-20 73.3 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain DUF3225 PF11533.3 CDF87250.1 - 0.056 13.1 0.0 0.094 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3225) DUF410 PF04190.8 CDF87251.1 - 1.2e-78 264.3 2.1 1.4e-78 264.0 1.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF410) Sigma70_r2 PF04542.9 CDF87251.1 - 0.024 14.2 0.1 0.17 11.5 0.0 2.3 2 0 0 2 2 2 0 Sigma-70 region 2 RHD3 PF05879.7 CDF87252.1 - 6.1e-241 801.4 23.6 7.6e-241 801.1 16.4 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.18 CDF87252.1 - 3.7e-05 23.6 0.2 0.00022 21.0 0.0 2.4 2 0 0 2 2 2 1 Dynamin family Miro PF08477.8 CDF87252.1 - 0.00011 22.6 1.1 0.0008 19.8 0.0 2.7 2 0 0 2 2 2 1 Miro-like protein MMR_HSR1 PF01926.18 CDF87252.1 - 0.00022 21.1 0.1 0.00092 19.1 0.0 2.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase SUKH_5 PF14567.1 CDF87252.1 - 0.02 14.3 0.8 0.068 12.6 0.1 2.3 2 0 0 2 2 2 0 SMI1-KNR4 cell-wall AAA_18 PF13238.1 CDF87252.1 - 0.028 14.7 2.0 20 5.4 0.2 3.7 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.1 CDF87252.1 - 0.24 11.5 3.2 1.2 9.2 0.0 3.2 3 1 1 4 4 4 0 AAA domain MRP_L53 PF10780.4 CDF87254.1 - 7.7e-21 73.8 0.0 1.1e-20 73.3 0.0 1.2 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 DUF947 PF06102.7 CDF87255.1 - 4.4e-44 150.2 28.5 4.4e-44 150.2 19.8 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF947) EHN PF06441.7 CDF87255.1 - 0.52 10.2 5.8 2.3 8.1 4.0 2.2 1 1 0 1 1 1 0 Epoxide hydrolase N terminus Rhodanese PF00581.15 CDF87256.1 - 2e-13 50.6 0.0 2.4e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain Rhodanese PF00581.15 CDF87257.1 - 9.2e-16 58.1 0.0 1.2e-15 57.8 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain His_Phos_1 PF00300.17 CDF87258.1 - 1.1e-29 103.6 0.1 1.3e-29 103.3 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) zf-H2C2 PF09337.5 CDF87258.1 - 0.13 11.6 0.3 0.36 10.2 0.2 1.7 1 0 0 1 1 1 0 His(2)-Cys(2) zinc finger Mre11_DNA_bind PF04152.9 CDF87259.1 - 3.2e-54 183.4 0.2 6.6e-54 182.4 0.1 1.6 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.23 CDF87259.1 - 3.1e-26 91.9 1.0 5.1e-26 91.3 0.7 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Phosducin PF02114.11 CDF87260.1 - 1.1e-11 43.9 3.1 1.9e-06 26.8 0.0 2.1 2 0 0 2 2 2 2 Phosducin APG6 PF04111.7 CDF87260.1 - 0.0014 17.7 0.5 0.0021 17.1 0.4 1.2 1 0 0 1 1 1 1 Autophagy protein Apg6 UCH PF00443.24 CDF87261.1 - 1.9e-55 187.8 6.0 3.4e-55 187.0 4.2 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CDF87261.1 - 5.6e-28 98.2 5.1 1.1e-27 97.2 3.5 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 CDF87261.1 - 5.4e-13 48.8 6.8 5.4e-13 48.8 4.7 3.7 4 1 0 4 4 4 1 Zn-finger in ubiquitin-hydrolases and other protein FSH1 PF03959.8 CDF87262.1 - 5.5e-62 208.9 0.0 6.2e-62 208.7 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 CDF87262.1 - 9.7e-08 31.8 0.0 1.3e-07 31.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CDF87262.1 - 0.00011 22.1 0.0 0.48 10.2 0.0 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 CDF87262.1 - 0.0019 17.7 1.2 0.0032 16.9 0.2 1.8 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase FSH1 PF03959.8 CDF87263.1 - 1.5e-67 227.1 0.1 1.7e-67 226.9 0.1 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 CDF87263.1 - 6.9e-08 32.3 0.0 9.2e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 CDF87263.1 - 0.001 18.5 0.1 0.0022 17.4 0.1 1.6 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.15 CDF87263.1 - 0.039 13.5 0.0 2.4 7.6 0.0 2.2 2 0 0 2 2 2 0 alpha/beta hydrolase fold MFS_1 PF07690.11 CDF87264.1 - 2.5e-08 33.0 22.6 2.5e-08 33.0 15.7 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily GHMP_kinases_N PF00288.21 CDF87265.1 - 1.7e-14 53.6 0.1 3.4e-14 52.6 0.1 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 CDF87265.1 - 6.1e-07 29.5 0.0 1.6e-06 28.2 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal TRAPPC10 PF12584.3 CDF87267.1 - 2.6e-15 56.1 0.0 4.8e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 Foie-gras_1 PF11817.3 CDF87267.1 - 0.0012 18.3 0.1 0.0024 17.4 0.0 1.4 1 0 0 1 1 1 1 Foie gras liver health family 1 SicP-binding PF09119.5 CDF87267.1 - 0.11 12.1 0.0 0.29 10.8 0.0 1.6 1 0 0 1 1 1 0 SicP binding HEM4 PF02602.10 CDF87268.1 - 1.2e-40 139.1 0.0 1.4e-40 138.9 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD GMP_synt_C PF00958.17 CDF87269.1 - 2e-41 139.5 0.0 4.2e-41 138.5 0.0 1.6 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.23 CDF87269.1 - 2.6e-39 134.6 0.0 4e-39 134.0 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 CDF87269.1 - 7.1e-09 35.4 0.0 2.2e-08 33.8 0.0 1.9 1 1 1 2 2 2 1 Peptidase C26 NAD_synthase PF02540.12 CDF87269.1 - 8.1e-09 34.7 0.0 4.3e-05 22.5 0.0 2.2 2 0 0 2 2 2 2 NAD synthase tRNA_Me_trans PF03054.11 CDF87269.1 - 0.006 15.1 0.0 0.013 14.0 0.0 1.5 1 0 0 1 1 1 1 tRNA methyl transferase QueC PF06508.8 CDF87269.1 - 0.018 14.3 0.0 0.56 9.4 0.0 2.2 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC Arginosuc_synth PF00764.14 CDF87269.1 - 0.093 11.7 0.1 0.15 11.0 0.1 1.2 1 0 0 1 1 1 0 Arginosuccinate synthase Asn_synthase PF00733.16 CDF87269.1 - 0.11 11.9 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 Asparagine synthase ATP_bind_3 PF01171.15 CDF87269.1 - 0.16 11.4 0.0 0.28 10.6 0.0 1.4 1 0 0 1 1 1 0 PP-loop family Pkinase PF00069.20 CDF87270.1 - 4.9e-43 147.1 0.4 4.5e-22 78.4 0.4 2.6 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDF87270.1 - 8.8e-12 44.6 0.8 4.6e-08 32.4 0.3 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase DnaJ PF00226.26 CDF87272.1 - 1.7e-27 94.9 0.7 2.7e-27 94.2 0.5 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 CDF87272.1 - 3.3e-14 52.6 17.3 5.2e-14 52.0 12.0 1.3 1 0 0 1 1 1 1 DnaJ central domain CTDII PF01556.13 CDF87272.1 - 9.4e-11 41.4 0.0 3e-08 33.4 0.0 3.2 3 0 0 3 3 3 1 DnaJ C terminal domain HypA PF01155.14 CDF87272.1 - 0.039 13.6 7.0 0.94 9.1 0.5 2.2 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family FdhE PF04216.7 CDF87272.1 - 0.26 10.9 4.4 0.62 9.7 3.0 1.6 1 1 0 1 1 1 0 Protein involved in formate dehydrogenase formation DZR PF12773.2 CDF87272.1 - 8.6 6.2 10.9 67 3.4 7.5 2.1 1 1 0 1 1 1 0 Double zinc ribbon Septin PF00735.13 CDF87274.1 - 1.1e-112 375.6 0.0 1.7e-112 375.0 0.0 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 CDF87274.1 - 1.7e-06 27.9 0.0 3.2e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 CDF87274.1 - 7.6e-05 21.9 1.2 0.00014 21.1 0.1 1.9 2 1 0 2 2 2 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 CDF87274.1 - 0.0038 16.6 0.2 0.029 13.8 0.0 2.3 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 CDF87274.1 - 0.0073 16.4 0.0 0.018 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CDF87274.1 - 0.011 15.6 0.1 0.029 14.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain AIG1 PF04548.11 CDF87274.1 - 0.012 14.7 1.1 0.014 14.5 0.0 1.6 2 0 0 2 2 2 0 AIG1 family Miro PF08477.8 CDF87274.1 - 0.014 15.8 0.0 0.068 13.6 0.0 2.1 2 0 0 2 2 2 0 Miro-like protein RNA_helicase PF00910.17 CDF87274.1 - 0.026 14.7 0.0 0.055 13.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.1 CDF87274.1 - 0.027 14.0 0.0 0.047 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.18 CDF87274.1 - 0.032 14.0 3.5 5.6 6.7 0.0 3.2 2 1 1 3 3 3 0 Dynamin family ABC_tran PF00005.22 CDF87274.1 - 0.062 13.5 0.1 0.24 11.6 0.0 2.0 2 0 0 2 2 2 0 ABC transporter Sigma54_activat PF00158.21 CDF87274.1 - 0.067 12.6 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Pox_A32 PF04665.7 CDF87274.1 - 0.069 12.4 0.0 0.15 11.3 0.0 1.5 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_16 PF13191.1 CDF87274.1 - 0.077 12.9 0.5 0.24 11.3 0.1 2.2 2 1 0 2 2 2 0 AAA ATPase domain FtsK_SpoIIIE PF01580.13 CDF87274.1 - 0.11 11.9 0.1 0.25 10.7 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family PduV-EutP PF10662.4 CDF87274.1 - 0.15 11.5 0.4 0.63 9.5 0.1 2.1 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Pyr_redox_2 PF07992.9 CDF87275.1 - 1.3e-25 90.4 0.0 1.8e-25 89.9 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CDF87275.1 - 1.2e-19 70.4 0.3 8.8e-16 58.0 0.0 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CDF87275.1 - 4.4e-09 36.6 0.0 3.4e-05 23.9 0.0 2.6 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.1 CDF87275.1 - 0.00031 20.9 0.0 0.23 11.7 0.0 2.3 2 0 0 2 2 2 2 Putative NAD(P)-binding Thi4 PF01946.12 CDF87275.1 - 0.00052 19.1 0.0 0.003 16.6 0.0 2.0 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.19 CDF87275.1 - 0.0011 17.9 1.4 0.42 9.3 0.2 2.4 1 1 1 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.1 CDF87275.1 - 0.0013 18.6 0.0 0.019 14.9 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.17 CDF87275.1 - 0.0014 17.5 3.1 0.51 9.1 0.2 3.4 3 1 0 4 4 4 2 Glucose inhibited division protein A Shikimate_DH PF01488.15 CDF87275.1 - 0.0085 16.1 0.1 2.8 8.0 0.0 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase DAO PF01266.19 CDF87275.1 - 0.053 12.4 0.3 2.7 6.7 0.0 2.6 1 1 1 3 3 3 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 CDF87275.1 - 0.067 12.2 0.1 3.2 6.7 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain NAD_Gly3P_dh_N PF01210.18 CDF87275.1 - 0.069 12.8 0.2 7.4 6.2 0.1 2.4 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus HI0933_like PF03486.9 CDF87275.1 - 0.088 11.2 0.2 1.4 7.3 0.1 2.3 1 1 0 2 2 2 0 HI0933-like protein PX PF00787.19 CDF87276.1 - 9.8e-14 51.1 0.1 1.2e-13 50.8 0.1 1.2 1 0 0 1 1 1 1 PX domain Colipase-like PF15083.1 CDF87276.1 - 0.047 13.6 0.6 0.24 11.3 0.1 2.0 1 1 1 2 2 2 0 Colipase-like Aldo_ket_red PF00248.16 CDF87277.1 - 2.3e-54 184.1 0.0 2.8e-54 183.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PQ-loop PF04193.9 CDF87278.1 - 4.1e-36 122.3 6.2 1.2e-18 66.3 0.7 2.5 2 0 0 2 2 2 2 PQ loop repeat Zip PF02535.17 CDF87279.1 - 0.46 9.4 4.3 0.83 8.5 3.0 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter SelP_N PF04592.9 CDF87279.1 - 3 7.1 12.8 8.2 5.7 8.9 1.7 1 0 0 1 1 1 0 Selenoprotein P, N terminal region NAD_binding_10 PF13460.1 CDF87280.1 - 2.3e-11 44.0 0.3 2.7e-11 43.8 0.2 1.0 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 CDF87280.1 - 1.9e-09 36.6 0.1 2.2e-09 36.4 0.1 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 CDF87280.1 - 5.3e-09 35.8 0.1 5.9e-09 35.7 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.20 CDF87280.1 - 1.4e-06 28.3 0.4 1.9e-06 27.9 0.3 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.8 CDF87280.1 - 3.7e-06 26.3 0.3 3.8e-06 26.3 0.2 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.7 CDF87280.1 - 0.00011 21.1 0.1 0.0085 15.0 0.1 2.0 1 1 1 2 2 2 2 Male sterility protein DapB_N PF01113.15 CDF87280.1 - 0.00095 19.0 0.4 0.001 18.9 0.2 1.2 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus RmlD_sub_bind PF04321.12 CDF87280.1 - 0.0024 16.8 0.0 0.0031 16.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain TrkA_N PF02254.13 CDF87280.1 - 0.0031 17.4 0.1 0.0033 17.4 0.1 1.2 1 0 0 1 1 1 1 TrkA-N domain KR PF08659.5 CDF87280.1 - 0.0055 16.3 0.5 0.0074 15.9 0.3 1.3 1 0 0 1 1 1 1 KR domain ApbA PF02558.11 CDF87280.1 - 0.0093 15.4 0.1 0.01 15.2 0.1 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.9 CDF87280.1 - 0.022 14.1 0.2 0.026 13.8 0.2 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Ldh_1_N PF00056.18 CDF87280.1 - 0.17 11.7 0.6 0.21 11.4 0.4 1.3 1 1 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Pkinase PF00069.20 CDF87281.1 - 1.2e-70 237.6 0.1 2.2e-70 236.7 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF87281.1 - 2.2e-51 174.4 0.0 3.4e-51 173.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF87281.1 - 3e-07 29.7 0.3 3.3e-05 22.9 0.0 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.18 CDF87281.1 - 0.15 11.8 0.1 4.7 6.8 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family ImpA-rel_N PF06812.7 CDF87282.1 - 0.035 13.8 0.0 0.081 12.6 0.0 1.6 1 0 0 1 1 1 0 ImpA-related N-terminal ATP-synt_S1 PF05827.7 CDF87283.1 - 7.6e-43 146.8 0.0 9.7e-43 146.4 0.0 1.0 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) PGP_phosphatase PF09419.5 CDF87284.1 - 2.4e-70 235.2 0.0 2.7e-70 235.1 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.1 CDF87284.1 - 0.00069 19.2 0.0 0.0011 18.5 0.0 1.4 1 1 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 CDF87284.1 - 0.0074 16.7 0.1 0.012 16.0 0.1 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase FAT PF02259.18 CDF87285.1 - 6e-69 232.6 8.4 6e-69 232.6 5.8 2.3 3 0 0 3 3 3 1 FAT domain PI3_PI4_kinase PF00454.22 CDF87285.1 - 2.4e-44 151.5 1.4 5.3e-44 150.4 0.3 2.2 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.15 CDF87285.1 - 1.6e-05 24.2 0.0 4.7e-05 22.7 0.0 1.9 1 0 0 1 1 1 1 FATC domain TPR_11 PF13414.1 CDF87285.1 - 0.059 13.0 3.5 0.082 12.5 0.1 3.0 3 0 0 3 3 3 0 TPR repeat Asp PF00026.18 CDF87286.1 - 2.1e-28 99.5 2.1 2.1e-28 99.5 1.5 2.4 2 1 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 CDF87286.1 - 0.00032 20.6 0.2 0.00094 19.1 0.2 1.8 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal SR-25 PF10500.4 CDF87286.1 - 0.033 13.6 7.5 0.085 12.3 5.2 1.6 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Sec23_trunk PF04811.10 CDF87287.1 - 9.7e-57 192.1 0.1 2.3e-56 190.8 0.0 1.6 2 0 0 2 2 2 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 CDF87287.1 - 6.4e-22 76.9 0.1 1.5e-21 75.7 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 CDF87287.1 - 4e-14 52.9 0.0 8.9e-14 51.7 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 CDF87287.1 - 2.9e-11 42.7 1.6 6.5e-11 41.6 1.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 CDF87287.1 - 5.7e-08 32.3 0.0 1.7e-07 30.8 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat Pal1 PF08316.6 CDF87288.1 - 2.8e-52 176.8 1.3 2.8e-52 176.8 0.9 2.4 2 0 0 2 2 2 1 Pal1 cell morphology protein Sod_Fe_C PF02777.13 CDF87289.1 - 1e-09 38.1 0.3 0.0006 19.6 0.1 2.5 1 1 1 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Rhodanese PF00581.15 CDF87290.1 - 4.3e-12 46.3 0.0 5.4e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Svf1 PF08622.5 CDF87291.1 - 5.1e-134 446.3 3.9 6e-134 446.1 2.7 1.1 1 0 0 1 1 1 1 Svf1-like CDC45 PF02724.9 CDF87291.1 - 0.0091 14.0 0.9 0.01 13.9 0.7 1.3 1 0 0 1 1 1 1 CDC45-like protein NPR3 PF03666.8 CDF87291.1 - 0.037 12.5 3.4 0.058 11.9 2.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Spore_coat_CotO PF14153.1 CDF87291.1 - 0.45 9.9 12.0 0.95 8.8 8.3 1.5 1 0 0 1 1 1 0 Spore coat protein CotO IncA PF04156.9 CDF87291.1 - 0.82 9.2 9.8 1.4 8.4 6.8 1.3 1 0 0 1 1 1 0 IncA protein Vfa1 PF08432.5 CDF87291.1 - 1.1 9.2 9.8 1.4 8.8 6.0 1.7 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Sugar_tr PF00083.19 CDF87292.1 - 4.1e-166 553.0 36.3 4.7e-166 552.8 25.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CDF87292.1 - 6e-32 110.7 34.6 5.4e-28 97.7 16.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Cytochrom_B_N PF00033.14 CDF87292.1 - 0.024 13.9 6.7 0.17 11.2 1.5 3.1 3 0 0 3 3 3 0 Cytochrome b(N-terminal)/b6/petB MFS_3 PF05977.8 CDF87292.1 - 0.12 10.5 4.6 0.087 10.9 2.1 1.5 2 0 0 2 2 2 0 Transmembrane secretion effector Sugar_tr PF00083.19 CDF87293.1 - 6.4e-172 572.1 35.0 7.4e-172 571.9 24.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CDF87293.1 - 9e-30 103.5 48.4 9.4e-26 90.3 18.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily tRNA-synt_1d PF00750.14 CDF87294.1 - 6.4e-100 334.4 2.9 8.1e-100 334.0 2.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.10 CDF87294.1 - 2.4e-28 98.4 0.2 5e-28 97.4 0.2 1.6 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.11 CDF87294.1 - 1.6e-10 41.4 0.0 5e-09 36.5 0.0 2.8 3 0 0 3 3 3 1 Arginyl tRNA synthetase N terminal domain Fcf1 PF04900.7 CDF87295.1 - 6e-38 128.9 0.7 8.3e-38 128.5 0.1 1.5 2 0 0 2 2 2 1 Fcf1 ING PF12998.2 CDF87296.1 - 4.2e-23 81.6 6.3 6.5e-23 81.0 4.4 1.3 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.24 CDF87296.1 - 2.8e-10 39.7 9.1 2.8e-10 39.7 6.3 1.9 2 0 0 2 2 2 1 PHD-finger zf-HC5HC2H PF13771.1 CDF87296.1 - 0.005 16.9 1.1 0.01 15.9 0.1 1.9 2 0 0 2 2 2 1 PHD-like zinc-binding domain DUF501 PF04417.7 CDF87296.1 - 0.023 14.5 1.0 0.077 12.8 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF501) 4HB_MCP_1 PF12729.2 CDF87296.1 - 0.075 12.3 3.2 0.12 11.7 2.2 1.2 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction Colicin_Pyocin PF01320.13 CDF87296.1 - 0.093 12.5 0.9 0.23 11.3 0.6 1.6 1 0 0 1 1 1 0 Colicin immunity protein / pyocin immunity protein ATG16 PF08614.6 CDF87296.1 - 0.24 11.2 5.5 0.58 9.9 3.8 1.6 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) MatE PF01554.13 CDF87297.1 - 3.5e-58 195.8 36.2 1.9e-34 118.6 5.5 2.9 3 0 0 3 3 3 2 MatE Abhydrolase_1 PF00561.15 CDF87298.1 - 1.1e-15 57.8 0.7 2.2e-14 53.5 0.5 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CDF87298.1 - 2.2e-09 37.5 0.1 1.4e-08 34.8 0.1 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 CDF87298.1 - 0.0064 15.9 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_5 PF12695.2 CDF87298.1 - 0.013 15.2 0.0 0.2 11.4 0.0 2.2 1 1 0 1 1 1 0 Alpha/beta hydrolase family Ribosomal_S15 PF00312.17 CDF87299.1 - 1.3e-26 92.1 2.0 1.5e-26 91.9 0.3 1.9 2 0 0 2 2 2 1 Ribosomal protein S15 Gar1 PF04410.9 CDF87300.1 - 1.1e-42 145.0 2.6 4.1e-42 143.2 1.8 1.8 1 1 0 1 1 1 1 Gar1/Naf1 RNA binding region MMR_HSR1 PF01926.18 CDF87301.1 - 5.3e-17 61.8 0.1 8.9e-16 57.8 0.0 2.5 3 0 0 3 3 3 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 CDF87301.1 - 2.7e-07 30.2 0.0 6.4e-07 28.9 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 CDF87301.1 - 4.2e-07 29.3 0.0 7.5e-07 28.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 CDF87301.1 - 5.7e-07 28.9 0.0 1.1e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 CDF87301.1 - 8.8e-06 25.6 0.4 0.091 12.5 0.1 2.9 1 1 2 3 3 3 2 Dynamin family AIG1 PF04548.11 CDF87301.1 - 2.3e-05 23.5 0.1 4.5e-05 22.6 0.1 1.5 1 1 0 1 1 1 1 AIG1 family SRPRB PF09439.5 CDF87301.1 - 0.00036 19.8 0.1 0.0011 18.1 0.0 1.8 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Septin PF00735.13 CDF87301.1 - 0.00061 18.8 0.1 0.00094 18.2 0.0 1.4 1 0 0 1 1 1 1 Septin AAA_29 PF13555.1 CDF87301.1 - 0.0027 17.1 0.0 0.006 16.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.22 CDF87301.1 - 0.0068 16.6 0.1 0.011 15.9 0.1 1.5 1 1 0 1 1 1 1 ABC transporter RNA_helicase PF00910.17 CDF87301.1 - 0.032 14.3 0.6 0.22 11.6 0.0 2.5 2 0 0 2 2 2 0 RNA helicase Miro PF08477.8 CDF87301.1 - 0.042 14.3 0.1 0.092 13.2 0.1 1.7 1 1 0 1 1 1 0 Miro-like protein MobB PF03205.9 CDF87301.1 - 0.046 13.4 0.0 0.12 12.0 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Ras PF00071.17 CDF87301.1 - 0.049 13.0 0.1 0.093 12.1 0.1 1.5 1 0 0 1 1 1 0 Ras family PduV-EutP PF10662.4 CDF87301.1 - 0.061 12.8 0.5 1.5 8.3 0.4 2.9 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Xpo1 PF08389.7 CDF87302.1 - 0.2 11.5 10.8 0.18 11.6 4.6 3.2 2 1 0 2 2 2 0 Exportin 1-like protein Orbi_VP6 PF01516.11 CDF87302.1 - 0.52 9.3 0.7 0.8 8.7 0.5 1.2 1 0 0 1 1 1 0 Orbivirus helicase VP6 Brix PF04427.13 CDF87303.1 - 1.2e-42 145.8 3.4 1.8e-42 145.2 2.4 1.2 1 0 0 1 1 1 1 Brix domain Pex19 PF04614.7 CDF87303.1 - 0.018 14.6 2.1 0.027 14.1 1.4 1.2 1 0 0 1 1 1 0 Pex19 protein family SBDS PF01172.13 CDF87304.1 - 7.3e-17 60.9 0.4 8e-17 60.8 0.3 1.0 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SNF2_N PF00176.18 CDF87305.1 - 2.2e-78 263.1 0.2 4.6e-78 262.0 0.1 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain HSA PF07529.8 CDF87305.1 - 2.6e-17 62.3 4.3 2.6e-17 62.3 3.0 2.5 2 0 0 2 2 2 1 HSA Helicase_C PF00271.26 CDF87305.1 - 8.6e-14 51.1 0.0 2.3e-13 49.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 CDF87305.1 - 2.2e-06 27.2 0.0 5.3e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase RRM_1 PF00076.17 CDF87306.1 - 4.8e-43 144.6 0.0 1.3e-17 63.1 0.0 4.0 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF87306.1 - 1.2e-28 98.9 0.0 4.6e-10 39.3 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF87306.1 - 1.3e-19 69.7 0.0 7e-10 38.6 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.6 CDF87306.1 - 0.00054 19.7 1.4 0.013 15.3 1.0 2.5 1 1 0 1 1 1 1 RNA binding motif DUF3824 PF12868.2 CDF87306.1 - 0.0031 18.4 3.0 0.0067 17.3 2.0 1.6 1 0 0 1 1 1 1 Domain of unknwon function (DUF3824) Nup35_RRM_2 PF14605.1 CDF87306.1 - 0.0033 17.1 0.0 0.011 15.5 0.0 1.9 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.3 CDF87306.1 - 0.0043 16.7 0.0 0.037 13.7 0.0 2.2 2 0 0 2 2 2 1 Limkain b1 TMEM51 PF15345.1 CDF87306.1 - 0.045 13.4 1.7 0.099 12.3 1.2 1.5 1 0 0 1 1 1 0 Transmembrane protein 51 TSA PF03249.8 CDF87306.1 - 0.1 11.1 2.8 0.14 10.7 2.0 1.3 1 0 0 1 1 1 0 Type specific antigen RF-1 PF00472.15 CDF87307.1 - 6.5e-39 132.2 3.7 1.3e-38 131.3 2.6 1.5 1 0 0 1 1 1 1 RF-1 domain PCRF PF03462.13 CDF87307.1 - 1.8e-28 98.5 2.4 1.9e-28 98.5 0.0 2.2 3 0 0 3 3 3 1 PCRF domain Pkinase PF00069.20 CDF87308.1 - 8.7e-72 241.3 0.0 9.8e-72 241.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF87308.1 - 1.1e-31 109.8 0.0 1.4e-31 109.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CDF87308.1 - 0.00019 21.2 0.0 0.00035 20.3 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 CDF87308.1 - 0.0032 16.4 0.1 0.0051 15.8 0.0 1.5 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.17 CDF87308.1 - 0.0059 15.9 0.2 0.0094 15.3 0.1 1.2 1 0 0 1 1 1 1 RIO1 family DAO PF01266.19 CDF87309.1 - 1e-51 175.9 0.0 1.2e-51 175.7 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CDF87309.1 - 4e-06 26.7 0.0 8.3e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CDF87309.1 - 0.00012 22.1 0.0 0.00039 20.5 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CDF87309.1 - 0.0048 15.8 0.0 0.21 10.4 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) TrkA_N PF02254.13 CDF87309.1 - 0.0062 16.5 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain Pyr_redox PF00070.22 CDF87309.1 - 0.015 15.7 0.3 0.13 12.6 0.0 2.4 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CDF87309.1 - 0.022 13.6 0.0 0.061 12.1 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain GDI PF00996.13 CDF87309.1 - 0.1 10.9 0.1 0.16 10.2 0.0 1.3 1 0 0 1 1 1 0 GDP dissociation inhibitor ApbA PF02558.11 CDF87309.1 - 0.12 11.8 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Lycopene_cycl PF05834.7 CDF87309.1 - 0.15 10.9 0.2 0.42 9.4 0.0 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein TPR_11 PF13414.1 CDF87310.1 - 1.5e-09 37.3 0.5 0.00011 21.8 0.0 3.8 2 2 1 3 3 3 2 TPR repeat TPR_2 PF07719.12 CDF87310.1 - 1.5e-07 30.7 1.2 0.016 15.1 0.0 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.1 CDF87310.1 - 7.3e-06 25.3 4.4 0.016 14.9 0.0 5.1 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.23 CDF87310.1 - 0.00016 21.0 0.0 0.12 11.9 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 CDF87310.1 - 0.0002 21.2 0.9 0.013 15.4 0.0 3.9 4 1 1 5 5 5 1 Tetratricopeptide repeat Glyco_transf_22 PF03901.12 CDF87311.1 - 2.3e-99 333.2 35.1 2.7e-99 333.0 24.3 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family HECT PF00632.20 CDF87312.1 - 9.8e-85 284.4 1.0 3e-84 282.8 0.4 1.9 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) DUF479 PF04336.7 CDF87312.1 - 0.034 14.2 0.0 0.76 9.9 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function, DUF479 SPRY PF00622.23 CDF87313.1 - 6e-13 48.9 0.0 1.2e-12 47.9 0.0 1.6 1 0 0 1 1 1 1 SPRY domain Homeobox PF00046.24 CDF87314.1 - 5.1e-18 64.4 1.8 5.1e-18 64.4 1.2 1.6 2 0 0 2 2 2 1 Homeobox domain Homeobox_KN PF05920.6 CDF87314.1 - 0.002 17.7 0.9 0.0082 15.8 0.1 2.3 2 0 0 2 2 2 1 Homeobox KN domain Aldedh PF00171.17 CDF87315.1 - 2.5e-169 563.5 0.0 2.8e-169 563.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 CDF87315.1 - 0.00056 18.7 0.0 0.001 17.8 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) Aldedh PF00171.17 CDF87316.1 - 3e-169 563.2 0.0 3.4e-169 563.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Zn_clus PF00172.13 CDF87317.1 - 5e-07 29.5 11.5 5e-07 29.5 8.0 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DNA_mis_repair PF01119.14 CDF87318.1 - 4.3e-31 106.8 0.4 8.8e-31 105.8 0.3 1.6 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 CDF87318.1 - 1.3e-13 50.7 0.1 3.3e-13 49.4 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 CDF87318.1 - 8e-09 35.2 0.0 1.8e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Nse4_C PF08743.5 CDF87319.1 - 4.8e-25 87.4 0.1 1.3e-24 85.9 0.1 1.8 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.1 CDF87319.1 - 5.4e-13 48.5 0.4 1.1e-12 47.6 0.3 1.5 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE Flu_M1_C PF08289.6 CDF87319.1 - 0.024 14.6 0.1 0.063 13.3 0.0 1.7 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain Leukemia_assc_2 PF15197.1 CDF87319.1 - 0.33 10.6 2.5 0.61 9.7 0.1 2.4 2 0 0 2 2 2 0 Leukemia-associated protein 2 Peptidase_M22 PF00814.20 CDF87320.1 - 3.3e-68 230.0 0.0 3.9e-68 229.8 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Mito_carr PF00153.22 CDF87321.1 - 5.4e-66 218.3 1.7 1e-22 79.6 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein LNS2 PF08235.8 CDF87322.1 - 3.6e-69 231.3 0.0 2.8e-68 228.4 0.0 2.1 1 1 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.9 CDF87322.1 - 8.3e-44 147.7 0.0 1.9e-43 146.6 0.0 1.7 1 0 0 1 1 1 1 lipin, N-terminal conserved region AF1Q PF15017.1 CDF87322.1 - 0.011 15.6 0.7 0.011 15.6 0.5 3.6 4 0 0 4 4 4 0 Drug resistance and apoptosis regulator Acid_phosphat_B PF03767.9 CDF87322.1 - 0.042 13.2 0.1 0.16 11.2 0.0 1.9 2 0 0 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) LisH PF08513.6 CDF87323.1 - 6e-07 29.0 0.2 9e-07 28.4 0.1 1.3 1 0 0 1 1 1 1 LisH Vezatin PF12632.2 CDF87324.1 - 1.9e-23 82.8 13.0 1.4e-22 79.9 9.0 2.2 1 1 0 1 1 1 1 Mysoin-binding motif of peroxisomes UDPGP PF01704.13 CDF87325.1 - 1.2e-45 155.8 0.0 1.6e-45 155.3 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.2 CDF87325.1 - 0.062 13.3 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 MobA-like NTP transferase domain Hydrolase PF00702.21 CDF87326.1 - 6.1e-16 59.4 0.0 3.9e-12 47.0 0.0 2.7 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CDF87326.1 - 7.8e-15 54.6 0.0 3.4e-14 52.5 0.0 2.1 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit E1-E2_ATPase PF00122.15 CDF87326.1 - 7.7e-14 51.2 0.0 1.9e-13 50.0 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase HAD PF12710.2 CDF87326.1 - 2e-13 50.9 1.9 1.6e-11 44.7 1.3 3.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DnaJ PF00226.26 CDF87327.1 - 2.5e-26 91.1 0.3 4.7e-26 90.2 0.2 1.5 1 0 0 1 1 1 1 DnaJ domain DUF633 PF04816.7 CDF87327.1 - 0.12 11.7 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF633) DNA_pol_B PF00136.16 CDF87328.1 - 3.9e-134 447.9 0.9 5.2e-134 447.5 0.6 1.1 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 CDF87328.1 - 7.9e-86 287.8 0.1 1.3e-85 287.1 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.1 CDF87328.1 - 7e-23 80.4 5.1 1.4e-22 79.4 3.5 1.5 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta RNase_H_2 PF13482.1 CDF87328.1 - 0.00035 20.4 1.2 0.003 17.3 0.1 2.8 2 1 0 2 2 2 1 RNase_H superfamily DNA_pol_B_2 PF03175.8 CDF87328.1 - 0.00055 18.7 0.7 0.0094 14.6 0.0 2.3 2 0 0 2 2 2 1 DNA polymerase type B, organellar and viral DNA_pol_B_exo2 PF10108.4 CDF87328.1 - 0.011 15.2 0.0 0.026 14.0 0.0 1.6 1 0 0 1 1 1 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB C1_1 PF00130.17 CDF87328.1 - 1 9.1 7.7 5.7 6.7 0.7 2.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase PF00069.20 CDF87329.1 - 3.6e-70 236.0 0.0 4.6e-70 235.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF87329.1 - 1.1e-34 119.6 0.0 1.5e-34 119.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.21 CDF87329.1 - 5.3e-17 61.7 1.4 1e-16 60.7 1.0 1.5 1 0 0 1 1 1 1 FHA domain Kdo PF06293.9 CDF87329.1 - 0.00063 18.8 0.1 0.0011 18.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 CDF87329.1 - 0.046 13.0 0.9 0.12 11.6 0.7 1.7 1 1 0 1 1 1 0 RIO1 family ATG16 PF08614.6 CDF87331.1 - 5.2e-23 81.8 16.7 2.7e-22 79.5 9.0 2.0 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) TMF_TATA_bd PF12325.3 CDF87331.1 - 1.7e-05 24.5 5.5 2.3e-05 24.0 3.8 1.3 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding Mod_r PF07200.8 CDF87331.1 - 0.00015 21.7 3.1 0.00016 21.5 2.2 1.2 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein IncA PF04156.9 CDF87331.1 - 0.00024 20.7 6.0 0.00029 20.4 4.2 1.2 1 0 0 1 1 1 1 IncA protein Macoilin PF09726.4 CDF87331.1 - 0.00038 18.8 3.4 0.00038 18.8 2.3 1.0 1 0 0 1 1 1 1 Transmembrane protein GAS PF13851.1 CDF87331.1 - 0.00075 18.7 6.5 0.0011 18.2 4.5 1.3 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Atg14 PF10186.4 CDF87331.1 - 0.00084 18.3 5.2 0.0011 18.0 3.6 1.2 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 Fez1 PF06818.10 CDF87331.1 - 0.00093 19.2 2.8 0.0012 18.9 2.0 1.1 1 0 0 1 1 1 1 Fez1 TMF_DNA_bd PF12329.3 CDF87331.1 - 0.0014 18.4 13.6 0.023 14.4 3.1 2.2 1 1 1 2 2 2 2 TATA element modulatory factor 1 DNA binding Jnk-SapK_ap_N PF09744.4 CDF87331.1 - 0.0023 17.9 5.2 0.0028 17.6 3.6 1.2 1 0 0 1 1 1 1 JNK_SAPK-associated protein-1 CENP-F_leu_zip PF10473.4 CDF87331.1 - 0.0039 17.0 7.9 0.0058 16.4 5.5 1.2 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4201 PF13870.1 CDF87331.1 - 0.004 16.6 9.7 0.0061 16.0 6.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) APG6 PF04111.7 CDF87331.1 - 0.0064 15.5 5.0 0.0063 15.5 3.5 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 AAA_32 PF13654.1 CDF87331.1 - 0.0095 14.6 2.6 0.0099 14.5 1.8 1.0 1 0 0 1 1 1 1 AAA domain Spc7 PF08317.6 CDF87331.1 - 0.013 14.2 6.6 0.014 14.1 4.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein CENP-Q PF13094.1 CDF87331.1 - 0.013 15.5 2.4 0.015 15.3 1.6 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit HAP1_N PF04849.8 CDF87331.1 - 0.014 14.3 4.9 0.018 14.0 3.4 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region ADIP PF11559.3 CDF87331.1 - 0.021 14.7 8.1 0.3 10.9 1.5 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Prefoldin_2 PF01920.15 CDF87331.1 - 0.027 14.2 11.8 0.15 11.8 0.3 2.6 2 1 1 3 3 2 0 Prefoldin subunit TBPIP PF07106.8 CDF87331.1 - 0.035 13.6 10.9 0.17 11.4 4.2 2.0 1 1 1 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF641 PF04859.7 CDF87331.1 - 0.041 13.6 5.3 0.11 12.2 3.6 1.9 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) DUF2968 PF11180.3 CDF87331.1 - 0.054 12.8 1.8 0.15 11.4 0.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) Tho2 PF11262.3 CDF87331.1 - 0.066 12.2 4.9 0.085 11.8 3.4 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 KLRAQ PF10205.4 CDF87331.1 - 0.067 13.2 6.1 0.2 11.7 4.3 1.8 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein Trans_reg_C PF00486.23 CDF87331.1 - 0.074 12.9 0.2 0.2 11.5 0.1 1.8 1 1 0 1 1 1 0 Transcriptional regulatory protein, C terminal DUF4322 PF14210.1 CDF87331.1 - 0.078 12.4 0.8 0.5 9.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4322) Ax_dynein_light PF10211.4 CDF87331.1 - 0.17 11.7 6.4 0.23 11.2 4.5 1.3 1 0 0 1 1 1 0 Axonemal dynein light chain DUF469 PF04320.9 CDF87331.1 - 0.17 12.6 1.5 0.5 11.1 1.0 1.8 1 1 0 1 1 1 0 Protein with unknown function (DUF469) DivIVA PF05103.8 CDF87331.1 - 0.18 11.8 9.6 6.5 6.8 1.7 3.0 1 1 2 3 3 3 0 DivIVA protein V_ATPase_I PF01496.14 CDF87331.1 - 0.2 9.5 4.6 0.22 9.3 3.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TPD52 PF04201.10 CDF87331.1 - 0.21 11.3 7.8 0.2 11.3 0.8 2.2 1 1 1 2 2 2 0 Tumour protein D52 family DUF4140 PF13600.1 CDF87331.1 - 0.29 11.5 3.5 0.52 10.7 1.1 2.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Seryl_tRNA_N PF02403.17 CDF87331.1 - 0.3 11.1 9.4 0.52 10.3 4.5 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain HALZ PF02183.13 CDF87331.1 - 0.35 10.6 7.8 23 4.7 1.2 3.9 2 1 1 3 3 3 0 Homeobox associated leucine zipper DUF1049 PF06305.6 CDF87331.1 - 0.36 10.3 1.3 14 5.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) Laminin_II PF06009.7 CDF87331.1 - 0.44 10.3 6.5 0.63 9.8 4.5 1.3 1 0 0 1 1 1 0 Laminin Domain II bZIP_1 PF00170.16 CDF87331.1 - 0.49 10.3 10.5 2.5 8.1 3.6 2.4 1 1 1 2 2 2 0 bZIP transcription factor DivIC PF04977.10 CDF87331.1 - 0.6 9.6 9.4 0.39 10.2 0.8 2.5 1 1 1 2 2 2 0 Septum formation initiator Syntaxin-6_N PF09177.6 CDF87331.1 - 0.74 10.2 5.8 4.7 7.6 4.0 2.0 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DUF848 PF05852.6 CDF87331.1 - 0.75 9.6 7.6 1.4 8.7 5.3 1.5 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) TPR_MLP1_2 PF07926.7 CDF87331.1 - 0.77 9.4 10.1 1.3 8.7 6.9 1.5 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF972 PF06156.8 CDF87331.1 - 0.85 10.0 7.8 1.7 9.0 5.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF972) bZIP_2 PF07716.10 CDF87331.1 - 0.99 9.2 9.2 0.41 10.4 1.9 3.0 2 1 0 3 3 3 0 Basic region leucine zipper Spc24 PF08286.6 CDF87331.1 - 0.99 9.1 9.4 2.1 8.0 3.0 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Tropomyosin_1 PF12718.2 CDF87331.1 - 1.2 9.0 10.6 6 6.7 7.4 1.9 1 1 0 1 1 1 0 Tropomyosin like Bap31 PF05529.7 CDF87331.1 - 1.2 8.5 6.3 3.1 7.2 0.2 2.2 1 1 1 2 2 2 0 B-cell receptor-associated protein 31-like FlxA PF14282.1 CDF87331.1 - 1.9 8.4 6.3 4.2 7.3 4.4 1.6 1 1 0 1 1 1 0 FlxA-like protein ArsA_ATPase PF02374.10 CDF87332.1 - 7.3e-115 383.1 0.0 8.5e-115 382.9 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase CbiA PF01656.18 CDF87332.1 - 5.4e-13 48.7 0.7 1e-12 47.8 0.5 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 CDF87332.1 - 7.3e-05 22.7 0.0 0.00086 19.2 0.0 2.4 1 1 0 1 1 1 1 AAA domain Fer4_NifH PF00142.13 CDF87332.1 - 0.00016 20.9 0.0 0.00034 19.9 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.17 CDF87332.1 - 0.0013 18.2 0.1 0.059 12.8 0.0 2.4 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain AAA_25 PF13481.1 CDF87332.1 - 0.0074 15.7 0.0 0.017 14.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 CDF87332.1 - 0.014 14.4 0.1 0.044 12.8 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin NACHT PF05729.7 CDF87332.1 - 0.018 14.6 0.3 0.043 13.4 0.0 1.7 2 0 0 2 2 2 0 NACHT domain PhoH PF02562.11 CDF87332.1 - 0.022 13.9 0.0 0.043 13.0 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein NB-ARC PF00931.17 CDF87332.1 - 0.052 12.3 0.1 0.12 11.2 0.1 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_19 PF13245.1 CDF87332.1 - 0.052 13.2 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain T2SE PF00437.15 CDF87332.1 - 0.082 11.7 0.1 0.16 10.8 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF848 PF05852.6 CDF87333.1 - 0.0004 20.2 10.1 0.0004 20.2 7.0 3.2 1 1 0 2 2 2 1 Gammaherpesvirus protein of unknown function (DUF848) Chordopox_A20R PF05941.8 CDF87333.1 - 0.046 12.4 0.4 0.068 11.9 0.2 1.2 1 0 0 1 1 1 0 Chordopoxvirus A20R protein Telomere_reg-2 PF10193.4 CDF87333.1 - 0.55 10.4 4.6 1.3 9.2 3.2 1.6 1 0 0 1 1 1 0 Telomere length regulation protein FUSC PF04632.7 CDF87333.1 - 2.5 6.4 3.8 4 5.7 2.6 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family GAS PF13851.1 CDF87333.1 - 4.7 6.3 31.8 0.085 12.0 7.1 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Mitofilin PF09731.4 CDF87333.1 - 6 5.3 44.4 7.2 5.1 30.7 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Peptidase_S64 PF08192.6 CDF87333.1 - 6.3 5.0 26.7 7.9 4.6 18.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 Ribosomal_S8 PF00410.14 CDF87334.1 - 3.6e-19 68.8 0.0 4.4e-19 68.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 zf-met PF12874.2 CDF87336.1 - 4.1e-07 29.9 0.8 8.1e-07 29.0 0.5 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 CDF87336.1 - 2.2e-05 24.4 1.7 5.9e-05 23.0 1.2 1.8 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-DBF PF07535.7 CDF87336.1 - 0.0068 16.0 0.8 0.015 14.9 0.6 1.6 1 0 0 1 1 1 1 DBF zinc finger zf-C2H2_2 PF12756.2 CDF87336.1 - 0.024 14.7 2.2 0.043 13.9 1.5 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.21 CDF87336.1 - 0.1 12.9 1.2 0.29 11.5 0.9 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CDF87336.1 - 0.12 12.7 0.8 0.32 11.4 0.6 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger AKAP95 PF04988.7 CDF87336.1 - 7.6 6.2 10.2 3.5 7.3 2.8 2.4 2 1 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) PNK3P PF08645.6 CDF87337.1 - 4.7e-41 139.8 0.0 5.5e-41 139.6 0.0 1.0 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase PCI PF01399.22 CDF87338.1 - 2.4e-16 59.9 0.5 1.1e-15 57.8 0.0 2.3 2 1 0 2 2 2 1 PCI domain TPR_16 PF13432.1 CDF87338.1 - 1.3e-05 25.6 6.5 0.0052 17.4 0.2 3.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_15 PF13429.1 CDF87338.1 - 0.00088 18.4 3.6 0.00088 18.4 2.5 1.9 2 1 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 CDF87338.1 - 0.0087 16.1 13.3 0.056 13.5 1.8 3.9 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.4 CDF87338.1 - 0.011 15.6 3.8 2.9 7.8 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.1 CDF87338.1 - 0.058 13.3 9.0 0.71 9.8 0.7 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 CDF87338.1 - 0.09 12.6 12.1 3 7.8 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat DDRGK PF09756.4 CDF87338.1 - 0.099 12.0 0.3 0.26 10.6 0.0 1.9 2 0 0 2 2 2 0 DDRGK domain PMT PF02366.13 CDF87339.1 - 1.7e-77 260.1 24.2 1.7e-77 260.1 16.8 2.1 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 CDF87339.1 - 2.7e-48 164.0 0.0 3.8e-48 163.5 0.0 1.2 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.1 CDF87339.1 - 2.9e-05 23.9 18.6 2.9e-05 23.9 12.9 3.1 3 1 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Nodulin-like PF06813.8 CDF87340.1 - 3.9e-16 59.0 1.8 9e-16 57.8 1.2 1.5 1 0 0 1 1 1 1 Nodulin-like DCP1 PF06058.8 CDF87341.1 - 8.6e-19 67.7 1.7 3.3e-10 40.0 0.0 3.0 2 1 1 3 3 3 3 Dcp1-like decapping family Ank_3 PF13606.1 CDF87341.1 - 0.043 14.0 0.0 0.23 11.7 0.0 2.1 2 0 0 2 2 2 0 Ankyrin repeat Spt20 PF12090.3 CDF87342.1 - 6.5e-56 188.5 3.5 6.5e-56 188.5 2.4 3.8 3 1 0 3 3 3 1 Spt20 family GAGA_bind PF06217.7 CDF87342.1 - 0.0021 18.1 6.9 0.0021 18.1 4.8 3.1 3 1 0 3 3 3 2 GAGA binding protein-like family PEX11 PF05648.9 CDF87343.1 - 9.3e-57 191.8 3.6 1.1e-56 191.6 2.5 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) HTH_5 PF01022.15 CDF87343.1 - 0.016 14.8 0.3 0.087 12.5 0.0 2.1 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family HTH_IclR PF09339.5 CDF87343.1 - 0.063 12.8 0.3 0.32 10.6 0.1 2.1 2 0 0 2 2 2 0 IclR helix-turn-helix domain Phage_int_SAM_1 PF02899.12 CDF87343.1 - 0.081 13.0 0.2 0.22 11.6 0.1 1.7 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Sld5 PF05916.6 CDF87344.1 - 5.1e-09 36.4 0.0 6.5e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 GINS complex protein TPR_11 PF13414.1 CDF87345.1 - 5.8e-27 93.1 26.4 1.7e-07 30.7 0.0 10.6 7 2 5 12 12 12 9 TPR repeat TPR_2 PF07719.12 CDF87345.1 - 1.1e-17 62.4 47.1 0.00063 19.4 0.0 12.3 13 0 0 13 13 11 7 Tetratricopeptide repeat TPR_1 PF00515.23 CDF87345.1 - 1.4e-17 62.4 43.0 6.3e-05 22.4 0.0 11.1 13 0 0 13 13 13 6 Tetratricopeptide repeat TPR_12 PF13424.1 CDF87345.1 - 2e-17 62.8 38.4 0.00012 21.9 1.5 10.6 9 3 3 13 13 12 7 Tetratricopeptide repeat Apc3 PF12895.2 CDF87345.1 - 4.1e-17 62.1 30.5 1.8e-05 24.7 0.1 9.2 7 3 3 10 10 10 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 CDF87345.1 - 5.5e-16 58.6 17.3 0.02 15.2 0.0 10.2 9 1 1 10 10 10 5 Tetratricopeptide repeat TPR_14 PF13428.1 CDF87345.1 - 6.3e-15 54.3 24.4 0.23 12.2 0.0 12.8 10 2 4 14 14 13 4 Tetratricopeptide repeat TPR_16 PF13432.1 CDF87345.1 - 1.2e-14 54.4 20.2 5.7e-06 26.8 0.0 8.8 9 1 0 9 9 8 2 Tetratricopeptide repeat TPR_8 PF13181.1 CDF87345.1 - 2.7e-13 48.6 33.1 0.0023 17.5 0.0 10.5 9 1 0 9 9 9 3 Tetratricopeptide repeat TPR_6 PF13174.1 CDF87345.1 - 8.5e-12 44.7 27.2 0.033 14.6 0.0 10.7 12 0 0 12 12 9 2 Tetratricopeptide repeat TPR_17 PF13431.1 CDF87345.1 - 1.6e-06 27.8 16.0 10 6.5 0.0 11.2 13 0 0 13 13 11 0 Tetratricopeptide repeat TPR_7 PF13176.1 CDF87345.1 - 5e-05 22.7 24.3 2.7 7.9 0.0 9.6 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_9 PF13371.1 CDF87345.1 - 0.00054 19.7 5.7 0.069 13.0 0.0 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 CDF87345.1 - 0.0088 15.9 6.5 2.1 8.2 0.0 5.7 6 0 0 6 6 6 1 Fis1 C-terminal tetratricopeptide repeat Copine PF07002.11 CDF87345.1 - 0.011 15.5 1.1 0.087 12.5 0.0 2.6 2 0 0 2 2 2 0 Copine TPR_10 PF13374.1 CDF87345.1 - 0.58 10.1 21.8 5 7.1 0.0 8.6 10 0 0 10 10 9 0 Tetratricopeptide repeat RRM_5 PF13893.1 CDF87346.1 - 0.00051 19.8 0.0 0.0013 18.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DMRL_synthase PF00885.14 CDF87347.1 - 8e-43 145.5 0.1 1e-42 145.2 0.1 1.0 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase Hist_deacetyl PF00850.14 CDF87348.1 - 4.8e-80 269.1 0.1 7.2e-80 268.5 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain AAA PF00004.24 CDF87349.1 - 3e-51 173.0 0.0 7e-44 149.2 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 CDF87349.1 - 8.6e-07 29.8 0.0 0.005 17.6 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.1 CDF87349.1 - 7.1e-05 22.9 0.0 0.02 15.0 0.0 3.1 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.1 CDF87349.1 - 0.00021 21.3 0.2 0.071 13.0 0.0 3.1 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.7 CDF87349.1 - 0.0004 19.5 0.0 0.0013 17.8 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Parvo_NS1 PF01057.12 CDF87349.1 - 0.0005 19.0 0.0 0.00086 18.2 0.0 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_5 PF07728.9 CDF87349.1 - 0.0012 18.5 0.0 0.043 13.5 0.0 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 CDF87349.1 - 0.0013 18.2 0.1 0.013 14.9 0.1 2.3 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 CDF87349.1 - 0.0023 18.0 0.0 0.028 14.5 0.0 2.7 3 0 0 3 3 3 1 RNA helicase IstB_IS21 PF01695.12 CDF87349.1 - 0.0033 16.8 0.0 0.0071 15.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.1 CDF87349.1 - 0.0066 16.7 0.0 0.46 10.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CDF87349.1 - 0.0084 15.8 0.1 0.049 13.3 0.0 2.1 2 0 0 2 2 2 1 Part of AAA domain KaiC PF06745.8 CDF87349.1 - 0.014 14.5 0.0 0.028 13.5 0.0 1.4 1 0 0 1 1 1 0 KaiC TIP49 PF06068.8 CDF87349.1 - 0.017 13.8 0.0 0.031 13.0 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus Mg_chelatase PF01078.16 CDF87349.1 - 0.019 14.1 0.1 0.039 13.0 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_2 PF07724.9 CDF87349.1 - 0.021 14.7 0.0 0.063 13.1 0.0 1.8 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_14 PF13173.1 CDF87349.1 - 0.031 14.1 0.0 0.27 11.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.6 CDF87349.1 - 0.034 13.7 0.0 0.73 9.4 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 CDF87349.1 - 0.038 13.8 0.1 0.61 9.9 0.0 2.6 3 0 0 3 3 3 0 AAA domain PhoH PF02562.11 CDF87349.1 - 0.046 12.9 0.0 0.087 12.0 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_24 PF13479.1 CDF87349.1 - 0.072 12.6 0.1 0.17 11.4 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 CDF87349.1 - 0.2 11.6 0.0 0.47 10.3 0.0 1.6 2 0 0 2 2 1 0 AAA domain DnaJ PF00226.26 CDF87350.1 - 4.7e-07 29.4 0.1 7.5e-07 28.7 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.8 CDF87350.1 - 0.0062 16.3 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 Pam16 zf-DHHC PF01529.15 CDF87352.1 - 3.2e-39 134.0 6.2 3.2e-39 134.0 4.3 1.8 2 0 0 2 2 2 1 DHHC palmitoyltransferase PsbN PF02468.10 CDF87352.1 - 2.8 7.6 5.9 1.5 8.4 0.6 2.5 2 0 0 2 2 2 0 Photosystem II reaction centre N protein (psbN) UBA_e1_C PF09358.5 CDF87353.1 - 0.0021 18.1 0.0 0.0032 17.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme e1 C-terminal domain Syja_N PF02383.13 CDF87354.1 - 9.7e-96 320.2 0.4 9.7e-96 320.2 0.3 2.4 3 0 0 3 3 3 1 SacI homology domain LCM PF04072.9 CDF87355.1 - 2.2e-25 89.2 0.0 4e-25 88.4 0.0 1.4 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Kelch_4 PF13418.1 CDF87355.1 - 3.9e-15 55.3 5.3 3.6e-08 33.0 0.0 5.0 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_3 PF13415.1 CDF87355.1 - 2.5e-11 43.4 2.0 8.8e-07 28.9 0.0 4.3 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_6 PF13964.1 CDF87355.1 - 2.5e-08 33.7 5.8 2e-05 24.5 0.0 4.9 4 1 1 5 5 5 1 Kelch motif Kelch_5 PF13854.1 CDF87355.1 - 4.4e-08 32.9 0.8 0.027 14.4 0.0 4.0 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.20 CDF87355.1 - 5.9e-07 28.9 2.9 0.0006 19.3 0.0 4.1 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.10 CDF87355.1 - 0.00012 21.6 4.9 0.035 13.8 0.0 4.2 5 0 0 5 5 5 1 Kelch motif CDC50 PF03381.10 CDF87356.1 - 2.4e-88 295.9 1.6 3.9e-88 295.2 1.1 1.3 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family OPT PF03169.10 CDF87356.1 - 0.17 10.2 0.8 0.32 9.3 0.6 1.3 1 0 0 1 1 1 0 OPT oligopeptide transporter protein PBP1_TM PF14812.1 CDF87356.1 - 8.5 6.7 8.4 4.6 7.6 2.8 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Aminotran_3 PF00202.16 CDF87357.1 - 1.4e-108 362.8 0.0 1.6e-108 362.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III PucR PF07905.6 CDF87357.1 - 0.025 14.1 0.0 0.2 11.2 0.0 2.3 2 0 0 2 2 2 0 Purine catabolism regulatory protein-like family Na_Ca_ex PF01699.19 CDF87359.1 - 4e-32 110.7 21.0 5e-19 68.2 7.5 3.9 6 0 0 6 6 6 2 Sodium/calcium exchanger protein DUF307 PF03733.8 CDF87359.1 - 1.8e-11 44.3 4.9 1.8e-11 44.3 3.4 3.5 2 0 0 2 2 2 1 Domain of unknown function (DUF307) IF4E PF01652.13 CDF87360.1 - 5.1e-56 188.7 0.7 6e-56 188.5 0.5 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Abhydrolase_5 PF12695.2 CDF87361.1 - 1.7e-19 69.9 0.0 2.7e-19 69.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CDF87361.1 - 2.6e-14 53.6 0.0 9.7e-13 48.5 0.0 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDF87361.1 - 2.6e-11 43.5 0.1 6.8e-06 25.8 0.0 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.16 CDF87361.1 - 5.4e-07 29.0 0.0 1.7e-06 27.4 0.0 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.3 CDF87361.1 - 0.0018 18.0 0.0 0.0035 17.1 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase FSH1 PF03959.8 CDF87361.1 - 0.0021 17.5 0.0 0.0026 17.2 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DUF2305 PF10230.4 CDF87361.1 - 0.004 16.6 0.1 2.5 7.4 0.1 2.1 2 0 0 2 2 2 2 Uncharacterised conserved protein (DUF2305) Abhydrolase_2 PF02230.11 CDF87361.1 - 0.0045 16.4 0.0 0.91 8.9 0.0 2.2 1 1 1 2 2 2 2 Phospholipase/Carboxylesterase DLH PF01738.13 CDF87361.1 - 0.02 14.2 0.0 0.17 11.1 0.0 2.0 1 1 0 1 1 1 0 Dienelactone hydrolase family DUF818 PF05677.7 CDF87361.1 - 0.03 13.0 0.1 0.043 12.5 0.1 1.3 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) BAAT_C PF08840.6 CDF87361.1 - 0.033 13.8 0.0 1.7 8.3 0.0 2.5 1 1 1 3 3 3 0 BAAT / Acyl-CoA thioester hydrolase C terminal PAE PF03283.8 CDF87361.1 - 0.097 11.2 0.0 0.14 10.7 0.0 1.2 1 0 0 1 1 1 0 Pectinacetylesterase WD40 PF00400.27 CDF87362.1 - 5.1e-15 54.7 3.8 1.1e-05 25.1 0.1 4.6 4 0 0 4 4 4 2 WD domain, G-beta repeat zf-rbx1 PF12678.2 CDF87362.1 - 0.00025 21.0 3.5 0.00064 19.7 2.4 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 CDF87362.1 - 0.0011 18.7 7.2 0.0027 17.5 5.0 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 CDF87362.1 - 0.15 11.7 8.9 0.013 15.1 2.2 2.3 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDF87362.1 - 4.3 7.4 13.6 0.16 12.0 4.5 2.3 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDF87362.1 - 7.8 6.3 12.0 2.8 7.7 5.6 2.3 2 1 0 2 2 2 0 zinc-RING finger domain Sugar_tr PF00083.19 CDF87363.1 - 1.2e-118 396.6 34.9 1.3e-118 396.4 24.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CDF87363.1 - 2.8e-21 75.6 40.7 1.1e-18 67.1 18.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily M11L PF11099.3 CDF87363.1 - 0.1 12.3 0.3 0.23 11.1 0.2 1.5 1 0 0 1 1 1 0 Apoptosis regulator M11L like MFS_1 PF07690.11 CDF87364.1 - 9.7e-20 70.5 37.2 2.2e-15 56.2 12.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily WD40 PF00400.27 CDF87365.1 - 1.3e-42 142.1 13.7 1.2e-09 37.6 0.2 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat eIF2A PF08662.6 CDF87365.1 - 6.4e-07 29.2 3.4 4.3e-05 23.3 1.3 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.6 CDF87365.1 - 0.0016 17.2 2.8 2.8 6.5 0.1 3.7 1 1 3 4 4 4 2 Nup133 N terminal like Apc4_WD40 PF12894.2 CDF87365.1 - 0.056 12.9 0.0 2.8 7.5 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain 6PF2K PF01591.13 CDF87366.1 - 7e-50 169.1 1.0 1.2e-49 168.3 0.7 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_33 PF13671.1 CDF87366.1 - 0.00011 22.0 0.0 0.00048 20.0 0.0 2.0 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.1 CDF87366.1 - 0.021 15.1 0.0 0.054 13.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain KTI12 PF08433.5 CDF87366.1 - 0.033 13.4 0.4 0.11 11.6 0.1 2.0 2 1 0 2 2 2 0 Chromatin associated protein KTI12 AAA_17 PF13207.1 CDF87366.1 - 0.036 14.8 0.0 0.16 12.7 0.0 2.2 2 1 0 2 2 2 0 AAA domain Med7 PF05983.6 CDF87367.1 - 5.4e-64 214.8 1.8 6.4e-64 214.6 1.2 1.0 1 0 0 1 1 1 1 MED7 protein DUF2587 PF10759.4 CDF87367.1 - 0.028 13.7 0.1 0.053 12.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2587) CENP-F_N PF10481.4 CDF87367.1 - 0.043 13.1 0.9 0.072 12.4 0.6 1.3 1 0 0 1 1 1 0 Cenp-F N-terminal domain MscS_porin PF12795.2 CDF87367.1 - 0.35 10.1 3.5 0.66 9.2 0.5 2.1 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain zf-rbx1 PF12678.2 CDF87368.1 - 9.3e-32 108.9 14.1 1.2e-31 108.6 9.7 1.1 1 0 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 CDF87368.1 - 4.1e-17 61.7 10.5 5.3e-17 61.4 7.3 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.1 CDF87368.1 - 3e-07 30.1 11.7 2.5e-06 27.2 8.1 2.1 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 CDF87368.1 - 0.0019 17.7 12.0 0.018 14.6 8.3 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDF87368.1 - 0.016 15.1 2.2 0.016 15.1 1.5 2.5 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.3 CDF87368.1 - 0.02 14.4 2.1 0.042 13.3 1.4 1.5 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_3 PF13920.1 CDF87368.1 - 0.068 12.8 10.1 2.3 7.9 7.1 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CDF87368.1 - 0.18 11.7 0.4 0.18 11.7 0.3 2.4 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.1 CDF87368.1 - 0.21 11.3 6.8 1.8 8.3 4.7 2.5 1 1 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.1 CDF87368.1 - 0.68 9.7 10.4 4.5 7.0 7.2 2.3 1 1 1 2 2 2 0 zinc-RING finger domain FANCL_C PF11793.3 CDF87368.1 - 0.82 9.6 8.8 4.8 7.2 6.3 2.0 1 1 1 2 2 2 0 FANCL C-terminal domain PDT PF00800.13 CDF87369.1 - 1.9e-52 177.4 0.6 2.4e-52 177.1 0.4 1.1 1 0 0 1 1 1 1 Prephenate dehydratase YmdB PF13277.1 CDF87369.1 - 0.056 12.4 0.0 0.15 11.0 0.0 1.7 1 1 0 2 2 2 0 YmdB-like protein ACT PF01842.20 CDF87369.1 - 0.059 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 ACT domain DUF718 PF05336.8 CDF87369.1 - 0.088 12.6 0.2 0.92 9.3 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF718) ATP11 PF06644.6 CDF87370.1 - 4.7e-92 308.2 3.1 5.3e-92 308.0 2.2 1.0 1 0 0 1 1 1 1 ATP11 protein Glutaredoxin2_C PF04399.8 CDF87370.1 - 0.083 12.4 0.4 0.17 11.4 0.3 1.4 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain Methyltransf_31 PF13847.1 CDF87371.1 - 8.1e-13 48.2 0.0 1.3e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDF87371.1 - 3.1e-10 40.4 0.1 5e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDF87371.1 - 1.6e-09 38.1 0.0 3e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDF87371.1 - 1.5e-08 34.9 0.1 3.3e-08 33.7 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDF87371.1 - 1.7e-08 35.0 0.0 3.3e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDF87371.1 - 1.3e-06 28.2 0.0 1.7e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CDF87371.1 - 4.9e-05 22.5 0.0 7.1e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.1 CDF87371.1 - 0.00053 19.6 0.0 0.0009 18.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CDF87371.1 - 0.00069 18.7 0.0 0.0012 17.8 0.0 1.5 1 1 0 1 1 1 1 Putative methyltransferase MTS PF05175.9 CDF87371.1 - 0.0021 17.4 0.0 0.01 15.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 CDF87371.1 - 0.0059 15.7 0.0 0.0078 15.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 CDF87371.1 - 0.05 13.6 0.0 0.094 12.7 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain AAA_12 PF13087.1 CDF87373.1 - 2.3e-56 190.3 0.0 6.9e-56 188.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.1 CDF87373.1 - 1.1e-43 149.5 0.7 1.1e-43 149.5 0.5 1.9 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.1 CDF87373.1 - 8.3e-11 41.8 0.0 2.3e-09 37.1 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CDF87373.1 - 3.2e-10 39.6 0.0 2.1e-09 36.9 0.0 2.2 2 0 0 2 2 2 1 Part of AAA domain Viral_helicase1 PF01443.13 CDF87373.1 - 8.5e-06 25.4 0.0 0.18 11.3 0.0 3.8 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase ResIII PF04851.10 CDF87373.1 - 0.0002 21.2 0.0 0.00086 19.1 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 CDF87373.1 - 0.001 18.6 0.1 0.0029 17.1 0.0 1.8 1 1 0 2 2 2 1 DEAD/DEAH box helicase UvrD-helicase PF00580.16 CDF87373.1 - 0.0012 18.1 1.6 0.0015 17.8 0.0 2.0 3 0 0 3 3 3 1 UvrD/REP helicase N-terminal domain AAA PF00004.24 CDF87373.1 - 0.0019 18.4 0.0 0.0061 16.7 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) UvrD_C_2 PF13538.1 CDF87373.1 - 0.004 17.2 0.0 0.24 11.5 0.0 2.6 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain PhoH PF02562.11 CDF87373.1 - 0.0049 16.1 0.1 0.024 13.8 0.0 2.0 2 0 0 2 2 2 1 PhoH-like protein DUF258 PF03193.11 CDF87373.1 - 0.007 15.5 0.1 0.007 15.5 0.1 2.0 2 1 0 2 2 2 1 Protein of unknown function, DUF258 Arch_ATPase PF01637.13 CDF87373.1 - 0.0095 15.6 0.3 0.043 13.5 0.0 2.2 2 0 0 2 2 2 1 Archaeal ATPase RNA_helicase PF00910.17 CDF87373.1 - 0.038 14.1 0.1 0.47 10.6 0.0 2.9 3 0 0 3 3 2 0 RNA helicase AAA_14 PF13173.1 CDF87373.1 - 0.053 13.4 0.3 0.78 9.6 0.0 2.8 2 1 1 3 3 3 0 AAA domain AAA_16 PF13191.1 CDF87373.1 - 0.055 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.1 CDF87373.1 - 0.066 13.3 0.0 0.35 11.0 0.0 2.3 3 0 0 3 3 1 0 AAA domain AAA_5 PF07728.9 CDF87373.1 - 0.09 12.5 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) 14-3-3 PF00244.15 CDF87374.1 - 7.3e-115 381.9 5.5 8.7e-115 381.7 3.8 1.0 1 0 0 1 1 1 1 14-3-3 protein FlaF PF07309.6 CDF87374.1 - 0.025 14.4 0.2 0.078 12.8 0.1 1.8 1 0 0 1 1 1 0 Flagellar protein FlaF COPI_assoc PF08507.5 CDF87375.1 - 3.6e-35 120.6 7.2 4e-35 120.4 5.0 1.0 1 0 0 1 1 1 1 COPI associated protein ABC2_membrane_3 PF12698.2 CDF87375.1 - 1.6 7.6 19.0 2.1 7.3 13.2 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Peptidase_M24 PF00557.19 CDF87376.1 - 2.4e-09 37.0 0.0 8.5e-09 35.2 0.0 2.0 1 1 0 1 1 1 1 Metallopeptidase family M24 E1_dh PF00676.15 CDF87377.1 - 3e-119 397.2 0.0 3.5e-119 396.9 0.0 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.1 CDF87377.1 - 0.0011 17.9 0.0 0.0019 17.2 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.16 CDF87377.1 - 0.0047 16.5 0.5 0.0083 15.7 0.3 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Ste5_C PF12194.3 CDF87378.1 - 1.4e-70 236.8 0.1 2.5e-70 236.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase Fus3-binding zf-RING_2 PF13639.1 CDF87378.1 - 3.2e-05 23.6 2.9 9.4e-05 22.1 2.0 1.9 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 CDF87378.1 - 0.021 14.5 2.2 0.06 13.0 1.5 1.9 1 1 0 1 1 1 0 zinc-RING finger domain PH_10 PF15411.1 CDF87378.1 - 0.09 12.9 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain PH_4 PF15404.1 CDF87379.1 - 2.4e-72 242.3 0.0 7.9e-72 240.6 0.0 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain Spo7_2_N PF15407.1 CDF87379.1 - 6.1e-24 83.2 0.2 1.9e-23 81.7 0.1 1.9 1 0 0 1 1 1 1 Sporulation protein family 7 Rad51 PF08423.6 CDF87380.1 - 1.3e-124 414.2 0.5 1.6e-124 413.9 0.1 1.3 2 0 0 2 2 2 1 Rad51 AAA_25 PF13481.1 CDF87380.1 - 1.3e-10 40.9 0.0 2e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.16 CDF87380.1 - 6e-09 35.4 0.1 8e-09 35.0 0.1 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein KaiC PF06745.8 CDF87380.1 - 3.3e-08 32.9 1.3 1.2e-07 31.1 0.1 2.3 2 1 0 2 2 2 1 KaiC HHH_5 PF14520.1 CDF87380.1 - 5.3e-06 26.5 0.3 1.3e-05 25.2 0.2 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain PAXNEB PF05625.6 CDF87380.1 - 0.0099 14.7 0.1 0.18 10.5 0.1 2.0 2 0 0 2 2 2 1 PAXNEB protein RNA_pol_A_CTD PF03118.10 CDF87380.1 - 0.011 15.1 0.3 0.024 14.0 0.2 1.5 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain Serinc PF03348.10 CDF87381.1 - 5.6e-147 489.9 12.3 6.5e-147 489.6 8.5 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) OCIA PF07051.6 CDF87381.1 - 0.14 11.6 1.8 0.64 9.4 0.1 2.5 1 1 0 2 2 2 0 Ovarian carcinoma immunoreactive antigen (OCIA) Lantibiotic_a PF14867.1 CDF87381.1 - 0.14 11.4 1.6 0.45 9.8 1.1 1.9 1 0 0 1 1 1 0 Lantibiotic alpha DUF202 PF02656.10 CDF87381.1 - 8.5 6.6 10.8 6.1 7.1 2.0 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF202) Nitr_red_alph_N PF14710.1 CDF87382.1 - 5.4 7.3 7.0 1.6e+02 2.6 3.3 3.1 2 1 0 2 2 2 0 Respiratory nitrate reductase alpha N-terminal DUF2205 PF10224.4 CDF87383.1 - 2.5e-08 33.3 0.6 3.4e-08 32.9 0.4 1.2 1 0 0 1 1 1 1 Predicted coiled-coil protein (DUF2205) LXG PF04740.7 CDF87383.1 - 0.076 12.7 0.3 0.093 12.5 0.2 1.1 1 0 0 1 1 1 0 LXG domain of WXG superfamily HisKA PF00512.20 CDF87383.1 - 0.16 11.9 0.8 0.55 10.2 0.4 1.8 1 1 1 2 2 2 0 His Kinase A (phospho-acceptor) domain EMP70 PF02990.11 CDF87384.1 - 7.9e-210 697.7 9.8 7.9e-210 697.7 6.8 1.5 2 0 0 2 2 2 1 Endomembrane protein 70 TRAPPC-Trs85 PF12739.2 CDF87385.1 - 3.3e-96 322.4 4.9 4.3e-96 322.0 3.4 1.1 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Rax2 PF12768.2 CDF87386.1 - 7.4e-49 166.4 1.5 7.4e-49 166.4 1.1 4.4 3 2 2 5 5 5 3 Cortical protein marker for cell polarity Orbi_VP5 PF00901.12 CDF87386.1 - 0.45 8.6 0.0 0.69 8.0 0.0 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 FGGY_C PF02782.11 CDF87387.1 - 3e-51 173.8 0.2 5.6e-51 172.9 0.1 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 CDF87387.1 - 1.1e-22 80.5 0.0 2.2e-21 76.2 0.0 2.5 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Hexokinase_1 PF00349.16 CDF87387.1 - 0.12 11.6 0.0 0.25 10.6 0.0 1.4 1 0 0 1 1 1 0 Hexokinase Tim17 PF02466.14 CDF87388.1 - 2.1e-32 111.8 5.8 2.5e-32 111.6 4.0 1.0 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family RNA_pol_Rpb4 PF03874.11 CDF87390.1 - 1.5e-36 124.9 8.3 4.3e-36 123.4 5.7 1.8 1 1 0 1 1 1 1 RNA polymerase Rpb4 FAM176 PF14851.1 CDF87390.1 - 2.9 7.5 5.7 1.6 8.3 2.6 1.6 1 1 1 2 2 2 0 FAM176 family RP-C_C PF11800.3 CDF87390.1 - 5.2 6.7 7.2 17 5.0 3.8 2.0 2 0 0 2 2 2 0 Replication protein C C-terminal region Tom37_C PF11801.3 CDF87390.1 - 9.2 6.1 8.7 1.5 8.6 2.1 1.9 1 1 1 2 2 2 0 Tom37 C-terminal domain Glyco_transf_15 PF01793.11 CDF87391.1 - 4.2e-135 449.9 10.1 5.1e-135 449.6 7.0 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Ribosomal_L1 PF00687.16 CDF87392.1 - 3.5e-43 147.5 0.6 4.3e-43 147.2 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DEAD PF00270.24 CDF87393.1 - 1.6e-43 148.1 1.2 3.2e-43 147.1 0.3 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF87393.1 - 3.9e-27 93.9 0.2 2.3e-26 91.4 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDF87393.1 - 5.9e-06 26.2 0.0 1.2e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.1 CDF87393.1 - 0.003 17.2 0.1 0.016 14.9 0.0 2.0 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 CDF87393.1 - 0.016 14.8 0.0 0.23 10.9 0.0 2.4 2 1 0 2 2 2 0 AAA domain DUF1811 PF08838.5 CDF87393.1 - 0.091 12.7 0.0 5.8 6.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1811) Glyco_transf_8 PF01501.15 CDF87394.1 - 7.6e-34 117.1 0.0 1.4e-33 116.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 8 Ribosomal_S21e PF01249.13 CDF87395.1 - 2.3e-40 136.4 0.0 2.5e-40 136.3 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e tRNA_U5-meth_tr PF05958.6 CDF87396.1 - 1.2e-21 76.8 0.0 2e-20 72.8 0.0 2.2 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.1 CDF87396.1 - 7.7e-12 45.0 0.0 2e-11 43.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDF87396.1 - 2.7e-07 31.1 0.0 7.8e-07 29.6 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain TRAM PF01938.15 CDF87396.1 - 1.4e-05 24.7 0.3 4.6e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 TRAM domain PrmA PF06325.8 CDF87396.1 - 1.8e-05 24.0 0.0 5.2e-05 22.5 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 CDF87396.1 - 5e-05 23.3 0.0 9.8e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CDF87396.1 - 0.00052 19.4 0.0 0.00094 18.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_15 PF09445.5 CDF87396.1 - 0.00066 19.2 0.1 0.0014 18.2 0.1 1.5 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Ubie_methyltran PF01209.13 CDF87396.1 - 0.00074 18.6 0.0 0.0019 17.3 0.0 1.6 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.7 CDF87396.1 - 0.002 18.5 0.0 0.0054 17.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 CDF87396.1 - 0.0048 16.5 0.1 0.035 13.6 0.0 2.3 2 0 0 2 2 2 1 Met-10+ like-protein Methyltransf_4 PF02390.12 CDF87396.1 - 0.0071 15.4 0.0 0.021 13.8 0.0 1.8 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.1 CDF87396.1 - 0.018 15.4 0.0 0.054 13.8 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain PCMT PF01135.14 CDF87396.1 - 0.11 11.9 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ras PF00071.17 CDF87397.1 - 9e-49 164.9 0.0 1.2e-48 164.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDF87397.1 - 9.5e-15 55.1 0.0 1.7e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDF87397.1 - 2.3e-06 26.9 0.0 3.7e-06 26.2 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 CDF87397.1 - 0.015 14.4 0.0 0.018 14.1 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DHC_N1 PF08385.7 CDF87398.1 - 6.1e-85 285.7 22.5 6.1e-85 285.7 15.6 3.9 4 0 0 4 4 3 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.8 CDF87398.1 - 4.8e-80 269.0 9.2 4.8e-80 269.0 6.4 5.7 7 0 0 7 7 6 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.2 CDF87398.1 - 3.7e-62 209.8 0.0 1.4e-61 207.9 0.0 2.0 2 0 0 2 2 1 1 Hydrolytic ATP binding site of dynein motor region D1 Dynein_heavy PF03028.10 CDF87398.1 - 1.4e-42 145.6 0.1 1.4e-42 145.6 0.1 2.3 2 0 0 2 2 2 1 Dynein heavy chain and region D6 of dynein motor AAA_9 PF12781.2 CDF87398.1 - 3.9e-27 94.5 0.1 1.8e-26 92.3 0.1 2.2 1 0 0 1 1 1 1 ATP-binding dynein motor region D5 AAA_5 PF07728.9 CDF87398.1 - 2e-25 89.1 1.6 1.8e-10 40.6 0.1 6.1 5 1 0 5 5 5 3 AAA domain (dynein-related subfamily) AAA_8 PF12780.2 CDF87398.1 - 2.1e-25 89.2 0.0 5.4e-25 87.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 MT PF12777.2 CDF87398.1 - 8.1e-24 84.0 9.2 8.1e-24 84.0 6.4 1.8 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.2 CDF87398.1 - 1.7e-18 66.6 0.1 4.1e-17 62.1 0.0 2.8 2 0 0 2 2 2 1 P-loop containing dynein motor region D3 AAA PF00004.24 CDF87398.1 - 3.2e-14 53.2 3.0 0.012 15.8 0.0 6.2 5 0 0 5 5 5 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CDF87398.1 - 6.5e-13 48.9 7.1 0.015 15.4 0.0 7.6 5 1 1 6 6 6 3 AAA domain AAA_16 PF13191.1 CDF87398.1 - 1.6e-10 41.2 0.1 0.28 11.1 0.0 5.8 4 1 1 5 5 5 3 AAA ATPase domain AAA_17 PF13207.1 CDF87398.1 - 2.6e-07 31.4 0.6 0.097 13.4 0.0 5.3 4 0 0 4 4 3 2 AAA domain Zeta_toxin PF06414.7 CDF87398.1 - 1.1e-06 27.8 0.0 0.02 14.0 0.0 4.3 4 0 0 4 4 4 1 Zeta toxin AAA_18 PF13238.1 CDF87398.1 - 3.5e-06 27.3 3.0 0.56 10.5 0.0 5.2 4 0 0 4 4 3 2 AAA domain T2SE PF00437.15 CDF87398.1 - 6.7e-06 25.1 0.1 0.087 11.7 0.0 4.4 4 0 0 4 4 4 1 Type II/IV secretion system protein AAA_33 PF13671.1 CDF87398.1 - 1.5e-05 24.8 0.4 0.29 10.9 0.0 4.3 4 0 0 4 4 3 1 AAA domain IstB_IS21 PF01695.12 CDF87398.1 - 0.00016 21.1 0.5 0.35 10.2 0.0 4.0 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_19 PF13245.1 CDF87398.1 - 0.00058 19.5 1.7 2.3 8.0 0.0 4.0 4 0 0 4 4 4 1 Part of AAA domain UPF0079 PF02367.12 CDF87398.1 - 0.00086 18.9 3.0 7.6 6.1 0.0 4.6 5 0 0 5 5 4 0 Uncharacterised P-loop hydrolase UPF0079 AAA_30 PF13604.1 CDF87398.1 - 0.0013 18.3 4.0 7.2 6.1 0.1 4.5 5 0 0 5 5 4 0 AAA domain RNA_helicase PF00910.17 CDF87398.1 - 0.0022 18.1 0.3 10 6.3 0.0 4.6 4 0 0 4 4 4 0 RNA helicase AAA_28 PF13521.1 CDF87398.1 - 0.0044 17.0 1.2 31 4.4 0.0 4.5 4 0 0 4 4 4 0 AAA domain AAA_25 PF13481.1 CDF87398.1 - 0.0079 15.6 0.2 1.8 7.8 0.0 3.9 4 0 0 4 4 4 1 AAA domain Mg_chelatase PF01078.16 CDF87398.1 - 0.035 13.2 0.4 0.47 9.5 0.0 2.8 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI AAA_11 PF13086.1 CDF87398.1 - 1.1 8.7 15.9 17 4.8 3.6 5.3 5 0 0 5 5 5 0 AAA domain PAP2 PF01569.16 CDF87399.1 - 4.5e-16 58.7 1.9 4.5e-16 58.7 1.3 1.8 2 0 0 2 2 2 1 PAP2 superfamily Fer4_5 PF12801.2 CDF87399.1 - 1.5 8.6 7.8 0.26 11.1 1.8 2.5 2 1 0 2 2 2 0 4Fe-4S binding domain Mito_carr PF00153.22 CDF87400.1 - 2.1e-63 210.0 3.0 4.3e-22 77.6 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Solute_trans_a PF03619.11 CDF87401.1 - 8.1e-75 251.6 13.8 1e-74 251.3 9.6 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Zn_dep_PLPC PF00882.13 CDF87402.1 - 1.2e-18 67.2 0.7 2.2e-18 66.4 0.5 1.4 1 0 0 1 1 1 1 Zinc dependent phospholipase C mIF3 PF14877.1 CDF87403.1 - 1.9e-63 213.0 9.1 1.9e-63 213.0 6.3 1.8 3 0 0 3 3 3 1 Mitochondrial translation initiation factor CPSase_L_D2 PF02786.12 CDF87404.1 - 1.6e-113 377.2 1.0 6.2e-83 277.2 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.17 CDF87404.1 - 2.7e-47 159.5 0.0 6.5e-47 158.3 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.23 CDF87404.1 - 2.8e-44 150.8 0.0 5.6e-44 149.8 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I OTCace_N PF02729.16 CDF87404.1 - 6e-42 142.6 0.2 1.7e-41 141.2 0.0 1.9 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_chain PF00289.17 CDF87404.1 - 1.1e-40 138.1 0.1 2.7e-20 72.5 0.0 2.9 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, N-terminal domain CPSase_L_D3 PF02787.14 CDF87404.1 - 4e-40 136.4 0.1 9.6e-40 135.1 0.1 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.19 CDF87404.1 - 2.2e-33 115.3 0.1 1.6e-32 112.5 0.0 2.4 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain ATP-grasp_4 PF13535.1 CDF87404.1 - 3.2e-33 115.0 0.2 1.3e-21 77.1 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.1 CDF87404.1 - 3.4e-24 85.2 0.1 2.9e-13 49.2 0.0 3.5 3 0 0 3 3 3 3 ATP-grasp in the biosynthetic pathway with Ter operon MGS PF02142.17 CDF87404.1 - 4.5e-22 77.7 0.0 2.2e-21 75.5 0.0 2.4 1 0 0 1 1 1 1 MGS-like domain Dala_Dala_lig_C PF07478.8 CDF87404.1 - 4.7e-15 55.5 1.4 1e-07 31.5 0.2 2.7 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 CDF87404.1 - 2.9e-13 49.5 0.1 4.2e-06 26.2 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain Peptidase_C26 PF07722.8 CDF87404.1 - 1e-05 25.1 0.0 0.00081 18.8 0.0 2.6 1 1 0 1 1 1 1 Peptidase C26 ATP-grasp_3 PF02655.9 CDF87404.1 - 3.1e-05 23.9 0.6 0.19 11.6 0.1 2.7 2 0 0 2 2 2 2 ATP-grasp domain TrkH PF02386.11 CDF87405.1 - 8.7e-131 435.6 13.9 3.2e-130 433.8 4.3 2.3 2 0 0 2 2 2 2 Cation transport protein Pkinase PF00069.20 CDF87406.1 - 2.6e-55 187.3 0.0 5.6e-55 186.2 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF87406.1 - 4e-37 127.7 0.0 5.5e-37 127.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF87406.1 - 3.6e-05 22.8 0.0 5.8e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 CDF87406.1 - 0.01 14.6 0.0 0.017 14.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 TAT_signal PF10518.4 CDF87407.1 - 0.027 14.4 0.1 0.032 14.2 0.1 1.2 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence DUF4271 PF14093.1 CDF87407.1 - 0.16 11.6 1.4 0.17 11.5 0.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4271) zf-H2C2 PF09337.5 CDF87408.1 - 3.6e-20 71.0 6.9 6e-20 70.3 4.8 1.4 1 0 0 1 1 1 1 His(2)-Cys(2) zinc finger Acetyltransf_1 PF00583.19 CDF87408.1 - 0.00026 20.9 0.0 0.00072 19.5 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Imm47 PF15586.1 CDF87408.1 - 0.024 14.4 0.2 0.052 13.3 0.2 1.6 1 0 0 1 1 1 0 Immunity protein 47 CN_hydrolase PF00795.17 CDF87409.1 - 5.9e-27 94.2 0.0 1e-26 93.4 0.0 1.4 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase GCD14 PF08704.5 CDF87410.1 - 6.9e-77 258.2 0.1 1.1e-75 254.2 0.0 2.1 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.1 CDF87410.1 - 2.2e-05 24.0 0.0 3.3e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CDF87410.1 - 5.6e-05 23.1 0.0 0.00011 22.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDF87410.1 - 0.00024 21.6 0.1 0.0011 19.4 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase domain RrnaAD PF00398.15 CDF87410.1 - 0.00064 18.8 0.0 0.0013 17.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase PCMT PF01135.14 CDF87410.1 - 0.0012 18.3 0.0 0.003 17.1 0.0 1.8 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.12 CDF87410.1 - 0.013 14.5 0.0 0.068 12.2 0.0 2.0 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_23 PF13489.1 CDF87410.1 - 0.014 15.1 0.0 0.043 13.5 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 CDF87410.1 - 0.072 12.4 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain DUF3748 PF12566.3 CDF87410.1 - 0.092 12.6 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3748) LSM PF01423.17 CDF87411.1 - 2.3e-13 49.4 0.0 3.6e-13 48.8 0.0 1.3 1 0 0 1 1 1 1 LSM domain DUF1687 PF07955.6 CDF87412.1 - 1e-33 116.1 0.5 1.1e-33 115.9 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) DUF2413 PF10310.4 CDF87413.1 - 9.4e-109 364.1 24.8 1.5e-108 363.5 17.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2413) Alb1 PF09135.6 CDF87414.1 - 7.9e-18 65.0 7.7 1.1e-17 64.5 5.4 1.2 1 0 0 1 1 1 1 Alb1 DUF4404 PF14357.1 CDF87414.1 - 1.5 9.2 4.2 2.1 8.8 1.1 2.4 1 1 1 3 3 3 0 Domain of unknown function (DUF4404) Ribul_P_3_epim PF00834.14 CDF87415.1 - 1.8e-70 236.1 0.0 2.7e-70 235.5 0.0 1.3 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family OMPdecase PF00215.19 CDF87415.1 - 0.013 14.9 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family NAP PF00956.13 CDF87416.1 - 1.8e-78 263.0 8.4 1.8e-78 263.0 5.8 2.5 2 1 0 2 2 2 1 Nucleosome assembly protein (NAP) Mst1_SARAH PF11629.3 CDF87416.1 - 0.049 13.4 3.0 0.25 11.1 0.1 2.7 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 PRP38_assoc PF12871.2 CDF87418.1 - 0.004 17.6 14.8 0.004 17.6 10.3 2.4 2 1 0 2 2 2 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF1777 PF08648.7 CDF87418.1 - 0.014 15.1 16.0 0.014 15.1 11.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1777) Pho86 PF11124.3 CDF87419.1 - 1.9e-73 247.1 0.2 2.2e-73 246.9 0.1 1.0 1 0 0 1 1 1 1 Inorganic phosphate transporter Pho86 Lectin_leg-like PF03388.8 CDF87420.1 - 4.5e-09 35.7 0.0 2.4e-06 26.8 0.0 2.2 2 0 0 2 2 2 2 Legume-like lectin family His_Phos_1 PF00300.17 CDF87421.1 - 5.1e-29 101.3 0.0 6.2e-29 101.1 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) SUN PF03856.8 CDF87422.1 - 2.5e-95 318.5 18.9 3.7e-95 317.9 13.1 1.2 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) GCOM2 PF15328.1 CDF87422.1 - 0.12 12.1 2.2 0.17 11.5 1.5 1.2 1 0 0 1 1 1 0 Putative GRINL1B complex locus protein 2 Fmp27 PF10344.4 CDF87422.1 - 0.94 7.0 9.9 1.2 6.7 6.8 1.1 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 ASF1_hist_chap PF04729.8 CDF87423.1 - 1.4e-66 222.9 0.1 2.1e-66 222.3 0.1 1.3 1 0 0 1 1 1 1 ASF1 like histone chaperone Nop14 PF04147.7 CDF87423.1 - 0.014 13.3 38.0 0.016 13.1 26.3 1.1 1 0 0 1 1 1 0 Nop14-like family CENP-T PF15511.1 CDF87423.1 - 0.26 10.4 27.1 0.34 10.0 18.8 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T CDC45 PF02724.9 CDF87423.1 - 0.31 9.0 24.1 0.4 8.6 16.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Daxx PF03344.10 CDF87423.1 - 0.65 8.4 38.0 0.85 8.0 26.4 1.2 1 0 0 1 1 1 0 Daxx Family SDA1 PF05285.7 CDF87423.1 - 3.7 6.7 38.9 5.4 6.2 26.9 1.3 1 0 0 1 1 1 0 SDA1 Vfa1 PF08432.5 CDF87423.1 - 3.7 7.5 20.0 5.8 6.8 13.8 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 VID27 PF08553.5 CDF87423.1 - 3.8 5.6 22.3 5.4 5.1 15.5 1.4 1 0 0 1 1 1 0 VID27 cytoplasmic protein eIF-3c_N PF05470.7 CDF87423.1 - 6 4.8 16.7 7 4.6 11.6 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DUF1510 PF07423.6 CDF87423.1 - 7.2 5.9 30.8 11 5.3 21.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) YABBY PF04690.8 CDF87424.1 - 0.03 14.5 0.5 0.057 13.6 0.3 1.6 1 0 0 1 1 1 0 YABBY protein RE_AlwI PF09491.5 CDF87424.1 - 0.075 11.4 0.0 0.11 10.8 0.0 1.2 1 0 0 1 1 1 0 AlwI restriction endonuclease AA_permease PF00324.16 CDF87425.1 - 1.5e-145 485.2 37.6 1.7e-145 485.0 26.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CDF87425.1 - 1.7e-37 129.0 38.8 2.3e-37 128.5 26.9 1.0 1 0 0 1 1 1 1 Amino acid permease Peptidase_M22 PF00814.20 CDF87426.1 - 6e-82 275.1 0.0 7.4e-82 274.8 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family DASH_Spc34 PF08657.5 CDF87427.1 - 4.8e-60 203.3 0.3 5.6e-60 203.1 0.2 1.0 1 0 0 1 1 1 1 DASH complex subunit Spc34 DHquinase_I PF01487.10 CDF87427.1 - 0.099 12.2 0.2 0.16 11.6 0.1 1.3 1 0 0 1 1 1 0 Type I 3-dehydroquinase Occludin_ELL PF07303.8 CDF87427.1 - 7.1 7.4 8.6 7.4 7.3 4.0 2.3 2 1 0 2 2 2 0 Occludin homology domain WD40 PF00400.27 CDF87428.1 - 1.1e-31 107.4 11.5 3.2e-08 33.1 0.1 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat Nup160 PF11715.3 CDF87428.1 - 3.1e-08 32.2 10.2 0.0043 15.2 0.0 5.3 2 1 3 5 5 5 4 Nucleoporin Nup120/160 Mdv1 PF11542.3 CDF87428.1 - 2.4e-05 24.1 0.6 5.5e-05 22.9 0.4 1.5 1 0 0 1 1 1 1 Mitochondrial division protein 1 PQQ_2 PF13360.1 CDF87428.1 - 0.0096 15.4 0.8 1.2 8.5 0.1 2.4 2 0 0 2 2 2 2 PQQ-like domain DUF3249 PF11615.3 CDF87428.1 - 0.014 15.1 0.1 1.7 8.4 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3249) Cpn60_TCP1 PF00118.19 CDF87429.1 - 2.2e-144 481.7 6.3 2.5e-144 481.5 4.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Herpes_U59 PF04529.7 CDF87429.1 - 0.031 13.1 0.0 0.047 12.5 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus U59 protein Snf7 PF03357.16 CDF87430.1 - 8.5e-16 57.8 15.2 1.3e-15 57.2 10.5 1.2 1 0 0 1 1 1 1 Snf7 T2SM PF04612.7 CDF87430.1 - 0.031 14.0 6.3 0.94 9.2 0.0 2.4 1 1 0 2 2 2 0 Type II secretion system (T2SS), protein M DUF2580 PF10824.3 CDF87430.1 - 0.066 13.5 1.1 0.25 11.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2580) DUF444 PF04285.7 CDF87430.1 - 1.8 7.0 10.6 16 3.9 7.4 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF444) GrpE PF01025.14 CDF87430.1 - 3.8 7.0 13.0 0.17 11.4 4.5 1.8 1 1 1 2 2 2 0 GrpE GATA PF00320.22 CDF87431.1 - 2.9e-15 55.2 2.3 6.3e-15 54.2 1.6 1.6 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.7 CDF87431.1 - 0.1 11.9 2.7 0.38 10.0 1.6 2.0 1 1 1 2 2 2 0 TFIIB zinc-binding GCR1_C PF12550.3 CDF87432.1 - 2.2e-20 72.2 1.1 2.2e-20 72.2 0.7 2.1 2 1 0 2 2 2 1 Transcriptional activator of glycolytic enzymes AAA PF00004.24 CDF87433.1 - 7.8e-42 142.6 0.0 1.7e-41 141.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 CDF87433.1 - 2.9e-05 23.2 0.0 6.4e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 CDF87433.1 - 3e-05 24.1 0.1 0.002 18.2 0.1 2.7 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 CDF87433.1 - 4.9e-05 23.3 0.2 0.00016 21.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.8 CDF87433.1 - 0.00017 20.4 0.0 0.00038 19.2 0.0 1.5 1 0 0 1 1 1 1 TIP49 C-terminus AAA_5 PF07728.9 CDF87433.1 - 0.00026 20.7 0.1 0.0069 16.1 0.0 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Vps4_C PF09336.5 CDF87433.1 - 0.00045 20.0 0.0 0.005 16.7 0.0 2.5 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_14 PF13173.1 CDF87433.1 - 0.0016 18.2 0.0 0.0044 16.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 CDF87433.1 - 0.0032 16.8 0.2 0.51 9.7 0.1 2.5 1 1 1 2 2 2 1 AAA domain Mg_chelatase PF01078.16 CDF87433.1 - 0.0038 16.4 0.1 0.0096 15.0 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.12 CDF87433.1 - 0.004 16.5 0.0 0.009 15.4 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.1 CDF87433.1 - 0.0048 16.9 0.3 0.02 14.9 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.1 CDF87433.1 - 0.0066 16.7 0.3 0.044 14.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CDF87433.1 - 0.0076 15.9 0.1 0.031 14.0 0.0 2.0 2 0 0 2 2 2 1 Part of AAA domain AAA_17 PF13207.1 CDF87433.1 - 0.015 16.1 1.7 0.047 14.4 0.0 2.5 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.1 CDF87433.1 - 0.02 14.7 0.0 0.088 12.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 CDF87433.1 - 0.044 13.4 0.1 1.7 8.3 0.0 2.4 1 1 1 2 2 2 0 NACHT domain AAA_23 PF13476.1 CDF87433.1 - 1.3 9.3 8.6 14 5.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain Glyco_transf_15 PF01793.11 CDF87434.1 - 2.5e-116 388.2 6.5 3.1e-116 387.9 4.5 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase UCH PF00443.24 CDF87435.1 - 3e-36 124.9 4.3 7.8e-33 113.7 0.4 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Pox_F15 PF04596.7 CDF87435.1 - 0.031 13.8 0.0 0.074 12.6 0.0 1.6 1 0 0 1 1 1 0 Poxvirus protein F15 SH3_1 PF00018.23 CDF87436.1 - 2e-20 71.8 0.0 2e-09 36.6 0.0 2.8 3 0 0 3 3 3 2 SH3 domain PX PF00787.19 CDF87436.1 - 2.2e-13 49.9 0.0 5.3e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 PX domain SH3_9 PF14604.1 CDF87436.1 - 1.5e-09 37.2 1.4 1.1e-05 24.9 0.0 3.1 3 0 0 3 3 3 2 Variant SH3 domain PB1 PF00564.19 CDF87436.1 - 1.2e-08 34.5 0.0 2.3e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 PB1 domain SH3_2 PF07653.12 CDF87436.1 - 7.6e-06 25.3 0.0 5.8e-05 22.5 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain HPIP PF15226.1 CDF87436.1 - 0.031 14.3 0.0 0.067 13.2 0.0 1.5 1 0 0 1 1 1 0 HCF-1 beta-propeller-interacting protein family VPS9 PF02204.13 CDF87438.1 - 1.6e-18 66.6 1.4 3.4e-18 65.5 1.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain polyprenyl_synt PF00348.12 CDF87439.1 - 9.1e-44 149.2 0.0 1.1e-43 148.9 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase DER1 PF04511.10 CDF87440.1 - 4.2e-38 130.8 6.4 4.8e-38 130.6 4.4 1.0 1 0 0 1 1 1 1 Der1-like family DUF1538 PF07556.6 CDF87440.1 - 0.068 12.2 1.4 5.4 6.0 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1538) DUF454 PF04304.8 CDF87440.1 - 2.4 8.2 5.0 9.1 6.3 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF454) KxDL PF10241.4 CDF87441.1 - 0.25 11.2 1.4 3.5 7.5 0.0 2.7 3 0 0 3 3 3 0 Uncharacterized conserved protein DUF2746 PF10874.3 CDF87441.1 - 1.3 9.2 4.2 35 4.6 0.6 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2746) DUF3605 PF12239.3 CDF87442.1 - 2.9e-33 114.9 0.0 3.6e-33 114.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) OPT PF03169.10 CDF87443.1 - 8.4e-157 523.2 45.1 9.7e-157 523.0 31.3 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Band_7 PF01145.20 CDF87444.1 - 2.7e-25 89.3 1.7 4.7e-25 88.5 1.0 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.1 CDF87444.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family UQ_con PF00179.21 CDF87445.1 - 2e-38 130.9 0.0 2.2e-38 130.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.8 CDF87445.1 - 0.00092 18.8 0.2 0.0012 18.5 0.2 1.2 1 0 0 1 1 1 1 UEV domain RWD PF05773.17 CDF87445.1 - 0.002 18.0 0.0 0.0021 17.9 0.0 1.3 1 0 0 1 1 1 1 RWD domain UFC1 PF08694.6 CDF87445.1 - 0.0071 15.8 0.0 0.0089 15.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 Prok-E2_B PF14461.1 CDF87445.1 - 0.026 14.3 0.1 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B Ribonuc_L-PSP PF01042.16 CDF87446.1 - 3.5e-20 71.9 0.0 4.1e-20 71.7 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Pet20 PF08692.5 CDF87447.1 - 1.6e-48 164.1 0.1 2e-48 163.7 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial protein Pet20 WW PF00397.21 CDF87449.1 - 1.3e-13 50.4 0.9 5.4e-08 32.5 0.9 2.5 2 0 0 2 2 2 2 WW domain FF PF01846.14 CDF87449.1 - 3.8e-05 23.5 1.4 3.8e-05 23.5 1.0 3.6 5 0 0 5 5 5 1 FF domain Proteasome PF00227.21 CDF87450.1 - 1.9e-57 193.6 0.8 2.3e-57 193.3 0.5 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 CDF87450.1 - 2e-13 49.3 2.6 4.2e-13 48.3 0.2 2.3 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Lipocalin_6 PF13944.1 CDF87450.1 - 0.034 14.2 0.6 2.7 8.1 0.2 2.2 2 0 0 2 2 2 0 Lipocalin-like domain Tmemb_170 PF10190.4 CDF87451.1 - 0.001 19.0 4.3 0.0013 18.7 3.0 1.1 1 0 0 1 1 1 1 Putative transmembrane protein 170 SH3_9 PF14604.1 CDF87453.1 - 2.1e-14 52.7 0.0 3.6e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 CDF87453.1 - 4.6e-14 51.5 0.0 7.5e-14 50.8 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 CDF87453.1 - 3.8e-10 39.0 0.0 5.6e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain DUF2076 PF09849.4 CDF87453.1 - 0.064 13.3 4.7 0.1 12.6 3.3 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) PAT1 PF09770.4 CDF87453.1 - 3.3 5.8 9.9 3.6 5.7 6.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 NCA2 PF08637.5 CDF87454.1 - 1.1e-90 303.4 2.7 1.6e-90 302.9 1.9 1.2 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 Gp_dh_C PF02800.15 CDF87455.1 - 1.3e-73 245.6 0.1 2.3e-73 244.8 0.1 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.19 CDF87455.1 - 9.6e-59 197.6 0.3 1.6e-58 196.9 0.2 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.15 CDF87455.1 - 0.0022 17.9 1.4 0.0056 16.5 0.4 2.3 2 1 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus 2-Hacid_dh_C PF02826.14 CDF87455.1 - 0.098 11.8 0.1 0.44 9.6 0.0 1.9 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ATP-sulfurylase PF01747.12 CDF87456.1 - 5.8e-88 293.7 0.0 8.8e-88 293.1 0.0 1.3 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.1 CDF87456.1 - 2.3e-52 176.6 0.0 3.6e-52 175.9 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain Biotin_lipoyl PF00364.17 CDF87457.1 - 5e-18 64.5 0.7 2.1e-17 62.5 0.5 2.1 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.12 CDF87457.1 - 1.2e-05 24.7 0.6 3.4e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 e3 binding domain Biotin_lipoyl_2 PF13533.1 CDF87457.1 - 0.0056 16.3 2.1 0.015 14.9 0.1 2.7 3 0 0 3 3 3 1 Biotin-lipoyl like SAF PF08666.7 CDF87457.1 - 0.0057 17.0 1.9 0.66 10.4 0.0 3.1 3 0 0 3 3 3 2 SAF domain FGGY_N PF00370.16 CDF87458.1 - 1.4e-22 80.2 0.0 3.2e-13 49.5 0.0 2.2 2 0 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.11 CDF87458.1 - 2.5e-12 46.8 0.0 7.9e-12 45.2 0.0 1.9 2 1 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain SPC12 PF06645.8 CDF87459.1 - 1.1e-20 73.2 0.2 1.2e-20 73.0 0.1 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) Polysacc_synt_3 PF13440.1 CDF87459.1 - 0.027 13.9 0.1 0.028 13.8 0.0 1.0 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein MFS_1 PF07690.11 CDF87460.1 - 7.6e-29 100.5 43.0 5.7e-28 97.6 28.4 2.5 1 1 2 3 3 3 2 Major Facilitator Superfamily MFS_2 PF13347.1 CDF87460.1 - 4.6e-10 38.4 15.2 8.5e-08 30.9 6.5 2.3 2 1 0 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.2 CDF87460.1 - 0.014 15.1 0.1 0.014 15.1 0.0 3.5 4 0 0 4 4 4 0 MFS_1 like family Mito_carr PF00153.22 CDF87462.1 - 2.9e-53 177.5 5.7 1e-18 66.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Mannosyl_trans PF05007.8 CDF87464.1 - 8.3e-88 294.3 23.2 2e-87 293.1 16.1 1.6 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.8 CDF87464.1 - 1e-06 27.9 25.0 3e-06 26.3 17.3 1.9 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U DUF2029 PF09594.5 CDF87464.1 - 8.2e-06 25.4 8.0 8.2e-06 25.4 5.5 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF2029) RNase_PH PF01138.16 CDF87465.1 - 1.4e-26 93.3 0.1 2e-26 92.8 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 CDF87465.1 - 0.00026 20.8 0.1 0.0006 19.7 0.1 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 SUI1 PF01253.17 CDF87467.1 - 3.3e-21 74.8 2.1 5.8e-21 74.0 1.4 1.4 1 0 0 1 1 1 1 Translation initiation factor SUI1 Apc4 PF12896.2 CDF87467.1 - 0.045 13.0 0.1 0.091 12.0 0.0 1.3 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 4 MethyltransfD12 PF02086.10 CDF87467.1 - 0.13 11.7 0.7 0.2 11.1 0.0 1.6 2 0 0 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase Img2 PF05046.9 CDF87467.1 - 0.58 10.4 3.6 20 5.4 2.5 2.3 1 1 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) DUF947 PF06102.7 CDF87467.1 - 1.6 8.4 11.5 0.061 13.1 3.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF947) TPR_16 PF13432.1 CDF87468.1 - 2.6e-05 24.7 1.0 0.026 15.1 0.0 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 CDF87468.1 - 0.00033 21.0 0.2 0.057 14.0 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 CDF87468.1 - 0.0098 15.5 7.1 0.47 10.1 0.8 3.4 3 0 0 3 3 3 2 TPR repeat TPR_19 PF14559.1 CDF87468.1 - 0.17 12.2 3.5 1.1 9.6 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 CDF87468.1 - 2.2 8.4 11.3 23 5.2 0.1 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat Thi4 PF01946.12 CDF87469.1 - 5.1e-93 310.4 0.0 6e-93 310.1 0.0 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.19 CDF87469.1 - 2e-06 26.9 0.2 4e-06 25.9 0.1 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 CDF87469.1 - 2e-05 24.4 0.1 0.00014 21.6 0.0 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 CDF87469.1 - 4.3e-05 23.4 0.0 9.9e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 CDF87469.1 - 0.00013 21.0 0.1 0.0002 20.4 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.19 CDF87469.1 - 0.00075 18.4 0.4 0.0047 15.8 0.1 2.0 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.9 CDF87469.1 - 0.0094 14.4 0.2 0.017 13.6 0.1 1.4 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.9 CDF87469.1 - 0.014 15.2 0.6 0.017 14.9 0.3 1.6 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CDF87469.1 - 0.025 14.6 0.0 0.047 13.7 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase PMT PF02366.13 CDF87471.1 - 1.3e-84 283.4 20.7 1.3e-84 283.4 14.3 2.1 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 CDF87471.1 - 4.6e-22 78.4 1.3 7.4e-22 77.8 0.9 1.3 1 0 0 1 1 1 1 MIR domain WD40 PF00400.27 CDF87472.1 - 8.8e-62 202.9 26.3 2.5e-10 39.8 0.0 11.5 13 0 0 13 13 13 9 WD domain, G-beta repeat CTP_transf_2 PF01467.21 CDF87473.1 - 3.5e-22 79.1 0.0 7.8e-22 78.0 0.0 1.6 1 0 0 1 1 1 1 Cytidylyltransferase FAD_syn PF06574.7 CDF87473.1 - 0.072 12.7 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 FAD synthetase Rhodanese PF00581.15 CDF87474.1 - 4.7e-12 46.2 0.0 5.8e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Rotamase PF00639.16 CDF87475.1 - 8.9e-25 87.2 0.1 1.5e-24 86.5 0.1 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.1 CDF87475.1 - 1.4e-18 67.2 0.0 1.9e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 CDF87475.1 - 1.3e-09 38.7 0.0 2.2e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.21 CDF87475.1 - 1.8e-07 30.9 1.6 2.7e-07 30.2 1.1 1.3 1 0 0 1 1 1 1 WW domain FTHFS PF01268.14 CDF87476.1 - 1.3e-254 845.3 0.3 2e-254 844.7 0.2 1.3 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.14 CDF87476.1 - 5.1e-60 201.2 0.0 1.6e-59 199.5 0.0 1.9 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.18 CDF87476.1 - 1.8e-38 131.1 0.4 4.5e-38 129.8 0.3 1.7 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain AdoHcyase_NAD PF00670.16 CDF87476.1 - 0.03 14.1 0.1 1.7 8.4 0.0 2.8 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain MAF_flag10 PF01973.13 CDF87476.1 - 0.041 13.4 0.0 0.28 10.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF115 GTP_EFTU PF00009.22 CDF87476.1 - 0.12 11.7 0.6 0.26 10.7 0.0 1.8 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_17 PF13207.1 CDF87477.1 - 3.9e-05 24.4 0.1 7.2e-05 23.6 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDF87477.1 - 0.00081 19.4 0.0 0.0013 18.7 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 CDF87477.1 - 0.0017 18.4 0.0 0.0026 17.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CDF87477.1 - 0.0023 17.6 0.1 0.0056 16.4 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain Zeta_toxin PF06414.7 CDF87477.1 - 0.0024 17.0 0.0 0.0034 16.5 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin NTPase_1 PF03266.10 CDF87477.1 - 0.0066 16.1 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 NTPase T2SE PF00437.15 CDF87477.1 - 0.016 14.1 0.0 0.022 13.6 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA PF00004.24 CDF87477.1 - 0.02 15.0 0.0 0.031 14.4 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 CDF87477.1 - 0.023 14.8 0.0 0.044 13.9 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_10 PF12846.2 CDF87477.1 - 0.024 14.0 0.1 0.037 13.4 0.1 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_18 PF13238.1 CDF87477.1 - 0.031 14.5 0.0 0.074 13.3 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.1 CDF87477.1 - 0.037 13.9 0.0 0.068 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 CDF87477.1 - 0.048 13.3 0.0 0.085 12.5 0.0 1.4 1 0 0 1 1 1 0 Archaeal ATPase DUF2551 PF10826.3 CDF87477.1 - 0.061 13.2 0.0 0.21 11.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2551) AAA_33 PF13671.1 CDF87477.1 - 0.067 13.0 0.0 0.099 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.1 CDF87477.1 - 0.068 12.7 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain PIF1 PF05970.9 CDF87477.1 - 0.068 12.0 0.1 0.1 11.4 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase SRP54 PF00448.17 CDF87477.1 - 0.084 12.3 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain PRK PF00485.13 CDF87477.1 - 0.096 12.2 0.0 0.88 9.0 0.0 2.0 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family NACHT PF05729.7 CDF87477.1 - 0.11 12.1 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 NACHT domain MobB PF03205.9 CDF87477.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Sigma54_activ_2 PF14532.1 CDF87477.1 - 0.15 12.1 0.0 0.24 11.4 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain LSM PF01423.17 CDF87479.1 - 7.6e-11 41.3 0.1 1.7e-10 40.2 0.1 1.6 1 1 0 1 1 1 1 LSM domain Aldolase_II PF00596.16 CDF87480.1 - 1.2e-38 132.5 0.0 1.4e-38 132.3 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain 3-HAO PF06052.7 CDF87481.1 - 6.6e-65 217.1 0.0 7.6e-65 216.9 0.0 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.6 CDF87481.1 - 0.00012 21.5 0.0 0.0002 20.7 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Nudix_N_2 PF14803.1 CDF87481.1 - 0.0018 17.9 0.5 1.1 9.0 0.1 2.7 2 0 0 2 2 2 2 Nudix N-terminal ADK_lid PF05191.9 CDF87481.1 - 0.03 13.9 0.7 0.18 11.4 0.2 2.5 2 1 0 2 2 2 0 Adenylate kinase, active site lid Cupin_1 PF00190.17 CDF87481.1 - 0.036 13.5 0.0 0.049 13.0 0.0 1.2 1 0 0 1 1 1 0 Cupin GFA PF04828.9 CDF87481.1 - 0.048 13.6 0.3 12 5.9 0.0 2.3 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme DZR PF12773.2 CDF87481.1 - 0.1 12.4 1.5 0.34 10.7 0.7 2.1 2 1 0 2 2 2 0 Double zinc ribbon Rpr2 PF04032.11 CDF87481.1 - 0.15 11.9 0.9 0.7 9.8 0.7 1.9 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-ribbon_3 PF13248.1 CDF87481.1 - 0.72 9.1 3.8 13 5.1 0.1 2.7 3 0 0 3 3 3 0 zinc-ribbon domain Mvb12 PF09452.5 CDF87482.1 - 1.9e-24 85.6 0.0 2.2e-24 85.4 0.0 1.0 1 0 0 1 1 1 1 ESCRT-I subunit Mvb12 ETF PF01012.16 CDF87483.1 - 2.2e-34 118.5 0.2 2.7e-34 118.2 0.2 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain DUP PF00674.13 CDF87484.1 - 5.3e-05 23.1 1.5 9.5e-05 22.3 1.1 1.6 1 1 0 1 1 1 1 DUP family Myb_DNA-bind_6 PF13921.1 CDF87484.1 - 0.12 12.4 0.1 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Myb-like DNA-binding domain TGS PF02824.16 CDF87485.1 - 1.7e-19 69.3 0.0 4.1e-19 68.1 0.0 1.7 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.18 CDF87485.1 - 9.2e-19 67.5 0.3 4.8e-18 65.2 0.0 2.0 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 CDF87485.1 - 1.4e-13 50.4 0.0 2.4e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 CDF87485.1 - 0.00033 20.5 0.7 0.064 13.0 0.0 2.4 1 1 1 2 2 2 2 Dynamin family Miro PF08477.8 CDF87485.1 - 0.0015 19.0 0.2 0.0044 17.5 0.0 2.0 2 1 0 2 2 2 1 Miro-like protein MCM PF00493.18 CDF87485.1 - 0.0073 15.1 0.0 0.016 13.9 0.0 1.5 1 0 0 1 1 1 1 MCM2/3/5 family AIG1 PF04548.11 CDF87485.1 - 0.021 13.9 0.1 0.035 13.2 0.0 1.3 1 0 0 1 1 1 0 AIG1 family SRPRB PF09439.5 CDF87485.1 - 0.022 13.9 0.4 0.089 12.0 0.0 2.0 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit Enkurin PF13864.1 CDF87487.1 - 0.057 13.6 0.1 0.14 12.3 0.0 1.6 2 0 0 2 2 2 0 Calmodulin-binding Abhydrolase_6 PF12697.2 CDF87488.1 - 9e-20 71.5 0.0 1.3e-19 71.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CDF87488.1 - 1.8e-07 30.9 0.0 2.1e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDF87488.1 - 5.8e-06 26.0 0.0 1.5e-05 24.6 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.8 CDF87488.1 - 1.5e-05 24.7 0.0 2.9e-05 23.7 0.0 1.4 2 0 0 2 2 2 1 PGAP1-like protein Thioesterase PF00975.15 CDF87488.1 - 0.00031 21.0 0.0 0.00046 20.4 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Hydrolase_4 PF12146.3 CDF87488.1 - 0.0048 16.7 0.0 0.0082 15.9 0.0 1.3 1 0 0 1 1 1 1 Putative lysophospholipase DLH PF01738.13 CDF87488.1 - 0.017 14.4 0.0 0.36 10.0 0.0 2.1 1 1 0 1 1 1 0 Dienelactone hydrolase family HR1 PF02185.11 CDF87488.1 - 0.13 12.0 0.2 0.22 11.2 0.1 1.3 1 0 0 1 1 1 0 Hr1 repeat Lipase_3 PF01764.20 CDF87488.1 - 0.16 11.6 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) PWI PF01480.12 CDF87490.1 - 0.0097 15.9 0.2 0.043 13.9 0.1 2.1 1 0 0 1 1 1 1 PWI domain Pox_Ag35 PF03286.9 CDF87490.1 - 1.1 8.7 21.1 0.011 15.2 5.3 2.4 2 0 0 2 2 2 0 Pox virus Ag35 surface protein PALP PF00291.20 CDF87491.1 - 1.4e-61 208.4 0.3 1.6e-61 208.2 0.2 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme GYD PF08734.6 CDF87491.1 - 0.15 11.7 1.7 0.76 9.5 0.1 2.5 3 0 0 3 3 3 0 GYD domain CTP_transf_2 PF01467.21 CDF87493.1 - 3e-35 121.6 0.0 6.1e-35 120.5 0.0 1.5 1 0 0 1 1 1 1 Cytidylyltransferase HABP4_PAI-RBP1 PF04774.10 CDF87494.1 - 2.7e-05 24.6 0.9 3.6e-05 24.1 0.6 1.2 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family CTP_transf_2 PF01467.21 CDF87495.1 - 1.6e-13 50.9 0.3 7.7e-12 45.5 0.0 2.5 2 1 0 2 2 2 1 Cytidylyltransferase FAD_syn PF06574.7 CDF87495.1 - 0.0087 15.6 0.2 3.1 7.3 0.0 2.8 3 0 0 3 3 3 2 FAD synthetase DUF4112 PF13430.1 CDF87496.1 - 2.4e-32 111.0 0.3 3.2e-32 110.6 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) Prp18 PF02840.10 CDF87497.1 - 5.6e-40 136.5 1.3 1.3e-39 135.2 0.0 2.2 1 1 0 2 2 2 1 Prp18 domain TFIIF_beta PF02270.10 CDF87498.1 - 2e-95 319.7 13.0 2.6e-95 319.3 9.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, beta subunit DUF2252 PF10009.4 CDF87498.1 - 0.095 11.5 5.3 0.03 13.2 1.9 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2252) IncA PF04156.9 CDF87498.1 - 2.8 7.5 10.2 5.9 6.4 7.1 1.5 1 0 0 1 1 1 0 IncA protein Ribosomal_L38e PF01781.13 CDF87499.1 - 5.3e-29 99.7 2.5 6e-29 99.5 1.8 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family Arena_nucleocap PF00843.12 CDF87499.1 - 0.052 11.4 0.1 0.052 11.4 0.0 1.1 1 0 0 1 1 1 0 Arenavirus nucleocapsid protein Pex24p PF06398.6 CDF87500.1 - 8.5e-90 301.1 10.9 1.3e-89 300.4 7.6 1.3 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin zf-CCCH PF00642.19 CDF87501.1 - 9.1e-10 37.9 2.7 2.2e-09 36.7 1.9 1.7 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.1 CDF87501.1 - 1.6e-09 37.2 6.4 2.8e-09 36.5 4.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDF87501.1 - 1.8e-09 37.4 10.5 3.5e-09 36.5 7.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CDF87501.1 - 1.7e-08 34.1 7.2 3.3e-08 33.2 5.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 CDF87501.1 - 2e-08 33.7 9.7 4e-08 32.8 6.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 CDF87501.1 - 1.2e-07 31.2 9.8 2.2e-07 30.3 6.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 CDF87501.1 - 8e-05 22.2 3.2 0.00018 21.1 0.7 2.6 1 1 1 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.1 CDF87501.1 - 9.5e-05 21.8 8.0 0.0002 20.8 5.5 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.1 CDF87501.1 - 0.0001 22.1 7.0 0.00026 20.8 4.9 1.7 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.2 CDF87501.1 - 0.00086 19.3 5.8 0.0028 17.7 4.1 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger zf-RING_6 PF14835.1 CDF87501.1 - 0.0057 16.4 4.7 0.01 15.6 3.3 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein PolC_DP2 PF03833.8 CDF87501.1 - 0.015 12.9 2.0 0.02 12.5 1.4 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-P11 PF03854.9 CDF87501.1 - 0.016 14.6 2.8 0.037 13.4 2.0 1.6 1 0 0 1 1 1 0 P-11 zinc finger zf-Nse PF11789.3 CDF87501.1 - 0.076 12.5 5.5 0.083 12.4 2.9 1.8 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.1 CDF87501.1 - 0.12 11.9 7.3 0.14 11.7 2.4 2.4 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-MIZ PF02891.15 CDF87501.1 - 2 7.9 6.3 4.9 6.7 4.4 1.7 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-FCS PF06467.9 CDF87501.1 - 2 8.0 10.1 3.1 7.5 4.4 2.7 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Cullin PF00888.17 CDF87502.1 - 2.3e-100 336.8 30.7 2.9e-100 336.5 21.3 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.4 CDF87502.1 - 1.7e-20 72.6 0.1 6.8e-20 70.6 0.1 2.2 1 0 0 1 1 1 1 Cullin protein neddylation domain TrmB PF01978.14 CDF87502.1 - 0.0013 18.3 0.0 0.31 10.7 0.0 2.6 2 0 0 2 2 2 2 Sugar-specific transcriptional regulator TrmB Myb_DNA-bind_6 PF13921.1 CDF87503.1 - 6.8e-06 26.0 0.8 2.5e-05 24.3 0.6 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 CDF87503.1 - 6.7e-05 22.8 0.2 0.00018 21.4 0.1 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain E_Pc_C PF06752.7 CDF87503.1 - 0.16 11.4 4.8 0.27 10.6 3.3 1.3 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus Mus7 PF09462.5 CDF87504.1 - 5.6e-22 78.3 14.6 1.5e-17 63.7 2.8 2.4 2 0 0 2 2 2 2 Mus7/MMS22 family AIP3 PF03915.8 CDF87505.1 - 3.6e-145 484.1 22.0 3.6e-145 484.1 15.3 2.0 2 0 0 2 2 2 1 Actin interacting protein 3 ATP-synt_D PF01813.12 CDF87505.1 - 0.032 13.7 10.7 0.024 14.2 4.4 2.3 1 1 1 2 2 2 0 ATP synthase subunit D Telomerase_RBD PF12009.3 CDF87506.1 - 6e-28 97.4 4.1 2.4e-27 95.4 2.9 2.1 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.22 CDF87506.1 - 5.5e-09 35.6 0.5 5.9e-08 32.3 0.4 2.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) dCMP_cyt_deam_1 PF00383.17 CDF87507.1 - 7e-08 32.0 0.1 1.2e-07 31.2 0.1 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region CENP-I PF07778.6 CDF87508.1 - 0.0024 16.1 1.3 0.0028 15.9 0.9 1.1 1 0 0 1 1 1 1 Mis6 PUB PF09409.5 CDF87508.1 - 0.022 14.5 0.3 0.08 12.7 0.2 1.9 2 0 0 2 2 2 0 PUB domain Cnl2_NKP2 PF09447.5 CDF87508.1 - 0.025 14.2 2.5 0.043 13.4 0.6 2.3 2 1 0 2 2 2 0 Cnl2/NKP2 family protein Poty_PP PF08440.5 CDF87508.1 - 0.78 8.7 4.4 0.36 9.8 1.7 1.4 2 0 0 2 2 2 0 Potyviridae polyprotein DUF4200 PF13863.1 CDF87508.1 - 1.5 8.8 14.1 1.2 9.1 6.8 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) SNF5 PF04855.7 CDF87509.1 - 1.2e-64 218.1 0.9 1.2e-37 129.6 0.0 2.2 1 1 1 2 2 2 2 SNF5 / SMARCB1 / INI1 Ig_3 PF13927.1 CDF87509.1 - 0.065 13.7 0.4 2.5 8.6 0.0 2.6 1 1 1 2 2 2 0 Immunoglobulin domain Ig_2 PF13895.1 CDF87509.1 - 0.093 12.8 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain EF1_GNE PF00736.14 CDF87510.1 - 1.4e-30 104.8 1.9 2.6e-30 103.9 1.3 1.4 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.4 CDF87510.1 - 1.5e-13 50.6 6.4 1.5e-13 50.6 4.4 2.6 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region Cwf_Cwc_15 PF04889.7 CDF87510.1 - 0.0079 15.9 2.0 0.014 15.1 1.4 1.4 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein DNA_pol3_a_NII PF11490.3 CDF87510.1 - 3.5 7.2 8.3 6.1 6.4 0.1 2.4 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II Vps8 PF12816.2 CDF87511.1 - 5.1e-61 205.3 1.4 5.1e-61 205.3 1.0 2.4 2 0 0 2 2 2 1 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.15 CDF87511.1 - 6.8e-06 25.7 8.9 0.0016 18.0 1.5 3.2 3 0 0 3 3 3 2 Region in Clathrin and VPS zf-C3HC4 PF00097.20 CDF87511.1 - 0.02 14.5 3.5 0.067 12.8 2.4 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 CDF87511.1 - 0.032 14.3 7.8 0.063 13.4 3.9 2.6 2 1 0 2 2 2 0 RING-H2 zinc finger PHD PF00628.24 CDF87511.1 - 0.093 12.4 3.6 0.26 11.0 2.5 1.8 1 0 0 1 1 1 0 PHD-finger zf-RING_2 PF13639.1 CDF87511.1 - 0.15 11.9 8.8 0.073 12.9 2.4 2.8 3 0 0 3 3 3 0 Ring finger domain zf-RING_UBOX PF13445.1 CDF87511.1 - 0.37 10.5 2.2 0.93 9.2 1.2 1.9 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_5 PF14634.1 CDF87511.1 - 2.8 7.7 9.1 12 5.7 6.4 2.1 1 1 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CDF87511.1 - 3.1 7.9 8.4 0.22 11.5 1.8 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) B-block_TFIIIC PF04182.7 CDF87512.1 - 2.1e-15 56.3 0.1 2.8e-14 52.7 0.0 2.8 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC RPA_C PF08784.6 CDF87512.1 - 0.07 13.5 0.3 3.8 7.9 0.0 3.9 5 0 0 5 5 5 0 Replication protein A C terminal N6-adenineMlase PF10237.4 CDF87513.1 - 3.9e-57 192.4 0.2 6.3e-57 191.7 0.1 1.3 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase GDE_C PF06202.9 CDF87513.1 - 0.092 11.4 0.3 0.14 10.8 0.2 1.4 1 0 0 1 1 1 0 Amylo-alpha-1,6-glucosidase Latarcin PF10279.4 CDF87513.1 - 0.15 12.2 3.9 0.31 11.2 2.7 1.5 1 0 0 1 1 1 0 Latarcin precursor IncA PF04156.9 CDF87513.1 - 0.34 10.4 6.2 0.51 9.9 4.3 1.3 1 0 0 1 1 1 0 IncA protein 3Beta_HSD PF01073.14 CDF87514.1 - 8.2e-83 277.3 0.0 1e-82 277.0 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 CDF87514.1 - 1.5e-29 103.1 0.0 2e-29 102.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 CDF87514.1 - 1.2e-14 53.9 0.0 1.2e-13 50.5 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.12 CDF87514.1 - 1.3e-11 43.9 0.0 2.4e-11 43.0 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.1 CDF87514.1 - 1.3e-07 31.7 0.0 2e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 CDF87514.1 - 1.5e-06 27.2 0.0 3e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.20 CDF87514.1 - 5.6e-05 23.1 0.0 0.00022 21.1 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.8 CDF87514.1 - 0.0007 18.9 0.0 0.00099 18.4 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family KR PF08659.5 CDF87514.1 - 0.0023 17.6 0.0 0.0092 15.6 0.0 1.9 1 1 0 1 1 1 1 KR domain EMP24_GP25L PF01105.19 CDF87516.1 - 9.4e-49 165.6 1.3 1.2e-48 165.3 0.9 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF4353 PF14262.1 CDF87516.1 - 0.061 12.5 0.0 0.08 12.1 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4353) Crinivirus_P26 PF07416.6 CDF87516.1 - 0.27 10.7 2.7 3 7.2 0.1 2.1 1 1 0 2 2 2 0 Crinivirus P26 protein WD40 PF00400.27 CDF87517.1 - 3.1e-20 71.2 4.7 1.4e-10 40.6 0.1 5.0 5 0 0 5 5 5 4 WD domain, G-beta repeat eIF2A PF08662.6 CDF87517.1 - 0.0003 20.5 0.3 0.059 13.0 0.0 2.8 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Apc4_WD40 PF12894.2 CDF87517.1 - 0.018 14.5 0.0 8 6.0 0.0 3.3 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.27 CDF87518.1 - 2.8e-30 103.0 0.2 9.3e-06 25.3 0.0 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat eIF2A PF08662.6 CDF87518.1 - 2.6e-06 27.2 0.3 0.0038 16.9 0.1 3.1 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Zn_clus PF00172.13 CDF87519.1 - 0.00017 21.3 10.7 0.00034 20.4 7.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CDF87519.1 - 0.0012 17.8 1.0 0.0023 16.8 0.7 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Rep_fac-A_C PF08646.5 CDF87520.1 - 5.2e-60 201.3 1.1 2.7e-56 189.3 0.5 2.4 2 0 0 2 2 2 2 Replication factor-A C terminal domain tRNA_anti-codon PF01336.20 CDF87520.1 - 2.1e-13 49.9 0.4 1.5e-07 31.1 0.0 4.4 4 0 0 4 4 4 2 OB-fold nucleic acid binding domain Rep-A_N PF04057.7 CDF87520.1 - 2.6e-06 27.1 0.1 7.4e-06 25.6 0.1 1.8 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain BRCA-2_OB1 PF09103.5 CDF87520.1 - 0.031 13.9 0.0 0.093 12.4 0.0 1.7 1 0 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 WD40 PF00400.27 CDF87521.1 - 4.1e-16 58.1 0.1 6.3e-07 29.0 0.0 3.7 3 0 0 3 3 3 2 WD domain, G-beta repeat eIF2A PF08662.6 CDF87521.1 - 0.046 13.4 0.0 1.3 8.7 0.0 2.4 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A IR1-M PF12185.3 CDF87521.1 - 0.054 13.2 0.3 0.25 11.0 0.4 1.9 2 0 0 2 2 2 0 Nup358/RanBP2 E3 ligase domain Peptidase_M13_N PF05649.8 CDF87522.1 - 0.03 13.3 1.2 0.041 12.9 0.8 1.2 1 0 0 1 1 1 0 Peptidase family M13 LAP2alpha PF11560.3 CDF87522.1 - 0.058 12.5 0.1 0.094 11.8 0.1 1.4 1 0 0 1 1 1 0 Lamina-associated polypeptide 2 alpha Imm46 PF15585.1 CDF87522.1 - 0.063 13.3 0.1 0.36 10.8 0.0 2.2 2 1 1 3 3 3 0 Immunity protein 46 Reo_sigmaC PF04582.7 CDF87522.1 - 0.35 9.9 9.7 0.34 10.0 1.8 2.1 1 1 1 2 2 2 0 Reovirus sigma C capsid protein Fib_alpha PF08702.5 CDF87522.1 - 1.9 8.5 8.3 9 6.4 1.9 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family E1-E2_ATPase PF00122.15 CDF87523.1 - 1.5e-61 207.3 0.6 1.5e-61 207.3 0.4 2.3 2 1 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 CDF87523.1 - 1.1e-36 126.0 2.7 1.1e-36 126.0 1.9 2.6 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CDF87523.1 - 8.9e-24 85.0 0.0 6.8e-23 82.2 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CDF87523.1 - 2.1e-13 49.9 0.0 5.6e-13 48.6 0.0 1.8 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 CDF87523.1 - 4.7e-11 43.1 0.0 1.6e-10 41.4 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 CDF87523.1 - 2.7e-10 39.5 0.0 1.1e-09 37.6 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 CDF87523.1 - 6.4e-06 25.9 2.2 0.00016 21.3 0.6 2.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3325 PF11804.3 CDF87523.1 - 0.004 17.0 0.8 0.011 15.7 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3325) tRNA_int_endo PF01974.12 CDF87524.1 - 1.8e-18 66.0 0.0 3.4e-18 65.2 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain ADH_N PF08240.7 CDF87525.1 - 7.5e-20 70.7 8.2 1.4e-19 69.8 5.7 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CDF87525.1 - 7.4e-15 54.6 0.0 1.7e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 CDF87525.1 - 4.6e-06 25.9 0.0 7.6e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.16 CDF87525.1 - 0.00048 19.7 0.1 0.0008 19.0 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_10 PF13460.1 CDF87525.1 - 0.0024 17.8 0.1 0.0041 17.1 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding NAD_binding_2 PF03446.10 CDF87525.1 - 0.028 14.2 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.13 CDF87525.1 - 0.26 10.9 1.5 0.45 10.1 1.0 1.5 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain E1-E2_ATPase PF00122.15 CDF87526.1 - 9.3e-62 208.0 4.1 1.8e-61 207.1 2.8 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 CDF87526.1 - 4.2e-24 86.1 0.0 9.3e-24 85.0 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 CDF87526.1 - 2e-14 54.1 0.0 6.4e-14 52.5 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 CDF87526.1 - 5.4e-11 41.7 0.8 1.2e-10 40.6 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 CDF87526.1 - 0.0026 17.3 0.1 0.0026 17.3 0.1 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CDF87526.1 - 0.024 14.5 0.0 0.047 13.6 0.0 1.4 1 0 0 1 1 1 0 Putative hydrolase of sodium-potassium ATPase alpha subunit PUF PF00806.14 CDF87527.1 - 9.6e-60 194.8 11.2 1.9e-08 33.3 0.2 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Fungal_trans PF04082.13 CDF87528.1 - 6.9e-36 123.4 5.7 1.3e-35 122.5 4.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF87528.1 - 3.9e-10 39.4 12.8 8.3e-10 38.4 8.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain dTMP_synthase PF02593.9 CDF87529.1 - 0.25 10.6 3.2 11 5.2 0.0 2.7 3 0 0 3 3 3 0 Thymidylate synthase ERG4_ERG24 PF01222.12 CDF87530.1 - 9e-178 591.2 32.9 1e-177 591.0 22.8 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family CytoC_RC PF02276.13 CDF87530.1 - 0.014 14.5 0.0 0.02 14.0 0.0 1.1 1 0 0 1 1 1 0 Photosynthetic reaction centre cytochrome C subunit Rsc14 PF08586.5 CDF87531.1 - 8e-37 125.7 0.1 1.1e-36 125.3 0.1 1.2 1 0 0 1 1 1 1 RSC complex, Rsc14/Ldb7 subunit zf-BED PF02892.10 CDF87531.1 - 0.019 14.6 2.3 0.037 13.7 1.6 1.4 1 0 0 1 1 1 0 BED zinc finger zf-AN1 PF01428.11 CDF87531.1 - 0.036 13.9 2.3 0.088 12.6 1.6 1.7 1 0 0 1 1 1 0 AN1-like Zinc finger Zn_ribbon_recom PF13408.1 CDF87531.1 - 0.83 9.9 4.9 5.8 7.2 3.3 2.2 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain Proteasome PF00227.21 CDF87532.1 - 1.8e-42 144.7 0.0 2.7e-42 144.2 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 CDF87532.1 - 3.1e-15 55.1 1.4 3.4e-15 55.0 0.1 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature DUF962 PF06127.6 CDF87533.1 - 9.7e-26 89.5 3.5 3.3e-25 87.7 2.4 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF962) Bromo_MP PF01573.11 CDF87533.1 - 0.13 11.2 0.1 0.18 10.7 0.1 1.2 1 0 0 1 1 1 0 Bromovirus movement protein SH3_1 PF00018.23 CDF87534.1 - 5.6e-37 124.9 6.3 1.7e-13 49.7 0.1 4.2 4 0 0 4 4 4 3 SH3 domain SH3_9 PF14604.1 CDF87534.1 - 2.4e-35 119.8 7.3 1.1e-12 47.2 0.2 4.1 4 0 0 4 4 4 3 Variant SH3 domain SHD1 PF03983.7 CDF87534.1 - 3.8e-33 112.9 0.0 7.4e-33 112.0 0.0 1.5 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_2 PF07653.12 CDF87534.1 - 7.3e-31 105.4 0.0 4.5e-10 38.8 0.0 4.6 4 0 0 4 4 4 4 Variant SH3 domain DUF3104 PF11302.3 CDF87534.1 - 0.079 12.3 0.1 0.079 12.3 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3104) Aconitase PF00330.15 CDF87535.1 - 2.1e-190 633.1 0.3 2.6e-190 632.8 0.2 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 CDF87535.1 - 1.1e-48 164.6 0.0 2.2e-48 163.6 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain WD40 PF00400.27 CDF87536.1 - 1.3e-42 142.1 13.5 1.1e-11 44.0 0.1 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat Hira PF07569.6 CDF87536.1 - 7.6e-09 35.1 0.0 1.4e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 TUP1-like enhancer of split HIRA_B PF09453.5 CDF87536.1 - 2.4e-08 33.3 0.1 8.5e-08 31.5 0.1 2.0 1 0 0 1 1 1 1 HIRA B motif PD40 PF07676.7 CDF87536.1 - 0.00023 20.7 1.7 1.3 8.7 0.0 4.6 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.1 CDF87536.1 - 0.00075 18.6 0.0 0.0017 17.5 0.0 1.6 1 0 0 1 1 1 1 Neuroblastoma-amplified sequence, N terminal eIF2A PF08662.6 CDF87536.1 - 0.00088 19.0 0.0 0.95 9.1 0.0 4.3 4 1 0 4 4 4 1 Eukaryotic translation initiation factor eIF2A ATE_C PF04377.10 CDF87538.1 - 7.4e-43 145.6 1.2 1.6e-42 144.5 0.8 1.6 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.8 CDF87538.1 - 2.4e-24 84.9 3.5 6.2e-24 83.6 2.4 1.8 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus HSCB_C PF07743.8 CDF87539.1 - 1.7e-19 70.0 5.1 3.9e-19 68.8 3.0 1.9 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.26 CDF87539.1 - 6.5e-11 41.8 0.0 1.3e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain UVR PF02151.14 CDF87539.1 - 0.033 13.7 0.3 0.1 12.1 0.2 1.8 1 0 0 1 1 1 0 UvrB/uvrC motif Cortex-I_coil PF09304.5 CDF87539.1 - 1.1 9.2 7.3 0.37 10.8 3.2 1.7 2 1 0 2 2 2 0 Cortexillin I, coiled coil CK_II_beta PF01214.13 CDF87540.1 - 8.3e-72 240.5 0.2 1.2e-71 240.0 0.1 1.2 1 0 0 1 1 1 1 Casein kinase II regulatory subunit CHD5 PF04420.9 CDF87541.1 - 1.4e-43 148.3 2.3 1.8e-43 148.0 1.6 1.1 1 0 0 1 1 1 1 CHD5-like protein DUF4094 PF13334.1 CDF87541.1 - 0.017 15.4 3.0 0.045 14.1 1.8 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) DUF1049 PF06305.6 CDF87541.1 - 0.093 12.2 0.9 0.3 10.5 0.6 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) IncA PF04156.9 CDF87541.1 - 1 8.8 4.1 1.5 8.3 2.9 1.2 1 0 0 1 1 1 0 IncA protein OmpH PF03938.9 CDF87541.1 - 1.2 9.0 4.4 2 8.3 3.1 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF3635 PF12330.3 CDF87542.1 - 6.9e-20 70.9 0.0 2.2e-19 69.3 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3635) STT3 PF02516.9 CDF87544.1 - 8.1e-137 457.0 46.8 1.4e-136 456.3 32.4 1.3 1 1 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit Peptidase_M50 PF02163.17 CDF87544.1 - 0.64 8.9 4.1 3.8 6.4 1.6 3.0 1 1 0 1 1 1 0 Peptidase family M50 CRCB PF02537.10 CDF87547.1 - 1.1e-28 99.4 18.6 5.3e-17 61.7 5.3 2.7 2 1 0 2 2 2 2 CrcB-like protein Formyl_trans_N PF00551.14 CDF87549.1 - 2e-31 108.9 0.0 4.8e-31 107.6 0.0 1.6 2 0 0 2 2 2 1 Formyl transferase Formyl_trans_C PF02911.13 CDF87549.1 - 2.9e-08 33.7 0.0 5.9e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain Stk19 PF10494.4 CDF87550.1 - 0.087 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Serine-threonine protein kinase 19 Med3 PF11593.3 CDF87551.1 - 1.1e-44 153.1 56.1 1.1e-44 153.1 38.9 6.9 1 1 4 5 5 5 2 Mediator complex subunit 3 fungal Trp_syntA PF00290.15 CDF87552.1 - 1.8e-94 315.1 0.2 2.6e-94 314.5 0.1 1.2 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.20 CDF87552.1 - 2.9e-45 154.8 1.4 1.6e-44 152.4 0.3 2.1 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Rrn6 PF10214.4 CDF87553.1 - 1.2e-123 413.8 24.6 1.4e-123 413.6 17.1 1.0 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor Glyco_hydro_63 PF03200.11 CDF87554.1 - 2.9e-220 733.2 3.9 2.2e-219 730.3 2.7 1.8 1 1 0 1 1 1 1 Mannosyl oligosaccharide glucosidase Glyco_hydro_17 PF00332.13 CDF87555.1 - 7.9e-08 31.6 0.2 0.00016 20.8 0.0 2.3 2 0 0 2 2 2 2 Glycosyl hydrolases family 17 DUF706 PF05153.10 CDF87556.1 - 1.7e-122 407.5 9.5 2.1e-122 407.2 6.6 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF706) HD PF01966.17 CDF87556.1 - 0.0057 16.6 4.5 0.8 9.7 0.0 3.4 2 1 0 3 3 3 1 HD domain AlkA_N PF06029.6 CDF87556.1 - 0.078 13.0 0.1 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 AlkA N-terminal domain SinI PF08671.5 CDF87556.1 - 0.49 9.8 0.0 0.49 9.8 0.0 2.1 2 0 0 2 2 2 0 Anti-repressor SinI Methyltransf_18 PF12847.2 CDF87557.1 - 0.0058 17.1 0.1 0.12 12.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDF87557.1 - 0.0076 16.7 0.0 0.022 15.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Sod_Fe_C PF02777.13 CDF87558.1 - 1.9e-36 124.1 0.5 3.5e-36 123.2 0.4 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 CDF87558.1 - 1.9e-24 85.7 0.1 3.7e-24 84.7 0.1 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Pkinase PF00069.20 CDF87559.1 - 2e-62 210.7 0.0 2.9e-62 210.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF87559.1 - 9.3e-35 119.9 0.0 1.5e-34 119.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF87559.1 - 5e-09 35.5 0.0 8.6e-09 34.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CDF87559.1 - 3e-05 23.8 0.6 9.1e-05 22.3 0.2 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.17 CDF87559.1 - 0.02 14.2 0.1 0.039 13.3 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.9 CDF87559.1 - 0.065 12.2 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SNARE PF05739.14 CDF87560.1 - 5.5e-14 51.5 4.1 5.5e-14 51.5 2.9 2.3 2 0 0 2 2 2 1 SNARE domain Myosin_tail_1 PF01576.14 CDF87560.1 - 8.9e-05 20.4 7.3 0.00012 20.0 5.0 1.1 1 0 0 1 1 1 1 Myosin tail Syntaxin-6_N PF09177.6 CDF87560.1 - 0.00019 21.7 1.6 0.00019 21.7 1.1 3.0 1 1 1 2 2 2 1 Syntaxin 6, N-terminal RmuC PF02646.11 CDF87560.1 - 0.0034 16.2 5.8 0.097 11.4 0.3 2.1 2 0 0 2 2 2 2 RmuC family HisKA_3 PF07730.8 CDF87560.1 - 0.0037 17.5 3.2 0.16 12.3 0.2 2.5 2 0 0 2 2 2 1 Histidine kinase TMCO5 PF14992.1 CDF87560.1 - 0.0042 16.2 5.3 0.006 15.7 3.7 1.2 1 0 0 1 1 1 1 TMCO5 family DUF745 PF05335.8 CDF87560.1 - 0.013 15.0 5.4 0.11 11.9 0.5 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF745) DUF4164 PF13747.1 CDF87560.1 - 0.053 13.6 1.5 0.053 13.6 1.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) Microtub_assoc PF07989.6 CDF87560.1 - 0.06 13.1 4.1 0.39 10.5 0.5 2.5 2 0 0 2 2 2 0 Microtubule associated Sec20 PF03908.8 CDF87560.1 - 0.23 11.1 1.3 0.4 10.4 0.1 1.8 2 0 0 2 2 2 0 Sec20 PilJ PF13675.1 CDF87560.1 - 0.29 11.4 6.4 0.33 11.2 0.4 2.3 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term RasGAP_C PF03836.10 CDF87560.1 - 0.34 10.6 5.4 2.4 7.8 0.4 2.6 2 1 0 2 2 2 0 RasGAP C-terminus Dpy-30 PF05186.8 CDF87561.1 - 1.9e-16 59.2 0.0 2.4e-16 58.9 0.0 1.1 1 0 0 1 1 1 1 Dpy-30 motif RmuC PF02646.11 CDF87562.1 - 0.0013 17.6 6.5 0.047 12.5 0.2 2.2 2 0 0 2 2 2 2 RmuC family BAR PF03114.13 CDF87562.1 - 0.007 15.8 9.4 0.013 15.0 2.9 2.1 1 1 1 2 2 2 1 BAR domain Tropomyosin PF00261.15 CDF87562.1 - 0.0076 15.3 10.0 0.011 14.7 7.0 1.2 1 0 0 1 1 1 1 Tropomyosin MCPsignal PF00015.16 CDF87562.1 - 0.0086 15.6 2.4 0.0086 15.6 1.7 2.0 1 1 2 3 3 3 1 Methyl-accepting chemotaxis protein (MCP) signalling domain YkuI_C PF10388.4 CDF87562.1 - 0.026 14.1 0.5 0.026 14.1 0.3 2.1 2 0 0 2 2 2 0 EAL-domain associated signalling protein domain Muted PF14942.1 CDF87562.1 - 0.054 13.3 10.2 0.026 14.4 4.4 2.2 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein GrpE PF01025.14 CDF87562.1 - 0.077 12.5 12.2 0.52 9.8 4.3 2.3 1 1 1 2 2 2 0 GrpE Spc7 PF08317.6 CDF87562.1 - 0.15 10.7 9.5 0.21 10.2 6.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein GAS PF13851.1 CDF87562.1 - 0.17 11.0 15.5 0.84 8.7 4.7 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding TMF_TATA_bd PF12325.3 CDF87562.1 - 0.29 10.8 14.9 1.5 8.5 5.6 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF775 PF05603.7 CDF87562.1 - 0.3 10.5 1.6 0.42 10.1 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF775) ATG16 PF08614.6 CDF87562.1 - 0.49 10.1 14.3 0.27 11.0 8.1 1.8 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Tropomyosin_1 PF12718.2 CDF87562.1 - 0.58 10.0 14.4 0.58 10.0 8.2 2.0 1 1 1 2 2 2 0 Tropomyosin like Vps5 PF09325.5 CDF87562.1 - 0.59 9.3 11.0 0.088 12.0 3.9 1.9 1 1 0 2 2 2 0 Vps5 C terminal like CENP-F_leu_zip PF10473.4 CDF87562.1 - 0.69 9.7 14.8 3.7 7.4 10.3 2.0 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 YicC_N PF03755.8 CDF87562.1 - 0.74 9.7 7.7 0.69 9.8 4.0 1.7 1 1 1 2 2 2 0 YicC-like family, N-terminal region DUF465 PF04325.8 CDF87562.1 - 0.88 9.3 5.3 6.5 6.5 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF465) IFT46_B_C PF12317.3 CDF87562.1 - 1 8.7 5.3 6.6 6.0 1.0 2.1 1 1 1 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal Bap31 PF05529.7 CDF87562.1 - 1.2 8.6 6.2 0.53 9.7 1.4 2.0 2 0 0 2 2 2 0 B-cell receptor-associated protein 31-like Mnd1 PF03962.10 CDF87562.1 - 1.2 8.7 12.2 1.7 8.3 4.7 2.1 1 1 1 2 2 2 0 Mnd1 family Seryl_tRNA_N PF02403.17 CDF87562.1 - 1.2 9.1 7.6 6.4 6.8 0.4 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain V_ATPase_I PF01496.14 CDF87562.1 - 1.7 6.3 7.0 2.1 6.1 4.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family IncA PF04156.9 CDF87562.1 - 2 7.9 15.0 2.9 7.4 8.6 2.0 1 1 1 2 2 2 0 IncA protein Ax_dynein_light PF10211.4 CDF87562.1 - 2.2 8.0 13.9 1 9.1 5.6 2.1 1 1 1 2 2 2 0 Axonemal dynein light chain DUF342 PF03961.8 CDF87562.1 - 2.3 6.5 7.3 4.8 5.4 4.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF342) SlyX PF04102.7 CDF87562.1 - 3 8.2 14.7 0.26 11.6 1.5 3.5 1 1 3 4 4 4 0 SlyX BLOC1_2 PF10046.4 CDF87562.1 - 3.5 7.8 11.3 1.6 8.9 1.2 2.8 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fib_alpha PF08702.5 CDF87562.1 - 3.6 7.7 12.3 7.7 6.6 4.4 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family AAA_23 PF13476.1 CDF87562.1 - 4.8 7.4 6.0 6.6 7.0 4.1 1.2 1 0 0 1 1 1 0 AAA domain APG6 PF04111.7 CDF87562.1 - 4.9 6.0 14.3 6.3 5.7 8.3 1.9 1 1 1 2 2 2 0 Autophagy protein Apg6 DUF2968 PF11180.3 CDF87562.1 - 5.5 6.3 15.5 0.25 10.6 6.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) FUSC PF04632.7 CDF87562.1 - 5.5 5.2 9.0 20 3.4 6.5 1.7 1 1 0 1 1 1 0 Fusaric acid resistance protein family DUF3347 PF11827.3 CDF87562.1 - 8.2 6.3 8.0 8.7 6.3 4.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3347) Atg14 PF10186.4 CDF87562.1 - 9 5.1 11.6 19 4.0 7.7 1.8 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DivIC PF04977.10 CDF87562.1 - 9.7 5.7 9.4 2.8 7.4 3.1 2.5 2 1 0 2 2 2 0 Septum formation initiator Ribosomal_L27e PF01777.13 CDF87563.1 - 4.1e-37 126.1 4.1 5.5e-37 125.7 2.9 1.2 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.24 CDF87563.1 - 0.00029 20.4 1.6 0.0006 19.4 1.1 1.6 1 0 0 1 1 1 1 KOW motif Ndr PF03096.9 CDF87563.1 - 0.13 10.7 0.0 0.22 9.9 0.0 1.4 1 0 0 1 1 1 0 Ndr family tRNA-synt_2b PF00587.20 CDF87564.1 - 8.6e-22 77.5 0.0 1.4e-21 76.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 CDF87564.1 - 0.00054 19.9 2.4 0.0011 19.0 1.7 1.5 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain DUF4200 PF13863.1 CDF87564.1 - 0.036 14.0 2.4 0.081 12.8 1.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) IncA PF04156.9 CDF87564.1 - 0.071 12.6 4.8 0.12 11.9 3.4 1.3 1 0 0 1 1 1 0 IncA protein Bacillus_HBL PF05791.6 CDF87564.1 - 0.079 12.3 0.7 0.14 11.4 0.2 1.6 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) OmpH PF03938.9 CDF87564.1 - 0.14 12.1 1.0 0.22 11.4 0.7 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Metallophos_2 PF12850.2 CDF87565.1 - 3.4e-16 59.4 0.0 5.3e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Acetyltransf_1 PF00583.19 CDF87566.1 - 3.9e-16 58.8 0.0 6.3e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 CDF87566.1 - 0.00011 21.8 0.0 0.00018 21.2 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.1 CDF87566.1 - 0.00018 21.5 0.0 0.00033 20.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 CDF87566.1 - 0.0025 17.9 0.0 0.0041 17.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 CDF87566.1 - 0.0071 16.2 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF3749 PF12568.3 CDF87566.1 - 0.033 13.7 0.1 0.055 13.0 0.1 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 CDF87566.1 - 0.09 12.6 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase TRAPP PF04051.11 CDF87567.1 - 4.9e-46 156.0 0.0 6.5e-46 155.6 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DDHD PF02862.12 CDF87570.1 - 4.8e-45 154.1 0.1 3.1e-28 99.1 0.0 2.5 2 1 1 3 3 3 2 DDHD domain DUF2305 PF10230.4 CDF87570.1 - 0.011 15.1 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) LCAT PF02450.10 CDF87570.1 - 0.019 13.9 0.1 0.058 12.3 0.0 1.8 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase DUF676 PF05057.9 CDF87570.1 - 0.021 14.0 0.0 1.2 8.4 0.0 2.3 2 0 0 2 2 2 0 Putative serine esterase (DUF676) Abhydrolase_5 PF12695.2 CDF87570.1 - 0.04 13.6 0.0 0.64 9.7 0.0 2.5 3 0 0 3 3 3 0 Alpha/beta hydrolase family DUF21 PF01595.15 CDF87571.1 - 1.5e-29 102.5 0.3 2.7e-29 101.7 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF21 CBS PF00571.23 CDF87571.1 - 0.044 13.5 0.0 1.3 8.8 0.0 2.7 2 0 0 2 2 2 0 CBS domain T4_Gp59_C PF08994.5 CDF87571.1 - 0.077 13.1 0.0 0.21 11.7 0.0 1.7 1 0 0 1 1 1 0 T4 gene Gp59 loader of gp41 DNA helicase C-term Pribosyl_synth PF14572.1 CDF87572.1 - 4.1e-45 153.7 0.5 6.3e-45 153.1 0.3 1.3 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.1 CDF87572.1 - 4.4e-35 119.9 0.1 4.4e-34 116.6 0.0 2.4 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.22 CDF87572.1 - 9.1e-14 51.2 0.0 2.6e-13 49.7 0.0 1.8 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 CDF87572.1 - 0.037 13.2 0.1 0.064 12.4 0.1 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Adap_comp_sub PF00928.16 CDF87573.1 - 5.8e-77 258.3 0.1 7.4e-77 257.9 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Sec16 PF12932.2 CDF87573.1 - 0.11 12.4 0.1 0.71 9.8 0.0 2.3 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region DUF1324 PF07038.6 CDF87574.1 - 0.015 15.2 0.0 0.036 14.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1324) CRT10 PF08728.5 CDF87575.1 - 2.8e-150 501.6 0.1 5.6e-150 500.6 0.1 1.5 1 1 0 1 1 1 1 CRT10 Pkinase PF00069.20 CDF87576.1 - 1.2e-49 168.8 0.1 3.8e-49 167.1 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF87576.1 - 7e-21 74.4 0.0 1.4e-20 73.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF87576.1 - 0.00011 21.3 0.0 0.00034 19.6 0.0 1.8 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.17 CDF87576.1 - 0.028 13.7 0.1 0.091 12.0 0.1 2.0 1 0 0 1 1 1 0 RIO1 family APH PF01636.18 CDF87576.1 - 0.18 11.4 0.0 3 7.5 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Actin PF00022.14 CDF87577.1 - 3.5e-114 381.3 0.0 4.1e-114 381.0 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.8 CDF87577.1 - 0.0072 14.9 0.0 0.046 12.3 0.0 2.1 1 1 0 1 1 1 1 MreB/Mbl protein DUF3449 PF11931.3 CDF87578.1 - 1.7e-63 213.7 0.6 1.7e-63 213.7 0.4 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF3449) zf-C2H2_jaz PF12171.3 CDF87578.1 - 6.1e-06 26.2 5.4 2.8e-05 24.1 0.6 2.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CDF87578.1 - 4.6e-05 23.4 4.2 0.019 15.1 0.7 2.7 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 CDF87578.1 - 0.00015 21.8 3.3 0.0063 16.6 0.8 3.0 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.1 CDF87578.1 - 0.16 12.3 6.7 0.94 9.9 1.2 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.21 CDF87578.1 - 0.32 11.4 8.9 0.46 10.9 0.4 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type Spore_III_AB PF09548.5 CDF87578.1 - 1.3 8.7 8.6 6.7 6.4 0.1 2.3 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) tRNA_Me_trans PF03054.11 CDF87580.1 - 2.3e-114 381.7 0.0 2.6e-114 381.5 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase Asn_synthase PF00733.16 CDF87580.1 - 0.0018 17.8 0.0 0.003 17.1 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase NAD_synthase PF02540.12 CDF87580.1 - 0.016 14.1 0.0 0.26 10.1 0.0 2.2 2 0 0 2 2 2 0 NAD synthase Inositol_P PF00459.20 CDF87581.1 - 7.3e-58 196.0 0.3 2.6e-57 194.2 0.2 1.7 1 1 0 1 1 1 1 Inositol monophosphatase family Git3 PF11710.3 CDF87582.1 - 7.4e-76 254.2 12.1 1.5e-75 253.2 8.4 1.5 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Git3_C PF11970.3 CDF87582.1 - 1.4e-32 111.2 5.3 1.4e-32 111.2 3.7 2.1 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term RseC_MucC PF04246.7 CDF87582.1 - 0.018 14.5 0.0 0.058 12.9 0.0 1.8 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Exo_endo_phos PF03372.18 CDF87583.1 - 4.3e-16 59.6 0.0 5.1e-16 59.3 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PseudoU_synth_2 PF00849.17 CDF87584.1 - 2.1e-33 115.4 0.0 3.9e-33 114.5 0.0 1.5 1 0 0 1 1 1 1 RNA pseudouridylate synthase dCMP_cyt_deam_1 PF00383.17 CDF87584.1 - 1.8e-19 69.2 0.0 3.9e-19 68.1 0.0 1.6 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region PQQ PF01011.16 CDF87584.1 - 0.013 15.0 0.1 0.036 13.6 0.0 1.8 1 0 0 1 1 1 0 PQQ enzyme repeat NARP1 PF12569.3 CDF87585.1 - 9.2e-114 381.0 19.5 8.6e-81 272.2 2.3 4.4 4 1 0 4 4 4 2 NMDA receptor-regulated protein 1 TPR_2 PF07719.12 CDF87585.1 - 2.9e-15 54.8 6.3 0.0063 16.3 0.5 7.3 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_11 PF13414.1 CDF87585.1 - 4.4e-15 55.0 11.1 0.001 18.6 0.2 4.8 5 0 0 5 5 5 4 TPR repeat TPR_16 PF13432.1 CDF87585.1 - 2e-14 53.7 3.9 0.0029 18.2 0.0 5.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.1 CDF87585.1 - 9.2e-13 47.6 0.7 0.0061 17.0 0.1 7.4 6 3 3 9 9 8 1 Tetratricopeptide repeat TPR_19 PF14559.1 CDF87585.1 - 1.6e-12 47.5 13.1 0.046 14.0 0.8 5.7 4 2 1 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.1 CDF87585.1 - 1.5e-11 44.0 6.0 0.023 14.6 0.0 5.4 4 1 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.23 CDF87585.1 - 4.7e-07 29.1 11.8 0.0026 17.2 0.5 6.4 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_17 PF13431.1 CDF87585.1 - 2.4e-06 27.3 8.8 1.8 8.9 0.0 6.6 6 0 0 6 6 6 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 CDF87585.1 - 0.00017 21.4 8.5 0.17 11.7 0.1 4.4 4 0 0 4 4 4 2 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.1 CDF87585.1 - 0.00092 18.8 17.1 1.1 9.1 0.3 7.5 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_6 PF13174.1 CDF87585.1 - 0.05 14.0 10.6 0.064 13.7 0.1 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.1 CDF87585.1 - 0.61 10.1 2.7 10 6.2 0.0 4.4 6 0 0 6 6 6 0 Tetratricopeptide repeat HLH PF00010.21 CDF87586.1 - 5.5e-16 58.0 0.0 9.1e-16 57.2 0.0 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain SIR2 PF02146.12 CDF87587.1 - 5.3e-66 221.7 0.0 1e-65 220.8 0.0 1.5 2 0 0 2 2 2 1 Sir2 family DUF592 PF04574.8 CDF87587.1 - 5.1e-63 211.2 0.2 8.1e-63 210.5 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.17 CDF87587.1 - 0.00013 21.7 0.0 0.059 13.1 0.0 2.3 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain DUF164 PF02591.10 CDF87587.1 - 0.19 11.5 0.5 0.65 9.8 0.4 1.9 1 0 0 1 1 1 0 Putative zinc ribbon domain zf-met PF12874.2 CDF87588.1 - 2.5e-05 24.3 1.2 5.4e-05 23.2 0.8 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 CDF87588.1 - 0.075 13.1 0.1 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Nuf2 PF03800.9 CDF87589.1 - 6.5e-47 159.1 0.5 6.5e-47 159.1 0.3 2.3 3 0 0 3 3 3 1 Nuf2 family Reo_sigmaC PF04582.7 CDF87589.1 - 1.4 8.0 10.5 0.76 8.8 2.9 2.5 1 1 1 2 2 2 0 Reovirus sigma C capsid protein HycH PF07450.6 CDF87589.1 - 2.1 8.4 9.3 0.31 11.1 0.4 2.7 3 0 0 3 3 3 0 Formate hydrogenlyase maturation protein HycH FlaC_arch PF05377.6 CDF87589.1 - 3.2 7.6 25.6 2.3 8.1 0.5 4.9 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) IFT46_B_C PF12317.3 CDF87589.1 - 7.7 5.8 14.1 4.9 6.4 0.1 3.2 2 1 0 3 3 3 0 Intraflagellar transport complex B protein 46 C terminal CENP-F_leu_zip PF10473.4 CDF87589.1 - 8.1 6.2 45.4 0.91 9.3 7.8 3.5 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FMO-like PF00743.14 CDF87590.1 - 6.3e-13 47.7 1.8 0.00013 20.3 0.1 3.3 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 CDF87590.1 - 5e-07 29.9 0.0 0.014 15.4 0.0 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CDF87590.1 - 0.00014 21.7 0.0 0.27 11.0 0.0 3.1 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CDF87590.1 - 0.00015 21.5 0.0 0.025 14.3 0.0 3.3 3 0 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 CDF87590.1 - 0.034 14.1 0.0 0.075 13.0 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 CDF87590.1 - 0.21 9.9 0.0 0.65 8.4 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein PAPS_reduct PF01507.14 CDF87593.1 - 1.1e-32 113.2 0.0 2.8e-32 111.9 0.0 1.6 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family CHCH PF06747.8 CDF87594.1 - 0.00011 22.0 0.3 0.00016 21.5 0.2 1.2 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.5 CDF87594.1 - 0.017 14.8 0.5 0.02 14.6 0.3 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like Sdh5 PF03937.11 CDF87595.1 - 6e-25 86.7 0.3 1.2e-24 85.7 0.2 1.5 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase E1_DerP2_DerF2 PF02221.10 CDF87596.1 - 8e-25 87.6 0.0 9.2e-25 87.4 0.0 1.1 1 0 0 1 1 1 1 ML domain TRP_N PF14558.1 CDF87596.1 - 0.014 15.4 0.0 0.017 15.1 0.0 1.2 1 0 0 1 1 1 0 ML-like domain Metallophos PF00149.23 CDF87597.1 - 4.4e-43 147.0 0.1 5.4e-43 146.7 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 CDF87597.1 - 0.00041 20.2 0.0 0.00091 19.0 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DIL PF01843.14 CDF87597.1 - 0.086 12.7 0.1 0.3 10.9 0.0 1.9 2 0 0 2 2 2 0 DIL domain PCI PF01399.22 CDF87598.1 - 3.4e-13 49.8 0.2 2.3e-12 47.1 0.0 2.3 2 0 0 2 2 2 1 PCI domain Smg4_UPF3 PF03467.10 CDF87599.1 - 3.5e-26 92.2 0.2 3.5e-26 92.2 0.1 2.0 1 1 2 3 3 3 1 Smg-4/UPF3 family DUF1965 PF09248.5 CDF87599.1 - 0.078 12.8 0.6 0.36 10.7 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1965) Mpv17_PMP22 PF04117.7 CDF87600.1 - 0.00013 21.4 0.7 0.00033 20.2 0.5 1.6 1 0 0 1 1 1 1 Mpv17 / PMP22 family LSM PF01423.17 CDF87601.1 - 1.9e-18 65.7 0.0 3.2e-18 65.0 0.0 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 CDF87601.1 - 0.00076 19.3 0.0 0.0011 18.8 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain PRP38 PF03371.10 CDF87602.1 - 7.7e-44 149.3 0.9 1e-43 148.9 0.6 1.0 1 0 0 1 1 1 1 PRP38 family DUF4219 PF13961.1 CDF87602.1 - 0.4 10.1 3.1 2 7.9 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4219) Prefoldin PF02996.12 CDF87606.1 - 2e-30 104.9 0.1 2.6e-30 104.5 0.1 1.2 1 0 0 1 1 1 1 Prefoldin subunit DUF336 PF03928.9 CDF87607.1 - 3.9e-21 75.2 0.0 4.8e-21 74.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF336) RHINO PF15319.1 CDF87608.1 - 0.51 10.1 6.9 0.039 13.7 0.6 2.2 3 0 0 3 3 3 0 RAD9, RAD1, HUS1-interacting nuclear orphan protein NatB_MDM20 PF09797.4 CDF87609.1 - 3.6e-57 193.7 16.1 4.5e-57 193.4 7.5 3.1 3 1 0 3 3 3 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_11 PF13414.1 CDF87609.1 - 0.0087 15.6 0.0 0.028 14.0 0.0 1.8 1 0 0 1 1 1 1 TPR repeat TPR_1 PF00515.23 CDF87609.1 - 0.011 15.3 0.1 0.067 12.8 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.12 CDF87609.1 - 0.025 14.4 0.0 0.17 11.9 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 CDF87609.1 - 0.037 13.8 0.0 3 7.8 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Brix PF04427.13 CDF87610.1 - 3.6e-41 140.9 0.1 4.5e-41 140.6 0.1 1.1 1 0 0 1 1 1 1 Brix domain DUF468 PF04318.7 CDF87610.1 - 0.055 14.0 0.1 0.24 11.9 0.0 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF468) DUF2611 PF11022.3 CDF87611.1 - 6.2e-23 80.6 0.0 6.7e-23 80.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2611) Peptidase_S10 PF00450.17 CDF87612.1 - 2.9e-126 421.9 0.1 3.5e-126 421.7 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.2 CDF87612.1 - 0.0013 18.6 0.0 0.0035 17.2 0.0 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family SIN1 PF05422.7 CDF87613.1 - 2.5e-31 108.8 4.4 2.5e-31 108.8 3.0 3.6 3 1 0 3 3 3 1 Stress-activated map kinase interacting protein 1 (SIN1) TUG-UBL1 PF11470.3 CDF87613.1 - 0.0017 18.2 0.4 0.013 15.3 0.2 2.3 2 0 0 2 2 2 1 GLUT4 regulating protein TUG RBD PF02196.10 CDF87613.1 - 0.021 14.5 0.0 0.054 13.2 0.0 1.6 1 0 0 1 1 1 0 Raf-like Ras-binding domain CaM_bdg_C0 PF10562.4 CDF87613.1 - 2.8 7.8 6.7 3 7.7 0.3 2.6 2 0 0 2 2 2 0 Calmodulin-binding domain C0 of NMDA receptor NR1 subunit RNase_T PF00929.19 CDF87614.1 - 7.7e-24 84.8 0.0 6.9e-23 81.7 0.0 2.0 2 0 0 2 2 2 1 Exonuclease DNA_pol_A_exo1 PF01612.15 CDF87614.1 - 0.029 13.8 0.0 0.092 12.2 0.0 1.8 1 1 0 1 1 1 0 3'-5' exonuclease RasGAP PF00616.14 CDF87615.1 - 5e-37 127.4 6.0 1e-36 126.4 0.4 3.6 3 0 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase DUF3321 PF11968.3 CDF87616.1 - 8.1e-82 274.1 0.1 1e-81 273.7 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase (DUF3321) Methyltransf_23 PF13489.1 CDF87616.1 - 9.8e-05 22.1 0.0 0.00015 21.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain DEAD PF00270.24 CDF87617.1 - 6.1e-38 129.9 0.8 1.6e-37 128.6 0.0 2.1 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF87617.1 - 8.4e-23 80.0 0.1 2.6e-22 78.4 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain eRF1_2 PF03464.10 CDF87618.1 - 8.7e-46 155.5 0.1 1.5e-45 154.8 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.10 CDF87618.1 - 2e-40 137.6 0.5 4.1e-40 136.5 0.3 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.10 CDF87618.1 - 2.3e-28 98.4 0.0 3.8e-28 97.6 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 ZZ PF00569.12 CDF87619.1 - 8.4e-06 25.2 7.7 8.4e-06 25.2 5.3 2.4 2 1 1 3 3 3 2 Zinc finger, ZZ type ATG19_autophagy PF12744.2 CDF87619.1 - 0.0049 16.1 0.0 0.013 14.7 0.0 1.9 1 1 0 1 1 1 1 Autophagy protein Atg19, Atg8-binding ADH_N PF08240.7 CDF87621.1 - 2.9e-30 104.2 1.2 1.5e-29 101.9 0.2 2.2 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CDF87621.1 - 9.2e-29 99.6 1.8 1.4e-28 98.9 1.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CDF87621.1 - 8.5e-05 23.4 0.5 0.00016 22.5 0.1 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Ribosomal_S9 PF00380.14 CDF87622.1 - 5.2e-40 136.4 0.0 1.1e-39 135.4 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S9/S16 CENP-S PF15630.1 CDF87623.1 - 2.2e-25 88.5 0.0 2.7e-25 88.3 0.0 1.1 1 0 0 1 1 1 1 Kinetochore component CENP-S CENP-T PF15511.1 CDF87623.1 - 4.5e-05 22.8 0.0 5.9e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T Histone PF00125.19 CDF87623.1 - 0.013 15.6 0.0 0.022 14.8 0.0 1.4 1 1 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.8 CDF87623.1 - 0.044 13.5 0.1 0.061 13.0 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated IRS PF02174.12 CDF87623.1 - 0.06 12.9 0.0 0.08 12.5 0.0 1.3 1 1 0 1 1 1 0 PTB domain (IRS-1 type) PCP_red PF08369.5 CDF87623.1 - 0.073 12.9 0.1 0.16 11.8 0.0 1.6 2 0 0 2 2 2 0 Proto-chlorophyllide reductase 57 kD subunit TFIID-31kDa PF02291.10 CDF87623.1 - 0.11 12.2 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit DUF3337 PF11816.3 CDF87624.1 - 1.1e-60 205.7 7.1 1.1e-60 205.7 4.9 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF3337) WD40 PF00400.27 CDF87624.1 - 4.1e-10 39.1 6.2 0.00088 19.0 0.0 5.5 5 0 0 5 5 5 3 WD domain, G-beta repeat RNA_pol_Rpb5_C PF01191.14 CDF87625.1 - 7.3e-33 111.9 0.3 1.2e-32 111.2 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.9 CDF87625.1 - 4.3e-32 110.3 0.7 7.3e-32 109.6 0.2 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.7 CDF87625.1 - 0.088 12.6 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Restriction endonuclease RibD_C PF01872.12 CDF87626.1 - 4e-36 124.5 0.0 4.5e-36 124.3 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain Prp19_bind PF06991.6 CDF87627.1 - 3.9e-05 23.0 19.3 5e-05 22.7 13.4 1.1 1 0 0 1 1 1 1 Splicing factor, Prp19-binding domain CAF-1_p150 PF11600.3 CDF87627.1 - 0.34 10.2 23.6 0.44 9.8 16.3 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Pyrid_oxidase_2 PF13883.1 CDF87628.1 - 1.4e-34 119.2 0.0 1.7e-34 119.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Thioredoxin PF00085.15 CDF87629.1 - 5.6e-09 35.6 0.0 1.3e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 CDF87629.1 - 0.014 15.5 0.2 0.076 13.1 0.0 2.3 3 0 0 3 3 3 0 Thioredoxin-like Aldo_ket_red PF00248.16 CDF87631.1 - 2e-37 128.5 0.0 2.5e-37 128.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family GntR PF00392.16 CDF87631.1 - 0.0031 16.9 0.0 0.26 10.7 0.0 2.7 2 0 0 2 2 2 2 Bacterial regulatory proteins, gntR family MutS_V PF00488.16 CDF87632.1 - 5.7e-97 323.7 0.1 9.5e-97 323.0 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 CDF87632.1 - 1.1e-31 110.2 2.7 1.1e-31 110.2 1.9 2.1 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.12 CDF87632.1 - 6.4e-21 74.8 1.5 1e-20 74.2 0.0 2.2 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.13 CDF87632.1 - 2.5e-17 62.8 1.1 2.5e-17 62.8 0.8 2.4 2 0 0 2 2 2 1 MutS family domain IV MutS_I PF01624.15 CDF87632.1 - 2.8e-09 36.9 0.0 2.1e-08 34.1 0.0 2.2 2 0 0 2 2 2 1 MutS domain I RsbRD_N PF14361.1 CDF87632.1 - 0.044 14.2 0.2 0.14 12.6 0.2 1.8 1 0 0 1 1 1 0 RsbT co-antagonist protein rsbRD N-terminal domain WEMBL PF05701.6 CDF87633.1 - 1.9e-06 26.6 36.7 1.9e-06 26.6 25.4 2.4 3 0 0 3 3 3 1 Weak chloroplast movement under blue light HALZ PF02183.13 CDF87633.1 - 3.9e-05 23.2 30.0 0.00082 19.0 1.0 7.0 4 1 1 6 6 6 3 Homeobox associated leucine zipper ADIP PF11559.3 CDF87633.1 - 0.0001 22.2 13.9 0.0001 22.2 9.6 6.4 4 2 3 7 7 6 2 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.4 CDF87633.1 - 0.00056 19.7 68.3 0.0017 18.2 7.5 6.6 3 1 2 6 6 6 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIVA PF05103.8 CDF87633.1 - 0.0056 16.7 1.4 0.0056 16.7 1.0 6.0 3 1 3 6 6 6 2 DivIVA protein MbeD_MobD PF04899.7 CDF87633.1 - 0.13 12.1 12.6 7.7 6.4 0.4 4.8 4 0 0 4 4 4 0 MbeD/MobD like Myb_DNA-bind_3 PF12776.2 CDF87633.1 - 1.8 9.2 9.6 4.7 7.9 1.0 3.7 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain Reo_sigmaC PF04582.7 CDF87633.1 - 6.8 5.7 21.6 5.3 6.1 2.8 4.0 2 1 2 4 4 4 0 Reovirus sigma C capsid protein PQ-loop PF04193.9 CDF87634.1 - 1.8e-42 142.6 11.9 1.7e-22 78.7 0.5 3.1 3 0 0 3 3 3 2 PQ loop repeat tRNA_m1G_MT PF01746.16 CDF87635.1 - 1.3e-36 125.9 0.2 2.2e-36 125.2 0.1 1.4 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase TTL PF03133.10 CDF87635.1 - 0.0068 15.3 0.1 0.0068 15.3 0.1 1.6 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family Vps52 PF04129.7 CDF87636.1 - 1.5e-132 442.7 27.2 2.8e-132 441.8 18.8 1.4 1 1 0 1 1 1 1 Vps52 / Sac2 family Sec8_exocyst PF04048.9 CDF87636.1 - 0.022 14.3 3.3 0.04 13.5 0.9 2.4 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain YL1 PF05764.8 CDF87637.1 - 5e-55 186.7 49.0 5e-55 186.7 34.0 3.0 2 1 1 3 3 3 1 YL1 nuclear protein YL1_C PF08265.6 CDF87637.1 - 3.8e-11 42.3 0.5 7.7e-11 41.3 0.3 1.5 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Methyltransf_23 PF13489.1 CDF87638.1 - 1.1e-21 77.2 0.0 2e-21 76.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDF87638.1 - 5.8e-17 61.6 0.0 8.2e-17 61.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDF87638.1 - 6.2e-17 61.8 0.0 1.1e-16 61.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDF87638.1 - 7.2e-15 55.2 0.0 1.4e-14 54.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDF87638.1 - 1.7e-13 51.0 0.0 3e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDF87638.1 - 8.4e-10 38.9 0.0 1.4e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 CDF87638.1 - 5.4e-07 29.0 0.0 8.2e-07 28.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.15 CDF87638.1 - 2.7e-06 26.6 0.0 3.6e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.9 CDF87638.1 - 1e-05 24.9 0.0 1.8e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 CDF87638.1 - 1e-05 25.5 0.0 3.5e-05 23.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain NodS PF05401.6 CDF87638.1 - 0.00016 21.1 0.0 0.00073 18.9 0.0 1.8 2 0 0 2 2 2 1 Nodulation protein S (NodS) Ubie_methyltran PF01209.13 CDF87638.1 - 0.00025 20.2 0.0 0.00035 19.7 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.14 CDF87638.1 - 0.00033 20.2 0.0 0.00066 19.2 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.12 CDF87638.1 - 0.0015 17.6 0.0 0.48 9.4 0.0 2.2 2 0 0 2 2 2 2 Putative methyltransferase Methyltransf_32 PF13679.1 CDF87638.1 - 0.0019 17.9 0.0 0.0031 17.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Pox_LP_H2 PF03356.10 CDF87638.1 - 0.0042 16.7 0.0 0.0072 16.0 0.0 1.4 1 0 0 1 1 1 1 Viral late protein H2 MetW PF07021.7 CDF87638.1 - 0.0049 16.2 0.0 0.012 15.0 0.0 1.5 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW DREV PF05219.7 CDF87638.1 - 0.0084 15.0 0.0 0.018 13.9 0.0 1.4 1 1 0 1 1 1 1 DREV methyltransferase tRNA-synt_1b PF00579.20 CDF87639.1 - 2e-18 66.5 0.0 4e-13 49.1 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (W and Y) AAA_18 PF13238.1 CDF87639.1 - 0.13 12.5 0.0 16 5.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain DHBP_synthase PF00926.14 CDF87640.1 - 3.8e-77 257.8 0.0 4.3e-77 257.7 0.0 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase WD40 PF00400.27 CDF87641.1 - 0.001 18.8 0.8 0.04 13.8 0.1 3.3 4 0 0 4 4 4 1 WD domain, G-beta repeat Sld5 PF05916.6 CDF87642.1 - 1.7e-18 66.9 0.6 3e-18 66.1 0.4 1.4 1 0 0 1 1 1 1 GINS complex protein Peptidase_M16_C PF05193.16 CDF87643.1 - 9.6e-17 61.2 0.0 1.4e-12 47.7 0.0 2.6 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 CDF87643.1 - 5.7e-09 35.8 0.0 3.2e-07 30.2 0.0 2.7 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Pkinase PF00069.20 CDF87644.1 - 4.4e-63 212.8 0.0 6.8e-63 212.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF87644.1 - 1.8e-33 115.7 0.0 2.7e-33 115.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF87644.1 - 7.6e-08 31.6 0.0 1.2e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 CDF87644.1 - 0.018 14.0 0.0 0.034 13.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 CDF87644.1 - 0.063 12.6 0.7 0.57 9.5 0.0 2.2 2 0 0 2 2 2 0 RIO1 family APH PF01636.18 CDF87644.1 - 0.14 11.8 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family HlyIII PF03006.15 CDF87646.1 - 3.6e-47 160.6 22.2 4.2e-47 160.4 15.4 1.0 1 0 0 1 1 1 1 Haemolysin-III related PTS_2-RNA PF01885.11 CDF87648.1 - 1.9e-54 183.8 0.1 2.4e-54 183.4 0.1 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family La PF05383.12 CDF87648.1 - 0.085 12.6 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 La domain CPL PF08144.6 CDF87651.1 - 7.7e-21 74.4 0.1 1.6e-19 70.2 0.0 2.8 2 0 0 2 2 2 1 CPL (NUC119) domain PUF PF00806.14 CDF87651.1 - 0.003 16.9 0.9 6.7 6.4 0.0 5.3 7 0 0 7 7 7 1 Pumilio-family RNA binding repeat DUF3366 PF11846.3 CDF87651.1 - 0.16 11.7 0.2 0.39 10.5 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3366) Sugar_tr PF00083.19 CDF87652.1 - 5.9e-137 456.9 31.4 7.3e-137 456.6 21.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CDF87652.1 - 2.9e-30 105.1 42.1 3.3e-27 95.1 21.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 CDF87652.1 - 1.8e-08 33.0 0.6 1.8e-08 33.0 0.4 2.4 2 1 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Sec20 PF03908.8 CDF87653.1 - 6.1e-29 99.5 0.8 6.1e-29 99.5 0.5 2.0 2 0 0 2 2 2 1 Sec20 V-SNARE_C PF12352.3 CDF87653.1 - 0.18 11.9 0.3 0.18 11.9 0.2 2.0 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus ATG16 PF08614.6 CDF87653.1 - 1.3 8.8 8.8 2.9 7.6 5.8 1.9 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) ERG4_ERG24 PF01222.12 CDF87655.1 - 1.3e-164 547.8 6.9 1.4e-164 547.7 4.8 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.7 CDF87655.1 - 7.2e-07 28.7 0.4 1.3e-06 27.8 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Aha1_N PF09229.6 CDF87656.1 - 1.7e-28 99.1 0.0 2.2e-28 98.8 0.0 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal RNase_P_pop3 PF08228.6 CDF87657.1 - 4.4e-36 124.0 0.7 5.7e-36 123.7 0.5 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 WSC PF01822.14 CDF87658.1 - 4.9e-11 42.3 8.6 4.9e-11 42.3 6.0 3.9 2 1 1 3 3 3 1 WSC domain Adeno_E3_CR2 PF02439.10 CDF87658.1 - 0.002 17.6 1.9 0.0045 16.4 1.3 1.5 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 EphA2_TM PF14575.1 CDF87658.1 - 0.014 15.8 0.0 0.04 14.3 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.15 CDF87658.1 - 0.73 9.5 4.5 1.7 8.3 3.1 1.5 1 0 0 1 1 1 0 Syndecan domain Ribosomal_L18e PF00828.14 CDF87659.1 - 1.8e-23 83.3 0.2 7.3e-23 81.3 0.1 1.9 2 0 0 2 2 2 1 Ribosomal protein L18e/L15 HLH PF00010.21 CDF87660.1 - 0.0072 16.0 0.1 0.0072 16.0 0.1 2.3 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain DUF4467 PF14729.1 CDF87660.1 - 0.031 14.5 4.3 0.047 14.0 3.0 1.4 1 1 0 1 1 1 0 Domain of unknown function with cystatin-like fold (DUF4467) DUF1366 PF07104.6 CDF87660.1 - 0.12 12.0 1.4 0.19 11.3 0.7 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1366) DUF2058 PF09831.4 CDF87660.1 - 0.21 11.4 6.4 11 5.9 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2058) RRM_5 PF13893.1 CDF87661.1 - 8.3e-16 57.5 2.6 2.7e-08 33.5 0.2 2.5 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CDF87661.1 - 2.3e-15 55.9 1.0 2.1e-08 33.6 0.0 3.3 2 2 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF87661.1 - 9.3e-12 44.7 0.2 1.3e-06 28.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.8 CDF87661.1 - 0.055 13.2 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF972 PF06156.8 CDF87661.1 - 3 8.2 13.8 4.5 7.6 0.2 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF972) Adaptin_N PF01602.15 CDF87662.1 - 4.5e-113 378.3 12.0 5.6e-113 378.0 8.3 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.5 CDF87662.1 - 1.4e-45 154.8 1.3 1.4e-45 154.8 0.9 2.1 2 0 0 2 2 2 1 Coatomer gamma subunit appendage platform subdomain HEAT_2 PF13646.1 CDF87662.1 - 1.1e-09 38.3 4.6 0.0022 18.2 0.1 5.1 3 3 1 4 4 4 3 HEAT repeats HEAT PF02985.17 CDF87662.1 - 0.00052 19.8 7.3 29 5.0 0.0 6.8 7 0 0 7 7 7 0 HEAT repeat DUF3355 PF11835.3 CDF87662.1 - 0.035 13.9 0.9 0.12 12.2 0.7 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3355) HEAT_EZ PF13513.1 CDF87662.1 - 0.11 12.9 0.7 1.1 9.8 0.2 3.0 2 0 0 2 2 2 0 HEAT-like repeat Rcd1 PF04078.8 CDF87663.1 - 4.9e-121 402.5 3.2 4.9e-121 402.5 2.2 1.4 2 0 0 2 2 2 1 Cell differentiation family, Rcd1-like Lipase_chap PF03280.9 CDF87663.1 - 0.0011 18.5 27.9 0.0019 17.7 19.3 1.3 1 0 0 1 1 1 1 Proteobacterial lipase chaperone protein Pex14_N PF04695.8 CDF87663.1 - 0.0047 16.9 7.3 0.0075 16.3 5.0 1.3 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.8 CDF87663.1 - 0.012 15.5 14.8 0.015 15.1 10.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SRX PF09201.5 CDF87663.1 - 0.015 14.9 0.0 3.2 7.3 0.1 2.4 2 0 0 2 2 2 0 SRX Band_3_cyto PF07565.8 CDF87663.1 - 0.016 14.7 2.7 0.048 13.1 1.1 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF2249 PF10006.4 CDF87663.1 - 0.028 13.9 5.4 1.2 8.7 1.1 3.1 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2249) DUF1800 PF08811.6 CDF87663.1 - 0.045 12.6 7.7 0.069 12.0 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1800) OATP PF03137.15 CDF87663.1 - 0.059 11.4 0.3 0.081 10.9 0.2 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Suf PF05843.9 CDF87663.1 - 0.2 11.3 13.0 0.29 10.8 9.0 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4175 PF13779.1 CDF87663.1 - 0.2 9.2 26.8 0.27 8.9 18.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Sec62 PF03839.11 CDF87663.1 - 0.72 9.2 9.4 36 3.6 7.0 2.1 2 0 0 2 2 2 0 Translocation protein Sec62 FimP PF09766.4 CDF87663.1 - 1.5 7.7 19.3 2.4 7.1 13.4 1.2 1 0 0 1 1 1 0 Fms-interacting protein DUF912 PF06024.7 CDF87663.1 - 1.6 8.8 5.6 5.3 7.1 3.5 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) Med15 PF09606.5 CDF87663.1 - 2.4 6.2 43.1 3.2 5.8 29.9 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PAT1 PF09770.4 CDF87663.1 - 2.9 6.0 37.5 3.5 5.7 26.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Gag_spuma PF03276.9 CDF87663.1 - 3.2 5.9 19.7 2.6 6.2 12.7 1.5 2 0 0 2 2 2 0 Spumavirus gag protein RED_N PF07808.8 CDF87663.1 - 3.4 6.8 15.4 5.1 6.2 10.7 1.2 1 0 0 1 1 1 0 RED-like protein N-terminal region Serinc PF03348.10 CDF87663.1 - 4.3 5.9 7.0 7.2 5.2 4.9 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF605 PF04652.11 CDF87663.1 - 4.8 6.4 18.5 6.2 6.1 12.8 1.1 1 0 0 1 1 1 0 Vta1 like Pex16 PF08610.5 CDF87663.1 - 6.1 5.7 9.4 10 5.0 6.5 1.3 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) Cyclin_N PF00134.18 CDF87664.1 - 9.4e-19 67.2 0.0 2.1e-18 66.1 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.6 CDF87664.1 - 2.1e-10 41.1 0.0 4.6e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Cyclin AAA PF00004.24 CDF87665.1 - 1.8e-17 63.7 0.0 4.4e-17 62.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 CDF87665.1 - 3.1e-17 62.6 0.0 4e-15 55.8 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.6 CDF87665.1 - 4.2e-15 55.5 0.0 1e-14 54.2 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain Rad17 PF03215.10 CDF87665.1 - 9e-08 31.2 0.0 2.4e-06 26.5 0.0 2.2 1 1 0 2 2 2 1 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 CDF87665.1 - 2.6e-07 30.8 1.0 0.016 15.3 0.1 2.8 2 1 1 3 3 3 2 AAA domain RuvB_N PF05496.7 CDF87665.1 - 3.5e-07 29.5 0.0 7.2e-07 28.4 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 CDF87665.1 - 2.2e-06 27.7 0.3 0.0001 22.3 0.0 2.7 1 1 1 2 2 2 1 AAA ATPase domain DNA_pol3_delta PF06144.8 CDF87665.1 - 6.7e-06 25.7 0.1 2.2e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA_14 PF13173.1 CDF87665.1 - 1.4e-05 25.0 0.0 2.8e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.8 CDF87665.1 - 0.00011 21.2 0.0 0.00016 20.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) DEAD PF00270.24 CDF87665.1 - 0.00024 20.6 0.0 0.017 14.5 0.0 2.4 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_19 PF13245.1 CDF87665.1 - 0.00044 19.9 0.0 0.001 18.7 0.0 1.7 1 1 0 1 1 1 1 Part of AAA domain AAA_11 PF13086.1 CDF87665.1 - 0.00047 19.8 0.0 0.0017 17.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 CDF87665.1 - 0.00056 19.3 0.0 0.0012 18.2 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_17 PF13207.1 CDF87665.1 - 0.00066 20.4 0.0 0.0028 18.4 0.0 1.9 1 1 0 2 2 2 1 AAA domain AAA_25 PF13481.1 CDF87665.1 - 0.0017 17.7 0.1 0.033 13.5 0.1 2.3 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.13 CDF87665.1 - 0.0022 17.5 0.0 0.01 15.3 0.0 1.9 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.9 CDF87665.1 - 0.0027 17.4 0.1 0.012 15.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.1 CDF87665.1 - 0.0027 17.3 0.0 0.028 14.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 CDF87665.1 - 0.0031 16.9 0.3 1.1 8.5 0.0 2.4 1 1 1 2 2 2 1 AAA-like domain AAA_18 PF13238.1 CDF87665.1 - 0.0038 17.5 0.0 0.0096 16.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 CDF87665.1 - 0.0053 16.4 0.1 0.012 15.2 0.0 1.6 2 0 0 2 2 1 1 Archaeal ATPase ResIII PF04851.10 CDF87665.1 - 0.0073 16.1 0.0 0.22 11.3 0.0 2.5 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.1 CDF87665.1 - 0.0088 15.6 0.0 0.16 11.5 0.0 2.3 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.8 CDF87665.1 - 0.0093 14.7 0.0 0.086 11.5 0.0 2.1 2 0 0 2 2 2 1 TIP49 C-terminus AAA_3 PF07726.6 CDF87665.1 - 0.01 15.4 0.0 0.022 14.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.11 CDF87665.1 - 0.01 15.0 0.0 2.2 7.4 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_33 PF13671.1 CDF87665.1 - 0.02 14.7 0.0 0.059 13.2 0.0 1.8 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 CDF87665.1 - 0.025 14.7 0.0 0.047 13.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase DUF2075 PF09848.4 CDF87665.1 - 0.032 13.2 0.0 0.12 11.2 0.0 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Mg_chelatase PF01078.16 CDF87665.1 - 0.037 13.1 0.0 0.18 10.9 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.1 CDF87665.1 - 0.064 13.2 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Mid1 PF12929.2 CDF87666.1 - 1.4e-133 445.7 13.3 2e-133 445.2 9.2 1.2 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.17 CDF87666.1 - 0.1 12.9 4.9 0.39 11.0 0.8 2.6 2 1 0 2 2 2 0 Fz domain TruB_N PF01509.13 CDF87667.1 - 2.4e-42 144.5 0.8 1.5e-38 132.2 0.0 3.2 3 0 0 3 3 3 2 TruB family pseudouridylate synthase (N terminal domain) U3_snoRNA_assoc PF08297.6 CDF87667.1 - 0.03 14.5 9.0 0.054 13.7 1.1 2.7 2 0 0 2 2 2 0 U3 snoRNA associated ubiquitin PF00240.18 CDF87669.1 - 1.2e-08 34.2 0.1 2.5e-08 33.2 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.1 CDF87669.1 - 7.1e-05 22.6 0.1 0.00013 21.7 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.3 CDF87669.1 - 0.17 11.6 0.3 0.29 10.8 0.0 1.6 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like RabGAP-TBC PF00566.13 CDF87670.1 - 1.6e-43 148.7 1.7 8.6e-43 146.2 1.2 2.0 1 1 0 1 1 1 1 Rab-GTPase-TBC domain PalH PF08733.5 CDF87671.1 - 1e-88 297.5 5.6 1.3e-88 297.2 3.9 1.1 1 0 0 1 1 1 1 PalH/RIM21 ATP_synt_I PF03899.10 CDF87671.1 - 0.021 14.9 0.5 0.021 14.9 0.3 2.4 2 1 0 2 2 2 0 ATP synthase I chain YhhN PF07947.9 CDF87671.1 - 0.42 9.9 8.4 1.9 7.8 0.1 2.9 1 1 1 2 2 2 0 YhhN-like protein Pet20 PF08692.5 CDF87672.1 - 8.1e-12 45.2 0.1 3.3e-11 43.2 0.1 2.1 1 1 0 1 1 1 1 Mitochondrial protein Pet20 Sec7_N PF12783.2 CDF87673.1 - 1.6e-36 125.2 5.4 1.6e-36 125.2 3.7 3.8 4 0 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal UPF0262 PF06793.7 CDF87673.1 - 0.029 14.1 0.1 0.091 12.4 0.1 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0262) Pkinase PF00069.20 CDF87674.1 - 2e-66 223.8 0.0 3.5e-66 223.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF87674.1 - 9.6e-51 172.3 0.4 1.8e-50 171.4 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase PBD PF00786.23 CDF87674.1 - 6.5e-22 77.7 0.3 2.9e-21 75.6 0.2 2.3 1 0 0 1 1 1 1 P21-Rho-binding domain PH PF00169.24 CDF87674.1 - 1.4e-11 44.5 0.1 3.4e-11 43.2 0.1 1.6 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.1 CDF87674.1 - 5.6e-06 25.5 0.0 1e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PH_11 PF15413.1 CDF87674.1 - 8.8e-05 22.7 0.1 0.015 15.5 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain APH PF01636.18 CDF87674.1 - 0.0076 16.0 0.2 0.061 13.0 0.0 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.9 CDF87674.1 - 0.15 11.1 0.0 0.26 10.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_60s PF00428.14 CDF87674.1 - 0.36 11.2 4.2 7.7 6.9 2.8 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein RF-1 PF00472.15 CDF87676.1 - 3.6e-14 52.5 0.3 5.9e-14 51.8 0.2 1.3 1 1 0 1 1 1 1 RF-1 domain NTP_transf_2 PF01909.18 CDF87677.1 - 1.9e-17 63.3 0.0 6.1e-17 61.7 0.0 1.9 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.14 CDF87677.1 - 1.6e-14 53.5 0.0 3.4e-14 52.5 0.0 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase RD3 PF14473.1 CDF87677.1 - 0.017 14.6 1.0 0.043 13.2 0.7 1.7 1 0 0 1 1 1 0 RD3 protein DNA_pol_B_palm PF14792.1 CDF87677.1 - 0.04 13.9 0.0 0.083 12.9 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase beta palm ADK PF00406.17 CDF87678.1 - 2.1e-60 202.9 0.0 2.5e-60 202.7 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 CDF87678.1 - 7.2e-16 57.5 0.4 2.4e-15 55.9 0.0 2.0 3 0 0 3 3 3 1 Adenylate kinase, active site lid AAA_33 PF13671.1 CDF87678.1 - 2.8e-06 27.2 0.0 4.1e-06 26.7 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CDF87678.1 - 2.1e-05 24.8 0.0 4.9e-05 23.6 0.0 1.5 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 CDF87678.1 - 0.00013 22.7 0.0 0.00023 21.9 0.0 1.6 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.12 CDF87678.1 - 0.0041 16.5 0.0 0.011 15.1 0.0 1.6 1 0 0 1 1 1 1 Thymidylate kinase Zeta_toxin PF06414.7 CDF87678.1 - 0.073 12.1 0.0 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin GCR1_C PF12550.3 CDF87679.1 - 7.6e-25 86.5 0.9 1.3e-24 85.8 0.6 1.4 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes TPP_enzyme_N PF02776.13 CDF87679.1 - 0.0006 19.3 0.7 0.00089 18.7 0.5 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Med15 PF09606.5 CDF87679.1 - 0.014 13.6 17.0 0.016 13.4 11.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal VIT1 PF01988.14 CDF87679.1 - 0.016 14.6 0.3 0.016 14.6 0.2 1.5 2 0 0 2 2 2 0 VIT family Spt20 PF12090.3 CDF87679.1 - 0.02 14.2 1.0 0.027 13.8 0.7 1.2 1 0 0 1 1 1 0 Spt20 family BAF1_ABF1 PF04684.8 CDF87679.1 - 0.047 12.5 8.3 0.066 12.0 5.7 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor RskA PF10099.4 CDF87679.1 - 0.26 11.0 9.2 0.018 14.7 3.2 1.5 2 0 0 2 2 2 0 Anti-sigma-K factor rskA TSA PF03249.8 CDF87679.1 - 1.4 7.3 9.2 2 6.8 6.4 1.2 1 0 0 1 1 1 0 Type specific antigen Tropomyosin PF00261.15 CDF87679.1 - 4.2 6.3 9.5 0.079 12.0 0.4 2.0 2 0 0 2 2 2 0 Tropomyosin Fungal_trans PF04082.13 CDF87680.1 - 2.1e-09 36.6 2.5 5.6e-09 35.2 0.4 2.4 1 1 2 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF87680.1 - 1.2e-07 31.4 10.7 2.8e-07 30.3 7.4 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NAD_binding_1 PF00175.16 CDF87681.1 - 3.7e-20 72.5 0.0 5.5e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 CDF87681.1 - 8e-19 67.6 0.0 1.3e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 CDF87681.1 - 4.3e-07 29.9 0.0 2.7e-05 24.1 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain DUP PF00674.13 CDF87684.1 - 4.5e-05 23.3 0.6 0.00015 21.7 0.0 2.0 2 0 0 2 2 2 1 DUP family Phage_gp49_66 PF13876.1 CDF87686.1 - 3.2 7.8 5.9 0.86 9.7 1.1 2.2 2 0 0 2 2 2 0 Phage protein (N4 Gp49/phage Sf6 gene 66) family TPR_11 PF13414.1 CDF87687.1 - 0.0051 16.4 0.1 0.015 14.9 0.1 1.8 1 0 0 1 1 1 1 TPR repeat TPR_6 PF13174.1 CDF87687.1 - 0.048 14.1 0.0 0.16 12.4 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.12 CDF87687.1 - 0.067 13.1 0.0 0.18 11.8 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.1 CDF87687.1 - 0.079 12.9 0.1 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Redoxin PF08534.5 CDF87688.1 - 1.1e-28 99.6 0.0 1.3e-28 99.4 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 CDF87688.1 - 2.4e-09 36.9 0.0 3e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family MFS_1 PF07690.11 CDF87689.1 - 3e-28 98.5 33.3 3e-28 98.5 23.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pentapeptide_4 PF13599.1 CDF87689.1 - 0.0018 18.0 1.6 0.0018 18.0 1.1 2.6 3 0 0 3 3 3 1 Pentapeptide repeats (9 copies) Sugar_tr PF00083.19 CDF87689.1 - 0.013 14.1 38.2 0.011 14.3 10.4 3.6 2 2 1 3 3 3 0 Sugar (and other) transporter Pentapeptide_3 PF13576.1 CDF87689.1 - 2 8.3 11.1 0.21 11.5 3.1 2.7 2 1 0 2 2 2 0 Pentapeptide repeats (9 copies) Ribosomal_L18e PF00828.14 CDF87690.1 - 1.4e-23 83.7 0.1 2e-23 83.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 Ribosomal_S19e PF01090.14 CDF87691.1 - 1.7e-55 186.3 0.2 1.8e-55 186.1 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Nramp PF01566.13 CDF87692.1 - 2.9e-88 296.0 13.0 2.9e-88 296.0 9.0 1.5 2 0 0 2 2 2 1 Natural resistance-associated macrophage protein RRM_1 PF00076.17 CDF87693.1 - 4.4e-37 125.5 1.2 8.1e-20 70.2 0.0 3.2 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF87693.1 - 1.2e-32 111.6 0.1 4e-16 58.7 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF87693.1 - 5.4e-13 48.5 0.0 7.4e-06 25.7 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.6 CDF87693.1 - 0.0076 15.7 0.2 4.4 6.8 0.0 2.7 2 0 0 2 2 2 2 Ribonuclease B OB domain Peptidase_S64 PF08192.6 CDF87693.1 - 1.7 6.8 16.3 2.6 6.2 11.3 1.2 1 0 0 1 1 1 0 Peptidase family S64 SOBP PF15279.1 CDF87693.1 - 2.2 8.5 19.8 2.3 8.4 0.6 2.2 2 0 0 2 2 2 0 Sine oculis-binding protein GEMIN8 PF15348.1 CDF87693.1 - 8.9 6.2 25.0 0.65 9.9 11.2 2.6 3 0 0 3 3 3 0 Gemini of Cajal bodies-associated protein 8 UCH PF00443.24 CDF87693.1 - 9.1 5.3 19.4 0.43 9.6 8.7 1.9 2 0 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase UPF0020 PF01170.13 CDF87694.1 - 6.5e-14 51.8 0.0 1.7e-13 50.5 0.0 1.6 2 0 0 2 2 2 1 Putative RNA methylase family UPF0020 Methyltransf_26 PF13659.1 CDF87694.1 - 5.2e-09 36.1 0.0 8.7e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MethyltransfD12 PF02086.10 CDF87694.1 - 0.005 16.3 0.5 2.2 7.6 0.1 2.5 1 1 1 2 2 2 2 D12 class N6 adenine-specific DNA methyltransferase Ras PF00071.17 CDF87695.1 - 2.8e-29 101.6 0.6 4.1e-25 88.0 0.1 2.2 2 0 0 2 2 2 2 Ras family Miro PF08477.8 CDF87695.1 - 9.8e-13 48.6 0.1 8.6e-11 42.3 0.0 2.4 1 1 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDF87695.1 - 1.8e-06 27.3 0.2 1.4e-05 24.4 0.1 2.0 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_5 PF07728.9 CDF87695.1 - 0.0087 15.7 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Gtr1_RagA PF04670.7 CDF87695.1 - 0.025 13.7 1.3 0.3 10.1 0.9 2.1 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 CDF87695.1 - 0.026 13.9 0.0 0.065 12.6 0.0 1.5 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA PF00004.24 CDF87695.1 - 0.11 12.7 0.0 0.18 12.0 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.16 CDF87695.1 - 0.15 11.2 0.0 0.26 10.4 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TRM13 PF05206.9 CDF87696.1 - 4.5e-79 265.3 1.5 6e-79 264.9 1.0 1.2 1 0 0 1 1 1 1 Methyltransferase TRM13 zf-TRM13_CCCH PF11722.3 CDF87696.1 - 3.2e-10 39.1 2.5 9.9e-10 37.6 1.7 1.8 1 0 0 1 1 1 1 CCCH zinc finger in TRM13 protein zf-U11-48K PF05253.7 CDF87696.1 - 2.9e-09 36.4 4.2 9.7e-09 34.7 2.9 2.0 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger Methyltransf_32 PF13679.1 CDF87696.1 - 0.00024 20.7 2.4 0.00042 20.0 0.4 2.2 2 1 0 2 2 2 1 Methyltransferase domain Ldh_1_N PF00056.18 CDF87697.1 - 4.9e-40 136.6 0.0 7.1e-40 136.0 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 CDF87697.1 - 1.5e-35 122.4 0.0 2.3e-35 121.9 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Bax1-I PF01027.15 CDF87698.1 - 1.2e-38 132.8 21.8 1.4e-38 132.5 15.1 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Spore_YhaL PF14147.1 CDF87698.1 - 0.13 11.7 0.3 10 5.6 0.0 2.9 2 0 0 2 2 2 0 Sporulation protein YhaL Ribosomal_L23eN PF03939.8 CDF87699.1 - 3.6e-21 74.9 10.1 3.6e-21 74.9 7.0 2.2 2 1 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.15 CDF87699.1 - 6.4e-20 70.9 1.7 6.4e-20 70.9 1.2 1.8 2 0 0 2 2 2 1 Ribosomal protein L23 Ribosomal_S11 PF00411.14 CDF87700.1 - 1.2e-06 28.6 0.0 2e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S11 Pkinase PF00069.20 CDF87701.1 - 8.5e-57 192.2 0.0 1e-56 191.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF87701.1 - 4.9e-29 101.1 0.0 6.5e-29 100.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF87701.1 - 3.1e-05 23.0 0.0 5.6e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CDF87701.1 - 0.0001 22.1 0.0 0.0011 18.7 0.0 2.3 3 0 0 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.9 CDF87701.1 - 0.006 15.6 0.0 0.01 14.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 CDF87701.1 - 0.037 13.6 0.0 0.057 12.9 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase UPF0220 PF05255.6 CDF87702.1 - 2.7e-65 218.6 1.6 3e-65 218.4 1.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) Kri1_C PF12936.2 CDF87703.1 - 2.7e-31 107.3 2.6 2.7e-31 107.3 1.8 4.3 4 1 1 5 5 5 1 KRI1-like family C-terminal Kri1 PF05178.7 CDF87703.1 - 3.1e-16 59.4 15.7 3.1e-16 59.4 10.9 5.1 4 3 0 4 4 4 1 KRI1-like family CorA PF01544.13 CDF87704.1 - 4.4e-42 144.1 1.4 2.1e-24 86.0 0.0 2.2 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein DUF2231 PF09990.4 CDF87704.1 - 0.019 15.3 0.1 0.035 14.4 0.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2231) zf-DNL PF05180.7 CDF87706.1 - 2.1e-30 104.2 2.2 3.1e-30 103.6 1.5 1.3 1 0 0 1 1 1 1 DNL zinc finger Elf1 PF05129.8 CDF87706.1 - 0.00076 19.1 1.2 0.0012 18.4 0.8 1.3 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like zinc_ribbon_4 PF13717.1 CDF87706.1 - 0.0044 16.6 2.5 0.22 11.2 0.0 2.6 2 0 0 2 2 2 1 zinc-ribbon domain zinc_ribbon_5 PF13719.1 CDF87706.1 - 0.0052 16.3 2.3 0.24 11.0 0.0 2.6 2 0 0 2 2 2 1 zinc-ribbon domain UPF0167 PF03691.9 CDF87706.1 - 0.025 13.9 0.1 0.032 13.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0167) HypA PF01155.14 CDF87706.1 - 0.032 13.9 0.3 0.045 13.4 0.2 1.4 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Zn-ribbon_8 PF09723.5 CDF87706.1 - 0.058 13.3 3.8 0.066 13.1 1.4 2.0 2 1 0 2 2 2 0 Zinc ribbon domain zf-ZPR1 PF03367.8 CDF87706.1 - 0.096 11.8 3.1 0.18 10.9 2.2 1.6 1 1 0 1 1 1 0 ZPR1 zinc-finger domain TFIIS_C PF01096.13 CDF87706.1 - 0.15 11.7 6.0 2.6 7.7 0.7 2.5 2 1 1 3 3 3 0 Transcription factor S-II (TFIIS) DNA_RNApol_7kD PF03604.8 CDF87706.1 - 0.45 10.0 2.8 15 5.1 0.1 2.3 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Sushi_2 PF09014.5 CDF87706.1 - 0.66 9.7 3.1 1.9 8.3 0.7 2.1 1 1 0 2 2 2 0 Beta-2-glycoprotein-1 fifth domain zf-H2C2_2 PF13465.1 CDF87706.1 - 0.86 10.0 4.8 4.1 7.8 0.1 2.7 1 1 1 2 2 2 0 Zinc-finger double domain Zn_Tnp_IS1595 PF12760.2 CDF87706.1 - 2 8.2 6.0 32 4.4 4.3 2.3 1 1 1 2 2 2 0 Transposase zinc-ribbon domain F-box PF00646.28 CDF87707.1 - 2.1e-07 30.4 1.0 5.7e-05 22.6 0.1 3.1 3 0 0 3 3 3 2 F-box domain F-box-like PF12937.2 CDF87707.1 - 5.9e-06 25.9 1.3 1.2e-05 24.9 0.3 2.1 2 0 0 2 2 2 1 F-box-like MeMO_Hyd_G PF02964.11 CDF87707.1 - 0.13 12.1 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 Methane monooxygenase, hydrolase gamma chain Glyco_hydro_72 PF03198.9 CDF87708.1 - 3.3e-134 446.8 1.5 4.4e-134 446.4 1.1 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.13 CDF87708.1 - 0.00028 20.2 0.1 0.00074 18.7 0.1 1.7 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_cc PF11790.3 CDF87708.1 - 0.06 12.7 0.0 0.092 12.1 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase catalytic core tRNA_anti-codon PF01336.20 CDF87709.1 - 4.7e-08 32.7 0.8 7.5e-08 32.1 0.6 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RPA_C PF08784.6 CDF87709.1 - 0.00014 22.2 1.5 0.00057 20.2 0.0 2.6 2 1 1 3 3 3 1 Replication protein A C terminal DUF4539 PF15072.1 CDF87709.1 - 0.045 13.4 0.1 0.1 12.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4539) LON PF02190.11 CDF87709.1 - 0.085 12.5 0.1 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 ATP-dependent protease La (LON) domain HTH_IclR PF09339.5 CDF87709.1 - 0.12 12.0 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain TPR_11 PF13414.1 CDF87710.1 - 2e-12 46.5 0.0 1e-08 34.6 0.0 4.4 4 1 0 4 4 4 1 TPR repeat TPR_14 PF13428.1 CDF87710.1 - 2.5e-07 30.7 0.0 4 8.3 0.0 5.8 2 2 3 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.1 CDF87710.1 - 5.8e-07 28.8 0.0 0.16 11.8 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.1 CDF87710.1 - 1.4e-06 28.1 0.0 0.032 14.1 0.0 4.7 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.12 CDF87710.1 - 1.7e-05 24.3 0.0 0.82 9.7 0.0 4.5 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.23 CDF87710.1 - 4.6e-05 22.8 0.0 0.52 10.0 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 CDF87710.1 - 0.00013 21.8 0.0 0.044 13.9 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.1 CDF87710.1 - 0.00066 19.9 0.0 1.3 9.4 0.0 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 CDF87710.1 - 0.00083 19.9 0.1 0.25 12.0 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat Myb_DNA-bind_5 PF13873.1 CDF87711.1 - 3.2e-05 23.7 0.3 9.5e-05 22.2 0.2 1.8 1 1 0 1 1 1 1 Myb/SANT-like DNA-binding domain BLOC1_2 PF10046.4 CDF87711.1 - 0.047 13.8 5.6 0.75 9.9 1.1 2.3 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 GFO_IDH_MocA PF01408.17 CDF87714.1 - 1.1e-22 80.7 0.0 2.1e-22 79.8 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 CDF87714.1 - 3.7e-08 33.1 0.0 7.9e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Hydantoinase_B PF02538.9 CDF87715.1 - 1.3e-215 716.6 0.1 1.6e-215 716.3 0.0 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.13 CDF87715.1 - 3.2e-90 302.1 1.0 4.5e-90 301.6 0.1 1.8 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 CDF87715.1 - 1.2e-55 187.7 1.2 1.6e-53 180.8 0.0 2.9 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase N-terminal region HMG_box PF00505.14 CDF87717.1 - 2.4e-11 43.7 2.1 2.4e-11 43.7 1.4 2.1 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.5 CDF87717.1 - 1.1e-08 35.3 1.1 1.1e-08 35.3 0.8 2.1 2 0 0 2 2 2 1 HMG-box domain Mit_KHE1 PF10173.4 CDF87717.1 - 0.39 10.5 3.6 0.63 9.8 2.4 1.5 1 1 0 1 1 1 0 Mitochondrial K+-H+ exchange-related MRP-S28 PF10213.4 CDF87718.1 - 1.2e-47 161.1 3.1 1.7e-47 160.6 1.6 1.7 2 0 0 2 2 2 1 Mitochondrial ribosomal subunit protein Ada3 PF10198.4 CDF87719.1 - 6.5e-45 152.0 2.1 1.3e-44 151.1 1.5 1.5 1 0 0 1 1 1 1 Histone acetyltransferases subunit 3 UQ_con PF00179.21 CDF87720.1 - 1.9e-43 147.2 0.0 2.4e-43 146.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.5 CDF87720.1 - 6.8e-27 92.8 1.6 1e-26 92.2 0.6 1.6 2 0 0 2 2 2 1 Fungal ubiquitin-associated domain RWD PF05773.17 CDF87720.1 - 0.099 12.5 0.1 0.16 11.8 0.0 1.5 1 1 0 1 1 1 0 RWD domain Peptidase_M16 PF00675.15 CDF87721.1 - 6e-50 168.8 0.0 1.5e-49 167.5 0.0 1.7 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 CDF87721.1 - 1.4e-40 138.9 0.0 4.2e-40 137.3 0.0 1.7 2 0 0 2 2 2 1 Peptidase M16 inactive domain CybS PF05328.7 CDF87722.1 - 1.3e-47 160.7 0.0 1.6e-47 160.4 0.0 1.1 1 0 0 1 1 1 1 CybS DUF3185 PF11381.3 CDF87722.1 - 0.089 12.5 0.1 0.17 11.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3185) Sdh_cyt PF01127.17 CDF87722.1 - 0.16 11.7 1.8 0.69 9.7 1.3 1.9 1 1 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit PCI PF01399.22 CDF87723.1 - 0.00017 21.8 0.1 0.00025 21.3 0.0 1.3 1 0 0 1 1 1 1 PCI domain PXA PF02194.10 CDF87724.1 - 0.00013 21.6 0.8 0.0057 16.2 0.0 3.1 2 1 0 2 2 2 1 PXA domain Ribosomal_S18 PF01084.15 CDF87724.1 - 0.039 13.8 0.1 0.096 12.5 0.1 1.7 1 0 0 1 1 1 0 Ribosomal protein S18 PseudoU_synth_2 PF00849.17 CDF87725.1 - 7.4e-18 64.9 0.4 9.5e-17 61.3 0.3 2.0 1 1 0 1 1 1 1 RNA pseudouridylate synthase Hormone_2 PF00123.15 CDF87725.1 - 0.16 11.8 0.2 0.43 10.4 0.1 1.8 1 0 0 1 1 1 0 Peptide hormone Nipped-B_C PF12830.2 CDF87726.1 - 2e-43 148.2 6.9 2.4e-43 147.9 1.3 3.5 4 0 0 4 4 4 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.2 CDF87726.1 - 2e-10 40.4 0.3 6.7e-10 38.7 0.2 2.0 1 0 0 1 1 1 1 HEAT repeat associated with sister chromatid cohesion TFX_C PF14601.1 CDF87726.1 - 0.063 13.0 2.0 3.3 7.5 0.3 2.9 2 0 0 2 2 2 0 DNA_binding protein, TFX, C-term FANCI_S2 PF14676.1 CDF87726.1 - 7.7 6.3 13.4 0.68 9.8 0.2 4.7 4 2 2 6 6 6 0 FANCI solenoid 2 SAS4 PF15460.1 CDF87727.1 - 1.4e-27 95.4 7.4 1.4e-27 95.4 5.1 2.3 2 0 0 2 2 2 1 Something about silencing, SAS, complex subunit 4 PAXIP1_C PF15364.1 CDF87727.1 - 0.05 13.5 2.9 0.26 11.2 0.1 2.6 2 0 0 2 2 2 0 PAXIP1-associated-protein-1 C term PTIP binding protein Metallophos PF00149.23 CDF87728.1 - 1.8e-13 50.3 1.0 2.9e-13 49.6 0.7 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Sec10 PF07393.6 CDF87729.1 - 8.7e-197 655.5 19.7 1.2e-196 655.0 13.7 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec10 HALZ PF02183.13 CDF87731.1 - 0.044 13.5 2.2 0.11 12.2 1.5 1.7 1 0 0 1 1 1 0 Homeobox associated leucine zipper TSC22 PF01166.13 CDF87731.1 - 0.16 11.9 2.8 0.36 10.8 1.9 1.5 1 0 0 1 1 1 0 TSC-22/dip/bun family PRELI PF04707.9 CDF87732.1 - 8.9e-55 184.5 0.0 1.1e-54 184.2 0.0 1.0 1 0 0 1 1 1 1 PRELI-like family UPF0262 PF06793.7 CDF87732.1 - 0.08 12.6 0.0 0.18 11.4 0.0 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0262) zf-DHHC PF01529.15 CDF87733.1 - 5.4e-37 126.8 2.8 5.4e-37 126.8 1.9 1.6 1 1 1 2 2 2 1 DHHC palmitoyltransferase dCMP_cyt_deam_1 PF00383.17 CDF87735.1 - 5.4e-17 61.3 0.1 6.5e-17 61.0 0.1 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.6 CDF87735.1 - 8.4e-11 41.9 0.5 1.5e-10 41.0 0.0 1.5 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.1 CDF87735.1 - 0.0024 17.2 0.5 0.25 10.6 0.1 2.1 1 1 1 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases Peptidase_M24 PF00557.19 CDF87736.1 - 2.3e-46 157.9 0.1 2.8e-46 157.6 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Cpn60_TCP1 PF00118.19 CDF87737.1 - 1.8e-142 475.3 0.7 2.1e-142 475.2 0.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Sec1 PF00995.18 CDF87738.1 - 3.3e-144 481.6 1.8 3.7e-144 481.4 1.2 1.0 1 0 0 1 1 1 1 Sec1 family TIP49 PF06068.8 CDF87739.1 - 1.2e-188 626.8 0.5 1.3e-188 626.6 0.4 1.0 1 0 0 1 1 1 1 TIP49 C-terminus RuvB_N PF05496.7 CDF87739.1 - 6.3e-09 35.2 3.5 0.00012 21.1 0.0 3.1 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA PF00004.24 CDF87739.1 - 6.7e-09 36.0 0.5 5.9e-05 23.2 0.0 3.0 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 CDF87739.1 - 0.0009 19.2 0.0 0.002 18.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDF87739.1 - 0.00098 19.1 0.0 0.27 11.1 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_19 PF13245.1 CDF87739.1 - 0.0042 16.8 0.0 0.018 14.7 0.0 2.2 1 0 0 1 1 1 1 Part of AAA domain Zeta_toxin PF06414.7 CDF87739.1 - 0.011 14.8 0.1 0.027 13.5 0.1 1.6 1 0 0 1 1 1 0 Zeta toxin DnaB_C PF03796.10 CDF87739.1 - 0.027 13.3 0.0 0.049 12.5 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Mg_chelatase PF01078.16 CDF87739.1 - 0.029 13.5 0.1 4.2 6.4 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI CPT PF07931.7 CDF87739.1 - 0.043 13.4 0.0 0.087 12.4 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_5 PF07728.9 CDF87739.1 - 0.049 13.3 0.1 1.6 8.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.21 CDF87739.1 - 0.1 12.0 0.0 14 5.0 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain SIR2 PF02146.12 CDF87740.1 - 1.6e-30 106.1 0.0 3e-30 105.2 0.0 1.4 1 1 0 1 1 1 1 Sir2 family ATP_bind_1 PF03029.12 CDF87741.1 - 1.9e-86 289.4 0.0 2.2e-86 289.2 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_17 PF13207.1 CDF87741.1 - 3.2e-05 24.7 0.1 8.3e-05 23.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain ArgK PF03308.11 CDF87741.1 - 0.00026 19.8 0.0 0.00049 18.9 0.0 1.3 1 0 0 1 1 1 1 ArgK protein AAA_10 PF12846.2 CDF87741.1 - 0.0003 20.3 0.0 0.00076 18.9 0.0 1.6 2 0 0 2 2 2 1 AAA-like domain MMR_HSR1 PF01926.18 CDF87741.1 - 0.00063 19.6 0.0 0.0016 18.3 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 CDF87741.1 - 0.00082 19.5 0.0 0.017 15.2 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_14 PF13173.1 CDF87741.1 - 0.0013 18.6 0.0 0.18 11.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 CDF87741.1 - 0.0035 17.4 0.0 0.0099 16.0 0.0 1.8 1 0 0 1 1 1 1 RNA helicase MobB PF03205.9 CDF87741.1 - 0.0045 16.7 0.0 0.011 15.4 0.0 1.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B KAP_NTPase PF07693.9 CDF87741.1 - 0.0076 15.2 0.0 0.012 14.5 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain AAA_33 PF13671.1 CDF87741.1 - 0.0077 16.1 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CDF87741.1 - 0.0086 16.3 0.0 0.022 15.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain GTP_EFTU PF00009.22 CDF87741.1 - 0.0092 15.4 0.0 0.46 9.8 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.1 CDF87741.1 - 0.025 14.1 0.0 0.05 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 CDF87741.1 - 0.027 13.6 0.0 0.05 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ABC_tran PF00005.22 CDF87741.1 - 0.033 14.5 0.0 0.059 13.6 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Septin PF00735.13 CDF87741.1 - 0.044 12.7 0.0 0.065 12.2 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_30 PF13604.1 CDF87741.1 - 0.049 13.2 0.0 0.18 11.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 CDF87741.1 - 0.055 13.6 0.0 0.65 10.2 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CDF87741.1 - 0.06 13.0 0.0 0.34 10.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.13 CDF87741.1 - 0.063 12.7 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase cobW PF02492.14 CDF87741.1 - 0.065 12.6 0.0 0.97 8.8 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Arch_ATPase PF01637.13 CDF87741.1 - 0.072 12.7 0.0 0.89 9.2 0.0 2.1 2 0 0 2 2 2 0 Archaeal ATPase T2SE PF00437.15 CDF87741.1 - 0.074 11.9 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.1 CDF87741.1 - 0.083 12.8 0.0 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain SRP54 PF00448.17 CDF87741.1 - 0.084 12.2 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain TrwB_AAD_bind PF10412.4 CDF87741.1 - 0.085 11.4 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain DUF87 PF01935.12 CDF87741.1 - 0.12 12.1 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF87 Miro PF08477.8 CDF87741.1 - 0.14 12.6 0.0 2 8.9 0.0 2.5 2 1 1 3 3 2 0 Miro-like protein Zeta_toxin PF06414.7 CDF87741.1 - 0.18 10.8 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin zf-CCCH PF00642.19 CDF87742.1 - 3e-08 33.1 3.5 5.3e-08 32.3 2.4 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Arv1 PF04161.8 CDF87743.1 - 1.6e-76 256.8 10.4 2e-76 256.5 7.2 1.1 1 0 0 1 1 1 1 Arv1-like family PI3Ka PF00613.15 CDF87744.1 - 1.5e-69 232.9 1.8 2.3e-69 232.2 1.2 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.22 CDF87744.1 - 1.1e-46 159.2 0.0 1.8e-45 155.2 0.0 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.19 CDF87744.1 - 3.4e-21 75.5 0.3 8.6e-21 74.2 0.2 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 DEAD PF00270.24 CDF87745.1 - 3.3e-40 137.3 0.6 2.9e-37 127.7 0.1 2.2 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF87745.1 - 1.6e-19 69.5 0.0 5.6e-19 67.7 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDF87745.1 - 1.3e-05 25.1 0.1 4e-05 23.5 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AF0941-like PF14591.1 CDF87745.1 - 0.29 11.1 5.2 0.58 10.2 0.2 2.5 2 0 0 2 2 2 0 AF0941-like ALIX_LYPXL_bnd PF13949.1 CDF87746.1 - 0.034 13.1 0.2 0.083 11.8 0.1 1.6 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV DUF3523 PF12037.3 CDF87746.1 - 0.044 12.7 0.0 0.072 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) CoaE PF01121.15 CDF87747.1 - 7e-59 198.2 0.0 9e-59 197.8 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_17 PF13207.1 CDF87747.1 - 2.7e-08 34.6 0.0 4.3e-08 33.9 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CDF87747.1 - 8.1e-05 22.9 0.1 0.00015 22.0 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CDF87747.1 - 0.00019 21.3 0.0 0.00035 20.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 CDF87747.1 - 0.00054 19.9 0.0 0.00084 19.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain SKI PF01202.17 CDF87747.1 - 0.019 14.8 0.0 0.19 11.6 0.0 2.2 2 1 0 2 2 2 0 Shikimate kinase Cytidylate_kin2 PF13189.1 CDF87747.1 - 0.052 13.4 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase-like family ApbA_C PF08546.6 CDF87748.1 - 2.5e-12 46.8 0.0 1.3e-11 44.6 0.0 2.0 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal SET PF00856.23 CDF87749.1 - 0.072 13.3 0.4 0.3 11.3 0.3 2.1 1 1 0 1 1 1 0 SET domain BPL_LplA_LipB PF03099.14 CDF87750.1 - 1.3e-17 64.0 0.0 2.9e-17 62.8 0.0 1.6 2 0 0 2 2 2 1 Biotin/lipoate A/B protein ligase family FHA PF00498.21 CDF87751.1 - 1.9e-18 66.3 0.3 3e-17 62.4 0.1 2.6 2 0 0 2 2 2 1 FHA domain DUF2205 PF10224.4 CDF87751.1 - 6.5 6.4 14.1 0.74 9.4 0.3 3.5 1 1 2 3 3 3 0 Predicted coiled-coil protein (DUF2205) DASH_Spc19 PF08287.6 CDF87752.1 - 5.5e-36 123.4 15.7 6.2e-36 123.3 10.9 1.0 1 0 0 1 1 1 1 Spc19 DUF465 PF04325.8 CDF87752.1 - 0.044 13.5 2.4 0.044 13.5 1.6 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF465) RNA_pol_Rpb5_C PF01191.14 CDF87752.1 - 0.045 13.3 1.4 0.13 11.8 0.1 2.1 2 0 0 2 2 2 0 RNA polymerase Rpb5, C-terminal domain COX16 PF14138.1 CDF87752.1 - 0.17 12.0 3.9 5.9 7.1 0.3 2.3 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 DUF342 PF03961.8 CDF87752.1 - 2.7 6.3 8.7 1.7 6.9 4.9 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF342) SlyX PF04102.7 CDF87752.1 - 9.4 6.6 7.3 2.4 8.6 0.4 2.8 3 0 0 3 3 3 0 SlyX Rogdi_lz PF10259.4 CDF87753.1 - 3.9e-74 249.1 2.3 4.4e-74 249.0 1.6 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein Coq4 PF05019.8 CDF87754.1 - 4.3e-95 316.8 0.0 5.3e-95 316.5 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Transp_cyt_pur PF02133.10 CDF87755.1 - 1.6e-71 241.1 42.5 2.2e-71 240.6 29.4 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin APG9 PF04109.11 CDF87755.1 - 0.3 9.9 3.9 0.11 11.4 0.5 1.7 2 0 0 2 2 2 0 Autophagy protein Apg9 Cation_efflux PF01545.16 CDF87756.1 - 1.8e-58 197.9 9.2 1.8e-58 197.9 6.4 2.9 2 2 0 2 2 2 1 Cation efflux family SelP_N PF04592.9 CDF87756.1 - 5.3 6.3 21.2 4.8 6.4 5.4 2.3 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Topoisom_bac PF01131.15 CDF87757.1 - 1.7e-93 313.6 0.0 2.2e-93 313.2 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.17 CDF87757.1 - 2.7e-20 72.2 0.0 6.9e-20 70.9 0.0 1.7 2 0 0 2 2 2 1 Toprim domain EST1_DNA_bind PF10373.4 CDF87758.1 - 7.9e-55 186.0 0.6 1.6e-54 185.0 0.4 1.5 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.4 CDF87758.1 - 1e-22 80.4 1.9 3e-22 79.0 0.3 2.3 2 0 0 2 2 2 1 Telomerase activating protein Est1 Zn_clus PF00172.13 CDF87759.1 - 1.4e-08 34.4 7.6 2.7e-08 33.5 5.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4551 PF15087.1 CDF87759.1 - 0.89 7.8 5.8 2.1 6.5 4.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) RXT2_N PF08595.6 CDF87759.1 - 9.3 6.0 12.7 0.77 9.5 0.5 2.5 2 0 0 2 2 2 0 RXT2-like, N-terminal Aminotran_5 PF00266.14 CDF87760.1 - 8.6e-13 47.7 0.0 1.1e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V PIP5K PF01504.13 CDF87761.1 - 6.2e-83 277.7 0.5 6.2e-83 277.7 0.3 1.9 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase TFIIA PF03153.8 CDF87761.1 - 8.3 6.1 22.3 12 5.6 15.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CYSTM PF12734.2 CDF87762.1 - 9.5e-09 35.1 24.8 9.5e-09 35.1 17.2 2.7 1 1 1 2 2 2 2 Cysteine-rich TM module stress tolerance WWbp PF10349.4 CDF87762.1 - 3 8.7 9.4 3.3 8.6 6.5 1.1 1 0 0 1 1 1 0 WW-domain ligand protein W2 PF02020.13 CDF87763.1 - 3.1e-15 55.8 5.2 9.2e-15 54.3 3.6 1.9 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.19 CDF87763.1 - 3.3e-12 45.3 21.3 8.6e-07 28.1 5.1 4.3 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.18 CDF87763.1 - 1.4e-07 31.1 0.0 2.8e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyl transferase Fucokinase PF07959.7 CDF87763.1 - 0.0025 16.4 1.3 0.013 14.0 0.9 2.0 1 1 0 1 1 1 1 L-fucokinase NTP_transf_3 PF12804.2 CDF87763.1 - 0.0039 17.2 0.0 0.0078 16.3 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.1 CDF87763.1 - 0.021 14.3 22.3 0.24 10.9 5.0 4.0 1 1 2 3 3 3 0 Hexapeptide repeat of succinyl-transferase Ras PF00071.17 CDF87764.1 - 1.2e-50 171.1 0.0 1.4e-50 170.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDF87764.1 - 1.3e-13 51.4 0.0 1.7e-13 51.0 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDF87764.1 - 2.6e-07 30.0 0.0 3.4e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Cpn60_TCP1 PF00118.19 CDF87765.1 - 2.5e-141 471.6 12.4 2.8e-141 471.4 8.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Fungal_trans_2 PF11951.3 CDF87766.1 - 1.2e-12 47.2 0.4 1.2e-12 47.2 0.3 2.4 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF87766.1 - 1.8e-08 34.1 13.1 3.2e-08 33.3 9.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CD20 PF04103.10 CDF87766.1 - 0.61 9.9 2.1 8.7 6.2 0.7 2.8 3 0 0 3 3 3 0 CD20-like family Med15 PF09606.5 CDF87766.1 - 2.3 6.3 72.6 4.1 5.4 50.3 1.5 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RR_TM4-6 PF06459.7 CDF87766.1 - 8.5 6.1 16.3 3 7.6 4.3 2.4 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Aha1_N PF09229.6 CDF87767.1 - 4.6e-38 130.1 0.0 1.2e-37 128.7 0.0 1.7 2 0 0 2 2 2 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.6 CDF87767.1 - 4.1e-13 49.5 0.1 7.1e-13 48.7 0.1 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Pox_A12 PF04651.8 CDF87767.1 - 0.03 14.4 0.2 0.048 13.7 0.1 1.2 1 0 0 1 1 1 0 Poxvirus A12 protein Hydrolase_6 PF13344.1 CDF87768.1 - 9.1e-24 83.2 0.0 1.9e-23 82.2 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 CDF87768.1 - 4.1e-12 45.6 0.0 1e-11 44.3 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 CDF87768.1 - 0.074 13.4 0.0 0.9 9.8 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase zf-C2H2 PF00096.21 CDF87769.1 - 1.4e-09 37.7 12.5 6.5e-05 23.0 1.1 3.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CDF87769.1 - 1.8e-08 34.2 9.3 7.3e-07 29.1 4.4 2.9 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 CDF87769.1 - 2e-07 30.8 13.1 0.0035 17.5 1.3 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.2 CDF87769.1 - 0.0013 18.8 4.3 1.2 9.4 0.2 3.2 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 CDF87769.1 - 0.19 11.6 7.0 0.39 10.6 0.4 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CDF87769.1 - 9.3 6.5 10.0 1.5 9.0 0.3 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Rad9_Rad53_bind PF08605.5 CDF87770.1 - 1.1e-38 132.0 0.0 1.9e-38 131.2 0.0 1.4 1 0 0 1 1 1 1 Fungal Rad9-like Rad53-binding BRCT PF00533.21 CDF87770.1 - 3.5e-10 39.8 0.1 1.1e-09 38.2 0.1 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain TetR PF13972.1 CDF87770.1 - 0.089 12.2 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial transcriptional repressor Septin PF00735.13 CDF87772.1 - 2.3e-74 249.9 0.4 3.6e-74 249.3 0.3 1.3 1 0 0 1 1 1 1 Septin AAA_23 PF13476.1 CDF87772.1 - 0.0015 18.8 0.6 0.0093 16.3 0.4 2.0 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.22 CDF87772.1 - 0.006 16.8 0.0 0.014 15.7 0.0 1.6 1 0 0 1 1 1 1 ABC transporter FtsK_SpoIIIE PF01580.13 CDF87772.1 - 0.0067 15.9 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family MMR_HSR1 PF01926.18 CDF87772.1 - 0.007 16.3 0.0 0.019 14.9 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.11 CDF87772.1 - 0.0092 15.1 0.0 0.021 13.9 0.0 1.6 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.18 CDF87772.1 - 0.013 15.3 2.0 0.12 12.1 0.1 2.4 2 0 0 2 2 2 0 Dynamin family Glutaredoxin2_C PF04399.8 CDF87772.1 - 0.025 14.1 0.7 0.25 10.9 0.2 2.3 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain AAA_24 PF13479.1 CDF87772.1 - 0.031 13.8 0.7 0.15 11.6 0.0 2.5 2 1 0 2 2 2 0 AAA domain VirE PF05272.6 CDF87772.1 - 0.063 12.7 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 Virulence-associated protein E DUF258 PF03193.11 CDF87772.1 - 0.083 12.0 0.0 0.17 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_10 PF12846.2 CDF87772.1 - 0.09 12.1 0.0 0.3 10.4 0.0 1.8 2 0 0 2 2 2 0 AAA-like domain Miro PF08477.8 CDF87772.1 - 0.1 13.1 0.0 0.31 11.5 0.0 1.9 2 0 0 2 2 2 0 Miro-like protein F-box PF00646.28 CDF87774.1 - 0.00062 19.3 4.1 0.0013 18.2 1.6 2.3 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.2 CDF87774.1 - 0.0085 15.8 1.0 0.017 14.8 0.7 1.5 1 0 0 1 1 1 1 F-box-like PRKCSH-like PF12999.2 CDF87775.1 - 2e-38 131.6 1.6 2e-38 131.6 1.1 2.0 2 0 0 2 2 2 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.1 CDF87775.1 - 1.7e-17 63.2 13.8 3.2e-17 62.4 6.2 3.4 3 1 0 3 3 3 1 Glucosidase II beta subunit-like protein GrpE PF01025.14 CDF87775.1 - 0.076 12.5 12.9 2.7 7.4 0.1 3.1 3 0 0 3 3 3 0 GrpE Ldl_recept_a PF00057.13 CDF87775.1 - 0.083 12.8 17.1 0.77 9.7 2.9 2.6 1 1 1 2 2 2 0 Low-density lipoprotein receptor domain class A Med9 PF07544.8 CDF87775.1 - 2 8.1 7.5 6.2 6.6 1.3 2.7 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Phage_GP20 PF06810.6 CDF87775.1 - 2.8 7.3 14.7 0.041 13.3 0.5 3.6 3 1 0 3 3 3 0 Phage minor structural protein GP20 TMF_DNA_bd PF12329.3 CDF87775.1 - 6.4 6.6 15.8 0.39 10.5 2.9 3.1 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Svf1 PF08622.5 CDF87776.1 - 2.1e-93 312.8 0.3 2.6e-93 312.5 0.2 1.1 1 0 0 1 1 1 1 Svf1-like LuxS PF02664.10 CDF87776.1 - 0.033 13.7 0.0 0.063 12.8 0.0 1.5 1 0 0 1 1 1 0 S-Ribosylhomocysteinase (LuxS) CRF1 PF10380.4 CDF87778.1 - 3.1e-34 117.9 1.3 3.1e-34 117.9 0.9 4.6 5 2 0 5 5 5 1 Transcription factor CRF1 WD40 PF00400.27 CDF87779.1 - 1.7e-64 211.5 17.5 2e-08 33.8 0.0 12.3 13 0 0 13 13 13 9 WD domain, G-beta repeat Utp13 PF08625.6 CDF87779.1 - 5.6e-47 158.9 2.7 9.3e-47 158.2 1.9 1.4 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain Nup160 PF11715.3 CDF87779.1 - 3.1e-07 28.9 7.6 0.027 12.6 0.1 5.8 2 2 3 5 5 5 5 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 CDF87779.1 - 3.2e-06 26.1 0.4 1.4 7.5 0.0 4.7 3 1 1 4 4 4 3 Nup133 N terminal like BBS2_Mid PF14783.1 CDF87779.1 - 0.014 15.1 0.1 0.41 10.4 0.0 3.2 3 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Rsa3 PF14615.1 CDF87780.1 - 1.8e-20 71.9 0.3 3e-20 71.2 0.2 1.4 1 0 0 1 1 1 1 Ribosome-assembly protein 3 DndB PF14072.1 CDF87780.1 - 0.0018 17.4 0.1 0.0022 17.1 0.1 1.1 1 0 0 1 1 1 1 DNA-sulfur modification-associated Hpt PF01627.18 CDF87780.1 - 0.015 15.2 0.4 0.12 12.4 0.0 2.3 2 0 0 2 2 2 0 Hpt domain ATP-synt_D PF01813.12 CDF87780.1 - 0.064 12.8 1.8 0.089 12.3 1.2 1.4 1 1 0 1 1 1 0 ATP synthase subunit D DUF966 PF06136.8 CDF87780.1 - 1.6 8.0 7.2 2.1 7.6 5.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) DUF2664 PF10867.3 CDF87780.1 - 2.4 8.8 7.0 9.7 6.8 0.3 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF2664) VIT1 PF01988.14 CDF87781.1 - 5.9e-57 192.5 0.4 7e-57 192.3 0.3 1.1 1 0 0 1 1 1 1 VIT family Histone PF00125.19 CDF87782.1 - 5e-21 74.6 0.3 6.8e-21 74.1 0.2 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 CDF87782.1 - 1.6e-05 24.8 0.1 3.4e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.8 CDF87782.1 - 0.0035 17.5 0.0 0.0062 16.7 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Mitofilin PF09731.4 CDF87782.1 - 0.019 13.6 2.5 0.022 13.4 1.7 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Herpes_glycop_H PF02489.11 CDF87782.1 - 0.038 12.0 0.5 0.037 12.0 0.4 1.0 1 0 0 1 1 1 0 Herpesvirus glycoprotein H Histone PF00125.19 CDF87783.1 - 3.8e-26 91.0 0.0 4.9e-26 90.6 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 CDF87783.1 - 4.6e-06 26.6 0.0 6.6e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CFIA_Pcf11 PF11526.3 CDF87787.1 - 8.9e-26 89.8 0.6 8.9e-26 89.8 0.4 2.4 2 0 0 2 2 2 1 Subunit of cleavage factor IA Pcf11 VHS PF00790.14 CDF87787.1 - 0.0025 17.4 0.0 0.01 15.4 0.0 2.1 1 0 0 1 1 1 1 VHS domain EIF4E-T PF10477.4 CDF87787.1 - 0.0046 15.8 7.7 0.0073 15.1 5.3 1.3 1 0 0 1 1 1 1 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E AAA_23 PF13476.1 CDF87787.1 - 0.084 13.1 8.1 0.17 12.1 5.6 1.6 1 0 0 1 1 1 0 AAA domain zf-RING_2 PF13639.1 CDF87787.1 - 0.092 12.5 0.2 0.66 9.8 0.0 2.4 2 0 0 2 2 2 0 Ring finger domain zf-C2H2_4 PF13894.1 CDF87787.1 - 0.83 10.1 6.9 0.91 10.0 0.3 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CDF87787.1 - 1.5 9.2 7.9 17 5.8 0.1 3.7 3 0 0 3 3 3 0 Zinc-finger double domain BAF1_ABF1 PF04684.8 CDF87787.1 - 2.1 7.1 21.3 3.5 6.3 14.8 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Mito_carr PF00153.22 CDF87788.1 - 1.2e-33 114.6 0.6 2.8e-15 55.7 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3228 PF11539.3 CDF87788.1 - 0.11 11.5 0.0 0.21 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3228) Sugar_tr PF00083.19 CDF87789.1 - 6.9e-98 328.1 19.2 8.2e-98 327.8 13.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CDF87789.1 - 1.2e-26 93.3 19.6 1.2e-26 93.3 13.6 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CDF87789.1 - 1.4e-08 33.5 15.9 9.6e-05 20.9 0.5 2.3 2 0 0 2 2 2 2 MFS/sugar transport protein OATP PF03137.15 CDF87789.1 - 0.41 8.6 8.0 0.067 11.2 1.3 2.2 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DNA_binding_1 PF01035.15 CDF87790.1 - 1.3e-25 88.9 0.1 2.1e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_4 PF02390.12 CDF87791.1 - 2.2e-59 199.8 0.0 3.1e-59 199.3 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_31 PF13847.1 CDF87791.1 - 6.1e-05 22.6 0.0 0.00014 21.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDF87791.1 - 9.5e-05 22.9 0.0 0.00015 22.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CDF87791.1 - 0.001 19.0 0.0 0.0019 18.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDF87791.1 - 0.018 15.4 0.0 0.04 14.2 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.9 CDF87791.1 - 0.03 13.7 0.0 0.086 12.2 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.13 CDF87791.1 - 0.032 13.3 0.0 0.077 12.1 0.0 1.7 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 CDF87791.1 - 0.047 14.1 0.0 0.14 12.6 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain DOT1 PF08123.8 CDF87791.1 - 0.1 11.8 0.0 0.28 10.4 0.0 1.7 1 1 1 2 2 2 0 Histone methylation protein DOT1 FmrO PF07091.6 CDF87791.1 - 0.12 11.3 0.0 0.22 10.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Ribosomal_L10 PF00466.15 CDF87792.1 - 8.2e-11 41.7 0.0 1.3e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 Peptidase_C97 PF05903.9 CDF87793.1 - 0.044 13.5 0.1 0.078 12.7 0.1 1.4 1 0 0 1 1 1 0 PPPDE putative peptidase domain Spore_II_R PF09551.5 CDF87793.1 - 0.68 9.9 2.4 1.9 8.4 1.2 2.1 2 1 0 2 2 2 0 Stage II sporulation protein R (spore_II_R) DUF3767 PF12597.3 CDF87794.1 - 1.4e-43 147.2 0.3 2.1e-43 146.7 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3767) DUF3353 PF11833.3 CDF87794.1 - 0.15 11.5 0.4 0.27 10.6 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3353) Sel1 PF08238.7 CDF87795.1 - 1.7e-37 126.9 24.8 1.7e-05 25.3 0.1 8.2 7 1 0 7 7 7 7 Sel1 repeat Aminotran_1_2 PF00155.16 CDF87796.1 - 6.4e-72 242.4 0.0 8.5e-72 242.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 CDF87796.1 - 4.7e-08 31.7 0.0 8.8e-08 30.8 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 CDF87796.1 - 2e-06 26.8 0.3 3.8e-06 25.8 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 CDF87796.1 - 0.0061 15.6 0.3 0.06 12.3 0.2 2.0 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Reticulon PF02453.12 CDF87797.1 - 4.3e-37 127.3 3.5 5.8e-37 126.8 2.4 1.1 1 0 0 1 1 1 1 Reticulon Aconitase PF00330.15 CDF87798.1 - 4.7e-69 233.0 0.0 8.7e-42 143.1 0.0 2.1 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 CDF87798.1 - 2.8e-29 101.8 0.0 7.4e-29 100.5 0.0 1.7 1 0 0 1 1 1 1 Aconitase C-terminal domain Porphobil_deam PF01379.15 CDF87799.1 - 6e-84 280.2 0.0 7.7e-84 279.9 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.10 CDF87799.1 - 2.4e-18 65.9 0.2 4.1e-18 65.2 0.1 1.4 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Na_Ca_ex PF01699.19 CDF87801.1 - 3.7e-51 172.4 31.2 5.9e-27 93.9 3.9 3.4 2 1 1 3 3 3 2 Sodium/calcium exchanger protein RSN1_TM PF13967.1 CDF87801.1 - 0.011 15.3 0.8 0.011 15.3 0.6 3.2 3 0 0 3 3 3 0 Late exocytosis, associated with Golgi transport Flavokinase PF01687.12 CDF87802.1 - 3e-30 104.6 0.0 5.1e-30 103.9 0.0 1.3 1 0 0 1 1 1 1 Riboflavin kinase GLE1 PF07817.8 CDF87803.1 - 6e-87 290.8 0.1 6e-87 290.8 0.1 1.8 2 0 0 2 2 2 1 GLE1-like protein CAF-1_p150 PF11600.3 CDF87803.1 - 0.00011 21.6 35.7 0.0002 20.8 24.7 1.4 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal Ribosomal_L5_C PF00673.16 CDF87804.1 - 2.6e-22 78.3 0.0 4.5e-22 77.5 0.0 1.4 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 CDF87804.1 - 1.1e-05 25.0 0.0 6.8e-05 22.5 0.0 2.2 2 0 0 2 2 2 1 Ribosomal protein L5 MRP-S33 PF08293.6 CDF87805.1 - 1.9e-31 107.8 0.2 2.4e-31 107.5 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Gpi1 PF05024.10 CDF87806.1 - 1.1e-53 181.7 14.8 1.1e-53 181.7 10.2 2.2 2 0 0 2 2 2 1 N-acetylglucosaminyl transferase component (Gpi1) DUF3043 PF11241.3 CDF87806.1 - 0.23 11.0 0.4 0.52 9.8 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) Ion_trans PF00520.26 CDF87807.1 - 1.8e-93 311.3 101.7 5.5e-36 123.6 1.7 5.8 5 1 0 5 5 5 4 Ion transport protein PKD_channel PF08016.7 CDF87807.1 - 0.00099 17.6 5.5 0.00099 17.6 3.8 8.0 7 2 0 7 7 7 4 Polycystin cation channel EF-hand_1 PF00036.27 CDF87807.1 - 0.0092 15.2 0.0 0.087 12.1 0.0 2.6 2 0 0 2 2 2 1 EF hand Myc_N PF01056.13 CDF87807.1 - 0.071 12.2 0.4 0.15 11.1 0.2 1.4 1 0 0 1 1 1 0 Myc amino-terminal region AA_permease_2 PF13520.1 CDF87808.1 - 3e-57 194.0 40.5 3.6e-57 193.8 28.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CDF87808.1 - 1.2e-20 73.2 35.7 4.1e-20 71.5 24.8 1.7 1 1 0 1 1 1 1 Amino acid permease CRM1_C PF08767.6 CDF87809.1 - 3.5e-129 430.3 4.0 3.5e-129 430.3 2.7 2.7 2 1 0 2 2 2 1 CRM1 C terminal Xpo1 PF08389.7 CDF87809.1 - 7.9e-38 129.6 5.1 7.9e-38 129.6 3.5 4.0 5 0 0 5 5 5 1 Exportin 1-like protein IBN_N PF03810.14 CDF87809.1 - 3.6e-14 52.4 0.3 2.4e-13 49.8 0.0 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain Ribosomal_L3 PF00297.17 CDF87810.1 - 3.7e-41 141.2 1.1 5.5e-40 137.4 0.8 2.0 1 1 0 1 1 1 1 Ribosomal protein L3 Ribosomal_L6 PF00347.18 CDF87811.1 - 1.3e-26 92.8 3.0 4.3e-14 52.7 0.3 2.3 2 0 0 2 2 2 2 Ribosomal protein L6 Ribosomal_S4 PF00163.14 CDF87812.1 - 1.1e-23 83.4 1.7 1.7e-23 82.7 1.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 CDF87812.1 - 1.5e-12 46.7 0.0 3e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 S4 domain Herpes_LAMP2 PF06126.6 CDF87812.1 - 0.027 12.9 0.1 0.031 12.6 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus Latent membrane protein 2 SKG6 PF08693.5 CDF87813.1 - 6.8e-10 38.0 6.0 6.8e-10 38.0 4.2 1.8 2 0 0 2 2 2 1 Transmembrane alpha-helix domain DUF4448 PF14610.1 CDF87813.1 - 0.00019 20.9 0.0 0.00054 19.5 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Adeno_E3_CR2 PF02439.10 CDF87813.1 - 0.054 13.0 0.3 0.092 12.3 0.2 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 EphA2_TM PF14575.1 CDF87813.1 - 0.054 13.8 0.0 0.31 11.4 0.0 2.5 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Rax2 PF12768.2 CDF87813.1 - 0.077 12.1 0.0 0.24 10.5 0.0 1.8 2 0 0 2 2 2 0 Cortical protein marker for cell polarity p53-inducible11 PF14936.1 CDF87813.1 - 0.19 11.6 0.0 0.33 10.8 0.0 1.3 1 0 0 1 1 1 0 Tumour protein p53-inducible protein 11 Prominin PF05478.6 CDF87813.1 - 0.73 7.2 10.1 1.3 6.4 7.0 1.3 1 0 0 1 1 1 0 Prominin DUF883 PF05957.8 CDF87813.1 - 1.3 9.4 3.9 25 5.3 1.7 2.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Tweety PF04906.8 CDF87813.1 - 4.8 5.4 5.6 13 4.0 4.0 1.6 2 0 0 2 2 2 0 Tweety ILVD_EDD PF00920.16 CDF87814.1 - 2e-202 673.2 0.0 2.3e-202 673.0 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family SET_assoc PF11767.3 CDF87815.1 - 0.088 12.1 0.2 0.17 11.1 0.1 1.5 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated WD40 PF00400.27 CDF87816.1 - 5.5e-07 29.2 0.4 0.11 12.4 0.0 3.6 3 0 0 3 3 3 2 WD domain, G-beta repeat WD40 PF00400.27 CDF87817.1 - 3.7e-15 55.1 5.4 0.00011 21.9 0.0 5.8 6 0 0 6 6 6 3 WD domain, G-beta repeat Apc4_WD40 PF12894.2 CDF87817.1 - 0.0016 17.9 0.0 0.013 14.9 0.0 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Pex24p PF06398.6 CDF87818.1 - 2e-72 243.9 0.0 3.1e-72 243.3 0.0 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Reticulon PF02453.12 CDF87818.1 - 0.043 13.4 5.2 0.48 10.0 0.6 2.5 2 0 0 2 2 2 0 Reticulon NdhL PF10716.4 CDF87818.1 - 0.54 10.0 7.0 0.83 9.4 0.8 2.4 2 0 0 2 2 2 0 NADH dehydrogenase transmembrane subunit PRA1 PF03208.14 CDF87818.1 - 2.3 7.5 7.8 2.3 7.5 0.7 2.2 2 0 0 2 2 2 0 PRA1 family protein Lectin_C PF00059.16 CDF87819.1 - 0.011 16.4 1.4 0.32 11.6 0.4 2.7 2 0 0 2 2 2 0 Lectin C-type domain DIE2_ALG10 PF04922.7 CDF87820.1 - 1.2e-126 422.8 32.5 2.1e-126 421.9 22.5 1.4 1 0 0 1 1 1 1 DIE2/ALG10 family SMI1_KNR4 PF09346.5 CDF87821.1 - 7.6e-34 116.5 0.0 4.3e-33 114.0 0.0 2.2 1 1 1 2 2 2 1 SMI1 / KNR4 family (SUKH-1) SLT_L PF14718.1 CDF87821.1 - 0.067 12.9 0.2 0.18 11.6 0.1 1.7 1 0 0 1 1 1 0 Soluble lytic murein transglycosylase L domain Spo12 PF05032.7 CDF87822.1 - 3.5e-19 68.0 3.8 3.5e-19 68.0 2.6 1.8 2 0 0 2 2 2 1 Spo12 family Band_7 PF01145.20 CDF87823.1 - 8.2e-22 77.9 0.4 1.4e-21 77.1 0.3 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family E_Pc_C PF06752.7 CDF87823.1 - 0.04 13.4 1.0 0.057 12.9 0.0 1.7 2 0 0 2 2 2 0 Enhancer of Polycomb C-terminus Ank PF00023.25 CDF87824.1 - 4.5e-40 133.4 0.2 1.2e-08 34.3 0.0 6.1 6 0 0 6 6 6 6 Ankyrin repeat Ank_2 PF12796.2 CDF87824.1 - 2.6e-39 133.4 0.1 1.2e-14 54.4 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CDF87824.1 - 1.1e-37 127.7 2.7 3.8e-09 36.8 0.0 5.2 2 1 4 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.1 CDF87824.1 - 4.1e-34 115.8 0.8 4.3e-10 39.4 0.0 5.7 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDF87824.1 - 1.8e-32 108.1 0.1 4.8e-06 26.3 0.0 6.2 6 0 0 6 6 6 6 Ankyrin repeat Shal-type PF11601.3 CDF87824.1 - 0.014 14.8 0.1 2.9 7.4 0.0 2.9 3 0 0 3 3 3 0 Shal-type voltage-gated potassium channels Ank_2 PF12796.2 CDF87825.1 - 5.9e-29 100.2 2.4 4.6e-15 55.7 0.1 3.5 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) SPX PF03105.14 CDF87825.1 - 1.6e-27 97.0 14.3 5.3e-16 59.2 5.7 2.3 1 1 1 2 2 2 2 SPX domain Ank PF00023.25 CDF87825.1 - 2.2e-22 77.6 10.6 1.6e-05 24.4 0.0 6.9 7 0 0 7 7 7 5 Ankyrin repeat Ank_4 PF13637.1 CDF87825.1 - 5.9e-22 77.6 2.0 1.4e-07 31.7 0.0 4.7 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDF87825.1 - 2.4e-21 73.6 3.3 0.00089 19.2 0.0 6.9 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.1 CDF87825.1 - 1.6e-20 72.6 8.8 1.3e-05 25.2 0.0 6.4 2 2 4 6 6 6 4 Ankyrin repeats (many copies) Glyco_hydro_53 PF07745.8 CDF87825.1 - 0.11 11.2 0.0 0.2 10.4 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 53 AA_permease_2 PF13520.1 CDF87826.1 - 1.9e-65 221.0 43.6 2.4e-65 220.7 30.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CDF87826.1 - 9e-20 70.4 39.9 1.6e-19 69.6 27.7 1.3 1 1 0 1 1 1 1 Amino acid permease BRCT PF00533.21 CDF87827.1 - 2.2e-20 72.5 7.9 5.3e-07 29.6 0.0 6.1 6 0 0 6 6 6 3 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 CDF87827.1 - 4.9e-19 67.9 0.2 8.3e-13 47.9 0.0 3.4 2 0 0 2 2 2 2 twin BRCT domain FAD_binding_6 PF00970.19 CDF87828.1 - 2.5e-10 40.3 0.0 4.4e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Globin PF00042.17 CDF87828.1 - 4.2e-10 39.9 0.1 5.9e-09 36.2 0.0 2.6 3 0 0 3 3 3 1 Globin NAD_binding_1 PF00175.16 CDF87828.1 - 1.5e-05 25.5 0.0 9.4e-05 22.9 0.0 2.3 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain Protoglobin PF11563.3 CDF87828.1 - 0.0022 17.6 0.4 0.0081 15.8 0.1 2.1 2 1 0 2 2 2 1 Protoglobin NAD_binding_6 PF08030.7 CDF87828.1 - 0.052 13.4 0.1 0.15 11.9 0.0 1.8 1 1 0 1 1 1 0 Ferric reductase NAD binding domain ApoO PF09769.4 CDF87829.1 - 2.7e-39 134.4 0.0 4.3e-39 133.7 0.0 1.3 1 0 0 1 1 1 1 Apolipoprotein O Kelch_3 PF13415.1 CDF87833.1 - 3.3e-37 125.8 0.5 1.6e-07 31.3 0.0 6.0 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.1 CDF87833.1 - 1.1e-31 108.2 5.6 7.5e-05 22.5 0.0 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.1 CDF87833.1 - 1.1e-30 105.1 7.3 2.3e-06 27.2 0.1 6.7 5 2 1 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.1 CDF87833.1 - 3.1e-23 80.9 5.1 2.3e-05 24.3 0.1 6.5 5 1 1 6 6 6 5 Kelch motif Kelch_1 PF01344.20 CDF87833.1 - 6.1e-21 73.6 0.3 2.6e-05 23.6 0.0 5.7 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.10 CDF87833.1 - 2.5e-12 46.0 4.6 0.02 14.6 0.0 6.4 6 1 0 6 6 6 3 Kelch motif Collagen PF01391.13 CDF87833.1 - 0.0012 18.3 18.8 0.0012 18.3 13.0 2.8 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) DUF3584 PF12128.3 CDF87833.1 - 3.9 4.6 42.5 0.21 8.9 22.4 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF3584) CHD5 PF04420.9 CDF87833.1 - 4.3 6.9 8.9 3.3 7.3 2.6 2.6 2 0 0 2 2 2 0 CHD5-like protein IncA PF04156.9 CDF87833.1 - 6.5 6.2 52.8 4.3 6.8 3.8 4.7 1 1 2 4 4 4 0 IncA protein PFK PF00365.15 CDF87837.1 - 6.6e-170 563.3 0.3 3.3e-124 413.4 0.3 2.1 2 0 0 2 2 2 2 Phosphofructokinase IlvC PF01450.14 CDF87838.1 - 8.4e-48 161.9 0.0 1.5e-47 161.1 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain IlvN PF07991.7 CDF87838.1 - 1.9e-44 150.9 0.0 2.7e-44 150.4 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_2 PF03446.10 CDF87838.1 - 0.086 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Phage_pRha PF09669.5 CDF87840.1 - 0.023 15.0 0.1 0.53 10.6 0.0 2.2 2 0 0 2 2 2 0 Phage regulatory protein Rha (Phage_pRha) MRP-S26 PF14943.1 CDF87840.1 - 0.12 11.9 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 eIF2A PF08662.6 CDF87841.1 - 2.8e-76 255.5 0.0 5.5e-76 254.6 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.27 CDF87841.1 - 0.00023 20.9 2.6 2.3 8.2 0.2 4.6 4 0 0 4 4 4 2 WD domain, G-beta repeat SBP_bac_11 PF13531.1 CDF87841.1 - 0.031 13.8 0.1 0.21 11.1 0.1 2.1 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein AA_permease_2 PF13520.1 CDF87842.1 - 1.9e-84 283.6 47.9 2.3e-84 283.3 33.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CDF87842.1 - 4.6e-19 68.1 41.8 7.4e-19 67.4 29.0 1.2 1 1 0 1 1 1 1 Amino acid permease SIR2 PF02146.12 CDF87843.1 - 6.7e-34 117.1 0.0 5.6e-33 114.1 0.0 2.0 1 1 0 1 1 1 1 Sir2 family Zn-ribbon_8 PF09723.5 CDF87843.1 - 0.097 12.6 0.1 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 Zinc ribbon domain Bromodomain PF00439.20 CDF87844.1 - 4.6e-28 96.9 3.1 5e-14 51.9 0.2 2.5 2 0 0 2 2 2 2 Bromodomain BAH PF01426.13 CDF87844.1 - 5.2e-22 77.8 0.3 1.4e-21 76.4 0.1 1.9 2 0 0 2 2 2 1 BAH domain Beta_protein PF14350.1 CDF87844.1 - 0.015 14.4 0.0 0.037 13.2 0.0 1.5 1 0 0 1 1 1 0 Beta protein Gal-bind_lectin PF00337.17 CDF87844.1 - 0.09 12.1 0.1 1.6 8.0 0.1 2.3 2 0 0 2 2 2 0 Galactoside-binding lectin PBP1_TM PF14812.1 CDF87844.1 - 1.5 9.2 12.2 3.3 8.0 0.1 3.3 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Lyase_1 PF00206.15 CDF87845.1 - 2e-23 83.0 0.0 3.3e-23 82.3 0.0 1.4 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.4 CDF87845.1 - 1.7e-17 63.1 0.0 8e-17 61.0 0.0 2.2 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus DUF1331 PF07048.6 CDF87845.1 - 0.046 13.1 0.0 0.098 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1331) Folliculin PF11704.3 CDF87846.1 - 4e-53 179.4 0.3 4.8e-53 179.1 0.2 1.1 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport Atg14 PF10186.4 CDF87847.1 - 3.1e-05 23.0 6.3 4.8e-05 22.4 4.4 1.3 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 Metallophos PF00149.23 CDF87848.1 - 5.8e-09 35.6 0.9 1.3e-08 34.5 0.3 2.0 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 CDF87848.1 - 7e-06 25.9 0.0 2.4e-05 24.2 0.0 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Strep_SA_rep PF06696.6 CDF87849.1 - 0.04 13.6 0.2 0.058 13.1 0.1 1.3 1 0 0 1 1 1 0 Streptococcal surface antigen repeat Pkinase PF00069.20 CDF87850.1 - 6e-67 225.5 0.1 9.6e-66 221.5 0.0 2.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF87850.1 - 1.3e-48 165.3 0.2 8.1e-46 156.1 0.0 2.6 2 1 1 3 3 3 2 Protein tyrosine kinase Ras_bdg_2 PF14847.1 CDF87850.1 - 8.2e-35 118.9 0.0 2.4e-34 117.3 0.0 1.9 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_2 PF07647.12 CDF87850.1 - 1.8e-09 37.2 0.0 5.7e-09 35.6 0.0 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.25 CDF87850.1 - 1.2e-08 34.9 0.0 3.2e-08 33.6 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.1 CDF87850.1 - 1.8e-06 27.1 0.1 0.00021 20.3 0.0 3.0 3 0 0 3 3 3 1 Kinase-like EF-hand_6 PF13405.1 CDF87851.1 - 1.2e-08 34.0 0.5 0.0045 16.7 0.0 3.8 3 1 1 4 4 4 2 EF-hand domain EF-hand_7 PF13499.1 CDF87851.1 - 4.6e-08 33.0 3.1 0.0012 18.9 0.1 3.1 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 CDF87851.1 - 1.8e-05 23.7 0.0 0.66 9.4 0.0 4.2 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.1 CDF87851.1 - 0.00066 19.2 0.0 0.26 10.9 0.0 3.5 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.1 CDF87851.1 - 0.025 13.9 0.0 4.7 6.7 0.0 3.4 3 0 0 3 3 3 0 EF hand CDK2AP PF09806.4 CDF87851.1 - 0.026 14.7 3.9 0.11 12.7 2.7 1.9 1 1 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein zf-C4H2 PF10146.4 CDF87851.1 - 5.5 6.9 6.8 8.4 6.3 4.7 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein Septin PF00735.13 CDF87852.1 - 1.3e-91 306.5 0.1 2.2e-91 305.7 0.0 1.4 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 CDF87852.1 - 3.7e-05 23.6 0.0 0.0001 22.2 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 CDF87852.1 - 0.00011 21.4 0.0 0.00031 19.9 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_10 PF12846.2 CDF87852.1 - 0.00075 19.0 0.0 0.0014 18.1 0.0 1.5 1 0 0 1 1 1 1 AAA-like domain GTP_EFTU PF00009.22 CDF87852.1 - 0.0047 16.3 0.3 2.7 7.4 0.0 2.8 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain FtsK_SpoIIIE PF01580.13 CDF87852.1 - 0.0055 16.2 0.0 0.014 14.9 0.0 1.6 2 0 0 2 2 2 1 FtsK/SpoIIIE family AIG1 PF04548.11 CDF87852.1 - 0.009 15.1 0.0 0.009 15.1 0.0 2.4 3 0 0 3 3 3 1 AIG1 family Dynamin_N PF00350.18 CDF87852.1 - 0.1 12.4 2.6 3.9 7.2 0.0 3.7 4 0 0 4 4 4 0 Dynamin family AAA_33 PF13671.1 CDF87852.1 - 0.11 12.4 0.1 4.3 7.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.22 CDF87852.1 - 1.9 8.7 9.7 2.3 8.5 0.1 3.4 3 2 0 3 3 3 0 ABC transporter PIN_4 PF13638.1 CDF87853.1 - 0.00018 21.6 0.0 0.00035 20.6 0.0 1.5 1 1 0 1 1 1 1 PIN domain FA_hydroxylase PF04116.8 CDF87854.1 - 3.4e-16 59.6 19.0 3.4e-16 59.6 13.1 2.3 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily TcpE PF12648.2 CDF87854.1 - 1.7 8.7 6.2 0.65 10.1 0.3 2.8 3 0 0 3 3 3 0 TcpE family GATase_5 PF13507.1 CDF87855.1 - 3.4e-97 324.4 0.0 5.8e-97 323.6 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.17 CDF87855.1 - 4.1e-45 153.5 0.3 3.7e-25 88.7 0.0 2.4 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain AIRS PF00586.19 CDF87855.1 - 4e-22 78.2 0.0 1.8e-21 76.2 0.0 2.2 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain DUF2462 PF09495.5 CDF87856.1 - 3.4e-19 69.3 7.5 3.4e-19 69.3 5.2 1.5 1 1 1 2 2 2 1 Protein of unknown function (DUF2462) 60KD_IMP PF02096.15 CDF87857.1 - 1.3e-14 54.3 16.4 3.6e-13 49.6 11.4 2.0 1 1 0 1 1 1 1 60Kd inner membrane protein Glutaredoxin PF00462.19 CDF87858.1 - 1e-06 28.6 0.0 2e-06 27.6 0.0 1.5 1 1 0 1 1 1 1 Glutaredoxin Thioredoxin_9 PF14595.1 CDF87858.1 - 0.0027 17.2 0.0 0.003 17.1 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin PF00085.15 CDF87858.1 - 0.013 15.1 0.1 0.017 14.7 0.1 1.3 1 1 0 1 1 1 0 Thioredoxin Methyltransf_22 PF13383.1 CDF87858.1 - 0.015 14.8 0.0 0.017 14.6 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain DUF953 PF06110.6 CDF87858.1 - 0.02 14.3 0.2 0.024 14.0 0.1 1.3 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) GST_N_2 PF13409.1 CDF87858.1 - 0.11 12.5 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain MFS_1 PF07690.11 CDF87859.1 - 4.1e-22 78.3 12.9 1.6e-20 73.1 8.4 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily 7TMR-DISM_7TM PF07695.6 CDF87859.1 - 6.9 6.2 18.5 0.23 11.1 7.5 2.4 2 1 0 2 2 2 0 7TM diverse intracellular signalling Ribosomal_S8 PF00410.14 CDF87860.1 - 2.3e-26 92.1 0.0 3.1e-26 91.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 zf-C2H2 PF00096.21 CDF87862.1 - 4e-07 29.9 21.1 1.1e-05 25.4 1.3 4.0 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CDF87862.1 - 0.00013 22.0 3.0 0.00013 22.0 2.1 3.5 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 CDF87862.1 - 0.00029 20.9 0.3 0.00029 20.9 0.2 3.7 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2HC_2 PF13913.1 CDF87862.1 - 0.13 11.9 0.9 1.1 8.9 0.4 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.3 CDF87862.1 - 0.91 9.7 6.3 0.51 10.5 0.1 3.1 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CDF87862.1 - 2 8.7 5.4 1.8 8.8 0.2 3.3 3 0 0 3 3 3 0 Zinc-finger of C2H2 type HNH PF01844.18 CDF87862.1 - 4.6 7.2 7.8 2.2 8.2 1.4 2.5 2 0 0 2 2 2 0 HNH endonuclease AAA PF00004.24 CDF87863.1 - 1.3e-92 306.8 0.0 6.8e-47 158.9 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 CDF87863.1 - 1.1e-14 54.1 0.0 1e-07 31.2 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 CDF87863.1 - 7.1e-12 45.6 0.4 0.00025 21.1 0.0 3.5 2 2 0 2 2 2 2 AAA ATPase domain AAA_17 PF13207.1 CDF87863.1 - 9.9e-12 45.7 0.0 1.1e-06 29.4 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 CDF87863.1 - 6.6e-11 42.4 0.1 0.0057 16.8 0.0 5.0 2 2 1 3 3 3 2 AAA domain Zeta_toxin PF06414.7 CDF87863.1 - 3.4e-10 39.3 0.0 0.00071 18.7 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin AAA_33 PF13671.1 CDF87863.1 - 5.4e-10 39.3 0.0 0.00022 21.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.9 CDF87863.1 - 8.3e-10 38.8 0.0 0.00036 20.4 0.0 2.8 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_14 PF13173.1 CDF87863.1 - 1.1e-09 38.2 0.0 0.0025 17.6 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.9 CDF87863.1 - 4.2e-09 36.2 0.2 0.0085 15.8 0.0 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 CDF87863.1 - 4.8e-09 36.6 0.2 8.8e-05 22.8 0.0 3.2 3 0 0 3 3 2 2 AAA domain TIP49 PF06068.8 CDF87863.1 - 1.1e-08 34.2 0.0 0.00038 19.2 0.0 2.5 2 0 0 2 2 2 2 TIP49 C-terminus RNA_helicase PF00910.17 CDF87863.1 - 2.8e-07 30.6 0.0 0.019 15.1 0.0 2.8 2 0 0 2 2 2 2 RNA helicase Vps4_C PF09336.5 CDF87863.1 - 3.2e-07 30.1 0.1 8.7e-05 22.3 0.0 3.0 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain ABC_tran PF00005.22 CDF87863.1 - 3.5e-07 30.6 0.0 0.016 15.4 0.0 3.0 2 0 0 2 2 2 2 ABC transporter AAA_19 PF13245.1 CDF87863.1 - 6.7e-07 28.9 0.5 0.058 13.1 0.1 2.9 2 0 0 2 2 2 2 Part of AAA domain IstB_IS21 PF01695.12 CDF87863.1 - 7.4e-07 28.7 0.3 0.022 14.1 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_28 PF13521.1 CDF87863.1 - 1.5e-06 28.3 0.0 0.03 14.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.16 CDF87863.1 - 3.6e-06 26.2 0.4 0.042 13.0 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 CDF87863.1 - 1.5e-05 24.4 3.0 0.62 9.4 0.0 4.2 2 2 2 4 4 4 1 AAA domain NACHT PF05729.7 CDF87863.1 - 1.9e-05 24.3 0.0 0.49 10.0 0.0 3.4 3 0 0 3 3 3 2 NACHT domain AAA_3 PF07726.6 CDF87863.1 - 2.1e-05 24.1 0.0 0.21 11.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) SKI PF01202.17 CDF87863.1 - 2.1e-05 24.4 2.0 0.072 12.9 0.0 3.7 4 1 0 4 4 2 2 Shikimate kinase Cytidylate_kin2 PF13189.1 CDF87863.1 - 2.5e-05 24.2 0.0 0.0023 17.8 0.0 2.8 2 0 0 2 2 2 1 Cytidylate kinase-like family Rad17 PF03215.10 CDF87863.1 - 0.00011 21.0 0.0 0.063 11.9 0.0 2.8 3 0 0 3 3 3 1 Rad17 cell cycle checkpoint protein SRPRB PF09439.5 CDF87863.1 - 0.00019 20.7 0.0 2.1 7.5 0.0 3.8 3 1 0 3 3 3 1 Signal recognition particle receptor beta subunit Sigma54_activ_2 PF14532.1 CDF87863.1 - 0.00023 21.2 0.0 0.67 10.0 0.0 2.7 2 0 0 2 2 2 2 Sigma-54 interaction domain Arch_ATPase PF01637.13 CDF87863.1 - 0.00024 20.9 0.1 2.1 7.9 0.0 3.5 3 1 1 4 4 3 2 Archaeal ATPase DUF815 PF05673.8 CDF87863.1 - 0.00026 20.0 0.1 0.13 11.1 0.0 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF815) NB-ARC PF00931.17 CDF87863.1 - 0.00026 19.9 0.4 0.31 9.8 0.0 3.2 4 0 0 4 4 3 1 NB-ARC domain Viral_helicase1 PF01443.13 CDF87863.1 - 0.00026 20.5 0.0 0.82 9.1 0.0 2.4 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.21 CDF87863.1 - 0.00027 20.4 0.0 0.23 10.9 0.0 3.0 3 0 0 3 3 3 1 Sigma-54 interaction domain CPT PF07931.7 CDF87863.1 - 0.00098 18.7 0.0 0.023 14.3 0.0 2.4 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein AAA_11 PF13086.1 CDF87863.1 - 0.001 18.7 0.6 0.98 8.9 0.0 3.4 3 0 0 3 3 3 1 AAA domain Parvo_NS1 PF01057.12 CDF87863.1 - 0.0023 16.8 0.0 1.6 7.5 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_24 PF13479.1 CDF87863.1 - 0.0025 17.4 0.0 2.3 7.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain KaiC PF06745.8 CDF87863.1 - 0.0027 16.8 0.1 1.4 7.9 0.0 3.1 3 0 0 3 3 3 1 KaiC PhoH PF02562.11 CDF87863.1 - 0.0054 15.9 0.1 1.6 7.9 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein ATP-synt_ab PF00006.20 CDF87863.1 - 0.0069 15.8 0.0 1.8 8.0 0.0 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain IPT PF01745.11 CDF87863.1 - 0.01 15.0 0.4 10 5.2 0.0 3.1 3 0 0 3 3 3 0 Isopentenyl transferase NTPase_1 PF03266.10 CDF87863.1 - 0.017 14.8 0.2 4.1 7.0 0.0 2.9 3 0 0 3 3 2 0 NTPase PduV-EutP PF10662.4 CDF87863.1 - 0.019 14.4 0.0 6.7 6.1 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AFG1_ATPase PF03969.11 CDF87863.1 - 0.021 13.6 0.3 8.8 5.0 0.1 3.3 3 1 0 3 3 3 0 AFG1-like ATPase UPF0079 PF02367.12 CDF87863.1 - 0.023 14.3 0.0 9.2 5.9 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 ResIII PF04851.10 CDF87863.1 - 0.056 13.2 0.0 5.3 6.8 0.0 2.9 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit MMR_HSR1 PF01926.18 CDF87863.1 - 0.063 13.2 0.0 3 7.8 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase FeoB_N PF02421.13 CDF87863.1 - 0.069 12.4 0.1 2.2 7.5 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF258 PF03193.11 CDF87863.1 - 0.11 11.7 0.1 1.6 7.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 CDF87863.1 - 0.12 11.9 0.0 6.2 6.4 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.1 CDF87863.1 - 1.9 8.7 8.6 2.1 8.5 0.0 3.9 4 0 0 4 4 3 0 AAA domain DUF2456 PF10445.4 CDF87864.1 - 2.4e-25 88.2 1.6 4.1e-25 87.5 1.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2456) Spc7 PF08317.6 CDF87865.1 - 1.4e-73 247.4 1.3 1.4e-73 247.4 0.9 1.7 2 0 0 2 2 2 1 Spc7 kinetochore protein Spc7_N PF15402.1 CDF87865.1 - 0.00044 18.4 3.1 0.00044 18.4 2.2 2.3 2 1 1 3 3 3 1 N-terminus of kinetochore NMS complex subunit Spc7 PMT_2 PF13231.1 CDF87865.1 - 0.15 11.9 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 Dolichyl-phosphate-mannose-protein mannosyltransferase ParA PF10609.4 CDF87867.1 - 2.4e-36 123.4 0.0 1e-35 121.4 0.0 2.0 2 0 0 2 2 2 1 ParA/MinD ATPase like CbiA PF01656.18 CDF87867.1 - 9.2e-17 61.0 0.0 1.9e-16 60.0 0.0 1.5 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 CDF87867.1 - 5.6e-06 26.3 0.0 2.6e-05 24.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain MipZ PF09140.6 CDF87867.1 - 1.1e-05 24.6 0.0 1.7e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.10 CDF87867.1 - 4.6e-05 22.6 0.3 0.0025 16.9 0.0 2.4 2 1 0 2 2 2 1 Anion-transporting ATPase DUF258 PF03193.11 CDF87867.1 - 0.0033 16.6 0.0 0.0068 15.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_25 PF13481.1 CDF87867.1 - 0.0047 16.3 0.0 0.009 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain YhjQ PF06564.7 CDF87867.1 - 0.13 11.5 0.3 0.24 10.7 0.1 1.5 1 1 0 1 1 1 0 YhjQ protein NB-ARC PF00931.17 CDF87867.1 - 0.15 10.8 0.0 0.22 10.3 0.0 1.1 1 0 0 1 1 1 0 NB-ARC domain XLF PF09302.6 CDF87868.1 - 4.3e-11 42.8 2.3 8.9e-11 41.8 1.6 1.6 1 1 0 1 1 1 1 XLF (XRCC4-like factor) Hrs_helical PF12210.3 CDF87868.1 - 0.0019 18.4 0.9 0.0034 17.6 0.6 1.4 1 0 0 1 1 1 1 Hepatocyte growth factor-regulated tyrosine kinase substrate MerR-DNA-bind PF09278.6 CDF87868.1 - 0.035 14.5 1.1 0.097 13.0 0.8 1.8 1 0 0 1 1 1 0 MerR, DNA binding Atg14 PF10186.4 CDF87868.1 - 0.042 12.8 2.3 0.065 12.1 1.4 1.6 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DUF342 PF03961.8 CDF87868.1 - 0.064 11.6 0.9 0.085 11.2 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) V_ATPase_I PF01496.14 CDF87868.1 - 0.11 10.3 1.0 0.14 9.9 0.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc24 PF08286.6 CDF87868.1 - 0.11 12.1 2.0 0.28 10.8 1.4 1.6 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DivIC PF04977.10 CDF87868.1 - 0.12 11.9 2.4 0.25 10.8 1.7 1.5 1 0 0 1 1 1 0 Septum formation initiator DUF3745 PF12560.3 CDF87868.1 - 0.14 11.8 0.3 1.2 8.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3745) DUF3186 PF11382.3 CDF87868.1 - 0.24 10.4 2.7 0.37 9.8 1.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3186) IncA PF04156.9 CDF87868.1 - 7.6 6.0 10.5 0.091 12.3 1.9 1.7 2 0 0 2 2 2 0 IncA protein RRM_1 PF00076.17 CDF87869.1 - 7.2e-28 96.0 0.3 2.5e-07 30.2 0.0 5.3 5 1 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF87869.1 - 8.5e-28 96.1 0.9 1.2e-06 28.4 0.0 5.8 6 0 0 6 6 6 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF87869.1 - 7.7e-23 80.1 1.9 2.9e-06 27.0 0.1 4.9 4 1 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CDF87869.1 - 0.004 16.8 0.0 3.4 7.5 0.0 2.8 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 CDF87869.1 - 0.031 14.1 0.0 5.9 6.7 0.0 2.8 3 0 0 3 3 3 0 RNA binding motif NAD_kinase PF01513.16 CDF87872.1 - 3.1e-53 180.4 0.0 4.4e-53 179.8 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.19 CDF87872.1 - 0.046 13.1 0.0 0.091 12.1 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain UQ_con PF00179.21 CDF87873.1 - 4.5e-20 71.5 0.0 5.1e-20 71.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 CDF87873.1 - 0.00044 20.1 0.0 0.00046 20.0 0.0 1.2 1 0 0 1 1 1 1 RWD domain MAD PF05557.8 CDF87874.1 - 7.5e-24 83.8 81.9 1.1e-22 80.0 56.8 1.9 1 1 0 1 1 1 1 Mitotic checkpoint protein Tropomyosin_1 PF12718.2 CDF87874.1 - 0.011 15.6 19.3 0.011 15.6 13.4 5.6 3 2 3 6 6 6 0 Tropomyosin like SNase PF00565.12 CDF87875.1 - 4.9e-26 91.1 0.1 7.3e-26 90.5 0.1 1.3 1 0 0 1 1 1 1 Staphylococcal nuclease homologue MBOAT PF03062.14 CDF87876.1 - 1.5e-55 188.6 17.8 2.6e-55 187.8 12.4 1.4 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Pkinase PF00069.20 CDF87877.1 - 2.2e-20 72.8 0.0 3.9e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF87877.1 - 1.8e-13 50.1 0.0 3.2e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF544 PF04424.8 CDF87880.1 - 1.2e-28 99.3 0.0 2e-28 98.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF544) FHA PF00498.21 CDF87881.1 - 3.9e-05 23.6 0.0 9.8e-05 22.4 0.0 1.7 1 1 1 2 2 2 1 FHA domain YjzC PF14168.1 CDF87881.1 - 0.054 13.4 0.3 2.3 8.2 0.1 2.6 3 0 0 3 3 3 0 YjzC-like protein UPF1_Zn_bind PF09416.5 CDF87881.1 - 0.13 11.8 0.8 0.28 10.7 0.5 1.6 1 1 0 1 1 1 0 RNA helicase (UPF2 interacting domain) CPSF73-100_C PF11718.3 CDF87881.1 - 1.2 8.4 5.6 1.8 7.8 3.9 1.3 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term MPC PF03650.8 CDF87883.1 - 7.9e-42 141.9 0.2 9.5e-42 141.7 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) Rad9 PF04139.8 CDF87884.1 - 1.3e-09 37.6 0.4 0.00011 21.3 0.1 2.3 2 0 0 2 2 2 2 Rad9 DUF1456 PF07308.8 CDF87884.1 - 1.5 8.9 8.0 2.1 8.4 0.1 4.1 5 1 0 5 5 5 0 Protein of unknown function (DUF1456) Adaptin_N PF01602.15 CDF87885.1 - 7.7e-114 380.8 11.1 9.8e-114 380.5 7.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 CDF87885.1 - 1e-11 45.0 5.6 2.3e-10 40.6 0.2 3.6 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 CDF87885.1 - 1.9e-07 31.2 0.8 0.079 13.2 0.0 5.2 3 1 3 6 6 6 4 HEAT repeats HEAT PF02985.17 CDF87885.1 - 2e-07 30.5 2.2 3.4 7.9 0.1 6.4 7 0 0 7 7 7 2 HEAT repeat Viral_P18 PF04521.8 CDF87885.1 - 0.02 14.3 3.5 0.046 13.1 2.5 1.6 1 0 0 1 1 1 0 ssRNA positive strand viral 18kD cysteine rich protein DUF1678 PF07913.6 CDF87885.1 - 0.12 11.8 0.2 2.5 7.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1678) KxDL PF10241.4 CDF87886.1 - 4.8e-08 32.7 0.8 8e-08 32.0 0.6 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein SHOCT PF09851.4 CDF87886.1 - 0.037 13.5 3.1 0.22 11.0 0.0 3.0 3 0 0 3 3 3 0 Short C-terminal domain TLD PF07534.11 CDF87887.1 - 8.8e-32 109.9 0.1 5.3e-31 107.4 0.0 2.0 1 1 0 1 1 1 1 TLD DEAD PF00270.24 CDF87888.1 - 1.4e-50 171.1 0.1 5.3e-49 165.9 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF87888.1 - 6.5e-30 102.8 0.0 3.1e-28 97.4 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_19 PF13245.1 CDF87888.1 - 0.0013 18.4 0.0 0.0053 16.4 0.0 2.0 1 1 1 2 2 2 1 Part of AAA domain CMS1 PF14617.1 CDF87888.1 - 0.0059 15.7 0.0 0.0059 15.7 0.0 3.1 2 1 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit DUF1253 PF06862.7 CDF87888.1 - 0.02 13.3 0.1 0.02 13.3 0.0 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF1253) AAA_22 PF13401.1 CDF87888.1 - 0.036 14.2 0.4 0.14 12.3 0.2 2.2 1 1 0 1 1 1 0 AAA domain AA_permease_2 PF13520.1 CDF87889.1 - 2.7e-50 171.1 49.4 3.3e-50 170.8 34.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CDF87889.1 - 9.5e-27 93.4 40.2 1.2e-26 93.0 27.9 1.0 1 0 0 1 1 1 1 Amino acid permease Ribosomal_L30_N PF08079.7 CDF87890.1 - 5.9e-19 67.8 17.1 1.2e-18 66.8 11.9 1.6 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.15 CDF87890.1 - 6.9e-18 63.9 0.8 1.3e-17 63.1 0.6 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e CDK5_activator PF03261.10 CDF87890.1 - 0.075 12.3 1.0 0.1 11.9 0.7 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein DUF1771 PF08590.5 CDF87891.1 - 1.5e-20 72.9 11.7 1.5e-20 72.9 8.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) Smr PF01713.16 CDF87891.1 - 3.2e-15 56.0 1.4 7.3e-15 54.9 0.0 2.1 2 0 0 2 2 2 1 Smr domain DUF912 PF06024.7 CDF87891.1 - 0.002 18.1 1.3 0.002 18.1 0.9 2.1 2 0 0 2 2 2 1 Nucleopolyhedrovirus protein of unknown function (DUF912) cwf18 PF08315.7 CDF87891.1 - 0.025 15.0 4.1 0.025 15.0 2.8 2.3 2 0 0 2 2 2 0 cwf18 pre-mRNA splicing factor PalH PF08733.5 CDF87891.1 - 0.23 10.2 1.2 0.34 9.7 0.9 1.2 1 0 0 1 1 1 0 PalH/RIM21 CD20 PF04103.10 CDF87891.1 - 1.9 8.4 4.1 3.9 7.3 2.9 1.5 1 0 0 1 1 1 0 CD20-like family PRCC PF10253.4 CDF87891.1 - 6.3 7.4 25.1 4.3 7.9 8.0 3.0 2 1 1 3 3 3 0 Mitotic checkpoint regulator, MAD2B-interacting TFIIA PF03153.8 CDF87891.1 - 7.3 6.3 22.0 9.2 6.0 11.1 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Spatacsin_C PF14649.1 CDF87892.1 - 0.0029 16.5 0.8 0.0046 15.8 0.6 1.2 1 0 0 1 1 1 1 Spatacsin C-terminus SlyX PF04102.7 CDF87892.1 - 0.019 15.3 0.5 2.5 8.5 0.0 2.3 2 0 0 2 2 2 0 SlyX FUSC PF04632.7 CDF87892.1 - 0.034 12.5 0.0 0.041 12.3 0.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Tropomyosin_1 PF12718.2 CDF87892.1 - 0.12 12.2 6.2 0.25 11.1 4.3 1.5 1 1 0 1 1 1 0 Tropomyosin like DivIVA PF05103.8 CDF87892.1 - 0.2 11.7 6.7 0.3 11.1 1.1 2.2 1 1 1 2 2 2 0 DivIVA protein DUF3810 PF12725.2 CDF87892.1 - 0.25 10.2 1.9 0.86 8.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) Fib_alpha PF08702.5 CDF87892.1 - 0.67 10.0 5.9 0.34 11.0 1.5 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family SAB PF04382.8 CDF87892.1 - 1 9.0 5.0 0.23 11.2 0.3 2.3 2 0 0 2 2 2 0 SAB domain Ly49 PF08391.5 CDF87892.1 - 2.4 8.2 4.9 3.6 7.7 2.2 2.0 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region DUF641 PF04859.7 CDF87892.1 - 2.5 7.8 8.4 3.3 7.4 1.9 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) HSF_DNA-bind PF00447.12 CDF87893.1 - 3.6e-35 120.2 5.8 7.4e-35 119.2 4.0 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding FBPase PF00316.15 CDF87893.1 - 0.1 11.4 0.0 0.2 10.4 0.0 1.4 1 0 0 1 1 1 0 Fructose-1-6-bisphosphatase Tmemb_cc2 PF10267.4 CDF87893.1 - 0.39 9.2 7.1 0.025 13.1 0.3 2.0 2 1 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein RNA_POL_M_15KD PF02150.11 CDF87896.1 - 2.3e-15 55.9 4.9 2.3e-15 55.9 3.4 2.5 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.13 CDF87896.1 - 3.9e-15 55.2 15.9 9.3e-15 53.9 1.7 3.1 2 1 1 3 3 3 1 Transcription factor S-II (TFIIS) Lar_restr_allev PF14354.1 CDF87896.1 - 0.00065 19.9 2.6 0.0087 16.3 0.2 2.2 2 0 0 2 2 2 1 Restriction alleviation protein Lar Rubredoxin PF00301.15 CDF87896.1 - 0.0068 16.2 3.8 23 4.9 0.0 4.0 4 0 0 4 4 4 0 Rubredoxin DZR PF12773.2 CDF87896.1 - 0.018 14.8 8.0 0.2 11.4 0.4 2.4 2 1 0 2 2 2 0 Double zinc ribbon Zn_Tnp_IS1595 PF12760.2 CDF87896.1 - 0.024 14.4 11.5 0.78 9.5 2.8 3.1 2 1 1 3 3 3 0 Transposase zinc-ribbon domain Cytochrome_C7 PF14522.1 CDF87896.1 - 0.026 14.1 2.2 0.15 11.6 0.1 2.3 2 0 0 2 2 2 0 Cytochrome c7 DUF2387 PF09526.5 CDF87896.1 - 0.032 14.1 3.3 1.4 8.8 0.3 2.4 2 1 0 2 2 2 0 Probable metal-binding protein (DUF2387) zf-UBP PF02148.14 CDF87896.1 - 0.034 14.2 3.5 0.8 9.8 0.2 2.3 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein C1_4 PF07975.7 CDF87896.1 - 0.066 13.2 10.8 0.36 10.8 0.7 3.0 2 1 1 3 3 3 0 TFIIH C1-like domain Cytochrom_NNT PF03264.9 CDF87896.1 - 0.075 12.4 0.5 0.075 12.4 0.4 2.0 2 1 0 2 2 2 0 NapC/NirT cytochrome c family, N-terminal region zf-CHY PF05495.7 CDF87896.1 - 0.096 12.8 6.5 0.42 10.7 0.8 2.3 2 0 0 2 2 2 0 CHY zinc finger PhrC_PhrF PF11131.3 CDF87896.1 - 0.1 12.2 0.3 0.17 11.4 0.2 1.3 1 0 0 1 1 1 0 Rap-phr extracellular signalling Cytochrom_c3_2 PF14537.1 CDF87896.1 - 0.13 12.6 2.2 0.35 11.2 0.2 2.1 2 0 0 2 2 2 0 Cytochrome c3 GFA PF04828.9 CDF87896.1 - 0.37 10.7 4.9 5.5 7.0 0.7 2.5 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme IBR PF01485.16 CDF87896.1 - 0.4 10.5 7.1 1.3 9.0 0.4 2.7 2 1 0 2 2 2 0 IBR domain zf-ribbon_3 PF13248.1 CDF87896.1 - 1.2 8.3 8.2 12 5.2 0.1 3.6 4 0 0 4 4 4 0 zinc-ribbon domain DUF2296 PF10058.4 CDF87896.1 - 1.7 8.4 7.0 1.6 8.5 0.3 2.5 2 1 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) zf-CSL PF05207.8 CDF87896.1 - 1.8 8.1 5.0 3.6 7.1 0.2 2.3 2 0 0 2 2 2 0 CSL zinc finger Mut7-C PF01927.11 CDF87896.1 - 3.4 7.6 5.9 2 8.3 0.4 2.3 1 1 1 2 2 2 0 Mut7-C RNAse domain RPA_interact_C PF14768.1 CDF87896.1 - 5.3 7.5 10.4 2.6 8.5 0.8 2.5 2 2 0 2 2 2 0 Replication protein A interacting C-terminal Zn-ribbon_8 PF09723.5 CDF87896.1 - 5.7 6.9 13.6 4.4 7.3 0.0 3.9 3 1 1 4 4 4 0 Zinc ribbon domain HypA PF01155.14 CDF87896.1 - 6.2 6.5 8.6 24 4.6 3.5 2.9 1 1 0 2 2 2 0 Hydrogenase expression/synthesis hypA family zf-RING_5 PF14634.1 CDF87896.1 - 6.2 6.6 13.0 0.23 11.2 2.3 2.5 2 2 0 2 2 2 0 zinc-RING finger domain Rpr2 PF04032.11 CDF87896.1 - 8.5 6.3 9.1 4.9e+02 0.6 6.3 2.6 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Ribosomal_L12 PF00542.14 CDF87897.1 - 9.8e-19 67.1 6.0 9.8e-19 67.1 4.1 2.1 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_60s PF00428.14 CDF87897.1 - 0.011 16.0 5.8 0.011 16.0 4.0 2.3 1 1 1 2 2 2 0 60s Acidic ribosomal protein BID PF06393.6 CDF87897.1 - 0.14 11.4 0.4 0.4 9.9 0.1 1.8 2 0 0 2 2 2 0 BH3 interacting domain (BID) Pkinase PF00069.20 CDF87898.1 - 8.2e-70 234.9 0.0 9.6e-70 234.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF87898.1 - 3.9e-39 134.2 0.0 5e-39 133.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF87898.1 - 0.00014 20.8 0.0 0.00027 19.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like WaaY PF06176.6 CDF87898.1 - 0.0077 15.4 0.3 0.013 14.7 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) YrbL-PhoP_reg PF10707.4 CDF87898.1 - 0.036 13.4 0.0 0.1 11.9 0.0 1.8 2 1 0 2 2 2 0 PhoP regulatory network protein YrbL APH PF01636.18 CDF87898.1 - 0.049 13.3 0.0 0.11 12.2 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 CDF87898.1 - 0.09 11.8 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.6 CDF87898.1 - 0.093 11.5 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase PF00069.20 CDF87899.1 - 3.9e-41 140.9 0.0 7e-41 140.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF87899.1 - 7.7e-16 57.9 0.0 1.2e-15 57.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CDF87899.1 - 0.017 14.8 0.2 0.084 12.5 0.0 2.2 3 0 0 3 3 3 0 Phosphotransferase enzyme family Kinase-like PF14531.1 CDF87899.1 - 0.12 11.3 0.0 0.29 10.0 0.0 1.8 2 0 0 2 2 2 0 Kinase-like NUDIX PF00293.23 CDF87901.1 - 5.7e-14 51.9 0.0 1.1e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain zf-NADH-PPase PF09297.6 CDF87901.1 - 1.5e-05 24.3 0.0 3.1e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain NUDIX-like PF09296.6 CDF87901.1 - 0.023 15.0 0.0 0.037 14.3 0.0 1.4 1 0 0 1 1 1 0 NADH pyrophosphatase-like rudimentary NUDIX domain DUF3323 PF11796.3 CDF87901.1 - 0.12 11.7 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) RNA_POL_M_15KD PF02150.11 CDF87901.1 - 0.26 10.9 1.7 1.4 8.6 0.5 2.2 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit GDPD PF03009.12 CDF87902.1 - 4.6e-29 101.6 0.7 2.8e-28 99.1 0.5 1.9 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.1 CDF87902.1 - 0.0035 17.4 0.4 0.018 15.2 0.1 2.3 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family SCA7 PF08313.7 CDF87903.1 - 2.5e-33 113.5 2.2 2.5e-33 113.5 1.5 2.1 2 0 0 2 2 2 1 SCA7, zinc-binding domain Glycos_transf_1 PF00534.15 CDF87904.1 - 5.9e-37 126.7 0.1 1e-36 125.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 CDF87904.1 - 2.5e-08 33.8 0.0 1.8e-07 31.0 0.0 2.1 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.1 CDF87904.1 - 1.4e-07 31.7 0.0 7.3e-06 26.1 0.0 2.6 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 CDF87904.1 - 7e-05 23.0 0.0 0.00011 22.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain DUF1992 PF09350.5 CDF87905.1 - 2.1e-19 69.0 0.1 7e-19 67.4 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1992) Wyosine_form PF08608.7 CDF87906.1 - 3.4e-21 75.1 0.0 7.6e-21 73.9 0.0 1.6 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.16 CDF87906.1 - 2.6e-20 73.2 0.0 7e-20 71.8 0.0 1.8 1 0 0 1 1 1 1 Radical SAM superfamily Flavodoxin_1 PF00258.20 CDF87906.1 - 5.1e-12 45.9 0.0 1.3e-11 44.6 0.0 1.8 1 0 0 1 1 1 1 Flavodoxin ATP-synt_A PF00119.15 CDF87906.1 - 0.044 13.2 2.9 0.12 11.8 1.5 1.8 2 0 0 2 2 2 0 ATP synthase A chain DUF4264 PF14084.1 CDF87906.1 - 0.11 11.8 0.1 15 5.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4264) SET PF00856.23 CDF87907.1 - 0.012 15.9 0.1 0.027 14.7 0.0 1.6 1 0 0 1 1 1 0 SET domain KA1 PF02149.14 CDF87908.1 - 0.097 12.1 0.1 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Kinase associated domain 1 Coprogen_oxidas PF01218.13 CDF87911.1 - 7.6e-134 444.8 0.2 8.7e-134 444.7 0.1 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase TFIIS_C PF01096.13 CDF87912.1 - 8.3e-22 76.5 1.7 8.3e-22 76.5 1.2 2.8 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.11 CDF87912.1 - 3.9e-13 48.8 3.1 6.1e-13 48.2 0.2 2.3 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.2 CDF87912.1 - 0.006 16.3 4.8 0.73 9.6 0.5 2.8 2 1 0 2 2 2 2 Transposase zinc-ribbon domain Elf1 PF05129.8 CDF87912.1 - 0.029 14.0 4.3 0.45 10.2 0.1 2.4 2 1 0 2 2 2 0 Transcription elongation factor Elf1 like Terminase_GpA PF05876.7 CDF87912.1 - 0.03 12.6 0.4 0.46 8.7 0.3 2.0 1 1 0 1 1 1 0 Phage terminase large subunit (GpA) PhnA_Zn_Ribbon PF08274.7 CDF87912.1 - 0.031 14.0 6.4 0.46 10.3 0.1 3.2 3 0 0 3 3 3 0 PhnA Zinc-Ribbon DUF2387 PF09526.5 CDF87912.1 - 0.048 13.5 2.3 1.9 8.4 0.1 2.3 2 1 0 2 2 2 0 Probable metal-binding protein (DUF2387) zf-piccolo PF05715.8 CDF87912.1 - 0.08 12.9 0.5 0.08 12.9 0.4 2.3 3 0 0 3 3 3 0 Piccolo Zn-finger zinc_ribbon_5 PF13719.1 CDF87912.1 - 0.29 10.7 9.5 7.4 6.2 0.3 3.8 3 1 0 3 3 3 0 zinc-ribbon domain DZR PF12773.2 CDF87912.1 - 0.38 10.6 4.7 2.6 7.9 0.1 2.7 2 1 0 2 2 2 0 Double zinc ribbon IBR PF01485.16 CDF87912.1 - 0.55 10.1 7.4 1.5 8.7 0.1 3.0 2 1 1 3 3 3 0 IBR domain Baculo_LEF5_C PF11792.3 CDF87912.1 - 0.99 8.8 3.5 0.91 8.9 0.1 2.5 3 0 0 3 3 3 0 Baculoviridae late expression factor 5 C-terminal domain Lar_restr_allev PF14354.1 CDF87912.1 - 1.5 9.2 6.7 8 6.8 0.2 2.6 1 1 1 2 2 2 0 Restriction alleviation protein Lar Trs65 PF12735.2 CDF87913.1 - 3.3e-48 164.5 0.7 5.4e-48 163.8 0.5 1.3 1 0 0 1 1 1 1 TRAPP trafficking subunit Trs65 Clathrin_lg_ch PF01086.12 CDF87914.1 - 2.8e-39 135.3 10.2 3.3e-39 135.1 7.1 1.0 1 0 0 1 1 1 1 Clathrin light chain IFRD PF05004.8 CDF87914.1 - 0.017 14.2 0.8 0.021 13.9 0.5 1.1 1 0 0 1 1 1 0 Interferon-related developmental regulator (IFRD) DUF3510 PF12022.3 CDF87914.1 - 0.072 13.1 1.9 0.1 12.7 1.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3510) DUF4065 PF13274.1 CDF87914.1 - 0.1 13.3 3.9 0.15 12.7 2.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4065) 7TMR-HDED PF07697.6 CDF87914.1 - 0.12 12.0 7.4 0.15 11.8 5.1 1.1 1 0 0 1 1 1 0 7TM-HD extracellular Ferritin-like PF12902.2 CDF87914.1 - 0.12 11.9 1.1 0.14 11.7 0.8 1.1 1 0 0 1 1 1 0 Ferritin-like DDRGK PF09756.4 CDF87914.1 - 0.24 10.7 10.6 0.28 10.5 7.3 1.2 1 0 0 1 1 1 0 DDRGK domain DUF4111 PF13427.1 CDF87914.1 - 0.39 10.5 2.6 0.65 9.8 1.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4111) SPX PF03105.14 CDF87914.1 - 0.43 10.3 6.3 0.48 10.1 4.4 1.1 1 0 0 1 1 1 0 SPX domain HlyD_2 PF12700.2 CDF87914.1 - 0.71 8.9 5.8 0.79 8.8 4.0 1.1 1 0 0 1 1 1 0 HlyD family secretion protein LMBR1 PF04791.11 CDF87914.1 - 0.73 8.3 2.7 0.75 8.3 1.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Osmo_CC PF08946.5 CDF87914.1 - 1.2 9.1 7.8 27 4.8 3.2 3.2 3 1 0 3 3 3 0 Osmosensory transporter coiled coil DUF4337 PF14235.1 CDF87914.1 - 2.8 7.7 6.5 4.2 7.2 4.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) SH3_1 PF00018.23 CDF87916.1 - 1.8e-08 33.5 0.2 1.8e-08 33.5 0.1 2.5 3 0 0 3 3 3 1 SH3 domain SH3_9 PF14604.1 CDF87916.1 - 2.2e-07 30.3 0.1 8.6e-07 28.4 0.1 2.1 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 CDF87916.1 - 9.5e-06 25.0 0.0 1.9e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain IncA PF04156.9 CDF87916.1 - 5.2 6.6 12.9 0.079 12.5 3.5 1.8 2 0 0 2 2 2 0 IncA protein PseudoU_synth_2 PF00849.17 CDF87917.1 - 1.1e-24 87.1 0.0 2e-24 86.3 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase zf-ribbon_3 PF13248.1 CDF87917.1 - 0.087 12.0 0.3 0.19 10.9 0.2 1.6 1 1 0 1 1 1 0 zinc-ribbon domain Gly_radical PF01228.16 CDF87919.1 - 0.29 11.4 2.2 0.36 11.2 1.3 1.3 1 1 0 1 1 1 0 Glycine radical DUF1501 PF07394.7 CDF87919.1 - 0.91 8.2 4.4 0.89 8.3 3.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) DUF3523 PF12037.3 CDF87919.1 - 1.7 7.5 26.7 1.8 7.4 18.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) BTV_NS2 PF04514.7 CDF87919.1 - 6 5.6 17.6 6.6 5.5 12.2 1.0 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 CAF-1_p150 PF11600.3 CDF87919.1 - 7.2 5.9 41.4 8.3 5.7 28.7 1.0 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Bud13 PF09736.4 CDF87919.1 - 7.8 6.7 24.5 12 6.1 17.0 1.3 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex AATF-Che1 PF13339.1 CDF87920.1 - 5.8e-28 97.6 6.1 5.8e-28 97.6 4.3 2.5 2 1 0 2 2 2 1 Apoptosis antagonizing transcription factor TRAUB PF08164.7 CDF87920.1 - 1.6e-27 95.3 2.8 3.7e-27 94.2 0.1 2.8 2 0 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal GOLD_2 PF13897.1 CDF87920.1 - 2.2 8.5 8.0 0.57 10.4 2.4 2.4 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking PIH1 PF08190.7 CDF87921.1 - 3e-24 86.0 3.5 7.2e-24 84.8 2.4 1.5 1 1 0 1 1 1 1 pre-RNA processing PIH1/Nop17 AA_kinase PF00696.23 CDF87922.1 - 1e-36 126.7 0.2 1.4e-36 126.2 0.1 1.2 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.15 CDF87922.1 - 1.9e-19 69.1 0.0 3.9e-19 68.1 0.0 1.6 1 0 0 1 1 1 1 PUA domain CPSF_A PF03178.10 CDF87923.1 - 4.1e-84 282.4 0.7 9.9e-84 281.1 0.1 2.0 2 0 0 2 2 2 1 CPSF A subunit region PIG-F PF06699.6 CDF87924.1 - 1.5e-40 139.1 22.8 8.6e-40 136.7 15.8 1.8 1 1 0 1 1 1 1 GPI biosynthesis protein family Pig-F AIM24 PF01987.12 CDF87925.1 - 7.3e-13 48.4 0.0 2.3e-12 46.8 0.0 1.8 1 1 0 1 1 1 1 Mitochondrial biogenesis AIM24 Zn_clus PF00172.13 CDF87926.1 - 3.2e-09 36.5 8.2 5.6e-09 35.7 5.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1319 PF07028.6 CDF87926.1 - 0.019 15.1 3.3 0.18 11.9 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1319) TRH PF05438.7 CDF87926.1 - 0.11 11.8 0.5 0.29 10.4 0.0 1.8 2 0 0 2 2 2 0 Thyrotropin-releasing hormone (TRH) Pro_isomerase PF00160.16 CDF87927.1 - 1.3e-44 152.1 0.4 1.6e-44 151.8 0.3 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Thioredoxin_3 PF13192.1 CDF87927.1 - 0.13 12.1 0.0 0.37 10.6 0.0 1.7 2 0 0 2 2 2 0 Thioredoxin domain Med6 PF04934.9 CDF87928.1 - 2.1e-55 186.1 0.1 3e-55 185.6 0.0 1.2 1 0 0 1 1 1 1 MED6 mediator sub complex component IGR PF09597.5 CDF87929.1 - 1.8e-23 82.1 0.2 3.2e-23 81.4 0.1 1.4 1 0 0 1 1 1 1 IGR protein motif HIT PF01230.18 CDF87930.1 - 3.1e-25 88.5 0.4 4.9e-25 87.9 0.3 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 CDF87930.1 - 1.5e-06 28.3 0.3 2.3e-06 27.8 0.2 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.10 CDF87930.1 - 0.057 13.0 0.3 0.12 12.0 0.2 1.5 1 1 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 LRR_8 PF13855.1 CDF87931.1 - 0.014 15.1 1.8 8.2 6.2 0.2 4.2 3 2 0 3 3 3 0 Leucine rich repeat MIR PF02815.14 CDF87932.1 - 9.7e-17 61.1 0.0 1.9e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 MIR domain PMT PF02366.13 CDF87932.1 - 8.8e-10 38.3 18.4 8.8e-10 38.3 12.8 2.0 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Med21 PF11221.3 CDF87933.1 - 5.4e-48 162.6 2.1 6.3e-48 162.4 1.5 1.1 1 0 0 1 1 1 1 Subunit 21 of Mediator complex TMCO5 PF14992.1 CDF87933.1 - 0.0014 17.8 3.6 0.0014 17.7 2.5 1.2 1 0 0 1 1 1 1 TMCO5 family Med9 PF07544.8 CDF87933.1 - 0.0037 16.9 0.7 0.007 16.0 0.2 1.7 1 1 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Sipho_Gp157 PF05565.6 CDF87933.1 - 0.019 14.5 1.5 0.028 13.9 1.0 1.3 1 0 0 1 1 1 0 Siphovirus Gp157 Katanin_con80 PF13925.1 CDF87933.1 - 0.053 13.2 0.5 0.082 12.6 0.1 1.5 2 0 0 2 2 2 0 con80 domain of Katanin Peptidase_S49 PF01343.13 CDF87933.1 - 0.11 12.3 0.5 0.22 11.3 0.1 1.8 2 0 0 2 2 2 0 Peptidase family S49 DUF1640 PF07798.6 CDF87933.1 - 0.17 11.9 3.6 0.18 11.8 2.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) PBD PF00786.23 CDF87935.1 - 0.0013 19.0 0.3 0.0053 17.1 0.2 2.1 1 0 0 1 1 1 1 P21-Rho-binding domain RNase_P_p30 PF01876.11 CDF87936.1 - 2.8e-51 172.7 0.6 3.9e-51 172.2 0.4 1.2 1 0 0 1 1 1 1 RNase P subunit p30 ApbA PF02558.11 CDF87938.1 - 5.3e-30 103.8 0.0 9e-30 103.1 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.6 CDF87938.1 - 8.8e-29 100.0 0.0 1.4e-28 99.3 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal NAD_binding_2 PF03446.10 CDF87938.1 - 0.043 13.6 0.0 0.097 12.5 0.0 1.6 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.18 CDF87938.1 - 0.061 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus HSP70 PF00012.15 CDF87939.1 - 5.9e-74 249.0 3.4 1.6e-73 247.6 0.3 2.1 2 1 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 CDF87939.1 - 1.2e-09 37.2 0.0 1.9e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 MreB/Mbl protein Actin PF00022.14 CDF87939.1 - 0.0028 16.1 0.0 0.0087 14.5 0.0 1.7 2 0 0 2 2 2 1 Actin BSD PF03909.12 CDF87940.1 - 1.2e-25 88.9 1.6 7.2e-14 51.2 0.3 2.6 2 0 0 2 2 2 2 BSD domain TFIIH_BTF_p62_N PF08567.6 CDF87940.1 - 3.4e-22 77.8 0.4 9.3e-22 76.4 0.3 1.8 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain DEAD PF00270.24 CDF87941.1 - 7.8e-48 162.1 0.0 2.4e-47 160.5 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF87941.1 - 1.1e-26 92.4 0.1 3.1e-26 91.0 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDF87941.1 - 8.9e-07 28.9 0.0 8.6e-06 25.7 0.0 2.5 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit ETAA1 PF15350.1 CDF87941.1 - 0.011 13.7 2.7 0.017 13.1 1.9 1.1 1 0 0 1 1 1 0 Ewing's tumour-associated antigen 1 homologue GLTP PF08718.6 CDF87941.1 - 0.14 12.2 0.0 0.14 12.2 0.0 2.0 2 0 0 2 2 2 0 Glycolipid transfer protein (GLTP) Vfa1 PF08432.5 CDF87941.1 - 3 7.8 11.1 5.3 7.0 7.7 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Brix PF04427.13 CDF87942.1 - 2.7e-56 190.2 5.7 5e-56 189.3 3.9 1.4 1 0 0 1 1 1 1 Brix domain FYVE PF01363.16 CDF87943.1 - 8.1e-19 67.2 11.3 8.1e-19 67.2 7.9 3.4 3 2 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.1 CDF87943.1 - 3.6e-10 39.5 1.5 3.6e-10 39.5 1.1 4.2 4 1 0 4 4 4 1 Ring finger domain FANCL_C PF11793.3 CDF87943.1 - 0.0012 18.7 2.3 0.0012 18.7 1.6 3.1 4 0 0 4 4 4 1 FANCL C-terminal domain zf-C3HC4 PF00097.20 CDF87943.1 - 0.0015 18.1 2.6 0.0015 18.1 1.8 4.5 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 CDF87943.1 - 0.0016 18.0 1.1 0.0016 18.0 0.7 3.6 3 0 0 3 3 3 1 RING-type zinc-finger zf-rbx1 PF12678.2 CDF87943.1 - 0.003 17.6 0.5 0.003 17.6 0.4 3.6 3 1 0 3 3 3 2 RING-H2 zinc finger zf-C3HC4_2 PF13923.1 CDF87943.1 - 0.004 17.1 3.6 0.004 17.1 2.5 4.3 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 CDF87943.1 - 0.094 12.5 0.4 0.094 12.5 0.3 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.1 CDF87943.1 - 1.5 8.6 26.1 0.15 11.7 1.0 4.3 4 0 0 4 4 4 0 zinc-RING finger domain FYVE_2 PF02318.11 CDF87943.1 - 1.7 8.5 15.7 0.063 13.1 3.9 2.6 2 1 0 2 2 2 0 FYVE-type zinc finger BHD_1 PF10403.4 CDF87944.1 - 8.5e-13 47.6 0.1 2.3e-12 46.2 0.1 1.8 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.4 CDF87944.1 - 1.2e-10 41.5 0.7 3.9e-10 39.8 0.5 2.0 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 2 Rad4 PF03835.10 CDF87944.1 - 1.3e-05 24.6 0.0 2.8e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.4 CDF87944.1 - 4.2e-05 23.1 0.0 9.7e-05 22.0 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 MaoC_dehydrat_N PF13452.1 CDF87945.1 - 0.02 14.6 0.0 3.5 7.4 0.0 2.2 2 0 0 2 2 2 0 N-terminal half of MaoC dehydratase Ins_P5_2-kin PF06090.7 CDF87946.1 - 1.1e-40 139.6 4.4 2.7e-40 138.3 3.1 1.5 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase DUF1284 PF06935.6 CDF87946.1 - 0.11 12.7 3.0 1 9.5 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1284) DS PF01916.12 CDF87947.1 - 1.6e-146 487.1 0.0 1.9e-146 486.8 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Methyltransf_23 PF13489.1 CDF87948.1 - 2.2e-16 60.0 0.0 4.5e-16 58.9 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDF87948.1 - 3e-12 46.8 0.4 2.6e-11 43.8 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDF87948.1 - 1.7e-07 31.6 0.0 0.01 16.3 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.13 CDF87948.1 - 2e-07 30.4 0.1 0.0057 15.7 0.0 2.2 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 CDF87948.1 - 6e-07 30.0 0.0 2.1e-06 28.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDF87948.1 - 1.3e-06 28.7 0.0 3.7e-06 27.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDF87948.1 - 4.2e-06 26.4 0.0 2.3e-05 24.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain ECR1_N PF14382.1 CDF87949.1 - 1e-13 50.3 0.0 2.4e-13 49.1 0.0 1.7 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region EXOSC1 PF10447.4 CDF87949.1 - 0.018 14.9 0.0 0.37 10.7 0.0 2.8 2 1 0 2 2 2 0 Exosome component EXOSC1/CSL4 Met_10 PF02475.11 CDF87950.1 - 3.9e-74 248.5 0.0 6.3e-74 247.9 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein MethyltransfD12 PF02086.10 CDF87950.1 - 0.0048 16.3 0.0 0.01 15.3 0.0 1.6 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase Methyltransf_18 PF12847.2 CDF87950.1 - 0.017 15.7 0.0 0.041 14.4 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain TRM PF02005.11 CDF87950.1 - 0.02 13.8 0.0 0.031 13.2 0.0 1.2 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase PrmA PF06325.8 CDF87950.1 - 0.06 12.4 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Med10 PF09748.4 CDF87950.1 - 0.21 11.4 1.7 2.8 7.7 0.0 2.9 4 0 0 4 4 4 0 Transcription factor subunit Med10 of Mediator complex Cyclin PF08613.6 CDF87951.1 - 3.4e-08 34.0 0.2 5.6e-08 33.3 0.0 1.5 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.18 CDF87951.1 - 3e-07 30.0 0.2 4.6e-07 29.4 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain GAF_2 PF13185.1 CDF87952.1 - 5.1e-07 30.2 0.0 6e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 GAF domain GAF PF01590.21 CDF87952.1 - 6.6e-05 23.0 0.0 7.8e-05 22.8 0.0 1.3 1 1 0 1 1 1 1 GAF domain FBA_1 PF07734.8 CDF87952.1 - 0.091 12.4 0.0 0.12 12.1 0.0 1.4 1 1 0 1 1 1 0 F-box associated GAF_3 PF13492.1 CDF87952.1 - 0.11 12.6 0.0 0.14 12.2 0.0 1.4 1 1 0 1 1 1 0 GAF domain bHLH-MYC_N PF14215.1 CDF87952.1 - 0.14 12.3 0.3 0.36 11.0 0.0 1.7 2 0 0 2 2 2 0 bHLH-MYC and R2R3-MYB transcription factors N-terminal Pkinase_C PF00433.19 CDF87953.1 - 0.0095 16.4 0.0 0.019 15.4 0.0 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain ApoC-I PF04691.7 CDF87953.1 - 0.067 12.8 0.7 0.37 10.5 0.0 2.3 3 0 0 3 3 3 0 Apolipoprotein C-I (ApoC-1) TipAS PF07739.8 CDF87953.1 - 0.1 12.8 0.5 0.76 10.1 0.0 2.3 2 1 0 2 2 2 0 TipAS antibiotic-recognition domain TSKS PF15358.1 CDF87953.1 - 0.11 10.6 1.2 0.14 10.2 0.8 1.2 1 0 0 1 1 1 0 Testis-specific serine kinase substrate AKNA PF12443.3 CDF87953.1 - 0.15 12.0 1.6 0.48 10.4 0.2 2.5 2 1 0 2 2 2 0 AT-hook-containing transcription factor DUF342 PF03961.8 CDF87953.1 - 5.8 5.2 8.0 5.4 5.3 4.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF342) CNP1 PF08750.6 CDF87954.1 - 0.02 14.5 0.2 0.055 13.1 0.2 1.7 1 0 0 1 1 1 0 CNP1-like family V_ATPase_I PF01496.14 CDF87955.1 - 6.2e-281 933.7 1.1 7e-281 933.5 0.8 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Spc7 PF08317.6 CDF87955.1 - 0.87 8.1 5.0 4.8 5.7 0.3 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein HSP70 PF00012.15 CDF87956.1 - 1.5e-56 191.5 5.7 1.5e-56 191.5 4.0 2.0 2 0 0 2 2 2 1 Hsp70 protein Hydantoinase_A PF01968.13 CDF87956.1 - 2.3e-05 23.6 0.2 0.0019 17.3 0.0 2.4 1 1 1 2 2 2 2 Hydantoinase/oxoprolinase MreB_Mbl PF06723.8 CDF87956.1 - 0.0027 16.3 0.0 0.17 10.4 0.1 2.1 2 0 0 2 2 2 2 MreB/Mbl protein RIX1 PF08167.7 CDF87956.1 - 0.037 13.7 0.0 12 5.5 0.0 2.8 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis RRM_5 PF13893.1 CDF87957.1 - 0.047 13.5 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mito_carr PF00153.22 CDF87958.1 - 9.6e-70 230.3 4.5 4.4e-24 84.0 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Cu-oxidase_2 PF07731.9 CDF87959.1 - 6.9e-47 158.4 6.2 4.9e-40 136.2 0.6 2.9 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.10 CDF87959.1 - 3.5e-43 146.0 3.8 2.1e-38 130.7 0.6 3.3 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 CDF87959.1 - 1.2e-34 119.5 5.7 9.1e-31 106.9 0.5 4.3 3 1 1 4 4 4 2 Multicopper oxidase Cupredoxin_1 PF13473.1 CDF87959.1 - 0.00046 20.0 0.0 0.04 13.8 0.0 3.4 3 1 0 3 3 3 1 Cupredoxin-like domain DUF2430 PF10353.4 CDF87959.1 - 0.024 14.8 0.2 0.081 13.1 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2430) PetG PF02529.10 CDF87959.1 - 0.14 11.6 0.7 0.28 10.7 0.5 1.4 1 0 0 1 1 1 0 Cytochrome B6-F complex subunit 5 DUF4448 PF14610.1 CDF87961.1 - 5.2e-56 189.1 0.4 7.5e-56 188.6 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Tom37_C PF11801.3 CDF87962.1 - 7.9e-39 133.2 0.7 1.3e-38 132.5 0.5 1.3 1 0 0 1 1 1 1 Tom37 C-terminal domain Tom37 PF10568.4 CDF87962.1 - 7.5e-20 70.9 0.0 1.4e-19 70.1 0.0 1.5 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein Suf PF05843.9 CDF87963.1 - 8.4e-76 255.3 10.9 2.1e-65 221.2 3.1 3.6 2 1 1 3 3 3 3 Suppressor of forked protein (Suf) TPR_11 PF13414.1 CDF87963.1 - 0.00022 20.7 1.1 1.2 8.7 0.0 3.5 3 0 0 3 3 3 1 TPR repeat TPR_14 PF13428.1 CDF87963.1 - 0.00029 21.2 0.0 0.0062 17.0 0.0 3.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.1 CDF87963.1 - 0.0013 19.0 0.4 1.9 8.9 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 CDF87963.1 - 0.0093 16.3 1.3 2.2 8.9 0.4 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF842 PF05811.8 CDF87963.1 - 0.011 15.2 1.7 0.025 14.0 1.2 1.5 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) TPR_7 PF13176.1 CDF87963.1 - 0.015 15.0 3.1 22 5.1 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.12 CDF87963.1 - 0.15 12.0 3.8 12 6.1 0.8 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat ArgJ PF01960.13 CDF87964.1 - 1.3e-145 484.6 6.0 1.5e-145 484.5 4.2 1.0 1 0 0 1 1 1 1 ArgJ family Sugar_tr PF00083.19 CDF87965.1 - 1.6e-109 366.4 27.2 2e-109 366.1 18.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CDF87965.1 - 4.3e-24 84.8 27.2 3e-19 68.9 5.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CDF87966.1 - 1.3e-105 353.6 27.9 1.5e-105 353.3 19.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CDF87966.1 - 6.6e-27 94.1 35.1 1e-19 70.4 6.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3040 PF11239.3 CDF87966.1 - 0.34 11.0 1.6 1.7 8.7 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) HA2 PF04408.18 CDF87967.1 - 2.6e-19 69.1 0.1 5.2e-19 68.1 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 CDF87967.1 - 1.3e-13 50.7 0.0 2.4e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 CDF87967.1 - 3.1e-12 46.1 0.4 1.2e-11 44.3 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.24 CDF87967.1 - 5.2e-07 29.3 0.1 1.2e-06 28.1 0.1 1.6 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 CDF87967.1 - 2.8e-05 24.2 0.1 8.2e-05 22.7 0.1 1.7 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 CDF87967.1 - 0.0023 17.1 0.0 0.0039 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 CDF87967.1 - 0.0026 17.2 0.0 0.0054 16.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.22 CDF87967.1 - 0.0047 17.2 0.1 0.058 13.6 0.0 2.2 1 1 1 2 2 2 1 ABC transporter AAA_30 PF13604.1 CDF87967.1 - 0.05 13.1 0.0 0.086 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 CDF87967.1 - 0.07 12.0 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_14 PF13173.1 CDF87967.1 - 0.19 11.6 0.0 0.55 10.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain ResIII PF04851.10 CDF87967.1 - 0.22 11.3 0.1 11 5.7 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit SUR7 PF06687.7 CDF87968.1 - 7.1e-23 81.2 16.3 9.3e-23 80.9 11.3 1.1 1 0 0 1 1 1 1 SUR7/PalI family DUF4191 PF13829.1 CDF87968.1 - 0.0057 15.7 0.2 0.014 14.5 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4191) Tht1 PF04163.7 CDF87969.1 - 1.4e-55 188.8 26.2 2.4e-55 187.9 18.2 1.3 1 1 0 1 1 1 1 Tht1-like nuclear fusion protein Apolipoprotein PF01442.13 CDF87969.1 - 0.018 14.5 0.3 0.97 8.9 0.1 2.4 1 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF4164 PF13747.1 CDF87969.1 - 0.082 13.0 1.2 0.31 11.1 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) ApoLp-III PF07464.6 CDF87969.1 - 0.25 11.3 5.8 0.58 10.1 0.4 3.0 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Baculo_PEP_C PF04513.7 CDF87969.1 - 0.66 9.8 7.7 1.2 8.9 0.2 3.0 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Carbpep_Y_N PF05388.6 CDF87969.1 - 1.5 9.0 8.0 2.4 8.3 0.1 3.7 2 1 2 4 4 4 0 Carboxypeptidase Y pro-peptide Kinesin PF00225.18 CDF87970.1 - 4.3e-67 226.1 5.9 4.3e-67 226.1 4.1 2.2 2 0 0 2 2 2 1 Kinesin motor domain DUF365 PF04033.7 CDF87970.1 - 0.05 13.5 0.5 3.5 7.6 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF365) V-ATPase_C PF03223.10 CDF87971.1 - 9.9e-121 403.1 0.5 1.1e-120 402.9 0.3 1.0 1 0 0 1 1 1 1 V-ATPase subunit C NUC130_3NT PF08158.7 CDF87971.1 - 0.0061 16.8 0.5 1.6 9.0 0.0 2.5 2 0 0 2 2 2 2 NUC130/3NT domain EF1G PF00647.14 CDF87972.1 - 1.1e-45 153.7 0.1 1.9e-45 152.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.20 CDF87972.1 - 5.9e-11 42.2 0.1 5.9e-11 42.2 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 CDF87972.1 - 8.6e-10 38.6 0.0 7.7e-09 35.6 0.0 2.5 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 CDF87972.1 - 5.9e-06 26.6 1.0 8.1e-06 26.2 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.1 CDF87972.1 - 0.0017 18.5 0.0 0.0034 17.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 CDF87972.1 - 0.015 15.1 0.0 0.032 14.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain SURF6 PF04935.7 CDF87973.1 - 8.6e-48 162.4 51.9 8.6e-48 162.4 35.9 3.2 2 1 0 2 2 2 1 Surfeit locus protein 6 RRP14 PF15459.1 CDF87973.1 - 9.9e-19 67.1 5.0 9.9e-19 67.1 3.4 7.6 5 2 1 6 6 6 1 60S ribosome biogenesis protein Rrp14 DUF4224 PF13986.1 CDF87973.1 - 0.046 13.2 0.2 0.13 11.8 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4224) DUF217 PF02697.9 CDF87974.1 - 0.26 11.5 7.2 0.61 10.3 0.6 3.5 3 0 0 3 3 3 0 Uncharacterized ACR, COG1753 TUG-UBL1 PF11470.3 CDF87975.1 - 1.2e-25 89.1 0.0 7.6e-25 86.6 0.0 2.4 2 0 0 2 2 2 1 GLUT4 regulating protein TUG UBX PF00789.15 CDF87975.1 - 1.4e-10 41.0 0.0 3.8e-10 39.6 0.0 1.8 1 0 0 1 1 1 1 UBX domain RA PF00788.18 CDF87975.1 - 0.016 15.7 0.0 0.078 13.4 0.0 2.2 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain Rad60-SLD PF11976.3 CDF87975.1 - 0.041 13.5 0.1 5.7 6.6 0.0 3.1 3 0 0 3 3 3 0 Ubiquitin-2 like Rad60 SUMO-like Ank_2 PF12796.2 CDF87976.1 - 5.1e-24 84.4 0.2 4.2e-12 46.2 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CDF87976.1 - 8.1e-23 80.3 1.2 2.3e-06 27.9 0.2 5.3 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.25 CDF87976.1 - 1.2e-21 75.3 7.0 1.1e-05 24.9 0.0 5.5 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.1 CDF87976.1 - 2.6e-13 49.7 1.1 7.1e-06 26.1 0.0 4.3 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDF87976.1 - 3e-12 45.5 5.4 0.029 14.6 0.1 5.7 6 0 0 6 6 6 4 Ankyrin repeat zf-CHY PF05495.7 CDF87977.1 - 2e-15 56.6 12.8 2.5e-15 56.3 8.8 1.2 1 0 0 1 1 1 1 CHY zinc finger Cytochrome_C7 PF14522.1 CDF87977.1 - 0.015 14.9 4.0 0.028 14.0 2.8 1.5 1 0 0 1 1 1 0 Cytochrome c7 Glyco_hydro_2_C PF02836.12 CDF87977.1 - 0.13 11.1 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain A2L_zn_ribbon PF08792.5 CDF87977.1 - 0.31 10.5 6.8 0.077 12.4 1.3 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain zinc_ribbon_5 PF13719.1 CDF87977.1 - 0.38 10.3 0.3 0.38 10.3 0.2 3.1 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 CDF87977.1 - 0.46 10.2 0.3 0.46 10.2 0.2 3.1 3 0 0 3 3 3 0 zinc-ribbon domain DUF3762 PF12591.3 CDF87977.1 - 1.2 9.2 4.3 0.35 10.9 0.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3762) DZR PF12773.2 CDF87977.1 - 9.6 6.1 11.3 0.9 9.4 1.4 2.4 2 1 0 2 2 2 0 Double zinc ribbon FYVE_2 PF02318.11 CDF87977.1 - 9.8 6.1 9.9 3 7.7 0.8 2.0 1 1 1 2 2 2 0 FYVE-type zinc finger Ldh_1_C PF02866.13 CDF87978.1 - 1.1e-47 162.0 0.1 1.7e-47 161.4 0.1 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.18 CDF87978.1 - 1.4e-43 148.0 0.0 2e-43 147.6 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.14 CDF87978.1 - 2.1e-05 23.3 0.0 3e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.11 CDF87978.1 - 0.025 13.8 0.1 1.2 8.3 0.0 2.3 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase NAD_binding_10 PF13460.1 CDF87978.1 - 0.025 14.5 0.2 0.073 13.0 0.2 1.7 1 1 0 1 1 1 0 NADH(P)-binding THF_DHG_CYH_C PF02882.14 CDF87978.1 - 0.076 12.0 0.0 0.65 9.0 0.0 2.3 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ParBc PF02195.13 CDF87979.1 - 7.3e-15 54.8 0.0 8.6e-15 54.6 0.0 1.1 1 0 0 1 1 1 1 ParB-like nuclease domain G-alpha PF00503.15 CDF87980.1 - 3.1e-119 398.1 6.3 4.1e-119 397.7 4.4 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.16 CDF87980.1 - 3.2e-14 52.5 4.8 3.1e-10 39.5 0.0 2.8 3 0 0 3 3 3 2 ADP-ribosylation factor family Gtr1_RagA PF04670.7 CDF87980.1 - 0.00024 20.3 0.7 0.03 13.4 0.0 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Miro PF08477.8 CDF87980.1 - 0.0028 18.1 0.5 3.2 8.2 0.0 3.0 3 0 0 3 3 3 2 Miro-like protein GTP_EFTU PF00009.22 CDF87980.1 - 0.051 13.0 0.1 1.7 8.0 0.0 2.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CDF87980.1 - 0.082 12.8 0.0 17 5.4 0.0 2.7 3 0 0 3 3 3 0 50S ribosome-binding GTPase AAA_29 PF13555.1 CDF87980.1 - 0.13 11.8 0.1 0.27 10.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Cyto_heme_lyase PF01265.12 CDF87981.1 - 6.7e-86 288.0 7.1 3e-83 279.3 1.8 2.0 1 1 1 2 2 2 2 Cytochrome c/c1 heme lyase CDI PF02234.14 CDF87981.1 - 0.065 13.0 0.9 4.2 7.2 0.1 3.2 1 1 2 3 3 3 0 Cyclin-dependent kinase inhibitor zf-Tim10_DDP PF02953.10 CDF87982.1 - 7.9e-25 85.9 2.8 9.7e-25 85.6 1.9 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.8 CDF87982.1 - 0.023 14.1 3.5 0.032 13.7 2.4 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) GT36_AF PF06205.6 CDF87982.1 - 0.038 13.7 0.0 1.1 8.9 0.0 2.1 2 0 0 2 2 2 0 Glycosyltransferase 36 associated family Flavoprotein PF02441.14 CDF87983.1 - 8.4e-42 141.8 0.0 1.3e-41 141.2 0.0 1.3 1 0 0 1 1 1 1 Flavoprotein DUF2457 PF10446.4 CDF87983.1 - 0.97 8.0 38.1 1.6 7.3 26.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.9 CDF87983.1 - 3.8 5.4 24.6 5.5 4.8 17.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Sigma70_ner PF04546.8 CDF87983.1 - 4.8 6.7 24.7 8.4 5.9 17.1 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region DNA_pol_phi PF04931.8 CDF87983.1 - 5.1 4.7 36.0 6.5 4.3 25.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi Sporozoite_P67 PF05642.6 CDF87984.1 - 0.39 8.5 6.2 0.52 8.1 4.3 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Ydc2-catalyt PF09159.5 CDF87985.1 - 2e-48 165.2 0.1 2.8e-48 164.7 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Pox_A22 PF04848.8 CDF87985.1 - 0.0048 16.7 0.7 8 6.3 0.1 3.5 2 2 1 3 3 3 2 Poxvirus A22 protein RGS PF00615.14 CDF87985.1 - 0.12 12.4 1.1 0.69 10.0 0.1 2.3 2 1 0 2 2 2 0 Regulator of G protein signaling domain Peptidase_S24 PF00717.18 CDF87986.1 - 2.1e-07 30.4 0.1 3.5e-07 29.7 0.1 1.4 1 0 0 1 1 1 1 Peptidase S24-like FF PF01846.14 CDF87987.1 - 1.2e-30 105.1 17.3 7.3e-13 48.2 0.5 5.4 5 0 0 5 5 5 3 FF domain WW PF00397.21 CDF87987.1 - 1.7e-19 69.2 8.7 1.2e-10 41.0 0.6 2.6 2 0 0 2 2 2 2 WW domain PsbP PF01789.11 CDF87987.1 - 0.032 13.6 0.7 3.2 7.1 0.0 2.6 2 0 0 2 2 2 0 PsbP PQQ PF01011.16 CDF87987.1 - 0.13 11.8 0.3 0.34 10.5 0.0 1.8 2 0 0 2 2 2 0 PQQ enzyme repeat ARPC4 PF05856.7 CDF87988.1 - 5.8e-72 240.5 3.9 6.5e-72 240.4 2.7 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Fungal_trans PF04082.13 CDF87989.1 - 5e-26 91.1 1.8 5e-26 91.1 1.3 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF87989.1 - 7.2e-05 22.6 7.3 7.2e-05 22.6 5.0 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pepsin-I3 PF06394.8 CDF87990.1 - 0.51 10.0 2.7 0.77 9.4 0.5 2.0 2 0 0 2 2 2 0 Pepsin inhibitor-3-like repeated domain Npa1 PF11707.3 CDF87991.1 - 2.4e-91 306.1 4.0 2.4e-91 306.1 2.8 2.6 3 0 0 3 3 3 1 Ribosome 60S biogenesis N-terminal ASL_C PF08328.6 CDF87991.1 - 0.0015 18.3 0.9 2.7 7.8 0.0 4.0 4 0 0 4 4 4 2 Adenylosuccinate lyase C-terminal Fungal_trans PF04082.13 CDF87992.1 - 6e-24 84.3 0.1 1.2e-23 83.3 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF87992.1 - 8.7e-08 31.9 7.6 1.5e-07 31.1 5.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cep57_MT_bd PF06657.8 CDF87992.1 - 0.025 14.4 1.4 0.1 12.5 1.0 2.0 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 EcoEI_R_C PF08463.5 CDF87992.1 - 0.067 13.0 1.4 0.21 11.4 1.0 1.8 1 0 0 1 1 1 0 EcoEI R protein C-terminal Mt_ATP-synt_D PF05873.7 CDF87993.1 - 3.1e-14 52.9 4.0 4e-14 52.5 2.8 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) EzrA PF06160.7 CDF87993.1 - 0.0027 15.9 5.7 0.012 13.7 0.4 2.0 1 1 1 2 2 2 2 Septation ring formation regulator, EzrA IFT57 PF10498.4 CDF87993.1 - 0.021 13.5 3.9 0.026 13.3 2.7 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Aida_N PF08910.5 CDF87993.1 - 0.048 13.9 1.8 0.075 13.2 0.8 1.7 1 1 0 1 1 1 0 Aida N-terminus LTXXQ PF07813.7 CDF87993.1 - 0.07 13.5 1.8 4.2 7.8 0.7 2.2 1 1 1 2 2 2 0 LTXXQ motif family protein DUF2408 PF10303.4 CDF87993.1 - 0.091 12.8 2.2 0.14 12.2 1.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) AIPR PF10592.4 CDF87993.1 - 0.092 12.0 1.5 0.12 11.7 1.0 1.2 1 1 0 1 1 1 0 AIPR protein DUF4201 PF13870.1 CDF87993.1 - 0.094 12.1 2.9 0.14 11.5 0.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Fib_alpha PF08702.5 CDF87993.1 - 0.1 12.7 0.9 0.17 12.0 0.6 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Cauli_AT PF03233.8 CDF87993.1 - 0.12 12.1 3.0 0.23 11.1 1.6 1.8 1 1 0 1 1 1 0 Aphid transmission protein DUF1664 PF07889.7 CDF87993.1 - 0.68 9.7 2.9 1.3 8.8 2.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF2497 PF10691.4 CDF87993.1 - 0.84 9.6 3.5 2.2 8.3 0.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2497) DUF3486 PF11985.3 CDF87993.1 - 1.1 9.2 6.8 0.18 11.8 2.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3486) Peptidase_M16 PF00675.15 CDF87994.1 - 7.3e-23 80.9 0.0 1.1e-22 80.3 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 CDF87994.1 - 4e-08 33.1 0.1 1.1e-07 31.6 0.0 1.8 2 0 0 2 2 2 1 Peptidase M16 inactive domain GST_C PF00043.20 CDF87996.1 - 4.8e-12 45.7 0.0 8.6e-12 44.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 CDF87996.1 - 1.2e-11 44.6 0.0 2.2e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 CDF87996.1 - 4.2e-07 30.0 0.0 1e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 CDF87996.1 - 3.2e-06 27.5 0.0 5e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 CDF87996.1 - 7.5e-06 25.8 0.0 1.4e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 CDF87996.1 - 0.00068 19.4 0.0 0.0018 18.1 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain MIP PF00230.15 CDF87997.1 - 7.1e-50 169.5 7.8 1.1e-49 168.9 5.4 1.2 1 0 0 1 1 1 1 Major intrinsic protein Corona_nucleoca PF00937.13 CDF87997.1 - 0.0026 16.7 9.8 0.0041 16.1 6.8 1.2 1 0 0 1 1 1 1 Coronavirus nucleocapsid protein Dak1 PF02733.12 CDF87998.1 - 2.8e-144 479.6 3.1 3.4e-144 479.3 2.2 1.1 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.12 CDF87998.1 - 8.3e-43 146.0 3.6 1.4e-42 145.3 2.0 1.8 2 0 0 2 2 2 1 DAK2 domain Nitr_red_alph_N PF14710.1 CDF87998.1 - 0.2 11.9 0.1 0.37 11.0 0.1 1.4 1 0 0 1 1 1 0 Respiratory nitrate reductase alpha N-terminal Aldo_ket_red PF00248.16 CDF88000.1 - 4.4e-66 222.6 0.0 4.9e-66 222.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family RHH_1 PF01402.16 CDF88000.1 - 0.78 9.7 3.0 5.5 7.0 0.1 3.2 3 0 0 3 3 3 0 Ribbon-helix-helix protein, copG family Zn_clus PF00172.13 CDF88001.1 - 5.1e-08 32.6 11.9 1e-07 31.7 8.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pyocin_S PF06958.7 CDF88002.1 - 0.12 12.7 5.4 0.17 12.2 3.7 1.4 1 1 0 1 1 1 0 S-type Pyocin SR-25 PF10500.4 CDF88002.1 - 0.55 9.6 11.6 0.7 9.3 8.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Plasmodium_Vir PF05795.6 CDF88002.1 - 0.64 9.1 2.5 0.76 8.9 1.7 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein ZZ PF00569.12 CDF88006.1 - 5.4e-10 38.6 7.7 5.4e-10 38.6 5.4 2.0 2 1 0 2 2 2 1 Zinc finger, ZZ type DUF3795 PF12675.2 CDF88006.1 - 0.95 9.6 10.1 0.18 11.9 4.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3795) TauD PF02668.11 CDF88008.1 - 1.1e-48 166.2 0.2 1.3e-48 165.8 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Asparaginase PF00710.15 CDF88009.1 - 7.3e-11 41.4 0.1 1.5e-10 40.4 0.1 1.4 1 1 0 1 1 1 1 Asparaginase zf-GRF PF06839.7 CDF88011.1 - 0.28 11.1 3.4 2.9 7.8 0.3 2.4 1 1 1 2 2 2 0 GRF zinc finger DUF3533 PF12051.3 CDF88012.1 - 1.3e-131 438.9 18.0 1.6e-131 438.6 12.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) MFS_1 PF07690.11 CDF88014.1 - 8.4e-43 146.4 48.6 7.7e-42 143.2 33.7 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CDF88014.1 - 1.9e-13 49.8 30.3 3.9e-13 48.7 11.2 2.8 2 1 1 3 3 3 2 Sugar (and other) transporter DUF1746 PF08508.5 CDF88014.1 - 0.012 15.4 0.1 0.012 15.4 0.1 2.8 3 0 0 3 3 3 0 Fungal domain of unknown function (DUF1746) AA_permease PF00324.16 CDF88015.1 - 8.7e-118 393.6 35.9 9.9e-118 393.4 24.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CDF88015.1 - 1.7e-32 112.4 40.1 2.2e-32 112.1 27.8 1.1 1 0 0 1 1 1 1 Amino acid permease MFS_1 PF07690.11 CDF88017.1 - 1.4e-21 76.6 13.2 2.2e-21 76.0 9.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily ADH_zinc_N PF00107.21 CDF88018.1 - 1.2e-10 41.0 0.0 2.9e-10 39.7 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CDF88018.1 - 4.7e-06 26.3 0.0 9.9e-06 25.2 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Bac_luciferase PF00296.15 CDF88019.1 - 1.3e-50 172.2 0.0 1.9e-50 171.7 0.0 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase FMO-like PF00743.14 CDF88020.1 - 3.9e-28 97.9 1.6 7e-16 57.5 0.0 3.6 3 1 1 4 4 4 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 CDF88020.1 - 6.3e-16 59.0 0.0 1.1e-08 35.4 0.0 3.1 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CDF88020.1 - 9.8e-10 38.6 0.0 0.0023 17.8 0.0 3.2 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CDF88020.1 - 7.5e-07 28.3 0.0 0.00034 19.6 0.0 3.2 2 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.1 CDF88020.1 - 5.2e-06 26.3 0.0 0.025 14.3 0.0 4.1 3 1 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.19 CDF88020.1 - 0.00019 20.4 0.0 0.12 11.1 0.0 2.5 3 0 0 3 3 3 2 FAD dependent oxidoreductase HI0933_like PF03486.9 CDF88020.1 - 0.0069 14.8 0.1 0.16 10.3 0.0 2.5 2 1 1 3 3 3 1 HI0933-like protein NAD_binding_8 PF13450.1 CDF88020.1 - 0.0082 16.1 1.7 0.11 12.5 0.1 2.9 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 CDF88020.1 - 0.13 11.3 0.1 0.99 8.4 0.0 2.1 2 0 0 2 2 2 0 Thi4 family Malic_M PF03949.10 CDF88020.1 - 0.15 11.5 0.0 1.6 8.2 0.0 2.1 2 0 0 2 2 2 0 Malic enzyme, NAD binding domain FAD_binding_2 PF00890.19 CDF88020.1 - 0.21 10.3 0.1 0.31 9.8 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain SSF PF00474.12 CDF88021.1 - 1e-25 90.2 24.1 1.6e-25 89.6 16.7 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family BEX PF04538.7 CDF88021.1 - 0.56 10.4 4.3 0.96 9.6 3.0 1.3 1 0 0 1 1 1 0 Brain expressed X-linked like family Glyco_hydro_32N PF00251.15 CDF88022.1 - 3.8e-78 262.9 10.5 5.4e-78 262.4 7.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.7 CDF88022.1 - 3.1e-09 37.0 1.0 1.3e-08 35.1 0.4 2.3 2 0 0 2 2 2 1 Glycosyl hydrolases family 32 C terminal Epimerase PF01370.16 CDF88023.1 - 4.7e-20 72.0 0.0 6.4e-20 71.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.7 CDF88023.1 - 1e-13 50.8 0.0 9.1e-13 47.7 0.0 1.9 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.14 CDF88023.1 - 1.6e-13 50.0 0.0 2.2e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 CDF88023.1 - 2.7e-09 37.2 0.0 7.5e-09 35.8 0.0 1.8 1 1 0 1 1 1 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 CDF88023.1 - 1.3e-06 27.5 0.1 4.3e-06 25.8 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein adh_short PF00106.20 CDF88023.1 - 3e-06 27.2 0.1 1.6e-05 24.8 0.0 2.1 2 1 0 2 2 2 1 short chain dehydrogenase NmrA PF05368.8 CDF88023.1 - 6.5e-06 25.5 0.0 0.00079 18.7 0.0 2.3 2 1 0 2 2 2 1 NmrA-like family Saccharop_dh PF03435.13 CDF88023.1 - 0.001 18.1 0.0 0.0032 16.5 0.0 1.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase KR PF08659.5 CDF88023.1 - 0.0053 16.4 0.0 0.013 15.1 0.0 1.6 1 0 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.12 CDF88023.1 - 0.021 13.7 0.0 0.038 12.8 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain F420_oxidored PF03807.12 CDF88023.1 - 0.034 14.5 0.0 0.1 13.0 0.0 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.15 CDF88023.1 - 0.11 12.6 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Zip PF02535.17 CDF88024.1 - 4.8e-52 176.9 1.4 5.6e-52 176.7 1.0 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter NfeD PF01957.13 CDF88024.1 - 0.48 10.5 0.0 0.48 10.5 0.0 2.4 3 1 0 3 3 3 0 NfeD-like C-terminal, partner-binding RRM_1 PF00076.17 CDF88026.1 - 0.00022 20.7 0.0 0.031 13.9 0.0 2.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF88026.1 - 0.0025 17.6 0.0 0.044 13.6 0.0 2.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF88026.1 - 0.015 15.2 0.0 0.059 13.3 0.0 2.1 1 1 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Rot1 PF10681.4 CDF88026.1 - 0.43 9.8 2.8 0.16 11.3 0.1 1.6 2 0 0 2 2 2 0 Chaperone for protein-folding within the ER, fungal LMBR1 PF04791.11 CDF88026.1 - 1.2 7.6 6.6 4.3 5.7 4.6 1.8 1 1 0 1 1 1 0 LMBR1-like membrane protein NGP1NT PF08153.7 CDF88027.1 - 1.9e-48 163.6 1.3 4.2e-48 162.5 0.9 1.6 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.18 CDF88027.1 - 9.6e-20 70.6 0.1 3.9e-15 55.8 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.13 CDF88027.1 - 2e-05 23.9 0.0 9.6e-05 21.7 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B DUF258 PF03193.11 CDF88027.1 - 0.00037 19.7 0.0 0.00085 18.5 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Arf PF00025.16 CDF88027.1 - 0.00045 19.5 0.1 0.085 12.0 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Dynamin_N PF00350.18 CDF88027.1 - 0.00056 19.7 8.3 0.33 10.7 0.0 4.1 3 1 1 4 4 4 2 Dynamin family GTP_EFTU PF00009.22 CDF88027.1 - 0.0046 16.4 0.0 1.2 8.4 0.0 3.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain SusD-like_3 PF14322.1 CDF88027.1 - 0.027 14.5 0.2 0.06 13.4 0.1 1.6 1 0 0 1 1 1 0 Starch-binding associating with outer membrane CAF1 PF04857.15 CDF88028.1 - 8.7e-53 179.3 1.5 1.3e-52 178.7 1.0 1.2 1 0 0 1 1 1 1 CAF1 family ribonuclease NTF2 PF02136.15 CDF88029.1 - 2.1e-20 73.2 0.4 9.6e-20 71.1 0.1 2.1 2 0 0 2 2 2 1 Nuclear transport factor 2 (NTF2) domain Y_phosphatase2 PF03162.8 CDF88030.1 - 1.7e-36 125.0 1.7 2.7e-35 121.1 1.2 2.2 1 1 0 1 1 1 1 Tyrosine phosphatase family DUF1366 PF07104.6 CDF88030.1 - 0.063 12.8 0.0 0.58 9.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1366) Xol-1_GHMP-like PF09109.5 CDF88030.1 - 0.081 12.9 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Switch protein XOL-1, GHMP-like Saccharop_dh PF03435.13 CDF88031.1 - 1.8e-129 432.0 0.0 2.1e-129 431.9 0.0 1.0 1 0 0 1 1 1 1 Saccharopine dehydrogenase Shikimate_DH PF01488.15 CDF88031.1 - 1.7e-07 31.3 0.0 2.9e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.1 CDF88031.1 - 3.9e-05 23.7 0.3 0.00019 21.5 0.1 1.9 2 0 0 2 2 2 1 NADH(P)-binding F420_oxidored PF03807.12 CDF88031.1 - 0.00024 21.4 0.1 0.00057 20.2 0.1 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_3 PF03447.11 CDF88031.1 - 0.023 15.1 0.1 0.043 14.2 0.1 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain 3Beta_HSD PF01073.14 CDF88031.1 - 0.025 13.2 0.0 0.036 12.7 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Mso1_Sec1_bdg PF14475.1 CDF88032.1 - 1.7e-18 65.7 0.1 3.1e-18 64.8 0.0 1.4 1 0 0 1 1 1 1 Sec1-binding region of Mso1 NRDE-2 PF08424.5 CDF88032.1 - 0.27 10.0 3.3 0.19 10.5 1.2 1.5 1 1 0 1 1 1 0 NRDE-2, necessary for RNA interference CDC50 PF03381.10 CDF88033.1 - 1.4e-97 326.2 0.9 1.6e-97 325.9 0.6 1.0 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Not1 PF04054.10 CDF88034.1 - 6.6e-136 453.1 7.5 6.6e-136 453.1 5.2 3.0 4 0 0 4 4 4 1 CCR4-Not complex component, Not1 DUF3819 PF12842.2 CDF88034.1 - 1e-41 142.0 1.8 4.1e-41 140.0 1.2 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) MutS_V PF00488.16 CDF88035.1 - 4.8e-77 258.5 0.1 3e-76 255.9 0.0 2.1 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.13 CDF88035.1 - 1.1e-33 116.8 0.1 2.5e-33 115.5 0.1 1.7 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.15 CDF88035.1 - 2.1e-27 95.4 0.1 6.8e-27 93.7 0.0 2.0 2 0 0 2 2 2 1 MutS domain I MutS_IV PF05190.13 CDF88035.1 - 5.3e-10 39.3 2.4 1.1e-09 38.3 0.6 2.4 2 0 0 2 2 2 1 MutS family domain IV MutS_II PF05188.12 CDF88035.1 - 1.9e-09 37.6 0.6 2.4e-08 34.1 0.0 3.2 3 1 0 3 3 3 1 MutS domain II Pkinase PF00069.20 CDF88036.1 - 2.8e-74 249.5 0.0 4.9e-74 248.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF88036.1 - 1.2e-31 109.7 0.0 1.7e-30 105.9 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF88036.1 - 3.3e-07 29.5 0.1 0.00018 20.5 0.0 2.5 1 1 1 2 2 2 2 Kinase-like Trm112p PF03966.11 CDF88037.1 - 2e-20 72.8 0.2 2.5e-20 72.6 0.1 1.1 1 0 0 1 1 1 1 Trm112p-like protein ADK_lid PF05191.9 CDF88037.1 - 0.12 12.0 0.7 0.32 10.6 0.5 1.8 1 0 0 1 1 1 0 Adenylate kinase, active site lid UPF0158 PF03682.8 CDF88038.1 - 0.0023 17.5 0.4 0.0048 16.5 0.2 1.5 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0158) Ins_allergen_rp PF06757.8 CDF88038.1 - 0.0032 16.9 0.5 0.0074 15.7 0.1 1.9 2 0 0 2 2 2 1 Insect allergen related repeat, nitrile-specifier detoxification DUF866 PF05907.8 CDF88039.1 - 9.5e-29 99.9 3.0 2.8e-26 91.9 2.0 2.0 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) RNA_pol_N PF01194.12 CDF88039.1 - 0.0092 15.9 0.1 0.021 14.8 0.1 1.6 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit DUF581 PF04570.9 CDF88039.1 - 0.19 11.0 0.0 0.19 11.0 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF581) zf-DNL PF05180.7 CDF88039.1 - 1 9.1 3.5 1.4 8.6 0.1 2.5 3 0 0 3 3 3 0 DNL zinc finger Flocculin_t3 PF13928.1 CDF88040.1 - 2.9e-20 72.1 155.3 2.5e-06 27.5 6.7 20.7 20 3 0 20 20 20 9 Flocculin type 3 repeat Cofilin_ADF PF00241.15 CDF88041.1 - 1.4e-22 79.9 0.0 2.1e-22 79.3 0.0 1.2 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_1 PF00018.23 CDF88041.1 - 1.4e-15 56.3 0.3 2.8e-15 55.4 0.2 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 CDF88041.1 - 1.2e-14 53.5 0.1 2.4e-14 52.6 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 CDF88041.1 - 4.3e-07 29.3 0.0 9.2e-07 28.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain GST_C_2 PF13410.1 CDF88042.1 - 6e-07 29.2 0.0 1.4e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.1 CDF88042.1 - 6.4e-07 29.2 0.0 1.4e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 CDF88042.1 - 9.9e-07 28.9 0.0 2.7e-06 27.4 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.1 CDF88042.1 - 0.00043 20.6 0.0 0.00079 19.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 CDF88042.1 - 0.049 13.6 0.0 0.093 12.7 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain zf-LYAR PF08790.6 CDF88043.1 - 8.4e-15 54.1 6.6 2.3e-14 52.7 4.6 1.8 1 0 0 1 1 1 1 LYAR-type C2HC zinc finger zf-met PF12874.2 CDF88043.1 - 0.062 13.5 7.4 2.1 8.7 0.3 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 CDF88043.1 - 0.2 11.8 7.7 0.5 10.5 0.6 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding AIF_C PF14721.1 CDF88043.1 - 0.27 11.4 4.1 0.4 10.9 2.6 1.5 1 1 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term zf-GRF PF06839.7 CDF88043.1 - 0.29 11.1 4.0 0.85 9.6 2.8 1.8 1 0 0 1 1 1 0 GRF zinc finger zf-C2H2_6 PF13912.1 CDF88043.1 - 0.29 11.0 5.8 0.77 9.7 1.1 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger A2L_zn_ribbon PF08792.5 CDF88043.1 - 0.33 10.4 8.2 0.29 10.6 1.6 2.9 1 1 1 2 2 2 0 A2L zinc ribbon domain XPA_N PF01286.13 CDF88043.1 - 0.33 10.6 4.5 4 7.2 0.2 2.6 2 0 0 2 2 2 0 XPA protein N-terminal zf-C2H2_4 PF13894.1 CDF88043.1 - 0.45 10.9 6.8 94 3.7 2.6 3.5 2 1 0 2 2 2 0 C2H2-type zinc finger Presenilin PF01080.12 CDF88043.1 - 0.48 9.1 4.4 0.56 8.9 3.0 1.1 1 0 0 1 1 1 0 Presenilin RNHCP PF12647.2 CDF88043.1 - 0.73 9.7 4.2 1.5 8.7 1.9 2.2 1 1 1 2 2 2 0 RNHCP domain COX6B PF02297.12 CDF88043.1 - 1.8 8.6 11.8 0.047 13.7 3.3 2.0 2 1 0 2 2 2 0 Cytochrome oxidase c subunit VIb zf-C2H2 PF00096.21 CDF88043.1 - 2 8.9 9.6 0.96 9.9 0.7 3.7 2 1 1 3 3 3 0 Zinc finger, C2H2 type C1_4 PF07975.7 CDF88043.1 - 2.5 8.2 6.6 4.5 7.3 3.7 2.2 1 1 1 2 2 2 0 TFIIH C1-like domain zf-DNL PF05180.7 CDF88043.1 - 3.3 7.4 6.7 25 4.6 4.4 2.5 1 1 1 2 2 2 0 DNL zinc finger Zn-ribbon_8 PF09723.5 CDF88043.1 - 8.2 6.4 9.1 2.3 8.2 1.1 2.6 2 0 0 2 2 2 0 Zinc ribbon domain Csm1 PF12539.3 CDF88044.1 - 1.4e-33 115.2 0.0 2.7e-33 114.3 0.0 1.5 1 0 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 DUF16 PF01519.11 CDF88044.1 - 0.00027 21.1 1.4 0.00062 19.9 0.7 1.7 2 0 0 2 2 2 1 Protein of unknown function DUF16 Complex1_49kDa PF00346.14 CDF88044.1 - 0.0039 16.2 0.1 0.012 14.6 0.0 1.7 2 0 0 2 2 2 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit SPATA24 PF15175.1 CDF88044.1 - 0.0053 16.4 0.9 0.0086 15.7 0.6 1.4 1 0 0 1 1 1 1 Spermatogenesis-associated protein 24 ORF6C PF10552.4 CDF88044.1 - 0.039 13.6 1.2 0.048 13.3 0.3 1.5 2 0 0 2 2 2 0 ORF6C domain Atg14 PF10186.4 CDF88044.1 - 0.047 12.6 1.7 0.067 12.1 1.2 1.2 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 TMF_DNA_bd PF12329.3 CDF88044.1 - 0.054 13.3 4.8 0.13 12.0 3.2 1.8 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Uds1 PF15456.1 CDF88044.1 - 0.057 13.4 0.9 0.097 12.6 0.6 1.4 1 0 0 1 1 1 0 Up-regulated During Septation IncA PF04156.9 CDF88044.1 - 0.061 12.9 2.7 0.1 12.2 1.8 1.4 1 0 0 1 1 1 0 IncA protein LemA PF04011.7 CDF88044.1 - 0.064 12.3 0.9 0.1 11.6 0.6 1.3 1 0 0 1 1 1 0 LemA family DUF3482 PF11981.3 CDF88044.1 - 0.067 12.4 1.3 0.084 12.0 0.4 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3482) DUF4140 PF13600.1 CDF88044.1 - 0.076 13.4 0.6 0.31 11.5 0.4 2.0 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF2205 PF10224.4 CDF88044.1 - 0.13 11.8 3.2 8.9 5.9 0.7 2.5 1 1 1 2 2 2 0 Predicted coiled-coil protein (DUF2205) Med9 PF07544.8 CDF88044.1 - 0.13 12.0 2.5 0.23 11.1 1.8 1.5 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 CCDC155 PF14662.1 CDF88044.1 - 0.14 11.7 5.9 0.12 11.9 2.9 1.7 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 XhlA PF10779.4 CDF88044.1 - 0.37 10.7 2.9 0.73 9.7 2.0 1.5 1 0 0 1 1 1 0 Haemolysin XhlA DivIC PF04977.10 CDF88044.1 - 0.61 9.6 3.7 0.99 8.9 2.0 1.8 1 1 0 1 1 1 0 Septum formation initiator WD40 PF00400.27 CDF88045.1 - 1.3e-58 192.9 15.6 2.6e-10 39.7 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.5 CDF88045.1 - 9.2e-31 105.8 14.6 9.2e-31 105.8 10.1 2.8 3 0 0 3 3 3 1 Tup N-terminal Nup160 PF11715.3 CDF88045.1 - 2.4e-06 25.9 1.9 0.19 9.8 0.2 3.7 1 1 3 4 4 4 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.6 CDF88045.1 - 0.0071 15.1 1.4 1.5 7.4 0.0 3.5 3 1 0 3 3 3 2 Nup133 N terminal like UbiA PF01040.13 CDF88046.1 - 1.5e-33 116.1 19.4 1.9e-33 115.7 13.4 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Thioredoxin PF00085.15 CDF88048.1 - 5.4e-28 96.7 0.0 6.4e-28 96.4 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 CDF88048.1 - 2.1e-06 27.7 0.0 3.3e-05 23.8 0.0 2.1 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.1 CDF88048.1 - 6.8e-06 26.2 0.1 8e-05 22.8 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Redoxin PF08534.5 CDF88048.1 - 4.9e-05 22.8 0.1 0.0048 16.4 0.0 2.1 1 1 1 2 2 2 1 Redoxin TraF PF13728.1 CDF88048.1 - 0.00016 21.1 0.0 0.0002 20.9 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_9 PF14595.1 CDF88048.1 - 0.00091 18.8 0.0 0.001 18.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.16 CDF88048.1 - 0.0022 17.6 0.1 0.0044 16.6 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family Glutaredoxin PF00462.19 CDF88048.1 - 0.0058 16.6 0.1 0.0097 15.8 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.1 CDF88048.1 - 0.059 13.1 0.1 0.1 12.3 0.0 1.4 1 1 0 1 1 1 0 Thioredoxin domain DSBA PF01323.15 CDF88048.1 - 0.11 12.0 0.3 2.5 7.6 0.0 2.1 1 1 1 2 2 2 0 DSBA-like thioredoxin domain SYCE1 PF15233.1 CDF88049.1 - 0.094 12.6 0.4 0.1 12.5 0.3 1.2 1 0 0 1 1 1 0 Synaptonemal complex central element protein 1 Mannosyl_trans3 PF11051.3 CDF88050.1 - 7.8e-79 264.8 0.0 1.2e-78 264.1 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative muHD PF10291.4 CDF88051.1 - 1.9e-66 223.8 0.0 3.8e-66 222.9 0.0 1.5 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.18 CDF88051.1 - 0.00056 20.0 0.6 0.00056 20.0 0.4 2.4 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SSB PF00436.20 CDF88053.1 - 1.8e-17 63.1 0.1 2.1e-17 62.8 0.1 1.1 1 0 0 1 1 1 1 Single-strand binding protein family Gon7 PF08738.5 CDF88054.1 - 3.4e-32 110.4 0.2 4.1e-32 110.2 0.2 1.0 1 0 0 1 1 1 1 Gon7 family MFS_1 PF07690.11 CDF88055.1 - 4.3e-22 78.2 24.5 6.4e-22 77.7 17.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3792 PF12670.2 CDF88055.1 - 3.3 7.6 9.2 0.14 11.9 1.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3792) Glyco_transf_34 PF05637.7 CDF88056.1 - 3.4e-54 183.8 0.1 4.4e-54 183.5 0.1 1.1 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Fibrinogen_BP PF08017.6 CDF88057.1 - 0.039 12.1 0.4 0.068 11.3 0.3 1.3 1 0 0 1 1 1 0 Fibrinogen binding protein ATP12 PF07542.6 CDF88058.1 - 5.1e-33 113.6 0.0 9.3e-33 112.7 0.0 1.4 1 0 0 1 1 1 1 ATP12 chaperone protein Prefoldin_2 PF01920.15 CDF88059.1 - 8.1e-15 54.4 3.1 9e-15 54.3 2.1 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF948 PF06103.6 CDF88059.1 - 0.0035 17.1 3.7 0.053 13.3 0.1 2.1 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF948) Sipho_Gp157 PF05565.6 CDF88059.1 - 0.013 15.1 0.5 0.013 15.1 0.3 1.7 2 0 0 2 2 2 0 Siphovirus Gp157 DUF3560 PF12083.3 CDF88059.1 - 0.034 14.1 0.4 0.45 10.5 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3560) CCDC142 PF14923.1 CDF88059.1 - 0.074 11.3 0.2 0.09 11.0 0.1 1.2 1 0 0 1 1 1 0 Coiled-coil protein 142 Viral_P18 PF04521.8 CDF88059.1 - 0.15 11.5 2.4 0.56 9.6 0.5 2.0 2 0 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein Seryl_tRNA_N PF02403.17 CDF88059.1 - 0.18 11.8 4.4 1.8 8.5 0.1 2.1 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain CENP-F_leu_zip PF10473.4 CDF88059.1 - 0.25 11.2 5.4 0.57 10.0 1.4 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TBPIP PF07106.8 CDF88059.1 - 0.26 10.8 5.7 2.7 7.5 0.1 2.1 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Syntaxin-6_N PF09177.6 CDF88059.1 - 0.28 11.6 2.0 8.2 6.9 0.4 2.2 2 0 0 2 2 2 0 Syntaxin 6, N-terminal ORF6C PF10552.4 CDF88059.1 - 0.29 10.8 2.9 1.6 8.4 1.8 1.9 1 1 0 1 1 1 0 ORF6C domain NPV_P10 PF05531.7 CDF88059.1 - 0.47 10.7 4.0 12 6.2 0.4 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF16 PF01519.11 CDF88059.1 - 1.2 9.3 4.9 5.8 7.2 3.4 1.9 1 1 0 1 1 1 0 Protein of unknown function DUF16 HR1 PF02185.11 CDF88059.1 - 1.6 8.5 6.0 0.38 10.5 1.8 1.7 2 0 0 2 2 2 0 Hr1 repeat FlaC_arch PF05377.6 CDF88059.1 - 2.3 8.2 4.8 4 7.4 0.3 2.4 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) XhlA PF10779.4 CDF88059.1 - 2.8 7.9 6.0 2.2 8.2 0.1 2.1 2 0 0 2 2 2 0 Haemolysin XhlA TMF_TATA_bd PF12325.3 CDF88059.1 - 6.9 6.4 8.2 3.6 7.3 2.2 2.3 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding ATG27 PF09451.5 CDF88060.1 - 6.5e-58 196.0 0.1 8.2e-58 195.7 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 LMBR1 PF04791.11 CDF88060.1 - 0.077 11.5 0.0 5 5.5 0.0 2.0 2 0 0 2 2 2 0 LMBR1-like membrane protein MCC-bdg_PDZ PF10506.4 CDF88061.1 - 0.011 15.5 0.2 0.021 14.6 0.2 1.4 1 0 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Ribosomal_L34e PF01199.13 CDF88062.1 - 1.6e-36 124.3 4.3 1.6e-36 124.3 3.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L34e zf-3CxxC PF13695.1 CDF88062.1 - 0.29 11.3 4.1 0.21 11.8 1.0 1.9 1 1 1 2 2 2 0 Zinc-binding domain Transp_cyt_pur PF02133.10 CDF88063.1 - 6.7e-87 291.8 29.9 7.8e-87 291.6 20.7 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF2678 PF10856.3 CDF88063.1 - 1.4 8.6 11.2 0.075 12.7 3.1 2.5 2 2 1 3 3 3 0 Protein of unknown function (DUF2678) Steroid_dh PF02544.11 CDF88064.1 - 7e-08 32.3 3.7 7e-08 32.3 2.6 2.0 1 1 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase E1-E2_ATPase PF00122.15 CDF88065.1 - 5e-29 100.9 0.1 1e-28 99.9 0.1 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 CDF88065.1 - 5.8e-14 53.0 0.0 3.6e-13 50.4 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 CDF88065.1 - 2.4e-11 44.1 0.0 5.1e-11 43.0 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CDF88065.1 - 1.6e-09 37.5 0.1 6.7e-09 35.5 0.0 2.1 2 0 0 2 2 2 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 CDF88065.1 - 0.0048 16.5 0.3 0.018 14.6 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase EXS PF03124.9 CDF88066.1 - 2.2e-85 286.7 22.4 3.1e-85 286.2 15.5 1.2 1 0 0 1 1 1 1 EXS family SPX PF03105.14 CDF88066.1 - 6.3e-37 127.8 5.5 1.5e-36 126.6 3.8 1.6 1 1 0 1 1 1 1 SPX domain HisG PF01634.13 CDF88067.1 - 9e-53 178.1 0.1 1.4e-52 177.5 0.1 1.3 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.6 CDF88067.1 - 3.8e-28 97.2 0.0 7.1e-28 96.3 0.0 1.5 1 0 0 1 1 1 1 HisG, C-terminal domain NMT1 PF09084.6 CDF88067.1 - 0.018 14.6 0.1 0.029 13.9 0.1 1.3 1 0 0 1 1 1 0 NMT1/THI5 like WD40 PF00400.27 CDF88068.1 - 1.9e-49 163.8 26.6 2.6e-09 36.6 0.6 7.5 8 0 0 8 8 8 6 WD domain, G-beta repeat F-box-like PF12937.2 CDF88068.1 - 5.4e-14 51.6 2.7 1.2e-13 50.5 1.9 1.6 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.3 CDF88068.1 - 1.1e-09 37.0 7.8 0.083 11.0 0.0 4.9 2 2 2 5 5 5 4 Nucleoporin Nup120/160 F-box PF00646.28 CDF88068.1 - 1.3e-09 37.4 1.2 3.3e-09 36.1 0.8 1.7 1 0 0 1 1 1 1 F-box domain Nucleoporin_N PF08801.6 CDF88068.1 - 0.0022 16.8 0.3 0.38 9.4 0.0 3.4 1 1 1 3 3 3 1 Nup133 N terminal like eIF2A PF08662.6 CDF88068.1 - 0.087 12.5 0.2 6.6 6.3 0.0 2.6 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A CBM_21 PF03370.8 CDF88069.1 - 3.7e-25 88.0 0.0 5.6e-25 87.5 0.0 1.3 1 0 0 1 1 1 1 Putative phosphatase regulatory subunit Mito_carr PF00153.22 CDF88070.1 - 8.3e-50 166.4 4.6 3.7e-17 61.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein ArfGap PF01412.13 CDF88071.1 - 5.4e-36 122.9 0.2 5.4e-36 122.9 0.1 1.7 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Synaphin PF05835.7 CDF88071.1 - 0.011 15.8 0.2 0.021 14.9 0.1 1.4 1 0 0 1 1 1 0 Synaphin protein BAF1_ABF1 PF04684.8 CDF88071.1 - 0.11 11.3 5.3 0.14 10.9 3.7 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Cyt-b5 PF00173.23 CDF88072.1 - 3.3e-20 71.6 0.0 6.3e-20 70.7 0.0 1.5 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain AA_kinase PF00696.23 CDF88073.1 - 5e-40 137.5 0.0 8.7e-40 136.7 0.0 1.4 1 0 0 1 1 1 1 Amino acid kinase family ACT PF01842.20 CDF88073.1 - 1.8e-10 40.0 1.5 1e-06 28.0 0.6 2.6 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.1 CDF88073.1 - 8.9e-08 31.5 2.1 1.3e-05 24.5 0.5 2.5 2 0 0 2 2 2 2 ACT domain DCD PF06559.6 CDF88073.1 - 0.073 11.4 0.0 0.12 10.7 0.0 1.2 1 0 0 1 1 1 0 2'-deoxycytidine 5'-triphosphate deaminase (DCD) NAD_binding_1 PF00175.16 CDF88074.1 - 2.4e-31 108.5 0.0 3.5e-31 107.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 CDF88074.1 - 1.6e-27 95.5 0.0 2.9e-27 94.6 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 CDF88074.1 - 4.1e-07 30.0 0.0 0.0057 16.5 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain GBP_repeat PF02526.9 CDF88074.1 - 0.12 11.7 0.0 0.3 10.4 0.0 1.7 1 0 0 1 1 1 0 Glycophorin-binding protein Cupin_8 PF13621.1 CDF88075.1 - 3.1e-09 36.7 1.6 2.2e-08 33.9 1.1 2.2 1 1 0 1 1 1 1 Cupin-like domain PHD PF00628.24 CDF88075.1 - 3e-05 23.6 5.2 7.8e-05 22.2 3.6 1.7 1 1 0 1 1 1 1 PHD-finger JmjC PF02373.17 CDF88075.1 - 0.00029 21.0 0.1 0.0029 17.8 0.0 2.7 2 1 0 2 2 2 1 JmjC domain, hydroxylase DUF1423 PF07227.6 CDF88075.1 - 0.0015 17.3 0.7 0.0024 16.6 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1423) Cupin_4 PF08007.7 CDF88075.1 - 0.014 14.6 1.7 0.064 12.4 0.0 2.4 3 0 0 3 3 3 0 Cupin superfamily protein C1_1 PF00130.17 CDF88075.1 - 0.13 12.0 3.6 0.41 10.4 2.5 1.9 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Ribosomal_S18 PF01084.15 CDF88076.1 - 9.4e-18 63.8 0.0 2.8e-17 62.3 0.0 1.9 1 0 0 1 1 1 1 Ribosomal protein S18 BAR_2 PF10455.4 CDF88077.1 - 1.3e-81 273.7 11.2 1.8e-81 273.2 6.9 1.8 1 1 1 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.13 CDF88077.1 - 5.3e-14 52.2 10.8 3.6e-13 49.5 7.5 2.1 1 1 0 1 1 1 1 BAR domain BLOC1_2 PF10046.4 CDF88077.1 - 9.2 6.4 8.6 10 6.3 0.1 3.1 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Ofd1_CTDD PF10637.4 CDF88078.1 - 6.7e-93 310.6 3.9 3e-89 298.6 2.6 2.5 2 1 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_3 PF13640.1 CDF88078.1 - 1.1e-14 54.7 0.1 3e-14 53.3 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Ribonuc_2-5A PF06479.7 CDF88078.1 - 0.067 13.0 0.3 0.067 13.0 0.2 2.0 2 0 0 2 2 2 0 Ribonuclease 2-5A AAA_21 PF13304.1 CDF88078.1 - 4.8 7.0 10.3 0.9 9.4 0.6 2.2 2 0 0 2 2 2 0 AAA domain Complex1_LYR PF05347.10 CDF88079.1 - 7.7e-17 60.8 0.4 9.8e-17 60.5 0.3 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 CDF88079.1 - 4.8e-16 58.7 0.5 5.9e-16 58.4 0.4 1.1 1 0 0 1 1 1 1 Complex1_LYR-like DUF1851 PF08906.6 CDF88079.1 - 0.059 13.3 0.2 0.11 12.4 0.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1851) Pox_polyA_pol_N PF12630.2 CDF88079.1 - 0.37 10.8 2.3 0.65 10.1 1.6 1.5 1 1 0 1 1 1 0 Poxvirus poly(A) polymerase N-terminal domain Apq12 PF12716.2 CDF88080.1 - 1.7e-06 27.6 11.2 1.7e-06 27.6 7.8 2.0 2 0 0 2 2 2 1 Nuclear pore assembly and biogenesis Peptidase_M50B PF13398.1 CDF88080.1 - 0.0017 17.7 5.5 0.0021 17.4 3.8 1.1 1 0 0 1 1 1 1 Peptidase M50B-like O-antigen_lig PF13425.1 CDF88080.1 - 0.11 12.4 5.2 0.13 12.2 3.6 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Wzy_C PF04932.10 CDF88080.1 - 0.14 11.9 3.8 0.15 11.8 2.6 1.1 1 0 0 1 1 1 0 O-Antigen ligase DUF4131 PF13567.1 CDF88080.1 - 0.53 9.6 5.4 0.84 9.0 3.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) YibE_F PF07907.6 CDF88080.1 - 1.4 8.0 9.5 1.8 7.6 6.6 1.1 1 0 0 1 1 1 0 YibE/F-like protein DnaJ-X PF14308.1 CDF88081.1 - 5.5e-61 205.4 7.8 5.5e-61 205.4 5.4 2.1 1 1 1 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.26 CDF88081.1 - 3e-24 84.5 0.9 3e-24 84.5 0.6 3.4 4 0 0 4 4 4 1 DnaJ domain Joubert PF15392.1 CDF88081.1 - 0.0047 16.2 0.9 0.016 14.4 0.6 1.9 2 0 0 2 2 2 1 Joubert syndrome-associated PRKCSH-like PF12999.2 CDF88081.1 - 0.01 15.4 0.3 0.11 12.0 0.1 2.4 2 0 0 2 2 2 0 Glucosidase II beta subunit-like Spore_YhcN_YlaJ PF09580.5 CDF88081.1 - 0.045 13.8 5.9 0.18 11.8 4.2 1.7 1 1 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) CobN-Mg_chel PF02514.11 CDF88081.1 - 0.057 10.8 8.4 0.066 10.6 5.8 1.1 1 0 0 1 1 1 0 CobN/Magnesium Chelatase YflT PF11181.3 CDF88081.1 - 0.057 13.5 2.1 0.12 12.5 0.3 2.4 1 1 1 2 2 2 0 Heat induced stress protein YflT Metallophos PF00149.23 CDF88082.1 - 3.2e-27 95.2 9.7 3.2e-27 95.2 6.8 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase TauD PF02668.11 CDF88084.1 - 7.1e-48 163.5 0.0 9.5e-48 163.1 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family 2OG-FeII_Oxy_3 PF13640.1 CDF88084.1 - 0.024 15.1 0.8 0.55 10.7 0.0 2.6 2 1 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily Not3 PF04065.10 CDF88085.1 - 6.9e-92 306.9 24.8 1.9e-91 305.5 17.2 1.8 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.13 CDF88085.1 - 5.9e-28 97.4 0.1 1.9e-27 95.7 0.1 1.9 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family bZIP_1 PF00170.16 CDF88088.1 - 5.5e-15 55.0 4.4 6.5e-15 54.8 2.1 1.7 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.10 CDF88088.1 - 0.00016 21.4 7.0 0.00016 21.4 4.9 1.7 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.12 CDF88088.1 - 0.0086 16.3 1.3 0.019 15.2 0.9 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor Pkinase PF00069.20 CDF88090.1 - 4.4e-52 176.8 5.1 7.1e-51 172.8 3.5 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF88090.1 - 1.1e-19 70.5 0.9 8.9e-15 54.4 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.18 CDF88090.1 - 4.4e-05 23.3 0.3 0.00015 21.5 0.2 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 CDF88090.1 - 0.0032 17.0 0.9 0.011 15.2 0.6 1.9 1 1 0 1 1 1 1 Choline/ethanolamine kinase DUF496 PF04363.7 CDF88090.1 - 0.58 9.9 5.0 0.28 10.9 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF496) F_actin_cap_B PF01115.12 CDF88091.1 - 4.4e-96 320.7 0.1 5.3e-96 320.5 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit Erg28 PF03694.8 CDF88092.1 - 5.8e-45 151.8 0.3 7.3e-45 151.5 0.2 1.1 1 0 0 1 1 1 1 Erg28 like protein MtN3_slv PF03083.11 CDF88092.1 - 0.0073 16.1 1.5 0.012 15.4 0.1 1.9 1 1 1 2 2 2 1 Sugar efflux transporter for intercellular exchange cNMP_binding PF00027.24 CDF88093.1 - 1.4e-43 146.6 0.1 2.5e-22 78.4 0.0 2.7 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain RIIa PF02197.12 CDF88093.1 - 2.9e-09 36.2 4.3 3.6e-09 35.8 1.7 2.2 2 0 0 2 2 2 1 Regulatory subunit of type II PKA R-subunit CFTR_R PF14396.1 CDF88093.1 - 0.01 15.2 0.0 0.02 14.2 0.0 1.4 1 0 0 1 1 1 0 Cystic fibrosis TM conductance regulator (CFTR), regulator domain Gluconate_2-dh3 PF13618.1 CDF88093.1 - 0.049 13.7 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 SNF2_N PF00176.18 CDF88094.1 - 2.7e-69 233.2 0.1 4.3e-69 232.5 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CDF88094.1 - 2.3e-14 52.9 0.0 1.1e-12 47.6 0.0 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDF88094.1 - 5.7e-09 36.0 1.1 3.3e-07 30.3 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.3 CDF88094.1 - 1.4e-06 27.3 0.7 4.3e-06 25.7 0.1 2.1 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.24 CDF88094.1 - 3.5e-05 23.3 0.0 0.00013 21.4 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.1 CDF88094.1 - 0.03 14.4 0.1 0.15 12.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain SWIRM PF04433.12 CDF88095.1 - 2.1e-32 111.0 1.1 5.3e-32 109.7 0.1 2.2 2 0 0 2 2 2 1 SWIRM domain ZZ PF00569.12 CDF88095.1 - 1.6e-14 53.1 3.4 2.6e-14 52.4 2.3 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.26 CDF88095.1 - 1.9e-06 27.7 0.2 4e-06 26.7 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CDF88095.1 - 8.9e-06 25.7 0.2 5.3e-05 23.2 0.0 2.5 2 0 0 2 2 2 1 Myb-like DNA-binding domain Elf1 PF05129.8 CDF88095.1 - 0.026 14.1 0.3 0.071 12.8 0.2 1.7 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like PSII_Pbs27 PF13326.1 CDF88095.1 - 0.034 14.1 1.5 0.051 13.5 0.4 1.8 2 0 0 2 2 2 0 Photosystem II Pbs27 Zip PF02535.17 CDF88096.1 - 2.7e-53 181.0 29.0 1.5e-52 178.6 13.3 3.0 2 1 0 2 2 2 1 ZIP Zinc transporter YrhC PF14143.1 CDF88096.1 - 5.1 7.1 5.8 1.1 9.2 0.0 2.9 4 0 0 4 4 4 0 YrhC-like protein STAG PF08514.6 CDF88098.1 - 8.6e-09 35.1 0.5 3.7e-08 33.1 0.3 2.1 1 0 0 1 1 1 1 STAG domain HEAT PF02985.17 CDF88098.1 - 0.11 12.6 3.0 18 5.7 0.0 4.0 4 0 0 4 4 4 0 HEAT repeat MMgT PF10270.4 CDF88099.1 - 1e-22 80.5 0.0 1.2e-22 80.3 0.0 1.1 1 0 0 1 1 1 1 Membrane magnesium transporter APC_CDC26 PF10471.4 CDF88100.1 - 2.2e-12 47.5 7.1 3.7e-12 46.8 4.3 1.9 1 1 1 2 2 2 1 Anaphase-promoting complex APC subunit 1 RINGv PF12906.2 CDF88101.1 - 1.2e-14 54.0 5.9 2.3e-14 53.1 4.1 1.5 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.1 CDF88101.1 - 0.12 12.2 5.8 0.23 11.3 4.0 1.5 1 0 0 1 1 1 0 Ring finger domain FANCL_C PF11793.3 CDF88101.1 - 1.3 9.0 4.0 2.6 8.0 2.8 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain Peptidase_C48 PF02902.14 CDF88102.1 - 3e-36 125.0 3.2 3e-36 125.0 2.2 2.2 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain RNA_pol_A_bac PF01000.21 CDF88105.1 - 7.3e-32 109.8 0.3 1.9e-31 108.5 0.1 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 CDF88105.1 - 1e-13 50.1 0.0 1.6e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain HLH PF00010.21 CDF88107.1 - 3.7e-13 48.9 0.5 8e-13 47.8 0.4 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Viral_P18 PF04521.8 CDF88107.1 - 0.031 13.6 0.2 0.059 12.8 0.1 1.4 1 0 0 1 1 1 0 ssRNA positive strand viral 18kD cysteine rich protein EMP24_GP25L PF01105.19 CDF88107.1 - 0.3 10.7 2.1 0.55 9.9 1.5 1.4 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD UCR_hinge PF02320.11 CDF88108.1 - 9.1e-25 86.3 4.5 1.5e-24 85.6 3.1 1.4 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein DUF506 PF04720.7 CDF88108.1 - 0.023 14.3 3.6 0.026 14.1 2.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF506) Sigma70_ner PF04546.8 CDF88108.1 - 0.037 13.6 17.9 0.049 13.2 12.4 1.3 1 1 0 1 1 1 0 Sigma-70, non-essential region CDC45 PF02724.9 CDF88108.1 - 0.21 9.5 9.1 0.21 9.6 6.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.6 CDF88108.1 - 0.33 8.7 8.7 0.34 8.7 6.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2457 PF10446.4 CDF88108.1 - 0.35 9.5 22.1 0.46 9.1 15.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.7 CDF88108.1 - 0.57 8.0 17.7 0.58 8.0 12.3 1.0 1 0 0 1 1 1 0 Nop14-like family Utp14 PF04615.8 CDF88108.1 - 0.86 7.6 12.1 0.97 7.5 8.4 1.0 1 0 0 1 1 1 0 Utp14 protein YL1 PF05764.8 CDF88108.1 - 1.3 8.6 13.4 1.5 8.3 9.3 1.1 1 0 0 1 1 1 0 YL1 nuclear protein RRN3 PF05327.6 CDF88108.1 - 1.3 7.0 8.7 1.2 7.1 6.0 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 HAP1_N PF04849.8 CDF88108.1 - 1.3 7.8 9.6 1.7 7.4 6.7 1.3 1 0 0 1 1 1 0 HAP1 N-terminal conserved region Med17 PF10156.4 CDF88108.1 - 1.5 6.9 5.4 1.8 6.7 3.8 1.1 1 0 0 1 1 1 0 Subunit 17 of Mediator complex Bd3614_N PF14442.1 CDF88108.1 - 2.6 8.0 7.1 3.7 7.5 4.9 1.2 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal Daxx PF03344.10 CDF88108.1 - 2.7 6.3 20.1 3 6.2 13.9 1.1 1 0 0 1 1 1 0 Daxx Family SDA1 PF05285.7 CDF88108.1 - 6.2 6.0 18.4 6.9 5.8 12.7 1.1 1 0 0 1 1 1 0 SDA1 Retinal PF15449.1 CDF88108.1 - 6.5 4.2 6.1 7.8 4.0 4.2 1.0 1 0 0 1 1 1 0 Retinal protein Ribosomal_L29e PF01779.12 CDF88109.1 - 1.7e-24 85.3 13.3 2.2e-24 84.9 9.2 1.2 1 0 0 1 1 1 1 Ribosomal L29e protein family RRM_6 PF14259.1 CDF88110.1 - 7.6e-22 77.0 0.1 2.5e-14 53.0 0.0 3.2 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CDF88110.1 - 2.1e-19 68.9 0.3 1.1e-12 47.3 0.1 3.3 2 2 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF88110.1 - 1.9e-08 34.0 0.0 0.00081 19.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Agro_virD5 PF04730.7 CDF88110.1 - 0.0059 14.7 0.5 0.011 13.8 0.3 1.3 1 0 0 1 1 1 1 Agrobacterium VirD5 protein DbpA PF03880.10 CDF88110.1 - 0.031 13.9 0.8 21 4.8 0.1 3.5 3 0 0 3 3 3 0 DbpA RNA binding domain Ribosomal_L2_C PF03947.13 CDF88111.1 - 3e-40 137.0 3.4 4.5e-40 136.4 2.4 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 CDF88111.1 - 4.3e-13 49.0 1.2 6.3e-13 48.5 0.1 1.9 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain SMC_N PF02463.14 CDF88112.1 - 2.3e-72 242.8 0.0 7.4e-71 237.8 0.0 2.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 CDF88112.1 - 7.3e-21 74.3 1.4 2e-20 72.9 0.2 2.3 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.1 CDF88112.1 - 3.9e-17 63.2 2.6 3.9e-17 63.2 1.8 6.6 2 1 0 4 4 3 1 AAA domain AAA_21 PF13304.1 CDF88112.1 - 1.6e-09 38.1 27.2 5e-06 26.6 0.5 3.9 3 2 0 3 3 3 2 AAA domain GAS PF13851.1 CDF88112.1 - 1.2e-06 27.8 30.9 5.5e-05 22.4 9.4 7.6 3 2 5 8 8 8 3 Growth-arrest specific micro-tubule binding AAA_29 PF13555.1 CDF88112.1 - 2.4e-05 23.7 0.0 6.2e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain IFT57 PF10498.4 CDF88112.1 - 0.0011 17.7 12.5 0.0011 17.7 8.7 6.2 2 2 3 6 6 4 1 Intra-flagellar transport protein 57 Mnd1 PF03962.10 CDF88112.1 - 0.0012 18.5 12.1 0.0012 18.5 8.4 7.6 3 2 4 7 7 6 1 Mnd1 family ABC_tran PF00005.22 CDF88112.1 - 0.022 15.0 0.3 0.18 12.0 0.0 5.9 5 2 0 5 5 3 0 ABC transporter LPP PF04728.8 CDF88112.1 - 0.56 10.0 5.2 11 5.8 0.1 4.2 4 0 0 4 4 4 0 Lipoprotein leucine-zipper DUF3584 PF12128.3 CDF88112.1 - 1.1 6.4 76.4 0.13 9.6 21.7 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3584) Reo_sigmaC PF04582.7 CDF88112.1 - 2 7.5 36.7 0.38 9.8 0.5 6.2 2 2 5 7 7 7 0 Reovirus sigma C capsid protein AAA_17 PF13207.1 CDF88112.1 - 6.6 7.5 7.9 8 7.3 0.0 4.1 3 1 0 3 3 3 0 AAA domain FAD_binding_1 PF00667.15 CDF88113.1 - 5.6e-66 222.1 0.0 9.9e-66 221.3 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.16 CDF88113.1 - 1.1e-09 38.8 0.0 7.1e-09 36.2 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain CesA PF11439.3 CDF88113.1 - 0.0027 17.5 0.1 0.016 15.0 0.1 2.2 2 0 0 2 2 2 1 Type III secretion system filament chaperone CesA HEAT PF02985.17 CDF88114.1 - 0.0002 21.1 0.2 0.19 11.8 0.0 4.6 4 0 0 4 4 4 1 HEAT repeat Nop14 PF04147.7 CDF88114.1 - 0.45 8.3 16.4 3.3 5.5 0.3 3.4 3 0 0 3 3 3 0 Nop14-like family BAG PF02179.11 CDF88115.1 - 2.4e-16 59.6 2.7 2.4e-16 59.6 1.9 1.5 2 0 0 2 2 2 1 BAG domain Asp PF00026.18 CDF88116.1 - 2.7e-71 240.4 4.4 4.4e-71 239.7 3.1 1.3 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 CDF88116.1 - 2e-07 31.1 0.2 2e-07 31.1 0.2 2.0 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 CDF88116.1 - 0.026 14.0 0.2 1 8.8 0.0 2.9 2 1 0 2 2 2 0 Xylanase inhibitor C-terminal Lum_binding PF00677.12 CDF88117.1 - 1.4e-46 156.2 7.1 2.7e-23 81.6 0.6 2.2 2 0 0 2 2 2 2 Lumazine binding domain PQQ_2 PF13360.1 CDF88118.1 - 7e-10 38.7 0.1 8e-05 22.2 0.1 3.0 1 1 1 2 2 2 2 PQQ-like domain WD40 PF00400.27 CDF88118.1 - 1.8e-05 24.4 15.9 0.0041 16.9 0.5 6.5 7 1 1 8 8 8 3 WD domain, G-beta repeat PQQ_3 PF13570.1 CDF88118.1 - 0.067 13.4 1.0 1.9 8.8 0.0 3.5 4 0 0 4 4 4 0 PQQ-like domain Cut8_C PF08559.5 CDF88119.1 - 1.6e-42 144.7 0.8 3.5e-42 143.6 0.2 1.8 1 1 1 2 2 2 1 Cut8 six-helix bundle Cut8_M PF14483.1 CDF88119.1 - 1.5e-07 31.0 0.8 2.9e-07 30.1 0.6 1.5 1 0 0 1 1 1 1 Cut8 dimerisation domain Rad10 PF03834.9 CDF88119.1 - 0.44 10.2 2.3 0.35 10.6 0.4 1.7 2 0 0 2 2 2 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) Sedlin_N PF04628.8 CDF88122.1 - 5.5e-48 162.1 0.0 6.5e-48 161.9 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.7 CDF88122.1 - 8.4e-06 25.5 0.2 2.1e-05 24.2 0.1 1.8 1 1 0 1 1 1 1 Sybindin-like family MIS13 PF08202.6 CDF88123.1 - 5.6e-67 225.9 13.2 5.6e-67 225.9 9.1 1.5 2 0 0 2 2 2 1 Mis12-Mtw1 protein family DivIC PF04977.10 CDF88123.1 - 1.3 8.6 12.0 2.6 7.6 0.1 3.4 3 0 0 3 3 3 0 Septum formation initiator Pox_RNA_Pol_19 PF05320.7 CDF88123.1 - 2.9 7.6 7.4 14 5.4 0.0 3.0 3 0 0 3 3 3 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Med22 PF06179.7 CDF88124.1 - 2.3e-21 75.8 0.9 2.9e-21 75.5 0.6 1.0 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex DUF3281 PF11685.3 CDF88124.1 - 0.052 12.7 0.1 0.065 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3281) ATP_transf PF09830.4 CDF88124.1 - 0.087 12.6 0.3 0.22 11.3 0.1 1.8 2 1 0 2 2 2 0 ATP adenylyltransferase RESP18 PF14948.1 CDF88124.1 - 0.095 12.7 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 RESP18 domain dUTPase PF00692.14 CDF88125.1 - 6e-43 145.3 0.0 6.8e-43 145.2 0.0 1.0 1 0 0 1 1 1 1 dUTPase Ribosomal_S5 PF00333.15 CDF88126.1 - 6.3e-25 86.7 0.1 1.1e-24 85.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.10 CDF88126.1 - 6.8e-18 63.7 0.0 1.3e-17 62.7 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain HMG_box PF00505.14 CDF88127.1 - 1.7e-14 53.8 5.1 5.4e-14 52.2 3.5 1.8 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 CDF88127.1 - 7.1e-05 23.1 0.4 0.00015 22.0 0.3 1.5 1 1 0 1 1 1 1 HMG-box domain COX4 PF02936.9 CDF88127.1 - 0.031 14.0 0.1 0.047 13.4 0.1 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV Peptidase_M41 PF01434.13 CDF88128.1 - 1.7e-74 249.9 0.1 2.5e-74 249.3 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 CDF88128.1 - 3.3e-43 147.0 0.0 7.4e-43 145.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FtsH_ext PF06480.10 CDF88128.1 - 0.00023 21.2 0.1 0.00053 20.1 0.0 1.6 1 0 0 1 1 1 1 FtsH Extracellular AAA_17 PF13207.1 CDF88128.1 - 0.00048 20.9 0.0 0.0025 18.6 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CDF88128.1 - 0.0013 18.9 1.2 0.094 12.8 0.1 3.1 2 1 0 2 2 2 1 AAA domain TIP49 PF06068.8 CDF88128.1 - 0.0031 16.3 0.0 0.007 15.1 0.0 1.5 1 0 0 1 1 1 1 TIP49 C-terminus AAA_19 PF13245.1 CDF88128.1 - 0.0036 17.0 0.8 0.01 15.5 0.6 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 CDF88128.1 - 0.0058 16.3 0.1 0.034 13.8 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 CDF88128.1 - 0.0073 15.7 0.0 0.016 14.6 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein RuvB_N PF05496.7 CDF88128.1 - 0.0097 14.9 0.0 0.016 14.2 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 CDF88128.1 - 0.011 15.7 0.1 0.12 12.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 CDF88128.1 - 0.012 15.5 0.0 0.039 13.9 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.7 CDF88128.1 - 0.022 13.8 0.0 0.049 12.7 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_25 PF13481.1 CDF88128.1 - 0.059 12.7 1.2 0.14 11.5 0.4 1.9 1 1 1 2 2 2 0 AAA domain AAA_33 PF13671.1 CDF88128.1 - 0.094 12.5 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.1 CDF88128.1 - 0.11 12.4 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 CDF88128.1 - 0.31 11.3 0.0 0.31 11.3 0.0 2.9 3 0 0 3 3 3 0 AAA domain CDC45 PF02724.9 CDF88128.1 - 2.8 5.8 6.6 4 5.3 4.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Gag_spuma PF03276.9 CDF88128.1 - 4.6 5.4 7.6 7.8 4.6 5.2 1.3 1 0 0 1 1 1 0 Spumavirus gag protein EB1 PF03271.12 CDF88129.1 - 1.3e-18 66.7 0.2 2.6e-18 65.7 0.1 1.6 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.26 CDF88129.1 - 4.5e-07 29.8 1.4 9.4e-07 28.8 1.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain Sp100 PF03172.8 CDF88129.1 - 0.049 13.5 0.1 0.15 11.9 0.0 1.8 2 0 0 2 2 2 0 Sp100 domain AMP-binding PF00501.23 CDF88130.1 - 3e-72 243.2 0.0 4e-72 242.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme RRM_5 PF13893.1 CDF88131.1 - 1.8e-13 50.1 0.0 2.4e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CDF88131.1 - 9.5e-09 34.7 0.0 1.8e-08 33.9 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF88131.1 - 1.3e-07 31.5 0.0 2.7e-07 30.4 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 CDF88131.1 - 0.016 14.9 0.0 0.022 14.5 0.0 1.2 1 0 0 1 1 1 0 Limkain b1 SNURF PF07192.6 CDF88131.1 - 0.039 13.7 0.1 0.062 13.1 0.1 1.3 1 0 0 1 1 1 0 SNURF/RPN4 protein DUF1866 PF08952.6 CDF88131.1 - 0.082 12.4 0.0 0.091 12.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1866) NAD_binding_8 PF13450.1 CDF88132.1 - 2.7e-12 46.5 0.0 5.9e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.19 CDF88132.1 - 3.2e-06 26.5 0.2 1.2e-05 24.6 0.1 1.8 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.19 CDF88132.1 - 0.00032 19.7 0.0 0.00074 18.5 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.12 CDF88132.1 - 0.0027 16.8 0.0 0.0058 15.7 0.0 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.22 CDF88132.1 - 0.004 17.5 0.1 0.15 12.4 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CDF88132.1 - 0.06 13.1 0.0 0.17 11.6 0.0 1.8 2 0 0 2 2 2 0 FAD-NAD(P)-binding OB_NTP_bind PF07717.11 CDF88133.1 - 6.8e-26 90.3 0.0 2.2e-25 88.7 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.18 CDF88133.1 - 1.5e-24 85.9 0.0 6e-24 84.0 0.0 2.1 1 0 0 1 1 1 1 Helicase associated domain (HA2) S1 PF00575.18 CDF88133.1 - 8e-15 54.6 0.3 8e-15 54.6 0.2 2.6 3 0 0 3 3 3 1 S1 RNA binding domain Helicase_C PF00271.26 CDF88133.1 - 2e-12 46.7 0.1 1.3e-11 44.1 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 CDF88133.1 - 8.6e-06 25.9 0.0 2.2e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain DEAD PF00270.24 CDF88133.1 - 1.4e-05 24.6 0.1 4.1e-05 23.1 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SE PF00437.15 CDF88133.1 - 0.00016 20.6 0.0 0.00051 19.0 0.0 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_14 PF13173.1 CDF88133.1 - 0.014 15.2 0.5 0.28 11.1 0.2 2.9 2 1 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.1 CDF88133.1 - 0.027 14.4 0.0 0.082 12.9 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_19 PF13245.1 CDF88133.1 - 0.056 13.1 0.1 0.13 12.0 0.1 1.6 1 0 0 1 1 1 0 Part of AAA domain AAA_30 PF13604.1 CDF88133.1 - 0.11 12.1 0.1 0.24 10.9 0.1 1.5 1 0 0 1 1 1 0 AAA domain Proteasome PF00227.21 CDF88134.1 - 1.1e-40 139.0 0.0 1.2e-40 138.7 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Uteroglobin PF01099.12 CDF88134.1 - 0.038 13.8 0.0 0.069 12.9 0.0 1.4 1 0 0 1 1 1 0 Uteroglobin family DNA_primase_S PF01896.14 CDF88135.1 - 4e-52 175.8 0.6 7.5e-52 174.9 0.4 1.4 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase small subunit Cellulase PF00150.13 CDF88136.1 - 9.8e-12 44.6 0.0 4.4e-06 26.1 0.0 2.7 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_35 PF01301.14 CDF88136.1 - 0.0025 17.2 0.0 0.0049 16.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.10 CDF88136.1 - 0.011 14.8 0.0 0.02 14.0 0.0 1.3 1 0 0 1 1 1 0 Beta-galactosidase WSC PF01822.14 CDF88137.1 - 2e-12 46.8 14.2 2e-12 46.8 9.8 2.5 2 1 0 2 2 2 1 WSC domain DUF1191 PF06697.7 CDF88137.1 - 7.6e-05 21.6 0.6 0.00012 21.0 0.4 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1191) DUF2062 PF09835.4 CDF88137.1 - 0.004 16.7 0.0 0.0063 16.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2062) Neurensin PF14927.1 CDF88137.1 - 0.063 12.6 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 Neurensin DUF2762 PF10960.3 CDF88137.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2762) MCLC PF05934.6 CDF88137.1 - 7.2 4.7 6.6 10 4.3 4.6 1.2 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) DUF2408 PF10303.4 CDF88138.1 - 2.2e-80 267.3 15.2 3.9e-52 175.9 1.4 5.1 3 2 2 5 5 5 4 Protein of unknown function (DUF2408) AATF-Che1 PF13339.1 CDF88138.1 - 9.7 6.3 19.0 0.85 9.7 1.1 4.7 4 1 2 6 6 6 0 Apoptosis antagonizing transcription factor AhpC-TSA PF00578.16 CDF88139.1 - 2.2e-27 95.2 0.0 3e-27 94.7 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 CDF88139.1 - 2e-18 66.3 0.0 3e-18 65.7 0.0 1.2 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.1 CDF88139.1 - 0.0094 15.8 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme DUF1644 PF07800.7 CDF88139.1 - 0.11 12.3 1.1 0.21 11.4 0.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) CDC45 PF02724.9 CDF88139.1 - 0.11 10.4 6.3 0.15 10.0 4.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2072 PF09845.4 CDF88139.1 - 0.47 10.3 4.2 0.99 9.3 2.9 1.6 1 1 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) Adap_comp_sub PF00928.16 CDF88140.1 - 1.2e-85 286.7 0.2 1.6e-85 286.4 0.2 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.15 CDF88140.1 - 4.1e-08 33.0 3.2 4.1e-07 29.8 1.5 2.3 1 1 1 2 2 2 2 Clathrin adaptor complex small chain muHD PF10291.4 CDF88140.1 - 0.0039 16.3 0.1 0.014 14.5 0.0 1.8 2 0 0 2 2 2 1 Muniscin C-terminal mu homology domain TPP1 PF10341.4 CDF88141.1 - 7.3e-21 74.1 0.1 9.6e-21 73.7 0.1 1.2 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD DPM2 PF07297.7 CDF88142.1 - 1.7e-13 50.6 2.6 2e-13 50.4 1.8 1.1 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.7 CDF88142.1 - 0.022 14.4 4.3 0.025 14.2 3.0 1.1 1 0 0 1 1 1 0 PIG-P Oxidored_q4 PF00507.14 CDF88142.1 - 0.19 11.5 4.5 0.23 11.2 3.1 1.2 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 SRPRB PF09439.5 CDF88143.1 - 4.9e-62 208.3 0.0 6e-62 208.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.16 CDF88143.1 - 8.3e-08 31.6 0.0 1.2e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 CDF88143.1 - 1.6e-05 24.8 0.0 2.5e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 CDF88143.1 - 4.1e-05 22.8 0.0 5.8e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 CDF88143.1 - 0.00015 21.2 0.0 0.021 14.2 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain LNS2 PF08235.8 CDF88143.1 - 0.0086 15.6 0.0 0.012 15.1 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) AAA_23 PF13476.1 CDF88143.1 - 0.059 13.6 2.1 0.19 12.0 1.5 1.9 1 1 0 1 1 1 0 AAA domain MobB PF03205.9 CDF88143.1 - 0.064 12.9 0.1 0.41 10.3 0.0 2.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Miro PF08477.8 CDF88143.1 - 0.081 13.4 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 Miro-like protein ABC_tran PF00005.22 CDF88143.1 - 0.098 12.9 0.0 0.16 12.3 0.0 1.7 1 1 0 1 1 1 0 ABC transporter Rsm22 PF09243.5 CDF88144.1 - 6.5e-30 104.0 0.1 7.8e-11 41.5 0.0 4.3 3 1 0 3 3 3 3 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_23 PF13489.1 CDF88144.1 - 1.2e-05 25.1 0.0 2.5e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ribosomal_S27e PF01667.12 CDF88145.1 - 2.1e-30 103.9 2.7 2.9e-30 103.5 1.9 1.2 1 0 0 1 1 1 1 Ribosomal protein S27 IBR PF01485.16 CDF88145.1 - 2.8e-05 23.9 0.7 3.4e-05 23.6 0.5 1.1 1 0 0 1 1 1 1 IBR domain TF_Zn_Ribbon PF08271.7 CDF88145.1 - 0.051 12.9 3.8 0.074 12.3 2.6 1.2 1 0 0 1 1 1 0 TFIIB zinc-binding zinc_ribbon_5 PF13719.1 CDF88145.1 - 0.13 11.8 1.3 6.2 6.5 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 CDF88145.1 - 0.14 11.8 1.3 6.3 6.5 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Myosin_head PF00063.16 CDF88146.1 - 5.3e-249 827.9 8.6 5.3e-249 827.9 5.9 4.7 3 3 3 6 6 6 1 Myosin head (motor domain) CENP-F_leu_zip PF10473.4 CDF88146.1 - 0.11 12.3 0.1 0.11 12.3 0.1 12.5 3 3 9 12 12 12 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Peptidase_M16 PF00675.15 CDF88147.1 - 7.2e-45 152.3 0.0 4.1e-43 146.6 0.0 2.2 2 0 0 2 2 2 2 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 CDF88147.1 - 3.1e-43 147.5 0.0 1.1e-42 145.7 0.0 2.0 2 0 0 2 2 2 1 Peptidase M16 inactive domain STE PF02200.11 CDF88148.1 - 6.9e-59 196.7 3.9 1.1e-58 196.1 2.7 1.3 1 0 0 1 1 1 1 STE like transcription factor Tcf25 PF04910.9 CDF88149.1 - 1.8e-73 247.5 0.3 1.8e-73 247.5 0.2 1.8 2 0 0 2 2 2 1 Transcriptional repressor TCF25 SPT6_acidic PF14632.1 CDF88149.1 - 0.7 10.0 18.9 0.24 11.5 10.5 2.1 2 0 0 2 2 2 0 Acidic N-terminal SPT6 Ipi1_N PF12333.3 CDF88150.1 - 7e-25 86.9 0.6 7e-25 86.9 0.4 2.7 3 1 0 3 3 3 1 Rix1 complex component involved in 60S ribosome maturation Cnd1 PF12717.2 CDF88150.1 - 0.00096 19.0 3.4 0.0019 18.0 2.2 1.6 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 CDF88150.1 - 0.005 16.8 0.0 6.6 7.0 0.0 3.3 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.1 CDF88150.1 - 0.086 13.1 0.0 0.29 11.4 0.0 2.0 1 1 0 1 1 1 0 HEAT repeats DUF3802 PF12290.3 CDF88150.1 - 0.1 12.8 0.1 1.6 9.0 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3802) Acetyltransf_1 PF00583.19 CDF88151.1 - 3.8e-16 58.8 0.3 5.3e-16 58.4 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.1 CDF88151.1 - 1.5e-08 34.7 0.1 1.7e-08 34.5 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CDF88151.1 - 1.6e-08 34.6 0.0 2.1e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 CDF88151.1 - 2.3e-08 34.0 0.2 3.2e-08 33.6 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CDF88151.1 - 8.3e-07 28.6 0.1 1.3e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.1 CDF88151.1 - 0.00021 21.2 0.0 0.00025 20.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 CDF88151.1 - 0.0045 17.1 0.0 0.0049 17.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 CDF88151.1 - 0.03 14.1 0.0 0.035 13.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DnaJ PF00226.26 CDF88152.1 - 2.9e-18 65.3 0.5 7.9e-18 63.9 0.3 1.8 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.11 CDF88152.1 - 4.5e-13 49.1 0.0 2.5e-10 40.0 0.0 2.2 1 1 1 2 2 2 2 Sec63 Brl domain Bd3614_N PF14442.1 CDF88152.1 - 0.0088 16.0 0.5 0.016 15.1 0.3 1.3 1 0 0 1 1 1 1 Bd3614-like deaminase N-terminal DUF2457 PF10446.4 CDF88152.1 - 0.03 13.0 13.9 0.043 12.5 9.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) LEM PF03020.10 CDF88152.1 - 0.03 13.7 0.0 0.067 12.6 0.0 1.6 1 0 0 1 1 1 0 LEM domain RRN3 PF05327.6 CDF88152.1 - 0.5 8.4 4.8 0.83 7.6 3.4 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 NOA36 PF06524.7 CDF88152.1 - 1.5 7.9 9.9 0.24 10.6 4.3 1.5 2 0 0 2 2 2 0 NOA36 protein FAM176 PF14851.1 CDF88152.1 - 4.3 6.9 6.7 9.1 5.9 4.6 1.5 1 0 0 1 1 1 0 FAM176 family Nop14 PF04147.7 CDF88152.1 - 9.3 4.0 15.2 16 3.2 10.5 1.3 1 0 0 1 1 1 0 Nop14-like family Nucleoplasmin PF03066.10 CDF88152.1 - 9.9 5.6 14.8 20 4.6 10.3 1.4 1 0 0 1 1 1 0 Nucleoplasmin TAP_C PF03943.8 CDF88153.1 - 5.8e-16 57.6 0.2 2e-15 55.9 0.0 2.0 2 0 0 2 2 2 1 TAP C-terminal domain LRR_4 PF12799.2 CDF88153.1 - 4.9e-08 32.4 4.5 4.9e-06 26.0 1.0 3.1 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.1 CDF88153.1 - 6.1e-05 22.6 0.5 0.0001 21.9 0.4 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.1 CDF88153.1 - 0.0025 17.7 3.0 1.3 9.3 0.1 3.9 3 0 0 3 3 3 1 Leucine Rich repeat LRR_7 PF13504.1 CDF88153.1 - 0.27 11.5 1.9 7.4 7.2 0.1 3.7 3 0 0 3 3 3 0 Leucine rich repeat LRR_1 PF00560.28 CDF88153.1 - 3.9 7.8 12.4 10 6.5 0.9 5.0 5 1 1 6 6 6 0 Leucine Rich Repeat Cyt-b5 PF00173.23 CDF88155.1 - 1.1e-11 44.3 0.1 1.5e-11 43.8 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TFR_dimer PF04253.10 CDF88156.1 - 2.3e-32 111.2 0.0 4.7e-32 110.1 0.0 1.6 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.12 CDF88156.1 - 6.4e-05 22.7 0.0 0.00012 21.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PIGA PF08288.7 CDF88157.1 - 8.3e-43 144.6 2.3 1.7e-42 143.7 1.0 2.0 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glycos_transf_1 PF00534.15 CDF88157.1 - 1.4e-32 112.5 0.0 2.4e-32 111.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 CDF88157.1 - 3.3e-19 69.2 0.2 6.3e-19 68.3 0.1 1.5 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.1 CDF88157.1 - 3.8e-15 56.2 0.0 9.3e-15 54.9 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 CDF88157.1 - 2e-14 54.0 0.0 2.8e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.1 CDF88157.1 - 0.00015 21.5 0.2 0.00034 20.4 0.2 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.1 CDF88157.1 - 0.0016 18.7 0.0 0.0031 17.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 CAP_GLY PF01302.20 CDF88158.1 - 4.1e-20 71.2 0.5 9.3e-20 70.1 0.3 1.6 1 0 0 1 1 1 1 CAP-Gly domain OKR_DC_1_C PF03711.10 CDF88158.1 - 0.015 15.3 0.0 0.064 13.3 0.0 2.1 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, C-terminal domain Bacillus_HBL PF05791.6 CDF88158.1 - 0.025 13.9 0.7 0.025 13.9 0.5 3.4 2 2 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) KLRAQ PF10205.4 CDF88158.1 - 1.5 8.8 15.4 0.035 14.1 1.2 3.5 3 1 1 4 4 4 0 Predicted coiled-coil domain-containing protein HALZ PF02183.13 CDF88158.1 - 2.4 7.9 15.4 4.5 7.0 0.5 4.6 4 0 0 4 4 4 0 Homeobox associated leucine zipper Reo_sigmaC PF04582.7 CDF88158.1 - 4.4 6.4 7.3 0.91 8.6 1.2 2.4 2 1 0 2 2 2 0 Reovirus sigma C capsid protein PspB PF06667.7 CDF88158.1 - 7.5 6.5 7.6 0.91 9.5 0.3 3.0 3 1 0 3 3 3 0 Phage shock protein B EF-hand_1 PF00036.27 CDF88159.1 - 9.6e-26 87.1 13.2 4.5e-08 31.8 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 CDF88159.1 - 2.2e-25 88.5 11.7 1.7e-14 53.6 1.4 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 CDF88159.1 - 7.6e-23 78.3 10.4 1.9e-07 30.3 0.1 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.1 CDF88159.1 - 3.5e-19 68.1 12.2 2.3e-11 43.1 0.4 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 CDF88159.1 - 8.3e-17 59.6 12.6 3.6e-05 22.9 0.0 4.2 4 1 0 4 4 4 3 EF hand EF-hand_9 PF14658.1 CDF88159.1 - 3.9e-08 33.0 0.6 0.0039 17.0 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.2 CDF88159.1 - 2.1e-07 30.6 4.2 0.0011 18.7 0.1 2.8 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 CDF88159.1 - 0.0024 17.8 1.3 0.31 11.0 0.1 2.2 1 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region VCBS PF13517.1 CDF88159.1 - 0.053 13.8 4.4 0.27 11.6 0.0 2.6 3 0 0 3 3 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella MerR-DNA-bind PF09278.6 CDF88159.1 - 0.058 13.7 1.6 12 6.3 0.1 3.2 3 1 0 3 3 3 0 MerR, DNA binding MgtE_N PF03448.12 CDF88159.1 - 0.061 13.6 0.2 0.061 13.6 0.2 2.3 3 0 0 3 3 3 0 MgtE intracellular N domain Caleosin PF05042.8 CDF88159.1 - 0.092 12.3 0.7 1 8.8 0.0 2.6 1 1 2 3 3 3 0 Caleosin related protein FG-GAP PF01839.18 CDF88159.1 - 7.2 6.4 6.0 7.3 6.4 0.1 2.5 2 0 0 2 2 2 0 FG-GAP repeat Ribonuc_L-PSP PF01042.16 CDF88160.1 - 4.4e-36 123.2 0.1 5.4e-36 123.0 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP MreB_Mbl PF06723.8 CDF88160.1 - 0.047 12.2 0.0 0.05 12.1 0.0 1.1 1 0 0 1 1 1 0 MreB/Mbl protein Ribosomal_S14 PF00253.16 CDF88161.1 - 4.8e-18 64.2 0.3 9e-18 63.4 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e Ras PF00071.17 CDF88162.1 - 6.8e-54 181.6 0.0 8.3e-54 181.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDF88162.1 - 2e-16 60.5 0.0 3.6e-16 59.7 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDF88162.1 - 5.2e-07 29.0 0.0 8.5e-07 28.3 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 CDF88162.1 - 0.0037 16.7 0.0 0.02 14.3 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 CDF88162.1 - 0.0091 15.1 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Kinesin PF00225.18 CDF88163.1 - 8.5e-104 346.8 9.2 8.5e-104 346.8 6.4 3.5 3 1 0 3 3 3 1 Kinesin motor domain Sel1 PF08238.7 CDF88164.1 - 3e-43 145.2 14.2 2.5e-09 37.4 0.3 7.5 7 0 0 7 7 7 7 Sel1 repeat Pro_CA PF00484.14 CDF88166.1 - 2e-34 118.7 0.1 2.6e-34 118.4 0.1 1.1 1 0 0 1 1 1 1 Carbonic anhydrase Glyco_hydro_15 PF00723.16 CDF88167.1 - 2.4e-60 204.3 0.0 3.4e-60 203.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Complex1_LYR_2 PF13233.1 CDF88168.1 - 5.9e-19 68.4 5.2 8.5e-19 67.9 3.6 1.3 1 0 0 1 1 1 1 Complex1_LYR-like HpaB PF03241.8 CDF88168.1 - 0.072 11.9 0.1 0.79 8.5 0.0 2.2 2 0 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase C terminal UPF0172 PF03665.8 CDF88168.1 - 0.11 11.9 2.1 0.14 11.5 1.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) ETF_QO PF05187.8 CDF88168.1 - 0.12 12.3 0.2 0.2 11.6 0.1 1.4 1 1 0 1 1 1 0 Electron transfer flavoprotein-ubiquinone oxidoreductase YebO PF13974.1 CDF88168.1 - 2.1 8.1 5.4 4.9 7.0 3.3 2.1 1 1 1 2 2 2 0 YebO-like protein SNF2_N PF00176.18 CDF88170.1 - 4.6e-68 229.2 0.2 1.1e-67 228.0 0.1 1.7 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CDF88170.1 - 2.5e-12 46.4 0.0 8e-12 44.8 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.1 CDF88170.1 - 0.00015 21.4 8.4 0.00073 19.2 6.0 2.0 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.1 CDF88170.1 - 0.0026 17.5 8.2 0.0059 16.4 5.7 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 CDF88170.1 - 0.0059 16.2 6.9 0.012 15.2 4.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDF88170.1 - 0.0061 16.5 7.6 0.016 15.2 5.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 CDF88170.1 - 0.047 13.4 2.5 0.18 11.5 1.7 2.1 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.20 CDF88170.1 - 0.067 12.8 8.3 0.17 11.6 5.8 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Cellulase PF00150.13 CDF88171.1 - 9.5e-12 44.6 0.4 1.9e-11 43.7 0.2 1.5 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF1708 PF08101.6 CDF88173.1 - 2.5e-153 510.8 7.9 7.4e-153 509.2 5.5 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF1708) RhoGAP PF00620.22 CDF88173.1 - 0.0068 16.0 0.0 0.029 13.9 0.0 2.0 2 0 0 2 2 2 1 RhoGAP domain G_glu_transpept PF01019.16 CDF88174.1 - 1.2e-138 462.8 0.0 1.4e-138 462.5 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase GTP_EFTU PF00009.22 CDF88175.1 - 1.6e-61 207.0 0.2 2.1e-61 206.6 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 CDF88175.1 - 3.7e-28 97.6 0.0 9.3e-28 96.3 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 CDF88175.1 - 1.8e-21 76.0 1.7 4.1e-21 74.8 1.2 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 CDF88175.1 - 1.5e-05 24.5 0.1 3.9e-05 23.2 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 CDF88175.1 - 3.2e-05 23.8 0.0 5.7e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CDF88175.1 - 0.00095 19.6 0.0 0.0017 18.8 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein PduV-EutP PF10662.4 CDF88175.1 - 0.012 15.0 0.4 4.4 6.7 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DisA_N PF02457.11 CDF88175.1 - 0.062 12.4 0.1 0.15 11.1 0.0 1.7 2 0 0 2 2 2 0 DisA bacterial checkpoint controller nucleotide-binding CbiA PF01656.18 CDF88175.1 - 0.12 11.7 2.9 7.7 5.8 0.8 2.3 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain zf-U1 PF06220.7 CDF88176.1 - 4.7e-18 64.4 5.1 8.4e-18 63.6 3.6 1.4 1 0 0 1 1 1 1 U1 zinc finger zf-C2H2_jaz PF12171.3 CDF88176.1 - 0.57 10.3 6.6 2.1 8.6 4.6 2.0 1 1 0 1 1 1 0 Zinc-finger double-stranded RNA-binding IncA PF04156.9 CDF88177.1 - 0.014 15.0 0.0 0.018 14.6 0.0 1.1 1 0 0 1 1 1 0 IncA protein Reticulon PF02453.12 CDF88177.1 - 0.069 12.7 0.0 0.076 12.6 0.0 1.1 1 0 0 1 1 1 0 Reticulon DUP PF00674.13 CDF88178.1 - 5e-06 26.4 1.5 5e-06 26.4 1.0 1.8 2 0 0 2 2 2 1 DUP family EpsG PF14897.1 CDF88178.1 - 0.00038 19.5 0.7 0.00067 18.6 0.5 1.4 1 0 0 1 1 1 1 EpsG family ATP_sub_h PF10775.4 CDF88179.1 - 7.4e-26 89.6 0.5 1e-25 89.2 0.3 1.2 1 0 0 1 1 1 1 ATP synthase complex subunit h DUF3655 PF12379.3 CDF88179.1 - 0.083 12.8 1.9 0.1 12.5 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3655) ADIP PF11559.3 CDF88180.1 - 4e-05 23.5 3.7 0.002 18.0 1.7 2.9 2 1 0 2 2 2 1 Afadin- and alpha -actinin-Binding DUF1640 PF07798.6 CDF88180.1 - 0.013 15.5 4.2 0.019 15.0 2.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) DUF713 PF05218.9 CDF88180.1 - 0.066 12.9 1.5 0.12 12.0 0.1 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF713) Desmo_N PF06771.6 CDF88180.1 - 0.1 12.5 1.6 0.24 11.3 0.3 2.2 1 1 0 2 2 2 0 Viral Desmoplakin N-terminus SIR2 PF02146.12 CDF88180.1 - 0.1 12.3 0.2 0.2 11.3 0.1 1.5 1 1 0 1 1 1 0 Sir2 family DivIC PF04977.10 CDF88180.1 - 0.12 11.8 1.0 23 4.5 0.0 3.2 3 0 0 3 3 3 0 Septum formation initiator NPV_P10 PF05531.7 CDF88180.1 - 0.26 11.5 5.7 3.1 8.1 0.5 3.4 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.6 CDF88180.1 - 0.71 9.7 3.4 4.6 7.1 0.1 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) IncA PF04156.9 CDF88180.1 - 1.6 8.3 7.5 15 5.1 1.0 2.8 2 1 2 4 4 4 0 IncA protein DivIVA PF05103.8 CDF88180.1 - 1.7 8.7 4.8 1.7 8.7 1.7 2.0 2 0 0 2 2 2 0 DivIVA protein zf-H2C2_2 PF13465.1 CDF88181.1 - 5.4e-09 35.8 18.6 2.5e-06 27.5 4.7 3.5 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.21 CDF88181.1 - 1.2e-08 34.7 19.8 1.8e-06 27.9 1.8 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CDF88181.1 - 1.1e-05 25.4 19.4 1.9e-05 24.6 0.7 2.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CDF88181.1 - 0.00031 20.8 9.5 0.049 13.7 2.8 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding PEHE PF15275.1 CDF88181.1 - 0.53 10.7 3.3 0.15 12.4 0.3 1.6 2 0 0 2 2 2 0 PEHE domain zf-C2HC_2 PF13913.1 CDF88181.1 - 0.68 9.6 7.5 1.7 8.4 0.4 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type MHC_I_C PF06623.6 CDF88181.1 - 1.6 8.2 3.5 4.3 6.8 2.4 1.7 2 0 0 2 2 2 0 MHC_I C-terminus zf-BED PF02892.10 CDF88181.1 - 9.4 6.0 11.2 1.7 8.4 0.2 2.4 1 1 1 2 2 2 0 BED zinc finger AMPKBI PF04739.10 CDF88182.1 - 2.5e-32 110.7 1.8 4e-32 110.0 1.3 1.3 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interation domain adh_short PF00106.20 CDF88183.1 - 1.2e-30 106.6 0.1 3.7e-30 105.0 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 CDF88183.1 - 1.3e-17 64.3 0.0 2.6e-17 63.4 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CDF88183.1 - 2.4e-11 43.6 0.0 4.1e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CDF88183.1 - 8.6e-07 28.6 0.1 2.1e-06 27.3 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CDF88183.1 - 2.7e-05 24.2 0.0 4.3e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding RmlD_sub_bind PF04321.12 CDF88183.1 - 0.00035 19.5 0.1 0.00056 18.8 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain DUF1776 PF08643.5 CDF88183.1 - 0.0013 17.9 0.0 0.51 9.4 0.0 2.3 2 1 0 2 2 2 2 Fungal family of unknown function (DUF1776) NmrA PF05368.8 CDF88183.1 - 0.0018 17.5 0.0 0.0043 16.3 0.0 1.6 2 0 0 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.10 CDF88183.1 - 0.034 13.0 0.1 0.051 12.4 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.3 CDF88183.1 - 0.069 12.9 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase SPT16 PF08644.6 CDF88184.1 - 1.8e-50 170.7 0.1 1.8e-50 170.7 0.0 2.3 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.1 CDF88184.1 - 1.7e-46 157.7 0.7 1.7e-46 157.7 0.5 2.4 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.19 CDF88184.1 - 3.9e-24 85.3 0.0 6e-24 84.7 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.7 CDF88184.1 - 7e-19 67.6 0.3 3e-18 65.5 0.1 2.3 2 0 0 2 2 2 1 Histone chaperone Rttp106-like Clathrin PF00637.15 CDF88185.1 - 2.9e-194 636.4 59.8 6.4e-34 116.6 2.3 8.5 9 0 0 9 9 9 7 Region in Clathrin and VPS Clathrin_H_link PF13838.1 CDF88185.1 - 9.5e-25 86.2 0.3 3.8e-24 84.3 0.2 2.2 1 0 0 1 1 1 1 Clathrin-H-link Clathrin_propel PF01394.15 CDF88185.1 - 1.1e-16 59.8 5.2 0.00011 22.2 0.2 5.8 5 0 0 5 5 5 4 Clathrin propeller repeat Clathrin-link PF09268.5 CDF88185.1 - 3.5e-10 38.7 0.4 8.9e-10 37.3 0.2 1.8 1 0 0 1 1 1 1 Clathrin, heavy-chain linker ACOX PF01756.14 CDF88186.1 - 3.9e-45 153.5 0.0 7.1e-45 152.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.14 CDF88186.1 - 1.7e-14 53.0 0.4 3.6e-14 51.9 0.3 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.1 CDF88186.1 - 1.1e-12 48.3 0.1 6.3e-12 45.8 0.1 2.1 1 1 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.19 CDF88186.1 - 0.0016 18.5 0.0 0.038 14.1 0.0 2.3 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain DUF190 PF02641.10 CDF88186.1 - 0.14 12.0 0.0 0.38 10.6 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized ACR, COG1993 RabGAP-TBC PF00566.13 CDF88187.1 - 1.7e-49 168.1 0.5 1.7e-49 168.1 0.4 3.4 3 1 1 4 4 4 1 Rab-GTPase-TBC domain IncA PF04156.9 CDF88187.1 - 0.043 13.4 10.9 0.52 9.8 5.8 2.6 2 0 0 2 2 2 0 IncA protein CENP-F_leu_zip PF10473.4 CDF88187.1 - 0.3 10.9 16.0 0.25 11.1 6.4 2.6 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Pox_A_type_inc PF04508.7 CDF88187.1 - 0.5 10.2 7.8 7.4 6.6 0.2 3.5 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Nup54 PF13874.1 CDF88187.1 - 4 7.0 12.5 7.8 6.1 4.1 3.0 3 0 0 3 3 3 0 Nucleoporin complex subunit 54 Fungal_trans PF04082.13 CDF88189.1 - 4.4e-30 104.4 3.1 7.3e-30 103.7 2.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Gal4_dimer PF03902.8 CDF88189.1 - 7.1e-13 48.2 0.3 1.6e-12 47.1 0.2 1.6 1 0 0 1 1 1 1 Gal4-like dimerisation domain Zn_clus PF00172.13 CDF88189.1 - 1.9e-07 30.8 17.3 1.9e-07 30.8 12.0 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain YvrJ PF12841.2 CDF88189.1 - 2.6 7.4 5.3 1.2 8.4 0.2 2.5 2 0 0 2 2 2 0 YvrJ protein family RQC PF09382.5 CDF88190.1 - 4.3e-26 90.6 0.2 9.9e-26 89.5 0.1 1.6 1 0 0 1 1 1 1 RQC domain Helicase_Sgs1 PF11408.3 CDF88190.1 - 1.4e-24 85.7 0.0 4.5e-24 84.0 0.0 2.0 1 0 0 1 1 1 1 Sgs1 RecQ helicase DEAD PF00270.24 CDF88190.1 - 5.5e-22 78.0 2.6 6e-21 74.6 0.0 3.0 4 0 0 4 4 4 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF88190.1 - 5.5e-21 74.2 0.1 5.5e-19 67.8 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain MFS_1 PF07690.11 CDF88191.1 - 7.4e-18 64.3 17.2 9e-17 60.8 10.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily GDC-P PF02347.11 CDF88192.1 - 4.6e-192 638.4 0.0 1.2e-179 597.5 0.0 2.6 3 0 0 3 3 3 2 Glycine cleavage system P-protein Beta_elim_lyase PF01212.16 CDF88192.1 - 1.5e-06 27.6 0.1 0.00024 20.3 0.0 2.2 2 0 0 2 2 2 2 Beta-eliminating lyase Aminotran_5 PF00266.14 CDF88192.1 - 0.00024 19.9 0.0 0.00059 18.6 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class-V WD40 PF00400.27 CDF88193.1 - 2.4e-23 81.0 10.9 5.5e-09 35.5 0.1 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat Ribosomal_S17 PF00366.15 CDF88194.1 - 2.6e-15 56.1 0.1 5.8e-15 55.0 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein S17 YlbD_coat PF14071.1 CDF88194.1 - 0.015 15.3 0.8 0.015 15.3 0.6 1.6 2 0 0 2 2 2 0 Putative coat protein Spectrin PF00435.16 CDF88194.1 - 0.036 14.3 1.4 0.036 14.3 0.9 1.7 2 0 0 2 2 2 0 Spectrin repeat DUF3347 PF11827.3 CDF88194.1 - 0.27 11.2 1.8 0.42 10.5 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) Rhomboid PF01694.17 CDF88195.1 - 4.5e-20 72.1 9.6 1e-19 70.9 6.6 1.6 1 0 0 1 1 1 1 Rhomboid family DUF1129 PF06570.6 CDF88195.1 - 0.036 13.3 0.7 0.055 12.7 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) DUF2075 PF09848.4 CDF88196.1 - 3.8e-105 351.7 0.0 4.5e-105 351.4 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.1 CDF88196.1 - 4.1e-08 33.4 0.0 2.2e-07 31.0 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDF88196.1 - 8e-06 25.9 0.0 1.8e-05 24.8 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.24 CDF88196.1 - 8.7e-05 22.7 0.0 0.0002 21.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.1 CDF88196.1 - 0.00045 19.8 0.1 0.0039 16.7 0.1 2.2 1 1 0 1 1 1 1 AAA domain PIF1 PF05970.9 CDF88196.1 - 0.00049 19.1 0.0 0.00075 18.5 0.0 1.4 1 0 0 1 1 1 1 PIF1-like helicase ResIII PF04851.10 CDF88196.1 - 0.0013 18.5 0.1 0.3 10.8 0.0 2.3 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit Bac_DnaA PF00308.13 CDF88196.1 - 0.002 17.7 0.4 0.14 11.7 0.2 2.4 1 1 1 2 2 2 1 Bacterial dnaA protein T2SE PF00437.15 CDF88196.1 - 0.0027 16.6 0.1 0.0052 15.7 0.1 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein NACHT PF05729.7 CDF88196.1 - 0.0057 16.3 0.0 0.013 15.1 0.0 1.8 1 1 0 1 1 1 1 NACHT domain AAA_14 PF13173.1 CDF88196.1 - 0.0089 15.9 0.2 0.028 14.3 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CDF88196.1 - 0.018 14.7 0.0 0.056 13.2 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain DUF2216 PF10226.4 CDF88196.1 - 0.02 14.4 0.0 0.039 13.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved proteins (DUF2216) Calcipressin PF04847.7 CDF88196.1 - 0.03 13.8 0.0 0.049 13.2 0.0 1.3 1 0 0 1 1 1 0 Calcipressin RNA_helicase PF00910.17 CDF88196.1 - 0.034 14.3 0.0 0.13 12.4 0.0 2.1 1 0 0 1 1 1 0 RNA helicase DAP3 PF10236.4 CDF88196.1 - 0.036 13.0 0.3 0.082 11.8 0.2 1.8 1 1 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 DUF258 PF03193.11 CDF88196.1 - 0.04 13.1 0.3 0.091 11.9 0.1 1.6 1 1 1 2 2 2 0 Protein of unknown function, DUF258 NB-ARC PF00931.17 CDF88196.1 - 0.048 12.5 0.0 0.088 11.6 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain Arch_ATPase PF01637.13 CDF88196.1 - 0.087 12.5 0.6 0.28 10.8 0.4 1.8 1 1 0 1 1 1 0 Archaeal ATPase Sigma54_activat PF00158.21 CDF88196.1 - 0.094 12.1 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_18 PF13238.1 CDF88196.1 - 0.098 12.9 0.1 1.6 9.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.1 CDF88196.1 - 0.12 11.9 0.7 2.7 7.4 0.0 2.2 1 1 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.18 CDF88196.1 - 0.13 12.2 0.7 0.33 10.9 0.5 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase UAA PF08449.6 CDF88197.1 - 1.3e-76 257.4 12.8 1.5e-76 257.2 8.9 1.0 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.11 CDF88197.1 - 1.8e-09 37.4 8.6 1.8e-09 37.4 5.9 2.4 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 CDF88197.1 - 2e-07 31.0 16.5 2.3e-07 30.9 4.5 2.9 2 1 0 2 2 2 2 EamA-like transporter family EmrE PF13536.1 CDF88197.1 - 0.14 12.3 24.8 0.096 12.8 6.4 3.4 2 1 1 3 3 3 0 Multidrug resistance efflux transporter DUF1104 PF06518.6 CDF88198.1 - 7.5 6.7 9.8 0.8 9.8 0.7 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1104) RINGv PF12906.2 CDF88199.1 - 0.0036 17.3 6.1 0.0036 17.3 4.2 2.0 2 0 0 2 2 2 1 RING-variant domain FANCL_C PF11793.3 CDF88199.1 - 8.1 6.4 15.5 5.7 6.9 0.0 2.8 3 0 0 3 3 3 0 FANCL C-terminal domain RasGAP_C PF03836.10 CDF88200.1 - 1.9e-25 89.2 9.0 6.1e-25 87.5 6.2 2.0 1 0 0 1 1 1 1 RasGAP C-terminus RasGAP PF00616.14 CDF88200.1 - 4.5e-22 78.6 1.7 4.5e-22 78.6 1.2 2.5 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase CH PF00307.26 CDF88200.1 - 1.5e-09 37.8 0.6 3.8e-08 33.3 0.0 2.8 2 0 0 2 2 2 1 Calponin homology (CH) domain IQ PF00612.22 CDF88200.1 - 1.9e-08 33.2 19.6 1 9.1 0.2 9.5 10 0 0 10 10 10 4 IQ calmodulin-binding motif Trypan_PARP PF05887.6 CDF88200.1 - 0.43 10.3 5.0 0.83 9.4 3.5 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) TBCC PF07986.7 CDF88201.1 - 2.2e-05 23.8 6.6 0.00025 20.4 3.7 2.2 1 1 1 2 2 2 2 Tubulin binding cofactor C Carbpep_Y_N PF05388.6 CDF88201.1 - 0.021 14.9 0.1 0.04 14.0 0.0 1.5 1 0 0 1 1 1 0 Carboxypeptidase Y pro-peptide DUF2435 PF10363.4 CDF88203.1 - 6.7e-20 70.7 0.0 4.6e-19 68.1 0.0 2.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2435) DUF2411 PF10304.4 CDF88203.1 - 0.0011 18.4 0.4 0.0044 16.5 0.2 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2411) Ank_4 PF13637.1 CDF88204.1 - 4.5e-18 65.2 0.2 3.9e-12 46.3 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.25 CDF88204.1 - 4.8e-17 60.8 0.6 2e-07 30.4 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.1 CDF88204.1 - 6.6e-17 61.1 0.7 1.1e-08 35.0 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 CDF88204.1 - 3.5e-15 56.1 0.1 7.4e-15 55.0 0.1 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.1 CDF88204.1 - 9.5e-14 50.1 0.1 2.8e-06 27.0 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeat eIF-5_eIF-2B PF01873.12 CDF88205.1 - 1.2e-45 154.2 0.1 1.8e-45 153.5 0.1 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Cob_adeno_trans PF01923.13 CDF88205.1 - 0.0032 17.2 0.4 0.0092 15.7 0.1 1.9 1 1 1 2 2 2 1 Cobalamin adenosyltransferase IF2_N PF04760.10 CDF88205.1 - 0.023 14.3 4.3 0.11 12.1 0.0 3.3 3 1 0 3 3 3 0 Translation initiation factor IF-2, N-terminal region TF_Zn_Ribbon PF08271.7 CDF88205.1 - 0.11 11.7 0.1 0.23 10.7 0.1 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding CCT_2 PF09425.5 CDF88206.1 - 8 6.1 7.3 6.6 6.3 0.0 3.1 4 0 0 4 4 4 0 Divergent CCT motif Pkinase PF00069.20 CDF88207.1 - 1.4e-38 132.5 0.0 6.7e-28 97.5 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDF88207.1 - 4.7e-18 65.1 0.0 3.8e-17 62.2 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CDF88207.1 - 0.0015 18.3 0.0 0.0029 17.3 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.1 CDF88207.1 - 0.0033 16.4 0.0 0.0056 15.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like TIP49 PF06068.8 CDF88208.1 - 4.6e-179 595.2 5.1 5.4e-179 595.0 3.5 1.0 1 0 0 1 1 1 1 TIP49 C-terminus AAA PF00004.24 CDF88208.1 - 6.1e-08 32.9 1.0 9.2e-05 22.6 0.1 2.8 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 CDF88208.1 - 4.2e-07 29.2 3.3 0.00026 20.0 0.0 2.8 2 1 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus DnaB_C PF03796.10 CDF88208.1 - 5.5e-06 25.4 0.1 1e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_22 PF13401.1 CDF88208.1 - 0.00026 21.1 0.1 0.083 13.0 0.0 2.5 1 1 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 CDF88208.1 - 0.0012 18.0 1.0 0.022 13.9 0.2 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.1 CDF88208.1 - 0.0015 18.5 0.0 0.015 15.3 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.1 CDF88208.1 - 0.0046 16.8 0.1 2.3 8.1 0.0 2.8 3 0 0 3 3 3 2 AAA domain AAA_5 PF07728.9 CDF88208.1 - 0.0054 16.4 0.4 1.1 8.9 0.0 2.9 2 2 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.1 CDF88208.1 - 0.03 14.2 0.1 0.12 12.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.1 CDF88208.1 - 0.034 13.5 0.2 0.069 12.5 0.2 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 CDF88208.1 - 0.04 13.0 0.3 0.075 12.1 0.2 1.4 1 0 0 1 1 1 0 Zeta toxin ATP-synt_C PF00137.16 CDF88209.1 - 8.7e-28 96.0 26.1 2.4e-15 56.1 3.0 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Polysacc_synt_3 PF13440.1 CDF88209.1 - 0.0087 15.5 1.0 0.0087 15.5 0.7 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein DUF2686 PF10887.3 CDF88209.1 - 0.099 11.3 0.1 0.12 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2686) Mis14 PF08641.7 CDF88210.1 - 1.2e-20 73.9 1.7 2e-20 73.2 1.2 1.3 1 0 0 1 1 1 1 Kinetochore protein Mis14 like Nnf1 PF03980.9 CDF88210.1 - 0.0089 16.0 5.5 0.0098 15.8 2.9 1.8 2 0 0 2 2 2 1 Nnf1 Sec8_exocyst PF04048.9 CDF88210.1 - 0.035 13.7 1.4 0.13 11.8 0.3 2.0 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain Rgp1 PF08737.5 CDF88210.1 - 0.038 13.0 1.6 0.048 12.7 1.1 1.1 1 0 0 1 1 1 0 Rgp1 GrpE PF01025.14 CDF88210.1 - 0.096 12.2 2.1 0.15 11.5 1.2 1.6 1 1 0 1 1 1 0 GrpE Cor1 PF04803.7 CDF88210.1 - 0.1 12.3 0.9 0.46 10.2 0.2 2.0 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region TPR_MLP1_2 PF07926.7 CDF88210.1 - 0.11 12.2 5.1 0.15 11.8 3.1 1.6 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Sec2p PF06428.6 CDF88210.1 - 0.15 11.9 3.4 1.1 9.1 0.1 2.4 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p IncA PF04156.9 CDF88210.1 - 4.3 6.8 9.0 7.6 6.0 6.0 1.5 1 1 1 2 2 2 0 IncA protein SNARE PF05739.14 CDF88211.1 - 1.4e-17 63.1 8.4 1.4e-17 63.1 5.9 2.6 4 0 0 4 4 2 1 SNARE domain Syntaxin PF00804.20 CDF88211.1 - 2.4e-09 37.2 3.0 2.4e-09 37.2 2.0 2.5 2 1 0 2 2 2 1 Syntaxin Synaptobrevin PF00957.16 CDF88211.1 - 0.0004 19.9 3.0 0.0004 19.9 2.1 2.1 2 1 0 2 2 2 1 Synaptobrevin T2SF PF00482.18 CDF88211.1 - 0.0017 18.2 0.1 0.0045 16.9 0.1 1.7 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein F BLOC1_2 PF10046.4 CDF88211.1 - 0.0028 17.7 8.3 0.053 13.6 0.0 2.9 3 1 0 3 3 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Baculo_PEP_C PF04513.7 CDF88211.1 - 0.0061 16.3 8.0 0.16 11.8 0.4 2.3 2 0 0 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus Rifin_STEVOR PF02009.11 CDF88211.1 - 0.0062 16.2 7.6 0.016 14.8 5.0 1.7 1 1 1 2 2 2 1 Rifin/stevor family AATase PF07247.7 CDF88211.1 - 0.019 13.5 3.4 0.066 11.7 0.1 2.1 2 0 0 2 2 2 0 Alcohol acetyltransferase MMPL PF03176.10 CDF88211.1 - 0.024 13.3 1.1 0.035 12.8 0.8 1.5 1 1 0 1 1 1 0 MMPL family PBP1_TM PF14812.1 CDF88211.1 - 0.074 13.3 0.2 0.074 13.3 0.1 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3753 PF12575.3 CDF88211.1 - 0.26 11.0 1.4 0.65 9.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3753) DUF3708 PF12501.3 CDF88211.1 - 0.31 10.8 6.1 0.97 9.2 0.8 2.7 1 1 1 2 2 2 0 Phosphate ATP-binding cassette transporter DUF848 PF05852.6 CDF88211.1 - 0.34 10.7 10.1 0.42 10.4 2.1 2.3 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) FliT PF05400.8 CDF88211.1 - 1.2 9.6 16.0 0.51 10.7 1.6 2.9 2 2 1 3 3 3 0 Flagellar protein FliT Allexi_40kDa PF05549.6 CDF88211.1 - 1.4 8.1 6.4 2.7 7.2 0.4 2.1 2 0 0 2 2 2 0 Allexivirus 40kDa protein DUF2562 PF10814.3 CDF88211.1 - 1.5 8.7 6.2 2 8.3 2.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2562) Fib_alpha PF08702.5 CDF88211.1 - 2.3 8.3 15.8 2.7 8.0 1.9 2.9 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF3810 PF12725.2 CDF88211.1 - 2.3 7.0 7.9 6.8 5.4 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3810) DUF912 PF06024.7 CDF88211.1 - 3.3 7.8 6.6 0.3 11.1 0.5 2.2 2 1 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) DUF4094 PF13334.1 CDF88211.1 - 3.3 8.1 6.5 0.45 10.9 0.1 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4094) DUF883 PF05957.8 CDF88211.1 - 4 7.9 10.8 2.3 8.6 0.7 3.3 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF883) GrpE PF01025.14 CDF88211.1 - 4.9 6.6 16.0 3 7.3 1.7 2.6 2 1 0 2 2 2 0 GrpE DUF1664 PF07889.7 CDF88211.1 - 4.9 6.9 9.8 1.6 8.5 2.6 2.8 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) SlyX PF04102.7 CDF88211.1 - 6.1 7.2 12.1 0.17 12.2 2.7 2.4 2 1 0 2 2 2 0 SlyX Sigma_reg_N PF13800.1 CDF88211.1 - 7.3 6.7 6.1 5.5 7.0 1.9 2.3 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF2203 PF09969.4 CDF88211.1 - 9 6.5 11.7 1 9.5 1.7 2.8 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Syntaxin_2 PF14523.1 CDF88211.1 - 9.4 6.3 14.6 0.68 9.9 4.3 2.4 2 1 0 2 2 2 0 Syntaxin-like protein adh_short PF00106.20 CDF88212.1 - 3.9e-15 56.1 0.0 4.9e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CDF88212.1 - 2.7e-09 37.1 0.0 3.3e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CDF88212.1 - 2.3e-07 30.6 0.0 2.9e-07 30.3 0.0 1.3 1 1 0 1 1 1 1 KR domain Epimerase PF01370.16 CDF88212.1 - 0.0029 17.0 0.0 0.0083 15.5 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family ABC2_membrane PF01061.19 CDF88213.1 - 2.5e-64 216.3 59.5 6.6e-39 133.2 10.0 2.8 3 0 0 3 3 3 2 ABC-2 type transporter PDR_CDR PF06422.7 CDF88213.1 - 7.7e-37 125.0 6.3 1.7e-31 107.9 0.0 3.1 3 0 0 3 3 2 2 CDR ABC transporter ABC_tran PF00005.22 CDF88213.1 - 9.8e-37 126.3 0.0 7.2e-18 65.2 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_trans_N PF14510.1 CDF88213.1 - 4.7e-12 45.8 0.0 1.8e-11 43.9 0.0 2.0 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal ABC2_membrane_3 PF12698.2 CDF88213.1 - 3.9e-07 29.4 13.4 3.9e-07 29.4 9.3 3.3 2 2 0 2 2 2 1 ABC-2 family transporter protein AAA_25 PF13481.1 CDF88213.1 - 3.6e-06 26.4 0.1 0.0038 16.6 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_21 PF13304.1 CDF88213.1 - 0.00011 22.3 0.0 0.57 10.0 0.0 3.8 4 0 0 4 4 3 1 AAA domain DUF258 PF03193.11 CDF88213.1 - 0.00013 21.1 0.1 0.00045 19.4 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function, DUF258 cobW PF02492.14 CDF88213.1 - 0.00037 19.9 0.0 0.00093 18.6 0.0 1.7 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.1 CDF88213.1 - 0.00069 19.0 0.5 0.033 13.7 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.1 CDF88213.1 - 0.00074 19.6 0.2 0.0091 16.1 0.0 2.6 3 0 0 3 3 2 1 AAA domain AAA_16 PF13191.1 CDF88213.1 - 0.001 19.0 3.3 0.072 13.0 0.5 3.3 3 1 0 3 3 3 1 AAA ATPase domain SMC_N PF02463.14 CDF88213.1 - 0.004 16.4 0.0 0.53 9.4 0.0 3.1 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain Miro PF08477.8 CDF88213.1 - 0.0062 17.0 0.0 4.5 7.7 0.0 3.1 3 0 0 3 3 2 1 Miro-like protein FtsK_SpoIIIE PF01580.13 CDF88213.1 - 0.0083 15.6 0.3 2.3 7.6 0.0 2.5 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_18 PF13238.1 CDF88213.1 - 0.014 15.7 0.7 0.11 12.7 0.0 2.7 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.1 CDF88213.1 - 0.016 15.0 0.6 0.11 12.3 0.0 2.6 3 0 0 3 3 2 0 AAA domain AAA_17 PF13207.1 CDF88213.1 - 0.019 15.7 0.3 0.095 13.5 0.0 2.4 3 0 0 3 3 1 0 AAA domain UPF0079 PF02367.12 CDF88213.1 - 0.03 13.9 0.7 0.19 11.3 0.1 2.3 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 MMR_HSR1 PF01926.18 CDF88213.1 - 0.038 13.9 0.1 0.56 10.1 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase RNA_helicase PF00910.17 CDF88213.1 - 0.052 13.7 0.0 3.1 8.0 0.0 2.8 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.1 CDF88213.1 - 0.072 13.0 0.1 0.25 11.2 0.1 1.9 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.1 CDF88213.1 - 0.083 11.9 0.0 0.15 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.7 CDF88213.1 - 0.097 12.3 0.5 0.5 10.0 0.1 2.3 2 0 0 2 2 2 0 NACHT domain Dynamin_N PF00350.18 CDF88213.1 - 0.098 12.4 0.2 0.32 10.7 0.0 1.9 2 0 0 2 2 2 0 Dynamin family AAA_24 PF13479.1 CDF88213.1 - 0.12 11.9 0.5 1.5 8.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.1 CDF88213.1 - 0.22 11.0 0.7 5.6 6.4 0.1 2.7 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.1 CDF88213.1 - 2.7 7.8 4.1 9.9 5.9 0.2 3.0 3 0 0 3 3 3 0 Part of AAA domain FMN_bind_2 PF04299.7 CDF88214.1 - 2.1e-56 190.0 0.0 2.6e-56 189.7 0.0 1.1 1 0 0 1 1 1 1 Putative FMN-binding domain ketoacyl-synt PF00109.21 CDF88215.1 - 2.3e-18 66.6 0.0 4.5e-18 65.6 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain adh_short_C2 PF13561.1 CDF88215.1 - 2.3e-18 66.8 0.0 6.2e-18 65.4 0.0 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase ACPS PF01648.15 CDF88215.1 - 3.9e-18 65.3 0.0 8.4e-18 64.2 0.0 1.6 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.17 CDF88215.1 - 1.8e-12 47.1 0.0 7.2e-12 45.2 0.0 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.20 CDF88215.1 - 2.1e-06 27.7 0.0 5.3e-06 26.4 0.0 1.8 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CDF88215.1 - 0.00026 20.7 0.0 0.00069 19.3 0.0 1.7 1 0 0 1 1 1 1 KR domain HSP20 PF00011.16 CDF88216.1 - 6.3e-20 70.9 0.3 1.1e-19 70.1 0.2 1.4 1 0 0 1 1 1 1 Hsp20/alpha crystallin family DUF4452 PF14618.1 CDF88217.1 - 2.1 8.1 7.8 0.8 9.5 0.5 2.7 1 1 1 3 3 3 0 Domain of unknown function (DUF4452) mRNA_triPase PF02940.10 CDF88218.1 - 1.4e-54 185.1 0.1 2.3e-54 184.4 0.1 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain Glycos_transf_2 PF00535.21 CDF88219.1 - 5.8e-23 81.4 0.0 7.9e-23 80.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 CDF88219.1 - 4.2e-08 33.2 0.0 9.4e-08 32.1 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.1 CDF88219.1 - 0.042 14.1 0.0 0.077 13.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 ABC_tran PF00005.22 CDF88221.1 - 2.3e-48 163.9 0.0 4.8e-25 88.4 0.0 3.8 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 CDF88221.1 - 2.9e-17 63.5 5.2 1e-07 32.2 0.1 3.9 2 2 1 3 3 3 3 AAA domain SMC_N PF02463.14 CDF88221.1 - 1.8e-12 46.9 0.0 0.0011 18.2 0.0 4.1 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 CDF88221.1 - 3.7e-08 32.7 0.2 0.011 15.2 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.1 CDF88221.1 - 1.3e-07 32.2 2.7 0.0084 16.4 0.1 3.6 3 0 0 3 3 3 2 AAA domain Chromo PF00385.19 CDF88221.1 - 5.9e-07 29.0 1.5 1.4e-06 27.8 1.0 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DUF258 PF03193.11 CDF88221.1 - 1e-06 28.0 0.0 0.0074 15.4 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_17 PF13207.1 CDF88221.1 - 3.6e-06 27.7 0.3 0.1 13.3 0.0 3.2 2 1 0 2 2 2 2 AAA domain AAA_10 PF12846.2 CDF88221.1 - 4.3e-06 26.3 0.0 0.7 9.2 0.0 4.6 4 1 0 4 4 4 2 AAA-like domain MMR_HSR1 PF01926.18 CDF88221.1 - 7e-06 25.9 0.0 0.098 12.6 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase Miro PF08477.8 CDF88221.1 - 2.6e-05 24.6 0.0 0.12 12.9 0.0 2.8 2 0 0 2 2 2 2 Miro-like protein AAA_15 PF13175.1 CDF88221.1 - 7.2e-05 22.0 5.9 0.25 10.3 0.0 4.3 4 1 0 5 5 5 2 AAA ATPase domain AAA_22 PF13401.1 CDF88221.1 - 0.00017 21.7 0.0 0.62 10.2 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.1 CDF88221.1 - 0.0002 21.3 0.1 0.35 10.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.18 CDF88221.1 - 0.00025 20.9 0.2 0.08 12.7 0.0 3.6 2 1 0 3 3 3 1 Dynamin family DUF87 PF01935.12 CDF88221.1 - 0.00026 20.8 1.7 0.091 12.5 0.0 3.7 3 0 0 3 3 3 1 Domain of unknown function DUF87 ArgK PF03308.11 CDF88221.1 - 0.00038 19.3 0.1 0.46 9.2 0.0 2.4 2 0 0 2 2 2 2 ArgK protein MobB PF03205.9 CDF88221.1 - 0.00045 19.9 0.1 0.15 11.7 0.0 3.3 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 CDF88221.1 - 0.00053 20.3 0.2 0.4 10.9 0.0 3.0 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 CDF88221.1 - 0.00072 19.7 0.2 2 8.5 0.0 3.4 3 0 0 3 3 2 1 RNA helicase AAA_33 PF13671.1 CDF88221.1 - 0.00075 19.4 0.0 0.41 10.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.1 CDF88221.1 - 0.00094 18.8 0.3 0.8 9.2 0.1 2.9 2 1 0 2 2 2 1 AAA domain SbcCD_C PF13558.1 CDF88221.1 - 0.0026 17.6 3.0 1.3 9.0 0.0 4.0 3 2 1 4 4 3 1 Putative exonuclease SbcCD, C subunit NACHT PF05729.7 CDF88221.1 - 0.0027 17.3 0.2 3.3 7.3 0.0 2.8 2 1 0 2 2 2 1 NACHT domain Arch_ATPase PF01637.13 CDF88221.1 - 0.0045 16.7 0.1 3.3 7.3 0.0 2.6 2 0 0 2 2 2 1 Archaeal ATPase DUF815 PF05673.8 CDF88221.1 - 0.01 14.8 0.1 1.9 7.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA PF00004.24 CDF88221.1 - 0.013 15.7 0.0 4.2 7.5 0.0 2.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 CDF88221.1 - 0.013 15.3 0.2 2.4 8.0 0.0 3.2 3 1 0 3 3 2 0 AAA domain Zeta_toxin PF06414.7 CDF88221.1 - 0.014 14.4 0.0 9.8 5.2 0.0 3.3 4 0 0 4 4 3 0 Zeta toxin HEAT PF02985.17 CDF88221.1 - 0.019 14.9 0.3 14 6.0 0.0 3.5 3 0 0 3 3 2 0 HEAT repeat AAA_16 PF13191.1 CDF88221.1 - 0.035 14.0 0.0 2.1 8.3 0.0 3.1 2 0 0 2 2 2 0 AAA ATPase domain FtsK_SpoIIIE PF01580.13 CDF88221.1 - 0.038 13.4 0.3 3.1 7.2 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family PduV-EutP PF10662.4 CDF88221.1 - 0.071 12.6 0.1 9.4 5.7 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.14 CDF88221.1 - 0.089 12.2 0.0 24 4.2 0.0 3.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Ipi1_N PF12333.3 CDF88221.1 - 0.11 12.5 0.0 3.9 7.4 0.0 2.8 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation AAA_25 PF13481.1 CDF88221.1 - 0.12 11.7 0.0 16 4.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain PAP1 PF08601.5 CDF88221.1 - 0.17 11.5 8.2 0.34 10.5 5.7 1.4 1 0 0 1 1 1 0 Transcription factor PAP1 ABC_ATPase PF09818.4 CDF88221.1 - 0.55 8.7 3.3 0.74 8.3 0.0 2.7 3 1 0 3 3 3 0 Predicted ATPase of the ABC class Thymidylate_kin PF02223.12 CDF88221.1 - 7.2 5.9 8.1 0.64 9.3 0.0 3.0 4 0 0 4 4 3 0 Thymidylate kinase MoCF_biosynth PF00994.19 CDF88222.1 - 6.1e-33 113.2 0.0 9.3e-33 112.6 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain Polysacc_synt_4 PF04669.8 CDF88223.1 - 1.7e-24 86.2 3.7 1.1e-23 83.6 2.6 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis Cullin_binding PF03556.10 CDF88223.1 - 0.012 15.7 0.5 0.025 14.7 0.3 1.5 1 0 0 1 1 1 0 Cullin binding SUV3_C PF12513.3 CDF88223.1 - 0.095 12.1 0.1 0.24 10.8 0.0 1.7 1 0 0 1 1 1 0 Mitochondrial degradasome RNA helicase subunit C terminal Cation_efflux PF01545.16 CDF88224.1 - 8.2e-41 139.9 2.7 1.1e-40 139.5 1.9 1.1 1 0 0 1 1 1 1 Cation efflux family ARID PF01388.16 CDF88225.1 - 8.3e-25 86.4 0.0 3.5e-24 84.4 0.0 2.2 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjC PF02373.17 CDF88225.1 - 4e-20 72.1 0.0 1.3e-11 44.7 0.0 2.7 2 0 0 2 2 2 2 JmjC domain, hydroxylase PLU-1 PF08429.6 CDF88225.1 - 6.1e-10 38.5 3.4 1.2e-09 37.5 2.3 1.5 1 0 0 1 1 1 1 PLU-1-like protein PHD PF00628.24 CDF88225.1 - 6.7e-08 32.1 7.9 6.7e-08 32.1 5.5 1.9 2 0 0 2 2 2 1 PHD-finger JmjN PF02375.12 CDF88225.1 - 9.2e-07 28.2 0.0 2.1e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 jmjN domain zf-HC5HC2H PF13771.1 CDF88225.1 - 0.015 15.4 2.5 0.065 13.3 1.8 2.1 1 0 0 1 1 1 0 PHD-like zinc-binding domain C1_1 PF00130.17 CDF88225.1 - 0.027 14.2 1.9 0.12 12.0 1.3 2.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) CARD PF00619.16 CDF88226.1 - 0.0077 16.0 0.0 0.0085 15.9 0.0 1.1 1 0 0 1 1 1 1 Caspase recruitment domain Inhibitor_I34 PF10466.4 CDF88226.1 - 0.077 13.0 0.1 0.11 12.5 0.1 1.6 1 1 0 1 1 1 0 Saccharopepsin inhibitor I34 GCR1_C PF12550.3 CDF88228.1 - 2.4e-24 84.9 0.3 5.6e-24 83.8 0.2 1.7 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes BSP_II PF05432.6 CDF88228.1 - 0.0085 15.4 11.0 0.0085 15.4 7.6 2.4 3 0 0 3 3 3 1 Bone sialoprotein II (BSP-II) CDC45 PF02724.9 CDF88228.1 - 3.7 5.4 20.8 0.085 10.8 8.0 2.0 2 0 0 2 2 2 0 CDC45-like protein SlyX PF04102.7 CDF88228.1 - 5.1 7.5 11.4 0.1 12.9 1.1 2.7 2 0 0 2 2 2 0 SlyX UPF0061 PF02696.9 CDF88229.1 - 3.9e-145 483.8 0.1 4.6e-145 483.6 0.1 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family Lon_C PF05362.8 CDF88230.1 - 1.8e-45 154.8 0.1 3e-45 154.0 0.0 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.24 CDF88230.1 - 1.3e-19 70.6 0.0 7.4e-19 68.2 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) LON PF02190.11 CDF88230.1 - 1.5e-07 31.2 1.4 2.2e-07 30.7 0.1 1.9 2 0 0 2 2 2 1 ATP-dependent protease La (LON) domain ChlI PF13541.1 CDF88230.1 - 1.2e-06 28.0 0.1 2.4e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.9 CDF88230.1 - 5.1e-06 26.2 0.0 1.8e-05 24.5 0.0 2.0 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 CDF88230.1 - 7.2e-05 22.8 0.2 0.00021 21.3 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_PrkA PF08298.6 CDF88230.1 - 0.00014 20.6 0.4 0.00032 19.5 0.0 1.7 2 0 0 2 2 2 1 PrkA AAA domain AAA_2 PF07724.9 CDF88230.1 - 0.00021 21.2 0.0 0.0017 18.2 0.0 2.4 2 1 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_17 PF13207.1 CDF88230.1 - 0.00022 22.0 0.1 0.0011 19.7 0.0 2.3 2 0 0 2 2 1 1 AAA domain AAA_22 PF13401.1 CDF88230.1 - 0.00043 20.4 0.0 0.011 15.9 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA_3 PF07726.6 CDF88230.1 - 0.00049 19.7 0.0 0.0012 18.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.17 CDF88230.1 - 0.0018 17.1 0.4 0.011 14.6 0.0 2.1 2 0 0 2 2 2 1 NB-ARC domain RuvB_N PF05496.7 CDF88230.1 - 0.0038 16.2 0.0 0.0086 15.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 CDF88230.1 - 0.0043 16.7 0.1 0.0091 15.7 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain NTPase_1 PF03266.10 CDF88230.1 - 0.0074 16.0 0.1 0.1 12.2 0.0 2.5 1 1 1 2 2 2 1 NTPase Mg_chelatase PF01078.16 CDF88230.1 - 0.014 14.5 0.0 0.076 12.1 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.1 CDF88230.1 - 0.015 15.1 0.0 0.16 11.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.1 CDF88230.1 - 0.023 14.2 0.0 0.075 12.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 CDF88230.1 - 0.036 13.1 0.0 0.076 12.0 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.1 CDF88230.1 - 0.047 13.5 0.1 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 CDF88230.1 - 0.049 13.9 0.0 0.14 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 CDF88230.1 - 0.049 13.0 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.17 CDF88230.1 - 0.055 13.6 0.0 0.23 11.6 0.0 2.2 1 0 0 1 1 1 0 RNA helicase MobB PF03205.9 CDF88230.1 - 0.098 12.3 0.0 0.27 10.9 0.0 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Enamelin PF15362.1 CDF88230.1 - 0.15 10.0 0.1 0.22 9.5 0.1 1.1 1 0 0 1 1 1 0 Enamelin AAA_30 PF13604.1 CDF88230.1 - 0.15 11.6 0.0 0.59 9.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain TRP PF06011.7 CDF88231.1 - 4.5e-148 493.4 35.3 5.6e-148 493.1 24.5 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 CDF88231.1 - 3.3e-44 150.3 0.9 5.8e-44 149.5 0.6 1.4 1 0 0 1 1 1 1 ML-like domain E3_UbLigase_EDD PF11547.3 CDF88231.1 - 0.089 12.3 0.0 0.2 11.1 0.0 1.5 1 0 0 1 1 1 0 E3 ubiquitin ligase EDD Topoisom_I PF01028.15 CDF88232.1 - 0.052 12.6 0.1 0.093 11.8 0.1 1.4 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, catalytic core Coatomer_WDAD PF04053.9 CDF88233.1 - 5.5e-156 519.7 0.0 7.9e-156 519.2 0.0 1.2 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.27 CDF88233.1 - 1.7e-46 154.4 9.7 3.7e-11 42.4 0.1 7.6 8 0 0 8 8 8 6 WD domain, G-beta repeat BBS2_Mid PF14783.1 CDF88233.1 - 7.3e-05 22.5 0.0 3.6 7.4 0.0 4.8 2 1 2 4 4 4 1 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.3 CDF88233.1 - 0.011 13.8 2.0 5.6 4.9 0.0 4.2 4 2 2 6 6 6 0 Nucleoporin Nup120/160 HTH_Tnp_4 PF13613.1 CDF88233.1 - 0.022 14.2 0.0 0.038 13.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease Poly_export PF02563.11 CDF88233.1 - 0.033 13.9 0.0 9.9 6.0 0.0 2.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis/export protein PQQ PF01011.16 CDF88233.1 - 0.034 13.6 2.2 2.6 7.7 0.0 4.6 5 0 0 5 5 5 0 PQQ enzyme repeat FliH PF02108.11 CDF88233.1 - 0.082 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Flagellar assembly protein FliH TPR_2 PF07719.12 CDF88233.1 - 0.12 12.3 4.4 6.9 6.8 0.2 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat FtsJ PF01728.14 CDF88234.1 - 4.5e-60 202.7 0.0 5.9e-60 202.3 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.1 CDF88234.1 - 5.4e-07 29.4 0.0 1.8e-06 27.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDF88234.1 - 0.00016 21.2 0.0 0.1 12.1 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_18 PF12847.2 CDF88234.1 - 0.016 15.7 0.0 0.05 14.1 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Colicin_immun PF09204.5 CDF88234.1 - 0.037 14.1 0.1 0.11 12.6 0.0 1.8 1 0 0 1 1 1 0 Bacterial self-protective colicin-like immunity Ribosomal_L1 PF00687.16 CDF88235.1 - 5.7e-45 153.3 1.0 6.7e-45 153.1 0.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Cyclin PF08613.6 CDF88236.1 - 6.4e-16 59.1 0.2 2e-15 57.5 0.1 1.8 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 CDF88236.1 - 0.0036 16.8 0.4 0.0082 15.7 0.3 1.7 1 0 0 1 1 1 1 Cyclin, N-terminal domain PilM PF07419.7 CDF88236.1 - 0.13 11.7 0.0 3.5 7.1 0.0 2.4 2 0 0 2 2 2 0 PilM Hormone_3 PF00159.13 CDF88236.1 - 0.14 12.1 0.2 0.38 10.7 0.2 1.7 1 0 0 1 1 1 0 Pancreatic hormone peptide Arf PF00025.16 CDF88237.1 - 1.1e-66 223.3 0.0 1.2e-66 223.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.15 CDF88237.1 - 2.8e-09 36.1 0.5 4.7e-06 25.5 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.17 CDF88237.1 - 7e-09 35.2 0.0 8.6e-09 34.9 0.0 1.2 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 CDF88237.1 - 9e-09 34.7 0.0 1.2e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Miro PF08477.8 CDF88237.1 - 3.2e-08 34.0 0.0 4.9e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 CDF88237.1 - 4.7e-06 26.5 0.0 6.4e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 CDF88237.1 - 4.6e-05 22.6 0.0 5.1e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 CDF88237.1 - 6.9e-05 22.3 0.1 0.0013 18.2 0.0 2.0 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.4 CDF88237.1 - 0.044 13.2 0.0 0.16 11.4 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Tegument_dsDNA PF12818.2 CDF88237.1 - 0.12 11.1 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 dsDNA viral tegument protein DUF663 PF04950.7 CDF88238.1 - 7.2e-104 346.9 0.0 7.2e-104 346.9 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 CDF88238.1 - 4.7e-28 96.5 0.0 1.5e-27 94.9 0.0 2.0 1 0 0 1 1 1 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.22 CDF88238.1 - 1.2e-07 31.3 0.0 1.5e-06 27.7 0.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.1 CDF88238.1 - 2.1e-05 24.6 0.0 6.3e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 CDF88238.1 - 4.1e-05 23.8 0.0 0.0001 22.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 CDF88238.1 - 0.0001 22.1 0.0 0.0004 20.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDF88238.1 - 0.00011 22.3 0.0 0.00029 20.8 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain MobB PF03205.9 CDF88238.1 - 0.0007 19.3 0.3 0.0036 16.9 0.2 2.3 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_17 PF13207.1 CDF88238.1 - 0.00071 20.3 0.0 0.00071 20.3 0.0 3.7 3 1 0 4 4 3 1 AAA domain AAA_19 PF13245.1 CDF88238.1 - 0.00077 19.1 0.3 0.0018 17.9 0.2 1.6 1 0 0 1 1 1 1 Part of AAA domain NACHT PF05729.7 CDF88238.1 - 0.0052 16.4 0.0 0.01 15.5 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Miro PF08477.8 CDF88238.1 - 0.016 15.6 0.2 0.086 13.3 0.0 2.4 2 0 0 2 2 1 0 Miro-like protein AAA_5 PF07728.9 CDF88238.1 - 0.022 14.4 0.1 0.056 13.1 0.1 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) PduV-EutP PF10662.4 CDF88238.1 - 0.023 14.1 0.0 0.11 12.0 0.0 2.0 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.17 CDF88238.1 - 0.049 13.8 0.0 0.15 12.2 0.0 1.9 1 0 0 1 1 1 0 RNA helicase MMR_HSR1 PF01926.18 CDF88238.1 - 0.051 13.5 0.1 0.21 11.5 0.0 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_25 PF13481.1 CDF88238.1 - 0.076 12.4 0.0 0.31 10.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 CDF88238.1 - 0.17 12.1 0.0 0.17 12.1 0.0 4.0 4 0 0 4 4 4 0 AAA domain AAA_11 PF13086.1 CDF88238.1 - 0.45 10.0 0.0 0.45 10.0 0.0 3.3 3 0 0 3 3 3 0 AAA domain WAC_Acf1_DNA_bd PF10537.4 CDF88239.1 - 2.7e-37 127.0 0.8 1.3e-36 124.7 0.5 2.2 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal DDT PF02791.12 CDF88239.1 - 5.9e-16 57.9 1.4 2.3e-14 52.9 0.3 2.5 2 0 0 2 2 2 1 DDT domain WHIM2 PF15613.1 CDF88239.1 - 1.5e-10 40.5 0.5 5.2e-10 38.8 0.2 2.1 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 2 Ubiq_cyt_C_chap PF03981.7 CDF88240.1 - 1.9e-42 144.4 0.3 2.9e-42 143.8 0.2 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone HK PF02110.10 CDF88241.1 - 9.3e-88 293.5 1.3 1.3e-87 293.0 0.9 1.2 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.12 CDF88241.1 - 2.1e-57 193.1 0.0 3.3e-57 192.5 0.0 1.3 1 0 0 1 1 1 1 Thiamine monophosphate synthase/TENI UPF0128 PF03673.8 CDF88241.1 - 0.12 11.5 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0128) LRR_9 PF14580.1 CDF88242.1 - 2.2e-13 50.1 0.8 4.2e-13 49.2 0.6 1.4 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.2 CDF88242.1 - 4.4e-08 32.5 13.0 0.00038 20.0 1.1 3.3 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CDF88242.1 - 0.0032 17.1 9.6 0.13 11.9 2.3 2.9 1 1 3 4 4 4 4 Leucine rich repeat LRR_1 PF00560.28 CDF88242.1 - 0.0058 16.4 13.3 0.81 9.9 0.3 5.2 3 2 2 5 5 5 2 Leucine Rich Repeat MA-Mit PF09245.5 CDF88242.1 - 0.037 13.2 1.1 0.14 11.4 0.2 2.1 1 1 1 2 2 2 0 Mycoplasma arthritidis-derived mitogen ComZ PF10815.3 CDF88242.1 - 0.048 13.4 0.1 1.3 8.8 0.0 2.5 2 0 0 2 2 2 0 ComZ LRR_7 PF13504.1 CDF88242.1 - 0.38 11.1 12.1 27 5.5 0.0 5.7 6 2 0 6 6 6 0 Leucine rich repeat LRR_6 PF13516.1 CDF88242.1 - 5 7.4 12.6 65 4.0 0.0 4.9 2 1 2 4 4 4 0 Leucine Rich repeat BAH PF01426.13 CDF88243.1 - 2.7e-16 59.3 0.3 1e-15 57.5 0.2 2.0 1 0 0 1 1 1 1 BAH domain zf-HC5HC2H_2 PF13832.1 CDF88243.1 - 8.1e-14 51.5 18.0 3.6e-12 46.2 2.2 4.3 3 0 0 3 3 3 2 PHD-zinc-finger like domain PHD PF00628.24 CDF88243.1 - 2.2e-12 46.4 56.1 1.4e-07 31.0 5.8 5.8 4 1 1 5 5 5 3 PHD-finger PHD_2 PF13831.1 CDF88243.1 - 2.3e-05 23.6 5.4 2.3e-05 23.6 3.7 6.1 7 1 0 7 7 7 3 PHD-finger C1_1 PF00130.17 CDF88243.1 - 2.3 8.0 55.5 0.067 12.9 4.6 6.4 5 1 1 6 6 6 0 Phorbol esters/diacylglycerol binding domain (C1 domain) mRNA_cap_enzyme PF01331.14 CDF88244.1 - 9.8e-59 198.2 0.4 3.2e-58 196.6 0.0 1.8 2 0 0 2 2 2 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.10 CDF88244.1 - 6.8e-23 81.0 0.6 3.3e-22 78.8 0.4 2.0 1 1 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.16 CDF88244.1 - 1.4e-07 31.0 0.0 1e-06 28.2 0.0 2.4 2 1 0 2 2 2 1 ATP dependent DNA ligase domain DAP3 PF10236.4 CDF88245.1 - 2.1e-77 260.0 1.2 2.7e-77 259.7 0.8 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.1 CDF88245.1 - 2.5e-05 24.3 0.0 5.8e-05 23.1 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.1 CDF88245.1 - 9.1e-05 22.1 0.0 0.00025 20.7 0.0 1.7 2 0 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 CDF88245.1 - 0.00016 21.8 0.0 0.014 15.4 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 CDF88245.1 - 0.0034 17.5 0.1 0.03 14.5 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.12 CDF88245.1 - 0.0045 16.4 0.0 0.016 14.6 0.0 1.8 2 0 0 2 2 2 1 IstB-like ATP binding protein NACHT PF05729.7 CDF88245.1 - 0.0056 16.3 0.0 0.058 13.0 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_14 PF13173.1 CDF88245.1 - 0.011 15.6 0.0 0.03 14.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 CDF88245.1 - 0.011 15.4 0.0 0.038 13.7 0.0 1.9 1 0 0 1 1 1 0 NTPase AAA_18 PF13238.1 CDF88245.1 - 0.05 13.9 0.1 0.14 12.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain DUF2791 PF10923.3 CDF88245.1 - 0.063 11.8 0.0 0.11 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) AAA_25 PF13481.1 CDF88245.1 - 0.063 12.6 0.0 0.16 11.3 0.0 1.6 2 0 0 2 2 2 0 AAA domain ArgK PF03308.11 CDF88245.1 - 0.18 10.5 0.3 0.55 8.9 0.0 1.8 2 0 0 2 2 2 0 ArgK protein PseudoU_synth_1 PF01416.15 CDF88246.1 - 4.8e-23 81.5 0.0 2.4e-10 40.7 0.0 2.5 2 0 0 2 2 2 2 tRNA pseudouridine synthase UPF0113 PF03657.8 CDF88247.1 - 3.5e-12 46.2 0.0 4.5e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0113) SRP72 PF08492.7 CDF88248.1 - 2.8e-09 37.2 7.8 2.8e-09 37.2 5.4 2.5 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_12 PF13424.1 CDF88248.1 - 6e-05 22.8 7.1 0.0046 16.8 0.2 4.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.1 CDF88248.1 - 0.00034 21.0 0.2 54 4.8 0.0 5.4 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.12 CDF88248.1 - 0.00063 19.4 11.0 1.2 9.1 0.0 5.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_11 PF13414.1 CDF88248.1 - 0.016 14.8 7.1 0.71 9.5 0.2 4.6 5 0 0 5 5 5 0 TPR repeat TPR_1 PF00515.23 CDF88248.1 - 0.049 13.2 3.6 8.2 6.2 0.0 3.8 5 0 0 5 5 5 0 Tetratricopeptide repeat PPR PF01535.15 CDF88248.1 - 0.093 12.7 0.0 26 5.1 0.0 3.6 3 0 0 3 3 3 0 PPR repeat DEAD PF00270.24 CDF88249.1 - 7.6e-31 106.8 0.0 1.5e-30 105.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF88249.1 - 6e-14 51.6 0.1 1.5e-13 50.4 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDF88249.1 - 6.7e-09 35.8 0.0 1.5e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 CDF88249.1 - 3.1e-05 22.9 0.1 4.3e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF2075 PF09848.4 CDF88249.1 - 0.038 12.9 0.0 0.063 12.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Pkinase PF00069.20 CDF88250.1 - 1.9e-71 240.2 0.1 2.4e-71 239.9 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF88250.1 - 5e-46 156.8 0.0 6.9e-46 156.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF88250.1 - 5.2e-07 28.9 0.0 2e-06 26.9 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 CDF88250.1 - 0.058 13.1 0.0 0.14 11.8 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 CDF88250.1 - 0.08 11.9 0.0 0.16 11.0 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RING_2 PF13639.1 CDF88251.1 - 2.3e-11 43.3 8.1 2.3e-11 43.3 5.6 1.9 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.2 CDF88251.1 - 3.1e-08 33.6 5.7 7e-08 32.4 4.0 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger zf-Apc11 PF12861.2 CDF88251.1 - 3.9e-06 26.6 3.1 3.9e-06 26.6 2.1 1.7 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.20 CDF88251.1 - 8.4e-06 25.3 6.6 8.4e-06 25.3 4.6 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDF88251.1 - 2.1e-05 24.4 6.7 2.1e-05 24.4 4.7 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 CDF88251.1 - 2.2e-05 24.0 1.1 7e-05 22.4 0.3 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.1 CDF88251.1 - 6e-05 22.6 3.6 0.00012 21.6 2.5 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 CDF88251.1 - 0.00035 20.1 5.7 0.00035 20.1 3.9 2.0 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.3 CDF88251.1 - 0.00098 18.5 4.0 0.0031 16.9 1.7 2.1 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.1 CDF88251.1 - 0.0039 17.0 8.1 0.015 15.2 5.6 2.0 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-P11 PF03854.9 CDF88251.1 - 0.18 11.3 6.0 0.12 11.8 0.5 2.3 2 0 0 2 2 2 0 P-11 zinc finger zf-RING_4 PF14570.1 CDF88251.1 - 0.26 10.8 6.4 0.15 11.6 2.7 1.9 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.3 CDF88251.1 - 0.49 10.3 8.2 0.46 10.4 2.8 2.5 2 1 0 2 2 2 0 FANCL C-terminal domain Rad50_zn_hook PF04423.9 CDF88251.1 - 1.4 8.4 4.1 16 5.0 0.1 2.6 2 0 0 2 2 2 0 Rad50 zinc hook motif Cys_rich_CPXG PF14255.1 CDF88251.1 - 3.1 7.6 8.4 23 4.8 0.1 3.4 3 0 0 3 3 3 0 Cysteine-rich CPXCG Ribosomal_S10 PF00338.17 CDF88252.1 - 8.6e-27 92.8 0.0 1.3e-26 92.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e FtsJ PF01728.14 CDF88253.1 - 2.3e-64 216.7 0.0 3e-64 216.3 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.1 CDF88253.1 - 0.034 13.8 0.0 0.057 13.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain E1-E2_ATPase PF00122.15 CDF88254.1 - 4.1e-63 212.5 5.0 8.8e-63 211.4 3.4 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 CDF88254.1 - 1.1e-34 119.6 1.4 1.1e-34 119.6 1.0 2.8 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CDF88254.1 - 1e-26 94.7 0.0 3.2e-25 89.8 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CDF88254.1 - 2.1e-17 62.8 0.0 3.9e-17 61.9 0.0 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit HAD PF12710.2 CDF88254.1 - 3.8e-15 56.5 0.0 9.7e-15 55.2 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.21 CDF88254.1 - 9e-15 53.8 0.0 2.8e-14 52.3 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 CDF88254.1 - 0.0015 18.1 0.5 0.0035 16.9 0.3 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase tRNA-synt_2 PF00152.15 CDF88255.1 - 1.5e-87 293.5 0.4 2.2e-87 292.9 0.3 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 CDF88255.1 - 6.4e-12 45.1 0.1 3.7e-11 42.7 0.1 2.2 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 CDF88255.1 - 9.4e-08 31.5 0.0 0.00072 18.8 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FCP1_C PF09309.5 CDF88255.1 - 0.026 13.8 1.7 0.045 13.0 1.2 1.3 1 0 0 1 1 1 0 FCP1, C-terminal ORC2 PF04084.9 CDF88256.1 - 6.9e-109 363.6 0.8 8.9e-109 363.2 0.6 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 AT_hook PF02178.14 CDF88256.1 - 0.18 11.5 7.5 0.57 10.0 5.2 1.9 1 0 0 1 1 1 0 AT hook motif Pkinase PF00069.20 CDF88257.1 - 7.6e-37 126.8 0.0 1.3e-36 126.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF88257.1 - 2.2e-24 85.9 0.0 3.1e-24 85.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Rota_NS6 PF04866.7 CDF88257.1 - 0.0094 15.9 0.0 0.019 14.9 0.0 1.5 1 0 0 1 1 1 1 Rotavirus non-structural protein 6 APH PF01636.18 CDF88257.1 - 0.038 13.7 0.0 0.22 11.2 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.1 CDF88257.1 - 0.077 11.9 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Dynamitin PF04912.9 CDF88259.1 - 0.06 12.1 0.1 0.07 11.9 0.1 1.0 1 0 0 1 1 1 0 Dynamitin PRP4 PF08799.6 CDF88259.1 - 0.12 11.6 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like DUF3317 PF11779.3 CDF88260.1 - 0.068 12.6 0.3 0.08 12.3 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3317) Lipid_DES PF08557.5 CDF88261.1 - 1.9e-20 71.7 0.3 3.5e-20 70.9 0.2 1.5 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) FA_desaturase PF00487.19 CDF88261.1 - 7.6e-18 64.8 17.7 1.3e-09 37.9 5.7 2.2 2 0 0 2 2 2 2 Fatty acid desaturase ECH PF00378.15 CDF88262.1 - 2.1e-26 92.5 0.3 1.1e-25 90.1 0.0 1.9 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase family ECH_C PF13766.1 CDF88262.1 - 1.2e-22 80.2 0.1 2.5e-22 79.2 0.1 1.5 1 0 0 1 1 1 1 2-enoyl-CoA Hydratase C-terminal region DUF1896 PF08989.5 CDF88262.1 - 0.024 14.5 0.1 0.17 11.7 0.0 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF1896) UCH PF00443.24 CDF88263.1 - 5.7e-44 150.2 0.0 1.2e-43 149.2 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CDF88263.1 - 2.7e-26 92.6 0.0 7.5e-26 91.2 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.14 CDF88263.1 - 2.6e-22 78.6 12.4 7.5e-20 70.8 3.5 2.9 2 0 0 2 2 2 2 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.26 CDF88263.1 - 1.2e-10 40.8 1.2 0.00018 21.2 0.0 2.6 2 0 0 2 2 2 2 UBA/TS-N domain CTD PF12815.2 CDF88264.1 - 0.069 13.5 1.6 0.13 12.7 1.0 1.5 1 1 0 1 1 1 0 Spt5 C-terminal nonapeptide repeat binding Spt4 Nicastrin PF05450.10 CDF88264.1 - 0.12 11.5 2.5 1.1 8.4 0.1 2.5 1 1 2 3 3 3 0 Nicastrin DUF4099 PF13351.1 CDF88264.1 - 0.15 11.9 2.2 1.4 8.8 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4099) DUF3166 PF11365.3 CDF88264.1 - 0.84 10.1 6.9 1.5 9.3 0.4 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3166) DivIC PF04977.10 CDF88264.1 - 0.88 9.0 16.2 1.9 8.0 0.9 3.6 3 1 1 4 4 4 0 Septum formation initiator TSC22 PF01166.13 CDF88264.1 - 1.5 8.8 11.2 5 7.1 0.7 3.4 3 0 0 3 3 3 0 TSC-22/dip/bun family DAHP_synth_1 PF00793.15 CDF88265.1 - 6.3e-101 336.6 0.0 7.4e-101 336.3 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family AMP-binding PF00501.23 CDF88266.1 - 0.064 11.6 0.0 0.096 11.0 0.0 1.2 1 0 0 1 1 1 0 AMP-binding enzyme PRP1_N PF06424.7 CDF88267.1 - 1.5e-28 99.7 0.0 1.5e-28 99.7 0.0 2.0 2 0 0 2 2 1 1 PRP1 splicing factor, N-terminal TPR_19 PF14559.1 CDF88267.1 - 3.4e-21 75.3 10.5 0.00039 20.6 0.1 7.0 7 1 0 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.1 CDF88267.1 - 2.4e-20 71.1 4.2 0.0092 16.5 0.1 9.4 9 2 1 10 10 9 5 Tetratricopeptide repeat TPR_16 PF13432.1 CDF88267.1 - 1.4e-18 67.0 1.9 0.014 16.0 0.0 7.8 6 3 1 7 7 7 5 Tetratricopeptide repeat TPR_11 PF13414.1 CDF88267.1 - 5.2e-15 54.8 8.3 9.9e-06 25.1 0.0 6.6 4 3 2 7 7 7 2 TPR repeat TPR_2 PF07719.12 CDF88267.1 - 3.8e-11 42.0 14.4 0.16 11.9 0.0 9.3 10 1 1 11 11 10 4 Tetratricopeptide repeat TPR_8 PF13181.1 CDF88267.1 - 4.2e-07 29.2 12.7 0.0011 18.6 0.0 7.6 9 1 1 10 10 10 1 Tetratricopeptide repeat TPR_1 PF00515.23 CDF88267.1 - 7.2e-06 25.3 10.1 0.15 11.7 0.0 6.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.1 CDF88267.1 - 4.7e-05 23.2 5.7 0.3 11.3 0.0 5.8 7 0 0 7 7 5 1 Tetratricopeptide repeat TPR_6 PF13174.1 CDF88267.1 - 0.00011 22.4 9.3 7.5 7.2 0.0 7.6 8 0 0 8 8 7 1 Tetratricopeptide repeat NRDE-2 PF08424.5 CDF88267.1 - 0.00024 20.1 22.2 0.0082 15.0 2.8 5.0 4 1 1 5 5 5 2 NRDE-2, necessary for RNA interference TPR_7 PF13176.1 CDF88267.1 - 0.0032 17.1 3.1 1.8 8.5 0.0 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.1 CDF88267.1 - 0.0036 17.1 15.3 1.6 8.7 0.2 7.0 6 3 1 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.1 CDF88267.1 - 0.33 10.8 6.2 7.2 6.5 0.1 4.4 4 1 1 5 5 5 0 Tetratricopeptide repeat Fungal_trans_2 PF11951.3 CDF88268.1 - 2.7e-24 85.5 0.4 4.4e-24 84.8 0.3 1.3 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF88268.1 - 5e-07 29.5 12.4 9.1e-07 28.6 8.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Siva PF05458.7 CDF88268.1 - 0.049 13.2 1.8 0.086 12.4 1.3 1.3 1 0 0 1 1 1 0 Cd27 binding protein (Siva) Arginase PF00491.16 CDF88269.1 - 1.6e-79 267.1 0.1 1.9e-79 266.8 0.1 1.1 1 0 0 1 1 1 1 Arginase family MatE PF01554.13 CDF88270.1 - 1.6e-47 161.1 20.7 6.9e-28 97.3 6.9 2.3 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.1 CDF88270.1 - 8.4e-07 28.8 2.8 8.4e-07 28.8 1.9 3.1 3 0 0 3 3 3 1 Polysaccharide biosynthesis C-terminal domain FMN_red PF03358.10 CDF88271.1 - 3.7e-09 36.2 0.0 5e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_1 PF00258.20 CDF88271.1 - 0.00051 20.0 0.0 0.0025 17.8 0.0 2.0 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_2 PF02525.12 CDF88271.1 - 0.038 13.4 0.0 0.048 13.1 0.0 1.2 1 0 0 1 1 1 0 Flavodoxin-like fold UCH_1 PF13423.1 CDF88272.1 - 3.5e-54 184.2 0.4 5.5e-54 183.5 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.19 CDF88272.1 - 9.1e-22 78.0 0.0 1.6e-21 77.3 0.0 1.4 1 0 0 1 1 1 1 Exonuclease WD40 PF00400.27 CDF88273.1 - 3.8e-19 67.7 21.6 5.4e-06 26.0 0.1 9.4 11 0 0 11 11 11 4 WD domain, G-beta repeat Nup160 PF11715.3 CDF88273.1 - 0.00026 19.2 6.7 0.01 14.0 0.0 3.9 3 1 1 4 4 4 2 Nucleoporin Nup120/160 CPSF_A PF03178.10 CDF88273.1 - 0.0087 15.1 0.4 5.3 6.0 0.0 4.1 4 1 0 4 4 4 2 CPSF A subunit region Ribosomal_L36 PF00444.13 CDF88274.1 - 4.9e-21 74.4 10.2 6.5e-21 74.0 7.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L36 Crust_neurohorm PF01147.12 CDF88274.1 - 0.0068 15.6 2.1 0.01 15.1 1.4 1.2 1 0 0 1 1 1 1 Crustacean CHH/MIH/GIH neurohormone family Abhydrolase_5 PF12695.2 CDF88276.1 - 8.7e-18 64.4 0.0 1.2e-17 64.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CDF88276.1 - 3.3e-16 59.8 0.0 4.3e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 CDF88276.1 - 8.3e-12 44.7 0.1 1.5e-11 43.9 0.1 1.5 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_1 PF00561.15 CDF88276.1 - 1.6e-10 40.9 0.0 3e-10 40.0 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.13 CDF88276.1 - 0.00038 19.8 0.0 0.22 10.7 0.0 2.3 2 1 0 2 2 2 2 Dienelactone hydrolase family Esterase PF00756.15 CDF88276.1 - 0.016 14.5 0.0 0.026 13.9 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Abhydrolase_3 PF07859.8 CDF88276.1 - 0.02 14.4 0.0 0.083 12.4 0.0 1.8 1 1 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.8 CDF88276.1 - 0.027 14.0 0.0 0.039 13.5 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein AXE1 PF05448.7 CDF88276.1 - 0.034 12.6 0.0 0.94 7.9 0.0 2.1 1 1 0 2 2 2 0 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.16 CDF88276.1 - 0.05 12.8 0.1 0.87 8.7 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family LCAT PF02450.10 CDF88276.1 - 0.11 11.4 0.1 0.35 9.7 0.0 1.8 1 1 1 2 2 2 0 Lecithin:cholesterol acyltransferase Ceramidase PF05875.7 CDF88278.1 - 4.9e-94 314.3 15.6 5.6e-94 314.1 10.8 1.0 1 0 0 1 1 1 1 Ceramidase Radical_SAM PF04055.16 CDF88279.1 - 2.2e-17 63.7 0.8 4.5e-17 62.7 0.1 1.8 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.19 CDF88279.1 - 2.5e-12 46.6 0.1 6.6e-12 45.2 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CDF88279.1 - 0.098 12.8 0.1 0.24 11.5 0.1 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Sec16_C PF12931.2 CDF88280.1 - 1.8e-77 260.8 0.0 3.2e-77 260.0 0.0 1.4 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.2 CDF88280.1 - 3.5e-16 59.2 0.2 3.5e-16 59.2 0.2 2.7 3 0 0 3 3 3 1 Vesicle coat trafficking protein Sec16 mid-region MBA1 PF07961.6 CDF88281.1 - 7.9e-102 339.0 1.2 1e-101 338.7 0.8 1.1 1 0 0 1 1 1 1 MBA1-like protein BRO1 PF03097.13 CDF88282.1 - 1.7e-93 313.4 14.1 1.7e-93 313.4 9.8 2.2 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 CDF88282.1 - 4.3e-42 144.0 13.7 4.3e-42 144.0 9.5 2.1 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV tRNA_int_end_N2 PF12928.2 CDF88283.1 - 2.3e-20 71.8 0.0 4.5e-20 70.8 0.0 1.5 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term NIP_1 PF08995.5 CDF88284.1 - 5.7 7.1 14.1 6.4 7.0 9.7 1.0 1 0 0 1 1 1 0 Necrosis inducing protein-1 AAA PF00004.24 CDF88285.1 - 4.5e-33 114.2 0.0 9.7e-33 113.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 CDF88285.1 - 9.8e-07 28.4 0.0 2.6e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_17 PF13207.1 CDF88285.1 - 2.5e-06 28.3 0.0 6.7e-06 26.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CDF88285.1 - 1.5e-05 25.1 0.1 9.4e-05 22.5 0.0 2.3 2 1 0 2 2 1 1 AAA domain AAA_18 PF13238.1 CDF88285.1 - 3e-05 24.3 0.0 0.00013 22.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 CDF88285.1 - 0.0001 22.0 0.2 0.045 13.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) T2SE PF00437.15 CDF88285.1 - 0.00022 20.2 0.1 0.0084 15.0 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_11 PF13086.1 CDF88285.1 - 0.00025 20.7 0.0 0.00052 19.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDF88285.1 - 0.00054 19.9 0.0 0.002 18.1 0.0 2.0 2 1 0 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.17 CDF88285.1 - 0.00066 19.8 0.0 0.015 15.4 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_33 PF13671.1 CDF88285.1 - 0.0013 18.6 0.0 0.0033 17.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain UPF0079 PF02367.12 CDF88285.1 - 0.0014 18.2 0.0 0.0026 17.3 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 Rad17 PF03215.10 CDF88285.1 - 0.0034 16.1 0.0 0.0061 15.2 0.0 1.4 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_30 PF13604.1 CDF88285.1 - 0.0084 15.7 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 CDF88285.1 - 0.009 15.6 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 CDF88285.1 - 0.01 15.7 0.0 0.031 14.1 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.1 CDF88285.1 - 0.016 14.5 0.0 0.055 12.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.7 CDF88285.1 - 0.018 14.1 0.0 0.15 11.0 0.0 2.4 3 0 0 3 3 3 0 Holliday junction DNA helicase ruvB N-terminus AAA_31 PF13614.1 CDF88285.1 - 0.023 14.6 0.1 0.14 12.0 0.1 2.2 1 1 0 1 1 1 0 AAA domain NACHT PF05729.7 CDF88285.1 - 0.026 14.1 0.0 0.078 12.6 0.0 1.8 1 0 0 1 1 1 0 NACHT domain MobB PF03205.9 CDF88285.1 - 0.027 14.1 0.4 0.097 12.3 0.0 2.1 3 0 0 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B DUF2075 PF09848.4 CDF88285.1 - 0.032 13.2 0.0 0.049 12.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Arch_ATPase PF01637.13 CDF88285.1 - 0.034 13.8 0.1 0.17 11.5 0.1 2.0 1 1 0 1 1 1 0 Archaeal ATPase AAA_23 PF13476.1 CDF88285.1 - 0.036 14.4 0.0 0.073 13.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 CDF88285.1 - 0.044 13.4 0.1 0.083 12.6 0.0 1.4 1 0 0 1 1 1 0 NTPase Sigma54_activ_2 PF14532.1 CDF88285.1 - 0.046 13.7 0.0 0.22 11.5 0.0 2.2 1 1 0 1 1 1 0 Sigma-54 interaction domain Mg_chelatase PF01078.16 CDF88285.1 - 0.061 12.4 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.17 CDF88285.1 - 0.068 12.0 0.0 0.14 10.9 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_3 PF07726.6 CDF88285.1 - 0.081 12.5 0.0 1.3 8.5 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 CDF88285.1 - 0.12 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain UPF0016 PF01169.14 CDF88286.1 - 3.1e-40 136.1 20.0 1.6e-20 73.0 3.3 2.1 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 TauE PF01925.14 CDF88286.1 - 0.013 14.9 0.8 0.013 14.9 0.6 2.3 2 1 0 2 2 2 0 Sulfite exporter TauE/SafE DUF3962 PF13111.1 CDF88286.1 - 0.18 11.1 0.2 5.6 6.3 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3962) DUF1673 PF07895.6 CDF88286.1 - 2.8 7.4 5.0 32 3.9 0.0 2.6 1 1 1 3 3 3 0 Protein of unknown function (DUF1673) DUF204 PF02659.10 CDF88286.1 - 5.9 7.1 11.7 1.4 9.0 2.3 2.9 2 1 0 2 2 2 0 Domain of unknown function DUF KTI12 PF08433.5 CDF88287.1 - 0.0071 15.5 3.5 0.015 14.5 2.4 1.7 1 1 0 1 1 1 1 Chromatin associated protein KTI12 DMPK_coil PF08826.5 CDF88287.1 - 0.01 15.7 0.6 0.01 15.7 0.4 2.6 1 1 0 2 2 2 0 DMPK coiled coil domain like FCH PF00611.18 CDF88287.1 - 0.019 15.1 3.7 2.9 8.1 0.8 2.4 2 0 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain DUF4254 PF14063.1 CDF88287.1 - 0.021 14.4 5.4 0.035 13.7 3.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4254) DUF4407 PF14362.1 CDF88287.1 - 0.027 13.4 7.4 0.036 13.0 5.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2001 PF09393.5 CDF88287.1 - 0.027 14.1 0.7 0.034 13.8 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2001) cwf18 PF08315.7 CDF88287.1 - 0.13 12.7 15.1 0.73 10.3 5.2 2.3 1 1 1 2 2 2 0 cwf18 pre-mRNA splicing factor Nexin_C PF08628.7 CDF88287.1 - 0.23 11.5 4.2 0.092 12.8 1.2 1.6 2 0 0 2 2 2 0 Sorting nexin C terminal DUF416 PF04222.7 CDF88287.1 - 1.1 8.3 5.7 0.42 9.7 1.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF416) Exonuc_VII_L PF02601.10 CDF88287.1 - 1.7 7.8 11.2 2.1 7.4 7.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2924 PF11149.3 CDF88287.1 - 2.1 8.3 5.6 8 6.4 3.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2924) DUF724 PF05266.9 CDF88287.1 - 4 7.0 11.0 5.2 6.6 7.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF1690 PF07956.6 CDF88287.1 - 4.5 7.2 15.5 3.3 7.6 6.6 2.1 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) YgaB PF14182.1 CDF88287.1 - 6.8 6.9 9.0 0.47 10.7 1.4 2.3 1 1 0 2 2 2 0 YgaB-like protein CCDC-167 PF15188.1 CDF88287.1 - 9.2 6.2 9.7 3.9 7.4 0.1 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 DUF3535 PF12054.3 CDF88288.1 - 4.9e-139 463.7 0.0 1.3e-138 462.3 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3535) SNF2_N PF00176.18 CDF88288.1 - 4.4e-78 262.1 0.0 7.3e-78 261.3 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CDF88288.1 - 6.9e-14 51.4 0.0 2.9e-13 49.4 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HEAT PF02985.17 CDF88288.1 - 4.9e-10 38.6 6.5 0.24 11.5 0.0 8.0 7 0 0 7 7 7 3 HEAT repeat Vac14_Fab1_bd PF12755.2 CDF88288.1 - 2.1e-05 24.8 0.2 0.74 10.2 0.0 4.5 5 0 0 5 5 5 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.1 CDF88288.1 - 0.00026 21.3 8.7 45 4.7 0.0 8.0 8 0 0 8 8 8 0 HEAT-like repeat HMGL-like PF00682.14 CDF88289.1 - 5e-74 248.9 0.1 7.5e-74 248.3 0.1 1.3 1 0 0 1 1 1 1 HMGL-like FliG_N PF14842.1 CDF88289.1 - 0.0072 16.4 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 FliG N-terminal domain GcpE PF04551.9 CDF88289.1 - 0.0083 14.9 0.1 0.014 14.1 0.1 1.4 1 1 0 1 1 1 1 GcpE protein Trp_syntA PF00290.15 CDF88289.1 - 0.014 13.9 0.0 1.9 6.9 0.0 2.5 2 0 0 2 2 2 0 Tryptophan synthase alpha chain Ribosomal_S4 PF00163.14 CDF88290.1 - 3e-24 85.2 1.3 5.7e-24 84.3 0.9 1.5 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.20 CDF88290.1 - 1.4e-11 43.6 0.5 1.4e-11 43.6 0.3 2.2 2 0 0 2 2 2 1 S4 domain Ribosomal_L21e PF01157.13 CDF88291.1 - 1.5e-37 127.3 3.6 2.6e-37 126.5 2.5 1.4 1 0 0 1 1 1 1 Ribosomal protein L21e DUF1989 PF09347.5 CDF88291.1 - 0.005 16.2 0.0 0.0065 15.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) Cerato-platanin PF07249.7 CDF88291.1 - 0.11 12.5 0.1 0.17 11.8 0.1 1.3 1 0 0 1 1 1 0 Cerato-platanin Mito_carr PF00153.22 CDF88292.1 - 7.7e-79 259.5 3.2 5.6e-28 96.4 0.3 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Med8 PF10232.4 CDF88293.1 - 1.1e-43 149.4 2.1 1.3e-43 149.1 1.5 1.1 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 NpwBP PF12622.2 CDF88294.1 - 7.5e-12 45.5 2.6 9.8e-12 45.1 1.8 1.2 1 0 0 1 1 1 1 mRNA biogenesis factor Mt_ATP-synt_B PF05405.9 CDF88295.1 - 7.7e-54 181.5 9.8 9.3e-54 181.2 6.8 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) SRX PF09201.5 CDF88295.1 - 0.0095 15.5 1.0 0.014 15.0 0.7 1.3 1 0 0 1 1 1 1 SRX SLS PF14611.1 CDF88295.1 - 0.0097 15.3 2.4 0.014 14.8 1.6 1.2 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator WD40 PF00400.27 CDF88296.1 - 4.2e-22 77.1 9.0 9.1e-05 22.1 0.0 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat CAF1C_H4-bd PF12265.3 CDF88296.1 - 1.1e-17 63.7 0.6 2e-17 62.8 0.4 1.5 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex eIF2A PF08662.6 CDF88296.1 - 0.0003 20.5 0.0 0.065 12.9 0.0 2.6 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 CDF88296.1 - 0.0033 15.6 2.4 0.045 11.8 0.0 2.6 3 0 0 3 3 3 2 Nucleoporin Nup120/160 PGI PF00342.14 CDF88297.1 - 2.7e-224 745.0 3.3 3.1e-224 744.8 2.3 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase SAP30_Sin3_bdg PF13867.1 CDF88297.1 - 0.14 12.0 5.6 1.5 8.7 0.1 2.8 3 0 0 3 3 3 0 Sin3 binding region of histone deacetylase complex subunit SAP30 WD40 PF00400.27 CDF88298.1 - 5.8e-56 184.4 18.3 6.2e-12 44.9 0.1 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_90kDa PF04494.10 CDF88298.1 - 1.4e-48 164.6 1.6 2.7e-48 163.6 1.1 1.5 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit LisH PF08513.6 CDF88298.1 - 1.5e-05 24.5 0.1 3.5e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 LisH Nup160 PF11715.3 CDF88298.1 - 2.7e-05 22.5 1.4 0.087 10.9 0.0 3.5 2 2 2 4 4 4 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.11 CDF88298.1 - 0.072 11.3 0.0 0.44 8.7 0.0 2.0 2 0 0 2 2 2 0 Cytochrome D1 heme domain DUF4175 PF13779.1 CDF88298.1 - 9.8 3.7 24.1 15 3.1 16.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) GPI2 PF06432.6 CDF88299.1 - 5.1e-49 167.1 23.1 7.2e-49 166.6 16.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Phage_int_SAM_4 PF13495.1 CDF88299.1 - 0.014 15.6 0.0 0.04 14.2 0.0 1.7 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain zf-C2H2_4 PF13894.1 CDF88301.1 - 8.4e-05 22.6 22.9 0.048 13.9 1.1 4.3 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.21 CDF88301.1 - 0.00027 21.0 7.7 0.0026 18.0 1.0 4.1 4 1 0 4 4 4 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CDF88301.1 - 0.063 13.5 19.6 3.5 8.0 0.8 4.6 4 1 0 4 4 4 0 Zinc-finger double domain DUF629 PF04780.7 CDF88301.1 - 0.097 11.1 1.0 3.7 5.9 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF629) WRKY PF03106.10 CDF88301.1 - 1.3 8.9 6.1 0.31 10.9 0.2 2.8 3 0 0 3 3 3 0 WRKY DNA -binding domain zf-C2H2_2 PF12756.2 CDF88301.1 - 3.4 7.8 11.3 0.74 9.9 0.1 2.6 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) Transaldolase PF00923.14 CDF88302.1 - 2.2e-94 315.8 0.0 2.5e-94 315.6 0.0 1.0 1 0 0 1 1 1 1 Transaldolase MOSP_N PF02707.11 CDF88302.1 - 0.066 12.7 0.0 0.78 9.2 0.0 2.1 2 0 0 2 2 2 0 Major Outer Sheath Protein N-terminal region DUF2439 PF10382.4 CDF88303.1 - 4e-16 58.9 0.0 5.6e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) DUF2550 PF10739.4 CDF88303.1 - 0.012 15.5 0.3 0.018 15.0 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2550) LRR_4 PF12799.2 CDF88305.1 - 5.1e-06 25.9 18.6 0.063 12.9 0.2 5.6 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CDF88305.1 - 0.00071 19.2 11.3 0.093 12.4 0.5 4.8 3 1 0 3 3 3 2 Leucine rich repeat LRR_1 PF00560.28 CDF88305.1 - 0.0029 17.4 9.9 16 6.0 0.1 6.5 5 1 1 6 6 6 1 Leucine Rich Repeat LRR_7 PF13504.1 CDF88305.1 - 0.059 13.5 11.7 22 5.8 0.1 6.6 6 0 0 6 6 6 0 Leucine rich repeat UNC119_bdg PF15435.1 CDF88305.1 - 0.097 11.9 0.1 0.3 10.4 0.0 1.8 2 0 0 2 2 2 0 UNC119-binding protein C5orf30 homologue LRR_6 PF13516.1 CDF88305.1 - 0.69 10.1 21.2 17 5.8 0.1 6.8 7 0 0 7 7 7 0 Leucine Rich repeat Pkinase PF00069.20 CDF88306.1 - 1.2e-71 240.9 0.0 1.5e-71 240.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF88306.1 - 2.6e-32 111.9 0.0 3.7e-32 111.4 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF88306.1 - 1e-05 24.6 0.0 1.6e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 CDF88306.1 - 0.005 15.9 0.1 0.038 13.0 0.0 2.0 1 1 1 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CDF88306.1 - 0.024 14.3 0.0 0.043 13.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family DAO PF01266.19 CDF88307.1 - 2.2e-23 82.7 0.1 2.5e-23 82.5 0.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 CDF88307.1 - 0.043 13.8 1.2 0.085 12.8 0.2 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain CN_hydrolase PF00795.17 CDF88308.1 - 2.2e-31 108.6 0.0 3e-31 108.2 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase ACBP PF00887.14 CDF88309.1 - 9.4e-28 95.7 3.0 1e-27 95.5 2.1 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein HEAT PF02985.17 CDF88310.1 - 7.9e-16 56.6 19.2 0.00015 21.5 0.1 10.3 11 0 0 11 11 11 3 HEAT repeat HEAT_EZ PF13513.1 CDF88310.1 - 6.7e-14 51.8 11.9 9.7e-06 25.9 0.0 9.8 9 3 2 11 11 11 4 HEAT-like repeat HEAT_2 PF13646.1 CDF88310.1 - 3.9e-12 46.2 5.1 2.5e-05 24.4 0.0 6.7 3 2 2 5 5 5 2 HEAT repeats IBN_N PF03810.14 CDF88310.1 - 1.3e-10 41.0 3.7 6.7e-10 38.7 0.4 3.7 4 0 0 4 4 4 1 Importin-beta N-terminal domain CLASP_N PF12348.3 CDF88310.1 - 5e-05 22.7 0.0 0.3 10.4 0.0 4.0 2 1 0 3 3 3 2 CLASP N terminal DUF3385 PF11865.3 CDF88310.1 - 6.6e-05 22.8 0.1 0.68 9.8 0.0 4.3 2 2 2 4 4 4 1 Domain of unknown function (DUF3385) Arm PF00514.18 CDF88310.1 - 8.4e-05 22.2 5.8 0.034 13.9 0.0 5.9 7 0 0 7 7 7 1 Armadillo/beta-catenin-like repeat RICTOR_V PF14668.1 CDF88310.1 - 0.034 14.0 0.3 1.1 9.2 0.0 3.3 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, domain 5 TIP120 PF08623.5 CDF88310.1 - 0.076 12.6 0.4 2.8 7.4 0.0 2.8 1 1 1 2 2 2 0 TATA-binding protein interacting (TIP20) PAP2 PF01569.16 CDF88311.1 - 7.1e-23 80.7 0.8 1.1e-22 80.0 0.5 1.3 1 0 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.9 CDF88311.1 - 0.097 12.3 0.1 1.9 8.2 0.0 2.2 2 0 0 2 2 2 0 Divergent PAP2 family 6PF2K PF01591.13 CDF88313.1 - 6.5e-63 211.7 0.4 9.3e-63 211.2 0.3 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 CDF88313.1 - 7.7e-21 74.8 0.4 8.6e-20 71.4 0.0 2.5 2 1 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) KOW PF00467.24 CDF88314.1 - 0.00071 19.2 1.0 0.0013 18.3 0.3 1.8 2 1 0 2 2 2 1 KOW motif TIM21 PF08294.6 CDF88315.1 - 8.4e-55 184.4 0.0 1.1e-54 184.0 0.0 1.2 1 0 0 1 1 1 1 TIM21 DUF411 PF04214.8 CDF88315.1 - 0.14 11.6 0.1 0.38 10.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF Glyco_hydro_72 PF03198.9 CDF88316.1 - 2.3e-136 453.9 1.1 2.9e-136 453.5 0.8 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.8 CDF88316.1 - 7.2e-16 58.4 0.1 1.7e-15 57.2 0.1 1.7 1 0 0 1 1 1 1 X8 domain Glucan_synthase PF02364.10 CDF88317.1 - 0 1453.4 0.0 0 1453.0 0.0 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.1 CDF88317.1 - 2.1e-39 134.0 0.0 5.3e-39 132.7 0.0 1.8 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Abhydrolase_6 PF12697.2 CDF88318.1 - 3e-30 105.8 0.0 4.4e-30 105.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDF88318.1 - 1.5e-17 63.9 0.0 1.8e-15 57.1 0.0 2.5 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CDF88318.1 - 2.5e-12 46.7 0.0 3.2e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 CDF88318.1 - 1e-09 38.3 0.0 1.7e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein DUF2305 PF10230.4 CDF88318.1 - 0.0046 16.4 0.0 0.013 14.9 0.0 1.7 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Esterase PF00756.15 CDF88318.1 - 0.0064 15.9 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Putative esterase DUF676 PF05057.9 CDF88318.1 - 0.019 14.2 0.0 0.042 13.1 0.0 1.5 2 0 0 2 2 2 0 Putative serine esterase (DUF676) Hydrolase_4 PF12146.3 CDF88318.1 - 0.022 14.6 0.0 0.062 13.1 0.0 1.7 1 0 0 1 1 1 0 Putative lysophospholipase Thioesterase PF00975.15 CDF88318.1 - 0.052 13.7 0.0 0.16 12.1 0.0 1.8 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_3 PF07859.8 CDF88318.1 - 0.063 12.8 0.0 0.09 12.3 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.20 CDF88318.1 - 0.065 12.8 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF3141 PF11339.3 CDF88318.1 - 0.08 11.2 0.0 0.13 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) Abhydrolase_2 PF02230.11 CDF88318.1 - 0.086 12.2 0.0 0.34 10.3 0.0 1.9 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DUF1192 PF06698.6 CDF88319.1 - 0.07 12.9 0.2 0.27 11.0 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Ribosomal_L10 PF00466.15 CDF88320.1 - 5e-27 93.7 0.2 8.3e-27 93.0 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.14 CDF88320.1 - 4.6e-20 71.8 5.5 3.2e-19 69.0 1.7 2.3 2 0 0 2 2 2 1 60s Acidic ribosomal protein CT47 PF15623.1 CDF88320.1 - 0.013 15.3 5.7 0.02 14.6 4.0 1.3 1 0 0 1 1 1 0 Cancer/testis gene family 47 Alba PF01918.16 CDF88321.1 - 8.1e-06 25.3 0.1 6.6e-05 22.4 0.0 2.3 2 1 0 2 2 2 1 Alba DUF3445 PF11927.3 CDF88322.1 - 1.3e-65 221.3 0.1 1.8e-65 220.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) WH2 PF02205.15 CDF88323.1 - 7.5e-14 50.8 4.0 2e-10 39.9 0.2 3.2 3 0 0 3 3 3 2 WH2 motif Evr1_Alr PF04777.8 CDF88324.1 - 1.7e-30 104.7 5.5 1.7e-30 104.7 3.8 1.7 2 0 0 2 2 2 1 Erv1 / Alr family Toxin-deaminase PF14424.1 CDF88324.1 - 0.007 16.3 0.1 2.5 8.0 0.0 2.2 1 1 1 2 2 2 2 The BURPS668_1122 family of deaminases AAA PF00004.24 CDF88325.1 - 1.9e-36 125.1 0.0 3.5e-36 124.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CDF88325.1 - 1.7e-07 31.4 0.2 6.6e-05 22.9 0.0 3.0 2 1 1 3 3 3 1 AAA ATPase domain AAA_14 PF13173.1 CDF88325.1 - 1.1e-06 28.5 0.0 2.7e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CDF88325.1 - 1.8e-06 28.7 0.0 5e-06 27.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 CDF88325.1 - 2.3e-06 26.8 0.0 1.3e-05 24.3 0.0 2.2 2 1 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 CDF88325.1 - 3.7e-06 27.1 0.1 0.00018 21.6 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 CDF88325.1 - 1.6e-05 24.8 0.0 0.0001 22.1 0.0 2.2 3 0 0 3 3 2 1 AAA domain AAA_2 PF07724.9 CDF88325.1 - 2.6e-05 24.2 0.0 8e-05 22.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 CDF88325.1 - 3.4e-05 23.5 0.1 0.00029 20.5 0.1 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 CDF88325.1 - 7.2e-05 21.9 0.0 0.00012 21.2 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin Sigma54_activ_2 PF14532.1 CDF88325.1 - 0.00022 21.2 0.0 0.00045 20.2 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_18 PF13238.1 CDF88325.1 - 0.00047 20.4 0.1 0.0015 18.8 0.0 2.0 2 1 0 2 2 1 1 AAA domain IstB_IS21 PF01695.12 CDF88325.1 - 0.00056 19.3 0.0 0.0011 18.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein NACHT PF05729.7 CDF88325.1 - 0.00098 18.8 0.1 0.0033 17.1 0.0 1.9 2 0 0 2 2 2 1 NACHT domain Mg_chelatase PF01078.16 CDF88325.1 - 0.001 18.2 0.3 0.0028 16.8 0.1 1.6 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 CDF88325.1 - 0.0013 18.8 0.0 0.0031 17.6 0.0 1.8 1 0 0 1 1 1 1 RNA helicase AAA_19 PF13245.1 CDF88325.1 - 0.002 17.8 0.2 0.013 15.2 0.0 2.3 2 1 0 2 2 2 1 Part of AAA domain Bac_DnaA PF00308.13 CDF88325.1 - 0.0026 17.4 0.0 0.0051 16.4 0.0 1.5 1 1 0 1 1 1 1 Bacterial dnaA protein AAA_28 PF13521.1 CDF88325.1 - 0.0033 17.3 0.0 0.006 16.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.8 CDF88325.1 - 0.004 16.1 0.0 0.0073 15.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Viral_helicase1 PF01443.13 CDF88325.1 - 0.0043 16.6 0.0 0.0067 15.9 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.1 CDF88325.1 - 0.0048 16.3 0.8 0.16 11.3 0.1 2.5 1 1 0 2 2 2 1 AAA domain AAA_11 PF13086.1 CDF88325.1 - 0.0054 16.3 0.0 0.017 14.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.8 CDF88325.1 - 0.0095 14.6 0.0 0.016 13.9 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus Sigma54_activat PF00158.21 CDF88325.1 - 0.0096 15.4 0.0 0.04 13.3 0.0 1.9 2 0 0 2 2 2 1 Sigma-54 interaction domain ABC_tran PF00005.22 CDF88325.1 - 0.012 15.8 0.0 0.029 14.6 0.0 1.8 1 1 0 1 1 1 0 ABC transporter AAA_3 PF07726.6 CDF88325.1 - 0.014 14.9 0.0 0.039 13.5 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.17 CDF88325.1 - 0.025 13.4 0.0 0.045 12.5 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain Rad17 PF03215.10 CDF88325.1 - 0.037 12.7 0.0 0.071 11.7 0.0 1.4 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein SKI PF01202.17 CDF88325.1 - 0.063 13.1 0.0 0.22 11.4 0.0 1.9 2 0 0 2 2 1 0 Shikimate kinase UPF0079 PF02367.12 CDF88325.1 - 0.079 12.5 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 CPT PF07931.7 CDF88325.1 - 0.079 12.5 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Oxidored_nitro PF00148.14 CDF88325.1 - 0.11 11.0 0.0 8.4 4.9 0.0 2.2 2 0 0 2 2 2 0 Nitrogenase component 1 type Oxidoreductase AAA_24 PF13479.1 CDF88325.1 - 0.13 11.7 0.0 0.29 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.20 CDF88325.1 - 0.14 11.5 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain MA3 PF02847.12 CDF88326.1 - 5.2e-27 93.7 0.0 1.5e-26 92.3 0.0 1.9 1 0 0 1 1 1 1 MA3 domain MIF4G PF02854.14 CDF88326.1 - 4.2e-24 85.1 4.7 4.2e-24 85.1 3.3 2.7 2 1 1 3 3 3 1 MIF4G domain Ran_BP1 PF00638.13 CDF88327.1 - 3.5e-35 120.6 0.1 9.8e-35 119.2 0.1 1.8 1 0 0 1 1 1 1 RanBP1 domain NUP50 PF08911.6 CDF88327.1 - 1.8e-08 34.6 3.5 1.8e-08 34.6 2.4 4.9 4 1 1 5 5 5 1 NUP50 (Nucleoporin 50 kDa) Ribosomal_S25 PF03297.10 CDF88328.1 - 7.9e-45 151.2 4.4 8.8e-45 151.0 3.1 1.0 1 0 0 1 1 1 1 S25 ribosomal protein Ftsk_gamma PF09397.5 CDF88328.1 - 2.1e-05 24.1 0.1 3.1e-05 23.5 0.1 1.2 1 0 0 1 1 1 1 Ftsk gamma domain HTH_CodY PF08222.6 CDF88328.1 - 0.0014 17.9 0.1 0.002 17.4 0.0 1.2 1 0 0 1 1 1 1 CodY helix-turn-helix domain GntR PF00392.16 CDF88328.1 - 0.048 13.1 0.0 0.074 12.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family MerR PF00376.18 CDF88328.1 - 0.057 12.9 0.0 0.096 12.2 0.0 1.4 1 0 0 1 1 1 0 MerR family regulatory protein UPF0121 PF03661.8 CDF88329.1 - 0.00022 20.5 3.3 0.00052 19.2 2.3 1.6 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0121) ABC2_membrane_2 PF12679.2 CDF88329.1 - 0.35 9.6 6.1 1.3 7.7 4.2 1.8 1 1 0 1 1 1 0 ABC-2 family transporter protein Thg1 PF04446.7 CDF88330.1 - 4.9e-45 152.4 0.3 7.8e-45 151.8 0.2 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.1 CDF88330.1 - 1.9e-37 127.6 0.1 3.2e-37 126.9 0.1 1.3 1 0 0 1 1 1 1 Thg1 C terminal domain Xpo1 PF08389.7 CDF88330.1 - 0.0056 16.5 0.1 3.3 7.5 0.0 2.3 2 0 0 2 2 2 2 Exportin 1-like protein WD40 PF00400.27 CDF88331.1 - 0.03 14.1 0.1 0.18 11.7 0.0 2.4 2 0 0 2 2 2 0 WD domain, G-beta repeat Mid2 PF04478.7 CDF88332.1 - 1.8e-59 199.5 0.5 1.8e-59 199.5 0.4 5.5 3 1 4 7 7 7 1 Mid2 like cell wall stress sensor SKG6 PF08693.5 CDF88332.1 - 0.026 13.8 1.7 0.42 9.9 1.1 3.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Transcrip_reg PF01709.15 CDF88333.1 - 8.5e-68 227.9 1.4 1.1e-67 227.6 1.0 1.0 1 0 0 1 1 1 1 Transcriptional regulator DUF4258 PF14076.1 CDF88333.1 - 0.00024 21.0 0.0 0.028 14.3 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4258) SecD-TM1 PF13721.1 CDF88333.1 - 1.4 9.2 3.8 1.4 9.2 0.2 2.1 2 0 0 2 2 2 0 SecD export protein N-terminal TM region ATP-synt_F PF01990.12 CDF88334.1 - 3.3e-28 97.8 0.1 3.8e-28 97.7 0.1 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit BRCT PF00533.21 CDF88335.1 - 1.6e-09 37.8 0.0 7.4e-09 35.6 0.0 2.3 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DUF3006 PF11213.3 CDF88335.1 - 0.0061 16.2 1.0 0.021 14.5 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3006) fn3 PF00041.16 CDF88335.1 - 0.0069 16.4 0.0 0.024 14.7 0.0 1.9 1 0 0 1 1 1 1 Fibronectin type III domain PTCB-BRCT PF12738.2 CDF88335.1 - 0.018 14.9 0.0 0.037 13.8 0.0 1.6 1 0 0 1 1 1 0 twin BRCT domain Aminotran_3 PF00202.16 CDF88336.1 - 1.6e-86 290.2 0.0 2e-86 289.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Pyridox_oxase_2 PF12766.2 CDF88337.1 - 5.1e-31 106.9 0.0 1e-30 106.0 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxidase PF01243.15 CDF88337.1 - 0.026 14.5 0.0 0.086 12.8 0.0 1.8 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Ribonuc_red_sm PF00268.16 CDF88338.1 - 9.5e-121 402.1 3.4 1.2e-120 401.7 2.3 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain STN1_2 PF09170.5 CDF88338.1 - 0.1 12.3 0.2 0.21 11.3 0.2 1.5 1 0 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 MFS_1 PF07690.11 CDF88339.1 - 9.9e-38 129.7 34.1 4.5e-37 127.5 19.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 CDF88339.1 - 7.8e-08 30.9 1.2 1.2e-07 30.4 0.8 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.19 CDF88339.1 - 1.7e-06 26.9 27.1 3.4e-06 25.9 18.8 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter ESSS PF10183.4 CDF88339.1 - 0.41 11.0 5.7 0.52 10.7 0.0 3.4 4 0 0 4 4 4 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) CENP-Q PF13094.1 CDF88340.1 - 2.1 8.3 11.2 0.091 12.7 2.9 2.3 2 1 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit LsmAD PF06741.8 CDF88341.1 - 4.7e-28 97.0 1.6 4.7e-28 97.0 1.1 2.7 2 0 0 2 2 2 1 LsmAD domain SM-ATX PF14438.1 CDF88341.1 - 1.7e-15 56.7 0.0 5.2e-15 55.1 0.0 1.9 1 0 0 1 1 1 1 Ataxin 2 SM domain RRN7 PF11781.3 CDF88342.1 - 8.1e-11 41.2 0.1 1.4e-10 40.4 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase I-specific transcription initiation factor Rrn7 SAM_PNT PF02198.11 CDF88342.1 - 0.06 13.1 2.4 0.64 9.8 0.1 2.5 2 0 0 2 2 2 0 Sterile alpha motif (SAM)/Pointed domain ETRAMP PF09716.5 CDF88342.1 - 0.079 12.9 0.0 1.7 8.6 0.0 2.7 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) SE PF08491.5 CDF88343.1 - 1.2e-121 404.7 0.0 1.6e-121 404.3 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.14 CDF88343.1 - 1.2e-13 50.8 0.0 2.4e-13 49.8 0.0 1.4 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 CDF88343.1 - 8.3e-08 31.5 0.1 4.5e-05 22.5 0.1 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CDF88343.1 - 0.00034 20.5 0.1 0.00098 19.0 0.0 1.8 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CDF88343.1 - 0.00074 19.8 0.6 0.0021 18.4 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CDF88343.1 - 0.0018 17.1 2.0 0.0099 14.7 0.4 2.0 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.1 CDF88343.1 - 0.0032 17.4 0.1 0.0071 16.3 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.13 CDF88343.1 - 0.0046 16.6 0.2 0.0072 15.9 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 CDF88343.1 - 0.0096 16.0 0.1 0.02 14.9 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Thi4 PF01946.12 CDF88343.1 - 0.02 13.9 0.2 0.035 13.2 0.2 1.3 1 0 0 1 1 1 0 Thi4 family F420_oxidored PF03807.12 CDF88343.1 - 0.021 15.2 0.1 0.044 14.2 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent UDPG_MGDP_dh_N PF03721.9 CDF88343.1 - 0.028 13.8 0.1 0.28 10.5 0.0 2.1 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.13 CDF88343.1 - 0.035 14.0 0.1 0.083 12.8 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain NAD_Gly3P_dh_N PF01210.18 CDF88343.1 - 0.059 13.0 0.1 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DUF2773 PF10971.3 CDF88343.1 - 0.07 13.1 0.0 0.93 9.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2773) GIDA PF01134.17 CDF88343.1 - 0.094 11.5 0.7 0.45 9.3 0.1 2.0 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_oxidored PF12831.2 CDF88343.1 - 0.23 10.5 2.1 0.29 10.1 0.4 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.9 CDF88343.1 - 0.24 9.7 0.6 0.63 8.4 0.1 1.7 2 0 0 2 2 2 0 HI0933-like protein CBP4 PF07960.6 CDF88344.1 - 4.1e-47 158.9 3.8 4.7e-47 158.7 2.6 1.0 1 0 0 1 1 1 1 CBP4 DUF3419 PF11899.3 CDF88344.1 - 0.066 11.9 0.1 0.076 11.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3419) UPF0449 PF15136.1 CDF88344.1 - 0.11 12.7 1.7 0.15 12.3 0.4 1.8 1 1 0 2 2 2 0 Uncharacterised protein family UPF0449 Troponin PF00992.15 CDF88344.1 - 0.23 11.5 6.5 0.66 10.0 0.9 2.1 2 0 0 2 2 2 0 Troponin DrrA_P4M PF14860.1 CDF88344.1 - 0.25 11.1 3.3 0.22 11.2 0.8 1.8 1 1 1 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain LAMTOR PF15454.1 CDF88344.1 - 0.46 10.7 9.8 0.75 10.1 0.4 2.3 1 1 1 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Elongin_A PF06881.6 CDF88344.1 - 0.49 10.8 6.1 1.1 9.6 3.2 1.9 1 1 1 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Clat_adaptor_s PF01217.15 CDF88345.1 - 5.4e-57 191.5 1.4 6.4e-57 191.2 1.0 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain TFIID_20kDa PF03847.8 CDF88345.1 - 0.034 14.4 2.0 0.3 11.4 0.0 2.6 3 0 0 3 3 3 0 Transcription initiation factor TFIID subunit A zf-Tim10_DDP PF02953.10 CDF88346.1 - 1.3e-17 62.8 1.4 1.8e-17 62.3 1.0 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Cap_synth_GfcB PF11102.3 CDF88346.1 - 0.0093 15.5 0.1 0.012 15.1 0.0 1.1 1 0 0 1 1 1 1 Group 4 capsule polysaccharide formation lipoprotein gfcB DUF3398 PF11878.3 CDF88346.1 - 0.024 14.4 0.6 0.034 13.9 0.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3398) DUF4280 PF14107.1 CDF88346.1 - 0.037 14.3 0.5 0.043 14.1 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4280) UCR_UQCRX_QCR9 PF05365.7 CDF88347.1 - 1.9e-25 88.2 0.6 2.1e-25 88.1 0.4 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like ATPase-cat_bd PF12156.3 CDF88347.1 - 0.015 15.8 0.0 0.02 15.4 0.0 1.1 1 0 0 1 1 1 0 Putative metal-binding domain of cation transport ATPase zf-UBR PF02207.15 CDF88348.1 - 1e-15 57.2 14.5 1e-15 57.2 10.0 2.5 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.12 CDF88348.1 - 4e-09 36.0 0.0 9.9e-09 34.8 0.0 1.7 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS zf-RING_2 PF13639.1 CDF88348.1 - 0.00028 20.6 1.1 0.00028 20.6 0.7 3.4 3 0 0 3 3 3 1 Ring finger domain zf-UBR PF02207.15 CDF88349.1 - 2.7e-13 49.4 9.9 2.7e-13 49.4 6.8 2.6 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) tRNA-synt_1b PF00579.20 CDF88350.1 - 4.2e-75 252.5 0.0 5.1e-75 252.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TFIIF_alpha PF05793.7 CDF88351.1 - 9.7e-13 47.3 46.9 4.9e-10 38.4 0.3 3.4 2 1 1 3 3 3 3 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF383 PF04063.9 CDF88352.1 - 1.1e-68 230.6 1.8 1.7e-68 229.9 0.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF383) DUF384 PF04064.8 CDF88352.1 - 1.8e-25 88.2 0.2 5.3e-25 86.7 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF384) PapB PF03333.8 CDF88352.1 - 0.058 13.2 0.3 0.21 11.4 0.0 2.0 2 0 0 2 2 2 0 Adhesin biosynthesis transcription regulatory protein PUF PF00806.14 CDF88353.1 - 2.1e-55 181.2 10.5 1.8e-07 30.2 0.0 8.6 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat HlyIII PF03006.15 CDF88354.1 - 3.6e-66 222.7 20.1 4.5e-66 222.4 13.9 1.1 1 0 0 1 1 1 1 Haemolysin-III related SBDS_C PF09377.5 CDF88355.1 - 1.8e-35 121.3 3.4 2.2e-35 121.0 0.9 1.9 2 0 0 2 2 2 1 SBDS protein C-terminal domain SBDS PF01172.13 CDF88355.1 - 1.7e-33 114.2 1.4 2.8e-33 113.5 1.0 1.4 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein chaperone_DMP PF10448.4 CDF88356.1 - 1.1e-33 116.1 0.0 1.3e-33 115.9 0.0 1.0 1 0 0 1 1 1 1 20S proteasome chaperone Abhydro_lipase PF04083.11 CDF88357.1 - 1.2e-16 59.8 0.1 2.2e-16 58.9 0.1 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.15 CDF88357.1 - 0.00012 21.7 0.0 0.00027 20.5 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CDF88357.1 - 0.0011 18.9 0.0 0.0016 18.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF900 PF05990.7 CDF88357.1 - 0.081 12.2 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) WD40 PF00400.27 CDF88358.1 - 1.5e-37 126.1 2.6 8e-08 31.8 0.0 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat Sof1 PF04158.9 CDF88358.1 - 3e-28 97.6 15.0 7.3e-28 96.4 10.4 1.7 1 0 0 1 1 1 1 Sof1-like domain BBS2_Mid PF14783.1 CDF88358.1 - 0.00025 20.7 0.8 0.01 15.6 0.1 3.4 4 1 0 4 4 4 1 Ciliary BBSome complex subunit 2, middle region DUF3340 PF11818.3 CDF88358.1 - 3.1 7.7 10.6 8.9 6.2 7.3 1.9 1 0 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) NPCC PF08058.6 CDF88359.1 - 4.1e-30 104.5 0.2 6.8e-30 103.8 0.1 1.3 1 0 0 1 1 1 1 Nuclear pore complex component PNP_UDP_1 PF01048.15 CDF88360.1 - 2e-32 112.0 0.0 2.5e-32 111.7 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily COX17 PF05051.8 CDF88361.1 - 3.8e-21 74.8 7.7 4.1e-21 74.7 5.3 1.0 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) CHCH PF06747.8 CDF88361.1 - 5.7e-05 22.9 4.4 7.6e-05 22.5 3.1 1.3 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.5 CDF88361.1 - 0.0033 17.1 0.2 0.0033 17.1 0.2 1.9 1 1 1 2 2 2 1 Cytochrome c oxidase biogenesis protein Cmc1 like zf-AD PF07776.10 CDF88361.1 - 0.08 12.9 2.3 0.09 12.7 1.6 1.0 1 0 0 1 1 1 0 Zinc-finger associated domain (zf-AD) Endonuc-dimeris PF09124.5 CDF88361.1 - 0.25 11.0 1.6 0.4 10.3 1.1 1.5 1 1 0 1 1 1 0 T4 recombination endonuclease VII, dimerisation UPF0203 PF05254.7 CDF88361.1 - 0.78 9.6 5.2 2.2 8.1 3.6 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) PP2C PF00481.16 CDF88362.1 - 1.5e-51 175.3 0.0 1.5e-51 175.3 0.0 2.2 2 0 0 2 2 2 1 Protein phosphatase 2C LRR_4 PF12799.2 CDF88362.1 - 2.3e-43 145.1 80.8 1.6e-06 27.5 0.2 11.9 7 2 4 12 12 12 11 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CDF88362.1 - 5.6e-35 118.9 81.1 2.9e-09 36.5 5.2 9.7 5 3 5 10 10 10 8 Leucine rich repeat Guanylate_cyc PF00211.15 CDF88362.1 - 7.4e-29 100.4 0.0 1.6e-28 99.3 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain LRR_1 PF00560.28 CDF88362.1 - 6.3e-14 49.8 80.0 0.048 13.7 0.6 18.8 15 3 1 16 16 16 7 Leucine Rich Repeat RA PF00788.18 CDF88362.1 - 5.3e-08 33.2 0.1 2.1e-07 31.2 0.0 2.1 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Ad_cyc_g-alpha PF08509.6 CDF88362.1 - 0.00018 20.7 0.0 0.00055 19.2 0.0 1.8 1 0 0 1 1 1 1 Adenylate cyclase G-alpha binding domain LRR_7 PF13504.1 CDF88362.1 - 0.0099 15.9 70.5 1.2 9.6 0.4 17.1 19 0 0 19 19 19 1 Leucine rich repeat LRR_9 PF14580.1 CDF88362.1 - 0.091 12.3 20.2 0.2 11.1 1.3 4.2 2 1 2 4 4 4 0 Leucine-rich repeat LRR_6 PF13516.1 CDF88362.1 - 9 6.7 85.3 4.5 7.6 0.2 16.9 16 3 3 19 19 19 0 Leucine Rich repeat SYS1 PF09801.4 CDF88363.1 - 6.5e-48 162.4 16.0 7.7e-48 162.1 11.1 1.1 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network DEAD PF00270.24 CDF88364.1 - 1.2e-45 155.0 0.1 2.7e-45 153.9 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF88364.1 - 2e-26 91.6 0.2 9e-26 89.5 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF2404 PF10296.4 CDF88366.1 - 3.9e-05 23.6 0.0 0.00012 22.1 0.0 1.9 2 0 0 2 2 2 1 Putative integral membrane protein conserved region (DUF2404) DUF2895 PF11444.3 CDF88366.1 - 0.011 15.0 0.1 0.018 14.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2895) DUF221 PF02714.10 CDF88367.1 - 4.2e-89 298.6 25.0 4.2e-89 298.6 17.4 2.5 3 0 0 3 3 3 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 CDF88367.1 - 2.1e-29 102.1 4.0 2.1e-29 102.1 2.8 2.9 3 1 1 4 4 4 1 Late exocytosis, associated with Golgi transport DUF3779 PF12621.3 CDF88367.1 - 5e-09 35.9 0.0 1e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 Phosphate metabolism protein COX16 PF14138.1 CDF88368.1 - 2.6e-28 97.9 0.8 3.4e-28 97.6 0.1 1.5 2 0 0 2 2 2 1 Cytochrome c oxidase assembly protein COX16 Ribophorin_I PF04597.9 CDF88370.1 - 3.5e-123 411.3 0.1 3.9e-123 411.1 0.0 1.0 1 0 0 1 1 1 1 Ribophorin I Sfi1 PF08457.5 CDF88371.1 - 2.4e-32 112.0 70.3 2.3e-28 98.9 36.3 2.6 1 1 2 3 3 3 3 Sfi1 spindle body protein Sfi1_C PF10638.4 CDF88371.1 - 1e-27 96.6 3.2 2.6e-27 95.3 2.2 1.6 1 0 0 1 1 1 1 Spindle body associated protein C-terminus Proteasome PF00227.21 CDF88372.1 - 1.7e-49 167.7 1.8 1.9e-49 167.5 1.2 1.0 1 0 0 1 1 1 1 Proteasome subunit EMG1 PF03587.9 CDF88372.1 - 0.13 11.5 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 EMG1/NEP1 methyltransferase KAT11 PF08214.6 CDF88373.1 - 9.8e-91 304.3 0.2 1.2e-90 304.1 0.2 1.0 1 0 0 1 1 1 1 Histone acetylation protein Dynamin_M PF01031.15 CDF88374.1 - 3.9e-111 370.5 0.0 6.8e-111 369.7 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.18 CDF88374.1 - 3.7e-54 183.0 2.6 6.8e-54 182.1 0.0 2.4 2 1 0 2 2 2 1 Dynamin family GED PF02212.13 CDF88374.1 - 3.3e-29 100.6 2.3 3.3e-29 100.6 1.6 2.0 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 CDF88374.1 - 0.00058 19.8 0.3 0.0078 16.1 0.2 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CDF88374.1 - 0.014 15.8 0.0 0.076 13.5 0.0 2.2 2 0 0 2 2 2 0 Miro-like protein BSMAP PF12280.3 CDF88374.1 - 0.022 14.6 0.4 0.052 13.4 0.3 1.6 1 0 0 1 1 1 0 Brain specific membrane anchored protein zf-CCHC_4 PF14392.1 CDF88374.1 - 0.1 12.3 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Zinc knuckle Fasciclin PF02469.17 CDF88375.1 - 2.6e-18 66.2 0.5 7.2e-07 29.2 0.0 6.1 6 2 0 6 6 6 4 Fasciclin domain SKG6 PF08693.5 CDF88375.1 - 0.087 12.1 3.7 0.2 11.0 2.5 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Aa_trans PF01490.13 CDF88376.1 - 6.4e-82 275.2 17.4 7.8e-82 274.9 12.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 CDF88376.1 - 0.0036 16.1 3.7 0.0036 16.1 2.6 2.3 2 0 0 2 2 2 2 Tryptophan/tyrosine permease family Mpp10 PF04006.7 CDF88377.1 - 1.9e-121 406.3 55.7 3.9e-121 405.3 38.6 1.4 1 1 0 1 1 1 1 Mpp10 protein DnaI_N PF07319.6 CDF88377.1 - 6.6 7.0 12.9 0.82 9.9 0.7 3.5 4 0 0 4 4 4 0 Primosomal protein DnaI N-terminus CBF PF03914.12 CDF88378.1 - 1.3e-38 132.0 0.1 3.9e-38 130.4 0.1 1.9 1 0 0 1 1 1 1 CBF/Mak21 family NOC3p PF07540.6 CDF88378.1 - 4.8e-33 113.2 0.1 4.8e-33 113.2 0.1 4.0 4 0 0 4 4 4 1 Nucleolar complex-associated protein TIMELESS PF04821.9 CDF88378.1 - 0.0054 16.0 3.0 0.015 14.5 2.1 1.7 1 0 0 1 1 1 1 Timeless protein 60KD_IMP PF02096.15 CDF88378.1 - 0.2 11.3 3.8 0.43 10.2 2.6 1.5 1 0 0 1 1 1 0 60Kd inner membrane protein Candida_ALS_N PF11766.3 CDF88381.1 - 1.4e-66 223.8 5.9 1.4e-66 223.8 4.1 2.6 2 0 0 2 2 2 1 Cell-wall agglutinin N-terminal ligand-sugar binding Flocculin PF00624.13 CDF88381.1 - 8.4e-14 51.1 54.3 7.1e-10 38.5 15.6 10.6 10 3 3 13 13 13 2 Flocculin repeat Adaptin_N PF01602.15 CDF88382.1 - 2.2e-92 310.1 16.9 2.6e-92 309.8 11.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 CDF88382.1 - 1.1e-07 32.0 5.3 0.0041 17.3 0.0 3.8 2 1 2 4 4 4 2 HEAT repeats Arm PF00514.18 CDF88382.1 - 0.0047 16.7 0.1 19 5.2 0.0 4.0 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat DUF2435 PF10363.4 CDF88382.1 - 0.024 14.5 0.5 0.024 14.5 0.3 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF2435) VHS PF00790.14 CDF88382.1 - 0.42 10.2 3.9 3.6 7.2 0.1 3.9 5 0 0 5 5 5 0 VHS domain CMS1 PF14617.1 CDF88383.1 - 7.5e-16 57.9 10.8 3.2e-15 55.8 7.5 1.9 1 1 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit VitD-bind_III PF09164.5 CDF88383.1 - 0.031 13.8 0.1 0.33 10.5 0.0 2.8 2 1 1 3 3 3 0 Vitamin D binding protein, domain III PBP_sp32 PF07222.7 CDF88383.1 - 1.6 7.8 6.8 2.6 7.1 4.7 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 MFS_1 PF07690.11 CDF88384.1 - 2.4e-34 118.5 23.3 2.1e-33 115.5 16.9 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily Ssl1 PF04056.9 CDF88385.1 - 3.6e-83 277.8 0.0 4.8e-83 277.4 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.7 CDF88385.1 - 2e-21 75.7 11.9 2e-21 75.7 8.2 2.8 2 0 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.1 CDF88385.1 - 1.7e-10 41.2 0.0 2.5e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Taeniidae_ag PF05596.6 CDF88385.1 - 0.041 13.6 0.0 0.092 12.5 0.0 1.6 1 0 0 1 1 1 0 Taeniidae antigen VWA PF00092.23 CDF88385.1 - 0.13 11.9 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 von Willebrand factor type A domain CDC45 PF02724.9 CDF88385.1 - 8.4 4.2 12.1 11 3.8 8.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Response_reg PF00072.19 CDF88386.1 - 2.2e-20 72.7 0.0 8.6e-14 51.4 0.0 2.4 2 0 0 2 2 2 2 Response regulator receiver domain Reo_sigmaC PF04582.7 CDF88387.1 - 0.069 12.3 29.5 0.17 10.9 0.7 4.7 1 1 4 5 5 5 0 Reovirus sigma C capsid protein ApoO PF09769.4 CDF88387.1 - 0.19 11.4 4.7 0.85 9.3 0.1 2.9 2 1 1 3 3 3 0 Apolipoprotein O DUF869 PF05911.6 CDF88387.1 - 0.24 9.6 58.8 0.95 7.6 15.4 3.0 1 1 2 3 3 3 0 Plant protein of unknown function (DUF869) DUF972 PF06156.8 CDF88387.1 - 0.77 10.1 60.5 0.65 10.3 2.3 7.2 2 1 6 8 8 8 0 Protein of unknown function (DUF972) IncA PF04156.9 CDF88387.1 - 0.78 9.2 65.6 2.4 7.6 6.9 5.0 1 1 3 4 4 4 0 IncA protein DUF4201 PF13870.1 CDF88387.1 - 1.8 7.9 63.6 0.52 9.7 5.2 5.7 1 1 5 6 6 6 0 Domain of unknown function (DUF4201) MbeD_MobD PF04899.7 CDF88387.1 - 1.9 8.4 14.7 4.4 7.2 0.1 4.8 5 1 0 5 5 5 0 MbeD/MobD like CENP-F_leu_zip PF10473.4 CDF88387.1 - 2.4 8.0 72.0 0.029 14.2 7.2 5.8 1 1 5 6 6 6 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Matrilin_ccoil PF10393.4 CDF88387.1 - 2.5 7.5 12.5 1.1 8.6 0.1 5.1 4 1 0 4 4 4 0 Trimeric coiled-coil oligomerisation domain of matrilin PspA_IM30 PF04012.7 CDF88387.1 - 7.6 5.8 52.2 0.19 11.0 8.0 4.9 1 1 3 4 4 4 0 PspA/IM30 family ADIP PF11559.3 CDF88387.1 - 9.6 6.0 65.8 0.38 10.6 5.7 5.7 1 1 3 5 5 5 0 Afadin- and alpha -actinin-Binding SMC_Nse1 PF07574.8 CDF88388.1 - 6.3e-46 156.5 0.2 7.6e-46 156.2 0.1 1.1 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.6 CDF88388.1 - 1.5e-08 34.4 13.7 1.5e-08 34.4 9.5 2.2 2 0 0 2 2 2 1 RING-like domain Chordopox_A30L PF06015.7 CDF88388.1 - 0.0002 20.8 0.3 0.00041 19.9 0.2 1.5 1 0 0 1 1 1 1 Chordopoxvirus A30L protein DUF2610 PF11020.3 CDF88388.1 - 0.088 12.6 0.1 6 6.7 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF2610) Lipase_3 PF01764.20 CDF88388.1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) PHD PF00628.24 CDF88388.1 - 1.1 8.9 11.4 3.6 7.3 7.9 1.9 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.1 CDF88388.1 - 1.4 8.7 8.5 3.9 7.2 5.9 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 DnaJ PF00226.26 CDF88389.1 - 2.6e-06 27.0 0.1 3.8e-06 26.5 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.8 CDF88389.1 - 3.1e-06 26.9 0.1 4e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Pam16 Ribosomal_L24e PF01246.15 CDF88390.1 - 4.5e-29 100.0 1.8 4.5e-29 100.0 1.2 2.0 2 0 0 2 2 2 1 Ribosomal protein L24e Nucleoplasmin PF03066.10 CDF88390.1 - 1.4 8.4 12.6 2.1 7.8 8.7 1.2 1 0 0 1 1 1 0 Nucleoplasmin TRAP_alpha PF03896.11 CDF88390.1 - 3.9 6.3 8.2 5.9 5.7 5.7 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit YqfQ PF14181.1 CDF88390.1 - 4.6 7.2 9.5 7.7 6.5 6.6 1.3 1 0 0 1 1 1 0 YqfQ-like protein GOLD_2 PF13897.1 CDF88390.1 - 5.4 7.2 7.5 35 4.6 0.0 2.3 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking GCD14 PF08704.5 CDF88391.1 - 0.0058 16.1 0.0 4.9 6.5 0.0 2.8 3 0 0 3 3 3 2 tRNA methyltransferase complex GCD14 subunit LrgA PF03788.9 CDF88391.1 - 0.14 11.8 0.1 0.24 11.1 0.1 1.3 1 0 0 1 1 1 0 LrgA family GCFC PF07842.7 CDF88392.1 - 0.05 12.9 0.0 0.067 12.5 0.0 1.1 1 0 0 1 1 1 0 GC-rich sequence DNA-binding factor-like protein NMT1 PF09084.6 CDF88393.1 - 1.8e-74 249.9 0.0 2.2e-74 249.6 0.0 1.1 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.1 CDF88393.1 - 2.1e-07 30.5 0.2 0.011 15.1 0.1 2.3 2 1 0 2 2 2 2 NMT1-like family 2Fe-2S_thioredx PF01257.14 CDF88393.1 - 0.0038 16.8 1.0 0.0065 16.0 0.7 1.3 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin Phosphonate-bd PF12974.2 CDF88393.1 - 0.035 13.4 0.0 0.053 12.8 0.0 1.2 1 0 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein Fungal_trans PF04082.13 CDF88394.1 - 1.9e-43 148.2 0.7 1.4e-42 145.3 0.5 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF88394.1 - 1.4e-09 37.6 12.8 2.5e-09 36.8 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SPRY PF00622.23 CDF88395.1 - 0.00017 21.6 0.0 0.0073 16.3 0.0 2.6 2 0 0 2 2 2 1 SPRY domain Prefoldin PF02996.12 CDF88395.1 - 0.0037 16.9 2.3 0.0081 15.8 1.6 1.5 1 0 0 1 1 1 1 Prefoldin subunit FHA PF00498.21 CDF88395.1 - 0.015 15.4 0.0 0.9 9.7 0.0 2.7 2 0 0 2 2 2 0 FHA domain Ten_N PF06484.7 CDF88395.1 - 0.062 12.3 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 Teneurin Intracellular Region PX PF00787.19 CDF88396.1 - 3.6e-24 84.7 1.1 8.1e-24 83.6 0.2 2.1 2 0 0 2 2 2 1 PX domain Vps5 PF09325.5 CDF88396.1 - 0.00017 20.9 14.8 0.0014 17.9 2.7 2.4 2 0 0 2 2 2 2 Vps5 C terminal like Atg14 PF10186.4 CDF88396.1 - 0.011 14.6 8.7 0.17 10.7 0.7 2.2 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DUF2937 PF11157.3 CDF88396.1 - 0.039 13.2 0.3 0.11 11.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) FlaC_arch PF05377.6 CDF88396.1 - 0.048 13.5 7.2 2.4 8.1 0.1 3.8 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) Nup54 PF13874.1 CDF88396.1 - 0.16 11.5 1.8 0.68 9.5 0.1 2.5 2 1 1 3 3 3 0 Nucleoporin complex subunit 54 IncA PF04156.9 CDF88396.1 - 0.17 11.4 13.0 0.12 11.9 2.2 2.6 2 1 0 2 2 2 0 IncA protein NPV_P10 PF05531.7 CDF88396.1 - 0.2 11.8 4.6 25 5.2 1.7 3.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein COG2 PF06148.6 CDF88396.1 - 0.37 10.6 9.5 0.16 11.8 2.3 2.9 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 bZIP_1 PF00170.16 CDF88396.1 - 0.4 10.6 9.5 13 5.8 0.9 3.8 2 1 1 3 3 3 0 bZIP transcription factor DUF972 PF06156.8 CDF88396.1 - 1.1 9.6 11.8 0.18 12.1 1.1 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF972) DUF1664 PF07889.7 CDF88396.1 - 2.4 7.9 8.4 8.3 6.2 1.2 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) YlqD PF11068.3 CDF88396.1 - 2.8 8.0 9.3 0.32 11.0 1.5 2.5 1 1 1 2 2 2 0 YlqD protein DUF3552 PF12072.3 CDF88396.1 - 5.1 6.2 12.4 2.9 7.0 2.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) IZUMO PF15005.1 CDF88396.1 - 6.1 6.8 7.2 1.2 9.1 1.0 2.5 3 0 0 3 3 3 0 Izumo sperm-egg fusion dCMP_cyt_deam_1 PF00383.17 CDF88397.1 - 5.8e-20 70.8 0.0 8.7e-20 70.2 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region APOBEC_N PF08210.6 CDF88397.1 - 0.0081 15.7 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 APOBEC-like N-terminal domain Bd3614-deam PF14439.1 CDF88397.1 - 0.022 14.5 0.2 0.092 12.5 0.1 1.8 1 1 1 2 2 2 0 Bd3614-like deaminase BNR_assoc_N PF14873.1 CDF88398.1 - 0.016 15.0 0.4 0.38 10.5 0.0 2.5 2 1 0 2 2 2 0 N-terminal domain of BNR-repeat neuraminidase HSP70 PF00012.15 CDF88399.1 - 7.6e-266 882.7 11.8 8.7e-266 882.6 8.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 CDF88399.1 - 1.6e-18 66.4 2.1 3.6e-17 61.9 0.3 2.1 2 0 0 2 2 2 2 MreB/Mbl protein Hydantoinase_A PF01968.13 CDF88399.1 - 0.004 16.2 5.8 0.048 12.7 0.0 3.5 3 1 1 4 4 4 1 Hydantoinase/oxoprolinase Enolase_N PF03952.11 CDF88399.1 - 0.0046 16.9 0.4 0.43 10.5 0.0 2.6 2 0 0 2 2 2 1 Enolase, N-terminal domain BcrAD_BadFG PF01869.15 CDF88399.1 - 0.017 14.4 0.0 0.18 11.0 0.0 2.3 1 1 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family FGGY_C PF02782.11 CDF88399.1 - 0.041 13.5 0.0 0.36 10.4 0.0 2.3 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain Secretin_N PF03958.12 CDF88399.1 - 0.044 13.9 0.4 3.1 8.0 0.0 3.1 3 0 0 3 3 3 0 Bacterial type II/III secretion system short domain FtsA PF14450.1 CDF88399.1 - 0.087 12.6 6.1 0.4 10.5 0.0 3.4 3 1 0 3 3 3 0 Cell division protein FtsA FHA PF00498.21 CDF88400.1 - 4.8e-15 55.4 0.0 9.6e-15 54.4 0.0 1.5 1 0 0 1 1 1 1 FHA domain DEAD PF00270.24 CDF88401.1 - 1.7e-42 144.7 0.0 1.1e-41 142.1 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF4217 PF13959.1 CDF88401.1 - 1.1e-24 85.7 0.1 2.3e-24 84.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.26 CDF88401.1 - 3.4e-23 81.2 0.0 1e-22 79.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DsrH PF04077.7 CDF88401.1 - 0.061 13.0 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 DsrH like protein Cyclin_N PF00134.18 CDF88402.1 - 4.3e-12 45.7 0.8 8.2e-12 44.7 0.6 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain TFIIB PF00382.14 CDF88402.1 - 0.00087 19.0 0.0 0.0017 18.1 0.0 1.4 1 0 0 1 1 1 1 Transcription factor TFIIB repeat HORMA PF02301.13 CDF88403.1 - 1.2e-42 145.7 0.1 1.3e-42 145.6 0.1 1.0 1 0 0 1 1 1 1 HORMA domain DUF4279 PF14106.1 CDF88403.1 - 0.0067 16.2 0.0 0.25 11.2 0.0 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4279) DUF1682 PF07946.9 CDF88403.1 - 0.016 14.0 0.1 0.019 13.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Vps53_N PF04100.7 CDF88404.1 - 6.3e-87 291.8 15.7 1.1e-86 291.0 10.9 1.3 1 0 0 1 1 1 1 Vps53-like, N-terminal MCPsignal PF00015.16 CDF88404.1 - 0.42 10.1 5.8 0.42 10.1 1.0 2.8 3 1 1 4 4 4 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF3724 PF12521.3 CDF88404.1 - 1.5 8.6 4.1 0.39 10.5 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3724) Cpn60_TCP1 PF00118.19 CDF88405.1 - 3.3e-130 434.9 8.1 3.8e-130 434.7 5.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PUF PF00806.14 CDF88406.1 - 2.3e-35 118.0 4.7 0.00023 20.4 0.0 8.6 8 0 0 8 8 8 7 Pumilio-family RNA binding repeat CBF PF03914.12 CDF88406.1 - 0.11 11.9 2.2 0.93 8.9 0.1 2.8 3 0 0 3 3 3 0 CBF/Mak21 family DUF3294 PF07957.6 CDF88407.1 - 6.4e-79 264.4 1.5 7.1e-79 264.3 1.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3294) AF0941-like PF14591.1 CDF88407.1 - 0.84 9.7 6.5 4.1 7.4 0.1 3.2 2 2 1 3 3 3 0 AF0941-like RNA_pol_Rbc25 PF08292.7 CDF88408.1 - 8.3e-44 148.6 0.1 1.1e-43 148.2 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.12 CDF88408.1 - 6.2e-20 71.0 0.0 8.8e-20 70.6 0.0 1.2 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.18 CDF88408.1 - 0.021 14.8 0.0 0.045 13.8 0.0 1.6 1 1 0 1 1 1 0 S1 RNA binding domain AAA PF00004.24 CDF88409.1 - 2.2e-40 137.9 0.0 6.3e-40 136.4 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CDF88409.1 - 4.5e-06 26.8 0.0 0.001 19.2 0.0 2.6 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.9 CDF88409.1 - 2.6e-05 23.9 0.0 0.00012 21.7 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 CDF88409.1 - 0.00015 21.8 0.0 0.0007 19.6 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.9 CDF88409.1 - 0.0002 21.3 0.0 0.00058 19.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_17 PF13207.1 CDF88409.1 - 0.00079 20.2 0.1 0.003 18.3 0.0 2.1 2 1 0 2 2 1 1 AAA domain DUF815 PF05673.8 CDF88409.1 - 0.00099 18.1 0.0 0.0017 17.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.7 CDF88409.1 - 0.0029 16.6 0.0 0.0054 15.8 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 CDF88409.1 - 0.0061 16.2 0.1 0.012 15.3 0.1 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_28 PF13521.1 CDF88409.1 - 0.0091 15.9 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 CDF88409.1 - 0.011 15.6 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 CDF88409.1 - 0.014 14.4 0.0 0.024 13.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.1 CDF88409.1 - 0.017 14.9 0.0 0.037 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 CDF88409.1 - 0.022 15.0 0.1 0.062 13.5 0.0 1.8 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.17 CDF88409.1 - 0.023 14.8 0.0 0.059 13.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.12 CDF88409.1 - 0.03 13.7 0.0 0.052 12.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_3 PF07726.6 CDF88409.1 - 0.034 13.7 0.0 0.063 12.8 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.1 CDF88409.1 - 0.036 14.1 0.0 0.075 13.0 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Mg_chelatase PF01078.16 CDF88409.1 - 0.044 12.9 0.0 0.11 11.6 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.8 CDF88409.1 - 0.047 12.4 0.0 0.078 11.6 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus AAA_24 PF13479.1 CDF88409.1 - 0.087 12.3 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain Arch_ATPase PF01637.13 CDF88409.1 - 0.16 11.6 0.9 4.9 6.7 0.0 2.6 2 1 1 3 3 3 0 Archaeal ATPase Aa_trans PF01490.13 CDF88410.1 - 1.5e-87 293.7 31.8 1.7e-87 293.5 22.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Claudin_2 PF13903.1 CDF88410.1 - 0.038 13.6 6.3 0.47 10.1 0.0 2.9 2 1 1 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction HSP70 PF00012.15 CDF88411.1 - 6.6e-177 589.0 2.4 6.6e-177 589.0 1.7 2.1 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.8 CDF88411.1 - 3.2e-10 39.1 0.0 9e-10 37.6 0.0 1.6 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.1 CDF88411.1 - 5.1e-06 26.3 2.0 0.00065 19.5 0.3 3.6 2 2 0 2 2 2 1 Cell division protein FtsA Ketoacyl-synt_C PF02801.17 CDF88411.1 - 0.052 13.3 0.0 0.16 11.8 0.0 1.8 2 0 0 2 2 2 0 Beta-ketoacyl synthase, C-terminal domain Endonuc_Holl PF10107.4 CDF88411.1 - 3.2 7.4 9.3 0.16 11.6 0.3 2.4 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase Oxidored-like PF09791.4 CDF88412.1 - 2e-26 91.1 1.7 4.4e-26 90.0 1.2 1.6 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal DUF2217 PF10265.4 CDF88412.1 - 0.034 12.9 7.2 0.041 12.6 5.0 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2217) RR_TM4-6 PF06459.7 CDF88412.1 - 9.2 6.0 13.2 12 5.7 9.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pex24p PF06398.6 CDF88413.1 - 3.4e-39 134.6 5.5 4e-39 134.4 3.8 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Rpp20 PF12328.3 CDF88414.1 - 9.8e-26 90.1 4.1 1.2e-23 83.3 2.8 2.2 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.16 CDF88414.1 - 3.3e-14 52.2 0.1 6.3e-14 51.3 0.1 1.5 1 0 0 1 1 1 1 Alba NifQ PF04891.7 CDF88415.1 - 0.088 12.9 0.2 0.31 11.1 0.0 1.9 1 1 1 2 2 2 0 NifQ Ureidogly_hydro PF04115.7 CDF88416.1 - 7.6e-46 155.4 0.0 8.8e-46 155.2 0.0 1.0 1 0 0 1 1 1 1 Ureidoglycolate hydrolase PDH PF02153.12 CDF88417.1 - 1.8e-12 46.7 0.0 2.6e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase NAD_binding_2 PF03446.10 CDF88417.1 - 1.8e-06 27.8 0.0 3.2e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 CDF88417.1 - 1.3e-05 25.5 0.0 2.5e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.14 CDF88417.1 - 0.00014 21.0 0.0 0.00027 20.1 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 CDF88417.1 - 0.001 18.7 0.0 0.0021 17.7 0.0 1.6 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.11 CDF88417.1 - 0.0049 16.3 0.0 0.01 15.3 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.13 CDF88417.1 - 0.04 13.9 0.0 0.094 12.7 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Rossmann-like PF10727.4 CDF88417.1 - 0.12 12.0 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Rossmann-like domain UDPG_MGDP_dh_N PF03721.9 CDF88417.1 - 0.15 11.4 0.0 0.28 10.5 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain EBV-NA3 PF05009.7 CDF88418.1 - 0.071 12.3 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) UPF0086 PF01868.11 CDF88419.1 - 4.5e-14 51.8 0.0 8.3e-14 50.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function UPF0086 COMPASS-Shg1 PF05205.7 CDF88420.1 - 2.7e-23 82.2 1.3 3.4e-23 81.9 0.9 1.1 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 Cullin PF00888.17 CDF88422.1 - 1.1e-13 50.6 4.4 1.1e-13 50.6 3.0 2.3 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.4 CDF88422.1 - 0.0011 18.7 0.1 0.0079 15.9 0.0 2.6 2 0 0 2 2 2 1 Cullin protein neddylation domain RhoGAP PF00620.22 CDF88423.1 - 1.4e-39 135.1 0.1 5.3e-39 133.2 0.0 2.1 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.18 CDF88423.1 - 7.5e-15 54.8 4.4 1.3e-14 54.1 0.3 2.7 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Methyltransf_PK PF05891.7 CDF88424.1 - 2.8e-93 311.2 0.0 3.2e-93 311.0 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_23 PF13489.1 CDF88424.1 - 7.6e-06 25.7 0.0 1.2e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDF88424.1 - 3.3e-05 24.4 0.0 5.3e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDF88424.1 - 0.0012 19.3 0.0 0.002 18.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDF88424.1 - 0.0033 17.8 0.0 0.006 17.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDF88424.1 - 0.0037 17.5 0.0 0.0066 16.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 CDF88424.1 - 0.032 13.4 0.0 0.061 12.4 0.0 1.4 1 1 0 1 1 1 0 O-methyltransferase P-mevalo_kinase PF04275.9 CDF88424.1 - 0.062 13.0 0.0 0.095 12.4 0.0 1.3 1 0 0 1 1 1 0 Phosphomevalonate kinase RrnaAD PF00398.15 CDF88424.1 - 0.13 11.2 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase SHMT PF00464.14 CDF88426.1 - 2e-203 675.1 0.0 2.3e-203 674.9 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.16 CDF88426.1 - 0.015 14.4 0.0 0.024 13.7 0.0 1.5 1 1 0 1 1 1 0 Beta-eliminating lyase Ras PF00071.17 CDF88427.1 - 1.6e-43 147.9 0.1 3.3e-43 146.8 0.1 1.5 1 1 0 1 1 1 1 Ras family Miro PF08477.8 CDF88427.1 - 1.1e-18 67.8 0.0 1.6e-18 67.3 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDF88427.1 - 6.5e-18 64.5 0.2 3.5e-17 62.1 0.1 1.9 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 CDF88427.1 - 2.7e-08 33.2 0.0 3.7e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 CDF88427.1 - 8.7e-08 32.1 0.1 1.4e-07 31.5 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 CDF88427.1 - 2.5e-05 23.8 0.1 0.00072 19.0 0.1 2.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.5 CDF88427.1 - 4e-05 22.8 0.0 7.9e-05 21.9 0.0 1.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit DUF258 PF03193.11 CDF88427.1 - 0.0055 15.9 0.1 0.014 14.5 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 CDF88427.1 - 0.007 15.6 0.2 1.5 8.1 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B AAA_22 PF13401.1 CDF88427.1 - 0.015 15.4 0.5 0.11 12.6 0.3 2.2 1 1 1 2 2 2 0 AAA domain Arch_ATPase PF01637.13 CDF88427.1 - 0.017 14.8 0.7 0.15 11.7 0.5 2.0 1 1 0 1 1 1 0 Archaeal ATPase DUF950 PF06106.6 CDF88427.1 - 0.11 12.5 0.1 0.31 11.1 0.0 1.8 1 1 0 1 1 1 0 Staphylococcus protein of unknown function (DUF950) G-alpha PF00503.15 CDF88427.1 - 0.16 10.6 1.1 5.6 5.5 0.0 2.5 1 1 1 2 2 2 0 G-protein alpha subunit Rif1_N PF12231.3 CDF88428.1 - 5.6e-53 180.2 12.1 1.5e-52 178.8 8.4 1.7 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal Pkinase PF00069.20 CDF88429.1 - 1.9e-59 200.9 0.0 2.4e-59 200.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF88429.1 - 7.6e-33 113.6 0.0 1e-32 113.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF88429.1 - 2.3e-08 33.3 0.0 3.7e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.6 CDF88429.1 - 0.0026 16.6 0.0 0.0044 15.8 0.0 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.9 CDF88429.1 - 0.012 14.6 0.0 0.02 13.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.15 CDF88429.1 - 0.02 14.4 0.0 0.066 12.7 0.0 1.8 2 0 0 2 2 2 0 Choline/ethanolamine kinase APH PF01636.18 CDF88429.1 - 0.14 11.8 0.0 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family UBX PF00789.15 CDF88430.1 - 3.7e-17 62.1 0.2 5.9e-16 58.2 0.0 2.4 2 0 0 2 2 2 1 UBX domain HTH_29 PF13551.1 CDF88430.1 - 0.11 12.6 1.1 0.36 10.9 0.4 1.9 2 0 0 2 2 2 0 Winged helix-turn helix DUF2004 PF09406.5 CDF88430.1 - 0.41 10.7 3.5 6.8 6.8 0.4 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2004) Snf7 PF03357.16 CDF88431.1 - 2.4e-13 49.8 14.5 4.7e-13 48.8 10.0 1.5 1 0 0 1 1 1 1 Snf7 V_ATPase_I PF01496.14 CDF88431.1 - 0.32 8.8 11.3 0.18 9.6 5.1 1.6 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family PilJ PF13675.1 CDF88431.1 - 0.68 10.2 6.4 0.91 9.8 0.7 2.5 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF2203 PF09969.4 CDF88431.1 - 1.2 9.4 6.9 0.47 10.6 0.5 2.9 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) Prefoldin_2 PF01920.15 CDF88431.1 - 1.3 8.8 13.5 1.7 8.4 5.2 3.0 2 1 0 2 2 2 0 Prefoldin subunit YlbD_coat PF14071.1 CDF88431.1 - 1.7 8.7 8.2 1.3 9.1 0.6 3.3 2 1 1 3 3 3 0 Putative coat protein Mnd1 PF03962.10 CDF88431.1 - 2.1 7.9 14.9 2.3 7.8 4.2 2.8 1 1 2 3 3 3 0 Mnd1 family DUF948 PF06103.6 CDF88431.1 - 3.8 7.4 6.7 5.8 6.8 1.6 3.2 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) COG2 PF06148.6 CDF88431.1 - 5 7.0 15.0 5.1 6.9 0.8 3.5 2 1 2 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 FliJ PF02050.11 CDF88431.1 - 6.4 6.8 11.4 0.73 9.9 1.5 2.7 2 1 1 3 3 3 0 Flagellar FliJ protein Vps26 PF03643.10 CDF88432.1 - 6.4e-112 372.8 0.2 7.3e-112 372.6 0.1 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_C PF02752.17 CDF88432.1 - 0.012 15.6 0.3 0.036 14.1 0.0 1.9 2 1 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 CDF88432.1 - 0.018 14.8 0.1 0.12 12.2 0.1 2.2 2 1 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain rRNA_proc-arch PF13234.1 CDF88434.1 - 2.4e-95 318.7 1.8 3.8e-95 318.0 1.3 1.3 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.7 CDF88434.1 - 1.6e-61 206.6 0.2 3.8e-61 205.4 0.1 1.7 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.24 CDF88434.1 - 7.1e-22 77.6 0.1 8.9e-21 74.1 0.0 2.7 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF88434.1 - 1.8e-06 27.6 0.0 5.3e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain T2SE PF00437.15 CDF88434.1 - 0.028 13.3 0.0 0.084 11.7 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein zf-C3HC4_3 PF13920.1 CDF88436.1 - 3.9e-08 32.8 12.1 7.8e-08 31.8 8.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDF88436.1 - 1.7 8.7 15.1 5.6 7.0 10.5 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) AICARFT_IMPCHas PF01808.13 CDF88437.1 - 8.6e-122 406.1 0.0 1.2e-121 405.7 0.0 1.2 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.17 CDF88437.1 - 8.1e-24 83.3 0.0 1.8e-23 82.2 0.0 1.6 1 0 0 1 1 1 1 MGS-like domain Ribosomal_L15e PF00827.12 CDF88438.1 - 2.6e-89 297.8 13.4 3e-89 297.6 9.3 1.0 1 0 0 1 1 1 1 Ribosomal L15 Pkr1 PF08636.5 CDF88441.1 - 2.4e-30 104.3 6.8 2.4e-30 104.3 4.7 1.4 2 0 0 2 2 2 1 ER protein Pkr1 Peroxin-13_N PF04088.8 CDF88441.1 - 0.00026 20.9 0.1 0.00035 20.5 0.0 1.1 1 0 0 1 1 1 1 Peroxin 13, N-terminal region DUF1772 PF08592.6 CDF88441.1 - 0.00099 18.8 0.0 0.0015 18.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) ATG22 PF11700.3 CDF88441.1 - 0.014 13.9 0.0 0.017 13.6 0.0 1.0 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like PufQ PF05398.6 CDF88441.1 - 0.018 15.0 0.0 0.046 13.7 0.0 1.6 1 1 1 2 2 2 0 PufQ cytochrome subunit WBS28 PF15164.1 CDF88441.1 - 0.039 13.0 0.7 0.056 12.5 0.4 1.3 1 1 0 1 1 1 0 Williams-Beuren syndrome chromosomal region 28 protein homologue DUF4131 PF13567.1 CDF88441.1 - 0.042 13.2 0.0 0.046 13.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) FAM176 PF14851.1 CDF88441.1 - 0.17 11.5 1.0 0.27 10.8 0.7 1.3 1 1 0 1 1 1 0 FAM176 family DUF3021 PF11457.3 CDF88441.1 - 0.56 10.0 3.9 0.68 9.8 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) Apq12 PF12716.2 CDF88441.1 - 0.98 9.1 6.5 1.4 8.6 4.5 1.2 1 0 0 1 1 1 0 Nuclear pore assembly and biogenesis MIF4G_like PF09088.6 CDF88443.1 - 1.7e-57 193.9 1.1 5.9e-57 192.1 0.7 1.9 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.6 CDF88443.1 - 5.4e-48 163.4 1.0 5.4e-48 163.4 0.7 2.3 2 1 0 2 2 2 1 MIF4G like BrkDBD PF09607.5 CDF88443.1 - 0.068 12.7 0.1 6.3 6.4 0.0 2.5 2 0 0 2 2 2 0 Brinker DNA-binding domain BLOC1_2 PF10046.4 CDF88443.1 - 0.096 12.8 1.3 0.63 10.2 0.2 2.8 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 2-ph_phosp PF04029.9 CDF88444.1 - 0.053 12.4 0.2 0.22 10.4 0.1 1.9 2 0 0 2 2 2 0 2-phosphosulpholactate phosphatase DUF4129 PF13559.1 CDF88444.1 - 0.093 12.7 0.0 0.24 11.4 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4129) DUF3827 PF12877.2 CDF88444.1 - 0.3 9.1 1.5 0.44 8.6 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) SNF2_N PF00176.18 CDF88445.1 - 1.8e-63 214.1 0.0 3.2e-63 213.2 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.6 CDF88445.1 - 1.1e-13 50.9 0.0 3.6e-13 49.3 0.0 1.9 2 0 0 2 2 2 1 HIRAN domain Helicase_C PF00271.26 CDF88445.1 - 2.7e-11 43.1 0.0 7.1e-11 41.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 CDF88445.1 - 4.5e-07 29.5 0.0 9.9e-07 28.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-RING_2 PF13639.1 CDF88445.1 - 8.7e-07 28.6 11.6 1.7e-06 27.7 8.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.1 CDF88445.1 - 2.4e-05 23.9 10.3 4.4e-05 23.0 7.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDF88445.1 - 5.1e-05 23.2 13.2 0.00011 22.1 9.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDF88445.1 - 5.9e-05 22.7 13.2 0.00012 21.7 9.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 CDF88445.1 - 0.00015 21.3 15.2 0.0003 20.3 10.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 CDF88445.1 - 0.028 14.2 4.7 0.058 13.2 3.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 CDF88445.1 - 0.64 9.6 10.3 1.4 8.5 7.1 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.1 CDF88445.1 - 0.84 9.5 11.9 2.5 8.0 8.2 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING MOZ_SAS PF01853.13 CDF88446.1 - 2e-62 209.8 0.4 2.8e-62 209.3 0.2 1.2 1 0 0 1 1 1 1 MOZ/SAS family HA2 PF04408.18 CDF88447.1 - 1.1e-21 76.7 0.2 6e-21 74.3 0.0 2.5 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 CDF88447.1 - 1.5e-16 60.2 0.1 9.1e-16 57.7 0.0 2.3 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 CDF88447.1 - 2.5e-13 49.7 0.0 1.1e-12 47.5 0.0 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 CDF88447.1 - 7.6e-06 25.5 0.0 2.1e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 CDF88447.1 - 0.00024 21.2 0.1 0.0011 19.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 CDF88447.1 - 0.0064 15.4 0.0 0.014 14.3 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein KaiC PF06745.8 CDF88447.1 - 0.017 14.2 0.0 0.05 12.7 0.0 1.9 1 0 0 1 1 1 0 KaiC Bromodomain PF00439.20 CDF88448.1 - 2.3e-07 30.6 0.1 7.8e-07 28.9 0.1 1.9 1 0 0 1 1 1 1 Bromodomain Nramp PF01566.13 CDF88449.1 - 6e-94 314.7 16.5 6e-94 314.7 11.5 1.3 2 0 0 2 2 2 1 Natural resistance-associated macrophage protein HAD_2 PF13419.1 CDF88451.1 - 2.4e-14 53.9 0.0 3.6e-14 53.3 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 CDF88451.1 - 4.9e-06 26.1 0.0 1.1e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like PqqD PF05402.7 CDF88451.1 - 0.063 13.2 0.2 0.21 11.6 0.0 1.9 2 0 0 2 2 2 0 Coenzyme PQQ synthesis protein D (PqqD) COX6B PF02297.12 CDF88452.1 - 1.1e-20 73.4 4.4 1.3e-20 73.2 3.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb APOBEC_C PF05240.9 CDF88452.1 - 0.15 11.4 2.6 0.44 9.9 1.8 1.8 1 1 0 1 1 1 0 APOBEC-like C-terminal domain UPF0203 PF05254.7 CDF88452.1 - 0.6 9.9 5.6 0.94 9.3 1.2 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) RIC1 PF07064.8 CDF88453.1 - 3.9e-19 69.1 1.1 8.2e-19 68.0 0.8 1.4 1 0 0 1 1 1 1 RIC1 Peptidase_M90 PF06167.7 CDF88453.1 - 0.13 11.6 0.4 5.7 6.2 0.0 2.6 2 1 0 2 2 2 0 Glucose-regulated metallo-peptidase M90 WD40 PF00400.27 CDF88454.1 - 5.9e-20 70.3 10.5 1.8e-07 30.7 0.0 5.4 6 0 0 6 6 6 3 WD domain, G-beta repeat CAF1C_H4-bd PF12265.3 CDF88454.1 - 2e-19 69.2 0.0 6.4e-19 67.6 0.0 2.0 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex eIF2A PF08662.6 CDF88454.1 - 0.0034 17.0 1.0 0.018 14.7 0.1 2.6 3 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A TEX19 PF15553.1 CDF88454.1 - 0.65 9.8 8.5 0.47 10.2 0.7 3.1 3 0 0 3 3 3 0 Testis-expressed protein 19 DUF814 PF05670.8 CDF88455.1 - 2.4e-17 62.6 0.0 3.8e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF814) CH PF00307.26 CDF88455.1 - 0.012 15.6 1.0 4.2 7.4 0.0 2.8 1 1 1 2 2 2 0 Calponin homology (CH) domain Meiotic_rec114 PF03525.9 CDF88456.1 - 1.7e-15 56.3 0.0 1.7e-15 56.3 0.0 2.4 2 1 0 2 2 2 1 Meiotic recombination protein rec114 Herpes_U59 PF04529.7 CDF88456.1 - 0.024 13.5 0.0 0.039 12.8 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus U59 protein Macoilin PF09726.4 CDF88457.1 - 1.4 7.1 15.2 1.6 6.8 10.5 1.0 1 0 0 1 1 1 0 Transmembrane protein Apc1 PF12859.2 CDF88457.1 - 1.9 8.7 10.2 16 5.8 7.1 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 1 T4_baseplate PF12322.3 CDF88458.1 - 0.061 12.5 0.3 0.097 11.9 0.2 1.2 1 0 0 1 1 1 0 T4 bacteriophage base plate protein CLTH PF10607.4 CDF88459.1 - 2.9e-20 72.4 0.0 4.4e-20 71.8 0.0 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain GATA PF00320.22 CDF88460.1 - 7.7e-15 53.9 2.1 1.5e-14 53.0 1.4 1.5 1 0 0 1 1 1 1 GATA zinc finger CDK2AP PF09806.4 CDF88460.1 - 1.3 9.1 8.9 8.2 6.6 0.0 2.3 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein PAT1 PF09770.4 CDF88460.1 - 1.7 6.7 20.0 2.1 6.4 13.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 BAF1_ABF1 PF04684.8 CDF88460.1 - 3.1 6.5 12.9 4.6 5.9 8.9 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor MFS_1 PF07690.11 CDF88461.1 - 2.1e-37 128.6 43.8 2.4e-30 105.4 19.3 3.0 2 1 1 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.8 CDF88461.1 - 2.2e-12 45.9 10.9 2.2e-12 45.9 7.5 2.9 1 1 1 3 3 3 1 Fungal trichothecene efflux pump (TRI12) DRMBL PF07522.9 CDF88462.1 - 1.5e-22 79.7 0.1 2.6e-22 78.9 0.0 1.4 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.2 CDF88462.1 - 4.2e-07 29.7 0.5 9.5e-07 28.5 0.2 1.7 1 1 1 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 CDF88462.1 - 0.075 12.6 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Fiji_64_capsid PF05880.6 CDF88462.1 - 0.12 10.7 0.1 0.2 9.9 0.1 1.3 1 0 0 1 1 1 0 Fijivirus 64 kDa capsid protein Arf PF00025.16 CDF88463.1 - 1.5e-39 135.0 0.0 1.8e-39 134.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 CDF88463.1 - 1.6e-11 43.8 0.0 2.1e-11 43.4 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 CDF88463.1 - 4.1e-11 42.1 0.5 1.1e-05 24.2 0.1 2.9 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.18 CDF88463.1 - 2.9e-08 33.6 0.0 4.7e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 CDF88463.1 - 1.5e-07 30.7 0.0 2e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 CDF88463.1 - 6.4e-07 28.9 0.0 1.3e-05 24.7 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Miro PF08477.8 CDF88463.1 - 1.8e-05 25.2 0.0 2.5e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein FeoB_N PF02421.13 CDF88463.1 - 2.2e-05 23.7 0.0 0.00016 21.0 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B cobW PF02492.14 CDF88463.1 - 0.00077 18.9 0.0 0.038 13.4 0.0 2.1 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain SRPRB PF09439.5 CDF88463.1 - 0.013 14.7 0.0 0.024 13.8 0.0 1.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF258 PF03193.11 CDF88463.1 - 0.083 12.0 0.0 0.27 10.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Ldh_1_N PF00056.18 CDF88464.1 - 2.9e-45 153.5 0.4 4.7e-45 152.8 0.3 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 CDF88464.1 - 1.8e-39 135.2 0.0 2.6e-39 134.7 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.14 CDF88464.1 - 0.00015 20.5 0.0 0.00022 20.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.14 CDF88464.1 - 0.0028 16.7 0.1 0.012 14.7 0.1 2.0 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Semialdhyde_dh PF01118.19 CDF88464.1 - 0.0088 16.3 0.2 0.022 15.0 0.0 1.8 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.15 CDF88464.1 - 0.033 14.0 0.4 0.21 11.5 0.0 2.4 3 0 0 3 3 3 0 Dihydrodipicolinate reductase, N-terminus DUF1932 PF09130.6 CDF88464.1 - 0.11 12.2 0.0 0.32 10.7 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1932) Glyco_hydro_4 PF02056.11 CDF88464.1 - 0.11 11.7 0.1 3.2 7.0 0.0 2.3 1 1 0 1 1 1 0 Family 4 glycosyl hydrolase Pkinase PF00069.20 CDF88465.1 - 8.3e-58 195.5 0.0 9.9e-58 195.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF88465.1 - 2.5e-24 85.7 0.0 3.5e-24 85.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CDF88465.1 - 0.012 15.3 0.1 0.025 14.2 0.1 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.15 CDF88465.1 - 0.098 12.2 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase TPP_enzyme_N PF02776.13 CDF88466.1 - 6e-31 107.2 0.0 9.8e-31 106.5 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.17 CDF88466.1 - 3.4e-24 85.1 0.0 5.2e-23 81.3 0.0 2.3 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.16 CDF88466.1 - 8.7e-15 54.6 0.0 1.9e-14 53.4 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Abhydrolase_1 PF00561.15 CDF88466.1 - 0.061 12.8 0.1 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2064 PF09837.4 CDF88466.1 - 0.14 11.7 0.0 0.29 10.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2064) Aminotran_3 PF00202.16 CDF88467.1 - 2.8e-57 194.1 0.0 3.4e-57 193.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.16 CDF88467.1 - 0.00012 21.3 0.0 0.00024 20.3 0.0 1.5 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 CDF88467.1 - 0.011 14.7 0.0 0.14 11.0 0.0 2.4 1 1 1 2 2 2 0 Aminotransferase class I and II Ribosomal_60s PF00428.14 CDF88469.1 - 1.4e-21 76.6 3.6 1.7e-21 76.3 2.5 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Ribosomal_L13e PF01294.13 CDF88470.1 - 2.1e-68 229.3 3.6 2.8e-68 228.9 2.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e Ribosomal_S9 PF00380.14 CDF88471.1 - 6.5e-39 132.9 0.3 7.4e-39 132.7 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Jnk-SapK_ap_N PF09744.4 CDF88472.1 - 0.00048 20.1 11.2 0.00048 20.1 7.8 1.8 2 0 0 2 2 2 1 JNK_SAPK-associated protein-1 DEAD PF00270.24 CDF88473.1 - 4.8e-35 120.5 0.4 9.6e-35 119.5 0.1 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF88473.1 - 8.7e-23 79.9 0.0 6.7e-22 77.1 0.1 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDF88473.1 - 9.3e-06 25.5 0.1 2.8e-05 24.0 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HTH_psq PF05225.11 CDF88474.1 - 0.0013 18.2 0.1 0.011 15.2 0.1 2.3 1 1 0 1 1 1 1 helix-turn-helix, Psq domain SR-25 PF10500.4 CDF88474.1 - 0.021 14.3 1.7 0.059 12.8 1.2 1.7 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Phage_portal PF04860.7 CDF88474.1 - 0.061 11.9 0.1 0.11 11.1 0.0 1.3 1 0 0 1 1 1 0 Phage portal protein Pyr_redox_2 PF07992.9 CDF88475.1 - 1.4e-22 80.5 0.0 4.3e-14 52.8 0.0 3.7 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CDF88475.1 - 2.7e-13 50.0 0.0 3.5e-12 46.5 0.0 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CDF88475.1 - 1.2e-06 28.8 0.0 0.012 15.6 0.0 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Ig_2 PF13895.1 CDF88475.1 - 0.11 12.6 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain 4F5 PF04419.9 CDF88476.1 - 5.6e-10 39.7 11.3 5.6e-10 39.7 7.9 2.5 2 1 0 2 2 2 1 4F5 protein family Dishevelled PF02377.10 CDF88476.1 - 0.42 10.8 2.5 0.32 11.2 0.9 1.4 1 1 1 2 2 2 0 Dishevelled specific domain WD40 PF00400.27 CDF88477.1 - 3.8e-30 102.6 3.7 1.4e-09 37.4 0.1 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat eIF2A PF08662.6 CDF88477.1 - 7.4e-05 22.5 0.0 1.2 8.7 0.0 3.1 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.11 CDF88477.1 - 0.062 11.5 0.0 0.2 9.9 0.0 1.8 2 1 0 2 2 2 0 Cytochrome D1 heme domain DLH PF01738.13 CDF88478.1 - 1.1e-23 83.6 0.0 1.3e-23 83.4 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 CDF88478.1 - 5.1e-07 29.5 0.0 6.5e-07 29.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CDF88478.1 - 1.5e-05 24.2 0.1 5.6e-05 22.4 0.0 2.1 2 1 0 2 2 2 1 Prolyl oligopeptidase family DUF2305 PF10230.4 CDF88478.1 - 0.0095 15.3 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Chlorophyllase PF07224.6 CDF88478.1 - 0.042 12.6 0.0 0.059 12.1 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Chlorophyllase2 PF12740.2 CDF88478.1 - 0.044 12.6 0.0 0.056 12.3 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Prefoldin_3 PF13758.1 CDF88480.1 - 0.0075 16.0 0.1 0.015 15.0 0.0 1.6 1 1 0 1 1 1 1 Prefoldin subunit CytochromB561_N PF09786.4 CDF88480.1 - 0.039 12.4 3.6 0.04 12.3 2.5 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal L27_2 PF09045.5 CDF88480.1 - 0.1 12.1 0.0 12 5.4 0.0 2.5 2 0 0 2 2 2 0 L27_2 DUF2207 PF09972.4 CDF88481.1 - 0.13 10.8 0.6 0.14 10.7 0.4 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Ribophorin_II PF05817.9 CDF88482.1 - 1.6e-05 23.3 2.2 2e-05 23.0 1.6 1.1 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II Peptidase_S24 PF00717.18 CDF88483.1 - 2.9e-06 26.8 0.0 1.1e-05 24.9 0.0 2.0 2 0 0 2 2 2 1 Peptidase S24-like Peptidase_S26 PF10502.4 CDF88483.1 - 0.00096 18.6 0.0 0.0014 18.1 0.0 1.3 1 0 0 1 1 1 1 Signal peptidase, peptidase S26 adh_short PF00106.20 CDF88484.1 - 3.6e-06 26.9 0.0 3.8e-05 23.6 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase Semialdhyde_dh PF01118.19 CDF88484.1 - 0.034 14.4 0.0 0.057 13.7 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain LUC7 PF03194.10 CDF88485.1 - 1.1e-70 238.1 9.7 1.2e-70 237.9 6.7 1.0 1 0 0 1 1 1 1 LUC7 N_terminus WD-3 PF09765.4 CDF88485.1 - 0.18 11.0 2.2 1.7 7.8 0.1 2.0 1 1 1 2 2 2 0 WD-repeat region Seryl_tRNA_N PF02403.17 CDF88485.1 - 0.2 11.6 6.4 6 6.9 0.1 2.4 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Med4 PF10018.4 CDF88485.1 - 0.36 10.2 3.0 1.2 8.5 2.1 1.8 1 1 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 HR1 PF02185.11 CDF88485.1 - 0.73 9.6 5.9 0.47 10.2 0.3 2.9 2 1 1 3 3 3 0 Hr1 repeat ADH_zinc_N_2 PF13602.1 CDF88486.1 - 5.3e-13 49.9 0.0 9e-13 49.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CDF88486.1 - 2.9e-05 23.7 0.0 6.8e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CDF88486.1 - 4.5e-05 23.0 0.0 7.9e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF2418 PF10332.4 CDF88487.1 - 2.1e-20 72.8 1.8 3.9e-20 71.9 1.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2418) Calpain_III PF01067.17 CDF88488.1 - 0.0072 15.9 0.4 0.22 11.1 0.1 3.1 3 1 0 3 3 3 1 Calpain large subunit, domain III Prenyltrans PF00432.16 CDF88489.1 - 2e-38 129.5 10.0 1.5e-10 40.4 0.1 5.7 6 1 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 CDF88489.1 - 7.6e-22 77.8 0.0 3.4e-15 56.4 0.0 3.0 1 1 2 3 3 3 2 Prenyltransferase-like Crl PF07417.7 CDF88489.1 - 0.00052 19.7 0.0 0.0013 18.4 0.0 1.6 1 0 0 1 1 1 1 Transcriptional regulator Crl Prenyltrans_1 PF13243.1 CDF88489.1 - 0.0022 17.9 0.0 0.022 14.7 0.0 2.2 1 1 1 2 2 2 2 Prenyltransferase-like A2M_comp PF07678.9 CDF88489.1 - 0.14 11.3 0.0 8.7 5.4 0.0 2.2 2 0 0 2 2 2 0 A-macroglobulin complement component UBX PF00789.15 CDF88490.1 - 1.1e-11 44.5 0.0 2.1e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 UBX domain Nop25 PF09805.4 CDF88490.1 - 0.11 12.5 7.6 5 7.1 4.6 2.3 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) PVL_ORF50 PF07768.6 CDF88490.1 - 0.12 12.3 4.6 0.23 11.4 3.2 1.3 1 0 0 1 1 1 0 PVL ORF-50-like family SRP14 PF02290.10 CDF88491.1 - 1e-23 83.0 0.3 1.6e-23 82.4 0.2 1.3 1 0 0 1 1 1 1 Signal recognition particle 14kD protein Methyltransf_31 PF13847.1 CDF88492.1 - 8e-13 48.2 0.0 1.3e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDF88492.1 - 8.7e-11 42.3 0.0 1.3e-10 41.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDF88492.1 - 1.4e-10 41.4 0.0 2.4e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDF88492.1 - 5.4e-10 39.5 0.1 9.8e-10 38.7 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDF88492.1 - 7.2e-09 36.0 0.0 1.3e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CDF88492.1 - 1.7e-07 30.6 0.0 2.3e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.1 CDF88492.1 - 6.4e-07 29.2 0.0 7.6e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 CDF88492.1 - 5.1e-05 22.9 0.0 8.1e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CDF88492.1 - 0.00062 18.8 0.0 0.0012 17.9 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.9 CDF88492.1 - 0.00073 18.9 0.1 0.0022 17.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain tRNA_U5-meth_tr PF05958.6 CDF88492.1 - 0.0041 15.8 0.0 0.0063 15.2 0.0 1.2 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase PrmA PF06325.8 CDF88492.1 - 0.0096 15.0 0.0 0.016 14.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 CDF88492.1 - 0.016 15.2 0.0 0.03 14.3 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain PCMT PF01135.14 CDF88492.1 - 0.083 12.4 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Glutaredoxin PF00462.19 CDF88493.1 - 2.9e-19 68.8 0.6 6e-17 61.3 0.0 2.6 3 0 0 3 3 3 1 Glutaredoxin Thioredoxin PF00085.15 CDF88493.1 - 1.7e-15 56.5 0.0 3.4e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 CDF88493.1 - 8.6e-07 28.9 0.0 0.00071 19.6 0.0 2.6 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.1 CDF88493.1 - 5.7e-05 23.2 0.1 0.0005 20.2 0.0 2.4 1 1 1 2 2 2 1 Thioredoxin-like domain AhpC-TSA PF00578.16 CDF88493.1 - 0.00019 21.0 0.0 0.00037 20.1 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.1 CDF88493.1 - 0.001 19.0 0.0 0.0056 16.6 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin-like Redoxin PF08534.5 CDF88493.1 - 0.0093 15.5 0.1 0.023 14.2 0.0 1.6 1 1 0 1 1 1 1 Redoxin ArsC PF03960.10 CDF88493.1 - 0.022 14.8 0.0 0.1 12.6 0.0 2.1 2 1 1 3 3 3 0 ArsC family DIM1 PF02966.11 CDF88493.1 - 0.03 13.8 0.0 0.05 13.1 0.0 1.4 1 0 0 1 1 1 0 Mitosis protein DIM1 FAM176 PF14851.1 CDF88493.1 - 0.046 13.4 0.2 0.066 12.8 0.1 1.3 1 0 0 1 1 1 0 FAM176 family Tol_Tol_Ttg2 PF05494.7 CDF88493.1 - 0.11 12.0 0.2 0.18 11.3 0.2 1.3 1 0 0 1 1 1 0 Toluene tolerance, Ttg2 Myc_N PF01056.13 CDF88493.1 - 0.22 10.6 2.4 0.28 10.3 1.6 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Rad17 PF03215.10 CDF88494.1 - 1.9e-91 307.3 0.1 3.6e-67 227.2 0.0 2.4 2 1 1 3 3 3 2 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 CDF88494.1 - 1.3e-05 25.2 0.1 4.5e-05 23.5 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.24 CDF88494.1 - 0.0014 18.8 0.0 0.0028 17.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.1 CDF88494.1 - 0.0015 18.0 0.0 0.0034 16.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_17 PF13207.1 CDF88494.1 - 0.0031 18.3 0.0 0.016 15.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 CDF88494.1 - 0.0047 17.0 0.0 0.024 14.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 CDF88494.1 - 0.01 15.7 0.0 0.024 14.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.1 CDF88494.1 - 0.021 14.7 0.0 0.055 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 CDF88494.1 - 0.025 14.7 0.1 0.33 11.1 0.0 2.4 2 0 0 2 2 2 0 RNA helicase DUF258 PF03193.11 CDF88494.1 - 0.045 12.9 0.0 0.095 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_25 PF13481.1 CDF88494.1 - 0.052 12.9 0.0 0.14 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 CDF88494.1 - 0.069 13.4 0.0 0.42 10.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain ArgK PF03308.11 CDF88494.1 - 0.09 11.5 0.0 0.16 10.7 0.0 1.3 1 0 0 1 1 1 0 ArgK protein Sec63 PF02889.11 CDF88495.1 - 7e-156 518.2 4.9 1.6e-80 270.6 0.4 2.4 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 CDF88495.1 - 2.8e-47 160.3 0.1 5.3e-30 104.1 0.1 2.8 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.10 CDF88495.1 - 3.3e-14 53.1 0.1 2e-08 34.2 0.0 3.0 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.26 CDF88495.1 - 9e-10 38.2 0.0 3e-08 33.4 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 CDF88495.1 - 9e-06 24.6 0.0 3.4e-05 22.8 0.0 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain AAA_22 PF13401.1 CDF88495.1 - 2e-05 24.7 2.2 0.018 15.1 0.0 4.6 4 0 0 4 4 4 1 AAA domain IstB_IS21 PF01695.12 CDF88495.1 - 0.0039 16.6 0.2 0.8 9.0 0.0 3.8 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA PF00004.24 CDF88495.1 - 0.0068 16.6 0.1 1.2 9.2 0.0 3.5 3 2 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 CDF88495.1 - 0.007 16.0 0.0 3.7 7.3 0.0 2.7 2 0 0 2 2 2 1 Part of AAA domain Zeta_toxin PF06414.7 CDF88495.1 - 0.022 13.8 0.0 4.3 6.3 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin PhoH PF02562.11 CDF88495.1 - 0.023 13.9 0.0 5.6 6.1 0.0 2.6 2 0 0 2 2 2 0 PhoH-like protein AAA_10 PF12846.2 CDF88495.1 - 0.065 12.6 1.4 0.63 9.4 0.0 3.0 4 0 0 4 4 4 0 AAA-like domain DUF1227 PF06777.6 CDF88496.1 - 3.8e-57 192.1 0.6 8.7e-57 190.9 0.4 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1227) DEAD_2 PF06733.10 CDF88496.1 - 3.2e-52 176.4 2.8 6.4e-52 175.4 1.9 1.5 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.1 CDF88496.1 - 1.2e-45 155.4 0.0 4.5e-45 153.6 0.0 2.0 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD PF00270.24 CDF88496.1 - 0.0017 17.8 0.0 0.42 10.0 0.0 2.6 2 0 0 2 2 2 2 DEAD/DEAH box helicase SNF2_N PF00176.18 CDF88496.1 - 0.018 13.8 0.2 0.93 8.2 0.0 2.3 2 0 0 2 2 2 0 SNF2 family N-terminal domain ResIII PF04851.10 CDF88496.1 - 0.035 13.9 0.0 2.1 8.1 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit ADK PF00406.17 CDF88497.1 - 9.8e-44 148.8 0.0 1.2e-43 148.6 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.9 CDF88497.1 - 1.7e-13 49.9 0.0 3e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.1 CDF88497.1 - 1.1e-05 25.2 0.0 3.5e-05 23.7 0.0 1.8 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.1 CDF88497.1 - 6.7e-05 23.1 0.0 0.00054 20.2 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.1 CDF88497.1 - 0.00027 21.7 0.0 0.00052 20.8 0.0 1.3 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 CDF88497.1 - 0.022 13.8 0.1 0.046 12.8 0.0 1.5 2 0 0 2 2 2 0 Zeta toxin Mg_chelatase PF01078.16 CDF88497.1 - 0.16 11.1 0.1 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI MutS_V PF00488.16 CDF88498.1 - 1.3e-77 260.4 0.1 1.9e-77 259.8 0.1 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 CDF88498.1 - 1.6e-38 132.5 0.0 3.1e-38 131.6 0.0 1.5 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.15 CDF88498.1 - 1.5e-32 111.9 0.0 1.1e-31 109.1 0.0 2.3 2 0 0 2 2 2 1 MutS domain I MutS_IV PF05190.13 CDF88498.1 - 9.5e-17 60.9 0.0 2.4e-16 59.6 0.0 1.8 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.12 CDF88498.1 - 8.2e-14 51.8 0.0 2.7e-13 50.1 0.0 1.9 1 0 0 1 1 1 1 MutS domain II AAA_29 PF13555.1 CDF88498.1 - 0.02 14.4 0.0 0.063 12.8 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain JmjC PF02373.17 CDF88499.1 - 2.1e-40 137.5 1.4 3.1e-40 136.9 0.4 1.8 2 0 0 2 2 1 1 JmjC domain, hydroxylase JmjN PF02375.12 CDF88499.1 - 1.1e-14 53.6 1.3 2.8e-14 52.3 0.9 1.8 1 0 0 1 1 1 1 jmjN domain zf-C2H2 PF00096.21 CDF88499.1 - 8.7e-08 32.0 15.7 0.00026 21.1 1.8 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CDF88499.1 - 1.4e-07 31.4 5.9 1.4e-07 31.4 4.1 3.1 3 0 0 3 3 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 CDF88499.1 - 5.6e-07 29.4 11.5 0.00052 20.1 0.5 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.1 CDF88499.1 - 0.0068 16.2 9.3 0.012 15.5 2.5 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger HypA PF01155.14 CDF88499.1 - 0.019 14.6 0.4 0.039 13.6 0.2 1.4 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zf-C2H2_jaz PF12171.3 CDF88499.1 - 0.025 14.7 8.7 0.062 13.4 1.9 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.5 CDF88499.1 - 0.71 9.8 6.8 3.9 7.4 0.5 2.5 1 1 1 2 2 2 0 Zinc ribbon domain zf-Di19 PF05605.7 CDF88499.1 - 0.74 9.9 3.9 1.5 9.0 2.7 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.2 CDF88499.1 - 2 8.7 8.4 7.7 6.8 0.3 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type C1_4 PF07975.7 CDF88499.1 - 2.1 8.4 4.5 12 6.0 0.4 2.4 1 1 1 2 2 2 0 TFIIH C1-like domain DUF1610 PF07754.6 CDF88499.1 - 3.6 7.7 8.5 1.6 8.9 1.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) zf-UBP PF02148.14 CDF88499.1 - 3.7 7.7 6.5 70 3.6 3.7 3.0 2 1 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein PolyA_pol PF01743.15 CDF88500.1 - 3.1e-31 108.1 0.1 6.6e-31 107.1 0.1 1.6 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.2 CDF88500.1 - 0.00012 21.5 0.0 0.00028 20.4 0.0 1.6 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.1 CDF88500.1 - 0.00069 19.4 0.0 0.0016 18.2 0.0 1.6 1 0 0 1 1 1 1 tRNA nucleotidyltransferase domain 2 putative E1-E2_ATPase PF00122.15 CDF88502.1 - 1.2e-14 53.9 0.0 1.2e-14 53.9 0.0 2.5 3 0 0 3 3 3 1 E1-E2 ATPase HAD PF12710.2 CDF88502.1 - 3.1e-12 47.0 0.1 1.1e-11 45.2 0.0 2.1 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CDF88502.1 - 1e-11 44.5 0.0 2.7e-11 43.2 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase PF00702.21 CDF88502.1 - 1.8e-10 41.6 0.0 8e-09 36.2 0.0 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CDF88502.1 - 0.0059 16.2 0.1 0.0059 16.2 0.1 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Med15 PF09606.5 CDF88502.1 - 1.4 6.9 31.1 2.1 6.4 21.5 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4613 PF15390.1 CDF88502.1 - 2.4 6.2 8.6 3.7 5.6 5.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4613) LCD1 PF09798.4 CDF88502.1 - 3.6 5.4 13.5 5.7 4.8 9.3 1.2 1 0 0 1 1 1 0 DNA damage checkpoint protein DUF4175 PF13779.1 CDF88502.1 - 6.9 4.2 31.8 11 3.6 22.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) UQ_con PF00179.21 CDF88503.1 - 6.5e-47 158.4 0.0 7.3e-47 158.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CDF88503.1 - 0.0016 18.1 0.0 0.0022 17.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.8 CDF88503.1 - 0.022 14.4 0.0 0.041 13.5 0.0 1.5 1 1 0 1 1 1 0 UEV domain RWD PF05773.17 CDF88503.1 - 0.022 14.6 0.0 0.029 14.2 0.0 1.3 1 0 0 1 1 1 0 RWD domain RRM_1 PF00076.17 CDF88504.1 - 1.1e-86 284.4 5.1 2.4e-22 78.3 0.2 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF88504.1 - 2.6e-60 200.2 0.4 1.5e-15 56.8 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF88504.1 - 2e-43 146.0 0.1 1.5e-10 40.7 0.0 4.7 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.13 CDF88504.1 - 6.5e-23 80.1 1.2 7e-22 76.8 0.0 2.8 3 0 0 3 3 3 1 Poly-adenylate binding protein, unique domain RRM_3 PF08777.6 CDF88504.1 - 5.2e-09 35.8 8.6 0.0027 17.5 1.5 4.7 4 1 1 5 5 4 3 RNA binding motif Nup35_RRM_2 PF14605.1 CDF88504.1 - 5.4e-05 22.8 0.1 0.24 11.2 0.0 3.2 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif CbiG_mid PF11761.3 CDF88504.1 - 0.0055 16.9 0.1 0.56 10.4 0.0 2.6 2 0 0 2 2 2 1 Cobalamin biosynthesis central region TC1 PF15063.1 CDF88504.1 - 0.0088 15.5 0.4 0.099 12.2 0.0 2.7 3 0 0 3 3 3 1 Thyroid cancer protein 1 OB_RNB PF08206.6 CDF88504.1 - 0.026 14.0 5.5 14 5.3 0.6 3.8 3 1 0 3 3 3 0 Ribonuclease B OB domain Thioredoxin_8 PF13905.1 CDF88504.1 - 0.088 12.9 1.8 0.39 10.8 0.1 2.9 3 1 0 3 3 3 0 Thioredoxin-like PNPase PF03726.9 CDF88504.1 - 4.2 7.7 6.4 0.97 9.7 0.0 3.0 3 0 0 3 3 3 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain SNF2_N PF00176.18 CDF88505.1 - 4.9e-76 255.3 0.1 1.1e-75 254.2 0.1 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF4208 PF13907.1 CDF88505.1 - 1.3e-28 99.2 0.1 1.3e-28 99.2 0.1 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4208) Chromo PF00385.19 CDF88505.1 - 9.4e-23 79.6 2.8 2.6e-13 49.4 0.3 3.1 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.26 CDF88505.1 - 1.1e-15 57.2 0.1 6.2e-15 54.8 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 CDF88505.1 - 0.00044 19.7 0.0 0.00096 18.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ABC_tran PF00005.22 CDF88506.1 - 3e-37 127.9 0.0 2.6e-18 66.6 0.0 2.4 2 0 0 2 2 2 2 ABC transporter RLI PF04068.10 CDF88506.1 - 3.2e-15 55.3 5.7 7.5e-15 54.2 3.9 1.7 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_21 PF13304.1 CDF88506.1 - 1.8e-13 51.0 9.3 0.0047 16.9 0.0 4.3 2 2 2 4 4 4 4 AAA domain SMC_N PF02463.14 CDF88506.1 - 9.3e-10 38.1 4.3 0.0061 15.8 0.6 3.9 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 CDF88506.1 - 4.3e-09 35.9 3.5 0.079 11.9 0.0 4.4 3 2 2 5 5 5 3 AAA ATPase domain Fer4 PF00037.22 CDF88506.1 - 4.2e-07 29.3 4.0 4.2e-07 29.3 2.8 2.8 3 0 0 3 3 3 1 4Fe-4S binding domain AAA PF00004.24 CDF88506.1 - 2.4e-06 27.7 0.0 0.017 15.3 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) DUF258 PF03193.11 CDF88506.1 - 8.2e-06 25.0 1.3 0.035 13.2 0.0 2.8 3 0 0 3 3 2 2 Protein of unknown function, DUF258 Fer4_6 PF12837.2 CDF88506.1 - 8.9e-06 25.3 12.2 5.6e-05 22.8 1.8 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_29 PF13555.1 CDF88506.1 - 3e-05 23.4 0.5 0.14 11.6 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.1 CDF88506.1 - 4.5e-05 23.5 0.0 0.034 14.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CDF88506.1 - 4.7e-05 23.4 0.0 0.0087 16.0 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 CDF88506.1 - 0.00012 22.8 0.1 0.51 11.1 0.0 2.9 2 1 0 2 2 2 2 AAA domain Fer4_21 PF14697.1 CDF88506.1 - 0.00058 19.6 11.1 0.0012 18.6 7.7 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Miro PF08477.8 CDF88506.1 - 0.00062 20.2 0.5 1.6 9.2 0.0 3.1 2 1 0 2 2 2 1 Miro-like protein Fer4_7 PF12838.2 CDF88506.1 - 0.00099 19.4 1.7 0.00099 19.4 1.1 2.5 1 1 2 3 3 3 2 4Fe-4S dicluster domain Fer4_2 PF12797.2 CDF88506.1 - 0.0015 18.3 12.6 0.0033 17.2 1.5 2.6 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_18 PF13238.1 CDF88506.1 - 0.0016 18.7 0.1 2.4 8.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.17 CDF88506.1 - 0.0019 17.1 0.0 0.48 9.2 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA_25 PF13481.1 CDF88506.1 - 0.0019 17.6 0.1 1.2 8.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 CDF88506.1 - 0.0019 17.8 1.4 0.23 11.0 0.0 2.5 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.17 CDF88506.1 - 0.002 18.2 0.0 0.71 10.0 0.0 2.9 3 0 0 3 3 2 1 RNA helicase Fer4_9 PF13187.1 CDF88506.1 - 0.0024 18.0 2.0 0.0024 18.0 1.4 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain AAA_28 PF13521.1 CDF88506.1 - 0.0036 17.2 0.0 1.1 9.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 CDF88506.1 - 0.0045 16.6 1.1 0.71 9.5 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Fer4_16 PF13484.1 CDF88506.1 - 0.005 17.5 0.1 0.005 17.5 0.1 2.5 2 0 0 2 2 2 1 4Fe-4S double cluster binding domain VirE PF05272.6 CDF88506.1 - 0.0054 16.2 0.0 0.94 8.9 0.0 2.4 2 0 0 2 2 2 1 Virulence-associated protein E Rad17 PF03215.10 CDF88506.1 - 0.006 15.3 0.0 1.1 7.8 0.0 2.2 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein Fer4_3 PF12798.2 CDF88506.1 - 0.0062 17.0 5.0 0.0062 17.0 3.4 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_10 PF13237.1 CDF88506.1 - 0.0075 16.0 1.4 0.0075 16.0 1.0 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain AAA_33 PF13671.1 CDF88506.1 - 0.0085 15.9 0.0 1.2 9.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.1 CDF88506.1 - 0.009 15.6 0.6 0.17 11.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.17 CDF88506.1 - 0.01 15.2 3.6 0.27 10.6 0.1 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_5 PF07728.9 CDF88506.1 - 0.014 15.0 1.5 0.1 12.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 CDF88506.1 - 0.02 14.7 0.7 8.1 6.3 0.0 3.2 3 1 0 3 3 2 0 AAA domain UPF0079 PF02367.12 CDF88506.1 - 0.021 14.4 0.4 0.24 11.0 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 T2SE PF00437.15 CDF88506.1 - 0.025 13.5 0.0 0.085 11.7 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein Fer4_17 PF13534.1 CDF88506.1 - 0.034 14.4 0.2 0.034 14.4 0.1 2.7 2 0 0 2 2 2 0 4Fe-4S dicluster domain SbcCD_C PF13558.1 CDF88506.1 - 0.035 14.0 0.1 21 5.1 0.0 3.4 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit MMR_HSR1 PF01926.18 CDF88506.1 - 0.062 13.2 0.0 7.2 6.5 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase Fer4_8 PF13183.1 CDF88506.1 - 0.066 13.2 8.0 0.081 12.9 0.8 1.8 1 1 1 2 2 2 0 4Fe-4S dicluster domain AAA_24 PF13479.1 CDF88506.1 - 0.068 12.7 1.9 0.89 9.0 0.0 2.8 3 0 0 3 3 3 0 AAA domain ArgK PF03308.11 CDF88506.1 - 0.071 11.8 0.3 3.2 6.4 0.0 2.2 2 0 0 2 2 2 0 ArgK protein AAA_23 PF13476.1 CDF88506.1 - 0.1 12.9 6.1 0.13 12.5 0.0 2.7 2 1 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 CDF88506.1 - 0.18 11.2 1.2 0.54 9.7 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Mg_chelatase PF01078.16 CDF88506.1 - 0.22 10.6 0.7 0.48 9.5 0.0 1.9 2 0 0 2 2 1 0 Magnesium chelatase, subunit ChlI Fer4_4 PF12800.2 CDF88506.1 - 0.3 11.5 14.2 0.091 13.1 1.7 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Thymidylate_kin PF02223.12 CDF88506.1 - 0.3 10.4 1.2 12 5.2 0.0 3.0 4 0 0 4 4 3 0 Thymidylate kinase AAA_13 PF13166.1 CDF88506.1 - 0.35 9.2 0.0 0.35 9.2 0.0 2.2 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.1 CDF88506.1 - 0.41 10.4 1.9 0.7 9.6 0.0 2.2 2 0 0 2 2 1 0 Part of AAA domain Fer4_18 PF13746.1 CDF88506.1 - 5.7 7.4 10.4 0.3 11.5 2.9 2.0 1 1 0 2 2 1 0 4Fe-4S dicluster domain ChaC PF04752.7 CDF88507.1 - 5.1e-54 182.9 0.0 6.9e-54 182.4 0.0 1.2 1 0 0 1 1 1 1 ChaC-like protein PQ-loop PF04193.9 CDF88508.1 - 1.2e-23 82.4 9.1 2.9e-19 68.3 1.2 2.8 2 0 0 2 2 2 2 PQ loop repeat ABC2_membrane_5 PF13346.1 CDF88508.1 - 0.0023 17.2 16.2 0.0044 16.3 5.5 2.1 1 1 1 2 2 2 2 ABC-2 family transporter protein Rad4 PF03835.10 CDF88509.1 - 2.2e-30 104.9 0.5 7.2e-30 103.2 0.3 2.0 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.4 CDF88509.1 - 3.5e-24 84.2 0.2 7e-24 83.3 0.1 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.4 CDF88509.1 - 2.4e-18 65.4 0.1 4.8e-18 64.4 0.1 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.4 CDF88509.1 - 1.2e-08 35.0 5.2 1.5e-08 34.8 0.1 3.2 3 0 0 3 3 3 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.14 CDF88509.1 - 3.3e-05 24.0 0.1 0.00093 19.3 0.0 2.9 3 0 0 3 3 3 1 Transglutaminase-like superfamily SPT2 PF08243.6 CDF88510.1 - 4.8e-29 101.0 29.6 4.8e-29 101.0 20.5 2.7 2 1 1 3 3 3 1 SPT2 chromatin protein Slu7 PF11708.3 CDF88511.1 - 3.3e-40 138.3 8.1 6e-40 137.4 5.6 1.4 1 0 0 1 1 1 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC PF00098.18 CDF88511.1 - 0.00013 21.7 0.3 0.00025 20.8 0.1 1.6 2 0 0 2 2 2 1 Zinc knuckle ProQ PF04352.8 CDF88511.1 - 0.002 17.7 0.6 0.0066 16.0 0.0 2.1 3 0 0 3 3 3 1 ProQ/FINO family Nop52 PF05997.7 CDF88512.1 - 2.7e-65 219.8 5.3 3.2e-65 219.6 3.7 1.0 1 0 0 1 1 1 1 Nucleolar protein,Nop52 TAN PF11640.3 CDF88512.1 - 0.0045 16.7 0.1 0.41 10.3 0.0 2.3 2 0 0 2 2 2 2 Telomere-length maintenance and DNA damage repair SecE PF00584.15 CDF88513.1 - 2.3e-10 39.9 0.0 2.5e-10 39.7 0.0 1.0 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex CBFD_NFYB_HMF PF00808.18 CDF88514.1 - 2.2e-10 40.4 0.1 3.1e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CLIP PF12032.3 CDF88514.1 - 0.052 13.6 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Regulatory CLIP domain of proteinases Ppx-GppA PF02541.11 CDF88514.1 - 0.1 11.7 0.0 0.19 10.8 0.0 1.4 1 1 0 1 1 1 0 Ppx/GppA phosphatase family DUF846 PF05832.7 CDF88516.1 - 1.5e-45 154.4 4.1 1.5e-45 154.4 2.8 1.4 2 0 0 2 2 2 1 Eukaryotic protein of unknown function (DUF846) Kelch_1 PF01344.20 CDF88516.1 - 0.048 13.2 0.3 0.1 12.1 0.2 1.5 1 0 0 1 1 1 0 Kelch motif FA_desaturase PF00487.19 CDF88516.1 - 0.53 9.6 8.5 0.072 12.5 2.3 1.8 1 1 1 2 2 2 0 Fatty acid desaturase Methyltransf_8 PF05148.10 CDF88517.1 - 6.8e-66 222.0 2.6 1.2e-64 217.9 0.2 3.0 1 1 1 2 2 2 1 Hypothetical methyltransferase Methyltransf_11 PF08241.7 CDF88517.1 - 3.1e-08 34.0 0.2 6.6e-07 29.7 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDF88517.1 - 0.00086 18.9 0.1 0.025 14.1 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDF88517.1 - 0.017 15.5 0.5 0.2 12.0 0.0 2.8 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_32 PF13679.1 CDF88517.1 - 0.018 14.7 0.5 0.17 11.5 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Stn1 PF10451.4 CDF88518.1 - 7e-54 182.3 1.4 7e-53 179.0 1.0 2.0 1 1 0 1 1 1 1 Telomere regulation protein Stn1 Stn1_C PF12659.2 CDF88518.1 - 6.3e-28 97.1 0.1 1.2e-27 96.2 0.0 1.5 1 0 0 1 1 1 1 Telomere capping C-terminal wHTH Transthyretin PF00576.16 CDF88519.1 - 2.8e-29 101.2 0.2 7.6e-21 74.0 0.3 2.4 1 1 0 2 2 2 2 HIUase/Transthyretin family DUF2606 PF10794.4 CDF88519.1 - 0.0042 16.5 0.1 0.2 11.0 0.0 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF2606) DDE_1 PF03184.14 CDF88520.1 - 1.3e-76 256.5 0.9 2e-76 255.9 0.6 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.11 CDF88520.1 - 2.9e-14 52.6 2.1 7.2e-14 51.3 0.0 2.7 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain HTH_32 PF13565.1 CDF88520.1 - 0.064 14.0 0.0 0.64 10.8 0.1 2.7 2 0 0 2 2 2 0 Homeodomain-like domain Clathrin PF00637.15 CDF88521.1 - 6.9e-25 87.3 3.5 1.9e-24 85.9 0.3 2.4 2 0 0 2 2 2 1 Region in Clathrin and VPS Vps39_1 PF10366.4 CDF88521.1 - 0.00028 20.8 1.0 0.0011 18.9 0.1 2.4 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 WD40 PF00400.27 CDF88521.1 - 0.00035 20.3 0.3 0.0014 18.4 0.2 2.1 1 0 0 1 1 1 1 WD domain, G-beta repeat TPR_17 PF13431.1 CDF88521.1 - 0.012 15.8 0.0 0.1 12.8 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Tbf5 PF06331.7 CDF88522.1 - 3.2e-29 100.4 0.1 3.7e-29 100.3 0.1 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 Arena_glycoprot PF00798.13 CDF88522.1 - 0.13 10.6 0.0 0.14 10.5 0.0 1.0 1 0 0 1 1 1 0 Arenavirus glycoprotein Sec34 PF04136.10 CDF88523.1 - 1.2e-21 77.0 4.0 1.2e-21 77.0 2.7 2.7 2 0 0 2 2 2 1 Sec34-like family Med2 PF11214.3 CDF88523.1 - 0.012 15.6 0.0 0.12 12.4 0.0 2.9 1 0 0 1 1 1 0 Mediator complex subunit 2 zf-C4H2 PF10146.4 CDF88523.1 - 0.31 11.0 2.0 0.39 10.6 0.3 2.0 2 0 0 2 2 2 0 Zinc finger-containing protein Val_tRNA-synt_C PF10458.4 CDF88524.1 - 7.1 6.7 12.3 14 5.8 0.3 3.8 3 1 0 3 3 3 0 Valyl tRNA synthetase tRNA binding arm UPF0160 PF03690.8 CDF88525.1 - 4e-122 407.6 0.0 4.6e-122 407.4 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) RhoGAP PF00620.22 CDF88526.1 - 1.5e-38 131.7 0.4 6.9e-38 129.6 0.3 2.2 1 0 0 1 1 1 1 RhoGAP domain RasGEF PF00617.14 CDF88526.1 - 8.3e-22 77.8 0.2 2.1e-19 70.0 0.0 3.0 2 0 0 2 2 2 2 RasGEF domain RasGEF_N PF00618.15 CDF88526.1 - 2.7e-17 62.7 3.2 9.2e-17 61.0 0.2 3.3 3 0 0 3 3 3 1 RasGEF N-terminal motif 60KD_IMP PF02096.15 CDF88527.1 - 7.8e-38 130.1 1.0 7.8e-38 130.1 0.7 1.9 2 0 0 2 2 2 1 60Kd inner membrane protein PET122 PF05476.6 CDF88528.1 - 1.3e-90 303.3 3.6 1.5e-90 303.0 2.5 1.0 1 0 0 1 1 1 1 PET122 Aminotran_1_2 PF00155.16 CDF88529.1 - 3.2e-18 65.8 0.0 4e-18 65.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.2 CDF88529.1 - 2.1e-05 23.2 0.0 3e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase UCH PF00443.24 CDF88531.1 - 5.3e-55 186.4 5.6 1.2e-54 185.1 3.9 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Pro_3_hydrox_C PF05373.6 CDF88531.1 - 0.053 13.5 0.1 0.19 11.8 0.1 1.9 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal CUE PF02845.11 CDF88532.1 - 4e-08 32.5 0.6 1.5e-07 30.7 0.0 2.3 2 0 0 2 2 2 1 CUE domain UBA_4 PF14555.1 CDF88532.1 - 0.021 14.3 0.0 0.04 13.4 0.0 1.5 1 0 0 1 1 1 0 UBA-like domain GvpL_GvpF PF06386.6 CDF88532.1 - 0.023 14.3 0.6 0.023 14.3 0.4 1.9 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF WD40 PF00400.27 CDF88534.1 - 4.2e-15 54.9 8.4 5.7e-05 22.8 0.1 5.8 6 0 0 6 6 6 3 WD domain, G-beta repeat Rax2 PF12768.2 CDF88534.1 - 0.0011 18.2 0.2 0.0021 17.3 0.1 1.4 1 0 0 1 1 1 1 Cortical protein marker for cell polarity DASH_Dad3 PF08656.5 CDF88535.1 - 1.9e-25 88.3 0.2 2.2e-25 88.1 0.2 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad3 DUF1546 PF07571.8 CDF88536.1 - 8.6e-31 105.9 0.0 2.1e-30 104.6 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1546) TAF PF02969.12 CDF88536.1 - 1.4e-29 101.8 0.4 2.6e-29 100.9 0.3 1.5 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.19 CDF88536.1 - 9.7e-06 25.6 0.1 0.00019 21.4 0.1 2.3 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TAF4 PF05236.9 CDF88536.1 - 0.0032 16.7 0.0 0.0055 16.0 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family CBFD_NFYB_HMF PF00808.18 CDF88536.1 - 0.0046 16.9 0.3 0.015 15.3 0.1 2.1 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.10 CDF88536.1 - 0.021 14.6 0.9 0.044 13.5 0.1 1.9 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.1 CDF88536.1 - 0.026 14.6 0.2 0.78 9.9 0.1 2.8 2 0 0 2 2 2 0 Kinetochore component CENP-S SLD3 PF08639.5 CDF88537.1 - 1.8e-70 237.9 20.2 5.7e-70 236.3 14.0 1.6 1 1 0 1 1 1 1 DNA replication regulator SLD3 KH_1 PF00013.24 CDF88538.1 - 1e-33 114.7 3.6 2.2e-11 43.2 0.5 3.3 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 CDF88538.1 - 7.6e-27 92.4 3.9 1.9e-09 36.9 0.9 3.4 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 CDF88538.1 - 7e-11 41.5 2.0 0.0071 15.8 0.0 3.7 3 1 0 3 3 3 3 KH domain KH_4 PF13083.1 CDF88538.1 - 8e-10 38.2 0.5 0.0096 15.5 0.0 3.5 3 0 0 3 3 3 2 KH domain DUF354 PF04007.7 CDF88538.1 - 0.00026 19.9 0.9 0.16 10.7 0.0 2.7 2 1 0 2 2 2 2 Protein of unknown function (DUF354) Retinin_C PF04527.7 CDF88538.1 - 3.2 7.7 5.5 13 5.9 3.8 2.0 1 1 0 1 1 1 0 Drosophila Retinin like protein BCNT PF07572.7 CDF88539.1 - 3.3e-25 87.8 0.3 3.3e-25 87.8 0.2 2.1 2 0 0 2 2 2 1 Bucentaur or craniofacial development OPT PF03169.10 CDF88540.1 - 2.2e-154 515.2 18.5 2.5e-154 515.1 12.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein CBS PF00571.23 CDF88541.1 - 3.9e-27 93.7 4.7 6.9e-12 44.9 0.1 4.3 4 0 0 4 4 4 4 CBS domain HTH_9 PF08221.6 CDF88541.1 - 0.18 11.7 2.6 1.2 9.0 0.1 3.0 4 0 0 4 4 4 0 RNA polymerase III subunit RPC82 helix-turn-helix domain WD40 PF00400.27 CDF88542.1 - 1.6e-21 75.2 15.9 3.4e-07 29.8 0.2 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ABC1 PF03109.11 CDF88544.1 - 5.6e-37 126.3 0.0 1.1e-36 125.3 0.0 1.5 1 0 0 1 1 1 1 ABC1 family HA2 PF04408.18 CDF88545.1 - 9.3e-27 93.0 0.0 2.3e-26 91.7 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 CDF88545.1 - 9.7e-25 86.6 0.0 2.2e-24 85.4 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 CDF88545.1 - 5.4e-11 42.2 0.0 1.6e-10 40.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 CDF88545.1 - 2.2e-08 33.7 0.3 4.1e-08 32.9 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 CDF88545.1 - 5.1e-06 26.6 0.1 2e-05 24.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.17 CDF88545.1 - 4.5e-05 22.9 0.1 0.00011 21.7 0.1 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain Flavi_DEAD PF07652.9 CDF88545.1 - 0.0019 17.9 0.1 0.0038 16.9 0.1 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain ResIII PF04851.10 CDF88545.1 - 0.0025 17.6 3.2 0.017 14.9 0.0 2.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_23 PF13476.1 CDF88545.1 - 0.0041 17.4 0.0 0.16 12.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 CDF88545.1 - 0.015 14.2 0.0 0.028 13.3 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.1 CDF88545.1 - 0.02 14.4 0.0 0.044 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.11 CDF88545.1 - 0.1 11.8 0.0 0.35 10.0 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_29 PF13555.1 CDF88545.1 - 0.13 11.8 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Cast PF10174.4 CDF88546.1 - 0.027 12.5 0.3 0.032 12.3 0.2 1.0 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone Nab2 PF11517.3 CDF88547.1 - 2.1e-45 153.2 3.4 3.1e-45 152.6 2.4 1.2 1 0 0 1 1 1 1 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) zf-CCCH_2 PF14608.1 CDF88547.1 - 1.3e-15 56.6 66.9 1.1e-05 25.2 3.5 7.5 7 1 0 7 7 7 6 Zinc finger C-x8-C-x5-C-x3-H type DUF2508 PF10704.4 CDF88547.1 - 0.018 15.2 0.0 0.039 14.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2508) Ribosomal_S5 PF00333.15 CDF88548.1 - 3.1e-28 97.3 2.8 3.1e-28 97.3 1.9 1.7 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.10 CDF88548.1 - 6.5e-22 76.6 0.1 1.1e-21 75.8 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain FoP_duplication PF13865.1 CDF88548.1 - 5.3 7.5 9.0 0.34 11.3 2.7 1.6 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 Perilipin PF03036.11 CDF88549.1 - 0.035 12.9 0.2 0.048 12.4 0.2 1.1 1 0 0 1 1 1 0 Perilipin family ATG_C PF09333.6 CDF88549.1 - 0.077 13.1 0.1 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 ATG C terminal domain Mon1 PF03164.9 CDF88550.1 - 9.2e-125 416.4 0.3 1.1e-124 416.2 0.2 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 GATA PF00320.22 CDF88551.1 - 3.3e-14 51.9 2.5 6.5e-14 50.9 1.7 1.5 1 0 0 1 1 1 1 GATA zinc finger FadA PF09403.5 CDF88551.1 - 0.055 13.4 1.1 0.079 12.9 0.2 1.6 2 0 0 2 2 2 0 Adhesion protein FadA Glyco_hydro_31 PF01055.21 CDF88552.1 - 2.2e-131 438.7 0.0 4.8e-131 437.6 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.1 CDF88552.1 - 2.9e-22 78.2 1.8 1.6e-21 75.8 0.2 2.8 3 0 0 3 3 3 1 Galactose mutarotase-like Gemini_AL2 PF01440.11 CDF88552.1 - 0.021 14.8 0.1 0.045 13.8 0.1 1.4 1 0 0 1 1 1 0 Geminivirus AL2 protein GIY-YIG PF01541.19 CDF88553.1 - 8.1e-08 32.5 0.0 2e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 GIY-YIG catalytic domain FANCL_C PF11793.3 CDF88553.1 - 0.0015 18.4 1.9 0.0034 17.3 1.3 1.6 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_2 PF13639.1 CDF88553.1 - 0.029 14.1 2.3 0.074 12.8 1.6 1.7 1 1 0 1 1 1 0 Ring finger domain zinc_ribbon_5 PF13719.1 CDF88553.1 - 0.037 13.6 0.3 5.3 6.7 0.0 3.1 2 1 0 2 2 2 0 zinc-ribbon domain zf-RING_5 PF14634.1 CDF88553.1 - 0.084 12.6 4.2 0.2 11.4 2.9 1.7 1 0 0 1 1 1 0 zinc-RING finger domain Poxvirus_B22R_C PF13168.1 CDF88553.1 - 0.11 11.7 0.1 0.16 11.2 0.1 1.2 1 0 0 1 1 1 0 Poxvirus B22R protein C-terminal zf-RING-like PF08746.6 CDF88553.1 - 0.11 12.4 3.0 0.15 12.0 0.3 2.3 2 0 0 2 2 2 0 RING-like domain AAA_2 PF07724.9 CDF88554.1 - 1.8e-34 119.1 0.3 4.2e-34 117.9 0.2 1.6 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 CDF88554.1 - 3.5e-14 53.1 0.2 7.6e-14 52.0 0.2 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 CDF88554.1 - 8.5e-09 35.1 0.0 2.2e-08 33.8 0.0 1.7 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.9 CDF88554.1 - 1.4e-06 28.1 0.0 3.2e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 CDF88554.1 - 8.2e-06 25.1 0.3 0.0015 17.7 0.1 2.8 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 CDF88554.1 - 0.00061 19.3 0.0 0.096 12.1 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain IstB_IS21 PF01695.12 CDF88554.1 - 0.001 18.5 0.0 0.0021 17.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein DEAD PF00270.24 CDF88554.1 - 0.0011 18.5 1.1 0.076 12.5 0.1 3.2 2 1 1 3 3 3 1 DEAD/DEAH box helicase AAA_22 PF13401.1 CDF88554.1 - 0.0013 18.8 1.1 0.023 14.8 0.1 3.1 3 1 0 3 3 3 1 AAA domain RuvB_N PF05496.7 CDF88554.1 - 0.0038 16.2 0.1 0.016 14.2 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 CDF88554.1 - 0.0057 16.5 0.4 0.022 14.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CDF88554.1 - 0.0088 16.0 0.6 0.082 12.8 0.1 2.3 1 1 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 CDF88554.1 - 0.0088 16.8 1.4 0.045 14.5 0.0 2.7 3 1 0 3 3 3 1 AAA domain Sigma54_activ_2 PF14532.1 CDF88554.1 - 0.015 15.3 0.0 0.045 13.7 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.1 CDF88554.1 - 0.023 14.2 1.1 0.034 13.7 0.1 1.8 2 0 0 2 2 2 0 AAA domain PhoH PF02562.11 CDF88554.1 - 0.029 13.6 0.0 0.058 12.6 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.22 CDF88554.1 - 0.21 11.8 1.8 0.31 11.3 0.7 2.0 1 1 0 1 1 1 0 ABC transporter Methyltransf_11 PF08241.7 CDF88555.1 - 0.001 19.4 0.0 0.0032 17.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDF88555.1 - 0.014 15.1 0.0 0.025 14.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Dot_icm_IcmQ PF09475.5 CDF88555.1 - 0.074 12.2 0.1 0.79 8.9 0.0 2.4 2 0 0 2 2 2 0 Dot/Icm secretion system protein (dot_icm_IcmQ) MTHFR PF02219.12 CDF88556.1 - 4.2e-119 396.8 0.0 5.5e-119 396.5 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Tyr-DNA_phospho PF06087.7 CDF88557.1 - 8.8e-94 314.6 0.9 1e-93 314.4 0.7 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.1 CDF88557.1 - 5.2e-05 22.9 0.0 0.002 17.8 0.0 2.3 2 0 0 2 2 2 1 PLD-like domain AMP-binding PF00501.23 CDF88558.1 - 3.5e-73 246.3 0.0 4.9e-73 245.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CDF88558.1 - 1.2e-16 61.3 0.1 3.3e-16 59.9 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Transket_pyr PF02779.19 CDF88559.1 - 1.4e-46 158.2 0.0 2.2e-46 157.5 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 CDF88559.1 - 1.4e-38 131.5 1.3 5.3e-38 129.7 0.1 2.3 2 1 1 3 3 3 1 Transketolase, C-terminal domain Acatn PF13000.2 CDF88560.1 - 6.1e-249 827.1 17.2 6.9e-249 826.9 11.9 1.0 1 0 0 1 1 1 1 Acetyl-coenzyme A transporter 1 Scs3p PF10261.4 CDF88561.1 - 1.2e-63 214.3 7.6 1.6e-63 213.9 5.2 1.1 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM SpoIISA_toxin PF14171.1 CDF88561.1 - 0.024 13.8 2.2 0.049 12.8 1.5 1.5 1 0 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system Med31 PF05669.7 CDF88562.1 - 3.5e-33 113.3 0.4 4e-33 113.2 0.3 1.1 1 0 0 1 1 1 1 SOH1 CPSase_L_D2 PF02786.12 CDF88563.1 - 2.8e-82 275.0 0.4 4.6e-82 274.3 0.3 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.13 CDF88563.1 - 3e-67 225.8 0.0 5.1e-67 225.1 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain CPSase_L_chain PF00289.17 CDF88563.1 - 2.2e-35 121.0 0.0 5.6e-35 119.7 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 CDF88563.1 - 6.1e-32 109.7 0.0 6.1e-31 106.5 0.0 2.3 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.14 CDF88563.1 - 2e-28 99.6 0.7 4.6e-28 98.4 0.0 1.9 2 0 0 2 2 2 1 HMGL-like Biotin_lipoyl PF00364.17 CDF88563.1 - 1.1e-18 66.6 5.0 1.1e-18 66.6 3.5 2.7 2 0 0 2 2 2 1 Biotin-requiring enzyme ATPgrasp_Ter PF15632.1 CDF88563.1 - 7.2e-18 64.4 0.0 2.7e-17 62.5 0.0 1.9 2 1 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_4 PF13535.1 CDF88563.1 - 1.8e-14 53.9 0.2 3.3e-14 53.0 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.1 CDF88563.1 - 9e-10 38.0 4.5 0.00029 20.4 0.2 2.9 1 1 1 2 2 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.8 CDF88563.1 - 5.6e-07 29.1 0.0 1.2e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 CDF88563.1 - 3.5e-05 23.2 0.0 7.2e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain HlyD_3 PF13437.1 CDF88563.1 - 0.00013 22.2 1.1 0.11 12.8 0.0 3.2 2 0 0 2 2 2 1 HlyD family secretion protein ATP-grasp_3 PF02655.9 CDF88563.1 - 0.00013 21.8 0.0 0.00033 20.5 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain HlyD PF00529.15 CDF88563.1 - 0.00018 20.9 1.6 0.08 12.2 0.1 2.3 2 0 0 2 2 2 2 HlyD family secretion protein RimK PF08443.6 CDF88563.1 - 0.00019 20.9 0.0 0.00096 18.6 0.0 2.0 1 1 0 1 1 1 1 RimK-like ATP-grasp domain HlyD_2 PF12700.2 CDF88563.1 - 0.00073 18.7 1.3 0.15 11.2 0.1 2.3 1 1 1 2 2 2 2 HlyD family secretion protein RnfC_N PF13375.1 CDF88563.1 - 0.021 14.5 2.3 0.47 10.1 0.5 3.1 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain Serine_rich PF08824.5 CDF88563.1 - 0.086 12.5 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Serine rich protein interaction domain DASH_Duo1 PF08651.5 CDF88564.1 - 2.5e-24 84.6 2.5 2.7e-24 84.5 0.5 1.9 2 0 0 2 2 2 1 DASH complex subunit Duo1 Tweety PF04906.8 CDF88564.1 - 0.011 14.1 0.3 0.014 13.8 0.2 1.2 1 0 0 1 1 1 0 Tweety APG12 PF04110.8 CDF88565.1 - 1.1e-28 99.2 0.1 1.7e-28 98.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Kinetochor_Ybp2 PF08568.5 CDF88566.1 - 3.9e-155 517.6 12.6 4.3e-155 517.5 8.7 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin HUN PF08729.5 CDF88567.1 - 4e-14 52.2 0.0 1.1e-13 50.8 0.0 1.8 1 0 0 1 1 1 1 HPC2 and ubinuclein domain Nucleoplasmin PF03066.10 CDF88567.1 - 0.41 10.1 12.3 1.4 8.4 8.5 1.9 1 0 0 1 1 1 0 Nucleoplasmin BCDHK_Adom3 PF10436.4 CDF88568.1 - 5e-35 120.4 1.1 8.9e-35 119.6 0.8 1.4 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.21 CDF88568.1 - 1.4e-09 37.6 0.0 1.3e-08 34.5 0.0 2.2 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase UQ_con PF00179.21 CDF88569.1 - 1.2e-50 170.5 0.1 1.4e-50 170.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CDF88569.1 - 6.1e-06 26.0 0.0 9.3e-06 25.4 0.0 1.3 1 1 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 CDF88569.1 - 0.023 14.5 0.2 0.077 12.8 0.1 1.8 1 1 0 1 1 1 0 RWD domain UEV PF05743.8 CDF88569.1 - 0.031 13.9 0.0 0.054 13.1 0.0 1.4 1 0 0 1 1 1 0 UEV domain CBS PF00571.23 CDF88571.1 - 6.9e-24 83.3 0.8 1.6e-05 24.5 0.1 5.3 5 0 0 5 5 5 5 CBS domain PAT1 PF09770.4 CDF88571.1 - 0.19 9.9 18.9 0.38 8.9 13.1 1.4 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Spc7_N PF15402.1 CDF88571.1 - 0.57 8.1 10.0 0.98 7.3 4.4 2.0 2 0 0 2 2 2 0 N-terminus of kinetochore NMS complex subunit Spc7 FA_desaturase PF00487.19 CDF88572.1 - 7.7e-20 71.4 15.9 7.7e-20 71.4 11.0 1.8 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.23 CDF88572.1 - 7.1e-14 51.3 0.0 1.7e-13 50.1 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_7 PF13241.1 CDF88573.1 - 9.3e-25 86.8 0.0 1.5e-24 86.2 0.0 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.1 CDF88573.1 - 3.4e-17 61.5 0.0 6.4e-17 60.6 0.0 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.1 CDF88573.1 - 3.3e-14 51.5 0.0 5.7e-14 50.7 0.0 1.4 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central 2-Hacid_dh_C PF02826.14 CDF88573.1 - 0.035 13.2 0.0 0.055 12.6 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 CDF88573.1 - 0.037 14.1 0.0 0.081 13.0 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sec34 PF04136.10 CDF88575.1 - 0.0041 16.8 0.4 0.0091 15.7 0.3 1.7 1 0 0 1 1 1 1 Sec34-like family DUF972 PF06156.8 CDF88575.1 - 0.4 11.0 3.8 0.35 11.2 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Med28 PF11594.3 CDF88575.1 - 4.2 7.6 7.0 32 4.8 1.9 2.7 1 1 0 2 2 2 0 Mediator complex subunit 28 APG6 PF04111.7 CDF88575.1 - 4.4 6.2 11.5 0.54 9.2 5.1 1.5 2 0 0 2 2 2 0 Autophagy protein Apg6 Cornichon PF03311.9 CDF88576.1 - 3.1e-51 172.8 13.7 3.5e-51 172.6 9.5 1.0 1 0 0 1 1 1 1 Cornichon protein Caa3_CtaG PF09678.5 CDF88576.1 - 0.088 11.7 0.1 0.088 11.7 0.1 1.9 3 0 0 3 3 3 0 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) Bac_export_2 PF01312.14 CDF88576.1 - 1.2 7.9 6.5 0.97 8.2 3.8 1.4 1 1 0 1 1 1 0 FlhB HrpN YscU SpaS Family Aldo_ket_red PF00248.16 CDF88577.1 - 7.1e-66 221.9 0.0 8.1e-66 221.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family CobD_Cbib PF03186.8 CDF88578.1 - 0.15 11.0 1.9 0.16 11.0 1.3 1.0 1 0 0 1 1 1 0 CobD/Cbib protein Pyridoxal_deC PF00282.14 CDF88579.1 - 6.2e-52 176.2 0.0 9.7e-52 175.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain SAM_decarbox PF01536.11 CDF88580.1 - 2.2e-111 371.7 3.5 2.5e-111 371.5 2.5 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase zf-RING_2 PF13639.1 CDF88581.1 - 1.1e-08 34.6 7.1 1.1e-08 34.6 4.9 2.2 2 0 0 2 2 1 1 Ring finger domain zf-rbx1 PF12678.2 CDF88581.1 - 1.3e-07 31.5 2.7 3.6e-07 30.1 1.9 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger FANCL_C PF11793.3 CDF88581.1 - 1.1e-05 25.2 4.2 1.1e-05 25.2 2.9 2.2 2 0 0 2 2 2 1 FANCL C-terminal domain zf-Apc11 PF12861.2 CDF88581.1 - 0.00073 19.3 1.2 0.0024 17.6 0.8 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.2 CDF88581.1 - 0.0045 17.0 6.2 0.012 15.6 4.3 1.8 1 0 0 1 1 1 1 RING-variant domain zf-C3HC4 PF00097.20 CDF88581.1 - 0.029 14.0 11.6 0.059 13.0 5.6 2.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.6 CDF88581.1 - 0.15 12.0 6.6 0.34 10.9 4.6 1.7 1 0 0 1 1 1 0 RING-like domain EST1 PF10374.4 CDF88581.1 - 0.28 11.1 7.9 0.97 9.4 0.1 4.1 3 1 0 3 3 3 0 Telomerase activating protein Est1 zf-C3HC4_3 PF13920.1 CDF88581.1 - 0.56 9.9 8.9 1.2 8.8 3.3 3.1 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-UDP PF14569.1 CDF88581.1 - 0.65 9.7 2.6 9.3 6.0 0.2 2.4 1 1 1 2 2 2 0 Zinc-binding RING-finger zf-C3HC4_2 PF13923.1 CDF88581.1 - 7.5 6.6 18.3 0.07 13.1 5.7 2.7 3 0 0 3 3 2 0 Zinc finger, C3HC4 type (RING finger) Glyco_transf_8 PF01501.15 CDF88582.1 - 2.8e-06 26.8 11.7 7.4e-06 25.4 6.1 2.7 2 1 0 2 2 2 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.3 CDF88582.1 - 0.0038 16.6 0.9 0.0076 15.6 0.6 1.5 1 0 0 1 1 1 1 Mannosyltransferase putative RRM_1 PF00076.17 CDF88583.1 - 2.8e-24 84.5 0.0 6.1e-13 48.2 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF88583.1 - 8e-22 76.9 0.0 4.3e-13 49.0 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF88583.1 - 1.2e-11 44.3 0.1 0.00016 21.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) COX6B PF02297.12 CDF88584.1 - 4.3e-23 81.1 5.2 5.7e-23 80.7 3.6 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Pet191_N PF10203.4 CDF88584.1 - 0.01 15.8 1.9 0.034 14.2 1.3 1.7 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Trp_DMAT PF11991.3 CDF88584.1 - 0.042 13.0 0.1 0.052 12.7 0.0 1.1 1 0 0 1 1 1 0 Tryptophan dimethylallyltransferase Bac_rhodopsin PF01036.13 CDF88585.1 - 1.7e-65 220.4 22.4 2.1e-65 220.1 15.5 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein DUF2101 PF09874.4 CDF88585.1 - 1.8 7.9 6.7 4.9 6.5 4.6 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2101) SUN PF03856.8 CDF88586.1 - 6.4e-82 274.5 19.6 7.6e-82 274.3 13.6 1.0 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) DUF3846 PF12957.2 CDF88586.1 - 0.066 12.9 0.1 12 5.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3846) Cation_efflux PF01545.16 CDF88587.1 - 1.7e-81 273.4 3.2 2.3e-81 273.0 2.2 1.2 1 0 0 1 1 1 1 Cation efflux family NDUF_C2 PF06374.6 CDF88587.1 - 0.027 14.4 0.0 0.059 13.3 0.0 1.5 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) PGPGW PF09656.5 CDF88587.1 - 1.9 7.8 4.5 0.79 9.0 0.0 2.4 2 0 0 2 2 2 0 Putative transmembrane protein (PGPGW) Iso_dh PF00180.15 CDF88588.1 - 0.027 13.4 0.5 0.086 11.7 0.0 2.0 2 0 0 2 2 2 0 Isocitrate/isopropylmalate dehydrogenase DENN PF02141.16 CDF88588.1 - 0.053 13.2 0.7 1.8 8.2 0.0 2.5 2 1 0 2 2 2 0 DENN (AEX-3) domain UPF0113 PF03657.8 CDF88588.1 - 0.13 11.8 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0113) Ribosomal_L18ae PF01775.12 CDF88589.1 - 2.4e-57 192.1 2.2 2.4e-57 192.1 1.6 1.3 2 0 0 2 2 2 1 Ribosomal L18ae/LX protein domain CTP_transf_1 PF01148.15 CDF88590.1 - 2.7e-21 76.3 6.6 1.2e-18 67.6 2.0 2.1 1 1 1 2 2 2 2 Cytidylyltransferase family Nop PF01798.13 CDF88591.1 - 8.1e-60 200.4 0.5 2.7e-59 198.7 0.3 1.9 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 CDF88591.1 - 1.8e-27 94.8 1.2 2.5e-27 94.4 0.1 1.9 2 0 0 2 2 2 1 NOSIC (NUC001) domain NOP5NT PF08156.8 CDF88591.1 - 1.4e-17 63.6 1.2 1.4e-17 63.6 0.8 3.3 2 1 0 2 2 2 1 NOP5NT (NUC127) domain Cwf_Cwc_15 PF04889.7 CDF88591.1 - 6.5 6.3 48.8 1.1 8.8 31.3 1.5 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein SART-1 PF03343.8 CDF88592.1 - 1.2e-45 156.0 46.0 2.2e-39 135.3 31.9 4.2 1 1 0 1 1 1 1 SART-1 family TPT PF03151.11 CDF88593.1 - 1.1e-22 80.3 5.8 1.1e-22 80.3 4.0 2.6 2 1 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.15 CDF88593.1 - 4e-06 26.8 20.3 0.00012 22.1 3.9 3.7 3 1 1 4 4 4 2 EamA-like transporter family UAA PF08449.6 CDF88593.1 - 0.33 9.8 20.0 1.8 7.4 13.9 2.2 1 1 0 1 1 1 0 UAA transporter family PIRT PF15099.1 CDF88593.1 - 1 8.5 7.7 2.5 7.3 0.0 2.9 3 0 0 3 3 3 0 Phosphoinositide-interacting protein family Mito_carr PF00153.22 CDF88594.1 - 2.1e-28 97.8 4.1 3.4e-11 42.7 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF2034 PF10356.4 CDF88595.1 - 1.4e-54 184.1 0.0 1.6e-54 183.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2034) Mrr_cat PF04471.7 CDF88595.1 - 0.00028 20.6 0.0 0.086 12.6 0.0 2.2 2 0 0 2 2 2 2 Restriction endonuclease Sox_N PF12444.3 CDF88596.1 - 0.033 15.3 2.2 0.038 15.0 1.5 1.1 1 0 0 1 1 1 0 Sox developmental protein N terminal TIMELESS PF04821.9 CDF88596.1 - 0.083 12.1 0.0 0.083 12.1 0.0 1.5 2 0 0 2 2 2 0 Timeless protein Syntaxin-6_N PF09177.6 CDF88596.1 - 0.17 12.3 1.2 0.23 11.8 0.8 1.3 1 0 0 1 1 1 0 Syntaxin 6, N-terminal DUF382 PF04037.8 CDF88597.1 - 2.9e-48 162.9 0.3 2.9e-48 162.9 0.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF382) PSP PF04046.11 CDF88597.1 - 9.1e-20 69.7 2.2 1.6e-19 68.9 1.5 1.4 1 0 0 1 1 1 1 PSP Amidohydro_1 PF01979.15 CDF88598.1 - 6.1e-16 58.9 0.1 4.3e-13 49.6 0.1 3.1 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 CDF88598.1 - 1.5e-15 58.0 0.0 2.1e-15 57.5 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_5 PF13594.1 CDF88598.1 - 7.4e-14 51.3 5.4 1.7e-13 50.1 2.7 2.4 2 0 0 2 2 2 1 Amidohydrolase Urease_alpha PF00449.15 CDF88598.1 - 0.0062 16.6 0.7 0.015 15.4 0.5 1.7 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain D-aminoacyl_C PF07908.7 CDF88598.1 - 0.055 12.7 0.1 0.14 11.4 0.0 1.7 1 0 0 1 1 1 0 D-aminoacylase, C-terminal region Amidohydro_3 PF07969.6 CDF88598.1 - 0.099 11.8 0.0 0.9 8.6 0.1 2.2 2 0 0 2 2 2 0 Amidohydrolase family Ribonuclease_3 PF00636.21 CDF88599.1 - 2.5e-20 72.9 0.5 6.3e-19 68.5 0.0 2.6 2 1 0 2 2 2 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.1 CDF88599.1 - 2.5e-15 56.5 0.0 6.1e-15 55.3 0.0 1.7 1 0 0 1 1 1 1 Ribonuclease-III-like dsrm PF00035.20 CDF88599.1 - 1.6e-05 25.3 0.0 4e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Double-stranded RNA binding motif DUF4611 PF15387.1 CDF88599.1 - 0.7 10.0 6.5 0.47 10.6 1.9 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) SNF2_N PF00176.18 CDF88600.1 - 3.6e-81 272.2 1.1 6.8e-81 271.3 0.8 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.5 CDF88600.1 - 7.9e-42 141.7 2.9 7.9e-42 141.7 2.0 2.7 2 0 0 2 2 2 1 SLIDE HAND PF09110.6 CDF88600.1 - 3.6e-34 117.5 10.0 3.6e-34 117.5 6.9 2.8 3 0 0 3 3 3 1 HAND Helicase_C PF00271.26 CDF88600.1 - 1.2e-16 60.2 0.0 7.3e-16 57.8 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 CDF88600.1 - 5e-08 32.6 0.0 1.9e-07 30.7 0.0 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 CDF88600.1 - 0.33 11.0 3.2 0.43 10.7 0.1 2.9 3 1 0 3 3 3 0 AAA domain RCC1 PF00415.13 CDF88601.1 - 1e-21 76.8 0.7 1.9e-06 27.9 0.0 4.9 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 CDF88601.1 - 7.4e-15 54.1 16.3 5.3e-08 32.2 0.6 5.2 4 1 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.26 CDF88601.1 - 1.3e-10 41.2 1.2 2.7e-08 33.7 0.0 2.8 1 1 1 2 2 2 2 BTB/POZ domain Amidase_5 PF05382.8 CDF88601.1 - 0.29 10.7 4.1 0.22 11.1 0.4 2.6 2 1 1 3 3 3 0 Bacteriophage peptidoglycan hydrolase GATase PF00117.23 CDF88602.1 - 2.7e-44 150.9 0.0 3.9e-44 150.4 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.17 CDF88602.1 - 5.4e-44 148.8 0.0 1e-43 147.9 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain Peptidase_C26 PF07722.8 CDF88602.1 - 1.3e-06 27.9 0.2 0.00022 20.7 0.1 3.0 2 1 0 2 2 2 1 Peptidase C26 DJ-1_PfpI PF01965.19 CDF88602.1 - 0.00017 21.0 0.0 0.00029 20.3 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family Glyco_hydro_46 PF01374.13 CDF88602.1 - 0.0024 17.4 0.0 0.0038 16.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 46 Ank PF00023.25 CDF88602.1 - 0.047 13.5 0.0 4.3 7.3 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeat Leader_CPA1 PF08252.6 CDF88603.1 - 2.5e-14 52.0 0.8 2.7e-14 51.9 0.5 1.0 1 0 0 1 1 1 1 arg-2/CPA1 leader peptide RGS PF00615.14 CDF88604.1 - 9.3e-05 22.5 1.7 0.00047 20.2 1.2 2.1 1 1 0 1 1 1 1 Regulator of G protein signaling domain BOP1NT PF08145.7 CDF88604.1 - 0.0074 16.0 0.1 0.01 15.5 0.1 1.1 1 0 0 1 1 1 1 BOP1NT (NUC169) domain DUF4414 PF14377.1 CDF88604.1 - 0.033 14.1 2.0 0.23 11.3 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4414) Glyco_hydro_76 PF03663.9 CDF88605.1 - 9.5e-148 492.4 16.0 1.2e-147 492.1 11.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 ChAPs PF09295.5 CDF88606.1 - 3.7e-164 546.1 0.0 4.7e-164 545.8 0.0 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_11 PF13414.1 CDF88606.1 - 1.3e-06 27.9 1.1 0.0058 16.2 0.1 2.9 3 0 0 3 3 3 2 TPR repeat TPR_2 PF07719.12 CDF88606.1 - 3e-05 23.6 3.5 0.025 14.4 0.1 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 CDF88606.1 - 0.0001 22.5 1.3 2 9.3 0.0 4.2 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.1 CDF88606.1 - 0.0014 19.2 0.0 3.9 8.2 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 CDF88606.1 - 0.0015 18.1 0.1 2.2 8.2 0.0 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.23 CDF88606.1 - 0.0038 16.7 0.0 1 9.0 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.1 CDF88606.1 - 0.021 15.2 0.1 35 5.1 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Apc3 PF12895.2 CDF88606.1 - 0.061 13.4 5.8 0.96 9.6 0.1 3.1 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 CDF88606.1 - 0.08 13.1 0.0 0.68 10.2 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.1 CDF88606.1 - 0.09 12.6 0.3 10 6.2 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.1 CDF88606.1 - 0.09 12.6 0.1 11 5.8 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 CDF88606.1 - 0.16 12.3 0.3 3.8 7.9 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TFIID-31kDa PF02291.10 CDF88607.1 - 1.4e-53 180.1 0.0 1.7e-53 179.8 0.0 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Pkinase PF00069.20 CDF88608.1 - 6.8e-55 186.0 2.6 8.2e-53 179.1 1.8 2.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF88608.1 - 1.8e-18 66.5 0.0 1.3e-17 63.7 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF88608.1 - 0.029 13.3 0.0 0.31 9.9 0.0 2.1 1 1 0 2 2 2 0 Kinase-like Ycf1 PF05758.7 CDF88608.1 - 3.3 5.3 15.5 11 3.5 10.9 1.7 1 1 0 1 1 1 0 Ycf1 Macoilin PF09726.4 CDF88608.1 - 7.5 4.6 35.1 0.096 10.9 8.0 2.1 2 0 0 2 2 2 0 Transmembrane protein TBCA PF02970.11 CDF88610.1 - 1.2e-25 89.3 14.8 1.4e-25 89.1 10.2 1.0 1 0 0 1 1 1 1 Tubulin binding cofactor A ALIX_LYPXL_bnd PF13949.1 CDF88610.1 - 0.02 13.8 5.4 0.022 13.7 3.7 1.2 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV Lipoprotein_20 PF13942.1 CDF88610.1 - 0.021 14.3 3.3 0.025 14.1 2.3 1.1 1 0 0 1 1 1 0 YfhG lipoprotein Cytochrom_C_2 PF01322.15 CDF88610.1 - 0.033 14.7 0.5 0.041 14.4 0.4 1.1 1 0 0 1 1 1 0 Cytochrome C' IncA PF04156.9 CDF88610.1 - 0.042 13.4 9.9 0.047 13.2 6.9 1.1 1 0 0 1 1 1 0 IncA protein TPR_12 PF13424.1 CDF88610.1 - 0.043 13.7 0.3 0.09 12.7 0.2 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat CENP-Q PF13094.1 CDF88610.1 - 0.05 13.6 9.0 0.089 12.8 6.2 1.4 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit TMF_TATA_bd PF12325.3 CDF88610.1 - 0.18 11.5 11.4 0.25 11.0 7.9 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF342 PF03961.8 CDF88610.1 - 0.19 10.1 7.8 0.19 10.0 5.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF342) EF1G PF00647.14 CDF88610.1 - 0.19 11.4 1.9 0.22 11.2 0.9 1.4 1 1 0 1 1 1 0 Elongation factor 1 gamma, conserved domain HSP70 PF00012.15 CDF88610.1 - 0.3 8.9 7.0 0.3 8.9 4.8 1.0 1 0 0 1 1 1 0 Hsp70 protein rve_2 PF13333.1 CDF88610.1 - 0.3 11.1 2.3 0.43 10.6 0.1 2.1 2 0 0 2 2 2 0 Integrase core domain Troponin PF00992.15 CDF88610.1 - 0.37 10.8 12.3 0.59 10.1 8.5 1.4 1 1 0 1 1 1 0 Troponin Phage_GP20 PF06810.6 CDF88610.1 - 0.44 9.9 13.9 0.62 9.4 9.6 1.3 1 1 0 1 1 1 0 Phage minor structural protein GP20 DUF3166 PF11365.3 CDF88610.1 - 1.1 9.7 7.5 0.14 12.5 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3166) Lipoprotein_6 PF01441.14 CDF88610.1 - 1.1 9.1 6.3 0.87 9.4 0.3 2.0 1 1 1 2 2 2 0 Lipoprotein DUF4463 PF14703.1 CDF88610.1 - 1.6 9.3 9.9 1.1 9.7 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4463) Spectrin PF00435.16 CDF88610.1 - 1.8 8.8 9.4 11 6.4 0.6 2.1 1 1 1 2 2 2 0 Spectrin repeat APG6 PF04111.7 CDF88610.1 - 2.7 6.9 10.8 3.1 6.7 7.5 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 zf-C4H2 PF10146.4 CDF88610.1 - 4.6 7.1 7.7 5.7 6.8 5.3 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein ATP_bind_1 PF03029.12 CDF88612.1 - 6.9e-79 264.7 0.1 9e-79 264.3 0.1 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_10 PF12846.2 CDF88612.1 - 0.0024 17.3 0.0 0.0025 17.2 0.0 1.3 1 1 0 1 1 1 1 AAA-like domain ArgK PF03308.11 CDF88612.1 - 0.0048 15.7 0.0 0.0082 14.9 0.0 1.3 1 0 0 1 1 1 1 ArgK protein AAA_19 PF13245.1 CDF88612.1 - 0.0075 15.9 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 Part of AAA domain MMR_HSR1 PF01926.18 CDF88612.1 - 0.011 15.7 0.0 0.058 13.3 0.0 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_17 PF13207.1 CDF88612.1 - 0.017 15.9 3.5 0.018 15.8 0.1 2.6 2 2 0 2 2 2 0 AAA domain AAA_33 PF13671.1 CDF88612.1 - 0.04 13.7 0.0 0.09 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 CDF88612.1 - 0.075 13.3 0.4 1.2 9.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 CDF88612.1 - 0.12 12.5 0.0 0.38 10.9 0.0 1.9 1 0 0 1 1 1 0 RNA helicase MitMem_reg PF13012.1 CDF88613.1 - 5.2e-38 129.6 3.2 7.6e-38 129.1 1.4 1.9 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.16 CDF88613.1 - 1.9e-27 95.2 0.0 4.2e-27 94.1 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease UbiA PF01040.13 CDF88614.1 - 1.7e-23 83.1 17.2 1.7e-23 83.1 11.9 1.3 1 1 0 1 1 1 1 UbiA prenyltransferase family Hexapep PF00132.19 CDF88615.1 - 7.6e-08 31.5 11.6 0.052 13.0 0.3 3.8 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.2 CDF88615.1 - 2.3e-05 24.5 0.0 3.6e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.7 CDF88615.1 - 0.0058 15.2 0.0 0.0091 14.5 0.0 1.2 1 0 0 1 1 1 1 L-fucokinase NTP_transferase PF00483.18 CDF88615.1 - 0.016 14.5 0.0 0.043 13.0 0.0 1.9 1 1 0 1 1 1 0 Nucleotidyl transferase AAA PF00004.24 CDF88616.1 - 6.6e-43 146.0 0.0 1.4e-42 145.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CDF88616.1 - 7.1e-07 29.3 1.2 2e-05 24.6 0.0 2.9 2 2 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.9 CDF88616.1 - 2.2e-06 27.4 0.1 5.7e-05 22.8 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.9 CDF88616.1 - 1.1e-05 25.4 0.0 3.7e-05 23.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 CDF88616.1 - 3.4e-05 24.0 0.1 0.0021 18.1 0.0 2.6 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 CDF88616.1 - 4.6e-05 22.5 0.0 9.5e-05 21.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 CDF88616.1 - 0.00021 20.9 0.2 0.00043 19.9 0.1 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_17 PF13207.1 CDF88616.1 - 0.00054 20.7 1.8 0.0015 19.3 0.1 2.4 2 1 0 2 2 2 1 AAA domain UPF0079 PF02367.12 CDF88616.1 - 0.0014 18.2 0.0 0.0027 17.3 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 RNA_helicase PF00910.17 CDF88616.1 - 0.0015 18.7 0.0 0.0034 17.5 0.0 1.6 1 0 0 1 1 1 1 RNA helicase IstB_IS21 PF01695.12 CDF88616.1 - 0.0028 17.0 0.1 0.0066 15.8 0.1 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_24 PF13479.1 CDF88616.1 - 0.0046 16.5 0.3 0.0097 15.5 0.2 1.5 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.8 CDF88616.1 - 0.0048 15.6 0.1 0.0085 14.8 0.1 1.3 1 0 0 1 1 1 1 TIP49 C-terminus Mg_chelatase PF01078.16 CDF88616.1 - 0.0055 15.8 0.1 0.011 14.9 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 CDF88616.1 - 0.0055 16.5 0.0 0.015 15.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 CDF88616.1 - 0.0082 15.5 0.9 0.064 12.6 0.4 2.3 1 1 1 2 2 2 1 AAA domain AAA_14 PF13173.1 CDF88616.1 - 0.01 15.7 0.0 0.027 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.7 CDF88616.1 - 0.016 14.3 1.7 0.094 11.7 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_28 PF13521.1 CDF88616.1 - 0.019 14.9 2.7 0.02 14.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.1 CDF88616.1 - 0.022 15.0 2.8 0.053 13.8 0.0 2.6 2 1 0 2 2 2 0 AAA domain PhoH PF02562.11 CDF88616.1 - 0.026 13.7 0.2 0.053 12.7 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein KaiC PF06745.8 CDF88616.1 - 0.027 13.5 1.9 0.051 12.6 0.0 2.3 3 0 0 3 3 3 0 KaiC Sigma54_activat PF00158.21 CDF88616.1 - 0.045 13.2 0.2 0.19 11.2 0.0 2.0 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_3 PF07726.6 CDF88616.1 - 0.071 12.7 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 CDF88616.1 - 0.086 12.4 0.1 0.31 10.6 0.0 2.0 1 1 1 2 2 2 0 NACHT domain AAA_11 PF13086.1 CDF88616.1 - 0.1 12.1 4.7 0.7 9.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.12 CDF88616.1 - 0.13 11.0 0.1 0.13 11.0 0.0 1.6 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 Fib_alpha PF08702.5 CDF88616.1 - 0.31 11.1 3.0 0.66 10.1 2.1 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family V_ATPase_I PF01496.14 CDF88616.1 - 1.4 6.6 3.8 1.9 6.2 2.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_23 PF13476.1 CDF88616.1 - 2.2 8.5 13.0 6.2 7.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain IncA PF04156.9 CDF88616.1 - 8.3 5.9 9.9 15 5.0 6.9 1.4 1 0 0 1 1 1 0 IncA protein DcpS_C PF11969.3 CDF88617.1 - 4.1e-20 72.1 0.8 1.1e-19 70.8 0.5 1.7 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.18 CDF88617.1 - 1.9e-18 66.7 0.3 3.7e-18 65.8 0.1 1.5 2 0 0 2 2 2 1 HIT domain zf-BED PF02892.10 CDF88617.1 - 0.0048 16.6 0.3 0.0099 15.6 0.2 1.5 1 0 0 1 1 1 1 BED zinc finger zf-C2H2_4 PF13894.1 CDF88617.1 - 0.1 12.9 1.8 0.22 11.9 0.3 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger KOW PF00467.24 CDF88618.1 - 2.4e-05 23.8 0.8 4.9e-05 22.8 0.5 1.5 1 0 0 1 1 1 1 KOW motif PAPS_reduct PF01507.14 CDF88619.1 - 5.2e-43 146.8 0.0 6.4e-43 146.5 0.0 1.1 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family DUF1270 PF06900.6 CDF88619.1 - 0.024 14.7 0.0 0.04 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1270) Med10 PF09748.4 CDF88620.1 - 2.3e-45 153.5 1.1 2.7e-45 153.3 0.7 1.0 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex Serine_rich PF08824.5 CDF88620.1 - 0.027 14.1 0.1 0.36 10.5 0.0 2.0 1 1 1 2 2 2 0 Serine rich protein interaction domain D123 PF07065.9 CDF88620.1 - 0.035 13.1 0.3 0.062 12.3 0.1 1.5 2 0 0 2 2 2 0 D123 PBS_linker_poly PF00427.16 CDF88620.1 - 0.048 13.3 0.1 0.1 12.2 0.1 1.6 1 1 0 1 1 1 0 Phycobilisome Linker polypeptide DUF4404 PF14357.1 CDF88620.1 - 0.051 13.9 1.9 6.6 7.2 0.0 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) MogR_DNAbind PF12181.3 CDF88620.1 - 0.057 13.2 0.1 0.1 12.3 0.0 1.5 1 1 0 1 1 1 0 DNA binding domain of the motility gene repressor (MogR) MbeB_N PF04837.7 CDF88620.1 - 0.058 13.4 0.8 8.5 6.5 0.0 3.0 3 0 0 3 3 3 0 MbeB-like, N-term conserved region DASH_Dad2 PF08654.5 CDF88620.1 - 0.2 11.7 2.1 13 5.8 0.0 2.4 3 0 0 3 3 3 0 DASH complex subunit Dad2 NPV_P10 PF05531.7 CDF88620.1 - 0.21 11.8 3.1 6.3 7.1 0.1 2.9 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein BLOC1_2 PF10046.4 CDF88620.1 - 0.21 11.7 1.9 9.9 6.3 0.0 2.5 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cep57_CLD_2 PF14197.1 CDF88620.1 - 2.6 8.0 5.2 0.8 9.6 0.3 2.3 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 WD40 PF00400.27 CDF88621.1 - 0.00099 18.9 0.1 0.034 14.0 0.0 3.3 4 0 0 4 4 4 1 WD domain, G-beta repeat PQQ_2 PF13360.1 CDF88621.1 - 0.026 14.0 0.1 0.37 10.1 0.1 2.3 1 1 0 1 1 1 0 PQQ-like domain PQQ_3 PF13570.1 CDF88621.1 - 0.034 14.4 0.2 10 6.5 0.0 3.9 4 0 0 4 4 4 0 PQQ-like domain Phage_GPL PF05926.6 CDF88622.1 - 0.062 13.1 0.8 0.1 12.4 0.6 1.3 1 0 0 1 1 1 0 Phage head completion protein (GPL) Adeno_terminal PF02459.10 CDF88622.1 - 0.15 10.1 2.6 0.21 9.7 1.8 1.1 1 0 0 1 1 1 0 Adenoviral DNA terminal protein DUF2937 PF11157.3 CDF88622.1 - 0.69 9.2 5.0 0.21 10.9 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) Pga1 PF10333.4 CDF88623.1 - 5.4e-56 189.0 0.5 6.4e-56 188.8 0.3 1.0 1 0 0 1 1 1 1 GPI-Mannosyltransferase II co-activator Peptidase_M14 PF00246.19 CDF88624.1 - 2.8e-69 233.8 0.1 3.7e-69 233.4 0.1 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase Endosulfine PF04667.12 CDF88625.1 - 3.1e-32 110.3 0.2 4e-32 110.0 0.1 1.1 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region INSIG PF07281.7 CDF88626.1 - 2.7e-12 46.4 2.8 4.2e-12 45.8 1.9 1.4 1 1 0 1 1 1 1 Insulin-induced protein (INSIG) WLM PF08325.5 CDF88627.1 - 6.1e-53 179.4 0.2 7.2e-53 179.2 0.1 1.0 1 0 0 1 1 1 1 WLM domain DUF45 PF01863.12 CDF88627.1 - 0.0016 18.2 0.0 0.0029 17.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function DUF45 Peptidase_MA_2 PF13485.1 CDF88627.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Peptidase MA superfamily zf-AN1 PF01428.11 CDF88628.1 - 6.8e-12 45.0 12.5 1.1e-11 44.3 8.7 1.3 1 0 0 1 1 1 1 AN1-like Zinc finger PP2C PF00481.16 CDF88628.1 - 0.052 12.9 0.1 0.069 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein phosphatase 2C Integrin_beta PF00362.13 CDF88628.1 - 0.1 11.4 3.0 0.15 10.9 2.1 1.2 1 0 0 1 1 1 0 Integrin, beta chain YMF19 PF02326.10 CDF88628.1 - 8.5 7.0 7.3 11 6.6 0.9 3.0 2 1 1 3 3 3 0 Plant ATP synthase F0 Pkinase PF00069.20 CDF88629.1 - 1.4e-32 112.8 0.4 2.4e-32 112.1 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF88629.1 - 1e-12 47.7 0.1 2.7e-12 46.3 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Macoilin PF09726.4 CDF88629.1 - 8.2 4.5 11.5 16 3.6 7.9 1.4 1 0 0 1 1 1 0 Transmembrane protein Aldo_ket_red PF00248.16 CDF88630.1 - 1e-35 122.9 0.0 1.3e-35 122.5 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family A_deaminase PF00962.17 CDF88631.1 - 4.6e-87 292.0 0.0 5.2e-87 291.8 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase Aminotran_1_2 PF00155.16 CDF88633.1 - 1.9e-15 56.7 0.0 2.5e-15 56.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DUF4359 PF14271.1 CDF88633.1 - 0.14 12.5 0.0 0.32 11.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4359) Prefoldin_2 PF01920.15 CDF88634.1 - 4.2e-22 77.9 13.5 5e-22 77.6 9.3 1.1 1 0 0 1 1 1 1 Prefoldin subunit V_ATPase_I PF01496.14 CDF88634.1 - 0.0013 16.7 5.4 0.0016 16.4 3.8 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Laminin_II PF06009.7 CDF88634.1 - 0.0016 18.1 0.3 0.0016 18.1 0.2 1.8 2 0 0 2 2 2 1 Laminin Domain II DivIC PF04977.10 CDF88634.1 - 0.0043 16.5 1.5 0.0043 16.5 1.0 2.2 2 0 0 2 2 2 1 Septum formation initiator ATG16 PF08614.6 CDF88634.1 - 0.0059 16.4 1.1 0.0059 16.4 0.7 2.1 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) DUF948 PF06103.6 CDF88634.1 - 0.022 14.6 1.1 0.022 14.6 0.8 1.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Seryl_tRNA_N PF02403.17 CDF88634.1 - 0.025 14.5 7.1 0.2 11.6 0.6 2.1 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain XhlA PF10779.4 CDF88634.1 - 0.051 13.4 1.9 0.051 13.4 1.3 2.0 2 0 0 2 2 2 0 Haemolysin XhlA ADIP PF11559.3 CDF88634.1 - 0.057 13.3 0.4 0.057 13.3 0.3 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding YscO PF07321.7 CDF88634.1 - 0.067 13.0 0.9 0.067 13.0 0.6 2.1 2 0 0 2 2 2 0 Type III secretion protein YscO Nop16 PF09420.5 CDF88634.1 - 0.07 13.2 2.8 0.1 12.7 1.9 1.2 1 1 0 1 1 1 0 Ribosome biogenesis protein Nop16 G6PD_bact PF10786.4 CDF88634.1 - 0.077 12.4 1.9 0.095 12.1 1.3 1.2 1 0 0 1 1 1 0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) DUF4600 PF15372.1 CDF88634.1 - 0.078 13.1 7.2 0.18 12.0 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) DUF3186 PF11382.3 CDF88634.1 - 0.093 11.8 0.1 0.093 11.8 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3186) HemX PF04375.9 CDF88634.1 - 0.12 10.9 3.5 0.15 10.6 2.5 1.1 1 0 0 1 1 1 0 HemX Nup54 PF13874.1 CDF88634.1 - 0.14 11.7 9.6 0.42 10.2 2.3 2.1 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 DUF489 PF04356.7 CDF88634.1 - 0.15 11.6 1.4 0.23 11.0 1.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF489) YvrJ PF12841.2 CDF88634.1 - 0.17 11.1 4.5 2.5 7.4 0.4 3.0 2 1 1 3 3 3 0 YvrJ protein family PspA_IM30 PF04012.7 CDF88634.1 - 0.19 11.0 7.3 0.038 13.3 1.6 1.9 2 0 0 2 2 2 0 PspA/IM30 family GA PF01468.12 CDF88634.1 - 0.19 11.8 0.4 0.19 11.8 0.2 1.8 2 1 0 2 2 1 0 GA module DUF4635 PF15466.1 CDF88634.1 - 0.3 10.3 4.8 0.54 9.5 3.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4635) CASP_C PF08172.7 CDF88634.1 - 0.35 9.8 4.0 0.11 11.5 0.2 2.0 2 0 0 2 2 2 0 CASP C terminal TBPIP PF07106.8 CDF88634.1 - 0.4 10.1 9.6 0.068 12.7 0.9 2.1 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Spc7 PF08317.6 CDF88634.1 - 0.43 9.1 11.9 0.53 8.8 8.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein TMF_DNA_bd PF12329.3 CDF88634.1 - 0.44 10.3 12.2 0.11 12.2 2.6 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding FlaC_arch PF05377.6 CDF88634.1 - 0.66 9.9 8.0 0.5 10.2 1.0 2.7 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Spc24 PF08286.6 CDF88634.1 - 0.73 9.5 7.2 0.95 9.1 0.6 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Prefoldin_3 PF13758.1 CDF88634.1 - 0.84 9.4 6.7 1.5 8.6 4.7 1.5 1 1 0 1 1 1 0 Prefoldin subunit CENP-Q PF13094.1 CDF88634.1 - 0.88 9.5 8.3 1.1 9.2 1.4 2.2 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit APG6 PF04111.7 CDF88634.1 - 0.94 8.4 11.3 0.59 9.1 1.0 2.0 2 0 0 2 2 2 0 Autophagy protein Apg6 Prefoldin PF02996.12 CDF88634.1 - 0.95 9.1 8.1 4.3 7.0 5.6 2.0 1 1 0 1 1 1 0 Prefoldin subunit DUF1949 PF09186.6 CDF88634.1 - 1.2 8.7 4.9 0.43 10.2 0.6 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF1949) DUF1664 PF07889.7 CDF88634.1 - 1.2 8.9 5.9 0.13 12.0 0.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4200 PF13863.1 CDF88634.1 - 1.3 8.9 13.0 0.29 11.0 1.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Tropomyosin_1 PF12718.2 CDF88634.1 - 1.4 8.7 10.9 0.086 12.6 1.6 2.1 2 0 0 2 2 2 0 Tropomyosin like NPV_P10 PF05531.7 CDF88634.1 - 1.6 8.9 6.1 0.54 10.5 1.4 2.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein bZIP_2 PF07716.10 CDF88634.1 - 2.1 8.2 6.5 0.53 10.1 0.5 2.5 2 1 0 2 2 2 0 Basic region leucine zipper BLOC1_2 PF10046.4 CDF88634.1 - 2.5 8.2 12.2 0.23 11.5 1.8 2.1 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SlyX PF04102.7 CDF88634.1 - 2.9 8.3 9.3 0.11 12.8 1.5 2.1 2 1 0 2 2 2 0 SlyX DUF4140 PF13600.1 CDF88634.1 - 2.9 8.3 7.4 0.86 10.0 1.2 2.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Nsp1_C PF05064.8 CDF88634.1 - 3.2 7.4 11.3 0.079 12.6 1.9 2.1 2 1 0 2 2 2 0 Nsp1-like C-terminal region DUF972 PF06156.8 CDF88634.1 - 4.1 7.7 6.8 1 9.7 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF972) Med4 PF10018.4 CDF88634.1 - 6.2 6.1 8.8 0.48 9.7 0.8 2.1 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Fib_alpha PF08702.5 CDF88634.1 - 6.5 6.8 10.6 43 4.2 7.1 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Inhibitor_I9 PF05922.11 CDF88635.1 - 0.00039 20.9 0.3 0.0023 18.4 0.2 2.0 1 1 0 1 1 1 1 Peptidase inhibitor I9 DUF3053 PF11254.3 CDF88635.1 - 0.087 12.0 0.0 0.098 11.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3053) DUF3922 PF13059.1 CDF88635.1 - 0.11 12.6 0.2 2.8 8.1 0.0 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3992) Ammonium_transp PF00909.16 CDF88636.1 - 8.7e-126 419.5 30.0 1e-125 419.3 20.8 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF3185 PF11381.3 CDF88636.1 - 1.3 8.7 14.9 1.3 8.7 0.2 4.8 4 0 0 4 4 4 0 Protein of unknown function (DUF3185) Asparaginase PF00710.15 CDF88637.1 - 1.9e-17 63.1 2.5 3.1e-17 62.4 1.7 1.3 1 0 0 1 1 1 1 Asparaginase Far-17a_AIG1 PF04750.9 CDF88638.1 - 4.3e-18 65.2 3.6 1.4e-17 63.5 2.5 1.6 1 1 0 1 1 1 1 FAR-17a/AIG1-like protein MscS_TM PF12794.2 CDF88638.1 - 0.23 10.0 2.9 0.63 8.5 0.5 2.2 1 1 2 3 3 3 0 Mechanosensitive ion channel inner membrane domain 1 Pkinase PF00069.20 CDF88639.1 - 1.7e-55 187.9 9.7 1.6e-39 135.6 0.1 3.1 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDF88639.1 - 3.3e-24 85.3 10.3 3.1e-20 72.3 0.0 3.2 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase_C PF00433.19 CDF88639.1 - 0.0027 18.1 0.1 0.011 16.2 0.1 2.2 1 0 0 1 1 1 1 Protein kinase C terminal domain Seadorna_VP7 PF07387.6 CDF88639.1 - 0.058 12.2 0.0 0.09 11.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pox_ser-thr_kin PF05445.6 CDF88639.1 - 0.079 11.7 0.1 0.15 10.8 0.1 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Ribosomal_L44 PF00935.14 CDF88640.1 - 1.7e-33 114.4 11.1 2.5e-33 113.9 7.7 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 Chs3p PF12271.3 CDF88641.1 - 1.2e-97 326.4 17.0 2.6e-97 325.3 11.8 1.5 1 1 0 1 1 1 1 Chitin synthase III catalytic subunit DUF2583 PF10762.4 CDF88641.1 - 1.2 9.2 9.7 1.7 8.8 1.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2583) Zn-ribbon_8 PF09723.5 CDF88642.1 - 0.0078 16.1 1.5 0.048 13.6 0.2 2.3 2 1 0 2 2 2 1 Zinc ribbon domain zf-IS66 PF13005.2 CDF88642.1 - 0.043 13.7 1.2 0.087 12.8 0.8 1.5 1 0 0 1 1 1 0 zinc-finger binding domain of transposase IS66 IBR PF01485.16 CDF88642.1 - 0.24 11.3 2.2 2.7 7.9 1.5 2.0 1 1 0 1 1 1 0 IBR domain UPF0547 PF10571.4 CDF88642.1 - 0.52 10.0 5.2 2 8.1 3.6 2.0 1 1 0 1 1 1 0 Uncharacterised protein family UPF0547 zf-C2H2 PF00096.21 CDF88642.1 - 0.75 10.2 2.5 30 5.2 0.0 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type A2L_zn_ribbon PF08792.5 CDF88642.1 - 5.9 6.4 6.9 95 2.6 4.8 2.4 1 1 0 1 1 1 0 A2L zinc ribbon domain GTP_EFTU PF00009.22 CDF88643.1 - 3.1e-52 176.7 0.0 4.5e-52 176.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.19 CDF88643.1 - 2.2e-14 53.0 0.0 6.7e-14 51.5 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 CDF88643.1 - 9.3e-09 35.2 0.1 3.1e-08 33.6 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_II PF14492.1 CDF88643.1 - 2.3e-08 33.7 0.0 9e-08 31.8 0.0 2.0 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.13 CDF88643.1 - 1.9e-05 24.1 0.0 0.0001 21.8 0.0 2.2 2 0 0 2 2 2 1 Elongation factor G, domain IV MMR_HSR1 PF01926.18 CDF88643.1 - 0.0026 17.7 0.0 0.0058 16.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF904 PF06005.7 CDF88646.1 - 0.026 14.8 0.9 0.16 12.2 0.6 2.5 1 0 0 1 1 1 0 Protein of unknown function (DUF904) Pex26 PF07163.7 CDF88646.1 - 0.057 12.3 1.3 0.099 11.5 0.9 1.3 1 0 0 1 1 1 0 Pex26 protein DNA_RNApol_7kD PF03604.8 CDF88647.1 - 1.9e-16 59.1 1.8 2.5e-16 58.8 1.3 1.2 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit DZR PF12773.2 CDF88647.1 - 0.0033 17.2 0.4 0.0042 16.8 0.3 1.3 1 0 0 1 1 1 1 Double zinc ribbon TFIIS_C PF01096.13 CDF88647.1 - 0.0043 16.6 0.5 2.9 7.6 0.1 2.3 2 0 0 2 2 2 2 Transcription factor S-II (TFIIS) HypA PF01155.14 CDF88647.1 - 0.0049 16.5 0.2 0.0051 16.4 0.1 1.1 1 0 0 1 1 1 1 Hydrogenase expression/synthesis hypA family Prok-RING_1 PF14446.1 CDF88647.1 - 0.0068 16.1 0.6 0.0088 15.7 0.4 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 FYDLN_acid PF09538.5 CDF88647.1 - 0.028 14.9 0.3 0.034 14.7 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) NCD3G PF07562.9 CDF88647.1 - 0.031 14.0 0.2 0.037 13.7 0.1 1.2 1 0 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR C1_1 PF00130.17 CDF88647.1 - 0.058 13.1 0.3 0.08 12.6 0.2 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) A2L_zn_ribbon PF08792.5 CDF88647.1 - 0.061 12.7 0.9 0.94 9.0 0.0 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain DUF2318 PF10080.4 CDF88647.1 - 0.062 13.0 0.1 0.069 12.9 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) DUF951 PF06107.6 CDF88647.1 - 0.065 12.7 1.5 1.5 8.3 0.3 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF951) DUF4428 PF14471.1 CDF88647.1 - 0.066 12.9 1.5 2.1 8.1 1.1 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4428) FYVE_2 PF02318.11 CDF88647.1 - 0.078 12.8 0.3 0.088 12.7 0.2 1.1 1 0 0 1 1 1 0 FYVE-type zinc finger DUF2197 PF09963.4 CDF88647.1 - 0.087 12.7 2.4 7.5 6.6 0.2 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) Herpes_UL33 PF03581.8 CDF88647.1 - 0.15 11.9 0.1 0.18 11.7 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus UL33-like protein Zn_ribbon_recom PF13408.1 CDF88647.1 - 0.21 11.8 3.2 3.4 8.0 0.5 2.1 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain Ribosomal_L40e PF01020.12 CDF88647.1 - 0.36 10.4 3.0 0.48 10.0 2.1 1.2 1 0 0 1 1 1 0 Ribosomal L40e family Zn-ribbon_8 PF09723.5 CDF88647.1 - 0.36 10.8 3.4 1.2 9.2 2.3 1.8 1 1 0 1 1 1 0 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.2 CDF88647.1 - 0.5 10.2 3.1 2.2 8.1 2.4 1.7 1 1 1 2 2 2 0 Transposase zinc-ribbon domain TF_Zn_Ribbon PF08271.7 CDF88647.1 - 0.63 9.4 2.6 8.1 5.8 2.1 2.0 1 1 1 2 2 2 0 TFIIB zinc-binding zinc_ribbon_4 PF13717.1 CDF88647.1 - 1.1 9.0 3.5 8.8 6.1 2.4 2.3 1 1 1 2 2 2 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 CDF88647.1 - 1.2 8.8 3.7 8.2 6.1 2.5 2.3 1 1 1 2 2 2 0 zinc-ribbon domain Ribosomal_L44 PF00935.14 CDF88647.1 - 1.9 8.5 4.6 11 6.0 0.5 2.1 1 1 1 2 2 2 0 Ribosomal protein L44 bZIP_1 PF00170.16 CDF88648.1 - 4.1e-07 29.8 2.5 4.1e-07 29.8 1.7 1.9 2 0 0 2 2 2 1 bZIP transcription factor Aft1_OSA PF11785.3 CDF88648.1 - 1.7e-05 25.2 3.9 1.7e-05 25.2 2.7 5.1 3 1 1 4 4 4 1 Aft1 osmotic stress response (OSM) domain bZIP_2 PF07716.10 CDF88648.1 - 0.002 17.9 7.1 0.0063 16.3 4.9 1.9 1 0 0 1 1 1 1 Basic region leucine zipper PRTP PF01366.13 CDF88648.1 - 8.5 4.2 8.4 15 3.4 5.8 1.3 1 0 0 1 1 1 0 Herpesvirus processing and transport protein FAA_hydrolase PF01557.13 CDF88649.1 - 2.3e-48 164.5 0.0 3.1e-48 164.1 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family dCMP_cyt_deam_1 PF00383.17 CDF88650.1 - 9.6e-26 89.4 3.4 1.6e-25 88.6 2.3 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region PS_Dcarbxylase PF02666.10 CDF88651.1 - 4.1e-72 241.7 0.0 6.3e-72 241.1 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Apc1 PF12859.2 CDF88652.1 - 4.4e-15 55.8 3.8 3.4e-14 52.9 2.7 2.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.17 CDF88652.1 - 0.054 13.7 6.6 3 8.2 0.8 5.2 6 0 0 6 6 6 0 Proteasome/cyclosome repeat RRM_1 PF00076.17 CDF88654.1 - 2.8e-30 103.7 2.8 8.2e-19 67.0 0.0 3.8 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF88654.1 - 7.6e-27 93.0 0.2 3.2e-14 52.6 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF88654.1 - 2.3e-14 52.9 0.2 1.6e-08 34.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CDF88654.1 - 0.00099 18.8 0.0 0.0061 16.2 0.0 2.1 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Ctf8 PF09696.5 CDF88654.1 - 0.0028 17.4 0.2 0.013 15.2 0.1 2.1 2 0 0 2 2 2 1 Ctf8 DUP PF00674.13 CDF88657.1 - 1.4e-09 37.8 0.1 1.6e-09 37.6 0.1 1.1 1 0 0 1 1 1 1 DUP family DUP PF00674.13 CDF88658.1 - 8.2e-12 45.0 0.6 1.5e-11 44.2 0.4 1.3 1 0 0 1 1 1 1 DUP family Gsf2 PF11055.3 CDF88659.1 - 6.7e-155 515.2 0.0 8.9e-155 514.8 0.0 1.1 1 0 0 1 1 1 1 Glucose signalling factor 2 Syntaxin_2 PF14523.1 CDF88659.1 - 0.18 11.8 4.5 0.68 9.9 3.1 1.9 1 1 0 1 1 1 0 Syntaxin-like protein CPSF_A PF03178.10 CDF88660.1 - 6e-58 196.4 1.0 1.8e-57 194.8 0.5 1.9 2 0 0 2 2 2 1 CPSF A subunit region MMS1_N PF10433.4 CDF88660.1 - 4.8e-28 97.5 0.5 9.2e-28 96.6 0.3 1.4 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term BBS2_N PF14781.1 CDF88660.1 - 0.14 11.7 2.1 3.8 7.1 0.0 3.4 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, N-terminal Suc_Fer-like PF06999.7 CDF88661.1 - 1.2e-37 130.1 0.0 1.5e-37 129.8 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like SNN_linker PF09050.5 CDF88661.1 - 0.14 11.7 0.0 0.28 10.7 0.0 1.5 1 0 0 1 1 1 0 Stannin unstructured linker zf-HIT PF04438.11 CDF88662.1 - 2e-12 46.5 10.6 2e-12 46.5 7.4 1.7 2 0 0 2 2 2 1 HIT zinc finger DUF1610 PF07754.6 CDF88662.1 - 0.016 15.2 3.8 0.21 11.7 2.7 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1610) zf-MYND PF01753.13 CDF88662.1 - 0.023 14.5 9.3 0.042 13.7 6.4 1.4 1 0 0 1 1 1 0 MYND finger YL1_C PF08265.6 CDF88662.1 - 0.08 12.5 0.0 0.21 11.1 0.0 1.6 1 0 0 1 1 1 0 YL1 nuclear protein C-terminal domain zf-Mss51 PF13824.1 CDF88662.1 - 0.09 12.6 5.6 0.19 11.6 3.9 1.6 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-B_box PF00643.19 CDF88662.1 - 5.6 6.9 10.8 0.64 9.9 4.3 1.8 2 0 0 2 2 2 0 B-box zinc finger GFO_IDH_MocA PF01408.17 CDF88663.1 - 7.7e-06 26.4 0.0 1.2e-05 25.8 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 CDF88663.1 - 0.07 12.9 0.0 0.18 11.6 0.0 1.7 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain SUR7 PF06687.7 CDF88664.1 - 7.6e-31 107.3 5.6 1e-30 106.8 3.9 1.1 1 0 0 1 1 1 1 SUR7/PalI family WTF PF03303.8 CDF88664.1 - 0.02 14.2 0.4 0.045 13.1 0.3 1.6 1 0 0 1 1 1 0 WTF protein DUF2207 PF09972.4 CDF88664.1 - 0.14 10.6 1.7 0.24 9.9 1.2 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF1440 PF07274.7 CDF88664.1 - 2.3 8.2 6.1 22 5.0 4.2 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1440) DUF4588 PF15251.1 CDF88665.1 - 7.1e-07 29.4 8.7 5.3e-05 23.3 0.0 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF4588) Thymidylate_kin PF02223.12 CDF88667.1 - 1.1e-39 135.7 0.0 1.3e-39 135.4 0.0 1.1 1 0 0 1 1 1 1 Thymidylate kinase AAA_18 PF13238.1 CDF88667.1 - 0.0098 16.2 0.0 0.019 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 CDF88667.1 - 0.088 12.7 0.1 0.17 11.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain Clat_adaptor_s PF01217.15 CDF88668.1 - 5.6e-54 181.7 2.8 6.3e-54 181.5 1.9 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain AAA PF00004.24 CDF88669.1 - 2.5e-54 183.0 0.0 2.9e-44 150.4 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.6 CDF88669.1 - 7.3e-24 83.6 0.5 2e-23 82.2 0.2 2.0 2 0 0 2 2 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_16 PF13191.1 CDF88669.1 - 1.2e-10 41.7 0.1 0.00014 21.9 0.0 3.4 2 1 0 3 3 3 2 AAA ATPase domain AAA_14 PF13173.1 CDF88669.1 - 9.7e-08 31.9 0.0 0.014 15.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 CDF88669.1 - 1e-07 31.7 0.6 0.0069 16.0 0.0 3.6 3 0 0 3 3 3 2 NACHT domain AAA_17 PF13207.1 CDF88669.1 - 4.1e-07 30.8 0.0 0.05 14.4 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 CDF88669.1 - 4.6e-07 30.0 2.3 0.045 13.8 0.0 3.7 3 2 0 3 3 3 2 AAA domain AAA_33 PF13671.1 CDF88669.1 - 8.4e-07 28.9 0.0 0.0087 15.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.9 CDF88669.1 - 8.6e-07 28.7 0.1 0.076 12.7 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 CDF88669.1 - 1.6e-06 27.3 0.1 0.0018 17.3 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_28 PF13521.1 CDF88669.1 - 2.2e-06 27.7 0.0 0.08 12.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 CDF88669.1 - 5.1e-06 26.8 0.1 0.11 12.7 0.1 3.2 2 1 0 2 2 2 2 AAA domain NB-ARC PF00931.17 CDF88669.1 - 1.5e-05 24.0 0.1 0.022 13.6 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain IstB_IS21 PF01695.12 CDF88669.1 - 1.6e-05 24.4 0.0 0.22 10.8 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_19 PF13245.1 CDF88669.1 - 3.1e-05 23.6 0.1 0.051 13.3 0.0 2.5 2 0 0 2 2 2 2 Part of AAA domain Arch_ATPase PF01637.13 CDF88669.1 - 0.00012 21.8 0.0 0.39 10.3 0.0 3.4 2 1 1 3 3 3 1 Archaeal ATPase AAA_3 PF07726.6 CDF88669.1 - 0.00018 21.1 0.0 0.13 11.8 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 CDF88669.1 - 0.00021 20.7 0.6 0.65 9.3 0.1 3.9 2 2 2 4 4 4 1 AAA domain Zeta_toxin PF06414.7 CDF88669.1 - 0.00037 19.6 0.0 0.16 11.0 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_2 PF07724.9 CDF88669.1 - 0.00046 20.1 0.0 0.0026 17.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.17 CDF88669.1 - 0.00063 19.8 0.1 0.82 9.8 0.0 3.4 3 0 0 3 3 2 1 RNA helicase Mg_chelatase PF01078.16 CDF88669.1 - 0.0011 18.1 0.2 0.13 11.3 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI ABC_tran PF00005.22 CDF88669.1 - 0.0014 18.9 0.1 3.6 7.8 0.0 3.5 2 1 1 3 3 3 1 ABC transporter Viral_helicase1 PF01443.13 CDF88669.1 - 0.0015 18.1 0.0 1.2 8.5 0.0 2.7 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.10 CDF88669.1 - 0.0018 18.0 0.3 0.2 11.3 0.0 2.4 2 0 0 2 2 2 1 NTPase Vps4_C PF09336.5 CDF88669.1 - 0.0031 17.3 0.0 0.0095 15.8 0.0 1.8 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_24 PF13479.1 CDF88669.1 - 0.0045 16.5 0.9 2.4 7.7 0.1 2.5 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 CDF88669.1 - 0.0057 15.5 0.0 0.15 10.9 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein TIP49 PF06068.8 CDF88669.1 - 0.0062 15.3 0.6 0.034 12.8 0.0 2.5 3 0 0 3 3 3 1 TIP49 C-terminus Cytidylate_kin2 PF13189.1 CDF88669.1 - 0.018 14.9 0.0 0.053 13.4 0.0 1.8 1 0 0 1 1 1 0 Cytidylate kinase-like family Bac_DnaA PF00308.13 CDF88669.1 - 0.019 14.6 0.0 1.6 8.3 0.0 2.6 2 0 0 2 2 2 0 Bacterial dnaA protein AAA_10 PF12846.2 CDF88669.1 - 0.023 14.1 0.8 0.47 9.8 0.0 2.9 3 0 0 3 3 3 0 AAA-like domain UPF0079 PF02367.12 CDF88669.1 - 0.025 14.2 0.2 5.7 6.5 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 cobW PF02492.14 CDF88669.1 - 0.029 13.8 1.1 2.5 7.4 0.0 2.7 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain DUF2075 PF09848.4 CDF88669.1 - 0.031 13.2 0.6 8.5 5.2 0.0 3.0 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) SKI PF01202.17 CDF88669.1 - 0.036 13.9 0.0 1.3 8.8 0.0 2.9 3 0 0 3 3 2 0 Shikimate kinase Pkinase PF00069.20 CDF88670.1 - 1.8e-40 138.7 0.0 2.5e-40 138.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF88670.1 - 3e-15 56.0 0.0 4.8e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF88670.1 - 0.0012 17.8 0.0 0.002 17.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 CDF88670.1 - 0.012 14.6 0.0 0.022 13.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Rrn6 PF10214.4 CDF88670.1 - 0.25 9.3 4.1 0.32 9.0 2.8 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor HLH PF00010.21 CDF88671.1 - 1.6e-12 46.9 2.9 4.2e-12 45.5 2.0 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF4363 PF14276.1 CDF88671.1 - 0.024 14.3 2.1 0.037 13.7 0.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4363) gpUL132 PF11359.3 CDF88671.1 - 0.16 11.3 0.9 0.35 10.1 0.6 1.6 1 0 0 1 1 1 0 Glycoprotein UL132 CorA PF01544.13 CDF88671.1 - 0.72 8.8 5.8 1.2 8.1 4.0 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF4558 PF15104.1 CDF88671.1 - 2.4 8.1 9.4 0.3 11.0 1.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4558) MRP-S31 PF15433.1 CDF88671.1 - 7 5.9 13.1 1.1 8.6 5.8 1.8 1 1 1 2 2 2 0 Mitochondrial 28S ribosomal protein S31 LicD PF04991.8 CDF88672.1 - 2e-44 152.1 3.7 2e-44 152.1 2.6 2.0 2 0 0 2 2 2 1 LicD family CN_hydrolase PF00795.17 CDF88673.1 - 1.8e-15 56.8 0.0 2.8e-15 56.1 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase CHASE4 PF05228.8 CDF88673.1 - 0.053 13.0 0.0 0.19 11.3 0.0 1.7 2 0 0 2 2 2 0 CHASE4 domain PRCC PF10253.4 CDF88674.1 - 1.5e-05 25.7 6.5 3.4e-05 24.6 4.6 1.4 1 1 0 1 1 1 1 Mitotic checkpoint regulator, MAD2B-interacting TFIIS_C PF01096.13 CDF88675.1 - 5.4e-20 70.7 1.3 5.4e-20 70.7 0.9 2.8 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.11 CDF88675.1 - 3.1e-14 52.3 9.8 1.6e-11 43.6 0.6 3.0 2 1 0 2 2 2 2 RNA polymerases M/15 Kd subunit zf-ribbon_3 PF13248.1 CDF88675.1 - 0.00011 21.2 8.7 1.2 8.4 0.2 4.2 4 0 0 4 4 4 2 zinc-ribbon domain Lar_restr_allev PF14354.1 CDF88675.1 - 0.00019 21.6 6.1 0.0017 18.6 0.3 2.7 2 1 0 2 2 2 1 Restriction alleviation protein Lar zinc_ribbon_2 PF13240.1 CDF88675.1 - 0.00043 19.6 13.1 0.45 10.0 0.2 4.2 4 0 0 4 4 4 2 zinc-ribbon domain Mu-like_Com PF10122.4 CDF88675.1 - 0.0013 17.7 1.1 0.17 10.9 0.1 2.8 2 1 0 2 2 2 1 Mu-like prophage protein Com DZR PF12773.2 CDF88675.1 - 0.0014 18.4 7.9 0.21 11.4 0.2 3.0 2 1 0 2 2 2 2 Double zinc ribbon zinc_ribbon_4 PF13717.1 CDF88675.1 - 0.0016 18.0 9.8 0.8 9.4 0.6 3.4 3 0 0 3 3 3 1 zinc-ribbon domain zinc_ribbon_5 PF13719.1 CDF88675.1 - 0.0035 16.8 10.6 0.79 9.3 0.5 3.4 3 0 0 3 3 3 1 zinc-ribbon domain TF_Zn_Ribbon PF08271.7 CDF88675.1 - 0.0068 15.7 14.2 0.021 14.1 2.9 2.8 2 2 0 2 2 2 2 TFIIB zinc-binding CpXC PF14353.1 CDF88675.1 - 0.007 16.3 4.2 0.41 10.5 0.0 3.1 2 1 1 3 3 3 1 CpXC protein Ogr_Delta PF04606.7 CDF88675.1 - 0.0072 15.9 7.6 0.02 14.5 2.6 2.6 2 1 0 2 2 2 1 Ogr/Delta-like zinc finger Zn_Tnp_IS1595 PF12760.2 CDF88675.1 - 0.0077 16.0 1.2 0.0077 16.0 0.8 2.5 2 2 0 2 2 2 1 Transposase zinc-ribbon domain zf-DNA_Pol PF08996.5 CDF88675.1 - 0.0089 15.3 2.8 0.12 11.7 0.2 2.1 2 0 0 2 2 2 1 DNA Polymerase alpha zinc finger zf-C4_Topoisom PF01396.14 CDF88675.1 - 0.015 14.7 3.2 0.015 14.7 2.2 3.0 3 1 0 3 3 2 0 Topoisomerase DNA binding C4 zinc finger C1_1 PF00130.17 CDF88675.1 - 0.022 14.5 3.2 0.74 9.5 0.1 2.5 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RRN7 PF11781.3 CDF88675.1 - 0.022 14.2 4.0 5.5 6.5 0.1 3.3 3 0 0 3 3 3 0 RNA polymerase I-specific transcription initiation factor Rrn7 zf-TFIIB PF13453.1 CDF88675.1 - 0.027 13.6 0.6 0.027 13.6 0.4 2.4 2 0 0 2 2 2 0 Transcription factor zinc-finger Elf1 PF05129.8 CDF88675.1 - 0.043 13.5 3.5 0.27 10.9 0.2 2.4 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like zf-C3HC4_3 PF13920.1 CDF88675.1 - 0.047 13.3 2.7 2.9 7.6 0.1 3.0 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Baculo_LEF5_C PF11792.3 CDF88675.1 - 0.058 12.7 1.0 0.058 12.7 0.7 2.7 2 1 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain DUF2387 PF09526.5 CDF88675.1 - 0.067 13.1 0.3 0.067 13.1 0.2 2.5 2 1 1 3 3 3 0 Probable metal-binding protein (DUF2387) zf-ISL3 PF14690.1 CDF88675.1 - 0.068 13.2 3.4 2.5 8.1 0.2 3.1 3 0 0 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 DUF3716 PF12511.3 CDF88675.1 - 0.069 12.7 2.0 0.4 10.3 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3716) Zn-ribbon_8 PF09723.5 CDF88675.1 - 0.078 12.9 13.1 4 7.4 0.6 3.4 3 0 0 3 3 3 0 Zinc ribbon domain Rubredoxin PF00301.15 CDF88675.1 - 0.11 12.3 4.9 13 5.7 0.2 3.3 3 0 0 3 3 3 0 Rubredoxin Terminase_GpA PF05876.7 CDF88675.1 - 0.12 10.7 0.4 0.33 9.2 0.2 1.7 2 0 0 2 2 2 0 Phage terminase large subunit (GpA) Stc1 PF12898.2 CDF88675.1 - 0.13 12.3 0.5 0.13 12.3 0.3 2.3 1 1 0 2 2 2 0 Stc1 domain zf-H2C2_2 PF13465.1 CDF88675.1 - 0.13 12.5 8.3 0.64 10.4 0.5 3.3 3 0 0 3 3 3 0 Zinc-finger double domain Ribosomal_S27e PF01667.12 CDF88675.1 - 0.22 11.1 5.6 12 5.5 0.0 3.8 3 1 1 4 4 4 0 Ribosomal protein S27 PolC_DP2 PF03833.8 CDF88675.1 - 0.34 8.5 3.5 0.17 9.5 0.5 1.7 1 1 1 2 2 2 0 DNA polymerase II large subunit DP2 Nop10p PF04135.7 CDF88675.1 - 0.39 10.4 2.3 0.78 9.5 0.2 2.5 1 1 2 3 3 2 0 Nucleolar RNA-binding protein, Nop10p family DUF2072 PF09845.4 CDF88675.1 - 0.41 10.5 0.1 0.41 10.5 0.1 2.9 1 1 1 3 3 3 0 Zn-ribbon containing protein (DUF2072) OrfB_Zn_ribbon PF07282.6 CDF88675.1 - 0.5 10.0 7.6 6.7 6.4 1.7 2.7 2 1 0 2 2 2 0 Putative transposase DNA-binding domain zf-C3HC4_4 PF15227.1 CDF88675.1 - 0.55 10.1 6.1 0.57 10.0 0.4 3.0 3 1 0 3 3 3 0 zinc finger of C3HC4-type, RING HypA PF01155.14 CDF88675.1 - 0.72 9.5 8.4 2.3 7.9 1.6 3.0 1 1 2 3 3 3 0 Hydrogenase expression/synthesis hypA family zf-AN1 PF01428.11 CDF88675.1 - 0.78 9.6 10.1 9.3 6.2 0.5 3.5 3 1 0 3 3 3 0 AN1-like Zinc finger Zn_Tnp_IS1 PF03811.8 CDF88675.1 - 1.5 8.4 3.9 5.8 6.5 0.0 2.8 3 0 0 3 3 3 0 InsA N-terminal domain zf-C2H2_4 PF13894.1 CDF88675.1 - 1.7 9.1 8.2 44 4.7 1.2 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger NOB1_Zn_bind PF08772.6 CDF88675.1 - 7.4 6.4 9.6 1.1 9.1 0.8 3.0 2 2 0 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like GATA PF00320.22 CDF88675.1 - 7.4 6.0 8.3 2.1 7.7 1.0 2.8 3 0 0 3 3 3 0 GATA zinc finger zf-CHY PF05495.7 CDF88675.1 - 7.7 6.7 7.8 9.4 6.4 0.1 2.9 2 1 1 3 3 3 0 CHY zinc finger zf-IS66 PF13005.2 CDF88675.1 - 8.8 6.3 7.5 18 5.3 0.1 3.5 4 0 0 4 4 4 0 zinc-finger binding domain of transposase IS66 XPA_N PF01286.13 CDF88675.1 - 9.8 5.9 12.4 7.8 6.2 0.2 3.8 4 0 0 4 4 4 0 XPA protein N-terminal Cpn60_TCP1 PF00118.19 CDF88676.1 - 7.2e-145 483.3 3.6 8.3e-145 483.1 2.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Resolvase PF00239.16 CDF88676.1 - 0.011 15.5 0.2 0.69 9.7 0.0 2.5 2 0 0 2 2 2 0 Resolvase, N terminal domain AP_endonuc_2 PF01261.19 CDF88676.1 - 0.11 11.7 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Actin PF00022.14 CDF88677.1 - 8.2e-92 307.6 0.0 2.2e-91 306.1 0.0 1.6 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.8 CDF88677.1 - 1.3e-06 27.3 0.0 0.0014 17.2 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FAT PF02259.18 CDF88678.1 - 3.1e-138 460.5 0.0 3.1e-138 460.5 0.0 2.3 3 0 0 3 3 3 1 FAT domain DUF3385 PF11865.3 CDF88678.1 - 3.3e-65 218.8 0.4 3.3e-65 218.8 0.3 4.6 5 1 0 5 5 5 1 Domain of unknown function (DUF3385) PI3_PI4_kinase PF00454.22 CDF88678.1 - 3.5e-61 206.6 0.1 6.7e-61 205.7 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Rapamycin_bind PF08771.6 CDF88678.1 - 4.8e-42 142.1 0.5 4.8e-42 142.1 0.3 3.2 3 0 0 3 3 3 1 Rapamycin binding domain FATC PF02260.15 CDF88678.1 - 2.4e-19 68.4 0.3 6.3e-19 67.1 0.2 1.8 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.1 CDF88678.1 - 4.4e-14 52.5 8.0 0.23 11.7 0.0 8.9 6 2 2 8 8 8 4 HEAT repeats HEAT_EZ PF13513.1 CDF88678.1 - 1.8e-10 40.9 6.3 4.2e-05 23.9 0.0 8.7 9 1 1 10 10 10 2 HEAT-like repeat HEAT PF02985.17 CDF88678.1 - 7.7e-08 31.7 6.7 0.051 13.6 0.0 7.9 8 0 0 8 8 8 2 HEAT repeat DUF3437 PF11919.3 CDF88678.1 - 0.03 14.0 0.0 1.6 8.5 0.0 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) Vac14_Fab1_bd PF12755.2 CDF88678.1 - 0.095 13.0 5.4 8.4 6.8 0.0 5.3 5 1 0 5 5 5 0 Vacuolar 14 Fab1-binding region Yae1_N PF09811.4 CDF88679.1 - 2e-11 43.1 0.1 4e-11 42.2 0.1 1.5 1 0 0 1 1 1 1 Essential protein Yae1, N terminal AAA PF00004.24 CDF88680.1 - 9.4e-16 58.2 0.0 3.2e-15 56.5 0.0 1.8 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.6 CDF88680.1 - 8.1e-14 51.3 0.0 2e-13 50.0 0.0 1.7 2 0 0 2 2 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 CDF88680.1 - 2.9e-13 49.8 0.0 8.5e-13 48.2 0.0 1.8 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.10 CDF88680.1 - 8.9e-12 44.4 0.0 7.3e-08 31.5 0.0 2.3 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_22 PF13401.1 CDF88680.1 - 7.3e-07 29.3 0.1 6.8e-06 26.2 0.0 2.5 2 2 0 2 2 2 1 AAA domain RuvB_N PF05496.7 CDF88680.1 - 3.9e-06 26.0 0.1 1.6e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_11 PF13086.1 CDF88680.1 - 1.4e-05 24.7 0.0 2.3e-05 24.0 0.0 1.3 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 CDF88680.1 - 2.2e-05 23.7 0.0 0.0014 17.7 0.0 2.7 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.1 CDF88680.1 - 2.3e-05 24.4 0.3 0.00037 20.5 0.0 2.5 2 1 0 3 3 3 1 AAA ATPase domain AAA_19 PF13245.1 CDF88680.1 - 8.4e-05 22.2 0.0 0.00018 21.1 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_14 PF13173.1 CDF88680.1 - 0.00058 19.7 0.0 0.0016 18.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 CDF88680.1 - 0.0011 18.6 0.2 0.0032 17.0 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.1 CDF88680.1 - 0.0017 17.9 0.0 0.005 16.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain DNA_pol3_gamma3 PF12169.3 CDF88680.1 - 0.0022 17.7 0.3 0.011 15.4 0.0 2.3 3 0 0 3 3 3 1 DNA polymerase III subunits gamma and tau domain III CLTH PF10607.4 CDF88680.1 - 0.0025 17.5 0.1 0.0056 16.3 0.1 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain DUF815 PF05673.8 CDF88680.1 - 0.0041 16.0 0.0 0.007 15.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_17 PF13207.1 CDF88680.1 - 0.0042 17.8 0.0 0.017 15.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain ResIII PF04851.10 CDF88680.1 - 0.005 16.6 0.0 0.027 14.2 0.0 2.1 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 CDF88680.1 - 0.014 14.2 0.0 0.24 10.1 0.0 2.1 1 1 0 2 2 2 0 SNF2 family N-terminal domain Arch_ATPase PF01637.13 CDF88680.1 - 0.014 15.0 0.1 0.088 12.4 0.0 2.2 1 1 1 2 2 2 0 Archaeal ATPase AAA_23 PF13476.1 CDF88680.1 - 0.016 15.5 0.0 0.028 14.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.9 CDF88680.1 - 0.022 14.4 0.1 0.21 11.3 0.1 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 CDF88680.1 - 0.046 13.1 0.2 0.21 10.9 0.1 2.2 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.1 CDF88680.1 - 0.049 13.9 0.0 0.25 11.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.4 CDF88680.1 - 0.054 12.4 0.0 0.099 11.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_10 PF12846.2 CDF88680.1 - 0.058 12.8 0.1 0.32 10.4 0.1 2.4 1 1 0 1 1 1 0 AAA-like domain TIP49 PF06068.8 CDF88680.1 - 0.058 12.1 0.0 0.72 8.5 0.0 2.1 2 0 0 2 2 2 0 TIP49 C-terminus FtsK_SpoIIIE PF01580.13 CDF88680.1 - 0.08 12.4 0.1 0.35 10.3 0.0 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_28 PF13521.1 CDF88680.1 - 0.091 12.7 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.6 CDF88680.1 - 0.099 12.2 0.0 1 8.9 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Xpo1 PF08389.7 CDF88682.1 - 1.6e-35 122.2 1.2 1.6e-35 122.2 0.8 3.8 5 0 0 5 5 5 1 Exportin 1-like protein ATP-gua_PtransN PF02807.10 CDF88682.1 - 0.00075 19.6 0.1 0.0057 16.7 0.0 2.5 3 0 0 3 3 3 1 ATP:guanido phosphotransferase, N-terminal domain Ham1p_like PF01725.11 CDF88683.1 - 6.4e-51 172.4 0.0 7.1e-51 172.2 0.0 1.0 1 0 0 1 1 1 1 Ham1 family HEAT_2 PF13646.1 CDF88684.1 - 5.2e-32 109.9 0.2 2.1e-15 56.7 0.0 3.0 2 1 1 3 3 3 2 HEAT repeats HEAT_PBS PF03130.11 CDF88684.1 - 1.1e-19 68.8 0.0 0.00021 21.4 0.0 6.1 6 0 0 6 6 6 4 PBS lyase HEAT-like repeat HEAT PF02985.17 CDF88684.1 - 1.1e-09 37.5 1.6 0.2 11.8 0.1 5.8 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.1 CDF88684.1 - 2e-07 31.2 2.6 0.025 15.0 0.1 4.6 2 2 3 5 5 5 4 HEAT-like repeat Arm PF00514.18 CDF88684.1 - 0.0004 20.1 0.2 0.18 11.6 0.0 3.2 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat PAC2 PF09754.4 CDF88685.1 - 1.1e-31 110.4 0.0 1.3e-31 110.1 0.0 1.1 1 0 0 1 1 1 1 PAC2 family ATP_bind_1 PF03029.12 CDF88686.1 - 2.1e-83 279.4 0.0 3.1e-83 278.9 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.22 CDF88686.1 - 6.6e-06 25.6 0.1 0.00013 21.5 0.1 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain CbiA PF01656.18 CDF88686.1 - 1e-05 25.0 0.0 2.5e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_17 PF13207.1 CDF88686.1 - 0.00011 23.0 0.1 0.0016 19.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 CDF88686.1 - 0.00029 20.7 0.0 0.00082 19.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_10 PF12846.2 CDF88686.1 - 0.00047 19.6 0.2 0.0056 16.1 0.1 2.2 1 1 0 1 1 1 1 AAA-like domain MMR_HSR1 PF01926.18 CDF88686.1 - 0.00098 19.0 0.1 0.0037 17.2 0.0 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.1 CDF88686.1 - 0.0014 18.7 0.0 0.0062 16.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 CDF88686.1 - 0.0019 17.9 0.0 0.0037 16.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain DUF258 PF03193.11 CDF88686.1 - 0.0023 17.1 0.1 0.27 10.3 0.0 3.1 2 1 0 2 2 2 1 Protein of unknown function, DUF258 FeoB_N PF02421.13 CDF88686.1 - 0.0028 16.9 0.0 0.074 12.3 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_24 PF13479.1 CDF88686.1 - 0.0028 17.2 0.0 0.0067 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.4 CDF88686.1 - 0.003 17.0 0.1 0.048 13.1 0.0 2.7 3 0 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation Miro PF08477.8 CDF88686.1 - 0.0034 17.8 0.3 0.22 11.9 0.0 2.7 2 1 0 2 2 1 1 Miro-like protein SRP54 PF00448.17 CDF88686.1 - 0.0038 16.6 0.0 0.039 13.4 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_16 PF13191.1 CDF88686.1 - 0.0075 16.2 0.0 0.021 14.8 0.0 1.7 2 0 0 2 2 1 1 AAA ATPase domain cobW PF02492.14 CDF88686.1 - 0.0085 15.5 0.1 0.16 11.4 0.1 2.5 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ArgK PF03308.11 CDF88686.1 - 0.016 13.9 0.0 0.15 10.8 0.0 2.2 2 1 0 2 2 2 0 ArgK protein SRPRB PF09439.5 CDF88686.1 - 0.021 14.0 0.1 0.4 9.8 0.0 2.3 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit MobB PF03205.9 CDF88686.1 - 0.032 13.9 0.2 0.15 11.7 0.0 2.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.1 CDF88686.1 - 0.035 14.4 1.2 0.095 13.0 0.0 2.3 2 1 0 2 2 2 0 AAA domain Med2 PF11214.3 CDF88686.1 - 0.035 14.1 0.9 0.081 12.9 0.2 1.9 2 0 0 2 2 2 0 Mediator complex subunit 2 UPF0079 PF02367.12 CDF88686.1 - 0.037 13.6 0.0 0.076 12.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Glyco_tranf_2_3 PF13641.1 CDF88686.1 - 0.047 13.4 0.0 0.079 12.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 KTI12 PF08433.5 CDF88686.1 - 0.049 12.8 0.0 0.094 11.9 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Septin PF00735.13 CDF88686.1 - 0.06 12.3 0.1 0.27 10.2 0.0 2.0 1 1 0 1 1 1 0 Septin Arf PF00025.16 CDF88686.1 - 0.092 11.9 0.0 0.68 9.1 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family G-alpha PF00503.15 CDF88686.1 - 0.48 9.0 5.8 2.7 6.5 0.0 3.0 3 1 0 4 4 4 0 G-protein alpha subunit DUF106 PF01956.11 CDF88687.1 - 4.5e-54 182.4 1.1 5.4e-54 182.2 0.8 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF106 Glyphos_transf PF04464.9 CDF88688.1 - 0.01 14.6 0.4 0.017 13.8 0.3 1.2 1 0 0 1 1 1 0 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase Tn7_Tnp_TnsA_C PF08721.6 CDF88688.1 - 0.018 15.0 0.8 0.094 12.7 0.2 2.2 2 0 0 2 2 2 0 TnsA endonuclease C terminal PEMT PF04191.8 CDF88689.1 - 1.9e-34 117.9 2.9 4.1e-34 116.8 2.0 1.5 1 0 0 1 1 1 1 Phospholipid methyltransferase Steroid_dh PF02544.11 CDF88689.1 - 0.028 14.1 1.1 0.028 14.1 0.7 1.9 2 1 0 2 2 2 0 3-oxo-5-alpha-steroid 4-dehydrogenase ABC_membrane PF00664.18 CDF88690.1 - 1.2e-75 254.5 35.7 3.7e-38 131.5 10.3 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 CDF88690.1 - 1.8e-59 199.9 0.0 6.1e-31 107.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_10 PF12846.2 CDF88690.1 - 2.5e-10 40.2 0.1 0.0039 16.6 0.1 4.2 4 0 0 4 4 4 2 AAA-like domain SMC_N PF02463.14 CDF88690.1 - 3.5e-10 39.5 7.9 0.011 14.9 0.0 4.7 4 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain DUF258 PF03193.11 CDF88690.1 - 1.1e-08 34.4 0.0 0.0035 16.5 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 ABC_ATPase PF09818.4 CDF88690.1 - 8.6e-08 31.1 0.0 0.0019 16.8 0.0 3.1 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_29 PF13555.1 CDF88690.1 - 1.3e-07 31.0 1.6 0.0084 15.6 0.1 3.1 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_21 PF13304.1 CDF88690.1 - 1.3e-07 31.8 9.6 0.021 14.7 0.3 4.5 2 2 0 2 2 2 2 AAA domain AAA_17 PF13207.1 CDF88690.1 - 1.4e-07 32.3 0.0 0.0089 16.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 CDF88690.1 - 2.2e-07 31.0 0.7 0.093 12.8 0.1 3.9 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.1 CDF88690.1 - 2.8e-07 30.7 0.1 0.032 14.2 0.0 2.6 2 1 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.18 CDF88690.1 - 5.4e-07 29.5 0.1 0.0051 16.7 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase Miro PF08477.8 CDF88690.1 - 2.7e-05 24.6 0.0 0.17 12.4 0.0 2.8 2 0 0 2 2 2 2 Miro-like protein AAA_18 PF13238.1 CDF88690.1 - 8.1e-05 22.9 0.0 0.55 10.5 0.0 3.0 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 CDF88690.1 - 0.00013 22.0 0.0 0.42 10.8 0.0 3.0 2 0 0 2 2 2 2 RNA helicase AAA_5 PF07728.9 CDF88690.1 - 0.00017 21.3 0.0 2.1 8.0 0.0 3.8 4 0 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 CDF88690.1 - 0.00024 21.0 0.1 0.38 10.6 0.0 3.5 3 0 0 3 3 3 1 AAA domain DUF87 PF01935.12 CDF88690.1 - 0.00033 20.5 0.1 0.98 9.1 0.0 2.9 2 0 0 2 2 2 2 Domain of unknown function DUF87 Dynamin_N PF00350.18 CDF88690.1 - 0.00053 19.8 1.0 1.2 8.9 0.1 2.7 2 0 0 2 2 2 2 Dynamin family MobB PF03205.9 CDF88690.1 - 0.00069 19.3 0.2 0.88 9.2 0.0 2.8 3 0 0 3 3 2 1 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.7 CDF88690.1 - 0.0016 18.1 0.1 0.9 9.1 0.0 2.5 2 0 0 2 2 2 1 NACHT domain DUF815 PF05673.8 CDF88690.1 - 0.0016 17.4 0.0 1.5 7.6 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Zeta_toxin PF06414.7 CDF88690.1 - 0.0019 17.3 0.0 2 7.4 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin AAA_23 PF13476.1 CDF88690.1 - 0.0021 18.4 6.5 0.27 11.5 0.1 3.1 3 0 0 3 3 2 2 AAA domain FtsK_SpoIIIE PF01580.13 CDF88690.1 - 0.0035 16.8 0.0 1.3 8.4 0.0 2.6 2 0 0 2 2 2 1 FtsK/SpoIIIE family FeoB_N PF02421.13 CDF88690.1 - 0.004 16.4 0.1 0.062 12.5 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_33 PF13671.1 CDF88690.1 - 0.0069 16.2 0.0 1.6 8.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 CDF88690.1 - 0.0083 15.5 0.2 2.8 7.2 0.0 2.7 3 0 0 3 3 2 1 AAA domain PRK PF00485.13 CDF88690.1 - 0.0091 15.5 0.0 0.94 8.9 0.0 2.9 3 0 0 3 3 2 1 Phosphoribulokinase / Uridine kinase family Septin PF00735.13 CDF88690.1 - 0.0095 14.9 0.1 1.2 8.1 0.0 2.4 2 0 0 2 2 2 1 Septin Mg_chelatase PF01078.16 CDF88690.1 - 0.0095 15.1 0.0 1.7 7.7 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 CDF88690.1 - 0.016 14.6 0.0 2.9 7.3 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain ATP-synt_ab PF00006.20 CDF88690.1 - 0.017 14.6 0.0 2.5 7.5 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain PduV-EutP PF10662.4 CDF88690.1 - 0.018 14.5 0.1 5.3 6.5 0.0 3.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation APS_kinase PF01583.15 CDF88690.1 - 0.019 14.6 0.4 1.7 8.3 0.0 3.2 3 0 0 3 3 3 0 Adenylylsulphate kinase AAA PF00004.24 CDF88690.1 - 0.039 14.1 0.2 36 4.5 0.0 3.8 4 1 0 4 4 3 0 ATPase family associated with various cellular activities (AAA) T2SE PF00437.15 CDF88690.1 - 0.069 12.0 0.0 4.3 6.1 0.0 2.6 2 0 0 2 2 2 0 Type II/IV secretion system protein SbcCD_C PF13558.1 CDF88690.1 - 0.084 12.7 0.1 26 4.7 0.0 3.5 3 1 0 3 3 3 0 Putative exonuclease SbcCD, C subunit AlaDh_PNT_C PF01262.16 CDF88690.1 - 0.11 12.0 0.3 1.2 8.7 0.0 2.4 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain AAA_24 PF13479.1 CDF88690.1 - 0.18 11.3 0.4 24 4.3 0.3 2.6 2 0 0 2 2 2 0 AAA domain DUF3987 PF13148.1 CDF88690.1 - 0.19 10.2 0.0 2.5 6.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) AAA_30 PF13604.1 CDF88690.1 - 0.22 11.1 0.0 9.2 5.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain ThiF PF00899.16 CDF88691.1 - 5.7e-52 175.1 0.3 1.8e-30 105.5 0.0 2.4 2 0 0 2 2 2 2 ThiF family UBA_e1_C PF09358.5 CDF88691.1 - 1.1e-42 145.1 0.2 5.5e-42 142.8 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin-activating enzyme e1 C-terminal domain UBACT PF02134.16 CDF88691.1 - 1.8e-34 117.1 0.2 9.6e-24 82.7 0.0 2.5 2 0 0 2 2 2 2 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 CDF88691.1 - 4.4e-25 86.8 0.3 1.7e-20 72.0 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin-activating enzyme active site Mog1 PF04603.7 CDF88692.1 - 1.9e-19 70.0 1.1 6.3e-14 52.1 0.1 2.7 1 1 1 2 2 2 2 Ran-interacting Mog1 protein Gly_transf_sug PF04488.10 CDF88693.1 - 1.3e-12 47.9 0.2 1.3e-11 44.7 0.0 2.3 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif IncA PF04156.9 CDF88693.1 - 0.0095 15.5 3.7 0.016 14.8 2.6 1.3 1 0 0 1 1 1 1 IncA protein OmpH PF03938.9 CDF88693.1 - 0.016 15.1 1.0 0.024 14.5 0.7 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF3373 PF11853.3 CDF88693.1 - 0.043 12.3 0.0 0.043 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) DUF2937 PF11157.3 CDF88693.1 - 0.1 11.9 0.8 0.19 11.0 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) DUF922 PF06037.6 CDF88693.1 - 0.16 11.2 1.4 0.16 11.2 0.2 1.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF922) DUF3584 PF12128.3 CDF88693.1 - 0.32 8.2 8.3 0.44 7.8 5.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Septin PF00735.13 CDF88694.1 - 1e-105 352.7 0.0 1.8e-105 352.0 0.0 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 CDF88694.1 - 1.2e-08 34.8 0.0 2.2e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.18 CDF88694.1 - 3.5e-07 30.2 5.5 4.4e-05 23.3 0.3 2.9 2 1 1 3 3 3 2 Dynamin family AIG1 PF04548.11 CDF88694.1 - 1.7e-05 24.0 0.8 2.7e-05 23.3 0.0 1.7 2 0 0 2 2 2 1 AIG1 family DUF258 PF03193.11 CDF88694.1 - 2.8e-05 23.3 1.0 0.0001 21.5 0.7 1.8 1 1 0 1 1 1 1 Protein of unknown function, DUF258 IIGP PF05049.8 CDF88694.1 - 0.00042 19.2 0.1 0.0009 18.1 0.1 1.5 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Miro PF08477.8 CDF88694.1 - 0.0011 19.5 1.2 0.0016 18.9 0.1 1.8 2 0 0 2 2 2 1 Miro-like protein ABC_tran PF00005.22 CDF88694.1 - 0.0018 18.5 0.7 0.0051 17.1 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AAA_10 PF12846.2 CDF88694.1 - 0.0038 16.7 0.0 0.0066 15.9 0.0 1.4 1 0 0 1 1 1 1 AAA-like domain AAA_17 PF13207.1 CDF88694.1 - 0.0097 16.7 1.1 0.025 15.3 0.0 2.2 2 1 0 2 2 2 1 AAA domain T2SE PF00437.15 CDF88694.1 - 0.044 12.6 0.2 0.09 11.6 0.2 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein GTP_EFTU PF00009.22 CDF88694.1 - 0.063 12.7 0.1 0.38 10.1 0.1 2.1 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain FeoB_N PF02421.13 CDF88694.1 - 0.066 12.4 0.3 0.26 10.5 0.2 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B PduV-EutP PF10662.4 CDF88694.1 - 0.074 12.5 1.3 1.9 7.9 0.1 2.5 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.1 CDF88694.1 - 0.075 12.5 0.1 0.24 10.9 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain Yeast-kill-tox PF09207.6 CDF88694.1 - 0.11 12.9 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 Yeast killer toxin FtsK_SpoIIIE PF01580.13 CDF88694.1 - 4.3 6.7 5.6 0.24 10.8 0.1 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family IGPS PF00218.16 CDF88695.1 - 8.4e-92 306.7 0.0 1.1e-91 306.4 0.0 1.1 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase GATase PF00117.23 CDF88695.1 - 1.9e-54 184.0 0.1 3.2e-54 183.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 CDF88695.1 - 3.9e-10 39.5 0.1 1.1e-09 38.1 0.1 1.7 2 0 0 2 2 2 1 Peptidase C26 QRPTase_C PF01729.14 CDF88695.1 - 0.0011 18.4 0.0 0.0028 17.1 0.0 1.6 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain His_biosynth PF00977.16 CDF88695.1 - 0.013 14.7 0.0 0.026 13.8 0.0 1.5 1 0 0 1 1 1 0 Histidine biosynthesis protein Response_reg PF00072.19 CDF88695.1 - 0.14 12.1 0.1 3 7.8 0.0 2.6 2 0 0 2 2 2 0 Response regulator receiver domain Syja_N PF02383.13 CDF88696.1 - 1.1e-83 280.6 0.7 1.5e-83 280.2 0.5 1.2 1 0 0 1 1 1 1 SacI homology domain PUL PF08324.6 CDF88697.1 - 1e-55 188.4 0.9 1.4e-55 188.0 0.6 1.2 1 0 0 1 1 1 1 PUL domain PFU PF09070.6 CDF88697.1 - 2.9e-43 146.5 0.1 7.7e-43 145.2 0.1 1.8 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.27 CDF88697.1 - 3e-38 128.3 15.4 3.1e-07 30.0 0.2 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat BBS2_Mid PF14783.1 CDF88697.1 - 1.7e-05 24.5 0.2 0.1 12.3 0.0 3.8 4 0 0 4 4 4 2 Ciliary BBSome complex subunit 2, middle region Tox-MPTase4 PF15640.1 CDF88697.1 - 0.017 14.7 0.0 0.033 13.8 0.0 1.4 1 0 0 1 1 1 0 Metallopeptidase toxin 4 FoP_duplication PF13865.1 CDF88698.1 - 1.8e-05 25.0 8.3 4.6e-05 23.7 5.8 1.7 1 0 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 RRM_1 PF00076.17 CDF88698.1 - 0.011 15.3 0.7 0.03 13.9 0.0 2.0 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF88698.1 - 0.028 14.2 0.0 0.048 13.5 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Collagen PF01391.13 CDF88698.1 - 0.034 13.7 1.3 0.049 13.1 0.9 1.2 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) RRM_6 PF14259.1 CDF88698.1 - 0.047 13.6 0.1 0.43 10.5 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Host_attach PF10116.4 CDF88698.1 - 0.15 12.3 1.6 0.29 11.3 1.1 1.5 1 0 0 1 1 1 0 Protein required for attachment to host cells FCP1_C PF09309.5 CDF88698.1 - 0.5 9.6 5.5 0.75 9.0 3.8 1.3 1 0 0 1 1 1 0 FCP1, C-terminal Mito_carr PF00153.22 CDF88699.1 - 3.4e-45 151.6 6.6 2e-19 69.0 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.22 CDF88700.1 - 1.4e-59 197.7 3.0 7.8e-20 70.3 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DHODB_Fe-S_bind PF10418.4 CDF88700.1 - 2.3 7.7 6.7 0.5 9.8 0.5 2.7 3 0 0 3 3 3 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B Aa_trans PF01490.13 CDF88701.1 - 8.2e-28 97.0 34.4 1e-27 96.6 23.8 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2663 PF10864.3 CDF88701.1 - 0.15 12.2 4.5 0.48 10.6 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2663) MFS_1 PF07690.11 CDF88702.1 - 5.3e-29 101.0 25.9 6.6e-29 100.7 17.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily OPT PF03169.10 CDF88707.1 - 6e-126 421.3 51.4 6.9e-126 421.1 35.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUP PF00674.13 CDF88708.1 - 3.8e-07 30.0 0.6 3.8e-07 30.0 0.4 2.2 2 0 0 2 2 2 1 DUP family ApbA_C PF08546.6 CDF88710.1 - 2.7e-26 92.0 0.0 4e-26 91.4 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 CDF88710.1 - 4.8e-22 78.0 0.1 6.6e-22 77.5 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.15 CDF88710.1 - 0.047 13.7 0.1 0.11 12.6 0.0 1.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Amidase PF01425.16 CDF88711.1 - 1.5e-95 320.6 0.0 1.8e-95 320.4 0.0 1.0 1 0 0 1 1 1 1 Amidase MFS_1 PF07690.11 CDF88712.1 - 1.4e-30 106.1 25.8 2.7e-29 102.0 16.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 CDF88712.1 - 0.00016 20.0 0.9 0.00024 19.4 0.6 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) UPF0239 PF06783.6 CDF88712.1 - 0.18 11.7 0.0 0.39 10.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) Oxidored_FMN PF00724.15 CDF88713.1 - 8.5e-72 241.9 0.0 1.1e-71 241.6 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family NMO PF03060.10 CDF88714.1 - 4.8e-77 259.3 0.0 5.3e-77 259.1 0.0 1.0 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.20 CDF88714.1 - 5.2e-07 28.8 0.2 0.00089 18.2 0.0 2.1 2 0 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain DHO_dh PF01180.16 CDF88714.1 - 8.4e-07 28.2 0.3 1.8e-06 27.1 0.2 1.8 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase His_biosynth PF00977.16 CDF88714.1 - 0.024 13.9 0.0 0.09 12.0 0.0 1.8 2 0 0 2 2 2 0 Histidine biosynthesis protein NanE PF04131.9 CDF88714.1 - 0.052 12.5 0.5 0.099 11.5 0.0 1.6 2 0 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase DUF561 PF04481.7 CDF88714.1 - 0.074 11.9 0.3 0.24 10.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF561) mRNA_triPase PF02940.10 CDF88716.1 - 6e-37 127.4 3.6 6e-37 127.4 2.5 1.8 2 0 0 2 2 2 1 mRNA capping enzyme, beta chain DUF544 PF04424.8 CDF88716.1 - 0.0035 17.1 0.1 0.01 15.6 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF544) Membr_traf_MHD PF10540.4 CDF88717.1 - 1.7e-15 57.0 0.0 7.7e-15 54.8 0.0 2.2 1 0 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.25 CDF88717.1 - 7.5e-10 38.5 0.0 2.3e-09 36.9 0.0 1.8 1 0 0 1 1 1 1 C2 domain SWIB PF02201.13 CDF88718.1 - 6e-26 89.9 0.0 6e-26 89.9 0.0 1.8 2 0 0 2 2 2 1 SWIB/MDM2 domain DEK_C PF08766.6 CDF88718.1 - 1.7e-10 40.5 0.1 5.7e-10 38.8 0.0 1.9 2 0 0 2 2 2 1 DEK C terminal domain DUF1917 PF08939.5 CDF88718.1 - 0.035 13.8 3.3 0.11 12.2 2.3 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1917) Peroxin-13_N PF04088.8 CDF88718.1 - 2.6 8.0 5.0 4.6 7.1 0.3 2.3 2 0 0 2 2 2 0 Peroxin 13, N-terminal region RRS1 PF04939.7 CDF88719.1 - 9.8e-64 213.7 5.3 1.1e-63 213.5 3.7 1.0 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) RE_EcoO109I PF14511.1 CDF88720.1 - 0.025 13.9 0.0 0.25 10.7 0.0 2.4 2 0 0 2 2 2 0 Type II restriction endonuclease EcoO109I A1_Propeptide PF07966.7 CDF88720.1 - 0.045 13.5 0.1 0.19 11.5 0.0 2.2 2 0 0 2 2 2 0 A1 Propeptide VPS11_C PF12451.3 CDF88721.1 - 1.6e-10 40.6 0.1 5.3e-10 38.9 0.1 2.0 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-RING_5 PF14634.1 CDF88721.1 - 5.3e-05 22.8 8.4 0.00016 21.3 5.8 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.1 CDF88721.1 - 0.0015 18.3 6.3 0.0037 17.0 4.4 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.1 CDF88721.1 - 0.0023 17.7 7.3 0.0067 16.2 5.0 1.9 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 CDF88721.1 - 0.0077 16.2 7.2 0.019 14.9 5.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDF88721.1 - 0.0089 15.6 8.9 0.023 14.3 6.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 CDF88721.1 - 0.011 15.5 2.2 0.021 14.6 1.5 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.24 CDF88721.1 - 0.016 14.9 6.9 0.034 13.8 4.8 1.6 1 0 0 1 1 1 0 PHD-finger zf-rbx1 PF12678.2 CDF88721.1 - 0.035 14.2 4.3 0.08 13.0 3.0 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger TPR_11 PF13414.1 CDF88721.1 - 0.13 11.9 0.0 0.33 10.6 0.0 1.7 1 0 0 1 1 1 0 TPR repeat zf-RING_UBOX PF13445.1 CDF88721.1 - 0.13 11.9 3.0 0.45 10.2 2.1 2.0 1 0 0 1 1 1 0 RING-type zinc-finger zf-MIZ PF02891.15 CDF88721.1 - 1.4 8.5 5.3 4 7.0 3.7 1.9 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger S10_plectin PF03501.10 CDF88722.1 - 1.5e-42 143.3 0.5 1.7e-42 143.1 0.3 1.0 1 0 0 1 1 1 1 Plectin/S10 domain PadR PF03551.9 CDF88722.1 - 0.025 14.3 1.3 0.025 14.3 0.9 1.8 2 1 0 2 2 2 0 Transcriptional regulator PadR-like family YjcQ PF09639.5 CDF88722.1 - 0.056 13.5 0.1 0.085 12.9 0.1 1.3 1 0 0 1 1 1 0 YjcQ protein tRNA-synt_1c_C PF03950.13 CDF88722.1 - 0.092 12.4 0.0 0.1 12.2 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), anti-codon binding domain DUF505 PF04458.7 CDF88722.1 - 0.12 10.4 0.3 0.14 10.2 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF505) Mpv17_PMP22 PF04117.7 CDF88723.1 - 1.2e-21 76.0 1.1 1.2e-21 76.0 0.8 2.9 3 1 0 3 3 3 1 Mpv17 / PMP22 family HTH_Crp_2 PF13545.1 CDF88723.1 - 0.14 11.9 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain P5-ATPase PF12409.3 CDF88724.1 - 1.2e-37 128.3 0.1 1.4e-36 124.9 0.0 2.7 3 0 0 3 3 3 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.15 CDF88724.1 - 4.8e-28 97.7 0.0 7.7e-28 97.0 0.0 1.3 1 0 0 1 1 1 1 E1-E2 ATPase HAD PF12710.2 CDF88724.1 - 1.5e-23 84.0 0.0 3.2e-23 82.8 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CDF88724.1 - 1e-16 61.9 0.0 8.8e-13 49.1 0.0 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CDF88724.1 - 4e-06 26.6 0.0 9.8e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 CDF88724.1 - 0.003 16.9 0.0 0.0069 15.8 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 CDF88724.1 - 0.021 14.3 0.2 0.97 8.9 0.0 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase S1 PF00575.18 CDF88725.1 - 9.9e-56 185.7 33.2 9.7e-12 44.8 0.5 13.3 12 1 0 12 12 12 8 S1 RNA binding domain Suf PF05843.9 CDF88725.1 - 2.6e-05 24.1 21.1 0.017 14.8 0.1 4.4 2 1 2 4 4 4 3 Suppressor of forked protein (Suf) TPR_19 PF14559.1 CDF88725.1 - 3.2e-05 24.1 0.0 0.29 11.5 0.0 3.0 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 CDF88725.1 - 0.00016 21.9 0.1 3.2 8.6 0.0 4.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 CDF88725.1 - 0.00076 19.3 0.6 0.61 10.0 0.0 3.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 CDF88725.1 - 0.0072 16.9 0.0 1.6 9.5 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 CDF88725.1 - 0.0084 15.7 0.0 4.3 7.0 0.0 2.8 2 0 0 2 2 2 2 TPR repeat TPR_3 PF07720.7 CDF88725.1 - 0.1 12.4 0.1 0.27 11.1 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.7 CDF88725.1 - 1.3 8.8 5.9 0.63 9.8 1.8 2.2 2 0 0 2 2 2 0 Mad3/BUB1 homology region 1 RNA_pol_Rbc25 PF08292.7 CDF88725.1 - 3.4 7.8 9.6 20 5.3 0.0 5.5 6 0 0 6 6 6 0 RNA polymerase III subunit Rpc25 RrnaAD PF00398.15 CDF88726.1 - 4.1e-65 219.4 0.0 4.7e-65 219.2 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase TAFII55_N PF04658.8 CDF88727.1 - 7.8e-54 181.5 0.0 7.8e-54 181.5 0.0 2.2 2 0 0 2 2 2 1 TAFII55 protein conserved region NCU-G1 PF15065.1 CDF88727.1 - 0.12 11.0 0.7 0.26 9.9 0.5 1.5 1 0 0 1 1 1 0 Lysosomal transcription factor, NCU-G1 SNF2_N PF00176.18 CDF88728.1 - 1.3e-84 283.5 0.6 1.3e-84 283.5 0.4 2.7 3 0 0 3 3 3 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CDF88728.1 - 2.6e-18 65.6 0.1 7.7e-17 60.9 0.0 3.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain Bromodomain PF00439.20 CDF88728.1 - 1.9e-16 59.7 0.2 6.4e-16 58.0 0.1 1.9 1 0 0 1 1 1 1 Bromodomain SnAC PF14619.1 CDF88728.1 - 7.8e-16 58.0 1.1 7.8e-16 58.0 0.8 4.6 4 1 0 5 5 5 1 Snf2-ATP coupling, chromatin remodelling complex Pyridoxal_deC PF00282.14 CDF88729.1 - 1.9e-27 95.6 0.0 3e-27 95.0 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_1_2 PF00155.16 CDF88729.1 - 2.9e-05 23.1 0.0 6e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 CDF88729.1 - 0.00054 19.1 0.0 0.00082 18.5 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase SLA_LP_auto_ag PF05889.8 CDF88729.1 - 0.02 13.4 0.0 0.038 12.4 0.0 1.4 1 0 0 1 1 1 0 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) Aminotran_5 PF00266.14 CDF88729.1 - 0.028 13.1 0.0 0.062 12.0 0.0 1.6 1 0 0 1 1 1 0 Aminotransferase class-V DUF2357 PF09823.4 CDF88729.1 - 0.16 11.0 0.0 0.28 10.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2357) adh_short PF00106.20 CDF88731.1 - 1.2e-31 109.8 0.0 1.6e-31 109.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CDF88731.1 - 3.1e-14 53.3 0.0 4.1e-14 52.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CDF88731.1 - 1.3e-09 37.9 0.0 1.7e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.5 CDF88731.1 - 0.00025 20.2 0.0 0.00069 18.8 0.0 1.7 2 1 0 2 2 2 1 Fungal family of unknown function (DUF1776) Polysacc_synt_2 PF02719.10 CDF88731.1 - 0.00066 18.6 0.1 0.00098 18.1 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.16 CDF88731.1 - 0.0035 16.7 0.2 0.012 15.0 0.0 2.0 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.3 CDF88731.1 - 0.011 15.5 0.2 0.025 14.3 0.2 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Saccharop_dh PF03435.13 CDF88731.1 - 0.084 11.8 0.1 0.11 11.3 0.1 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase AMMECR1 PF01871.12 CDF88732.1 - 1.3e-33 115.5 0.0 1.7e-33 115.1 0.0 1.2 1 0 0 1 1 1 1 AMMECR1 Thioredoxin PF00085.15 CDF88733.1 - 1.9e-20 72.4 1.0 4.9e-20 71.1 0.2 2.0 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.1 CDF88733.1 - 1.2e-07 31.8 0.6 1.2e-06 28.6 0.3 2.4 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 CDF88733.1 - 3.9e-06 26.9 0.8 0.00032 20.7 0.1 3.1 2 1 1 3 3 3 1 Thioredoxin-like Thioredoxin_7 PF13899.1 CDF88733.1 - 1.1e-05 25.3 0.1 3.3e-05 23.8 0.1 1.8 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_6 PF13848.1 CDF88733.1 - 0.00024 20.9 3.1 0.066 13.0 0.1 3.1 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_3 PF13192.1 CDF88733.1 - 0.0078 16.0 1.0 0.032 14.0 0.3 2.1 2 0 0 2 2 2 1 Thioredoxin domain DSBA PF01323.15 CDF88733.1 - 0.027 14.0 0.1 2.3 7.7 0.0 2.1 1 1 1 2 2 2 0 DSBA-like thioredoxin domain Glutaredoxin PF00462.19 CDF88733.1 - 0.051 13.5 0.2 0.13 12.2 0.1 1.8 1 0 0 1 1 1 0 Glutaredoxin PIN_4 PF13638.1 CDF88734.1 - 6.2e-29 100.7 0.4 1.5e-28 99.5 0.3 1.7 1 0 0 1 1 1 1 PIN domain Ribosomal_S28e PF01200.13 CDF88735.1 - 1e-33 114.8 3.4 1.1e-33 114.7 2.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e S_layer_C PF05124.7 CDF88735.1 - 0.13 11.8 0.1 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 S-layer like family, C-terminal region Red1 PF07964.6 CDF88736.1 - 2.7e-137 458.8 21.9 2.6e-136 455.6 15.2 1.9 1 1 0 1 1 1 1 Rec10 / Red1 REV PF00424.13 CDF88736.1 - 0.068 13.0 8.7 0.031 14.1 3.1 2.5 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) tRNA-synt_1c PF00749.16 CDF88737.1 - 6.5e-111 369.9 0.0 9.9e-111 369.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.10 CDF88737.1 - 6e-55 185.2 3.3 1e-54 184.5 2.3 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.13 CDF88737.1 - 3.8e-30 104.8 0.3 6.2e-29 100.8 0.0 2.7 2 1 1 3 3 3 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.10 CDF88737.1 - 5.4e-18 65.4 4.1 2e-17 63.6 2.8 2.0 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 TMA7 PF09072.5 CDF88738.1 - 1e-22 80.3 20.5 1.1e-22 80.2 14.2 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 MRC1 PF09444.5 CDF88738.1 - 0.019 15.2 2.3 0.021 15.1 1.6 1.1 1 0 0 1 1 1 0 MRC1-like domain YajC PF02699.10 CDF88738.1 - 4.2 7.1 6.8 0.24 11.1 0.3 1.9 2 0 0 2 2 2 0 Preprotein translocase subunit Ras PF00071.17 CDF88739.1 - 5.4e-57 191.7 0.6 6.8e-57 191.3 0.5 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDF88739.1 - 5.2e-22 78.5 0.5 1.2e-21 77.3 0.1 1.7 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 CDF88739.1 - 1.4e-15 57.0 0.4 1.8e-15 56.6 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 CDF88739.1 - 1.9e-06 27.4 0.1 1.1e-05 24.9 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CDF88739.1 - 6.8e-06 26.0 0.1 1.1e-05 25.3 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 CDF88739.1 - 1.5e-05 24.2 0.2 1.9e-05 23.9 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 CDF88739.1 - 3.3e-05 23.1 0.2 7.7e-05 21.9 0.0 1.7 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit Arch_ATPase PF01637.13 CDF88739.1 - 0.00018 21.2 1.0 0.00054 19.7 0.1 1.8 2 0 0 2 2 2 1 Archaeal ATPase PduV-EutP PF10662.4 CDF88739.1 - 0.0026 17.2 0.6 0.022 14.2 0.4 2.1 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.1 CDF88739.1 - 0.0043 17.2 0.0 0.016 15.3 0.0 1.9 1 1 0 2 2 2 1 AAA domain DUF258 PF03193.11 CDF88739.1 - 0.017 14.3 0.0 0.027 13.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_24 PF13479.1 CDF88739.1 - 0.02 14.5 0.1 0.039 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 CDF88739.1 - 0.038 13.9 0.0 0.1 12.5 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.7 CDF88739.1 - 0.091 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain DAGK_cat PF00781.19 CDF88740.1 - 1.7e-25 88.9 0.0 5.4e-25 87.3 0.0 1.8 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain DUF1682 PF07946.9 CDF88740.1 - 0.013 14.3 0.0 0.023 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Cpn60_TCP1 PF00118.19 CDF88741.1 - 4.1e-119 398.3 6.9 4.7e-119 398.1 4.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF4164 PF13747.1 CDF88742.1 - 0.55 10.4 8.2 0.17 12.0 1.2 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4164) Reo_sigmaC PF04582.7 CDF88742.1 - 1.4 8.0 5.6 0.85 8.7 1.5 1.9 1 1 0 2 2 2 0 Reovirus sigma C capsid protein DnaJ PF00226.26 CDF88743.1 - 1.5e-23 82.3 0.4 2.3e-23 81.6 0.3 1.3 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 CDF88743.1 - 3.6e-21 74.8 0.3 5.5e-16 58.2 0.0 3.5 3 1 1 4 4 4 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 CDF88743.1 - 6.1e-12 45.4 16.4 1e-09 38.2 11.5 3.1 1 1 2 3 3 3 3 DnaJ central domain Cytochrom_c3_2 PF14537.1 CDF88743.1 - 0.3 11.4 7.6 1.6 9.1 5.3 2.1 1 1 1 2 2 2 0 Cytochrome c3 Cytochrome_C7 PF14522.1 CDF88743.1 - 2.9 7.6 7.7 1.5 8.4 2.2 2.2 2 0 0 2 2 2 0 Cytochrome c7 Securin PF04856.8 CDF88744.1 - 9.3e-22 77.8 8.8 2.5e-21 76.4 6.1 1.6 1 1 0 1 1 1 1 Securin sister-chromatid separation inhibitor Ribosomal_L34 PF00468.12 CDF88746.1 - 9.9e-18 63.5 10.2 1.8e-17 62.7 7.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L34 SUI1 PF01253.17 CDF88747.1 - 9.5e-13 47.7 0.0 2.6e-12 46.3 0.0 1.8 1 0 0 1 1 1 1 Translation initiation factor SUI1 SWIB PF02201.13 CDF88747.1 - 0.0033 17.0 0.2 0.009 15.6 0.1 1.8 2 0 0 2 2 2 1 SWIB/MDM2 domain Apc4 PF12896.2 CDF88748.1 - 4.2e-20 71.9 0.5 1.3e-19 70.3 0.3 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 MFS_1 PF07690.11 CDF88751.1 - 3e-47 161.0 41.0 3.5e-47 160.8 27.7 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CDF88751.1 - 1.5e-14 53.4 6.0 1.5e-14 53.4 4.2 2.8 3 1 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.8 CDF88751.1 - 4.4e-11 41.7 8.8 6.2e-11 41.2 6.1 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) GNVR PF13807.1 CDF88751.1 - 0.12 12.1 0.0 0.37 10.5 0.0 1.8 1 0 0 1 1 1 0 G-rich domain on putative tyrosine kinase HEAT_2 PF13646.1 CDF88752.1 - 1.5e-19 70.0 3.0 2e-08 34.4 0.0 6.7 5 2 2 7 7 7 5 HEAT repeats HEAT_EZ PF13513.1 CDF88752.1 - 2.2e-18 66.1 11.7 2.1e-06 28.0 0.0 11.4 11 2 2 13 13 13 4 HEAT-like repeat HEAT PF02985.17 CDF88752.1 - 2.4e-14 52.0 20.2 0.0074 16.2 0.0 11.1 13 0 0 13 13 13 4 HEAT repeat RIX1 PF08167.7 CDF88752.1 - 7.5e-09 35.4 0.3 0.016 14.8 0.0 6.3 6 1 1 7 7 7 1 rRNA processing/ribosome biogenesis MMS19_C PF12460.3 CDF88752.1 - 2.8e-07 29.6 7.9 0.00095 18.0 1.7 4.0 4 1 1 5 5 5 2 RNAPII transcription regulator C-terminal Vac14_Fab1_bd PF12755.2 CDF88752.1 - 2.9e-06 27.5 0.3 0.033 14.5 0.0 5.5 5 2 4 9 9 9 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.3 CDF88752.1 - 1.9e-05 24.1 1.3 0.051 12.9 0.1 4.6 4 1 0 4 4 4 1 CLASP N terminal Arm PF00514.18 CDF88752.1 - 3.3e-05 23.5 2.7 3.1 7.7 0.0 6.7 7 0 0 7 7 7 1 Armadillo/beta-catenin-like repeat DNA_alkylation PF08713.6 CDF88752.1 - 0.036 13.5 0.0 0.19 11.1 0.0 2.3 2 0 0 2 2 2 0 DNA alkylation repair enzyme EST1_DNA_bind PF10373.4 CDF88752.1 - 0.049 12.8 0.3 0.15 11.2 0.0 1.9 2 0 0 2 2 2 0 Est1 DNA/RNA binding domain ABC_membrane PF00664.18 CDF88753.1 - 2.6e-65 220.5 41.3 9e-33 113.8 10.5 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 CDF88753.1 - 7.7e-45 152.5 4.4 5.1e-28 98.0 0.1 3.5 3 1 0 3 3 2 2 ABC transporter SMC_N PF02463.14 CDF88753.1 - 1.6e-09 37.3 0.0 0.0012 18.0 0.0 3.9 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 CDF88753.1 - 8.4e-09 36.0 15.3 0.00012 22.4 4.8 3.7 3 1 0 3 3 3 2 AAA domain AAA_29 PF13555.1 CDF88753.1 - 1.7e-06 27.4 0.5 0.035 13.6 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.1 CDF88753.1 - 4.1e-06 26.9 0.3 4.1e-06 26.9 0.2 5.2 4 2 1 5 5 4 1 AAA domain AAA_17 PF13207.1 CDF88753.1 - 3.4e-05 24.6 8.2 0.011 16.4 0.0 4.0 4 0 0 4 4 2 2 AAA domain DUF258 PF03193.11 CDF88753.1 - 6.7e-05 22.1 0.1 0.18 10.9 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function, DUF258 T2SE PF00437.15 CDF88753.1 - 8.2e-05 21.6 0.0 0.06 12.2 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_25 PF13481.1 CDF88753.1 - 9.6e-05 21.8 0.0 0.065 12.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.1 CDF88753.1 - 0.00016 21.3 2.1 1.2 8.6 0.0 3.7 4 0 0 4 4 4 2 AAA domain AAA_22 PF13401.1 CDF88753.1 - 0.00017 21.6 3.1 0.75 9.9 0.1 3.4 2 1 0 2 2 2 2 AAA domain Miro PF08477.8 CDF88753.1 - 0.0014 19.1 0.1 1.7 9.1 0.0 2.9 2 0 0 2 2 2 1 Miro-like protein IstB_IS21 PF01695.12 CDF88753.1 - 0.0037 16.7 0.0 0.35 10.2 0.0 2.8 3 0 0 3 3 2 1 IstB-like ATP binding protein MMR_HSR1 PF01926.18 CDF88753.1 - 0.0041 17.0 1.8 0.18 11.7 0.1 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.13 CDF88753.1 - 0.0044 16.5 0.1 0.51 9.7 0.0 2.8 2 0 0 2 2 2 1 FtsK/SpoIIIE family ATP-synt_ab PF00006.20 CDF88753.1 - 0.0097 15.4 0.1 4.3 6.7 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_16 PF13191.1 CDF88753.1 - 0.011 15.7 0.1 0.87 9.5 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain AAA_11 PF13086.1 CDF88753.1 - 0.011 15.2 0.2 0.3 10.6 0.0 3.0 3 1 0 3 3 3 0 AAA domain UPF0079 PF02367.12 CDF88753.1 - 0.026 14.1 0.1 0.21 11.1 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 RNA_helicase PF00910.17 CDF88753.1 - 0.029 14.5 0.1 16 5.6 0.0 3.0 2 0 0 2 2 2 0 RNA helicase AAA PF00004.24 CDF88753.1 - 0.033 14.3 0.7 1.2 9.2 0.0 3.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 CDF88753.1 - 0.037 13.9 0.6 5.3 6.9 0.0 3.3 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.12 CDF88753.1 - 0.04 13.7 2.5 0.11 12.3 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF87 NTPase_1 PF03266.10 CDF88753.1 - 0.045 13.4 0.7 4.5 6.9 0.1 2.5 2 0 0 2 2 2 0 NTPase cobW PF02492.14 CDF88753.1 - 0.055 12.9 0.5 2.2 7.6 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.12 CDF88753.1 - 0.11 11.9 6.6 2.5 7.5 0.0 3.4 4 0 0 4 4 3 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.1 CDF88753.1 - 0.14 12.4 0.0 0.14 12.4 0.0 4.7 5 0 0 5 5 4 0 AAA domain AAA_19 PF13245.1 CDF88753.1 - 0.16 11.7 0.1 1 9.1 0.0 2.3 2 0 0 2 2 2 0 Part of AAA domain Dynamin_N PF00350.18 CDF88753.1 - 1.8 8.3 12.7 4.2 7.1 0.1 4.0 4 0 0 4 4 4 0 Dynamin family MobB PF03205.9 CDF88753.1 - 2.6 7.7 6.1 10 5.8 0.1 3.0 3 0 0 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B PRK PF00485.13 CDF88753.1 - 5 6.6 7.8 2.3 7.7 0.0 3.4 3 0 0 3 3 3 0 Phosphoribulokinase / Uridine kinase family ArgK PF03308.11 CDF88753.1 - 7.4 5.2 5.7 0.71 8.6 0.0 2.1 3 0 0 3 3 3 0 ArgK protein eIF-3c_N PF05470.7 CDF88754.1 - 6e-160 533.2 17.4 1.3e-123 413.1 1.9 2.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.22 CDF88754.1 - 3.4e-13 49.8 0.5 1.7e-12 47.6 0.0 2.6 2 0 0 2 2 2 1 PCI domain DUF1548 PF07579.6 CDF88754.1 - 0.015 15.3 1.8 0.4 10.7 0.1 3.2 2 1 0 2 2 2 0 Domain of Unknown Function (DUF1548) Glyco_hydro_17 PF00332.13 CDF88755.1 - 5.5e-69 232.5 3.0 6.3e-69 232.3 2.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 WXG100 PF06013.7 CDF88755.1 - 0.32 11.0 2.5 11 6.0 0.0 2.4 2 0 0 2 2 2 0 Proteins of 100 residues with WXG Methyltrn_RNA_3 PF02598.12 CDF88756.1 - 1.4e-90 303.5 0.1 1.6e-90 303.3 0.1 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase DUF3832 PF12909.2 CDF88756.1 - 0.02 14.9 0.1 0.043 13.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3832) MVIN PF03023.9 CDF88756.1 - 0.02 13.2 0.0 0.029 12.8 0.0 1.1 1 0 0 1 1 1 0 MviN-like protein IPP-2 PF04979.9 CDF88757.1 - 3.7e-12 46.6 9.6 3.7e-12 46.6 6.6 1.9 1 1 1 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) PEHE PF15275.1 CDF88757.1 - 0.034 14.5 5.6 0.034 14.5 3.9 2.2 2 1 0 2 2 2 0 PEHE domain SURF4 PF02077.10 CDF88758.1 - 1.9e-104 348.7 12.2 2.1e-104 348.6 8.4 1.0 1 0 0 1 1 1 1 SURF4 family CytochromB561_N PF09786.4 CDF88758.1 - 0.19 10.1 0.3 0.25 9.7 0.2 1.2 1 0 0 1 1 1 0 Cytochrome B561, N terminal DnaJ PF00226.26 CDF88759.1 - 1.6e-17 62.9 0.5 1.6e-17 62.9 0.4 2.8 3 0 0 3 3 3 1 DnaJ domain DUF3336 PF11815.3 CDF88761.1 - 8.9e-27 93.3 0.0 1.9e-26 92.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.17 CDF88761.1 - 5.1e-08 33.0 0.0 9.7e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase Proteasome PF00227.21 CDF88762.1 - 2.6e-47 160.5 0.0 3.2e-47 160.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 CDF88762.1 - 9.6e-13 47.1 0.2 1.9e-12 46.2 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Bul1_N PF04425.7 CDF88763.1 - 5.4e-62 209.7 0.2 1.4e-61 208.4 0.1 1.6 1 1 0 1 1 1 1 Bul1 N terminus Bul1_C PF04426.7 CDF88763.1 - 1.5e-36 125.9 3.8 1.5e-20 73.5 0.1 2.3 1 1 1 2 2 2 2 Bul1 C terminus Arrestin_N PF00339.24 CDF88763.1 - 0.006 16.4 0.5 0.035 13.9 0.0 2.3 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain RNase_H PF00075.19 CDF88764.1 - 4.8e-28 98.1 0.1 1e-27 97.1 0.0 1.6 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.11 CDF88764.1 - 1e-20 73.4 2.9 5e-14 52.0 0.3 2.7 2 0 0 2 2 2 2 Caulimovirus viroplasmin RVT_3 PF13456.1 CDF88764.1 - 0.0099 15.6 0.0 5.3 6.8 0.0 2.5 2 0 0 2 2 2 2 Reverse transcriptase-like CybS PF05328.7 CDF88765.1 - 1.2e-52 177.0 0.0 1.4e-52 176.8 0.0 1.1 1 0 0 1 1 1 1 CybS Acyltransferase PF01553.16 CDF88766.1 - 0.00058 19.3 0.0 0.0014 18.0 0.0 1.7 1 1 0 1 1 1 1 Acyltransferase LRR_6 PF13516.1 CDF88767.1 - 3.2e-14 51.3 10.9 0.054 13.5 0.1 7.7 8 0 0 8 8 8 5 Leucine Rich repeat LRR_4 PF12799.2 CDF88767.1 - 4.5e-12 45.2 18.1 0.0072 15.9 0.5 6.6 6 1 1 7 7 7 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CDF88767.1 - 2.2e-11 43.3 9.8 0.0024 17.5 0.2 4.7 4 0 0 4 4 4 3 Leucine rich repeat LRR_1 PF00560.28 CDF88767.1 - 1.5e-08 33.4 12.7 1 9.6 0.0 7.2 7 1 0 7 7 7 4 Leucine Rich Repeat LRR_7 PF13504.1 CDF88767.1 - 2.7e-06 26.6 6.1 11 6.7 0.0 7.0 6 0 0 6 6 6 1 Leucine rich repeat Fe_dep_repr_C PF02742.10 CDF88767.1 - 1.1 9.0 4.6 3 7.5 3.2 1.7 1 0 0 1 1 1 0 Iron dependent repressor, metal binding and dimerisation domain MBF1 PF08523.5 CDF88768.1 - 1.2e-25 89.3 1.2 1.2e-25 89.3 0.8 1.8 2 1 1 3 3 3 1 Multiprotein bridging factor 1 HTH_3 PF01381.17 CDF88768.1 - 9.9e-13 47.7 0.2 1.6e-12 47.0 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.1 CDF88768.1 - 6.2e-06 26.3 0.0 1.5e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.2 CDF88768.1 - 0.0021 18.0 0.1 0.0032 17.4 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_24 PF13412.1 CDF88768.1 - 0.1 12.0 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MARVEL PF01284.18 CDF88769.1 - 2.4e-28 98.7 14.5 3e-28 98.4 10.0 1.1 1 0 0 1 1 1 1 Membrane-associating domain BAR_2 PF10455.4 CDF88771.1 - 1.6e-92 309.4 9.4 2.2e-92 309.0 6.5 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.13 CDF88771.1 - 1.2e-07 31.5 15.3 7.3e-06 25.6 7.6 3.0 2 1 0 2 2 2 2 BAR domain Herpes_UL6 PF01763.11 CDF88771.1 - 0.00094 17.4 2.2 0.0018 16.5 1.5 1.5 1 0 0 1 1 1 1 Herpesvirus UL6 like DUF4446 PF14584.1 CDF88771.1 - 1 9.1 4.5 0.62 9.8 1.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4446) SYF2 PF08231.7 CDF88772.1 - 3.8e-10 40.1 18.0 3.8e-10 40.1 12.5 1.6 1 1 0 1 1 1 1 SYF2 splicing factor Utp8 PF10395.4 CDF88773.1 - 1.1e-204 681.6 14.2 1.2e-204 681.4 9.9 1.0 1 0 0 1 1 1 1 Utp8 family VEFS-Box PF09733.4 CDF88773.1 - 0.0013 18.4 0.5 0.018 14.7 0.1 2.8 3 0 0 3 3 3 1 VEFS-Box of polycomb protein DUF2305 PF10230.4 CDF88774.1 - 2.9e-67 226.8 0.4 3.4e-67 226.6 0.3 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Abhydrolase_6 PF12697.2 CDF88774.1 - 9.8e-12 45.2 0.0 1.3e-11 44.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CDF88774.1 - 9.4e-06 25.4 0.0 1.5e-05 24.8 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF1057 PF06342.7 CDF88774.1 - 0.00096 18.0 0.2 0.19 10.5 0.0 2.1 2 0 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF1057) Thioesterase PF00975.15 CDF88774.1 - 0.0018 18.5 0.0 0.0031 17.7 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Lipase_3 PF01764.20 CDF88774.1 - 0.0061 16.1 0.0 0.012 15.2 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.8 CDF88774.1 - 0.019 14.5 0.2 0.037 13.6 0.1 1.5 1 0 0 1 1 1 0 PGAP1-like protein DUF3089 PF11288.3 CDF88774.1 - 0.025 13.7 0.0 0.04 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Med9 PF07544.8 CDF88774.1 - 0.079 12.6 0.7 0.29 10.8 0.1 2.1 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 NRDE PF05742.7 CDF88775.1 - 3e-53 180.8 0.0 3.5e-53 180.6 0.0 1.0 1 0 0 1 1 1 1 NRDE protein CENP-O PF09496.5 CDF88776.1 - 2.9e-18 65.8 0.5 7.4e-18 64.5 0.1 1.9 2 0 0 2 2 2 1 Cenp-O kinetochore centromere component GAS PF13851.1 CDF88776.1 - 0.018 14.2 0.3 0.037 13.2 0.2 1.5 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Scs3p PF10261.4 CDF88777.1 - 3.8e-38 130.8 13.9 1.5e-37 128.8 9.6 2.0 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM PAP2 PF01569.16 CDF88777.1 - 0.0059 16.2 4.4 0.034 13.8 1.2 2.3 2 0 0 2 2 2 1 PAP2 superfamily Orai-1 PF07856.7 CDF88777.1 - 0.027 14.0 1.0 0.048 13.2 0.7 1.4 1 0 0 1 1 1 0 Mediator of CRAC channel activity Prenyltrans PF00432.16 CDF88778.1 - 4.5e-28 96.4 2.6 7.6e-09 34.9 0.3 4.7 4 0 0 4 4 4 4 Prenyltransferase and squalene oxidase repeat Prenyltrans_1 PF13243.1 CDF88778.1 - 2.9e-25 88.4 0.0 1.9e-11 43.9 0.0 5.3 3 3 2 5 5 5 4 Prenyltransferase-like Prenyltrans_2 PF13249.1 CDF88778.1 - 1.6e-24 86.4 0.1 2.6e-16 60.0 0.0 4.4 3 1 1 4 4 4 4 Prenyltransferase-like A2M_comp PF07678.9 CDF88778.1 - 0.0013 18.0 0.1 0.0065 15.7 0.0 2.1 2 1 0 3 3 3 1 A-macroglobulin complement component Pec_lyase PF09492.5 CDF88778.1 - 0.0027 16.9 0.3 13 4.8 0.0 3.9 2 1 2 4 4 4 2 Pectic acid lyase Ubiq-assoc PF09145.5 CDF88779.1 - 2.5e-19 68.8 1.0 2.5e-19 68.8 0.7 1.9 2 0 0 2 2 2 1 Ubiquitin-associated TPR_11 PF13414.1 CDF88779.1 - 6.8e-09 35.2 0.3 2.2e-06 27.2 0.1 2.6 2 0 0 2 2 2 2 TPR repeat TPR_12 PF13424.1 CDF88779.1 - 1.1e-06 28.5 0.5 8.7e-05 22.3 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 CDF88779.1 - 2.5e-05 23.8 1.6 0.73 9.8 0.1 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat DnaJ PF00226.26 CDF88779.1 - 0.0016 18.1 0.3 0.0052 16.4 0.0 2.0 2 0 0 2 2 2 1 DnaJ domain TPR_14 PF13428.1 CDF88779.1 - 0.003 18.0 0.0 11 7.0 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.23 CDF88779.1 - 0.0044 16.5 5.8 8.9 6.1 0.2 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat DUF3856 PF12968.2 CDF88779.1 - 0.014 15.2 0.1 0.084 12.6 0.1 2.1 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) TPR_16 PF13432.1 CDF88779.1 - 0.024 15.3 0.0 4.8 7.9 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Apc3 PF12895.2 CDF88779.1 - 0.089 12.9 0.1 1.8 8.7 0.0 2.8 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Nop10p PF04135.7 CDF88780.1 - 1.2e-21 76.1 0.1 1.5e-21 75.8 0.1 1.2 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family DASH_Dad4 PF08650.5 CDF88781.1 - 5.3e-36 122.3 6.2 5.7e-36 122.2 4.3 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 NPV_P10 PF05531.7 CDF88781.1 - 0.0035 17.5 0.5 0.0041 17.3 0.3 1.2 1 0 0 1 1 1 1 Nucleopolyhedrovirus P10 protein DUF3251 PF11622.3 CDF88781.1 - 0.034 13.5 0.4 0.034 13.5 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3251) Syntaxin_2 PF14523.1 CDF88781.1 - 0.046 13.7 1.7 0.063 13.3 1.2 1.2 1 0 0 1 1 1 0 Syntaxin-like protein Nsp1_C PF05064.8 CDF88781.1 - 0.065 12.8 0.4 0.075 12.6 0.3 1.1 1 0 0 1 1 1 0 Nsp1-like C-terminal region DASH_Dad3 PF08656.5 CDF88781.1 - 0.07 12.8 0.3 0.084 12.5 0.2 1.2 1 0 0 1 1 1 0 DASH complex subunit Dad3 Snapin_Pallidin PF14712.1 CDF88781.1 - 0.073 13.3 0.3 0.08 13.2 0.2 1.2 1 0 0 1 1 1 0 Snapin/Pallidin DUF4206 PF13901.1 CDF88781.1 - 0.078 12.5 0.1 0.084 12.4 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4206) Occludin_ELL PF07303.8 CDF88781.1 - 0.11 13.2 0.1 0.12 13.1 0.0 1.1 1 0 0 1 1 1 0 Occludin homology domain DUF972 PF06156.8 CDF88781.1 - 0.13 12.6 0.5 0.13 12.6 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF972) DASH_Dad1 PF08649.5 CDF88781.1 - 1.1 8.9 4.9 18 5.1 3.4 2.1 1 1 0 1 1 1 0 DASH complex subunit Dad1 Pkinase PF00069.20 CDF88782.1 - 2.8e-50 170.8 0.2 5.1e-50 170.0 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF88782.1 - 1.5e-23 83.1 0.0 2.5e-23 82.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF88782.1 - 4.7e-05 22.4 0.0 0.00069 18.6 0.0 2.1 1 1 1 2 2 2 1 Kinase-like Peptidase_C13 PF01650.13 CDF88783.1 - 1.1e-46 159.2 1.3 1.6e-46 158.7 0.9 1.2 1 0 0 1 1 1 1 Peptidase C13 family Thioredoxin_7 PF13899.1 CDF88784.1 - 8.2e-20 70.6 0.0 1.5e-19 69.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like UBX PF00789.15 CDF88784.1 - 6.5e-18 64.5 0.0 1.6e-17 63.3 0.0 1.7 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.1 CDF88784.1 - 1.4e-13 50.0 0.5 2.6e-13 49.2 0.3 1.5 1 0 0 1 1 1 1 UBA-like domain Thioredoxin_6 PF13848.1 CDF88784.1 - 0.011 15.5 0.1 0.018 14.8 0.1 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain C2-set PF05790.10 CDF88784.1 - 0.014 15.3 0.0 0.043 13.7 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin C2-set domain Thioredoxin_2 PF13098.1 CDF88784.1 - 0.11 12.7 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain Sas10_Utp3 PF04000.10 CDF88785.1 - 4.2e-08 33.2 4.2 4.2e-08 33.2 2.9 2.1 2 1 0 2 2 2 1 Sas10/Utp3/C1D family Rpp20 PF12328.3 CDF88785.1 - 0.022 14.4 1.1 0.022 14.4 0.8 2.2 1 1 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P ABC_tran_2 PF12848.2 CDF88785.1 - 0.14 12.0 4.2 0.37 10.6 0.0 2.4 2 0 0 2 2 2 0 ABC transporter DUF572 PF04502.8 CDF88785.1 - 0.58 9.3 13.7 0.74 8.9 9.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Peroxin-3 PF04882.7 CDF88786.1 - 7.6e-103 344.5 3.9 9.2e-103 344.2 2.7 1.1 1 0 0 1 1 1 1 Peroxin-3 Skp1 PF01466.14 CDF88787.1 - 1.8e-36 123.9 0.7 2.9e-36 123.3 0.5 1.3 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.10 CDF88787.1 - 1.6e-14 53.7 0.0 1.1e-13 51.0 0.0 2.3 2 1 0 2 2 2 1 Skp1 family, tetramerisation domain BTB PF00651.26 CDF88787.1 - 0.026 14.4 0.0 0.36 10.8 0.0 2.1 1 1 0 1 1 1 0 BTB/POZ domain DUF1743 PF08489.6 CDF88787.1 - 0.067 12.9 0.1 0.17 11.6 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1743) GRAM PF02893.15 CDF88788.1 - 8.3e-18 63.6 0.0 1.7e-17 62.6 0.0 1.6 1 0 0 1 1 1 1 GRAM domain adh_short PF00106.20 CDF88789.1 - 1e-16 61.2 0.0 1.5e-16 60.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CDF88789.1 - 7.9e-09 35.4 0.0 1.2e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CDF88789.1 - 0.00016 21.1 0.0 0.00023 20.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.1 CDF88789.1 - 0.00078 19.2 0.0 0.0011 18.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.1 CDF88789.1 - 0.011 15.7 0.0 0.16 12.0 0.0 2.1 2 0 0 2 2 2 0 NADH(P)-binding THF_DHG_CYH_C PF02882.14 CDF88789.1 - 0.055 12.5 0.0 0.12 11.4 0.0 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Swi5 PF07061.6 CDF88790.1 - 4.3e-23 80.8 1.5 4.8e-23 80.7 1.0 1.0 1 0 0 1 1 1 1 Swi5 CENP-F_leu_zip PF10473.4 CDF88790.1 - 0.0096 15.7 4.1 0.011 15.5 2.8 1.1 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 bZIP_Maf PF03131.12 CDF88790.1 - 0.013 15.7 1.0 0.02 15.1 0.7 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor Val_tRNA-synt_C PF10458.4 CDF88790.1 - 0.031 14.3 1.0 1.9 8.6 0.3 2.6 1 1 0 1 1 1 0 Valyl tRNA synthetase tRNA binding arm Tup_N PF08581.5 CDF88790.1 - 0.06 13.5 0.5 0.11 12.7 0.2 1.5 1 1 0 1 1 1 0 Tup N-terminal Lge1 PF11488.3 CDF88790.1 - 0.083 13.0 0.8 0.19 11.9 0.6 1.6 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 PEP-utilisers_N PF05524.8 CDF88790.1 - 0.1 12.3 0.4 0.12 12.1 0.3 1.2 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal DUF465 PF04325.8 CDF88790.1 - 0.27 10.9 6.7 0.71 9.6 0.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF465) Pkinase PF00069.20 CDF88791.1 - 1.6e-44 151.9 0.0 2.6e-44 151.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ribonuc_2-5A PF06479.7 CDF88791.1 - 1.6e-43 147.6 0.2 6.6e-43 145.6 0.3 1.9 2 0 0 2 2 2 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.12 CDF88791.1 - 1.3e-21 76.8 0.0 8.1e-21 74.2 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase PQQ_2 PF13360.1 CDF88791.1 - 0.0018 17.7 0.0 0.026 13.9 0.0 2.6 1 1 0 1 1 1 1 PQQ-like domain PQQ PF01011.16 CDF88791.1 - 0.0026 17.1 0.0 0.51 9.9 0.0 2.7 2 0 0 2 2 2 1 PQQ enzyme repeat Kdo PF06293.9 CDF88791.1 - 0.012 14.6 0.0 0.023 13.7 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Cnd3 PF12719.2 CDF88792.1 - 1.3e-96 323.1 5.7 2.2e-95 319.0 2.7 2.7 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.1 CDF88792.1 - 6.3e-11 42.4 0.3 3e-08 33.8 0.0 4.0 3 1 1 4 4 4 2 HEAT repeats HEAT PF02985.17 CDF88792.1 - 2.2e-08 33.4 0.8 0.52 10.5 0.0 5.6 5 0 0 5 5 5 2 HEAT repeat mRNA_triPase PF02940.10 CDF88792.1 - 0.0013 18.5 6.0 0.0023 17.6 4.2 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain HEAT_EZ PF13513.1 CDF88792.1 - 0.0035 17.7 0.1 13 6.3 0.0 4.8 4 0 0 4 4 4 1 HEAT-like repeat WD40 PF00400.27 CDF88793.1 - 1e-19 69.5 12.3 0.021 14.6 0.0 9.1 9 0 0 9 9 9 7 WD domain, G-beta repeat ABA_GPCR PF12430.3 CDF88794.1 - 8.4e-54 181.6 5.0 8.4e-54 181.6 3.5 2.3 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor DUF3735 PF12537.3 CDF88794.1 - 4.4e-17 61.8 0.5 2.8e-16 59.3 0.1 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3735) Sld5 PF05916.6 CDF88794.1 - 0.047 13.9 0.1 0.13 12.6 0.1 1.7 1 0 0 1 1 1 0 GINS complex protein FYVE PF01363.16 CDF88795.1 - 6.5e-19 67.5 25.0 1.4e-14 53.6 2.9 3.2 3 0 0 3 3 3 2 FYVE zinc finger Rbsn PF11464.3 CDF88795.1 - 1.2e-06 27.9 1.2 2.5e-06 26.9 0.9 1.6 1 0 0 1 1 1 1 Rabenosyn Rab binding domain Rad50_zn_hook PF04423.9 CDF88795.1 - 0.015 14.7 0.5 0.18 11.2 0.0 3.2 3 0 0 3 3 3 0 Rad50 zinc hook motif Prok-RING_1 PF14446.1 CDF88795.1 - 0.015 15.0 15.4 0.23 11.2 3.4 3.6 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-C2H2_4 PF13894.1 CDF88795.1 - 0.044 14.1 0.0 0.044 14.1 0.0 5.1 4 2 0 4 4 4 0 C2H2-type zinc finger zf-C2H2 PF00096.21 CDF88795.1 - 0.2 12.0 0.0 0.2 12.0 0.0 5.2 4 2 2 6 6 6 0 Zinc finger, C2H2 type MIF4G PF02854.14 CDF88796.1 - 6.7e-41 140.0 37.4 7.6e-24 84.2 2.8 4.5 4 0 0 4 4 4 3 MIF4G domain Upf2 PF04050.9 CDF88796.1 - 5.6e-15 55.5 30.9 5.6e-15 55.5 21.4 3.0 2 1 1 3 3 3 1 Up-frameshift suppressor 2 Daxx PF03344.10 CDF88796.1 - 0.1 11.1 38.0 0.22 9.9 26.3 1.5 1 0 0 1 1 1 0 Daxx Family SpoIIE PF07228.7 CDF88797.1 - 6e-36 123.9 0.0 7.9e-36 123.5 0.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.16 CDF88797.1 - 1.2e-05 24.8 0.0 0.0028 17.1 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.1 CDF88797.1 - 2.8e-05 23.6 0.3 0.0013 18.1 0.1 2.5 1 1 1 2 2 2 1 Protein phosphatase 2C PPC PF04151.10 CDF88797.1 - 0.2 12.6 2.5 0.19 12.7 0.4 2.0 2 0 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain ATP-synt_E PF05680.7 CDF88798.1 - 2.6e-14 52.9 0.0 2.8e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 ATP synthase E chain Amidinotransf PF02274.12 CDF88798.1 - 0.15 11.1 0.1 0.17 10.9 0.0 1.0 1 0 0 1 1 1 0 Amidinotransferase PBP PF01161.15 CDF88799.1 - 1.4e-11 44.4 0.1 2.4e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Peptidase_M1 PF01433.15 CDF88800.1 - 1.1e-121 406.5 0.2 3.5e-120 401.6 0.1 2.1 1 1 0 1 1 1 1 Peptidase family M1 Peptidase_MA_2 PF13485.1 CDF88800.1 - 2.7e-15 56.5 0.1 5.3e-15 55.6 0.1 1.4 1 0 0 1 1 1 1 Peptidase MA superfamily Abhydrolase_6 PF12697.2 CDF88801.1 - 2.5e-19 70.0 0.0 3.8e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDF88801.1 - 5.2e-13 49.0 0.0 9e-13 48.3 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CDF88801.1 - 4.8e-08 32.8 0.0 1e-07 31.8 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 CDF88801.1 - 5.2e-06 26.2 0.0 1.1e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Putative lysophospholipase Thioesterase PF00975.15 CDF88801.1 - 0.015 15.5 0.1 0.1 12.8 0.0 2.0 1 1 0 1 1 1 0 Thioesterase domain Lipase_3 PF01764.20 CDF88801.1 - 0.028 14.0 0.0 0.061 12.9 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) DUF2974 PF11187.3 CDF88801.1 - 0.099 11.9 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) CN_hydrolase PF00795.17 CDF88802.1 - 6.9e-25 87.4 0.0 1e-24 86.9 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.12 CDF88802.1 - 8.1e-24 83.8 0.0 2.4e-23 82.3 0.0 1.6 1 1 0 1 1 1 1 NAD synthase Asn_synthase PF00733.16 CDF88802.1 - 0.066 12.7 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase PhnG PF06754.7 CDF88802.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Phosphonate metabolism protein PhnG DIOX_N PF14226.1 CDF88803.1 - 4.6e-17 62.6 0.1 7.4e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.15 CDF88803.1 - 1.1e-13 51.2 0.0 3.3e-13 49.7 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DUF1131 PF06572.7 CDF88803.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1131) Asparaginase PF00710.15 CDF88804.1 - 2.3e-72 243.5 0.0 2.8e-72 243.2 0.0 1.0 1 0 0 1 1 1 1 Asparaginase Oxysterol_BP PF01237.13 CDF88805.1 - 1.2e-98 329.8 0.4 1.2e-98 329.8 0.3 1.7 2 0 0 2 2 2 1 Oxysterol-binding protein PH_8 PF15409.1 CDF88805.1 - 1.8e-29 101.6 0.9 5.8e-29 100.0 0.6 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.1 CDF88805.1 - 0.021 15.0 3.6 0.13 12.5 2.5 2.5 1 1 0 1 1 1 0 Pleckstrin homology domain ResIII PF04851.10 CDF88806.1 - 1.9e-27 96.3 0.0 4.8e-27 94.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.24 CDF88806.1 - 7.4e-15 54.8 0.0 1.4e-14 53.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF88806.1 - 2.5e-13 49.6 0.2 1.2e-12 47.4 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF2075 PF09848.4 CDF88806.1 - 0.00037 19.5 0.0 0.00064 18.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) SNF2_N PF00176.18 CDF88806.1 - 0.075 11.8 0.0 0.15 10.7 0.0 1.5 1 0 0 1 1 1 0 SNF2 family N-terminal domain DUF2731 PF10806.3 CDF88807.1 - 2.5e-40 137.5 0.1 1e-39 135.6 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2731) XPG_N PF00752.12 CDF88808.1 - 7e-28 96.8 0.0 1.4e-27 95.8 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.13 CDF88808.1 - 2.5e-22 78.7 0.4 8.2e-22 77.0 0.0 2.0 2 0 0 2 2 2 1 XPG I-region HHH_2 PF12826.2 CDF88808.1 - 0.00054 19.7 0.0 0.024 14.5 0.0 2.5 2 0 0 2 2 2 1 Helix-hairpin-helix motif 5_3_exonuc PF01367.15 CDF88808.1 - 0.0011 19.1 0.0 0.0035 17.5 0.0 1.9 1 1 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold XPG_I_2 PF12813.2 CDF88808.1 - 0.0069 15.9 0.0 0.017 14.6 0.0 1.6 1 0 0 1 1 1 1 XPG domain containing NeuB PF03102.9 CDF88808.1 - 0.02 14.0 0.0 0.038 13.1 0.0 1.4 1 0 0 1 1 1 0 NeuB family Ank_2 PF12796.2 CDF88809.1 - 4.2e-35 119.9 0.0 3.1e-19 69.0 0.0 2.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.25 CDF88809.1 - 4.4e-30 101.9 0.1 3.4e-07 29.7 0.0 6.1 6 0 0 6 6 6 4 Ankyrin repeat zf-DHHC PF01529.15 CDF88809.1 - 3.5e-26 91.6 2.7 8.2e-26 90.4 1.9 1.6 1 0 0 1 1 1 1 DHHC palmitoyltransferase Ank_5 PF13857.1 CDF88809.1 - 4.4e-24 83.9 0.3 1.4e-06 28.3 0.1 4.8 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.1 CDF88809.1 - 1.9e-23 82.3 0.6 8.9e-08 32.4 0.1 4.5 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDF88809.1 - 5.9e-23 78.6 0.1 9.6e-05 22.2 0.0 6.2 6 0 0 6 6 6 4 Ankyrin repeat Phage_T7_Capsid PF05396.6 CDF88809.1 - 0.12 12.4 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Phage T7 capsid assembly protein UNC45-central PF11701.3 CDF88810.1 - 1e-21 77.2 3.5 1e-21 77.2 2.5 2.2 2 0 0 2 2 2 1 Myosin-binding striated muscle assembly central LOH1CR12 PF10158.4 CDF88810.1 - 0.0036 17.0 1.6 0.018 14.8 0.1 2.8 4 0 0 4 4 4 1 Tumour suppressor protein RanGAP1_C PF07834.6 CDF88810.1 - 0.034 13.5 0.0 0.085 12.2 0.0 1.6 1 0 0 1 1 1 0 RanGAP1 C-terminal domain Pex2_Pex12 PF04757.9 CDF88811.1 - 7e-35 120.4 2.5 1.5e-34 119.4 1.7 1.4 1 1 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.1 CDF88811.1 - 1.9e-08 33.9 16.2 3e-08 33.3 11.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 CDF88811.1 - 6.8e-08 32.4 17.5 1.1e-07 31.7 12.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDF88811.1 - 3.2e-07 29.8 16.3 5.2e-07 29.2 11.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CDF88811.1 - 5.5e-07 29.1 17.7 8.2e-07 28.5 12.3 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDF88811.1 - 2.3e-05 24.0 13.3 3.9e-05 23.2 9.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 CDF88811.1 - 0.0014 18.4 16.9 0.0024 17.6 11.7 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.2 CDF88811.1 - 0.0036 17.3 13.3 0.009 16.1 9.2 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger zf-RING_UBOX PF13445.1 CDF88811.1 - 0.086 12.5 9.6 0.23 11.2 6.5 1.9 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4_3 PF13920.1 CDF88812.1 - 1.2e-08 34.5 8.1 1.2e-08 34.5 5.6 3.5 3 1 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDF88812.1 - 0.012 15.5 9.2 0.012 15.5 6.4 3.3 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Syntaxin_2 PF14523.1 CDF88813.1 - 4.6e-20 71.5 6.7 4.6e-20 71.5 4.6 2.3 2 0 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.14 CDF88813.1 - 4.2e-18 64.8 4.1 4.2e-18 64.8 2.9 2.7 2 1 0 2 2 2 1 SNARE domain DUF1212 PF06738.7 CDF88813.1 - 0.0092 15.4 0.1 0.0092 15.4 0.1 2.6 1 1 1 3 3 3 1 Protein of unknown function (DUF1212) AIF-MLS PF14962.1 CDF88813.1 - 0.075 12.6 2.8 0.11 12.1 1.9 1.2 1 0 0 1 1 1 0 Mitochondria Localisation Sequence DUF2203 PF09969.4 CDF88813.1 - 7.3 6.8 10.8 3 8.0 0.1 3.1 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) WD40 PF00400.27 CDF88814.1 - 4.6e-57 187.9 31.2 2.7e-13 49.2 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat TFIIIC_delta PF12657.2 CDF88814.1 - 0.0026 17.4 14.5 1.1 8.9 1.4 4.5 1 1 3 4 4 4 3 Transcription factor IIIC subunit delta N-term Coatomer_WDAD PF04053.9 CDF88814.1 - 0.04 12.7 6.8 0.068 11.9 0.1 2.8 2 1 1 3 3 3 0 Coatomer WD associated region IKI3 PF04762.7 CDF88814.1 - 5.7 4.6 11.7 2.7 5.6 0.9 2.8 2 1 0 3 3 3 0 IKI3 family FAD_binding_6 PF00970.19 CDF88815.1 - 4.5e-05 23.5 0.0 0.0014 18.6 0.0 2.4 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain tRNA-synt_1b PF00579.20 CDF88816.1 - 1.4e-74 250.8 0.0 1.8e-74 250.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) NCD1 PF04904.8 CDF88816.1 - 0.075 12.7 0.1 8.2 6.2 0.0 2.4 2 0 0 2 2 2 0 NAB conserved region 1 (NCD1) Hira PF07569.6 CDF88817.1 - 2.7e-84 281.7 0.5 7.5e-84 280.3 0.1 1.9 2 0 0 2 2 2 1 TUP1-like enhancer of split WD40 PF00400.27 CDF88817.1 - 2.2e-06 27.3 1.1 2.3 8.2 0.0 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat CK_II_beta PF01214.13 CDF88818.1 - 1.8e-72 242.6 0.1 2.2e-72 242.4 0.1 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit AAA-ATPase_like PF09820.4 CDF88818.1 - 0.01 14.9 0.4 0.02 14.0 0.1 1.5 1 1 1 2 2 2 0 Predicted AAA-ATPase E1-E2_ATPase PF00122.15 CDF88819.1 - 7.9e-49 165.7 0.0 1.4e-48 164.9 0.0 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 CDF88819.1 - 1.2e-35 123.8 0.0 2.4e-35 122.9 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.21 CDF88819.1 - 1.6e-30 105.0 8.2 8.1e-14 51.5 0.4 3.4 3 0 0 3 3 3 2 Heavy-metal-associated domain HAD PF12710.2 CDF88819.1 - 1.1e-13 51.7 0.0 3.9e-13 49.9 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CDF88819.1 - 1.9e-05 24.4 0.1 0.0041 16.7 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Stress-antifung PF01657.12 CDF88819.1 - 0.053 13.8 3.2 1.1 9.6 0.1 2.8 2 0 0 2 2 2 0 Salt stress response/antifungal Lactamase_B PF00753.22 CDF88820.1 - 1.3e-20 73.8 0.3 2.1e-20 73.2 0.2 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 CDF88820.1 - 5.2e-06 26.1 0.1 8.5e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 CDF88820.1 - 0.0016 18.1 0.1 0.0025 17.5 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain BcrAD_BadFG PF01869.15 CDF88820.1 - 0.026 13.7 0.0 0.051 12.8 0.0 1.4 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family CUE PF02845.11 CDF88821.1 - 5.7e-09 35.2 0.0 1e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 CUE domain TFIIB PF00382.14 CDF88823.1 - 7.9e-55 182.5 1.0 1.7e-28 98.2 0.2 2.6 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.8 CDF88823.1 - 8e-32 109.3 1.3 3.1e-31 107.4 0.9 2.1 1 0 0 1 1 1 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.7 CDF88823.1 - 9.1e-10 37.6 1.5 1.7e-09 36.8 1.0 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.18 CDF88823.1 - 2.5e-05 23.8 0.4 0.036 13.6 0.1 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain CPDase PF07823.6 CDF88824.1 - 3.3e-66 222.5 0.0 3.7e-66 222.3 0.0 1.0 1 0 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.1 CDF88824.1 - 0.00026 20.7 0.0 0.0004 20.1 0.0 1.4 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily Glucosamine_iso PF01182.15 CDF88825.1 - 7e-52 176.0 0.0 8.3e-52 175.8 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase HSF_DNA-bind PF00447.12 CDF88826.1 - 2.9e-26 91.6 0.1 4.8e-26 90.9 0.0 1.4 1 0 0 1 1 1 1 HSF-type DNA-binding RRM_1 PF00076.17 CDF88827.1 - 1.2e-31 108.1 0.1 1.8e-12 46.6 0.0 5.3 6 0 0 6 6 6 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF88827.1 - 4.6e-21 74.5 0.0 9.1e-09 35.1 0.0 4.2 3 1 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF88827.1 - 7.6e-13 48.1 0.2 0.00017 21.3 0.1 4.3 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.6 CDF88827.1 - 0.0036 17.2 0.3 2.1 8.3 0.0 3.5 4 0 0 4 4 4 2 RNA binding domain Dna2 PF08696.6 CDF88828.1 - 2.2e-64 216.6 0.2 5.1e-64 215.4 0.1 1.7 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_12 PF13087.1 CDF88828.1 - 6.7e-52 175.7 0.2 1.7e-51 174.4 0.1 1.8 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 CDF88828.1 - 4.4e-39 134.4 0.8 4.3e-19 69.0 0.0 3.6 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.1 CDF88828.1 - 1.7e-12 47.3 0.0 1.2e-10 41.3 0.0 2.8 2 1 0 2 2 2 1 AAA domain PDDEXK_1 PF12705.2 CDF88828.1 - 2.2e-10 40.3 0.0 4.1e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily AAA_19 PF13245.1 CDF88828.1 - 3.6e-08 33.0 0.1 8.5e-08 31.8 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain Viral_helicase1 PF01443.13 CDF88828.1 - 1.6e-07 31.1 0.1 0.027 13.9 0.0 3.8 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DUF911 PF06023.7 CDF88828.1 - 3.9e-05 23.0 0.1 7.8e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Archaeal protein of unknown function (DUF911) Cas_Cas4 PF01930.12 CDF88828.1 - 5.6e-05 23.1 0.0 0.00016 21.6 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function DUF83 AAA_18 PF13238.1 CDF88828.1 - 0.00048 20.4 0.2 0.031 14.5 0.0 3.2 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 CDF88828.1 - 0.0012 18.5 0.1 0.0031 17.2 0.0 1.6 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B Helicase_RecD PF05127.9 CDF88828.1 - 0.0024 17.5 0.0 0.026 14.1 0.0 2.5 2 1 0 2 2 2 1 Helicase AAA_10 PF12846.2 CDF88828.1 - 0.0024 17.3 0.4 0.0057 16.1 0.0 1.8 2 0 0 2 2 1 1 AAA-like domain AAA_16 PF13191.1 CDF88828.1 - 0.0028 17.6 0.0 0.0087 16.0 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 CDF88828.1 - 0.0037 17.3 0.1 0.037 14.1 0.0 2.8 2 1 0 2 2 1 1 AAA domain UvrD-helicase PF00580.16 CDF88828.1 - 0.0044 16.3 0.5 0.014 14.7 0.0 2.2 2 0 0 2 2 1 1 UvrD/REP helicase N-terminal domain Arch_ATPase PF01637.13 CDF88828.1 - 0.0054 16.4 0.0 0.034 13.8 0.0 2.4 2 0 0 2 2 1 1 Archaeal ATPase AAA_33 PF13671.1 CDF88828.1 - 0.0062 16.4 0.1 0.039 13.8 0.0 2.4 3 0 0 3 3 2 1 AAA domain SRP54 PF00448.17 CDF88828.1 - 0.0072 15.7 0.3 0.02 14.3 0.1 1.8 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_25 PF13481.1 CDF88828.1 - 0.011 15.2 0.0 0.027 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 CDF88828.1 - 0.016 14.9 0.0 0.041 13.5 0.0 1.7 1 0 0 1 1 1 0 NTPase AAA_14 PF13173.1 CDF88828.1 - 0.017 15.0 0.6 0.46 10.3 0.1 3.4 2 1 0 2 2 2 0 AAA domain CbiA PF01656.18 CDF88828.1 - 0.018 14.4 0.0 0.051 12.9 0.0 1.8 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain NB-ARC PF00931.17 CDF88828.1 - 0.019 13.8 0.3 0.095 11.5 0.1 2.1 2 0 0 2 2 2 0 NB-ARC domain AAA_29 PF13555.1 CDF88828.1 - 0.021 14.3 0.1 0.044 13.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain cobW PF02492.14 CDF88828.1 - 0.021 14.3 0.0 0.05 13.0 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ArgK PF03308.11 CDF88828.1 - 0.024 13.4 0.0 0.044 12.5 0.0 1.3 1 0 0 1 1 1 0 ArgK protein T2SE PF00437.15 CDF88828.1 - 0.029 13.2 0.0 0.063 12.1 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein ATP_bind_1 PF03029.12 CDF88828.1 - 0.062 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Miro PF08477.8 CDF88828.1 - 0.072 13.5 0.9 0.44 11.0 0.0 2.7 3 0 0 3 3 2 0 Miro-like protein Pox_F11 PF04943.7 CDF88829.1 - 0.0059 15.5 3.0 0.02 13.7 0.1 2.1 1 1 1 2 2 2 1 Poxvirus F11 protein Baculo_gp41 PF04700.7 CDF88829.1 - 0.0091 15.4 0.3 0.017 14.5 0.2 1.4 1 0 0 1 1 1 1 Structural glycoprotein p40/gp41 conserved region Gp37_Gp68 PF07505.6 CDF88829.1 - 0.022 13.9 0.2 0.038 13.1 0.1 1.4 1 0 0 1 1 1 0 Phage protein Gp37/Gp68 DUF3201 PF11447.3 CDF88829.1 - 0.061 12.7 1.6 0.28 10.5 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3201) PROCN PF08083.6 CDF88830.1 - 1.3e-215 715.4 12.4 2.2e-215 714.7 8.6 1.4 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.3 CDF88830.1 - 1e-122 407.8 0.9 1.8e-122 407.0 0.6 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.4 CDF88830.1 - 1.6e-87 290.8 0.4 3.3e-87 289.8 0.3 1.6 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.6 CDF88830.1 - 8.4e-77 256.0 1.8 1.9e-76 254.8 1.3 1.7 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.4 CDF88830.1 - 1.6e-64 215.5 0.0 3.3e-64 214.5 0.0 1.5 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.4 CDF88830.1 - 1e-42 143.8 0.3 2.3e-42 142.7 0.2 1.6 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.6 CDF88830.1 - 3.8e-42 142.9 0.0 8.4e-42 141.8 0.0 1.6 1 0 0 1 1 1 1 PROCT (NUC072) domain APC8 PF04049.8 CDF88831.1 - 2.5e-36 124.5 0.2 6.6e-36 123.1 0.1 1.7 1 0 0 1 1 1 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.23 CDF88831.1 - 1.2e-20 72.1 20.7 3.4e-06 26.4 0.5 7.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.1 CDF88831.1 - 7.7e-20 70.3 17.2 1.5e-08 34.1 0.1 5.9 3 1 4 7 7 7 4 TPR repeat TPR_2 PF07719.12 CDF88831.1 - 1.9e-16 58.5 22.5 5.6e-06 25.8 0.7 8.5 8 1 1 9 9 9 4 Tetratricopeptide repeat TPR_8 PF13181.1 CDF88831.1 - 2.6e-15 54.9 20.2 0.0025 17.4 0.2 8.8 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_12 PF13424.1 CDF88831.1 - 8e-15 54.5 15.7 0.0019 18.0 0.2 5.8 2 1 3 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.1 CDF88831.1 - 4.6e-11 42.3 6.4 0.0024 18.3 0.8 5.5 5 2 2 7 7 5 3 Tetratricopeptide repeat TPR_16 PF13432.1 CDF88831.1 - 1.3e-10 41.6 4.5 0.00047 20.7 0.0 4.6 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_7 PF13176.1 CDF88831.1 - 1.4e-09 37.0 6.9 2.8e-05 23.5 0.2 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.1 CDF88831.1 - 1e-05 25.3 11.1 0.023 14.8 0.0 6.0 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.1 CDF88831.1 - 1e-05 25.7 3.5 0.17 12.2 0.1 4.8 4 1 1 5 5 5 2 Tetratricopeptide repeat RPN7 PF10602.4 CDF88831.1 - 2.6e-05 23.6 1.1 6.2e-05 22.4 0.3 1.9 2 0 0 2 2 2 1 26S proteasome subunit RPN7 ChAPs PF09295.5 CDF88831.1 - 3.2e-05 22.9 0.2 0.0065 15.2 0.0 2.2 1 1 1 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_15 PF13429.1 CDF88831.1 - 0.00016 20.8 2.7 0.076 12.0 0.1 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat Apc3 PF12895.2 CDF88831.1 - 0.00026 21.0 22.1 0.12 12.4 3.1 5.3 3 1 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.12 CDF88831.1 - 0.00059 20.1 0.9 0.0016 18.7 0.4 1.8 1 1 0 1 1 1 1 Bacterial transcriptional activator domain TPR_9 PF13371.1 CDF88831.1 - 0.00069 19.4 2.9 0.043 13.6 0.9 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.1 CDF88831.1 - 0.0018 18.1 6.1 1.4 8.9 0.0 4.0 3 1 1 4 4 4 2 Tetratricopeptide repeat MIT PF04212.13 CDF88831.1 - 0.032 14.0 3.0 7.6 6.4 0.2 3.3 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain NSF PF02071.15 CDF88831.1 - 1.3 9.8 4.6 38 5.5 0.1 4.1 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat TPR_6 PF13174.1 CDF88831.1 - 1.6 9.3 14.3 3.6 8.2 0.4 6.7 8 1 0 8 8 7 0 Tetratricopeptide repeat THP2 PF09432.5 CDF88832.1 - 3.6e-46 156.2 6.3 3.6e-46 156.2 4.4 1.8 2 0 0 2 2 2 1 Tho complex subunit THP2 DUF2310 PF10071.4 CDF88832.1 - 0.037 12.9 0.3 0.037 12.9 0.2 2.1 2 1 0 2 2 2 0 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310) ISG65-75 PF11727.3 CDF88832.1 - 0.049 12.6 2.3 0.12 11.3 0.1 2.0 2 0 0 2 2 2 0 Invariant surface glycoprotein CHASE3 PF05227.8 CDF88832.1 - 0.32 10.6 4.7 0.53 9.9 0.2 2.8 1 1 2 3 3 3 0 CHASE3 domain DUF342 PF03961.8 CDF88832.1 - 2.1 6.6 7.7 0.58 8.5 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF342) UBN2_2 PF14227.1 CDF88832.1 - 3.7 7.1 10.3 0.15 11.6 0.8 2.9 2 1 2 4 4 4 0 gag-polypeptide of LTR copia-type GTP1_OBG PF01018.17 CDF88833.1 - 5e-32 110.7 2.4 4.1e-23 81.7 0.9 2.2 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.18 CDF88833.1 - 3.7e-21 75.2 0.0 6.5e-21 74.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 CDF88833.1 - 7.8e-10 38.2 0.0 1.3e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.16 CDF88833.1 - 1e-08 34.6 0.0 2.2e-08 33.5 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 CDF88833.1 - 8.9e-06 26.1 0.0 2e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 CDF88833.1 - 4.2e-05 23.0 0.2 0.0068 15.8 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain SRPRB PF09439.5 CDF88833.1 - 0.00058 19.1 0.0 0.0011 18.2 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 CDF88833.1 - 0.0022 17.4 0.0 0.0063 15.9 0.0 1.8 1 1 0 1 1 1 1 Ras family Dynamin_N PF00350.18 CDF88833.1 - 0.025 14.4 0.0 6 6.6 0.0 2.4 1 1 1 2 2 2 0 Dynamin family DEAD PF00270.24 CDF88834.1 - 5e-40 136.7 0.1 1.1e-37 129.0 0.0 2.1 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF88834.1 - 1.7e-26 91.9 0.1 3.2e-26 90.9 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDF88834.1 - 0.0035 17.1 0.0 0.011 15.6 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2702 PF10863.3 CDF88835.1 - 9.4e-43 145.3 6.1 9.4e-43 145.3 4.2 1.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2702) HR1 PF02185.11 CDF88835.1 - 0.34 10.6 4.5 0.38 10.5 0.6 2.6 3 0 0 3 3 3 0 Hr1 repeat Uds1 PF15456.1 CDF88835.1 - 6.6 6.7 9.8 0.5 10.3 0.3 2.5 2 1 0 2 2 2 0 Up-regulated During Septation NMD3 PF04981.8 CDF88836.1 - 1.6e-75 253.2 3.1 2.7e-75 252.5 2.1 1.4 1 0 0 1 1 1 1 NMD3 family Ribonuclease_3 PF00636.21 CDF88836.1 - 0.11 12.9 0.1 0.27 11.7 0.1 1.6 1 0 0 1 1 1 0 Ribonuclease III domain ThiF PF00899.16 CDF88837.1 - 1.8e-28 99.0 0.0 3.9e-28 97.9 0.0 1.6 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.15 CDF88837.1 - 0.002 18.2 0.0 0.016 15.2 0.0 2.1 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.11 CDF88837.1 - 0.043 13.2 0.0 0.072 12.5 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Bromodomain PF00439.20 CDF88838.1 - 2.8e-26 91.2 2.2 5.6e-26 90.2 1.5 1.5 1 0 0 1 1 1 1 Bromodomain Acetyltransf_7 PF13508.1 CDF88838.1 - 2.2e-08 34.1 0.4 5.7e-08 32.8 0.3 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CDF88838.1 - 2.6e-08 33.7 0.1 5.2e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 CDF88838.1 - 0.0033 17.5 0.0 0.0065 16.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 CDF88838.1 - 0.059 13.1 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Proteasome PF00227.21 CDF88839.1 - 1.4e-53 180.9 0.0 1.9e-53 180.6 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 CDF88839.1 - 1.3e-13 49.9 0.1 3.9e-13 48.4 0.1 1.9 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Spc97_Spc98 PF04130.8 CDF88840.1 - 8.9e-68 228.9 14.2 1.2e-67 228.5 9.9 1.2 1 0 0 1 1 1 1 Spc97 / Spc98 family Enolase_C PF00113.17 CDF88841.1 - 2.8e-149 495.9 0.0 3.9e-149 495.4 0.0 1.2 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.11 CDF88841.1 - 3.5e-56 188.7 0.2 6.3e-56 187.9 0.2 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.1 CDF88841.1 - 0.013 15.4 0.0 0.055 13.4 0.0 2.0 2 0 0 2 2 2 0 Enolase C-terminal domain-like MAAL_C PF07476.6 CDF88841.1 - 0.026 13.4 0.1 0.053 12.4 0.0 1.5 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus MR_MLE PF01188.16 CDF88841.1 - 0.069 13.6 0.0 0.18 12.3 0.0 1.8 1 0 0 1 1 1 0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain Ctr PF04145.10 CDF88842.1 - 7.1e-29 100.7 11.6 2.9e-14 53.3 4.4 2.1 1 1 1 2 2 2 2 Ctr copper transporter family STE2 PF02116.10 CDF88842.1 - 0.0074 15.3 0.4 0.41 9.6 0.0 2.0 1 1 1 2 2 2 2 Fungal pheromone mating factor STE2 GPCR DUF2897 PF11446.3 CDF88842.1 - 0.026 14.3 2.3 0.042 13.6 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2897) Abi PF02517.11 CDF88842.1 - 0.06 13.4 2.2 0.77 9.9 0.1 2.1 2 0 0 2 2 2 0 CAAX protease self-immunity DUF3021 PF11457.3 CDF88842.1 - 0.99 9.2 6.2 9 6.1 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3021) FMO-like PF00743.14 CDF88843.1 - 3.7e-41 140.9 0.1 1.1e-27 96.4 0.0 2.0 1 1 1 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.1 CDF88843.1 - 9.4e-16 58.4 0.1 1.8e-15 57.5 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CDF88843.1 - 6.2e-15 55.3 0.1 7.6e-14 51.7 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.9 CDF88843.1 - 5.9e-12 45.8 0.0 9.6e-12 45.1 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 CDF88843.1 - 1.1e-09 37.6 1.2 3.7e-07 29.3 0.2 3.2 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 CDF88843.1 - 3.4e-06 26.9 0.0 2e-05 24.5 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CDF88843.1 - 7e-06 25.1 0.0 0.1 11.4 0.0 2.6 2 1 0 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.12 CDF88843.1 - 8.2e-05 21.8 0.0 0.00035 19.7 0.0 1.9 2 0 0 2 2 2 1 Thi4 family Mqo PF06039.10 CDF88843.1 - 0.01 14.0 0.1 0.017 13.3 0.1 1.2 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) Pyr_redox PF00070.22 CDF88843.1 - 0.022 15.1 0.5 18 5.8 0.0 3.3 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CDF88843.1 - 0.047 12.1 0.1 0.26 9.7 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein Fungal_trans PF04082.13 CDF88844.1 - 4.9e-27 94.4 0.0 7.2e-27 93.8 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF88844.1 - 3.3e-07 30.0 13.6 6e-07 29.2 9.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BBIP10 PF14777.1 CDF88844.1 - 0.079 12.3 3.3 0.047 13.0 0.5 1.9 2 0 0 2 2 2 0 Cilia BBSome complex subunit 10 Dickkopf_N PF04706.7 CDF88844.1 - 7.7 6.7 14.0 2.2 8.4 7.1 2.1 2 0 0 2 2 2 0 Dickkopf N-terminal cysteine-rich region Oxidored_FMN PF00724.15 CDF88845.1 - 1.1e-117 392.8 0.0 1.3e-117 392.6 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family ComX PF05952.7 CDF88845.1 - 0.049 13.1 0.0 7.3 6.1 0.0 2.5 2 0 0 2 2 2 0 Bacillus competence pheromone ComX Oxidored_FMN PF00724.15 CDF88846.1 - 1e-100 337.0 0.0 1.3e-100 336.7 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Ribosom_S12_S23 PF00164.20 CDF88847.1 - 9.8e-43 144.4 1.4 1.2e-42 144.1 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Ribosomal_S19 PF00203.16 CDF88848.1 - 3.4e-22 77.8 0.0 4.5e-22 77.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Med12 PF09497.5 CDF88849.1 - 2.1e-23 82.0 0.3 4.9e-23 80.8 0.2 1.7 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 Cation_efflux PF01545.16 CDF88850.1 - 2.8e-06 26.5 14.8 1.2e-05 24.5 9.5 2.4 2 1 1 3 3 3 1 Cation efflux family Pkinase PF00069.20 CDF88851.1 - 1.5e-44 152.0 0.0 2.2e-44 151.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF88851.1 - 2.9e-27 95.3 0.0 4.9e-27 94.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF88851.1 - 0.013 14.4 0.0 0.43 9.4 0.0 2.4 2 0 0 2 2 2 0 Kinase-like APH PF01636.18 CDF88851.1 - 0.023 14.4 0.2 0.22 11.2 0.1 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Ribosomal_L39 PF00832.15 CDF88852.1 - 5.7e-21 73.7 9.0 6.5e-21 73.5 6.2 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein Ivy PF08816.6 CDF88852.1 - 0.063 13.2 0.3 0.063 13.2 0.2 1.1 1 0 0 1 1 1 0 Inhibitor of vertebrate lysozyme (Ivy) Ribosomal_S8 PF00410.14 CDF88853.1 - 1e-26 93.2 0.1 1.4e-26 92.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 Ribosomal_S11 PF00411.14 CDF88854.1 - 1.9e-40 137.4 1.0 2.3e-40 137.1 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 DUF814 PF05670.8 CDF88854.1 - 0.11 12.3 0.0 0.16 11.8 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF814) Beach PF02138.13 CDF88856.1 - 1.7e-107 358.8 0.2 3e-107 358.0 0.1 1.4 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.1 CDF88856.1 - 2.4e-12 46.6 0.0 7.6e-12 45.0 0.0 1.8 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.27 CDF88856.1 - 0.00073 19.3 0.2 0.033 14.0 0.0 2.9 2 0 0 2 2 2 1 WD domain, G-beta repeat Laminin_G_3 PF13385.1 CDF88856.1 - 0.12 12.6 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily TPT PF03151.11 CDF88857.1 - 1.2e-33 115.9 7.1 1.2e-33 115.9 4.9 2.8 2 1 1 3 3 3 1 Triose-phosphate Transporter family EamA PF00892.15 CDF88857.1 - 0.00054 19.9 25.1 0.002 18.1 0.7 3.7 3 1 1 4 4 4 2 EamA-like transporter family UAA PF08449.6 CDF88857.1 - 0.0044 15.9 17.7 0.037 12.9 12.3 2.3 1 1 0 1 1 1 1 UAA transporter family EmrE PF13536.1 CDF88857.1 - 0.039 14.1 0.3 0.039 14.1 0.2 3.8 4 2 1 5 5 5 0 Multidrug resistance efflux transporter Nuc_sug_transp PF04142.10 CDF88857.1 - 0.29 10.1 6.8 0.89 8.5 0.7 3.0 3 0 0 3 3 3 0 Nucleotide-sugar transporter AAA_16 PF13191.1 CDF88858.1 - 3.3e-09 36.9 0.0 4e-08 33.4 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain AAA PF00004.24 CDF88858.1 - 1e-08 35.4 0.0 4e-08 33.5 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CDF88858.1 - 5.6e-08 32.9 0.0 2.6e-07 30.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain Cdc6_C PF09079.6 CDF88858.1 - 6e-07 29.1 0.2 2.1e-06 27.3 0.0 2.0 2 0 0 2 2 2 1 CDC6, C terminal AAA_19 PF13245.1 CDF88858.1 - 3.1e-06 26.8 0.3 9.3e-05 22.1 0.1 2.6 2 0 0 2 2 2 1 Part of AAA domain AAA_11 PF13086.1 CDF88858.1 - 0.0034 17.0 0.4 0.35 10.4 0.0 2.7 3 1 0 3 3 3 1 AAA domain AAA_14 PF13173.1 CDF88858.1 - 0.062 13.1 0.0 18 5.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 CDF88858.1 - 0.087 12.9 0.2 4.1 7.6 0.0 2.8 3 0 0 3 3 3 0 RNA helicase Myb_DNA-binding PF00249.26 CDF88859.1 - 7e-17 61.2 0.0 8.4e-08 32.1 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CDF88859.1 - 0.00021 21.2 6.6 0.017 15.2 0.1 3.5 3 0 0 3 3 3 2 Myb-like DNA-binding domain Lipoprotein_20 PF13942.1 CDF88860.1 - 0.0035 16.8 9.2 0.24 10.9 0.1 2.6 2 0 0 2 2 2 2 YfhG lipoprotein UB2H PF14814.1 CDF88860.1 - 0.008 15.8 1.9 0.026 14.2 1.3 1.9 1 0 0 1 1 1 1 Bifunctional transglycosylase second domain DUF1664 PF07889.7 CDF88860.1 - 0.31 10.8 15.3 0.13 12.0 2.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Syntaxin-6_N PF09177.6 CDF88860.1 - 1.2 9.5 12.7 1.5 9.2 0.8 3.1 2 1 0 2 2 2 0 Syntaxin 6, N-terminal CENP-F_leu_zip PF10473.4 CDF88860.1 - 2.2 8.1 33.8 0.21 11.4 6.3 3.0 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Nrap PF03813.9 CDF88861.1 - 0 1197.6 6.2 0 1197.3 4.3 1.0 1 0 0 1 1 1 1 Nrap protein DUF1746 PF08508.5 CDF88862.1 - 0.0077 16.1 2.5 0.27 11.1 0.4 3.0 1 1 1 2 2 2 1 Fungal domain of unknown function (DUF1746) RNA_pol_A_bac PF01000.21 CDF88863.1 - 1.9e-29 102.0 0.0 3.9e-29 101.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 CDF88863.1 - 3.3e-15 54.9 0.0 4.4e-15 54.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Nop PF01798.13 CDF88864.1 - 1.3e-40 138.1 0.4 2.1e-40 137.4 0.3 1.3 1 0 0 1 1 1 1 Putative snoRNA binding domain Prp31_C PF09785.4 CDF88864.1 - 4.6e-26 91.6 8.8 1e-25 90.5 6.1 1.6 1 0 0 1 1 1 1 Prp31 C terminal domain NOSIC PF08060.8 CDF88864.1 - 2.4e-06 27.2 0.0 6.7e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 NOSIC (NUC001) domain Borrelia_lipo_2 PF06238.6 CDF88864.1 - 0.11 12.5 0.2 0.24 11.4 0.2 1.5 1 0 0 1 1 1 0 Borrelia burgdorferi BBR25 lipoprotein Pkinase PF00069.20 CDF88865.1 - 1.4e-52 178.4 0.1 1.8e-51 174.8 0.1 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF88865.1 - 2.4e-28 98.9 0.2 7e-20 71.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.19 CDF88865.1 - 1.2e-05 25.6 0.7 1.2e-05 25.6 0.5 2.5 2 1 1 3 3 3 1 Protein kinase C terminal domain Kinase-like PF14531.1 CDF88865.1 - 0.00065 18.7 0.1 0.01 14.8 0.0 2.2 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.9 CDF88865.1 - 0.028 13.4 0.0 0.05 12.6 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CDF88865.1 - 0.069 12.8 0.0 0.3 10.7 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family CwfJ_C_1 PF04677.10 CDF88866.1 - 1.2e-30 105.6 0.5 2.5e-30 104.6 0.3 1.5 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.9 CDF88866.1 - 1.6e-17 63.7 0.4 3.6e-17 62.6 0.3 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 RRM_1 PF00076.17 CDF88867.1 - 7.3e-71 233.7 10.1 2e-17 62.5 0.0 6.4 6 0 0 6 6 6 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF88867.1 - 9.7e-64 211.2 1.6 1.7e-15 56.7 0.0 5.5 5 0 0 5 5 5 5 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF88867.1 - 6.1e-38 128.4 0.0 2e-09 37.1 0.0 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CDF88867.1 - 0.005 16.5 0.0 18 5.1 0.0 4.5 5 0 0 5 5 5 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.3 CDF88867.1 - 0.082 12.6 0.9 2.4 7.9 0.0 3.8 4 1 1 5 5 5 0 Limkain b1 tRNA-synt_1 PF00133.17 CDF88868.1 - 3.5e-233 775.0 0.2 2e-232 772.5 0.2 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 CDF88868.1 - 4.1e-32 111.0 1.6 1.6e-31 109.0 1.1 2.1 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 CDF88868.1 - 5.3e-19 68.1 0.1 9.2e-09 34.4 0.0 4.5 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.1 CDF88868.1 - 7.6e-10 38.3 11.1 4.9e-08 32.4 0.0 3.5 3 1 1 4 4 4 2 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.4 CDF88868.1 - 9.8e-06 25.5 5.5 9.8e-06 25.5 3.8 3.1 2 0 0 2 2 2 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1e PF01406.14 CDF88868.1 - 0.0027 16.8 0.0 0.31 10.1 0.0 3.1 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain RNase_PH PF01138.16 CDF88869.1 - 6.6e-20 71.7 0.0 1e-19 71.1 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 CDF88869.1 - 1.9e-08 34.1 0.3 1.1e-06 28.4 0.0 2.3 2 0 0 2 2 2 2 3' exoribonuclease family, domain 2 Mito_carr PF00153.22 CDF88870.1 - 7.2e-58 192.3 3.3 2.4e-21 75.2 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein CDP-OH_P_transf PF01066.16 CDF88871.1 - 4.7e-19 68.5 4.2 4.7e-19 68.5 2.9 1.7 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase TRAM_LAG1_CLN8 PF03798.11 CDF88872.1 - 3.8e-33 114.7 20.6 6.1e-33 114.0 14.3 1.3 1 0 0 1 1 1 1 TLC domain PH PF00169.24 CDF88873.1 - 3.6e-20 72.1 0.2 7.9e-20 71.0 0.2 1.6 1 0 0 1 1 1 1 PH domain Selenoprotein_S PF06936.6 CDF88873.1 - 0.057 12.9 4.0 0.2 11.2 2.8 1.9 1 0 0 1 1 1 0 Selenoprotein S (SelS) Flavin_Reduct PF01613.13 CDF88874.1 - 1.8e-30 105.8 0.0 2.1e-30 105.5 0.0 1.0 1 0 0 1 1 1 1 Flavin reductase like domain DNA_pol_B PF00136.16 CDF88875.1 - 0.034 12.9 0.3 0.043 12.5 0.2 1.2 1 0 0 1 1 1 0 DNA polymerase family B Peptidase_C50 PF03568.12 CDF88876.1 - 8.9e-116 386.7 1.2 1.3e-115 386.1 0.0 1.9 2 0 0 2 2 2 1 Peptidase family C50 Telomere_reg-2 PF10193.4 CDF88877.1 - 1.1e-23 83.6 0.4 1.1e-23 83.6 0.3 2.9 2 1 0 2 2 2 1 Telomere length regulation protein Fmp27_WPPW PF10359.4 CDF88878.1 - 1.1e-117 393.3 0.4 2e-117 392.5 0.3 1.4 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Apt1 PF10351.4 CDF88878.1 - 9.6e-100 334.5 1.2 2e-99 333.5 0.1 1.9 2 0 0 2 2 2 1 Golgi-body localisation protein domain Fmp27_GFWDK PF10347.4 CDF88878.1 - 7.7e-46 155.8 0.0 2.3e-45 154.2 0.0 1.9 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.4 CDF88878.1 - 5e-41 140.0 1.7 2e-40 138.1 1.2 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.4 CDF88878.1 - 9.6e-21 74.1 0.1 4.1e-19 68.9 0.0 3.4 3 0 0 3 3 3 1 RNA pol II promoter Fmp27 protein domain Rootletin PF15035.1 CDF88878.1 - 0.031 14.2 2.6 0.1 12.5 1.8 1.9 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion RabGAP-TBC PF00566.13 CDF88879.1 - 1.2e-54 184.9 0.6 3.5e-54 183.5 0.4 1.8 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.15 CDF88879.1 - 1.6e-13 49.9 0.1 5e-13 48.3 0.0 1.9 1 0 0 1 1 1 1 GRAM domain EF-hand_6 PF13405.1 CDF88879.1 - 6.3e-07 28.7 0.7 0.003 17.3 0.0 3.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.1 CDF88879.1 - 1.6e-06 28.1 0.3 1.6e-05 24.9 0.3 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 CDF88879.1 - 0.00092 18.3 0.2 0.067 12.5 0.0 3.0 2 0 0 2 2 2 1 EF hand Death PF00531.17 CDF88879.1 - 0.075 12.8 0.0 1.1 9.1 0.0 2.5 2 0 0 2 2 2 0 Death domain Rhomboid PF01694.17 CDF88880.1 - 5.3e-29 101.1 17.3 5.3e-29 101.1 12.0 1.7 2 0 0 2 2 2 1 Rhomboid family Pescadillo_N PF06732.6 CDF88882.1 - 1.2e-122 408.5 1.8 1.2e-122 408.5 1.3 2.3 2 1 1 3 3 3 1 Pescadillo N-terminus BRCT PF00533.21 CDF88882.1 - 1.5e-09 37.8 0.0 6e-09 35.9 0.0 2.1 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Med18 PF09637.5 CDF88883.1 - 5.5e-62 209.5 0.1 6.2e-62 209.3 0.1 1.0 1 0 0 1 1 1 1 Med18 protein VMA21 PF09446.5 CDF88884.1 - 2.8e-16 59.1 7.6 3.4e-16 58.9 5.2 1.1 1 0 0 1 1 1 1 VMA21-like domain MscS_TM PF12794.2 CDF88884.1 - 0.042 12.4 0.2 0.042 12.4 0.1 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF2663 PF10864.3 CDF88884.1 - 0.048 13.8 0.4 0.053 13.7 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2663) DIE2_ALG10 PF04922.7 CDF88884.1 - 0.06 12.3 2.2 0.083 11.9 1.5 1.3 1 1 0 1 1 1 0 DIE2/ALG10 family DUF3917 PF13055.1 CDF88884.1 - 0.13 12.5 1.5 0.2 11.9 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3917) DUF1385 PF07136.6 CDF88884.1 - 0.15 11.1 1.4 0.17 10.8 1.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1385) VKOR PF07884.9 CDF88884.1 - 0.15 11.8 1.8 0.19 11.5 1.3 1.0 1 0 0 1 1 1 0 Vitamin K epoxide reductase family ATP-synt_S1 PF05827.7 CDF88885.1 - 0.00035 19.9 0.0 0.00041 19.7 0.0 1.4 1 1 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) IF-2B PF01008.12 CDF88886.1 - 3.5e-80 268.9 0.0 4.2e-80 268.7 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family SIS PF01380.17 CDF88889.1 - 4.6e-10 39.2 0.0 7.7e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 SIS domain SIS_2 PF13580.1 CDF88889.1 - 7.3e-07 28.9 0.1 0.00018 21.2 0.2 2.3 1 1 1 2 2 2 2 SIS domain DUF946 PF06101.6 CDF88891.1 - 1.3e-07 30.0 1.3 6.8e-07 27.6 0.5 2.1 2 0 0 2 2 2 2 Plant protein of unknown function (DUF946) GCR1_C PF12550.3 CDF88892.1 - 1.5e-14 53.6 0.0 3.3e-14 52.4 0.0 1.7 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Utp14 PF04615.8 CDF88892.1 - 2.3 6.2 6.2 3.1 5.8 4.3 1.1 1 0 0 1 1 1 0 Utp14 protein MFS_1 PF07690.11 CDF88893.1 - 6.2e-32 110.6 34.1 6.2e-32 110.6 23.6 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CDF88893.1 - 3.7e-12 45.5 28.6 6.7e-12 44.7 19.6 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter LIP PF03583.9 CDF88894.1 - 0.075 12.2 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 Secretory lipase Utp11 PF03998.8 CDF88898.1 - 9.6e-74 248.2 33.4 1.1e-73 248.0 23.2 1.0 1 0 0 1 1 1 1 Utp11 protein Peptidase_A22B PF04258.8 CDF88899.1 - 1.9e-38 132.6 5.4 4.8e-38 131.2 3.7 1.7 1 1 0 1 1 1 1 Signal peptide peptidase RRM_1 PF00076.17 CDF88900.1 - 1.4e-14 53.4 0.0 2.2e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF88900.1 - 1.6e-13 50.3 0.0 2.5e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF88900.1 - 2.3e-09 36.9 0.0 4.1e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Homeobox_KN PF05920.6 CDF88901.1 - 2.5e-17 62.3 1.3 4.9e-17 61.3 0.9 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeobox PF00046.24 CDF88901.1 - 1e-05 25.0 0.3 2.8e-05 23.6 0.2 1.7 1 0 0 1 1 1 1 Homeobox domain Arrestin_N PF00339.24 CDF88902.1 - 0.027 14.2 0.3 0.12 12.1 0.2 2.2 1 1 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain Collagen PF01391.13 CDF88902.1 - 0.61 9.6 6.1 1.1 8.8 4.2 1.3 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) DAHP_synth_1 PF00793.15 CDF88903.1 - 1.9e-100 335.0 0.0 2.4e-100 334.7 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family His_biosynth PF00977.16 CDF88904.1 - 2.7e-45 154.4 0.2 1.5e-44 152.0 0.1 2.2 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.23 CDF88904.1 - 5.8e-26 91.1 0.0 1.2e-25 90.0 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferase class-I GATase_3 PF07685.9 CDF88904.1 - 3.1e-08 33.3 0.0 8e-08 32.0 0.0 1.6 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.14 CDF88904.1 - 5.9e-08 32.5 0.0 0.00024 20.8 0.0 2.2 2 0 0 2 2 2 2 SNO glutamine amidotransferase family Peptidase_C26 PF07722.8 CDF88904.1 - 0.0053 16.2 0.0 0.18 11.1 0.0 2.2 2 0 0 2 2 2 1 Peptidase C26 RCC1 PF00415.13 CDF88905.1 - 7.9e-60 198.8 0.3 1.2e-12 47.8 0.0 7.9 7 2 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 CDF88905.1 - 3.4e-35 118.8 15.4 3.1e-08 33.0 0.0 7.1 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat CBM_X PF06204.6 CDF88905.1 - 0.034 13.6 0.3 36 3.9 0.0 3.4 3 0 0 3 3 3 0 Putative carbohydrate binding domain BLOC1_2 PF10046.4 CDF88906.1 - 0.044 13.9 4.7 0.26 11.4 1.4 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.7 CDF88906.1 - 0.22 11.7 5.6 6.6 7.0 0.7 2.4 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Bystin PF05291.6 CDF88907.1 - 5.8e-123 409.6 0.0 1.1e-122 408.7 0.0 1.4 1 0 0 1 1 1 1 Bystin SecD_SecF PF02355.11 CDF88907.1 - 0.2 10.8 0.0 0.39 9.8 0.0 1.4 1 0 0 1 1 1 0 Protein export membrane protein DUF1501 PF07394.7 CDF88907.1 - 0.55 8.9 3.4 5.1 5.8 2.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1501) MFS_1 PF07690.11 CDF88908.1 - 9e-31 106.8 30.2 9e-31 106.8 21.0 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1 PF07690.11 CDF88909.1 - 5.8e-31 107.4 31.4 2.8e-30 105.2 21.8 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CDF88909.1 - 2.3e-12 46.2 4.9 2.3e-12 46.2 3.4 2.9 2 2 1 3 3 3 1 Sugar (and other) transporter SecE PF00584.15 CDF88909.1 - 0.029 13.9 0.1 1.9 8.0 0.0 3.1 2 0 0 2 2 2 0 SecE/Sec61-gamma subunits of protein translocation complex Use1 PF09753.4 CDF88910.1 - 1.2e-09 37.9 0.6 2.1e-09 37.1 0.4 1.5 1 1 0 1 1 1 1 Membrane fusion protein Use1 Tyr-DNA_phospho PF06087.7 CDF88910.1 - 0.02 13.5 0.0 0.025 13.2 0.0 1.2 1 0 0 1 1 1 0 Tyrosyl-DNA phosphodiesterase DUF1934 PF09148.5 CDF88910.1 - 0.052 13.2 0.4 3.9 7.1 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF1934) Orbi_NS3 PF01616.11 CDF88910.1 - 0.14 11.1 0.0 0.22 10.4 0.0 1.3 1 0 0 1 1 1 0 Orbivirus NS3 NPCC PF08058.6 CDF88910.1 - 0.37 10.6 1.7 5.5 6.8 0.2 2.2 2 0 0 2 2 2 0 Nuclear pore complex component MMR_HSR1 PF01926.18 CDF88911.1 - 4.1e-16 58.9 0.4 1.9e-14 53.5 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 CDF88911.1 - 1.3e-07 31.0 0.5 1.9e-05 23.9 0.1 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B DUF258 PF03193.11 CDF88911.1 - 0.00086 18.5 0.0 0.0019 17.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AIG1 PF04548.11 CDF88911.1 - 0.0077 15.3 0.1 0.017 14.2 0.1 1.5 1 0 0 1 1 1 1 AIG1 family Miro PF08477.8 CDF88911.1 - 0.04 14.3 0.1 0.13 12.7 0.0 1.9 1 0 0 1 1 1 0 Miro-like protein Dynamin_N PF00350.18 CDF88911.1 - 1.2 8.8 9.1 0.27 11.0 1.6 3.3 3 1 0 3 3 3 0 Dynamin family WD40 PF00400.27 CDF88912.1 - 3.9e-08 32.8 5.1 0.88 9.5 0.3 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat SNF2_N PF00176.18 CDF88913.1 - 2.8e-80 269.2 2.0 5.2e-80 268.4 1.4 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.5 CDF88913.1 - 2.5e-40 136.8 2.9 2.5e-40 136.8 2.0 3.2 3 1 0 3 3 3 1 SLIDE HAND PF09110.6 CDF88913.1 - 1.6e-30 105.8 1.9 1.6e-30 105.8 1.3 4.9 6 0 0 6 6 6 1 HAND Helicase_C PF00271.26 CDF88913.1 - 8.9e-16 57.5 0.0 1.1e-14 54.0 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDF88913.1 - 2.2e-07 30.9 0.0 2.2e-07 30.9 0.0 4.6 4 1 0 4 4 4 1 Type III restriction enzyme, res subunit DEAD PF00270.24 CDF88913.1 - 6.3e-05 22.5 0.0 0.00016 21.2 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_14 PF13173.1 CDF88913.1 - 0.0025 17.7 0.4 0.03 14.2 0.1 2.9 2 0 0 2 2 2 1 AAA domain DEAD_2 PF06733.10 CDF88913.1 - 0.0037 16.6 0.1 0.0099 15.2 0.1 1.7 1 0 0 1 1 1 1 DEAD_2 NDUF_B5 PF09781.4 CDF88913.1 - 0.12 11.6 4.1 0.046 13.0 0.4 2.0 2 0 0 2 2 2 0 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit GSHPx PF00255.14 CDF88914.1 - 1.7e-46 155.9 0.2 2.3e-46 155.5 0.1 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.16 CDF88914.1 - 5e-06 26.2 0.2 1.6e-05 24.5 0.1 1.8 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 CDF88914.1 - 7.7e-05 22.2 0.1 0.00015 21.3 0.1 1.6 1 1 0 1 1 1 1 Redoxin SelP_N PF04592.9 CDF88914.1 - 0.071 12.4 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region WD40 PF00400.27 CDF88915.1 - 4.1e-36 121.5 21.9 1.6e-09 37.2 0.1 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat DUF2237 PF09996.4 CDF88915.1 - 0.06 12.8 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2237) Glycos_transf_4 PF00953.16 CDF88916.1 - 1.6e-29 102.7 12.3 1.6e-29 102.7 8.5 2.2 2 1 0 2 2 2 1 Glycosyl transferase family 4 HD_3 PF13023.1 CDF88917.1 - 2.4e-35 121.7 0.2 3e-35 121.3 0.2 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.17 CDF88917.1 - 2.2e-07 30.8 0.0 4.4e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 HD domain Ribosomal_L18e PF00828.14 CDF88918.1 - 2.4e-32 111.9 0.2 3e-32 111.7 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 Sugar_tr PF00083.19 CDF88919.1 - 1.9e-95 320.1 19.7 2.1e-95 319.9 13.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CDF88919.1 - 1.1e-24 86.7 37.5 1.3e-17 63.5 9.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 CDF88919.1 - 0.00024 19.4 4.9 0.00024 19.4 3.4 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Zn_clus PF00172.13 CDF88920.1 - 1.6e-09 37.4 13.6 3.8e-09 36.3 9.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain tRNA_bind PF01588.15 CDF88921.1 - 4.9e-28 96.8 0.0 8.7e-28 96.0 0.0 1.4 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C_2 PF13410.1 CDF88921.1 - 0.00078 19.2 0.0 0.0018 18.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 CDF88921.1 - 0.011 16.2 0.5 0.04 14.3 0.0 2.1 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain DUF737 PF05300.6 CDF88921.1 - 0.034 14.1 5.3 0.057 13.3 3.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF737) SR-25 PF10500.4 CDF88921.1 - 0.073 12.5 9.0 0.13 11.7 6.3 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PAS PF00989.19 CDF88922.1 - 1e-14 54.2 0.0 2e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 PAS fold Zn_clus PF00172.13 CDF88922.1 - 6.9e-05 22.6 8.7 0.00012 21.8 6.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_4 PF08448.5 CDF88922.1 - 0.11 12.4 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 PAS fold EF-hand_7 PF13499.1 CDF88923.1 - 8.3e-11 41.8 0.2 4.9e-08 33.0 0.1 2.2 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.27 CDF88923.1 - 7.5e-08 31.1 4.6 0.00027 20.0 0.1 3.4 3 0 0 3 3 3 2 EF hand EF-hand_9 PF14658.1 CDF88923.1 - 9.3e-08 31.8 0.0 0.0013 18.5 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.1 CDF88923.1 - 1.3e-07 31.1 0.7 7.2e-06 25.5 0.2 3.2 3 1 1 4 4 4 1 EF-hand domain pair EF-hand_6 PF13405.1 CDF88923.1 - 2.2e-07 30.1 2.1 0.00062 19.4 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain UPF0154 PF03672.8 CDF88923.1 - 0.00037 20.0 0.0 0.0082 15.7 0.0 2.2 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0154) FDX-ACB PF03147.9 CDF88923.1 - 0.083 13.0 0.1 0.19 11.9 0.1 1.6 1 1 0 1 1 1 0 Ferredoxin-fold anticodon binding domain EF-hand_4 PF12763.2 CDF88923.1 - 0.094 12.4 0.1 0.24 11.1 0.1 1.7 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.1 CDF88923.1 - 8.5 5.9 10.0 0.61 9.5 0.1 3.0 3 0 0 3 3 3 0 EF hand Vps51 PF08700.6 CDF88924.1 - 4.4e-11 42.4 1.3 4.4e-11 42.4 0.9 1.7 2 0 0 2 2 2 1 Vps51/Vps67 HBS1_N PF08938.5 CDF88924.1 - 0.044 13.8 1.3 0.074 13.1 0.8 1.8 1 1 0 1 1 1 0 HBS1 N-terminus EF-hand_4 PF12763.2 CDF88925.1 - 0.0002 21.0 0.2 0.00051 19.7 0.1 1.7 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand TFIIA PF03153.8 CDF88925.1 - 0.00024 21.1 42.3 0.00024 21.1 29.3 3.0 2 1 1 3 3 3 1 Transcription factor IIA, alpha/beta subunit EF-hand_8 PF13833.1 CDF88925.1 - 0.0018 17.8 0.1 0.0039 16.7 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair DUF3808 PF10300.4 CDF88926.1 - 2.3e-159 530.9 0.5 2.7e-159 530.7 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_2 PF07719.12 CDF88926.1 - 0.0052 16.6 0.3 2.5 8.2 0.0 3.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.1 CDF88926.1 - 0.0053 16.5 1.2 0.079 12.8 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat Clathrin PF00637.15 CDF88926.1 - 0.094 12.3 1.9 0.28 10.7 0.3 2.5 3 0 0 3 3 3 0 Region in Clathrin and VPS TPR_11 PF13414.1 CDF88926.1 - 0.54 9.9 8.0 0.17 11.5 0.1 3.3 4 0 0 4 4 4 0 TPR repeat TPR_16 PF13432.1 CDF88926.1 - 1.5 9.5 7.8 3.9 8.2 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat IBR PF01485.16 CDF88927.1 - 3.6e-17 61.9 41.0 1.1e-09 38.0 8.1 3.8 3 1 0 3 3 3 2 IBR domain zf-C3HC4 PF00097.20 CDF88927.1 - 1.3e-05 24.7 12.4 1.3e-05 24.7 8.6 4.5 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CDF88927.1 - 0.001 18.9 11.3 0.001 18.9 7.8 4.4 4 1 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.1 CDF88927.1 - 0.0083 16.1 12.1 0.0083 16.1 8.4 4.8 3 2 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Actin PF00022.14 CDF88928.1 - 1.6e-94 316.5 0.0 1.1e-93 313.8 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.8 CDF88928.1 - 0.0012 17.4 0.0 0.25 9.9 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein Mitofilin PF09731.4 CDF88929.1 - 4.7e-116 388.7 26.3 9.7e-103 344.8 15.7 2.0 1 1 1 2 2 2 2 Mitochondrial inner membrane protein DUF1104 PF06518.6 CDF88929.1 - 0.28 11.3 10.5 1 9.5 4.7 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1104) DASH_Dad4 PF08650.5 CDF88929.1 - 1.2 9.1 7.3 5.3 7.0 0.1 3.3 4 0 0 4 4 4 0 DASH complex subunit Dad4 DUF2120 PF09893.4 CDF88929.1 - 2.8 7.8 12.6 0.17 11.7 0.2 3.6 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2120) NPV_P10 PF05531.7 CDF88929.1 - 8.3 6.7 11.2 0.93 9.7 0.3 3.9 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Ras PF00071.17 CDF88930.1 - 6.5e-55 184.9 0.8 7.7e-55 184.7 0.5 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDF88930.1 - 2.7e-21 76.2 0.2 4.9e-21 75.4 0.1 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDF88930.1 - 2.8e-15 55.9 0.1 3.9e-15 55.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 CDF88930.1 - 9.5e-09 34.7 0.1 1.2e-08 34.4 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 CDF88930.1 - 1.9e-06 27.4 0.3 3.9e-06 26.4 0.2 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CDF88930.1 - 3.9e-05 23.5 0.0 5.9e-05 23.0 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.17 CDF88930.1 - 0.033 14.3 0.0 0.88 9.7 0.0 2.2 2 0 0 2 2 2 0 RNA helicase Septin PF00735.13 CDF88930.1 - 0.058 12.4 0.1 0.085 11.8 0.0 1.2 1 0 0 1 1 1 0 Septin DUF258 PF03193.11 CDF88930.1 - 0.084 12.0 0.6 0.22 10.7 0.0 2.0 2 1 0 3 3 3 0 Protein of unknown function, DUF258 AAA_16 PF13191.1 CDF88930.1 - 0.094 12.6 0.1 0.11 12.4 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain SRPRB PF09439.5 CDF88930.1 - 0.1 11.7 0.2 0.27 10.4 0.0 1.7 1 1 0 2 2 2 0 Signal recognition particle receptor beta subunit KH_1 PF00013.24 CDF88931.1 - 2.3e-78 257.7 34.1 3e-12 46.0 0.3 12.4 12 1 0 12 12 12 8 KH domain KH_3 PF13014.1 CDF88931.1 - 2.8e-48 160.8 23.4 1.6e-09 37.1 0.0 8.7 8 0 0 8 8 8 6 KH domain KH_2 PF07650.12 CDF88931.1 - 5.6e-12 45.0 13.6 0.00028 20.3 0.0 7.0 5 1 1 6 6 6 3 KH domain KH_4 PF13083.1 CDF88931.1 - 0.001 18.6 13.4 0.015 14.9 0.0 6.5 7 1 1 8 8 8 2 KH domain BMC PF00936.14 CDF88931.1 - 0.045 13.4 5.3 77 3.0 0.0 6.5 8 0 0 8 8 8 0 BMC domain CAP PF00188.21 CDF88932.1 - 5.5e-19 68.8 2.8 5.5e-19 68.8 1.9 2.1 2 1 0 2 2 2 1 Cysteine-rich secretory protein family TFIIA PF03153.8 CDF88932.1 - 3.1 7.6 15.3 3.9 7.2 10.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.4 CDF88932.1 - 7.4 4.7 25.2 10 4.2 17.5 1.2 1 0 0 1 1 1 0 Transmembrane protein Herpes_gE PF02480.11 CDF88933.1 - 0.044 12.0 0.2 0.043 12.0 0.1 1.0 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E NCD3G PF07562.9 CDF88933.1 - 0.088 12.5 1.5 0.13 11.9 1.1 1.3 1 0 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR Cytokin_check_N PF10407.4 CDF88935.1 - 1.2e-32 111.3 1.3 1.2e-30 104.8 0.5 2.5 2 0 0 2 2 2 2 Cdc14 phosphatase binding protein N-terminus SMC_N PF02463.14 CDF88936.1 - 1.3e-49 168.4 72.9 1.6e-48 164.8 50.5 3.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 CDF88936.1 - 2.4e-30 104.9 0.0 1e-29 102.9 0.0 2.2 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.1 CDF88936.1 - 3.2e-11 43.7 27.9 2.2e-06 27.8 8.4 4.6 3 2 0 4 4 4 2 AAA domain AAA_23 PF13476.1 CDF88936.1 - 0.00015 22.1 49.7 0.00015 22.1 34.5 7.2 2 2 3 5 5 5 1 AAA domain AAA_29 PF13555.1 CDF88936.1 - 0.00059 19.3 0.0 0.0018 17.7 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.1 CDF88936.1 - 0.0014 17.1 26.6 0.0014 17.1 18.5 6.3 3 2 2 6 6 6 2 AAA domain FtsK_SpoIIIE PF01580.13 CDF88936.1 - 0.17 11.3 4.7 0.71 9.3 0.0 3.1 2 1 0 2 2 2 0 FtsK/SpoIIIE family Mem_trans PF03547.13 CDF88937.1 - 6e-60 202.5 12.1 9.9e-59 198.5 8.4 1.9 1 1 0 1 1 1 1 Membrane transport protein DnaJ PF00226.26 CDF88938.1 - 7e-21 73.7 4.6 1.5e-20 72.6 3.2 1.6 1 0 0 1 1 1 1 DnaJ domain Apc1 PF12859.2 CDF88938.1 - 0.054 13.7 0.9 0.13 12.4 0.7 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 1 DUF2697 PF10906.3 CDF88938.1 - 2.2 8.3 7.6 1.2 9.2 2.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2697) Peptidase_M28 PF04389.12 CDF88939.1 - 4.2e-36 124.3 0.1 7.9e-36 123.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.17 CDF88939.1 - 4.8e-11 42.2 0.0 1.2e-10 41.0 0.0 1.7 1 0 0 1 1 1 1 PA domain DUF1071 PF06378.6 CDF88940.1 - 0.092 11.8 0.0 0.12 11.5 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1071) Sld5 PF05916.6 CDF88941.1 - 2.9e-18 66.1 1.6 4.6e-18 65.5 1.1 1.3 1 0 0 1 1 1 1 GINS complex protein DUF790 PF05626.6 CDF88941.1 - 0.054 12.0 0.0 0.07 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF790) A_deaminase PF00962.17 CDF88943.1 - 9.5e-22 77.3 0.0 1.5e-10 40.5 0.0 4.0 3 1 0 3 3 3 2 Adenosine/AMP deaminase SecY PF00344.15 CDF88944.1 - 3.5e-55 187.3 15.3 4.9e-55 186.8 10.6 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.4 CDF88944.1 - 3e-08 33.0 0.7 3.7e-07 29.5 0.0 2.8 3 0 0 3 3 3 1 Plug domain of Sec61p MRP-L27 PF09809.4 CDF88945.1 - 7.3e-31 106.1 0.5 1.2e-30 105.4 0.3 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 WD40 PF00400.27 CDF88947.1 - 1.3e-15 56.6 0.2 8.7e-06 25.4 0.0 5.7 6 0 0 6 6 6 3 WD domain, G-beta repeat Peptidase_M20 PF01546.23 CDF88948.1 - 3.3e-26 91.9 0.0 6.7e-26 90.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 CDF88948.1 - 6.4e-13 48.4 0.0 1.2e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain WD40 PF00400.27 CDF88948.1 - 2.9e-10 39.6 6.2 0.047 13.5 0.0 6.4 5 1 0 5 5 5 4 WD domain, G-beta repeat RCC1 PF00415.13 CDF88949.1 - 1.2e-16 60.6 0.7 0.0011 19.1 0.2 5.8 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 CDF88949.1 - 2e-15 55.9 6.0 3.7e-09 35.9 0.2 4.1 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat F-box-like PF12937.2 CDF88949.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 F-box-like Esterase PF00756.15 CDF88950.1 - 2.2e-61 207.4 0.1 2.6e-61 207.2 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Abhydrolase_5 PF12695.2 CDF88950.1 - 0.00037 20.2 0.0 0.00049 19.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 CDF88950.1 - 0.0018 17.1 0.0 0.0026 16.6 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Peptidase_S9 PF00326.16 CDF88950.1 - 0.0052 16.0 0.0 0.0088 15.2 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Lipase_3 PF01764.20 CDF88950.1 - 0.017 14.7 0.0 0.028 14.0 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) PGAP1 PF07819.8 CDF88950.1 - 0.026 14.1 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Paf1 PF03985.8 CDF88951.1 - 5.7e-144 480.0 18.9 5.7e-144 480.0 13.1 1.9 1 1 1 2 2 2 1 Paf1 CBFD_NFYB_HMF PF00808.18 CDF88953.1 - 0.0012 18.8 0.0 0.0028 17.6 0.0 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PSD4 PF07631.6 CDF88953.1 - 0.05 13.9 0.3 0.05 13.9 0.2 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1592) Ndufs5 PF10200.4 CDF88953.1 - 0.09 12.7 0.3 0.18 11.7 0.0 1.7 2 0 0 2 2 2 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa DSPc PF00782.15 CDF88954.1 - 6.5e-26 90.4 0.0 1.4e-21 76.4 0.2 3.6 3 0 0 3 3 3 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 CDF88954.1 - 1.1e-05 24.9 0.1 2.2e-05 23.9 0.1 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.7 CDF88954.1 - 0.00013 21.4 0.1 0.00033 20.1 0.0 1.6 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.1 CDF88954.1 - 0.017 15.2 0.1 0.065 13.2 0.0 1.9 2 0 0 2 2 2 0 Inositol hexakisphosphate PALP PF00291.20 CDF88955.1 - 1.2e-59 202.1 0.0 1.3e-59 201.9 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Ribosomal_L17 PF01196.14 CDF88956.1 - 2.6e-25 88.7 0.0 5.9e-25 87.6 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L17 Coiled-coil_56 PF09813.4 CDF88957.1 - 0.029 14.3 0.1 0.089 12.7 0.0 1.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 56 adh_short PF00106.20 CDF88958.1 - 5.1e-24 85.0 0.0 9.8e-24 84.1 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CDF88958.1 - 3.2e-14 53.0 0.0 4.3e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 CDF88958.1 - 0.0012 18.6 0.0 0.0016 18.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase SBF PF01758.11 CDF88958.1 - 0.041 13.2 0.2 0.073 12.4 0.1 1.4 1 0 0 1 1 1 0 Sodium Bile acid symporter family NAD_binding_10 PF13460.1 CDF88958.1 - 0.048 13.6 0.1 0.3 11.0 0.1 2.0 1 1 0 1 1 1 0 NADH(P)-binding Polysacc_synt_2 PF02719.10 CDF88958.1 - 0.12 11.2 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein zf-C2H2_2 PF12756.2 CDF88959.1 - 3.5e-38 129.7 5.3 1.2e-34 118.4 0.8 2.8 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 CDF88959.1 - 0.0016 18.4 1.4 0.0016 18.4 1.0 4.3 4 1 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 CDF88959.1 - 0.042 14.1 10.0 2.3 8.7 0.7 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-met PF12874.2 CDF88959.1 - 0.13 12.4 11.5 0.3 11.3 0.1 3.6 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.21 CDF88959.1 - 0.15 12.5 12.5 0.35 11.3 0.9 3.2 3 0 0 3 3 3 0 Zinc finger, C2H2 type AKAP95 PF04988.7 CDF88959.1 - 0.15 11.8 15.6 1.8 8.3 2.5 4.0 3 1 0 3 3 3 0 A-kinase anchoring protein 95 (AKAP95) Phosphodiest PF01663.17 CDF88960.1 - 1e-12 48.0 1.7 1.1e-09 38.0 0.0 2.2 1 1 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.13 CDF88960.1 - 6.5e-05 22.4 0.1 0.00013 21.4 0.0 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.18 CDF88960.1 - 0.027 13.6 0.0 0.059 12.5 0.0 1.6 1 0 0 1 1 1 0 Sulfatase Ribosomal_L37 PF08561.5 CDF88961.1 - 1.1e-27 95.3 1.4 1.3e-27 95.1 1.0 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 DUF4548 PF15081.1 CDF88961.1 - 0.056 12.9 0.0 0.063 12.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4548) Nup88 PF10168.4 CDF88962.1 - 0.0066 14.3 0.0 0.0066 14.3 0.0 3.1 2 2 0 4 4 4 1 Nuclear pore component DUF1654 PF07867.6 CDF88962.1 - 0.018 14.4 0.4 4.4 6.7 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1654) DUF2265 PF10023.4 CDF88962.1 - 0.12 11.4 3.6 0.29 10.2 2.5 1.6 1 0 0 1 1 1 0 Predicted aminopeptidase (DUF2265) DUF1674 PF07896.7 CDF88963.1 - 2.6e-16 59.5 0.9 5.2e-16 58.5 0.7 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) Aminotran_1_2 PF00155.16 CDF88964.1 - 5.1e-82 275.7 0.0 6.1e-82 275.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 CDF88964.1 - 3.9e-05 22.8 0.0 7e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.15 CDF88964.1 - 0.00055 18.3 0.0 0.001 17.4 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.16 CDF88964.1 - 0.098 11.7 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Aminotran_5 PF00266.14 CDF88964.1 - 0.12 11.0 0.1 0.64 8.6 0.0 1.9 2 0 0 2 2 2 0 Aminotransferase class-V CLN3 PF02487.12 CDF88965.1 - 2.2e-140 467.9 18.3 4.3e-139 463.7 12.7 2.0 1 1 0 1 1 1 1 CLN3 protein PrgI PF12666.2 CDF88965.1 - 1 9.5 6.8 0.88 9.7 0.1 3.0 2 0 0 2 2 2 0 PrgI family protein HbrB PF08539.6 CDF88966.1 - 1.8e-35 122.1 3.5 2.5e-35 121.6 2.5 1.2 1 0 0 1 1 1 1 HbrB-like Pkinase PF00069.20 CDF88967.1 - 9.1e-38 129.8 0.0 2.7e-37 128.3 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF88967.1 - 7.9e-21 74.2 0.0 4.4e-20 71.8 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.9 CDF88967.1 - 0.0089 15.1 0.0 0.015 14.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 CDF88967.1 - 0.018 14.0 0.0 0.037 13.0 0.0 1.5 1 0 0 1 1 1 0 Kinase-like Erythrovirus_X PF06795.6 CDF88967.1 - 0.094 12.7 0.1 0.35 10.9 0.1 1.9 1 0 0 1 1 1 0 Erythrovirus X protein Gemini_mov PF01708.11 CDF88967.1 - 0.12 11.9 0.0 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 Geminivirus putative movement protein DUF2201_N PF13203.1 CDF88967.1 - 0.18 10.9 0.0 0.39 9.8 0.0 1.5 1 1 0 1 1 1 0 Putative metallopeptidase domain Methyltransf_16 PF10294.4 CDF88968.1 - 2.3e-21 75.9 0.0 4.3e-21 75.1 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.1 CDF88968.1 - 9.3e-06 25.4 0.0 1.8e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDF88968.1 - 1.6e-05 24.5 0.0 4.9e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDF88968.1 - 0.00099 19.6 0.0 0.0025 18.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain HTH_26 PF13443.1 CDF88968.1 - 0.0018 18.3 0.1 0.018 15.2 0.1 2.4 2 0 0 2 2 2 1 Cro/C1-type HTH DNA-binding domain Methyltransf_12 PF08242.7 CDF88968.1 - 0.022 15.2 0.0 0.071 13.5 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.9 CDF88968.1 - 0.055 12.8 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_26 PF13659.1 CDF88968.1 - 0.063 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.15 CDF88968.1 - 0.075 12.0 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase zf-H2C2_2 PF13465.1 CDF88969.1 - 1.7e-24 84.8 52.9 6.2e-09 35.7 0.3 7.5 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.21 CDF88969.1 - 6.2e-11 41.9 19.7 9.6e-06 25.6 1.0 10.2 10 0 0 10 10 10 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CDF88969.1 - 1.2e-07 31.5 76.0 0.0043 17.2 0.6 9.8 9 0 0 9 9 9 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CDF88969.1 - 3.3e-07 30.2 33.0 0.024 14.7 1.4 7.0 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.1 CDF88969.1 - 0.0069 16.5 0.6 0.0069 16.5 0.4 9.4 9 0 0 9 9 9 5 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.1 CDF88969.1 - 0.008 16.0 29.7 0.011 15.5 1.2 6.3 5 1 1 6 6 6 3 C2H2-type zinc finger zf-met PF12874.2 CDF88969.1 - 0.0089 16.2 1.1 0.0089 16.2 0.8 6.1 6 0 0 6 6 6 3 Zinc-finger of C2H2 type Aldo_ket_red PF00248.16 CDF88970.1 - 1.2e-23 83.3 0.0 1.6e-23 82.9 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Lysine_decarbox PF03641.9 CDF88971.1 - 2.2e-42 144.0 0.0 2.8e-42 143.7 0.0 1.1 1 0 0 1 1 1 1 Possible lysine decarboxylase zf-C2H2 PF00096.21 CDF88971.1 - 0.18 12.2 0.3 0.69 10.3 0.0 2.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type Tim54 PF11711.3 CDF88972.1 - 8.8e-131 435.9 2.8 1.1e-130 435.7 1.9 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Peptidase_M27 PF01742.12 CDF88972.1 - 0.043 12.6 0.1 0.065 12.0 0.1 1.2 1 0 0 1 1 1 0 Clostridial neurotoxin zinc protease Nop25 PF09805.4 CDF88972.1 - 0.88 9.6 18.4 0.28 11.2 2.7 2.4 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) DUF1770 PF08589.5 CDF88972.1 - 3.1 8.4 9.7 0.25 11.9 2.7 2.0 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1770) Syntaxin PF00804.20 CDF88973.1 - 2.3e-18 66.2 1.5 2.3e-18 66.2 1.1 3.1 3 1 0 3 3 3 1 Syntaxin SNARE PF05739.14 CDF88973.1 - 4.3e-16 58.3 2.7 4.3e-16 58.3 1.8 2.5 3 0 0 3 3 3 1 SNARE domain Sed5p PF11416.3 CDF88973.1 - 7e-09 34.9 0.4 7e-09 34.9 0.3 2.5 2 0 0 2 2 2 1 Integral membrane protein Sed5p Syntaxin-18_N PF10496.4 CDF88973.1 - 0.00021 21.0 3.1 0.00021 21.0 2.2 1.9 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus FlaC_arch PF05377.6 CDF88973.1 - 0.053 13.4 1.6 1.2 9.1 0.0 3.3 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF972 PF06156.8 CDF88973.1 - 8.2 6.8 15.7 0.062 13.6 0.9 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF972) Filament PF00038.16 CDF88976.1 - 0.00056 19.4 0.3 0.00056 19.4 0.2 1.6 2 0 0 2 2 2 1 Intermediate filament protein Rootletin PF15035.1 CDF88976.1 - 0.0051 16.7 2.0 0.0051 16.7 1.4 1.8 2 0 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion Herpes_UL25 PF01499.11 CDF88976.1 - 0.02 13.2 3.5 0.028 12.7 2.4 1.2 1 0 0 1 1 1 0 Herpesvirus UL25 family FlaC_arch PF05377.6 CDF88976.1 - 0.21 11.4 4.1 0.42 10.5 2.8 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DivIC PF04977.10 CDF88976.1 - 8.7 5.9 9.3 1.2 8.6 3.2 2.0 2 1 0 2 2 2 0 Septum formation initiator SH3_1 PF00018.23 CDF88977.1 - 1.3e-14 53.3 0.1 1.8e-14 52.8 0.1 1.2 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 CDF88977.1 - 1.1e-12 47.2 0.0 1.7e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 CDF88977.1 - 1.1e-10 40.8 0.0 1.5e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain hSH3 PF14603.1 CDF88977.1 - 0.073 13.0 0.0 0.2 11.7 0.0 1.6 2 0 0 2 2 2 0 Helically-extended SH3 domain Sdh_cyt PF01127.17 CDF88978.1 - 7.3e-26 90.3 3.0 9.3e-26 90.0 2.1 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit PepSY_TM_3 PF13706.1 CDF88978.1 - 4.3 6.8 7.4 0.51 9.7 0.5 2.4 2 0 0 2 2 2 0 PepSY-associated TM helix Abhydrolase_1 PF00561.15 CDF88979.1 - 9.4e-24 84.2 0.1 1.3e-23 83.7 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.11 CDF88979.1 - 3.3e-19 68.0 0.1 6.2e-19 67.1 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_6 PF12697.2 CDF88979.1 - 2.4e-06 27.5 0.0 3.6e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CDF88979.1 - 1.6e-05 24.6 0.0 8.5e-05 22.3 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.8 CDF88979.1 - 0.00014 21.3 0.0 0.094 12.1 0.0 2.2 2 0 0 2 2 2 2 Serine hydrolase (FSH1) Ndr PF03096.9 CDF88979.1 - 0.0035 15.8 0.0 0.0066 14.9 0.0 1.3 1 0 0 1 1 1 1 Ndr family Abhydrolase_2 PF02230.11 CDF88979.1 - 0.0047 16.4 0.1 2.4 7.5 0.0 2.4 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Pkinase PF00069.20 CDF88980.1 - 1.3e-73 247.3 0.0 1.8e-73 246.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF88980.1 - 4e-35 121.1 0.0 6.1e-35 120.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF88980.1 - 3.6e-07 29.4 0.0 6.2e-07 28.6 0.0 1.6 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 CDF88980.1 - 0.0087 15.8 0.0 0.018 14.7 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.9 CDF88980.1 - 0.0091 15.0 0.2 0.066 12.2 0.1 2.0 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1871 PF08958.5 CDF88980.1 - 0.024 14.7 0.4 0.07 13.2 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1871) Seadorna_VP7 PF07387.6 CDF88980.1 - 0.053 12.3 0.1 0.082 11.7 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 DASH_Hsk3 PF08227.6 CDF88981.1 - 3.8e-18 65.3 4.6 4.9e-18 65.0 3.2 1.1 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like GvpK PF05121.7 CDF88981.1 - 0.034 13.9 0.1 0.044 13.6 0.1 1.1 1 0 0 1 1 1 0 Gas vesicle protein K YebO PF13974.1 CDF88981.1 - 0.044 13.5 0.2 0.047 13.4 0.2 1.1 1 0 0 1 1 1 0 YebO-like protein CENP-Q PF13094.1 CDF88981.1 - 0.31 11.0 2.5 0.42 10.6 1.7 1.1 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Spc24 PF08286.6 CDF88982.1 - 4.9e-20 71.3 1.6 4.9e-20 71.3 1.1 2.2 1 1 1 2 2 2 1 Spc24 subunit of Ndc80 NOSIC PF08060.8 CDF88982.1 - 0.7 9.7 4.2 12 5.7 0.0 2.8 2 1 0 2 2 2 0 NOSIC (NUC001) domain TMF_DNA_bd PF12329.3 CDF88982.1 - 1.1 9.1 11.1 0.72 9.6 6.0 2.0 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding L31 PF09784.4 CDF88983.1 - 2.3e-41 140.0 0.6 3e-41 139.6 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 Cmc1 PF08583.5 CDF88984.1 - 1.1e-19 69.9 4.0 1.5e-19 69.5 2.8 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like COX17 PF05051.8 CDF88984.1 - 0.15 12.0 3.0 2.9 7.9 0.2 2.3 2 0 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) SAE2 PF08573.5 CDF88984.1 - 0.24 12.1 1.8 0.36 11.5 1.3 1.3 1 0 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Adaptin_N PF01602.15 CDF88985.1 - 1.2e-126 423.1 19.1 1.8e-126 422.5 13.3 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.2 CDF88985.1 - 4.8e-21 75.3 3.5 4.8e-21 75.3 2.4 2.7 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.1 CDF88985.1 - 2e-10 40.7 1.7 2.5e-06 27.6 0.1 5.1 3 2 3 6 6 6 2 HEAT repeats HEAT PF02985.17 CDF88985.1 - 2.9e-09 36.2 1.1 0.014 15.4 0.0 5.8 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.1 CDF88985.1 - 0.0087 16.5 1.1 7.6 7.1 0.0 4.3 4 0 0 4 4 4 1 HEAT-like repeat Arm PF00514.18 CDF88985.1 - 0.01 15.6 1.8 1.3 8.9 0.1 3.8 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Condensin2nSMC PF12422.3 CDF88985.1 - 0.18 11.5 2.8 2.8 7.6 0.1 3.9 4 0 0 4 4 4 0 Condensin II non structural maintenance of chromosomes subunit WD40 PF00400.27 CDF88986.1 - 2.9e-53 175.9 8.7 2.2e-08 33.6 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.3 CDF88986.1 - 1.6e-05 23.2 5.9 0.051 11.7 0.1 4.1 2 1 2 4 4 4 2 Nucleoporin Nup120/160 eIF2A PF08662.6 CDF88986.1 - 2.5e-05 24.0 0.5 0.00096 18.9 0.0 2.9 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.6 CDF88986.1 - 0.011 14.4 0.3 7.3 5.2 0.3 3.4 2 1 0 3 3 3 0 Nup133 N terminal like Gmad2 PF10648.4 CDF88986.1 - 0.098 12.8 0.2 2.6 8.2 0.0 2.5 2 1 0 2 2 2 0 Immunoglobulin-like domain of bacterial spore germination Peptidase_M3 PF01432.15 CDF88987.1 - 8.2e-138 460.2 0.0 1.2e-137 459.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M50B PF13398.1 CDF88987.1 - 0.17 11.2 0.3 0.28 10.5 0.2 1.2 1 0 0 1 1 1 0 Peptidase M50B-like TPR_12 PF13424.1 CDF88988.1 - 2e-05 24.4 4.6 0.95 9.4 0.0 4.5 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.1 CDF88988.1 - 0.0038 16.9 1.1 2.8 7.9 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.1 CDF88988.1 - 0.025 14.2 2.5 1 9.0 0.2 3.5 3 0 0 3 3 3 0 TPR repeat DUF159 PF02586.9 CDF88989.1 - 2.9e-55 187.0 2.2 2.9e-55 187.0 1.5 1.8 2 0 0 2 2 2 1 Uncharacterised ACR, COG2135 LMBR1 PF04791.11 CDF88989.1 - 0.37 9.3 12.5 0.43 9.0 8.3 1.3 1 1 0 1 1 1 0 LMBR1-like membrane protein Mur_ligase_M PF08245.7 CDF88990.1 - 2.5e-05 24.3 0.0 6e-05 23.1 0.0 1.7 1 1 0 1 1 1 1 Mur ligase middle domain DUF2404 PF10296.4 CDF88990.1 - 0.044 13.9 0.0 0.55 10.3 0.0 2.2 2 0 0 2 2 2 0 Putative integral membrane protein conserved region (DUF2404) Med11 PF10280.4 CDF88991.1 - 1.5e-25 89.4 1.8 1.7e-25 89.3 1.2 1.0 1 0 0 1 1 1 1 Mediator complex protein Med29 PF11568.3 CDF88991.1 - 0.047 13.7 0.3 0.051 13.6 0.2 1.2 1 0 0 1 1 1 0 Mediator complex subunit 29 DUF1436 PF07262.6 CDF88991.1 - 0.056 12.9 0.1 0.076 12.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1436) DUF4546 PF15079.1 CDF88991.1 - 0.074 12.1 0.7 0.11 11.6 0.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4546) Pedibin PF08182.6 CDF88991.1 - 0.18 11.3 1.2 6 6.4 0.0 2.6 2 0 0 2 2 2 0 Pedibin/Hym-346 family GCR1_C PF12550.3 CDF88992.1 - 1.6e-25 88.7 0.5 3.8e-25 87.5 0.3 1.7 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes DUF977 PF06163.6 CDF88992.1 - 0.053 13.2 0.6 0.13 11.9 0.4 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF977) She2p PF11435.3 CDF88993.1 - 1.3e-85 285.9 10.9 1.7e-85 285.5 7.6 1.1 1 0 0 1 1 1 1 RNA binding protein She2p Jacalin PF01419.12 CDF88993.1 - 0.03 14.2 0.2 0.076 12.9 0.1 1.7 1 0 0 1 1 1 0 Jacalin-like lectin domain TypeIII_RM_meth PF12564.3 CDF88993.1 - 0.12 12.4 2.3 1.4 8.9 0.5 3.3 2 1 1 3 3 3 0 Type III restriction/modification enzyme methylation subunit Myosin_head PF00063.16 CDF88994.1 - 1.1e-226 754.1 7.0 1.9e-226 753.3 4.8 1.4 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.8 CDF88994.1 - 1.1e-48 165.1 1.8 1.2e-48 165.0 0.4 1.7 2 0 0 2 2 2 1 Myosin tail SH3_1 PF00018.23 CDF88994.1 - 4e-11 42.1 0.0 7.9e-11 41.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 CDF88994.1 - 3.3e-08 32.9 0.1 6.6e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 CDF88994.1 - 1.1e-05 24.7 0.0 2.7e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.6 CDF88994.1 - 0.0018 18.4 1.3 0.0039 17.3 0.1 2.2 2 0 0 2 2 2 1 Bacterial SH3 domain AAA_22 PF13401.1 CDF88994.1 - 0.0046 17.0 0.0 0.014 15.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CDF88994.1 - 0.022 14.5 0.0 0.11 12.3 0.0 2.1 2 0 0 2 2 2 0 Part of AAA domain AAA_17 PF13207.1 CDF88994.1 - 0.039 14.7 0.1 0.22 12.3 0.0 2.4 2 0 0 2 2 1 0 AAA domain AAA_16 PF13191.1 CDF88994.1 - 0.04 13.9 0.1 0.33 10.9 0.0 2.5 3 0 0 3 3 3 0 AAA ATPase domain Sigma54_activat PF00158.21 CDF88994.1 - 0.042 13.3 0.0 0.09 12.2 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Hpr_kinase_C PF07475.7 CDF88994.1 - 0.046 13.0 0.1 4.8 6.4 0.0 2.6 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain NACHT PF05729.7 CDF88994.1 - 0.067 12.8 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain TPP_enzyme_N PF02776.13 CDF88995.1 - 6.1e-59 198.3 0.2 4.3e-58 195.5 0.1 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 CDF88995.1 - 5.3e-50 168.9 0.0 2.5e-48 163.5 0.0 2.6 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 CDF88995.1 - 2.1e-35 121.4 0.4 2.3e-34 118.0 0.1 2.7 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, central domain Glyco_tran_WecB PF03808.8 CDF88995.1 - 0.1 12.0 0.0 3.2 7.1 0.0 2.6 3 0 0 3 3 3 0 Glycosyl transferase WecB/TagA/CpsF family His_Phos_1 PF00300.17 CDF88996.1 - 1.6e-17 64.0 0.1 2e-17 63.7 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) YdjC PF04794.7 CDF88996.1 - 0.08 12.3 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 YdjC-like protein Mago_nashi PF02792.9 CDF88996.1 - 0.095 12.3 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Mago nashi protein Auxin_inducible PF02519.9 CDF88997.1 - 0.02 14.9 0.0 0.024 14.6 0.0 1.2 1 0 0 1 1 1 0 Auxin responsive protein Ku PF02735.11 CDF88999.1 - 2e-28 99.1 0.0 3.5e-28 98.3 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.10 CDF88999.1 - 1.4e-18 67.1 0.0 2.2e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain PGM_PMM_I PF02878.11 CDF89000.1 - 6.4e-34 116.3 0.1 1.1e-33 115.6 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.11 CDF89000.1 - 6.7e-25 87.3 0.0 1.1e-24 86.5 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.11 CDF89000.1 - 3.5e-14 52.9 0.0 8.4e-14 51.7 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 CDF89000.1 - 1.3e-08 34.7 0.0 2.8e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Pkinase PF00069.20 CDF89001.1 - 6e-69 232.0 0.0 8.1e-69 231.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF89001.1 - 1.5e-31 109.4 0.0 2.2e-31 108.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 CDF89001.1 - 2.4e-10 40.7 0.2 7e-10 39.2 0.2 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 CDF89001.1 - 0.0014 17.6 0.0 0.0032 16.4 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Ribosomal_L44 PF00935.14 CDF89001.1 - 0.036 14.0 0.3 0.036 14.0 0.2 1.7 2 0 0 2 2 2 0 Ribosomal protein L44 Kdo PF06293.9 CDF89001.1 - 0.04 12.9 0.0 0.077 12.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RRN3 PF05327.6 CDF89002.1 - 1.5e-178 594.4 11.6 1.8e-178 594.2 8.0 1.0 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Matrilin_ccoil PF10393.4 CDF89002.1 - 0.024 13.9 0.6 0.1 11.9 0.1 2.2 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin PACT_coil_coil PF10495.4 CDF89002.1 - 0.056 13.3 0.1 0.16 11.9 0.0 1.8 1 0 0 1 1 1 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein SPRY PF00622.23 CDF89003.1 - 3.1e-13 49.8 0.0 6.8e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 SPRY domain SRP9-21 PF05486.7 CDF89004.1 - 1.7e-23 82.1 0.1 3.1e-23 81.3 0.1 1.4 1 0 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) WD40 PF00400.27 CDF89005.1 - 1.3e-23 81.9 14.4 1.3e-07 31.1 0.1 7.3 7 0 0 7 7 7 4 WD domain, G-beta repeat BBS2_Mid PF14783.1 CDF89005.1 - 0.00033 20.4 0.0 3 7.6 0.0 3.9 3 1 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region Mito_carr PF00153.22 CDF89006.1 - 3.4e-64 212.5 5.9 5.6e-23 80.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Prenyltransf PF01255.14 CDF89007.1 - 2.4e-67 226.3 0.1 3e-67 226.0 0.1 1.1 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Vma12 PF11712.3 CDF89008.1 - 9.6e-33 112.8 0.3 1.2e-32 112.5 0.2 1.3 1 1 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF3792 PF12670.2 CDF89008.1 - 0.043 13.6 0.6 0.064 13.1 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3792) zf-MYND PF01753.13 CDF89009.1 - 3.7e-08 33.1 17.6 8.7e-08 31.9 12.2 1.7 1 1 0 1 1 1 1 MYND finger CS PF04969.11 CDF89010.1 - 0.0055 17.2 0.0 0.01 16.3 0.0 1.6 1 0 0 1 1 1 1 CS domain Pkinase PF00069.20 CDF89011.1 - 5.6e-55 186.2 0.0 7.9e-55 185.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF89011.1 - 6.5e-23 81.1 0.0 9.3e-22 77.3 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF89011.1 - 0.00058 18.9 0.0 0.001 18.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like AP_endonuc_2 PF01261.19 CDF89012.1 - 8.2e-30 103.6 0.0 1.1e-29 103.2 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel HpaB_N PF11794.3 CDF89012.1 - 0.019 14.3 0.0 0.032 13.6 0.0 1.4 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal UTP15_C PF09384.5 CDF89012.1 - 0.2 11.3 0.0 0.2 11.3 0.0 2.2 2 1 1 3 3 3 0 UTP15 C terminal XPG_N PF00752.12 CDF89013.1 - 5e-38 129.4 0.0 9.5e-38 128.5 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.13 CDF89013.1 - 4e-28 97.3 0.0 8.6e-28 96.2 0.0 1.6 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.15 CDF89013.1 - 2.5e-06 27.6 0.0 2.5e-06 27.6 0.0 2.4 3 0 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.1 CDF89013.1 - 0.0083 16.2 0.1 0.031 14.4 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH_2 PF12826.2 CDF89013.1 - 0.018 14.9 0.0 0.054 13.3 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif HXXSHH PF07586.6 CDF89013.1 - 0.048 12.5 0.2 0.087 11.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) Transposase_20 PF02371.11 CDF89013.1 - 0.067 13.3 0.1 0.23 11.6 0.0 1.9 2 0 0 2 2 2 0 Transposase IS116/IS110/IS902 family Asp PF00026.18 CDF89014.1 - 6.9e-76 255.5 9.0 1e-75 254.9 6.2 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 CDF89014.1 - 2.7e-07 30.6 1.9 2.7e-07 30.6 1.3 2.1 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 CDF89014.1 - 0.0014 18.1 0.4 0.074 12.6 0.0 2.5 1 1 1 2 2 2 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.1 CDF89014.1 - 0.0017 18.8 4.1 19 5.8 1.8 3.9 2 1 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.1 CDF89014.1 - 0.0036 17.0 0.0 1 9.2 0.0 2.6 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Inhibitor_I36 PF03995.8 CDF89014.1 - 0.021 15.1 2.4 0.021 15.1 1.6 2.8 3 1 0 3 3 3 0 Peptidase inhibitor family I36 RVP PF00077.15 CDF89014.1 - 0.034 14.0 0.5 1.6 8.7 0.0 2.8 2 0 0 2 2 2 0 Retroviral aspartyl protease BAF1_ABF1 PF04684.8 CDF89015.1 - 2.8e-124 415.6 14.7 1.4e-112 377.0 2.8 3.3 1 1 0 2 2 2 2 BAF1 / ABF1 chromatin reorganising factor DBD_Tnp_Mut PF03108.10 CDF89015.1 - 0.0011 18.4 0.4 0.0023 17.4 0.3 1.4 1 0 0 1 1 1 1 MuDR family transposase DUF429 PF04250.8 CDF89015.1 - 0.0049 16.1 0.5 0.011 14.9 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF429) OAD_gamma PF04277.8 CDF89015.1 - 0.016 15.5 1.2 0.088 13.1 0.1 2.3 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain mRNA_stabil PF13929.1 CDF89016.1 - 1.7e-98 329.1 0.1 2.7e-98 328.5 0.1 1.3 1 0 0 1 1 1 1 mRNA stabilisation Oligomerisation PF02410.10 CDF89016.1 - 4.5e-17 61.9 0.1 1.8e-16 60.0 0.0 2.0 2 0 0 2 2 2 1 Oligomerisation domain XPC-binding PF09280.6 CDF89016.1 - 0.039 13.4 0.5 0.1 12.0 0.3 1.8 1 0 0 1 1 1 0 XPC-binding domain KTI12 PF08433.5 CDF89017.1 - 1.1e-95 319.9 0.0 1.2e-95 319.7 0.0 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.1 CDF89017.1 - 2.9e-08 33.7 0.0 5.3e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CDF89017.1 - 4.7e-06 26.9 0.0 1.3e-05 25.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CDF89017.1 - 9.1e-06 26.5 0.0 1.7e-05 25.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.15 CDF89017.1 - 0.00011 21.8 0.0 0.00021 20.9 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_16 PF13191.1 CDF89017.1 - 0.00086 19.3 0.1 0.0084 16.1 0.0 2.4 1 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 CDF89017.1 - 0.0023 18.0 0.0 0.01 15.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 CDF89017.1 - 0.018 14.2 0.0 0.031 13.4 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI 6PF2K PF01591.13 CDF89017.1 - 0.03 13.4 0.1 1.7 7.6 0.0 2.6 3 0 0 3 3 3 0 6-phosphofructo-2-kinase CPT PF07931.7 CDF89017.1 - 0.035 13.7 0.0 0.088 12.4 0.0 1.6 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Elong_Iki1 PF10483.4 CDF89017.1 - 0.044 13.1 0.0 0.3 10.4 0.0 1.9 2 0 0 2 2 2 0 Elongator subunit Iki1 AAA PF00004.24 CDF89017.1 - 0.06 13.5 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 CDF89017.1 - 0.062 13.2 0.0 0.14 12.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain MobB PF03205.9 CDF89017.1 - 0.1 12.3 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.1 CDF89017.1 - 0.11 12.0 0.2 0.45 10.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain Telomere_Sde2 PF13019.1 CDF89017.1 - 0.12 12.0 0.1 0.27 10.8 0.0 1.6 1 0 0 1 1 1 0 Telomere stability and silencing Hap4_Hap_bind PF10297.4 CDF89019.1 - 5.5e-09 35.5 8.6 5.5e-09 35.5 5.9 2.3 2 0 0 2 2 2 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 Tmemb_cc2 PF10267.4 CDF89019.1 - 0.009 14.6 0.7 0.009 14.6 0.5 1.9 2 0 0 2 2 2 1 Predicted transmembrane and coiled-coil 2 protein SOR_SNZ PF01680.12 CDF89020.1 - 8.4e-106 352.2 5.1 1.2e-105 351.6 3.5 1.2 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.9 CDF89020.1 - 7e-09 35.1 2.5 9e-08 31.4 0.1 2.4 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG NMO PF03060.10 CDF89020.1 - 0.0046 16.1 0.2 0.0046 16.1 0.2 2.1 2 1 0 2 2 2 1 Nitronate monooxygenase His_biosynth PF00977.16 CDF89020.1 - 0.0084 15.4 0.1 0.048 12.9 0.0 2.0 2 0 0 2 2 2 1 Histidine biosynthesis protein Dus PF01207.12 CDF89020.1 - 0.011 14.5 0.5 2.8 6.7 0.0 2.8 2 1 1 3 3 3 0 Dihydrouridine synthase (Dus) IGPS PF00218.16 CDF89020.1 - 0.015 14.4 0.1 0.15 11.0 0.0 2.5 2 1 1 3 3 3 0 Indole-3-glycerol phosphate synthase NanE PF04131.9 CDF89020.1 - 0.024 13.6 1.6 0.3 10.0 0.0 2.9 2 2 1 3 3 3 0 Putative N-acetylmannosamine-6-phosphate epimerase UBN2 PF14223.1 CDF89020.1 - 0.026 14.2 0.8 25 4.6 0.0 3.8 4 0 0 4 4 4 0 gag-polypeptide of LTR copia-type 1-cysPrx_C PF10417.4 CDF89020.1 - 0.053 13.1 0.2 3.4 7.3 0.0 2.7 2 0 0 2 2 2 0 C-terminal domain of 1-Cys peroxiredoxin TMP-TENI PF02581.12 CDF89020.1 - 0.059 12.4 0.4 1.3 8.1 0.1 2.4 2 0 0 2 2 2 0 Thiamine monophosphate synthase/TENI T4SS PF07996.6 CDF89020.1 - 0.15 11.9 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion system proteins SNO PF01174.14 CDF89021.1 - 2.8e-83 278.1 0.0 3.2e-83 277.9 0.0 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.9 CDF89021.1 - 6.5e-08 32.3 0.0 2.4e-07 30.5 0.0 1.9 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.23 CDF89021.1 - 1.3e-06 27.9 0.0 1.6e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I DUF4066 PF13278.1 CDF89021.1 - 0.032 13.5 0.0 0.049 12.8 0.0 1.3 1 0 0 1 1 1 0 Putative amidotransferase DJ-1_PfpI PF01965.19 CDF89021.1 - 0.036 13.5 0.0 0.053 12.9 0.0 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family Drc1-Sld2 PF11719.3 CDF89023.1 - 4.1e-58 197.4 32.4 2.2e-57 195.0 22.5 1.8 1 1 0 1 1 1 1 DNA replication and checkpoint protein UTP15_C PF09384.5 CDF89024.1 - 6.1e-49 165.5 0.1 9e-49 164.9 0.1 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.27 CDF89024.1 - 2.2e-21 74.8 3.2 1.8e-05 24.4 0.0 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat BBS2_Mid PF14783.1 CDF89024.1 - 0.0089 15.7 0.1 0.93 9.2 0.0 3.4 3 2 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region DUF328 PF03883.9 CDF89024.1 - 0.018 14.3 0.0 0.064 12.5 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF328) WD40 PF00400.27 CDF89025.1 - 3.3e-29 99.6 23.6 0.00024 20.8 0.0 10.4 11 1 0 11 11 11 7 WD domain, G-beta repeat eIF2A PF08662.6 CDF89025.1 - 2.5e-06 27.3 0.1 0.006 16.3 0.0 3.7 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.1 CDF89025.1 - 0.00017 21.1 0.6 0.21 10.9 0.0 2.6 2 0 0 2 2 2 2 PQQ-like domain Nup160 PF11715.3 CDF89025.1 - 0.0096 14.1 0.0 0.021 12.9 0.0 1.6 1 0 0 1 1 1 1 Nucleoporin Nup120/160 CRC_subunit PF08624.5 CDF89026.1 - 8.8e-55 184.4 0.1 1.6e-54 183.6 0.0 1.4 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Peptidase_M41 PF01434.13 CDF89027.1 - 4.9e-72 241.8 2.1 1.3e-71 240.4 0.0 2.1 2 0 0 2 2 2 1 Peptidase family M41 AAA PF00004.24 CDF89027.1 - 2.3e-40 137.8 0.0 6.1e-40 136.4 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) FtsH_ext PF06480.10 CDF89027.1 - 4.3e-08 33.3 0.0 9.9e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 FtsH Extracellular AAA_17 PF13207.1 CDF89027.1 - 0.00085 20.1 2.4 0.0046 17.7 0.0 3.0 3 0 0 3 3 2 1 AAA domain TIP49 PF06068.8 CDF89027.1 - 0.0068 15.1 0.0 0.015 14.0 0.0 1.5 1 0 0 1 1 1 1 TIP49 C-terminus AAA_22 PF13401.1 CDF89027.1 - 0.011 15.9 0.1 0.85 9.7 0.1 2.7 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.7 CDF89027.1 - 0.025 13.6 0.0 0.049 12.6 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus UPF0233 PF06781.7 CDF89027.1 - 0.027 14.0 0.0 11 5.6 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0233) AAA_19 PF13245.1 CDF89027.1 - 0.028 14.1 0.3 0.076 12.7 0.2 1.7 1 0 0 1 1 1 0 Part of AAA domain Fe-ADH_2 PF13685.1 CDF89027.1 - 0.034 13.4 0.0 0.6 9.3 0.0 2.6 3 0 0 3 3 3 0 Iron-containing alcohol dehydrogenase AAA_5 PF07728.9 CDF89027.1 - 0.035 13.8 0.1 0.18 11.5 0.0 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF883 PF05957.8 CDF89027.1 - 0.06 13.7 3.7 0.18 12.2 2.6 1.8 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) AAA_25 PF13481.1 CDF89027.1 - 0.096 12.0 1.3 0.58 9.5 0.4 2.5 1 1 1 2 2 2 0 AAA domain AAA_18 PF13238.1 CDF89027.1 - 0.45 10.8 0.0 0.45 10.8 0.0 3.2 2 1 0 2 2 1 0 AAA domain DUF4407 PF14362.1 CDF89027.1 - 4.4 6.1 6.3 7.8 5.3 4.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MFS_1 PF07690.11 CDF89028.1 - 3.7e-38 131.1 31.8 3.7e-38 131.1 22.0 2.7 2 1 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CDF89028.1 - 3.3e-16 58.9 9.1 3.3e-16 58.9 6.3 3.3 3 0 0 3 3 3 3 Sugar (and other) transporter Macro_2 PF14519.1 CDF89029.1 - 3.5e-99 331.4 0.0 4.1e-99 331.2 0.0 1.0 1 0 0 1 1 1 1 Macro-like domain Aminotran_1_2 PF00155.16 CDF89030.1 - 7.7e-85 284.9 0.0 8.8e-85 284.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II SIS PF01380.17 CDF89032.1 - 2.8e-59 198.4 0.0 2.2e-30 104.9 0.0 2.4 2 0 0 2 2 2 2 SIS domain GATase_2 PF00310.16 CDF89032.1 - 1.7e-27 96.1 0.0 4.3e-19 68.4 0.0 2.3 1 1 1 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 CDF89032.1 - 1.6e-16 60.4 0.0 3.3e-16 59.4 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 CDF89032.1 - 1e-09 38.2 0.0 2.1e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.1 CDF89032.1 - 4e-08 32.2 0.1 7e-08 31.4 0.1 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Peptidase_M18 PF02127.10 CDF89033.1 - 6.9e-139 463.0 0.0 8.3e-139 462.7 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Pkinase PF00069.20 CDF89034.1 - 1.3e-68 231.0 0.0 5.6e-68 228.8 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF89034.1 - 3.6e-33 114.7 0.0 6.4e-31 107.3 0.0 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase APH PF01636.18 CDF89034.1 - 0.00025 20.8 0.0 0.022 14.4 0.0 2.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 CDF89034.1 - 0.032 13.3 0.0 0.076 12.0 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ADH_N PF08240.7 CDF89035.1 - 2.3e-28 98.0 0.5 4.7e-28 97.1 0.4 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CDF89035.1 - 2.3e-27 95.1 0.9 3.3e-27 94.6 0.7 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CDF89035.1 - 7.4e-06 26.8 0.2 1.3e-05 26.0 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NifU PF01106.12 CDF89035.1 - 0.074 12.8 0.3 4 7.2 0.3 2.5 2 0 0 2 2 2 0 NifU-like domain Metallophos PF00149.23 CDF89036.1 - 2.4e-40 138.1 0.1 3.3e-40 137.6 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PHD PF00628.24 CDF89037.1 - 2.7e-10 39.7 7.5 4.9e-10 38.9 5.2 1.5 1 0 0 1 1 1 1 PHD-finger Sec1 PF00995.18 CDF89038.1 - 6.4e-138 460.8 13.0 7.3e-138 460.6 9.0 1.0 1 0 0 1 1 1 1 Sec1 family Glyco_transf_92 PF01697.22 CDF89038.1 - 0.0083 15.4 0.7 0.072 12.3 0.0 2.4 2 1 0 2 2 2 1 Glycosyltransferase family 92 HHH_6 PF14579.1 CDF89038.1 - 0.02 14.9 0.0 0.078 13.0 0.0 2.1 1 0 0 1 1 1 0 Helix-hairpin-helix motif GalP_UDP_transf PF01087.17 CDF89038.1 - 0.72 9.8 2.8 2.5 8.1 0.4 2.4 3 0 0 3 3 3 0 Galactose-1-phosphate uridyl transferase, N-terminal domain Prp18 PF02840.10 CDF89038.1 - 7.4 6.3 8.7 9.6 6.0 0.2 3.7 4 1 0 4 4 4 0 Prp18 domain TCO89 PF10452.4 CDF89039.1 - 1.2e-134 450.5 49.1 1.6e-91 308.0 23.0 2.1 1 1 1 2 2 2 2 TORC1 subunit TCO89 ABC2_membrane PF01061.19 CDF89040.1 - 1e-65 220.8 63.9 1.4e-40 138.6 10.2 3.1 3 0 0 3 3 3 2 ABC-2 type transporter PDR_CDR PF06422.7 CDF89040.1 - 1.1e-36 124.5 3.4 5.3e-31 106.3 0.0 3.0 2 0 0 2 2 2 2 CDR ABC transporter ABC_tran PF00005.22 CDF89040.1 - 3.4e-36 124.5 0.0 1.3e-17 64.4 0.0 2.9 3 0 0 3 3 3 2 ABC transporter ABC_trans_N PF14510.1 CDF89040.1 - 8.1e-13 48.2 2.9 6.3e-12 45.4 0.0 2.7 1 1 1 2 2 2 1 ABC-transporter extracellular N-terminal ABC2_membrane_3 PF12698.2 CDF89040.1 - 1.4e-09 37.5 14.0 1.4e-09 37.5 9.7 3.4 2 2 1 3 3 2 1 ABC-2 family transporter protein DUF258 PF03193.11 CDF89040.1 - 2.3e-05 23.6 0.0 0.00023 20.4 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_25 PF13481.1 CDF89040.1 - 8.9e-05 21.9 0.0 0.0057 16.0 0.0 3.0 3 0 0 3 3 3 1 AAA domain cobW PF02492.14 CDF89040.1 - 0.00012 21.5 0.4 0.00029 20.3 0.0 1.8 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_21 PF13304.1 CDF89040.1 - 0.00014 21.9 0.0 0.96 9.3 0.0 3.3 3 0 0 3 3 3 1 AAA domain FtsK_SpoIIIE PF01580.13 CDF89040.1 - 0.00029 20.3 0.1 0.66 9.4 0.0 2.5 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_29 PF13555.1 CDF89040.1 - 0.00034 20.0 0.3 0.021 14.3 0.1 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.1 CDF89040.1 - 0.00036 20.6 0.1 0.0051 16.9 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_16 PF13191.1 CDF89040.1 - 0.0022 17.9 4.2 0.022 14.7 0.0 3.2 4 0 0 4 4 2 1 AAA ATPase domain Miro PF08477.8 CDF89040.1 - 0.0054 17.2 0.0 2.2 8.7 0.0 2.8 2 0 0 2 2 2 1 Miro-like protein SMC_N PF02463.14 CDF89040.1 - 0.0055 15.9 0.0 0.46 9.6 0.0 3.1 3 1 0 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_18 PF13238.1 CDF89040.1 - 0.0075 16.5 0.0 0.025 14.9 0.0 1.9 2 0 0 2 2 1 1 AAA domain UPF0079 PF02367.12 CDF89040.1 - 0.0076 15.8 0.4 0.14 11.7 0.2 2.3 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_33 PF13671.1 CDF89040.1 - 0.011 15.6 0.3 0.069 13.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 CDF89040.1 - 0.035 14.9 0.0 0.16 12.7 0.0 2.1 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 CDF89040.1 - 0.045 13.7 0.0 0.5 10.3 0.0 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase Septin PF00735.13 CDF89040.1 - 0.056 12.4 0.1 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 Septin NACHT PF05729.7 CDF89040.1 - 0.067 12.8 0.7 0.36 10.4 0.1 2.4 2 0 0 2 2 2 0 NACHT domain AAA_24 PF13479.1 CDF89040.1 - 0.19 11.2 0.4 1.1 8.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.1 CDF89040.1 - 0.31 10.9 2.3 0.39 10.6 0.1 2.3 3 0 0 3 3 3 0 AAA domain Transp_cyt_pur PF02133.10 CDF89041.1 - 1.7e-164 547.5 40.2 2.1e-164 547.3 27.9 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Macro PF01661.16 CDF89042.1 - 1.8e-24 85.9 0.0 2.4e-24 85.4 0.0 1.2 1 0 0 1 1 1 1 Macro domain Chitin_synth_2 PF03142.10 CDF89043.1 - 9.5e-287 951.5 0.3 1.5e-286 950.8 0.2 1.3 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.1 CDF89043.1 - 2e-16 60.3 0.2 7.2e-16 58.4 0.1 2.0 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 CDF89043.1 - 1.7e-13 50.9 0.0 3.7e-11 43.2 0.0 2.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Cyt-b5 PF00173.23 CDF89043.1 - 8.1e-07 28.7 0.0 2.5e-06 27.2 0.0 1.9 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glyco_transf_21 PF13506.1 CDF89043.1 - 0.00036 19.8 0.0 0.0012 18.1 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.21 CDF89043.1 - 0.0013 18.4 0.0 0.031 13.9 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 Sec61_beta PF03911.11 CDF89043.1 - 9.6 6.0 14.2 0.36 10.6 2.7 2.9 2 0 0 2 2 2 0 Sec61beta family Peptidase_M20 PF01546.23 CDF89044.1 - 4.8e-24 84.9 0.0 6.3e-24 84.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 CDF89044.1 - 2.7e-09 36.7 0.0 5.1e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.12 CDF89044.1 - 0.00059 19.6 0.0 0.00096 18.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Chitin_synth_1 PF01644.12 CDF89045.1 - 7e-78 260.0 0.3 1.1e-77 259.3 0.2 1.4 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_2 PF03142.10 CDF89045.1 - 8.2e-26 90.4 6.1 1.2e-19 70.1 0.0 3.0 3 0 0 3 3 3 2 Chitin synthase Chitin_synth_1N PF08407.6 CDF89045.1 - 5.8e-23 80.3 0.1 1.7e-22 78.8 0.1 1.8 1 0 0 1 1 1 1 Chitin synthase N-terminal Glyco_trans_2_3 PF13632.1 CDF89045.1 - 6.1e-11 42.3 0.4 6.1e-11 42.3 0.3 2.0 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 CDF89045.1 - 3.9e-10 39.9 0.0 2.2e-08 34.1 0.0 2.2 2 0 0 2 2 2 1 Glycosyltransferase like family 2 SCO1-SenC PF02630.9 CDF89046.1 - 3.8e-68 228.5 0.0 4.9e-68 228.1 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.16 CDF89046.1 - 0.00012 21.8 0.0 0.00022 20.8 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family DUF4366 PF14283.1 CDF89046.1 - 0.045 13.1 0.0 0.07 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) YchF-GTPase_C PF06071.8 CDF89047.1 - 1.2e-36 124.3 0.0 3.2e-36 122.9 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.18 CDF89047.1 - 5.6e-13 48.8 0.0 1.2e-12 47.8 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.16 CDF89047.1 - 0.00017 21.3 0.0 0.00037 20.2 0.0 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.13 CDF89047.1 - 0.0037 16.5 0.0 0.0067 15.7 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.1 CDF89047.1 - 0.043 14.1 1.5 2.2 8.6 0.7 2.6 3 0 0 3 3 3 0 AAA domain SecA_PP_bind PF01043.15 CDF89047.1 - 0.1 12.9 0.2 2.9 8.2 0.0 2.3 2 0 0 2 2 2 0 SecA preprotein cross-linking domain MobB PF03205.9 CDF89047.1 - 0.16 11.7 0.4 7.2 6.3 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B KGG PF10685.4 CDF89047.1 - 3.6 7.6 5.1 67 3.5 0.0 3.3 3 0 0 3 3 3 0 Stress-induced bacterial acidophilic repeat motif EamA PF00892.15 CDF89048.1 - 3.7 7.6 23.0 0.57 10.2 3.5 3.1 3 0 0 3 3 3 0 EamA-like transporter family ADH_zinc_N PF00107.21 CDF89049.1 - 2.2e-09 36.9 0.0 3.7e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CDF89049.1 - 0.054 13.2 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Pkinase PF00069.20 CDF89050.1 - 5.5e-66 222.3 0.0 7e-66 222.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF89050.1 - 2e-34 118.8 0.0 2.8e-34 118.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 CDF89050.1 - 0.0023 18.4 1.2 0.0071 16.8 0.8 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.1 CDF89050.1 - 0.0083 15.1 0.0 0.018 14.0 0.0 1.5 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 CDF89050.1 - 0.015 15.0 0.0 1.3 8.7 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family CTP_transf_1 PF01148.15 CDF89051.1 - 5.4e-75 252.3 22.9 7e-75 252.0 15.9 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family Ribosomal_L4 PF00573.17 CDF89053.1 - 1.6e-46 158.1 2.5 2.3e-46 157.6 1.8 1.2 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.1 CDF89053.1 - 2.4e-29 101.0 0.9 6.4e-28 96.4 0.4 2.5 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Methyltransf_31 PF13847.1 CDF89054.1 - 3.4e-14 52.6 0.0 7.4e-14 51.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 CDF89054.1 - 1.2e-11 44.3 0.0 1.9e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 CDF89054.1 - 2.9e-11 43.4 0.0 5.8e-11 42.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDF89054.1 - 1.2e-10 41.9 0.0 4.5e-10 40.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDF89054.1 - 6.7e-09 36.1 0.0 2.3e-08 34.4 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDF89054.1 - 3.4e-07 30.5 0.0 8.7e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDF89054.1 - 4.8e-07 29.6 0.0 1.5e-06 28.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 CDF89054.1 - 6.1e-07 28.9 0.0 1.1e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_9 PF08003.6 CDF89054.1 - 3.7e-06 25.8 0.1 4.9e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.15 CDF89054.1 - 4.9e-06 25.8 0.0 7.4e-06 25.2 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PRMT5 PF05185.11 CDF89054.1 - 4.5e-05 22.5 0.0 5.8e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_12 PF08242.7 CDF89054.1 - 7.6e-05 23.1 0.0 0.00017 21.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 CDF89054.1 - 0.00021 20.7 0.0 0.00032 20.2 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.14 CDF89054.1 - 0.00024 21.1 0.0 0.0005 20.0 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Ubie_methyltran PF01209.13 CDF89054.1 - 0.0047 16.0 0.1 0.0084 15.2 0.1 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.1 CDF89054.1 - 0.0062 16.2 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 CDF89054.1 - 0.0075 15.8 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_2 PF00891.13 CDF89054.1 - 0.012 14.8 0.0 0.017 14.3 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase UPF0020 PF01170.13 CDF89054.1 - 0.015 14.9 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Met_10 PF02475.11 CDF89054.1 - 0.019 14.5 0.0 0.029 13.9 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_4 PF02390.12 CDF89054.1 - 0.023 13.7 0.0 0.038 13.0 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_24 PF13578.1 CDF89054.1 - 0.042 14.6 0.0 0.074 13.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.10 CDF89054.1 - 0.051 12.9 0.0 0.081 12.3 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 TehB PF03848.9 CDF89054.1 - 0.067 12.3 0.1 0.14 11.3 0.1 1.6 1 1 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_10 PF05971.7 CDF89055.1 - 2.4e-42 145.1 0.0 3.4e-42 144.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF890) MTS PF05175.9 CDF89055.1 - 8e-08 31.8 0.0 1.2e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 CDF89055.1 - 9.5e-05 21.6 0.1 0.00016 20.9 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 CDF89055.1 - 0.0031 17.5 0.0 0.0058 16.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 CDF89055.1 - 0.023 14.2 0.0 0.038 13.5 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Sld5 PF05916.6 CDF89056.1 - 3.8e-12 46.4 0.8 5.9e-12 45.8 0.6 1.3 1 0 0 1 1 1 1 GINS complex protein PIF1 PF05970.9 CDF89056.1 - 0.0065 15.4 0.1 0.028 13.3 0.0 1.8 1 1 1 2 2 2 1 PIF1-like helicase Tweety PF04906.8 CDF89056.1 - 0.015 13.7 0.0 0.019 13.3 0.0 1.1 1 0 0 1 1 1 0 Tweety DNA_pol_lambd_f PF10391.4 CDF89056.1 - 0.02 14.4 1.7 0.045 13.2 0.1 2.2 2 0 0 2 2 2 0 Fingers domain of DNA polymerase lambda PNPOx_C PF10590.4 CDF89058.1 - 3.7e-20 71.1 4.4 7.4e-20 70.1 3.0 1.5 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyridox_oxidase PF01243.15 CDF89058.1 - 1.2e-10 41.2 0.0 1.7e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.2 CDF89058.1 - 0.037 14.3 0.0 0.075 13.3 0.0 1.6 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Euplotes_phero PF05842.6 CDF89059.1 - 0.042 14.2 1.2 0.075 13.3 0.4 1.7 2 0 0 2 2 2 0 Euplotes octocarinatus mating pheromone protein DASH_Dad1 PF08649.5 CDF89060.1 - 6.4e-31 105.8 2.2 7.8e-31 105.5 1.6 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad1 UBN2 PF14223.1 CDF89060.1 - 0.0049 16.6 0.2 0.0055 16.4 0.1 1.1 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type GCR1_C PF12550.3 CDF89060.1 - 0.036 13.9 0.0 0.11 12.3 0.0 1.7 1 1 1 2 2 2 0 Transcriptional activator of glycolytic enzymes ATP-synt PF00231.14 CDF89062.1 - 1.1e-65 221.8 3.8 1.3e-65 221.6 2.6 1.0 1 0 0 1 1 1 1 ATP synthase SRC-1 PF08832.5 CDF89062.1 - 0.071 13.8 0.1 0.21 12.3 0.1 1.8 1 0 0 1 1 1 0 Steroid receptor coactivator Fig1 PF12351.3 CDF89063.1 - 1.7e-54 184.5 3.9 1.7e-54 184.5 2.7 1.9 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 Hum_adeno_E3A PF05393.6 CDF89063.1 - 0.23 11.1 0.1 0.23 11.1 0.0 2.4 3 0 0 3 3 3 0 Human adenovirus early E3A glycoprotein AMP-binding PF00501.23 CDF89064.1 - 2.4e-64 217.2 0.0 2.9e-64 217.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CDF89064.1 - 0.0015 19.4 0.0 0.0027 18.5 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Renin_r PF07850.9 CDF89064.1 - 0.11 12.8 0.0 0.32 11.3 0.0 1.7 1 0 0 1 1 1 0 Renin receptor-like protein Acyltransferase PF01553.16 CDF89065.1 - 1.6e-27 95.5 0.0 2.2e-27 95.0 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase MFS_1 PF07690.11 CDF89066.1 - 1.9e-34 118.9 18.7 1.9e-34 118.9 13.0 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily GCV_T PF01571.16 CDF89067.1 - 1.9e-60 203.8 0.0 2.6e-60 203.3 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.6 CDF89067.1 - 4.1e-16 58.7 0.0 6.8e-16 58.0 0.0 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain SoxG PF04268.7 CDF89067.1 - 0.0074 16.1 0.0 0.6 9.9 0.0 2.3 2 0 0 2 2 2 2 Sarcosine oxidase, gamma subunit family Cpn60_TCP1 PF00118.19 CDF89068.1 - 1.4e-08 33.8 0.2 6.6e-08 31.6 0.2 1.9 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family PRK PF00485.13 CDF89069.1 - 1.6e-10 40.8 0.1 2.2e-10 40.4 0.1 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family DEAD PF00270.24 CDF89070.1 - 6.2e-42 142.9 2.2 2.4e-41 141.0 1.2 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF89070.1 - 3.5e-27 94.0 0.4 1.4e-26 92.1 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.1 CDF89070.1 - 0.0005 20.2 0.1 0.0014 18.7 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CDF89070.1 - 0.0015 18.2 0.0 0.0037 16.9 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain ResIII PF04851.10 CDF89070.1 - 0.003 17.4 0.2 0.0083 15.9 0.1 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.1 CDF89070.1 - 0.012 15.1 0.6 0.042 13.4 0.4 1.8 1 1 0 1 1 1 0 AAA domain Helicase_RecD PF05127.9 CDF89070.1 - 0.016 14.8 0.0 0.032 13.8 0.0 1.5 1 0 0 1 1 1 0 Helicase SNF2_N PF00176.18 CDF89070.1 - 0.022 13.5 0.1 0.038 12.7 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain CMS1 PF14617.1 CDF89070.1 - 0.024 13.7 0.2 0.065 12.2 0.0 1.8 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Helicase_C_2 PF13307.1 CDF89070.1 - 0.052 13.5 0.0 0.3 11.0 0.0 2.3 3 0 0 3 3 3 0 Helicase C-terminal domain Flavi_DEAD PF07652.9 CDF89070.1 - 0.069 12.9 0.1 0.2 11.3 0.0 1.8 1 1 0 1 1 1 0 Flavivirus DEAD domain UvrD-helicase PF00580.16 CDF89070.1 - 0.19 11.0 2.2 0.61 9.3 1.5 1.9 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain PhoH PF02562.11 CDF89070.1 - 0.26 10.4 2.8 1 8.5 1.9 1.9 1 1 0 1 1 1 0 PhoH-like protein Atg31 PF09795.4 CDF89071.1 - 2.2e-41 141.2 6.2 2.9e-41 140.8 4.3 1.2 1 0 0 1 1 1 1 Autophagy-related protein 31 tRNA-synt_2b PF00587.20 CDF89072.1 - 6.8e-35 120.1 0.1 1.5e-34 119.0 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 CDF89072.1 - 1.7e-22 79.4 8.5 1.7e-22 79.4 5.9 1.9 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain IFT57 PF10498.4 CDF89072.1 - 0.0072 15.1 5.1 0.014 14.2 1.8 2.0 2 0 0 2 2 2 1 Intra-flagellar transport protein 57 DUF342 PF03961.8 CDF89072.1 - 0.042 12.2 3.4 0.067 11.6 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) DUF1049 PF06305.6 CDF89072.1 - 0.053 13.0 0.2 0.12 11.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) Occludin_ELL PF07303.8 CDF89072.1 - 7.6 7.3 9.1 0.52 11.0 1.5 2.4 3 0 0 3 3 3 0 Occludin homology domain DUF896 PF05979.7 CDF89073.1 - 0.037 13.6 0.1 0.69 9.5 0.0 2.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) ADH_zinc_N PF00107.21 CDF89074.1 - 1e-25 89.7 0.3 1.6e-25 89.1 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 CDF89074.1 - 1.7e-18 67.7 0.4 6.7e-18 65.7 0.1 2.1 1 1 1 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CDF89074.1 - 6.6e-10 38.7 0.0 1.7e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Semialdhyde_dh PF01118.19 CDF89074.1 - 0.007 16.6 0.1 0.024 14.9 0.1 1.9 1 1 1 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Prefoldin_2 PF01920.15 CDF89074.1 - 0.048 13.4 0.1 0.1 12.3 0.1 1.5 1 0 0 1 1 1 0 Prefoldin subunit DUF3364 PF11844.3 CDF89075.1 - 0.96 9.5 4.3 1.2 9.2 1.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3364) Ribosomal_S17 PF00366.15 CDF89076.1 - 2.3e-28 98.0 3.9 3.4e-28 97.4 2.7 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 Myb_DNA-binding PF00249.26 CDF89077.1 - 1.9e-18 66.2 11.4 7.9e-10 38.6 0.2 4.4 3 1 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CDF89077.1 - 6.1e-17 61.4 17.0 1.2e-14 54.1 0.9 4.1 4 1 0 4 4 4 2 Myb-like DNA-binding domain DUF3144 PF11342.3 CDF89077.1 - 0.066 13.2 0.3 0.23 11.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3144) MADF_DNA_bdg PF10545.4 CDF89077.1 - 0.16 12.1 15.7 0.15 12.2 1.3 3.9 3 1 0 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like DUF1752 PF08550.5 CDF89079.1 - 5.9e-09 35.3 2.1 1.3e-08 34.2 1.5 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) WD40 PF00400.27 CDF89080.1 - 6.5e-24 82.9 3.5 0.00022 21.0 0.0 5.4 5 0 0 5 5 5 5 WD domain, G-beta repeat CHCH PF06747.8 CDF89081.1 - 1.5e-09 37.5 6.9 4.1e-05 23.3 0.4 2.2 2 0 0 2 2 2 2 CHCH domain UPF0203 PF05254.7 CDF89081.1 - 3e-05 23.7 4.3 0.055 13.3 0.1 3.2 1 1 3 4 4 4 2 Uncharacterised protein family (UPF0203) Cmc1 PF08583.5 CDF89081.1 - 0.00047 19.8 7.9 0.0033 17.1 0.7 2.5 1 1 0 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like Pet191_N PF10203.4 CDF89081.1 - 0.0034 17.3 9.7 0.025 14.6 3.2 3.0 1 1 0 2 2 2 1 Cytochrome c oxidase assembly protein PET191 COX6B PF02297.12 CDF89081.1 - 0.027 14.4 6.5 0.15 12.0 2.7 2.1 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb GCK PF07802.6 CDF89081.1 - 0.059 13.4 6.5 0.64 10.1 0.3 2.4 1 1 2 3 3 3 0 GCK domain UCR_hinge PF02320.11 CDF89081.1 - 0.072 13.0 4.6 0.37 10.7 0.3 2.5 1 1 0 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein DB PF01682.14 CDF89081.1 - 0.22 11.5 10.6 1.6 8.7 1.2 2.1 1 1 0 2 2 2 0 DB module DUF1903 PF08991.5 CDF89081.1 - 0.36 11.0 6.5 1.4 9.1 0.2 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF1903) COX17 PF05051.8 CDF89081.1 - 0.84 9.7 7.6 4.6 7.3 0.1 3.3 2 1 0 3 3 3 0 Cytochrome C oxidase copper chaperone (COX17) NDUF_B7 PF05676.8 CDF89081.1 - 0.88 9.0 6.6 8 5.9 0.7 2.9 1 1 2 3 3 3 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) FMN_red PF03358.10 CDF89082.1 - 3.6e-10 39.5 0.0 4.8e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_1 PF00258.20 CDF89082.1 - 2.5e-07 30.8 0.1 4.9e-07 29.8 0.0 1.5 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_2 PF02525.12 CDF89082.1 - 0.0013 18.2 0.0 0.0018 17.8 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold GFO_IDH_MocA PF01408.17 CDF89083.1 - 5.1e-19 68.9 0.0 1.2e-18 67.7 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 CDF89083.1 - 8.9e-08 31.9 0.0 1.4e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Bac_rhodopsin PF01036.13 CDF89084.1 - 3.8e-41 140.8 17.4 5.2e-41 140.3 12.1 1.1 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein DUF4131 PF13567.1 CDF89084.1 - 3.5 7.0 10.6 4.1 6.7 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) SGL PF08450.7 CDF89085.1 - 8.5e-43 146.4 0.0 6.3e-42 143.6 0.0 2.2 1 1 1 2 2 2 1 SMP-30/Gluconolaconase/LRE-like region GalKase_gal_bdg PF10509.4 CDF89086.1 - 6.4e-20 70.1 0.1 1.4e-19 69.1 0.1 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.21 CDF89086.1 - 5.8e-13 48.6 0.1 1.2e-12 47.7 0.1 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 CDF89086.1 - 1.9e-10 40.8 0.0 3.6e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 GHMP kinases C terminal HTH_23 PF13384.1 CDF89086.1 - 0.079 12.6 0.0 0.27 10.9 0.0 1.9 2 0 0 2 2 2 0 Homeodomain-like domain Aldose_epim PF01263.15 CDF89087.1 - 3.3e-54 184.0 0.0 6e-54 183.1 0.0 1.4 1 0 0 1 1 1 1 Aldose 1-epimerase Epimerase PF01370.16 CDF89087.1 - 2.4e-47 161.3 0.0 4e-47 160.6 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Epimerase_Csub PF13950.1 CDF89087.1 - 5.3e-23 80.7 0.0 1.1e-22 79.7 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose 4-epimerase C-term subunit 3Beta_HSD PF01073.14 CDF89087.1 - 4.5e-18 64.9 0.0 6e-17 61.2 0.0 2.2 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.10 CDF89087.1 - 1.5e-13 50.3 0.0 4.1e-11 42.3 0.0 2.6 3 0 0 3 3 3 2 Polysaccharide biosynthesis protein adh_short PF00106.20 CDF89087.1 - 5.6e-11 42.6 0.0 1.1e-10 41.7 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase RmlD_sub_bind PF04321.12 CDF89087.1 - 7.7e-10 38.1 0.0 1.3e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.7 CDF89087.1 - 7.5e-08 31.5 0.0 1.2e-06 27.6 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein KR PF08659.5 CDF89087.1 - 9.3e-08 31.9 0.0 1.8e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CDF89087.1 - 2.3e-05 24.4 0.0 4.3e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding DapB_N PF01113.15 CDF89087.1 - 0.012 15.5 0.0 0.024 14.5 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus AAA PF00004.24 CDF89089.1 - 2.3e-40 137.8 0.0 4.1e-40 137.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 CDF89089.1 - 3e-06 27.4 0.2 0.00053 20.1 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.9 CDF89089.1 - 3.6e-06 26.9 0.0 9.5e-06 25.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.8 CDF89089.1 - 1.6e-05 24.0 0.0 2.8e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.9 CDF89089.1 - 0.00012 21.7 0.1 0.00083 19.0 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 CDF89089.1 - 0.00014 21.8 0.0 0.0032 17.4 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.7 CDF89089.1 - 0.00086 18.4 0.0 0.0016 17.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_28 PF13521.1 CDF89089.1 - 0.0014 18.5 0.4 0.0038 17.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.1 CDF89089.1 - 0.0026 17.6 0.0 0.0063 16.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CDF89089.1 - 0.0045 17.7 0.5 0.013 16.3 0.1 2.1 2 1 0 2 2 1 1 AAA domain IstB_IS21 PF01695.12 CDF89089.1 - 0.0057 16.0 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_25 PF13481.1 CDF89089.1 - 0.0063 15.9 1.9 0.073 12.4 0.1 2.5 2 1 1 3 3 3 1 AAA domain AAA_18 PF13238.1 CDF89089.1 - 0.0069 16.7 0.7 0.026 14.8 0.0 2.4 2 1 1 3 3 2 1 AAA domain AAA_19 PF13245.1 CDF89089.1 - 0.0074 16.0 0.5 0.016 14.9 0.3 1.5 1 0 0 1 1 1 1 Part of AAA domain Zeta_toxin PF06414.7 CDF89089.1 - 0.011 14.8 0.0 0.019 14.0 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_3 PF07726.6 CDF89089.1 - 0.011 15.2 0.0 0.028 14.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 CDF89089.1 - 0.012 15.5 0.0 0.023 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 CDF89089.1 - 0.012 15.3 0.1 0.083 12.5 0.0 2.3 2 0 0 2 2 2 0 NTPase NB-ARC PF00931.17 CDF89089.1 - 0.018 13.9 0.0 0.064 12.1 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain TIP49 PF06068.8 CDF89089.1 - 0.021 13.5 0.0 0.04 12.6 0.0 1.4 1 0 0 1 1 1 0 TIP49 C-terminus PhoH PF02562.11 CDF89089.1 - 0.03 13.5 0.2 0.2 10.8 0.1 2.1 2 0 0 2 2 2 0 PhoH-like protein RNA_helicase PF00910.17 CDF89089.1 - 0.032 14.3 0.0 0.08 13.1 0.0 1.8 1 0 0 1 1 1 0 RNA helicase KaiC PF06745.8 CDF89089.1 - 0.04 13.0 0.1 0.35 9.9 0.0 2.2 1 1 1 2 2 2 0 KaiC NACHT PF05729.7 CDF89089.1 - 0.048 13.3 0.1 0.33 10.6 0.1 2.1 1 1 1 2 2 2 0 NACHT domain Mg_chelatase PF01078.16 CDF89089.1 - 0.049 12.7 0.1 0.1 11.7 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.1 CDF89089.1 - 0.053 13.0 0.2 0.13 11.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.4 CDF89089.1 - 0.12 11.3 0.0 0.19 10.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) PP2C PF00481.16 CDF89090.1 - 9e-76 254.6 0.3 1.5e-75 253.9 0.2 1.3 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.7 CDF89090.1 - 0.00026 20.7 0.1 0.0037 17.0 0.1 2.1 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) DUF1263 PF06882.7 CDF89090.1 - 0.0087 15.6 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1263) Nitrate_red_del PF02613.10 CDF89090.1 - 0.075 12.8 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Nitrate reductase delta subunit Trp_oprn_chp PF09534.5 CDF89090.1 - 0.097 12.2 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Med2 PF11214.3 CDF89091.1 - 3e-31 107.5 10.6 3e-31 107.5 7.3 2.2 1 1 1 2 2 2 1 Mediator complex subunit 2 Borrelia_P83 PF05262.6 CDF89091.1 - 0.012 13.8 5.9 0.014 13.7 4.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF1675 PF07897.6 CDF89091.1 - 0.03 14.2 8.7 0.045 13.6 6.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1675) CDC45 PF02724.9 CDF89091.1 - 3 5.7 11.8 3.8 5.4 8.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Ycf1 PF05758.7 CDF89091.1 - 3 5.4 11.4 3.7 5.1 7.9 1.1 1 0 0 1 1 1 0 Ycf1 RR_TM4-6 PF06459.7 CDF89091.1 - 7.4 6.3 14.0 1.6 8.6 6.8 1.8 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 ATP-synt_DE_N PF02823.11 CDF89093.1 - 4.6e-19 67.9 0.0 6.9e-19 67.4 0.0 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Rad21_Rec8_N PF04825.8 CDF89094.1 - 1.6e-25 89.1 0.2 3.3e-25 88.1 0.2 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.11 CDF89094.1 - 8.3e-13 47.3 0.0 1.8e-12 46.2 0.0 1.7 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein ScpA_ScpB PF02616.9 CDF89094.1 - 0.0043 16.6 0.1 0.011 15.3 0.1 1.7 1 0 0 1 1 1 1 ScpA/B protein DRIM PF07539.7 CDF89095.1 - 2.3e-44 150.2 0.0 9.5e-44 148.2 0.0 2.2 1 0 0 1 1 1 1 Down-regulated in metastasis HEAT PF02985.17 CDF89095.1 - 0.00026 20.8 2.6 36 4.8 0.0 7.2 8 0 0 8 8 8 2 HEAT repeat HMG_box PF00505.14 CDF89096.1 - 1.9e-15 56.8 2.0 5.5e-15 55.3 1.4 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 CDF89096.1 - 5.3e-15 55.5 2.4 1.5e-14 54.0 1.7 1.9 1 0 0 1 1 1 1 HMG-box domain DUF155 PF02582.9 CDF89097.1 - 2.6e-60 203.3 1.7 4.2e-60 202.6 1.2 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 UPF0449 PF15136.1 CDF89097.1 - 0.02 15.1 0.0 0.053 13.7 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 Histone PF00125.19 CDF89098.1 - 3.8e-26 91.0 0.0 4.9e-26 90.6 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 CDF89098.1 - 4.6e-06 26.6 0.0 6.6e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 CDF89099.1 - 4.9e-21 74.6 0.3 6.7e-21 74.1 0.2 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 CDF89099.1 - 1.5e-05 24.9 0.1 3.3e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.8 CDF89099.1 - 0.0035 17.5 0.0 0.0061 16.8 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Mitofilin PF09731.4 CDF89099.1 - 0.019 13.6 2.5 0.022 13.4 1.7 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Herpes_glycop_H PF02489.11 CDF89099.1 - 0.034 12.1 0.4 0.034 12.1 0.2 1.0 1 0 0 1 1 1 0 Herpesvirus glycoprotein H DUF77 PF01910.12 CDF89100.1 - 1.1e-26 92.3 0.0 1.2e-26 92.1 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function DUF77 Trehalase PF01204.13 CDF89101.1 - 2.9e-182 606.9 0.0 3.5e-182 606.6 0.0 1.1 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.6 CDF89101.1 - 3.2e-16 58.3 0.6 5.3e-16 57.6 0.4 1.4 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain Ran_BP1 PF00638.13 CDF89102.1 - 1.7e-54 183.1 0.9 2.5e-54 182.5 0.6 1.2 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.18 CDF89102.1 - 0.0047 16.6 0.9 0.048 13.3 0.6 2.1 1 1 0 1 1 1 1 WH1 domain CDC27 PF09507.5 CDF89102.1 - 0.087 12.0 12.3 0.11 11.6 8.5 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Prenyltransf PF01255.14 CDF89103.1 - 6.6e-81 270.6 0.1 8.3e-81 270.3 0.1 1.1 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase RNaseH_C PF09293.5 CDF89103.1 - 0.01 15.7 0.1 0.021 14.7 0.0 1.6 1 0 0 1 1 1 0 T4 RNase H, C terminal polyprenyl_synt PF00348.12 CDF89104.1 - 8.4e-53 178.8 0.1 2.1e-48 164.4 0.0 3.1 2 1 0 2 2 2 2 Polyprenyl synthetase Mannosyl_trans2 PF04188.8 CDF89105.1 - 3.6e-98 329.3 36.8 5.2e-96 322.2 25.5 2.0 1 1 0 1 1 1 1 Mannosyltransferase (PIG-V)) DUF3518 PF12031.3 CDF89105.1 - 0.041 12.7 0.0 0.077 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3518) SHP PF03579.8 CDF89105.1 - 0.49 9.7 3.7 1.5 8.2 2.6 1.8 1 0 0 1 1 1 0 Small hydrophobic protein RCR PF12273.3 CDF89106.1 - 3.9e-38 130.9 0.2 5.7e-38 130.4 0.2 1.2 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red DUF2668 PF10873.3 CDF89106.1 - 0.083 13.0 0.1 2.1 8.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2668) Aldedh PF00171.17 CDF89107.1 - 7.1e-152 505.9 0.0 8e-152 505.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.6 CDF89107.1 - 1.1e-05 24.8 0.0 1.7e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1487) Rad51 PF08423.6 CDF89108.1 - 8.8e-29 100.1 0.1 6e-28 97.4 0.0 2.0 2 0 0 2 2 2 1 Rad51 AAA_25 PF13481.1 CDF89108.1 - 2e-09 37.1 0.0 8.4e-09 35.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain RecA PF00154.16 CDF89108.1 - 0.00017 20.7 0.2 0.00036 19.6 0.1 1.6 1 1 0 1 1 1 1 recA bacterial DNA recombination protein KaiC PF06745.8 CDF89108.1 - 0.00029 20.0 1.1 0.0025 16.9 0.3 2.7 2 1 0 2 2 2 1 KaiC AAA_22 PF13401.1 CDF89108.1 - 0.0018 18.3 0.2 0.073 13.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain NTP_transf_5 PF14907.1 CDF89108.1 - 0.034 13.4 0.5 4.3 6.6 0.1 2.3 2 0 0 2 2 2 0 Uncharacterised nucleotidyltransferase Maf1 PF09174.5 CDF89109.1 - 8.4e-54 182.1 3.4 1.4e-50 171.6 1.3 2.5 1 1 1 2 2 2 2 Maf1 regulator Sel1 PF08238.7 CDF89110.1 - 4.6e-10 39.7 6.8 9e-05 22.9 0.4 3.4 3 0 0 3 3 3 3 Sel1 repeat CFIA_Pcf11 PF11526.3 CDF89110.1 - 1.2 9.2 5.7 0.77 9.9 0.2 3.3 3 1 0 3 3 3 0 Subunit of cleavage factor IA Pcf11 Tcp11 PF05794.8 CDF89111.1 - 4.3e-125 417.9 1.5 6.2e-125 417.3 1.0 1.2 1 0 0 1 1 1 1 T-complex protein 11 Histone PF00125.19 CDF89112.1 - 7.8e-16 57.9 0.3 9.5e-16 57.6 0.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 CDF89112.1 - 3.3e-05 23.8 0.1 5.5e-05 23.1 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.12 CDF89112.1 - 4.2e-05 23.4 0.2 5.9e-05 22.9 0.1 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.1 CDF89112.1 - 4.8e-05 23.4 0.1 6.7e-05 22.9 0.1 1.4 1 1 0 1 1 1 1 Kinetochore component CENP-S CENP-T PF15511.1 CDF89112.1 - 0.00087 18.6 0.0 0.00092 18.5 0.0 1.0 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T Bromo_TP PF07524.8 CDF89112.1 - 0.011 15.4 0.0 0.021 14.5 0.0 1.3 1 1 0 1 1 1 0 Bromodomain associated TFIID_20kDa PF03847.8 CDF89112.1 - 0.021 15.1 0.0 0.035 14.3 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A TFIID-31kDa PF02291.10 CDF89112.1 - 0.094 12.5 0.0 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Histone PF00125.19 CDF89113.1 - 5.2e-30 103.3 0.7 8.5e-30 102.7 0.5 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 CDF89113.1 - 9.4e-07 28.9 0.0 1.4e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Kinetochore component CENP-S CBFD_NFYB_HMF PF00808.18 CDF89113.1 - 0.002 18.1 1.0 0.0025 17.8 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.8 CDF89113.1 - 0.058 13.1 0.1 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated PRAI PF00697.17 CDF89114.1 - 5.2e-55 186.0 0.0 5.8e-55 185.9 0.0 1.0 1 0 0 1 1 1 1 N-(5'phosphoribosyl)anthranilate (PRA) isomerase DeoC PF01791.4 CDF89114.1 - 0.012 14.9 0.1 2.2 7.5 0.0 2.3 2 0 0 2 2 2 0 DeoC/LacD family aldolase Pyrophosphatase PF00719.14 CDF89115.1 - 9.7e-54 181.0 0.3 1.2e-53 180.7 0.2 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase Csm1 PF12539.3 CDF89115.1 - 0.12 12.8 0.0 0.28 11.6 0.0 1.8 1 1 0 1 1 1 0 Chromosome segregation protein Csm1/Pcs1 zf-Apc11 PF12861.2 CDF89116.1 - 8.3e-43 144.1 6.9 1.1e-42 143.7 4.8 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.2 CDF89116.1 - 3.2e-29 100.8 7.4 4.6e-29 100.3 5.1 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_2 PF13639.1 CDF89116.1 - 3.8e-07 29.8 15.9 2.2e-06 27.3 11.0 2.1 1 1 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 CDF89116.1 - 0.0005 19.7 12.0 0.0098 15.6 8.7 2.2 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 CDF89116.1 - 0.0061 16.1 12.5 0.12 12.0 8.7 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CDF89116.1 - 0.016 15.0 0.9 0.016 15.0 0.6 2.3 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-HC5HC2H PF13771.1 CDF89116.1 - 0.028 14.5 6.3 0.058 13.5 4.4 1.5 1 1 0 1 1 1 0 PHD-like zinc-binding domain zf-C3HC4_2 PF13923.1 CDF89116.1 - 0.031 14.2 12.8 0.13 12.3 8.8 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-HIT PF04438.11 CDF89116.1 - 0.034 13.7 3.1 0.034 13.7 2.1 2.1 2 0 0 2 2 2 0 HIT zinc finger zf-C3HC4 PF00097.20 CDF89116.1 - 0.043 13.4 12.8 0.17 11.5 8.8 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TerY-C PF15616.1 CDF89116.1 - 0.059 13.2 3.5 0.085 12.7 2.4 1.2 1 0 0 1 1 1 0 TerY-C metal binding domain zf-RING_4 PF14570.1 CDF89116.1 - 0.12 12.0 14.0 0.73 9.4 6.0 3.0 1 1 2 3 3 3 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.3 CDF89116.1 - 0.13 12.2 12.8 0.74 9.8 8.9 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain zf-HC5HC2H_2 PF13832.1 CDF89116.1 - 0.19 11.7 6.1 0.33 10.9 4.2 1.5 1 1 0 1 1 1 0 PHD-zinc-finger like domain DZR PF12773.2 CDF89116.1 - 0.21 11.4 9.6 0.8 9.5 3.6 2.3 1 1 1 2 2 2 0 Double zinc ribbon zf-RING-like PF08746.6 CDF89116.1 - 0.74 9.8 11.2 3.2 7.8 7.8 2.1 1 1 0 1 1 1 0 RING-like domain Glutaredoxin PF00462.19 CDF89117.1 - 2.3e-16 59.5 0.0 3.6e-16 58.8 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_2 PF13098.1 CDF89117.1 - 0.017 15.2 0.3 0.055 13.6 0.0 1.9 2 1 0 2 2 2 0 Thioredoxin-like domain Thioredoxin_3 PF13192.1 CDF89117.1 - 0.048 13.4 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin domain DIM PF08194.7 CDF89117.1 - 0.89 9.5 4.0 22 5.0 0.0 2.3 2 0 0 2 2 2 0 DIM protein Mannosyl_trans3 PF11051.3 CDF89118.1 - 1.1e-87 293.8 0.0 1.5e-87 293.4 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative CYSTM PF12734.2 CDF89119.1 - 9.6e-15 54.3 10.5 9.6e-15 54.3 7.3 4.5 3 2 0 3 3 3 1 Cysteine-rich TM module stress tolerance zf-C3HC4_2 PF13923.1 CDF89120.1 - 0.00067 19.6 0.4 0.0017 18.3 0.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDF89120.1 - 0.0013 18.3 0.2 0.0039 16.8 0.1 1.8 1 0 0 1 1 1 1 zinc-RING finger domain A_deaminase PF00962.17 CDF89120.1 - 0.002 17.0 0.0 0.0036 16.2 0.0 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase zf-C3HC4_3 PF13920.1 CDF89120.1 - 0.0058 16.2 0.4 0.017 14.8 0.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDF89120.1 - 0.014 14.9 0.1 0.038 13.6 0.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CDF89120.1 - 0.38 10.6 3.0 0.17 11.7 0.1 1.8 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4_4 PF15227.1 CDF89120.1 - 1.2 9.0 3.6 0.83 9.5 0.7 2.0 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Fibrillarin PF01269.12 CDF89121.1 - 4e-110 366.1 0.0 4.9e-110 365.8 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.5 CDF89121.1 - 9.6e-06 25.2 0.0 1.6e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.14 CDF89121.1 - 0.075 12.5 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Pkinase PF00069.20 CDF89122.1 - 7.4e-40 136.7 0.0 3.5e-22 78.8 0.0 3.1 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDF89122.1 - 7.2e-15 54.7 0.0 4.5e-09 35.7 0.0 3.1 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.1 CDF89122.1 - 2.1e-05 23.6 0.0 0.78 8.6 0.0 3.3 3 0 0 3 3 3 3 Kinase-like APH PF01636.18 CDF89122.1 - 0.006 16.3 0.0 0.014 15.0 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family EMP24_GP25L PF01105.19 CDF89123.1 - 1e-30 106.8 0.0 1.2e-30 106.6 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Njmu-R1 PF15053.1 CDF89123.1 - 0.094 11.4 0.0 0.13 10.9 0.0 1.1 1 0 0 1 1 1 0 Mjmu-R1-like protein family HEAT PF02985.17 CDF89124.1 - 1.6e-22 77.5 7.6 0.00087 19.1 0.0 8.4 8 0 0 8 8 8 5 HEAT repeat HEAT_EZ PF13513.1 CDF89124.1 - 1.4e-21 76.3 0.5 6.5e-10 39.2 0.0 8.3 8 1 1 9 9 9 3 HEAT-like repeat HEAT_2 PF13646.1 CDF89124.1 - 5.4e-15 55.4 0.0 1.1e-05 25.6 0.0 5.7 4 3 3 7 7 7 6 HEAT repeats Adaptin_N PF01602.15 CDF89124.1 - 3.1e-08 32.4 6.9 0.016 13.5 0.0 4.1 4 1 1 5 5 5 2 Adaptin N terminal region Cnd1 PF12717.2 CDF89124.1 - 1.2e-05 25.1 7.3 0.023 14.5 0.0 3.9 3 1 0 3 3 3 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.2 CDF89124.1 - 0.00016 21.9 0.2 0.55 10.6 0.0 4.8 4 2 0 4 4 4 1 Vacuolar 14 Fab1-binding region IBN_N PF03810.14 CDF89124.1 - 0.011 15.6 0.3 0.2 11.5 0.0 3.2 2 1 0 2 2 2 0 Importin-beta N-terminal domain UNC45-central PF11701.3 CDF89124.1 - 0.086 12.4 3.0 2.2 7.9 0.3 3.1 2 1 0 2 2 2 0 Myosin-binding striated muscle assembly central TAFH PF07531.9 CDF89124.1 - 0.31 10.7 2.1 9.8 5.9 0.0 4.0 4 0 0 4 4 4 0 NHR1 homology to TAF TFIIF_alpha PF05793.7 CDF89124.1 - 3.4 5.9 7.2 5 5.3 5.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SH3_1 PF00018.23 CDF89125.1 - 3.2e-11 42.4 0.2 1.1e-10 40.7 0.0 2.1 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.1 CDF89125.1 - 0.00015 21.2 0.0 0.00036 20.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SAICAR_synt PF01259.13 CDF89126.1 - 6.4e-100 333.3 0.0 7.7e-100 333.0 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase UPF0086 PF01868.11 CDF89126.1 - 0.02 14.5 0.2 0.37 10.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function UPF0086 DUF2528 PF10800.3 CDF89126.1 - 0.12 12.7 0.0 0.24 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2528) Pkinase PF00069.20 CDF89127.1 - 1.8e-57 194.4 0.2 2.6e-57 193.9 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF89127.1 - 2e-32 112.3 0.0 9.1e-32 110.1 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 CDF89127.1 - 0.02 13.6 0.0 0.038 12.7 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase APH PF01636.18 CDF89127.1 - 0.059 13.0 0.1 0.15 11.7 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family ACCA PF03255.9 CDF89127.1 - 0.36 10.3 3.0 0.23 10.9 0.7 1.6 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Pkinase PF00069.20 CDF89128.1 - 1.6e-73 247.0 0.3 2.6e-73 246.3 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF89128.1 - 7e-56 189.1 0.0 1.2e-55 188.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF89128.1 - 6.3e-06 25.3 0.2 3.7e-05 22.8 0.0 2.2 3 0 0 3 3 3 1 Kinase-like Kdo PF06293.9 CDF89128.1 - 0.1 11.6 0.0 0.21 10.6 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Carn_acyltransf PF00755.15 CDF89129.1 - 1.5e-190 634.2 0.0 1.8e-190 634.0 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Oxysterol_BP PF01237.13 CDF89130.1 - 5.7e-130 432.9 0.1 9.1e-130 432.2 0.1 1.3 1 0 0 1 1 1 1 Oxysterol-binding protein Ank_5 PF13857.1 CDF89130.1 - 5.6e-14 51.8 0.0 3.1e-05 24.0 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 CDF89130.1 - 7.5e-13 48.6 0.0 7.2e-06 26.2 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 CDF89130.1 - 1.1e-10 40.7 0.0 0.00082 19.0 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 CDF89130.1 - 3.6e-09 36.8 0.0 0.0037 17.7 0.0 3.1 2 1 1 3 3 3 3 Ankyrin repeats (many copies) PH_8 PF15409.1 CDF89130.1 - 2.5e-08 33.8 0.2 5.9e-08 32.6 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.24 CDF89130.1 - 1e-07 32.0 0.1 3.6e-07 30.3 0.1 2.0 1 0 0 1 1 1 1 PH domain Ank_3 PF13606.1 CDF89130.1 - 2e-07 30.5 0.0 0.071 13.3 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat PH_11 PF15413.1 CDF89130.1 - 3.1e-06 27.3 2.3 1.4e-05 25.2 0.4 2.9 2 0 0 2 2 2 1 Pleckstrin homology domain Phos_pyr_kin PF08543.7 CDF89131.1 - 8.1e-78 261.0 0.1 1e-77 260.6 0.1 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.11 CDF89131.1 - 7.8e-63 212.0 1.6 1e-62 211.6 1.1 1.2 1 0 0 1 1 1 1 TENA/THI-4/PQQC family PfkB PF00294.19 CDF89131.1 - 1.6e-07 30.7 0.0 2.7e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase HK PF02110.10 CDF89131.1 - 0.029 13.5 0.0 0.069 12.3 0.0 1.6 1 1 0 1 1 1 0 Hydroxyethylthiazole kinase family zf-C2H2_4 PF13894.1 CDF89132.1 - 4.2e-05 23.5 5.9 0.07 13.4 0.3 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 CDF89132.1 - 0.00017 21.6 9.7 0.034 14.4 0.2 3.3 2 1 0 2 2 2 2 Zinc finger, C2H2 type BAF1_ABF1 PF04684.8 CDF89132.1 - 6.5 5.4 21.3 0.012 14.5 7.5 1.8 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor His_Phos_1 PF00300.17 CDF89133.1 - 2e-40 138.4 0.0 1.1e-39 136.0 0.0 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Arginosuc_synth PF00764.14 CDF89134.1 - 5.9e-160 532.5 0.0 6.9e-160 532.3 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.8 CDF89134.1 - 1.5e-05 24.3 0.0 2.6e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.16 CDF89134.1 - 2.4e-05 23.9 0.0 3.4e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase tRNA_Me_trans PF03054.11 CDF89134.1 - 0.0021 16.7 0.0 0.003 16.1 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase NAD_Gly3P_dh_N PF01210.18 CDF89135.1 - 3.6e-52 176.2 0.1 7.9e-52 175.1 0.0 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.9 CDF89135.1 - 7.2e-48 162.0 0.1 1.2e-47 161.3 0.1 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus Semialdhyde_dh PF01118.19 CDF89135.1 - 0.042 14.1 0.1 0.53 10.5 0.1 2.3 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain RNA_Me_trans PF04252.8 CDF89136.1 - 4.5e-77 257.9 0.0 5e-77 257.7 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase PRP3 PF08572.5 CDF89137.1 - 1.9e-59 200.7 20.1 3.2e-59 200.0 14.0 1.4 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.7 CDF89137.1 - 2.7e-32 111.1 0.1 2.7e-32 111.1 0.1 2.3 3 1 0 3 3 3 1 Protein of unknown function (DUF1115) Arf PF00025.16 CDF89139.1 - 1.5e-27 95.9 0.0 7.9e-27 93.6 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family Ras PF00071.17 CDF89139.1 - 1.3e-12 47.4 0.0 1.7e-12 47.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDF89139.1 - 1.3e-10 41.7 0.0 1.4e-09 38.4 0.0 2.1 2 0 0 2 2 2 1 Miro-like protein MMR_HSR1 PF01926.18 CDF89139.1 - 2.1e-08 34.0 0.0 3.2e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.15 CDF89139.1 - 5e-08 32.0 0.3 4.7e-06 25.5 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.5 CDF89139.1 - 3.8e-06 26.2 0.0 5.3e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.7 CDF89139.1 - 4.2e-05 22.7 0.0 5.6e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 CDF89139.1 - 0.00011 21.7 0.0 0.011 15.1 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.12 CDF89139.1 - 0.00021 20.8 0.2 0.063 12.8 0.0 2.1 1 1 1 2 2 2 2 Conserved hypothetical ATP binding protein Dynamin_N PF00350.18 CDF89139.1 - 0.0019 18.0 0.1 0.026 14.3 0.0 2.1 2 0 0 2 2 2 1 Dynamin family FeoB_N PF02421.13 CDF89139.1 - 0.023 13.9 0.3 0.052 12.8 0.2 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_17 PF13207.1 CDF89139.1 - 0.055 14.2 0.0 0.082 13.7 0.0 1.6 1 1 0 1 1 1 0 AAA domain MobB PF03205.9 CDF89139.1 - 0.058 13.0 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B DUF2470 PF10615.4 CDF89140.1 - 5.3e-07 29.7 0.0 8e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) Pkinase PF00069.20 CDF89141.1 - 2.2e-77 259.7 0.1 3.9e-77 258.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF89141.1 - 4.1e-38 130.9 0.0 6.4e-38 130.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase UBA_2 PF08587.6 CDF89141.1 - 2.7e-21 75.5 1.8 3.7e-21 75.0 0.2 2.1 2 0 0 2 2 2 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.1 CDF89141.1 - 1.1e-10 41.0 0.0 2.5e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.17 CDF89141.1 - 4.1e-05 23.0 0.7 9e-05 21.8 0.5 1.5 1 0 0 1 1 1 1 RIO1 family YukC PF10140.4 CDF89141.1 - 6.9e-05 21.5 0.2 0.00015 20.4 0.2 1.5 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC Kdo PF06293.9 CDF89141.1 - 0.0053 15.8 0.1 0.01 14.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CDF89141.1 - 0.011 15.5 0.1 0.72 9.5 0.1 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family SIR2 PF02146.12 CDF89142.1 - 1.1e-34 119.7 0.0 4.2e-21 75.4 0.0 2.3 2 0 0 2 2 2 2 Sir2 family SeleniumBinding PF11524.3 CDF89142.1 - 0.13 12.4 0.1 5.4 7.2 0.0 2.4 2 0 0 2 2 2 0 Selenium binding protein c-SKI_SMAD_bind PF08782.5 CDF89142.1 - 0.62 10.2 6.5 0.21 11.7 1.8 2.2 2 1 1 3 3 3 0 c-SKI Smad4 binding domain Rpr2 PF04032.11 CDF89143.1 - 4.3e-11 42.5 0.3 4.3e-11 42.5 0.2 1.7 2 0 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-ribbon_3 PF13248.1 CDF89143.1 - 0.011 14.9 1.1 0.22 10.7 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 CDF89143.1 - 0.021 14.3 0.8 0.22 11.0 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain DZR PF12773.2 CDF89143.1 - 0.027 14.2 1.7 0.081 12.7 1.2 1.8 1 1 0 1 1 1 0 Double zinc ribbon DUF2799 PF10973.3 CDF89143.1 - 0.11 12.5 0.5 0.3 11.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2799) zf-HIT PF04438.11 CDF89143.1 - 0.2 11.3 1.9 8.2 6.1 0.1 2.4 2 0 0 2 2 2 0 HIT zinc finger zinc_ribbon_5 PF13719.1 CDF89143.1 - 0.45 10.1 1.8 0.74 9.4 0.0 2.1 2 0 0 2 2 2 0 zinc-ribbon domain Pex24p PF06398.6 CDF89144.1 - 1.1e-80 271.1 4.7 1.3e-80 270.8 3.3 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin WD40 PF00400.27 CDF89145.1 - 1.6e-07 30.8 11.3 0.00014 21.6 0.0 5.5 6 0 0 6 6 6 2 WD domain, G-beta repeat PQQ_2 PF13360.1 CDF89145.1 - 0.014 14.8 0.3 4.9 6.5 0.1 2.8 1 1 2 3 3 3 0 PQQ-like domain PQQ PF01011.16 CDF89145.1 - 0.096 12.2 0.5 0.58 9.7 0.0 2.6 4 0 0 4 4 4 0 PQQ enzyme repeat PQQ_3 PF13570.1 CDF89145.1 - 0.59 10.4 3.7 21 5.5 0.0 3.9 4 0 0 4 4 4 0 PQQ-like domain SET PF00856.23 CDF89146.1 - 3.4e-08 33.9 0.0 1.5e-07 31.8 0.0 2.0 1 1 0 1 1 1 1 SET domain TPR_11 PF13414.1 CDF89147.1 - 9.6e-53 175.7 28.3 6e-17 61.0 0.2 6.3 5 1 1 6 6 6 6 TPR repeat TPR_1 PF00515.23 CDF89147.1 - 6.1e-43 142.7 18.6 1e-07 31.2 0.1 9.6 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.12 CDF89147.1 - 1.2e-33 112.2 22.6 0.00029 20.5 0.1 9.4 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_12 PF13424.1 CDF89147.1 - 4.2e-24 84.2 12.2 9.7e-11 41.4 0.3 5.7 4 1 1 5 5 5 5 Tetratricopeptide repeat TPR_16 PF13432.1 CDF89147.1 - 1.2e-20 73.5 10.6 0.00053 20.5 0.0 6.7 3 3 3 6 6 6 6 Tetratricopeptide repeat TPR_14 PF13428.1 CDF89147.1 - 1e-18 66.1 11.0 0.24 12.1 0.0 9.8 5 3 5 10 10 9 4 Tetratricopeptide repeat TPR_8 PF13181.1 CDF89147.1 - 3.4e-18 63.9 17.1 0.0038 16.8 0.1 9.0 8 1 1 9 9 9 4 Tetratricopeptide repeat TPR_19 PF14559.1 CDF89147.1 - 2.7e-17 62.8 12.9 0.0035 17.6 0.1 7.1 4 3 3 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.1 CDF89147.1 - 2e-12 45.9 9.9 0.004 16.8 0.0 7.7 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.1 CDF89147.1 - 1.6e-10 40.6 0.2 0.00064 19.5 0.0 5.0 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.1 CDF89147.1 - 2.1e-10 39.9 10.8 2.6 8.4 0.0 8.7 8 1 0 8 8 8 3 Tetratricopeptide repeat Apc3 PF12895.2 CDF89147.1 - 2.3e-08 34.0 12.6 0.0024 17.9 1.4 4.3 3 1 2 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 CDF89147.1 - 9.3e-08 32.0 15.1 0.14 12.7 0.0 8.1 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_10 PF13374.1 CDF89147.1 - 0.0022 17.8 0.3 1.3e+02 2.6 0.0 5.5 5 0 0 5 5 5 0 Tetratricopeptide repeat SHNi-TPR PF10516.4 CDF89147.1 - 0.0029 16.8 9.2 4.5 6.5 0.1 6.6 7 0 0 7 7 7 1 SHNi-TPR DUF3808 PF10300.4 CDF89147.1 - 0.003 16.2 0.5 0.003 16.2 0.3 3.0 2 1 1 3 3 3 1 Protein of unknown function (DUF3808) TPR_20 PF14561.1 CDF89147.1 - 0.88 9.7 10.5 6.6 6.9 0.1 5.2 4 3 2 6 6 6 0 Tetratricopeptide repeat XPC-binding PF09280.6 CDF89147.1 - 5.5 6.5 8.4 1.3 8.5 1.5 2.9 2 2 0 2 2 2 0 XPC-binding domain MFS_1 PF07690.11 CDF89148.1 - 7.7e-29 100.4 32.1 7.7e-29 100.4 22.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily AAA_2 PF07724.9 CDF89149.1 - 2.4e-51 174.0 1.4 1.8e-49 167.9 0.0 2.9 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.4 CDF89149.1 - 8.9e-25 86.4 0.1 4e-24 84.3 0.1 2.3 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.24 CDF89149.1 - 2.9e-22 79.2 0.1 2.4e-11 43.9 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CDF89149.1 - 9.2e-17 61.0 0.9 5.3e-12 45.6 0.0 4.2 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 CDF89149.1 - 2.2e-14 53.8 2.9 0.00027 20.9 0.0 4.5 3 2 2 5 5 5 3 AAA ATPase domain AAA_22 PF13401.1 CDF89149.1 - 7.1e-10 39.1 0.3 0.0004 20.5 0.0 3.6 4 1 0 4 4 2 2 AAA domain AAA_14 PF13173.1 CDF89149.1 - 1.6e-07 31.2 0.0 0.024 14.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.21 CDF89149.1 - 5.3e-07 29.2 0.1 3.2e-05 23.4 0.0 2.8 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_17 PF13207.1 CDF89149.1 - 1.1e-06 29.4 4.9 0.015 16.1 0.0 3.9 4 1 0 4 4 3 2 AAA domain IstB_IS21 PF01695.12 CDF89149.1 - 2.6e-06 26.9 0.1 0.043 13.2 0.0 3.0 3 0 0 3 3 3 2 IstB-like ATP binding protein Arch_ATPase PF01637.13 CDF89149.1 - 2.6e-06 27.3 13.3 0.0004 20.1 0.5 5.0 3 2 0 3 3 3 1 Archaeal ATPase AAA_18 PF13238.1 CDF89149.1 - 2.2e-05 24.7 6.6 0.065 13.5 0.1 3.8 4 0 0 4 4 3 2 AAA domain ABC_tran PF00005.22 CDF89149.1 - 5.9e-05 23.3 0.4 0.095 12.9 0.0 3.6 3 1 0 3 3 3 1 ABC transporter NACHT PF05729.7 CDF89149.1 - 0.00017 21.2 0.0 0.095 12.3 0.0 2.6 2 0 0 2 2 2 1 NACHT domain LacI PF00356.16 CDF89149.1 - 0.00018 21.0 0.0 0.061 12.9 0.0 3.2 3 0 0 3 3 2 1 Bacterial regulatory proteins, lacI family Zeta_toxin PF06414.7 CDF89149.1 - 0.00019 20.5 0.0 0.0023 17.0 0.0 2.6 2 1 0 2 2 2 1 Zeta toxin AAA_19 PF13245.1 CDF89149.1 - 0.00022 20.8 0.0 0.89 9.3 0.0 2.6 2 0 0 2 2 2 2 Part of AAA domain MobB PF03205.9 CDF89149.1 - 0.00034 20.3 0.0 0.31 10.7 0.0 2.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_28 PF13521.1 CDF89149.1 - 0.00043 20.2 0.0 0.41 10.5 0.0 3.2 3 0 0 3 3 2 1 AAA domain DUF258 PF03193.11 CDF89149.1 - 0.0005 19.2 0.0 0.13 11.4 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function, DUF258 MMR_HSR1 PF01926.18 CDF89149.1 - 0.00061 19.7 0.3 0.11 12.4 0.0 3.2 3 1 0 3 3 2 1 50S ribosome-binding GTPase RNA_helicase PF00910.17 CDF89149.1 - 0.00075 19.6 0.0 1.1 9.4 0.0 3.2 2 1 0 2 2 2 1 RNA helicase AAA_29 PF13555.1 CDF89149.1 - 0.00084 18.8 0.0 0.19 11.2 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_30 PF13604.1 CDF89149.1 - 0.00094 18.8 0.0 0.71 9.4 0.0 3.0 2 0 0 2 2 2 1 AAA domain T2SE PF00437.15 CDF89149.1 - 0.0011 17.8 0.4 0.05 12.4 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein Mg_chelatase PF01078.16 CDF89149.1 - 0.0012 18.0 0.3 0.63 9.1 0.0 3.5 3 1 0 3 3 3 1 Magnesium chelatase, subunit ChlI PduV-EutP PF10662.4 CDF89149.1 - 0.0015 17.9 0.0 0.46 9.9 0.0 2.8 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation UPF0079 PF02367.12 CDF89149.1 - 0.0056 16.3 0.0 1.5 8.4 0.0 2.6 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 SRP54 PF00448.17 CDF89149.1 - 0.0086 15.5 0.0 1.1 8.6 0.0 2.8 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain TrwB_AAD_bind PF10412.4 CDF89149.1 - 0.011 14.4 0.0 0.84 8.1 0.0 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Torsin PF06309.6 CDF89149.1 - 0.015 15.2 0.0 0.038 13.8 0.0 1.6 1 0 0 1 1 1 0 Torsin p450 PF00067.17 CDF89149.1 - 0.015 13.8 0.0 0.033 12.7 0.0 1.4 1 0 0 1 1 1 0 Cytochrome P450 PhoH PF02562.11 CDF89149.1 - 0.018 14.3 0.0 2.5 7.2 0.0 2.7 2 0 0 2 2 2 0 PhoH-like protein AAA_3 PF07726.6 CDF89149.1 - 0.02 14.4 0.1 0.68 9.5 0.0 3.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.1 CDF89149.1 - 0.025 14.5 5.6 7.7 6.3 0.0 4.2 4 1 0 5 5 5 0 AAA domain ATP_bind_1 PF03029.12 CDF89149.1 - 0.04 13.4 0.1 3.7 7.0 0.0 2.9 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein AAA_6 PF12774.2 CDF89149.1 - 0.049 13.1 0.0 13 5.2 0.0 2.5 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region D1 AAA_33 PF13671.1 CDF89149.1 - 0.057 13.3 0.1 3.9 7.3 0.0 2.9 3 0 0 3 3 2 0 AAA domain ResIII PF04851.10 CDF89149.1 - 0.071 12.9 5.2 2.4 7.9 0.0 3.9 3 1 1 4 4 4 0 Type III restriction enzyme, res subunit AAA_25 PF13481.1 CDF89149.1 - 0.087 12.2 3.8 6.2 6.1 0.1 3.3 3 2 0 3 3 2 0 AAA domain AAA_10 PF12846.2 CDF89149.1 - 0.16 11.3 1.8 1.4 8.2 0.0 3.2 3 1 1 4 4 3 0 AAA-like domain PilJ PF13675.1 CDF89149.1 - 0.18 12.1 1.6 1.5 9.2 0.8 2.5 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term APG6 PF04111.7 CDF89149.1 - 0.36 9.8 7.0 0.8 8.6 4.9 1.6 1 0 0 1 1 1 0 Autophagy protein Apg6 AAA_23 PF13476.1 CDF89149.1 - 1 9.6 19.6 1.9 8.7 0.1 3.5 2 2 0 2 2 2 0 AAA domain IncA PF04156.9 CDF89149.1 - 3.6 7.1 15.3 2.8 7.5 7.9 2.4 2 0 0 2 2 2 0 IncA protein TPR_MLP1_2 PF07926.7 CDF89149.1 - 8.9 6.0 15.8 2.5 7.8 8.0 2.4 2 1 0 2 2 1 0 TPR/MLP1/MLP2-like protein Apc13p PF05839.6 CDF89150.1 - 8.7e-11 41.6 1.0 6.3e-10 38.8 0.5 2.2 2 1 0 2 2 2 1 Apc13p protein Cellulase PF00150.13 CDF89151.1 - 9.4e-12 44.7 1.0 2.2e-11 43.5 0.7 1.5 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Herpes_gE PF02480.11 CDF89151.1 - 0.0041 15.4 0.1 0.0055 15.0 0.0 1.1 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E PalH PF08733.5 CDF89152.1 - 5.9e-60 202.9 10.8 7.7e-60 202.5 7.5 1.1 1 0 0 1 1 1 1 PalH/RIM21 DUF1129 PF06570.6 CDF89152.1 - 0.081 12.2 1.5 2.2 7.5 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1129) HLH PF00010.21 CDF89154.1 - 8.1e-19 67.0 0.2 2.7e-18 65.4 0.1 2.0 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain ABC2_membrane_2 PF12679.2 CDF89154.1 - 0.065 12.0 0.0 0.13 11.1 0.0 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein PAT1 PF09770.4 CDF89154.1 - 0.42 8.7 47.6 1.2 7.3 3.4 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 GHMP_kinases_N PF00288.21 CDF89155.1 - 1e-12 47.9 0.0 2.2e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 CDF89155.1 - 3.8e-05 23.8 0.0 9.2e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal ATP-synt_C PF00137.16 CDF89156.1 - 9.5e-27 92.7 25.5 4.2e-17 61.7 5.6 2.2 2 0 0 2 2 2 2 ATP synthase subunit C Oxidored_q2 PF00420.19 CDF89156.1 - 1.9 8.1 8.6 8.6 6.0 4.8 2.6 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L PC_rep PF01851.17 CDF89157.1 - 8.2e-25 85.6 12.0 3.3e-06 27.0 0.1 9.6 9 0 0 9 9 9 6 Proteasome/cyclosome repeat DPPIV_N PF00930.16 CDF89158.1 - 5e-97 324.6 4.1 7.4e-97 324.0 2.8 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.16 CDF89158.1 - 2.7e-50 170.5 1.4 4.4e-50 169.8 1.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CDF89158.1 - 2.9e-10 40.0 0.1 1e-09 38.3 0.1 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CDF89158.1 - 1.6e-05 24.9 0.2 0.00016 21.6 0.1 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 CDF89158.1 - 0.075 12.5 0.0 0.18 11.3 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 CDF89158.1 - 0.086 12.2 0.0 7.8 5.8 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase OST3_OST6 PF04756.8 CDF89158.1 - 0.16 11.4 0.0 2.3 7.7 0.0 2.2 2 0 0 2 2 2 0 OST3 / OST6 family PIF1 PF05970.9 CDF89159.1 - 2.4e-51 174.7 1.2 5.5e-41 140.7 0.2 2.5 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.1 CDF89159.1 - 5.3e-18 65.3 0.0 9.7e-18 64.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CDF89159.1 - 5.5e-06 26.5 0.1 2.4e-05 24.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain Herpes_Helicase PF02689.9 CDF89159.1 - 0.00012 20.0 0.3 0.001 16.9 0.0 2.0 2 0 0 2 2 2 1 Helicase T2SE PF00437.15 CDF89159.1 - 0.0009 18.2 0.0 0.0014 17.5 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein Viral_helicase1 PF01443.13 CDF89159.1 - 0.0012 18.4 0.1 0.57 9.6 0.0 2.7 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.1 CDF89159.1 - 0.0015 18.1 0.5 0.0048 16.6 0.4 1.8 1 0 0 1 1 1 1 Part of AAA domain UvrD_C_2 PF13538.1 CDF89159.1 - 0.0054 16.8 0.0 0.32 11.1 0.0 2.7 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_16 PF13191.1 CDF89159.1 - 0.0076 16.2 1.1 0.26 11.2 0.1 2.9 2 1 1 3 3 3 1 AAA ATPase domain Ins134_P3_kin PF05770.6 CDF89159.1 - 0.012 14.6 0.0 0.022 13.7 0.0 1.4 1 0 0 1 1 1 0 Inositol 1, 3, 4-trisphosphate 5/6-kinase DUF2075 PF09848.4 CDF89159.1 - 0.014 14.4 0.0 0.023 13.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) PhoH PF02562.11 CDF89159.1 - 0.016 14.4 0.0 0.044 13.0 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein AAA PF00004.24 CDF89159.1 - 0.02 15.0 0.0 0.046 13.9 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.16 CDF89159.1 - 0.053 12.6 0.0 0.12 11.5 0.0 1.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI MatE PF01554.13 CDF89160.1 - 1.2e-63 213.5 26.2 1.9e-33 115.4 5.9 2.3 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.1 CDF89160.1 - 0.00049 19.9 1.6 0.00049 19.9 1.1 4.2 5 0 0 5 5 5 2 Polysaccharide biosynthesis C-terminal domain Ribosomal_L1 PF00687.16 CDF89161.1 - 9.3e-41 139.5 0.4 9.3e-41 139.5 0.3 1.5 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family DUF3530 PF12048.3 CDF89161.1 - 0.012 14.6 0.4 0.025 13.5 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Elf1 PF05129.8 CDF89162.1 - 7.9e-31 105.5 1.7 1e-30 105.2 1.2 1.1 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like CDC45 PF02724.9 CDF89162.1 - 0.056 11.4 7.7 0.062 11.3 5.3 1.1 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.5 CDF89162.1 - 0.063 12.3 6.2 0.054 12.5 4.3 1.2 1 0 0 1 1 1 0 BUD22 Ribosomal_L37ae PF01780.14 CDF89162.1 - 0.068 13.0 1.4 0.1 12.4 1.0 1.2 1 0 0 1 1 1 0 Ribosomal L37ae protein family eIF-3c_N PF05470.7 CDF89162.1 - 0.089 10.8 1.8 0.078 11.0 1.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus zf-C2H2_6 PF13912.1 CDF89162.1 - 0.37 10.7 0.3 0.37 10.7 0.2 2.2 3 0 0 3 3 3 0 C2H2-type zinc finger DUF4611 PF15387.1 CDF89162.1 - 1.6 8.9 15.5 0.21 11.7 0.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) SDA1 PF05285.7 CDF89162.1 - 2.4 7.3 15.8 2.8 7.1 11.0 1.1 1 0 0 1 1 1 0 SDA1 COX5A PF02284.11 CDF89163.1 - 1.8e-49 166.1 1.5 2.5e-49 165.7 1.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va EIF_2_alpha PF07541.7 CDF89163.1 - 0.13 11.9 0.6 0.96 9.1 0.4 2.2 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit Calcipressin PF04847.7 CDF89164.1 - 1.7e-14 53.8 0.1 4.3e-14 52.4 0.1 1.6 1 1 0 1 1 1 1 Calcipressin FSH1 PF03959.8 CDF89165.1 - 8.9e-61 205.0 0.0 1e-60 204.8 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.2 CDF89165.1 - 1.4e-05 24.8 0.0 2.2e-05 24.2 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 CDF89165.1 - 0.0088 15.5 0.0 1.4 8.2 0.0 2.5 3 0 0 3 3 3 2 Phospholipase/Carboxylesterase Peptidase_M1 PF01433.15 CDF89167.1 - 1.5e-144 481.9 1.1 2.1e-144 481.4 0.8 1.2 1 0 0 1 1 1 1 Peptidase family M1 ERAP1_C PF11838.3 CDF89167.1 - 5.3e-91 305.2 6.1 5.8e-91 305.0 3.4 1.7 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 CDF89167.1 - 1.4e-20 73.6 0.3 3.5e-20 72.3 0.2 1.7 1 0 0 1 1 1 1 Peptidase MA superfamily HEAT_2 PF13646.1 CDF89167.1 - 0.035 14.3 0.1 4.5 7.6 0.0 2.8 2 1 0 2 2 2 0 HEAT repeats ODR4-like PF14778.1 CDF89167.1 - 0.037 12.7 0.0 0.066 11.9 0.0 1.3 1 0 0 1 1 1 0 Olfactory receptor 4-like Inositol_P PF00459.20 CDF89168.1 - 2.6e-62 210.5 0.0 3e-62 210.4 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Molybdop_Fe4S4 PF04879.11 CDF89169.1 - 0.14 11.9 0.0 0.41 10.4 0.0 1.7 2 0 0 2 2 2 0 Molybdopterin oxidoreductase Fe4S4 domain Bac_export_3 PF01313.14 CDF89169.1 - 0.4 10.3 1.8 1.2 8.9 0.5 2.2 2 0 0 2 2 2 0 Bacterial export proteins, family 3 RNase_H2-Ydr279 PF09468.5 CDF89170.1 - 2.6e-51 174.6 0.2 3.1e-51 174.3 0.1 1.0 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) RNase_PH PF01138.16 CDF89171.1 - 1.3e-18 67.6 0.0 2e-18 67.0 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 CDF89171.1 - 1.6e-10 40.7 0.0 5.3e-10 39.0 0.0 1.9 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 CcmH PF03918.9 CDF89172.1 - 0.034 13.1 0.1 0.034 13.1 0.0 1.5 2 0 0 2 2 2 0 Cytochrome C biogenesis protein HAD_2 PF13419.1 CDF89173.1 - 1.3e-11 45.0 0.0 1.8e-11 44.5 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 CDF89173.1 - 0.00011 21.8 0.0 0.00037 20.1 0.0 1.9 2 0 0 2 2 2 1 HAD-hyrolase-like HAD PF12710.2 CDF89173.1 - 0.00012 22.2 0.0 0.00015 22.0 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CDF89173.1 - 0.0035 17.7 0.0 0.29 11.5 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF155 PF02582.9 CDF89174.1 - 1.5e-44 151.9 0.1 2.1e-44 151.5 0.1 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 FAD_binding_1 PF00667.15 CDF89175.1 - 3.9e-65 219.3 0.0 5.9e-65 218.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.20 CDF89175.1 - 6.7e-29 100.7 0.9 1.2e-28 99.9 0.6 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.16 CDF89175.1 - 1e-20 74.3 0.1 3e-20 72.8 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Spore_IV_A PF09547.5 CDF89175.1 - 0.0035 16.1 0.0 0.0055 15.4 0.0 1.2 1 0 0 1 1 1 1 Stage IV sporulation protein A (spore_IV_A) Flavodoxin_5 PF12724.2 CDF89175.1 - 0.028 14.4 0.1 0.12 12.4 0.0 2.1 2 1 0 2 2 2 0 Flavodoxin domain Cas_APE2256 PF09651.5 CDF89175.1 - 0.12 12.0 0.1 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_APE2256) MAGE PF01454.14 CDF89176.1 - 9.8e-33 113.1 0.1 1.2e-32 112.8 0.0 1.1 1 0 0 1 1 1 1 MAGE family Inositol_P PF00459.20 CDF89177.1 - 2.9e-72 243.2 0.0 3.3e-72 243.0 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family DUF836 PF05768.9 CDF89178.1 - 9.7e-17 61.0 0.4 1.1e-16 60.8 0.3 1.0 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.19 CDF89178.1 - 0.00086 19.2 0.0 0.0014 18.5 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_2 PF13098.1 CDF89178.1 - 0.039 14.1 0.1 0.041 14.0 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin-like domain SapB_1 PF05184.10 CDF89178.1 - 0.21 11.4 1.8 0.52 10.1 0.2 2.3 3 0 0 3 3 3 0 Saposin-like type B, region 1 IncA PF04156.9 CDF89179.1 - 1.6 8.2 107.0 0.026 14.0 12.7 7.1 1 1 4 6 6 6 0 IncA protein DUF1788 PF08747.6 CDF89179.1 - 3.1 7.6 10.1 0.27 11.0 0.3 4.3 3 1 1 4 4 4 0 Domain of unknown function (DUF1788) TipAS PF07739.8 CDF89179.1 - 6.4 7.1 24.3 0.23 11.8 2.6 5.2 3 2 1 4 4 4 0 TipAS antibiotic-recognition domain PAP2 PF01569.16 CDF89180.1 - 5.5e-21 74.5 2.2 5.5e-21 74.5 1.5 2.2 1 1 2 3 3 3 1 PAP2 superfamily MerC PF03203.9 CDF89180.1 - 0.036 14.4 2.1 0.11 12.8 0.1 2.5 2 1 0 2 2 2 0 MerC mercury resistance protein YndJ PF14158.1 CDF89180.1 - 0.066 12.2 1.5 0.51 9.3 0.0 2.3 3 0 0 3 3 3 0 YndJ-like protein O-antigen_lig PF13425.1 CDF89180.1 - 0.34 10.8 7.5 1 9.3 0.5 3.1 1 1 1 3 3 3 0 O-antigen ligase like membrane protein MFS_1 PF07690.11 CDF89180.1 - 2.2 6.9 7.6 0.15 10.7 1.4 1.8 2 1 0 2 2 2 0 Major Facilitator Superfamily HGTP_anticodon2 PF12745.2 CDF89181.1 - 7.3e-94 313.9 0.4 7.3e-94 313.9 0.3 3.2 3 0 0 3 3 3 1 Anticodon binding domain of tRNAs Pkinase PF00069.20 CDF89181.1 - 2.9e-65 219.9 11.9 1.3e-46 158.9 0.1 5.5 4 1 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.12 CDF89181.1 - 1.6e-34 119.1 0.2 2.7e-21 75.8 0.0 3.6 3 0 0 3 3 3 3 Protein tyrosine kinase RWD PF05773.17 CDF89181.1 - 7.7e-16 57.9 4.0 3.4e-15 55.9 2.8 2.2 1 0 0 1 1 1 1 RWD domain tRNA-synt_His PF13393.1 CDF89181.1 - 2.9e-15 56.1 0.7 5.1e-15 55.3 0.0 1.8 2 0 0 2 2 2 1 Histidyl-tRNA synthetase APH PF01636.18 CDF89181.1 - 0.00088 19.0 0.0 0.0019 17.9 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Med20 PF08612.6 CDF89182.1 - 2.8e-39 134.5 0.0 3.1e-39 134.4 0.0 1.0 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex CTD_bind PF04818.8 CDF89183.1 - 1e-19 70.4 0.3 3e-19 69.0 0.2 1.9 1 0 0 1 1 1 1 RNA polymerase II-binding domain. DUF1313 PF07011.6 CDF89183.1 - 0.027 14.1 2.8 0.11 12.1 0.5 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1313) Glutaredoxin2_C PF04399.8 CDF89183.1 - 0.055 13.0 0.6 0.13 11.8 0.4 1.6 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain CTK3 PF12243.3 CDF89183.1 - 0.1 12.2 3.3 0.098 12.2 0.5 2.1 2 0 0 2 2 2 0 CTD kinase subunit gamma CTK3 DEAD PF00270.24 CDF89184.1 - 4e-25 88.2 0.1 6.9e-23 80.9 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase DUF1998 PF09369.5 CDF89184.1 - 2.3e-16 60.1 0.1 8.2e-16 58.3 0.1 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.26 CDF89184.1 - 3.7e-11 42.7 0.0 1.1e-10 41.1 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDF89184.1 - 3e-06 27.2 0.3 1.7e-05 24.7 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF1870 PF08965.5 CDF89184.1 - 0.02 14.5 0.0 0.067 12.8 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1870) PhoH PF02562.11 CDF89184.1 - 0.032 13.4 0.1 1.7 7.8 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein CDT1 PF08839.6 CDF89184.1 - 0.062 13.2 3.1 0.21 11.5 2.1 1.9 1 1 0 1 1 1 0 DNA replication factor CDT1 like SRX PF09201.5 CDF89185.1 - 1.4e-52 177.2 0.0 2.6e-52 176.4 0.0 1.4 1 0 0 1 1 1 1 SRX SRP54 PF00448.17 CDF89185.1 - 1.3e-46 158.5 0.5 3.3e-44 150.6 0.1 2.6 2 1 0 2 2 2 1 SRP54-type protein, GTPase domain SRP54_N PF02881.14 CDF89185.1 - 5.8e-06 26.3 0.7 1.9e-05 24.6 0.1 2.3 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain CbiA PF01656.18 CDF89185.1 - 9.6e-06 25.1 0.0 1.9e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain SRP-alpha_N PF04086.8 CDF89185.1 - 1.3e-05 24.6 2.1 2.5e-05 23.8 1.4 1.4 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal ArgK PF03308.11 CDF89185.1 - 9.1e-05 21.3 1.1 0.0004 19.2 0.0 2.4 2 1 0 2 2 2 1 ArgK protein MobB PF03205.9 CDF89185.1 - 0.002 17.8 0.3 0.0079 15.9 0.0 2.1 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B ArsA_ATPase PF02374.10 CDF89185.1 - 0.0064 15.5 0.2 0.063 12.3 0.2 2.2 1 1 0 1 1 1 1 Anion-transporting ATPase Zeta_toxin PF06414.7 CDF89185.1 - 0.0083 15.2 0.0 0.021 13.9 0.0 1.7 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.1 CDF89185.1 - 0.0096 16.0 0.3 0.18 11.9 0.0 3.0 1 1 2 3 3 3 1 AAA domain AAA_16 PF13191.1 CDF89185.1 - 0.024 14.6 0.0 0.058 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.1 CDF89185.1 - 0.084 12.7 0.1 0.32 10.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain NAD_binding_10 PF13460.1 CDF89185.1 - 0.086 12.8 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 NADH(P)-binding DUF87 PF01935.12 CDF89185.1 - 5.7 6.6 7.0 1.5 8.5 0.3 3.0 4 0 0 4 4 4 0 Domain of unknown function DUF87 Cyt-b5 PF00173.23 CDF89186.1 - 3.8e-14 52.2 0.0 8.2e-14 51.1 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.19 CDF89186.1 - 7.5e-09 35.4 10.7 1.2e-08 34.7 7.4 1.4 1 0 0 1 1 1 1 Fatty acid desaturase zf-HIT PF04438.11 CDF89187.1 - 4.9e-09 35.6 9.5 4.9e-09 35.6 6.6 2.2 2 0 0 2 2 2 1 HIT zinc finger V-ATPase_G PF03179.10 CDF89188.1 - 3.7e-29 101.1 8.9 4.1e-29 100.9 6.2 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF3164 PF11363.3 CDF89188.1 - 0.0011 18.3 2.0 0.0014 18.0 1.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3164) Aminotran_5 PF00266.14 CDF89188.1 - 0.065 11.9 0.2 0.077 11.7 0.1 1.2 1 0 0 1 1 1 0 Aminotransferase class-V ATP-synt_B PF00430.13 CDF89188.1 - 0.14 11.9 12.1 0.039 13.7 5.1 1.9 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) Phasin PF05597.6 CDF89188.1 - 0.2 11.3 5.6 0.27 10.9 3.9 1.1 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF3552 PF12072.3 CDF89188.1 - 0.21 10.7 10.7 0.077 12.2 5.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) DFF40 PF09230.5 CDF89188.1 - 0.33 10.2 2.0 0.39 10.0 1.4 1.0 1 0 0 1 1 1 0 DNA fragmentation factor 40 kDa GA PF01468.12 CDF89188.1 - 1.1 9.4 10.2 0.13 12.3 3.3 2.2 2 1 0 2 2 2 0 GA module HAUS6_N PF14661.1 CDF89188.1 - 1.6 8.0 7.2 18 4.5 3.2 2.0 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus KfrA_N PF11740.3 CDF89188.1 - 3.5 8.0 7.0 2.1 8.7 3.5 1.6 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term Aldedh PF00171.17 CDF89189.1 - 1.5e-122 409.2 0.0 1.8e-122 409.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family RRF PF01765.14 CDF89190.1 - 1.3e-37 128.8 7.0 2.2e-37 128.0 4.8 1.4 1 0 0 1 1 1 1 Ribosome recycling factor BCDHK_Adom3 PF10436.4 CDF89190.1 - 0.026 14.0 1.4 0.25 10.8 0.9 2.6 1 1 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase Phage_GPO PF05929.6 CDF89190.1 - 0.069 12.3 5.6 0.29 10.3 0.6 2.1 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase YqaJ PF09588.5 CDF89190.1 - 0.13 12.2 1.0 0.22 11.4 0.7 1.6 1 1 0 1 1 1 0 YqaJ-like viral recombinase domain FliD_C PF07195.7 CDF89190.1 - 0.17 11.1 8.7 0.33 10.2 6.0 1.6 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus Mnd1 PF03962.10 CDF89190.1 - 0.56 9.8 9.5 0.076 12.6 2.9 2.0 2 0 0 2 2 2 0 Mnd1 family eIF3_N PF09440.5 CDF89190.1 - 1.3 9.2 8.3 0.31 11.2 2.1 2.1 2 0 0 2 2 2 0 eIF3 subunit 6 N terminal domain RGS PF00615.14 CDF89190.1 - 1.3 9.1 5.4 1.3 9.1 1.7 2.3 2 1 0 2 2 2 0 Regulator of G protein signaling domain DUF4446 PF14584.1 CDF89190.1 - 1.7 8.4 6.5 1.1 9.0 1.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) RNB PF00773.14 CDF89191.1 - 1.2e-56 192.4 0.1 2.6e-56 191.2 0.0 1.6 1 0 0 1 1 1 1 RNB domain OB_RNB PF08206.6 CDF89191.1 - 0.0069 15.8 0.0 4.6 6.8 0.0 2.6 2 0 0 2 2 2 2 Ribonuclease B OB domain SlyX PF04102.7 CDF89191.1 - 0.045 14.1 4.9 0.18 12.2 3.4 2.1 1 0 0 1 1 1 0 SlyX Prp19 PF08606.6 CDF89191.1 - 0.33 10.6 4.3 1.2 8.9 3.0 2.0 1 0 0 1 1 1 0 Prp19/Pso4-like Aldedh PF00171.17 CDF89192.1 - 4.2e-98 328.6 0.0 5.2e-98 328.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Brr6_like_C_C PF10104.4 CDF89193.1 - 3.1e-39 133.5 1.1 4.3e-39 133.1 0.8 1.2 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain Pyridoxal_deC PF00282.14 CDF89194.1 - 9.2e-25 86.8 0.0 1.5e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain DegT_DnrJ_EryC1 PF01041.12 CDF89194.1 - 2.7e-07 29.9 0.0 4.3e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.14 CDF89194.1 - 4e-07 29.1 0.0 1.1e-06 27.6 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class-V SLA_LP_auto_ag PF05889.8 CDF89194.1 - 0.08 11.3 0.0 0.13 10.6 0.0 1.3 1 0 0 1 1 1 0 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) DUF1744 PF08490.7 CDF89194.1 - 0.2 10.2 0.0 0.38 9.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1744) HDA2-3 PF11496.3 CDF89195.1 - 5.3e-79 265.1 0.6 5.3e-79 265.1 0.4 1.9 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 MerR-DNA-bind PF09278.6 CDF89195.1 - 0.45 10.9 5.7 1.7 9.0 0.3 3.0 2 0 0 2 2 2 0 MerR, DNA binding DUF972 PF06156.8 CDF89195.1 - 1.6 9.0 22.0 0.88 9.9 2.7 4.1 1 1 3 4 4 4 0 Protein of unknown function (DUF972) DUF948 PF06103.6 CDF89195.1 - 1.8 8.4 8.3 2.6 7.9 0.4 3.2 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Reo_sigmaC PF04582.7 CDF89195.1 - 2.8 7.0 6.0 6.5 5.8 0.1 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein CHASE3 PF05227.8 CDF89195.1 - 2.8 7.6 13.0 3.8 7.2 0.2 3.0 1 1 1 2 2 2 0 CHASE3 domain IncA PF04156.9 CDF89195.1 - 7.1 6.1 32.7 0.05 13.1 13.5 2.6 1 1 1 2 2 2 0 IncA protein DivIC PF04977.10 CDF89195.1 - 8.8 5.8 21.2 1.7 8.2 0.7 4.4 3 1 1 4 4 4 0 Septum formation initiator Sec23_trunk PF04811.10 CDF89196.1 - 3.7e-13 49.4 0.2 5.4e-13 48.8 0.2 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.7 CDF89196.1 - 2e-07 31.4 0.0 5e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.10 CDF89196.1 - 8.6e-06 25.1 0.3 3.9e-05 23.0 0.1 2.1 1 1 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.10 CDF89196.1 - 0.0067 15.9 4.6 0.017 14.7 3.2 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Mhr1 PF12829.2 CDF89197.1 - 3.3e-37 126.2 2.1 3.3e-37 126.2 1.4 1.8 2 0 0 2 2 2 1 Transcriptional regulation of mitochondrial recombination FA_hydroxylase PF04116.8 CDF89198.1 - 1e-16 61.3 8.2 1e-16 61.3 5.7 2.5 3 1 0 3 3 3 1 Fatty acid hydroxylase superfamily OSCP PF00213.13 CDF89199.1 - 6.9e-45 152.9 1.3 7.9e-45 152.8 0.9 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit Pam16 PF03656.8 CDF89200.1 - 1.1e-42 144.8 2.0 1.3e-42 144.6 1.4 1.0 1 0 0 1 1 1 1 Pam16 Pkinase PF00069.20 CDF89201.1 - 3.8e-55 186.8 0.2 7.3e-53 179.3 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDF89201.1 - 2.2e-27 95.7 0.3 2.8e-25 88.8 0.1 2.9 2 1 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.6 CDF89201.1 - 0.00084 18.2 0.0 0.0015 17.3 0.0 1.3 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase DUF2718 PF10918.3 CDF89201.1 - 0.61 10.1 7.1 2 8.4 3.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2718) DUF1212 PF06738.7 CDF89202.1 - 9.1e-50 168.8 12.4 7.8e-46 155.9 0.9 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1212) DUF3815 PF12821.2 CDF89202.1 - 1.2e-26 93.1 10.6 1.2e-26 93.1 7.4 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3815) Peptidase_A8 PF01252.13 CDF89202.1 - 0.005 16.4 0.8 0.013 15.1 0.6 1.6 1 0 0 1 1 1 1 Signal peptidase (SPase) II DUF2919 PF11143.3 CDF89202.1 - 0.058 13.2 2.2 0.12 12.2 1.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2919) BP28CT PF08146.7 CDF89203.1 - 1.5e-42 144.8 2.7 1.5e-42 144.8 1.9 3.6 3 0 0 3 3 3 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.3 CDF89203.1 - 4.3e-21 75.0 1.4 4.3e-21 75.0 1.0 4.3 6 0 0 6 6 6 1 U3 small nucleolar RNA-associated protein 10 HEAT_EZ PF13513.1 CDF89203.1 - 0.044 14.2 3.1 1.8 9.1 0.3 4.9 6 0 0 6 6 6 0 HEAT-like repeat UNC-50 PF05216.8 CDF89204.1 - 9.9e-88 293.2 24.5 1.2e-87 292.9 17.0 1.0 1 0 0 1 1 1 1 UNC-50 family PLDc PF00614.17 CDF89206.1 - 2.1e-16 59.0 0.5 5.4e-08 32.3 0.2 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.1 CDF89206.1 - 3.7e-11 42.8 0.1 3.3e-07 30.1 0.0 2.9 2 0 0 2 2 2 2 PLD-like domain PX PF00787.19 CDF89206.1 - 6.6e-06 25.8 0.5 0.00027 20.6 0.2 3.2 2 0 0 2 2 2 1 PX domain ANTH PF07651.11 CDF89207.1 - 3.8e-64 216.0 0.0 3.8e-64 216.0 0.0 2.3 2 0 0 2 2 2 1 ANTH domain ENTH PF01417.15 CDF89207.1 - 9.4e-08 31.9 0.0 3.3e-07 30.2 0.0 2.0 1 0 0 1 1 1 1 ENTH domain HlyD_2 PF12700.2 CDF89207.1 - 4.9 6.2 26.5 37 3.3 18.9 1.9 2 0 0 2 2 2 0 HlyD family secretion protein BNR PF02012.15 CDF89208.1 - 3.2e-10 38.2 16.4 0.55 10.2 0.4 8.0 7 0 0 7 7 7 5 BNR/Asp-box repeat Mo-co_dimer PF03404.11 CDF89208.1 - 0.00011 21.8 0.2 10 5.7 0.0 4.9 5 0 0 5 5 5 1 Mo-co oxidoreductase dimerisation domain PSII_BNR PF14870.1 CDF89208.1 - 0.0034 16.4 0.6 13 4.6 0.0 4.0 4 1 0 4 4 4 2 Photosynthesis system II assembly factor YCF48 DUP PF00674.13 CDF89209.1 - 8.1e-31 106.1 13.5 2.2e-17 62.9 0.2 3.0 2 1 1 3 3 3 2 DUP family YjgP_YjgQ PF03739.9 CDF89209.1 - 0.019 13.7 2.1 0.66 8.6 0.0 2.1 2 0 0 2 2 2 0 Predicted permease YjgP/YjgQ family O-antigen_lig PF13425.1 CDF89209.1 - 0.056 13.4 0.1 0.62 10.0 0.0 2.3 2 0 0 2 2 2 0 O-antigen ligase like membrane protein DUF1622 PF07784.6 CDF89209.1 - 0.057 13.0 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1622) DUF4153 PF13687.1 CDF89209.1 - 0.067 12.7 3.5 1.8 7.9 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4153) DUF368 PF04018.8 CDF89209.1 - 0.089 11.9 1.5 0.31 10.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF368) DUF3953 PF13129.1 CDF89209.1 - 2 8.0 4.6 2.1 8.0 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3953) MPC PF03650.8 CDF89210.1 - 1.9e-46 156.8 0.1 2.2e-46 156.6 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0041) 4HBT_3 PF13622.1 CDF89211.1 - 6.8e-33 114.4 0.2 8.4e-33 114.1 0.2 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.10 CDF89211.1 - 2.1e-28 98.5 0.0 3.4e-22 78.4 0.0 3.1 2 1 1 3 3 3 3 Acyl-CoA thioesterase ATP-grasp_2 PF08442.5 CDF89213.1 - 1.4e-73 246.6 0.4 2.3e-73 245.8 0.3 1.4 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.14 CDF89213.1 - 1.4e-26 92.9 0.2 1.6e-25 89.5 0.1 2.6 3 0 0 3 3 3 1 CoA-ligase ATP-grasp_5 PF13549.1 CDF89213.1 - 0.00043 19.5 0.2 0.0011 18.2 0.1 1.8 1 1 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.14 CDF89213.1 - 0.0015 18.1 0.0 0.0052 16.3 0.0 1.8 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain zf-ZPR1 PF03367.8 CDF89213.1 - 0.091 11.9 0.1 0.18 10.9 0.1 1.4 1 0 0 1 1 1 0 ZPR1 zinc-finger domain Oxidored_FMN PF00724.15 CDF89214.1 - 1.9e-113 378.9 0.0 2.2e-113 378.7 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family RWD PF05773.17 CDF89215.1 - 1e-18 67.2 10.1 6.8e-18 64.6 7.0 2.3 1 1 0 1 1 1 1 RWD domain DUF2096 PF09869.4 CDF89215.1 - 0.015 15.1 1.5 0.022 14.6 1.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2096) CDC37_N PF03234.9 CDF89215.1 - 0.18 12.0 5.1 0.18 12.1 1.3 2.2 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding ENTH PF01417.15 CDF89216.1 - 5.7e-32 110.2 0.3 1.3e-31 109.0 0.2 1.6 1 0 0 1 1 1 1 ENTH domain BBP1_N PF15271.1 CDF89216.1 - 0.093 13.1 7.2 0.13 12.6 4.5 1.6 1 1 0 1 1 1 0 Spindle pole body component BBP1, Mps2-binding protein DUF2756 PF10956.3 CDF89216.1 - 0.28 11.4 5.9 0.59 10.4 1.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2756) Pro_isomerase PF00160.16 CDF89217.1 - 1.4e-45 155.3 0.0 1.5e-45 155.1 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RNA_polI_A14 PF08203.6 CDF89218.1 - 3.1e-20 72.1 0.0 4.9e-20 71.5 0.0 1.3 1 0 0 1 1 1 1 Yeast RNA polymerase I subunit RPA14 Semialdhyde_dhC PF02774.13 CDF89219.1 - 1e-42 146.0 0.0 1.6e-42 145.4 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.19 CDF89219.1 - 5.1e-32 110.7 0.0 9.5e-32 109.8 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DXP_reductoisom PF02670.11 CDF89219.1 - 0.019 15.5 0.0 0.049 14.1 0.0 1.8 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Saccharop_dh PF03435.13 CDF89219.1 - 0.057 12.3 0.3 0.11 11.4 0.0 1.6 2 0 0 2 2 2 0 Saccharopine dehydrogenase Ldh_1_N PF00056.18 CDF89219.1 - 0.12 12.2 0.1 0.29 10.9 0.0 1.8 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain Methyltransf_16 PF10294.4 CDF89220.1 - 3.6e-06 26.5 0.6 0.0037 16.7 0.0 2.3 1 1 0 2 2 2 2 Putative methyltransferase SAC3_GANP PF03399.11 CDF89221.1 - 3.2e-53 180.3 0.8 3.2e-53 180.3 0.5 2.0 2 0 0 2 2 2 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family SAC3 PF12209.3 CDF89221.1 - 1.5e-12 47.4 3.3 4.9e-12 45.8 2.3 2.0 1 0 0 1 1 1 1 Leucine permease transcriptional regulator helical domain Nha1_C PF08619.5 CDF89222.1 - 2.4e-79 267.6 44.3 1.7e-78 264.8 30.7 2.2 1 1 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Na_H_Exchanger PF00999.16 CDF89222.1 - 3.8e-78 262.6 22.8 4.6e-78 262.4 15.8 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TPR_11 PF13414.1 CDF89223.1 - 1.4e-06 27.8 1.0 0.071 12.7 0.1 3.3 3 0 0 3 3 3 2 TPR repeat TPR_2 PF07719.12 CDF89223.1 - 3.5e-05 23.3 0.1 0.64 10.0 0.0 3.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.1 CDF89223.1 - 9.8e-05 22.2 0.0 0.21 11.8 0.2 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat Apc3 PF12895.2 CDF89223.1 - 0.00033 20.7 1.0 1.4 9.1 0.1 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 CDF89223.1 - 0.00038 20.7 0.1 0.0057 16.9 0.1 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 CDF89223.1 - 0.015 15.2 0.0 0.69 9.8 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.1 CDF89223.1 - 0.029 14.1 0.7 7.9 6.5 0.2 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.23 CDF89223.1 - 0.056 13.0 0.0 4.2 7.1 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.1 CDF89223.1 - 0.074 13.7 0.1 2.2 9.1 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat SH3_1 PF00018.23 CDF89224.1 - 9.1e-14 50.5 0.7 1.9e-13 49.5 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.1 CDF89224.1 - 6.5e-12 44.8 0.0 1.5e-11 43.6 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 CDF89224.1 - 1.8e-06 27.2 0.0 3.5e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF1990 PF09348.5 CDF89226.1 - 0.052 13.1 0.0 0.095 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1990) Pro_dh PF01619.13 CDF89227.1 - 4.6e-62 209.8 0.0 6.1e-62 209.4 0.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase DUF3480 PF11979.3 CDF89227.1 - 0.074 11.6 0.1 0.16 10.5 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3480) ATP_bind_4 PF01902.12 CDF89228.1 - 3.7e-31 108.1 0.0 1.5e-30 106.2 0.0 1.9 1 1 0 1 1 1 1 ATP-binding region Ribonuc_L-PSP PF01042.16 CDF89228.1 - 7.7e-16 57.9 0.0 3.5e-09 36.4 0.0 2.5 2 0 0 2 2 2 2 Endoribonuclease L-PSP DUF2783 PF10932.3 CDF89228.1 - 0.042 13.3 0.0 3.1 7.3 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2783) DUF658 PF04936.7 CDF89229.1 - 0.078 12.8 0.4 0.15 11.9 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF658) CAP_N PF01213.14 CDF89229.1 - 8 5.6 11.9 0.14 11.4 2.5 2.0 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Sec1 PF00995.18 CDF89230.1 - 2.2e-96 323.7 0.3 2.6e-96 323.5 0.2 1.1 1 0 0 1 1 1 1 Sec1 family Glyco_hydro_81 PF03639.8 CDF89231.1 - 2.8e-238 792.4 6.3 3.2e-238 792.2 4.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 DUF4477 PF14780.1 CDF89232.1 - 0.0035 16.7 4.1 0.77 9.0 0.0 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4477) DRIM PF07539.7 CDF89232.1 - 0.042 13.2 0.1 0.1 12.0 0.1 1.7 1 0 0 1 1 1 0 Down-regulated in metastasis Spermine_synth PF01564.12 CDF89233.1 - 1.1e-88 296.2 0.0 1.7e-88 295.7 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_18 PF12847.2 CDF89233.1 - 9.6e-05 22.9 0.0 0.00017 22.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDF89233.1 - 0.00027 20.6 0.0 0.00086 19.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain DUF43 PF01861.11 CDF89233.1 - 0.0015 17.6 0.0 0.0022 17.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF43 NAD_binding_7 PF13241.1 CDF89233.1 - 0.0028 17.8 0.2 0.097 12.9 0.1 2.8 2 1 0 2 2 2 1 Putative NAD(P)-binding Methyltransf_12 PF08242.7 CDF89233.1 - 0.028 14.8 0.1 0.071 13.5 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_26 PF13659.1 CDF89233.1 - 0.04 13.9 0.0 0.087 12.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_3 PF01596.12 CDF89233.1 - 0.094 11.7 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase CPSF_A PF03178.10 CDF89234.1 - 0.00031 19.9 0.4 0.0013 17.9 0.0 2.2 2 1 0 2 2 2 1 CPSF A subunit region WD40 PF00400.27 CDF89234.1 - 0.00052 19.8 5.9 2.6 8.0 1.9 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat Sec5 PF15469.1 CDF89236.1 - 2.3e-50 170.8 8.2 2.3e-50 170.8 5.7 2.5 2 0 0 2 2 2 1 Exocyst complex component Sec5 LSM PF01423.17 CDF89237.1 - 9.8e-14 50.6 0.5 1.2e-13 50.3 0.4 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 CDF89237.1 - 0.018 14.9 0.2 0.022 14.6 0.1 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Tail_tube PF10618.4 CDF89237.1 - 0.12 12.0 0.1 0.15 11.8 0.1 1.1 1 0 0 1 1 1 0 Phage tail tube protein Pep3_Vps18 PF05131.9 CDF89238.1 - 2.3e-38 130.9 0.2 6.6e-38 129.4 0.1 1.8 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Vps39_2 PF10367.4 CDF89238.1 - 2.6e-06 27.5 0.6 2.6e-06 27.5 0.4 2.4 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.15 CDF89238.1 - 4.1e-06 26.4 2.2 4.1e-06 26.4 1.6 2.9 2 0 0 2 2 2 1 Region in Clathrin and VPS zf-RING_2 PF13639.1 CDF89238.1 - 1.6e-05 24.6 3.4 4.8e-05 23.1 2.4 1.9 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 CDF89238.1 - 0.0056 16.7 0.1 0.02 14.9 0.1 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 CDF89238.1 - 0.0062 16.1 1.7 0.018 14.6 1.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDF89238.1 - 0.0067 16.1 8.9 0.018 14.7 6.2 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-Apc11 PF12861.2 CDF89238.1 - 0.02 14.7 0.2 0.05 13.4 0.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.1 CDF89238.1 - 0.023 14.6 1.0 0.023 14.6 0.7 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) TFIID_30kDa PF03540.8 CDF89239.1 - 9.5e-27 92.5 0.1 1.4e-26 92.0 0.1 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit CDC37_N PF03234.9 CDF89240.1 - 1e-63 214.8 8.2 1e-63 214.8 5.7 3.3 2 1 2 4 4 4 1 Cdc37 N terminal kinase binding CDC37_M PF08565.6 CDF89240.1 - 2.4e-47 160.6 9.3 2.4e-47 160.6 6.5 2.7 4 0 0 4 4 4 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.5 CDF89240.1 - 1.6e-23 82.4 4.7 1.6e-23 82.4 3.3 2.7 3 0 0 3 3 3 1 Cdc37 C terminal domain DUF2415 PF10313.4 CDF89241.1 - 4.4e-22 77.4 3.3 6.1e-22 77.0 0.3 2.4 2 0 0 2 2 2 1 Uncharacterised protein domain (DUF2415) Stb3 PF10330.4 CDF89242.1 - 7.9e-33 112.0 0.1 1.5e-32 111.0 0.0 1.5 1 0 0 1 1 1 1 Putative Sin3 binding protein Stm1_N PF09598.5 CDF89243.1 - 1.5e-16 60.7 5.2 1.5e-16 60.7 3.6 4.1 4 1 0 4 4 4 1 Stm1 PDE6_gamma PF04868.7 CDF89243.1 - 0.043 13.6 2.9 0.11 12.3 0.5 2.4 2 0 0 2 2 2 0 Retinal cGMP phosphodiesterase, gamma subunit NUDIX PF00293.23 CDF89244.1 - 5.2e-16 58.5 0.0 8.7e-16 57.7 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain AMP-binding PF00501.23 CDF89246.1 - 2.7e-88 296.1 0.1 3.3e-88 295.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CDF89246.1 - 8.6e-18 65.0 0.0 2.4e-17 63.6 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Sec7 PF01369.15 CDF89247.1 - 3.1e-67 225.9 0.3 1e-66 224.2 0.2 2.0 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.2 CDF89247.1 - 5.4e-52 175.6 4.3 5.4e-52 175.6 3.0 3.7 5 0 0 5 5 5 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.5 CDF89247.1 - 5.9e-27 93.0 0.4 5.9e-27 93.0 0.2 4.1 5 0 0 5 5 5 1 Domain of unknown function (DUF1981) GTP_CH_N PF12471.3 CDF89248.1 - 4e-85 284.3 0.0 6.2e-85 283.7 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.15 CDF89248.1 - 1.8e-17 63.0 0.0 2.8e-17 62.4 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase II HSP20 PF00011.16 CDF89249.1 - 4.2e-10 39.3 0.1 8.2e-10 38.4 0.1 1.5 1 0 0 1 1 1 1 Hsp20/alpha crystallin family PcfK PF14058.1 CDF89249.1 - 0.13 12.3 0.1 0.13 12.3 0.1 2.4 3 0 0 3 3 3 0 PcfK-like protein GTP_EFTU PF00009.22 CDF89250.1 - 2.2e-45 154.4 0.0 6.7e-45 152.8 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 CDF89250.1 - 5.2e-24 84.2 0.3 5.2e-24 84.2 0.2 2.4 3 0 0 3 3 3 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 CDF89250.1 - 2.1e-07 30.9 0.2 6.3e-07 29.4 0.2 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 CDF89250.1 - 0.0015 18.4 0.0 0.007 16.3 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase Med13_C PF06333.7 CDF89250.1 - 0.83 8.1 7.2 1.3 7.4 5.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal Draxin PF15550.1 CDF89250.1 - 1.9 8.0 13.9 3.2 7.3 9.6 1.3 1 0 0 1 1 1 0 Draxin FAM176 PF14851.1 CDF89250.1 - 3.5 7.2 6.2 9.4 5.8 4.3 1.7 1 0 0 1 1 1 0 FAM176 family RR_TM4-6 PF06459.7 CDF89250.1 - 6.2 6.6 19.4 12 5.6 13.5 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 IPK PF03770.11 CDF89251.1 - 1.6e-55 187.8 0.8 2e-55 187.5 0.5 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase Vpu PF00558.14 CDF89251.1 - 0.48 10.0 1.8 1.4 8.5 0.6 2.0 2 0 0 2 2 2 0 Vpu protein fn2 PF00040.14 CDF89252.1 - 0.1 12.6 1.8 0.24 11.4 1.2 1.7 1 0 0 1 1 1 0 Fibronectin type II domain adh_short PF00106.20 CDF89254.1 - 1.1e-23 84.0 0.0 3.5e-23 82.3 0.1 1.7 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.1 CDF89254.1 - 1.6e-21 77.1 0.0 2e-21 76.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CDF89254.1 - 1.2e-10 41.4 0.0 3.6e-10 39.8 0.0 1.7 2 0 0 2 2 2 1 KR domain 3Beta_HSD PF01073.14 CDF89254.1 - 1.3e-05 24.1 0.1 3.2e-05 22.7 0.0 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 CDF89254.1 - 2e-05 24.1 0.1 9e-05 22.0 0.1 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.12 CDF89254.1 - 0.015 14.1 0.0 0.044 12.6 0.0 1.6 1 1 0 2 2 2 0 RmlD substrate binding domain Transp_cyt_pur PF02133.10 CDF89255.1 - 5e-82 275.8 29.4 6e-82 275.5 20.4 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin FAD_binding_7 PF03441.9 CDF89256.1 - 2.6e-84 282.7 0.0 4.2e-84 282.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.13 CDF89256.1 - 1.3e-26 93.3 0.1 2.9e-26 92.1 0.1 1.6 1 0 0 1 1 1 1 DNA photolyase Herpes_pp38 PF04846.8 CDF89256.1 - 0.11 11.8 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus pp38 phosphoprotein Aminotran_5 PF00266.14 CDF89257.1 - 4.2e-19 68.5 0.0 5.2e-19 68.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 CDF89257.1 - 0.0036 16.3 0.0 0.0057 15.6 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Pyridoxal_deC PF00282.14 CDF89257.1 - 0.036 12.5 0.0 0.055 11.9 0.0 1.3 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain Zn_clus PF00172.13 CDF89259.1 - 0.00044 20.1 8.9 0.00082 19.2 6.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PALP PF00291.20 CDF89261.1 - 4.4e-59 200.1 0.0 5.2e-59 199.9 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Aminotran_1_2 PF00155.16 CDF89261.1 - 0.023 13.6 0.0 0.079 11.8 0.0 1.8 2 0 0 2 2 2 0 Aminotransferase class I and II PEP-utilizers PF00391.18 CDF89261.1 - 0.15 11.6 0.6 19 4.8 0.1 2.5 2 0 0 2 2 2 0 PEP-utilising enzyme, mobile domain DAGK_cat PF00781.19 CDF89261.1 - 0.25 10.7 1.4 0.45 9.9 0.2 2.0 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain Sir1 PF11603.3 CDF89262.1 - 4.8e-13 49.3 0.3 6.6e-11 42.4 0.0 2.8 2 1 0 2 2 2 2 Regulatory protein Sir1 ATG2_CAD PF13329.1 CDF89263.1 - 1.9e-32 111.9 1.7 1.9e-32 111.9 1.1 3.1 3 0 0 3 3 3 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.6 CDF89263.1 - 1.3e-24 86.1 0.0 2.7e-24 85.1 0.0 1.6 1 0 0 1 1 1 1 ATG C terminal domain LIM PF00412.17 CDF89264.1 - 1.4e-35 121.1 55.1 1.9e-15 56.6 4.6 4.4 4 0 0 4 4 4 4 LIM domain RhoGAP PF00620.22 CDF89264.1 - 2.2e-35 121.4 0.0 8e-35 119.6 0.0 2.0 2 0 0 2 2 2 1 RhoGAP domain Met_asp_mut_E PF06368.6 CDF89264.1 - 0.029 12.5 0.1 0.044 11.9 0.1 1.2 1 0 0 1 1 1 0 Methylaspartate mutase E chain (MutE) G6PD_C PF02781.11 CDF89265.1 - 1.8e-125 417.6 0.0 2.3e-125 417.2 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.17 CDF89265.1 - 6.5e-62 209.0 0.0 2.9e-61 206.8 0.0 2.0 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Fe_hyd_lg_C PF02906.9 CDF89266.1 - 1.3e-62 211.6 0.0 1.7e-62 211.2 0.0 1.1 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain MtrE PF04206.7 CDF89266.1 - 0.15 11.0 0.0 0.23 10.4 0.0 1.2 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit E Peptidase_C1_2 PF03051.10 CDF89267.1 - 3.3e-164 546.5 0.2 3.8e-164 546.3 0.1 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.18 CDF89267.1 - 0.00011 22.2 0.1 0.29 10.9 0.0 2.4 2 0 0 2 2 2 2 Papain family cysteine protease Peptidase_S8 PF00082.17 CDF89268.1 - 1.6e-55 188.2 0.7 1.6e-55 188.2 0.5 1.7 2 0 0 2 2 2 1 Subtilase family P_proprotein PF01483.15 CDF89268.1 - 2.1e-23 81.9 0.6 4.1e-23 80.9 0.4 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain Ytp1 PF10355.4 CDF89269.1 - 2e-80 269.8 13.0 3.8e-80 268.9 9.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) Ninjurin PF04923.7 CDF89269.1 - 0.18 11.5 3.7 0.26 11.0 0.3 2.7 2 1 0 2 2 2 0 Ninjurin Med16 PF11635.3 CDF89270.1 - 3.6e-198 660.0 8.6 4.3e-198 659.8 6.0 1.0 1 0 0 1 1 1 1 Mediator complex subunit 16 Peptidase_U4 PF03419.8 CDF89270.1 - 0.012 14.7 0.2 0.019 14.0 0.1 1.3 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Hormone_2 PF00123.15 CDF89270.1 - 0.18 11.6 0.9 3.3 7.6 0.0 3.1 3 0 0 3 3 3 0 Peptide hormone Globin PF00042.17 CDF89271.1 - 3.7e-07 30.4 0.2 1.8e-06 28.2 0.1 2.2 2 1 0 2 2 2 1 Globin SRP-alpha_N PF04086.8 CDF89271.1 - 1.9 7.8 11.2 0.039 13.3 2.7 1.7 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal Globin PF00042.17 CDF89273.1 - 2.1e-06 28.0 0.3 8.7e-06 26.0 0.1 2.1 2 0 0 2 2 2 1 Globin EXOSC1 PF10447.4 CDF89275.1 - 2.4e-32 110.7 0.3 5.3e-32 109.6 0.0 1.7 2 0 0 2 2 2 1 Exosome component EXOSC1/CSL4 S1 PF00575.18 CDF89275.1 - 0.039 14.0 0.3 4.9 7.3 0.0 2.9 3 0 0 3 3 3 0 S1 RNA binding domain CRAL_TRIO PF00650.15 CDF89276.1 - 1.3e-39 135.2 0.0 2.4e-39 134.3 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 CDF89276.1 - 8.9e-13 48.1 0.2 3e-12 46.4 0.2 2.0 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Elongin_A PF06881.6 CDF89277.1 - 7e-20 71.4 13.2 1.5e-16 60.7 0.9 2.5 1 1 1 2 2 2 2 RNA polymerase II transcription factor SIII (Elongin) subunit A Prefoldin_2 PF01920.15 CDF89277.1 - 0.025 14.3 6.1 2.5 7.9 3.8 2.2 2 0 0 2 2 2 0 Prefoldin subunit GST_C PF00043.20 CDF89278.1 - 8.6e-20 70.5 0.0 8.6e-20 70.5 0.0 1.7 2 0 0 2 2 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 CDF89278.1 - 6.8e-15 55.0 0.0 1.3e-14 54.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.1 CDF89278.1 - 2.1e-10 40.4 0.0 4e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.1 CDF89278.1 - 6.6e-10 39.0 0.0 1.2e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 CDF89278.1 - 0.0047 16.7 0.0 0.0093 15.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain AlkA_N PF06029.6 CDF89278.1 - 0.046 13.7 0.7 0.35 10.9 0.0 2.5 2 1 1 3 3 3 0 AlkA N-terminal domain Activator_LAG-3 PF11498.3 CDF89278.1 - 0.12 11.1 34.0 0.16 10.7 23.6 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 SprA-related PF12118.3 CDF89278.1 - 1.7 7.8 18.7 2.4 7.4 13.0 1.1 1 0 0 1 1 1 0 SprA-related family Suf PF05843.9 CDF89278.1 - 2.5 7.7 9.7 4.1 7.0 6.7 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) FimP PF09766.4 CDF89278.1 - 2.6 7.0 16.2 1.5 7.8 9.9 1.5 2 0 0 2 2 2 0 Fms-interacting protein DUF4557 PF15101.1 CDF89278.1 - 2.9 7.6 12.9 4.5 7.0 8.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4557) DOR PF14839.1 CDF89278.1 - 3.8 7.2 11.0 5.4 6.6 7.7 1.2 1 0 0 1 1 1 0 DOR family CDI PF02234.14 CDF89278.1 - 4.2 7.2 0.0 4.2 7.2 0.0 3.1 2 1 0 2 2 1 0 Cyclin-dependent kinase inhibitor DnaJ PF00226.26 CDF89279.1 - 6e-26 89.9 2.5 1.2e-25 89.0 0.1 2.8 2 0 0 2 2 2 1 DnaJ domain zf-C2H2_jaz PF12171.3 CDF89279.1 - 5.3e-07 29.5 8.4 5.8e-07 29.4 1.7 2.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 CDF89279.1 - 7.1e-07 29.2 5.9 0.0078 16.3 1.0 2.8 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.1 CDF89279.1 - 4.4e-05 23.2 4.1 0.0066 16.3 0.3 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.2 CDF89279.1 - 4.7e-05 23.4 8.5 4.8e-05 23.3 1.5 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.21 CDF89279.1 - 0.00013 22.0 6.9 0.15 12.4 0.6 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type AKAP95 PF04988.7 CDF89279.1 - 0.0088 15.8 0.1 0.0088 15.8 0.1 2.7 3 0 0 3 3 3 1 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_4 PF13894.1 CDF89279.1 - 0.025 14.8 3.9 0.29 11.5 0.3 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger SID PF11778.3 CDF89280.1 - 3.8e-49 166.1 1.5 3.8e-49 166.1 1.0 2.9 2 1 0 2 2 2 1 Septation initiation IncA PF04156.9 CDF89280.1 - 0.00013 21.5 126.1 0.34 10.4 12.3 6.6 2 2 4 6 6 6 6 IncA protein Reo_sigmaC PF04582.7 CDF89280.1 - 0.035 13.2 47.6 0.03 13.4 5.1 5.5 1 1 2 5 5 5 0 Reovirus sigma C capsid protein AAA_13 PF13166.1 CDF89280.1 - 1.5 7.1 107.0 0.0056 15.2 11.8 4.1 1 1 3 4 4 4 0 AAA domain G-patch PF01585.18 CDF89281.1 - 2.9e-11 42.9 4.0 2.9e-11 42.9 2.8 2.3 2 0 0 2 2 2 1 G-patch domain R3H PF01424.17 CDF89281.1 - 0.038 13.6 0.0 0.095 12.4 0.0 1.7 1 0 0 1 1 1 0 R3H domain Peptidase_C54 PF03416.14 CDF89282.1 - 5e-83 278.4 0.0 6.4e-83 278.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 Ssu72 PF04722.8 CDF89283.1 - 3.4e-86 287.5 0.0 3.9e-86 287.3 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein Amidohydro_1 PF01979.15 CDF89284.1 - 5.3e-52 177.5 0.0 6.3e-52 177.2 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.6 CDF89284.1 - 6e-06 25.7 0.1 8.3e-05 21.9 0.0 2.1 2 0 0 2 2 2 1 Amidohydrolase family Amidohydro_4 PF13147.1 CDF89284.1 - 0.001 19.1 0.1 0.097 12.6 0.0 2.3 2 0 0 2 2 2 1 Amidohydrolase Amidohydro_5 PF13594.1 CDF89284.1 - 0.018 14.8 0.0 0.045 13.5 0.0 1.7 1 0 0 1 1 1 0 Amidohydrolase POP1 PF06978.6 CDF89286.1 - 1.4e-65 220.4 6.0 2.9e-65 219.4 4.2 1.6 1 0 0 1 1 1 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.7 CDF89286.1 - 4.8e-30 103.2 0.8 1.1e-29 102.0 0.5 1.7 1 0 0 1 1 1 1 POPLD (NUC188) domain GCV_T_C PF08669.6 CDF89286.1 - 0.0052 16.7 0.0 0.013 15.4 0.0 1.7 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Adenylsucc_synt PF00709.16 CDF89287.1 - 8.5e-166 551.7 0.0 9.6e-166 551.6 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase DUF1033 PF06279.6 CDF89287.1 - 0.2 11.4 0.5 0.38 10.5 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1033) Glyco_transf_22 PF03901.12 CDF89288.1 - 4.7e-88 295.9 29.7 5.9e-88 295.6 20.6 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Hydrolase_6 PF13344.1 CDF89289.1 - 9.7e-30 102.4 0.0 2.4e-29 101.1 0.0 1.7 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 CDF89289.1 - 4.6e-13 48.6 0.0 7.9e-13 47.9 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 CDF89289.1 - 2.5e-10 41.1 0.0 3.9e-09 37.2 0.0 2.3 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 CDF89289.1 - 2.2e-05 24.7 0.1 0.006 16.8 0.1 2.6 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.9 CDF89289.1 - 0.15 11.3 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) MgsA_C PF12002.3 CDF89290.1 - 4.5e-52 176.1 0.1 8.9e-52 175.1 0.0 1.5 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA PF00004.24 CDF89290.1 - 6e-15 55.6 0.0 1e-14 54.8 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 CDF89290.1 - 9e-14 51.0 0.0 1.9e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 CDF89290.1 - 6.4e-08 32.5 0.0 1.2e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDF89290.1 - 1.3e-07 31.7 0.3 0.00013 22.0 0.0 2.5 1 1 1 2 2 2 2 AAA ATPase domain AAA_5 PF07728.9 CDF89290.1 - 4.7e-07 29.6 0.0 9.5e-07 28.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 CDF89290.1 - 3.9e-06 27.0 0.4 7.3e-05 22.9 0.3 2.5 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.21 CDF89290.1 - 5.1e-06 26.0 0.0 4.7e-05 22.9 0.0 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain Mg_chelatase PF01078.16 CDF89290.1 - 2.8e-05 23.3 0.2 0.071 12.2 0.0 2.2 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_2 PF07724.9 CDF89290.1 - 5.6e-05 23.1 0.0 0.00011 22.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.8 CDF89290.1 - 0.00018 20.4 0.0 0.00029 19.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.12 CDF89290.1 - 0.0015 17.9 0.0 0.0024 17.3 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.1 CDF89290.1 - 0.0046 17.2 0.0 0.012 15.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain Sigma54_activ_2 PF14532.1 CDF89290.1 - 0.006 16.6 0.0 0.016 15.2 0.0 1.7 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_10 PF12846.2 CDF89290.1 - 0.0062 16.0 0.3 0.34 10.2 0.0 2.3 1 1 1 2 2 2 1 AAA-like domain zf-C2HC_2 PF13913.1 CDF89290.1 - 0.0067 16.0 0.0 0.017 14.7 0.0 1.7 1 0 0 1 1 1 1 zinc-finger of a C2HC-type AAA_17 PF13207.1 CDF89290.1 - 0.0068 17.2 0.0 0.018 15.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.1 CDF89290.1 - 0.0069 15.9 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain ResIII PF04851.10 CDF89290.1 - 0.014 15.2 0.6 0.29 10.9 0.2 2.2 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.13 CDF89290.1 - 0.015 14.8 0.0 0.027 13.9 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.22 CDF89290.1 - 0.017 15.4 0.0 0.044 14.0 0.0 1.8 1 0 0 1 1 1 0 ABC transporter MMR_HSR1 PF01926.18 CDF89290.1 - 0.018 15.0 0.0 0.039 13.9 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_3 PF07726.6 CDF89290.1 - 0.021 14.4 0.0 0.038 13.5 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.8 CDF89290.1 - 0.021 13.5 0.0 0.065 11.9 0.0 1.6 1 1 1 2 2 2 0 TIP49 C-terminus AAA_30 PF13604.1 CDF89290.1 - 0.025 14.1 0.0 0.17 11.4 0.0 2.0 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 CDF89290.1 - 0.033 14.3 0.0 0.075 13.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Bac_DnaA PF00308.13 CDF89290.1 - 0.054 13.1 0.0 0.088 12.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial dnaA protein DUF258 PF03193.11 CDF89290.1 - 0.069 12.3 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 KTI12 PF08433.5 CDF89290.1 - 0.071 12.2 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_28 PF13521.1 CDF89290.1 - 0.088 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.5 CDF89290.1 - 0.095 11.9 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_33 PF13671.1 CDF89290.1 - 0.12 12.1 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Hpt PF01627.18 CDF89291.1 - 1.7e-12 47.1 0.2 3.6e-12 46.1 0.0 1.6 2 0 0 2 2 2 1 Hpt domain Metallophos PF00149.23 CDF89292.1 - 0.00013 21.3 0.6 0.0005 19.5 0.4 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Rap1-DNA-bind PF09197.5 CDF89293.1 - 1.8e-45 153.8 4.4 5e-41 139.5 0.1 3.1 2 1 0 2 2 2 2 Rap1, DNA-binding Rap1_C PF11626.3 CDF89293.1 - 1.1e-24 86.1 4.4 1.8e-24 85.4 0.0 3.5 4 0 0 4 4 4 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_2 PF08914.6 CDF89293.1 - 2.3e-08 33.7 0.1 0.00017 21.3 0.0 2.6 2 0 0 2 2 2 2 Rap1 Myb domain Myb_DNA-binding PF00249.26 CDF89293.1 - 9.2e-07 28.8 0.0 7e-06 26.0 0.0 2.6 3 0 0 3 3 3 1 Myb-like DNA-binding domain BRCT PF00533.21 CDF89293.1 - 0.001 19.1 0.0 0.0035 17.4 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DUF4557 PF15101.1 CDF89293.1 - 0.0039 17.0 4.9 0.0039 17.0 3.4 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4557) RabGAP-TBC PF00566.13 CDF89294.1 - 2.6e-34 118.5 18.1 4.6e-32 111.2 6.1 2.4 2 0 0 2 2 2 2 Rab-GTPase-TBC domain DUF3548 PF12068.3 CDF89294.1 - 1.7e-05 24.2 0.0 0.0092 15.2 0.0 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF3548) PAPA-1 PF04795.7 CDF89295.1 - 4.5e-15 56.1 4.9 4.5e-15 56.1 3.4 2.9 3 1 0 3 3 3 1 PAPA-1-like conserved region LIM_bind PF01803.11 CDF89296.1 - 7e-15 54.7 0.4 1.2e-14 54.0 0.3 1.3 1 0 0 1 1 1 1 LIM-domain binding protein GCN5L1 PF06320.8 CDF89296.1 - 0.0085 15.9 0.8 0.03 14.1 0.1 2.1 2 0 0 2 2 2 1 GCN5-like protein 1 (GCN5L1) OmpA PF00691.15 CDF89297.1 - 0.12 12.8 0.0 0.36 11.2 0.0 1.8 2 0 0 2 2 2 0 OmpA family Neugrin PF06413.6 CDF89298.1 - 2e-08 34.3 1.8 2e-08 34.3 1.2 1.5 2 0 0 2 2 2 1 Neugrin Sigma70_r4 PF04545.11 CDF89298.1 - 0.0037 16.5 0.1 0.0082 15.4 0.1 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_11 PF08279.7 CDF89298.1 - 0.033 13.8 0.0 0.076 12.6 0.0 1.6 1 0 0 1 1 1 0 HTH domain VID27 PF08553.5 CDF89299.1 - 1.6e-291 969.2 5.3 2e-291 968.9 3.6 1.0 1 0 0 1 1 1 1 VID27 cytoplasmic protein DUF2697 PF10906.3 CDF89300.1 - 1.5e-29 101.7 0.6 1.8e-29 101.5 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2697) Ost4 PF10215.4 CDF89301.1 - 6.6e-13 47.9 1.4 7.5e-13 47.7 1.0 1.0 1 0 0 1 1 1 1 Oligosaccaryltransferase FUSC_2 PF13515.1 CDF89302.1 - 3.1e-07 30.3 7.1 3.1e-07 30.3 4.9 2.7 2 1 0 2 2 2 1 Fusaric acid resistance protein-like DUF2421 PF10334.4 CDF89302.1 - 1.5e-06 28.0 0.5 2.9e-06 27.0 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2421) DUF2422 PF10337.4 CDF89302.1 - 0.00043 19.1 8.5 0.00054 18.8 1.6 3.1 2 1 0 2 2 2 1 Protein of unknown function (DUF2422) Y_phosphatase PF00102.22 CDF89303.1 - 5.5e-57 192.7 1.7 8.9e-56 188.8 1.1 2.4 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.15 CDF89303.1 - 5.1e-05 22.8 0.0 9.3e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 CDF89303.1 - 0.00044 20.3 0.1 0.0066 16.5 0.0 2.2 1 1 1 2 2 2 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.1 CDF89303.1 - 0.0059 16.8 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family KH_1 PF00013.24 CDF89304.1 - 1.5e-06 27.7 0.5 5.5e-06 25.9 0.0 2.2 3 0 0 3 3 3 1 KH domain KH_3 PF13014.1 CDF89304.1 - 2.4e-05 23.8 0.1 4.7e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 KH domain KH_2 PF07650.12 CDF89304.1 - 0.0059 16.1 0.2 0.02 14.4 0.1 1.9 1 0 0 1 1 1 1 KH domain Tn7_Tnp_TnsA_N PF08722.6 CDF89304.1 - 0.083 12.8 0.1 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 TnsA endonuclease N terminal HSP70 PF00012.15 CDF89305.1 - 1.8e-236 785.7 8.0 2e-236 785.6 5.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 CDF89305.1 - 1.8e-17 62.9 0.4 6.2e-16 57.8 0.1 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Hom_end_hint PF05203.11 CDF89306.1 - 2.9e-47 161.1 0.0 3.5e-47 160.9 0.0 1.0 1 0 0 1 1 1 1 Hom_end-associated Hint Hom_end PF05204.9 CDF89306.1 - 7.6e-47 157.8 0.0 3.2e-37 126.8 0.0 2.7 2 0 0 2 2 2 2 Homing endonuclease LAGLIDADG_3 PF14528.1 CDF89306.1 - 3e-08 33.8 0.0 5.5e-05 23.3 0.0 3.1 2 1 0 2 2 2 2 LAGLIDADG-like domain DUF1794 PF08768.6 CDF89306.1 - 0.07 12.9 0.3 0.17 11.7 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1794) Rick_17kDa_Anti PF05433.10 CDF89307.1 - 1.1e-05 24.9 12.3 1.1e-05 24.9 8.6 3.7 4 1 0 4 4 4 1 Glycine zipper 2TM domain zf-LITAF-like PF10601.4 CDF89308.1 - 0.17 11.7 1.3 0.18 11.6 0.1 1.6 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain E6 PF00518.12 CDF89309.1 - 0.01 16.1 1.6 0.017 15.4 1.1 1.3 1 0 0 1 1 1 0 Early Protein (E6) RIO1 PF01163.17 CDF89310.1 - 4.7e-41 140.2 0.1 8.7e-41 139.3 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.6 CDF89310.1 - 1.3e-31 108.4 0.0 3.2e-31 107.2 0.0 1.7 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.18 CDF89310.1 - 1.2e-07 31.7 0.1 0.0017 18.1 0.0 3.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 CDF89310.1 - 0.0029 16.6 0.1 0.036 13.1 0.1 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Rtt106 PF08512.7 CDF89311.1 - 3.8e-30 103.7 0.6 8.4e-30 102.6 0.4 1.6 1 0 0 1 1 1 1 Histone chaperone Rttp106-like CENP-T PF15511.1 CDF89311.1 - 0.15 11.2 24.1 0.21 10.7 16.7 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T Cwf_Cwc_15 PF04889.7 CDF89311.1 - 8.2 6.0 25.9 15 5.2 17.9 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein ArfGap PF01412.13 CDF89312.1 - 6.9e-34 116.1 0.1 2.6e-33 114.2 0.0 1.9 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf adh_short_C2 PF13561.1 CDF89313.1 - 1.8e-28 99.9 0.0 2.2e-28 99.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CDF89313.1 - 1.3e-23 83.7 0.9 2e-23 83.1 0.6 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CDF89313.1 - 4.1e-12 46.1 0.1 6.4e-12 45.4 0.1 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.10 CDF89313.1 - 0.0019 17.1 0.0 0.0036 16.2 0.0 1.4 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein SMK-1 PF04802.10 CDF89314.1 - 3.1e-63 212.7 9.9 5.1e-63 212.1 4.8 2.3 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 WH1 PF00568.18 CDF89314.1 - 0.056 13.1 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 WH1 domain YjeF_N PF03853.10 CDF89315.1 - 6.6e-36 123.4 0.0 7.9e-36 123.2 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus Septin PF00735.13 CDF89316.1 - 1.4e-74 250.6 0.8 4.1e-67 226.1 0.6 2.2 2 0 0 2 2 2 2 Septin AAA_22 PF13401.1 CDF89316.1 - 0.00017 21.7 0.0 0.00089 19.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 CDF89316.1 - 0.0002 21.2 0.0 0.00057 19.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.13 CDF89316.1 - 0.00069 19.1 0.0 0.0018 17.7 0.0 1.7 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_17 PF13207.1 CDF89316.1 - 0.0017 19.2 0.8 0.0057 17.4 0.1 2.5 2 1 0 2 2 1 1 AAA domain AAA_10 PF12846.2 CDF89316.1 - 0.0032 16.9 0.2 0.022 14.1 0.0 2.3 2 2 0 2 2 2 1 AAA-like domain AAA PF00004.24 CDF89316.1 - 0.0032 17.6 0.2 0.0082 16.3 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 CDF89316.1 - 0.0055 17.0 0.3 0.027 14.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.1 CDF89316.1 - 0.013 15.1 0.1 0.044 13.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain Synaptobrevin PF00957.16 CDF89316.1 - 0.024 14.2 1.4 0.088 12.4 1.0 2.0 1 0 0 1 1 1 0 Synaptobrevin AAA_16 PF13191.1 CDF89316.1 - 0.024 14.6 1.9 0.06 13.3 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain Mg_chelatase PF01078.16 CDF89316.1 - 0.025 13.7 0.0 0.065 12.3 0.0 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF258 PF03193.11 CDF89316.1 - 0.027 13.6 0.0 0.069 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Dynamin_N PF00350.18 CDF89316.1 - 0.027 14.2 0.3 0.17 11.6 0.0 2.4 3 0 0 3 3 3 0 Dynamin family PduV-EutP PF10662.4 CDF89316.1 - 0.03 13.8 0.0 0.069 12.6 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.17 CDF89316.1 - 0.032 14.4 0.0 0.089 12.9 0.0 1.8 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.12 CDF89316.1 - 0.056 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_5 PF07728.9 CDF89316.1 - 0.063 13.0 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.21 CDF89316.1 - 0.069 12.6 0.0 0.19 11.2 0.0 1.7 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_29 PF13555.1 CDF89316.1 - 0.13 11.7 0.0 0.32 10.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain OmpH PF03938.9 CDF89316.1 - 0.44 10.4 7.5 0.7 9.8 4.2 2.0 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) RRM_1 PF00076.17 CDF89317.1 - 8.1e-18 63.8 0.0 1.1e-15 56.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF89317.1 - 9.4e-09 35.1 0.0 2.2e-07 30.7 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) POT1 PF02765.12 CDF89320.1 - 4.7e-12 46.0 0.1 7.8e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 Chitin_synth_1 PF01644.12 CDF89322.1 - 4.3e-73 244.4 0.4 6.3e-73 243.9 0.3 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.6 CDF89322.1 - 1.5e-27 95.0 0.0 3.3e-27 94.0 0.0 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.10 CDF89322.1 - 6.9e-19 67.6 9.9 1.6e-14 53.2 3.0 2.5 2 1 1 3 3 3 2 Chitin synthase Glyco_trans_2_3 PF13632.1 CDF89322.1 - 7.3e-12 45.3 3.5 2.4e-11 43.6 2.4 1.9 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.1 CDF89322.1 - 6.7e-09 35.8 0.0 1.9e-08 34.4 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.21 CDF89322.1 - 0.043 13.4 0.0 2.5 7.7 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferase family 2 Tyr_Deacylase PF02580.11 CDF89323.1 - 3.8e-46 156.6 0.2 4.2e-46 156.5 0.1 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase GATase_4 PF13230.1 CDF89324.1 - 6.7e-18 64.3 0.0 1.4e-16 60.0 0.0 2.1 1 1 0 1 1 1 1 Glutamine amidotransferases class-II GATase_6 PF13522.1 CDF89324.1 - 2.1e-11 43.8 0.0 4.8e-11 42.7 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_2 PF00310.16 CDF89324.1 - 2e-09 36.6 0.0 2.2e-07 29.9 0.0 2.2 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_7 PF13537.1 CDF89324.1 - 0.0099 15.6 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain Arm PF00514.18 CDF89326.1 - 8.9e-87 282.3 15.0 1.3e-13 50.1 0.1 8.9 10 0 0 10 10 10 8 Armadillo/beta-catenin-like repeat IBB PF01749.15 CDF89326.1 - 8.6e-25 86.7 4.5 1.7e-24 85.8 3.2 1.5 1 0 0 1 1 1 1 Importin beta binding domain HEAT_2 PF13646.1 CDF89326.1 - 2.6e-23 82.1 0.2 1.6e-06 28.3 0.0 5.5 1 1 4 5 5 5 5 HEAT repeats HEAT_EZ PF13513.1 CDF89326.1 - 3e-18 65.7 2.1 8.8e-06 26.0 0.0 6.5 5 2 4 9 9 9 4 HEAT-like repeat HEAT PF02985.17 CDF89326.1 - 3.1e-12 45.4 0.1 0.013 15.4 0.0 6.9 7 0 0 7 7 7 4 HEAT repeat Arm_2 PF04826.8 CDF89326.1 - 9.8e-08 31.4 0.3 0.37 9.8 0.0 4.9 3 2 2 5 5 5 3 Armadillo-like V-ATPase_H_C PF11698.3 CDF89326.1 - 1.7e-05 24.7 0.1 0.11 12.3 0.0 4.4 3 1 2 5 5 5 1 V-ATPase subunit H Proteasom_PSMB PF10508.4 CDF89326.1 - 5.3e-05 21.6 0.4 0.0027 16.0 0.1 2.7 2 1 1 3 3 3 1 Proteasome non-ATPase 26S subunit Adaptin_N PF01602.15 CDF89326.1 - 0.0001 20.7 0.1 0.0011 17.3 0.0 2.4 1 1 0 1 1 1 1 Adaptin N terminal region Tim17 PF02466.14 CDF89328.1 - 5e-48 162.3 7.1 6.1e-48 162.0 4.9 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DLH PF01738.13 CDF89328.1 - 0.019 14.2 0.0 0.043 13.0 0.0 1.6 1 0 0 1 1 1 0 Dienelactone hydrolase family Hum_adeno_E3A PF05393.6 CDF89328.1 - 0.15 11.7 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein JAB PF01398.16 CDF89330.1 - 1.2e-31 108.8 0.1 3.3e-31 107.3 0.1 1.8 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.1 CDF89330.1 - 2.3e-08 33.5 0.0 1.3e-07 31.0 0.0 2.1 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.8 CDF89330.1 - 0.0019 17.6 0.0 0.011 15.2 0.0 2.1 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0172) RVT_connect PF06815.8 CDF89330.1 - 0.099 12.5 0.0 0.29 11.0 0.0 1.8 1 0 0 1 1 1 0 Reverse transcriptase connection domain ELFV_dehydrog PF00208.16 CDF89331.1 - 8.8e-60 202.3 0.0 1.4e-59 201.6 0.0 1.4 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.7 CDF89331.1 - 4.4e-19 67.5 0.1 3.2e-13 48.1 0.0 2.4 2 1 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.13 CDF89331.1 - 0.067 12.7 0.0 0.27 10.8 0.0 2.0 2 0 0 2 2 2 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Ribosomal_L11_N PF03946.9 CDF89333.1 - 3e-27 93.8 0.4 5e-27 93.1 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 CDF89333.1 - 3.2e-26 91.2 0.9 5e-26 90.6 0.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Pkinase PF00069.20 CDF89334.1 - 1.2e-63 214.7 0.0 1.8e-63 214.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF89334.1 - 8e-23 80.8 0.0 1.4e-22 80.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RRM_1 PF00076.17 CDF89335.1 - 1.8e-06 27.4 0.0 3.5e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF89335.1 - 2.1e-05 24.3 0.0 3.7e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) HSP90 PF00183.13 CDF89335.1 - 0.0042 15.5 1.2 0.0049 15.3 0.9 1.2 1 0 0 1 1 1 1 Hsp90 protein TAF4 PF05236.9 CDF89335.1 - 0.14 11.3 9.9 0.29 10.3 2.8 2.1 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family adh_short PF00106.20 CDF89336.1 - 1.4e-07 31.5 0.0 2.5e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CDF89336.1 - 1.5e-06 28.0 0.0 2.7e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 KR domain DUF3139 PF11337.3 CDF89336.1 - 0.13 12.5 0.3 0.3 11.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) Ras PF00071.17 CDF89337.1 - 4.1e-48 162.8 0.0 6.1e-48 162.2 0.0 1.3 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDF89337.1 - 8.1e-14 52.1 0.0 4.7e-13 49.6 0.0 2.2 1 1 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDF89337.1 - 8.6e-05 21.8 0.0 0.00017 20.9 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 CDF89337.1 - 0.083 12.8 0.0 0.24 11.3 0.0 1.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 CDF89337.1 - 0.09 11.8 1.9 0.13 11.4 0.0 2.2 2 1 0 2 2 2 0 Gtr1/RagA G protein conserved region OPA3 PF07047.7 CDF89337.1 - 0.099 12.4 4.4 0.16 11.7 3.1 1.3 1 0 0 1 1 1 0 Optic atrophy 3 protein (OPA3) GTP_EFTU PF00009.22 CDF89337.1 - 0.16 11.3 0.5 2 7.8 0.0 2.7 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain Ribosomal_S3_C PF00189.15 CDF89338.1 - 1.5e-15 57.1 0.1 2.4e-15 56.5 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.12 CDF89338.1 - 4.2e-12 45.4 0.1 1.1e-11 44.0 0.1 1.7 2 0 0 2 2 2 1 KH domain SHR3_chaperone PF08229.6 CDF89339.1 - 4.2e-71 237.9 0.0 4.2e-71 237.9 0.0 2.0 2 0 0 2 2 2 1 ER membrane protein SH3 Ycf1 PF05758.7 CDF89339.1 - 0.026 12.2 3.8 0.029 12.1 2.6 1.0 1 0 0 1 1 1 0 Ycf1 IncA PF04156.9 CDF89339.1 - 0.033 13.7 0.3 0.11 12.0 0.1 1.9 2 0 0 2 2 2 0 IncA protein DUF4094 PF13334.1 CDF89339.1 - 0.035 14.4 3.1 1.8 8.9 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4094) Bromo_MP PF01573.11 CDF89339.1 - 0.045 12.7 6.1 0.057 12.3 4.2 1.1 1 0 0 1 1 1 0 Bromovirus movement protein MLANA PF14991.1 CDF89339.1 - 0.075 13.0 0.0 12 5.9 0.0 2.4 2 0 0 2 2 2 0 Protein melan-A Nop53 PF07767.6 CDF89339.1 - 1.7 7.5 24.4 2.2 7.1 16.9 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Ribosomal_L22 PF00237.14 CDF89340.1 - 1.8e-19 69.6 0.0 2.8e-19 68.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e TAA-Trp-ring PF15401.1 CDF89340.1 - 0.14 12.3 0.3 0.28 11.4 0.2 1.3 1 0 0 1 1 1 0 Tryptophan-ring motif of head of Trimeric autotransporter adhesin ATP-synt_ab PF00006.20 CDF89343.1 - 6.4e-119 395.1 0.0 1.9e-118 393.5 0.0 1.8 1 1 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain Hom_end_hint PF05203.11 CDF89343.1 - 4.5e-74 248.8 0.1 7.5e-74 248.0 0.1 1.4 1 0 0 1 1 1 1 Hom_end-associated Hint Hom_end PF05204.9 CDF89343.1 - 9e-64 212.3 0.0 2.4e-40 136.8 0.0 2.5 2 0 0 2 2 2 2 Homing endonuclease ATP-synt_ab_C PF00306.22 CDF89343.1 - 1e-18 67.8 0.0 2.6e-18 66.5 0.0 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 CDF89343.1 - 8e-15 54.8 3.0 2.1e-14 53.4 2.1 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain LAGLIDADG_3 PF14528.1 CDF89343.1 - 1e-08 35.3 0.1 0.00022 21.3 0.0 2.6 2 0 0 2 2 2 2 LAGLIDADG-like domain Hint PF01079.15 CDF89343.1 - 0.0002 20.6 0.0 0.00064 18.9 0.0 1.8 1 0 0 1 1 1 1 Hint module Hint_2 PF13403.1 CDF89343.1 - 0.0013 18.6 0.1 0.004 17.1 0.1 1.9 2 0 0 2 2 2 1 Hint domain AAA_14 PF13173.1 CDF89343.1 - 0.12 12.2 0.0 0.46 10.3 0.0 2.0 1 0 0 1 1 1 0 AAA domain Mit_KHE1 PF10173.4 CDF89344.1 - 6.4e-56 189.1 0.7 6.4e-56 189.1 0.5 1.3 2 0 0 2 2 2 1 Mitochondrial K+-H+ exchange-related MARVEL PF01284.18 CDF89345.1 - 0.00043 20.1 3.3 0.00066 19.5 2.3 1.2 1 0 0 1 1 1 1 Membrane-associating domain DctQ PF04290.7 CDF89345.1 - 0.1 12.3 3.4 0.53 10.0 2.4 2.0 1 1 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component DUF3671 PF12420.3 CDF89345.1 - 0.27 11.2 4.1 6.2 6.8 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function HMGL-like PF00682.14 CDF89346.1 - 1.2e-74 250.9 0.2 1.8e-74 250.3 0.1 1.3 1 0 0 1 1 1 1 HMGL-like ADP_PFK_GK PF04587.10 CDF89346.1 - 0.0017 16.6 0.0 0.0025 16.0 0.0 1.2 1 0 0 1 1 1 1 ADP-specific Phosphofructokinase/Glucokinase conserved region IATP PF04568.7 CDF89347.1 - 1.1e-18 67.0 0.7 1.1e-18 67.0 0.5 1.0 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP Rabaptin PF03528.10 CDF89347.1 - 0.0012 18.7 1.5 0.0012 18.7 1.0 1.1 1 0 0 1 1 1 1 Rabaptin Ribosomal_60s PF00428.14 CDF89348.1 - 4e-23 81.6 14.0 4.9e-23 81.3 9.7 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein DDE_Tnp_ISL3 PF01610.12 CDF89349.1 - 0.037 13.6 2.1 0.05 13.1 1.4 1.2 1 0 0 1 1 1 0 Transposase Pol_alpha_B_N PF08418.5 CDF89349.1 - 0.33 10.4 13.9 2.7 7.4 7.9 2.2 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal Na_Ca_ex PF01699.19 CDF89351.1 - 8.3e-51 171.2 27.0 8.7e-26 90.1 2.8 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein AAA PF00004.24 CDF89352.1 - 1.7e-98 325.9 0.0 4.9e-48 162.6 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 CDF89352.1 - 4.4e-19 68.2 2.1 6.6e-19 67.6 0.3 2.3 3 0 0 3 3 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.9 CDF89352.1 - 3.6e-14 53.0 0.1 2.8e-07 30.6 0.0 3.4 3 1 0 3 3 3 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 CDF89352.1 - 1.8e-13 50.0 0.0 1.4e-05 24.2 0.0 3.0 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_5 PF07728.9 CDF89352.1 - 7.9e-13 48.3 1.5 2e-06 27.5 0.0 4.0 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 CDF89352.1 - 9.2e-12 45.3 0.0 0.0004 20.4 0.0 3.4 2 2 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.1 CDF89352.1 - 1.4e-11 44.4 0.0 5.7e-06 26.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 CDF89352.1 - 3.3e-11 44.0 0.5 0.0011 19.7 0.0 3.9 4 0 0 4 4 2 2 AAA domain CDC48_2 PF02933.12 CDF89352.1 - 1e-10 41.0 0.0 2.7e-10 39.7 0.0 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_22 PF13401.1 CDF89352.1 - 2e-10 40.9 3.6 0.0012 18.9 0.1 4.4 3 2 0 4 4 3 2 AAA domain TIP49 PF06068.8 CDF89352.1 - 2.7e-09 36.2 0.0 0.0012 17.5 0.0 2.5 2 0 0 2 2 2 2 TIP49 C-terminus AAA_14 PF13173.1 CDF89352.1 - 2.6e-08 33.8 0.0 0.004 17.0 0.0 3.0 3 0 0 3 3 2 2 AAA domain IstB_IS21 PF01695.12 CDF89352.1 - 8.1e-08 31.8 0.1 0.0072 15.7 0.0 3.0 3 0 0 3 3 2 2 IstB-like ATP binding protein AAA_19 PF13245.1 CDF89352.1 - 1.8e-07 30.8 1.1 0.02 14.6 0.0 2.9 2 0 0 2 2 2 2 Part of AAA domain AAA_25 PF13481.1 CDF89352.1 - 2.1e-07 30.5 6.1 0.019 14.3 0.1 4.3 2 2 2 4 4 4 2 AAA domain RNA_helicase PF00910.17 CDF89352.1 - 2.3e-07 30.9 0.0 0.0092 16.1 0.0 2.9 3 0 0 3 3 2 2 RNA helicase Mg_chelatase PF01078.16 CDF89352.1 - 2.6e-07 30.0 0.4 0.022 13.9 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 CDF89352.1 - 5e-07 29.0 0.1 0.011 14.9 0.0 3.0 3 0 0 3 3 3 2 Zeta toxin KaiC PF06745.8 CDF89352.1 - 3.4e-06 26.3 3.7 0.44 9.6 0.0 4.1 3 1 1 4 4 4 2 KaiC AAA_24 PF13479.1 CDF89352.1 - 4.7e-06 26.3 0.0 0.11 12.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain ResIII PF04851.10 CDF89352.1 - 8.2e-06 25.7 0.0 0.0092 15.8 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Sigma54_activat PF00158.21 CDF89352.1 - 1.3e-05 24.7 0.1 0.13 11.6 0.0 3.6 3 1 0 3 3 2 2 Sigma-54 interaction domain AAA_18 PF13238.1 CDF89352.1 - 1.3e-05 25.5 0.0 0.19 12.0 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.1 CDF89352.1 - 1.3e-05 25.2 0.0 0.24 11.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain Parvo_NS1 PF01057.12 CDF89352.1 - 2e-05 23.6 0.0 0.12 11.1 0.0 2.7 3 0 0 3 3 3 2 Parvovirus non-structural protein NS1 PhoH PF02562.11 CDF89352.1 - 2.3e-05 23.7 0.5 0.11 11.7 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein ABC_tran PF00005.22 CDF89352.1 - 2.5e-05 24.6 0.0 0.087 13.1 0.0 3.8 3 1 0 3 3 2 1 ABC transporter Sigma54_activ_2 PF14532.1 CDF89352.1 - 3.3e-05 23.9 0.0 0.17 11.9 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain Vps4_C PF09336.5 CDF89352.1 - 3.7e-05 23.5 0.1 0.0012 18.7 0.0 2.7 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_11 PF13086.1 CDF89352.1 - 3.8e-05 23.3 0.0 0.27 10.7 0.0 2.6 2 1 0 2 2 2 2 AAA domain DUF815 PF05673.8 CDF89352.1 - 6.4e-05 21.9 0.0 0.14 11.0 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF815) AAA_3 PF07726.6 CDF89352.1 - 0.00011 21.7 0.0 0.66 9.5 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Bac_DnaA PF00308.13 CDF89352.1 - 0.00012 21.8 0.0 0.35 10.4 0.0 3.4 4 0 0 4 4 3 1 Bacterial dnaA protein NACHT PF05729.7 CDF89352.1 - 0.0002 21.0 0.1 1.6 8.3 0.0 3.5 3 0 0 3 3 3 1 NACHT domain DUF2075 PF09848.4 CDF89352.1 - 0.00048 19.2 0.0 0.67 8.8 0.0 2.5 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) Arch_ATPase PF01637.13 CDF89352.1 - 0.00052 19.7 2.5 0.51 9.9 0.0 4.0 3 2 2 5 5 3 1 Archaeal ATPase AAA_30 PF13604.1 CDF89352.1 - 0.00059 19.4 0.0 1.7 8.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain NB-ARC PF00931.17 CDF89352.1 - 0.0049 15.7 0.1 1.9 7.3 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain KAP_NTPase PF07693.9 CDF89352.1 - 0.013 14.5 0.2 1.6 7.6 0.0 3.0 2 2 1 3 3 3 0 KAP family P-loop domain IPT PF01745.11 CDF89352.1 - 0.015 14.5 0.1 1.8 7.6 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase Zot PF05707.7 CDF89352.1 - 0.021 14.3 0.5 5.4 6.4 0.1 3.7 3 1 0 3 3 2 0 Zonular occludens toxin (Zot) NTPase_1 PF03266.10 CDF89352.1 - 0.037 13.7 3.2 3.3 7.3 0.0 4.1 5 0 0 5 5 3 0 NTPase SKI PF01202.17 CDF89352.1 - 0.055 13.3 0.0 4.6 7.0 0.0 2.6 2 0 0 2 2 2 0 Shikimate kinase UPF0079 PF02367.12 CDF89352.1 - 0.059 13.0 0.1 7 6.2 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 T2SE PF00437.15 CDF89352.1 - 0.073 11.9 0.0 3 6.6 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein UFD1 PF03152.9 CDF89352.1 - 0.11 11.5 0.0 0.35 10.0 0.0 1.7 1 1 1 2 2 2 0 Ubiquitin fusion degradation protein UFD1 Viral_helicase1 PF01443.13 CDF89352.1 - 0.15 11.5 0.0 16 4.9 0.0 3.1 4 0 0 4 4 4 0 Viral (Superfamily 1) RNA helicase DEAD PF00270.24 CDF89352.1 - 0.17 11.3 0.4 26 4.2 0.0 3.4 3 1 0 4 4 3 0 DEAD/DEAH box helicase Serglycin PF04360.7 CDF89352.1 - 0.26 11.0 3.5 1.6 8.4 1.3 2.4 2 0 0 2 2 2 0 Serglycin HIT PF01230.18 CDF89353.1 - 1.7e-25 89.4 0.2 2.6e-25 88.7 0.0 1.4 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.3 CDF89353.1 - 2.7e-09 37.2 0.4 4.7e-09 36.4 0.2 1.4 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.10 CDF89353.1 - 0.015 14.9 0.7 0.036 13.7 0.5 1.7 1 1 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 Strep_his_triad PF04270.8 CDF89353.1 - 0.29 10.8 2.6 1.2 8.8 0.1 2.2 2 0 0 2 2 2 0 Streptococcal histidine triad protein Aldo_ket_red PF00248.16 CDF89354.1 - 7.3e-48 162.8 0.1 9.1e-48 162.4 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family UPF0029 PF01205.14 CDF89355.1 - 8.9e-33 112.2 0.3 2.7e-32 110.7 0.2 1.7 1 1 0 1 1 1 1 Uncharacterized protein family UPF0029 VitD-bind_III PF09164.5 CDF89355.1 - 0.026 14.1 0.0 0.045 13.3 0.0 1.4 1 0 0 1 1 1 0 Vitamin D binding protein, domain III zf-CCHC PF00098.18 CDF89358.1 - 7.2e-12 44.6 36.1 0.00012 21.7 1.4 5.1 5 0 0 5 5 5 3 Zinc knuckle zf-CCHC_3 PF13917.1 CDF89358.1 - 0.23 11.2 0.2 0.23 11.2 0.1 3.6 3 0 0 3 3 3 0 Zinc knuckle zf-CCHC_2 PF13696.1 CDF89358.1 - 4 7.0 18.7 0.49 9.9 0.2 4.2 3 1 1 4 4 4 0 Zinc knuckle zf-CCHC_4 PF14392.1 CDF89358.1 - 4.3 7.0 34.6 0.22 11.1 0.4 5.4 4 1 1 5 5 5 0 Zinc knuckle tRNA-synt_2b PF00587.20 CDF89359.1 - 9.2e-43 145.8 0.3 1.7e-42 144.9 0.2 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 CDF89359.1 - 1.8e-21 75.8 0.3 4.4e-21 74.6 0.2 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.9 CDF89359.1 - 1.5e-13 50.3 0.0 2.8e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.16 CDF89359.1 - 6e-11 42.0 0.0 1.3e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 TGS domain DUF1689 PF07954.6 CDF89360.1 - 6.5e-45 152.6 0.2 9.3e-45 152.1 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1689) Coatomer_E PF04733.9 CDF89361.1 - 1.1e-08 34.6 8.2 3.7e-08 32.8 5.7 1.9 1 1 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.1 CDF89361.1 - 0.00046 20.4 5.7 0.7 10.2 0.3 3.8 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.1 CDF89361.1 - 0.016 15.8 0.1 75 4.3 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Lebercilin PF15619.1 CDF89361.1 - 0.041 13.3 2.2 0.25 10.7 0.8 2.3 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease TPR_4 PF07721.9 CDF89361.1 - 0.39 11.2 4.5 45 4.8 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat GET2 PF08690.5 CDF89362.1 - 3.4e-65 220.2 0.0 4.3e-65 219.9 0.0 1.1 1 0 0 1 1 1 1 GET complex subunit GET2 HXXSHH PF07586.6 CDF89362.1 - 0.053 12.4 0.0 4.8 6.0 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1552) DHO_dh PF01180.16 CDF89363.1 - 8.8e-97 323.6 0.0 1e-96 323.3 0.0 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.13 CDF89363.1 - 0.00032 19.6 0.0 0.067 12.0 0.0 2.4 2 1 0 2 2 2 2 FMN-dependent dehydrogenase DUF1694 PF07997.6 CDF89363.1 - 0.14 12.1 0.1 0.31 10.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1694) BING4CT PF08149.6 CDF89364.1 - 5.7e-37 125.0 0.0 2.3e-35 119.9 0.0 3.2 4 0 0 4 4 4 1 BING4CT (NUC141) domain WD40 PF00400.27 CDF89364.1 - 2e-07 30.6 0.0 3.4e-05 23.5 0.0 4.2 5 0 0 5 5 5 1 WD domain, G-beta repeat 2-Hacid_dh_C PF02826.14 CDF89365.1 - 3.6e-51 172.8 0.0 5.7e-51 172.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 CDF89365.1 - 7.1e-37 125.8 0.0 9.3e-37 125.4 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 CDF89365.1 - 0.0005 19.9 0.1 0.001 18.9 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ACT PF01842.20 CDF89365.1 - 0.00081 18.8 0.0 0.0027 17.1 0.0 1.9 1 0 0 1 1 1 1 ACT domain AdoHcyase_NAD PF00670.16 CDF89365.1 - 0.017 14.9 0.0 0.038 13.8 0.0 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain XdhC_C PF13478.1 CDF89365.1 - 0.13 12.5 0.0 0.45 10.8 0.0 1.8 2 0 0 2 2 2 0 XdhC Rossmann domain UDPG_MGDP_dh_N PF03721.9 CDF89365.1 - 0.13 11.5 0.6 7.2 5.9 0.1 2.3 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain APH PF01636.18 CDF89367.1 - 2.1e-09 37.4 0.0 1.7e-08 34.4 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family HORMA PF02301.13 CDF89369.1 - 2e-51 174.4 1.4 2e-51 174.4 1.0 2.1 2 0 0 2 2 2 1 HORMA domain PHD_2 PF13831.1 CDF89369.1 - 0.08 12.2 8.2 0.22 10.8 5.7 1.7 1 0 0 1 1 1 0 PHD-finger Peptidase_M24 PF00557.19 CDF89370.1 - 2.2e-52 177.6 0.1 3.5e-52 177.0 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 CDF89370.1 - 1.3e-32 111.9 0.0 3.4e-32 110.6 0.0 1.7 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain PPR_2 PF13041.1 CDF89372.1 - 2.2e-14 53.1 0.2 4.5e-09 36.1 0.1 3.3 3 1 1 4 4 4 2 PPR repeat family DUF465 PF04325.8 CDF89372.1 - 0.0034 17.0 0.2 0.011 15.4 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF465) PPR PF01535.15 CDF89372.1 - 0.092 12.7 0.0 7.7 6.7 0.0 3.9 4 0 0 4 4 4 0 PPR repeat MAM33 PF02330.11 CDF89373.1 - 1.4e-50 171.8 7.4 1.6e-50 171.6 5.1 1.0 1 0 0 1 1 1 1 Mitochondrial glycoprotein Cons_hypoth95 PF03602.10 CDF89373.1 - 0.073 12.4 0.1 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 MipZ PF09140.6 CDF89373.1 - 0.11 11.5 0.0 0.28 10.2 0.0 1.7 2 0 0 2 2 2 0 ATPase MipZ Y_phosphatase PF00102.22 CDF89374.1 - 3e-52 177.2 0.4 5.3e-52 176.4 0.3 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.15 CDF89374.1 - 8e-09 35.8 0.0 3e-08 34.0 0.0 2.0 2 0 0 2 2 2 1 Rhodanese-like domain DSPc PF00782.15 CDF89374.1 - 0.013 15.1 0.0 0.04 13.5 0.0 1.8 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.1 CDF89374.1 - 0.053 13.7 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Tyrosine phosphatase family Yos1 PF08571.5 CDF89375.1 - 1.1e-24 86.2 4.8 3.6e-19 68.6 0.1 2.0 1 1 1 2 2 2 2 Yos1-like Ribosomal_S24e PF01282.14 CDF89376.1 - 6.6e-35 118.7 0.0 1.1e-34 118.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S24e Aldedh PF00171.17 CDF89377.1 - 3.2e-179 596.0 0.0 3.6e-179 595.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF202 PF02656.10 CDF89378.1 - 5.3e-13 48.9 3.7 5.3e-13 48.9 2.6 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Tctex-1 PF03645.8 CDF89379.1 - 1.8e-09 37.3 0.0 2.1e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 Tctex-1 family Sec6 PF06046.8 CDF89380.1 - 1.9e-162 541.3 14.8 2.4e-162 540.9 10.3 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec6 LCCL PF03815.14 CDF89381.1 - 5.8e-09 35.8 0.0 9.6e-09 35.1 0.0 1.3 1 0 0 1 1 1 1 LCCL domain Ribonuc_red_lgC PF02867.10 CDF89382.1 - 2.5e-215 716.1 0.0 3.2e-215 715.7 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 CDF89382.1 - 5.3e-23 80.6 0.0 1.4e-22 79.2 0.0 1.8 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 CDF89382.1 - 2.9e-16 59.6 0.1 1.4e-15 57.4 0.0 2.3 2 0 0 2 2 2 1 ATP cone domain NRDD PF13597.1 CDF89382.1 - 0.0055 14.8 0.0 0.0082 14.2 0.0 1.2 1 0 0 1 1 1 1 Anaerobic ribonucleoside-triphosphate reductase Fis1_TPR_C PF14853.1 CDF89383.1 - 3e-26 91.0 0.4 4.3e-26 90.5 0.3 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.1 CDF89383.1 - 1.4e-15 56.2 0.0 2.3e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_19 PF14559.1 CDF89383.1 - 0.0024 18.1 0.0 0.0051 17.1 0.0 1.6 1 1 0 1 1 1 1 Tetratricopeptide repeat SKG6 PF08693.5 CDF89383.1 - 0.02 14.1 0.9 0.037 13.3 0.6 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Titin_Z PF09042.6 CDF89383.1 - 0.38 10.3 4.5 0.68 9.5 3.1 1.4 1 0 0 1 1 1 0 Titin Z UCR_Fe-S_N PF10399.4 CDF89383.1 - 9.5 5.4 9.2 1.9e+02 1.3 0.0 2.5 3 0 0 3 3 3 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Methyltransf_31 PF13847.1 CDF89384.1 - 2.6e-23 82.2 0.0 3.6e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDF89384.1 - 4e-17 62.8 0.0 6.1e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDF89384.1 - 6.2e-08 33.0 0.1 1e-07 32.3 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CDF89384.1 - 7.7e-08 32.3 0.0 1.2e-07 31.7 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDF89384.1 - 8.9e-07 29.3 0.0 1.3e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 CDF89384.1 - 8.4e-06 25.5 0.0 1.1e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CDF89384.1 - 1.4e-05 24.5 0.0 2.4e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 CDF89384.1 - 2.6e-05 24.4 0.0 4.3e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDF89384.1 - 8.3e-05 22.3 0.0 0.00015 21.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain TehB PF03848.9 CDF89384.1 - 0.00043 19.4 0.0 0.00062 18.9 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_4 PF02390.12 CDF89384.1 - 0.00068 18.7 0.0 0.001 18.1 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase CMAS PF02353.15 CDF89384.1 - 0.0024 16.9 0.0 0.0029 16.7 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase AdoMet_MTase PF07757.8 CDF89384.1 - 0.0076 16.3 0.0 0.016 15.3 0.0 1.6 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase MetW PF07021.7 CDF89384.1 - 0.07 12.4 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Ran_BP1 PF00638.13 CDF89385.1 - 1.2e-34 119.0 0.3 3.1e-34 117.6 0.2 1.8 1 0 0 1 1 1 1 RanBP1 domain Reo_sigmaC PF04582.7 CDF89385.1 - 0.084 12.0 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Toxin_63 PF15541.1 CDF89385.1 - 0.11 12.5 2.2 2.2 8.2 0.0 2.9 3 0 0 3 3 3 0 Putative toxin 63 P16-Arc PF04699.9 CDF89386.1 - 4.1e-53 179.4 0.0 4.5e-53 179.3 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Methyltransf_26 PF13659.1 CDF89386.1 - 0.15 12.1 0.1 4.9 7.2 0.0 2.1 1 1 1 2 2 2 0 Methyltransferase domain DUF619 PF04768.8 CDF89387.1 - 3.7e-53 179.4 0.4 8.2e-53 178.3 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF619) Semialdhyde_dh PF01118.19 CDF89387.1 - 3.4e-29 101.6 0.0 7.1e-29 100.5 0.0 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain AA_kinase PF00696.23 CDF89387.1 - 3.3e-19 69.3 0.1 5.9e-19 68.5 0.0 1.5 1 0 0 1 1 1 1 Amino acid kinase family Semialdhyde_dhC PF02774.13 CDF89387.1 - 7.4e-09 35.7 0.0 1.9e-08 34.3 0.0 1.8 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain U1snRNP70_N PF12220.3 CDF89388.1 - 1.6e-20 73.2 1.1 2.7e-20 72.4 0.7 1.4 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.17 CDF89388.1 - 6.4e-17 60.9 0.0 1.1e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF89388.1 - 1.1e-12 47.7 0.0 1.9e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF89388.1 - 1.8e-06 27.6 0.0 3.4e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_4 PF14570.1 CDF89389.1 - 5e-20 70.8 13.6 8.9e-20 70.0 9.4 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_5 PF13893.1 CDF89389.1 - 2.3e-06 27.3 0.1 0.017 14.9 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Baculo_IE-1 PF05290.6 CDF89389.1 - 1.1e-05 25.1 3.3 1.9e-05 24.3 2.3 1.3 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-C3HC4_3 PF13920.1 CDF89389.1 - 2.6e-05 23.8 7.1 5.1e-05 22.8 4.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.17 CDF89389.1 - 9.5e-05 21.9 0.0 0.014 15.0 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Rtf2 PF04641.7 CDF89389.1 - 0.00032 20.0 1.8 0.00032 20.0 1.2 2.0 2 0 0 2 2 2 1 Rtf2 RING-finger zf-RING_2 PF13639.1 CDF89389.1 - 0.0004 20.1 8.8 0.00076 19.2 6.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 CDF89389.1 - 0.0018 17.9 11.2 0.0034 16.9 7.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SET_assoc PF11767.3 CDF89389.1 - 0.014 14.6 0.0 0.034 13.4 0.0 1.6 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated zf-UDP PF14569.1 CDF89389.1 - 0.033 13.9 3.8 0.076 12.7 2.6 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-C3HC4_2 PF13923.1 CDF89389.1 - 0.056 13.4 10.7 0.11 12.5 7.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RRM_6 PF14259.1 CDF89389.1 - 0.058 13.3 0.0 1.4 8.9 0.0 2.6 2 0 0 2 2 2 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) zf-RING_5 PF14634.1 CDF89389.1 - 0.32 10.7 10.0 0.62 9.8 7.0 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.1 CDF89389.1 - 1.1 8.8 9.1 1.3 8.6 2.9 2.6 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.1 CDF89389.1 - 8.2 6.4 12.0 52 3.8 8.4 2.3 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING DUF2578 PF10843.3 CDF89390.1 - 7.9e-58 195.3 6.9 9.1e-58 195.1 4.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2578) ICL PF00463.16 CDF89391.1 - 1.4e-265 881.4 1.6 1.6e-265 881.3 1.1 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.1 CDF89391.1 - 4.8e-11 42.3 0.1 9.5e-11 41.3 0.0 1.5 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Vhr1 PF04001.8 CDF89392.1 - 3.5e-48 161.4 0.5 6.1e-48 160.6 0.3 1.4 1 0 0 1 1 1 1 Transcription factor Vhr1 SAP PF02037.22 CDF89394.1 - 7e-10 38.1 0.1 1.3e-09 37.2 0.1 1.5 1 0 0 1 1 1 1 SAP domain Lin-8 PF03353.10 CDF89394.1 - 0.18 11.0 4.8 0.23 10.7 3.3 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Menin PF05053.8 CDF89394.1 - 0.36 8.9 3.7 0.43 8.6 2.6 1.1 1 0 0 1 1 1 0 Menin DUF4554 PF15091.1 CDF89394.1 - 0.58 8.8 4.1 0.78 8.4 2.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Vfa1 PF08432.5 CDF89394.1 - 2.6 8.0 8.9 1.8 8.5 5.3 1.4 1 1 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 ketoacyl-synt PF00109.21 CDF89396.1 - 3.5e-54 183.9 0.2 4.7e-54 183.5 0.2 1.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 CDF89396.1 - 2.8e-31 107.8 0.1 5.6e-31 106.8 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.18 CDF89396.1 - 0.016 14.1 0.3 0.032 13.2 0.2 1.4 1 0 0 1 1 1 0 Thiolase, N-terminal domain ACP_syn_III PF08545.5 CDF89396.1 - 0.2 11.3 2.6 1.1 8.9 0.0 2.9 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Transp_cyt_pur PF02133.10 CDF89397.1 - 1.5e-81 274.2 40.7 1.7e-81 274.0 28.2 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Cyclin PF08613.6 CDF89398.1 - 6.5e-44 149.9 5.7 2.5e-42 144.8 3.9 2.6 1 1 0 1 1 1 1 Cyclin ALMT PF11744.3 CDF89398.1 - 8.7 4.8 8.5 5 5.6 4.5 1.6 1 1 0 1 1 1 0 Aluminium activated malate transporter rRNA_processing PF08524.6 CDF89399.1 - 0.0056 16.4 4.9 0.0069 16.1 3.4 1.2 1 0 0 1 1 1 1 rRNA processing Sugar_tr PF00083.19 CDF89399.1 - 0.03 12.9 0.1 0.035 12.6 0.0 1.0 1 0 0 1 1 1 0 Sugar (and other) transporter Nop25 PF09805.4 CDF89399.1 - 0.59 10.2 9.3 0.75 9.8 6.5 1.1 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Ribonuc_L-PSP PF01042.16 CDF89400.1 - 8.1e-43 145.0 0.4 9.4e-43 144.8 0.3 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Ribosomal_L22 PF00237.14 CDF89401.1 - 1.9e-32 111.2 0.3 1.9e-32 111.2 0.2 1.5 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e CASP_C PF08172.7 CDF89402.1 - 9.6e-73 244.2 2.1 9.6e-73 244.2 1.4 4.1 1 1 3 4 4 4 1 CASP C terminal ADIP PF11559.3 CDF89402.1 - 0.005 16.7 11.3 0.01 15.7 2.4 6.7 4 1 1 6 6 6 2 Afadin- and alpha -actinin-Binding NPV_P10 PF05531.7 CDF89402.1 - 0.02 15.1 0.1 0.02 15.1 0.1 5.4 4 2 2 6 6 6 0 Nucleopolyhedrovirus P10 protein DUF4140 PF13600.1 CDF89402.1 - 3.1 8.2 41.5 3.2 8.2 1.1 7.0 5 2 2 7 7 7 0 N-terminal domain of unknown function (DUF4140) Sulfate_transp PF00916.15 CDF89403.1 - 2.3e-55 187.5 7.5 2.3e-55 187.5 5.2 1.9 3 0 0 3 3 3 1 Sulfate transporter family STAS PF01740.16 CDF89403.1 - 1.1e-15 57.0 1.0 2.3e-15 56.0 0.7 1.6 1 0 0 1 1 1 1 STAS domain cNMP_binding PF00027.24 CDF89403.1 - 4.1e-06 26.5 0.0 9.2e-06 25.3 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Lyase_1 PF00206.15 CDF89404.1 - 1.4e-116 389.1 0.0 1.7e-116 388.7 0.0 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.4 CDF89404.1 - 1.2e-24 86.1 0.0 3.5e-24 84.6 0.0 1.9 1 0 0 1 1 1 1 Fumarase C C-terminus Peptidase_S8 PF00082.17 CDF89405.1 - 3.2e-54 183.9 6.1 4.7e-54 183.4 4.3 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 CDF89405.1 - 6.3e-10 39.4 0.1 1.4e-09 38.4 0.0 1.6 1 0 0 1 1 1 1 Peptidase inhibitor I9 Fcf1 PF04900.7 CDF89406.1 - 5.8e-33 113.0 0.4 5.8e-33 113.0 0.3 1.8 2 0 0 2 2 2 1 Fcf1 Kinesin PF00225.18 CDF89407.1 - 9.6e-97 323.6 13.7 8.9e-64 215.3 6.1 3.4 3 1 0 3 3 3 2 Kinesin motor domain Cob_adeno_trans PF01923.13 CDF89407.1 - 0.86 9.3 9.7 0.85 9.3 0.7 3.9 3 1 1 4 4 4 0 Cobalamin adenosyltransferase NPR2 PF06218.6 CDF89408.1 - 3.9e-167 556.3 8.6 3.9e-167 556.3 5.9 1.9 2 0 0 2 2 2 2 Nitrogen permease regulator 2 DNA_ligase_A_M PF01068.16 CDF89409.1 - 4.2e-46 156.8 0.0 1.6e-45 155.0 0.0 1.9 2 0 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 CDF89409.1 - 1.5e-14 54.1 0.0 2.5e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 DNA ligase N terminus BRCT PF00533.21 CDF89409.1 - 4.7e-12 45.8 3.1 4.5e-08 33.1 0.1 3.1 2 1 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain DNA_ligase_A_C PF04679.10 CDF89409.1 - 0.0001 22.6 0.0 0.00022 21.5 0.0 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region NUFIP1 PF10453.4 CDF89409.1 - 1.4 8.4 7.0 0.28 10.7 1.1 2.3 2 0 0 2 2 2 0 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) DUF367 PF04034.8 CDF89410.1 - 1.7e-51 173.1 0.0 2.4e-51 172.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF367) RLI PF04068.10 CDF89410.1 - 8.3e-16 57.2 0.3 1.5e-15 56.4 0.2 1.5 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI CDC45 PF02724.9 CDF89410.1 - 0.0051 14.9 5.7 0.0049 14.9 3.1 1.5 2 0 0 2 2 2 1 CDC45-like protein DUF2407_C PF13373.1 CDF89410.1 - 3.8 7.4 5.3 8.2 6.3 3.7 1.5 1 0 0 1 1 1 0 DUF2407 C-terminal domain VPS9 PF02204.13 CDF89411.1 - 9.4e-12 44.8 0.6 1.4e-10 41.1 0.0 3.0 3 0 0 3 3 3 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.1 CDF89411.1 - 1.7e-10 40.8 0.1 7.5e-06 26.0 0.0 4.6 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 CDF89411.1 - 1.2e-07 31.9 0.5 0.00051 20.3 0.3 3.6 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CDF89411.1 - 0.00038 20.8 0.1 0.033 14.6 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.25 CDF89411.1 - 0.00052 19.6 0.6 0.057 13.2 0.0 4.1 5 0 0 5 5 5 1 Ankyrin repeat Ank_3 PF13606.1 CDF89411.1 - 0.0044 17.1 1.1 11 6.5 0.0 4.8 4 1 0 4 4 4 1 Ankyrin repeat DUF3113 PF11310.3 CDF89411.1 - 0.087 12.5 1.6 0.85 9.3 0.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3113) TPR_11 PF13414.1 CDF89412.1 - 1.7e-23 82.0 10.9 1.3e-17 63.1 1.7 3.3 2 1 0 3 3 3 2 TPR repeat TPR_1 PF00515.23 CDF89412.1 - 1.3e-18 65.7 9.9 2.3e-07 30.1 0.1 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 CDF89412.1 - 1.7e-17 61.8 6.6 1.8e-05 24.2 0.2 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.1 CDF89412.1 - 2.1e-09 36.8 0.8 0.0064 16.5 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 CDF89412.1 - 3.1e-09 37.2 9.6 4.3e-06 27.2 2.1 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 CDF89412.1 - 9.8e-09 35.0 5.8 3.3e-08 33.3 0.9 2.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 CDF89412.1 - 2.3e-07 30.8 0.4 0.081 13.6 0.0 3.7 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 CDF89412.1 - 2.4e-06 26.9 2.6 0.025 14.3 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 CDF89412.1 - 3.2e-06 26.5 12.9 0.0022 17.6 0.5 3.5 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 CDF89412.1 - 2.1e-05 24.7 6.0 0.02 15.2 0.3 3.3 1 1 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.1 CDF89412.1 - 0.0032 17.3 1.0 4.8 7.2 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 CDF89412.1 - 0.0053 17.1 7.0 0.12 12.9 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 CDF89412.1 - 0.02 14.7 1.2 2.5 8.0 0.0 3.4 3 1 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Apc3 PF12895.2 CDF89412.1 - 0.021 14.9 1.8 0.06 13.4 1.2 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 CDF89412.1 - 0.038 13.8 0.8 0.11 12.4 0.0 2.2 2 1 0 2 2 2 0 Tetratricopeptide repeat BTAD PF03704.12 CDF89412.1 - 0.039 14.2 0.1 0.039 14.2 0.0 2.0 2 1 1 3 3 2 0 Bacterial transcriptional activator domain DUF2366 PF10171.4 CDF89412.1 - 0.072 12.5 0.5 0.38 10.2 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2366) MIT PF04212.13 CDF89412.1 - 0.23 11.3 14.1 0.4 10.5 0.2 4.2 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain Alg6_Alg8 PF03155.10 CDF89413.1 - 5.9e-161 536.4 29.9 7.2e-161 536.1 20.8 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Pirin PF02678.11 CDF89414.1 - 6.9e-28 96.6 0.1 1.5e-27 95.6 0.0 1.6 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.8 CDF89414.1 - 1.3e-18 66.9 0.0 2.4e-17 62.9 0.0 2.2 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.6 CDF89414.1 - 0.00012 21.5 0.9 0.00033 20.0 0.6 1.7 1 0 0 1 1 1 1 Cupin domain Ras PF00071.17 CDF89415.1 - 1.2e-57 193.7 0.3 1.5e-57 193.5 0.2 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDF89415.1 - 1.1e-18 67.8 0.0 2.3e-18 66.8 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDF89415.1 - 2.7e-15 56.0 0.1 3.1e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 CDF89415.1 - 3.2e-08 33.2 0.4 8e-07 28.6 0.3 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 CDF89415.1 - 3.4e-08 32.9 0.1 3.9e-08 32.7 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.18 CDF89415.1 - 8e-06 25.7 0.0 1.1e-05 25.3 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 CDF89415.1 - 1e-05 24.8 0.1 1.4e-05 24.4 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.1 CDF89415.1 - 5e-05 23.4 0.0 0.00013 22.1 0.0 1.7 1 1 1 2 2 2 1 AAA domain ATP_bind_1 PF03029.12 CDF89415.1 - 9.6e-05 22.0 0.7 0.0023 17.5 0.1 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_16 PF13191.1 CDF89415.1 - 0.00049 20.1 0.1 0.011 15.7 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.1 CDF89415.1 - 0.0025 17.4 0.3 0.0069 15.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 CDF89415.1 - 0.0043 16.2 0.1 0.0095 15.1 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF258 NTPase_1 PF03266.10 CDF89415.1 - 0.0049 16.6 0.1 0.015 15.0 0.0 1.8 2 0 0 2 2 2 1 NTPase PduV-EutP PF10662.4 CDF89415.1 - 0.0078 15.7 0.5 0.092 12.2 0.3 2.3 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation MobB PF03205.9 CDF89415.1 - 0.008 15.8 0.2 0.017 14.8 0.1 1.9 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.14 CDF89415.1 - 0.012 15.0 0.1 0.03 13.7 0.0 1.7 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Arch_ATPase PF01637.13 CDF89415.1 - 0.013 15.2 0.2 0.024 14.3 0.1 1.8 1 1 0 1 1 1 0 Archaeal ATPase NACHT PF05729.7 CDF89415.1 - 0.015 14.9 0.0 0.031 13.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_35 PF14516.1 CDF89415.1 - 0.058 12.0 0.1 0.25 9.9 0.0 1.8 2 0 0 2 2 2 0 AAA-like domain NB-ARC PF00931.17 CDF89415.1 - 0.058 12.2 0.0 0.1 11.4 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain Bac_DnaA PF00308.13 CDF89415.1 - 0.071 12.7 0.1 0.1 12.2 0.0 1.4 1 1 0 1 1 1 0 Bacterial dnaA protein AAA_10 PF12846.2 CDF89415.1 - 0.083 12.3 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain Septin PF00735.13 CDF89415.1 - 0.098 11.6 0.1 0.26 10.2 0.0 1.7 2 0 0 2 2 2 0 Septin DNA_pol_A_exo1 PF01612.15 CDF89416.1 - 2e-48 164.1 0.4 6.8e-48 162.4 0.3 2.0 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.7 CDF89416.1 - 1.9e-24 85.7 5.1 3.6e-23 81.6 0.7 3.0 2 0 0 2 2 2 2 PMC2NT (NUC016) domain HRDC PF00570.18 CDF89416.1 - 3.6e-10 39.4 0.0 2.6e-09 36.6 0.0 2.6 3 0 0 3 3 3 1 HRDC domain Cyclin PF08613.6 CDF89417.1 - 1.9e-33 116.0 1.0 4e-33 114.9 0.7 1.6 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 CDF89417.1 - 0.00058 19.4 0.1 0.0012 18.4 0.1 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain HlyIII PF03006.15 CDF89418.1 - 6.9e-55 185.8 22.2 8.4e-55 185.5 15.4 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF4231 PF14015.1 CDF89418.1 - 0.18 11.8 4.4 0.24 11.3 0.2 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF4231) DUF981 PF06168.6 CDF89418.1 - 0.34 10.6 10.4 0.012 15.3 3.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF981) Cation_ATPase_C PF00689.16 CDF89418.1 - 0.46 9.9 10.4 2.1 7.8 7.0 2.2 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus zf-DHHC PF01529.15 CDF89419.1 - 1.5e-30 105.8 15.6 1.5e-30 105.8 10.8 2.0 1 1 1 2 2 2 1 DHHC palmitoyltransferase PAH PF02671.16 CDF89420.1 - 2.5e-47 158.2 5.7 1e-18 66.6 0.4 3.8 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.7 CDF89420.1 - 1.5e-43 146.6 2.2 2.5e-43 145.9 0.3 2.4 2 0 0 2 2 2 1 Sin3 family co-repressor AAA_23 PF13476.1 CDF89420.1 - 0.00017 22.0 0.9 0.00017 22.0 0.6 6.2 3 2 0 4 4 4 1 AAA domain RNA_pol_L_2 PF13656.1 CDF89421.1 - 5.5e-25 86.5 0.0 7e-25 86.2 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 CDF89421.1 - 7.4e-11 41.0 0.0 1e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain TMEM154 PF15102.1 CDF89422.1 - 0.068 12.8 0.0 0.18 11.4 0.0 1.7 1 0 0 1 1 1 0 TMEM154 protein family Vpu PF00558.14 CDF89422.1 - 0.07 12.6 0.3 0.15 11.5 0.2 1.6 1 1 0 1 1 1 0 Vpu protein DUF2076 PF09849.4 CDF89423.1 - 0.00034 20.7 19.4 0.00034 20.7 13.4 1.5 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.8 CDF89423.1 - 0.00089 19.1 5.1 0.0014 18.4 3.5 1.4 1 0 0 1 1 1 1 CHCH domain Gly-zipper_OmpA PF13436.1 CDF89423.1 - 0.011 15.4 5.1 0.011 15.4 3.6 1.9 2 0 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain RAB3GAP2_N PF14655.1 CDF89423.1 - 0.045 12.7 0.1 0.054 12.4 0.0 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Nucleoporin_FG PF13634.1 CDF89423.1 - 0.05 13.8 15.9 0.07 13.3 11.0 1.2 1 0 0 1 1 1 0 Nucleoporin FG repeat region COX6B PF02297.12 CDF89423.1 - 0.24 11.4 4.3 0.38 10.7 3.0 1.3 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb PAT1 PF09770.4 CDF89423.1 - 5 5.2 11.8 5.4 5.1 8.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SAP PF02037.22 CDF89424.1 - 2.3e-08 33.3 1.1 4.2e-08 32.4 0.8 1.5 1 0 0 1 1 1 1 SAP domain Polyketide_cyc PF03364.15 CDF89425.1 - 1.7e-17 63.6 0.0 2.1e-17 63.3 0.0 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.4 CDF89425.1 - 0.0017 18.5 0.0 0.0023 18.1 0.0 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DUF2404 PF10296.4 CDF89426.1 - 0.016 15.3 0.0 0.049 13.7 0.0 1.9 1 1 0 1 1 1 0 Putative integral membrane protein conserved region (DUF2404) PX PF00787.19 CDF89427.1 - 6.4e-22 77.4 0.2 1.5e-21 76.3 0.1 1.6 1 0 0 1 1 1 1 PX domain RTC PF01137.16 CDF89428.1 - 3.3e-57 192.8 0.0 4.1e-57 192.5 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.8 CDF89428.1 - 8.8e-30 102.7 0.0 1.6e-29 101.9 0.0 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain TAF4 PF05236.9 CDF89429.1 - 4.2e-68 229.4 0.4 4.2e-68 229.4 0.3 2.1 2 0 0 2 2 2 1 Transcription initiation factor TFIID component TAF4 family TFIID_30kDa PF03540.8 CDF89429.1 - 0.0087 15.8 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit GCV_T_C PF08669.6 CDF89429.1 - 0.019 14.9 0.1 0.041 13.9 0.1 1.5 1 0 0 1 1 1 0 Glycine cleavage T-protein C-terminal barrel domain PLA2_B PF01735.13 CDF89430.1 - 4.1e-165 549.6 3.9 4.9e-165 549.4 2.7 1.0 1 0 0 1 1 1 1 Lysophospholipase catalytic domain PLA2_B PF01735.13 CDF89431.1 - 2e-216 718.9 1.7 2.4e-216 718.6 1.2 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain Herpes_capsid PF06112.6 CDF89431.1 - 3 7.8 13.8 7 6.6 9.5 1.6 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Histone PF00125.19 CDF89432.1 - 4.3e-22 78.0 0.1 5.5e-22 77.6 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.18 CDF89432.1 - 0.002 18.1 0.0 0.0027 17.7 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone zf-RING_2 PF13639.1 CDF89433.1 - 5.5e-10 38.9 10.8 3.6e-09 36.2 7.5 2.2 1 1 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 CDF89433.1 - 8.4e-08 32.2 3.7 8.4e-08 32.2 2.6 1.7 2 0 0 2 2 2 1 RING-H2 zinc finger zf-C3HC4_3 PF13920.1 CDF89433.1 - 8.1e-06 25.4 8.1 5.9e-05 22.6 5.6 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDF89433.1 - 1.4e-05 25.0 2.5 1.4e-05 25.0 1.7 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDF89433.1 - 1.5e-05 24.5 7.0 3.7e-05 23.2 4.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDF89433.1 - 2.3e-05 24.0 5.5 5e-05 22.9 3.8 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 CDF89433.1 - 0.0073 15.9 1.4 0.0073 15.9 1.0 2.8 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 CDF89433.1 - 0.012 15.4 6.2 0.19 11.6 1.1 2.6 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-Apc11 PF12861.2 CDF89433.1 - 0.021 14.6 2.6 0.027 14.3 0.5 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 CDF89433.1 - 2.9 7.5 7.3 0.1 12.2 0.6 1.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain RNA_pol_I_TF PF04090.7 CDF89434.1 - 2.4e-69 232.5 0.1 3.7e-69 231.9 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase I specific initiation factor Sof1 PF04158.9 CDF89434.1 - 0.026 14.5 1.2 0.066 13.2 0.8 1.6 1 0 0 1 1 1 0 Sof1-like domain Cgr1 PF03879.9 CDF89435.1 - 1.8e-36 124.6 35.7 2.1e-36 124.3 24.7 1.0 1 0 0 1 1 1 1 Cgr1 family DUF1525 PF07511.6 CDF89435.1 - 4.2 7.3 7.2 7.5 6.5 4.8 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1525) DUF2048 PF09752.4 CDF89435.1 - 5 5.9 6.8 6.2 5.5 4.7 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2048) PPR_2 PF13041.1 CDF89436.1 - 2.2e-16 59.5 2.7 1.6e-09 37.6 0.2 4.1 2 1 1 3 3 3 2 PPR repeat family PPR_3 PF13812.1 CDF89436.1 - 1.3e-09 37.5 1.2 0.076 13.3 0.0 5.9 6 0 0 6 6 6 2 Pentatricopeptide repeat domain PPR PF01535.15 CDF89436.1 - 1.4e-08 34.0 0.1 0.00023 20.9 0.1 3.5 2 0 0 2 2 2 2 PPR repeat PPR_1 PF12854.2 CDF89436.1 - 5e-06 25.8 0.0 0.032 13.7 0.0 2.7 2 0 0 2 2 2 2 PPR repeat DUF2838 PF10998.3 CDF89437.1 - 6.5e-42 141.9 14.8 6.5e-42 141.9 10.3 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF2838) CX PF01705.14 CDF89437.1 - 0.0052 16.7 0.0 0.016 15.1 0.0 1.8 1 0 0 1 1 1 1 CX module Ribosomal_L7Ae PF01248.21 CDF89438.1 - 1.8e-24 85.0 0.0 2e-24 84.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ribosomal_L24e PF01246.15 CDF89439.1 - 3.7e-33 113.1 0.4 3.7e-33 113.1 0.3 2.1 2 1 0 2 2 2 1 Ribosomal protein L24e RR_TM4-6 PF06459.7 CDF89439.1 - 3.1 7.6 8.1 3.5 7.4 5.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1279 PF06916.8 CDF89440.1 - 5.1e-27 94.0 0.0 7.5e-27 93.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) zf-ZPR1 PF03367.8 CDF89440.1 - 0.056 12.5 0.2 0.08 12.0 0.2 1.2 1 0 0 1 1 1 0 ZPR1 zinc-finger domain Uricase PF01014.13 CDF89441.1 - 8.5e-70 233.2 0.2 1.3e-35 122.5 0.2 2.0 2 0 0 2 2 2 2 Uricase TBPIP PF07106.8 CDF89442.1 - 2.6e-40 137.7 4.1 3.2e-40 137.4 2.8 1.1 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) UPF0172 PF03665.8 CDF89442.1 - 0.097 12.1 0.2 0.13 11.6 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) zf-H2C2_2 PF13465.1 CDF89443.1 - 4.2e-12 45.7 14.1 4e-08 33.1 1.8 3.4 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.21 CDF89443.1 - 2e-08 34.0 15.4 7.6e-05 22.8 1.4 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CDF89443.1 - 2.6e-05 24.2 14.1 0.004 17.3 0.8 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger Rad50_zn_hook PF04423.9 CDF89443.1 - 0.0094 15.3 0.0 0.019 14.4 0.0 1.5 1 0 0 1 1 1 1 Rad50 zinc hook motif zf-C2H2_6 PF13912.1 CDF89443.1 - 0.011 15.5 7.0 0.38 10.7 0.5 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger PAT1 PF09770.4 CDF89443.1 - 0.071 11.3 12.2 0.088 11.0 8.5 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Corona_nucleoca PF00937.13 CDF89443.1 - 0.097 11.6 8.8 0.29 10.0 6.1 1.8 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Herpes_DNAp_acc PF04929.7 CDF89443.1 - 2.5 6.9 6.8 0.1 11.5 0.3 1.9 2 0 0 2 2 2 0 Herpes DNA replication accessory factor FAM176 PF14851.1 CDF89443.1 - 6.8 6.3 7.0 23 4.6 2.1 2.9 3 0 0 3 3 3 0 FAM176 family Ecl1 PF12855.2 CDF89444.1 - 4e-16 58.0 0.2 7e-16 57.2 0.1 1.4 1 0 0 1 1 1 1 Life-span regulatory factor zf-MYND PF01753.13 CDF89444.1 - 0.11 12.3 0.3 0.19 11.6 0.2 1.4 1 0 0 1 1 1 0 MYND finger SNARE PF05739.14 CDF89445.1 - 3.6e-05 23.3 4.7 3.6e-05 23.3 3.2 3.4 3 0 0 3 3 3 1 SNARE domain V-SNARE_C PF12352.3 CDF89445.1 - 0.04 14.0 0.6 0.04 14.0 0.4 2.4 3 0 0 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus NUC153 PF08159.7 CDF89446.1 - 1.9e-10 40.0 3.4 4e-10 39.1 2.4 1.6 1 0 0 1 1 1 1 NUC153 domain Isochorismatase PF00857.15 CDF89449.1 - 1.8e-27 96.3 0.0 2.3e-27 96.0 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family Gly_transf_sug PF04488.10 CDF89450.1 - 9.7e-13 48.4 0.0 2.9e-12 46.8 0.0 1.8 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 CDF89450.1 - 0.0093 14.4 0.0 0.039 12.4 0.0 2.0 3 0 0 3 3 3 1 TcdA/TcdB catalytic glycosyltransferase domain Ras PF00071.17 CDF89451.1 - 3.9e-51 172.6 0.0 5.2e-51 172.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDF89451.1 - 2e-17 63.7 0.0 3.9e-17 62.8 0.0 1.5 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDF89451.1 - 3.1e-08 33.0 0.1 4.1e-08 32.6 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 CDF89451.1 - 4.4e-07 29.5 0.0 8.1e-07 28.6 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CDF89451.1 - 0.011 15.7 1.0 0.035 14.0 0.0 2.1 2 1 0 2 2 2 0 50S ribosome-binding GTPase G-alpha PF00503.15 CDF89451.1 - 0.13 10.9 3.1 4 6.0 0.0 3.0 2 1 0 3 3 3 0 G-protein alpha subunit tRNA_bind PF01588.15 CDF89452.1 - 5.4e-18 64.6 0.1 1.1e-17 63.6 0.0 1.5 2 0 0 2 2 2 1 Putative tRNA binding domain PITH PF06201.8 CDF89453.1 - 2.5e-38 131.2 0.0 3.7e-38 130.6 0.0 1.2 1 0 0 1 1 1 1 PITH domain ALAD PF00490.16 CDF89454.1 - 2.8e-113 378.1 0.0 3.3e-113 377.8 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase PALP PF00291.20 CDF89455.1 - 1.3e-56 192.1 0.0 1.7e-56 191.7 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.23 CDF89455.1 - 1.2e-13 50.5 0.0 1.3e-09 37.6 0.0 2.6 2 0 0 2 2 2 2 CBS domain ComZ PF10815.3 CDF89456.1 - 0.00035 20.2 0.2 0.00077 19.1 0.1 1.6 1 0 0 1 1 1 1 ComZ AHH PF14412.1 CDF89456.1 - 0.12 12.3 0.1 4.6 7.2 0.0 2.1 1 1 1 2 2 2 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH TFIIS_M PF07500.9 CDF89457.1 - 5.9e-30 103.6 1.6 5.9e-30 103.6 1.1 1.8 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.13 CDF89457.1 - 1.5e-17 62.9 6.3 2.9e-17 62.0 4.4 1.5 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.6 CDF89457.1 - 3.1e-15 55.4 1.3 6.8e-15 54.3 0.9 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Phyto_Pns9_10 PF05878.6 CDF89457.1 - 0.14 11.1 3.1 0.15 11.0 1.8 1.3 1 1 0 1 1 1 0 Phytoreovirus nonstructural protein Pns9/Pns10 Ribosomal_S27 PF01599.14 CDF89457.1 - 0.54 10.1 3.7 2.3 8.1 0.2 2.5 2 0 0 2 2 2 0 Ribosomal protein S27a Zn_Tnp_IS1595 PF12760.2 CDF89457.1 - 1.3 8.9 5.4 4.7 7.0 3.9 1.9 1 1 0 1 1 1 0 Transposase zinc-ribbon domain RRM_1 PF00076.17 CDF89458.1 - 4.2e-21 74.3 0.0 6.6e-21 73.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF89458.1 - 4.1e-13 49.0 0.0 7.3e-13 48.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF89458.1 - 9.7e-11 41.3 0.0 1.5e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.1 CDF89458.1 - 2.1e-07 30.1 0.1 4.1e-07 29.1 0.1 1.4 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal CSTF2_hinge PF14327.1 CDF89458.1 - 0.00015 21.8 0.6 0.0003 20.8 0.0 1.8 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 PEMT PF04191.8 CDF89460.1 - 9e-55 183.2 21.0 5.5e-33 113.2 1.1 3.2 4 0 0 4 4 4 2 Phospholipid methyltransferase ICMT PF04140.9 CDF89460.1 - 0.038 14.1 2.6 1.8 8.7 0.2 3.2 2 1 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family RNase_PH PF01138.16 CDF89461.1 - 3e-16 59.9 0.1 4.6e-16 59.3 0.1 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Arrestin_N PF00339.24 CDF89462.1 - 1.4e-17 63.8 0.6 2.4e-16 59.9 0.0 2.6 2 1 1 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.17 CDF89462.1 - 5.9e-06 26.4 4.6 1.1e-05 25.4 0.1 2.9 1 1 2 3 3 3 1 Arrestin (or S-antigen), C-terminal domain DUF2120 PF09893.4 CDF89462.1 - 0.073 13.0 0.1 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) RRM_1 PF00076.17 CDF89463.1 - 3.2e-44 148.4 0.0 8.1e-21 73.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF89463.1 - 2.8e-30 104.0 0.0 5.3e-15 55.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF89463.1 - 6.4e-22 77.1 0.0 5.3e-11 42.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CDF89463.1 - 0.0078 15.9 0.0 0.53 10.0 0.0 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Herpes_BLRF2 PF05812.7 CDF89465.1 - 0.0073 16.1 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Herpesvirus BLRF2 protein DUF2046 PF09755.4 CDF89465.1 - 0.031 13.1 0.6 0.039 12.8 0.4 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) HALZ PF02183.13 CDF89465.1 - 0.073 12.7 1.0 0.15 11.8 0.7 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper Shugoshin_N PF07558.6 CDF89465.1 - 0.088 12.5 0.8 0.16 11.7 0.5 1.4 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region FAD_binding_8 PF08022.7 CDF89466.1 - 3.6e-24 84.6 0.0 8.4e-24 83.4 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.14 CDF89466.1 - 4.2e-20 72.0 8.5 4.2e-20 72.0 5.9 2.7 3 0 0 3 3 3 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.7 CDF89466.1 - 1.1e-14 54.5 0.0 2.3e-14 53.5 0.0 1.6 1 0 0 1 1 1 1 Ferric reductase NAD binding domain MFS_1 PF07690.11 CDF89467.1 - 3.1e-16 59.0 33.2 3.7e-15 55.4 23.9 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 CDF89467.1 - 2e-05 22.9 10.7 2e-05 22.9 7.4 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Metallophos PF00149.23 CDF89468.1 - 3.5e-08 33.0 11.1 3.5e-08 33.0 7.7 2.7 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 CDF89468.1 - 0.00015 21.6 0.0 0.0049 16.7 0.0 2.6 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Cu-oxidase_3 PF07732.10 CDF89469.1 - 2.3e-39 133.7 0.2 2.3e-39 133.7 0.2 2.8 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 CDF89469.1 - 1.4e-37 128.2 6.5 1.5e-33 115.2 0.3 3.6 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.17 CDF89469.1 - 1.5e-31 109.4 1.8 1.9e-30 105.8 0.1 3.0 3 1 0 3 3 3 1 Multicopper oxidase SET PF00856.23 CDF89470.1 - 3.1e-08 34.0 0.0 7.5e-08 32.8 0.0 1.6 2 0 0 2 2 2 1 SET domain Cofilin_ADF PF00241.15 CDF89471.1 - 3.3e-44 149.8 0.1 3.8e-44 149.6 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein CBM_4_9 PF02018.12 CDF89471.1 - 0.02 14.9 0.1 0.069 13.1 0.0 1.7 2 0 0 2 2 2 0 Carbohydrate binding domain DUF4477 PF14780.1 CDF89472.1 - 0.03 13.7 2.6 1.8 7.8 0.0 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4477) DUF904 PF06005.7 CDF89472.1 - 0.055 13.7 0.3 0.055 13.7 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF904) Borrelia_lipo_1 PF05714.6 CDF89472.1 - 0.06 12.4 1.6 0.12 11.4 1.1 1.6 1 1 0 1 1 1 0 Borrelia burgdorferi virulent strain associated lipoprotein Dynamitin PF04912.9 CDF89472.1 - 0.072 11.8 1.5 1.8 7.2 0.1 2.3 1 1 1 2 2 2 0 Dynamitin DUF4298 PF14131.1 CDF89472.1 - 0.1 12.4 0.6 4 7.3 0.0 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4298) AA_permease_2 PF13520.1 CDF89474.1 - 5.5e-60 203.1 40.1 6.7e-60 202.8 27.8 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CDF89474.1 - 8.6e-13 47.4 35.9 1.3e-12 46.8 24.9 1.1 1 0 0 1 1 1 1 Amino acid permease ABC_tran PF00005.22 CDF89475.1 - 1.5e-57 193.7 0.1 5.6e-34 117.3 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.18 CDF89475.1 - 5.5e-50 170.3 47.8 2.5e-36 125.4 5.9 4.1 5 0 0 5 5 4 3 ABC transporter transmembrane region AAA_21 PF13304.1 CDF89475.1 - 4.8e-11 43.1 6.2 0.00014 21.9 0.0 5.0 3 1 0 3 3 3 2 AAA domain AAA_23 PF13476.1 CDF89475.1 - 2.4e-09 37.8 5.6 3.3e-05 24.2 0.2 3.1 3 0 0 3 3 2 2 AAA domain SMC_N PF02463.14 CDF89475.1 - 1.3e-08 34.3 6.0 0.00051 19.3 1.0 4.3 4 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 CDF89475.1 - 8.1e-08 31.6 0.4 0.0019 17.7 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 CDF89475.1 - 5.9e-06 25.5 0.0 0.085 12.0 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Miro PF08477.8 CDF89475.1 - 6.6e-06 26.6 0.0 0.23 11.9 0.0 3.1 2 0 0 2 2 2 2 Miro-like protein T2SE PF00437.15 CDF89475.1 - 7.9e-06 24.9 0.1 0.0036 16.2 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein MMR_HSR1 PF01926.18 CDF89475.1 - 1.3e-05 25.0 0.1 0.021 14.7 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.1 CDF89475.1 - 1.5e-05 25.0 0.5 0.078 12.9 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 CDF89475.1 - 1.7e-05 24.9 0.1 0.64 10.1 0.0 3.3 2 1 0 2 2 2 2 AAA domain AAA_17 PF13207.1 CDF89475.1 - 2.4e-05 25.1 0.0 0.15 12.8 0.0 3.0 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.18 CDF89475.1 - 0.00023 21.0 1.6 0.16 11.7 0.1 2.9 3 0 0 3 3 2 2 Dynamin family Zeta_toxin PF06414.7 CDF89475.1 - 0.00025 20.2 0.1 0.56 9.2 0.0 2.9 3 0 0 3 3 3 2 Zeta toxin AAA PF00004.24 CDF89475.1 - 0.00031 20.9 0.0 0.55 10.4 0.0 3.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATP_bind_1 PF03029.12 CDF89475.1 - 0.0007 19.2 0.0 3.5 7.1 0.0 3.5 3 0 0 3 3 3 1 Conserved hypothetical ATP binding protein DUF87 PF01935.12 CDF89475.1 - 0.00073 19.4 1.2 0.61 9.8 0.0 2.8 2 0 0 2 2 2 2 Domain of unknown function DUF87 MobB PF03205.9 CDF89475.1 - 0.00098 18.8 0.9 1.4 8.6 0.1 2.5 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.1 CDF89475.1 - 0.0011 18.3 0.0 0.73 9.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.1 CDF89475.1 - 0.0012 17.9 1.0 1.2 8.1 0.1 2.9 2 1 0 2 2 2 2 AAA ATPase domain AAA_10 PF12846.2 CDF89475.1 - 0.0016 17.9 0.4 0.36 10.2 0.1 3.3 3 0 0 3 3 3 1 AAA-like domain FtsK_SpoIIIE PF01580.13 CDF89475.1 - 0.0019 17.7 0.1 2.2 7.6 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_24 PF13479.1 CDF89475.1 - 0.0033 17.0 0.5 0.78 9.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain cobW PF02492.14 CDF89475.1 - 0.0058 16.0 0.6 1 8.7 0.1 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.1 CDF89475.1 - 0.011 15.9 0.8 6.3 7.1 0.0 2.9 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.1 CDF89475.1 - 0.011 15.5 0.0 2.1 8.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain Guanylate_kin PF00625.16 CDF89475.1 - 0.035 13.5 0.4 1.3 8.4 0.0 2.8 3 0 0 3 3 2 0 Guanylate kinase AAA_30 PF13604.1 CDF89475.1 - 0.039 13.5 0.0 8 5.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.4 CDF89475.1 - 0.051 12.2 0.2 2.1 6.8 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Adeno_IVa2 PF02456.10 CDF89475.1 - 0.054 12.1 0.0 0.49 8.9 0.0 2.1 2 0 0 2 2 2 0 Adenovirus IVa2 protein ArgK PF03308.11 CDF89475.1 - 0.079 11.7 0.1 0.18 10.5 0.1 1.5 1 0 0 1 1 1 0 ArgK protein AAA_19 PF13245.1 CDF89475.1 - 0.12 12.1 0.3 2.4 7.9 0.0 2.5 2 0 0 2 2 2 0 Part of AAA domain AAA_5 PF07728.9 CDF89475.1 - 0.17 11.6 0.5 19 4.9 0.1 3.0 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 CDF89475.1 - 0.21 10.7 0.1 8.2 5.5 0.0 2.6 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI RRM_1 PF00076.17 CDF89476.1 - 5.5e-21 73.9 1.6 1.7e-10 40.3 0.1 3.5 2 2 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF89476.1 - 3.1e-12 46.2 0.3 1.9e-05 24.5 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF89476.1 - 3.3e-05 23.6 0.1 0.11 12.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Vg_Tdu PF07545.9 CDF89476.1 - 0.02 14.3 0.0 0.036 13.5 0.0 1.4 1 0 0 1 1 1 0 Vestigial/Tondu family CPSF100_C PF13299.1 CDF89476.1 - 1.7 8.8 9.5 15 5.6 2.7 2.7 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal DDHD PF02862.12 CDF89476.1 - 3.5 7.3 10.7 2.3 7.9 4.1 2.0 2 0 0 2 2 2 0 DDHD domain DUF4557 PF15101.1 CDF89476.1 - 4.1 7.1 14.0 9.1 6.0 4.6 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4557) Ribosomal_L7Ae PF01248.21 CDF89477.1 - 1.7e-23 81.9 0.4 2.8e-23 81.2 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 CDF89477.1 - 0.0047 16.7 0.1 0.007 16.2 0.0 1.2 1 0 0 1 1 1 1 RNase P subunit Pop3 FGGY_C PF02782.11 CDF89478.1 - 3.1e-70 235.8 0.2 6e-70 234.8 0.1 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 CDF89478.1 - 7.3e-46 156.4 0.0 2.1e-37 128.7 0.0 2.9 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain MIP PF00230.15 CDF89479.1 - 2.7e-70 236.3 8.5 3.7e-70 235.9 5.9 1.1 1 0 0 1 1 1 1 Major intrinsic protein V-SNARE_C PF12352.3 CDF89480.1 - 1.1e-14 54.2 2.9 1.1e-14 54.2 2.0 3.1 3 1 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus DUF349 PF03993.7 CDF89480.1 - 0.013 15.6 1.6 0.14 12.3 0.7 2.5 1 1 1 2 2 2 0 Domain of Unknown Function (DUF349) UPF0223 PF05256.7 CDF89480.1 - 0.019 15.0 2.4 0.79 9.8 0.2 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0223) DUF3246 PF11596.3 CDF89480.1 - 0.42 9.8 2.5 0.35 10.1 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) RRF_GI PF12614.3 CDF89480.1 - 0.5 10.1 5.4 0.45 10.3 0.5 2.6 2 1 1 3 3 3 0 Ribosome recycling factor PMC2NT PF08066.7 CDF89480.1 - 1.6 9.0 11.9 0.41 10.9 0.3 3.0 2 1 1 3 3 3 0 PMC2NT (NUC016) domain MitMem_reg PF13012.1 CDF89480.1 - 5.1 7.2 10.1 0.79 9.8 0.7 2.7 1 1 2 3 3 3 0 Maintenance of mitochondrial structure and function Fer2_3 PF13085.1 CDF89482.1 - 5.9e-31 106.5 0.1 1.2e-30 105.5 0.1 1.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.1 CDF89482.1 - 1.5e-10 41.2 8.4 1.5e-10 41.2 5.8 1.9 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.1 CDF89482.1 - 1.4e-08 34.5 6.6 1.4e-08 34.5 4.6 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_18 PF13746.1 CDF89482.1 - 5.1e-06 26.8 1.2 5.1e-06 26.8 0.8 2.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.1 CDF89482.1 - 0.0002 21.5 6.7 0.039 14.2 0.5 3.0 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer2 PF00111.22 CDF89482.1 - 0.0004 20.0 5.4 0.0039 16.9 1.1 2.5 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_10 PF13237.1 CDF89482.1 - 0.0044 16.7 8.6 0.0044 16.7 5.9 2.4 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.2 CDF89482.1 - 0.008 16.5 7.6 0.008 16.5 5.2 2.5 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer4_15 PF13459.1 CDF89482.1 - 6.8 7.3 8.7 1.5 9.4 0.1 2.8 3 0 0 3 3 3 0 4Fe-4S single cluster domain Fer4_4 PF12800.2 CDF89482.1 - 9.3 6.8 16.8 1.8 9.0 1.7 3.6 3 0 0 3 3 3 0 4Fe-4S binding domain DUF1162 PF06650.7 CDF89483.1 - 6.3e-84 281.4 4.1 1.4e-80 270.4 0.1 4.4 4 1 0 4 4 4 2 Protein of unknown function (DUF1162) Chorein_N PF12624.2 CDF89483.1 - 1e-39 134.7 0.1 3.4e-39 133.0 0.0 2.0 1 0 0 1 1 1 1 N-terminal region of Chorein, a TM vesicle-mediated sorter Ecm29 PF13001.2 CDF89484.1 - 9.5e-131 436.7 1.3 8.9e-128 426.9 0.3 2.4 2 0 0 2 2 2 2 Proteasome stabiliser HEAT PF02985.17 CDF89484.1 - 4e-15 54.4 5.9 0.045 13.8 0.0 9.8 10 0 0 10 10 10 2 HEAT repeat Vac14_Fab1_bd PF12755.2 CDF89484.1 - 2.6e-10 40.5 1.5 0.0018 18.6 0.0 6.2 4 2 2 6 6 6 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.1 CDF89484.1 - 0.00015 22.1 0.1 24 5.5 0.0 7.1 6 1 1 7 7 7 1 HEAT-like repeat DUF1546 PF07571.8 CDF89484.1 - 0.00019 21.4 0.3 9.3 6.4 0.0 5.5 5 1 0 6 6 6 2 Protein of unknown function (DUF1546) ENTH PF01417.15 CDF89486.1 - 1.8e-26 92.4 1.3 2.3e-26 92.0 0.2 1.7 3 0 0 3 3 3 1 ENTH domain Prp19 PF08606.6 CDF89487.1 - 8.9e-30 102.2 1.7 1.8e-29 101.2 1.2 1.6 1 0 0 1 1 1 1 Prp19/Pso4-like U-box PF04564.10 CDF89487.1 - 3.1e-05 23.8 0.2 0.00013 21.8 0.0 2.1 2 0 0 2 2 2 1 U-box domain zf-Nse PF11789.3 CDF89487.1 - 0.0096 15.4 0.1 0.024 14.1 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit RabGAP-TBC PF00566.13 CDF89488.1 - 4.1e-07 29.7 1.6 0.016 14.7 0.1 3.4 4 0 0 4 4 4 2 Rab-GTPase-TBC domain Aldo_ket_red PF00248.16 CDF89489.1 - 8e-38 129.8 0.0 1e-37 129.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Pkinase PF00069.20 CDF89490.1 - 1.7e-48 165.0 0.2 4.6e-47 160.3 0.1 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF89490.1 - 4.2e-24 85.0 0.1 1.9e-21 76.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 CDF89490.1 - 1.3e-09 37.5 0.0 1.7e-09 37.1 0.0 1.4 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 CDF89490.1 - 0.0086 15.8 0.1 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 CDF89490.1 - 0.069 12.7 0.6 0.24 10.9 0.4 2.1 2 1 0 2 2 2 0 Choline/ethanolamine kinase AAA_18 PF13238.1 CDF89491.1 - 2.2e-10 40.9 0.1 7.8e-10 39.1 0.0 1.9 1 1 1 2 2 2 1 AAA domain APS_kinase PF01583.15 CDF89491.1 - 5.7e-09 35.8 0.0 6.6e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase SKI PF01202.17 CDF89491.1 - 3.3e-07 30.3 0.0 4.2e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Shikimate kinase AAA_17 PF13207.1 CDF89491.1 - 9.9e-07 29.6 0.0 1.2e-06 29.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CDF89491.1 - 1e-05 25.4 0.0 1.4e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.12 CDF89491.1 - 0.0016 17.8 0.1 0.18 11.1 0.0 2.1 2 0 0 2 2 2 1 Thymidylate kinase Zeta_toxin PF06414.7 CDF89491.1 - 0.0025 16.9 0.0 0.0042 16.2 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin Guanylate_kin PF00625.16 CDF89491.1 - 0.0032 16.9 0.1 0.08 12.3 0.0 2.2 2 1 0 2 2 2 1 Guanylate kinase DUF258 PF03193.11 CDF89491.1 - 0.01 15.0 0.0 0.028 13.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_28 PF13521.1 CDF89491.1 - 0.01 15.7 0.3 0.1 12.5 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.1 CDF89491.1 - 0.015 15.0 0.0 0.029 14.1 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain AAA_22 PF13401.1 CDF89491.1 - 0.017 15.2 0.0 0.024 14.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 CDF89491.1 - 0.018 14.9 0.0 0.038 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain DUF2075 PF09848.4 CDF89491.1 - 0.027 13.4 0.0 0.05 12.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Sigma54_activat PF00158.21 CDF89491.1 - 0.04 13.4 0.0 0.086 12.3 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.22 CDF89491.1 - 0.054 13.7 0.1 0.065 13.5 0.1 1.5 1 1 0 1 1 1 0 ABC transporter NB-ARC PF00931.17 CDF89491.1 - 0.066 12.0 0.0 0.13 11.1 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_29 PF13555.1 CDF89491.1 - 0.068 12.7 0.1 0.12 11.8 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.24 CDF89491.1 - 0.1 12.8 0.2 0.16 12.1 0.1 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 CDF89491.1 - 0.1 12.4 0.0 0.41 10.5 0.0 1.9 2 1 1 3 3 3 0 AAA domain AAA_30 PF13604.1 CDF89491.1 - 0.11 12.1 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 CDF89491.1 - 0.12 12.5 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase CPT PF07931.7 CDF89491.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.7 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein T2SE PF00437.15 CDF89491.1 - 0.14 11.0 0.0 0.24 10.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein KAP_NTPase PF07693.9 CDF89491.1 - 0.16 10.9 0.2 1.6 7.6 0.0 1.9 1 1 1 2 2 2 0 KAP family P-loop domain MobB PF03205.9 CDF89491.1 - 0.16 11.6 0.5 0.47 10.1 0.0 1.9 2 1 1 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B Thiolase_N PF00108.18 CDF89492.1 - 1.7e-100 335.3 2.5 2.3e-100 334.9 1.8 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 CDF89492.1 - 4.7e-46 155.2 0.8 1.6e-45 153.4 0.1 2.1 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 CDF89492.1 - 0.00041 19.8 3.2 0.00054 19.5 1.8 1.6 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SUV3_C PF12513.3 CDF89493.1 - 5.3e-14 51.3 2.7 1.5e-13 49.9 1.9 1.8 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.26 CDF89493.1 - 7.8e-13 48.0 0.0 1.7e-12 46.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Nup84_Nup100 PF04121.8 CDF89494.1 - 2.1e-218 726.4 14.9 2.4e-218 726.2 10.4 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 Lipocalin PF00061.18 CDF89494.1 - 0.048 13.6 0.6 0.13 12.2 0.4 1.7 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family SH3_1 PF00018.23 CDF89495.1 - 5.1e-06 25.7 0.2 1.6e-05 24.2 0.0 1.9 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.1 CDF89495.1 - 1.2e-05 24.7 0.1 3e-05 23.5 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain Transglut_core PF01841.14 CDF89495.1 - 3.3e-05 24.0 0.0 6.2e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily SH3_2 PF07653.12 CDF89495.1 - 3.7e-05 23.1 0.1 7.3e-05 22.1 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain EDR1 PF14381.1 CDF89495.1 - 0.13 11.8 0.3 0.27 10.7 0.0 1.6 2 0 0 2 2 2 0 Ethylene-responsive protein kinase Le-CTR1 Chorismate_synt PF01264.16 CDF89496.1 - 2.6e-136 453.6 0.0 3e-136 453.4 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase SNF2_N PF00176.18 CDF89497.1 - 5.4e-72 242.1 1.8 1.4e-71 240.7 1.2 1.8 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.1 CDF89497.1 - 1.6e-52 177.2 21.9 1.6e-52 177.2 15.2 3.9 4 0 0 4 4 4 1 DNA-binding domain Helicase_C PF00271.26 CDF89497.1 - 2.5e-13 49.6 0.0 7.4e-13 48.1 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Pex14_N PF04695.8 CDF89498.1 - 1.2e-32 112.8 0.3 1.2e-32 112.8 0.2 3.2 2 2 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Pecanex_C PF05041.10 CDF89498.1 - 0.003 16.6 2.5 0.0055 15.7 1.8 1.3 1 0 0 1 1 1 1 Pecanex protein (C-terminus) DUF1664 PF07889.7 CDF89498.1 - 0.0085 15.8 3.4 0.016 15.0 1.5 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) LURAP PF14854.1 CDF89498.1 - 0.05 13.3 0.2 0.11 12.1 0.1 1.6 1 0 0 1 1 1 0 Leucine rich adaptor protein DUF342 PF03961.8 CDF89498.1 - 0.45 8.8 8.6 0.85 7.9 5.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Phage_GPO PF05929.6 CDF89498.1 - 0.65 9.1 7.9 0.72 9.0 3.5 2.0 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase ALMT PF11744.3 CDF89498.1 - 1 7.9 5.2 1 7.9 3.0 1.4 1 1 0 1 1 1 0 Aluminium activated malate transporter APG6 PF04111.7 CDF89498.1 - 1.4 7.8 15.4 2.3 7.1 10.6 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 Syntaxin-6_N PF09177.6 CDF89498.1 - 2.3 8.6 9.6 0.77 10.2 3.8 2.3 2 1 1 3 3 3 0 Syntaxin 6, N-terminal CHD5 PF04420.9 CDF89498.1 - 5.9 6.5 7.1 2.4 7.8 2.3 2.1 1 1 2 3 3 3 0 CHD5-like protein V_ATPase_I PF01496.14 CDF89498.1 - 6.5 4.4 14.8 78 0.9 10.3 1.9 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Nsp1_C PF05064.8 CDF89498.1 - 8.8 6.0 16.3 16 5.1 2.3 3.4 1 1 2 3 3 3 0 Nsp1-like C-terminal region ACPS PF01648.15 CDF89499.1 - 5.2e-09 35.9 0.0 1.3e-08 34.6 0.0 1.7 1 1 1 2 2 2 1 4'-phosphopantetheinyl transferase superfamily Mito_carr PF00153.22 CDF89500.1 - 3.6e-52 174.0 5.6 7.6e-21 73.6 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Prenyltrans PF00432.16 CDF89501.1 - 1e-33 114.5 3.7 4.3e-07 29.3 0.0 6.0 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 CDF89501.1 - 1.7e-15 57.3 0.0 0.00044 20.6 0.0 3.4 1 1 2 3 3 3 3 Prenyltransferase-like Prenyltrans_1 PF13243.1 CDF89501.1 - 0.00021 21.2 0.0 0.024 14.6 0.0 2.5 2 1 0 2 2 2 2 Prenyltransferase-like Glyco_hydro_38 PF01074.17 CDF89502.1 - 7.8e-84 281.1 0.8 1.7e-83 280.0 0.5 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.8 CDF89502.1 - 2e-65 221.3 2.2 2.7e-65 220.9 1.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.6 CDF89502.1 - 8.7e-24 83.5 0.0 2.4e-23 82.1 0.0 1.8 1 0 0 1 1 1 1 Alpha mannosidase, middle domain Frataxin_Cyay PF01491.11 CDF89503.1 - 4.8e-33 113.2 0.0 6.2e-33 112.8 0.0 1.1 1 0 0 1 1 1 1 Frataxin-like domain SNF2_assoc PF08455.5 CDF89504.1 - 0.0043 15.6 0.0 0.0045 15.6 0.0 1.1 1 0 0 1 1 1 1 Bacterial SNF2 helicase associated UCH PF00443.24 CDF89505.1 - 9.1e-46 156.1 0.2 1.1e-45 155.8 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CDF89505.1 - 2.7e-15 56.5 1.5 8.3e-14 51.7 1.1 2.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF1528 PF07515.6 CDF89505.1 - 0.088 12.8 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1528) RRM_1 PF00076.17 CDF89506.1 - 7.3e-55 182.5 0.4 2.2e-19 68.8 0.2 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF89506.1 - 5.6e-29 99.9 0.3 5.4e-10 39.1 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF89506.1 - 4.1e-27 93.7 1.7 8.8e-08 31.8 0.3 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CDF89506.1 - 0.00036 20.2 0.2 0.12 12.1 0.0 3.0 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif DUF3421 PF11901.3 CDF89506.1 - 0.0067 16.1 0.1 1.6 8.4 0.0 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF3421) Cas_Cas2CT1978 PF09707.5 CDF89506.1 - 0.05 13.5 0.1 7.9 6.5 0.0 2.4 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) DUF1987 PF09345.5 CDF89506.1 - 0.16 11.8 0.5 9.2 6.1 0.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF1987) DFP PF04127.10 CDF89507.1 - 7.5e-16 58.2 0.0 5.7e-07 29.3 0.0 2.8 2 1 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein Bac_surface_Ag PF01103.18 CDF89508.1 - 1.7e-42 146.0 1.9 2.2e-42 145.6 1.3 1.1 1 0 0 1 1 1 1 Surface antigen zf-H2C2_2 PF13465.1 CDF89509.1 - 6.6e-16 57.7 10.0 1.8e-09 37.4 0.3 4.3 4 1 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.21 CDF89509.1 - 1.8e-14 53.1 10.5 7.1e-07 29.1 1.0 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CDF89509.1 - 3.2e-12 45.8 10.4 0.00011 22.2 0.9 4.4 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CDF89509.1 - 6.9e-08 32.4 5.6 0.00032 20.7 0.2 3.7 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CDF89509.1 - 7.6e-08 32.2 2.8 3.1e-05 24.0 0.2 3.1 3 0 0 3 3 3 2 Zinc-finger of C2H2 type Zn_ribbon_recom PF13408.1 CDF89509.1 - 0.0015 18.7 1.6 0.0015 18.7 1.1 2.1 2 0 0 2 2 2 1 Recombinase zinc beta ribbon domain zf-C2H2_6 PF13912.1 CDF89509.1 - 0.014 15.2 5.5 2.1 8.3 0.2 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger FYVE PF01363.16 CDF89509.1 - 0.23 11.4 4.9 0.5 10.2 3.4 1.6 1 0 0 1 1 1 0 FYVE zinc finger C1_4 PF07975.7 CDF89509.1 - 1.5 8.8 4.1 16 5.5 2.4 2.5 1 1 1 2 2 2 0 TFIIH C1-like domain zf-H2C2_5 PF13909.1 CDF89509.1 - 2.1 8.7 4.9 1.3 9.3 0.7 2.8 3 0 0 3 3 2 0 C2H2-type zinc-finger domain zf-C2HC_2 PF13913.1 CDF89509.1 - 2.9 7.6 8.0 5.9 6.6 0.1 3.0 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-BED PF02892.10 CDF89509.1 - 3.2 7.5 8.7 3.1 7.6 0.4 3.5 2 1 1 3 3 3 0 BED zinc finger Met_10 PF02475.11 CDF89510.1 - 4.7e-13 49.1 0.0 1.9e-12 47.2 0.0 1.9 1 1 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.10 CDF89510.1 - 3.6e-05 23.2 0.0 7.4e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_26 PF13659.1 CDF89510.1 - 0.00085 19.3 0.0 0.0018 18.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CDF89510.1 - 0.0031 16.9 0.0 0.019 14.3 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain Sds3 PF08598.6 CDF89511.1 - 1.3e-58 197.9 5.0 1.8e-58 197.4 3.4 1.2 1 0 0 1 1 1 1 Sds3-like FAD-SLDH PF12318.3 CDF89511.1 - 5.3 6.7 5.7 0.63 9.7 0.1 2.3 3 0 0 3 3 3 0 Membrane bound FAD containing D-sorbitol dehydrogenase DUF2416 PF10315.4 CDF89512.1 - 5.2e-37 126.3 0.6 7.5e-37 125.8 0.4 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF2416) Tmemb_14 PF03647.8 CDF89512.1 - 0.067 13.6 1.0 0.13 12.6 0.2 1.8 2 1 0 2 2 2 0 Transmembrane proteins 14C Y_phosphatase2 PF03162.8 CDF89513.1 - 2.3e-63 212.4 0.0 3.1e-63 212.0 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 CDF89513.1 - 2.8e-07 30.9 0.0 4.2e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.15 CDF89513.1 - 0.0021 17.6 0.0 0.0028 17.2 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 CDF89513.1 - 0.0031 16.9 0.0 0.0046 16.3 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Aa_trans PF01490.13 CDF89514.1 - 3.2e-109 365.1 20.6 3.8e-109 364.8 14.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2561 PF10812.3 CDF89514.1 - 0.034 13.7 0.2 0.14 11.7 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2561) Cyclin_N PF00134.18 CDF89515.1 - 2.1e-17 62.8 2.0 6.1e-17 61.3 0.2 2.4 2 1 0 3 3 3 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 CDF89515.1 - 0.00079 19.3 1.5 0.029 14.2 0.2 2.5 2 1 0 2 2 2 2 Cyclin, C-terminal domain ICE2 PF08426.5 CDF89516.1 - 1.8e-158 527.5 28.2 2.1e-158 527.3 19.6 1.0 1 0 0 1 1 1 1 ICE2 EutH PF04346.7 CDF89516.1 - 0.0011 18.0 0.3 0.0022 16.9 0.2 1.4 1 0 0 1 1 1 1 Ethanolamine utilisation protein, EutH DUF1253 PF06862.7 CDF89517.1 - 2.2e-159 530.6 3.0 3.6e-159 529.8 2.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1253) DEAD PF00270.24 CDF89517.1 - 0.00028 20.4 0.0 0.48 9.8 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase DUF1242 PF06842.7 CDF89518.1 - 9.5e-19 66.6 0.9 1.2e-18 66.2 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) DUF2366 PF10171.4 CDF89518.1 - 0.024 14.1 0.1 0.033 13.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2366) MRP-S25 PF13741.1 CDF89519.1 - 6.8e-91 303.8 5.7 8e-91 303.6 4.0 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.4 CDF89519.1 - 8.1e-06 25.7 0.8 0.00017 21.4 0.1 2.6 1 1 1 2 2 2 1 Mitochondrial ribosomal protein S23 R3H PF01424.17 CDF89520.1 - 8.2e-14 51.0 0.0 2e-13 49.8 0.0 1.6 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.12 CDF89520.1 - 9.9e-09 34.9 57.3 5.4e-05 23.0 11.2 12.2 10 1 0 10 10 10 5 NF-X1 type zinc finger Nol1_Nop2_Fmu PF01189.12 CDF89521.1 - 2.9e-18 66.2 0.1 1.1e-17 64.3 0.0 2.0 1 1 0 1 1 1 1 NOL1/NOP2/sun family Pkinase PF00069.20 CDF89522.1 - 5.3e-38 130.6 0.0 9.3e-38 129.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF89522.1 - 1.1e-27 96.8 0.0 1.6e-27 96.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF89522.1 - 0.0014 17.6 0.0 0.003 16.5 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.9 CDF89522.1 - 0.0019 17.3 0.3 0.022 13.8 0.0 2.3 3 0 0 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CDF89522.1 - 0.07 12.8 0.0 0.39 10.4 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family WD40 PF00400.27 CDF89523.1 - 1.4e-10 40.6 1.5 0.00048 19.8 0.1 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat tRNA-synt_2c PF01411.14 CDF89524.1 - 1.1e-06 27.2 0.4 3.7e-06 25.5 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class II (A) tRNA_SAD PF07973.9 CDF89524.1 - 2e-06 27.5 0.0 4.4e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Myb_DNA-binding PF00249.26 CDF89525.1 - 2.3e-06 27.5 0.0 7.3e-06 25.9 0.0 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CDF89525.1 - 0.022 14.8 0.0 0.1 12.7 0.0 2.2 1 0 0 1 1 1 0 Myb-like DNA-binding domain PIG-H PF10181.4 CDF89526.1 - 8e-17 60.6 0.1 1.6e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component DUF2431 PF10354.4 CDF89527.1 - 9.5e-58 194.8 0.5 1.4e-57 194.2 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) CLTH PF10607.4 CDF89528.1 - 3.2e-27 94.9 0.8 3.2e-27 94.9 0.5 2.3 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain Iso_dh PF00180.15 CDF89529.1 - 8.8e-76 255.0 1.0 1.1e-75 254.7 0.7 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase EamA PF00892.15 CDF89531.1 - 2.6e-26 92.0 22.5 1.3e-15 57.5 4.4 2.5 2 0 0 2 2 2 2 EamA-like transporter family EmrE PF13536.1 CDF89531.1 - 5e-09 36.3 6.4 5e-09 36.3 4.4 3.3 2 1 1 3 3 3 1 Multidrug resistance efflux transporter UAA PF08449.6 CDF89531.1 - 0.012 14.5 8.9 0.053 12.4 0.1 2.5 2 1 0 2 2 2 0 UAA transporter family DUF914 PF06027.7 CDF89531.1 - 0.077 11.8 6.5 0.11 11.3 4.5 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF914) TPT PF03151.11 CDF89531.1 - 0.088 12.4 16.5 0.061 12.9 4.5 3.1 2 2 0 2 2 2 0 Triose-phosphate Transporter family EamA PF00892.15 CDF89532.1 - 6.3e-26 90.8 21.7 1.1e-15 57.8 2.5 3.0 2 1 1 3 3 3 2 EamA-like transporter family EmrE PF13536.1 CDF89532.1 - 1.7e-09 37.8 6.2 1.7e-09 37.8 4.3 3.6 2 1 1 3 3 3 2 Multidrug resistance efflux transporter TPT PF03151.11 CDF89532.1 - 0.0038 16.8 6.6 0.0038 16.8 4.6 2.5 2 1 0 2 2 2 1 Triose-phosphate Transporter family DUF1129 PF06570.6 CDF89532.1 - 1 8.6 6.2 3.7 6.8 0.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) EamA PF00892.15 CDF89533.1 - 2.4e-25 89.0 23.6 2.2e-14 53.5 3.2 2.4 2 1 0 2 2 2 2 EamA-like transporter family EmrE PF13536.1 CDF89533.1 - 6.2e-09 36.0 5.6 6.2e-09 36.0 3.9 3.5 2 1 1 3 3 3 2 Multidrug resistance efflux transporter TPT PF03151.11 CDF89533.1 - 0.025 14.2 16.1 0.017 14.7 3.7 3.0 2 1 0 2 2 2 0 Triose-phosphate Transporter family ABC2_membrane_5 PF13346.1 CDF89533.1 - 10 5.3 12.4 2.4 7.4 3.0 2.5 2 0 0 2 2 2 0 ABC-2 family transporter protein zf-C3HC4_4 PF15227.1 CDF89537.1 - 8.1e-10 38.4 10.9 8.1e-10 38.4 7.6 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.20 CDF89537.1 - 3e-09 36.3 10.0 3e-09 36.3 6.9 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDF89537.1 - 4.1e-09 36.3 9.7 4.1e-09 36.3 6.7 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CDF89537.1 - 6.5e-08 32.2 9.5 6.5e-08 32.2 6.6 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.1 CDF89537.1 - 1.9e-07 30.6 13.2 4.6e-07 29.3 3.5 2.2 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 CDF89537.1 - 6.2e-07 29.0 2.4 1.4e-06 27.9 1.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.1 CDF89537.1 - 1.1e-05 24.9 8.5 1.1e-05 24.9 5.9 2.6 2 1 0 2 2 2 1 zinc-RING finger domain DZR PF12773.2 CDF89537.1 - 0.00045 19.9 10.4 0.13 12.1 0.2 2.5 2 0 0 2 2 2 2 Double zinc ribbon zf-UDP PF14569.1 CDF89537.1 - 0.00076 19.1 10.7 0.041 13.6 0.4 3.1 3 0 0 3 3 2 2 Zinc-binding RING-finger zf-rbx1 PF12678.2 CDF89537.1 - 0.00091 19.2 4.4 0.00091 19.2 3.1 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger zf-Apc11 PF12861.2 CDF89537.1 - 0.0045 16.8 2.6 0.0045 16.8 1.8 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-MIZ PF02891.15 CDF89537.1 - 0.0084 15.6 6.9 0.0084 15.6 4.8 2.1 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-RING_4 PF14570.1 CDF89537.1 - 0.026 14.0 16.0 0.47 10.0 6.0 3.0 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_3 PF14369.1 CDF89537.1 - 0.098 12.6 18.3 0.19 11.7 2.2 4.0 3 1 1 4 4 4 0 zinc-finger HypA PF01155.14 CDF89537.1 - 0.28 10.8 6.8 2.7 7.7 0.1 2.3 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family zinc_ribbon_2 PF13240.1 CDF89537.1 - 0.65 9.5 12.1 0.083 12.4 0.6 3.5 3 1 0 3 3 3 0 zinc-ribbon domain Zn_ribbon_recom PF13408.1 CDF89537.1 - 0.8 10.0 6.7 12 6.2 0.6 3.3 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain FANCL_C PF11793.3 CDF89537.1 - 1.8 8.6 10.1 25 4.8 5.3 3.0 2 1 0 2 2 2 0 FANCL C-terminal domain DUF2428 PF10350.4 CDF89540.1 - 4.6e-61 206.0 0.6 1.2e-60 204.7 0.1 2.0 2 0 0 2 2 2 1 Putative death-receptor fusion protein (DUF2428) HEAT_2 PF13646.1 CDF89540.1 - 3.1e-07 30.5 0.1 0.002 18.3 0.1 4.2 3 1 1 4 4 4 2 HEAT repeats HEAT PF02985.17 CDF89540.1 - 1.6e-06 27.6 0.5 0.59 10.3 0.0 5.5 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.1 CDF89540.1 - 0.0017 18.8 0.0 0.09 13.2 0.0 3.6 4 0 0 4 4 4 1 HEAT-like repeat ATP-sulfurylase PF01747.12 CDF89540.1 - 0.15 11.3 0.0 0.29 10.4 0.0 1.4 1 0 0 1 1 1 0 ATP-sulfurylase eIF-1a PF01176.14 CDF89541.1 - 9.4e-27 92.2 0.1 1.3e-26 91.8 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Myb_DNA-bind_6 PF13921.1 CDF89541.1 - 0.08 13.0 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain Glyco_transf_20 PF00982.16 CDF89542.1 - 9.7e-168 558.5 0.1 1.4e-167 558.0 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 CDF89542.1 - 6.8e-39 133.1 0.0 1.6e-38 131.9 0.0 1.5 1 0 0 1 1 1 1 Trehalose-phosphatase TatD_DNase PF01026.16 CDF89543.1 - 9.3e-36 123.3 0.0 1.3e-35 122.8 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase SAP30_Sin3_bdg PF13867.1 CDF89544.1 - 1.3e-12 47.3 1.1 9e-10 38.2 0.1 2.3 1 1 1 2 2 2 2 Sin3 binding region of histone deacetylase complex subunit SAP30 CUE PF02845.11 CDF89545.1 - 8.9e-09 34.6 0.0 2.2e-08 33.4 0.0 1.7 1 0 0 1 1 1 1 CUE domain DNApol3-delta_C PF09115.5 CDF89545.1 - 0.0033 17.4 3.1 0.24 11.4 0.4 2.5 2 1 1 3 3 3 2 DNA polymerase III, delta subunit, C terminal WD40 PF00400.27 CDF89546.1 - 1.4e-32 110.3 0.3 2.1e-06 27.3 0.0 5.8 5 0 0 5 5 5 5 WD domain, G-beta repeat eIF2A PF08662.6 CDF89546.1 - 0.00039 20.2 0.4 0.047 13.3 0.1 3.2 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 CDF89546.1 - 0.0086 14.2 0.0 0.022 12.9 0.0 1.6 1 1 0 1 1 1 1 Nucleoporin Nup120/160 DUF2410 PF10307.4 CDF89547.1 - 7.8e-49 165.7 0.0 1.2e-48 165.1 0.0 1.3 1 0 0 1 1 1 1 Hypothetical protein (DUF2410) DUF221 PF02714.10 CDF89548.1 - 1.1e-105 353.0 23.2 1.1e-105 353.0 16.1 1.6 2 0 0 2 2 2 1 Domain of unknown function DUF221 RSN1_TM PF13967.1 CDF89548.1 - 1.8e-38 131.5 1.1 1.8e-38 131.5 0.7 2.8 2 1 0 2 2 2 1 Late exocytosis, associated with Golgi transport DUF3779 PF12621.3 CDF89548.1 - 9.5e-28 95.9 0.0 2.2e-27 94.7 0.0 1.6 1 0 0 1 1 1 1 Phosphate metabolism protein DUF4463 PF14703.1 CDF89548.1 - 2.2e-07 31.3 0.5 4.8e-07 30.1 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4463) Tegument_dsDNA PF12818.2 CDF89548.1 - 0.011 14.5 0.2 0.02 13.7 0.1 1.3 1 0 0 1 1 1 0 dsDNA viral tegument protein Dynamin_M PF01031.15 CDF89548.1 - 0.38 9.4 0.9 4.8 5.8 0.0 2.1 2 0 0 2 2 2 0 Dynamin central region Pyrophosphatase PF00719.14 CDF89549.1 - 1.9e-51 173.6 0.0 2.5e-51 173.1 0.0 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase Nup188 PF10487.4 CDF89550.1 - 2e-210 701.2 28.7 3.2e-210 700.5 19.9 1.3 1 0 0 1 1 1 1 Nucleoporin subcomplex protein binding to Pom34 RRM_1 PF00076.17 CDF89551.1 - 2.1e-39 132.9 1.5 1.2e-13 50.4 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF89551.1 - 8.7e-31 105.7 1.4 5.1e-10 39.1 0.0 4.3 5 0 0 5 5 5 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF89551.1 - 1.8e-09 37.3 0.0 0.0054 16.5 0.0 4.4 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CDF89551.1 - 0.00012 21.7 0.0 0.0023 17.6 0.0 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Lsm_interact PF05391.6 CDF89551.1 - 0.00034 19.8 0.6 0.00034 19.8 0.4 2.1 2 0 0 2 2 2 1 Lsm interaction motif EAP30 PF04157.11 CDF89551.1 - 0.012 14.8 0.3 1.9 7.5 0.0 3.0 3 0 0 3 3 3 0 EAP30/Vps36 family SET_assoc PF11767.3 CDF89551.1 - 0.027 13.7 0.0 0.068 12.4 0.0 1.7 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated DUF2839 PF10999.3 CDF89551.1 - 0.028 14.4 0.0 0.38 10.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2839) G-patch PF01585.18 CDF89552.1 - 0.00052 19.7 4.5 0.00092 18.9 1.3 2.7 2 0 0 2 2 2 1 G-patch domain RNase_H2-Ydr279 PF09468.5 CDF89552.1 - 0.15 11.2 16.8 0.19 10.8 11.6 1.3 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) DDHD PF02862.12 CDF89552.1 - 0.51 10.0 7.8 0.58 9.9 5.4 1.2 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.7 CDF89552.1 - 1.3 8.9 15.6 1.4 8.7 10.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ndc1_Nup PF09531.5 CDF89552.1 - 3.1 6.0 5.6 4 5.7 3.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Ycf1 PF05758.7 CDF89552.1 - 5.2 4.6 19.5 5.5 4.5 13.5 1.0 1 0 0 1 1 1 0 Ycf1 Vfa1 PF08432.5 CDF89552.1 - 7 6.6 30.1 11 6.0 20.9 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PXA PF02194.10 CDF89553.1 - 2e-36 125.2 4.1 2e-36 125.2 2.9 2.3 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.7 CDF89553.1 - 2.1e-25 88.9 0.7 1.2e-24 86.6 0.1 2.6 2 0 0 2 2 2 1 Sorting nexin C terminal PX PF00787.19 CDF89553.1 - 6.6e-13 48.4 4.4 6.6e-13 48.4 3.1 2.3 2 0 0 2 2 2 1 PX domain RRN9 PF10680.4 CDF89554.1 - 7.7e-17 60.7 0.2 1.9e-16 59.5 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor SRP19 PF01922.12 CDF89555.1 - 4.4e-28 97.7 0.0 8.5e-28 96.7 0.0 1.5 1 0 0 1 1 1 1 SRP19 protein Pribosyltran PF00156.22 CDF89556.1 - 5.9e-17 61.5 0.1 1.4e-16 60.3 0.1 1.6 2 0 0 2 2 2 1 Phosphoribosyl transferase domain zf-C3HC PF07967.8 CDF89557.1 - 6.5e-10 38.8 8.7 2e-09 37.3 1.8 2.7 2 1 0 2 2 2 2 C3HC zinc finger-like Rsm1 PF08600.5 CDF89557.1 - 0.13 12.1 6.0 0.1 12.4 0.6 2.7 2 1 0 2 2 2 0 Rsm1-like Cyt-b5 PF00173.23 CDF89558.1 - 1.5e-24 85.6 1.7 5.1e-23 80.6 0.1 3.0 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.8 CDF89558.1 - 1.6e-10 41.4 15.6 1.6e-10 41.4 10.8 2.3 1 1 1 2 2 2 1 Fatty acid hydroxylase superfamily Anth_synt_I_N PF04715.8 CDF89558.1 - 0.014 15.4 0.2 0.027 14.4 0.2 1.4 1 0 0 1 1 1 0 Anthranilate synthase component I, N terminal region DUF1892 PF08987.5 CDF89559.1 - 2.2e-40 137.2 1.3 2.3e-40 137.2 0.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1892) Zds_C PF08632.5 CDF89560.1 - 8.4e-33 111.5 1.3 1.5e-32 110.7 0.9 1.4 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term Abi PF02517.11 CDF89561.1 - 2.1e-14 53.4 2.5 2.1e-14 53.4 1.7 2.4 2 0 0 2 2 2 1 CAAX protease self-immunity Ubie_methyltran PF01209.13 CDF89562.1 - 2.8e-99 330.9 0.2 3.5e-99 330.6 0.1 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.1 CDF89562.1 - 1.1e-12 47.7 0.1 1.6e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDF89562.1 - 5.4e-09 36.4 0.0 1e-08 35.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDF89562.1 - 7.6e-09 35.9 0.0 1.3e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDF89562.1 - 3e-08 33.9 0.0 5e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDF89562.1 - 2.6e-06 27.9 0.0 4.6e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDF89562.1 - 3e-06 27.0 0.0 4.8e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CDF89562.1 - 0.0026 17.7 0.0 0.021 14.8 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_28 PF02636.12 CDF89562.1 - 0.018 14.4 0.0 0.054 12.8 0.0 1.7 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_32 PF13679.1 CDF89562.1 - 0.032 13.9 0.0 0.054 13.1 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain Bul1_N PF04425.7 CDF89563.1 - 8.6e-161 535.3 1.4 8.6e-161 535.3 1.0 2.2 2 0 0 2 2 2 1 Bul1 N terminus Bul1_C PF04426.7 CDF89563.1 - 7.8e-105 349.9 10.9 2e-104 348.5 7.6 1.7 1 0 0 1 1 1 1 Bul1 C terminus CTK3_C PF12350.3 CDF89564.1 - 8.7e-22 76.9 0.1 3.6e-21 74.9 0.0 2.1 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 C-terminus CTK3 PF12243.3 CDF89564.1 - 5.3e-08 32.6 0.4 9.4e-08 31.7 0.3 1.4 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 DUF2126 PF09899.4 CDF89564.1 - 0.035 12.1 0.1 0.038 12.0 0.0 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) YvfG PF09628.5 CDF89564.1 - 0.046 13.8 0.3 8.5 6.6 0.2 2.6 2 0 0 2 2 2 0 YvfG protein ubiquitin PF00240.18 CDF89566.1 - 1.8e-19 68.8 0.1 2.7e-19 68.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 CDF89566.1 - 1.6e-10 40.5 0.1 2.4e-10 39.9 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.26 CDF89566.1 - 2e-07 30.6 0.0 5.1e-07 29.3 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain Ubiquitin_2 PF14560.1 CDF89566.1 - 4.3e-05 23.6 0.0 8.7e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.1 CDF89566.1 - 0.00052 19.8 0.1 0.0012 18.7 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 CDF89566.1 - 0.0024 17.9 0.0 0.0039 17.3 0.0 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain YukD PF08817.5 CDF89566.1 - 0.006 17.1 0.0 0.011 16.3 0.0 1.4 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD TAF8_C PF10406.4 CDF89567.1 - 9.4e-21 73.6 6.6 1.3e-20 73.2 0.5 2.8 2 0 0 2 2 2 2 Transcription factor TFIID complex subunit 8 C-term NIF PF03031.13 CDF89568.1 - 1.4e-24 86.5 0.3 1.6e-23 83.1 0.0 2.3 1 1 0 2 2 2 1 NLI interacting factor-like phosphatase BRCT PF00533.21 CDF89568.1 - 1e-09 38.4 0.1 2.7e-09 37.0 0.1 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 CDF89568.1 - 4.8e-07 29.5 0.0 1.2e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain Dot_icm_IcmQ PF09475.5 CDF89568.1 - 0.028 13.6 0.7 1.1 8.4 0.7 2.3 2 0 0 2 2 2 0 Dot/Icm secretion system protein (dot_icm_IcmQ) PGM_PMM_I PF02878.11 CDF89569.1 - 8.5e-39 132.2 0.0 1.4e-38 131.4 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 CDF89569.1 - 2e-17 63.4 0.0 4.1e-17 62.4 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.11 CDF89569.1 - 1.6e-13 50.7 0.0 4.9e-13 49.1 0.0 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.15 CDF89569.1 - 8.8e-08 32.0 0.0 2.1e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain S-methyl_trans PF02574.11 CDF89570.1 - 9.5e-72 241.8 0.0 1.1e-71 241.7 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Anp1 PF03452.9 CDF89571.1 - 1.5e-122 408.0 0.0 1.9e-122 407.6 0.0 1.1 1 0 0 1 1 1 1 Anp1 CSS-motif PF12792.2 CDF89571.1 - 0.0057 16.0 0.0 0.0099 15.2 0.0 1.4 1 0 0 1 1 1 1 CSS motif domain associated with EAL Nab6_mRNP_bdg PF10567.4 CDF89572.1 - 4.9e-88 295.0 3.3 4.9e-88 295.0 2.3 2.2 3 0 0 3 3 3 1 RNA-recognition motif RRM PF10378.4 CDF89572.1 - 1.8e-16 59.4 4.4 1.8e-16 59.4 3.0 2.8 2 0 0 2 2 2 1 Putative RRM domain RRM_6 PF14259.1 CDF89572.1 - 3.4e-14 52.5 0.2 3.2e-06 27.0 0.0 4.5 4 0 0 4 4 4 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF89572.1 - 1.8e-11 43.7 0.4 4.9e-05 23.0 0.0 3.8 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CDF89572.1 - 2e-08 33.7 0.3 0.0027 17.3 0.0 4.4 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fungal_trans PF04082.13 CDF89573.1 - 3.4e-38 131.0 0.3 6.7e-38 130.0 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF89573.1 - 1.4e-10 40.8 12.8 2.3e-10 40.1 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AT_hook PF02178.14 CDF89573.1 - 0.039 13.6 1.1 0.12 12.0 0.8 1.9 1 0 0 1 1 1 0 AT hook motif PIG-L PF02585.12 CDF89574.1 - 2.2e-18 67.0 0.0 3.1e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase ATP13 PF12921.2 CDF89575.1 - 2.2e-30 104.5 2.1 1.2e-29 102.2 0.3 2.9 4 0 0 4 4 4 1 Mitochondrial ATPase expression TPR_16 PF13432.1 CDF89575.1 - 0.015 15.9 0.0 2.6 8.8 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.1 CDF89575.1 - 0.034 14.6 0.0 0.6 10.6 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 CDF89575.1 - 0.034 14.4 0.0 12 6.3 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Init_tRNA_PT PF04179.7 CDF89576.1 - 3.3e-149 497.6 0.1 3.7e-149 497.4 0.1 1.0 1 0 0 1 1 1 1 Initiator tRNA phosphoribosyl transferase Milton PF12448.3 CDF89576.1 - 0.15 12.2 0.0 0.82 9.8 0.0 2.0 2 0 0 2 2 2 0 Kinesin associated protein Ku_N PF03731.10 CDF89577.1 - 3.3e-30 105.1 0.4 6.5e-30 104.2 0.0 1.7 2 0 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain Ku PF02735.11 CDF89577.1 - 4.8e-29 101.2 0.7 1e-28 100.1 0.0 1.7 2 0 0 2 2 2 1 Ku70/Ku80 beta-barrel domain Ku_C PF03730.9 CDF89577.1 - 7.1e-09 36.0 3.1 2.4e-08 34.3 2.2 1.9 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm VWA PF00092.23 CDF89577.1 - 2.5e-05 24.0 0.0 4.5e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Exo_endo_phos PF03372.18 CDF89578.1 - 1e-23 84.5 0.1 1.3e-23 84.2 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ribosomal_L30 PF00327.15 CDF89579.1 - 4.6e-13 48.5 0.0 6.7e-13 48.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e RNB PF00773.14 CDF89581.1 - 3.7e-69 233.4 0.1 7.1e-69 232.5 0.1 1.5 1 0 0 1 1 1 1 RNB domain Pyr_redox_2 PF07992.9 CDF89582.1 - 1.9e-27 96.4 0.5 9.3e-18 64.8 0.0 3.7 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CDF89582.1 - 2.2e-11 43.9 0.0 5.4e-09 36.3 0.1 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CDF89582.1 - 6.2e-10 39.4 0.0 0.00015 21.9 0.0 3.5 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Cut8_C PF08559.5 CDF89582.1 - 0.0017 18.1 0.0 0.0043 16.8 0.0 1.6 1 0 0 1 1 1 1 Cut8 six-helix bundle Brix PF04427.13 CDF89583.1 - 9.3e-46 155.9 0.6 1.2e-45 155.5 0.4 1.1 1 0 0 1 1 1 1 Brix domain DUF1752 PF08550.5 CDF89584.1 - 2.6e-09 36.4 0.1 5.9e-09 35.3 0.0 1.7 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Sec5 PF15469.1 CDF89585.1 - 0.00036 20.3 11.8 0.0026 17.4 0.1 3.5 3 0 0 3 3 3 2 Exocyst complex component Sec5 DUF883 PF05957.8 CDF89585.1 - 0.077 13.4 32.4 0.38 11.1 3.5 5.0 3 3 2 5 5 5 0 Bacterial protein of unknown function (DUF883) Acyl-CoA_dh_2 PF08028.6 CDF89585.1 - 2.1 8.5 9.1 0.56 10.4 2.8 2.4 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain DUF948 PF06103.6 CDF89585.1 - 4.4 7.2 5.9 6.6 6.6 0.5 3.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DnaJ PF00226.26 CDF89586.1 - 1.1e-22 79.4 1.8 1.1e-22 79.4 1.2 1.8 2 0 0 2 2 2 1 DnaJ domain CTDII PF01556.13 CDF89586.1 - 7e-14 51.4 0.1 6.8e-13 48.3 0.0 2.5 3 0 0 3 3 3 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 CDF89586.1 - 2.2e-10 40.4 17.3 7.3e-10 38.7 12.0 1.9 1 0 0 1 1 1 1 DnaJ central domain DZR PF12773.2 CDF89586.1 - 2.5 7.9 13.8 1.7 8.5 1.3 2.5 1 1 1 2 2 2 0 Double zinc ribbon Peptidase_M1 PF01433.15 CDF89587.1 - 2.3e-95 319.9 0.0 1e-94 317.8 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M1 ERAP1_C PF11838.3 CDF89587.1 - 2e-60 204.7 0.0 2.9e-60 204.2 0.0 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_MA_2 PF13485.1 CDF89587.1 - 4.2e-13 49.4 0.1 7.8e-13 48.5 0.1 1.4 1 0 0 1 1 1 1 Peptidase MA superfamily DUF2265 PF10023.4 CDF89587.1 - 0.019 14.1 0.1 0.038 13.1 0.1 1.4 1 0 0 1 1 1 0 Predicted aminopeptidase (DUF2265) Tropomyosin_1 PF12718.2 CDF89589.1 - 8.3e-48 161.8 47.4 9.8e-48 161.6 32.8 1.1 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.15 CDF89589.1 - 1.6e-07 30.7 43.1 0.00077 18.6 11.2 2.0 1 1 1 2 2 2 2 Tropomyosin CENP-F_leu_zip PF10473.4 CDF89589.1 - 0.00019 21.3 45.4 0.00027 20.8 8.8 3.1 1 1 2 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KLRAQ PF10205.4 CDF89589.1 - 0.00019 21.3 28.1 0.0078 16.2 8.8 2.2 1 1 1 2 2 2 2 Predicted coiled-coil domain-containing protein ATG16 PF08614.6 CDF89589.1 - 0.00087 19.1 36.8 0.017 14.9 15.2 2.2 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) ADIP PF11559.3 CDF89589.1 - 0.0041 17.0 39.0 0.11 12.4 9.7 2.8 1 1 1 2 2 2 1 Afadin- and alpha -actinin-Binding Laminin_II PF06009.7 CDF89589.1 - 0.0056 16.4 24.5 0.04 13.6 7.5 2.1 1 1 1 2 2 2 2 Laminin Domain II Myosin_tail_1 PF01576.14 CDF89589.1 - 0.006 14.3 41.4 0.008 13.9 28.7 1.1 1 0 0 1 1 1 1 Myosin tail WXG100 PF06013.7 CDF89589.1 - 0.0064 16.4 14.7 0.65 10.0 0.1 3.7 2 1 1 3 3 3 1 Proteins of 100 residues with WXG Filament PF00038.16 CDF89589.1 - 0.007 15.8 34.6 0.027 13.9 9.3 2.0 1 1 1 2 2 2 2 Intermediate filament protein GAS PF13851.1 CDF89589.1 - 0.008 15.3 41.3 0.54 9.4 26.0 2.4 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding Reo_sigmaC PF04582.7 CDF89589.1 - 0.016 14.4 8.3 0.3 10.2 1.4 2.0 1 1 1 2 2 2 0 Reovirus sigma C capsid protein bZIP_1 PF00170.16 CDF89589.1 - 0.022 14.6 41.1 0.39 10.6 3.5 4.6 1 1 2 4 4 4 0 bZIP transcription factor IncA PF04156.9 CDF89589.1 - 0.04 13.5 43.0 0.21 11.1 14.8 2.0 1 1 1 2 2 2 0 IncA protein MbeD_MobD PF04899.7 CDF89589.1 - 0.041 13.7 1.8 0.041 13.7 1.2 3.0 2 1 1 3 3 3 0 MbeD/MobD like TMF_DNA_bd PF12329.3 CDF89589.1 - 0.048 13.4 51.8 0.13 12.0 12.6 3.2 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding LPP PF04728.8 CDF89589.1 - 0.058 13.1 0.8 0.68 9.7 0.3 2.7 1 1 1 2 2 2 0 Lipoprotein leucine-zipper APG6 PF04111.7 CDF89589.1 - 0.061 12.3 44.8 0.38 9.7 20.4 2.0 1 1 1 2 2 2 0 Autophagy protein Apg6 FlaC_arch PF05377.6 CDF89589.1 - 0.064 13.1 24.9 1.7 8.5 1.5 4.5 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) Mod_r PF07200.8 CDF89589.1 - 0.1 12.5 34.0 0.64 9.9 16.5 2.9 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein BLOC1_2 PF10046.4 CDF89589.1 - 0.12 12.5 30.7 0.47 10.6 7.0 3.7 1 1 2 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Nup54 PF13874.1 CDF89589.1 - 0.13 11.9 23.7 0.36 10.5 10.9 2.2 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 DUF3287 PF11690.3 CDF89589.1 - 0.15 12.1 15.8 0.049 13.6 4.0 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF3287) ERM PF00769.14 CDF89589.1 - 0.19 11.2 43.2 0.69 9.4 15.6 2.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family TelA PF05816.6 CDF89589.1 - 0.2 10.3 26.3 0.1 11.2 3.7 2.9 1 1 1 2 2 2 0 Toxic anion resistance protein (TelA) EzrA PF06160.7 CDF89589.1 - 0.29 9.2 32.3 1.2 7.2 5.5 2.3 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA DUF4200 PF13863.1 CDF89589.1 - 0.29 11.0 42.8 2.7 7.9 14.4 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF3450 PF11932.3 CDF89589.1 - 0.33 10.1 30.0 0.54 9.4 8.3 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) Sec2p PF06428.6 CDF89589.1 - 0.34 10.7 36.7 0.14 11.9 13.1 3.2 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p Atg14 PF10186.4 CDF89589.1 - 0.35 9.7 32.3 0.13 11.1 8.5 2.1 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 DUF4201 PF13870.1 CDF89589.1 - 0.39 10.1 38.2 1.3 8.4 26.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) NPV_P10 PF05531.7 CDF89589.1 - 0.61 10.3 13.3 7.7 6.8 0.1 3.8 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF3584 PF12128.3 CDF89589.1 - 0.65 7.2 34.2 0.79 6.9 23.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CCDC155 PF14662.1 CDF89589.1 - 0.68 9.5 41.8 0.1 12.1 12.1 2.1 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 DivIC PF04977.10 CDF89589.1 - 0.69 9.4 40.0 0.037 13.5 6.6 4.2 1 1 3 4 4 4 0 Septum formation initiator Rootletin PF15035.1 CDF89589.1 - 0.71 9.8 38.6 0.49 10.3 18.3 2.6 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Spc7 PF08317.6 CDF89589.1 - 0.72 8.4 36.6 0.52 8.9 11.1 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein AAA_27 PF13514.1 CDF89589.1 - 0.73 7.4 30.4 3.2 5.3 21.0 1.8 1 1 0 1 1 1 0 AAA domain DUF972 PF06156.8 CDF89589.1 - 0.87 9.9 33.5 1.5e+04 -6.0 23.3 3.1 1 1 0 1 1 0 0 Protein of unknown function (DUF972) Snapin_Pallidin PF14712.1 CDF89589.1 - 0.91 9.8 23.3 2.8 8.2 7.8 3.2 1 1 2 3 3 3 0 Snapin/Pallidin AAA_13 PF13166.1 CDF89589.1 - 0.98 7.8 33.6 3.4 6.0 23.3 1.7 1 1 0 1 1 1 0 AAA domain Fib_alpha PF08702.5 CDF89589.1 - 1.1 9.4 23.7 0.9 9.6 6.3 2.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DivIVA PF05103.8 CDF89589.1 - 1.1 9.3 35.4 2.1 8.3 9.7 3.0 1 1 1 2 2 2 0 DivIVA protein Lebercilin PF15619.1 CDF89589.1 - 1.3 8.4 41.3 0.47 9.8 15.7 2.2 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF904 PF06005.7 CDF89589.1 - 1.7 9.0 50.8 2.8 8.2 4.9 4.0 2 1 1 3 3 2 0 Protein of unknown function (DUF904) FadA PF09403.5 CDF89589.1 - 1.9 8.4 31.3 6.3 6.8 14.3 2.3 1 1 1 2 2 2 0 Adhesion protein FadA Mnd1 PF03962.10 CDF89589.1 - 2.4 7.8 38.1 5.5 6.6 11.6 2.2 1 1 1 2 2 2 0 Mnd1 family Spc24 PF08286.6 CDF89589.1 - 2.9 7.6 39.2 0.82 9.3 3.7 4.0 1 1 2 3 3 2 0 Spc24 subunit of Ndc80 DUF1664 PF07889.7 CDF89589.1 - 3 7.6 19.5 3.6 7.3 5.3 2.8 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Vps5 PF09325.5 CDF89589.1 - 3.2 6.9 28.1 1.2 8.3 5.9 3.6 1 1 2 3 3 3 0 Vps5 C terminal like TPR_MLP1_2 PF07926.7 CDF89589.1 - 3.4 7.4 45.5 3.1 7.5 15.2 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein IFT57 PF10498.4 CDF89589.1 - 3.6 6.2 31.9 1.1 7.8 16.2 2.1 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 DUF2937 PF11157.3 CDF89589.1 - 4.5 6.5 5.7 1.4 8.1 0.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2937) DUF342 PF03961.8 CDF89589.1 - 4.9 5.4 34.6 2.7 6.3 11.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF342) DUF724 PF05266.9 CDF89589.1 - 5.1 6.6 33.7 1.3 8.5 10.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF3573 PF12097.3 CDF89589.1 - 5.1 5.6 8.5 6.2 5.3 5.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Clr5 PF14420.1 CDF89589.1 - 5.5 6.9 9.0 0.14 12.0 0.6 2.5 3 1 0 3 3 2 0 Clr5 domain DUF745 PF05335.8 CDF89589.1 - 5.5 6.4 21.2 1.6 8.2 5.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Laminin_I PF06008.9 CDF89589.1 - 5.8 6.1 34.3 3.6 6.8 12.6 2.1 1 1 1 2 2 2 0 Laminin Domain I Imm15 PF15590.1 CDF89589.1 - 6 6.0 6.1 10 5.2 0.2 2.8 3 0 0 3 3 2 0 Immunity protein 15 HOOK PF05622.7 CDF89589.1 - 6.1 4.5 34.5 7 4.3 23.9 1.1 1 0 0 1 1 1 0 HOOK protein CENP-K PF11802.3 CDF89589.1 - 6.1 5.9 28.9 0.13 11.4 7.0 2.1 1 1 1 2 2 2 0 Centromere-associated protein K MIS13 PF08202.6 CDF89589.1 - 7.5 5.5 33.5 2.8 6.9 8.5 2.6 1 1 1 2 2 2 0 Mis12-Mtw1 protein family Ax_dynein_light PF10211.4 CDF89589.1 - 7.7 6.3 39.5 6.7 6.4 5.7 3.1 1 1 2 3 3 3 0 Axonemal dynein light chain bZIP_2 PF07716.10 CDF89589.1 - 7.8 6.4 35.8 0.3 10.9 1.7 4.7 2 2 1 4 4 4 0 Basic region leucine zipper Lectin_N PF03954.9 CDF89589.1 - 7.8 5.8 14.8 4.5 6.6 4.5 2.4 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain DUF869 PF05911.6 CDF89589.1 - 7.8 4.5 37.1 3.7 5.6 18.7 2.0 1 1 1 2 2 2 0 Plant protein of unknown function (DUF869) Jnk-SapK_ap_N PF09744.4 CDF89589.1 - 8.9 6.2 38.5 1.7 8.6 19.1 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 T2SM PF04612.7 CDF89589.1 - 9 6.0 16.6 2.4 7.9 2.1 3.2 1 1 2 3 3 3 0 Type II secretion system (T2SS), protein M EOS1 PF12326.3 CDF89590.1 - 1.4e-68 229.2 11.4 1.4e-68 229.2 7.9 1.4 2 0 0 2 2 2 1 N-glycosylation protein MutL_C PF08676.6 CDF89591.1 - 1.9e-25 89.1 0.0 8.9e-25 86.9 0.0 2.1 2 0 0 2 2 2 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.14 CDF89591.1 - 2.8e-23 81.6 0.1 1.4e-22 79.3 0.0 2.1 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.1 CDF89591.1 - 6.1e-14 51.8 0.1 2e-13 50.1 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 CDF89591.1 - 1.7e-10 40.6 0.1 4.3e-10 39.3 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HORMA PF02301.13 CDF89592.1 - 1.5e-21 76.8 1.1 1.9e-21 76.5 0.7 1.1 1 0 0 1 1 1 1 HORMA domain Mito_carr PF00153.22 CDF89593.1 - 1e-63 211.0 1.6 2.5e-21 75.1 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.1 CDF89593.1 - 5.2e-13 48.9 7.5 3.5e-08 33.4 2.0 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.27 CDF89593.1 - 3e-12 44.8 5.5 0.00077 18.5 0.1 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 CDF89593.1 - 6.5e-12 44.2 3.6 0.0045 16.7 0.0 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.1 CDF89593.1 - 3.7e-11 42.4 5.1 1.2e-07 31.2 1.7 3.5 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 CDF89593.1 - 6.4e-09 34.7 2.8 0.0018 17.5 0.0 3.6 3 0 0 3 3 3 3 EF hand SPARC_Ca_bdg PF10591.4 CDF89593.1 - 0.0082 16.1 3.0 0.47 10.5 0.4 2.6 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region MFS_1 PF07690.11 CDF89594.1 - 8.2e-28 97.1 83.0 1.5e-21 76.5 35.5 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Jiraiya PF15038.1 CDF89594.1 - 0.75 9.1 8.4 1 8.7 0.4 2.6 2 0 0 2 2 2 0 Jiraiya 4HBT PF03061.17 CDF89595.1 - 0.00078 19.5 0.4 0.61 10.2 0.1 2.9 3 0 0 3 3 3 2 Thioesterase superfamily Glyco_hydro_101 PF12905.2 CDF89595.1 - 0.021 13.4 0.0 1.5 7.3 0.0 2.1 2 0 0 2 2 2 0 Endo-alpha-N-acetylgalactosaminidase SKG6 PF08693.5 CDF89596.1 - 2e-12 46.2 0.4 2e-12 46.2 0.3 3.0 2 0 0 2 2 2 1 Transmembrane alpha-helix domain He_PIG PF05345.7 CDF89596.1 - 1.5e-09 37.7 3.4 0.0078 16.2 0.5 4.4 3 1 0 3 3 3 2 Putative Ig domain Rifin_STEVOR PF02009.11 CDF89596.1 - 1.5e-05 24.8 0.1 2.4e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Rifin/stevor family MGC-24 PF05283.6 CDF89596.1 - 0.00025 20.8 9.9 0.00072 19.4 6.8 1.8 1 0 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24) TMEM154 PF15102.1 CDF89596.1 - 0.021 14.5 0.8 0.078 12.6 0.0 2.4 2 0 0 2 2 2 0 TMEM154 protein family EF-hand_4 PF12763.2 CDF89597.1 - 2.9e-51 171.5 2.0 3.4e-49 164.8 1.0 2.4 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand End3 PF12761.2 CDF89597.1 - 1.9e-37 128.8 6.4 5.2e-36 124.1 4.4 2.1 1 1 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 IncA PF04156.9 CDF89597.1 - 0.00078 19.0 2.9 0.0014 18.2 2.0 1.5 1 0 0 1 1 1 1 IncA protein DUF4164 PF13747.1 CDF89597.1 - 0.0032 17.5 3.1 0.036 14.2 0.0 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF4164) EF-hand_1 PF00036.27 CDF89597.1 - 0.0045 16.2 1.0 0.03 13.6 1.0 2.2 2 0 0 2 2 2 1 EF hand Prefoldin_2 PF01920.15 CDF89597.1 - 0.0048 16.6 3.0 0.16 11.7 0.3 3.0 3 0 0 3 3 2 1 Prefoldin subunit DivIC PF04977.10 CDF89597.1 - 0.07 12.6 2.8 1.1 8.8 0.0 2.6 2 0 0 2 2 2 0 Septum formation initiator EF-hand_8 PF13833.1 CDF89597.1 - 0.078 12.6 0.8 0.22 11.1 0.6 1.8 1 0 0 1 1 1 0 EF-hand domain pair DUF4140 PF13600.1 CDF89597.1 - 0.097 13.1 6.4 2.2 8.7 0.4 2.5 1 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF724 PF05266.9 CDF89597.1 - 0.12 12.0 5.1 2.5 7.6 1.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF4201 PF13870.1 CDF89597.1 - 0.15 11.5 4.8 0.24 10.8 2.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) EF-hand_6 PF13405.1 CDF89597.1 - 0.16 11.9 0.6 1.6 8.8 0.5 2.5 3 0 0 3 3 2 0 EF-hand domain Baculo_PEP_C PF04513.7 CDF89597.1 - 0.27 11.0 3.8 0.85 9.4 2.6 1.8 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Tropomyosin_1 PF12718.2 CDF89597.1 - 0.47 10.2 5.8 1.8 8.4 0.0 2.6 2 1 0 2 2 2 0 Tropomyosin like CCDC-167 PF15188.1 CDF89597.1 - 0.49 10.3 3.8 5.4 7.0 1.3 2.5 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 Flagellin_N PF00669.15 CDF89597.1 - 0.83 9.4 5.7 0.15 11.8 0.7 1.9 2 0 0 2 2 2 0 Bacterial flagellin N-terminal helical region TPR_MLP1_2 PF07926.7 CDF89597.1 - 0.9 9.2 6.4 6.4 6.5 4.4 2.1 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein FlaC_arch PF05377.6 CDF89597.1 - 1.2 9.0 5.1 2.2 8.2 0.7 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Fib_alpha PF08702.5 CDF89597.1 - 1.9 8.6 7.5 4.3 7.4 1.9 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF972 PF06156.8 CDF89597.1 - 1.9 8.8 4.8 3.1 8.2 0.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF972) Spectrin PF00435.16 CDF89597.1 - 2.5 8.4 5.7 11 6.3 0.5 2.7 2 1 1 3 3 2 0 Spectrin repeat ADIP PF11559.3 CDF89597.1 - 2.8 7.8 8.7 17 5.2 0.2 2.4 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding FlxA PF14282.1 CDF89597.1 - 5.8 6.9 11.3 0.54 10.2 0.1 2.8 3 1 0 3 3 2 0 FlxA-like protein Cep57_CLD_2 PF14197.1 CDF89597.1 - 8.6 6.3 9.4 4.7 7.2 3.1 2.4 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Cpn60_TCP1 PF00118.19 CDF89598.1 - 5.5e-133 444.1 10.4 6.5e-133 443.8 7.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Transposase_23 PF03017.9 CDF89598.1 - 0.066 12.7 0.0 0.21 11.1 0.0 1.8 1 0 0 1 1 1 0 TNP1/EN/SPM transposase DUF3576 PF12100.3 CDF89598.1 - 0.074 13.1 0.0 0.24 11.4 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3576) MKT1_C PF12246.3 CDF89599.1 - 1.1e-65 220.9 3.9 1.8e-65 220.3 2.7 1.3 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.3 CDF89599.1 - 1.1e-28 99.3 0.0 3.4e-28 97.8 0.0 1.9 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.12 CDF89599.1 - 4.8e-21 74.9 0.0 2.1e-20 72.8 0.0 2.1 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.13 CDF89599.1 - 4.4e-08 33.0 0.0 9.1e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 XPG I-region OST3_OST6 PF04756.8 CDF89600.1 - 2.7e-27 95.2 5.4 4.5e-27 94.5 3.8 1.3 1 0 0 1 1 1 1 OST3 / OST6 family DUF1129 PF06570.6 CDF89600.1 - 0.23 10.7 3.7 2 7.6 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1129) DUF4131 PF13567.1 CDF89600.1 - 0.46 9.8 4.4 15 4.9 1.7 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4131) DUF4118 PF13493.1 CDF89600.1 - 3.9 7.7 11.4 3.6 7.8 1.7 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4118) Caps_synth_CapC PF14102.1 CDF89600.1 - 4.2 7.4 9.8 0.54 10.3 3.3 2.1 2 1 0 2 2 2 0 Capsule biosynthesis CapC Snapin_Pallidin PF14712.1 CDF89601.1 - 5.2e-06 26.6 3.8 6.9e-06 26.2 2.6 1.1 1 0 0 1 1 1 1 Snapin/Pallidin YscO PF07321.7 CDF89601.1 - 0.0057 16.4 0.6 0.014 15.2 0.4 1.6 1 1 0 1 1 1 1 Type III secretion protein YscO TMF_TATA_bd PF12325.3 CDF89601.1 - 0.0078 15.9 0.8 0.01 15.5 0.6 1.2 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding Tmemb_cc2 PF10267.4 CDF89601.1 - 0.029 12.9 2.1 0.028 12.9 1.5 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Methyltransf_5 PF01795.14 CDF89601.1 - 0.038 13.2 0.7 0.05 12.8 0.5 1.3 1 1 0 1 1 1 0 MraW methylase family Reo_sigmaC PF04582.7 CDF89601.1 - 0.07 12.3 0.8 0.083 12.0 0.6 1.0 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Laminin_II PF06009.7 CDF89601.1 - 0.072 12.8 1.4 0.12 12.0 1.0 1.6 1 1 0 1 1 1 0 Laminin Domain II DUF1003 PF06210.6 CDF89601.1 - 0.21 11.5 1.4 0.28 11.0 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) DUF4510 PF14971.1 CDF89601.1 - 0.21 11.7 1.0 0.31 11.1 0.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4510) Viral_P18 PF04521.8 CDF89601.1 - 0.37 10.2 2.6 0.33 10.4 0.7 1.6 1 1 1 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein HR1 PF02185.11 CDF89601.1 - 0.75 9.5 6.1 0.88 9.3 3.4 1.8 1 1 1 2 2 2 0 Hr1 repeat C2 PF00168.25 CDF89602.1 - 5.7e-52 173.5 4.7 2.5e-19 68.9 0.1 4.5 4 0 0 4 4 4 4 C2 domain DNA_topoisoIV PF00521.15 CDF89603.1 - 1.9e-118 396.0 0.1 1.9e-118 396.0 0.1 2.4 3 0 0 3 3 3 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseB PF00204.20 CDF89603.1 - 1.7e-30 105.4 3.3 4e-30 104.3 2.3 1.6 1 0 0 1 1 1 1 DNA gyrase B Toprim PF01751.17 CDF89603.1 - 8.8e-12 44.8 0.0 3.8e-11 42.8 0.0 2.1 1 0 0 1 1 1 1 Toprim domain HATPase_c PF02518.21 CDF89603.1 - 9.5e-10 38.1 0.0 4.1e-09 36.1 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ras PF00071.17 CDF89604.1 - 1.4e-49 167.6 0.0 1.6e-49 167.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDF89604.1 - 1.8e-13 51.0 0.0 2.4e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDF89604.1 - 2.6e-08 33.3 0.0 3.5e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.4 CDF89604.1 - 0.00024 20.5 0.0 0.3 10.5 0.0 2.4 2 1 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.22 CDF89604.1 - 0.0073 15.7 0.0 0.062 12.7 0.0 1.9 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_21 PF13304.1 CDF89604.1 - 0.048 13.6 0.0 0.089 12.7 0.0 1.3 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.5 CDF89604.1 - 0.1 11.8 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit NST1 PF13945.1 CDF89605.1 - 4.9e-15 56.0 2.9 4.9e-15 56.0 2.0 6.5 3 2 3 6 6 6 1 Salt tolerance down-regulator DUF106 PF01956.11 CDF89606.1 - 0.077 12.5 0.1 0.077 12.5 0.0 2.3 2 0 0 2 2 2 0 Integral membrane protein DUF106 DUF3488 PF11992.3 CDF89606.1 - 0.095 11.3 5.8 0.47 9.0 1.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3488) Ras PF00071.17 CDF89607.1 - 1.3e-59 200.2 0.0 1.6e-59 199.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDF89607.1 - 1.2e-19 70.9 0.0 2e-19 70.2 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDF89607.1 - 7.9e-18 64.3 0.0 9.7e-18 64.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 CDF89607.1 - 5.5e-08 32.2 0.0 6.9e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 CDF89607.1 - 3.6e-06 26.5 0.0 7e-06 25.5 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CDF89607.1 - 5e-05 23.2 0.0 8.3e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase PP2C PF00481.16 CDF89608.1 - 4.6e-47 160.5 0.0 7.8e-47 159.7 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C zf-CCCH PF00642.19 CDF89609.1 - 0.001 18.7 0.2 0.001 18.7 0.1 2.1 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) PTPS PF01242.14 CDF89609.1 - 0.061 13.0 0.9 11 5.6 0.2 2.6 2 1 0 2 2 2 0 6-pyruvoyl tetrahydropterin synthase zf-CCCH_2 PF14608.1 CDF89609.1 - 7.9 6.6 15.4 1.5 8.9 1.5 2.8 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type DUF2183 PF09949.4 CDF89610.1 - 9.6e-31 105.6 0.0 2.5e-30 104.3 0.0 1.8 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) Rep_1 PF01446.12 CDF89610.1 - 0.079 12.2 0.1 0.17 11.1 0.1 1.5 1 0 0 1 1 1 0 Replication protein tRNA-synt_2d PF01409.15 CDF89611.1 - 1.3e-47 162.1 0.2 1.3e-25 90.0 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.9 CDF89611.1 - 3.4e-26 91.2 0.2 1.6e-25 89.0 0.0 2.2 2 0 0 2 2 2 1 Ferredoxin-fold anticodon binding domain DUF3811 PF11656.3 CDF89611.1 - 0.0079 16.2 0.2 0.023 14.7 0.2 1.8 1 0 0 1 1 1 1 YjbD family (DUF3811) PAS_10 PF13596.1 CDF89611.1 - 0.014 15.6 0.1 0.04 14.1 0.1 1.8 1 0 0 1 1 1 0 PAS domain tRNA-synt_2 PF00152.15 CDF89611.1 - 1 8.0 5.5 1.5 7.5 0.0 2.9 4 0 0 4 4 4 0 tRNA synthetases class II (D, K and N) ATG11 PF10377.4 CDF89612.1 - 2.2e-38 131.0 0.9 2.2e-38 131.0 0.6 2.6 2 0 0 2 2 2 1 Autophagy-related protein 11 DUF1515 PF07439.6 CDF89612.1 - 0.023 14.5 2.3 0.7 9.7 0.1 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) Acetyltransf_1 PF00583.19 CDF89613.1 - 3.3e-18 65.5 0.0 4.7e-18 64.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 CDF89613.1 - 4.7e-10 39.0 0.1 7.1e-10 38.5 0.1 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.1 CDF89613.1 - 5.6e-09 36.0 0.0 7.8e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 CDF89613.1 - 1e-08 35.1 0.0 1.5e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CDF89613.1 - 1.1e-07 31.9 0.0 1.4e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 CDF89613.1 - 8.2e-06 25.6 0.0 2.1e-05 24.3 0.0 1.7 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 CDF89613.1 - 2.8e-05 24.3 0.0 3.3e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 CDF89613.1 - 0.0012 18.7 0.0 0.0026 17.6 0.0 1.6 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase PCNA_N PF00705.13 CDF89614.1 - 1.3e-50 170.1 1.6 1.3e-50 170.1 1.1 1.5 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.10 CDF89614.1 - 2.8e-50 169.5 0.0 8.3e-50 167.9 0.0 1.7 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.11 CDF89614.1 - 9.3e-07 27.8 0.2 3.9e-05 22.5 0.1 2.1 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.8 CDF89614.1 - 0.00095 18.3 0.0 0.0011 18.1 0.0 1.2 1 0 0 1 1 1 1 Rad9 FOP_dimer PF09398.5 CDF89614.1 - 0.1 12.5 0.2 0.24 11.4 0.1 1.6 1 0 0 1 1 1 0 FOP N terminal dimerisation domain HMG_box PF00505.14 CDF89615.1 - 3.3e-25 88.1 0.7 4.8e-25 87.6 0.5 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 CDF89615.1 - 2.3e-18 66.2 0.9 3.2e-18 65.8 0.6 1.2 1 0 0 1 1 1 1 HMG-box domain HMG_box_5 PF14887.1 CDF89615.1 - 0.0019 17.9 1.1 0.0026 17.4 0.1 1.6 2 0 0 2 2 2 1 HMG (high mobility group) box 5 DUF1014 PF06244.7 CDF89615.1 - 0.012 15.7 0.1 0.05 13.8 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1014) CHDNT PF08073.7 CDF89615.1 - 0.059 13.0 0.0 0.089 12.4 0.0 1.2 1 0 0 1 1 1 0 CHDNT (NUC034) domain YABBY PF04690.8 CDF89615.1 - 0.092 12.9 0.7 0.11 12.6 0.3 1.4 1 1 0 1 1 1 0 YABBY protein zf-Tim10_DDP PF02953.10 CDF89616.1 - 1.9e-16 59.1 0.4 2.4e-16 58.7 0.3 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger TTL PF03133.10 CDF89617.1 - 2.6e-78 262.9 0.6 3.6e-78 262.4 0.4 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family SurE PF01975.12 CDF89617.1 - 2.1e-37 128.3 0.0 3.5e-37 127.6 0.0 1.3 1 0 0 1 1 1 1 Survival protein SurE ATP-grasp_4 PF13535.1 CDF89617.1 - 0.0025 17.5 0.0 0.016 14.9 0.0 2.3 2 1 1 3 3 3 1 ATP-grasp domain ATPgrasp_YheCD PF14398.1 CDF89617.1 - 0.0029 16.4 0.0 0.08 11.7 0.0 2.2 2 0 0 2 2 2 1 YheC/D like ATP-grasp ATPgrasp_Ter PF15632.1 CDF89617.1 - 0.11 11.2 0.0 0.42 9.3 0.0 1.8 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon RXT2_N PF08595.6 CDF89618.1 - 2.2e-41 141.1 1.7 2.2e-41 141.1 1.2 2.0 2 0 0 2 2 2 1 RXT2-like, N-terminal 4HBT_2 PF13279.1 CDF89619.1 - 3.6e-10 40.3 0.0 5.1e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily Pkinase PF00069.20 CDF89620.1 - 1.1e-63 214.8 0.1 1.7e-63 214.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF89620.1 - 1.2e-30 106.4 0.0 1.7e-30 105.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Seadorna_VP7 PF07387.6 CDF89620.1 - 0.074 11.8 0.1 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase PF00069.20 CDF89621.1 - 1.7e-26 92.9 0.0 5.2e-26 91.3 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain HEAT PF02985.17 CDF89621.1 - 8.3e-15 53.4 4.3 0.0097 15.9 0.0 6.7 6 0 0 6 6 6 3 HEAT repeat Pkinase_Tyr PF07714.12 CDF89621.1 - 3.6e-12 45.9 0.0 1.4e-11 43.9 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase HEAT_2 PF13646.1 CDF89621.1 - 6.6e-09 35.9 0.0 0.00062 20.0 0.0 3.5 2 1 1 3 3 3 3 HEAT repeats WD40 PF00400.27 CDF89621.1 - 0.0055 16.5 0.5 2.3 8.2 0.0 3.4 3 0 0 3 3 3 1 WD domain, G-beta repeat RasGEF_N_2 PF14663.1 CDF89621.1 - 0.012 15.5 0.1 0.19 11.7 0.0 2.8 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Vac14_Fab1_bd PF12755.2 CDF89621.1 - 0.013 15.8 3.8 3.3 8.1 0.3 3.4 2 1 2 4 4 4 0 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.1 CDF89621.1 - 0.026 15.0 0.1 21 5.7 0.0 3.4 2 1 1 3 3 3 0 HEAT-like repeat Kelch_6 PF13964.1 CDF89621.1 - 0.19 11.9 1.7 9.2 6.6 0.0 3.6 4 0 0 4 4 4 0 Kelch motif Sec8_exocyst PF04048.9 CDF89622.1 - 8.7e-44 148.5 7.8 2.1e-43 147.3 4.9 2.1 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain Sec5 PF15469.1 CDF89622.1 - 0.0049 16.6 3.4 0.0049 16.6 2.3 2.8 3 1 0 3 3 3 1 Exocyst complex component Sec5 Med15_fungi PF05397.7 CDF89622.1 - 0.15 12.0 3.4 1.2 9.1 0.0 4.0 4 0 0 4 4 4 0 Mediator complex subunit 15 Fes1 PF08609.5 CDF89624.1 - 6.9e-29 100.1 4.2 5.2e-28 97.3 0.3 3.2 3 1 1 4 4 4 1 Nucleotide exchange factor Fes1 HEAT_2 PF13646.1 CDF89624.1 - 0.00021 21.4 0.0 0.0053 17.0 0.0 2.5 1 1 1 2 2 2 1 HEAT repeats HEAT PF02985.17 CDF89624.1 - 0.001 18.9 0.4 0.94 9.7 0.0 3.4 3 0 0 3 3 3 1 HEAT repeat Arm PF00514.18 CDF89624.1 - 0.0024 17.6 0.6 1.1 9.1 0.0 3.5 3 1 1 4 4 4 1 Armadillo/beta-catenin-like repeat DUF908 PF06012.7 CDF89624.1 - 0.0084 15.4 0.2 0.028 13.7 0.0 1.9 2 1 0 2 2 2 1 Domain of Unknown Function (DUF908) V-ATPase_H_C PF11698.3 CDF89624.1 - 0.0086 15.9 1.2 1.4 8.8 0.0 3.0 1 1 1 3 3 3 1 V-ATPase subunit H Vac14_Fig4_bd PF11916.3 CDF89624.1 - 0.01 14.9 1.7 0.023 13.8 1.2 1.5 1 0 0 1 1 1 0 Vacuolar protein 14 C-terminal Fig4p binding HEAT_EZ PF13513.1 CDF89624.1 - 0.09 13.2 0.0 0.5 10.9 0.0 2.4 1 1 0 1 1 1 0 HEAT-like repeat UPF0253 PF06786.7 CDF89624.1 - 0.13 12.4 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0253) Vps51 PF08700.6 CDF89625.1 - 3.8e-10 39.4 3.0 5.7e-10 38.8 0.3 2.6 2 1 0 2 2 2 1 Vps51/Vps67 COG2 PF06148.6 CDF89625.1 - 0.0024 17.7 7.5 0.15 11.9 0.9 2.7 2 0 0 2 2 2 2 COG (conserved oligomeric Golgi) complex component, COG2 DUF4093 PF13331.1 CDF89625.1 - 0.035 14.3 2.7 18 5.6 0.1 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4093) NPV_P10 PF05531.7 CDF89625.1 - 0.57 10.4 5.8 1.6 9.0 0.5 2.8 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein WD40 PF00400.27 CDF89626.1 - 1.4e-25 88.1 13.5 2.5e-06 27.1 0.0 7.1 8 0 0 8 8 8 4 WD domain, G-beta repeat eIF2A PF08662.6 CDF89626.1 - 7.6e-07 29.0 2.1 0.0007 19.3 0.5 4.6 3 1 1 4 4 4 1 Eukaryotic translation initiation factor eIF2A LisH PF08513.6 CDF89626.1 - 9.9e-05 21.9 0.1 0.00018 21.1 0.0 1.5 1 0 0 1 1 1 1 LisH Nup160 PF11715.3 CDF89626.1 - 0.0011 17.1 0.3 0.32 9.0 0.0 3.0 3 0 0 3 3 3 2 Nucleoporin Nup120/160 Pyocin_S PF06958.7 CDF89626.1 - 0.11 12.8 0.0 0.62 10.4 0.0 2.0 2 0 0 2 2 2 0 S-type Pyocin Tfb4 PF03850.9 CDF89627.1 - 1e-105 352.9 0.2 1.2e-105 352.7 0.2 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 VWA_2 PF13519.1 CDF89627.1 - 0.0013 18.8 0.1 0.0025 17.9 0.0 1.5 1 1 0 1 1 1 1 von Willebrand factor type A domain AAA_25 PF13481.1 CDF89627.1 - 0.045 13.1 0.0 0.088 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain SIP1 PF04938.7 CDF89628.1 - 0.002 17.5 0.1 0.038 13.3 0.0 2.4 2 1 0 2 2 2 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) RasGAP PF00616.14 CDF89628.1 - 0.022 14.4 0.0 0.032 13.9 0.0 1.3 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase CARDB PF07705.6 CDF89628.1 - 0.026 14.5 0.0 0.05 13.6 0.0 1.5 1 0 0 1 1 1 0 CARDB Mito_carr PF00153.22 CDF89629.1 - 1.8e-57 191.0 1.2 4.6e-20 71.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein CM_2 PF01817.16 CDF89630.1 - 1.2e-08 34.9 0.0 1.9e-05 24.6 0.0 3.4 2 1 0 2 2 2 2 Chorismate mutase type II DnaJ PF00226.26 CDF89631.1 - 7.8e-15 54.3 0.4 1.3e-14 53.6 0.3 1.4 1 0 0 1 1 1 1 DnaJ domain UPF0139 PF03669.8 CDF89632.1 - 0.00035 20.0 1.8 0.00078 18.9 1.2 1.7 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0139) Vac_ImportDeg PF09783.4 CDF89633.1 - 8e-68 227.3 0.1 1.2e-67 226.7 0.0 1.3 1 0 0 1 1 1 1 Vacuolar import and degradation protein ENTH PF01417.15 CDF89633.1 - 0.0055 16.5 0.1 0.011 15.6 0.1 1.4 1 0 0 1 1 1 1 ENTH domain HMG_box PF00505.14 CDF89634.1 - 9.7e-17 61.0 0.2 1.7e-16 60.2 0.2 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.5 CDF89634.1 - 4.3e-06 27.0 0.1 7e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 HMG-box domain Pho88 PF10032.4 CDF89636.1 - 3.5e-74 248.1 0.1 4e-74 248.0 0.0 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) ThiF PF00899.16 CDF89637.1 - 1.2e-31 109.3 0.5 2.4e-31 108.3 0.1 1.7 2 1 0 2 2 2 1 ThiF family UBACT PF02134.16 CDF89637.1 - 2.7e-15 55.6 0.0 1.1e-14 53.7 0.0 2.0 2 0 0 2 2 2 1 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 CDF89637.1 - 3.1e-08 32.8 1.2 1e-07 31.2 0.9 1.9 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.15 CDF89637.1 - 0.00043 20.3 0.3 0.0019 18.3 0.1 2.3 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase DUF773 PF05600.7 CDF89637.1 - 0.043 12.6 0.0 0.052 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF773) Fe-S_biosyn PF01521.15 CDF89638.1 - 9.8e-11 41.5 0.1 1.2e-06 28.4 0.1 2.2 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis DPBB_1 PF03330.13 CDF89638.1 - 0.0061 16.5 0.1 0.16 11.9 0.0 2.4 2 0 0 2 2 2 1 Rare lipoprotein A (RlpA)-like double-psi beta-barrel Mgr1 PF08602.5 CDF89638.1 - 0.089 11.7 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit CENP-L PF13092.1 CDF89639.1 - 0.043 13.5 0.1 0.19 11.5 0.1 2.0 1 1 1 2 2 2 0 Kinetochore complex Sim4 subunit Fta1 EF-hand_1 PF00036.27 CDF89641.1 - 5.9e-30 100.2 4.6 1.7e-08 33.1 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.1 CDF89641.1 - 4.5e-27 93.9 0.8 1.9e-13 50.3 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.1 CDF89641.1 - 5.9e-25 84.8 3.2 6.3e-08 31.8 0.0 4.3 4 1 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.1 CDF89641.1 - 6.8e-19 67.2 5.3 2e-07 30.4 0.0 4.2 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.1 CDF89641.1 - 6e-17 60.1 3.8 1.9e-07 30.1 0.0 4.3 4 0 0 4 4 4 2 EF hand EF-hand_9 PF14658.1 CDF89641.1 - 2.5e-12 46.5 0.0 4e-08 33.0 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.4 CDF89641.1 - 3.7e-06 26.9 0.2 0.0012 18.8 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.8 CDF89641.1 - 1.5e-05 24.4 0.0 0.14 11.7 0.0 2.7 2 1 0 3 3 3 2 Uncharacterised protein family (UPF0154) Caleosin PF05042.8 CDF89641.1 - 0.00036 20.1 0.0 0.24 10.9 0.0 2.2 2 0 0 2 2 2 2 Caleosin related protein EF-hand_4 PF12763.2 CDF89641.1 - 0.0013 18.4 0.3 0.004 16.8 0.1 1.8 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand DUF853 PF05872.7 CDF89641.1 - 0.0037 15.6 0.3 0.098 10.9 0.0 2.0 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF853) p25-alpha PF05517.7 CDF89641.1 - 0.019 15.2 0.0 0.57 10.4 0.0 2.1 1 1 1 2 2 2 0 p25-alpha TerB PF05099.8 CDF89641.1 - 0.026 14.2 0.1 0.72 9.5 0.0 2.2 2 1 0 2 2 2 0 Tellurite resistance protein TerB DUF4373 PF14297.1 CDF89641.1 - 0.14 12.4 0.1 2.3 8.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4373) RNA_pol_Rpb4 PF03874.11 CDF89641.1 - 0.15 12.0 0.8 1 9.3 0.0 2.3 2 1 0 2 2 2 0 RNA polymerase Rpb4 Glyco_trans_1_4 PF13692.1 CDF89642.1 - 6.1e-14 52.3 0.0 1.8e-13 50.7 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.15 CDF89642.1 - 2.7e-07 30.1 0.0 4e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.1 CDF89642.1 - 0.00039 20.6 0.0 0.00064 19.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Hist_deacetyl PF00850.14 CDF89643.1 - 1.3e-71 241.4 0.0 1.6e-71 241.1 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Spermine_synth PF01564.12 CDF89644.1 - 1.7e-99 331.7 0.0 2e-99 331.4 0.0 1.0 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_31 PF13847.1 CDF89644.1 - 0.00012 21.7 0.0 0.00018 21.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CDF89644.1 - 0.0004 20.4 0.0 0.00067 19.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDF89644.1 - 0.0013 19.2 0.0 0.0023 18.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDF89644.1 - 0.003 17.9 0.0 0.012 16.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDF89644.1 - 0.023 14.3 0.0 0.055 13.1 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain DUF226 PF02890.9 CDF89644.1 - 0.024 14.3 0.1 0.054 13.2 0.0 1.5 1 0 0 1 1 1 0 Borrelia family of unknown function DUF226 Methyltransf_30 PF05430.6 CDF89644.1 - 0.033 13.8 0.0 0.067 12.8 0.0 1.5 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase RNase_H2-Ydr279 PF09468.5 CDF89644.1 - 0.053 12.7 0.1 0.08 12.1 0.1 1.3 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Methyltransf_2 PF00891.13 CDF89644.1 - 0.12 11.5 0.0 0.62 9.2 0.0 2.0 1 1 1 2 2 2 0 O-methyltransferase Med1 PF10744.4 CDF89645.1 - 2.3e-69 234.0 9.8 1.3e-66 225.0 6.8 2.2 1 1 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 NUDIX PF00293.23 CDF89646.1 - 4.2e-17 62.0 0.0 8e-17 61.1 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain TPR_11 PF13414.1 CDF89647.1 - 2.9e-52 174.2 37.8 2.9e-11 42.8 0.3 6.9 2 2 6 8 8 8 8 TPR repeat TPR_1 PF00515.23 CDF89647.1 - 4e-50 165.4 20.8 1.7e-07 30.5 0.0 10.9 10 1 0 10 10 10 8 Tetratricopeptide repeat TPR_2 PF07719.12 CDF89647.1 - 1.4e-42 140.1 25.7 8.9e-05 22.1 0.0 10.9 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_17 PF13431.1 CDF89647.1 - 2.7e-29 98.9 23.4 0.00044 20.2 0.0 11.4 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_12 PF13424.1 CDF89647.1 - 1.8e-28 98.2 31.0 6.8e-08 32.3 0.2 8.2 2 2 6 8 8 8 8 Tetratricopeptide repeat TPR_8 PF13181.1 CDF89647.1 - 1.5e-26 90.1 14.5 0.049 13.4 0.1 9.8 8 1 1 9 9 9 9 Tetratricopeptide repeat TPR_16 PF13432.1 CDF89647.1 - 1.7e-21 76.3 57.2 5.1e-06 27.0 0.7 8.0 6 2 2 8 8 7 7 Tetratricopeptide repeat TPR_7 PF13176.1 CDF89647.1 - 3.5e-19 67.0 26.1 0.00013 21.5 0.1 9.7 11 0 0 11 11 9 5 Tetratricopeptide repeat TPR_14 PF13428.1 CDF89647.1 - 3.8e-18 64.3 55.8 0.00035 20.9 0.1 11.9 3 3 8 11 11 10 9 Tetratricopeptide repeat TPR_19 PF14559.1 CDF89647.1 - 3.2e-12 46.5 47.9 3.2e-05 24.1 0.4 8.2 5 3 2 7 7 6 5 Tetratricopeptide repeat TPR_9 PF13371.1 CDF89647.1 - 2.9e-08 33.4 8.9 6.2e-05 22.7 0.0 7.0 5 1 3 8 8 6 5 Tetratricopeptide repeat TPR_6 PF13174.1 CDF89647.1 - 1.1e-07 31.8 40.8 1.2 9.7 0.0 11.0 10 1 0 10 10 9 3 Tetratricopeptide repeat ChAPs PF09295.5 CDF89647.1 - 0.0064 15.3 5.0 0.21 10.2 1.2 3.1 3 0 0 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_15 PF13429.1 CDF89647.1 - 0.012 14.7 0.1 0.012 14.7 0.0 5.7 2 1 3 5 5 4 0 Tetratricopeptide repeat TPR_10 PF13374.1 CDF89647.1 - 0.18 11.7 26.4 0.77 9.7 0.4 8.1 8 0 0 8 8 8 0 Tetratricopeptide repeat SNF2_N PF00176.18 CDF89648.1 - 4.6e-75 252.2 0.1 6.4e-75 251.7 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CDF89648.1 - 5.4e-11 42.1 0.0 1.3e-10 40.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDF89648.1 - 3.8e-09 36.6 0.0 1.1e-08 35.1 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.20 CDF89648.1 - 4e-08 32.7 10.7 4e-08 32.7 7.4 2.4 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.24 CDF89648.1 - 1e-07 31.6 0.0 2.2e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-RING_2 PF13639.1 CDF89648.1 - 2.1e-05 24.2 9.6 2.1e-05 24.2 6.7 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 CDF89648.1 - 2.9e-05 23.9 9.4 2.9e-05 23.9 6.5 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CDF89648.1 - 0.0003 20.6 9.2 0.0003 20.6 6.4 2.1 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.1 CDF89648.1 - 0.004 16.8 8.0 0.004 16.8 5.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDF89648.1 - 0.0078 15.9 9.8 0.0078 15.9 6.8 2.4 2 0 0 2 2 2 1 zinc-RING finger domain Zn_Tnp_IS91 PF14319.1 CDF89648.1 - 0.1 12.1 14.2 0.087 12.3 2.4 2.9 3 0 0 3 3 3 0 Transposase zinc-binding domain Auto_anti-p27 PF06677.7 CDF89648.1 - 0.11 12.2 2.4 1.5 8.6 0.2 2.7 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) NAD_binding_4 PF07993.7 CDF89649.1 - 3.7e-72 242.2 0.0 5.3e-72 241.7 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.23 CDF89649.1 - 2.3e-71 240.3 0.0 3e-71 240.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.20 CDF89649.1 - 1.7e-16 60.1 0.0 4.2e-16 58.9 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.16 CDF89649.1 - 2.1e-13 50.2 0.0 3.4e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.1 CDF89649.1 - 3.6e-08 34.2 0.1 5e-07 30.5 0.0 2.6 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain 3Beta_HSD PF01073.14 CDF89649.1 - 1.2e-05 24.1 0.0 2.6e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 CDF89649.1 - 0.094 11.5 0.0 0.47 9.2 0.0 2.0 2 0 0 2 2 2 0 RmlD substrate binding domain Not3 PF04065.10 CDF89650.1 - 1.6e-78 263.2 34.6 4e-76 255.3 24.0 2.5 1 1 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.13 CDF89650.1 - 1.2e-27 96.3 14.9 1.6e-25 89.5 4.3 3.3 3 1 1 4 4 4 2 NOT2 / NOT3 / NOT5 family DrsE_2 PF13686.1 CDF89650.1 - 0.12 12.1 0.0 0.29 10.8 0.0 1.6 1 0 0 1 1 1 0 DsrE/DsrF/DrsH-like family AKNA PF12443.3 CDF89650.1 - 2.7 8.0 17.2 1.3 9.0 1.1 2.9 1 1 1 2 2 2 0 AT-hook-containing transcription factor LMWPc PF01451.16 CDF89651.1 - 5.1e-40 137.0 0.0 5.7e-40 136.8 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Transketolase_N PF00456.16 CDF89652.1 - 1.2e-135 451.5 0.0 1.8e-135 451.0 0.0 1.3 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.19 CDF89652.1 - 2.6e-46 157.3 0.0 1.3e-45 155.0 0.0 1.9 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 CDF89652.1 - 7.9e-12 45.1 0.0 1.8e-11 44.0 0.0 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain E1_dh PF00676.15 CDF89652.1 - 5.3e-05 22.0 0.0 0.0002 20.1 0.0 1.8 2 0 0 2 2 2 1 Dehydrogenase E1 component DUF498 PF04430.9 CDF89652.1 - 0.0022 17.5 0.0 0.0067 15.9 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) DXP_synthase_N PF13292.1 CDF89652.1 - 0.028 13.3 0.2 0.053 12.4 0.1 1.5 1 1 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase DUF3939 PF13075.1 CDF89652.1 - 0.096 12.4 0.0 2.7 7.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3939) Opy2 PF09463.5 CDF89653.1 - 1e-10 41.4 21.5 1.5e-10 40.9 14.9 1.3 1 0 0 1 1 1 1 Opy2 protein Colicin_V PF02674.11 CDF89653.1 - 0.025 14.4 0.0 0.035 13.9 0.0 1.1 1 0 0 1 1 1 0 Colicin V production protein FAM176 PF14851.1 CDF89653.1 - 0.52 9.9 0.0 0.52 9.9 0.0 2.6 3 0 0 3 3 3 0 FAM176 family RXT2_N PF08595.6 CDF89653.1 - 5.3 6.8 9.4 1.3 8.8 1.0 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF3074 PF11274.3 CDF89654.1 - 2.4e-28 98.9 0.4 3.4e-28 98.5 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) CIMR PF00878.13 CDF89657.1 - 1.8e-11 44.0 1.2 2.9e-05 23.8 0.1 2.6 2 1 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat PRKCSH_1 PF13015.1 CDF89657.1 - 2.6e-05 23.7 0.0 4.6e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein Man-6-P_recep PF02157.10 CDF89657.1 - 0.014 14.4 0.0 0.021 13.8 0.0 1.2 1 0 0 1 1 1 0 Mannose-6-phosphate receptor LAMTOR PF15454.1 CDF89657.1 - 0.26 11.5 2.9 0.35 11.1 0.9 2.1 2 0 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator GTP_EFTU PF00009.22 CDF89658.1 - 2.7e-56 190.0 0.0 3.8e-56 189.5 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 CDF89658.1 - 3.6e-36 123.2 0.0 9.9e-36 121.8 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 CDF89658.1 - 5.4e-16 58.4 2.2 1.6e-15 56.9 1.5 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 CDF89658.1 - 0.0014 18.2 0.5 0.0014 18.2 0.3 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 CDF89658.1 - 0.0096 15.8 0.4 0.033 14.1 0.3 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase RRM_1 PF00076.17 CDF89659.1 - 2.8e-09 36.4 0.0 5.1e-06 26.0 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF89659.1 - 2.1e-08 34.0 0.1 0.002 18.0 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF89659.1 - 3.7e-06 26.6 0.1 0.0085 15.9 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CD4-extracel PF09191.5 CDF89659.1 - 0.05 13.6 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 CD4, extracellular Pex14_N PF04695.8 CDF89659.1 - 0.44 10.5 3.9 0.24 11.4 1.0 1.9 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF328 PF03883.9 CDF89660.1 - 0.088 12.0 1.2 0.83 8.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF328) tRNA-synt_2b PF00587.20 CDF89661.1 - 5.7e-69 231.1 0.1 1e-68 230.2 0.1 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 CDF89661.1 - 3.5e-20 71.7 0.0 1.1e-19 70.1 0.0 1.9 1 0 0 1 1 1 1 Anticodon binding domain DIM1 PF02966.11 CDF89662.1 - 4.5e-69 230.0 1.2 5.1e-69 229.9 0.8 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.15 CDF89662.1 - 0.0077 15.9 0.1 0.01 15.4 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Ribosomal_L31 PF01197.13 CDF89663.1 - 0.0011 18.9 0.0 0.002 18.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L31 Me-amine-dh_H PF06433.6 CDF89663.1 - 0.033 12.8 0.1 0.047 12.3 0.0 1.2 1 0 0 1 1 1 0 Methylamine dehydrogenase heavy chain (MADH) Tau95 PF09734.4 CDF89664.1 - 3.3e-61 207.3 0.3 4.7e-61 206.8 0.2 1.2 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit BTV_NS2 PF04514.7 CDF89664.1 - 0.31 9.8 10.9 0.47 9.2 7.6 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 PP2C PF00481.16 CDF89665.1 - 1.1e-60 205.2 0.0 1.2e-56 191.9 0.0 2.1 1 1 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.7 CDF89665.1 - 0.0046 16.6 0.0 0.49 10.0 0.0 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.1 CDF89665.1 - 0.0048 16.3 0.0 0.016 14.6 0.0 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C Glyco_transf_20 PF00982.16 CDF89666.1 - 1.2e-199 663.7 0.0 1.3e-199 663.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glycos_transf_1 PF00534.15 CDF89666.1 - 0.0033 16.8 2.8 0.045 13.1 0.2 3.1 3 1 0 3 3 3 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.6 CDF89666.1 - 0.09 12.2 0.5 0.18 11.2 0.1 1.6 2 0 0 2 2 2 0 Starch synthase catalytic domain ATP-synt_ab PF00006.20 CDF89668.1 - 2e-61 207.2 0.0 2.8e-61 206.7 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 CDF89668.1 - 4.3e-17 62.5 0.3 8.5e-17 61.6 0.2 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 CDF89668.1 - 5.9e-13 48.8 0.9 1.2e-12 47.8 0.6 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.5 CDF89668.1 - 0.00064 19.5 0.4 0.0022 17.8 0.3 1.9 1 0 0 1 1 1 1 HAS barrel domain Atg14 PF10186.4 CDF89669.1 - 6.3e-50 169.8 1.0 7.5e-50 169.5 0.7 1.1 1 0 0 1 1 1 1 UV radiation resistance protein and autophagy-related subunit 14 DUF3086 PF11285.3 CDF89669.1 - 0.073 11.8 0.8 0.16 10.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3086) Dynamin_N PF00350.18 CDF89670.1 - 0.003 17.4 0.1 0.37 10.5 0.1 2.2 2 0 0 2 2 2 2 Dynamin family MMR_HSR1 PF01926.18 CDF89670.1 - 0.005 16.7 0.0 0.66 9.9 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF1975 PF09318.5 CDF89670.1 - 0.026 14.1 0.9 0.048 13.2 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1975) Miro PF08477.8 CDF89670.1 - 0.027 14.9 0.0 0.16 12.4 0.0 2.4 3 0 0 3 3 3 0 Miro-like protein Ras PF00071.17 CDF89670.1 - 0.14 11.5 0.0 1.9 7.8 0.0 2.4 2 0 0 2 2 2 0 Ras family BtpA PF03437.10 CDF89671.1 - 0.12 11.6 0.0 0.24 10.6 0.0 1.4 1 0 0 1 1 1 0 BtpA family PH_11 PF15413.1 CDF89672.1 - 0.0047 17.1 2.4 0.25 11.6 0.1 3.0 2 1 1 3 3 3 2 Pleckstrin homology domain PH PF00169.24 CDF89672.1 - 0.02 15.0 4.6 0.056 13.6 1.5 2.9 2 2 0 2 2 2 0 PH domain HAP1_N PF04849.8 CDF89673.1 - 0.00095 18.1 17.5 0.0017 17.4 12.1 1.3 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Filament PF00038.16 CDF89673.1 - 0.0097 15.4 20.7 0.019 14.4 14.3 1.4 1 0 0 1 1 1 1 Intermediate filament protein TMF_DNA_bd PF12329.3 CDF89673.1 - 2.3 8.0 23.1 0.093 12.5 1.3 3.1 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF3450 PF11932.3 CDF89673.1 - 3.8 6.6 20.8 2.9 7.0 3.1 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) DUF724 PF05266.9 CDF89673.1 - 6.3 6.3 19.2 0.7 9.4 8.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) SRP54 PF00448.17 CDF89674.1 - 3e-78 261.7 2.5 1.6e-77 259.4 0.5 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.14 CDF89674.1 - 1e-25 89.9 11.4 1e-25 89.9 7.9 4.1 3 1 1 4 4 3 1 Signal peptide binding domain SRP54_N PF02881.14 CDF89674.1 - 1.6e-14 53.7 3.3 4.7e-14 52.2 2.3 1.9 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.14 CDF89674.1 - 2.3e-07 30.4 1.0 2.3e-06 27.2 0.2 2.7 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.9 CDF89674.1 - 2.7e-05 23.9 0.2 7.9e-05 22.3 0.0 1.9 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B CbiA PF01656.18 CDF89674.1 - 2.9e-05 23.5 0.7 0.00013 21.4 0.1 2.4 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 CDF89674.1 - 2.9e-05 24.0 0.0 0.032 14.1 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.1 CDF89674.1 - 3.7e-05 23.6 0.0 0.00011 22.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain SRPRB PF09439.5 CDF89674.1 - 0.00067 18.9 4.8 1.2 8.3 0.0 4.0 4 0 0 4 4 4 2 Signal recognition particle receptor beta subunit AAA_17 PF13207.1 CDF89674.1 - 0.00086 20.1 0.0 0.0018 19.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain ArgK PF03308.11 CDF89674.1 - 0.0054 15.5 0.1 0.021 13.6 0.0 2.1 1 1 1 2 2 2 1 ArgK protein VirE PF05272.6 CDF89674.1 - 0.0092 15.4 0.1 0.026 14.0 0.0 1.8 2 0 0 2 2 2 1 Virulence-associated protein E AAA_22 PF13401.1 CDF89674.1 - 0.01 15.9 0.2 0.068 13.3 0.1 2.6 1 1 0 1 1 1 0 AAA domain AAA PF00004.24 CDF89674.1 - 0.012 15.7 2.7 0.077 13.1 0.3 3.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 CDF89674.1 - 0.015 14.7 0.1 0.035 13.5 0.1 1.6 1 1 0 1 1 1 0 AAA-like domain AAA_18 PF13238.1 CDF89674.1 - 0.016 15.5 0.0 0.055 13.7 0.0 2.0 1 1 0 1 1 1 0 AAA domain APS_kinase PF01583.15 CDF89674.1 - 0.027 14.1 0.0 0.06 13.0 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase MipZ PF09140.6 CDF89674.1 - 0.043 12.9 0.1 1.2 8.1 0.1 2.7 1 1 0 1 1 1 0 ATPase MipZ AAA_16 PF13191.1 CDF89674.1 - 0.051 13.5 0.0 0.1 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain ArsA_ATPase PF02374.10 CDF89674.1 - 6.8 5.6 14.5 0.38 9.7 0.1 3.3 3 1 0 4 4 4 0 Anion-transporting ATPase DUF1712 PF08217.6 CDF89675.1 - 3.7e-146 487.8 0.0 1.2e-126 423.4 0.0 2.0 1 1 1 2 2 2 2 Fungal domain of unknown function (DUF1712) AA_permease PF00324.16 CDF89676.1 - 4.8e-119 397.8 23.0 5.5e-119 397.6 16.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CDF89676.1 - 6.6e-26 90.8 26.7 8.2e-26 90.5 18.5 1.0 1 0 0 1 1 1 1 Amino acid permease DUF1772 PF08592.6 CDF89676.1 - 0.0055 16.4 8.8 0.32 10.7 0.1 4.3 4 0 0 4 4 4 1 Domain of unknown function (DUF1772) DIL PF01843.14 CDF89677.1 - 3.8e-11 42.7 7.7 3.2e-06 26.9 0.2 3.0 3 0 0 3 3 3 2 DIL domain Ank_5 PF13857.1 CDF89677.1 - 6.4e-07 29.4 0.1 0.048 13.9 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 CDF89677.1 - 0.004 17.4 0.0 0.0094 16.2 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) DUF4423 PF14394.1 CDF89677.1 - 0.026 14.0 0.5 0.063 12.8 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) Ank PF00023.25 CDF89677.1 - 0.35 10.7 1.4 4 7.4 0.2 2.9 3 0 0 3 3 3 0 Ankyrin repeat PRMT5 PF05185.11 CDF89678.1 - 5.1e-144 480.5 4.5 8e-143 476.5 3.1 2.0 1 1 0 1 1 1 1 PRMT5 arginine-N-methyltransferase CKS PF01111.14 CDF89679.1 - 5.1e-35 119.1 0.1 7.5e-35 118.6 0.0 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit PI3_PI4_kinase PF00454.22 CDF89680.1 - 1.1e-48 165.8 0.2 2.9e-48 164.4 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase UME PF08064.8 CDF89680.1 - 1.5e-32 111.6 0.5 4e-31 107.1 0.9 3.0 2 0 0 2 2 2 1 UME (NUC010) domain FATC PF02260.15 CDF89680.1 - 4.9e-14 51.4 0.1 1e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 FATC domain FAT PF02259.18 CDF89680.1 - 3.6e-13 49.2 0.2 3.4e-12 46.0 0.2 2.5 1 1 0 1 1 1 1 FAT domain TPR_19 PF14559.1 CDF89680.1 - 0.058 13.7 0.0 0.21 11.9 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF429 PF04250.8 CDF89680.1 - 0.18 11.0 0.0 0.35 10.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF429) DUF2404 PF10296.4 CDF89681.1 - 1.9e-28 98.4 0.0 4.4e-28 97.2 0.0 1.7 1 0 0 1 1 1 1 Putative integral membrane protein conserved region (DUF2404) PH PF00169.24 CDF89681.1 - 2.1e-11 43.9 0.5 2.1e-11 43.9 0.4 2.0 2 0 0 2 2 2 1 PH domain PH_11 PF15413.1 CDF89681.1 - 0.0085 16.3 4.2 0.016 15.4 0.0 3.2 2 2 1 3 3 3 1 Pleckstrin homology domain PTRF_SDPR PF15237.1 CDF89681.1 - 2.9 7.2 11.6 1.5 8.1 6.1 1.6 1 1 1 2 2 2 0 PTRF/SDPR family Cofilin_ADF PF00241.15 CDF89683.1 - 5.5e-25 87.6 0.0 1e-15 57.6 0.0 2.5 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein zf-RING_2 PF13639.1 CDF89684.1 - 6.7e-10 38.6 26.8 8e-09 35.2 4.9 3.0 2 1 1 3 3 3 2 Ring finger domain zf-C3HC4_3 PF13920.1 CDF89684.1 - 3.4e-07 29.8 18.4 5.7e-06 25.9 2.3 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDF89684.1 - 3.1e-06 26.7 5.0 3.1e-06 26.7 3.4 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDF89684.1 - 4.9e-06 26.4 22.7 1.1e-05 25.4 4.5 2.5 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 CDF89684.1 - 2.6e-05 24.2 4.6 2.6e-05 24.2 3.2 3.0 2 1 0 2 2 2 1 RING-H2 zinc finger zf-RING_5 PF14634.1 CDF89684.1 - 3.4e-05 23.4 5.6 3.4e-05 23.4 3.9 2.8 2 1 0 2 2 2 1 zinc-RING finger domain zf-Apc11 PF12861.2 CDF89684.1 - 0.00043 20.0 3.1 0.00043 20.0 2.2 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_1 PF14446.1 CDF89684.1 - 0.014 15.1 4.4 0.014 15.1 3.0 3.8 2 2 2 4 4 4 0 Prokaryotic RING finger family 1 zf-HC5HC2H_2 PF13832.1 CDF89684.1 - 0.024 14.6 11.3 0.36 10.8 2.1 2.6 2 1 0 2 2 2 0 PHD-zinc-finger like domain PHD PF00628.24 CDF89684.1 - 0.47 10.1 24.3 0.32 10.7 7.4 2.9 2 2 0 2 2 2 0 PHD-finger RINGv PF12906.2 CDF89684.1 - 4.7 7.3 24.8 0.14 12.1 4.0 2.6 2 0 0 2 2 2 0 RING-variant domain PHF5 PF03660.9 CDF89685.1 - 1.6e-49 166.4 12.4 1.8e-49 166.2 8.6 1.0 1 0 0 1 1 1 1 PHF5-like protein Sec7 PF01369.15 CDF89686.1 - 3.4e-33 114.9 0.7 3.4e-33 114.9 0.5 2.0 2 0 0 2 2 2 1 Sec7 domain DUF3818 PF12825.2 CDF89687.1 - 6.5e-130 432.7 6.3 1.2e-129 431.8 4.4 1.5 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.2 CDF89687.1 - 6.9e-46 155.2 0.9 2.3e-45 153.5 0.6 2.0 1 0 0 1 1 1 1 PX-associated PX PF00787.19 CDF89687.1 - 2.7e-12 46.5 0.0 1.5e-11 44.0 0.0 2.4 1 0 0 1 1 1 1 PX domain CCDC-167 PF15188.1 CDF89687.1 - 0.95 9.4 7.5 7.9 6.4 2.1 2.9 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 SLX9 PF15341.1 CDF89688.1 - 1.9e-17 63.8 10.4 1.9e-17 63.8 7.2 1.8 2 0 0 2 2 2 1 Ribosome biogenesis protein SLX9 DUF4149 PF13664.1 CDF89689.1 - 1.2e-21 76.6 2.3 1.2e-21 76.6 1.6 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) CopD PF05425.8 CDF89689.1 - 0.17 12.0 1.8 0.5 10.6 0.1 2.0 1 1 1 2 2 2 0 Copper resistance protein D L51_S25_CI-B8 PF05047.11 CDF89690.1 - 3.8e-13 48.9 0.0 6e-13 48.3 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain KID PF02524.9 CDF89690.1 - 0.09 12.9 1.3 1.9 8.9 0.2 2.8 2 0 0 2 2 2 0 KID repeat IF-2B PF01008.12 CDF89691.1 - 9.7e-104 346.2 0.0 9.7e-104 346.2 0.0 1.7 2 0 0 2 2 2 1 Initiation factor 2 subunit family DeoRC PF00455.17 CDF89691.1 - 5.8e-05 22.7 0.2 0.0029 17.2 0.1 2.6 1 1 0 1 1 1 1 DeoR C terminal sensor domain Med15 PF09606.5 CDF89691.1 - 0.018 13.3 9.5 0.025 12.8 6.6 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF2031 PF09592.5 CDF89691.1 - 0.93 8.6 19.2 0.2 10.7 9.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2031) LMBR1 PF04791.11 CDF89691.1 - 2.6 6.5 6.8 4.1 5.8 4.7 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF775 PF05603.7 CDF89691.1 - 8.6 5.8 10.0 20 4.6 6.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF775) BBP1_C PF15272.1 CDF89692.1 - 0.052 13.1 0.3 0.1 12.1 0.2 1.4 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal BCAS2 PF05700.6 CDF89693.1 - 0.00012 21.6 5.0 0.00016 21.2 3.5 1.2 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Ribosomal_L5_C PF00673.16 CDF89694.1 - 5.4e-24 83.7 0.0 8.1e-24 83.1 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 CDF89694.1 - 5.6e-20 70.8 0.1 1.3e-19 69.6 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L5 Tis11B_N PF04553.7 CDF89694.1 - 0.08 13.1 0.9 0.57 10.3 0.1 2.5 1 1 2 3 3 3 0 Tis11B like protein, N terminus ApbA PF02558.11 CDF89694.1 - 0.11 11.8 0.0 0.24 10.8 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Proteasome PF00227.21 CDF89695.1 - 1.7e-49 167.6 0.2 2.1e-49 167.3 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Fork_head PF00250.13 CDF89696.1 - 8.5e-33 112.2 0.1 8.5e-33 112.2 0.1 1.8 2 0 0 2 2 2 1 Fork head domain FHA PF00498.21 CDF89696.1 - 4.4e-12 45.9 0.3 9.3e-12 44.9 0.2 1.6 1 0 0 1 1 1 1 FHA domain Pil1 PF13805.1 CDF89697.1 - 3.4e-154 511.7 0.3 4.1e-154 511.5 0.2 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 zf-CCCH PF00642.19 CDF89698.1 - 3.9e-11 42.3 28.1 0.002 17.7 0.2 5.8 5 1 0 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 CDF89698.1 - 0.027 14.4 25.2 1.2 9.2 0.5 5.0 4 1 0 4 4 4 0 Zinc finger C-x8-C-x5-C-x3-H type RPN7 PF10602.4 CDF89699.1 - 8.7e-55 184.8 2.2 1.7e-54 183.8 1.5 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.22 CDF89699.1 - 2.2e-15 56.8 0.7 8.9e-15 54.9 0.0 2.4 4 0 0 4 4 3 1 PCI domain TPR_12 PF13424.1 CDF89699.1 - 0.00016 21.5 0.5 0.0027 17.6 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat PCI_Csn8 PF10075.4 CDF89699.1 - 0.00095 18.9 0.0 0.0022 17.7 0.0 1.7 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 Peptidase_M13_N PF05649.8 CDF89699.1 - 0.0014 17.7 0.4 0.0026 16.8 0.3 1.4 1 0 0 1 1 1 1 Peptidase family M13 TPR_8 PF13181.1 CDF89699.1 - 0.0018 17.9 0.1 0.008 15.8 0.1 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.12 CDF89699.1 - 0.0049 16.6 0.6 0.14 12.1 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 CDF89699.1 - 0.0098 15.6 0.2 1.6 8.6 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.1 CDF89699.1 - 0.017 15.7 0.0 1.4 9.7 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_15 PF13429.1 CDF89699.1 - 0.024 13.6 0.3 0.056 12.4 0.1 1.6 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.1 CDF89699.1 - 0.037 13.6 0.2 0.16 11.6 0.1 2.1 2 0 0 2 2 2 0 TPR repeat DUF4259 PF14078.1 CDF89699.1 - 0.075 13.5 0.9 0.19 12.2 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4259) DUF357 PF04010.8 CDF89699.1 - 0.083 12.6 0.1 0.23 11.1 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF357) RNA_pol_Rpb2_2 PF04561.9 CDF89699.1 - 0.1 12.0 0.3 0.17 11.2 0.2 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 2 PAXNEB PF05625.6 CDF89699.1 - 0.11 11.3 0.2 0.19 10.5 0.1 1.4 1 0 0 1 1 1 0 PAXNEB protein TPR_1 PF00515.23 CDF89699.1 - 0.48 10.1 2.8 0.65 9.7 0.2 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat ELO PF01151.13 CDF89700.1 - 1.3e-60 204.8 23.2 1.6e-60 204.5 16.1 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family RNase_PH PF01138.16 CDF89701.1 - 2.4e-23 82.9 0.0 7.4e-23 81.3 0.0 1.8 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 CDF89701.1 - 0.096 12.6 0.4 0.26 11.2 0.2 1.8 1 1 0 1 1 1 0 3' exoribonuclease family, domain 2 PfkB PF00294.19 CDF89702.1 - 2.1e-43 148.6 3.0 8.2e-43 146.6 2.0 1.7 1 1 0 1 1 1 1 pfkB family carbohydrate kinase UCH PF00443.24 CDF89703.1 - 9.6e-93 310.1 0.5 3.2e-91 305.1 0.4 2.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CDF89703.1 - 2.7e-23 82.8 5.4 6.9e-13 48.6 0.3 2.5 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.7 CDF89703.1 - 0.0005 20.4 3.7 0.0008 19.7 0.0 3.2 3 0 0 3 3 3 1 DUSP domain Rubredoxin PF00301.15 CDF89703.1 - 0.17 11.7 1.5 0.48 10.3 0.1 2.3 2 0 0 2 2 2 0 Rubredoxin SPX PF03105.14 CDF89704.1 - 2.2e-42 145.7 17.1 3.5e-42 145.0 11.9 1.3 1 0 0 1 1 1 1 SPX domain CitMHS PF03600.11 CDF89704.1 - 2.8e-12 45.8 18.9 2.8e-12 45.8 13.1 2.4 2 1 1 3 3 3 1 Citrate transporter DctM PF06808.7 CDF89704.1 - 9.3e-07 27.7 35.9 0.00015 20.4 10.3 2.3 1 1 1 2 2 2 2 DctM-like transporters Aconitase PF00330.15 CDF89705.1 - 1.6e-171 570.8 0.0 3.2e-171 569.9 0.0 1.5 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 CDF89705.1 - 1.6e-42 144.7 0.0 3e-42 143.8 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain RasGEF PF00617.14 CDF89706.1 - 2.3e-50 170.9 0.2 6.9e-50 169.3 0.2 1.9 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 CDF89706.1 - 9.2e-18 64.2 2.2 4.2e-17 62.1 0.8 2.8 2 0 0 2 2 2 1 RasGEF N-terminal motif SH3_1 PF00018.23 CDF89706.1 - 9.7e-05 21.6 0.0 0.00021 20.5 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 CDF89706.1 - 0.027 13.9 0.0 0.058 12.8 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain CRAL_TRIO_2 PF13716.1 CDF89707.1 - 7.7e-32 110.2 2.4 1.8e-31 109.0 1.7 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain RhoGAP PF00620.22 CDF89707.1 - 7.1e-09 35.4 1.4 1.3e-08 34.6 0.3 2.0 2 0 0 2 2 2 1 RhoGAP domain PRP21_like_P PF12230.3 CDF89708.1 - 2.6e-33 115.4 7.1 5e-31 107.9 4.9 2.3 1 1 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.15 CDF89708.1 - 3.2e-14 52.2 2.4 2.3e-08 33.5 0.2 2.8 2 0 0 2 2 2 2 Surp module Sec10 PF07393.6 CDF89709.1 - 1.1e-63 215.5 25.0 1.3e-63 215.3 17.3 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 TetR_C_8 PF14278.1 CDF89709.1 - 0.0055 17.0 1.0 0.0055 17.0 0.7 5.1 6 0 0 6 6 6 1 Transcriptional regulator C-terminal region Spore_III_AB PF09548.5 CDF89709.1 - 0.76 9.5 12.6 0.12 12.0 2.5 2.9 3 0 0 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) F-box-like PF12937.2 CDF89710.1 - 0.021 14.5 1.5 0.055 13.2 1.1 1.8 1 1 0 1 1 1 0 F-box-like F-box PF00646.28 CDF89710.1 - 0.024 14.2 1.8 0.15 11.7 1.2 2.3 2 0 0 2 2 2 0 F-box domain Fungal_trans PF04082.13 CDF89711.1 - 3.2e-31 108.1 1.1 4.7e-31 107.6 0.8 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF89711.1 - 4.8e-09 35.9 16.4 1.1e-08 34.8 11.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Endonuclease_NS PF01223.18 CDF89713.1 - 1.3e-58 198.0 0.0 1.5e-58 197.8 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease DUF3137 PF11335.3 CDF89714.1 - 0.046 13.3 0.6 0.69 9.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3137) Pex2_Pex12 PF04757.9 CDF89715.1 - 1.7e-13 50.5 14.3 3.6e-13 49.4 9.9 1.5 1 1 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.1 CDF89715.1 - 0.0061 16.5 15.3 0.013 15.4 10.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CDF89715.1 - 3.2 7.4 12.4 5.8 6.6 8.6 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_clus PF00172.13 CDF89716.1 - 4.9e-07 29.5 10.6 1.5e-06 27.9 7.3 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mito_carr PF00153.22 CDF89717.1 - 5.6e-60 199.0 0.2 1.3e-20 72.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein MFS_1 PF07690.11 CDF89719.1 - 2.5e-29 102.1 25.8 2.5e-29 102.1 17.9 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.11 CDF89720.1 - 7.8e-28 97.1 47.7 7.8e-28 97.1 33.1 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_3 PF05977.8 CDF89720.1 - 0.00079 17.6 3.2 0.0013 16.9 2.2 1.3 1 0 0 1 1 1 1 Transmembrane secretion effector Methyltransf_31 PF13847.1 CDF89721.1 - 9.6e-14 51.2 0.0 1.5e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDF89721.1 - 1.4e-12 47.8 0.0 3.4e-12 46.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDF89721.1 - 3.9e-11 43.2 0.0 6.9e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDF89721.1 - 1e-10 41.8 0.0 1.9e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDF89721.1 - 3.9e-08 33.8 0.0 6.8e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CDF89721.1 - 2.4e-07 30.1 0.0 3.6e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.1 CDF89721.1 - 2.8e-05 23.9 0.0 4.9e-05 23.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.1 CDF89721.1 - 4.2e-05 23.2 0.0 7.5e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CDF89721.1 - 0.0003 19.8 0.0 0.0014 17.6 0.0 2.0 3 0 0 3 3 3 1 Putative methyltransferase Methyltransf_26 PF13659.1 CDF89721.1 - 0.0012 18.8 0.0 0.0055 16.7 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain CMAS PF02353.15 CDF89721.1 - 0.0035 16.4 0.1 0.027 13.5 0.0 2.1 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase MTS PF05175.9 CDF89721.1 - 0.01 15.1 0.0 0.017 14.4 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain CheR PF01739.13 CDF89721.1 - 0.013 14.8 0.0 0.033 13.4 0.0 1.7 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain MFS_1 PF07690.11 CDF89722.1 - 3.6e-31 108.1 39.9 3.6e-31 108.1 27.7 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.8 CDF89722.1 - 8.7e-05 20.9 5.7 0.00013 20.3 3.9 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Hexokinase_2 PF03727.11 CDF89726.1 - 4.8e-97 323.9 0.0 7.3e-97 323.3 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.16 CDF89726.1 - 6.1e-82 273.9 0.0 8.3e-82 273.4 0.0 1.2 1 0 0 1 1 1 1 Hexokinase FGGY_N PF00370.16 CDF89726.1 - 0.0059 15.9 0.0 0.0089 15.3 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain SAC3_GANP PF03399.11 CDF89727.1 - 9.6e-31 106.9 1.0 1.5e-30 106.2 0.7 1.3 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family PCI_Csn8 PF10075.4 CDF89727.1 - 3.2e-20 72.3 0.2 5e-20 71.7 0.1 1.3 1 0 0 1 1 1 1 COP9 signalosome, subunit CSN8 Ppx-GppA PF02541.11 CDF89728.1 - 9.3e-72 241.6 0.0 1.2e-71 241.2 0.0 1.1 1 0 0 1 1 1 1 Ppx/GppA phosphatase family DUF2420 PF10336.4 CDF89730.1 - 3.4e-35 120.0 0.2 5.7e-35 119.3 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) Clat_adaptor_s PF01217.15 CDF89731.1 - 2.9e-08 33.5 2.0 5.4e-08 32.6 1.4 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Adap_comp_sub PF00928.16 CDF89731.1 - 3.4e-07 29.6 0.2 6e-07 28.8 0.0 1.4 2 0 0 2 2 2 1 Adaptor complexes medium subunit family Hom_end_hint PF05203.11 CDF89731.1 - 0.011 15.5 0.1 0.016 14.9 0.1 1.3 1 0 0 1 1 1 0 Hom_end-associated Hint Proteasome PF00227.21 CDF89732.1 - 8.7e-26 90.3 0.1 1.1e-25 89.9 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit PDEase_II PF02112.10 CDF89733.1 - 3.1e-63 213.7 0.0 6.1e-63 212.7 0.0 1.5 1 1 0 1 1 1 1 cAMP phosphodiesterases class-II Lactamase_B_2 PF12706.2 CDF89733.1 - 5.2e-10 39.1 0.0 8.3e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain DUF2638 PF10937.3 CDF89734.1 - 8e-26 91.2 0.1 9.7e-26 90.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2638) Aldo_ket_red PF00248.16 CDF89735.1 - 1.6e-46 158.4 0.0 1.8e-46 158.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family tRNA-synt_1c PF00749.16 CDF89737.1 - 4.6e-111 370.4 0.2 6.2e-111 370.0 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 CDF89737.1 - 4.7e-41 140.3 1.3 4.5e-40 137.1 0.1 2.4 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C_3 PF14497.1 CDF89737.1 - 3e-05 24.4 0.0 7.7e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 CDF89737.1 - 0.00075 19.4 0.0 0.0016 18.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.1 CDF89737.1 - 0.0026 17.6 0.0 0.0059 16.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF155 PF02582.9 CDF89738.1 - 1.4e-58 197.6 0.1 2.8e-58 196.6 0.1 1.5 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Plus-3 PF03126.13 CDF89739.1 - 2.9e-31 107.7 0.3 2.9e-31 107.7 0.2 2.4 2 0 0 2 2 2 1 Plus-3 domain Ribosomal_S20p PF01649.13 CDF89739.1 - 0.025 14.9 1.1 0.025 14.9 0.7 3.1 2 1 0 3 3 3 0 Ribosomal protein S20 A_deamin PF02137.13 CDF89740.1 - 2.4e-62 211.2 0.0 2.8e-62 211.0 0.0 1.0 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain Ank PF00023.25 CDF89741.1 - 1.3e-10 40.5 0.3 0.00082 19.0 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeat Ank_2 PF12796.2 CDF89741.1 - 9.5e-09 35.4 0.0 7e-06 26.3 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.1 CDF89741.1 - 3e-08 33.6 0.2 8.5e-05 22.6 0.1 3.2 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.1 CDF89741.1 - 7.9e-08 32.6 0.6 0.0012 19.2 0.0 3.1 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDF89741.1 - 2e-07 30.5 0.0 0.00083 19.3 0.0 3.2 3 1 0 3 3 3 2 Ankyrin repeat IBN_N PF03810.14 CDF89742.1 - 3.9e-07 29.8 0.0 4.2e-06 26.5 0.0 2.9 2 1 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.7 CDF89742.1 - 0.0053 16.6 7.1 0.13 12.1 0.0 4.5 4 1 0 4 4 4 2 Exportin 1-like protein DUF3826 PF12875.2 CDF89742.1 - 0.017 14.7 0.2 0.11 12.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3826) APC10 PF03256.11 CDF89743.1 - 5.7e-56 189.1 0.1 7.4e-56 188.8 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.20 CDF89743.1 - 0.00045 20.0 0.1 0.0011 18.7 0.0 1.7 2 1 0 2 2 2 1 F5/8 type C domain Sad1_UNC PF07738.8 CDF89743.1 - 0.12 12.1 0.2 0.94 9.2 0.0 2.1 2 0 0 2 2 2 0 Sad1 / UNC-like C-terminal Cse1 PF08506.5 CDF89744.1 - 3e-169 562.4 11.2 3e-169 562.4 7.7 1.7 2 0 0 2 2 2 1 Cse1 CAS_CSE1 PF03378.10 CDF89744.1 - 3.4e-107 358.4 12.5 1.1e-106 356.8 5.2 2.3 2 0 0 2 2 2 2 CAS/CSE protein, C-terminus IBN_N PF03810.14 CDF89744.1 - 3.3e-18 65.3 0.2 5e-15 55.1 0.0 4.3 4 0 0 4 4 4 1 Importin-beta N-terminal domain Xpo1 PF08389.7 CDF89744.1 - 0.024 14.5 0.3 0.024 14.5 0.2 4.2 5 1 0 5 5 5 0 Exportin 1-like protein CBFB_NFYA PF02045.10 CDF89745.1 - 6.8e-28 96.9 8.7 1.3e-27 96.1 6.1 1.5 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B GIDA PF01134.17 CDF89747.1 - 4.7e-155 516.2 0.0 6.4e-155 515.8 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc_3 PF13932.1 CDF89747.1 - 4.6e-21 74.6 0.0 1.2e-20 73.3 0.0 1.7 1 0 0 1 1 1 1 GidA associated domain 3 Pyr_redox_2 PF07992.9 CDF89747.1 - 1.2e-06 28.6 0.2 3.1e-06 27.2 0.2 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CDF89747.1 - 2.6e-06 26.5 2.0 0.0066 15.3 0.0 2.6 3 0 0 3 3 3 2 FAD dependent oxidoreductase FAD_oxidored PF12831.2 CDF89747.1 - 6.5e-05 22.1 0.1 0.0001 21.5 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 CDF89747.1 - 0.0078 15.1 2.1 0.0078 15.1 1.5 1.9 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.22 CDF89747.1 - 0.012 16.0 0.3 0.03 14.7 0.2 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CDF89747.1 - 0.014 13.9 1.6 0.77 8.1 0.5 2.4 2 0 0 2 2 2 0 HI0933-like protein GARS_A PF01071.14 CDF89748.1 - 8e-82 273.5 0.0 1.2e-81 272.8 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.10 CDF89748.1 - 3.5e-33 114.0 0.0 1e-32 112.5 0.0 1.8 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.11 CDF89748.1 - 2.6e-28 98.0 0.2 7.1e-28 96.6 0.2 1.8 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS_C PF02769.17 CDF89748.1 - 1.1e-27 96.8 0.0 2.6e-27 95.7 0.0 1.6 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.19 CDF89748.1 - 1.1e-16 60.8 1.4 4e-15 55.8 0.7 3.2 3 0 0 3 3 3 1 AIR synthase related protein, N-terminal domain ATP-grasp_4 PF13535.1 CDF89748.1 - 6.6e-13 48.7 0.0 4.6e-12 46.0 0.0 2.3 2 1 0 2 2 2 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 CDF89748.1 - 1.3e-07 30.7 0.0 3.6e-07 29.2 0.0 1.7 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 CDF89748.1 - 4.9e-07 29.2 0.0 9.7e-07 28.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.9 CDF89748.1 - 2.7e-06 27.3 0.2 9.3e-06 25.5 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.12 CDF89748.1 - 4.8e-05 22.7 0.0 8.9e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain RimK PF08443.6 CDF89748.1 - 0.0064 15.9 0.0 0.013 14.9 0.0 1.5 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Dala_Dala_lig_C PF07478.8 CDF89748.1 - 0.082 12.2 0.0 0.51 9.6 0.0 2.1 2 0 0 2 2 2 0 D-ala D-ala ligase C-terminus Mito_carr PF00153.22 CDF89749.1 - 5.6e-44 147.7 2.0 3.7e-20 71.4 0.2 4.4 3 2 0 3 3 3 3 Mitochondrial carrier protein Peptidase_M20 PF01546.23 CDF89750.1 - 1.7e-28 99.4 0.0 2.5e-28 98.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 CDF89750.1 - 1.5e-13 50.4 0.0 2.7e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Sec15 PF04091.7 CDF89751.1 - 2.1e-106 355.7 10.4 2.1e-106 355.7 7.2 2.1 2 0 0 2 2 2 1 Exocyst complex subunit Sec15-like THUMP PF02926.12 CDF89752.1 - 1.1e-23 83.7 0.8 2e-23 82.8 0.6 1.4 1 0 0 1 1 1 1 THUMP domain DUF1077 PF06417.7 CDF89753.1 - 5.2e-45 151.8 3.2 6.4e-45 151.5 2.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) DUF999 PF06198.6 CDF89753.1 - 0.098 12.4 0.2 0.14 11.9 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF999) DUF3099 PF11298.3 CDF89754.1 - 0.051 13.3 0.0 0.077 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3099) SUR7 PF06687.7 CDF89754.1 - 0.094 12.2 0.1 0.11 12.0 0.1 1.1 1 0 0 1 1 1 0 SUR7/PalI family Adaptin_binding PF10199.4 CDF89755.1 - 0.0015 18.8 8.5 0.065 13.5 0.0 2.5 2 1 1 3 3 3 2 Alpha and gamma adaptin binding protein p34 DnaJ PF00226.26 CDF89757.1 - 2.8e-14 52.5 4.7 2.8e-14 52.5 3.3 2.3 2 0 0 2 2 2 1 DnaJ domain FixQ PF05545.6 CDF89757.1 - 0.15 11.7 0.3 3.9 7.1 0.0 2.5 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ SAPS PF04499.10 CDF89758.1 - 1.9e-158 528.0 30.3 1.9e-158 528.0 21.0 2.9 2 1 0 2 2 2 1 SIT4 phosphatase-associated protein UBN_AB PF14075.1 CDF89758.1 - 0.2 11.2 6.9 0.7 9.5 4.8 1.9 1 0 0 1 1 1 0 Ubinuclein conserved middle domain Tropomyosin_1 PF12718.2 CDF89759.1 - 0.025 14.4 0.4 0.025 14.4 0.2 3.2 3 0 0 3 3 3 0 Tropomyosin like DUF2937 PF11157.3 CDF89759.1 - 0.11 11.7 2.5 0.27 10.5 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2937) AdoHcyase PF05221.12 CDF89760.1 - 6.7e-140 464.6 0.1 7.7e-140 464.4 0.1 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 CDF89760.1 - 1.3e-84 281.9 1.5 2e-84 281.3 1.0 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 CDF89760.1 - 3.8e-07 29.4 0.1 7.4e-07 28.4 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 CDF89760.1 - 6.7e-05 22.3 0.2 0.00012 21.4 0.1 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain TrkA_N PF02254.13 CDF89760.1 - 0.0089 16.0 0.0 0.018 15.0 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain FdtA PF05523.6 CDF89760.1 - 0.086 12.3 0.0 0.24 10.9 0.0 1.7 2 0 0 2 2 2 0 WxcM-like, C-terminal DUF4448 PF14610.1 CDF89760.1 - 0.088 12.2 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) SPRY PF00622.23 CDF89761.1 - 4.9e-21 75.0 0.4 1.1e-20 73.9 0.2 1.6 1 0 0 1 1 1 1 SPRY domain CLTH PF10607.4 CDF89761.1 - 1e-13 51.2 3.8 4e-13 49.2 2.3 2.1 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain PRP21_like_P PF12230.3 CDF89761.1 - 0.23 10.9 5.0 0.66 9.4 1.8 2.2 2 0 0 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein CDC45 PF02724.9 CDF89761.1 - 1.1 7.1 17.0 0.014 13.4 5.2 2.0 2 0 0 2 2 2 0 CDC45-like protein Daxx PF03344.10 CDF89761.1 - 8.5 4.7 19.6 0.025 13.1 6.1 1.9 2 0 0 2 2 2 0 Daxx Family COX4 PF02936.9 CDF89762.1 - 4.3e-14 52.4 0.0 4.8e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV N1221 PF07923.8 CDF89762.1 - 0.00022 20.1 0.0 0.00024 20.0 0.0 1.1 1 0 0 1 1 1 1 N1221-like protein PMSR PF01625.16 CDF89763.1 - 1e-50 171.6 0.1 1.3e-50 171.3 0.1 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase XPG_I PF00867.13 CDF89764.1 - 2e-21 75.8 0.0 5.4e-21 74.4 0.0 1.8 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 CDF89764.1 - 4.4e-05 23.6 0.2 0.0004 20.6 0.0 2.5 2 0 0 2 2 2 1 XPG N-terminal domain Phage_Mu_Gam PF07352.7 CDF89764.1 - 0.17 11.4 0.3 0.75 9.3 0.0 2.0 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein GATA PF00320.22 CDF89765.1 - 1.4e-15 56.3 2.9 3.2e-15 55.1 2.0 1.7 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.7 CDF89765.1 - 0.05 12.9 0.3 0.094 12.0 0.2 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding UAA PF08449.6 CDF89766.1 - 1.3e-13 50.5 25.3 2.6e-13 49.5 17.6 1.4 1 1 1 2 2 2 1 UAA transporter family TPT PF03151.11 CDF89766.1 - 3.3e-09 36.5 10.1 3.3e-09 36.5 7.0 2.8 2 1 0 2 2 2 1 Triose-phosphate Transporter family Nuc_sug_transp PF04142.10 CDF89766.1 - 0.00066 18.8 4.9 0.00066 18.8 3.4 2.1 3 0 0 3 3 3 1 Nucleotide-sugar transporter Helicase_C_4 PF13871.1 CDF89766.1 - 0.019 14.3 0.0 0.032 13.6 0.0 1.2 1 0 0 1 1 1 0 Helicase_C-like Nse5 PF08691.5 CDF89767.1 - 4.4e-21 74.9 1.8 7.6e-21 74.1 1.2 1.3 1 0 0 1 1 1 1 DNA repair proteins Nse5 and Nse6 Nuf2 PF03800.9 CDF89767.1 - 0.054 13.4 0.1 3.1 7.7 0.0 2.2 2 0 0 2 2 2 0 Nuf2 family HAD_2 PF13419.1 CDF89768.1 - 4.3e-25 88.9 0.0 5.6e-25 88.5 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Acid_PPase PF12689.2 CDF89768.1 - 0.015 14.9 0.0 0.3 10.7 0.0 2.1 2 0 0 2 2 2 0 Acid Phosphatase ABC_tran PF00005.22 CDF89770.1 - 3e-50 170.0 1.9 1.5e-25 90.1 0.0 3.2 4 0 0 4 4 2 2 ABC transporter AAA_21 PF13304.1 CDF89770.1 - 5.3e-23 82.3 2.8 4e-07 30.2 0.0 4.4 2 2 0 3 3 3 3 AAA domain ABC_tran_2 PF12848.2 CDF89770.1 - 1.2e-20 73.0 1.9 1.2e-20 73.0 1.3 2.9 3 0 0 3 3 1 1 ABC transporter SMC_N PF02463.14 CDF89770.1 - 3.6e-09 36.1 7.9 0.23 10.6 0.0 4.9 4 1 0 5 5 5 4 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 CDF89770.1 - 2.1e-08 33.5 0.0 0.001 18.5 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_18 PF13238.1 CDF89770.1 - 1.5e-07 31.8 0.9 0.0029 17.9 0.0 3.6 4 1 0 4 4 3 2 AAA domain AAA_22 PF13401.1 CDF89770.1 - 2.6e-07 30.8 0.0 0.028 14.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 CDF89770.1 - 4.6e-07 29.1 0.0 0.00021 20.5 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Miro PF08477.8 CDF89770.1 - 5.1e-07 30.1 0.0 0.029 14.8 0.0 2.8 2 0 0 2 2 2 2 Miro-like protein AAA_17 PF13207.1 CDF89770.1 - 8.3e-07 29.8 0.0 0.1 13.4 0.0 3.2 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.1 CDF89770.1 - 2.1e-06 28.2 14.5 0.001 19.4 0.0 4.1 4 0 0 4 4 3 2 AAA domain MMR_HSR1 PF01926.18 CDF89770.1 - 4.9e-06 26.4 0.2 0.03 14.2 0.1 3.6 3 2 1 4 4 3 2 50S ribosome-binding GTPase AAA_15 PF13175.1 CDF89770.1 - 1.7e-05 24.0 0.8 0.39 9.6 0.0 4.1 3 2 0 4 4 3 2 AAA ATPase domain NACHT PF05729.7 CDF89770.1 - 4.3e-05 23.2 0.9 0.28 10.8 0.0 2.8 3 0 0 3 3 2 2 NACHT domain RNA_helicase PF00910.17 CDF89770.1 - 4.8e-05 23.4 0.0 0.26 11.4 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA PF00004.24 CDF89770.1 - 6.9e-05 23.0 0.0 0.14 12.3 0.0 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.1 CDF89770.1 - 0.00016 21.6 0.0 0.67 9.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.1 CDF89770.1 - 0.00026 20.8 0.1 0.21 11.4 0.0 2.9 3 0 0 3 3 2 1 AAA domain MCM PF00493.18 CDF89770.1 - 0.0003 19.7 1.4 0.92 8.2 0.0 3.1 3 0 0 3 3 3 1 MCM2/3/5 family AAA_14 PF13173.1 CDF89770.1 - 0.00032 20.6 0.0 1.4 8.8 0.0 3.0 2 0 0 2 2 2 2 AAA domain MobB PF03205.9 CDF89770.1 - 0.00032 20.4 0.2 0.0069 16.0 0.1 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.1 CDF89770.1 - 0.00037 20.5 0.4 0.51 10.3 0.0 3.2 3 1 0 3 3 3 1 AAA ATPase domain AAA_25 PF13481.1 CDF89770.1 - 0.00045 19.6 0.1 1 8.7 0.0 3.3 2 1 0 2 2 2 1 AAA domain AAA_10 PF12846.2 CDF89770.1 - 0.00046 19.7 0.4 0.75 9.1 0.0 3.4 3 1 0 3 3 3 1 AAA-like domain VirE PF05272.6 CDF89770.1 - 0.00078 18.9 0.1 0.33 10.3 0.0 2.8 3 0 0 3 3 3 1 Virulence-associated protein E Dynamin_N PF00350.18 CDF89770.1 - 0.001 18.9 2.8 0.97 9.2 0.0 3.8 3 1 1 4 4 4 1 Dynamin family T2SE PF00437.15 CDF89770.1 - 0.0021 17.0 0.0 0.026 13.4 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein SbcCD_C PF13558.1 CDF89770.1 - 0.0021 17.9 0.1 0.46 10.4 0.0 3.4 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Rad17 PF03215.10 CDF89770.1 - 0.0066 15.1 0.2 1.3 7.6 0.0 2.7 3 0 0 3 3 3 1 Rad17 cell cycle checkpoint protein ArgK PF03308.11 CDF89770.1 - 0.01 14.6 0.1 1.9 7.2 0.0 2.6 3 0 0 3 3 3 0 ArgK protein Arch_ATPase PF01637.13 CDF89770.1 - 0.012 15.2 5.0 2.3 7.8 0.0 3.5 4 1 0 4 4 3 0 Archaeal ATPase AAA_5 PF07728.9 CDF89770.1 - 0.016 14.9 1.1 2.6 7.7 0.0 2.9 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) PduV-EutP PF10662.4 CDF89770.1 - 0.019 14.4 0.2 6.8 6.1 0.0 3.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation DUF815 PF05673.8 CDF89770.1 - 0.021 13.7 0.0 4.4 6.1 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) DAP3 PF10236.4 CDF89770.1 - 0.025 13.5 0.7 5.4 5.8 0.0 2.8 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 NB-ARC PF00931.17 CDF89770.1 - 0.027 13.3 0.1 3.9 6.2 0.0 2.9 2 1 0 2 2 2 0 NB-ARC domain NTPase_1 PF03266.10 CDF89770.1 - 0.047 13.4 0.2 1.8 8.2 0.1 2.8 2 0 0 2 2 2 0 NTPase DUF2813 PF11398.3 CDF89770.1 - 0.052 12.6 0.3 3.8 6.4 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2813) FtsK_SpoIIIE PF01580.13 CDF89770.1 - 0.08 12.4 0.0 2.3 7.6 0.0 2.7 3 0 0 3 3 3 0 FtsK/SpoIIIE family DUF87 PF01935.12 CDF89770.1 - 0.18 11.6 3.1 22 4.7 0.0 3.8 3 1 1 4 4 4 0 Domain of unknown function DUF87 G-alpha PF00503.15 CDF89770.1 - 6.7 5.2 10.7 16 4.0 0.0 3.3 2 1 0 2 2 2 0 G-protein alpha subunit FAM220 PF15487.1 CDF89771.1 - 1.9 7.7 17.4 2.5 7.4 5.6 2.1 2 0 0 2 2 2 0 FAM220 family DUF3245 PF11595.3 CDF89772.1 - 0.0041 17.4 0.6 0.0041 17.4 0.4 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3245) NIF3 PF01784.13 CDF89773.1 - 8.6e-62 208.8 0.0 1.1e-61 208.5 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) AIF-MLS PF14962.1 CDF89774.1 - 0.032 13.8 1.6 0.055 13.1 1.1 1.3 1 0 0 1 1 1 0 Mitochondria Localisation Sequence Kinesin PF00225.18 CDF89775.1 - 1.4e-112 375.7 0.1 1.9e-112 375.2 0.1 1.2 1 0 0 1 1 1 1 Kinesin motor domain Cyclin PF08613.6 CDF89776.1 - 0.00049 20.5 7.4 0.0059 17.0 5.2 2.3 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.18 CDF89776.1 - 0.035 13.6 0.0 0.035 13.6 0.0 2.6 2 1 0 2 2 2 0 Cyclin, N-terminal domain RskA PF10099.4 CDF89776.1 - 0.11 12.1 9.2 0.2 11.3 6.4 1.4 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DNAP_B_exo_N PF08452.5 CDF89776.1 - 0.16 11.2 1.0 0.26 10.5 0.7 1.3 1 0 0 1 1 1 0 DNA polymerase family B exonuclease domain, N-terminal PAT1 PF09770.4 CDF89776.1 - 1.9 6.6 39.1 3 5.9 27.1 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AUX_IAA PF02309.11 CDF89776.1 - 2.5 7.7 7.1 3.9 7.1 4.9 1.2 1 0 0 1 1 1 0 AUX/IAA family TFIIA PF03153.8 CDF89776.1 - 3.1 7.5 24.8 5.3 6.8 17.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hid1 PF12722.2 CDF89776.1 - 7 4.1 9.8 9.6 3.7 6.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein WD40 PF00400.27 CDF89777.1 - 4.1e-18 64.5 17.7 1.5e-07 31.0 0.2 5.6 6 0 0 6 6 6 4 WD domain, G-beta repeat Lgl_C PF08596.5 CDF89777.1 - 0.023 13.1 0.0 0.066 11.6 0.0 1.7 2 0 0 2 2 2 0 Lethal giant larvae(Lgl) like, C-terminal IKI3 PF04762.7 CDF89777.1 - 0.07 10.9 0.0 0.1 10.4 0.0 1.2 1 0 0 1 1 1 0 IKI3 family PX PF00787.19 CDF89778.1 - 2.3e-12 46.6 0.5 2.3e-12 46.6 0.4 1.8 2 0 0 2 2 2 1 PX domain SNARE PF05739.14 CDF89778.1 - 1.9e-09 37.0 7.0 3.8e-09 36.0 4.9 1.5 1 0 0 1 1 1 1 SNARE domain ATP_bind_3 PF01171.15 CDF89779.1 - 5.9e-18 64.9 0.0 1.1e-17 64.1 0.0 1.4 1 0 0 1 1 1 1 PP-loop family DUF2392 PF10288.4 CDF89779.1 - 0.00066 19.9 0.0 0.0016 18.7 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2392) tRNA_Me_trans PF03054.11 CDF89779.1 - 0.007 14.9 0.0 0.013 14.0 0.0 1.4 1 1 0 1 1 1 1 tRNA methyl transferase Asn_synthase PF00733.16 CDF89779.1 - 0.045 13.2 0.0 0.066 12.7 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase Ras PF00071.17 CDF89782.1 - 8.9e-61 203.9 0.1 1e-60 203.7 0.1 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDF89782.1 - 9.6e-20 71.2 0.0 1.5e-19 70.6 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDF89782.1 - 5.6e-13 48.5 0.0 7.2e-13 48.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 CDF89782.1 - 3.4e-07 30.2 0.0 4.7e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.1 CDF89782.1 - 2.5e-05 23.5 0.1 3e-05 23.2 0.1 1.2 1 0 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.22 CDF89782.1 - 5.6e-05 22.6 0.1 0.00016 21.1 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.7 CDF89782.1 - 0.0009 18.4 0.0 0.0011 18.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF258 PF03193.11 CDF89782.1 - 0.0023 17.1 0.1 0.0048 16.0 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function, DUF258 PduV-EutP PF10662.4 CDF89782.1 - 0.01 15.3 0.0 0.019 14.4 0.0 1.5 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.1 CDF89782.1 - 0.012 15.8 0.1 0.021 14.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.5 CDF89782.1 - 0.013 14.6 0.0 0.02 14.0 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Septin PF00735.13 CDF89782.1 - 0.017 14.1 0.0 0.027 13.4 0.0 1.2 1 0 0 1 1 1 0 Septin AAA_16 PF13191.1 CDF89782.1 - 0.021 14.8 0.2 0.07 13.1 0.1 1.9 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.22 CDF89782.1 - 0.047 13.9 0.2 0.09 13.0 0.1 1.5 1 1 0 1 1 1 0 ABC transporter KAP_NTPase PF07693.9 CDF89782.1 - 0.05 12.5 0.0 0.067 12.1 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain FeoB_N PF02421.13 CDF89782.1 - 0.094 11.9 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B DUF1128 PF06569.6 CDF89782.1 - 0.12 12.0 0.0 0.3 10.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1128) CHZ PF09649.5 CDF89783.1 - 8.7e-20 69.6 1.6 8.7e-20 69.6 1.1 2.2 2 0 0 2 2 2 1 Histone chaperone domain CHZ BUD22 PF09073.5 CDF89783.1 - 1.8 7.5 18.2 2 7.3 12.6 1.0 1 0 0 1 1 1 0 BUD22 LSM PF01423.17 CDF89784.1 - 6.9e-18 63.9 0.2 1.3e-17 63.0 0.1 1.5 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 CDF89784.1 - 0.015 15.2 0.3 0.034 14.0 0.0 1.8 2 0 0 2 2 2 0 Ataxin 2 SM domain DUF3510 PF12022.3 CDF89784.1 - 0.12 12.4 1.1 0.15 12.1 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) Vps51 PF08700.6 CDF89784.1 - 0.67 9.8 4.2 0.73 9.7 1.9 1.7 2 0 0 2 2 2 0 Vps51/Vps67 DUF336 PF03928.9 CDF89785.1 - 1.2e-07 31.5 0.0 2e-07 30.8 0.0 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF336) CamS PF07537.6 CDF89785.1 - 0.014 14.4 1.0 0.2 10.6 1.2 1.9 2 0 0 2 2 2 0 CamS sex pheromone cAM373 precursor DUF2346 PF09803.4 CDF89785.1 - 0.14 12.0 0.7 0.24 11.2 0.5 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2346) Ras PF00071.17 CDF89786.1 - 8e-51 171.6 0.0 9.6e-51 171.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDF89786.1 - 3.3e-17 63.0 0.0 6.7e-17 62.0 0.0 1.5 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 CDF89786.1 - 1.5e-11 43.8 0.0 2e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.17 CDF89786.1 - 0.00064 19.8 0.2 0.0055 16.8 0.1 2.1 1 1 0 1 1 1 1 RNA helicase Gtr1_RagA PF04670.7 CDF89786.1 - 0.00071 18.7 0.0 0.00097 18.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 CDF89786.1 - 0.015 14.5 0.0 0.025 13.8 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit KaiC PF06745.8 CDF89786.1 - 0.019 14.0 0.2 0.028 13.5 0.1 1.2 1 0 0 1 1 1 0 KaiC Pox_A32 PF04665.7 CDF89786.1 - 0.025 13.8 0.1 0.043 13.1 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein G-alpha PF00503.15 CDF89786.1 - 0.032 12.9 2.6 1 7.9 0.1 2.8 2 1 1 3 3 3 0 G-protein alpha subunit AAA_22 PF13401.1 CDF89786.1 - 0.053 13.6 0.2 0.16 12.1 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.1 CDF89786.1 - 0.068 13.0 0.1 0.15 11.9 0.1 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 CDF89786.1 - 0.13 11.8 0.1 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 NACHT domain TPR_19 PF14559.1 CDF89787.1 - 3.8e-06 27.1 0.4 6.8e-06 26.3 0.3 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.23 CDF89787.1 - 0.00026 20.4 0.0 0.0065 16.0 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.12 CDF89787.1 - 0.00041 20.0 0.0 0.013 15.3 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 CDF89787.1 - 0.00045 19.8 0.3 0.0068 16.0 0.0 2.5 3 0 0 3 3 3 1 TPR repeat TPR_14 PF13428.1 CDF89787.1 - 0.0012 19.3 0.6 0.0042 17.5 0.1 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 CDF89787.1 - 0.0028 18.3 0.2 0.014 16.0 0.1 2.1 1 1 0 1 1 1 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 CDF89787.1 - 0.22 11.4 0.2 0.22 11.4 0.2 3.1 3 1 1 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat IF-2B PF01008.12 CDF89788.1 - 8.8e-85 284.0 0.1 5.2e-84 281.5 0.1 1.8 1 1 0 1 1 1 1 Initiation factor 2 subunit family ABC_sub_bind PF04392.7 CDF89788.1 - 0.031 13.2 0.0 0.031 13.2 0.0 1.5 2 0 0 2 2 2 0 ABC transporter substrate binding protein Flagellin_N PF00669.15 CDF89788.1 - 0.057 13.2 3.4 0.12 12.2 2.4 1.4 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region CpXC PF14353.1 CDF89788.1 - 7.7 6.5 6.4 0.46 10.4 0.3 2.0 3 0 0 3 3 3 0 CpXC protein NAD_binding_10 PF13460.1 CDF89789.1 - 5.5e-11 42.8 0.0 1.2e-07 31.8 0.0 2.2 2 0 0 2 2 2 2 NADH(P)-binding Epimerase PF01370.16 CDF89789.1 - 6e-07 29.1 0.0 1.6e-06 27.7 0.0 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CDF89789.1 - 5.6e-06 25.2 0.0 1.6e-05 23.7 0.0 1.7 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.20 CDF89789.1 - 0.00052 19.9 0.0 0.00079 19.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.7 CDF89789.1 - 0.028 13.3 0.0 2.7 6.8 0.0 2.2 2 0 0 2 2 2 0 Male sterility protein RmlD_sub_bind PF04321.12 CDF89789.1 - 0.036 12.9 0.0 0.058 12.2 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain GTP_EFTU PF00009.22 CDF89790.1 - 1.4e-48 164.8 0.0 2.5e-48 164.0 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.7 CDF89790.1 - 1e-38 131.4 9.8 5.8e-38 129.1 6.7 2.2 2 0 0 2 2 2 1 GTP-binding protein LepA C-terminus EFG_C PF00679.19 CDF89790.1 - 9.1e-17 60.7 0.0 1.6e-16 59.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.18 CDF89790.1 - 3.4e-05 23.7 0.0 0.00012 22.0 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.20 CDF89790.1 - 9.7e-05 22.4 0.3 0.00027 21.0 0.2 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Ras PF00071.17 CDF89790.1 - 0.00027 20.3 0.6 0.00054 19.3 0.0 1.7 2 0 0 2 2 2 1 Ras family SRPRB PF09439.5 CDF89790.1 - 0.0014 17.8 0.0 0.0033 16.6 0.0 1.6 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit EFG_II PF14492.1 CDF89790.1 - 0.018 14.9 0.0 0.062 13.1 0.0 2.0 1 0 0 1 1 1 0 Elongation Factor G, domain II Hus1 PF04005.7 CDF89791.1 - 1.1e-24 86.9 1.7 3e-23 82.2 1.2 2.1 1 1 0 1 1 1 1 Hus1-like protein Rab5-bind PF09311.6 CDF89791.1 - 0.058 13.2 2.5 0.1 12.4 1.7 1.4 1 0 0 1 1 1 0 Rabaptin-like protein Aminotran_5 PF00266.14 CDF89792.1 - 7.5e-34 117.0 0.0 1.7e-33 115.8 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class-V Lipl32 PF12103.3 CDF89792.1 - 0.13 11.7 0.3 0.25 10.7 0.2 1.4 1 0 0 1 1 1 0 Surface lipoprotein of Spirochaetales order Ribosomal_S30 PF04758.9 CDF89793.1 - 1.6e-29 101.4 5.5 1.8e-29 101.2 3.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 GCIP PF13324.1 CDF89794.1 - 1.3e-12 47.5 0.1 1.8e-12 47.1 0.1 1.2 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting Adeno_E1A PF02703.9 CDF89794.1 - 0.04 13.3 0.1 0.04 13.3 0.1 1.9 2 0 0 2 2 2 0 Early E1A protein DUF1143 PF06608.6 CDF89794.1 - 0.093 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1143) WH1 PF00568.18 CDF89795.1 - 5.1e-32 109.8 0.0 7.5e-32 109.3 0.0 1.2 1 0 0 1 1 1 1 WH1 domain WH2 PF02205.15 CDF89795.1 - 4e-06 26.2 1.1 7.7e-06 25.3 0.8 1.5 1 0 0 1 1 1 1 WH2 motif Methyltransf_16 PF10294.4 CDF89797.1 - 7.5e-17 61.3 0.0 1e-16 60.8 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.1 CDF89797.1 - 0.00013 21.7 0.0 0.00021 21.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDF89797.1 - 0.00045 20.7 0.0 0.00073 20.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDF89797.1 - 0.035 14.5 0.0 0.055 13.9 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 CDF89797.1 - 0.093 13.2 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain ECH PF00378.15 CDF89798.1 - 2.6e-15 56.2 0.0 4.1e-15 55.5 0.0 1.3 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family SPA PF08616.5 CDF89798.1 - 0.07 12.8 0.1 0.43 10.2 0.0 2.0 2 0 0 2 2 2 0 Stabilization of polarity axis DUF1640 PF07798.6 CDF89799.1 - 3.1e-09 37.1 6.7 3.1e-09 37.1 4.6 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1640) RRF_GI PF12614.3 CDF89799.1 - 0.14 11.9 4.1 0.095 12.5 0.8 2.2 3 0 0 3 3 3 0 Ribosome recycling factor RF-1 PF00472.15 CDF89800.1 - 1.3e-18 66.8 8.5 4.2e-18 65.1 5.9 1.7 1 1 0 1 1 1 1 RF-1 domain DUF2353 PF09789.4 CDF89800.1 - 0.081 12.1 9.2 0.1 11.8 6.4 1.1 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) Peptidase_S49_N PF08496.5 CDF89800.1 - 1.3 8.8 8.5 1.7 8.4 5.9 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal ECH PF00378.15 CDF89801.1 - 4.3e-20 71.8 0.0 5.5e-20 71.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family Fungal_trans PF04082.13 CDF89802.1 - 6e-20 71.2 2.5 1.4e-19 69.9 1.7 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF89802.1 - 2.2e-05 24.2 11.9 6.3e-05 22.8 8.2 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Collagen PF01391.13 CDF89802.1 - 0.0051 16.3 5.3 0.0091 15.5 3.7 1.3 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) CPSF73-100_C PF11718.3 CDF89803.1 - 2.1e-61 207.0 4.3 3.4e-61 206.3 3.0 1.3 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.3 CDF89803.1 - 1.5e-32 112.2 0.0 8.1e-32 109.8 0.0 2.3 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B PF00753.22 CDF89803.1 - 1.9e-16 60.2 0.6 3.1e-16 59.5 0.4 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 CDF89803.1 - 4.7e-14 52.3 0.5 6.4e-13 48.6 0.2 2.3 2 0 0 2 2 2 1 Beta-lactamase superfamily domain RMMBL PF07521.7 CDF89803.1 - 6.5e-11 41.8 0.0 1.3e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase Lactamase_B_3 PF13483.1 CDF89803.1 - 4.3e-06 26.5 0.0 1.9e-05 24.4 0.0 1.9 1 1 0 1 1 1 1 Beta-lactamase superfamily domain DEAD PF00270.24 CDF89804.1 - 1.2e-39 135.4 1.9 1.8e-39 134.9 0.7 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF89804.1 - 2.8e-23 81.5 0.2 6.4e-11 41.9 0.0 2.9 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.10 CDF89804.1 - 1.5e-07 31.4 1.6 7.6e-06 25.8 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DnaI_N PF07319.6 CDF89804.1 - 0.17 12.1 2.9 1.6 9.0 0.1 3.0 2 0 0 2 2 2 0 Primosomal protein DnaI N-terminus LSM PF01423.17 CDF89805.1 - 3.4e-18 64.9 1.1 4.3e-18 64.6 0.7 1.1 1 0 0 1 1 1 1 LSM domain MCM PF00493.18 CDF89806.1 - 6.4e-141 468.9 0.1 8.5e-141 468.5 0.1 1.1 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 CDF89806.1 - 1e-18 67.9 0.0 3.2e-18 66.3 0.0 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 CDF89806.1 - 3.9e-06 26.1 0.0 0.00063 18.9 0.0 2.4 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 CDF89806.1 - 1.2e-05 25.0 0.0 4.1e-05 23.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 CDF89806.1 - 0.002 17.7 0.0 0.0077 15.8 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 CDF89806.1 - 0.032 13.7 0.0 1.3 8.4 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF1822 PF08852.6 CDF89806.1 - 0.054 12.3 1.0 6.5 5.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1822) Cnd1 PF12717.2 CDF89808.1 - 4e-51 173.3 8.4 1.9e-49 167.9 0.2 3.5 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.2 CDF89808.1 - 1.8e-45 154.6 0.8 1.8e-45 154.6 0.6 2.1 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT_2 PF13646.1 CDF89808.1 - 4.8e-10 39.5 0.0 0.0045 17.2 0.0 4.2 3 1 1 4 4 4 2 HEAT repeats HEAT PF02985.17 CDF89808.1 - 1.4e-09 37.2 3.2 0.92 9.7 0.0 6.1 5 0 0 5 5 5 4 HEAT repeat HEAT_EZ PF13513.1 CDF89808.1 - 5.1e-05 23.6 2.5 1.2 9.7 0.0 5.3 4 2 2 6 6 6 3 HEAT-like repeat Cnd3 PF12719.2 CDF89808.1 - 0.00031 19.8 0.6 0.00031 19.8 0.4 2.8 2 1 1 3 3 3 1 Nuclear condensing complex subunits, C-term domain Ferrochelatase PF00762.14 CDF89809.1 - 5.4e-90 301.5 0.0 6.3e-90 301.3 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase MBOAT PF03062.14 CDF89810.1 - 2.6e-60 204.2 13.5 2.6e-60 204.2 9.4 1.9 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family DUF998 PF06197.8 CDF89810.1 - 0.0095 15.2 1.3 0.5 9.6 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF998) Med4 PF10018.4 CDF89811.1 - 3.3e-41 140.7 4.9 5.2e-41 140.1 3.4 1.3 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 DUF950 PF06106.6 CDF89811.1 - 0.056 13.5 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Staphylococcus protein of unknown function (DUF950) NPV_P10 PF05531.7 CDF89811.1 - 0.071 13.3 0.6 2.3 8.4 0.4 2.5 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Reo_sigmaC PF04582.7 CDF89811.1 - 0.13 11.3 0.2 0.18 10.9 0.1 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein TBPIP PF07106.8 CDF89811.1 - 8.6 5.8 11.9 0.38 10.2 3.0 2.4 2 1 1 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF4187 PF13821.1 CDF89812.1 - 7.6e-16 57.4 3.5 1.9e-15 56.1 2.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.18 CDF89812.1 - 0.00056 19.6 0.3 0.0025 17.5 0.0 2.2 2 0 0 2 2 2 1 G-patch domain zf-C2H2_jaz PF12171.3 CDF89812.1 - 0.033 14.3 2.1 0.067 13.3 1.4 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CDF89812.1 - 0.12 12.5 0.8 0.24 11.6 0.6 1.5 1 0 0 1 1 1 0 Zinc-finger of C2H2 type DcpS PF05652.7 CDF89813.1 - 3.7e-38 130.3 0.0 6e-38 129.6 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C PF11969.3 CDF89813.1 - 2.3e-32 111.6 0.0 4.8e-32 110.6 0.0 1.6 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DUF1293 PF06950.6 CDF89813.1 - 0.13 12.1 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1293) Na_H_Exchanger PF00999.16 CDF89815.1 - 5.3e-75 252.3 28.7 7e-75 251.9 19.9 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Nha1_C PF08619.5 CDF89815.1 - 7.9e-24 84.7 0.4 1.1e-23 84.2 0.3 1.2 1 0 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus YrhC PF14143.1 CDF89815.1 - 0.17 11.8 0.9 0.68 9.9 0.1 2.5 2 0 0 2 2 2 0 YrhC-like protein Zn_clus PF00172.13 CDF89816.1 - 8e-07 28.8 10.2 1.7e-06 27.7 7.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3417 PF11897.3 CDF89816.1 - 0.1 12.5 1.6 1.7 8.6 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3417) p450 PF00067.17 CDF89817.1 - 2.8e-105 352.5 0.0 3.3e-105 352.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3020 PF11223.3 CDF89818.1 - 5.6e-13 49.0 10.8 5.6e-13 49.0 7.5 8.0 7 1 0 7 7 7 1 Protein of unknown function (DUF3020) zf-C2H2 PF00096.21 CDF89819.1 - 1.2e-05 25.3 11.8 0.00068 19.8 1.8 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CDF89819.1 - 0.00075 19.6 12.1 0.0091 16.2 0.7 3.6 3 0 0 3 3 3 1 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CDF89819.1 - 0.014 15.6 14.2 0.06 13.6 0.5 4.4 4 0 0 4 4 4 0 Zinc-finger double domain PyrI_C PF02748.10 CDF89819.1 - 0.031 13.7 0.5 0.16 11.4 0.1 2.3 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DUF1203 PF06718.6 CDF89819.1 - 0.065 13.0 0.0 0.24 11.2 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1203) zf-BED PF02892.10 CDF89819.1 - 0.24 11.1 6.1 0.1 12.3 0.4 2.7 3 0 0 3 3 3 0 BED zinc finger TPT PF03151.11 CDF89820.1 - 1.1e-35 122.5 0.2 1.1e-35 122.5 0.1 2.2 2 0 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.6 CDF89820.1 - 3e-11 42.8 13.6 3.9e-09 35.8 3.8 2.1 2 0 0 2 2 2 2 UAA transporter family EamA PF00892.15 CDF89820.1 - 0.00039 20.4 21.0 0.0022 18.0 5.5 3.1 2 2 0 2 2 2 2 EamA-like transporter family DUF914 PF06027.7 CDF89820.1 - 0.00047 19.1 4.0 0.0021 16.9 0.9 2.1 2 0 0 2 2 2 1 Eukaryotic protein of unknown function (DUF914) EmrE PF13536.1 CDF89820.1 - 0.014 15.6 5.3 0.014 15.6 3.7 2.9 2 1 0 2 2 2 0 Multidrug resistance efflux transporter UPF0546 PF10639.4 CDF89820.1 - 0.11 12.3 6.6 3 7.6 1.0 2.8 3 0 0 3 3 3 0 Uncharacterised protein family UPF0546 DUF485 PF04341.7 CDF89820.1 - 1.6 8.5 8.9 2.8 7.7 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function, DUF485 MRP-L28 PF09812.4 CDF89821.1 - 4.4e-37 127.3 2.8 5.3e-37 127.0 1.9 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 UQ_con PF00179.21 CDF89821.1 - 0.04 13.3 0.2 0.065 12.6 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme CGI-121 PF08617.5 CDF89823.1 - 8.3e-32 110.0 0.0 9.9e-32 109.8 0.0 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 MAT1 PF06391.8 CDF89824.1 - 9.6e-61 204.8 22.0 1.1e-60 204.6 15.3 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_2 PF13923.1 CDF89824.1 - 0.0013 18.7 4.8 0.0028 17.6 3.4 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDF89824.1 - 0.0014 18.2 2.7 0.0037 16.8 1.9 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DNA_topoisoIV PF00521.15 CDF89824.1 - 0.0062 15.4 4.1 0.0089 14.9 2.9 1.3 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A zf-C3HC4_3 PF13920.1 CDF89824.1 - 0.018 14.7 5.0 0.032 13.9 3.5 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDF89824.1 - 0.018 14.7 5.5 0.038 13.7 3.8 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.1 CDF89824.1 - 0.029 14.1 5.9 0.054 13.3 4.1 1.5 1 0 0 1 1 1 0 Ring finger domain 3HCDH_N PF02737.13 CDF89824.1 - 0.1 12.2 1.8 0.16 11.6 1.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain zf-RING_UBOX PF13445.1 CDF89824.1 - 0.33 10.7 4.0 0.79 9.4 2.8 1.7 1 0 0 1 1 1 0 RING-type zinc-finger Mitovir_RNA_pol PF05919.6 CDF89824.1 - 0.53 9.1 5.6 0.65 8.8 3.9 1.1 1 0 0 1 1 1 0 Mitovirus RNA-dependent RNA polymerase Exonuc_VII_L PF02601.10 CDF89824.1 - 0.71 9.0 6.8 1 8.5 4.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit APG6 PF04111.7 CDF89824.1 - 1 8.3 13.6 1.5 7.7 9.5 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 zf-RING_4 PF14570.1 CDF89824.1 - 1 9.0 7.9 2.9 7.5 5.5 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain A_deaminase PF00962.17 CDF89825.1 - 9.9e-119 396.1 0.3 1.6e-118 395.3 0.2 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase MSC PF09402.5 CDF89826.1 - 5.8e-100 334.2 5.9 5.8e-100 334.2 4.1 2.4 1 1 0 2 2 2 1 Man1-Src1p-C-terminal domain HeH PF12949.2 CDF89826.1 - 1.3e-15 56.5 1.5 3e-15 55.4 0.2 2.4 2 0 0 2 2 2 1 HeH/LEM domain HECT PF00632.20 CDF89827.1 - 7.5e-94 314.4 0.7 1e-92 310.7 0.1 2.8 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) DUF908 PF06012.7 CDF89827.1 - 1.8e-78 264.1 2.3 1.8e-78 264.1 1.6 2.5 2 0 0 2 2 2 1 Domain of Unknown Function (DUF908) DUF913 PF06025.7 CDF89827.1 - 3.6e-45 154.3 0.1 1.4e-44 152.4 0.0 2.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) DUF4414 PF14377.1 CDF89827.1 - 2.1e-16 59.7 4.5 8.8e-16 57.7 3.1 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4414) Rad52_Rad22 PF04098.10 CDF89828.1 - 1e-56 190.9 0.0 1.4e-56 190.4 0.0 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein Ndc1_Nup PF09531.5 CDF89829.1 - 1.9e-121 406.4 21.3 8.9e-121 404.2 14.7 1.8 1 1 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Na_H_Exchanger PF00999.16 CDF89830.1 - 1.4e-61 208.1 36.6 1.9e-61 207.7 25.4 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Myc_target_1 PF15179.1 CDF89830.1 - 0.28 10.7 7.2 0.058 12.9 0.5 2.8 3 0 0 3 3 3 0 Myc target protein 1 EVC2_like PF12297.3 CDF89830.1 - 3.8 6.0 5.5 2.8 6.4 1.0 2.1 1 1 1 2 2 2 0 Ellis van Creveld protein 2 like protein Guanylate_kin PF00625.16 CDF89831.1 - 1.6e-70 236.3 0.0 1.7e-70 236.1 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.1 CDF89831.1 - 6e-08 32.6 0.0 1.9e-07 31.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CDF89831.1 - 5.1e-07 29.8 0.1 1.6e-05 25.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CDF89831.1 - 7.8e-07 29.2 0.2 2.6e-06 27.5 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 CDF89831.1 - 9.4e-06 26.4 0.2 2.8e-05 24.9 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CDF89831.1 - 1.4e-05 25.3 0.1 4e-05 23.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 CDF89831.1 - 7.3e-05 22.7 0.1 0.0015 18.5 0.1 2.1 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 CDF89831.1 - 0.00016 21.6 0.0 0.00059 19.7 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_14 PF13173.1 CDF89831.1 - 0.0002 21.2 0.0 0.00035 20.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.22 CDF89831.1 - 0.00024 21.4 0.1 0.00036 20.8 0.0 1.7 1 1 0 1 1 1 1 ABC transporter Arch_ATPase PF01637.13 CDF89831.1 - 0.00026 20.7 0.3 0.00034 20.3 0.2 1.6 1 1 0 1 1 1 1 Archaeal ATPase RNA_helicase PF00910.17 CDF89831.1 - 0.00036 20.6 0.0 0.00072 19.7 0.0 1.5 1 1 0 1 1 1 1 RNA helicase AAA_24 PF13479.1 CDF89831.1 - 0.00078 19.0 0.8 0.0013 18.3 0.5 1.7 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 CDF89831.1 - 0.00079 18.6 0.0 0.0014 17.8 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function, DUF258 AAA PF00004.24 CDF89831.1 - 0.0011 19.1 0.6 0.01 16.0 0.4 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 CDF89831.1 - 0.0017 17.7 0.3 0.012 15.0 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_21 PF13304.1 CDF89831.1 - 0.0021 18.0 0.0 0.0029 17.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 CDF89831.1 - 0.0025 17.5 0.0 0.0068 16.0 0.0 1.7 2 0 0 2 2 2 1 NACHT domain AAA_23 PF13476.1 CDF89831.1 - 0.0031 17.8 3.0 0.014 15.7 2.1 2.0 1 1 0 1 1 1 1 AAA domain Miro PF08477.8 CDF89831.1 - 0.0033 17.8 0.0 0.006 17.0 0.0 1.6 1 1 0 1 1 1 1 Miro-like protein AAA_10 PF12846.2 CDF89831.1 - 0.0041 16.5 0.0 0.0085 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA-like domain DUF2075 PF09848.4 CDF89831.1 - 0.0056 15.7 0.0 0.022 13.7 0.0 1.8 1 1 1 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_29 PF13555.1 CDF89831.1 - 0.011 15.2 0.9 0.033 13.7 0.1 2.2 2 1 0 2 2 2 0 P-loop containing region of AAA domain KAP_NTPase PF07693.9 CDF89831.1 - 0.011 14.7 0.2 0.019 13.9 0.1 1.6 1 1 0 1 1 1 0 KAP family P-loop domain AAA_19 PF13245.1 CDF89831.1 - 0.014 15.0 0.0 0.03 14.0 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain MobB PF03205.9 CDF89831.1 - 0.04 13.6 0.0 0.1 12.3 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B DUF1895 PF08988.5 CDF89831.1 - 0.043 13.8 0.2 0.11 12.4 0.0 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF1895) AAA_30 PF13604.1 CDF89831.1 - 0.043 13.3 0.0 0.088 12.3 0.0 1.5 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.17 CDF89831.1 - 0.054 12.3 0.0 0.1 11.4 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain cobW PF02492.14 CDF89831.1 - 0.058 12.8 0.0 0.37 10.2 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.9 CDF89831.1 - 0.063 13.0 0.1 0.34 10.6 0.0 2.2 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Thymidylate_kin PF02223.12 CDF89831.1 - 0.066 12.5 0.3 3.3 7.0 0.0 2.1 1 1 1 2 2 2 0 Thymidylate kinase T2SE PF00437.15 CDF89831.1 - 0.074 11.9 0.0 0.16 10.8 0.0 1.5 2 0 0 2 2 2 0 Type II/IV secretion system protein Rad17 PF03215.10 CDF89831.1 - 0.097 11.3 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein NTPase_1 PF03266.10 CDF89831.1 - 0.11 12.2 0.1 0.19 11.4 0.0 1.6 1 1 0 1 1 1 0 NTPase HIG_1_N PF04588.8 CDF89832.1 - 4.3e-20 71.1 3.0 5.8e-20 70.7 2.1 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region DUF3995 PF13160.1 CDF89832.1 - 0.0092 16.0 0.0 0.011 15.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3995) DUF4407 PF14362.1 CDF89832.1 - 0.015 14.2 4.2 0.024 13.5 2.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CD20 PF04103.10 CDF89832.1 - 0.038 13.9 0.0 0.049 13.5 0.0 1.1 1 0 0 1 1 1 0 CD20-like family AAA_23 PF13476.1 CDF89832.1 - 0.21 11.8 6.7 0.25 11.6 4.6 1.1 1 0 0 1 1 1 0 AAA domain Herpes_UL25 PF01499.11 CDF89832.1 - 2.8 6.1 10.2 3.4 5.8 7.1 1.1 1 0 0 1 1 1 0 Herpesvirus UL25 family Bap31 PF05529.7 CDF89832.1 - 3.1 7.2 7.8 4.1 6.8 5.4 1.2 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like DUF4231 PF14015.1 CDF89832.1 - 4 7.4 6.3 27 4.7 4.3 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF4231) TMPIT PF07851.8 CDF89832.1 - 6.1 5.8 8.5 4.4 6.2 0.1 2.1 1 1 1 2 2 2 0 TMPIT-like protein DUF4140 PF13600.1 CDF89832.1 - 6.5 7.2 8.4 22 5.5 5.8 2.0 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) AhpC-TSA PF00578.16 CDF89833.1 - 3.2e-35 120.4 0.0 2e-34 117.9 0.0 1.9 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.5 CDF89833.1 - 3.1e-18 65.7 0.1 4.7e-18 65.1 0.0 1.3 2 0 0 2 2 2 1 Redoxin 1-cysPrx_C PF10417.4 CDF89833.1 - 1.6e-11 43.6 0.3 3e-11 42.7 0.2 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Metallophos PF00149.23 CDF89834.1 - 1.2e-10 41.1 1.8 1.3e-09 37.7 1.2 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase RNA_pol_Rpb1_1 PF04997.7 CDF89834.1 - 0.053 12.7 2.3 0.086 12.0 1.6 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 1 Peptidase_S49_N PF08496.5 CDF89834.1 - 0.2 11.4 5.3 0.5 10.1 0.9 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal NST1 PF13945.1 CDF89834.1 - 2.7 8.0 12.4 0.19 11.7 1.9 2.3 2 0 0 2 2 2 0 Salt tolerance down-regulator Homeobox PF00046.24 CDF89835.1 - 5.9e-18 64.2 5.5 1.1e-17 63.3 3.8 1.4 1 0 0 1 1 1 1 Homeobox domain Homeobox_KN PF05920.6 CDF89835.1 - 0.0013 18.3 1.6 0.013 15.1 0.2 2.5 2 0 0 2 2 2 1 Homeobox KN domain CMV_1a PF12467.3 CDF89835.1 - 0.65 10.3 10.1 0.058 13.7 3.5 1.7 2 0 0 2 2 2 0 Cucumber mosaic virus 1a protein family Ribosomal_S13 PF00416.17 CDF89836.1 - 5.6e-42 142.5 2.3 6.5e-42 142.3 1.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.6 CDF89836.1 - 0.0006 18.4 0.0 0.0009 17.8 0.0 1.2 1 1 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) HHH_6 PF14579.1 CDF89836.1 - 0.077 13.0 0.2 0.59 10.2 0.1 2.3 2 1 0 2 2 2 0 Helix-hairpin-helix motif PP28 PF10252.4 CDF89836.1 - 0.083 12.9 0.5 0.19 11.7 0.3 1.6 1 0 0 1 1 1 0 Casein kinase substrate phosphoprotein PP28 Ribosomal_L4 PF00573.17 CDF89837.1 - 1.7e-47 161.2 0.0 2e-47 161.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family U3_assoc_6 PF08640.6 CDF89838.1 - 2e-34 117.2 4.5 4e-32 109.8 0.6 3.0 3 0 0 3 3 3 2 U3 small nucleolar RNA-associated protein 6 NRDE-2 PF08424.5 CDF89838.1 - 1.3e-06 27.5 3.2 2.4e-06 26.6 0.6 2.1 1 1 1 2 2 2 2 NRDE-2, necessary for RNA interference TPR_14 PF13428.1 CDF89838.1 - 0.0075 16.8 0.0 1.7 9.5 0.0 3.1 1 1 2 3 3 3 1 Tetratricopeptide repeat DUF2250 PF10007.4 CDF89838.1 - 0.0079 16.0 0.3 1.5 8.7 0.0 3.5 4 0 0 4 4 4 1 Uncharacterized protein conserved in archaea (DUF2250) Suf PF05843.9 CDF89838.1 - 0.12 12.0 8.1 0.12 12.0 1.1 3.6 3 1 1 4 4 4 0 Suppressor of forked protein (Suf) HAT PF02184.11 CDF89838.1 - 0.3 10.8 2.2 0.6 9.8 0.0 2.5 3 0 0 3 3 3 0 HAT (Half-A-TPR) repeat ZZ PF00569.12 CDF89839.1 - 1.7e-15 56.2 9.7 2.9e-15 55.5 6.7 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type SWIRM PF04433.12 CDF89839.1 - 2e-13 50.2 0.2 1.9e-10 40.6 0.0 2.8 2 0 0 2 2 2 2 SWIRM domain Myb_DNA-binding PF00249.26 CDF89839.1 - 1.1e-06 28.5 0.0 2.6e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CDF89839.1 - 0.0015 18.5 0.0 0.005 16.9 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Enterotoxin_b PF01376.13 CDF89839.1 - 0.012 15.4 0.1 2.2 8.1 0.0 2.6 2 0 0 2 2 2 0 Heat-labile enterotoxin beta chain Ribosomal_S17e PF00833.13 CDF89840.1 - 1.7e-56 189.2 0.3 2e-56 188.9 0.2 1.1 1 0 0 1 1 1 1 Ribosomal S17 Phage_lysis PF03245.8 CDF89840.1 - 0.087 12.8 0.6 2.3 8.2 0.0 2.1 1 1 0 2 2 2 0 Bacteriophage Rz lysis protein PemK PF02452.12 CDF89840.1 - 0.11 12.6 0.1 0.19 11.9 0.1 1.4 1 0 0 1 1 1 0 PemK-like protein ECM11 PF15463.1 CDF89841.1 - 3.5e-25 88.8 5.2 6.7e-25 87.9 0.2 2.4 2 1 1 3 3 3 2 Extracellular mutant protein 11 FAD-oxidase_C PF02913.14 CDF89842.1 - 2e-47 161.6 0.0 2.8e-47 161.1 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 CDF89842.1 - 3.2e-32 110.9 0.2 7.4e-32 109.7 0.1 1.7 1 0 0 1 1 1 1 FAD binding domain DUF676 PF05057.9 CDF89843.1 - 3.9e-43 147.2 0.0 6.1e-43 146.6 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF915 PF06028.6 CDF89843.1 - 0.0001 21.5 0.0 0.00017 20.7 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Lipase_3 PF01764.20 CDF89843.1 - 0.0011 18.6 0.0 0.0021 17.7 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.2 CDF89843.1 - 0.1 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Sugar_tr PF00083.19 CDF89844.1 - 2.6e-166 553.6 31.5 3.1e-166 553.4 21.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CDF89844.1 - 2.2e-33 115.4 32.3 1.5e-32 112.7 16.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Cytochrom_B_N PF00033.14 CDF89844.1 - 0.025 13.9 9.8 0.04 13.2 2.9 3.3 3 1 0 3 3 3 0 Cytochrome b(N-terminal)/b6/petB Ni_hydr_CYTB PF01292.15 CDF89844.1 - 0.11 11.9 10.1 0.41 9.9 1.7 3.4 3 1 1 4 4 4 0 Prokaryotic cytochrome b561 GSHPx PF00255.14 CDF89845.1 - 3.6e-45 151.7 0.0 4.5e-45 151.4 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.16 CDF89845.1 - 6.1e-05 22.7 0.0 0.00021 20.9 0.0 1.8 1 1 1 2 2 2 1 AhpC/TSA family Redoxin PF08534.5 CDF89845.1 - 0.00052 19.5 0.0 0.0017 17.9 0.0 1.9 1 1 0 1 1 1 1 Redoxin Aminotran_1_2 PF00155.16 CDF89845.1 - 0.13 11.1 0.0 0.19 10.6 0.0 1.1 1 0 0 1 1 1 0 Aminotransferase class I and II Med13_C PF06333.7 CDF89846.1 - 4.9e-88 295.4 0.1 2.8e-55 187.5 0.0 2.4 1 1 1 2 2 2 2 Mediator complex subunit 13 C-terminal Nse5 PF08691.5 CDF89847.1 - 1e-118 397.0 2.6 1.2e-118 396.7 1.8 1.0 1 0 0 1 1 1 1 DNA repair proteins Nse5 and Nse6 Pribosyltran PF00156.22 CDF89848.1 - 6.4e-17 61.4 0.0 8.8e-17 60.9 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 CDF89848.1 - 0.00085 18.5 0.0 0.0012 18.0 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase MoCF_biosynth PF00994.19 CDF89848.1 - 0.021 14.2 0.0 0.033 13.5 0.0 1.3 1 0 0 1 1 1 0 Probable molybdopterin binding domain DOT1 PF08123.8 CDF89849.1 - 2.5e-86 288.2 0.0 3.6e-86 287.7 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 UDG PF03167.14 CDF89850.1 - 7.1e-26 90.5 0.0 1.1e-25 89.8 0.0 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily LRS4 PF10422.4 CDF89852.1 - 1.4e-19 70.4 21.4 5.3e-18 65.2 14.8 2.8 1 1 0 1 1 1 1 Monopolin complex subunit LRS4 Dsl1_C PF11989.3 CDF89852.1 - 0.00083 18.6 1.3 0.00083 18.6 0.9 1.7 2 0 0 2 2 2 1 Retrograde transport protein Dsl1 C terminal TPR_MLP1_2 PF07926.7 CDF89852.1 - 0.0032 17.2 6.3 0.0032 17.2 4.4 1.6 2 0 0 2 2 2 1 TPR/MLP1/MLP2-like protein FlxA PF14282.1 CDF89852.1 - 0.0041 17.0 5.7 0.0041 17.0 4.0 1.9 2 0 0 2 2 2 1 FlxA-like protein DUF3573 PF12097.3 CDF89852.1 - 0.013 14.1 0.5 0.016 13.8 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) IncA PF04156.9 CDF89852.1 - 0.098 12.2 4.8 0.18 11.3 3.3 1.5 1 0 0 1 1 1 0 IncA protein bZIP_1 PF00170.16 CDF89852.1 - 0.26 11.2 7.2 18 5.3 5.0 2.7 1 1 0 1 1 1 0 bZIP transcription factor DUF106 PF01956.11 CDF89852.1 - 0.47 9.9 1.7 0.81 9.1 1.2 1.4 1 0 0 1 1 1 0 Integral membrane protein DUF106 HALZ PF02183.13 CDF89852.1 - 0.72 9.6 6.7 0.28 10.9 1.7 2.3 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF972 PF06156.8 CDF89852.1 - 0.99 9.7 9.8 0.19 12.0 3.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF972) TMPIT PF07851.8 CDF89852.1 - 2.4 7.1 5.2 4.4 6.2 3.6 1.3 1 0 0 1 1 1 0 TMPIT-like protein DivIC PF04977.10 CDF89852.1 - 6.6 6.2 8.0 55 3.3 4.8 2.4 1 1 1 2 2 2 0 Septum formation initiator bZIP_2 PF07716.10 CDF89852.1 - 9.1 6.1 12.7 0.76 9.6 1.4 2.8 1 1 1 2 2 2 0 Basic region leucine zipper Uso1_p115_C PF04871.8 CDF89852.1 - 9.9 6.0 12.8 1 9.2 5.6 1.7 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region JmjN PF02375.12 CDF89853.1 - 0.061 12.8 0.1 0.3 10.6 0.0 2.1 2 0 0 2 2 2 0 jmjN domain PIG-P PF08510.7 CDF89854.1 - 5.3e-33 113.3 1.3 6.2e-33 113.1 0.9 1.1 1 0 0 1 1 1 1 PIG-P MFS_2 PF13347.1 CDF89854.1 - 0.0038 15.6 0.1 0.0044 15.4 0.1 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein DUF4131 PF13567.1 CDF89854.1 - 0.085 12.2 0.0 0.1 12.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Metallophos PF00149.23 CDF89855.1 - 1.6e-39 135.3 0.2 3.6e-39 134.2 0.2 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase LCM PF04072.9 CDF89856.1 - 1.5e-19 70.2 0.0 1.9e-19 69.9 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase TAFII28 PF04719.9 CDF89857.1 - 2.1e-26 91.5 0.9 6.4e-25 86.7 0.4 2.4 2 0 0 2 2 2 2 hTAFII28-like protein conserved region PIG-S PF10510.4 CDF89858.1 - 2.1e-136 455.6 4.7 2.5e-136 455.3 3.2 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein Methyltransf_11 PF08241.7 CDF89859.1 - 1.1e-10 41.8 0.2 2.1e-10 40.9 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDF89859.1 - 4.6e-06 26.2 0.0 8.9e-06 25.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDF89859.1 - 2.5e-05 24.0 0.0 6.1e-05 22.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDF89859.1 - 5.6e-05 23.5 0.4 0.0002 21.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDF89859.1 - 0.0002 21.6 0.3 0.00067 19.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDF89859.1 - 0.022 15.3 0.7 0.052 14.1 0.1 1.9 2 1 0 2 2 2 0 Methyltransferase domain UBA_4 PF14555.1 CDF89860.1 - 2.7e-10 39.6 0.1 9.4e-10 37.8 0.0 1.9 2 0 0 2 2 2 1 UBA-like domain UBX PF00789.15 CDF89860.1 - 9.2e-10 38.4 0.0 3.8e-09 36.4 0.0 2.1 2 1 0 2 2 2 1 UBX domain DnaI_N PF07319.6 CDF89860.1 - 0.26 11.5 0.1 0.26 11.5 0.0 1.9 2 0 0 2 2 2 0 Primosomal protein DnaI N-terminus RRM_1 PF00076.17 CDF89861.1 - 5.2e-29 99.6 0.8 8e-17 60.6 0.3 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF89861.1 - 3.9e-17 61.9 0.1 8.5e-12 44.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF89861.1 - 6e-12 45.2 0.1 2.5e-10 40.0 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 CDF89861.1 - 0.021 14.5 0.0 4.7 7.0 0.0 2.3 2 0 0 2 2 2 0 Limkain b1 RNA_bind PF08675.6 CDF89861.1 - 0.097 12.6 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 RNA binding domain CYSTM PF12734.2 CDF89861.1 - 0.98 9.5 3.2 3.6 7.7 2.2 2.0 1 0 0 1 1 1 0 Cysteine-rich TM module stress tolerance M16C_assoc PF08367.6 CDF89862.1 - 1e-76 257.1 0.0 1.5e-76 256.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.16 CDF89862.1 - 2.3e-26 92.6 0.1 9.9e-17 61.1 0.0 2.9 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 CDF89862.1 - 6.4e-08 32.4 0.0 4.2e-07 29.8 0.0 2.2 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) EMP24_GP25L PF01105.19 CDF89863.1 - 2.6e-42 144.5 0.0 3e-42 144.4 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD EzrA PF06160.7 CDF89863.1 - 0.0035 15.6 0.3 0.0042 15.3 0.2 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Rad33 PF08730.5 CDF89864.1 - 2e-39 134.7 2.2 1.2e-23 83.4 0.1 2.1 1 1 1 2 2 2 2 Rad33 NPR3 PF03666.8 CDF89864.1 - 0.096 11.2 0.1 0.11 10.9 0.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Spt5-NGN PF03439.8 CDF89865.1 - 4.9e-22 77.4 0.0 1.2e-21 76.2 0.0 1.7 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.3 CDF89865.1 - 8.5e-18 64.7 14.7 8.5e-18 64.7 10.2 3.5 2 1 1 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal KOW PF00467.24 CDF89865.1 - 7.3e-13 47.6 13.8 0.0083 15.8 0.3 4.9 4 0 0 4 4 4 4 KOW motif DUF4438 PF14505.1 CDF89865.1 - 0.0088 14.8 0.5 0.53 9.0 0.0 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF4438) Nucleo_P87 PF07267.6 CDF89865.1 - 5 5.6 22.9 12 4.4 15.9 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Ribosomal_L33 PF00471.15 CDF89866.1 - 0.0012 19.0 0.0 0.013 15.7 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein L33 eIF3g PF12353.3 CDF89867.1 - 2.3e-44 150.3 3.4 3.2e-44 149.9 2.4 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.17 CDF89867.1 - 1.7e-10 40.3 0.0 2.9e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF89867.1 - 5.8e-07 29.4 0.0 1e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF89867.1 - 9.6e-05 22.1 0.0 0.00018 21.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Abhydrolase_6 PF12697.2 CDF89868.1 - 1.8e-10 41.1 0.1 1.8e-09 37.7 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 CDF89868.1 - 2.7e-10 40.1 0.0 3.5e-10 39.8 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CDF89868.1 - 4.9e-09 36.0 0.0 6.4e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDF89868.1 - 8.6e-07 28.7 0.0 2.1e-06 27.4 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Thioesterase PF00975.15 CDF89868.1 - 0.00093 19.4 0.0 0.0017 18.5 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Lipase_3 PF01764.20 CDF89868.1 - 0.025 14.1 0.0 0.052 13.1 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) DUF2305 PF10230.4 CDF89868.1 - 0.062 12.6 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) DUF900 PF05990.7 CDF89868.1 - 0.12 11.7 0.2 4 6.6 0.0 2.3 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) PCI PF01399.22 CDF89869.1 - 2.2e-15 56.8 0.1 7.6e-15 55.1 0.0 2.0 2 0 0 2 2 2 1 PCI domain SLS PF14611.1 CDF89869.1 - 0.0033 16.8 0.7 0.0062 15.9 0.5 1.4 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator Spo0A_C PF08769.6 CDF89869.1 - 0.0049 16.7 0.0 0.014 15.2 0.0 1.7 2 0 0 2 2 2 1 Sporulation initiation factor Spo0A C terminal PCI_Csn8 PF10075.4 CDF89869.1 - 0.0077 16.0 1.2 0.12 12.1 0.0 2.6 3 0 0 3 3 3 1 COP9 signalosome, subunit CSN8 ELF PF03317.8 CDF89869.1 - 0.022 14.0 0.2 0.041 13.1 0.1 1.4 1 0 0 1 1 1 0 ELF protein PX PF00787.19 CDF89870.1 - 1.9e-13 50.2 0.0 6.1e-13 48.5 0.0 1.9 1 0 0 1 1 1 1 PX domain Dynein_light PF01221.13 CDF89871.1 - 2e-33 114.1 0.0 2.3e-33 114.0 0.0 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Ground-like PF04155.13 CDF89871.1 - 0.039 14.2 0.0 0.052 13.8 0.0 1.1 1 0 0 1 1 1 0 Ground-like domain Kinesin PF00225.18 CDF89872.1 - 7.1e-101 337.2 1.6 1.3e-100 336.3 1.1 1.4 1 0 0 1 1 1 1 Kinesin motor domain Las1 PF04031.8 CDF89872.1 - 0.019 14.6 0.5 0.043 13.4 0.0 1.9 2 0 0 2 2 2 0 Las1-like Sugar_tr PF00083.19 CDF89873.1 - 1.7e-27 96.1 31.1 2e-19 69.5 7.6 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.11 CDF89873.1 - 3.6e-15 55.5 52.4 7.2e-14 51.2 24.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2890 PF11081.3 CDF89873.1 - 0.31 11.0 7.8 0.61 10.1 5.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Transgly_assoc PF04226.8 CDF89873.1 - 0.62 10.1 0.1 0.62 10.1 0.0 5.1 4 1 1 5 5 5 0 Transglycosylase associated protein Sterol_MT_C PF08498.5 CDF89874.1 - 5.3e-29 99.9 1.3 8.2e-29 99.3 0.9 1.3 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.7 CDF89874.1 - 8.7e-21 74.2 0.0 1.7e-20 73.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDF89874.1 - 1.2e-18 67.1 0.0 1.9e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDF89874.1 - 2.2e-14 53.5 0.0 4e-14 52.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 CDF89874.1 - 3e-13 49.4 0.3 4.1e-13 49.0 0.2 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.2 CDF89874.1 - 6.9e-13 49.1 0.0 1.6e-12 47.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDF89874.1 - 1.7e-12 47.5 0.0 3.6e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDF89874.1 - 1.2e-10 41.7 0.0 4e-10 40.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 CDF89874.1 - 4.2e-10 39.1 0.0 6.2e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 CDF89874.1 - 2e-09 37.5 0.0 5.1e-09 36.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.5 CDF89874.1 - 8.2e-08 31.9 0.0 1.4e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.8 CDF89874.1 - 9.8e-06 24.8 0.0 2.5e-05 23.5 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.13 CDF89874.1 - 5.4e-05 22.8 0.0 9.5e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 PCMT PF01135.14 CDF89874.1 - 0.00016 21.2 0.0 0.00029 20.4 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.9 CDF89874.1 - 0.00034 20.0 0.0 0.00068 19.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain RrnaAD PF00398.15 CDF89874.1 - 0.0033 16.4 0.0 0.0048 15.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Met_10 PF02475.11 CDF89874.1 - 0.006 16.1 0.0 0.017 14.7 0.0 1.6 2 0 0 2 2 2 1 Met-10+ like-protein N6_N4_Mtase PF01555.13 CDF89874.1 - 0.036 13.5 0.1 2.3 7.6 0.0 2.4 2 1 0 2 2 2 0 DNA methylase Methyltransf_2 PF00891.13 CDF89874.1 - 0.038 13.1 0.0 0.095 11.8 0.0 1.6 1 1 0 1 1 1 0 O-methyltransferase Methyltransf_32 PF13679.1 CDF89874.1 - 0.052 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain HSP20 PF00011.16 CDF89875.1 - 6.8e-21 74.0 1.6 6.8e-21 74.0 1.1 1.4 2 0 0 2 2 2 1 Hsp20/alpha crystallin family YebF PF13995.1 CDF89875.1 - 0.11 12.4 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 YebF-like protein BLOC1_2 PF10046.4 CDF89876.1 - 0.0047 17.0 1.7 0.0047 17.0 1.1 2.9 3 1 0 3 3 3 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF972 PF06156.8 CDF89876.1 - 3.7 7.9 19.5 5.1 7.4 0.6 4.1 2 1 2 4 4 4 0 Protein of unknown function (DUF972) PAP1 PF08601.5 CDF89877.1 - 2e-50 172.4 20.2 1.4e-42 146.6 6.0 3.4 1 1 2 3 3 3 2 Transcription factor PAP1 bZIP_1 PF00170.16 CDF89877.1 - 2.8e-08 33.5 9.9 7.3e-08 32.2 6.9 1.8 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 CDF89877.1 - 2.1e-05 24.2 10.4 2.1e-05 24.2 7.2 2.1 2 0 0 2 2 2 1 Basic region leucine zipper MscS_TM PF12794.2 CDF89877.1 - 2.8 6.4 3.6 4.7 5.7 2.5 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 AMPKBI PF04739.10 CDF89878.1 - 6.7e-28 96.5 2.2 1.5e-27 95.3 0.2 2.4 2 0 0 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interation domain Sterile PF03015.14 CDF89879.1 - 0.12 12.6 0.1 0.26 11.5 0.1 1.5 1 0 0 1 1 1 0 Male sterility protein Zn_clus PF00172.13 CDF89880.1 - 4.1e-06 26.5 11.3 1e-05 25.3 7.8 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain IMS PF00817.15 CDF89882.1 - 7.1e-45 152.4 0.0 1.7e-44 151.2 0.0 1.6 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.3 CDF89882.1 - 2.4e-09 37.2 0.2 8.2e-09 35.4 0.1 2.0 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.3 CDF89882.1 - 0.031 14.3 0.0 0.16 12.0 0.0 2.2 2 0 0 2 2 2 0 IMS family HHH motif zf-C2H2 PF00096.21 CDF89882.1 - 0.088 13.1 0.3 0.31 11.4 0.2 2.1 1 0 0 1 1 1 0 Zinc finger, C2H2 type Ribosomal_L11_N PF03946.9 CDF89883.1 - 3.3e-17 61.7 0.1 5.3e-17 61.0 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 CDF89883.1 - 6.9e-11 42.1 1.6 7.1e-11 42.0 0.2 1.7 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain Mak10 PF04112.8 CDF89884.1 - 3.1e-44 150.1 0.1 6.4e-44 149.1 0.1 1.6 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase DUF717 PF05338.7 CDF89884.1 - 0.085 12.8 0.5 13 5.7 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF717) AFG1_ATPase PF03969.11 CDF89885.1 - 3.9e-74 249.6 0.0 1.5e-69 234.5 0.0 2.5 2 1 0 2 2 2 2 AFG1-like ATPase AAA_22 PF13401.1 CDF89885.1 - 1.4e-05 25.2 0.0 3.4e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDF89885.1 - 0.00012 22.1 3.2 0.013 15.5 0.2 3.1 2 1 0 2 2 2 1 AAA ATPase domain NACHT PF05729.7 CDF89885.1 - 0.0036 16.9 0.0 0.0063 16.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA PF00004.24 CDF89885.1 - 0.0052 16.9 0.0 0.016 15.4 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CDF89885.1 - 0.021 14.5 0.0 0.39 10.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Arch_ATPase PF01637.13 CDF89885.1 - 0.044 13.4 0.0 0.093 12.4 0.0 1.6 1 1 0 1 1 1 0 Archaeal ATPase RNA_helicase PF00910.17 CDF89885.1 - 0.056 13.6 0.0 0.16 12.1 0.0 1.8 1 0 0 1 1 1 0 RNA helicase TPR_14 PF13428.1 CDF89886.1 - 0.0026 18.2 0.3 3.9 8.3 0.0 5.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.12 CDF89886.1 - 0.0053 16.5 1.7 0.46 10.5 0.1 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 CDF89886.1 - 0.019 14.7 0.2 3.6 7.5 0.0 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 CDF89886.1 - 0.056 13.3 0.0 0.99 9.3 0.0 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat ATP-synt_D PF01813.12 CDF89887.1 - 1.5e-64 217.1 4.0 1.5e-64 217.1 2.8 1.4 2 0 0 2 2 2 1 ATP synthase subunit D Peptidase_M28 PF04389.12 CDF89888.1 - 6.2e-29 101.0 0.0 1.3e-28 99.9 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.23 CDF89888.1 - 9e-07 28.5 0.0 1.2e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.9 CDF89888.1 - 0.018 13.8 0.0 0.04 12.6 0.0 1.5 1 1 0 1 1 1 0 M42 glutamyl aminopeptidase Ribosomal_L2_C PF03947.13 CDF89889.1 - 5.3e-50 168.5 1.4 9.9e-50 167.6 1.0 1.5 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 CDF89889.1 - 6.1e-29 99.8 0.2 6.1e-29 99.8 0.1 2.0 3 0 0 3 3 3 1 Ribosomal Proteins L2, RNA binding domain EXS PF03124.9 CDF89890.1 - 1.3e-48 165.7 21.8 1.9e-48 165.2 15.1 1.1 1 0 0 1 1 1 1 EXS family Nop25 PF09805.4 CDF89891.1 - 4.8e-32 110.8 18.1 4.8e-32 110.8 12.5 1.7 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) YlqD PF11068.3 CDF89891.1 - 0.48 10.4 13.6 0.065 13.2 6.5 1.7 2 0 0 2 2 2 0 YlqD protein XhlA PF10779.4 CDF89891.1 - 6.4 6.7 7.9 22 5.0 5.5 1.9 1 0 0 1 1 1 0 Haemolysin XhlA DER1 PF04511.10 CDF89892.1 - 3.1e-48 163.8 7.5 4e-48 163.5 5.2 1.1 1 0 0 1 1 1 1 Der1-like family Rhomboid PF01694.17 CDF89892.1 - 0.0015 18.5 4.8 0.0023 17.9 3.3 1.2 1 0 0 1 1 1 1 Rhomboid family Cg6151-P PF10233.4 CDF89892.1 - 0.0037 17.2 0.8 0.0097 15.8 0.5 1.7 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P DUF2514 PF10721.4 CDF89892.1 - 0.08 12.6 0.7 0.12 12.0 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) Carn_acyltransf PF00755.15 CDF89893.1 - 3.9e-167 556.9 0.0 4.5e-167 556.7 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase zf-HIT PF04438.11 CDF89894.1 - 0.001 18.6 10.1 0.0018 17.8 7.0 1.3 1 0 0 1 1 1 1 HIT zinc finger DUF4523 PF15023.1 CDF89894.1 - 0.021 14.3 1.2 0.053 13.0 0.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF4523) LsmAD PF06741.8 CDF89894.1 - 0.053 13.6 4.2 0.092 12.8 1.7 2.1 1 1 1 2 2 2 0 LsmAD domain ICMT PF04140.9 CDF89895.1 - 1.2e-29 102.3 1.6 1.4e-29 102.1 0.2 1.7 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.8 CDF89895.1 - 4.2e-12 46.1 3.0 4.2e-12 46.1 2.1 1.8 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.7 CDF89895.1 - 0.00027 20.2 0.7 0.00038 19.8 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) NnrU PF07298.6 CDF89895.1 - 0.0011 18.3 2.0 0.0018 17.6 1.2 1.4 1 1 0 1 1 1 1 NnrU protein DUF3816 PF12822.2 CDF89895.1 - 0.81 9.5 9.9 2.1 8.2 6.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3816) SdpI PF13630.1 CDF89895.1 - 2.2 8.0 7.5 4.6 7.0 0.2 2.8 3 0 0 3 3 3 0 SdpI/YhfL protein family PetL PF05115.9 CDF89895.1 - 7.1 6.6 8.0 11 5.9 2.6 2.9 2 0 0 2 2 2 0 Cytochrome B6-F complex subunit VI (PetL) PINIT PF14324.1 CDF89896.1 - 1.3e-44 151.7 2.6 2.9e-44 150.6 1.8 1.6 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.15 CDF89896.1 - 2.8e-20 71.5 6.4 5.2e-20 70.6 4.5 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger SAP PF02037.22 CDF89896.1 - 1.9e-10 39.9 0.1 4.5e-10 38.7 0.0 1.7 1 0 0 1 1 1 1 SAP domain zf-Nse PF11789.3 CDF89896.1 - 2.6e-05 23.6 1.2 5.5e-05 22.5 0.8 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 CDF89896.1 - 0.025 14.2 1.5 0.083 12.6 1.1 2.0 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.1 CDF89896.1 - 0.19 11.7 3.4 0.36 10.8 2.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CDF89896.1 - 0.68 9.8 3.5 1.3 8.9 2.4 1.5 1 0 0 1 1 1 0 Ring finger domain Formyl_trans_N PF00551.14 CDF89897.1 - 3.1e-47 160.4 0.0 3.6e-47 160.2 0.0 1.0 1 0 0 1 1 1 1 Formyl transferase S1 PF00575.18 CDF89897.1 - 0.086 12.9 0.0 0.26 11.3 0.0 1.8 1 0 0 1 1 1 0 S1 RNA binding domain Proteasome PF00227.21 CDF89898.1 - 1.6e-46 157.9 0.1 2.2e-46 157.5 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.3 CDF89898.1 - 3.1e-16 58.3 0.1 6.8e-16 57.2 0.0 1.6 1 0 0 1 1 1 1 Proteasome beta subunits C terminal TRAPPC9-Trs120 PF08626.6 CDF89899.1 - 7.6e-303 1007.2 19.6 6.9e-302 1004.0 13.6 1.9 1 1 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit TPR_12 PF13424.1 CDF89899.1 - 0.0083 16.0 0.1 0.018 14.9 0.1 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat MiaE PF06175.6 CDF89899.1 - 0.015 14.6 0.3 0.033 13.5 0.2 1.5 1 0 0 1 1 1 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) Ku_C PF03730.9 CDF89900.1 - 5 7.7 15.9 0.68 10.5 1.3 2.8 3 0 0 3 3 3 0 Ku70/Ku80 C-terminal arm LSM PF01423.17 CDF89901.1 - 2.5e-12 46.1 0.1 3e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 LSM domain Xpo1 PF08389.7 CDF89902.1 - 7.2e-25 87.6 1.2 7.2e-25 87.6 0.8 4.4 5 1 1 6 6 6 1 Exportin 1-like protein IBN_N PF03810.14 CDF89902.1 - 4.8e-07 29.5 0.7 4.6e-06 26.4 0.3 2.9 2 0 0 2 2 2 1 Importin-beta N-terminal domain Rapamycin_bind PF08771.6 CDF89902.1 - 0.025 14.6 0.5 0.41 10.7 0.1 3.0 2 0 0 2 2 2 0 Rapamycin binding domain Choline_transpo PF04515.7 CDF89903.1 - 3.2e-84 282.5 19.4 3.2e-84 282.5 13.4 2.1 2 0 0 2 2 2 1 Plasma-membrane choline transporter PsbT PF01405.12 CDF89903.1 - 3.4 7.3 11.9 0.23 11.0 0.2 2.9 2 0 0 2 2 2 0 Photosystem II reaction centre T protein ISN1 PF06437.6 CDF89904.1 - 4.5e-177 588.8 0.0 5.2e-177 588.6 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase ABC2_membrane PF01061.19 CDF89905.1 - 5.7e-81 270.6 50.1 2.4e-45 154.3 12.5 2.7 3 0 0 3 3 2 2 ABC-2 type transporter PDR_CDR PF06422.7 CDF89905.1 - 2.8e-45 152.2 2.5 5.1e-38 128.8 0.1 3.1 2 0 0 2 2 2 2 CDR ABC transporter ABC_tran PF00005.22 CDF89905.1 - 3.9e-40 137.3 0.1 5.4e-19 68.8 0.0 3.5 3 0 0 3 3 3 2 ABC transporter ABC_trans_N PF14510.1 CDF89905.1 - 7.9e-21 73.9 0.0 2.2e-20 72.5 0.0 1.8 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal AAA_25 PF13481.1 CDF89905.1 - 7.7e-10 38.4 0.1 1.1e-05 24.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain ABC2_membrane_3 PF12698.2 CDF89905.1 - 1.8e-07 30.5 28.6 3.1e-07 29.7 3.4 2.8 2 1 0 2 2 2 1 ABC-2 family transporter protein AAA_16 PF13191.1 CDF89905.1 - 7.5e-07 29.3 0.4 3.3e-05 23.9 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_19 PF13245.1 CDF89905.1 - 0.00024 20.8 0.1 0.85 9.4 0.0 2.7 2 0 0 2 2 2 2 Part of AAA domain DUF258 PF03193.11 CDF89905.1 - 0.00043 19.5 0.1 0.0031 16.7 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_18 PF13238.1 CDF89905.1 - 0.00045 20.5 0.4 0.06 13.6 0.0 3.2 3 0 0 3 3 2 1 AAA domain cobW PF02492.14 CDF89905.1 - 0.00047 19.6 3.1 0.029 13.8 0.2 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.1 CDF89905.1 - 0.00052 19.4 1.0 0.0049 16.3 0.2 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_33 PF13671.1 CDF89905.1 - 0.00054 19.8 0.0 0.21 11.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 CDF89905.1 - 0.00074 19.6 0.1 0.083 13.0 0.0 2.9 2 1 0 2 2 2 1 AAA domain NACHT PF05729.7 CDF89905.1 - 0.0011 18.6 0.3 0.84 9.2 0.0 3.0 3 0 0 3 3 2 1 NACHT domain AAA_23 PF13476.1 CDF89905.1 - 0.0028 18.0 0.3 0.085 13.1 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.1 CDF89905.1 - 0.004 17.1 0.8 0.097 12.6 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.1 CDF89905.1 - 0.0042 17.0 0.0 0.094 12.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.14 CDF89905.1 - 0.016 14.4 0.1 1.6 7.9 0.0 2.9 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain UPF0079 PF02367.12 CDF89905.1 - 0.026 14.1 1.5 0.7 9.5 0.1 2.8 3 0 0 3 3 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_15 PF13175.1 CDF89905.1 - 0.038 13.0 0.3 0.27 10.2 0.0 2.4 3 0 0 3 3 3 0 AAA ATPase domain AAA_17 PF13207.1 CDF89905.1 - 0.04 14.7 0.0 2.2 9.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.20 CDF89905.1 - 0.083 12.3 0.0 0.93 8.9 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain NTPase_1 PF03266.10 CDF89905.1 - 0.18 11.5 1.3 25 4.5 0.0 3.0 3 0 0 3 3 3 0 NTPase PduV-EutP PF10662.4 CDF89905.1 - 0.24 10.8 1.0 2 7.9 0.1 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.1 CDF89905.1 - 0.3 10.6 0.8 7 6.1 0.2 2.3 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 CDF89905.1 - 0.35 10.2 1.2 22 4.3 0.0 2.4 2 0 0 2 2 2 0 AAA-like domain ABC2_membrane PF01061.19 CDF89906.1 - 5.2e-80 267.5 58.6 3.7e-43 147.1 15.6 2.8 3 0 0 3 3 3 2 ABC-2 type transporter PDR_CDR PF06422.7 CDF89906.1 - 4.8e-43 145.0 2.4 5.7e-37 125.5 0.0 2.8 2 0 0 2 2 2 2 CDR ABC transporter ABC_tran PF00005.22 CDF89906.1 - 2.8e-38 131.3 0.0 7.3e-18 65.1 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_trans_N PF14510.1 CDF89906.1 - 2.1e-17 62.9 0.1 5.5e-17 61.6 0.0 1.8 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal AAA_25 PF13481.1 CDF89906.1 - 5.5e-08 32.4 0.1 0.00016 21.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain ABC2_membrane_3 PF12698.2 CDF89906.1 - 2.8e-07 29.8 34.9 6.7e-05 22.0 5.1 3.0 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_16 PF13191.1 CDF89906.1 - 7.8e-06 25.9 0.5 0.00052 20.0 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain cobW PF02492.14 CDF89906.1 - 1.5e-05 24.4 1.7 0.0096 15.3 0.1 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.1 CDF89906.1 - 4.8e-05 23.6 0.3 0.037 14.3 0.0 3.1 3 0 0 3 3 3 1 AAA domain SMC_N PF02463.14 CDF89906.1 - 0.00012 21.3 0.0 0.0096 15.1 0.0 2.8 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain DUF258 PF03193.11 CDF89906.1 - 0.00012 21.2 0.0 0.003 16.7 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_19 PF13245.1 CDF89906.1 - 0.00018 21.1 0.3 0.44 10.3 0.0 2.7 2 0 0 2 2 2 2 Part of AAA domain NACHT PF05729.7 CDF89906.1 - 0.00054 19.6 0.0 1.4 8.5 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_29 PF13555.1 CDF89906.1 - 0.00059 19.3 1.2 0.0049 16.3 0.1 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_33 PF13671.1 CDF89906.1 - 0.00081 19.2 0.0 0.047 13.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 CDF89906.1 - 0.0011 19.1 0.0 0.54 10.4 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.1 CDF89906.1 - 0.0019 18.5 0.2 0.14 12.4 0.1 3.2 3 0 0 3 3 3 1 AAA domain AAA_21 PF13304.1 CDF89906.1 - 0.002 18.1 0.0 0.07 13.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.1 CDF89906.1 - 0.0053 16.7 1.2 0.13 12.2 0.1 2.7 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 CDF89906.1 - 0.006 17.3 0.2 0.57 11.0 0.0 3.0 3 0 0 3 3 2 1 AAA domain UPF0079 PF02367.12 CDF89906.1 - 0.0066 16.0 0.4 0.71 9.5 0.1 2.4 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_15 PF13175.1 CDF89906.1 - 0.043 12.8 0.1 0.14 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_10 PF12846.2 CDF89906.1 - 0.069 12.5 0.2 17 4.6 0.1 3.5 4 0 0 4 4 3 0 AAA-like domain Arch_ATPase PF01637.13 CDF89906.1 - 0.07 12.8 0.2 7.8 6.1 0.0 3.0 3 0 0 3 3 3 0 Archaeal ATPase PduV-EutP PF10662.4 CDF89906.1 - 0.075 12.5 0.4 2 7.8 0.1 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.1 CDF89906.1 - 0.2 11.2 1.0 6.7 6.2 0.2 2.4 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.10 CDF89906.1 - 1.2 8.8 2.5 35 4.0 0.1 3.2 4 0 0 4 4 4 0 NTPase DUF1330 PF07045.6 CDF89906.1 - 4.3 7.2 6.1 14 5.6 0.3 3.2 4 0 0 4 4 3 0 Protein of unknown function (DUF1330) ABC2_membrane PF01061.19 CDF89907.1 - 1.5e-80 269.2 56.0 9.4e-44 149.0 14.7 2.5 3 0 0 3 3 2 2 ABC-2 type transporter PDR_CDR PF06422.7 CDF89907.1 - 4.1e-39 132.4 2.4 3.4e-35 119.8 0.0 2.8 2 0 0 2 2 2 2 CDR ABC transporter ABC_tran PF00005.22 CDF89907.1 - 1.6e-38 132.0 0.4 2.2e-18 66.8 0.0 3.8 4 0 0 4 4 4 2 ABC transporter ABC_trans_N PF14510.1 CDF89907.1 - 7.3e-21 74.0 0.0 2.1e-20 72.5 0.0 1.8 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal AAA_25 PF13481.1 CDF89907.1 - 1.2e-08 34.5 0.0 5.5e-05 22.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 CDF89907.1 - 8.2e-07 29.1 0.5 9.8e-05 22.4 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain ABC2_membrane_3 PF12698.2 CDF89907.1 - 8.9e-06 24.9 34.8 0.0046 16.0 12.3 2.7 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_18 PF13238.1 CDF89907.1 - 4.3e-05 23.8 0.1 0.072 13.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain DUF258 PF03193.11 CDF89907.1 - 7e-05 22.0 0.0 0.002 17.3 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 cobW PF02492.14 CDF89907.1 - 0.00013 21.4 2.6 0.039 13.3 0.2 2.4 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.1 CDF89907.1 - 0.00016 21.5 0.0 0.39 10.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.14 CDF89907.1 - 0.00023 20.4 0.0 0.029 13.5 0.0 2.9 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 CDF89907.1 - 0.00024 20.5 0.8 0.0044 16.5 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.1 CDF89907.1 - 0.00024 21.2 0.1 0.054 13.6 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CDF89907.1 - 0.00034 20.3 0.5 0.44 10.3 0.0 2.5 2 0 0 2 2 2 2 Part of AAA domain AAA_21 PF13304.1 CDF89907.1 - 0.00048 20.1 0.0 0.057 13.3 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.1 CDF89907.1 - 0.00053 19.9 0.2 0.11 12.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 CDF89907.1 - 0.00081 19.0 0.1 1.5 8.4 0.0 2.6 2 0 0 2 2 2 2 NACHT domain UPF0079 PF02367.12 CDF89907.1 - 0.0068 16.0 0.7 0.88 9.2 0.1 2.5 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 AAA_17 PF13207.1 CDF89907.1 - 0.026 15.3 0.0 1.2 10.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 CDF89907.1 - 0.11 12.0 0.8 2.1 7.8 0.1 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.24 CDF89907.1 - 0.17 12.1 0.1 38 4.4 0.0 2.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.1 CDF89907.1 - 0.23 11.0 0.9 5.9 6.4 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 CDF89907.1 - 0.36 10.2 1.5 18 4.6 0.1 2.6 3 0 0 3 3 3 0 AAA-like domain AAA_23 PF13476.1 CDF89907.1 - 0.54 10.5 7.6 0.14 12.4 0.1 3.2 3 1 1 4 4 3 0 AAA domain TB2_DP1_HVA22 PF03134.14 CDF89908.1 - 0.14 11.9 4.1 0.057 13.1 0.7 2.1 1 1 1 2 2 2 0 TB2/DP1, HVA22 family Ribosomal_L23 PF00276.15 CDF89909.1 - 1.2e-22 79.5 0.6 5.4e-22 77.5 0.0 2.2 3 0 0 3 3 3 1 Ribosomal protein L23 RNA_pol_Rpb2_6 PF00562.23 CDF89910.1 - 7.9e-127 423.1 0.1 1.5e-126 422.2 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 CDF89910.1 - 1.2e-71 239.8 0.0 1.8e-71 239.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 CDF89910.1 - 1.7e-52 177.5 0.0 3.4e-52 176.6 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.15 CDF89910.1 - 2.8e-30 104.3 0.1 7.1e-30 103.0 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.8 CDF89910.1 - 2.7e-28 97.5 0.8 2.7e-28 97.5 0.5 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.11 CDF89910.1 - 6.7e-22 77.0 0.1 1.8e-21 75.6 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.12 CDF89910.1 - 9.1e-18 63.9 2.8 2.2e-17 62.7 1.9 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Ribosomal_L13 PF00572.13 CDF89911.1 - 7e-42 142.5 0.2 8.6e-42 142.2 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L13 SHS2_Rpb7-N PF03876.12 CDF89912.1 - 2e-17 63.0 0.0 3.9e-17 62.1 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.18 CDF89912.1 - 1.2e-15 57.2 0.1 1.8e-15 56.7 0.1 1.2 1 0 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.7 CDF89912.1 - 1.9e-06 28.0 0.0 3.2e-06 27.3 0.0 1.4 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 DIT1_PvcA PF05141.7 CDF89913.1 - 3.2e-102 341.5 0.0 4.7e-102 341.0 0.0 1.2 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein p450 PF00067.17 CDF89914.1 - 4.2e-54 183.8 0.0 5.2e-54 183.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 IU_nuc_hydro PF01156.14 CDF89915.1 - 2.3e-73 247.1 0.0 2.6e-73 246.9 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Pribosyltran PF00156.22 CDF89916.1 - 4e-10 39.5 0.1 9.9e-10 38.2 0.1 1.6 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Fe-ADH PF00465.14 CDF89916.1 - 0.0061 15.2 0.0 0.0093 14.6 0.0 1.3 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase 3Beta_HSD PF01073.14 CDF89916.1 - 0.044 12.4 0.0 0.058 12.0 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Mito_fiss_Elm1 PF06258.6 CDF89916.1 - 0.094 11.6 0.0 0.19 10.6 0.0 1.4 2 0 0 2 2 2 0 Mitochondrial fission ELM1 Utp12 PF04003.7 CDF89917.1 - 1.7e-20 72.9 0.6 3.2e-20 72.0 0.4 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family PilJ PF13675.1 CDF89917.1 - 0.1 12.9 1.1 0.33 11.2 0.1 2.2 2 1 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term YfhD PF14151.1 CDF89917.1 - 0.25 11.4 4.6 0.61 10.2 3.2 1.7 1 0 0 1 1 1 0 YfhD-like protein CBFD_NFYB_HMF PF00808.18 CDF89918.1 - 8.2e-14 51.4 1.5 1.3e-13 50.7 1.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone IBN_N PF03810.14 CDF89919.1 - 8.1e-20 70.5 1.2 3.2e-19 68.6 0.8 2.1 1 0 0 1 1 1 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.2 CDF89919.1 - 0.023 15.0 0.4 0.36 11.2 0.0 3.3 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region Glyco_transf_22 PF03901.12 CDF89920.1 - 1.1e-61 209.1 29.6 1.5e-61 208.6 20.5 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family AAA PF00004.24 CDF89921.1 - 3.8e-46 156.5 0.0 9.2e-46 155.3 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 CDF89921.1 - 5.5e-08 32.9 0.0 1.1e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 CDF89921.1 - 8e-08 32.1 0.1 3.4e-07 30.0 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.1 CDF89921.1 - 5.1e-07 29.8 0.2 2.1e-06 27.8 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 CDF89921.1 - 1.2e-06 28.6 0.5 0.00022 21.3 0.4 2.8 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.8 CDF89921.1 - 9.6e-05 21.4 0.0 0.00016 20.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.1 CDF89921.1 - 0.00017 21.5 0.0 0.0004 20.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 CDF89921.1 - 0.00053 19.1 0.0 0.0013 17.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus NTPase_1 PF03266.10 CDF89921.1 - 0.00059 19.5 0.1 0.0016 18.1 0.0 1.8 2 0 0 2 2 1 1 NTPase AAA_17 PF13207.1 CDF89921.1 - 0.0006 20.6 0.0 0.002 18.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 CDF89921.1 - 0.00095 18.3 0.0 0.0017 17.4 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_19 PF13245.1 CDF89921.1 - 0.0014 18.3 0.1 0.0038 16.9 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_25 PF13481.1 CDF89921.1 - 0.0019 17.6 0.7 0.051 12.9 0.0 2.3 1 1 0 2 2 2 1 AAA domain AAA_30 PF13604.1 CDF89921.1 - 0.0024 17.4 0.0 0.0064 16.0 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_11 PF13086.1 CDF89921.1 - 0.0024 17.4 0.0 0.0085 15.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.17 CDF89921.1 - 0.0029 17.7 0.0 0.0056 16.8 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_3 PF07726.6 CDF89921.1 - 0.0029 17.1 0.0 0.0078 15.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 CDF89921.1 - 0.0039 17.0 0.0 0.0079 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 CDF89921.1 - 0.0039 16.8 0.2 0.054 13.1 0.0 2.3 1 1 0 2 2 2 1 NACHT domain TIP49 PF06068.8 CDF89921.1 - 0.0041 15.8 0.0 0.0093 14.7 0.0 1.4 1 1 0 1 1 1 1 TIP49 C-terminus AAA_28 PF13521.1 CDF89921.1 - 0.0046 16.9 0.0 0.015 15.2 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_24 PF13479.1 CDF89921.1 - 0.005 16.4 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.16 CDF89921.1 - 0.0055 15.8 0.1 0.015 14.4 0.0 1.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 CDF89921.1 - 0.0061 16.0 0.0 0.18 11.2 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain UPF0079 PF02367.12 CDF89921.1 - 0.0065 16.0 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 IstB_IS21 PF01695.12 CDF89921.1 - 0.0094 15.3 0.0 0.028 13.8 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein Arch_ATPase PF01637.13 CDF89921.1 - 0.011 15.4 0.1 0.14 11.8 0.0 2.4 1 1 0 2 2 2 0 Archaeal ATPase AAA_18 PF13238.1 CDF89921.1 - 0.019 15.3 0.0 0.045 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 CDF89921.1 - 0.046 14.0 0.2 1.6 9.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain Bac_DnaA PF00308.13 CDF89921.1 - 0.089 12.4 0.0 0.21 11.2 0.0 1.6 1 1 0 1 1 1 0 Bacterial dnaA protein NB-ARC PF00931.17 CDF89921.1 - 0.11 11.3 0.0 0.2 10.5 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain She9_MDM33 PF05546.6 CDF89922.1 - 9.4e-91 302.9 16.2 8.1e-90 299.9 9.6 2.2 2 0 0 2 2 2 1 She9 / Mdm33 family CENP-Q PF13094.1 CDF89922.1 - 0.0019 18.2 15.6 0.0019 18.2 10.8 3.0 2 1 2 4 4 4 1 CENP-Q, a CENPA-CAD centromere complex subunit PsbH PF00737.15 CDF89922.1 - 0.0022 17.5 0.2 0.0045 16.5 0.2 1.4 1 0 0 1 1 1 1 Photosystem II 10 kDa phosphoprotein V_ATPase_I PF01496.14 CDF89922.1 - 0.1 10.4 6.2 0.14 10.0 4.3 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family OSTbeta PF15048.1 CDF89922.1 - 1.1 9.2 8.4 0.1 12.6 0.4 3.0 2 1 1 4 4 4 0 Organic solute transporter subunit beta protein Seryl_tRNA_N PF02403.17 CDF89922.1 - 1.3 9.0 21.0 0.021 14.8 8.1 2.6 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF1664 PF07889.7 CDF89922.1 - 1.8 8.3 7.4 7.2 6.4 0.9 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) G-patch_2 PF12656.2 CDF89923.1 - 1.1e-20 73.2 2.4 3.8e-20 71.5 0.0 2.4 2 0 0 2 2 2 1 DExH-box splicing factor binding site MDM31_MDM32 PF08118.6 CDF89924.1 - 4.3e-73 246.4 18.6 7e-36 123.7 3.1 4.0 2 1 2 4 4 4 4 Yeast mitochondrial distribution and morphology (MDM) proteins Vac_ImportDeg PF09783.4 CDF89924.1 - 0.024 14.1 0.2 0.024 14.1 0.2 2.5 3 0 0 3 3 3 0 Vacuolar import and degradation protein CpXC PF14353.1 CDF89924.1 - 0.11 12.5 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 CpXC protein KH_1 PF00013.24 CDF89925.1 - 0.00091 18.8 0.5 0.0018 17.8 0.3 1.4 1 0 0 1 1 1 1 KH domain PAP1 PF08601.5 CDF89925.1 - 0.023 14.4 0.1 0.027 14.1 0.0 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 AAA PF00004.24 CDF89926.1 - 0.004 17.3 0.4 0.013 15.7 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.8 CDF89926.1 - 0.038 13.4 0.8 0.13 11.7 0.0 2.2 2 0 0 2 2 2 0 DNA polymerase III, delta subunit TFIID-18kDa PF02269.11 CDF89927.1 - 3.1e-36 123.0 0.9 5.5e-35 119.0 0.1 2.4 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit TPK_catalytic PF04263.11 CDF89928.1 - 2.3e-25 88.5 0.0 4.7e-20 71.4 0.0 2.2 1 1 1 2 2 2 2 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.9 CDF89928.1 - 7.7e-11 41.5 0.1 1.3e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain CoA_binding PF02629.14 CDF89929.1 - 6.2e-24 84.3 5.8 1.4e-23 83.2 1.8 2.2 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.14 CDF89929.1 - 1.4e-22 79.9 0.3 2.1e-22 79.3 0.2 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.1 CDF89929.1 - 2.2e-05 24.1 0.0 4e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.1 CDF89929.1 - 0.00013 22.1 0.1 0.0004 20.5 0.0 1.8 2 0 0 2 2 2 1 CoA binding domain Actin PF00022.14 CDF89930.1 - 4.5e-23 81.3 0.0 5.3e-17 61.3 0.0 3.6 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.8 CDF89930.1 - 0.0013 17.3 0.0 0.2 10.2 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein HSF_DNA-bind PF00447.12 CDF89931.1 - 1.1e-35 121.9 0.2 1.1e-35 121.9 0.1 2.6 3 0 0 3 3 3 1 HSF-type DNA-binding Suf PF05843.9 CDF89931.1 - 5.7 6.5 15.1 2.1 8.0 8.4 1.8 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) UBA PF00627.26 CDF89932.1 - 1.1e-08 34.6 0.0 3.6e-08 33.0 0.0 2.0 1 0 0 1 1 1 1 UBA/TS-N domain UBA_4 PF14555.1 CDF89932.1 - 5.9e-06 25.7 0.0 1.5e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 UBA-like domain CUE PF02845.11 CDF89932.1 - 2e-05 23.9 0.0 0.00039 19.8 0.0 2.8 2 0 0 2 2 2 1 CUE domain Metallophos PF00149.23 CDF89933.1 - 2.9e-05 23.5 0.0 0.00014 21.3 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Iso_dh PF00180.15 CDF89934.1 - 2.1e-97 326.2 0.0 2.6e-97 325.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase ThiF PF00899.16 CDF89935.1 - 1.2e-33 115.8 0.0 2.6e-33 114.7 0.0 1.6 1 0 0 1 1 1 1 ThiF family UBACT PF02134.16 CDF89935.1 - 2.8e-26 90.8 0.3 6.9e-26 89.6 0.2 1.7 1 0 0 1 1 1 1 Repeat in ubiquitin-activating (UBA) protein UBA_e1_thiolCys PF10585.4 CDF89935.1 - 6.3e-21 73.5 4.1 1.1e-20 72.7 2.9 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site UAE_UbL PF14732.1 CDF89935.1 - 5.7e-05 23.1 2.1 6.4e-05 22.9 0.2 1.9 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Polysacc_synt_2 PF02719.10 CDF89935.1 - 0.09 11.6 0.0 0.17 10.7 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein BAR PF03114.13 CDF89937.1 - 1.6e-60 204.4 5.6 2.1e-60 204.1 3.9 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.23 CDF89937.1 - 3.4e-14 51.9 0.0 5.8e-14 51.2 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 CDF89937.1 - 5.9e-13 48.1 0.1 1e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 CDF89937.1 - 6.5e-08 31.9 0.0 1.4e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain DUF605 PF04652.11 CDF89937.1 - 3.9e-06 26.5 19.2 5.7e-06 25.9 13.3 1.2 1 0 0 1 1 1 1 Vta1 like LRRC37AB_C PF14914.1 CDF89937.1 - 0.02 14.3 0.5 0.079 12.3 0.1 1.9 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain Vps5 PF09325.5 CDF89937.1 - 0.05 12.8 2.1 2.6 7.2 0.0 2.2 2 0 0 2 2 2 0 Vps5 C terminal like Sugar_tr PF00083.19 CDF89938.1 - 7.2e-90 301.7 28.7 3.3e-88 296.2 19.9 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CDF89938.1 - 5.1e-27 94.5 31.7 2.5e-21 75.8 8.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CDF89938.1 - 5.1e-07 28.4 2.2 5.1e-07 28.4 1.6 3.7 3 1 1 4 4 4 2 MFS/sugar transport protein TRI12 PF06609.8 CDF89938.1 - 0.00023 19.5 14.2 0.0011 17.2 1.8 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.8 CDF89938.1 - 0.15 10.1 15.2 0.7 7.9 2.2 2.2 2 0 0 2 2 2 0 Transmembrane secretion effector DUF2061 PF09834.4 CDF89938.1 - 0.54 10.4 7.1 3.8 7.7 1.4 3.8 3 0 0 3 3 3 0 Predicted membrane protein (DUF2061) YqhR PF11085.3 CDF89938.1 - 1.4 8.4 11.3 0.3 10.6 0.1 3.2 2 1 1 3 3 3 0 Conserved membrane protein YqhR Phage_holin_2 PF04550.7 CDF89938.1 - 9.2 6.4 8.8 3.8 7.6 2.3 2.9 3 0 0 3 3 3 0 Phage holin family 2 ERCC4 PF02732.10 CDF89939.1 - 1.1e-23 83.6 0.2 1.8e-23 82.9 0.1 1.4 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.1 CDF89939.1 - 0.08 13.1 0.0 0.57 10.4 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix domain GTP_EFTU PF00009.22 CDF89940.1 - 1.9e-63 213.3 0.3 2.7e-63 212.8 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 CDF89940.1 - 5.8e-38 129.1 0.0 1.8e-37 127.5 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.19 CDF89940.1 - 2.9e-22 78.3 0.0 8.3e-22 76.8 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 CDF89940.1 - 1.6e-14 53.7 1.7 6.2e-14 51.8 0.0 2.9 4 0 0 4 4 4 1 Elongation factor Tu domain 2 EFG_II PF14492.1 CDF89940.1 - 5.2e-14 51.8 0.0 1.8e-13 50.1 0.0 1.9 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.18 CDF89940.1 - 1.2e-05 25.2 0.2 2.6e-05 24.1 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CDF89940.1 - 0.075 13.5 0.1 0.23 11.9 0.1 1.9 1 0 0 1 1 1 0 Miro-like protein PX PF00787.19 CDF89941.1 - 3.2e-05 23.6 0.0 6.2e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 PX domain Ion_trans_2 PF07885.11 CDF89942.1 - 2.3e-27 94.5 32.8 3.8e-17 61.7 6.2 3.3 3 0 0 3 3 3 2 Ion channel Lig_chan PF00060.21 CDF89942.1 - 0.082 12.6 10.0 1 9.0 1.0 3.4 3 1 0 3 3 3 0 Ligand-gated ion channel Grp1_Fun34_YaaH PF01184.14 CDF89944.1 - 2e-62 210.2 13.6 2.5e-62 209.8 9.4 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Cnl2_NKP2 PF09447.5 CDF89945.1 - 0.032 13.9 0.2 0.11 12.1 0.1 2.0 2 0 0 2 2 2 0 Cnl2/NKP2 family protein Ribosomal_60s PF00428.14 CDF89946.1 - 3.6e-23 81.7 7.4 4.2e-23 81.5 5.1 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF1308 PF07000.6 CDF89946.1 - 0.065 11.8 0.0 0.077 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1308) Mito_carr PF00153.22 CDF89947.1 - 5.1e-61 202.4 3.4 6.4e-20 70.6 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.22 CDF89948.1 - 5e-45 151.1 3.9 2.6e-15 55.9 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein UcrQ PF02939.11 CDF89948.1 - 0.1 12.4 0.6 0.31 10.8 0.4 1.8 1 0 0 1 1 1 0 UcrQ family GRP PF07172.6 CDF89949.1 - 0.026 15.0 0.0 0.032 14.7 0.0 1.2 1 0 0 1 1 1 0 Glycine rich protein family Trp_oprn_chp PF09534.5 CDF89949.1 - 0.11 12.1 0.3 0.17 11.5 0.2 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) RRM_1 PF00076.17 CDF89950.1 - 1.8e-12 46.7 0.0 3.2e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF89950.1 - 1.2e-09 38.0 0.0 2.2e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF89950.1 - 3.1e-05 23.7 0.1 6.4e-05 22.7 0.0 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.1 CDF89950.1 - 0.01 16.2 0.5 0.01 16.2 0.4 2.9 2 1 1 3 3 3 0 C-terminal duplication domain of Friend of PRMT1 Ribosomal_L12 PF00542.14 CDF89950.1 - 7.5 6.6 6.9 3.9 7.5 0.2 3.0 2 2 1 3 3 3 0 Ribosomal protein L7/L12 C-terminal domain HAD_2 PF13419.1 CDF89951.1 - 4.6e-11 43.2 0.0 5.4e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CDF89951.1 - 2.9e-06 27.8 0.0 3.3e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.1 CDF89951.1 - 0.043 13.6 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Pribosyl_synth PF14572.1 CDF89952.1 - 1.2e-41 142.5 2.8 6e-37 127.1 1.4 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.1 CDF89952.1 - 6.9e-39 132.1 0.2 1.2e-37 128.2 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.22 CDF89952.1 - 1.2e-11 44.3 0.9 3.9e-11 42.7 0.5 1.9 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.1 CDF89952.1 - 0.0078 15.4 0.1 0.013 14.7 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DUF218 PF02698.12 CDF89952.1 - 0.0088 15.5 0.0 0.032 13.7 0.0 1.9 2 0 0 2 2 2 1 DUF218 domain BRAP2 PF07576.7 CDF89953.1 - 2.4e-30 104.3 1.9 5.6e-30 103.1 1.3 1.6 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.14 CDF89953.1 - 5.6e-20 71.2 11.1 5.6e-20 71.2 7.7 1.8 2 0 0 2 2 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.1 CDF89953.1 - 6.6e-11 41.8 10.8 6.6e-11 41.8 7.5 2.1 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.1 CDF89953.1 - 2.2e-06 27.2 10.7 2.2e-06 27.2 7.4 2.4 2 0 0 2 2 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CDF89953.1 - 1.5e-05 24.9 10.2 1.5e-05 24.9 7.1 2.4 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDF89953.1 - 3.2e-05 23.5 10.8 3.2e-05 23.5 7.5 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 CDF89953.1 - 7e-05 22.8 5.6 7e-05 22.8 3.9 2.2 2 0 0 2 2 1 1 RING-H2 zinc finger zf-RING_UBOX PF13445.1 CDF89953.1 - 0.00028 20.5 5.9 0.00037 20.1 2.7 2.3 1 1 1 2 2 2 1 RING-type zinc-finger DMPK_coil PF08826.5 CDF89953.1 - 0.00099 18.9 19.6 0.061 13.2 7.6 2.5 2 0 0 2 2 2 2 DMPK coiled coil domain like zf-Apc11 PF12861.2 CDF89953.1 - 0.003 17.3 6.1 0.003 17.3 4.2 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Gryzun-like PF12742.2 CDF89953.1 - 0.15 11.9 0.1 0.32 10.8 0.1 1.5 1 0 0 1 1 1 0 Gryzun, putative Golgi trafficking Prok-RING_4 PF14447.1 CDF89953.1 - 0.78 9.3 11.5 12 5.5 0.1 3.3 2 1 0 3 3 3 0 Prokaryotic RING finger family 4 Hrs_helical PF12210.3 CDF89953.1 - 3.2 8.0 14.0 0.072 13.3 1.5 2.5 1 1 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate zf-RING_4 PF14570.1 CDF89953.1 - 5.2 6.7 19.3 0.019 14.5 6.0 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Form_Nir_trans PF01226.12 CDF89955.1 - 3e-60 203.2 15.6 3.6e-60 202.9 10.8 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter HEAT PF02985.17 CDF89956.1 - 0.00011 21.9 0.4 5.9 7.2 0.0 4.7 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.1 CDF89956.1 - 0.00045 20.4 0.1 0.025 14.8 0.0 3.4 3 0 0 3 3 3 1 HEAT repeats Cnd1 PF12717.2 CDF89956.1 - 0.011 15.5 10.6 0.031 14.1 0.4 4.2 5 0 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 PHD PF00628.24 CDF89957.1 - 3e-14 52.4 20.0 3.7e-11 42.5 5.2 3.0 2 1 1 3 3 3 2 PHD-finger zf-HC5HC2H PF13771.1 CDF89957.1 - 0.031 14.4 8.6 0.23 11.6 1.5 2.7 2 0 0 2 2 2 0 PHD-like zinc-binding domain C1_1 PF00130.17 CDF89957.1 - 0.068 12.9 11.4 0.29 10.8 0.8 2.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.1 CDF89957.1 - 0.095 12.4 0.2 0.095 12.4 0.1 3.0 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Rubredoxin PF00301.15 CDF89957.1 - 0.19 11.6 9.1 3.6 7.5 1.3 3.0 2 0 0 2 2 2 0 Rubredoxin zf-PHD-like PF15446.1 CDF89957.1 - 0.83 8.9 11.2 0.31 10.3 0.4 3.1 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain dsDNA_bind PF01984.15 CDF89958.1 - 5.1e-24 84.3 0.0 6.2e-24 84.0 0.0 1.1 1 0 0 1 1 1 1 Double-stranded DNA-binding domain Cu_amine_oxid PF01179.15 CDF89959.1 - 2.4e-152 507.4 0.0 2.9e-152 507.1 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.11 CDF89959.1 - 3.4e-06 27.0 0.0 1.7e-05 24.8 0.0 2.2 2 0 0 2 2 2 1 Copper amine oxidase, N2 domain Cyt-b5 PF00173.23 CDF89960.1 - 5.9e-19 67.6 0.1 8.5e-19 67.1 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain zinc_ribbon_6 PF14599.1 CDF89962.1 - 9.2e-26 89.4 3.5 9.2e-26 89.4 2.4 5.0 4 1 2 6 6 6 1 Zinc-ribbon zf-CHY PF05495.7 CDF89962.1 - 1.2e-09 38.1 27.5 1.2e-09 38.1 19.1 4.7 3 1 0 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.1 CDF89962.1 - 6.2e-08 32.3 10.6 6.2e-08 32.3 7.3 5.7 4 2 0 4 4 4 1 Ring finger domain zf-C3HC4_2 PF13923.1 CDF89962.1 - 7.9e-05 22.5 8.4 7.9e-05 22.5 5.8 5.5 3 3 4 7 7 7 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDF89962.1 - 0.0027 17.3 12.5 0.0027 17.3 8.6 6.8 3 2 3 6 6 6 2 zinc-RING finger domain Cg6151-P PF10233.4 CDF89963.1 - 1.3e-38 131.4 8.1 1.7e-38 131.0 5.6 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P ARL6IP6 PF15062.1 CDF89963.1 - 0.13 12.2 0.3 0.27 11.1 0.0 1.6 2 0 0 2 2 2 0 Haemopoietic lineage transmembrane helix DUF308 PF03729.8 CDF89963.1 - 7.5 6.6 16.7 1.3 9.1 0.7 3.2 2 1 2 4 4 4 0 Short repeat of unknown function (DUF308) CN_hydrolase PF00795.17 CDF89964.1 - 4.7e-32 110.8 0.0 6.1e-32 110.4 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase zf-C2H2_4 PF13894.1 CDF89965.1 - 6.3e-07 29.2 12.3 3.4e-05 23.8 2.2 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 CDF89965.1 - 9.1e-07 28.8 12.8 4.3e-05 23.6 1.8 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-Di19 PF05605.7 CDF89965.1 - 0.0003 20.8 4.1 0.0012 18.9 2.9 1.9 1 1 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.1 CDF89965.1 - 0.0013 18.9 14.1 0.37 11.1 0.1 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_2 PF12756.2 CDF89965.1 - 0.0013 18.7 3.5 0.48 10.5 0.8 2.2 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) DUF2225 PF09986.4 CDF89965.1 - 0.12 11.8 1.5 8.9 5.7 0.1 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-XS PF03470.9 CDF89965.1 - 1.3 9.0 4.5 3.3 7.8 0.4 2.7 2 0 0 2 2 2 0 XS zinc finger domain zf-met PF12874.2 CDF89965.1 - 1.5 9.1 5.3 1.9 8.8 0.3 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Acetyltransf_1 PF00583.19 CDF89966.1 - 7.7e-12 45.0 0.0 1.4e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 CDF89966.1 - 5.6e-05 22.8 0.0 0.00012 21.7 0.0 1.5 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_10 PF13673.1 CDF89966.1 - 0.00036 20.6 0.0 0.00054 20.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 CDF89966.1 - 0.00073 19.5 0.0 0.0012 18.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 CDF89966.1 - 0.0039 17.3 0.0 0.0068 16.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 CDF89966.1 - 0.038 14.1 0.0 0.062 13.4 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Synaphin PF05835.7 CDF89966.1 - 0.078 13.1 5.6 0.13 12.4 3.9 1.2 1 0 0 1 1 1 0 Synaphin protein TRAP_alpha PF03896.11 CDF89966.1 - 0.11 11.4 2.6 0.21 10.5 1.5 1.6 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit DUF2201_N PF13203.1 CDF89966.1 - 0.23 10.5 3.1 0.32 10.1 2.1 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain CDC45 PF02724.9 CDF89966.1 - 0.26 9.2 4.1 0.32 8.9 2.9 1.1 1 0 0 1 1 1 0 CDC45-like protein NIF PF03031.13 CDF89967.1 - 7.5e-53 178.4 0.0 1e-52 177.9 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF1514 PF07438.6 CDF89968.1 - 0.058 13.3 1.8 14 5.7 0.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1514) DUF948 PF06103.6 CDF89968.1 - 1.1 9.1 20.6 0.26 11.1 0.7 5.1 3 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF730 PF05325.6 CDF89968.1 - 2.6 7.8 9.8 7.7 6.3 0.3 3.7 2 2 1 3 3 3 0 Protein of unknown function (DUF730) Reo_sigmaC PF04582.7 CDF89968.1 - 3.1 6.8 26.2 0.6 9.2 3.3 4.2 1 1 4 5 5 5 0 Reovirus sigma C capsid protein Malic_M PF03949.10 CDF89969.1 - 6e-76 255.3 0.0 9e-76 254.7 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.14 CDF89969.1 - 9.3e-63 211.0 0.0 1.4e-62 210.4 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain DAO PF01266.19 CDF89970.1 - 1.7e-18 66.6 0.1 4.5e-18 65.2 0.0 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.9 CDF89970.1 - 0.0029 16.2 0.0 0.0086 14.7 0.0 1.7 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_8 PF13450.1 CDF89970.1 - 0.0062 16.5 0.0 0.022 14.7 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 CDF89970.1 - 0.041 12.7 0.1 0.075 11.8 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.22 CDF89970.1 - 0.075 13.4 0.2 0.24 11.8 0.1 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 CDF89970.1 - 0.19 10.7 0.1 0.47 9.4 0.1 1.6 2 0 0 2 2 2 0 FAD binding domain TFIIE_alpha PF02002.12 CDF89971.1 - 5.8e-33 112.5 0.1 2.1e-32 110.7 0.0 2.0 2 0 0 2 2 2 1 TFIIE alpha subunit TF_Zn_Ribbon PF08271.7 CDF89971.1 - 2.9e-11 42.5 0.4 9.3e-11 40.8 0.3 2.0 1 0 0 1 1 1 1 TFIIB zinc-binding DUF1759 PF03564.10 CDF89971.1 - 0.079 12.7 0.7 0.26 11.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) ThiF PF00899.16 CDF89972.1 - 2.1e-37 127.9 0.0 3.3e-37 127.3 0.0 1.3 1 0 0 1 1 1 1 ThiF family Saccharop_dh PF03435.13 CDF89972.1 - 0.0001 21.4 0.1 0.00027 20.0 0.0 1.7 1 1 0 1 1 1 1 Saccharopine dehydrogenase Shikimate_DH PF01488.15 CDF89972.1 - 0.0021 18.1 0.0 0.0043 17.1 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.1 CDF89972.1 - 0.0059 16.8 0.0 0.016 15.4 0.0 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding XdhC_C PF13478.1 CDF89972.1 - 0.026 14.8 0.0 0.11 12.8 0.0 2.0 2 0 0 2 2 2 0 XdhC Rossmann domain ApbA PF02558.11 CDF89972.1 - 0.038 13.4 0.0 0.075 12.4 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.13 CDF89972.1 - 0.052 13.5 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain DAO PF01266.19 CDF89972.1 - 0.1 11.5 0.0 0.47 9.2 0.0 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase Mito_carr PF00153.22 CDF89973.1 - 1.4e-62 207.4 1.3 1.2e-21 76.2 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.22 CDF89974.1 - 7.2e-62 205.1 3.0 1.9e-23 81.9 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.14 CDF89974.1 - 0.043 13.8 1.8 5.8 6.9 0.0 3.1 2 1 1 3 3 3 0 Tim17/Tim22/Tim23/Pmp24 family DUF2370 PF10176.4 CDF89975.1 - 9.2e-75 250.9 0.0 1.2e-74 250.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) SNF5 PF04855.7 CDF89976.1 - 5.8e-68 228.9 3.8 5.8e-68 228.9 2.6 3.4 2 2 0 2 2 2 1 SNF5 / SMARCB1 / INI1 MCPVI PF02993.9 CDF89976.1 - 3.3 7.7 47.3 0.18 11.9 12.2 2.6 2 0 0 2 2 2 0 Minor capsid protein VI DUF4557 PF15101.1 CDF89976.1 - 3.5 7.4 42.4 4.8 6.9 17.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) Adap_comp_sub PF00928.16 CDF89977.1 - 3.6e-29 101.6 0.0 4.9e-29 101.2 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family adh_short PF00106.20 CDF89978.1 - 6.2e-62 208.4 7.1 1.9e-30 105.9 1.9 2.6 2 0 0 2 2 2 2 short chain dehydrogenase MaoC_dehydratas PF01575.14 CDF89978.1 - 1.3e-31 108.5 0.0 2.3e-31 107.7 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain KR PF08659.5 CDF89978.1 - 4e-31 108.0 2.4 6.7e-16 58.4 0.4 2.4 2 0 0 2 2 2 2 KR domain MaoC_dehydrat_N PF13452.1 CDF89978.1 - 1.8e-05 24.5 0.0 0.0013 18.4 0.0 2.7 2 1 0 2 2 2 1 N-terminal half of MaoC dehydratase 3HCDH_N PF02737.13 CDF89978.1 - 0.31 10.6 4.5 0.91 9.1 0.0 2.4 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain QCR10 PF09796.4 CDF89979.1 - 8.8e-26 89.3 0.1 1.1e-25 89.0 0.1 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) UCR_6-4kD PF08997.5 CDF89979.1 - 5.5 6.7 5.9 10 5.9 4.1 1.5 1 1 0 1 1 1 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein Glyco_transf_15 PF01793.11 CDF89980.1 - 1.4e-127 425.2 10.8 1.8e-127 424.8 7.5 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Bromodomain PF00439.20 CDF89981.1 - 1.2e-32 111.6 3.9 1.9e-18 66.1 0.1 2.8 2 0 0 2 2 2 2 Bromodomain LAMTOR PF15454.1 CDF89982.1 - 2.9e-11 43.4 2.0 1.8e-10 40.9 1.3 1.9 2 0 0 2 2 2 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Luteo_P1-P2 PF08467.5 CDF89982.1 - 0.028 13.2 0.1 0.036 12.8 0.0 1.1 1 0 0 1 1 1 0 Luteovirus RNA polymerase P1-P2/replicase Ribosomal_L50 PF10501.4 CDF89983.1 - 3.6e-24 84.8 0.3 8.6e-24 83.6 0.2 1.7 1 0 0 1 1 1 1 Ribosomal subunit 39S Oxysterol_BP PF01237.13 CDF89986.1 - 1.5e-88 296.7 0.0 1.8e-88 296.4 0.0 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein PAP_central PF04928.12 CDF89987.1 - 2.5e-107 357.4 0.0 5.2e-107 356.3 0.0 1.5 2 0 0 2 2 2 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.10 CDF89987.1 - 1.5e-46 157.7 3.5 2.5e-46 157.0 2.4 1.3 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.18 CDF89987.1 - 3.3e-11 43.3 0.1 1.3e-10 41.4 0.0 2.0 1 0 0 1 1 1 1 Nucleotidyltransferase domain Dynamin_M PF01031.15 CDF89988.1 - 2.4e-104 348.2 0.1 5.5e-104 347.0 0.0 1.6 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.18 CDF89988.1 - 8.7e-55 185.0 0.0 2.4e-54 183.6 0.0 1.8 1 0 0 1 1 1 1 Dynamin family GED PF02212.13 CDF89988.1 - 2.4e-27 94.6 3.9 6e-27 93.3 2.7 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.18 CDF89988.1 - 0.00083 19.2 0.1 0.031 14.2 0.1 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CDF89988.1 - 0.029 14.8 0.0 0.079 13.4 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein APS_kinase PF01583.15 CDF89989.1 - 1.3e-74 249.0 0.0 1.6e-74 248.8 0.0 1.0 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.1 CDF89989.1 - 1.5e-08 34.6 0.0 2.5e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CDF89989.1 - 2.5e-05 25.0 0.1 3.5e-05 24.5 0.1 1.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CDF89989.1 - 6e-05 23.3 0.2 0.0003 21.0 0.1 2.0 1 1 1 2 2 2 1 AAA domain KTI12 PF08433.5 CDF89989.1 - 0.00011 21.5 0.0 0.00012 21.3 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_29 PF13555.1 CDF89989.1 - 0.00036 19.9 0.0 0.0006 19.2 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain CPT PF07931.7 CDF89989.1 - 0.013 15.1 0.3 0.19 11.3 0.2 2.4 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_21 PF13304.1 CDF89989.1 - 0.022 14.7 0.0 0.026 14.4 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 CDF89989.1 - 0.022 15.0 0.0 0.026 14.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 CDF89989.1 - 0.026 14.5 0.1 0.032 14.2 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain PRK PF00485.13 CDF89989.1 - 0.042 13.4 0.0 0.059 12.9 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family ABC_tran PF00005.22 CDF89989.1 - 0.12 12.6 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 ABC transporter Snf7 PF03357.16 CDF89990.1 - 6.4e-31 107.0 23.8 7.9e-30 103.4 15.1 2.0 2 0 0 2 2 2 2 Snf7 Ist1 PF03398.9 CDF89990.1 - 1.7e-06 27.5 6.3 2.6e-06 26.9 4.4 1.3 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway DUF87 PF01935.12 CDF89990.1 - 0.37 10.5 10.5 0.11 12.3 0.3 2.0 1 1 0 2 2 2 0 Domain of unknown function DUF87 Uds1 PF15456.1 CDF89990.1 - 0.56 10.2 11.0 0.16 11.9 0.6 2.6 2 1 0 2 2 2 0 Up-regulated During Septation Ribosomal_S6 PF01250.12 CDF89991.1 - 1.5e-07 31.1 0.0 2.2e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S6 PAP2 PF01569.16 CDF89992.1 - 3.9e-11 42.7 6.0 3.9e-11 42.7 4.1 2.4 2 1 1 3 3 3 1 PAP2 superfamily PAP2_3 PF14378.1 CDF89992.1 - 0.00049 19.6 10.6 0.00063 19.3 4.0 2.5 2 1 0 2 2 2 1 PAP2 superfamily Luteo_P1-P2 PF08467.5 CDF89992.1 - 0.037 12.8 1.3 0.052 12.3 0.9 1.1 1 0 0 1 1 1 0 Luteovirus RNA polymerase P1-P2/replicase TFIIS_M PF07500.9 CDF89993.1 - 8e-24 83.9 0.8 1.5e-23 83.0 0.6 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain PHD PF00628.24 CDF89993.1 - 3.2e-10 39.5 6.4 5.9e-10 38.6 4.5 1.5 1 0 0 1 1 1 1 PHD-finger zf-CW PF07496.10 CDF89993.1 - 0.097 12.3 1.0 0.26 11.0 0.7 1.7 1 0 0 1 1 1 0 CW-type Zinc Finger zinc_ribbon_5 PF13719.1 CDF89993.1 - 0.21 11.2 3.7 1.1 8.8 0.0 2.8 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 CDF89993.1 - 0.37 10.5 4.2 1.6 8.4 0.0 2.9 3 0 0 3 3 3 0 zinc-ribbon domain PHD_2 PF13831.1 CDF89993.1 - 1.7 8.0 6.7 6 6.2 4.6 1.9 1 1 0 1 1 1 0 PHD-finger Lar_restr_allev PF14354.1 CDF89993.1 - 2.1 8.7 6.0 10 6.4 4.1 2.1 1 1 0 1 1 1 0 Restriction alleviation protein Lar Ribosomal_L14e PF01929.12 CDF89994.1 - 3.6e-29 100.9 3.1 5.2e-29 100.4 2.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.24 CDF89994.1 - 0.0011 18.6 2.5 0.0021 17.7 1.7 1.5 1 0 0 1 1 1 1 KOW motif F-actin_cap_A PF01267.12 CDF89996.1 - 2.1e-78 263.1 2.4 2.4e-78 262.9 1.7 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit TRAM_LAG1_CLN8 PF03798.11 CDF89998.1 - 8.4e-32 110.3 24.8 8.4e-32 110.3 17.2 2.3 2 1 0 2 2 2 1 TLC domain TRAM1 PF08390.6 CDF89998.1 - 3.8e-25 87.1 0.6 1.1e-24 85.7 0.4 1.8 1 0 0 1 1 1 1 TRAM1-like protein Ribosomal_S2 PF00318.15 CDF89999.1 - 3.3e-59 199.6 0.0 8.1e-59 198.3 0.0 1.7 1 0 0 1 1 1 1 Ribosomal protein S2 MazG PF03819.12 CDF89999.1 - 0.014 15.3 0.1 0.027 14.4 0.0 1.5 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain Sec23_helical PF04815.10 CDF89999.1 - 0.069 12.5 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 Sec23/Sec24 helical domain Ribosomal_L10 PF00466.15 CDF90001.1 - 4e-17 61.9 0.0 5.6e-17 61.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 DUF4108 PF13390.1 CDF90001.1 - 0.1 12.3 0.0 0.28 10.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4108) HECT PF00632.20 CDF90002.1 - 6.4e-71 239.1 0.1 1.1e-70 238.3 0.1 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Pkinase PF00069.20 CDF90003.1 - 1.8e-72 243.6 0.0 2.7e-72 243.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF90003.1 - 1.1e-48 165.6 0.0 1.7e-48 164.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.23 CDF90003.1 - 1.9e-20 73.0 0.0 7.4e-20 71.1 0.0 2.2 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.1 CDF90003.1 - 5e-05 22.3 0.0 8.1e-05 21.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like CENP-C_C PF11699.3 CDF90004.1 - 5.3e-28 96.8 2.3 1.1e-27 95.7 1.6 1.6 1 0 0 1 1 1 1 Mif2/CENP-C like Mif2_N PF15624.1 CDF90004.1 - 5.7e-22 78.7 3.2 5.7e-22 78.7 2.2 3.8 4 0 0 4 4 4 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Cupin_2 PF07883.6 CDF90004.1 - 0.00011 21.5 0.0 0.00029 20.2 0.0 1.6 1 0 0 1 1 1 1 Cupin domain AT_hook PF02178.14 CDF90004.1 - 0.16 11.7 5.3 0.43 10.4 3.7 1.8 1 0 0 1 1 1 0 AT hook motif Smr PF01713.16 CDF90005.1 - 4.2e-16 58.9 0.0 9.9e-16 57.7 0.0 1.7 1 0 0 1 1 1 1 Smr domain CUE PF02845.11 CDF90005.1 - 9.9e-14 50.5 0.2 5.2e-06 25.8 0.0 3.0 3 0 0 3 3 3 2 CUE domain bZIP_1 PF00170.16 CDF90006.1 - 1.2e-07 31.6 19.0 1.2e-07 31.6 13.2 1.8 2 0 0 2 2 2 1 bZIP transcription factor Glutaredoxin2_C PF04399.8 CDF90006.1 - 0.00043 19.8 4.6 0.00088 18.8 3.2 1.5 1 0 0 1 1 1 1 Glutaredoxin 2, C terminal domain DUF2968 PF11180.3 CDF90006.1 - 0.085 12.2 13.6 0.16 11.3 9.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) CASP_C PF08172.7 CDF90006.1 - 0.1 11.6 14.2 0.042 12.8 7.8 1.9 1 1 1 2 2 2 0 CASP C terminal bZIP_Maf PF03131.12 CDF90006.1 - 0.21 11.9 16.7 0.038 14.2 9.0 1.7 2 0 0 2 2 2 0 bZIP Maf transcription factor APG6 PF04111.7 CDF90006.1 - 0.33 9.9 17.3 0.46 9.4 12.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 HisKA_2 PF07568.7 CDF90006.1 - 0.58 10.0 0.1 0.58 10.0 0.1 2.5 2 1 0 2 2 2 0 Histidine kinase bZIP_2 PF07716.10 CDF90006.1 - 1.3 8.9 20.6 0.74 9.6 12.6 1.9 1 1 1 2 2 2 0 Basic region leucine zipper DUF342 PF03961.8 CDF90006.1 - 1.6 7.0 6.5 2.1 6.6 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Flagellar_rod PF05149.7 CDF90006.1 - 2.6 7.1 22.2 16 4.5 15.4 1.9 1 1 0 1 1 1 0 Paraflagellar rod protein DUF349 PF03993.7 CDF90006.1 - 3.5 7.8 14.4 2.3 8.4 7.8 2.3 2 1 0 2 2 2 0 Domain of Unknown Function (DUF349) XhlA PF10779.4 CDF90006.1 - 4.3 7.3 7.5 6.2 6.8 4.6 1.8 1 1 0 1 1 1 0 Haemolysin XhlA DUF3416 PF11896.3 CDF90006.1 - 7.2 6.5 8.3 15 5.5 5.5 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3416) DUF572 PF04502.8 CDF90007.1 - 4.4e-53 180.6 7.5 5e-53 180.4 5.2 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) Mu-like_Com PF10122.4 CDF90007.1 - 0.00057 18.8 0.9 0.13 11.3 0.0 2.5 2 0 0 2 2 2 2 Mu-like prophage protein Com zf-FPG_IleRS PF06827.9 CDF90007.1 - 0.0067 16.0 1.7 1.1 8.9 0.1 2.5 2 0 0 2 2 2 2 Zinc finger found in FPG and IleRS Zn_Tnp_IS1 PF03811.8 CDF90007.1 - 0.018 14.4 0.7 1.1 8.8 0.1 2.4 2 0 0 2 2 2 0 InsA N-terminal domain zinc_ribbon_5 PF13719.1 CDF90007.1 - 0.035 13.7 2.1 5.9 6.5 0.1 2.9 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 CDF90007.1 - 0.05 13.2 2.2 7.4 6.3 0.1 2.9 3 0 0 3 3 3 0 zinc-ribbon domain APG6 PF04111.7 CDF90007.1 - 0.14 11.1 6.1 0.22 10.5 4.2 1.3 1 0 0 1 1 1 0 Autophagy protein Apg6 PA26 PF04636.8 CDF90007.1 - 1 7.9 3.8 1.4 7.5 2.7 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) UCR_14kD PF02271.11 CDF90007.1 - 1.5 8.6 7.2 0.66 9.7 1.9 2.4 3 0 0 3 3 3 0 Ubiquinol-cytochrome C reductase complex 14kD subunit V_ATPase_I PF01496.14 CDF90007.1 - 2.4 5.9 5.1 3.3 5.4 3.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Sugarporin_N PF11471.3 CDF90007.1 - 5.5 6.7 15.3 2.5 7.8 6.0 2.5 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension PAT1 PF09770.4 CDF90008.1 - 0.69 8.0 56.2 0.048 11.9 33.9 2.0 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 DUF1675 PF07897.6 CDF90008.1 - 0.77 9.5 23.1 0.026 14.3 11.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1675) Phosphodiest PF01663.17 CDF90009.1 - 1.6e-13 50.7 0.2 2.9e-13 49.8 0.1 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 CDF90009.1 - 0.0063 15.7 0.2 0.012 14.8 0.2 1.4 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.13 CDF90009.1 - 0.0067 15.8 2.1 0.013 14.8 1.4 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily MFS_1 PF07690.11 CDF90010.1 - 3.2e-36 124.7 34.2 3.2e-36 124.7 23.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CDF90010.1 - 1.2e-05 24.0 39.4 3.3e-05 22.6 25.5 2.9 1 1 0 1 1 1 1 Sugar (and other) transporter Fe-S_biosyn PF01521.15 CDF90011.1 - 4.4e-18 65.2 0.0 7.6e-18 64.4 0.0 1.3 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DUF3445 PF11927.3 CDF90012.1 - 3.2e-61 206.8 0.0 6.5e-61 205.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) DUF2758 PF10957.3 CDF90012.1 - 0.0027 17.4 0.0 0.008 15.9 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2758) AAA_2 PF07724.9 CDF90013.1 - 2.1e-46 157.9 0.0 1.1e-44 152.3 0.0 2.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA PF00004.24 CDF90013.1 - 1.2e-24 87.0 2.6 8.9e-14 51.8 0.0 2.9 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.4 CDF90013.1 - 1.1e-23 82.9 0.6 4.4e-23 80.9 0.4 2.2 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein Clp_N PF02861.15 CDF90013.1 - 8.6e-18 64.0 3.0 9.3e-12 44.6 0.4 3.2 2 0 0 2 2 2 2 Clp amino terminal domain AAA_5 PF07728.9 CDF90013.1 - 8.2e-17 61.2 0.0 1.5e-08 34.4 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.21 CDF90013.1 - 2.5e-12 46.6 0.2 2.9e-09 36.6 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.1 CDF90013.1 - 4.6e-09 36.5 0.2 0.0032 17.6 0.0 3.7 3 1 0 3 3 3 2 AAA domain AAA_16 PF13191.1 CDF90013.1 - 6.2e-09 36.0 12.2 0.00026 21.0 0.0 5.5 4 2 1 6 6 5 2 AAA ATPase domain TIP49 PF06068.8 CDF90013.1 - 1.5e-05 23.9 6.1 0.025 13.3 0.0 4.2 3 1 1 4 4 4 2 TIP49 C-terminus NACHT PF05729.7 CDF90013.1 - 0.00012 21.8 0.1 0.58 9.7 0.0 2.8 3 0 0 3 3 2 2 NACHT domain Mg_chelatase PF01078.16 CDF90013.1 - 0.00017 20.8 0.0 0.39 9.8 0.0 3.6 4 0 0 4 4 4 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 CDF90013.1 - 0.00082 19.0 0.0 0.69 9.7 0.0 2.7 2 0 0 2 2 2 1 Part of AAA domain Zeta_toxin PF06414.7 CDF90013.1 - 0.0011 18.0 0.3 0.055 12.5 0.0 3.2 3 0 0 3 3 3 1 Zeta toxin AAA_3 PF07726.6 CDF90013.1 - 0.0022 17.6 0.0 0.32 10.5 0.0 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 CDF90013.1 - 0.0023 17.7 3.2 0.16 11.8 0.0 4.0 4 1 0 4 4 4 1 AAA domain AAA_17 PF13207.1 CDF90013.1 - 0.0027 18.5 8.0 0.27 12.0 0.0 4.3 4 1 0 4 4 3 2 AAA domain Torsin PF06309.6 CDF90013.1 - 0.0034 17.2 0.0 0.013 15.4 0.0 1.9 2 0 0 2 2 1 1 Torsin Arch_ATPase PF01637.13 CDF90013.1 - 0.0036 17.0 2.9 1 9.0 0.0 4.2 3 1 1 4 4 4 1 Archaeal ATPase AAA_18 PF13238.1 CDF90013.1 - 0.0049 17.1 0.5 6.6 7.0 0.0 4.1 3 0 0 3 3 3 0 AAA domain IstB_IS21 PF01695.12 CDF90013.1 - 0.018 14.4 0.0 0.86 8.9 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein MobB PF03205.9 CDF90013.1 - 0.056 13.1 0.0 8.3 6.1 0.0 3.0 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B PEPCK_ATP PF01293.15 CDF90013.1 - 0.064 11.7 0.0 0.14 10.6 0.0 1.5 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase ABC_tran PF00005.22 CDF90013.1 - 0.22 11.8 3.5 6.5 7.0 0.0 3.6 3 0 0 3 3 3 0 ABC transporter Uds1 PF15456.1 CDF90013.1 - 1.1 9.2 19.2 0.13 12.2 9.3 2.4 3 0 0 3 3 2 0 Up-regulated During Septation RRM_1 PF00076.17 CDF90014.1 - 1.6e-27 94.9 5.0 4.2e-14 51.9 0.1 4.1 4 1 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF90014.1 - 8.1e-21 73.6 0.2 5e-08 32.6 0.1 3.7 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF90014.1 - 5.3e-19 67.9 0.3 1.7e-08 34.3 0.1 3.4 3 0 0 3 3 3 2 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CDF90014.1 - 0.00022 20.9 0.1 0.87 9.4 0.0 3.2 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.6 CDF90014.1 - 0.0025 17.6 0.2 0.4 10.5 0.1 2.7 2 0 0 2 2 2 1 RNA binding motif KIAA1430 PF13879.1 CDF90014.1 - 0.02 15.3 1.5 0.049 14.0 0.4 2.2 2 0 0 2 2 2 0 KIAA1430 homologue NPR3 PF03666.8 CDF90015.1 - 2.3e-156 520.8 0.0 2.3e-156 520.8 0.0 2.0 2 1 0 2 2 2 1 Nitrogen Permease regulator of amino acid transport activity 3 HSP70 PF00012.15 CDF90016.1 - 5.6e-273 906.3 7.4 6.4e-273 906.1 5.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 CDF90016.1 - 5e-17 61.5 0.0 6.5e-16 57.8 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein DDR PF08841.5 CDF90016.1 - 0.003 16.4 0.2 0.019 13.8 0.0 2.1 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain FGGY_C PF02782.11 CDF90016.1 - 0.0091 15.6 0.0 0.021 14.4 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.13 CDF90016.1 - 0.037 13.1 1.3 0.13 11.3 0.0 2.4 2 1 1 3 3 3 0 Hydantoinase/oxoprolinase StbA PF06406.6 CDF90016.1 - 0.038 12.9 0.0 0.07 12.0 0.0 1.4 1 0 0 1 1 1 0 StbA protein UPF0121 PF03661.8 CDF90017.1 - 1.2e-12 47.6 2.6 1.6e-12 47.1 1.8 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) Hum_adeno_E3A PF05393.6 CDF90017.1 - 0.27 10.9 0.1 0.27 10.9 0.0 2.8 2 1 0 2 2 2 0 Human adenovirus early E3A glycoprotein SHNi-TPR PF10516.4 CDF90018.1 - 8.5e-10 37.7 0.7 3.1e-09 35.9 0.5 2.1 1 0 0 1 1 1 1 SHNi-TPR TPR_11 PF13414.1 CDF90018.1 - 1.6e-08 34.0 0.8 0.0015 18.0 0.0 2.9 2 1 0 2 2 2 2 TPR repeat TPR_12 PF13424.1 CDF90018.1 - 8.6e-08 32.0 1.6 0.00017 21.4 0.3 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 CDF90018.1 - 8.1e-07 28.4 3.0 0.01 15.7 0.2 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.1 CDF90018.1 - 7.3e-06 25.4 0.9 0.12 12.2 0.7 4.1 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.1 CDF90018.1 - 1.5e-05 25.4 1.5 0.012 16.2 0.0 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.1 CDF90018.1 - 0.00092 19.6 1.6 3.7 8.4 0.0 3.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.23 CDF90018.1 - 0.0012 18.3 7.5 1.2 8.8 0.3 4.3 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.1 CDF90018.1 - 0.029 14.6 9.3 0.067 13.5 0.0 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.1 CDF90018.1 - 0.032 14.0 5.0 1.7 8.6 0.6 4.1 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.1 CDF90018.1 - 0.052 13.4 0.0 12 5.8 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 CDF90018.1 - 0.071 13.5 5.4 1.8 9.2 0.2 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF2225 PF09986.4 CDF90018.1 - 5.7 6.3 7.2 0.56 9.6 1.0 2.4 3 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) Septin PF00735.13 CDF90019.1 - 1.3e-113 378.6 0.3 1.3e-113 378.6 0.2 1.8 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.18 CDF90019.1 - 3.3e-05 23.8 0.0 0.00015 21.7 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 CDF90019.1 - 0.0025 17.0 0.8 0.0089 15.2 0.5 1.9 1 1 0 1 1 1 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 CDF90019.1 - 0.028 13.8 1.2 0.27 10.6 0.1 2.7 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.1 CDF90019.1 - 0.075 13.0 0.2 0.33 10.9 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain MAP7 PF05672.6 CDF90019.1 - 0.079 12.3 17.4 0.17 11.2 12.1 1.5 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family GAGA_bind PF06217.7 CDF90019.1 - 0.17 11.8 4.8 0.28 11.1 3.3 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Exonuc_VII_L PF02601.10 CDF90019.1 - 0.22 10.6 7.5 0.42 9.7 5.2 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF342 PF03961.8 CDF90019.1 - 0.32 9.3 8.8 0.53 8.6 6.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Dynamin_N PF00350.18 CDF90019.1 - 1.2 8.9 9.5 4.4 7.1 0.9 3.4 2 1 0 2 2 2 0 Dynamin family V_ATPase_I PF01496.14 CDF90019.1 - 5.8 4.6 11.7 8.8 4.0 8.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family E1-E2_ATPase PF00122.15 CDF90020.1 - 8.7e-46 155.8 0.0 2e-45 154.6 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 CDF90020.1 - 2.4e-37 129.4 0.0 6.4e-37 128.0 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.21 CDF90020.1 - 5.2e-24 84.1 2.2 2.6e-08 33.8 0.0 5.0 5 0 0 5 5 5 3 Heavy-metal-associated domain HAD PF12710.2 CDF90020.1 - 1.8e-19 70.6 0.0 3.6e-19 69.6 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CDF90020.1 - 0.00016 21.3 0.7 0.0088 15.6 0.0 2.9 2 1 1 3 3 3 1 haloacid dehalogenase-like hydrolase NnrU PF07298.6 CDF90020.1 - 0.43 9.9 9.1 0.25 10.6 0.5 3.4 3 1 0 3 3 3 0 NnrU protein Tox-PL-2 PF15643.1 CDF90020.1 - 2.9 7.9 7.9 17 5.4 0.1 3.7 3 1 1 4 4 4 0 Papain fold toxin 2 DUF3795 PF12675.2 CDF90020.1 - 3 8.0 9.2 1.8 8.7 1.4 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF3795) GIT_SHD PF08518.6 CDF90021.1 - 4.6e-27 93.0 5.3 8e-14 50.7 0.2 2.5 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT DivIC PF04977.10 CDF90021.1 - 0.023 14.1 6.2 1.3 8.5 1.1 3.6 1 1 1 2 2 2 0 Septum formation initiator FlaC_arch PF05377.6 CDF90021.1 - 0.59 10.0 8.8 0.061 13.2 0.4 3.3 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) GnHR_trans PF12369.3 CDF90021.1 - 0.94 9.9 11.8 1.4 9.4 0.7 4.3 3 0 0 3 3 3 0 Gonadotropin hormone receptor transmembrane region IncA PF04156.9 CDF90021.1 - 8.9 5.8 13.9 1.5 8.3 4.7 2.9 2 0 0 2 2 2 0 IncA protein Ribonucleas_3_3 PF14622.1 CDF90022.1 - 5e-22 78.2 0.1 9.1e-22 77.3 0.1 1.4 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.21 CDF90022.1 - 4.7e-05 23.8 0.2 0.00012 22.4 0.1 1.8 2 0 0 2 2 2 1 Ribonuclease III domain DUF3589 PF12141.3 CDF90024.1 - 4.9e-91 305.4 0.2 2.6e-90 303.0 0.1 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3589) Pkinase PF00069.20 CDF90025.1 - 3e-46 157.7 0.0 1.2e-45 155.7 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF90025.1 - 2e-17 63.1 0.0 4.8e-17 61.8 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF90025.1 - 0.17 10.7 0.0 0.45 9.4 0.0 1.6 2 0 0 2 2 2 0 Kinase-like CHCH PF06747.8 CDF90026.1 - 3.8e-05 23.4 0.8 6.9e-05 22.6 0.5 1.5 1 1 0 1 1 1 1 CHCH domain Pet191_N PF10203.4 CDF90026.1 - 0.039 13.9 2.9 0.098 12.7 2.0 1.6 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.5 CDF90026.1 - 0.041 13.6 2.2 0.057 13.2 1.5 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like UPF0203 PF05254.7 CDF90026.1 - 0.34 10.7 2.9 4.5 7.1 0.2 2.0 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) tRNA-synt_2 PF00152.15 CDF90027.1 - 5.9e-82 275.1 0.2 9.8e-82 274.4 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 CDF90027.1 - 2.2e-07 30.6 0.0 4.8e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain TFIIB PF00382.14 CDF90028.1 - 4.6e-42 141.6 3.8 2.9e-27 94.2 1.7 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 CDF90028.1 - 9.5e-14 50.4 0.5 1.7e-13 49.5 0.4 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding RasGEF PF00617.14 CDF90029.1 - 1.5e-59 200.9 3.7 1.4e-58 197.7 0.1 2.7 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.15 CDF90029.1 - 3.4e-16 59.2 0.0 3.4e-16 59.2 0.0 3.2 3 0 0 3 3 3 1 RasGEF N-terminal motif SH3_9 PF14604.1 CDF90029.1 - 1.1e-08 34.5 0.1 2.6e-08 33.3 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 CDF90029.1 - 1.6e-07 30.6 0.0 3e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 CDF90029.1 - 6e-07 28.8 0.0 1.2e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain OmpH PF03938.9 CDF90029.1 - 0.32 10.9 35.5 1.1 9.2 24.6 1.8 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) GRIP PF01465.15 CDF90030.1 - 1.9e-15 56.0 0.4 5.3e-15 54.6 0.3 1.8 1 0 0 1 1 1 1 GRIP domain WEMBL PF05701.6 CDF90030.1 - 0.00027 19.5 55.2 0.00027 19.5 38.3 3.2 2 1 1 3 3 3 1 Weak chloroplast movement under blue light GAS PF13851.1 CDF90030.1 - 0.0078 15.4 14.4 0.0078 15.4 10.0 7.5 2 2 4 7 7 7 4 Growth-arrest specific micro-tubule binding Reo_sigmaC PF04582.7 CDF90030.1 - 0.39 9.8 68.9 0.073 12.2 7.4 7.2 2 2 7 9 9 9 0 Reovirus sigma C capsid protein Myosin_tail_1 PF01576.14 CDF90030.1 - 0.91 7.1 134.5 0.075 10.7 25.6 3.1 1 1 1 3 3 3 0 Myosin tail Filament PF00038.16 CDF90030.1 - 2.3 7.6 107.2 0.24 10.8 11.8 6.0 2 1 3 5 5 5 0 Intermediate filament protein DUF3450 PF11932.3 CDF90030.1 - 3.4 6.8 93.8 0.2 10.9 6.6 8.7 4 2 3 9 9 9 0 Protein of unknown function (DUF3450) IncA PF04156.9 CDF90030.1 - 7.6 6.0 138.5 0.14 11.6 7.8 8.1 2 2 5 7 7 7 0 IncA protein DUF3584 PF12128.3 CDF90030.1 - 8.2 3.6 116.3 0.019 12.3 15.1 4.1 2 1 2 4 4 4 0 Protein of unknown function (DUF3584) Polysacc_deac_1 PF01522.16 CDF90031.1 - 5.9e-26 90.5 0.0 9.9e-26 89.8 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.10 CDF90031.1 - 3e-05 23.1 0.0 4.1e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 UQ_con PF00179.21 CDF90032.1 - 3.3e-31 107.5 0.0 4e-31 107.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CDF90032.1 - 0.036 13.8 0.1 0.049 13.3 0.1 1.6 1 1 0 1 1 1 0 Prokaryotic E2 family B PI3_PI4_kinase PF00454.22 CDF90033.1 - 2.5e-43 148.2 0.0 9.1e-43 146.4 0.0 2.0 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.15 CDF90033.1 - 2.8e-25 88.5 2.5 4.2e-25 87.9 0.4 2.4 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Zip PF02535.17 CDF90034.1 - 0.04 12.9 1.8 0.061 12.3 1.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DUF1510 PF07423.6 CDF90034.1 - 0.046 13.0 19.4 0.056 12.8 13.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) DUF874 PF05917.6 CDF90034.1 - 0.24 10.2 9.8 0.28 10.0 6.8 1.0 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) DUF2615 PF11027.3 CDF90034.1 - 0.38 10.7 1.9 0.55 10.1 0.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2615) GAGA_bind PF06217.7 CDF90034.1 - 0.4 10.6 9.5 0.47 10.3 6.6 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family CobT PF06213.7 CDF90034.1 - 0.85 8.6 20.1 0.97 8.5 13.9 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Tom5 PF10642.4 CDF90034.1 - 1.4 8.6 0.0 1.4 8.6 0.0 2.5 2 0 0 2 2 2 0 Mitochondrial import receptor subunit or translocase Serinc PF03348.10 CDF90034.1 - 1.8 7.1 5.3 2.9 6.5 3.7 1.4 1 1 0 1 1 1 0 Serine incorporator (Serinc) Ycf1 PF05758.7 CDF90034.1 - 1.8 6.1 8.7 1.6 6.3 6.0 1.0 1 0 0 1 1 1 0 Ycf1 Hid1 PF12722.2 CDF90034.1 - 4.3 4.9 9.5 3.8 5.0 6.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Conotoxin PF02950.12 CDF90034.1 - 4.8 8.0 6.6 2.8e+02 2.3 4.6 2.5 1 1 0 1 1 1 0 Conotoxin PBP_sp32 PF07222.7 CDF90034.1 - 5.6 6.0 13.1 6.6 5.8 9.1 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 CDC45 PF02724.9 CDF90034.1 - 6.1 4.7 16.2 7 4.5 11.2 1.3 1 0 0 1 1 1 0 CDC45-like protein Aconitase PF00330.15 CDF90035.1 - 4.4e-178 592.5 0.1 9.5e-178 591.4 0.0 1.5 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 CDF90035.1 - 3.2e-48 163.1 0.1 6.6e-48 162.1 0.1 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain ABC_membrane PF00664.18 CDF90036.1 - 3.7e-60 203.6 37.2 1.1e-32 113.5 5.8 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 CDF90036.1 - 7e-48 162.4 0.5 6.5e-29 100.9 0.0 2.8 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.14 CDF90036.1 - 7.4e-11 41.7 4.8 0.015 14.5 2.2 4.1 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CDF90036.1 - 2.4e-09 37.5 6.9 0.3 11.0 0.0 5.6 4 1 0 4 4 4 3 AAA domain AAA_29 PF13555.1 CDF90036.1 - 7.3e-07 28.6 0.4 0.016 14.6 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.1 CDF90036.1 - 1.3e-06 28.5 2.1 0.03 14.3 0.0 2.7 3 0 0 3 3 2 2 AAA ATPase domain MMR_HSR1 PF01926.18 CDF90036.1 - 1.5e-05 24.9 0.2 0.18 11.7 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_17 PF13207.1 CDF90036.1 - 2.3e-05 25.1 0.0 0.59 10.9 0.0 3.2 2 1 0 2 2 2 2 AAA domain AAA_22 PF13401.1 CDF90036.1 - 2.6e-05 24.3 0.8 0.071 13.2 0.0 3.2 2 1 0 2 2 2 2 AAA domain AAA_25 PF13481.1 CDF90036.1 - 3.4e-05 23.3 0.1 0.084 12.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_10 PF12846.2 CDF90036.1 - 0.00043 19.8 2.8 0.76 9.1 0.1 3.3 3 1 0 4 4 4 2 AAA-like domain T2SE PF00437.15 CDF90036.1 - 0.00045 19.1 0.0 0.38 9.6 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein ABC_ATPase PF09818.4 CDF90036.1 - 0.00047 18.8 1.3 0.13 10.8 0.0 2.4 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_33 PF13671.1 CDF90036.1 - 0.0011 18.8 0.6 0.41 10.4 0.0 3.2 3 0 0 3 3 3 1 AAA domain Dynamin_N PF00350.18 CDF90036.1 - 0.0014 18.4 3.8 0.15 11.8 0.0 3.8 3 1 0 3 3 3 1 Dynamin family NB-ARC PF00931.17 CDF90036.1 - 0.0026 16.6 3.6 5 5.8 0.0 4.5 4 1 1 5 5 5 0 NB-ARC domain DUF258 PF03193.11 CDF90036.1 - 0.0028 16.8 1.5 0.78 8.9 0.0 3.2 3 0 0 3 3 3 1 Protein of unknown function, DUF258 AAA_18 PF13238.1 CDF90036.1 - 0.0039 17.5 0.0 2.4 8.4 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.1 CDF90036.1 - 0.0042 16.6 1.8 2.4 7.6 0.0 3.2 2 1 0 2 2 2 1 AAA domain Miro PF08477.8 CDF90036.1 - 0.007 16.8 2.3 5.2 7.5 0.0 3.4 3 0 0 3 3 3 0 Miro-like protein MobB PF03205.9 CDF90036.1 - 0.0078 15.9 0.7 1.8 8.2 0.0 2.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B FtsK_SpoIIIE PF01580.13 CDF90036.1 - 0.011 15.2 0.1 1.9 7.9 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family GTP_EFTU PF00009.22 CDF90036.1 - 0.053 12.9 0.0 4.7 6.6 0.0 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain PC4 PF02229.11 CDF90036.1 - 0.065 12.4 0.3 21 4.4 0.0 3.4 3 0 0 3 3 3 0 Transcriptional Coactivator p15 (PC4) AIF_C PF14721.1 CDF90036.1 - 0.094 12.9 0.4 0.34 11.1 0.1 2.1 1 1 1 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Zeta_toxin PF06414.7 CDF90036.1 - 0.11 11.5 3.1 3.7 6.5 0.0 2.9 3 0 0 3 3 3 0 Zeta toxin Transketolase_N PF00456.16 CDF90036.1 - 0.16 10.7 0.2 0.25 10.0 0.1 1.2 1 0 0 1 1 1 0 Transketolase, thiamine diphosphate binding domain cobW PF02492.14 CDF90036.1 - 0.18 11.2 4.0 0.46 9.9 0.0 3.0 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.7 CDF90036.1 - 0.33 10.6 2.9 1.9 8.0 0.0 3.0 3 0 0 3 3 2 0 NACHT domain DUF87 PF01935.12 CDF90036.1 - 0.8 9.4 6.6 0.52 10.0 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function DUF87 AAA_23 PF13476.1 CDF90036.1 - 2.4 8.4 13.4 11 6.2 4.0 3.5 2 2 0 2 2 2 0 AAA domain AAA PF00004.24 CDF90036.1 - 2.5 8.2 5.4 23 5.1 0.4 4.0 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Cys_Met_Meta_PP PF01053.15 CDF90037.1 - 1.4e-146 487.7 0.0 1.6e-146 487.5 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.12 CDF90037.1 - 1.8e-13 50.2 0.1 1.6e-12 47.1 0.0 2.1 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.16 CDF90037.1 - 4.7e-11 42.2 0.0 7.4e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 CDF90037.1 - 8.9e-09 34.5 0.0 1.3e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 CDF90037.1 - 4.7e-06 25.9 0.0 1.1e-05 24.7 0.0 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase Met_gamma_lyase PF06838.6 CDF90037.1 - 0.0003 19.2 0.2 0.00047 18.5 0.1 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase GDC-P PF02347.11 CDF90037.1 - 0.031 12.9 0.0 0.044 12.4 0.0 1.2 1 0 0 1 1 1 0 Glycine cleavage system P-protein SLA_LP_auto_ag PF05889.8 CDF90037.1 - 0.2 10.0 0.0 0.28 9.5 0.0 1.2 1 0 0 1 1 1 0 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) Acid_PPase PF12689.2 CDF90038.1 - 5.5e-45 153.0 0.0 6.4e-45 152.8 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase DUF217 PF02697.9 CDF90038.1 - 0.067 13.4 0.2 0.16 12.2 0.2 1.6 1 0 0 1 1 1 0 Uncharacterized ACR, COG1753 AcetylCoA_hydro PF02550.10 CDF90039.1 - 1.1e-61 208.0 0.0 1.9e-61 207.2 0.0 1.4 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.1 CDF90039.1 - 1e-39 135.6 0.0 1.6e-39 135.0 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain Pkinase PF00069.20 CDF90040.1 - 1.5e-72 243.8 0.0 1.8e-72 243.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF90040.1 - 4e-32 111.2 0.0 5.1e-32 110.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF90040.1 - 0.0014 17.6 0.0 0.0031 16.5 0.0 1.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 CDF90040.1 - 0.033 13.9 0.1 0.085 12.5 0.1 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 CDF90040.1 - 0.11 11.5 0.2 0.21 10.6 0.1 1.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family BNR PF02012.15 CDF90041.1 - 2e-10 38.8 42.9 0.38 10.7 0.0 13.2 13 0 0 13 13 13 9 BNR/Asp-box repeat Exo_endo_phos PF03372.18 CDF90043.1 - 1.7e-14 54.3 0.0 2.5e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.1 CDF90043.1 - 8.7e-12 44.7 0.0 2.8e-10 39.8 0.0 2.3 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase zf-GRF PF06839.7 CDF90043.1 - 8.3e-10 38.4 0.2 2.1e-09 37.1 0.2 1.8 1 0 0 1 1 1 1 GRF zinc finger Rft-1 PF04506.8 CDF90044.1 - 7.8e-170 565.8 31.1 8.9e-170 565.6 21.6 1.0 1 0 0 1 1 1 1 Rft protein CBFD_NFYB_HMF PF00808.18 CDF90045.1 - 1e-25 89.5 0.1 1.6e-25 88.9 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 CDF90045.1 - 3.1e-06 27.2 0.0 5.4e-06 26.4 0.0 1.4 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.8 CDF90045.1 - 0.021 14.5 0.0 0.078 12.7 0.0 1.8 2 0 0 2 2 2 0 Bromodomain associated TFIID_20kDa PF03847.8 CDF90045.1 - 0.054 13.7 0.3 0.22 11.8 0.1 2.0 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A Lon_C PF05362.8 CDF90046.1 - 2.5e-65 219.6 0.0 5.1e-65 218.6 0.0 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON PF02190.11 CDF90046.1 - 6.2e-40 137.0 0.6 2e-39 135.4 0.4 1.9 1 0 0 1 1 1 1 ATP-dependent protease La (LON) domain AAA PF00004.24 CDF90046.1 - 1.9e-23 83.0 0.0 5.7e-23 81.5 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.1 CDF90046.1 - 1.3e-06 27.9 0.0 3.4e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.9 CDF90046.1 - 3.8e-06 26.6 0.0 8.8e-06 25.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 CDF90046.1 - 2.6e-05 24.3 0.4 0.00044 20.3 0.0 3.0 2 1 0 2 2 2 1 AAA domain AAA_PrkA PF08298.6 CDF90046.1 - 7.4e-05 21.5 0.1 0.00034 19.4 0.0 2.0 2 0 0 2 2 2 1 PrkA AAA domain AAA_16 PF13191.1 CDF90046.1 - 0.0001 22.3 1.4 0.0027 17.7 0.0 3.4 3 0 0 3 3 3 1 AAA ATPase domain AAA_17 PF13207.1 CDF90046.1 - 0.00028 21.6 1.6 0.0014 19.4 0.0 3.1 3 0 0 3 3 3 1 AAA domain RuvB_N PF05496.7 CDF90046.1 - 0.00088 18.3 0.0 0.011 14.8 0.0 2.3 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 CDF90046.1 - 0.0023 17.8 0.1 0.011 15.6 0.0 2.3 3 0 0 3 3 1 1 AAA domain SKI PF01202.17 CDF90046.1 - 0.0075 16.1 1.1 0.024 14.5 0.0 2.5 2 0 0 2 2 2 1 Shikimate kinase RNA_helicase PF00910.17 CDF90046.1 - 0.011 15.9 0.0 0.22 11.7 0.0 2.7 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.1 CDF90046.1 - 0.041 14.2 0.0 0.041 14.2 0.0 3.6 4 0 0 4 4 3 0 AAA domain DUF258 PF03193.11 CDF90046.1 - 0.051 12.7 0.2 0.15 11.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function, DUF258 IstB_IS21 PF01695.12 CDF90046.1 - 0.052 12.9 0.0 0.13 11.6 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Aldedh PF00171.17 CDF90047.1 - 4.9e-162 539.4 0.0 5.6e-162 539.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family zf-UBR PF02207.15 CDF90048.1 - 1.3e-12 47.2 9.4 1.3e-12 47.2 6.5 2.6 2 1 1 3 3 3 1 Putative zinc finger in N-recognin (UBR box) PHD PF00628.24 CDF90048.1 - 4e-06 26.4 6.5 4e-06 26.4 4.5 2.8 2 1 0 2 2 2 1 PHD-finger DUF3643 PF12356.3 CDF90048.1 - 0.072 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3643) MCM PF00493.18 CDF90049.1 - 3.5e-139 463.2 0.1 4.9e-139 462.7 0.1 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM2_N PF12619.3 CDF90049.1 - 7.9e-29 100.6 30.7 7.9e-29 100.6 21.3 3.8 5 0 0 5 5 5 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.1 CDF90049.1 - 5.6e-14 52.6 0.0 1.4e-13 51.4 0.0 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 CDF90049.1 - 1.7e-09 37.1 0.0 4e-07 29.3 0.0 2.5 1 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 CDF90049.1 - 1.7e-07 31.0 0.0 4.9e-07 29.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 CDF90049.1 - 0.00024 20.7 0.0 0.0022 17.5 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 CDF90049.1 - 0.0015 18.0 0.1 0.0093 15.4 0.1 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA PF00004.24 CDF90049.1 - 0.014 15.6 0.0 0.045 13.9 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Nol1_Nop2_Fmu PF01189.12 CDF90050.1 - 7.5e-77 258.4 0.0 7.6e-60 202.6 0.0 3.1 1 1 1 2 2 2 2 NOL1/NOP2/sun family FtsJ PF01728.14 CDF90050.1 - 0.0024 17.8 0.0 0.0099 15.8 0.0 2.0 2 0 0 2 2 2 1 FtsJ-like methyltransferase DGF-1_5 PF11038.3 CDF90050.1 - 0.019 14.2 0.0 0.032 13.4 0.0 1.3 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi region 5 DUF3361 PF11841.3 CDF90051.1 - 0.014 15.1 0.7 0.016 14.9 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3361) Prefoldin_2 PF01920.15 CDF90051.1 - 0.17 11.6 2.6 0.26 11.0 1.8 1.2 1 0 0 1 1 1 0 Prefoldin subunit zf-CCHC_4 PF14392.1 CDF90051.1 - 0.23 11.1 2.0 0.4 10.3 1.4 1.4 1 0 0 1 1 1 0 Zinc knuckle HisKA PF00512.20 CDF90051.1 - 0.56 10.2 3.5 0.46 10.5 0.9 1.9 1 1 1 2 2 2 0 His Kinase A (phospho-acceptor) domain LSM PF01423.17 CDF90052.1 - 7.9e-17 60.5 0.3 1.1e-16 60.1 0.2 1.2 1 0 0 1 1 1 1 LSM domain GDI PF00996.13 CDF90053.1 - 4.4e-214 710.7 0.1 5.2e-214 710.4 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.1 CDF90053.1 - 0.013 15.5 0.0 0.027 14.4 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DAO PF01266.19 CDF90053.1 - 0.15 10.9 0.0 2.1 7.1 0.0 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase ABC_tran PF00005.22 CDF90054.1 - 2.3e-22 79.7 0.0 2.5e-13 50.4 0.0 2.6 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 CDF90054.1 - 5.2e-05 23.3 5.3 0.0062 16.5 0.0 3.0 2 1 1 3 3 3 2 AAA domain SbcCD_C PF13558.1 CDF90054.1 - 0.0016 18.2 0.2 0.24 11.3 0.0 2.7 3 0 0 3 3 3 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.1 CDF90054.1 - 0.035 13.6 0.0 0.066 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.1 CDF90054.1 - 0.05 13.5 0.0 0.21 11.5 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.1 CDF90054.1 - 0.092 12.8 0.1 1.3 9.1 0.0 2.6 2 1 0 2 2 2 0 AAA domain Miro PF08477.8 CDF90054.1 - 0.1 13.0 0.0 0.19 12.2 0.0 1.4 1 0 0 1 1 1 0 Miro-like protein Aminotran_1_2 PF00155.16 CDF90055.1 - 1.3e-71 241.5 0.0 1.5e-71 241.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 CDF90055.1 - 0.002 16.9 0.0 0.0032 16.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 CDF90055.1 - 0.037 13.1 0.0 0.05 12.7 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Cofilin_ADF PF00241.15 CDF90056.1 - 2.3e-06 27.5 0.0 2.7e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Cys_Met_Meta_PP PF01053.15 CDF90056.1 - 0.052 11.8 0.0 0.065 11.5 0.0 1.1 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Ribosomal_S13_N PF08069.7 CDF90057.1 - 9e-29 99.1 0.3 1.7e-28 98.2 0.0 1.6 2 0 0 2 2 2 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.17 CDF90057.1 - 1.2e-23 82.6 0.1 4.2e-23 80.9 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein S15 PAX PF00292.13 CDF90057.1 - 0.11 12.1 0.0 0.54 9.9 0.0 1.9 2 0 0 2 2 2 0 'Paired box' domain Complex1_LYR PF05347.10 CDF90058.1 - 0.015 15.0 0.3 0.046 13.5 0.2 1.8 1 0 0 1 1 1 0 Complex 1 protein (LYR family) RPAP2_Rtr1 PF04181.8 CDF90059.1 - 1.8e-20 72.8 0.1 3.7e-20 71.8 0.1 1.5 1 0 0 1 1 1 1 Rtr1/RPAP2 family DUF747 PF05346.6 CDF90060.1 - 8.2e-90 301.2 18.0 1.2e-89 300.6 12.5 1.2 1 0 0 1 1 1 1 Eukaryotic membrane protein family COX15-CtaA PF02628.10 CDF90061.1 - 1.4e-103 345.8 3.6 1.7e-103 345.6 2.5 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein 7TMR-DISM_7TM PF07695.6 CDF90061.1 - 0.83 9.2 10.0 0.17 11.5 0.6 2.8 2 1 1 3 3 3 0 7TM diverse intracellular signalling Ferric_reduct PF01794.14 CDF90061.1 - 1.3 9.1 9.8 5.7 7.0 0.2 3.0 3 1 0 3 3 3 0 Ferric reductase like transmembrane component HhH-GPD PF00730.20 CDF90062.1 - 3.1e-12 46.7 0.0 4.9e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein TetR_C_8 PF14278.1 CDF90062.1 - 0.044 14.1 0.1 0.18 12.2 0.0 2.0 2 0 0 2 2 2 0 Transcriptional regulator C-terminal region Asp_protease PF09668.5 CDF90063.1 - 3.6e-52 175.1 0.1 5.1e-52 174.6 0.1 1.2 1 0 0 1 1 1 1 Aspartyl protease UBA PF00627.26 CDF90063.1 - 7e-10 38.4 0.2 3e-09 36.4 0.0 2.1 2 0 0 2 2 2 1 UBA/TS-N domain Asp_protease_2 PF13650.1 CDF90063.1 - 2.4e-09 37.5 0.1 4.8e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.15 CDF90063.1 - 3e-09 36.7 0.1 1.1e-08 34.9 0.0 1.9 2 1 0 2 2 2 1 Retroviral aspartyl protease gag-asp_proteas PF13975.1 CDF90063.1 - 3.7e-07 29.8 0.0 1.3e-06 28.0 0.0 1.9 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease RVP_2 PF08284.6 CDF90063.1 - 2.6e-05 24.1 0.0 4.4e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease RuvA_C PF07499.8 CDF90063.1 - 0.062 13.4 0.1 0.16 12.1 0.1 1.7 1 0 0 1 1 1 0 RuvA, C-terminal domain Y_phosphatase2 PF03162.8 CDF90064.1 - 8e-56 187.9 1.9 1e-55 187.6 1.3 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family BSD PF03909.12 CDF90065.1 - 2.1e-17 62.6 0.9 8.5e-17 60.6 0.3 2.4 2 0 0 2 2 2 1 BSD domain UCH PF00443.24 CDF90066.1 - 4.4e-70 235.8 2.7 6.7e-70 235.2 0.2 2.2 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CDF90066.1 - 5.7e-28 98.1 0.1 1.4e-27 96.9 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.15 CDF90066.1 - 0.00011 22.5 0.0 0.00027 21.2 0.0 1.8 1 0 0 1 1 1 1 Rhodanese-like domain Zn-ribbon_8 PF09723.5 CDF90066.1 - 0.012 15.4 2.2 3.6 7.6 0.7 2.8 2 0 0 2 2 2 0 Zinc ribbon domain Rubredoxin PF00301.15 CDF90066.1 - 0.12 12.2 2.6 0.75 9.7 0.2 2.5 2 0 0 2 2 2 0 Rubredoxin MogR_DNAbind PF12181.3 CDF90066.1 - 0.17 11.6 3.7 2 8.1 0.1 2.5 1 1 1 2 2 2 0 DNA binding domain of the motility gene repressor (MogR) zf-MIZ PF02891.15 CDF90066.1 - 0.6 9.6 6.5 0.15 11.5 0.2 2.6 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger DUF1068 PF06364.7 CDF90067.1 - 0.086 12.4 0.8 0.12 12.0 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1068) Acetyltransf_1 PF00583.19 CDF90068.1 - 9.2e-10 38.4 0.0 1.4e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CDF90068.1 - 1.4e-09 37.9 0.0 2.9e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 CDF90068.1 - 3.5e-05 23.7 0.0 5e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 CDF90068.1 - 0.011 15.6 0.0 0.015 15.2 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CDF90068.1 - 0.024 14.7 0.0 0.035 14.2 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.5 CDF90068.1 - 0.083 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein FTR1 PF03239.9 CDF90069.1 - 9.6e-93 310.4 6.8 1.2e-92 310.2 4.7 1.1 1 0 0 1 1 1 1 Iron permease FTR1 family LSM PF01423.17 CDF90070.1 - 9.4e-15 53.9 0.1 1.1e-14 53.7 0.0 1.1 1 0 0 1 1 1 1 LSM domain PAP2 PF01569.16 CDF90071.1 - 5.7e-07 29.2 7.3 5.7e-07 29.2 5.0 2.7 2 1 0 2 2 2 1 PAP2 superfamily DUF2516 PF10724.4 CDF90071.1 - 0.24 11.4 2.3 5.8 6.9 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2516) Glyco_transf_20 PF00982.16 CDF90073.1 - 4.5e-140 467.2 0.7 8.4e-140 466.3 0.5 1.4 1 1 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.11 CDF90073.1 - 1.1e-81 273.2 0.0 1.8e-81 272.5 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase Glycos_transf_1 PF00534.15 CDF90073.1 - 0.018 14.4 0.0 0.062 12.7 0.0 2.0 1 1 0 1 1 1 0 Glycosyl transferases group 1 RRF PF01765.14 CDF90073.1 - 0.046 13.1 0.0 0.15 11.5 0.0 1.8 1 0 0 1 1 1 0 Ribosome recycling factor Cohesin_load PF10345.4 CDF90074.1 - 2.7e-101 339.6 22.5 3.3e-101 339.3 15.6 1.0 1 0 0 1 1 1 1 Cohesin loading factor TBP PF00352.16 CDF90075.1 - 6.6e-70 230.5 0.1 4e-35 119.0 0.0 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.3 CDF90075.1 - 0.00013 21.9 0.2 0.61 10.1 0.0 2.6 2 1 1 3 3 3 2 Domain of unknown function (DUF3378) TIP120 PF08623.5 CDF90076.1 - 0.014 14.9 2.1 0.2 11.2 0.3 2.3 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) CCDC92 PF14916.1 CDF90076.1 - 0.36 10.4 5.6 0.5 9.9 2.3 2.5 3 1 0 3 3 3 0 Coiled-coil domain of unknown function U1snRNP70_N PF12220.3 CDF90076.1 - 3.6 7.9 8.1 0.78 10.1 2.0 2.4 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Metallophos PF00149.23 CDF90077.1 - 1.3e-40 138.9 0.2 1.6e-40 138.6 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 CDF90077.1 - 0.00012 21.9 0.0 0.00018 21.3 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain AAA_25 PF13481.1 CDF90078.1 - 3.4e-09 36.3 1.5 2.4e-06 27.0 0.0 3.1 1 1 1 2 2 2 2 AAA domain RecA PF00154.16 CDF90078.1 - 1.1e-05 24.6 0.0 1.5e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein Rad51 PF08423.6 CDF90078.1 - 4.2e-05 22.5 0.0 0.00018 20.4 0.0 1.9 2 0 0 2 2 2 1 Rad51 AAA_17 PF13207.1 CDF90078.1 - 8.9e-05 23.2 0.0 0.00012 22.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 CDF90078.1 - 0.00019 21.6 0.0 0.00037 20.7 0.0 1.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.1 CDF90078.1 - 0.00042 19.9 0.0 0.00069 19.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 CDF90078.1 - 0.00054 19.1 0.0 0.00098 18.2 0.0 1.4 1 0 0 1 1 1 1 KaiC AAA_18 PF13238.1 CDF90078.1 - 0.00076 19.7 0.0 0.0014 18.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CDF90078.1 - 0.0059 16.7 0.3 0.062 13.4 0.1 2.6 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.9 CDF90078.1 - 0.0067 16.1 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Corona_nucleoca PF00937.13 CDF90078.1 - 0.0068 15.3 3.5 0.0091 14.9 2.4 1.1 1 0 0 1 1 1 1 Coronavirus nucleocapsid protein IstB_IS21 PF01695.12 CDF90078.1 - 0.016 14.6 0.3 0.038 13.3 0.1 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_19 PF13245.1 CDF90078.1 - 0.031 14.0 0.3 0.031 14.0 0.2 2.5 3 0 0 3 3 3 0 Part of AAA domain AAA_16 PF13191.1 CDF90078.1 - 0.055 13.4 0.1 0.16 11.9 0.1 2.0 1 1 0 1 1 1 0 AAA ATPase domain RuvB_N PF05496.7 CDF90078.1 - 0.066 12.2 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus NACHT PF05729.7 CDF90078.1 - 0.093 12.3 0.0 18 4.9 0.0 2.7 1 1 2 3 3 3 0 NACHT domain Spc42p PF11544.3 CDF90081.1 - 2.1e-25 88.4 1.8 2.1e-25 88.4 1.2 2.5 2 0 0 2 2 2 1 Spindle pole body component Spc42p DivIVA PF05103.8 CDF90081.1 - 0.37 10.8 10.0 1.6 8.7 1.3 2.6 2 1 0 2 2 2 0 DivIVA protein FliD_N PF02465.13 CDF90081.1 - 1.8 8.9 4.6 1 9.7 0.3 2.3 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF972 PF06156.8 CDF90081.1 - 7.2 7.0 11.6 21 5.5 3.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF972) Exonuc_VII_L PF02601.10 CDF90081.1 - 7.6 5.6 14.2 1.7 7.7 5.1 2.1 1 1 1 2 2 2 0 Exonuclease VII, large subunit p450 PF00067.17 CDF90082.1 - 8.6e-54 182.7 0.0 1.1e-53 182.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BUD22 PF09073.5 CDF90083.1 - 4.5e-82 276.4 31.5 6.4e-82 275.9 21.9 1.2 1 0 0 1 1 1 1 BUD22 CTP_transf_1 PF01148.15 CDF90084.1 - 0.00024 20.8 15.5 0.00024 20.8 10.8 4.3 1 1 1 2 2 2 1 Cytidylyltransferase family CLU PF13236.1 CDF90085.1 - 7.3e-75 251.1 1.1 9.9e-75 250.7 0.0 1.8 2 0 0 2 2 2 1 Clustered mitochondria eIF3_p135 PF12807.2 CDF90085.1 - 7.3e-29 100.8 0.3 4.6e-19 68.9 0.0 3.4 4 0 0 4 4 4 2 Translation initiation factor eIF3 subunit 135 CLU_N PF15044.1 CDF90085.1 - 8.5e-12 45.0 0.6 4.2e-11 42.8 0.1 2.6 2 0 0 2 2 2 1 Mitochondrial function, CLU-N-term TPR_12 PF13424.1 CDF90085.1 - 6.1e-07 29.2 2.7 0.0025 17.7 0.0 4.3 3 1 1 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.1 CDF90085.1 - 0.053 13.4 0.1 1.4 8.9 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Snf7 PF03357.16 CDF90086.1 - 8.1e-32 109.9 13.7 8.1e-32 109.9 9.5 1.9 2 0 0 2 2 2 1 Snf7 PAS_7 PF12860.2 CDF90086.1 - 0.015 15.3 5.4 0.27 11.2 0.0 3.0 3 1 1 4 4 4 0 PAS fold PilJ PF13675.1 CDF90086.1 - 0.25 11.6 6.8 0.29 11.4 0.2 3.0 2 1 1 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Opi1 PF08618.5 CDF90087.1 - 6.2e-30 104.4 10.5 5.6e-23 81.5 3.9 2.6 1 1 1 2 2 2 2 Transcription factor Opi1 CENP-B_dimeris PF09026.5 CDF90087.1 - 9.7e-05 22.5 5.8 0.11 12.8 0.3 2.4 2 0 0 2 2 2 2 Centromere protein B dimerisation domain DUF4611 PF15387.1 CDF90087.1 - 0.009 16.1 1.6 0.009 16.1 1.1 3.0 3 0 0 3 3 3 2 Domain of unknown function (DUF4611) TLP-20 PF06088.6 CDF90087.1 - 0.058 13.0 8.8 1.1 8.8 2.6 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) PFEMP PF03011.10 CDF90087.1 - 7.5 6.8 17.4 1 9.7 1.9 2.6 2 1 0 2 2 2 0 PFEMP DBL domain Nucleoplasmin PF03066.10 CDF90087.1 - 8.4 5.8 18.8 1.9 7.9 1.4 2.4 2 0 0 2 2 2 0 Nucleoplasmin DUF848 PF05852.6 CDF90088.1 - 0.28 11.0 4.0 0.11 12.2 1.0 1.6 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Adap_comp_sub PF00928.16 CDF90089.1 - 7e-60 202.3 0.5 9.2e-60 201.9 0.3 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Pterin_4a PF01329.14 CDF90090.1 - 7.8e-25 86.4 0.1 8.7e-25 86.3 0.1 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Nfu_N PF08712.6 CDF90091.1 - 1.9e-25 88.2 0.0 4e-25 87.2 0.0 1.5 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.12 CDF90091.1 - 8.2e-22 76.7 0.1 1.4e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 NifU-like domain YojJ PF10372.4 CDF90091.1 - 0.0013 18.5 1.6 0.0023 17.7 1.1 1.4 1 0 0 1 1 1 1 Bacterial membrane-spanning protein N-terminus Sigma70_r1_2 PF00140.15 CDF90091.1 - 0.094 12.4 0.4 0.26 10.9 0.3 1.8 1 0 0 1 1 1 0 Sigma-70 factor, region 1.2 Lung_7-TM_R PF06814.8 CDF90092.1 - 3e-81 272.6 23.5 3.8e-81 272.2 16.3 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor DUF4435 PF14491.1 CDF90092.1 - 0.017 14.9 0.6 0.017 14.9 0.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4435) DUF1688 PF07958.6 CDF90093.1 - 8.2e-164 545.1 0.0 9.2e-164 544.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) Ribosomal_S10 PF00338.17 CDF90094.1 - 7.6e-28 96.2 0.5 8.9e-28 95.9 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e DUF4075 PF13294.1 CDF90094.1 - 0.091 12.8 0.9 0.17 11.9 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4075) YchF-GTPase_C PF06071.8 CDF90095.1 - 2.5e-30 104.0 0.0 5e-30 103.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.18 CDF90095.1 - 7.6e-14 51.6 0.0 1.9e-13 50.3 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.16 CDF90095.1 - 5.1e-06 26.2 0.0 1e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.13 CDF90095.1 - 0.00063 19.0 0.0 0.0011 18.2 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B OTU PF02338.14 CDF90096.1 - 8.1e-21 74.8 0.1 8.1e-21 74.8 0.1 1.9 3 0 0 3 3 3 1 OTU-like cysteine protease Peptidase_C65 PF10275.4 CDF90096.1 - 0.00012 21.4 3.9 0.00022 20.6 0.1 2.5 2 1 0 2 2 2 1 Peptidase C65 Otubain DUF4589 PF15252.1 CDF90096.1 - 0.57 9.9 5.0 0.87 9.3 3.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4589) Zn_clus PF00172.13 CDF90097.1 - 6e-09 35.6 7.6 1.2e-08 34.6 5.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 7tm_6 PF02949.15 CDF90097.1 - 0.03 13.1 1.2 1.8 7.3 0.0 2.2 2 0 0 2 2 2 0 7tm Odorant receptor UDPGP PF01704.13 CDF90098.1 - 4.4e-192 638.2 0.0 5.3e-192 637.9 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase zf-RING_2 PF13639.1 CDF90099.1 - 6.9e-11 41.8 4.7 1.4e-10 40.7 3.3 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 CDF90099.1 - 8.6e-10 38.5 2.7 1.7e-09 37.6 1.9 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-RING_5 PF14634.1 CDF90099.1 - 1.7e-08 34.0 2.7 3.6e-08 33.0 1.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.1 CDF90099.1 - 7.2e-07 28.7 2.3 1.5e-06 27.7 1.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDF90099.1 - 3.5e-06 26.5 4.2 7.4e-06 25.5 2.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDF90099.1 - 5.8e-06 26.2 2.5 5.8e-06 26.2 1.7 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 CDF90099.1 - 0.0005 19.8 1.1 0.001 18.8 0.8 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.1 CDF90099.1 - 0.0006 19.4 0.6 0.0016 18.1 0.4 1.7 1 0 0 1 1 1 1 RING-type zinc-finger FANCL_C PF11793.3 CDF90099.1 - 0.0047 16.8 1.5 0.013 15.4 1.0 1.8 1 1 0 1 1 1 1 FANCL C-terminal domain zf-C3HC4_4 PF15227.1 CDF90099.1 - 1.1 9.1 4.4 1.2 9.0 1.6 2.2 2 0 0 2 2 1 0 zinc finger of C3HC4-type, RING RINGv PF12906.2 CDF90099.1 - 4.4 7.4 6.1 0.88 9.6 1.7 1.8 2 0 0 2 2 2 0 RING-variant domain WHIM1 PF15612.1 CDF90100.1 - 3.6e-05 23.4 0.0 0.00012 21.8 0.0 2.0 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 Pkinase PF00069.20 CDF90101.1 - 3.8e-70 236.0 0.0 5.6e-70 235.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF90101.1 - 9.3e-38 129.7 0.0 1.4e-37 129.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF90101.1 - 0.0032 16.4 0.1 0.017 14.0 0.0 2.1 2 1 0 2 2 2 1 Kinase-like ABC1 PF03109.11 CDF90101.1 - 0.036 14.0 0.5 0.28 11.1 0.0 2.5 2 1 1 3 3 3 0 ABC1 family APH PF01636.18 CDF90101.1 - 0.073 12.7 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family SH3BGR PF04908.10 CDF90104.1 - 0.018 14.9 0.0 0.13 12.2 0.0 2.5 2 0 0 2 2 2 0 SH3-binding, glutamic acid-rich protein DUF2606 PF10794.4 CDF90104.1 - 0.12 11.8 0.8 1.2 8.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2606) Ferric_reduct PF01794.14 CDF90106.1 - 1.9e-17 63.4 13.7 1.9e-17 63.4 9.5 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.7 CDF90106.1 - 1.4e-13 51.0 0.0 2.1e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 CDF90106.1 - 1.3e-08 34.6 0.1 2.4e-08 33.8 0.1 1.4 1 0 0 1 1 1 1 FAD-binding domain G_glu_transpept PF01019.16 CDF90107.1 - 4.8e-127 424.5 0.0 5.4e-127 424.3 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase SRR1 PF07985.7 CDF90107.1 - 0.14 12.1 1.2 5.3 7.0 0.1 2.4 1 1 1 2 2 2 0 SRR1 Zn_clus PF00172.13 CDF90108.1 - 9.7e-08 31.8 9.1 2.2e-07 30.6 6.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.13 CDF90108.1 - 1.3e-07 30.7 3.1 1.6e-06 27.2 0.4 2.7 2 1 0 2 2 2 2 Fungal specific transcription factor domain OCD_Mu_crystall PF02423.10 CDF90109.1 - 2.5e-09 36.3 0.0 5.2e-09 35.3 0.0 1.4 1 1 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family ATG16 PF08614.6 CDF90110.1 - 0.00022 21.1 6.7 0.00022 21.1 4.6 1.5 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) bZIP_1 PF00170.16 CDF90110.1 - 0.014 15.3 0.9 0.014 15.3 0.6 3.1 2 2 0 3 3 3 0 bZIP transcription factor Gly_radical PF01228.16 CDF90110.1 - 0.025 14.9 1.1 0.043 14.1 0.7 1.5 1 1 0 1 1 1 0 Glycine radical bZIP_2 PF07716.10 CDF90110.1 - 0.031 14.1 0.5 0.031 14.1 0.4 3.5 3 1 1 4 4 4 0 Basic region leucine zipper Phage_Mu_Gam PF07352.7 CDF90110.1 - 0.055 12.9 4.1 0.038 13.4 1.1 2.0 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein NUDE_C PF04880.8 CDF90110.1 - 0.087 13.1 1.3 0.17 12.2 0.6 1.7 1 1 0 1 1 1 0 NUDE protein, C-terminal conserved region IncA PF04156.9 CDF90110.1 - 0.088 12.4 16.2 0.18 11.3 11.2 1.5 1 1 0 1 1 1 0 IncA protein DUF904 PF06005.7 CDF90110.1 - 0.096 12.9 18.8 0.5 10.6 1.1 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF904) Tropomyosin PF00261.15 CDF90110.1 - 0.28 10.2 13.3 0.32 10.0 8.8 1.3 1 1 0 1 1 1 0 Tropomyosin Fib_alpha PF08702.5 CDF90110.1 - 0.8 9.8 8.6 0.51 10.4 4.8 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DMPK_coil PF08826.5 CDF90110.1 - 0.93 9.4 7.1 2.9 7.8 0.5 2.7 2 1 0 2 2 2 0 DMPK coiled coil domain like Striatin PF08232.7 CDF90110.1 - 1.1 9.5 8.8 2.1 8.6 5.6 1.7 1 1 1 2 2 2 0 Striatin family V_ATPase_I PF01496.14 CDF90110.1 - 1.2 6.9 7.5 1.2 6.8 5.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF972 PF06156.8 CDF90110.1 - 2.9 8.2 13.5 0.32 11.3 4.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF972) PCRF PF03462.13 CDF90110.1 - 9.4 5.9 7.8 10 5.8 0.4 2.6 1 1 2 3 3 3 0 PCRF domain ABC1 PF03109.11 CDF90111.1 - 1.8e-32 111.8 0.0 3.6e-32 110.8 0.0 1.5 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.17 CDF90111.1 - 0.00019 20.8 0.0 0.0013 18.0 0.0 2.2 2 0 0 2 2 2 1 RIO1 family CotJA PF11007.3 CDF90111.1 - 0.033 13.8 0.3 20 4.9 0.0 3.8 4 0 0 4 4 4 0 Spore coat associated protein JA (CotJA) Mpv17_PMP22 PF04117.7 CDF90112.1 - 3.7e-25 87.3 2.6 8.6e-25 86.1 1.8 1.6 1 0 0 1 1 1 1 Mpv17 / PMP22 family PLDc PF00614.17 CDF90113.1 - 0.016 14.9 0.6 0.043 13.6 0.4 1.7 1 0 0 1 1 1 0 Phospholipase D Active site motif Zn_clus PF00172.13 CDF90114.1 - 6.2e-08 32.4 10.3 1.3e-07 31.4 7.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Protein_K PF12283.3 CDF90114.1 - 0.051 13.4 1.6 0.11 12.4 0.1 2.3 2 0 0 2 2 2 0 Bacteriophage protein K TP_methylase PF00590.15 CDF90116.1 - 3.8e-23 82.2 0.0 7.4e-23 81.3 0.0 1.5 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF4434 PF14488.1 CDF90116.1 - 0.0074 16.0 0.0 0.018 14.7 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4434) Clat_adaptor_s PF01217.15 CDF90117.1 - 9.1e-55 184.2 0.1 1.1e-54 184.0 0.1 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain HMG_box PF00505.14 CDF90118.1 - 0.084 13.1 0.3 0.14 12.4 0.2 1.3 1 0 0 1 1 1 0 HMG (high mobility group) box SNF2_N PF00176.18 CDF90119.1 - 1.3e-44 152.1 0.4 2.5e-44 151.2 0.3 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-RING_2 PF13639.1 CDF90119.1 - 6.6e-10 38.6 13.6 1.2e-09 37.8 7.7 2.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.1 CDF90119.1 - 2.3e-08 33.5 10.4 5.6e-08 32.3 5.5 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDF90119.1 - 3.3e-08 33.0 11.6 3.3e-08 33.0 8.0 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDF90119.1 - 1.4e-06 28.2 12.7 1.4e-06 28.2 8.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CDF90119.1 - 7.5e-06 25.7 9.3 2.6e-05 23.9 6.5 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.1 CDF90119.1 - 9.6e-05 22.0 11.6 9.6e-05 22.0 8.0 2.2 2 0 0 2 2 1 1 zinc-RING finger domain ResIII PF04851.10 CDF90119.1 - 0.00015 21.6 0.0 0.00015 21.6 0.0 2.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit zf-rbx1 PF12678.2 CDF90119.1 - 0.0012 18.9 10.5 0.0012 18.9 7.3 2.3 2 1 0 2 2 1 1 RING-H2 zinc finger Helicase_C PF00271.26 CDF90119.1 - 0.0033 17.2 0.0 0.008 16.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain UPF0154 PF03672.8 CDF90119.1 - 0.056 13.0 0.5 2.3 7.9 0.0 3.1 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0154) zf-P11 PF03854.9 CDF90119.1 - 0.075 12.5 7.1 0.29 10.6 4.9 2.1 1 0 0 1 1 1 0 P-11 zinc finger zf-RING_4 PF14570.1 CDF90119.1 - 0.14 11.7 7.2 0.4 10.3 5.0 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Apc11 PF12861.2 CDF90119.1 - 0.18 11.6 4.3 0.52 10.1 3.0 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.1 CDF90119.1 - 0.18 11.3 5.8 0.46 10.0 4.0 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 PDGF_N PF04692.8 CDF90119.1 - 0.38 11.2 4.8 6.1 7.4 0.6 3.3 2 0 0 2 2 2 0 Platelet-derived growth factor, N terminal region zf-RING_UBOX PF13445.1 CDF90119.1 - 5.5 6.7 16.2 0.4 10.4 6.7 2.5 2 0 0 2 2 2 0 RING-type zinc-finger Pkinase PF00069.20 CDF90120.1 - 1.9e-57 194.4 0.0 2.9e-57 193.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF90120.1 - 3.2e-24 85.4 0.0 8.6e-24 83.9 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF90120.1 - 3.1e-06 26.3 0.0 0.0033 16.4 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.9 CDF90120.1 - 0.0012 17.9 0.0 0.0027 16.8 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family HNF-1_N PF04814.8 CDF90120.1 - 5.2 7.1 7.8 0.66 10.0 0.5 2.5 3 0 0 3 3 3 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus ABC_tran PF00005.22 CDF90121.1 - 6.1e-45 152.8 0.1 4.4e-22 78.8 0.0 4.2 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 CDF90121.1 - 1.4e-17 64.5 0.2 2.2e-05 24.5 0.0 4.4 3 1 0 3 3 3 3 AAA domain SMC_N PF02463.14 CDF90121.1 - 2e-16 59.9 0.0 1e-06 28.1 0.0 3.7 2 2 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 CDF90121.1 - 6e-11 43.0 1.6 0.00048 20.5 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.1 CDF90121.1 - 1.9e-09 36.9 0.0 0.0024 17.3 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF258 PF03193.11 CDF90121.1 - 1.2e-08 34.3 0.1 0.00015 21.0 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_17 PF13207.1 CDF90121.1 - 8.4e-08 33.0 0.0 0.0085 16.9 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 CDF90121.1 - 1.2e-07 31.9 0.0 0.0023 18.0 0.0 3.5 4 1 0 4 4 2 2 AAA domain AAA_28 PF13521.1 CDF90121.1 - 2.7e-07 30.6 0.1 0.0028 17.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.18 CDF90121.1 - 3.6e-07 30.1 0.0 3.1e-05 23.8 0.0 2.9 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.18 CDF90121.1 - 5.6e-07 29.5 0.0 0.0042 17.0 0.0 3.1 3 0 0 3 3 2 2 50S ribosome-binding GTPase HEAT_2 PF13646.1 CDF90121.1 - 1.3e-06 28.6 1.0 0.0035 17.5 0.5 3.0 2 1 1 3 3 2 2 HEAT repeats AAA_33 PF13671.1 CDF90121.1 - 2.7e-06 27.3 0.0 0.054 13.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain Miro PF08477.8 CDF90121.1 - 3.2e-06 27.6 0.0 0.034 14.6 0.0 2.9 2 0 0 2 2 2 2 Miro-like protein AAA_10 PF12846.2 CDF90121.1 - 4.9e-06 26.1 0.0 0.27 10.6 0.0 3.5 4 0 0 4 4 3 2 AAA-like domain AAA PF00004.24 CDF90121.1 - 5.5e-06 26.6 0.0 0.6 10.3 0.0 4.3 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.1 CDF90121.1 - 9.4e-06 25.4 0.0 0.023 14.6 0.0 3.4 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit ArgK PF03308.11 CDF90121.1 - 9.6e-06 24.5 0.1 0.05 12.3 0.0 2.5 2 0 0 2 2 2 2 ArgK protein RNA_helicase PF00910.17 CDF90121.1 - 1.5e-05 25.1 0.0 0.19 11.9 0.0 3.0 2 0 0 2 2 2 2 RNA helicase AAA_18 PF13238.1 CDF90121.1 - 2e-05 24.9 0.1 0.034 14.4 0.0 3.2 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.1 CDF90121.1 - 2.5e-05 23.5 0.1 0.78 8.7 0.1 3.8 3 1 1 4 4 3 1 AAA ATPase domain MobB PF03205.9 CDF90121.1 - 7.2e-05 22.5 0.0 0.29 10.8 0.0 2.9 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B ParcG PF10274.4 CDF90121.1 - 0.00021 21.2 0.4 1.8 8.4 0.0 3.1 2 1 1 3 3 3 2 Parkin co-regulated protein AAA_16 PF13191.1 CDF90121.1 - 0.00021 21.3 0.6 0.48 10.3 0.0 3.9 4 1 0 4 4 4 1 AAA ATPase domain Arch_ATPase PF01637.13 CDF90121.1 - 0.00024 20.8 0.0 0.41 10.3 0.0 2.9 2 0 0 2 2 2 1 Archaeal ATPase HEAT PF02985.17 CDF90121.1 - 0.00046 20.0 0.2 2.2 8.5 0.0 4.3 4 0 0 4 4 3 1 HEAT repeat AAA_14 PF13173.1 CDF90121.1 - 0.0007 19.4 0.0 2.5 7.9 0.0 3.2 3 0 0 3 3 2 2 AAA domain UME PF08064.8 CDF90121.1 - 0.00073 19.4 0.7 0.014 15.3 0.2 2.6 1 1 1 2 2 2 1 UME (NUC010) domain MutS_V PF00488.16 CDF90121.1 - 0.00084 18.8 0.0 0.23 10.8 0.0 2.4 2 0 0 2 2 2 1 MutS domain V CLASP_N PF12348.3 CDF90121.1 - 0.0011 18.3 0.6 0.014 14.7 0.4 2.4 1 1 1 2 2 2 1 CLASP N terminal AAA_13 PF13166.1 CDF90121.1 - 0.0014 17.1 6.9 2.2 6.6 0.0 4.3 3 1 0 4 4 4 2 AAA domain HEAT_EZ PF13513.1 CDF90121.1 - 0.0015 18.9 4.8 2.5 8.7 0.0 4.6 6 0 0 6 6 3 1 HEAT-like repeat NACHT PF05729.7 CDF90121.1 - 0.0019 17.9 0.1 0.76 9.4 0.0 2.5 2 0 0 2 2 2 1 NACHT domain MMS19_C PF12460.3 CDF90121.1 - 0.0019 16.9 0.3 0.045 12.4 0.0 2.8 3 0 0 3 3 3 1 RNAPII transcription regulator C-terminal AAA_30 PF13604.1 CDF90121.1 - 0.0026 17.3 0.1 3 7.3 0.0 3.4 3 0 0 3 3 3 1 AAA domain PduV-EutP PF10662.4 CDF90121.1 - 0.0028 17.1 0.0 0.31 10.5 0.0 3.0 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation cobW PF02492.14 CDF90121.1 - 0.0044 16.4 1.7 1.2 8.5 0.0 3.2 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.1 CDF90121.1 - 0.0076 15.6 0.0 1.9 7.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain Adaptin_N PF01602.15 CDF90121.1 - 0.016 13.5 3.0 0.035 12.4 2.1 1.6 1 1 0 1 1 1 0 Adaptin N terminal region Mg_chelatase PF01078.16 CDF90121.1 - 0.017 14.2 0.2 1.2 8.3 0.0 3.2 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.7 CDF90121.1 - 0.027 13.5 0.0 5.5 6.0 0.0 2.7 2 0 0 2 2 2 0 Zeta toxin Septin PF00735.13 CDF90121.1 - 0.037 13.0 0.5 1.2 8.0 0.0 2.8 3 0 0 3 3 3 0 Septin DUF87 PF01935.12 CDF90121.1 - 0.041 13.6 7.0 0.38 10.5 0.0 4.0 5 0 0 5 5 3 0 Domain of unknown function DUF87 AAA_19 PF13245.1 CDF90121.1 - 0.054 13.2 0.1 5.4 6.8 0.0 2.9 3 0 0 3 3 2 0 Part of AAA domain ATP_bind_1 PF03029.12 CDF90121.1 - 0.069 12.6 0.2 8.1 5.8 0.0 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein FtsK_SpoIIIE PF01580.13 CDF90121.1 - 0.085 12.3 0.2 2.2 7.6 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family PLA2_B PF01735.13 CDF90122.1 - 5e-80 269.0 7.5 7.5e-64 215.6 2.4 3.7 2 1 0 2 2 2 2 Lysophospholipase catalytic domain Patatin PF01734.17 CDF90122.1 - 0.00018 21.5 0.0 0.0006 19.7 0.0 2.1 1 1 0 1 1 1 1 Patatin-like phospholipase LIM PF00412.17 CDF90122.1 - 0.037 14.0 0.6 0.075 13.1 0.4 1.5 1 0 0 1 1 1 0 LIM domain EF-hand_6 PF13405.1 CDF90123.1 - 4.5e-06 26.0 2.4 0.04 13.8 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.27 CDF90123.1 - 6.3e-05 21.9 1.4 0.0092 15.2 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.1 CDF90123.1 - 0.00013 22.0 2.4 0.00013 22.0 1.7 2.5 2 2 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.1 CDF90123.1 - 0.0026 17.3 0.4 0.82 9.3 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair UPF0052 PF01933.13 CDF90124.1 - 2e-65 221.0 0.0 2.8e-65 220.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 HAD PF12710.2 CDF90125.1 - 3e-16 60.1 0.3 4.5e-16 59.5 0.2 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.7 CDF90125.1 - 2.5e-09 36.6 0.1 3.5e-09 36.1 0.1 1.2 1 0 0 1 1 1 1 Putative Phosphatase HAD_2 PF13419.1 CDF90125.1 - 5.2e-05 23.5 0.0 0.00042 20.5 0.0 2.3 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase UMPH-1 PF05822.7 CDF90125.1 - 0.0036 16.6 0.1 0.0076 15.5 0.0 1.6 2 1 0 2 2 2 1 Pyrimidine 5'-nucleotidase (UMPH-1) Hydrolase PF00702.21 CDF90125.1 - 0.015 15.7 0.2 1.6 9.0 0.0 2.9 2 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase Iso_dh PF00180.15 CDF90126.1 - 3.2e-71 240.0 0.0 3.8e-71 239.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase ALS_ss_C PF10369.4 CDF90127.1 - 2.1e-18 65.7 0.0 1.2e-17 63.3 0.0 2.2 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.20 CDF90127.1 - 2.2e-11 42.9 0.1 4.6e-11 41.9 0.1 1.6 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.1 CDF90127.1 - 4.7e-09 35.9 0.0 8.1e-09 35.1 0.0 1.4 1 0 0 1 1 1 1 ACT domain Ribosomal_L27 PF01016.14 CDF90128.1 - 3.8e-30 103.5 0.2 6.5e-30 102.7 0.2 1.4 1 0 0 1 1 1 1 Ribosomal L27 protein 3H PF02829.9 CDF90128.1 - 0.046 13.7 2.1 0.22 11.5 0.6 2.4 2 0 0 2 2 2 0 3H domain DUF1325 PF07039.6 CDF90129.1 - 5.5e-32 110.0 0.0 7.8e-32 109.6 0.0 1.2 1 0 0 1 1 1 1 SGF29 tudor-like domain DUF4537 PF15057.1 CDF90129.1 - 0.032 14.0 0.0 0.068 12.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) RRM_1 PF00076.17 CDF90130.1 - 3.3e-59 196.4 0.1 6.7e-21 73.7 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF90130.1 - 2.9e-35 120.0 0.0 7.9e-11 41.7 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF90130.1 - 5.4e-23 80.5 0.0 5.6e-09 35.7 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 CDF90130.1 - 0.011 15.4 0.1 4.8 6.9 0.0 3.6 3 2 0 3 3 3 0 Limkain b1 DUF2015 PF09435.5 CDF90131.1 - 5.3e-39 132.9 0.1 5.8e-39 132.8 0.1 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) CcmD PF04995.9 CDF90131.1 - 0.12 12.1 0.4 0.2 11.4 0.3 1.4 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) DUF2036 PF09724.4 CDF90132.1 - 1.3e-78 264.4 0.1 1.5e-78 264.2 0.1 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2036) Mito_carr PF00153.22 CDF90133.1 - 6.7e-52 173.1 1.0 3.8e-19 68.1 0.0 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein Aminotran_5 PF00266.14 CDF90134.1 - 1.3e-97 326.9 0.0 1.7e-97 326.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 CDF90134.1 - 3e-06 26.5 0.1 1.4e-05 24.3 0.0 2.0 3 0 0 3 3 3 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 CDF90134.1 - 4.5e-06 26.0 0.0 6.5e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Pyridoxal_deC PF00282.14 CDF90134.1 - 0.0019 16.7 0.0 0.003 16.0 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Iso_dh PF00180.15 CDF90135.1 - 2.8e-131 437.6 0.0 3.2e-131 437.4 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Ribosomal_L30 PF00327.15 CDF90136.1 - 7.9e-12 44.5 2.0 8.6e-12 44.4 0.4 1.9 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e DNA_pol_viral_C PF00336.13 CDF90136.1 - 0.042 13.1 0.0 0.075 12.2 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain DnaJ PF00226.26 CDF90137.1 - 1.2e-23 82.6 1.2 1.9e-23 81.9 0.8 1.3 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 CDF90137.1 - 1.9e-23 82.1 1.2 4.3e-20 71.3 0.0 2.6 2 1 0 2 2 2 2 DnaJ C terminal domain DKCLD PF08068.7 CDF90138.1 - 2.5e-29 100.9 0.2 9.9e-29 99.0 0.2 2.0 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.13 CDF90138.1 - 5.2e-21 75.3 7.3 3.8e-20 72.5 0.0 3.7 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.15 CDF90138.1 - 3.6e-20 71.4 1.3 7.5e-20 70.4 0.9 1.6 1 0 0 1 1 1 1 PUA domain GAGA_bind PF06217.7 CDF90138.1 - 0.069 13.1 17.6 0.096 12.6 12.2 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family DDHD PF02862.12 CDF90138.1 - 9.4 5.9 16.5 14 5.3 11.4 1.2 1 0 0 1 1 1 0 DDHD domain UEV PF05743.8 CDF90139.1 - 1.6e-25 89.1 0.0 3.1e-25 88.2 0.0 1.4 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.5 CDF90139.1 - 4.6e-22 77.4 0.5 1.4e-21 75.8 0.2 1.9 2 0 0 2 2 2 1 Vps23 core domain Spc7 PF08317.6 CDF90139.1 - 0.015 13.9 2.0 0.023 13.3 1.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein PLDc_2 PF13091.1 CDF90142.1 - 1.6e-15 56.9 0.0 5.5e-07 29.3 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.17 CDF90142.1 - 8.5e-11 41.2 0.4 5.9e-05 22.7 0.0 2.8 2 0 0 2 2 2 2 Phospholipase D Active site motif PQ-loop PF04193.9 CDF90143.1 - 1.3e-07 31.0 21.5 2.4e-07 30.2 2.5 4.3 4 1 0 4 4 4 3 PQ loop repeat Rer1 PF03248.8 CDF90144.1 - 7.3e-69 230.8 8.4 8.5e-69 230.6 5.8 1.0 1 0 0 1 1 1 1 Rer1 family DUF4564 PF15169.1 CDF90144.1 - 0.11 12.1 0.2 0.17 11.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4564) DUF2208 PF09973.4 CDF90144.1 - 1 8.5 6.8 1.5 7.9 1.9 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) eRF1_2 PF03464.10 CDF90145.1 - 6e-32 110.7 0.5 6e-32 110.7 0.4 1.7 2 0 0 2 2 2 1 eRF1 domain 2 eRF1_3 PF03465.10 CDF90145.1 - 3.4e-23 82.0 0.1 8.3e-23 80.8 0.0 1.7 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.10 CDF90145.1 - 2.5e-12 46.5 0.2 5e-12 45.5 0.1 1.6 1 0 0 1 1 1 1 eRF1 domain 1 RNA12 PF10443.4 CDF90145.1 - 0.00028 19.5 0.3 0.00038 19.0 0.2 1.3 1 0 0 1 1 1 1 RNA12 protein SNF2_N PF00176.18 CDF90145.1 - 0.04 12.7 0.2 0.077 11.7 0.1 1.5 1 0 0 1 1 1 0 SNF2 family N-terminal domain AHS2 PF02626.10 CDF90145.1 - 0.14 11.4 0.1 0.32 10.2 0.0 1.6 2 0 0 2 2 2 0 Allophanate hydrolase subunit 2 Septin PF00735.13 CDF90146.1 - 2.5e-107 358.0 0.4 3e-107 357.8 0.3 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.18 CDF90146.1 - 1e-08 35.1 0.2 2.1e-08 34.1 0.1 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 CDF90146.1 - 5.8e-07 28.8 0.1 1.1e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 CDF90146.1 - 6e-07 29.0 0.3 5.6e-05 22.6 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AIG1 PF04548.11 CDF90146.1 - 3.8e-06 26.1 0.3 8.4e-06 25.0 0.2 1.7 1 1 0 1 1 1 1 AIG1 family Dynamin_N PF00350.18 CDF90146.1 - 2.5e-05 24.1 1.0 0.038 13.7 0.2 2.5 1 1 1 2 2 2 2 Dynamin family FtsK_SpoIIIE PF01580.13 CDF90146.1 - 0.00041 19.8 0.1 0.0015 18.0 0.0 1.8 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_16 PF13191.1 CDF90146.1 - 0.00084 19.3 0.2 0.0016 18.4 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.1 CDF90146.1 - 0.0013 19.0 0.2 0.0018 18.6 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CDF90146.1 - 0.0019 18.0 0.5 0.047 13.5 1.0 2.7 2 1 0 2 2 2 1 AAA domain ABC_tran PF00005.22 CDF90146.1 - 0.0024 18.1 0.5 0.0062 16.8 0.3 1.7 1 1 0 1 1 1 1 ABC transporter AAA_10 PF12846.2 CDF90146.1 - 0.0031 16.9 0.4 0.0046 16.4 0.2 1.4 1 1 0 1 1 1 1 AAA-like domain AAA_22 PF13401.1 CDF90146.1 - 0.004 17.2 0.1 0.012 15.7 0.1 1.9 1 1 0 1 1 1 1 AAA domain Miro PF08477.8 CDF90146.1 - 0.0042 17.5 0.0 0.012 16.1 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein AAA_24 PF13479.1 CDF90146.1 - 0.0065 16.0 0.1 0.013 15.1 0.0 1.5 2 0 0 2 2 1 1 AAA domain PduV-EutP PF10662.4 CDF90146.1 - 0.011 15.2 0.2 1 8.8 0.1 3.0 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NB-ARC PF00931.17 CDF90146.1 - 0.022 13.6 0.0 0.029 13.2 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_14 PF13173.1 CDF90146.1 - 0.022 14.6 0.0 0.075 12.9 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.1 CDF90146.1 - 0.024 14.1 0.0 0.057 12.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Gtr1_RagA PF04670.7 CDF90146.1 - 0.044 12.9 0.8 0.35 9.9 0.5 2.1 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region T2SE PF00437.15 CDF90146.1 - 0.046 12.6 0.1 0.086 11.7 0.1 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein MobB PF03205.9 CDF90146.1 - 0.053 13.2 0.1 0.22 11.2 0.0 2.1 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B FeoB_N PF02421.13 CDF90146.1 - 0.071 12.3 0.1 3.7 6.8 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B IIGP PF05049.8 CDF90146.1 - 0.089 11.5 0.0 0.13 11.0 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_17 PF13207.1 CDF90146.1 - 0.15 12.8 0.3 0.38 11.5 0.2 2.0 1 1 0 1 1 1 0 AAA domain Ribosomal_L32p PF01783.18 CDF90147.1 - 4.4e-09 36.3 9.1 9e-09 35.3 6.3 1.5 1 0 0 1 1 1 1 Ribosomal L32p protein family zf-UBR PF02207.15 CDF90147.1 - 0.0089 15.7 2.6 0.014 15.0 1.8 1.3 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Papo_T_antigen PF02380.10 CDF90147.1 - 0.1 12.5 4.4 0.17 11.8 3.0 1.4 1 0 0 1 1 1 0 T-antigen specific domain zf-FPG_IleRS PF06827.9 CDF90147.1 - 7.7 6.2 8.7 19 5.0 6.0 1.7 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS FMN_red PF03358.10 CDF90148.1 - 8.6e-09 35.0 0.0 1.4e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_1 PF00258.20 CDF90148.1 - 5.7e-07 29.6 0.0 9.6e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin Citrate_synt PF00285.16 CDF90149.1 - 1.6e-102 342.9 0.0 2e-102 342.5 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase Sterol-sensing PF12349.3 CDF90151.1 - 2.9e-06 26.8 6.1 2e-05 24.0 4.2 2.3 1 1 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation CCT_2 PF09425.5 CDF90151.1 - 0.16 11.5 0.3 0.39 10.2 0.2 1.7 1 0 0 1 1 1 0 Divergent CCT motif BAR PF03114.13 CDF90152.1 - 6.3e-53 179.6 2.5 7.9e-53 179.3 1.7 1.1 1 0 0 1 1 1 1 BAR domain DUF1496 PF07383.7 CDF90152.1 - 0.083 12.1 0.3 0.19 10.9 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1496) DUF2303 PF10065.4 CDF90152.1 - 0.097 11.5 0.0 0.15 10.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2303) Seryl_tRNA_N PF02403.17 CDF90152.1 - 1 9.4 7.9 1.2 9.1 0.3 2.6 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain AAA_23 PF13476.1 CDF90152.1 - 3 8.1 8.1 10 6.4 5.6 1.9 1 1 0 1 1 1 0 AAA domain RNA_pol_Rpc34 PF05158.7 CDF90155.1 - 6.2e-96 321.4 3.4 7.6e-96 321.1 2.4 1.0 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit B-block_TFIIIC PF04182.7 CDF90155.1 - 0.0024 17.6 2.5 0.053 13.3 0.1 2.3 1 1 1 2 2 2 2 B-block binding subunit of TFIIIC Rrf2 PF02082.15 CDF90155.1 - 0.019 15.0 1.3 0.066 13.3 0.1 2.1 2 0 0 2 2 2 0 Transcriptional regulator MarR_2 PF12802.2 CDF90155.1 - 0.021 14.4 0.1 1.4 8.6 0.0 2.3 2 0 0 2 2 2 0 MarR family ABC2_membrane PF01061.19 CDF90156.1 - 2.6e-37 128.0 17.0 2.6e-37 128.0 11.8 1.9 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.22 CDF90156.1 - 6.8e-28 97.6 0.0 1.2e-27 96.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 CDF90156.1 - 7e-05 22.9 0.5 7e-05 22.9 0.3 3.1 2 2 0 2 2 2 1 AAA domain AAA_25 PF13481.1 CDF90156.1 - 0.00017 21.0 0.1 0.017 14.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CDF90156.1 - 0.00052 20.0 0.0 0.0011 18.9 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 CDF90156.1 - 0.0011 18.2 0.1 0.0026 16.9 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 CDF90156.1 - 0.0076 15.7 0.3 0.019 14.4 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 CDF90156.1 - 0.02 13.9 0.0 5.3 5.9 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain SbcCD_C PF13558.1 CDF90156.1 - 0.03 14.2 0.0 0.09 12.6 0.0 1.9 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_28 PF13521.1 CDF90156.1 - 0.073 13.0 0.1 0.13 12.1 0.1 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 CDF90156.1 - 0.14 11.7 0.3 0.28 10.8 0.2 1.5 1 0 0 1 1 1 0 NACHT domain T2SE PF00437.15 CDF90156.1 - 0.15 10.9 0.1 0.26 10.1 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Laminin_EGF PF00053.19 CDF90156.1 - 0.39 10.6 33.4 0.15 12.0 4.5 3.9 2 2 1 3 3 3 0 Laminin EGF-like (Domains III and V) PGK PF00162.14 CDF90157.1 - 9.8e-152 504.9 0.1 1.1e-151 504.7 0.1 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DNA_pol_B_palm PF14792.1 CDF90158.1 - 3.1e-14 52.9 0.1 8.9e-14 51.5 0.0 1.9 1 1 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.1 CDF90158.1 - 1.4e-12 47.1 0.0 2.8e-12 46.1 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta thumb HHH_8 PF14716.1 CDF90158.1 - 1.2e-10 41.4 0.1 2.5e-10 40.3 0.1 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.4 CDF90158.1 - 5.5e-07 29.0 0.0 1.2e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda BRCT PF00533.21 CDF90158.1 - 0.0056 16.7 0.1 0.019 15.1 0.0 2.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain HAD PF12710.2 CDF90160.1 - 5.8e-13 49.4 0.0 9.1e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2373 PF10180.4 CDF90161.1 - 1.6e-23 81.9 0.5 4.3e-23 80.6 0.4 1.8 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) Sugar_tr PF00083.19 CDF90162.1 - 1.1e-104 350.5 27.0 1.4e-104 350.2 18.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CDF90162.1 - 5.3e-27 94.4 28.2 5.3e-25 87.8 14.4 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CDF90162.1 - 0.00035 19.1 25.4 0.0018 16.7 4.8 3.4 3 1 0 3 3 3 2 MFS/sugar transport protein DUF4131 PF13567.1 CDF90162.1 - 1.7 8.0 12.0 0.96 8.8 0.2 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4131) DUF2545 PF10810.3 CDF90162.1 - 3.8 7.9 15.1 5 7.5 3.5 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2545) PMT_C PF11647.3 CDF90163.1 - 0.049 13.2 0.1 0.12 11.9 0.0 1.7 2 0 0 2 2 2 0 C-terminal region of Pasteurella multocida toxin residues 569-1285 Frag1 PF10277.4 CDF90164.1 - 2e-34 118.9 13.4 2e-34 118.9 9.3 4.1 4 1 0 4 4 4 2 Frag1/DRAM/Sfk1 family Exo_endo_phos PF03372.18 CDF90164.1 - 0.00076 19.4 0.0 0.0018 18.2 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Alpha-amylase_C PF02806.13 CDF90165.1 - 5e-24 84.2 0.3 3e-23 81.7 0.1 2.4 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.19 CDF90165.1 - 6.8e-17 61.8 1.3 3.6e-16 59.4 0.2 2.6 2 1 0 2 2 2 1 Alpha amylase, catalytic domain CBM_48 PF02922.13 CDF90165.1 - 1.9e-15 56.6 0.0 6.2e-15 55.0 0.0 1.9 2 0 0 2 2 2 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Glyco_hydro_66 PF13199.1 CDF90165.1 - 0.011 14.1 0.0 0.018 13.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 66 UQ_con PF00179.21 CDF90166.1 - 1.7e-39 134.4 0.2 2.2e-39 134.0 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 CDF90166.1 - 0.011 15.6 0.1 0.019 14.8 0.0 1.6 1 1 0 1 1 1 0 RWD domain Nop25 PF09805.4 CDF90166.1 - 0.1 12.7 14.3 0.13 12.2 9.9 1.2 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) TFIIA PF03153.8 CDF90166.1 - 0.21 11.4 15.0 0.22 11.3 10.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Vfa1 PF08432.5 CDF90166.1 - 0.22 11.5 7.6 0.3 11.0 5.3 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CDC45 PF02724.9 CDF90166.1 - 0.3 9.0 12.4 0.36 8.8 8.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Flagellin_C PF00700.16 CDF90167.1 - 0.16 12.1 3.3 0.096 12.8 0.6 1.7 2 0 0 2 2 2 0 Bacterial flagellin C-terminal helical region LSM PF01423.17 CDF90168.1 - 9.5e-12 44.2 0.0 1.3e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 LSM domain TENA_THI-4 PF03070.11 CDF90169.1 - 1.8e-11 44.1 1.7 2.4e-11 43.8 1.2 1.1 1 0 0 1 1 1 1 TENA/THI-4/PQQC family PfkB PF00294.19 CDF90170.1 - 2.5e-11 43.2 0.0 3.1e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase HARP PF07443.8 CDF90170.1 - 0.071 12.4 0.1 1.5 8.2 0.0 2.3 2 0 0 2 2 2 0 HepA-related protein (HARP) Arm PF00514.18 CDF90171.1 - 6.6e-68 222.4 32.0 4.1e-11 42.2 0.0 10.6 11 0 0 11 11 11 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.1 CDF90171.1 - 3.5e-24 84.9 9.6 1.4e-06 28.5 0.1 7.2 3 2 4 7 7 7 6 HEAT repeats HEAT PF02985.17 CDF90171.1 - 5.7e-14 50.8 27.8 0.019 14.9 0.1 11.0 12 0 0 12 12 12 3 HEAT repeat HEAT_EZ PF13513.1 CDF90171.1 - 1.2e-13 51.0 17.0 0.00011 22.5 0.3 7.8 6 1 3 9 9 8 3 HEAT-like repeat Arm_2 PF04826.8 CDF90171.1 - 1.5e-11 43.9 5.2 1.9e-07 30.4 2.4 2.9 1 1 0 2 2 2 2 Armadillo-like Adaptin_N PF01602.15 CDF90171.1 - 4.7e-11 41.7 13.7 3.3e-07 29.0 1.5 3.3 1 1 2 3 3 3 2 Adaptin N terminal region KAP PF05804.7 CDF90171.1 - 6e-11 41.0 0.6 4.4e-10 38.1 0.5 2.1 1 1 0 1 1 1 1 Kinesin-associated protein (KAP) Vac14_Fab1_bd PF12755.2 CDF90171.1 - 6.6e-05 23.2 0.3 0.37 11.2 0.0 4.0 3 2 0 3 3 3 2 Vacuolar 14 Fab1-binding region DUF2454 PF10521.4 CDF90171.1 - 0.00013 21.0 0.0 0.071 12.1 0.0 2.9 3 0 0 3 3 3 2 Protein of unknown function (DUF2454) V-ATPase_H_N PF03224.9 CDF90171.1 - 0.00016 20.8 3.3 0.0048 16.0 0.4 3.3 1 1 2 3 3 3 1 V-ATPase subunit H RIX1 PF08167.7 CDF90171.1 - 0.00046 19.9 1.5 0.012 15.2 0.1 3.3 4 0 0 4 4 4 1 rRNA processing/ribosome biogenesis V-ATPase_H_C PF11698.3 CDF90171.1 - 0.0035 17.2 2.3 1.1 9.2 0.1 4.4 1 1 4 5 5 5 1 V-ATPase subunit H DUF1981 PF09324.5 CDF90171.1 - 0.13 11.7 0.3 35 3.9 0.0 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF1981) YjeF_N PF03853.10 CDF90172.1 - 1.4e-28 99.6 0.0 2.6e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.5 CDF90172.1 - 4.7e-07 30.2 10.8 5.4e-06 26.8 7.4 2.3 1 1 0 1 1 1 1 FDF domain Phage_hub_GP28 PF11110.3 CDF90172.1 - 0.1 12.2 0.2 0.62 9.7 0.0 2.2 2 0 0 2 2 2 0 Baseplate hub distal subunit adh_short_C2 PF13561.1 CDF90174.1 - 1.9e-22 80.2 0.1 3.4e-21 76.1 0.1 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CDF90174.1 - 2.5e-19 69.8 1.7 1.5e-17 64.0 1.2 2.3 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CDF90174.1 - 6.6e-12 45.4 0.8 1.6e-11 44.2 0.3 1.7 1 1 1 2 2 2 1 KR domain Epimerase PF01370.16 CDF90174.1 - 6.6e-05 22.4 0.2 0.00011 21.6 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CDF90174.1 - 0.014 14.1 0.0 0.019 13.6 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 CDF90174.1 - 0.04 12.8 1.5 0.17 10.7 0.6 2.3 2 1 0 2 2 2 0 RmlD substrate binding domain 3HCDH_N PF02737.13 CDF90174.1 - 0.061 12.9 0.1 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glyco_transf_5 PF08323.6 CDF90174.1 - 0.075 12.5 0.1 4.8 6.5 0.0 2.1 2 0 0 2 2 2 0 Starch synthase catalytic domain Phosphodiest PF01663.17 CDF90175.1 - 1.6e-66 225.0 0.1 2.1e-66 224.7 0.1 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 CDF90175.1 - 0.0011 18.2 0.0 0.002 17.3 0.0 1.5 1 0 0 1 1 1 1 Sulfatase DUF229 PF02995.12 CDF90175.1 - 0.11 10.8 0.0 0.14 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) MFS_1 PF07690.11 CDF90176.1 - 3.6e-36 124.6 11.9 3.6e-36 124.6 8.3 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CDF90176.1 - 3.9e-07 29.0 8.2 1e-06 27.6 0.0 2.8 3 0 0 3 3 3 2 Sugar (and other) transporter UPF0104 PF03706.8 CDF90176.1 - 0.035 13.4 0.6 0.035 13.4 0.4 3.6 3 1 1 4 4 4 0 Uncharacterised protein family (UPF0104) DUF4231 PF14015.1 CDF90176.1 - 0.15 12.0 1.0 0.58 10.1 0.7 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) RskA PF10099.4 CDF90176.1 - 0.19 11.4 0.0 1.3 8.7 0.1 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF2207 PF09972.4 CDF90176.1 - 2.8 6.4 6.3 1.3 7.4 2.1 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DUF4233 PF14017.1 CDF90176.1 - 2.9 7.8 14.3 0.041 13.7 2.6 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF4233) ArfGap PF01412.13 CDF90178.1 - 4.2e-33 113.6 0.7 1.2e-32 112.0 0.5 1.8 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Pol_alpha_B_N PF08418.5 CDF90178.1 - 9.2 5.7 18.7 6.8 6.1 11.0 2.1 2 1 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal 2-Hacid_dh_C PF02826.14 CDF90179.1 - 1.8e-40 137.9 0.0 5.7e-40 136.3 0.0 1.8 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 CDF90179.1 - 6.1e-18 64.5 0.1 9.3e-18 63.9 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain RNase_PH_C PF03725.10 CDF90179.1 - 0.065 13.1 0.2 0.56 10.1 0.0 2.4 2 0 0 2 2 2 0 3' exoribonuclease family, domain 2 DUF3782 PF12644.2 CDF90179.1 - 0.12 12.1 0.0 2.3 8.0 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3782) Pkinase PF00069.20 CDF90181.1 - 1.4e-27 96.4 0.0 1.9e-27 96.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF90181.1 - 3.2e-08 32.9 0.0 4.5e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Peptidase_M44 PF03410.8 CDF90181.1 - 0.052 11.7 0.0 0.074 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein G1 MRG PF05712.8 CDF90182.1 - 2.6e-44 150.4 0.0 5.3e-44 149.4 0.0 1.5 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.3 CDF90182.1 - 2.1e-06 27.3 0.2 6.1e-06 25.8 0.1 1.9 1 1 0 1 1 1 1 RNA binding activity-knot of a chromodomain DUF349 PF03993.7 CDF90182.1 - 0.036 14.2 3.5 0.083 13.0 2.4 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) Mito_carr PF00153.22 CDF90183.1 - 2.9e-73 241.6 0.7 7.5e-25 86.4 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_8 PF13833.1 CDF90183.1 - 0.11 12.1 2.2 7.4 6.2 0.1 4.1 4 0 0 4 4 4 0 EF-hand domain pair EF-hand_7 PF13499.1 CDF90183.1 - 0.12 12.5 9.8 0.1 12.7 0.5 4.8 6 1 0 6 6 6 0 EF-hand domain pair Bud13 PF09736.4 CDF90185.1 - 2.1e-27 96.1 3.7 2.1e-27 96.1 2.5 3.7 2 2 1 3 3 3 1 Pre-mRNA-splicing factor of RES complex XRN_N PF03159.13 CDF90186.1 - 4.5e-100 333.9 0.4 1.5e-99 332.1 0.1 2.1 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus Nucleoporin_FG PF13634.1 CDF90187.1 - 3.7e-26 91.5 159.3 6.2e-09 36.0 35.7 4.6 1 1 3 4 4 4 4 Nucleoporin FG repeat region DUF1664 PF07889.7 CDF90187.1 - 0.06 13.1 2.1 0.28 10.9 0.1 2.6 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) DEAD PF00270.24 CDF90188.1 - 1.2e-42 145.2 0.7 2.4e-42 144.3 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF90188.1 - 4.3e-27 93.7 0.1 1.7e-26 91.8 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDF90188.1 - 0.00017 21.5 1.6 0.00021 21.1 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 CDF90188.1 - 0.023 14.8 0.2 0.1 12.7 0.2 2.1 1 1 0 1 1 1 0 AAA domain Helicase_C_2 PF13307.1 CDF90188.1 - 0.072 13.0 0.0 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 Helicase C-terminal domain ATP-synt_G PF04718.10 CDF90189.1 - 2.9e-27 95.3 0.0 3.3e-27 95.1 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase g subunit MCM PF00493.18 CDF90190.1 - 8.6e-139 461.9 0.1 1.2e-138 461.4 0.0 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 CDF90190.1 - 4.2e-24 85.3 3.3 7.3e-24 84.5 1.0 2.5 3 0 0 3 3 3 1 MCM N-terminal domain Mg_chelatase PF01078.16 CDF90190.1 - 3.8e-06 26.2 0.0 0.00028 20.1 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 CDF90190.1 - 1.5e-05 24.7 0.0 4.9e-05 23.0 0.0 2.0 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 CDF90190.1 - 0.00059 19.4 0.0 0.011 15.3 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 CDF90190.1 - 0.11 11.9 0.1 3.9 6.9 0.0 3.0 3 0 0 3 3 3 0 Sigma-54 interaction domain CAF1A PF12253.3 CDF90191.1 - 1.2e-21 76.5 10.8 1.2e-21 76.5 7.5 3.7 3 1 0 3 3 3 1 Chromatin assembly factor 1 subunit A CAF-1_p150 PF11600.3 CDF90191.1 - 9.1e-17 61.1 64.0 9.1e-17 61.1 44.4 2.5 2 0 0 2 2 2 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal DDRGK PF09756.4 CDF90191.1 - 9.3 5.6 54.0 0.15 11.4 32.1 2.0 2 0 0 2 2 2 0 DDRGK domain CCDC-167 PF15188.1 CDF90192.1 - 0.013 15.4 3.4 0.013 15.4 2.3 2.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 DUF4639 PF15479.1 CDF90192.1 - 2.4 6.7 7.7 0.31 9.6 1.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4639) eIF-6 PF01912.13 CDF90193.1 - 2.4e-84 281.3 0.5 3e-84 281.0 0.3 1.1 1 0 0 1 1 1 1 eIF-6 family zf-C2H2 PF00096.21 CDF90194.1 - 3.1e-08 33.4 13.4 0.00022 21.3 1.0 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CDF90194.1 - 3.1e-05 24.0 12.9 0.00017 21.6 1.3 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.1 CDF90194.1 - 3.4e-05 23.8 9.9 0.0041 17.3 0.7 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.2 CDF90194.1 - 0.00019 21.5 6.9 0.006 16.7 0.3 2.3 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 CDF90194.1 - 0.0068 16.5 4.7 0.14 12.3 0.0 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-BED PF02892.10 CDF90194.1 - 0.26 11.0 9.3 2.8 7.7 3.0 2.2 1 1 1 2 2 2 0 BED zinc finger zf-H2C2_5 PF13909.1 CDF90194.1 - 5.4 7.4 13.9 2.4 8.5 1.4 2.9 2 2 0 2 2 2 0 C2H2-type zinc-finger domain Mito_carr PF00153.22 CDF90195.1 - 2.3e-74 245.1 3.5 1.7e-26 91.7 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein UcrQ PF02939.11 CDF90195.1 - 0.011 15.5 0.3 0.79 9.5 0.0 3.0 4 0 0 4 4 4 0 UcrQ family B12D PF06522.6 CDF90196.1 - 0.01 15.5 0.0 0.014 15.0 0.0 1.3 1 1 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit Xan_ur_permease PF00860.15 CDF90197.1 - 1.6e-60 204.7 25.3 2.4e-60 204.0 17.5 1.2 1 0 0 1 1 1 1 Permease family RNA_pol_Rpb2_6 PF00562.23 CDF90198.1 - 4.9e-115 384.3 0.0 6.7e-115 383.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 CDF90198.1 - 2.7e-47 160.3 0.0 3.8e-47 159.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.9 CDF90198.1 - 4.6e-33 114.2 0.0 1e-32 113.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.11 CDF90198.1 - 6.3e-25 86.7 0.0 5.6e-24 83.6 0.0 2.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.7 CDF90198.1 - 2.7e-21 75.2 0.0 6.5e-21 74.0 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.15 CDF90198.1 - 2.6e-15 56.4 0.0 1.7e-14 53.8 0.0 2.3 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_5 PF04567.12 CDF90198.1 - 1.2e-05 25.1 0.0 3.1e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 E1-E2_ATPase PF00122.15 CDF90199.1 - 2.5e-76 255.7 1.2 9e-76 253.9 0.1 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.16 CDF90199.1 - 9.6e-49 165.3 1.7 9.6e-49 165.3 1.2 2.5 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.21 CDF90199.1 - 7e-33 114.8 0.0 1.7e-32 113.5 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 CDF90199.1 - 5e-18 65.9 0.0 1.2e-17 64.7 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CDF90199.1 - 5.7e-18 64.6 0.1 1.1e-17 63.6 0.1 1.5 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Cation_ATPase_N PF00690.21 CDF90199.1 - 4.6e-17 61.2 0.0 9.9e-17 60.1 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.7 CDF90199.1 - 2.4e-05 24.0 2.3 0.0018 17.9 0.8 2.5 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Sua5_yciO_yrdC PF01300.13 CDF90200.1 - 1.4e-49 167.7 0.0 2.1e-49 167.1 0.0 1.2 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.8 CDF90200.1 - 6.1e-31 107.0 0.0 1e-30 106.3 0.0 1.4 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding MobB PF03205.9 CDF90200.1 - 0.11 12.2 0.1 2.3 7.8 0.0 2.2 1 1 1 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B CDC27 PF09507.5 CDF90202.1 - 1e-05 24.9 30.7 0.0045 16.2 20.3 2.4 2 1 0 2 2 2 2 DNA polymerase subunit Cdc27 ATP-synt_C PF00137.16 CDF90203.1 - 2.9e-31 107.1 29.2 7.9e-18 64.1 6.8 2.1 2 0 0 2 2 2 2 ATP synthase subunit C DUF2970 PF11174.3 CDF90203.1 - 0.82 9.2 8.4 0.57 9.7 1.6 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) Nucleopor_Nup85 PF07575.8 CDF90204.1 - 3.2e-166 553.8 4.5 3.7e-166 553.6 3.1 1.0 1 0 0 1 1 1 1 Nup85 Nucleoporin Urb2 PF10441.4 CDF90205.1 - 3.5e-51 173.9 2.2 1.1e-50 172.3 1.5 1.9 1 0 0 1 1 1 1 Urb2/Npa2 family Voltage_CLC PF00654.15 CDF90206.1 - 4.3e-79 266.1 21.5 4.3e-79 266.1 14.9 1.4 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.23 CDF90206.1 - 2.7e-10 39.8 0.1 3.7e-05 23.4 0.0 2.6 2 0 0 2 2 2 2 CBS domain Ribosomal_L7Ae PF01248.21 CDF90207.1 - 1e-26 92.2 0.0 1.2e-26 92.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 CDF90207.1 - 0.0031 17.3 0.1 0.0032 17.3 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 PELOTA_1 PF15608.1 CDF90207.1 - 0.029 14.1 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 PELOTA RNA binding domain HECT PF00632.20 CDF90210.1 - 2.4e-82 276.6 1.5 2.4e-82 276.6 1.0 2.2 4 0 0 4 4 4 1 HECT-domain (ubiquitin-transferase) Cys_rich_CPCC PF14206.1 CDF90210.1 - 0.11 12.0 5.2 0.32 10.5 1.1 2.6 2 0 0 2 2 2 0 Cysteine-rich CPCC OrfB_Zn_ribbon PF07282.6 CDF90210.1 - 0.73 9.5 6.2 2.2 7.9 4.3 1.8 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Rieske PF00355.21 CDF90211.1 - 1.1e-18 66.6 0.0 1.7e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.9 CDF90211.1 - 6.8e-18 64.6 1.4 1.3e-17 63.8 1.0 1.5 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region DUF2235 PF09994.4 CDF90212.1 - 8e-80 268.1 0.0 1.7e-79 267.0 0.0 1.6 2 0 0 2 2 2 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) SNF2_N PF00176.18 CDF90213.1 - 1.9e-75 253.4 0.0 3e-75 252.8 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CDF90213.1 - 5.7e-15 54.9 0.0 1.9e-14 53.2 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF2684 PF10885.3 CDF90213.1 - 0.053 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2684) Peptidase_M14 PF00246.19 CDF90213.1 - 0.071 12.7 2.2 0.084 12.4 0.7 1.7 2 0 0 2 2 2 0 Zinc carboxypeptidase Pet191_N PF10203.4 CDF90214.1 - 9.2e-25 86.4 3.4 9.2e-25 86.4 2.4 1.5 2 0 0 2 2 2 1 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.5 CDF90214.1 - 0.05 13.3 0.4 2.8 7.8 0.0 2.4 2 0 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Rav1p_C PF12234.3 CDF90215.1 - 6.9e-256 850.4 3.5 6.9e-256 850.4 2.4 1.4 2 0 0 2 2 2 1 RAVE protein 1 C terminal WD40 PF00400.27 CDF90215.1 - 0.14 12.1 1.9 9.7 6.2 0.1 3.8 3 0 0 3 3 3 0 WD domain, G-beta repeat MSP1a PF11670.3 CDF90215.1 - 1.1 9.1 3.5 1.8 8.4 2.4 1.3 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) Pro_isomerase PF00160.16 CDF90216.1 - 5.2e-39 133.9 0.9 8.6e-39 133.2 0.2 1.7 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_11 PF13414.1 CDF90216.1 - 3.8e-12 45.6 8.5 2.6e-08 33.3 0.8 3.0 3 0 0 3 3 3 2 TPR repeat TPR_2 PF07719.12 CDF90216.1 - 1.2e-08 34.2 11.6 0.0063 16.3 0.2 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.23 CDF90216.1 - 6.9e-06 25.4 10.5 0.00037 19.9 0.2 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.1 CDF90216.1 - 0.0012 18.7 5.1 0.036 14.0 1.6 3.1 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 CDF90216.1 - 0.0023 18.5 0.8 0.0066 17.0 0.3 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 CDF90216.1 - 0.12 12.2 3.0 0.45 10.4 0.7 2.7 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.1 CDF90216.1 - 0.16 11.7 10.9 1.7 8.6 0.9 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.1 CDF90216.1 - 0.68 10.5 4.6 20 5.9 0.0 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Sec7 PF01369.15 CDF90217.1 - 8.9e-63 211.4 3.2 8.9e-63 211.4 2.2 2.8 3 0 0 3 3 3 1 Sec7 domain Sec7_N PF12783.2 CDF90217.1 - 6.3e-15 55.0 3.9 7.9e-15 54.6 0.4 2.8 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Mito_carr PF00153.22 CDF90218.1 - 6.4e-14 51.4 0.3 5.3e-10 38.8 0.0 3.2 4 0 0 4 4 4 2 Mitochondrial carrier protein OMPdecase PF00215.19 CDF90219.1 - 5.2e-77 258.2 0.0 6e-77 258.0 0.0 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family zf-Tim10_DDP PF02953.10 CDF90220.1 - 4.1e-21 74.0 3.5 5.3e-21 73.6 2.4 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Vicilin_N PF04702.7 CDF90220.1 - 0.27 10.8 2.2 0.34 10.5 1.5 1.2 1 0 0 1 1 1 0 Vicilin N terminal region MFS_1 PF07690.11 CDF90221.1 - 3.7e-22 78.5 23.5 3.7e-22 78.5 16.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CDF90221.1 - 5.5e-09 35.1 4.2 5.5e-09 35.1 2.9 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1_like PF12832.2 CDF90221.1 - 0.0091 15.7 0.8 1 9.2 0.2 3.2 2 1 0 2 2 2 1 MFS_1 like family TRI12 PF06609.8 CDF90221.1 - 0.14 10.2 5.5 0.011 13.9 0.5 1.5 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) TPP_enzyme_N PF02776.13 CDF90222.1 - 4.6e-43 146.6 0.1 7.4e-42 142.7 0.0 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.17 CDF90222.1 - 1.6e-26 92.6 0.0 2.8e-26 91.8 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.16 CDF90222.1 - 3.7e-20 72.0 0.0 1.4e-19 70.1 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain tRNA-synt_2 PF00152.15 CDF90223.1 - 2.1e-73 247.0 0.0 2.7e-73 246.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 CDF90223.1 - 4e-08 32.9 0.0 8.1e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 CDF90223.1 - 0.028 13.6 0.0 2.5 7.2 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) zf-Nse PF11789.3 CDF90224.1 - 3.3e-19 68.1 0.3 6.1e-19 67.2 0.2 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.1 CDF90224.1 - 2.4e-05 23.9 0.8 9.2e-05 22.0 0.6 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.1 CDF90224.1 - 0.00031 20.4 0.7 0.00082 19.1 0.3 1.9 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.20 CDF90224.1 - 0.0092 15.6 0.5 0.024 14.2 0.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.7 CDF90224.1 - 0.025 13.7 0.1 0.041 13.0 0.0 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger zf-C3HC4_2 PF13923.1 CDF90224.1 - 0.036 14.1 1.7 0.098 12.7 1.2 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 CDF90224.1 - 0.052 13.3 0.4 0.094 12.5 0.3 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-MIZ PF02891.15 CDF90224.1 - 0.096 12.2 0.4 0.096 12.2 0.3 2.4 3 0 0 3 3 3 0 MIZ/SP-RING zinc finger U-box PF04564.10 CDF90224.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 U-box domain 4HBT PF03061.17 CDF90226.1 - 1.3e-07 31.6 0.0 3.5e-07 30.2 0.0 1.7 2 0 0 2 2 2 1 Thioesterase superfamily Sugar_tr PF00083.19 CDF90227.1 - 1.8e-77 260.8 28.2 2.3e-77 260.5 19.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CDF90227.1 - 2.8e-10 39.4 37.1 2.8e-10 39.4 25.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1700 PF08006.6 CDF90227.1 - 0.5 9.6 3.8 1.2 8.3 2.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) Cnd2 PF05786.9 CDF90228.1 - 5.2e-126 421.9 18.3 1.3e-125 420.6 12.7 1.6 1 1 0 1 1 1 1 Condensin complex subunit 2 Rad21_Rec8_N PF04825.8 CDF90228.1 - 0.023 14.6 0.0 0.052 13.5 0.0 1.5 1 0 0 1 1 1 0 N terminus of Rad21 / Rec8 like protein FAD_binding_3 PF01494.14 CDF90229.1 - 9.6e-23 80.7 0.0 3.4e-22 78.9 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.19 CDF90229.1 - 1.7e-07 30.5 0.0 3.1e-05 23.0 0.0 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.22 CDF90229.1 - 2.9e-07 30.7 0.1 0.00055 20.2 0.0 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CDF90229.1 - 3.7e-05 23.6 0.0 0.00013 21.9 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SE PF08491.5 CDF90229.1 - 0.00087 18.1 0.0 0.016 14.0 0.0 2.1 2 0 0 2 2 2 1 Squalene epoxidase Pyr_redox_2 PF07992.9 CDF90229.1 - 0.0012 18.7 0.3 0.0047 16.8 0.2 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 CDF90229.1 - 0.0013 17.7 0.0 0.0019 17.1 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_2 PF00890.19 CDF90229.1 - 0.0025 16.7 0.1 0.004 16.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 CDF90229.1 - 0.0029 16.1 0.0 0.089 11.2 0.0 2.3 2 0 0 2 2 2 1 HI0933-like protein 3HCDH_N PF02737.13 CDF90229.1 - 0.0044 16.6 0.0 0.0087 15.7 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 CDF90229.1 - 0.011 15.1 0.1 0.03 13.7 0.0 1.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_oxidored PF12831.2 CDF90229.1 - 0.055 12.5 0.4 0.45 9.5 0.2 2.0 1 1 0 1 1 1 0 FAD dependent oxidoreductase Trp_halogenase PF04820.9 CDF90229.1 - 0.068 11.7 0.8 17 3.9 0.0 3.0 3 0 0 3 3 3 0 Tryptophan halogenase ApbA PF02558.11 CDF90229.1 - 0.092 12.1 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Pyr_redox_3 PF13738.1 CDF90229.1 - 0.094 12.7 0.0 0.4 10.7 0.0 1.9 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CDF90229.1 - 0.15 11.1 0.0 0.31 10.0 0.0 1.5 1 0 0 1 1 1 0 Thi4 family Peptidase_M41 PF01434.13 CDF90230.1 - 3.2e-68 229.3 0.1 5.2e-68 228.6 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.24 CDF90230.1 - 1.8e-40 138.1 0.0 3.9e-40 137.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CDF90230.1 - 6.2e-06 26.3 0.2 9.4e-05 22.4 0.0 2.6 3 1 0 3 3 2 1 AAA ATPase domain AAA_22 PF13401.1 CDF90230.1 - 6.7e-05 23.0 0.1 0.082 13.0 0.1 2.9 2 1 1 3 3 2 1 AAA domain TIP49 PF06068.8 CDF90230.1 - 0.00032 19.5 0.0 0.00055 18.7 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_17 PF13207.1 CDF90230.1 - 0.00069 20.4 0.0 0.0025 18.6 0.0 2.0 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.7 CDF90230.1 - 0.00087 18.4 0.0 0.0033 16.4 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 CDF90230.1 - 0.0023 17.6 2.3 0.0076 15.9 1.6 1.9 1 0 0 1 1 1 1 Part of AAA domain AAA_5 PF07728.9 CDF90230.1 - 0.0026 17.4 0.1 0.0092 15.7 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 CDF90230.1 - 0.0032 16.8 0.1 0.011 15.1 0.0 1.8 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_25 PF13481.1 CDF90230.1 - 0.0046 16.3 1.4 0.069 12.5 0.5 2.3 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.1 CDF90230.1 - 0.015 15.6 0.2 0.063 13.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain PhoH PF02562.11 CDF90230.1 - 0.019 14.1 0.8 0.3 10.2 0.2 2.3 2 0 0 2 2 2 0 PhoH-like protein AAA_14 PF13173.1 CDF90230.1 - 0.022 14.6 0.0 0.087 12.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.7 CDF90230.1 - 0.028 13.4 0.0 0.06 12.4 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Mg_chelatase PF01078.16 CDF90230.1 - 0.039 13.1 0.0 0.077 12.1 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.1 CDF90230.1 - 0.042 13.7 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF2629 PF10945.3 CDF90230.1 - 0.088 12.1 0.0 0.38 10.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2629) AAA_2 PF07724.9 CDF90230.1 - 0.094 12.6 0.0 0.38 10.6 0.0 2.1 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_28 PF13521.1 CDF90230.1 - 0.12 12.3 0.2 0.3 11.0 0.0 1.9 2 0 0 2 2 1 0 AAA domain Peptidase_M50B PF13398.1 CDF90230.1 - 0.13 11.6 0.2 0.27 10.6 0.1 1.4 1 0 0 1 1 1 0 Peptidase M50B-like KaiC PF06745.8 CDF90230.1 - 0.15 11.1 0.0 0.39 9.7 0.0 1.7 2 0 0 2 2 2 0 KaiC Cyclin_N PF00134.18 CDF90231.1 - 5.8e-11 42.0 0.8 1e-10 41.2 0.6 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain TFIIB PF00382.14 CDF90231.1 - 0.098 12.4 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Transcription factor TFIIB repeat ATP-synt_ab PF00006.20 CDF90232.1 - 7.7e-69 231.4 0.0 1.2e-68 230.8 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 CDF90232.1 - 1.5e-25 89.8 0.7 3.9e-25 88.5 0.1 1.9 2 0 0 2 2 2 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 CDF90232.1 - 2.6e-17 62.7 1.0 6.2e-17 61.5 0.7 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.5 CDF90232.1 - 0.0023 17.7 1.6 0.0062 16.4 0.4 2.3 2 1 0 2 2 2 1 HAS barrel domain HTH_IclR PF09339.5 CDF90232.1 - 0.025 14.1 0.3 0.18 11.3 0.1 2.5 2 0 0 2 2 2 0 IclR helix-turn-helix domain AAA_25 PF13481.1 CDF90232.1 - 0.091 12.1 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Glyco_hydro_65m PF03632.10 CDF90233.1 - 1.2e-95 320.3 1.1 6.6e-95 317.9 0.8 2.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65N PF03636.10 CDF90233.1 - 1.1e-41 142.8 0.1 1.7e-41 142.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65C PF03633.10 CDF90233.1 - 6.7e-12 45.3 0.5 2.2e-11 43.6 0.0 2.1 2 0 0 2 2 2 1 Glycosyl hydrolase family 65, C-terminal domain TB2_DP1_HVA22 PF03134.14 CDF90234.1 - 1e-30 105.2 5.0 1.5e-30 104.7 3.5 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Peptidase_M50B PF13398.1 CDF90234.1 - 0.64 9.3 8.3 0.31 10.4 4.1 1.6 1 1 0 1 1 1 0 Peptidase M50B-like Adaptin_N PF01602.15 CDF90235.1 - 1.3e-106 357.0 11.6 1.8e-106 356.5 8.0 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.15 CDF90235.1 - 3.7e-07 30.4 0.2 9.8e-07 29.0 0.1 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain Arrestin_C PF02752.17 CDF90236.1 - 2.2e-16 60.2 0.0 8e-15 55.1 0.0 3.0 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 CDF90236.1 - 0.019 14.7 3.1 0.38 10.5 0.0 3.2 2 1 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain Got1 PF04178.7 CDF90237.1 - 2.2e-31 108.4 17.1 3e-31 107.9 11.9 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family DUF1049 PF06305.6 CDF90237.1 - 3.3 7.2 5.3 22 4.6 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) Mannosyl_trans3 PF11051.3 CDF90238.1 - 1.9e-72 243.8 0.0 3.6e-72 242.9 0.0 1.5 1 0 0 1 1 1 1 Mannosyltransferase putative DUF3679 PF12438.3 CDF90238.1 - 0.019 14.3 0.1 0.042 13.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3679) zf-HC5HC2H_2 PF13832.1 CDF90239.1 - 3e-31 107.6 8.8 3e-31 107.6 6.1 2.9 3 0 0 3 3 3 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.1 CDF90239.1 - 1.3e-27 95.7 6.4 1.3e-27 95.7 4.4 3.7 2 1 1 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.1 CDF90239.1 - 6.9e-14 50.8 3.0 6.9e-14 50.8 2.1 2.6 2 0 0 2 2 2 1 PHD-finger PHD PF00628.24 CDF90239.1 - 6e-11 41.8 19.3 7.8e-10 38.2 3.0 2.9 2 0 0 2 2 2 2 PHD-finger EPL1 PF10513.4 CDF90239.1 - 2.5e-08 34.3 0.2 6.1e-08 33.0 0.1 1.7 1 0 0 1 1 1 1 Enhancer of polycomb-like zf-RING-like PF08746.6 CDF90239.1 - 0.0026 17.7 16.1 0.18 11.8 4.9 2.9 2 0 0 2 2 2 2 RING-like domain C1_1 PF00130.17 CDF90239.1 - 0.0047 16.6 0.3 0.0047 16.6 0.2 2.8 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.1 CDF90239.1 - 0.016 14.9 14.9 0.35 10.6 2.6 2.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-PHD-like PF15446.1 CDF90239.1 - 9.3 5.5 16.1 0.038 13.2 3.0 2.7 2 1 0 2 2 2 0 PHD/FYVE-zinc-finger like domain zf-RING_2 PF13639.1 CDF90240.1 - 0.36 10.6 10.4 0.2 11.5 1.4 3.8 4 0 0 4 4 4 0 Ring finger domain Pkinase PF00069.20 CDF90241.1 - 3.3e-63 213.2 0.1 1.6e-62 211.0 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF90241.1 - 3.3e-34 118.1 0.0 1.1e-33 116.3 0.0 1.9 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.11 CDF90241.1 - 4.4e-28 96.8 16.1 1.9e-15 56.3 3.8 3.1 2 0 0 2 2 2 2 Hr1 repeat C1_1 PF00130.17 CDF90241.1 - 1.5e-18 66.2 35.2 1.2e-10 40.9 10.2 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.19 CDF90241.1 - 1.2e-10 41.7 3.6 5.7e-10 39.5 2.5 2.3 1 0 0 1 1 1 1 Protein kinase C terminal domain DUF4206 PF13901.1 CDF90241.1 - 6.1 6.3 33.2 0.35 10.3 4.4 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4206) Lgl_C PF08596.5 CDF90242.1 - 3.1e-126 421.0 0.1 1e-125 419.2 0.0 1.8 2 0 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal Cid2 PF09774.4 CDF90243.1 - 2.2e-32 112.2 0.1 2.7e-32 111.9 0.1 1.1 1 0 0 1 1 1 1 Caffeine-induced death protein 2 IDO PF01231.13 CDF90244.1 - 4.3e-161 536.0 0.0 5.1e-161 535.8 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase tRNA-synt_His PF13393.1 CDF90245.1 - 1e-39 136.4 0.0 1.5e-34 119.4 0.0 2.1 2 0 0 2 2 2 2 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.20 CDF90245.1 - 1.1e-19 70.7 0.0 1e-18 67.5 0.0 2.1 2 1 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 CDF90245.1 - 7.8e-14 51.3 0.0 1.4e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2 PF00152.15 CDF90245.1 - 0.0026 16.5 0.0 0.032 12.9 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.15 CDF90245.1 - 0.026 13.7 0.0 0.048 12.8 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) HGTP_anticodon2 PF12745.2 CDF90245.1 - 0.075 12.1 0.1 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs AIM24 PF01987.12 CDF90246.1 - 1.6e-07 30.9 0.0 5.1e-07 29.3 0.0 1.8 1 1 0 1 1 1 1 Mitochondrial biogenesis AIM24 NuA4 PF09340.5 CDF90247.1 - 4.9e-22 77.3 7.0 2.6e-21 75.0 4.8 1.9 1 1 0 1 1 1 1 Histone acetyltransferase subunit NuA4 DUF972 PF06156.8 CDF90247.1 - 0.013 15.7 0.1 0.015 15.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF972) IncA PF04156.9 CDF90247.1 - 0.053 13.1 1.4 0.075 12.6 1.0 1.2 1 0 0 1 1 1 0 IncA protein DWNN PF08783.6 CDF90247.1 - 0.089 12.7 0.3 0.91 9.5 0.1 2.1 2 0 0 2 2 2 0 DWNN domain GAS PF13851.1 CDF90247.1 - 0.1 11.7 3.9 0.13 11.4 2.7 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Actin PF00022.14 CDF90248.1 - 1.6e-48 165.0 0.8 4e-38 130.8 0.0 2.1 2 0 0 2 2 2 2 Actin MreB_Mbl PF06723.8 CDF90248.1 - 0.00077 18.1 0.0 0.15 10.6 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein Gln-synt_C PF00120.19 CDF90249.1 - 1.3e-62 211.2 0.0 1.6e-62 210.9 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.14 CDF90249.1 - 2.7e-19 68.5 0.0 4.4e-19 67.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain V-ATPase_H_N PF03224.9 CDF90250.1 - 4.7e-56 190.1 10.8 4.7e-56 190.1 7.5 1.5 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.3 CDF90250.1 - 3.6e-38 130.1 0.4 3.6e-38 130.1 0.3 2.5 3 0 0 3 3 3 1 V-ATPase subunit H YlqD PF11068.3 CDF90251.1 - 0.092 12.7 0.6 0.092 12.7 0.4 1.9 2 0 0 2 2 2 0 YlqD protein PCI PF01399.22 CDF90252.1 - 1.6e-05 25.1 0.0 4.1e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 PCI domain Tmemb_14 PF03647.8 CDF90254.1 - 1.3e-25 89.5 7.4 1.5e-25 89.3 5.1 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C G-gamma PF00631.17 CDF90255.1 - 8.5e-20 70.2 0.0 1.1e-19 69.9 0.0 1.2 1 0 0 1 1 1 1 GGL domain Evr1_Alr PF04777.8 CDF90256.1 - 9.6e-27 92.7 0.3 1.5e-26 92.0 0.2 1.3 1 0 0 1 1 1 1 Erv1 / Alr family Toxin-deaminase PF14424.1 CDF90256.1 - 0.14 12.1 0.0 0.55 10.2 0.0 1.8 1 1 0 1 1 1 0 The BURPS668_1122 family of deaminases TIP41 PF04176.8 CDF90257.1 - 4.1e-71 237.9 2.9 5.5e-71 237.5 2.0 1.1 1 0 0 1 1 1 1 TIP41-like family TPR_11 PF13414.1 CDF90258.1 - 6.5e-05 22.4 0.2 0.00037 20.0 0.1 2.2 2 1 1 3 3 3 1 TPR repeat TPR_2 PF07719.12 CDF90258.1 - 0.00048 19.8 1.9 0.0015 18.2 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.23 CDF90258.1 - 0.00093 18.7 0.1 0.0074 15.8 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.1 CDF90258.1 - 0.0012 18.6 0.4 0.0056 16.5 0.0 2.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.1 CDF90258.1 - 0.0019 18.2 0.0 0.72 10.2 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 CDF90258.1 - 0.0027 18.3 0.2 0.11 13.2 0.1 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.1 CDF90258.1 - 0.011 15.4 0.0 0.055 13.2 0.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.1 CDF90258.1 - 0.02 14.6 0.1 0.18 11.6 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.1 CDF90258.1 - 0.026 15.1 0.1 0.43 11.3 0.0 3.0 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.1 CDF90258.1 - 0.1 12.5 2.1 1.1 9.2 0.0 3.0 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.1 CDF90258.1 - 0.22 12.0 4.4 16 6.1 0.0 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat eIF-5_eIF-2B PF01873.12 CDF90259.1 - 9.9e-43 144.7 0.0 1.9e-42 143.8 0.0 1.5 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.13 CDF90259.1 - 2.7e-27 94.5 4.9 2.6e-26 91.3 0.0 3.3 3 0 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon DUF4088 PF13317.1 CDF90259.1 - 0.022 14.1 0.7 0.04 13.2 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4088) Zn-ribbon_8 PF09723.5 CDF90259.1 - 0.17 11.8 1.4 0.49 10.3 1.0 1.8 1 0 0 1 1 1 0 Zinc ribbon domain F-box-like PF12937.2 CDF90261.1 - 6.5e-08 32.1 0.6 1.6e-07 30.9 0.4 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CDF90261.1 - 1.3e-05 24.6 0.4 4e-05 23.1 0.3 1.9 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.2 CDF90261.1 - 4.1e-05 23.0 9.2 0.53 9.9 1.8 6.4 4 3 2 6 6 6 2 Leucine Rich repeats (2 copies) DUF1699 PF08004.6 CDF90261.1 - 0.0051 16.3 0.7 0.54 9.7 0.0 3.8 4 0 0 4 4 4 1 Protein of unknown function (DUF1699) AsnA PF03590.10 CDF90261.1 - 0.034 13.5 0.0 0.071 12.5 0.0 1.5 1 0 0 1 1 1 0 Aspartate-ammonia ligase LRR_7 PF13504.1 CDF90261.1 - 0.15 12.3 1.5 12 6.6 0.0 4.7 3 0 0 3 3 3 0 Leucine rich repeat LRR_6 PF13516.1 CDF90261.1 - 0.36 11.0 16.3 2.9 8.2 0.0 7.1 7 1 1 8 8 8 0 Leucine Rich repeat LRR_1 PF00560.28 CDF90261.1 - 1.1 9.5 20.5 1.4 9.1 0.1 8.2 8 1 0 8 8 8 0 Leucine Rich Repeat PUF PF00806.14 CDF90262.1 - 6.4e-29 97.7 0.8 8.1e-05 21.8 0.0 6.6 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat RRM_1 PF00076.17 CDF90262.1 - 6.5e-06 25.6 0.0 1.6e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF90262.1 - 3.6e-05 23.5 0.0 9.1e-05 22.2 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF90262.1 - 0.07 13.1 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Anillin PF08174.6 CDF90263.1 - 1.9e-12 47.3 0.1 2e-11 44.1 0.0 2.8 2 1 1 3 3 3 1 Cell division protein anillin PH PF00169.24 CDF90263.1 - 1.7e-05 24.9 0.2 5.7e-05 23.2 0.0 2.1 2 0 0 2 2 2 1 PH domain Fip1 PF05182.8 CDF90264.1 - 1e-21 75.8 0.8 1e-21 75.8 0.5 1.6 2 0 0 2 2 2 1 Fip1 motif Nop14 PF04147.7 CDF90264.1 - 4.5 5.0 9.9 5 4.9 6.9 1.0 1 0 0 1 1 1 0 Nop14-like family Fungal_trans PF04082.13 CDF90265.1 - 2.4e-30 105.2 2.6 2.4e-30 105.2 1.8 1.9 3 0 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF90265.1 - 2.5e-08 33.6 10.7 4.4e-08 32.9 7.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_L37ae PF01780.14 CDF90267.1 - 1e-38 131.1 9.4 1.1e-38 130.9 6.5 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family DUF1364 PF07102.7 CDF90267.1 - 0.0022 17.8 1.2 0.0028 17.5 0.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1364) Zn_Tnp_IS1595 PF12760.2 CDF90267.1 - 0.003 17.3 2.7 0.0047 16.7 1.9 1.4 1 0 0 1 1 1 1 Transposase zinc-ribbon domain Rep_fac-A_C PF08646.5 CDF90267.1 - 0.0032 17.1 0.3 0.0038 16.9 0.2 1.2 1 0 0 1 1 1 1 Replication factor-A C terminal domain Sgf11 PF08209.6 CDF90267.1 - 0.015 14.6 0.5 0.32 10.3 0.0 2.3 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) zf-H2C2_2 PF13465.1 CDF90267.1 - 0.03 14.6 0.9 1.1 9.6 0.0 2.3 2 0 0 2 2 2 0 Zinc-finger double domain zf-ribbon_3 PF13248.1 CDF90267.1 - 0.043 13.0 1.1 6.1 6.1 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain C1_1 PF00130.17 CDF90267.1 - 0.067 12.9 1.5 0.1 12.3 1.1 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) CarbpepA_inh PF02977.10 CDF90267.1 - 0.082 12.4 3.8 0.16 11.5 0.7 2.1 1 1 1 2 2 2 0 Carboxypeptidase A inhibitor zinc_ribbon_2 PF13240.1 CDF90267.1 - 0.11 12.0 1.5 0.9 9.1 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.6 CDF90267.1 - 0.12 12.0 3.2 0.18 11.4 2.2 1.4 1 1 0 1 1 1 0 Putative transposase DNA-binding domain Elf1 PF05129.8 CDF90267.1 - 0.25 11.0 2.7 0.67 9.6 1.9 1.7 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-BED PF02892.10 CDF90267.1 - 0.44 10.3 4.7 6.6 6.5 0.2 2.3 1 1 1 2 2 2 0 BED zinc finger zf-Sec23_Sec24 PF04810.10 CDF90267.1 - 0.67 9.5 3.6 9 5.9 0.1 2.2 1 1 1 2 2 2 0 Sec23/Sec24 zinc finger Zn-ribbon_8 PF09723.5 CDF90267.1 - 1.4 8.9 3.8 3 7.8 0.2 2.1 1 1 1 2 2 2 0 Zinc ribbon domain zf-C4_ClpX PF06689.8 CDF90267.1 - 5 6.7 8.6 44 3.7 6.0 2.2 1 1 0 1 1 1 0 ClpX C4-type zinc finger Mito_carr PF00153.22 CDF90268.1 - 1.2e-73 242.8 2.6 3.4e-24 84.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Aldo_ket_red PF00248.16 CDF90269.1 - 1.3e-47 161.9 0.0 1.7e-47 161.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family SAC3_GANP PF03399.11 CDF90270.1 - 2.3e-50 171.0 6.4 2.9e-50 170.6 4.5 1.1 1 0 0 1 1 1 1 SAC3/GANP/Nin1/mts3/eIF-3 p25 family COX5A PF02284.11 CDF90270.1 - 0.083 12.8 0.1 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Va Scramblase PF03803.10 CDF90271.1 - 1.4e-68 230.2 0.1 3.3e-67 225.7 0.0 2.0 1 1 0 1 1 1 1 Scramblase Sod_Fe_C PF02777.13 CDF90272.1 - 1.6e-10 40.7 1.8 0.00012 21.8 0.5 2.2 1 1 1 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain ESCRT-II PF05871.7 CDF90273.1 - 1.2e-46 158.0 0.1 1.6e-46 157.6 0.1 1.1 1 0 0 1 1 1 1 ESCRT-II complex subunit TBPIP PF07106.8 CDF90274.1 - 0.11 11.9 5.4 4.8 6.7 1.9 2.5 2 1 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Exonuc_VII_L PF02601.10 CDF90274.1 - 6.9 5.7 8.3 7.6 5.6 5.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit CTP_synth_N PF06418.9 CDF90275.1 - 3e-120 400.4 0.2 4.1e-120 400.0 0.1 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.23 CDF90275.1 - 3.4e-58 196.2 0.0 5.1e-58 195.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 CDF90275.1 - 0.00049 19.6 0.0 0.0031 16.9 0.0 2.3 2 1 0 2 2 2 1 Peptidase C26 CbiA PF01656.18 CDF90275.1 - 0.037 13.4 0.0 0.064 12.6 0.0 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Sod_Cu PF00080.15 CDF90276.1 - 6.4e-45 152.7 3.8 7.4e-45 152.5 2.6 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) DUF3248 PF11609.3 CDF90276.1 - 0.064 12.9 0.0 0.22 11.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3248) DUF2569 PF10754.4 CDF90277.1 - 0.084 13.0 0.0 0.092 12.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) Thioredoxin PF00085.15 CDF90278.1 - 2.8e-07 30.1 0.0 1.7e-06 27.6 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin HyaE PF07449.6 CDF90278.1 - 0.006 16.4 0.1 0.047 13.5 0.0 2.2 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE Thioredoxin_2 PF13098.1 CDF90278.1 - 0.0087 16.2 0.0 0.17 12.1 0.1 2.6 2 1 0 2 2 2 1 Thioredoxin-like domain TraF PF13728.1 CDF90278.1 - 0.025 14.0 0.0 0.11 12.0 0.0 1.9 2 0 0 2 2 2 0 F plasmid transfer operon protein ER_lumen_recept PF00810.13 CDF90279.1 - 2.7e-50 170.6 14.9 4.3e-50 170.0 10.4 1.3 1 0 0 1 1 1 1 ER lumen protein retaining receptor Proteasome PF00227.21 CDF90280.1 - 9.5e-36 122.8 0.1 5e-35 120.5 0.1 1.8 1 1 0 1 1 1 1 Proteasome subunit Transp_cyt_pur PF02133.10 CDF90281.1 - 5e-151 503.1 36.0 5.7e-151 503.0 24.9 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin RNA_pol_Rpb1_7 PF04990.7 CDF90282.1 - 0.064 12.9 2.4 0.19 11.4 0.3 2.0 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb2_45 PF10385.4 CDF90282.1 - 0.07 12.9 0.2 0.17 11.6 0.1 1.7 1 0 0 1 1 1 0 RNA polymerase beta subunit external 1 domain BUD22 PF09073.5 CDF90282.1 - 0.41 9.6 10.1 0.48 9.4 7.0 1.1 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.7 CDF90282.1 - 0.72 9.0 10.0 1 8.5 6.9 1.2 1 0 0 1 1 1 0 SDA1 Peptidase_M16_C PF05193.16 CDF90283.1 - 1.2e-22 80.5 0.0 2.4e-22 79.4 0.0 1.6 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.15 CDF90283.1 - 1.6e-20 73.3 0.1 2.8e-20 72.5 0.1 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Ribosomal_S7 PF00177.16 CDF90285.1 - 8.8e-32 109.7 0.3 1.4e-31 109.1 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e DUF4582 PF15189.1 CDF90285.1 - 0.012 14.9 0.4 0.21 10.7 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4582) EF-hand_4 PF12763.2 CDF90287.1 - 4.5e-27 93.8 0.0 3.1e-08 33.2 0.0 3.7 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.1 CDF90287.1 - 1.1e-10 41.5 0.0 0.017 15.2 0.0 4.0 3 0 0 3 3 3 3 EF-hand domain pair UBA PF00627.26 CDF90287.1 - 4e-09 36.0 0.1 1.2e-08 34.4 0.1 1.9 1 0 0 1 1 1 1 UBA/TS-N domain EF-hand_1 PF00036.27 CDF90287.1 - 9.3e-09 33.9 0.0 0.039 13.2 0.0 4.1 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.1 CDF90287.1 - 1.6e-05 24.3 0.0 1.7 8.7 0.0 4.3 4 0 0 4 4 4 1 EF-hand domain CENP-F_leu_zip PF10473.4 CDF90287.1 - 5e-05 23.1 44.2 0.00024 20.9 15.9 3.0 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.1 CDF90287.1 - 0.00064 18.3 30.3 0.00064 18.3 21.0 2.2 1 1 1 2 2 2 1 AAA domain IncA PF04156.9 CDF90287.1 - 0.00071 19.2 25.9 0.00071 19.2 18.0 3.7 2 1 0 3 3 3 1 IncA protein DUF3584 PF12128.3 CDF90287.1 - 0.0021 15.4 44.5 0.0033 14.8 30.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) BLOC1_2 PF10046.4 CDF90287.1 - 0.0033 17.5 33.8 0.092 12.8 5.8 3.9 2 1 1 3 3 3 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 UBA_4 PF14555.1 CDF90287.1 - 0.0037 16.7 0.1 0.0091 15.5 0.0 1.7 1 0 0 1 1 1 1 UBA-like domain Laminin_I PF06008.9 CDF90287.1 - 2.2 7.5 48.2 0.45 9.7 13.3 3.6 2 1 0 3 3 3 0 Laminin Domain I Reo_sigmaC PF04582.7 CDF90287.1 - 4.7 6.3 22.8 0.33 10.0 8.8 2.8 2 1 0 3 3 3 0 Reovirus sigma C capsid protein Filament PF00038.16 CDF90287.1 - 5.9 6.2 49.1 5.1 6.4 11.3 3.3 1 1 2 3 3 3 0 Intermediate filament protein Nup54 PF13874.1 CDF90287.1 - 9.7 5.8 40.5 0.65 9.6 8.9 3.5 1 1 2 3 3 3 0 Nucleoporin complex subunit 54 Nnf1 PF03980.9 CDF90288.1 - 9.9e-30 102.7 3.9 1.8e-29 101.8 2.7 1.5 1 0 0 1 1 1 1 Nnf1 DUF342 PF03961.8 CDF90288.1 - 0.0026 16.2 2.2 0.0037 15.7 1.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF342) MscS_porin PF12795.2 CDF90288.1 - 0.0045 16.3 2.1 0.0045 16.3 1.5 2.4 2 1 1 3 3 3 1 Mechanosensitive ion channel porin domain DUF848 PF05852.6 CDF90288.1 - 0.0069 16.2 6.2 0.026 14.3 0.5 2.4 2 1 1 3 3 3 1 Gammaherpesvirus protein of unknown function (DUF848) DUF4600 PF15372.1 CDF90288.1 - 0.031 14.4 1.2 0.031 14.4 0.8 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4600) TMF_DNA_bd PF12329.3 CDF90288.1 - 0.053 13.3 1.5 0.053 13.3 1.0 3.0 4 0 0 4 4 3 0 TATA element modulatory factor 1 DNA binding DUF2853 PF11015.3 CDF90288.1 - 0.056 13.9 1.4 0.06 13.8 0.3 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF2853) DUF4375 PF14300.1 CDF90288.1 - 0.079 12.9 4.4 1.2 9.0 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4375) DUF1664 PF07889.7 CDF90288.1 - 0.12 12.1 4.0 0.58 9.9 1.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Ta0938 PF11494.3 CDF90288.1 - 0.13 12.4 0.7 1.2 9.2 0.1 2.2 1 1 1 2 2 2 0 Ta0938 Cluap1 PF10234.4 CDF90288.1 - 0.33 10.1 4.2 4.8 6.3 0.8 2.2 2 0 0 2 2 2 0 Clusterin-associated protein-1 DUF3552 PF12072.3 CDF90288.1 - 0.39 9.9 7.2 1.7 7.7 1.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) Laminin_II PF06009.7 CDF90288.1 - 0.82 9.4 4.2 14 5.3 0.2 2.8 2 1 1 3 3 3 0 Laminin Domain II PilO PF04350.8 CDF90288.1 - 0.86 9.4 4.1 14 5.5 0.1 2.9 1 1 2 3 3 3 0 Pilus assembly protein, PilO THOC7 PF05615.8 CDF90288.1 - 0.9 9.8 9.5 2.8 8.2 1.1 3.0 2 1 1 3 3 3 0 Tho complex subunit 7 V-SNARE PF05008.10 CDF90288.1 - 1.5 9.0 6.7 1.8 8.7 0.1 2.8 3 0 0 3 3 2 0 Vesicle transport v-SNARE protein N-terminus bZIP_2 PF07716.10 CDF90288.1 - 3 7.7 8.5 1.2 9.0 0.8 2.8 2 0 0 2 2 2 0 Basic region leucine zipper BLOC1_2 PF10046.4 CDF90288.1 - 3.5 7.8 9.5 1.2 9.2 1.0 2.9 2 2 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Prefoldin PF02996.12 CDF90288.1 - 5.9 6.5 9.1 3.1 7.4 1.1 3.1 2 1 1 3 3 3 0 Prefoldin subunit DUF4404 PF14357.1 CDF90288.1 - 6.2 7.3 8.5 2.9 8.3 1.6 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) ATG16 PF08614.6 CDF90288.1 - 7.2 6.3 13.6 6.9 6.4 3.1 2.6 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) CMD PF02627.15 CDF90289.1 - 1.5e-06 27.9 0.0 4.2e-06 26.4 0.0 1.7 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family Myotub-related PF06602.9 CDF90290.1 - 9.8e-129 429.1 0.4 1.2e-128 428.8 0.3 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.15 CDF90290.1 - 0.0026 17.2 0.1 0.0071 15.8 0.0 1.7 1 0 0 1 1 1 1 GRAM domain Y_phosphatase3 PF13350.1 CDF90290.1 - 0.0029 17.8 0.0 0.0065 16.7 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 CDF90290.1 - 0.014 14.7 0.0 0.031 13.6 0.0 1.5 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DSPc PF00782.15 CDF90290.1 - 0.054 13.0 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Yippee-Mis18 PF03226.9 CDF90291.1 - 1.3e-15 57.1 5.8 1.7e-15 56.8 4.0 1.2 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly SNAP PF14938.1 CDF90292.1 - 1.5e-104 349.1 7.5 1.7e-104 348.9 5.2 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.1 CDF90292.1 - 1.3e-05 25.0 12.8 0.0042 16.9 0.5 2.9 3 1 0 3 3 3 2 Tetratricopeptide repeat Foie-gras_1 PF11817.3 CDF90292.1 - 9e-05 22.0 3.4 0.00027 20.4 1.1 2.2 1 1 1 2 2 2 2 Foie gras liver health family 1 TPR_1 PF00515.23 CDF90292.1 - 0.0012 18.4 8.1 0.62 9.7 0.0 4.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.1 CDF90292.1 - 0.0058 16.3 1.9 0.059 13.1 0.1 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.12 CDF90292.1 - 0.009 15.8 10.0 2.2 8.3 0.0 5.2 4 1 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.1 CDF90292.1 - 0.019 14.6 13.6 0.038 13.6 0.0 3.6 1 1 2 3 3 3 0 TPR repeat TPR_6 PF13174.1 CDF90292.1 - 0.041 14.3 11.0 25 5.5 0.1 5.3 4 1 0 4 4 4 0 Tetratricopeptide repeat DUF2225 PF09986.4 CDF90292.1 - 0.066 12.6 3.9 6.2 6.2 2.7 2.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) NSF PF02071.15 CDF90292.1 - 0.073 13.6 11.9 7.7 7.5 0.2 5.8 6 0 0 6 6 6 0 Aromatic-di-Alanine (AdAR) repeat TPR_8 PF13181.1 CDF90292.1 - 0.074 12.8 8.1 8 6.5 0.0 4.3 4 1 1 5 5 5 0 Tetratricopeptide repeat Spatacsin_C PF14649.1 CDF90292.1 - 0.11 11.3 3.3 0.33 9.7 0.6 2.3 1 1 0 2 2 2 0 Spatacsin C-terminus TPR_19 PF14559.1 CDF90292.1 - 0.38 11.1 9.6 0.69 10.2 1.2 3.8 3 1 1 4 4 4 0 Tetratricopeptide repeat CPSase_L_D2 PF02786.12 CDF90293.1 - 2.7e-109 363.3 0.0 3e-84 281.5 0.0 2.5 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.14 CDF90293.1 - 6.5e-38 129.2 0.4 1.3e-37 128.2 0.1 1.8 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp_4 PF13535.1 CDF90293.1 - 3.9e-37 127.7 0.6 1e-18 67.7 0.0 3.1 3 0 0 3 3 3 2 ATP-grasp domain CPSase_L_chain PF00289.17 CDF90293.1 - 1.5e-34 118.3 0.0 2.4e-16 59.7 0.0 2.7 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, N-terminal domain ATPgrasp_Ter PF15632.1 CDF90293.1 - 8.1e-21 74.1 0.0 2e-06 26.8 0.0 3.7 3 1 0 3 3 3 3 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 CDF90293.1 - 8.9e-19 67.4 0.1 1.2e-08 34.5 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.8 CDF90293.1 - 5.5e-14 52.0 0.2 2e-06 27.3 0.0 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus RimK PF08443.6 CDF90293.1 - 4.2e-07 29.6 0.1 0.016 14.6 0.0 2.5 2 0 0 2 2 2 2 RimK-like ATP-grasp domain MGS PF02142.17 CDF90293.1 - 6.1e-06 26.0 0.0 3.8e-05 23.5 0.0 2.4 2 0 0 2 2 2 1 MGS-like domain Epimerase PF01370.16 CDF90293.1 - 0.00069 19.1 0.0 0.039 13.3 0.0 2.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family ATP-grasp_5 PF13549.1 CDF90293.1 - 0.0073 15.5 0.1 0.67 9.1 0.1 2.7 2 0 0 2 2 2 1 ATP-grasp domain NAD_binding_5 PF07994.7 CDF90294.1 - 3.1e-112 374.8 0.1 3.7e-112 374.6 0.1 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.12 CDF90294.1 - 5.6e-43 145.3 1.4 1.1e-42 144.4 0.5 1.9 2 0 0 2 2 2 1 Myo-inositol-1-phosphate synthase peroxidase PF00141.18 CDF90295.1 - 3.4e-41 141.2 0.0 5.5e-41 140.5 0.0 1.3 1 0 0 1 1 1 1 Peroxidase Vps35 PF03635.12 CDF90296.1 - 1.4e-272 906.3 21.3 1.7e-272 906.1 14.7 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 6PF2K PF01591.13 CDF90297.1 - 2.7e-85 284.9 0.4 3.5e-85 284.5 0.3 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 CDF90297.1 - 1.5e-32 112.9 0.0 2.8e-32 111.9 0.0 1.5 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 CDF90297.1 - 3.2e-06 27.0 0.0 6.1e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CDF90297.1 - 0.00024 21.9 0.4 0.0014 19.3 0.1 2.4 2 1 0 2 2 2 1 AAA domain KTI12 PF08433.5 CDF90297.1 - 0.057 12.6 0.0 0.094 11.8 0.0 1.4 1 1 0 1 1 1 0 Chromatin associated protein KTI12 zf-RING_2 PF13639.1 CDF90299.1 - 0.00038 20.2 4.1 0.00038 20.2 2.8 2.3 3 0 0 3 3 3 1 Ring finger domain PIR PF00399.14 CDF90301.1 - 4.1e-51 168.6 112.1 9.6e-08 31.1 7.4 9.4 8 0 0 8 8 8 8 Yeast PIR protein repeat DUF1989 PF09347.5 CDF90303.1 - 3.7e-53 179.3 0.0 4.7e-53 179.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) DnaJ PF00226.26 CDF90305.1 - 5.7e-20 70.8 2.3 1.1e-19 69.8 0.7 2.2 1 1 1 2 2 2 1 DnaJ domain PigN PF04987.9 CDF90306.1 - 2.4e-131 438.4 43.1 3.1e-131 438.0 29.9 1.1 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.17 CDF90306.1 - 1.8e-14 53.8 0.4 6e-09 35.7 0.0 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.18 CDF90306.1 - 8.5e-09 35.0 0.0 1.9e-08 33.8 0.0 1.6 1 1 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.13 CDF90306.1 - 0.00071 19.0 0.0 0.0015 17.9 0.0 1.5 1 0 0 1 1 1 1 Metalloenzyme superfamily MFS_1 PF07690.11 CDF90307.1 - 1.2e-16 60.3 17.2 1.2e-16 60.3 11.9 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.20 CDF90308.1 - 4.3e-71 239.1 0.0 6.7e-71 238.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF90308.1 - 1.1e-39 136.0 0.0 1.7e-39 135.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF90308.1 - 0.00056 18.9 0.0 0.00093 18.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.4 CDF90308.1 - 0.026 13.8 0.0 0.073 12.4 0.0 1.7 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.18 CDF90308.1 - 0.048 13.3 0.0 0.12 12.1 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family CDC45 PF02724.9 CDF90308.1 - 3.3 5.6 8.5 4.2 5.2 5.9 1.1 1 0 0 1 1 1 0 CDC45-like protein L51_S25_CI-B8 PF05047.11 CDF90309.1 - 3.1e-10 39.6 0.0 6.1e-10 38.6 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain GPW_gp25 PF04965.9 CDF90309.1 - 0.078 12.5 0.0 2.9 7.5 0.0 2.1 2 0 0 2 2 2 0 Gene 25-like lysozyme LrgB PF04172.11 CDF90310.1 - 4.3e-23 81.5 3.0 4.3e-23 81.5 2.1 2.9 4 0 0 4 4 4 1 LrgB-like family LrgA PF03788.9 CDF90310.1 - 0.084 12.5 6.7 0.029 14.0 2.0 2.3 2 0 0 2 2 2 0 LrgA family Pkinase PF00069.20 CDF90311.1 - 3.7e-46 157.3 0.0 6e-46 156.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF90311.1 - 2.6e-16 59.4 0.0 4.8e-16 58.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Ribosomal_L14 PF00238.14 CDF90312.1 - 1.3e-41 141.1 1.5 1.5e-41 141.0 1.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Pkinase PF00069.20 CDF90313.1 - 9.2e-40 136.4 0.0 1.3e-25 90.0 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDF90313.1 - 2.7e-20 72.5 0.0 1.9e-16 59.8 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 CDF90313.1 - 0.006 15.5 0.0 1.4 7.8 0.0 2.5 2 0 0 2 2 2 2 Kinase-like DUF3338 PF11819.3 CDF90313.1 - 0.082 12.3 0.0 0.27 10.6 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3338) APH PF01636.18 CDF90313.1 - 0.15 11.7 0.0 0.28 10.8 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family UcrQ PF02939.11 CDF90314.1 - 7.9e-36 121.7 0.4 9e-36 121.5 0.3 1.0 1 0 0 1 1 1 1 UcrQ family DUF2741 PF10890.3 CDF90314.1 - 0.029 14.4 0.0 0.04 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2741) polyprenyl_synt PF00348.12 CDF90315.1 - 3.6e-84 281.6 0.0 4.3e-84 281.4 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Ebp2 PF05890.7 CDF90316.1 - 1.6e-82 276.8 23.5 1.6e-82 276.8 16.3 2.9 1 1 2 3 3 3 1 Eukaryotic rRNA processing protein EBP2 GTP_EFTU PF00009.22 CDF90317.1 - 5e-34 117.3 0.0 7.3e-34 116.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 CDF90317.1 - 1.5e-19 69.6 0.0 3.1e-19 68.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.19 CDF90317.1 - 8.1e-14 51.2 0.0 2e-13 50.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.18 CDF90317.1 - 8e-05 22.5 0.0 0.00015 21.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.1 CDF90317.1 - 0.00012 21.8 0.0 0.00026 20.7 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II Miro PF08477.8 CDF90317.1 - 0.00027 21.4 0.0 0.00057 20.3 0.0 1.6 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU_D2 PF03144.20 CDF90317.1 - 0.00059 19.9 0.0 0.0012 18.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Ras PF00071.17 CDF90317.1 - 0.0037 16.6 0.0 0.015 14.6 0.0 2.0 1 1 0 1 1 1 1 Ras family Dynamin_N PF00350.18 CDF90317.1 - 0.036 13.8 0.1 7.6 6.3 0.0 2.3 1 1 1 2 2 2 0 Dynamin family AA_permease PF00324.16 CDF90318.1 - 1.8e-73 247.5 37.5 2.3e-73 247.1 26.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CDF90318.1 - 1.5e-37 129.1 41.7 2e-37 128.7 28.9 1.1 1 0 0 1 1 1 1 Amino acid permease Zip PF02535.17 CDF90319.1 - 5.7e-25 87.9 9.7 5.7e-25 87.9 6.7 1.9 1 1 1 2 2 2 1 ZIP Zinc transporter H_PPase PF03030.11 CDF90319.1 - 0.045 12.0 0.0 0.07 11.3 0.0 1.2 1 0 0 1 1 1 0 Inorganic H+ pyrophosphatase DUF3816 PF12822.2 CDF90319.1 - 0.36 10.6 4.3 0.96 9.3 0.2 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3816) ABC2_membrane_5 PF13346.1 CDF90319.1 - 1 8.6 8.1 3 7.1 1.0 2.2 2 0 0 2 2 2 0 ABC-2 family transporter protein SRI PF08236.6 CDF90321.1 - 2.5e-26 91.4 7.5 2.5e-26 91.4 5.2 3.3 4 0 0 4 4 4 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.23 CDF90321.1 - 3e-20 73.1 0.2 3e-20 73.1 0.1 3.5 2 2 0 2 2 2 1 SET domain WW PF00397.21 CDF90321.1 - 0.041 13.7 0.0 0.085 12.7 0.0 1.5 1 0 0 1 1 1 0 WW domain DUF4633 PF15464.1 CDF90321.1 - 0.3 10.9 3.9 0.73 9.6 2.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4633) DUF4410 PF14366.1 CDF90321.1 - 1.5 8.5 5.2 56 3.4 3.0 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4410) Glyco_transf_29 PF00777.13 CDF90322.1 - 0.12 11.5 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 29 (sialyltransferase) DUF2401 PF10287.4 CDF90323.1 - 1.5e-91 306.0 3.7 2.1e-91 305.6 2.5 1.1 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.4 CDF90323.1 - 1.8e-23 82.4 0.1 4.9e-23 81.0 0.1 1.8 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) STE3 PF02076.10 CDF90324.1 - 5.7e-92 307.7 25.4 7.2e-92 307.4 17.6 1.1 1 0 0 1 1 1 1 Pheromone A receptor Peptidase_M20 PF01546.23 CDF90325.1 - 4.3e-24 85.0 0.0 5.9e-24 84.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 CDF90325.1 - 1.2e-11 44.2 0.0 4.3e-11 42.5 0.0 1.9 1 1 0 1 1 1 1 Peptidase dimerisation domain Rep_fac-A_3 PF08661.6 CDF90326.1 - 5.4e-28 97.0 0.0 6e-28 96.9 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 E1_DerP2_DerF2 PF02221.10 CDF90326.1 - 0.14 12.3 0.0 0.18 12.0 0.0 1.2 1 0 0 1 1 1 0 ML domain KRE9 PF05390.6 CDF90327.1 - 1.7e-44 150.5 10.0 5e-44 149.0 6.9 1.7 1 0 0 1 1 1 1 Yeast cell wall synthesis protein KRE9/KNH1 GPI-anchored PF10342.4 CDF90327.1 - 8.5e-09 35.7 2.3 8.5e-09 35.7 1.6 2.4 2 1 1 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Wzt_C PF14524.1 CDF90327.1 - 0.025 14.2 0.0 0.043 13.4 0.0 1.4 1 0 0 1 1 1 0 Wzt C-terminal domain HECT PF00632.20 CDF90328.1 - 3.9e-91 305.5 0.0 5.4e-91 305.0 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.21 CDF90328.1 - 5.5e-34 115.6 19.7 6.7e-11 41.8 1.0 3.7 3 0 0 3 3 3 3 WW domain C2 PF00168.25 CDF90328.1 - 1.7e-15 56.6 0.3 4.3e-15 55.3 0.2 1.7 1 0 0 1 1 1 1 C2 domain RAP1 PF07218.6 CDF90328.1 - 0.18 9.8 7.4 0.29 9.1 5.2 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF2550 PF10739.4 CDF90329.1 - 0.044 13.7 0.4 0.55 10.1 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2550) PUF PF00806.14 CDF90330.1 - 3.6e-56 183.6 31.5 5e-08 31.9 0.1 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Ribosomal_S8e PF01201.17 CDF90331.1 - 3e-39 134.1 9.1 6e-39 133.2 6.3 1.5 1 1 0 1 1 1 1 Ribosomal protein S8e HPD PF05044.7 CDF90331.1 - 0.012 15.2 0.1 0.025 14.2 0.0 1.4 1 0 0 1 1 1 0 Homeo-prospero domain AAA_13 PF13166.1 CDF90331.1 - 1.3 7.4 6.0 1.6 7.0 4.2 1.0 1 0 0 1 1 1 0 AAA domain DUF3959 PF13105.1 CDF90331.1 - 5.2 6.3 7.7 2.1 7.6 0.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3959) Sas10_Utp3 PF04000.10 CDF90332.1 - 1.1e-09 38.2 0.9 1.1e-09 38.2 0.6 2.3 2 0 0 2 2 2 1 Sas10/Utp3/C1D family DUF2935 PF11155.3 CDF90332.1 - 0.057 13.5 0.2 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) Vfa1 PF08432.5 CDF90333.1 - 1.3e-35 123.0 16.5 6.5e-34 117.5 11.4 2.0 1 1 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 Mononeg_RNA_pol PF00946.14 CDF90333.1 - 0.15 9.3 3.4 0.16 9.2 2.4 1.0 1 0 0 1 1 1 0 Mononegavirales RNA dependent RNA polymerase Rsc14 PF08586.5 CDF90333.1 - 0.31 11.5 2.7 0.56 10.7 1.8 1.5 1 0 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit DUF1428 PF07237.6 CDF90333.1 - 0.69 9.8 3.4 3.4 7.6 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1428) NDUFA12 PF05071.11 CDF90333.1 - 1.3 9.5 5.6 4.2 7.8 3.9 1.9 1 1 0 1 1 1 0 NADH ubiquinone oxidoreductase subunit NDUFA12 DUF2756 PF10956.3 CDF90333.1 - 2.4 8.4 7.4 3.9 7.7 5.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2756) Pkinase PF00069.20 CDF90334.1 - 1.2e-48 165.5 0.0 2e-48 164.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF90334.1 - 6.5e-24 84.3 0.0 3.1e-23 82.1 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF90334.1 - 1.8e-05 23.8 0.0 3.8e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like DUF3543 PF12063.3 CDF90335.1 - 1.4e-64 217.5 7.0 3.6e-64 216.2 4.8 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase PF00069.20 CDF90335.1 - 2.3e-59 200.6 0.0 7e-59 199.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF90335.1 - 1.1e-44 152.4 0.0 1.9e-44 151.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF90335.1 - 0.011 14.6 0.1 0.2 10.5 0.0 2.5 3 0 0 3 3 3 0 Kinase-like DUF3924 PF13062.1 CDF90335.1 - 0.046 13.5 0.4 13 5.7 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3924) APH PF01636.18 CDF90335.1 - 0.1 12.3 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family ArfGap PF01412.13 CDF90336.1 - 1.2e-28 99.2 0.1 1.2e-28 99.2 0.0 3.1 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf PAT1 PF09770.4 CDF90336.1 - 0.0066 14.7 54.8 0.0079 14.4 38.0 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Mnd1 PF03962.10 CDF90337.1 - 2.4e-51 174.1 9.9 2.7e-51 173.9 6.9 1.0 1 0 0 1 1 1 1 Mnd1 family FCD PF07729.7 CDF90337.1 - 0.0017 18.6 2.2 0.0026 18.0 1.5 1.3 1 0 0 1 1 1 1 FCD domain Psb28 PF03912.9 CDF90337.1 - 0.025 14.5 1.0 0.17 11.8 0.1 2.4 1 1 1 2 2 2 0 Psb28 protein WXG100 PF06013.7 CDF90337.1 - 0.3 11.1 6.3 24 5.0 0.1 3.3 2 1 1 3 3 3 0 Proteins of 100 residues with WXG MerR-DNA-bind PF09278.6 CDF90337.1 - 2.7 8.4 11.7 12 6.3 1.4 3.2 2 1 1 3 3 3 0 MerR, DNA binding Prefoldin_2 PF01920.15 CDF90337.1 - 8.4 6.2 10.7 5.6 6.7 0.1 3.3 2 1 1 3 3 3 0 Prefoldin subunit zf-C2H2 PF00096.21 CDF90338.1 - 2.1e-13 49.7 11.2 8.2e-07 29.0 0.6 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CDF90338.1 - 1.3e-10 40.8 8.9 2e-05 24.5 0.3 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CDF90338.1 - 1.8e-09 37.4 7.5 0.00014 21.8 0.2 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CDF90338.1 - 1.4e-05 25.0 4.6 0.032 14.4 0.6 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.1 CDF90338.1 - 3.5e-05 23.8 17.4 6.6e-05 22.9 3.2 3.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-Di19 PF05605.7 CDF90338.1 - 0.00086 19.3 6.8 0.0014 18.7 4.7 1.3 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.10 CDF90338.1 - 0.0048 16.6 7.6 0.64 9.8 0.9 2.6 1 1 1 2 2 2 2 BED zinc finger zf-C2H2_6 PF13912.1 CDF90338.1 - 0.0068 16.2 6.4 0.013 15.3 0.4 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_2 PF12756.2 CDF90338.1 - 0.026 14.6 8.0 0.42 10.7 1.1 2.3 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Prok-RING_4 PF14447.1 CDF90338.1 - 0.097 12.2 1.7 0.42 10.2 0.1 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C2HC_2 PF13913.1 CDF90338.1 - 0.1 12.2 6.8 1.1 9.0 0.2 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-CHCC PF10276.4 CDF90338.1 - 0.78 9.6 4.8 0.31 10.9 0.2 2.2 2 0 0 2 2 2 0 Zinc-finger domain zf-DBF PF07535.7 CDF90338.1 - 2.4 7.9 5.8 0.85 9.3 0.2 2.3 2 0 0 2 2 2 0 DBF zinc finger FYDLN_acid PF09538.5 CDF90338.1 - 5.7 7.5 9.3 13 6.4 1.5 2.9 3 0 0 3 3 2 0 Protein of unknown function (FYDLN_acid) Cys_Met_Meta_PP PF01053.15 CDF90339.1 - 5.8e-122 406.6 0.0 6.8e-122 406.4 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Met_gamma_lyase PF06838.6 CDF90339.1 - 0.0015 16.9 0.0 0.0021 16.4 0.0 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase GDC-P PF02347.11 CDF90339.1 - 0.012 14.3 0.0 0.018 13.7 0.0 1.1 1 0 0 1 1 1 0 Glycine cleavage system P-protein 2-Hacid_dh_C PF02826.14 CDF90340.1 - 1.7e-29 102.2 0.0 2.5e-29 101.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.11 CDF90340.1 - 0.00054 19.4 0.0 0.001 18.5 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 2-Hacid_dh PF00389.25 CDF90340.1 - 0.00057 19.3 0.0 0.0087 15.5 0.0 2.1 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 CDF90340.1 - 0.0089 15.8 0.0 0.014 15.2 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase DUF1513 PF07433.6 CDF90340.1 - 0.09 11.6 0.0 0.17 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1513) COX5B PF01215.14 CDF90341.1 - 2.1e-51 173.1 0.0 2.4e-51 172.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb Ribosomal_S26e PF01283.14 CDF90342.1 - 4.7e-50 168.5 9.8 5.6e-50 168.3 6.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e DUF1101 PF06503.6 CDF90342.1 - 0.044 12.5 0.1 0.049 12.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1101) WD40 PF00400.27 CDF90343.1 - 1.9e-17 62.4 2.2 0.0015 18.3 0.1 7.3 7 0 0 7 7 7 5 WD domain, G-beta repeat COX6A PF02046.10 CDF90344.1 - 1.8e-40 137.4 1.7 1.9e-40 137.3 1.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa MT-A70 PF05063.9 CDF90345.1 - 2e-53 180.5 0.7 3.7e-53 179.6 0.1 1.7 2 0 0 2 2 2 1 MT-A70 Glyco_hydro_30 PF02055.11 CDF90345.1 - 0.1 10.7 0.0 0.21 9.7 0.0 1.4 1 1 0 1 1 1 0 O-Glycosyl hydrolase family 30 Hist_deacetyl PF00850.14 CDF90346.1 - 3.8e-81 272.7 0.0 4.8e-81 272.4 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Zn_clus PF00172.13 CDF90347.1 - 2.2e-09 37.0 10.6 4.8e-09 35.9 7.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.3 CDF90347.1 - 4.2e-06 25.6 0.2 7.2e-06 24.8 0.1 1.4 2 0 0 2 2 2 1 Fungal specific transcription factor domain DUF3554 PF12074.3 CDF90349.1 - 4.8e-40 138.0 19.4 5.7e-40 137.7 1.9 5.9 6 2 0 6 6 6 1 Domain of unknown function (DUF3554) HEAT_2 PF13646.1 CDF90349.1 - 2.9e-38 130.0 24.9 3.1e-08 33.7 0.0 14.1 8 3 5 15 15 15 10 HEAT repeats HEAT PF02985.17 CDF90349.1 - 8.9e-32 106.3 20.0 0.0018 18.1 0.0 19.3 22 0 0 22 22 22 8 HEAT repeat HEAT_EZ PF13513.1 CDF90349.1 - 2.7e-29 100.8 34.0 0.0015 18.9 0.1 19.5 20 3 6 26 26 26 9 HEAT-like repeat CLASP_N PF12348.3 CDF90349.1 - 2.4e-17 63.0 4.0 0.00051 19.4 0.0 8.5 6 1 4 10 10 10 4 CLASP N terminal Vac14_Fab1_bd PF12755.2 CDF90349.1 - 1.6e-12 47.6 1.2 0.11 12.9 0.0 9.7 10 1 1 11 11 11 3 Vacuolar 14 Fab1-binding region D-ser_dehydrat PF14031.1 CDF90350.1 - 1.3e-19 70.1 0.0 2.2e-18 66.2 0.0 2.6 3 0 0 3 3 3 1 Putative serine dehydratase domain Ala_racemase_N PF01168.15 CDF90350.1 - 6.3e-09 35.7 0.0 9.3e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Kelch_4 PF13418.1 CDF90351.1 - 4.6e-15 55.1 0.3 0.00021 20.9 0.0 5.8 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.1 CDF90351.1 - 5.8e-13 48.3 0.7 1.1e-05 25.3 0.0 5.1 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.1 CDF90351.1 - 1.2e-12 47.5 0.3 0.0026 17.8 0.0 6.1 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.20 CDF90351.1 - 9.1e-12 44.3 0.0 6.7e-05 22.3 0.0 4.4 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.10 CDF90351.1 - 7.9e-07 28.6 0.2 0.00037 20.1 0.0 3.7 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.1 CDF90351.1 - 0.022 14.7 0.0 0.22 11.5 0.0 2.7 2 0 0 2 2 2 0 Kelch motif Yip1 PF04893.12 CDF90352.1 - 1.4e-08 34.4 8.5 1.6e-08 34.2 5.9 1.2 1 0 0 1 1 1 1 Yip1 domain Metallophos PF00149.23 CDF90353.1 - 2.6e-44 151.0 0.1 3.1e-44 150.7 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase EMP24_GP25L PF01105.19 CDF90354.1 - 2.2e-43 148.1 0.0 2.5e-43 147.9 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD MASE1 PF05231.9 CDF90355.1 - 0.011 14.7 0.1 0.012 14.6 0.1 1.1 1 0 0 1 1 1 0 MASE1 PWWP PF00855.12 CDF90357.1 - 7.4e-16 58.1 0.0 2.2e-15 56.6 0.0 1.8 1 0 0 1 1 1 1 PWWP domain Pyridox_oxidase PF01243.15 CDF90358.1 - 6.2e-18 64.5 0.1 2.2e-17 62.8 0.0 1.8 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Pyrid_oxidase_2 PF13883.1 CDF90358.1 - 1.2e-05 25.1 0.2 3e-05 23.8 0.1 1.5 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase USP8_dimer PF08969.6 CDF90358.1 - 0.041 13.8 0.0 0.081 12.8 0.0 1.4 1 0 0 1 1 1 0 USP8 dimerisation domain Glyco_transf_5 PF08323.6 CDF90358.1 - 0.099 12.1 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Starch synthase catalytic domain AAA PF00004.24 CDF90359.1 - 1.9e-43 147.8 0.0 3.2e-43 147.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.5 CDF90359.1 - 5.4e-28 96.6 0.0 5e-27 93.5 0.0 2.4 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain MIT PF04212.13 CDF90359.1 - 3.8e-21 74.7 2.0 3.8e-21 74.7 1.4 2.5 3 0 0 3 3 2 1 MIT (microtubule interacting and transport) domain AAA_17 PF13207.1 CDF90359.1 - 3.5e-06 27.8 0.1 1.5e-05 25.8 0.0 2.1 3 0 0 3 3 1 1 AAA domain AAA_22 PF13401.1 CDF90359.1 - 3.7e-06 27.0 0.1 0.0012 19.0 0.1 3.0 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.9 CDF90359.1 - 1.1e-05 25.2 0.0 5.4e-05 22.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 CDF90359.1 - 1.8e-05 23.8 0.0 2.9e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus DUF815 PF05673.8 CDF90359.1 - 2.8e-05 23.1 0.0 0.00011 21.2 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF815) AAA_25 PF13481.1 CDF90359.1 - 2.9e-05 23.5 0.1 0.036 13.4 0.0 2.3 1 1 1 2 2 2 2 AAA domain AAA_16 PF13191.1 CDF90359.1 - 2.9e-05 24.1 0.0 0.00032 20.7 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.1 CDF90359.1 - 3e-05 23.9 0.0 8.1e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 CDF90359.1 - 3.3e-05 23.3 0.0 7.1e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.17 CDF90359.1 - 0.00016 21.8 0.1 0.0075 16.4 0.0 2.8 3 0 0 3 3 2 1 RNA helicase TIP49 PF06068.8 CDF90359.1 - 0.00025 19.8 0.0 0.0004 19.2 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_2 PF07724.9 CDF90359.1 - 0.00047 20.1 0.0 0.0017 18.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.1 CDF90359.1 - 0.00052 19.9 0.1 0.0017 18.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 CDF90359.1 - 0.0042 16.2 0.2 0.11 11.5 0.0 2.5 2 1 0 2 2 2 1 Zeta toxin AAA_18 PF13238.1 CDF90359.1 - 0.0074 16.5 0.0 0.02 15.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 CDF90359.1 - 0.016 14.8 0.0 0.03 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 CDF90359.1 - 0.023 14.4 0.0 0.054 13.2 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain Arch_ATPase PF01637.13 CDF90359.1 - 0.025 14.2 0.1 0.45 10.1 0.0 2.3 1 1 1 2 2 2 0 Archaeal ATPase Mg_chelatase PF01078.16 CDF90359.1 - 0.028 13.5 0.0 0.063 12.4 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PhoH PF02562.11 CDF90359.1 - 0.036 13.3 0.0 0.061 12.5 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein KaiC PF06745.8 CDF90359.1 - 0.036 13.1 0.1 4.2 6.4 0.0 2.3 1 1 1 2 2 2 0 KaiC Torsin PF06309.6 CDF90359.1 - 0.04 13.8 0.0 0.08 12.8 0.0 1.4 1 0 0 1 1 1 0 Torsin NACHT PF05729.7 CDF90359.1 - 0.044 13.4 0.0 0.62 9.6 0.0 2.2 1 1 1 2 2 2 0 NACHT domain AAA_21 PF13304.1 CDF90359.1 - 0.077 12.9 0.2 2.3 8.1 0.0 2.4 1 1 1 2 2 2 0 AAA domain Parvo_NS1 PF01057.12 CDF90359.1 - 0.086 11.7 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.21 CDF90359.1 - 0.087 12.2 0.0 0.28 10.6 0.0 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain Sigma54_activ_2 PF14532.1 CDF90359.1 - 0.11 12.5 0.0 0.28 11.2 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_28 PF13521.1 CDF90359.1 - 0.12 12.3 0.0 0.28 11.1 0.0 1.7 2 0 0 2 2 1 0 AAA domain CPT PF07931.7 CDF90359.1 - 0.15 11.6 0.0 0.29 10.7 0.0 1.6 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein NBP1 PF08537.5 CDF90360.1 - 7.7e-103 344.0 13.9 8.6e-103 343.9 9.6 1.0 1 0 0 1 1 1 1 Fungal Nap binding protein NBP1 IncA PF04156.9 CDF90360.1 - 0.13 11.8 6.0 0.24 10.9 4.1 1.5 1 0 0 1 1 1 0 IncA protein DNA_pol_E_B PF04042.11 CDF90361.1 - 2.3e-50 170.7 1.2 3.8e-50 170.0 0.8 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Prenyltrans PF00432.16 CDF90362.1 - 7.1e-60 198.2 6.1 3.5e-14 52.0 0.2 6.1 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Prenyltrans_2 PF13249.1 CDF90362.1 - 4.5e-24 85.0 0.0 7.5e-12 45.6 0.0 4.0 1 1 3 4 4 4 4 Prenyltransferase-like Prenyltrans_1 PF13243.1 CDF90362.1 - 2e-09 37.4 0.0 0.0059 16.6 0.0 3.2 1 1 3 4 4 4 4 Prenyltransferase-like A2M_comp PF07678.9 CDF90362.1 - 0.0011 18.2 0.0 0.3 10.2 0.0 3.5 4 0 0 4 4 4 1 A-macroglobulin complement component WD40 PF00400.27 CDF90363.1 - 3e-47 156.8 14.2 7.9e-14 50.9 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 CDF90363.1 - 0.00018 21.2 0.1 0.31 10.7 0.0 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A HDA2-3 PF11496.3 CDF90364.1 - 5e-84 281.6 1.9 5e-84 281.6 1.3 1.9 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 Reo_sigmaC PF04582.7 CDF90364.1 - 0.53 9.4 4.8 1.1 8.3 2.2 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein NPV_P10 PF05531.7 CDF90364.1 - 2.1 8.6 9.4 1.9 8.7 0.8 3.9 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Sec23_trunk PF04811.10 CDF90365.1 - 1.3e-75 253.9 0.0 1.8e-75 253.4 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 CDF90365.1 - 4.6e-35 119.1 0.1 1.1e-34 117.9 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.7 CDF90365.1 - 7.1e-29 100.1 0.2 1.6e-28 99.0 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.10 CDF90365.1 - 5.5e-14 51.4 8.9 1e-13 50.6 6.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.17 CDF90365.1 - 5.6e-11 41.9 0.0 1.2e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat zf-MIZ PF02891.15 CDF90365.1 - 0.064 12.7 1.9 0.13 11.7 1.3 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-RanBP PF00641.13 CDF90365.1 - 0.084 11.9 0.7 0.19 10.8 0.5 1.6 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others PIG-U PF06728.8 CDF90366.1 - 6.7e-96 321.4 38.7 8.1e-96 321.1 26.8 1.1 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U LSM PF01423.17 CDF90367.1 - 1.1e-17 63.3 0.1 1.4e-17 62.9 0.1 1.1 1 0 0 1 1 1 1 LSM domain Glycos_transf_2 PF00535.21 CDF90368.1 - 7.5e-29 100.5 0.0 1e-28 100.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.4 CDF90368.1 - 3.8e-08 32.7 0.0 5.9e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_3 PF13641.1 CDF90368.1 - 2.7e-07 30.6 0.0 3.2e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 hDGE_amylase PF14701.1 CDF90369.1 - 3.2e-169 563.2 0.1 5e-169 562.6 0.1 1.3 1 0 0 1 1 1 1 glucanotransferase domain of human glycogen debranching enzyme GDE_C PF06202.9 CDF90369.1 - 4.1e-119 397.6 0.0 8.8e-119 396.5 0.0 1.6 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.1 CDF90369.1 - 2.6e-70 236.5 0.0 4.6e-70 235.7 0.0 1.4 1 0 0 1 1 1 1 central domain of human glycogen debranching enzyme hGDE_N PF14699.1 CDF90369.1 - 1.6e-22 79.1 0.0 3.5e-22 78.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.19 CDF90369.1 - 2e-08 34.0 0.2 0.00016 21.1 0.1 2.4 2 0 0 2 2 2 2 Alpha amylase, catalytic domain ATG13 PF10033.4 CDF90370.1 - 3.3e-65 219.7 0.2 5.8e-65 218.9 0.1 1.4 1 0 0 1 1 1 1 Autophagy-related protein 13 zf-C2H2 PF00096.21 CDF90371.1 - 3.3e-28 96.2 68.7 0.00046 20.3 3.9 9.3 9 0 0 9 9 9 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CDF90371.1 - 2.4e-23 80.6 62.6 0.0044 17.2 3.3 9.4 9 0 0 9 9 9 9 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CDF90371.1 - 7.9e-14 51.1 76.6 4.7e-05 23.4 2.4 10.1 9 1 1 10 10 10 7 Zinc-finger double domain zf-C2H2_jaz PF12171.3 CDF90371.1 - 1.3e-06 28.3 31.3 0.39 10.9 0.2 8.5 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 CDF90371.1 - 4.8e-06 26.5 35.1 0.14 12.3 0.1 8.6 9 0 0 9 9 9 5 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.2 CDF90371.1 - 6.3 6.9 38.6 2.1 8.4 0.9 6.2 2 1 3 6 6 6 0 C2H2 type zinc-finger (2 copies) PyrI_C PF02748.10 CDF90371.1 - 6.9 6.1 15.3 0.33 10.4 1.1 4.6 4 2 1 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain RNA_pol_Rpb6 PF01192.17 CDF90372.1 - 3.6e-23 81.0 0.2 5.2e-23 80.5 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 EF-hand_7 PF13499.1 CDF90373.1 - 2.7e-09 37.0 2.6 1.6e-08 34.5 0.5 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 CDF90373.1 - 2.9e-07 29.7 4.9 3e-06 26.6 0.4 3.9 4 1 0 4 4 4 1 EF-hand domain EF-hand_1 PF00036.27 CDF90373.1 - 4e-05 22.6 0.7 4e-05 22.6 0.5 3.8 4 0 0 4 4 4 1 EF hand EF-hand_5 PF13202.1 CDF90373.1 - 7.3e-05 21.9 2.4 7.3e-05 21.9 1.7 2.2 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.1 CDF90373.1 - 0.00072 19.1 7.3 0.089 12.4 0.5 3.6 2 1 2 4 4 4 2 EF-hand domain pair EF-hand_9 PF14658.1 CDF90373.1 - 0.11 12.4 0.0 8.9 6.3 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain RNA_pol_Rpc82 PF05645.8 CDF90375.1 - 4.2e-66 223.1 0.4 8e-66 222.1 0.1 1.6 2 0 0 2 2 2 1 RNA polymerase III subunit RPC82 HTH_9 PF08221.6 CDF90375.1 - 6.7e-20 70.7 4.6 5e-18 64.7 0.2 3.7 4 1 0 4 4 4 2 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.12 CDF90375.1 - 0.0038 16.6 1.3 0.18 11.3 0.0 3.3 3 1 1 4 4 4 1 TFIIE alpha subunit AAA_12 PF13087.1 CDF90376.1 - 1.7e-60 203.8 0.1 3.9e-60 202.6 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 CDF90376.1 - 7.1e-54 182.8 0.2 7.1e-54 182.8 0.2 1.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CDF90376.1 - 7e-14 51.3 0.0 8.8e-13 47.8 0.0 2.5 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 CDF90376.1 - 6.6e-10 38.8 0.0 1.7e-06 27.7 0.0 2.6 1 1 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.13 CDF90376.1 - 1.4e-09 37.8 0.2 0.045 13.2 0.0 3.4 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.16 CDF90376.1 - 5.5e-06 25.8 0.0 2.4e-05 23.7 0.0 2.1 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_22 PF13401.1 CDF90376.1 - 4.4e-05 23.6 0.1 0.0011 19.1 0.1 2.8 1 1 0 1 1 1 1 AAA domain Helicase_RecD PF05127.9 CDF90376.1 - 5.7e-05 22.8 0.0 0.00054 19.6 0.0 2.5 2 1 0 2 2 2 1 Helicase Zot PF05707.7 CDF90376.1 - 5.7e-05 22.6 0.0 0.00015 21.3 0.0 1.7 1 0 0 1 1 1 1 Zonular occludens toxin (Zot) PhoH PF02562.11 CDF90376.1 - 6.4e-05 22.2 0.0 0.0057 15.8 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein ResIII PF04851.10 CDF90376.1 - 0.00039 20.3 0.4 0.003 17.4 0.0 2.6 3 1 0 3 3 2 1 Type III restriction enzyme, res subunit DEAD PF00270.24 CDF90376.1 - 0.0007 19.1 0.1 0.0042 16.5 0.0 2.2 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_16 PF13191.1 CDF90376.1 - 0.00071 19.6 0.1 0.0017 18.3 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.1 CDF90376.1 - 0.00092 19.5 1.8 0.14 12.4 0.2 3.7 3 1 0 3 3 2 1 AAA domain AAA PF00004.24 CDF90376.1 - 0.0024 18.0 1.8 0.021 15.0 0.4 3.0 2 1 1 3 3 2 1 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.4 CDF90376.1 - 0.0029 16.6 0.4 0.016 14.1 0.3 2.2 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.12 CDF90376.1 - 0.003 16.9 0.0 0.0082 15.5 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF853 PF05872.7 CDF90376.1 - 0.0063 14.9 0.0 0.0098 14.2 0.0 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF853) PIF1 PF05970.9 CDF90376.1 - 0.0065 15.4 0.1 1.1 8.1 0.0 2.8 2 1 1 3 3 3 1 PIF1-like helicase TrwB_AAD_bind PF10412.4 CDF90376.1 - 0.0071 15.0 0.0 0.021 13.4 0.0 1.7 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain AAA_14 PF13173.1 CDF90376.1 - 0.0073 16.1 0.0 0.11 12.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.1 CDF90376.1 - 0.016 14.5 0.0 0.052 12.9 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.1 CDF90376.1 - 0.025 15.4 0.3 0.16 12.8 0.2 2.5 1 1 0 1 1 1 0 AAA domain UvrD_C_2 PF13538.1 CDF90376.1 - 0.027 14.5 0.0 0.081 13.0 0.0 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Flavi_DEAD PF07652.9 CDF90376.1 - 0.049 13.3 0.1 0.19 11.4 0.0 2.0 2 0 0 2 2 2 0 Flavivirus DEAD domain RNA_helicase PF00910.17 CDF90376.1 - 0.054 13.6 0.0 0.19 11.9 0.0 2.0 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.1 CDF90376.1 - 0.063 13.1 0.0 0.17 11.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.11 CDF90376.1 - 0.081 12.1 0.0 0.2 10.8 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function, DUF258 WD40 PF00400.27 CDF90377.1 - 3.1e-14 52.2 0.5 1e-05 25.1 0.0 5.3 6 0 0 6 6 6 3 WD domain, G-beta repeat Cytochrom_D1 PF02239.11 CDF90377.1 - 0.022 13.0 0.0 0.79 7.9 0.0 2.7 2 1 0 3 3 3 0 Cytochrome D1 heme domain DUF1748 PF08520.5 CDF90378.1 - 1.7e-19 69.1 0.4 2.4e-19 68.7 0.2 1.2 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) Apc15p PF05841.6 CDF90379.1 - 8e-22 78.2 8.4 8e-22 78.2 5.8 2.4 1 1 1 2 2 2 1 Apc15p protein DUF3886 PF13025.1 CDF90379.1 - 0.022 14.7 0.4 0.022 14.7 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3886) DUF3578 PF12102.3 CDF90379.1 - 0.12 11.9 0.6 0.4 10.2 0.0 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3578) DSPc PF00782.15 CDF90380.1 - 3.3e-26 91.4 0.5 2.7e-25 88.4 0.3 2.2 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 CDF90380.1 - 0.00069 19.0 0.0 0.0012 18.2 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Yippee-Mis18 PF03226.9 CDF90380.1 - 0.011 15.7 0.7 0.053 13.5 0.5 2.1 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly PTPlike_phytase PF14566.1 CDF90380.1 - 0.029 14.3 0.0 0.067 13.2 0.0 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate DUF35_N PF12172.3 CDF90380.1 - 7.5 6.5 7.3 3.7 7.5 0.1 3.2 2 1 1 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) PPTA PF01239.17 CDF90381.1 - 1.6e-36 122.1 15.4 1.4e-08 33.7 0.1 5.3 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat ACPS PF01648.15 CDF90381.1 - 0.1 12.4 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 4'-phosphopantetheinyl transferase superfamily TPR_2 PF07719.12 CDF90381.1 - 0.12 12.3 0.9 2.7 8.1 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Ank PF00023.25 CDF90382.1 - 9.4e-13 47.2 0.0 5.4e-06 25.9 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat TIG PF01833.19 CDF90382.1 - 1.2e-10 41.2 1.8 2.8e-10 40.0 1.2 1.7 1 0 0 1 1 1 1 IPT/TIG domain Ank_2 PF12796.2 CDF90382.1 - 3e-10 40.3 0.0 5.7e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.1 CDF90382.1 - 2e-07 30.9 0.0 7.4e-06 26.0 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.1 CDF90382.1 - 2.2e-07 31.1 0.1 1.6e-06 28.4 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDF90382.1 - 1.2e-05 25.0 0.0 0.079 13.2 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat WD40 PF00400.27 CDF90383.1 - 1e-30 104.4 3.4 3.5e-08 33.0 0.3 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat Nucleoporin_N PF08801.6 CDF90383.1 - 2.4e-05 23.2 3.4 1.6 7.4 0.0 4.1 1 1 2 4 4 4 4 Nup133 N terminal like Nup160 PF11715.3 CDF90383.1 - 0.0001 20.6 0.5 0.0062 14.7 0.1 2.7 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Tox-PL PF15644.1 CDF90383.1 - 0.01 16.5 0.4 1.2 9.9 0.0 3.5 3 1 0 3 3 3 1 Papain fold toxin 1 CRT10 PF08728.5 CDF90383.1 - 0.023 12.7 0.0 0.052 11.5 0.0 1.6 1 1 0 1 1 1 0 CRT10 AlaDh_PNT_N PF05222.10 CDF90384.1 - 1.8e-29 102.4 0.0 2.6e-29 101.9 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.16 CDF90384.1 - 3.2e-16 59.3 0.0 4.6e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TPR_1 PF00515.23 CDF90385.1 - 1.1e-34 116.5 4.4 3.1e-05 23.3 0.0 9.4 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_2 PF07719.12 CDF90385.1 - 1.1e-32 109.2 7.3 0.00056 19.6 0.0 9.8 10 0 0 10 10 9 6 Tetratricopeptide repeat TPR_11 PF13414.1 CDF90385.1 - 5e-31 106.1 7.9 7.5e-11 41.5 0.1 6.9 5 1 2 7 7 7 5 TPR repeat Apc3 PF12895.2 CDF90385.1 - 4.5e-26 90.8 17.0 1e-19 70.4 0.0 5.5 4 2 2 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.1 CDF90385.1 - 1.2e-21 76.8 0.0 3.2e-06 27.6 0.0 6.7 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.1 CDF90385.1 - 2.1e-20 70.8 9.3 0.00021 20.8 0.1 8.3 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_12 PF13424.1 CDF90385.1 - 1.9e-19 69.3 14.2 1.5e-09 37.6 0.0 7.6 4 3 4 8 8 8 7 Tetratricopeptide repeat TPR_19 PF14559.1 CDF90385.1 - 2.1e-19 69.5 3.7 0.00018 21.8 0.0 6.7 6 1 2 8 8 7 4 Tetratricopeptide repeat TPR_14 PF13428.1 CDF90385.1 - 2.2e-18 65.0 3.0 0.0035 17.8 0.0 8.7 5 2 4 9 9 8 2 Tetratricopeptide repeat TPR_7 PF13176.1 CDF90385.1 - 2.7e-16 58.0 14.1 4.6e-05 22.9 0.0 7.1 6 1 1 7 7 6 4 Tetratricopeptide repeat TPR_17 PF13431.1 CDF90385.1 - 3.6e-16 57.9 1.0 0.026 14.7 0.0 7.8 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_10 PF13374.1 CDF90385.1 - 1.8e-12 46.7 0.6 0.076 12.9 0.0 6.6 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_9 PF13371.1 CDF90385.1 - 2.9e-08 33.4 1.9 0.0038 17.0 0.0 3.9 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_15 PF13429.1 CDF90385.1 - 6.4e-08 31.9 4.4 0.0019 17.2 0.4 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.1 CDF90385.1 - 2.6e-06 27.5 13.3 0.76 10.3 0.0 7.6 9 0 0 9 9 7 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 CDF90385.1 - 9.8e-05 22.1 8.7 8.5 6.3 0.3 5.4 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.9 CDF90385.1 - 0.0076 16.5 0.3 4.1 8.1 0.0 3.5 4 0 0 4 4 2 1 Tetratricopeptide repeat TPR_21 PF09976.4 CDF90385.1 - 0.015 15.2 3.9 2.5 8.0 0.1 4.3 3 1 0 3 3 3 0 Tetratricopeptide repeat LIM_bind PF01803.11 CDF90385.1 - 0.049 12.7 0.2 0.12 11.4 0.1 1.6 1 0 0 1 1 1 0 LIM-domain binding protein Foie-gras_1 PF11817.3 CDF90385.1 - 0.063 12.7 0.6 0.17 11.3 0.0 2.0 2 0 0 2 2 2 0 Foie gras liver health family 1 Spc7_N PF15402.1 CDF90385.1 - 0.092 10.7 2.5 0.13 10.2 1.7 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Acetone_carb_G PF08882.6 CDF90385.1 - 0.1 12.6 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Acetone carboxylase gamma subunit TPR_3 PF07720.7 CDF90385.1 - 0.22 11.3 4.6 2.5 7.9 0.0 4.6 6 0 0 6 6 6 0 Tetratricopeptide repeat ADK PF00406.17 CDF90387.1 - 3.3e-47 160.1 0.0 4.5e-47 159.7 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_18 PF13238.1 CDF90387.1 - 2e-11 44.2 0.0 7.6e-11 42.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 CDF90387.1 - 3.5e-08 33.4 0.0 6.2e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CDF90387.1 - 5.8e-07 30.3 0.0 9.9e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.12 CDF90387.1 - 0.00044 19.6 0.5 0.15 11.4 0.0 2.3 2 0 0 2 2 2 2 Thymidylate kinase SRP54 PF00448.17 CDF90387.1 - 0.0017 17.8 0.0 0.0032 16.9 0.0 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain Zeta_toxin PF06414.7 CDF90387.1 - 0.013 14.6 0.0 0.02 14.0 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin adh_short PF00106.20 CDF90388.1 - 1.1e-29 103.5 0.1 1.3e-29 103.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CDF90388.1 - 6.1e-13 49.0 0.3 7.2e-13 48.8 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CDF90388.1 - 7.9e-13 48.4 0.1 1.1e-12 47.9 0.1 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 CDF90388.1 - 3.9e-07 29.7 0.1 6.3e-06 25.8 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.10 CDF90388.1 - 0.0027 16.6 0.2 0.0033 16.3 0.1 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.14 CDF90388.1 - 0.013 14.1 0.1 0.018 13.7 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.1 CDF90388.1 - 0.022 14.7 0.2 0.042 13.8 0.1 1.6 1 1 0 1 1 1 0 NADH(P)-binding tRNA_m1G_MT PF01746.16 CDF90388.1 - 0.11 12.0 0.2 0.2 11.2 0.1 1.4 1 0 0 1 1 1 0 tRNA (Guanine-1)-methyltransferase Pkinase PF00069.20 CDF90389.1 - 0.062 12.4 0.0 0.14 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein kinase domain PhzC-PhzF PF02567.11 CDF90390.1 - 1.4e-65 221.3 0.0 1.5e-65 221.1 0.0 1.0 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein Pro_racemase PF05544.6 CDF90390.1 - 2.2e-05 23.4 0.0 3.9e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Proline racemase Lactamase_B PF00753.22 CDF90390.1 - 0.11 12.1 0.1 1.9 8.1 0.0 2.1 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily MFS_1 PF07690.11 CDF90391.1 - 1e-34 119.8 41.8 1e-34 119.8 29.0 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.19 CDF90391.1 - 5.6e-08 31.7 31.0 4.1e-07 28.9 21.5 2.2 1 1 0 1 1 1 1 Sugar (and other) transporter SpoVAB PF13782.1 CDF90391.1 - 3.5 7.6 13.2 0.16 11.9 1.5 3.0 3 0 0 3 3 3 0 Stage V sporulation protein AB Cys_Met_Meta_PP PF01053.15 CDF90393.1 - 7e-27 93.6 0.0 1.6e-25 89.2 0.0 2.1 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 CDF90393.1 - 0.028 13.3 0.0 0.049 12.5 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II DUF1484 PF07363.6 CDF90393.1 - 0.043 14.1 0.0 0.43 10.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1484) UPF0016 PF01169.14 CDF90395.1 - 1.9e-39 133.6 18.0 2.2e-20 72.5 3.4 2.1 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 LysE PF01810.13 CDF90395.1 - 0.0058 15.9 12.3 0.079 12.2 1.7 3.2 2 1 1 3 3 3 2 LysE type translocator TauE PF01925.14 CDF90395.1 - 0.021 14.2 6.6 0.052 13.0 0.2 2.2 2 0 0 2 2 2 0 Sulfite exporter TauE/SafE DUF3433 PF11915.3 CDF90395.1 - 0.08 13.1 1.2 0.25 11.5 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3433) Cys_Met_Meta_PP PF01053.15 CDF90396.1 - 4.2e-85 285.3 0.0 5e-85 285.1 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 CDF90396.1 - 0.0022 16.8 0.0 0.0032 16.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 CDF90396.1 - 0.079 12.0 0.0 0.25 10.4 0.0 1.7 1 1 0 1 1 1 0 Beta-eliminating lyase AA_permease PF00324.16 CDF90400.1 - 7.7e-48 163.0 33.9 1.3e-47 162.2 23.5 1.3 1 0 0 1 1 1 1 Amino acid permease Pox_MCEL PF03291.11 CDF90401.1 - 1.9e-100 335.9 0.1 3e-100 335.3 0.0 1.3 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_12 PF08242.7 CDF90401.1 - 7.9e-09 35.8 0.0 3e-08 34.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDF90401.1 - 2.7e-08 33.5 0.0 6e-08 32.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDF90401.1 - 1.5e-07 31.7 0.0 3.6e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDF90401.1 - 3.7e-07 30.7 0.0 8.1e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDF90401.1 - 4e-07 30.3 0.0 8.8e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDF90401.1 - 2.7e-06 27.1 0.0 4.4e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 CDF90401.1 - 0.0037 16.3 0.0 0.0073 15.3 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase NNMT_PNMT_TEMT PF01234.12 CDF90401.1 - 0.0073 15.3 0.0 0.025 13.5 0.0 1.8 2 0 0 2 2 2 1 NNMT/PNMT/TEMT family TPMT PF05724.6 CDF90401.1 - 0.1 12.0 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_26 PF13659.1 CDF90401.1 - 0.13 12.3 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DEAD PF00270.24 CDF90402.1 - 2.1e-42 144.4 0.0 5.2e-42 143.2 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF90402.1 - 1.4e-17 63.3 0.0 3.5e-17 62.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 CDF90402.1 - 1.1e-05 24.4 0.0 2.2e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain XFP PF03894.10 CDF90402.1 - 0.41 10.2 2.5 0.22 11.1 0.1 1.7 2 0 0 2 2 2 0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase DNA_methylase PF00145.12 CDF90403.1 - 0.5 9.4 3.8 0.42 9.6 2.1 1.3 1 1 0 1 1 1 0 C-5 cytosine-specific DNA methylase DapB_C PF05173.9 CDF90403.1 - 2.6 7.8 6.0 0.91 9.2 2.3 1.6 1 1 1 2 2 2 0 Dihydrodipicolinate reductase, C-terminus DUF1843 PF08898.5 CDF90404.1 - 2.6 8.1 7.8 2.3 8.3 4.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) Arrestin_C PF02752.17 CDF90405.1 - 4.2e-14 52.8 0.0 1.7e-13 50.8 0.0 2.1 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 CDF90405.1 - 3.6e-08 33.3 0.0 9.5e-05 22.2 0.0 2.5 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Exo70 PF03081.10 CDF90406.1 - 2.1e-87 293.3 3.0 4.2e-86 289.0 0.1 2.2 2 0 0 2 2 2 2 Exo70 exocyst complex subunit Sec5 PF15469.1 CDF90406.1 - 0.0085 15.8 5.6 0.095 12.4 0.0 3.4 4 0 0 4 4 4 2 Exocyst complex component Sec5 DUF725 PF05267.7 CDF90406.1 - 0.41 10.5 2.1 0.75 9.7 0.2 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF725) RNA_lig_T4_1 PF09511.5 CDF90407.1 - 1.5e-79 266.5 0.1 3.9e-79 265.2 0.1 1.7 1 0 0 1 1 1 1 RNA ligase tRNA_lig_kinase PF08303.6 CDF90407.1 - 3.8e-72 241.6 0.0 1.1e-71 240.1 0.0 1.8 1 0 0 1 1 1 1 tRNA ligase kinase domain tRNA_lig_CPD PF08302.6 CDF90407.1 - 1.4e-61 207.9 3.1 2.4e-61 207.2 2.2 1.3 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain OTCace PF00185.19 CDF90408.1 - 4.8e-43 146.7 0.4 8.5e-43 145.9 0.3 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.16 CDF90408.1 - 9.4e-40 135.5 0.7 1.7e-39 134.6 0.1 1.7 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain NTR2 PF15458.1 CDF90409.1 - 8.6e-18 64.4 20.6 1.6e-17 63.6 14.3 1.5 1 1 0 1 1 1 1 Nineteen complex-related protein 2 GED PF02212.13 CDF90409.1 - 0.72 9.7 5.5 0.34 10.8 1.4 2.1 1 1 1 2 2 2 0 Dynamin GTPase effector domain Zn_clus PF00172.13 CDF90410.1 - 1.3e-11 44.2 11.4 2.2e-11 43.4 7.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BRCT PF00533.21 CDF90411.1 - 1.9e-17 63.1 0.9 0.00019 21.5 0.0 5.0 4 1 0 4 4 4 4 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.2 CDF90411.1 - 2.1e-11 43.5 0.1 1.9e-05 24.4 0.0 4.3 4 0 0 4 4 4 3 twin BRCT domain GWT1 PF06423.7 CDF90412.1 - 1.1e-45 155.0 2.7 1.1e-45 155.0 1.9 2.9 3 1 0 3 3 3 1 GWT1 Na_H_Exchanger PF00999.16 CDF90414.1 - 8.6e-63 212.1 30.3 1.3e-62 211.5 21.0 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Pkinase PF00069.20 CDF90415.1 - 9.6e-67 224.8 0.0 4.9e-66 222.5 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF90415.1 - 6.3e-46 156.5 0.0 1.3e-45 155.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF90415.1 - 7e-13 48.1 0.0 1.8e-09 36.9 0.0 2.3 2 0 0 2 2 2 2 Kinase-like SAM_2 PF07647.12 CDF90415.1 - 0.039 13.8 0.1 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_PNT PF02198.11 CDF90415.1 - 0.055 13.2 0.1 0.15 11.8 0.1 1.7 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain APH PF01636.18 CDF90415.1 - 0.4 10.3 0.0 0.69 9.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ribosomal_L21p PF00829.16 CDF90416.1 - 6.9e-05 22.9 0.0 8.7e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein PTPLA PF04387.9 CDF90417.1 - 1.9e-43 147.7 7.4 2.7e-43 147.2 5.1 1.2 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA SAPS PF04499.10 CDF90418.1 - 2.1e-176 587.2 2.3 2.1e-176 587.2 1.6 2.9 3 1 0 3 3 3 1 SIT4 phosphatase-associated protein ChAPs PF09295.5 CDF90420.1 - 7.3e-47 159.9 0.5 1.8e-37 129.0 0.1 2.1 2 0 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_2 PF07719.12 CDF90420.1 - 2e-05 24.1 0.1 0.0077 16.0 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.23 CDF90420.1 - 3.7e-05 23.1 0.2 9.3e-05 21.8 0.1 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.1 CDF90420.1 - 0.00016 21.2 0.1 0.0016 18.0 0.0 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.1 CDF90420.1 - 0.00072 19.1 0.0 0.0061 16.1 0.0 2.2 2 0 0 2 2 2 1 TPR repeat TPR_19 PF14559.1 CDF90420.1 - 0.0012 19.0 0.0 0.006 16.8 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 CDF90420.1 - 0.0053 16.8 0.0 0.016 15.3 0.0 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.1 CDF90420.1 - 0.0062 16.3 0.1 0.18 11.7 0.0 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.1 CDF90420.1 - 0.008 16.8 0.0 0.023 15.3 0.0 1.7 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_12 PF13424.1 CDF90420.1 - 0.011 15.6 0.0 0.11 12.3 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.1 CDF90420.1 - 0.05 13.8 0.0 0.23 11.7 0.0 2.3 1 0 0 1 1 1 0 Tetratricopeptide repeat PI3_PI4_kinase PF00454.22 CDF90421.1 - 1.3e-56 191.7 0.1 2e-56 191.0 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase GCS PF03074.11 CDF90422.1 - 7.8e-146 485.8 0.0 1.1e-145 485.4 0.0 1.2 1 0 0 1 1 1 1 Glutamate-cysteine ligase IMD PF08397.6 CDF90422.1 - 0.12 11.7 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 IRSp53/MIM homology domain GTP_EFTU PF00009.22 CDF90423.1 - 6.4e-57 192.0 0.0 1.1e-56 191.3 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.1 CDF90423.1 - 3e-25 87.8 0.0 7.3e-25 86.6 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.19 CDF90423.1 - 3.1e-18 65.4 0.1 2.3e-16 59.4 0.1 2.5 1 1 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 CDF90423.1 - 3.3e-06 27.1 0.1 8.2e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 CDF90423.1 - 0.0011 18.8 0.6 0.0023 17.8 0.1 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.5 CDF90423.1 - 0.058 12.6 0.0 0.12 11.6 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Miro PF08477.8 CDF90423.1 - 0.1 13.0 0.3 0.54 10.7 0.0 2.3 2 0 0 2 2 2 0 Miro-like protein IF-2B PF01008.12 CDF90424.1 - 3.4e-68 229.6 0.0 3.8e-68 229.5 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family DUF3343 PF11823.3 CDF90424.1 - 0.11 11.7 0.0 0.53 9.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3343) Sin_N PF04801.8 CDF90425.1 - 2.6e-15 56.1 0.1 3.7e-15 55.7 0.1 1.2 1 0 0 1 1 1 1 Sin-like protein conserved region DEAD PF00270.24 CDF90426.1 - 1.5e-37 128.6 0.0 2.6e-37 127.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF90426.1 - 6.7e-20 70.7 0.0 1.6e-19 69.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 CDF90426.1 - 5.4e-18 64.2 0.1 1.1e-17 63.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.10 CDF90426.1 - 0.00014 21.7 0.9 0.00054 19.8 0.0 2.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Zn_clus PF00172.13 CDF90427.1 - 1.5e-05 24.7 12.4 3.3e-05 23.7 8.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.19 CDF90427.1 - 6.6e-05 22.6 0.0 0.00018 21.2 0.0 1.7 1 0 0 1 1 1 1 PAS fold zf-C2HC5 PF06221.8 CDF90428.1 - 1e-18 66.8 5.3 1.8e-18 65.9 3.7 1.4 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type PS_Dcarbxylase PF02666.10 CDF90429.1 - 1.2e-53 181.3 0.0 2.1e-53 180.6 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.25 CDF90429.1 - 6e-13 48.4 0.7 2.9e-09 36.6 0.1 2.5 2 0 0 2 2 2 2 C2 domain DNA_pol_E_B PF04042.11 CDF90430.1 - 9.2e-48 162.2 0.4 1.6e-46 158.2 0.0 2.1 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B PDZ_assoc PF10600.4 CDF90430.1 - 0.029 14.6 0.0 0.064 13.5 0.0 1.6 1 0 0 1 1 1 0 PDZ-associated domain of NMDA receptors DUF4238 PF14022.1 CDF90430.1 - 0.11 11.7 0.2 0.24 10.6 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4238) tRNA-synt_1g PF09334.6 CDF90431.1 - 2.4e-110 368.8 3.3 7.3e-110 367.2 2.3 1.7 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 CDF90431.1 - 1.4e-25 89.3 0.6 9.5e-10 37.1 0.0 4.1 1 1 2 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.14 CDF90431.1 - 3.3e-06 26.4 0.0 0.0073 15.4 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.8 CDF90431.1 - 0.0013 18.5 0.0 0.0028 17.4 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA Hira PF07569.6 CDF90431.1 - 0.24 10.5 1.8 1.1 8.4 0.1 2.2 2 0 0 2 2 2 0 TUP1-like enhancer of split Yip1 PF04893.12 CDF90432.1 - 1.2e-12 47.6 12.3 2e-12 46.9 8.6 1.4 1 0 0 1 1 1 1 Yip1 domain HAD PF12710.2 CDF90433.1 - 1.2e-14 54.9 0.0 2.8e-14 53.7 0.0 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 CDF90433.1 - 8.4e-13 49.2 0.1 2.8e-11 44.2 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 CDF90433.1 - 2.4e-08 33.9 0.0 6.3e-07 29.2 0.0 2.5 2 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 CDF90433.1 - 7.2e-05 23.0 0.1 0.0027 17.9 0.1 2.7 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.7 CDF90433.1 - 0.0005 19.3 0.1 0.0027 16.9 0.0 1.9 1 1 0 1 1 1 1 Putative Phosphatase S6PP PF05116.8 CDF90433.1 - 0.0048 16.2 0.2 0.05 12.8 0.0 2.4 3 0 0 3 3 3 1 Sucrose-6F-phosphate phosphohydrolase DUF2608 PF11019.3 CDF90433.1 - 0.015 14.3 0.1 0.024 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2608) DUF705 PF05152.7 CDF90433.1 - 0.059 12.3 0.2 0.086 11.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF705) Acid_PPase PF12689.2 CDF90433.1 - 0.12 12.0 0.0 0.66 9.5 0.0 2.1 1 1 0 1 1 1 0 Acid Phosphatase Thioredoxin PF00085.15 CDF90434.1 - 1.2e-30 105.2 0.7 1.3e-30 105.1 0.5 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 CDF90434.1 - 6.2e-08 32.8 0.5 1.2e-06 28.6 0.4 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 CDF90434.1 - 3.8e-07 30.1 0.2 9.9e-07 28.8 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.1 CDF90434.1 - 1.4e-06 27.8 0.1 1.6e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.5 CDF90434.1 - 2.5e-05 23.8 0.5 7.3e-05 22.3 0.3 1.6 1 1 1 2 2 2 1 Redoxin AhpC-TSA PF00578.16 CDF90434.1 - 6.3e-05 22.6 0.1 7.3e-05 22.4 0.1 1.1 1 0 0 1 1 1 1 AhpC/TSA family DIM1 PF02966.11 CDF90434.1 - 0.00095 18.6 0.0 0.0012 18.3 0.0 1.1 1 0 0 1 1 1 1 Mitosis protein DIM1 DUF2847 PF11009.3 CDF90434.1 - 0.012 15.2 0.0 0.027 14.0 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2847) Thioredoxin_4 PF13462.1 CDF90434.1 - 0.015 15.3 0.7 0.58 10.1 0.1 2.0 1 1 1 2 2 2 0 Thioredoxin TraF PF13728.1 CDF90434.1 - 0.017 14.6 0.1 0.023 14.1 0.1 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_7 PF13899.1 CDF90434.1 - 0.05 13.6 0.4 0.15 12.0 0.3 1.9 1 1 0 1 1 1 0 Thioredoxin-like HEAT_2 PF13646.1 CDF90435.1 - 3.8e-06 27.0 0.1 0.24 11.6 0.0 3.8 4 1 0 4 4 4 2 HEAT repeats HEAT PF02985.17 CDF90435.1 - 2.5e-05 23.9 0.5 2.9 8.2 0.0 6.5 7 0 0 7 7 7 1 HEAT repeat ATG16 PF08614.6 CDF90435.1 - 0.00018 21.4 11.9 0.00018 21.4 8.2 3.4 3 1 0 3 3 3 1 Autophagy protein 16 (ATG16) DUF972 PF06156.8 CDF90435.1 - 1.9 8.8 16.0 0.11 12.8 3.8 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF972) MMR_HSR1_C PF08438.5 CDF90437.1 - 1.9e-31 108.4 0.0 3e-31 107.8 0.0 1.3 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.18 CDF90437.1 - 1.1e-17 64.1 0.0 2.2e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 CDF90437.1 - 2.3e-06 26.9 0.1 2.2e-05 23.7 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 CDF90437.1 - 0.0029 17.0 0.0 2 7.8 0.0 2.4 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AAA_10 PF12846.2 CDF90437.1 - 0.028 13.8 0.0 0.063 12.7 0.0 1.6 2 0 0 2 2 2 0 AAA-like domain Dynamin_N PF00350.18 CDF90437.1 - 0.031 14.1 0.5 0.1 12.4 0.1 2.0 3 0 0 3 3 3 0 Dynamin family ArgK PF03308.11 CDF90437.1 - 0.081 11.6 0.2 0.29 9.8 0.0 2.0 2 0 0 2 2 2 0 ArgK protein ATP_bind_1 PF03029.12 CDF90437.1 - 0.11 12.0 0.1 12 5.3 0.0 2.6 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein ABC_tran PF00005.22 CDF90437.1 - 0.12 12.7 0.0 0.56 10.5 0.0 2.0 2 0 0 2 2 2 0 ABC transporter AAA_17 PF13207.1 CDF90437.1 - 0.8 10.5 3.7 1 10.2 0.7 2.6 2 2 0 2 2 2 0 AAA domain zf-ZPR1 PF03367.8 CDF90438.1 - 3.1e-119 393.8 4.7 5.9e-59 197.8 0.1 2.3 2 0 0 2 2 2 2 ZPR1 zinc-finger domain Lar_restr_allev PF14354.1 CDF90438.1 - 0.02 15.1 2.5 2.3 8.6 0.4 3.3 3 0 0 3 3 3 0 Restriction alleviation protein Lar HypA PF01155.14 CDF90438.1 - 0.021 14.5 3.0 2.4 7.8 0.4 2.6 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family UPF0547 PF10571.4 CDF90438.1 - 0.082 12.6 6.8 1.3 8.8 0.1 3.2 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 Cytochrom_C_2 PF01322.15 CDF90438.1 - 0.75 10.3 3.2 2.5 8.6 0.2 2.8 3 0 0 3 3 3 0 Cytochrome C' DUF3716 PF12511.3 CDF90438.1 - 0.94 9.1 4.5 1.9 8.1 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3716) Ribosomal_L32p PF01783.18 CDF90438.1 - 1.7 8.8 3.9 1.2 9.3 0.1 2.6 3 0 0 3 3 3 0 Ribosomal L32p protein family zinc-ribbons_6 PF07191.7 CDF90438.1 - 2.9 7.7 6.6 0.49 10.2 0.7 2.5 3 0 0 3 3 3 0 zinc-ribbons OrfB_Zn_ribbon PF07282.6 CDF90438.1 - 5.4 6.7 6.3 28 4.4 0.0 3.3 2 1 1 3 3 3 0 Putative transposase DNA-binding domain AATase PF07247.7 CDF90439.1 - 1e-65 222.1 5.2 1.3e-65 221.8 3.6 1.0 1 0 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.15 CDF90439.1 - 2.5e-05 23.3 1.0 0.0037 16.1 0.2 2.2 2 0 0 2 2 2 2 Condensation domain Ferric_reduct PF01794.14 CDF90440.1 - 9.2e-20 70.9 9.0 2.5e-19 69.5 6.2 1.8 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 CDF90440.1 - 0.012 15.4 0.0 0.029 14.2 0.0 1.5 1 0 0 1 1 1 0 FAD-binding domain DUF2244 PF10003.4 CDF90440.1 - 0.033 13.5 0.3 0.21 10.9 0.1 2.4 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) Ribosomal_S2 PF00318.15 CDF90441.1 - 5.4e-39 133.6 0.0 4e-21 75.2 0.0 2.3 1 1 1 2 2 2 2 Ribosomal protein S2 Adaptin_N PF01602.15 CDF90442.1 - 2.5e-102 342.8 8.4 4.4e-102 342.1 5.8 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.1 CDF90442.1 - 9.9e-60 199.9 0.0 2.2e-59 198.8 0.0 1.6 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.7 CDF90442.1 - 1.6e-52 176.8 0.2 1.6e-52 176.8 0.1 2.0 2 0 0 2 2 2 1 Coatomer beta C-terminal region HEAT_2 PF13646.1 CDF90442.1 - 3.1e-07 30.5 3.2 0.0024 18.1 0.0 4.5 2 1 1 4 4 4 2 HEAT repeats Cnd1 PF12717.2 CDF90442.1 - 0.00043 20.1 7.7 1 9.1 0.0 4.9 3 2 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 CDF90442.1 - 0.011 15.7 0.7 13 6.2 0.0 4.6 4 1 1 5 5 5 0 HEAT repeat Xpo1 PF08389.7 CDF90442.1 - 0.018 14.9 0.8 0.068 13.0 0.5 2.1 1 0 0 1 1 1 0 Exportin 1-like protein HEAT_EZ PF13513.1 CDF90442.1 - 0.97 10.0 3.2 44 4.7 0.0 5.3 7 2 2 9 9 9 0 HEAT-like repeat Ribosomal_L7Ae PF01248.21 CDF90445.1 - 1.2e-27 95.2 0.2 2.1e-27 94.4 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.6 CDF90445.1 - 0.00032 20.5 0.0 0.00051 19.9 0.0 1.3 1 0 0 1 1 1 1 RNase P subunit Pop3 Tegument_dsDNA PF12818.2 CDF90445.1 - 0.088 11.6 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 dsDNA viral tegument protein DUF3692 PF12469.3 CDF90445.1 - 0.53 10.5 3.3 3.1 8.0 2.3 2.0 1 1 0 1 1 1 0 CRISPR-associated protein RRM_5 PF13893.1 CDF90446.1 - 8.7e-05 22.2 0.1 0.00018 21.2 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CDF90446.1 - 0.0015 18.1 0.1 0.003 17.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAA_hydrolase_N PF09298.6 CDF90446.1 - 0.13 12.2 0.2 0.26 11.3 0.1 1.5 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal TPR_11 PF13414.1 CDF90447.1 - 6e-23 80.2 11.0 1.3e-10 40.7 0.1 4.2 2 2 2 4 4 4 4 TPR repeat TPR_1 PF00515.23 CDF90447.1 - 1.2e-18 65.8 2.8 3.7e-06 26.3 0.0 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.12 CDF90447.1 - 1.2e-17 62.3 3.9 0.00027 20.6 0.0 5.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.1 CDF90447.1 - 5.3e-15 54.5 0.8 0.0017 18.8 0.0 5.3 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.1 CDF90447.1 - 1.9e-13 49.4 0.5 0.034 14.3 0.0 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.1 CDF90447.1 - 4.9e-12 46.1 1.6 4.2e-05 24.1 0.0 3.6 2 2 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 CDF90447.1 - 7.9e-12 45.3 2.6 0.011 16.0 0.2 4.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_20 PF14561.1 CDF90447.1 - 2.5e-08 33.9 1.4 0.015 15.4 0.0 4.6 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.1 CDF90447.1 - 1.2e-06 28.3 6.7 0.0077 16.1 0.1 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 CDF90447.1 - 2.4e-06 26.9 1.3 1.7 8.6 0.0 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.1 CDF90447.1 - 1.3e-05 24.9 1.7 0.0092 15.8 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat Apc3 PF12895.2 CDF90447.1 - 3.9e-05 23.6 1.7 0.021 14.9 0.1 2.8 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.1 CDF90447.1 - 0.0012 17.9 0.5 0.15 11.1 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 CDF90447.1 - 0.0049 16.5 0.8 0.99 9.3 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.1 CDF90447.1 - 0.0063 16.9 1.9 99 3.7 0.0 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat Glyco_transf_34 PF05637.7 CDF90448.1 - 3.6e-74 249.2 0.7 4.4e-74 248.9 0.5 1.1 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.9 CDF90448.1 - 0.00046 19.5 0.1 0.27 10.5 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF273 ARID PF01388.16 CDF90449.1 - 5.9e-21 74.1 0.2 5.9e-21 74.1 0.1 3.5 3 0 0 3 3 3 1 ARID/BRIGHT DNA binding domain Med15 PF09606.5 CDF90449.1 - 4.9 5.2 145.9 0.31 9.1 54.7 2.3 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal ERCC4 PF02732.10 CDF90450.1 - 1.6e-24 86.2 0.0 6.4e-24 84.3 0.0 2.1 2 0 0 2 2 2 1 ERCC4 domain MTHFR PF02219.12 CDF90451.1 - 1.2e-107 359.3 0.0 1.7e-107 358.8 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Sybindin PF04099.7 CDF90453.1 - 8e-35 119.6 4.7 2.2e-21 76.0 1.5 3.0 2 1 0 2 2 2 2 Sybindin-like family Sedlin_N PF04628.8 CDF90453.1 - 1.2e-09 38.0 1.0 4.9e-09 36.1 0.7 1.9 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region zf-C2H2 PF00096.21 CDF90454.1 - 4.6e-08 32.9 14.4 0.00018 21.6 0.9 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CDF90454.1 - 6.7e-08 32.3 13.4 0.0015 18.7 2.4 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CDF90454.1 - 6e-07 29.4 17.3 4.1e-05 23.6 2.6 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_6 PF13912.1 CDF90454.1 - 0.12 12.2 5.2 1.3 9.0 0.2 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CDF90454.1 - 1.7 8.8 6.3 27 5.0 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.7 CDF90454.1 - 2.2 8.4 5.3 11 6.2 3.6 2.2 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.1 CDF90454.1 - 2.3 8.6 7.1 0.54 10.6 0.6 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain F-box PF00646.28 CDF90455.1 - 8.1e-06 25.3 1.4 2.7e-05 23.7 1.0 2.0 1 0 0 1 1 1 1 F-box domain Globin PF00042.17 CDF90455.1 - 0.078 13.3 0.1 0.73 10.2 0.0 2.3 2 0 0 2 2 2 0 Globin F-box-like PF12937.2 CDF90455.1 - 0.14 11.9 4.8 0.32 10.7 2.2 2.4 2 0 0 2 2 2 0 F-box-like P21-Arc PF04062.9 CDF90457.1 - 1.8e-74 249.2 0.2 2e-74 249.1 0.1 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit CNH PF00780.17 CDF90458.1 - 1.5e-74 250.8 0.8 2e-74 250.4 0.1 1.6 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.1 CDF90458.1 - 7.8e-36 122.9 0.0 7.8e-36 122.9 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain RhoGEF PF00621.15 CDF90458.1 - 3.2e-31 108.5 0.3 9.5e-31 107.0 0.0 2.0 2 0 0 2 2 2 1 RhoGEF domain DEP PF00610.16 CDF90458.1 - 9.4e-12 44.5 0.0 2.7e-11 43.0 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) ELO PF01151.13 CDF90459.1 - 3.8e-56 190.1 27.0 4.6e-56 189.9 18.7 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family OAD_gamma PF04277.8 CDF90459.1 - 0.38 11.1 0.0 0.38 11.1 0.0 2.3 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain zf-C2H2_6 PF13912.1 CDF90460.1 - 3.1e-05 23.7 8.0 0.0016 18.3 0.1 4.0 3 1 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.21 CDF90460.1 - 0.00051 20.2 1.9 0.00051 20.2 1.3 4.8 4 1 0 4 4 4 1 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.3 CDF90460.1 - 0.0013 18.8 1.7 0.05 13.7 0.0 3.3 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.1 CDF90460.1 - 0.0016 18.6 1.8 0.0016 18.6 1.3 4.7 5 0 0 5 5 4 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CDF90460.1 - 0.0047 17.1 2.9 0.0047 17.1 2.0 5.1 4 1 1 5 5 5 1 Zinc-finger double domain zf-RING_2 PF13639.1 CDF90460.1 - 0.11 12.3 1.9 9.3 6.1 0.0 3.2 3 0 0 3 3 3 0 Ring finger domain Rad50_zn_hook PF04423.9 CDF90460.1 - 0.11 12.0 0.3 0.11 12.0 0.2 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-Di19 PF05605.7 CDF90460.1 - 0.11 12.6 8.9 0.043 13.9 2.6 2.9 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Prok-RING_1 PF14446.1 CDF90460.1 - 0.35 10.6 4.2 7 6.4 0.0 3.1 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-RING_5 PF14634.1 CDF90460.1 - 0.99 9.1 6.2 14 5.4 0.1 3.3 3 0 0 3 3 3 0 zinc-RING finger domain NADH-G_4Fe-4S_3 PF10588.4 CDF90460.1 - 1 8.6 4.0 1 8.6 0.3 2.2 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region zf-RING_3 PF14369.1 CDF90460.1 - 1.7 8.7 5.4 2.4 8.2 0.2 3.1 3 0 0 3 3 3 0 zinc-finger zf-ISL3 PF14690.1 CDF90460.1 - 7.1 6.7 9.4 2.1 8.4 0.8 3.0 3 0 0 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 FA_desaturase PF00487.19 CDF90461.1 - 2.7e-23 82.7 22.0 4.2e-23 82.1 15.3 1.2 1 0 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.3 CDF90461.1 - 0.02 14.9 0.0 0.033 14.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3474) KRE9 PF05390.6 CDF90462.1 - 4.4e-38 129.9 3.5 9.1e-38 128.9 2.4 1.5 1 0 0 1 1 1 1 Yeast cell wall synthesis protein KRE9/KNH1 GPI-anchored PF10342.4 CDF90462.1 - 1.5e-08 34.9 0.4 4.2e-08 33.5 0.1 1.9 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family La PF05383.12 CDF90463.1 - 5e-23 80.6 0.0 1.5e-22 79.1 0.0 1.9 1 0 0 1 1 1 1 La domain RRM_1 PF00076.17 CDF90463.1 - 2.8e-05 23.6 0.1 8.3e-05 22.1 0.1 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF90463.1 - 0.002 18.0 0.1 0.0036 17.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) dNK PF01712.14 CDF90464.1 - 0.041 13.8 0.1 0.06 13.2 0.1 1.2 1 0 0 1 1 1 0 Deoxynucleoside kinase AAA_25 PF13481.1 CDF90464.1 - 0.064 12.6 0.0 0.08 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain Acyltransferase PF01553.16 CDF90465.1 - 2.6e-32 111.0 0.0 3.9e-32 110.4 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase FBPase PF00316.15 CDF90466.1 - 9.2e-129 428.9 0.0 1.1e-128 428.7 0.0 1.0 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase Inositol_P PF00459.20 CDF90466.1 - 0.085 12.1 0.0 0.16 11.2 0.0 1.4 2 0 0 2 2 2 0 Inositol monophosphatase family TCP PF03634.8 CDF90467.1 - 0.25 11.7 6.8 0.36 11.1 4.7 1.3 1 0 0 1 1 1 0 TCP family transcription factor EPL1 PF10513.4 CDF90467.1 - 0.34 11.1 6.4 0.44 10.7 4.4 1.2 1 0 0 1 1 1 0 Enhancer of polycomb-like ORC6 PF05460.8 CDF90467.1 - 0.78 8.7 11.5 0.87 8.6 8.0 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Ndc1_Nup PF09531.5 CDF90467.1 - 5.5 5.2 9.0 6 5.1 6.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PilX PF13681.1 CDF90467.1 - 6 7.4 9.0 2.2 8.8 4.0 2.0 2 1 0 2 2 2 0 Type IV pilus assembly protein PilX C-term MFS_1 PF07690.11 CDF90468.1 - 2.4e-10 39.6 30.7 3.8e-10 39.0 21.3 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily SecY PF00344.15 CDF90469.1 - 1.2e-90 303.9 14.8 1.5e-90 303.6 10.3 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.4 CDF90469.1 - 3.3e-18 64.8 2.4 5.7e-18 64.1 0.1 2.8 2 0 0 2 2 2 1 Plug domain of Sec61p Glyco_hydro_85 PF03644.8 CDF90470.1 - 1.8e-64 217.8 4.5 2.4e-64 217.4 3.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 Erv26 PF04148.8 CDF90471.1 - 2.5e-81 272.0 1.2 2.8e-81 271.9 0.8 1.0 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 Cyto_ox_2 PF02322.10 CDF90471.1 - 0.032 13.3 3.3 0.043 13.0 2.3 1.3 1 1 0 1 1 1 0 Cytochrome oxidase subunit II 6PGD PF00393.14 CDF90472.1 - 9e-134 445.2 0.0 1.2e-133 444.8 0.0 1.2 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.10 CDF90472.1 - 5.5e-54 182.3 0.0 8.3e-54 181.8 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 CDF90472.1 - 0.042 13.9 0.0 0.35 10.9 0.0 2.4 3 0 0 3 3 3 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Mito_carr PF00153.22 CDF90474.1 - 2.3e-61 203.5 0.0 1.1e-19 69.9 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein XPG_N PF00752.12 CDF90476.1 - 7e-35 119.3 0.0 1.7e-34 118.1 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.13 CDF90476.1 - 3.3e-25 87.9 0.0 1.2e-24 86.1 0.0 2.1 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.2 CDF90476.1 - 1.1e-05 25.1 0.0 6.1e-05 22.6 0.0 2.2 1 1 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.15 CDF90476.1 - 0.025 14.8 0.0 0.09 13.0 0.0 1.9 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold DUF3785 PF12653.2 CDF90476.1 - 0.036 13.9 3.5 0.85 9.4 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3785) Phospholip_A2_3 PF09056.6 CDF90476.1 - 0.3 11.2 2.8 0.34 11.1 0.1 2.2 2 0 0 2 2 2 0 Prokaryotic phospholipase A2 Raptor_N PF14538.1 CDF90477.1 - 3.5e-65 218.5 0.0 3.5e-65 218.5 0.0 2.5 2 0 0 2 2 2 1 Raptor N-terminal CASPase like domain HEAT PF02985.17 CDF90477.1 - 3.2e-08 32.9 2.1 0.00074 19.4 0.0 5.6 6 0 0 6 6 6 1 HEAT repeat HEAT_2 PF13646.1 CDF90477.1 - 5.6e-06 26.5 0.0 0.00022 21.4 0.0 2.8 2 0 0 2 2 2 1 HEAT repeats BBS2_Mid PF14783.1 CDF90477.1 - 4.6e-05 23.1 0.1 0.0076 16.0 0.0 2.9 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.27 CDF90477.1 - 0.00019 21.1 6.8 0.86 9.5 0.0 5.7 6 0 0 6 6 6 1 WD domain, G-beta repeat Elong_Iki1 PF10483.4 CDF90478.1 - 4.5e-84 282.1 1.6 5.1e-84 281.9 1.1 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 Gpi16 PF04113.9 CDF90479.1 - 6.9e-189 628.5 0.4 9e-189 628.1 0.3 1.1 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component DUF2711 PF10924.3 CDF90479.1 - 0.066 12.6 0.2 0.89 8.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2711) HEAT_2 PF13646.1 CDF90480.1 - 3.7e-14 52.7 1.5 0.012 15.9 0.0 7.6 3 2 6 9 9 9 6 HEAT repeats HEAT_EZ PF13513.1 CDF90480.1 - 1.7e-10 41.0 0.5 3.8 8.1 0.0 9.1 8 1 1 9 9 9 2 HEAT-like repeat Vac14_Fab1_bd PF12755.2 CDF90480.1 - 8.6e-09 35.6 0.2 0.0087 16.4 0.0 5.6 4 2 1 5 5 5 2 Vacuolar 14 Fab1-binding region HEAT PF02985.17 CDF90480.1 - 4.7e-08 32.4 19.0 0.46 10.7 0.0 10.8 13 0 0 13 13 13 3 HEAT repeat Proteasom_PSMB PF10508.4 CDF90480.1 - 0.027 12.7 0.1 0.5 8.5 0.0 2.7 3 0 0 3 3 3 0 Proteasome non-ATPase 26S subunit Cnd1 PF12717.2 CDF90480.1 - 0.23 11.3 3.2 13 5.5 0.0 4.6 5 0 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.15 CDF90481.1 - 9.3e-99 331.1 3.4 1.1e-98 330.8 2.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.1 CDF90481.1 - 3.1e-10 40.1 1.0 7.2e-06 26.2 0.2 3.8 3 1 1 4 4 4 2 HEAT repeats HEAT PF02985.17 CDF90481.1 - 1.8e-08 33.7 3.4 0.1 12.7 0.0 6.1 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.1 CDF90481.1 - 0.00038 20.8 1.2 6.1 7.4 0.0 4.3 2 1 2 4 4 4 1 HEAT-like repeat Cnd1 PF12717.2 CDF90481.1 - 0.00039 20.3 0.4 0.14 11.9 0.0 3.2 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Aminotran_4 PF01063.14 CDF90482.1 - 1.1e-25 90.4 0.0 7.1e-25 87.8 0.0 2.0 2 0 0 2 2 2 1 Aminotransferase class IV Kdo PF06293.9 CDF90483.1 - 2.6e-09 36.4 0.0 4.8e-09 35.5 0.0 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.20 CDF90483.1 - 4.7e-05 22.6 0.0 6.7e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.18 CDF90483.1 - 9.7e-05 22.2 0.0 0.0037 17.0 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.15 CDF90483.1 - 0.14 11.2 0.0 0.19 10.8 0.0 1.4 1 0 0 1 1 1 0 Ecdysteroid kinase DUF4135 PF13575.1 CDF90483.1 - 0.15 11.0 0.0 0.25 10.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) DUF2424 PF10340.4 CDF90484.1 - 2e-66 224.1 0.0 2.3e-66 223.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2424) Abhydrolase_3 PF07859.8 CDF90484.1 - 2.9e-20 72.7 0.0 5.2e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CDF90484.1 - 0.00017 21.3 0.0 0.00029 20.6 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family COesterase PF00135.23 CDF90484.1 - 0.023 13.3 0.0 1.7 7.2 0.0 2.1 2 0 0 2 2 2 0 Carboxylesterase family DEAD PF00270.24 CDF90485.1 - 1.7e-44 151.3 0.2 1.3e-43 148.4 0.0 2.3 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF90485.1 - 3.8e-22 77.9 0.0 7.3e-22 77.0 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 CDF90485.1 - 3.3e-20 71.3 0.3 6.3e-20 70.4 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.10 CDF90485.1 - 0.0038 17.0 0.0 0.012 15.4 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.9 CDF90485.1 - 0.024 13.9 0.0 0.073 12.3 0.0 1.7 1 1 0 1 1 1 0 SecA DEAD-like domain AAA_22 PF13401.1 CDF90485.1 - 0.086 12.9 1.0 0.32 11.1 0.5 2.2 2 1 0 2 2 2 0 AAA domain PhoD PF09423.5 CDF90486.1 - 2.3e-06 26.4 0.0 5.8e-06 25.1 0.0 1.6 1 1 0 1 1 1 1 PhoD-like phosphatase His_biosynth PF00977.16 CDF90486.1 - 0.16 11.1 0.0 0.27 10.4 0.0 1.2 1 0 0 1 1 1 0 Histidine biosynthesis protein Pkinase PF00069.20 CDF90487.1 - 1.7e-50 171.5 0.0 5.1e-50 170.0 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF90487.1 - 3.1e-22 78.8 0.0 1.6e-20 73.2 0.0 2.6 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF90487.1 - 0.0033 16.4 1.0 0.33 9.8 0.0 2.8 2 1 0 2 2 2 2 Kinase-like DcpS_C PF11969.3 CDF90487.1 - 0.072 13.3 0.1 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding GTP_cyclohydroI PF01227.17 CDF90488.1 - 8.4e-75 249.9 0.4 1e-74 249.7 0.2 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.1 CDF90488.1 - 0.00015 21.6 0.0 0.00034 20.4 0.0 1.6 1 0 0 1 1 1 1 QueF-like protein NUC129 PF08157.6 CDF90488.1 - 0.031 14.1 0.1 0.053 13.4 0.0 1.3 1 0 0 1 1 1 0 NUC129 domain DUF2703 PF10865.3 CDF90488.1 - 0.15 11.9 0.4 0.75 9.7 0.0 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF2703) DnaJ_CXXCXGXG PF00684.14 CDF90489.1 - 0.00016 21.6 4.3 0.15 12.1 0.1 2.4 2 0 0 2 2 2 2 DnaJ central domain HypA PF01155.14 CDF90489.1 - 0.14 11.8 1.0 1.4 8.6 0.1 2.1 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family zf-RING_5 PF14634.1 CDF90489.1 - 2.5 7.8 5.2 17 5.1 0.1 2.8 2 1 1 3 3 3 0 zinc-RING finger domain Ribosomal_L37e PF01907.14 CDF90489.1 - 3.4 7.5 11.3 7 6.5 3.5 2.3 2 0 0 2 2 2 0 Ribosomal protein L37e Got1 PF04178.7 CDF90490.1 - 9e-21 74.1 11.2 1e-20 73.9 7.7 1.0 1 0 0 1 1 1 1 Got1/Sft2-like family DUF973 PF06157.6 CDF90490.1 - 0.0096 14.9 2.7 0.011 14.6 1.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF973) DUF2614 PF11023.3 CDF90490.1 - 4.8 6.9 5.3 1.2 8.8 1.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2614) SdpI PF13630.1 CDF90490.1 - 5.4 6.8 14.3 2.4 7.9 1.0 2.5 2 1 0 2 2 2 0 SdpI/YhfL protein family DUF872 PF05915.7 CDF90490.1 - 6 6.7 7.1 0.72 9.7 1.3 2.1 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF872) AAA PF00004.24 CDF90491.1 - 1.5e-50 170.8 0.0 1.7e-42 144.7 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CDF90491.1 - 6.8e-07 29.4 0.2 1.4e-05 25.1 0.0 2.9 2 1 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.12 CDF90491.1 - 1.2e-06 28.1 0.0 2.9e-05 23.5 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_2 PF07724.9 CDF90491.1 - 1.5e-06 28.2 0.0 4.2e-05 23.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 CDF90491.1 - 3.8e-05 23.8 0.1 0.0018 18.4 0.1 2.9 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.1 CDF90491.1 - 0.00013 21.6 0.0 0.012 15.2 0.0 2.6 3 0 0 3 3 2 1 AAA domain AAA_19 PF13245.1 CDF90491.1 - 0.00016 21.3 0.2 0.015 15.0 0.0 3.1 3 0 0 3 3 3 1 Part of AAA domain Sigma54_activ_2 PF14532.1 CDF90491.1 - 0.00016 21.7 0.0 0.42 10.6 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain Bromodomain PF00439.20 CDF90491.1 - 0.00023 21.0 0.5 0.00095 19.0 0.0 2.2 2 0 0 2 2 2 1 Bromodomain AAA_5 PF07728.9 CDF90491.1 - 0.00046 19.9 0.0 0.0015 18.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 CDF90491.1 - 0.0014 18.0 0.0 0.0044 16.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 CDF90491.1 - 0.0026 17.6 0.0 0.027 14.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain ResIII PF04851.10 CDF90491.1 - 0.0041 16.9 0.0 0.02 14.7 0.0 2.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit TIP49 PF06068.8 CDF90491.1 - 0.0068 15.1 0.0 0.019 13.6 0.0 1.6 2 0 0 2 2 2 1 TIP49 C-terminus AAA_33 PF13671.1 CDF90491.1 - 0.012 15.5 0.0 0.036 13.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 CDF90491.1 - 0.013 15.6 0.0 0.076 13.1 0.0 2.3 2 0 0 2 2 2 0 RNA helicase PhoH PF02562.11 CDF90491.1 - 0.015 14.5 0.0 0.13 11.4 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein Sigma54_activat PF00158.21 CDF90491.1 - 0.023 14.1 0.0 1.5 8.3 0.0 2.9 3 0 0 3 3 3 0 Sigma-54 interaction domain ABC_tran PF00005.22 CDF90491.1 - 0.029 14.6 1.2 0.24 11.6 0.0 3.1 3 0 0 3 3 3 0 ABC transporter Mg_chelatase PF01078.16 CDF90491.1 - 0.034 13.3 0.1 0.13 11.3 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_17 PF13207.1 CDF90491.1 - 0.041 14.6 0.0 0.041 14.6 0.0 3.9 4 1 0 4 4 2 0 AAA domain Parvo_NS1 PF01057.12 CDF90491.1 - 0.048 12.5 0.0 0.56 9.0 0.0 2.1 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 RuvB_N PF05496.7 CDF90491.1 - 0.056 12.4 0.0 0.13 11.3 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus AAA_3 PF07726.6 CDF90491.1 - 0.12 12.0 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 CDF90491.1 - 0.14 12.4 0.0 0.14 12.4 0.0 3.3 3 1 0 3 3 1 0 AAA domain Amidase PF01425.16 CDF90492.1 - 6.7e-114 381.1 0.0 8e-114 380.8 0.0 1.0 1 0 0 1 1 1 1 Amidase Dynamitin PF04912.9 CDF90493.1 - 1.3e-07 30.8 8.5 1.3e-07 30.8 5.9 2.1 1 1 1 2 2 2 2 Dynamitin Laminin_II PF06009.7 CDF90493.1 - 0.32 10.7 11.1 0.12 12.1 0.6 3.4 2 1 2 4 4 4 0 Laminin Domain II DUF310 PF03750.8 CDF90493.1 - 3.8 7.7 6.3 1.7 8.8 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF310) TPR_MLP1_2 PF07926.7 CDF90493.1 - 7.3 6.3 18.9 2 8.1 4.5 3.3 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein Sec63 PF02889.11 CDF90494.1 - 1e-134 448.6 0.9 3.6e-91 305.6 0.1 2.4 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.24 CDF90494.1 - 2e-53 180.3 1.1 2.3e-28 98.7 0.3 4.1 5 0 0 5 5 5 2 DEAD/DEAH box helicase ResIII PF04851.10 CDF90494.1 - 9.1e-21 74.5 0.0 3.6e-10 39.9 0.1 2.8 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.26 CDF90494.1 - 1e-16 60.5 0.1 5.1e-07 29.4 0.0 3.0 3 0 0 3 3 3 2 Helicase conserved C-terminal domain SNF2_N PF00176.18 CDF90494.1 - 3.1e-07 29.4 0.1 0.0014 17.4 0.1 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain AAA PF00004.24 CDF90494.1 - 7.9e-06 26.1 0.1 0.033 14.3 0.0 4.4 4 2 0 4 4 2 1 ATPase family associated with various cellular activities (AAA) PhoH PF02562.11 CDF90494.1 - 2.9e-05 23.3 0.1 0.013 14.7 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein AAA_22 PF13401.1 CDF90494.1 - 3.2e-05 24.0 5.2 0.22 11.6 0.0 4.3 3 2 0 3 3 3 2 AAA domain AAA_19 PF13245.1 CDF90494.1 - 0.00016 21.3 0.0 0.083 12.6 0.0 2.6 2 0 0 2 2 2 1 Part of AAA domain IstB_IS21 PF01695.12 CDF90494.1 - 0.00017 21.0 0.2 0.83 9.0 0.0 3.9 4 0 0 4 4 4 2 IstB-like ATP binding protein Zeta_toxin PF06414.7 CDF90494.1 - 0.0075 15.3 0.0 1.8 7.5 0.0 3.4 4 0 0 4 4 4 1 Zeta toxin AAA_18 PF13238.1 CDF90494.1 - 0.058 13.7 0.0 0.58 10.4 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 CDF90494.1 - 0.2 11.0 3.2 24 4.2 0.0 4.1 4 2 1 6 6 6 0 AAA-like domain DUF2361 PF10153.4 CDF90495.1 - 1.2e-31 109.2 19.0 2.3e-31 108.3 12.2 2.1 2 1 0 2 2 2 1 Uncharacterised conserved protein (DUF2361) Phage_int_SAM_2 PF12834.2 CDF90495.1 - 0.035 14.4 1.5 0.32 11.3 0.9 2.1 2 0 0 2 2 2 0 Phage integrase, N-terminal DUF2406 PF10295.4 CDF90496.1 - 1.7e-24 86.1 0.2 3e-24 85.3 0.1 1.4 1 0 0 1 1 1 1 Uncharacterised protein (DUF2406) Aminotran_1_2 PF00155.16 CDF90497.1 - 1.4e-66 224.9 0.0 1.7e-66 224.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Peptidase_S10 PF00450.17 CDF90498.1 - 2.1e-127 425.7 0.7 2.5e-127 425.4 0.5 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.6 CDF90498.1 - 1e-19 70.7 0.0 1.7e-19 70.0 0.0 1.4 1 0 0 1 1 1 1 Carboxypeptidase Y pro-peptide Abhydrolase_6 PF12697.2 CDF90498.1 - 0.00061 19.7 0.0 0.027 14.3 0.0 2.5 2 1 0 2 2 2 1 Alpha/beta hydrolase family DUF3591 PF12157.3 CDF90500.1 - 1.6e-193 643.2 0.2 2.5e-193 642.6 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC_6 PF15288.1 CDF90500.1 - 1.1e-05 24.9 1.8 2.4e-05 23.8 1.2 1.6 1 0 0 1 1 1 1 Zinc knuckle DUF4073 PF13285.1 CDF90500.1 - 0.016 14.6 0.2 1.3 8.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4073) zf-CCHC PF00098.18 CDF90500.1 - 0.75 9.8 2.0 0.52 10.3 0.2 1.7 2 0 0 2 2 2 0 Zinc knuckle Rtt102p PF09510.5 CDF90501.1 - 2e-25 89.2 1.2 2e-25 89.2 0.9 1.6 2 0 0 2 2 2 1 Rtt102p-like transcription regulator protein RNase_T PF00929.19 CDF90502.1 - 2.5e-24 86.4 0.5 8.2e-24 84.7 0.1 2.0 2 0 0 2 2 2 1 Exonuclease DLIC PF05783.6 CDF90503.1 - 6.2e-07 28.4 0.0 9.4e-07 27.8 0.0 1.3 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) GATase_2 PF00310.16 CDF90504.1 - 3.7e-24 85.0 0.2 3.9e-19 68.5 0.0 2.3 1 1 1 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.1 CDF90504.1 - 1.7e-14 53.8 0.0 4.5e-14 52.5 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.22 CDF90504.1 - 5.2e-13 48.8 0.1 9.3e-13 47.9 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_7 PF13537.1 CDF90504.1 - 1e-11 44.6 0.0 2.3e-11 43.5 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.1 CDF90504.1 - 3.3e-06 26.0 0.0 5.3e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II ABC_membrane PF00664.18 CDF90505.1 - 6e-37 127.5 10.9 7.5e-37 127.2 7.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 CDF90505.1 - 4.2e-32 111.3 0.0 9.3e-32 110.1 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 CDF90505.1 - 9.6e-09 35.6 0.0 0.00078 19.4 0.0 3.3 2 1 0 3 3 3 2 AAA domain SMC_N PF02463.14 CDF90505.1 - 2.5e-08 33.4 0.0 4.8e-05 22.6 0.0 2.2 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 CDF90505.1 - 6.2e-06 26.3 0.0 1.8e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain ABC_ATPase PF09818.4 CDF90505.1 - 0.00014 20.6 0.0 0.0083 14.7 0.0 2.2 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_10 PF12846.2 CDF90505.1 - 0.0003 20.3 0.3 0.00077 18.9 0.2 1.7 1 1 0 1 1 1 1 AAA-like domain AAA_22 PF13401.1 CDF90505.1 - 0.0004 20.5 0.0 0.0027 17.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CDF90505.1 - 0.00066 20.4 0.1 0.0035 18.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 CDF90505.1 - 0.00072 19.0 0.1 0.0017 17.8 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.1 CDF90505.1 - 0.0024 17.3 0.0 0.0051 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain Gtr1_RagA PF04670.7 CDF90505.1 - 0.0074 15.4 0.0 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_14 PF13173.1 CDF90505.1 - 0.014 15.2 0.0 0.1 12.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain MobB PF03205.9 CDF90505.1 - 0.033 13.8 0.0 0.069 12.8 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA PF00004.24 CDF90505.1 - 0.046 13.9 0.0 0.28 11.3 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 CDF90505.1 - 0.052 13.4 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 CDF90505.1 - 0.078 12.1 0.0 0.24 10.5 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF258 DUF3987 PF13148.1 CDF90505.1 - 0.079 11.5 0.5 0.2 10.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) SbcCD_C PF13558.1 CDF90505.1 - 0.12 12.3 0.3 0.66 9.9 0.2 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.1 CDF90505.1 - 0.12 11.8 0.0 0.37 10.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.1 CDF90505.1 - 2.2 8.5 8.8 0.78 10.0 0.1 2.6 3 0 0 3 3 2 0 AAA domain RNA12 PF10443.4 CDF90506.1 - 1e-168 561.3 5.1 1.3e-168 561.0 0.9 2.2 2 0 0 2 2 2 1 RNA12 protein AAA_14 PF13173.1 CDF90506.1 - 8.7e-06 25.6 0.3 0.00053 19.9 0.0 3.2 3 0 0 3 3 3 1 AAA domain Arch_ATPase PF01637.13 CDF90506.1 - 1.8e-05 24.5 1.9 0.00013 21.7 0.2 3.0 1 1 1 2 2 2 1 Archaeal ATPase RRM_1 PF00076.17 CDF90506.1 - 0.003 17.1 0.0 0.0076 15.8 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_22 PF13401.1 CDF90506.1 - 0.09 12.9 0.1 1.3 9.1 0.0 2.8 1 1 1 2 2 2 0 AAA domain USP7_C2 PF14533.1 CDF90507.1 - 5.1e-58 195.9 7.0 2.4e-56 190.5 1.0 3.4 3 1 0 3 3 3 2 Ubiquitin-specific protease C-terminal UCH PF00443.24 CDF90507.1 - 1e-51 175.6 2.5 2.1e-51 174.5 1.7 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.3 CDF90507.1 - 3.5e-36 124.7 3.3 1.1e-35 123.0 0.9 2.5 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 UCH_1 PF13423.1 CDF90507.1 - 2.4e-34 119.1 0.0 3.9e-34 118.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UN_NPL4 PF11543.3 CDF90507.1 - 0.0021 18.3 0.1 0.096 12.9 0.1 3.1 2 0 0 2 2 2 1 Nuclear pore localisation protein NPL4 rve PF00665.21 CDF90507.1 - 0.0096 16.0 0.0 0.028 14.5 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain Telomere_Sde2 PF13019.1 CDF90507.1 - 0.029 14.0 0.0 22 4.6 0.0 3.5 3 0 0 3 3 3 0 Telomere stability and silencing CTP_transf_2 PF01467.21 CDF90508.1 - 8.1e-15 55.2 0.0 1.2e-14 54.6 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase MA3 PF02847.12 CDF90509.1 - 1.2e-19 70.0 1.5 2.3e-17 62.7 0.0 2.8 2 1 0 2 2 2 2 MA3 domain MIF4G PF02854.14 CDF90509.1 - 1.3e-16 60.6 4.0 1.3e-16 60.6 2.8 1.8 2 0 0 2 2 2 1 MIF4G domain Glyco_hydro_17 PF00332.13 CDF90510.1 - 1.6e-10 40.5 0.2 2.8e-10 39.7 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 Tmemb_cc2 PF10267.4 CDF90510.1 - 4.2 5.8 6.0 5.8 5.4 4.2 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein PAP1 PF08601.5 CDF90510.1 - 6.5 6.3 15.4 8.5 5.9 10.1 1.5 2 0 0 2 2 2 0 Transcription factor PAP1 Glucan_synthase PF02364.10 CDF90511.1 - 0 1330.7 41.4 0 1012.5 4.5 3.6 2 2 1 3 3 3 2 1,3-beta-glucan synthase component FKS1_dom1 PF14288.1 CDF90511.1 - 9.1e-36 122.3 3.7 3.9e-17 62.2 0.1 3.5 3 0 0 3 3 3 2 1,3-beta-glucan synthase subunit FKS1, domain-1 Glyco_hydro_72 PF03198.9 CDF90512.1 - 9.8e-148 491.2 11.2 1.4e-147 490.7 7.8 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.8 CDF90512.1 - 5.1e-27 94.1 6.7 5.1e-27 94.1 4.7 2.5 2 0 0 2 2 2 1 X8 domain Cellulase PF00150.13 CDF90512.1 - 1.2e-05 24.6 1.1 4.9e-05 22.6 0.8 1.8 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.12 CDF90512.1 - 2.6e-05 23.2 0.8 4.1e-05 22.6 0.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Pex14_N PF04695.8 CDF90512.1 - 3.7 7.6 10.0 0.25 11.3 3.2 1.9 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Apt1 PF10351.4 CDF90512.1 - 4.5 6.0 8.3 8.1 5.1 5.8 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain G-patch PF01585.18 CDF90514.1 - 1.3e-12 47.2 0.0 3.6e-12 45.8 0.0 1.8 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.2 CDF90514.1 - 1.3e-05 24.9 0.1 1.3e-05 24.9 0.1 3.0 3 1 0 3 3 3 1 DExH-box splicing factor binding site RNA_polI_A34 PF08208.6 CDF90514.1 - 3.6 7.2 16.5 5.4 6.6 11.4 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 TRM PF02005.11 CDF90516.1 - 5.4e-144 479.7 0.0 6.2e-144 479.5 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.11 CDF90516.1 - 4.5e-06 26.4 0.0 8.2e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_26 PF13659.1 CDF90516.1 - 0.12 12.4 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain CBFD_NFYB_HMF PF00808.18 CDF90517.1 - 0.006 16.6 0.2 0.0099 15.9 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Nyv1_N PF09426.5 CDF90518.1 - 2e-48 163.5 0.0 3e-48 163.0 0.0 1.2 1 0 0 1 1 1 1 Vacuolar R-SNARE Nyv1 N terminal Synaptobrevin PF00957.16 CDF90518.1 - 8.1e-24 83.0 0.3 1.3e-23 82.3 0.2 1.3 1 0 0 1 1 1 1 Synaptobrevin PepSY_TM_2 PF13703.1 CDF90518.1 - 0.017 15.3 0.4 0.033 14.3 0.3 1.4 1 0 0 1 1 1 0 PepSY-associated TM helix KAR PF15222.1 CDF90518.1 - 0.084 12.9 0.3 0.25 11.4 0.2 1.7 1 1 1 2 2 2 0 Kidney androgen-regulated SPR1 PF15356.1 CDF90519.1 - 0.047 14.0 0.9 0.11 12.8 0.6 1.6 1 0 0 1 1 1 0 Psoriasis susceptibility locus 2 Pkinase PF00069.20 CDF90521.1 - 1.2e-71 240.9 1.1 1.2e-71 240.9 0.8 2.7 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF90521.1 - 5.3e-40 137.1 0.3 5.3e-40 137.1 0.2 2.7 2 1 0 2 2 2 1 Protein tyrosine kinase KA1 PF02149.14 CDF90521.1 - 9e-20 69.8 0.0 1.8e-19 68.9 0.0 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.1 CDF90521.1 - 1.5e-06 27.4 0.0 1.5e-06 27.4 0.0 1.7 2 0 0 2 2 2 1 Kinase-like APH PF01636.18 CDF90521.1 - 2.9e-05 23.9 5.1 0.019 14.7 0.0 3.1 2 1 0 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 CDF90521.1 - 4.5e-05 22.6 0.1 0.00012 21.2 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.6 CDF90521.1 - 0.027 13.6 0.1 0.05 12.8 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Mem_trans PF03547.13 CDF90521.1 - 0.79 7.9 4.4 4.1 5.5 0.1 2.4 2 0 0 2 2 2 0 Membrane transport protein HLH PF00010.21 CDF90522.1 - 0.011 15.4 0.1 0.02 14.5 0.1 1.5 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain STOP PF05217.7 CDF90522.1 - 0.084 12.5 0.2 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 STOP protein F-box-like PF12937.2 CDF90523.1 - 3e-05 23.6 0.2 6e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 F-box-like MIT PF04212.13 CDF90523.1 - 0.0016 18.3 0.5 0.0032 17.3 0.3 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain TPR_1 PF00515.23 CDF90523.1 - 0.013 15.1 0.8 3.8 7.2 0.1 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat F-box PF00646.28 CDF90523.1 - 0.025 14.2 0.4 0.055 13.1 0.3 1.5 1 0 0 1 1 1 0 F-box domain TPR_11 PF13414.1 CDF90523.1 - 0.026 14.1 0.4 0.56 9.8 0.1 2.4 1 1 1 2 2 2 0 TPR repeat TPR_2 PF07719.12 CDF90523.1 - 0.072 13.0 0.8 12 6.0 0.1 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat SLD3 PF08639.5 CDF90523.1 - 0.13 10.8 0.5 0.17 10.4 0.3 1.1 1 0 0 1 1 1 0 DNA replication regulator SLD3 DUF2841 PF11001.3 CDF90524.1 - 2.9e-38 130.5 1.8 3e-38 130.5 0.3 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2841) Fungal_trans PF04082.13 CDF90525.1 - 1.6e-36 125.4 1.7 3e-36 124.6 1.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF90525.1 - 4e-09 36.2 10.4 6.9e-09 35.4 7.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain F-box-like_2 PF13013.1 CDF90525.1 - 0.2 11.3 2.4 0.4 10.4 0.2 2.5 3 0 0 3 3 3 0 F-box-like domain Abhydrolase_6 PF12697.2 CDF90526.1 - 1e-22 81.1 0.0 1.8e-22 80.3 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDF90526.1 - 2e-15 56.9 0.0 4.6e-10 39.4 0.0 2.5 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CDF90526.1 - 3.9e-12 46.1 0.0 2.1e-11 43.7 0.0 2.1 2 1 0 2 2 2 1 Alpha/beta hydrolase family DUF915 PF06028.6 CDF90526.1 - 1.3e-07 30.9 1.1 5.8e-07 28.8 0.7 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Thioesterase PF00975.15 CDF90526.1 - 0.0017 18.6 0.0 0.0082 16.3 0.0 2.0 2 0 0 2 2 2 1 Thioesterase domain Esterase PF00756.15 CDF90526.1 - 0.0018 17.7 0.0 0.0031 16.9 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Ndr PF03096.9 CDF90526.1 - 0.004 15.6 0.0 0.017 13.6 0.0 1.9 3 0 0 3 3 3 1 Ndr family DLH PF01738.13 CDF90526.1 - 0.0081 15.4 0.0 0.015 14.5 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.3 CDF90526.1 - 0.013 15.3 0.0 0.029 14.2 0.0 1.6 1 0 0 1 1 1 0 Putative lysophospholipase DUF2305 PF10230.4 CDF90526.1 - 0.015 14.6 0.0 0.031 13.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2305) BAAT_C PF08840.6 CDF90526.1 - 0.025 14.2 0.0 1.9 8.1 0.0 2.3 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal PGAP1 PF07819.8 CDF90526.1 - 0.1 12.1 0.0 0.24 10.9 0.0 1.7 1 1 0 1 1 1 0 PGAP1-like protein HAP1_N PF04849.8 CDF90527.1 - 0.015 14.2 1.8 0.019 13.9 1.3 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region zf-DHHC PF01529.15 CDF90528.1 - 2.6e-29 101.8 14.6 2.6e-29 101.8 10.1 1.9 1 1 1 2 2 2 1 DHHC palmitoyltransferase PGG PF13962.1 CDF90528.1 - 0.044 13.4 7.2 0.12 11.9 2.3 2.4 2 0 0 2 2 2 0 Domain of unknown function Mpv17_PMP22 PF04117.7 CDF90528.1 - 0.13 11.9 2.1 0.29 10.7 0.9 2.1 2 0 0 2 2 2 0 Mpv17 / PMP22 family Yip1 PF04893.12 CDF90528.1 - 5.5 6.4 11.5 1.6 8.2 0.3 3.0 2 1 0 3 3 3 0 Yip1 domain EPSP_synthase PF00275.15 CDF90529.1 - 2.8e-133 444.3 0.1 4.3e-133 443.8 0.0 1.2 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.15 CDF90529.1 - 6.6e-99 330.0 0.0 1.1e-98 329.3 0.0 1.3 1 0 0 1 1 1 1 3-dehydroquinate synthase DHquinase_I PF01487.10 CDF90529.1 - 1.9e-68 230.4 0.0 4e-68 229.4 0.0 1.6 2 0 0 2 2 2 1 Type I 3-dehydroquinase SKI PF01202.17 CDF90529.1 - 2.8e-38 131.2 0.1 5.6e-37 127.0 0.0 2.5 2 0 0 2 2 2 1 Shikimate kinase Shikimate_dh_N PF08501.6 CDF90529.1 - 1.3e-19 70.0 0.0 8.1e-19 67.4 0.0 2.5 3 0 0 3 3 3 1 Shikimate dehydrogenase substrate binding domain Shikimate_DH PF01488.15 CDF90529.1 - 1.1e-15 57.8 0.0 3.9e-15 56.1 0.0 1.9 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Fe-ADH_2 PF13685.1 CDF90529.1 - 1.4e-07 31.0 0.0 3.1e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase AAA_17 PF13207.1 CDF90529.1 - 0.00031 21.5 0.0 0.00088 20.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CDF90529.1 - 0.0019 18.0 0.0 0.005 16.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain 6PF2K PF01591.13 CDF90529.1 - 0.044 12.8 0.0 0.1 11.6 0.0 1.5 1 0 0 1 1 1 0 6-phosphofructo-2-kinase DUF3702 PF12486.3 CDF90529.1 - 0.13 11.9 0.0 6.9 6.3 0.0 2.3 2 0 0 2 2 2 0 ImpA domain protein WD40 PF00400.27 CDF90530.1 - 1e-16 60.1 16.4 2e-06 27.4 0.0 6.8 6 0 0 6 6 6 4 WD domain, G-beta repeat RWD PF05773.17 CDF90530.1 - 2.4e-05 24.1 0.1 7.3e-05 22.6 0.1 1.8 1 0 0 1 1 1 1 RWD domain C1_3 PF07649.7 CDF90530.1 - 0.0026 17.7 5.3 0.0059 16.6 3.7 1.7 1 0 0 1 1 1 1 C1-like domain zf-RING_2 PF13639.1 CDF90530.1 - 0.31 10.9 13.2 0.97 9.3 9.2 1.9 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.1 CDF90530.1 - 6.5 6.5 11.6 15 5.3 8.0 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CDF90530.1 - 7.1 6.7 14.3 17 5.5 9.9 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) adh_short PF00106.20 CDF90531.1 - 1.1e-05 25.4 0.0 0.0012 18.7 0.0 2.2 1 1 0 2 2 2 2 short chain dehydrogenase CRAL_TRIO_2 PF13716.1 CDF90531.1 - 0.5 10.2 2.5 1.8 8.4 0.1 2.3 2 0 0 2 2 2 0 Divergent CRAL/TRIO domain CH PF00307.26 CDF90532.1 - 1e-67 224.9 0.3 2.4e-18 66.1 0.2 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain CAMSAP_CH PF11971.3 CDF90532.1 - 0.0017 17.9 0.1 4.4 7.0 0.0 3.6 3 0 0 3 3 3 1 CAMSAP CH domain EF-hand_7 PF13499.1 CDF90532.1 - 0.0043 17.1 0.1 0.098 12.8 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.27 CDF90532.1 - 0.047 13.0 0.2 7.5 6.1 0.0 3.5 2 1 0 3 3 3 0 EF hand EF-hand_6 PF13405.1 CDF90532.1 - 0.061 13.2 0.2 6.2 6.9 0.0 3.5 3 0 0 3 3 3 0 EF-hand domain Apc9 PF12856.2 CDF90533.1 - 2.2e-20 72.5 0.1 4.5e-20 71.5 0.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 9 CDC45 PF02724.9 CDF90534.1 - 9.1e-209 694.5 0.5 1e-208 694.3 0.3 1.0 1 0 0 1 1 1 1 CDC45-like protein IFT57 PF10498.4 CDF90534.1 - 0.012 14.3 7.4 0.018 13.7 5.1 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Prothymosin PF03247.9 CDF90534.1 - 0.64 10.1 21.4 1.1 9.4 14.9 1.3 1 0 0 1 1 1 0 Prothymosin/parathymosin family Daxx PF03344.10 CDF90534.1 - 7.9 4.8 15.4 11 4.3 10.7 1.1 1 0 0 1 1 1 0 Daxx Family tRNA_int_endo PF01974.12 CDF90536.1 - 2.1e-24 85.1 0.1 3.8e-24 84.2 0.1 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.9 CDF90536.1 - 0.086 12.4 0.1 1.2 8.7 0.0 2.5 3 0 0 3 3 3 0 tRNA intron endonuclease, N-terminal domain DUF972 PF06156.8 CDF90536.1 - 0.11 12.8 2.5 0.19 12.0 1.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF972) RNase_T PF00929.19 CDF90537.1 - 1.2e-16 61.4 0.2 2.4e-15 57.1 0.0 2.4 2 0 0 2 2 2 1 Exonuclease DNA_pol_A_exo1 PF01612.15 CDF90537.1 - 0.0017 17.8 0.1 0.0068 15.8 0.0 2.0 1 1 0 1 1 1 1 3'-5' exonuclease CHORD PF04968.7 CDF90537.1 - 0.095 12.9 6.4 0.19 12.0 4.5 1.5 1 0 0 1 1 1 0 CHORD zf-CSL PF05207.8 CDF90537.1 - 2.2 7.8 6.4 28 4.3 2.2 2.8 2 1 0 2 2 2 0 CSL zinc finger PEPCK_ATP PF01293.15 CDF90539.1 - 0.037 12.5 0.0 0.067 11.7 0.0 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase BTB_2 PF02214.17 CDF90540.1 - 1.1e-09 38.3 0.1 5.9e-05 23.1 0.1 3.0 2 1 0 2 2 2 2 BTB/POZ domain Defensin_big PF14862.1 CDF90540.1 - 0.099 12.7 0.2 0.85 9.7 1.0 1.9 2 0 0 2 2 2 0 Big defensin Redoxin PF08534.5 CDF90541.1 - 4.2e-29 100.9 0.1 4.8e-29 100.7 0.1 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 CDF90541.1 - 5.1e-10 39.1 0.0 6.7e-10 38.7 0.0 1.3 1 1 0 1 1 1 1 AhpC/TSA family ABC_membrane PF00664.18 CDF90544.1 - 3e-91 305.6 31.1 1.6e-50 172.0 5.8 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.22 CDF90544.1 - 1.9e-49 167.4 0.1 2.9e-30 105.3 0.1 3.1 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 CDF90544.1 - 1.4e-09 37.4 5.5 0.001 18.3 0.3 4.2 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 CDF90544.1 - 7.8e-06 26.0 4.7 0.018 15.0 0.1 3.1 3 0 0 3 3 3 2 AAA ATPase domain MMR_HSR1 PF01926.18 CDF90544.1 - 2.3e-05 24.3 0.1 0.2 11.6 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.1 CDF90544.1 - 0.00019 20.8 0.1 0.8 9.2 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_25 PF13481.1 CDF90544.1 - 0.00023 20.6 0.0 0.42 9.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain Miro PF08477.8 CDF90544.1 - 0.00064 20.2 0.5 1.4 9.4 0.0 3.0 2 0 0 2 2 2 2 Miro-like protein AAA_10 PF12846.2 CDF90544.1 - 0.00067 19.1 2.2 5.3 6.3 0.0 3.6 2 1 0 3 3 3 1 AAA-like domain AAA_23 PF13476.1 CDF90544.1 - 0.00072 19.9 7.0 0.008 16.5 0.2 3.2 3 0 0 3 3 3 1 AAA domain DUF258 PF03193.11 CDF90544.1 - 0.0021 17.2 0.1 1.2 8.2 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 T2SE PF00437.15 CDF90544.1 - 0.019 13.8 0.0 0.28 10.0 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein TrwB_AAD_bind PF10412.4 CDF90544.1 - 0.042 12.4 0.5 1.3 7.6 0.0 2.9 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain MobB PF03205.9 CDF90544.1 - 0.045 13.4 2.1 6.9 6.3 0.0 2.9 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.1 CDF90544.1 - 0.06 13.4 3.8 16 5.6 0.0 3.8 3 1 0 3 3 3 0 AAA domain AAA_17 PF13207.1 CDF90544.1 - 0.081 13.7 0.1 5 7.9 0.0 3.0 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 CDF90544.1 - 0.16 11.4 0.0 18 4.7 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family Dynamin_N PF00350.18 CDF90544.1 - 0.2 11.4 10.5 0.54 10.0 0.1 4.2 4 0 0 4 4 4 0 Dynamin family AIG1 PF04548.11 CDF90544.1 - 0.22 10.6 0.0 0.22 10.6 0.0 2.8 3 0 0 3 3 2 0 AIG1 family Arch_ATPase PF01637.13 CDF90544.1 - 0.29 10.8 0.0 0.29 10.8 0.0 3.1 5 0 0 5 5 4 0 Archaeal ATPase AAA_30 PF13604.1 CDF90544.1 - 0.42 10.1 1.9 13 5.2 0.4 2.9 2 1 0 2 2 2 0 AAA domain DUF87 PF01935.12 CDF90544.1 - 1.8 8.3 11.6 0.43 10.3 0.1 3.4 4 0 0 4 4 4 0 Domain of unknown function DUF87 Avl9 PF09794.4 CDF90545.1 - 1.6e-144 481.0 0.5 2.3e-144 480.5 0.4 1.2 1 0 0 1 1 1 1 Transport protein Avl9 SPA PF08616.5 CDF90545.1 - 9.1e-06 25.3 0.6 0.14 11.8 0.0 3.1 3 0 0 3 3 3 2 Stabilization of polarity axis DENN PF02141.16 CDF90545.1 - 0.039 13.6 0.5 0.99 9.1 0.1 2.5 2 0 0 2 2 2 0 DENN (AEX-3) domain efThoc1 PF11957.3 CDF90546.1 - 2.1e-80 270.6 16.5 2.1e-80 270.6 11.4 1.7 1 1 1 2 2 2 1 THO complex subunit 1 transcription elongation factor CPSF100_C PF13299.1 CDF90548.1 - 3.9e-37 127.9 0.3 3.9e-37 127.9 0.2 2.3 2 0 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.3 CDF90548.1 - 1.6e-10 40.9 0.0 4.8e-10 39.4 0.0 1.9 1 1 0 1 1 1 1 Beta-Casp domain RRM_3 PF08777.6 CDF90548.1 - 0.027 14.2 0.2 0.097 12.5 0.1 1.9 1 0 0 1 1 1 0 RNA binding motif zf-CCHC_3 PF13917.1 CDF90549.1 - 7.3e-07 28.8 4.3 0.00038 20.1 0.2 2.7 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC PF00098.18 CDF90549.1 - 8.3e-06 25.4 7.0 0.00089 19.0 0.2 2.3 2 0 0 2 2 2 2 Zinc knuckle KH_1 PF00013.24 CDF90549.1 - 9.6e-06 25.1 0.0 2.1e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 CDF90549.1 - 1e-05 25.0 0.1 2.4e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 KH domain zf-CCHC_4 PF14392.1 CDF90549.1 - 0.12 12.0 5.2 0.88 9.2 0.3 2.5 2 0 0 2 2 2 0 Zinc knuckle TPR_14 PF13428.1 CDF90550.1 - 1.6e-22 77.9 0.1 0.045 14.4 0.0 10.1 6 2 6 12 12 11 6 Tetratricopeptide repeat TPR_16 PF13432.1 CDF90550.1 - 1.3e-20 73.4 0.0 0.00034 21.2 0.0 7.0 7 1 0 7 7 7 4 Tetratricopeptide repeat HAT PF02184.11 CDF90550.1 - 2.3e-18 65.6 39.7 2.2e-05 24.0 1.9 9.2 9 0 0 9 9 9 5 HAT (Half-A-TPR) repeat TPR_19 PF14559.1 CDF90550.1 - 8.7e-12 45.2 0.0 0.028 14.7 0.0 5.7 5 1 2 7 7 6 4 Tetratricopeptide repeat TPR_2 PF07719.12 CDF90550.1 - 1.3e-10 40.3 8.6 5.6 7.1 0.0 9.8 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_7 PF13176.1 CDF90550.1 - 8.3e-10 37.7 3.6 0.13 12.1 0.0 7.1 6 0 0 6 6 6 2 Tetratricopeptide repeat Suf PF05843.9 CDF90550.1 - 1.4e-09 38.1 27.5 0.0082 15.9 1.0 6.9 2 2 3 5 5 5 4 Suppressor of forked protein (Suf) TPR_8 PF13181.1 CDF90550.1 - 6.5e-09 34.9 0.2 6.8 6.7 0.0 8.1 7 1 1 8 8 8 1 Tetratricopeptide repeat TPR_12 PF13424.1 CDF90550.1 - 5.2e-08 32.7 9.4 0.76 9.7 0.0 7.8 8 1 0 8 8 8 2 Tetratricopeptide repeat TPR_11 PF13414.1 CDF90550.1 - 1.1e-07 31.4 1.3 0.0026 17.3 0.0 5.6 7 0 0 7 7 7 1 TPR repeat TPR_17 PF13431.1 CDF90550.1 - 1.1e-07 31.4 0.9 3.4e-05 23.7 0.2 4.7 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_15 PF13429.1 CDF90550.1 - 1.9e-07 30.4 6.9 0.00087 18.4 0.0 4.5 4 1 1 5 5 5 3 Tetratricopeptide repeat U3_assoc_6 PF08640.6 CDF90550.1 - 7.6e-05 22.4 25.7 0.0055 16.4 1.3 7.0 6 2 2 8 8 8 2 U3 small nucleolar RNA-associated protein 6 TPR_6 PF13174.1 CDF90550.1 - 0.00037 20.7 6.1 8.6 7.0 0.0 6.9 8 0 0 8 8 6 1 Tetratricopeptide repeat TPR_1 PF00515.23 CDF90550.1 - 0.0018 17.7 0.8 5.9 6.6 0.1 5.8 8 0 0 8 8 8 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 CDF90550.1 - 0.24 11.2 5.0 29 4.6 0.1 5.4 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat ubiquitin PF00240.18 CDF90551.1 - 1.2e-22 79.0 0.6 1.4e-22 78.8 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 CDF90551.1 - 9.5e-16 57.2 0.6 1e-15 57.1 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 CDF90551.1 - 0.00032 20.9 0.1 0.001 19.2 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain TUG-UBL1 PF11470.3 CDF90551.1 - 0.023 14.6 0.0 0.025 14.5 0.0 1.2 1 0 0 1 1 1 0 GLUT4 regulating protein TUG Methyltransf_26 PF13659.1 CDF90552.1 - 2e-13 50.4 0.0 2.7e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CDF90552.1 - 2.3e-08 33.5 0.0 2.7e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.1 CDF90552.1 - 1.8e-07 30.8 0.0 2.3e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 CDF90552.1 - 0.0017 17.5 0.0 0.016 14.3 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.7 CDF90552.1 - 0.0085 16.5 0.0 0.12 12.8 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDF90552.1 - 0.0094 15.6 0.0 0.21 11.3 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDF90552.1 - 0.067 13.5 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Dopey_N PF04118.9 CDF90553.1 - 4.6e-119 396.7 2.6 4.9e-119 396.6 0.3 2.2 2 0 0 2 2 2 1 Dopey, N-terminal Abhydrolase_2 PF02230.11 CDF90554.1 - 5.9e-60 202.3 0.2 6.6e-60 202.2 0.1 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.2 CDF90554.1 - 1.5e-12 47.5 0.0 1.9e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.8 CDF90554.1 - 6.1e-10 38.9 0.0 1.2e-09 37.9 0.0 1.5 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.2 CDF90554.1 - 1.4e-08 34.8 0.0 2.3e-07 30.9 0.0 2.0 1 1 1 2 2 2 1 Alpha/beta hydrolase family DLH PF01738.13 CDF90554.1 - 8.1e-05 21.9 0.0 0.00056 19.2 0.0 2.0 2 0 0 2 2 2 1 Dienelactone hydrolase family Peptidase_S9 PF00326.16 CDF90554.1 - 0.0018 17.5 0.4 0.45 9.7 0.0 2.6 2 1 1 3 3 3 2 Prolyl oligopeptidase family Abhydrolase_3 PF07859.8 CDF90554.1 - 0.0018 17.8 0.0 0.0032 17.0 0.0 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF2974 PF11187.3 CDF90554.1 - 0.013 14.8 0.0 0.028 13.7 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) AXE1 PF05448.7 CDF90554.1 - 0.013 13.9 0.0 0.022 13.2 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Cutinase PF01083.17 CDF90554.1 - 0.025 14.2 0.0 0.042 13.5 0.0 1.5 1 0 0 1 1 1 0 Cutinase Esterase PF00756.15 CDF90554.1 - 0.029 13.7 0.0 0.04 13.3 0.0 1.2 1 0 0 1 1 1 0 Putative esterase DUF2920 PF11144.3 CDF90554.1 - 0.037 13.0 0.0 0.045 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Lipase_3 PF01764.20 CDF90554.1 - 0.06 12.9 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Mod_r PF07200.8 CDF90555.1 - 8.3e-18 64.7 12.5 9.8e-18 64.4 8.7 1.0 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein PilJ PF13675.1 CDF90555.1 - 0.039 14.2 7.8 1.6 9.0 5.0 2.2 1 1 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term Occludin_ELL PF07303.8 CDF90555.1 - 0.066 13.9 11.5 0.5 11.1 2.9 2.1 1 1 1 2 2 2 0 Occludin homology domain Tropomyosin_1 PF12718.2 CDF90555.1 - 0.074 12.8 7.7 0.055 13.3 0.7 2.1 1 1 1 2 2 2 0 Tropomyosin like YvfG PF09628.5 CDF90555.1 - 0.11 12.6 0.1 1.3 9.2 0.0 2.3 2 0 0 2 2 2 0 YvfG protein DUF4140 PF13600.1 CDF90555.1 - 0.27 11.6 4.1 0.19 12.1 0.6 2.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) FCH PF00611.18 CDF90555.1 - 0.3 11.2 8.7 8.6 6.6 0.2 3.1 1 1 2 3 3 3 0 Fes/CIP4, and EFC/F-BAR homology domain Cor1 PF04803.7 CDF90555.1 - 0.4 10.4 12.2 0.12 12.1 5.3 2.0 1 1 0 2 2 2 0 Cor1/Xlr/Xmr conserved region Uds1 PF15456.1 CDF90555.1 - 0.95 9.4 9.7 2.2 8.3 1.6 2.5 1 1 1 2 2 2 0 Up-regulated During Septation H-kinase_dim PF02895.9 CDF90555.1 - 1.1 9.6 4.6 9.4 6.6 0.7 2.5 1 1 1 2 2 2 0 Signal transducing histidine kinase, homodimeric domain TPR_MLP1_2 PF07926.7 CDF90555.1 - 1.3 8.7 11.5 4.6 7.0 1.0 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein IncA PF04156.9 CDF90555.1 - 1.7 8.1 14.9 4.6 6.7 10.3 1.8 1 1 0 1 1 1 0 IncA protein GAS PF13851.1 CDF90555.1 - 2.1 7.5 12.7 1.8 7.7 2.4 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding FliJ PF02050.11 CDF90555.1 - 3.6 7.6 16.8 0.84 9.7 5.5 2.5 1 1 2 3 3 3 0 Flagellar FliJ protein Med2 PF11214.3 CDF90555.1 - 5.2 7.1 7.5 4.6 7.3 1.1 2.2 1 1 1 2 2 2 0 Mediator complex subunit 2 DUF904 PF06005.7 CDF90555.1 - 7.5 6.9 8.8 2.6 8.3 1.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF904) WD40 PF00400.27 CDF90556.1 - 3.7e-25 86.8 16.5 7.9e-06 25.5 0.2 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat PQQ_3 PF13570.1 CDF90556.1 - 0.069 13.4 0.2 6.8 7.1 0.2 3.2 3 0 0 3 3 3 0 PQQ-like domain zf-RING_2 PF13639.1 CDF90557.1 - 3.2e-12 46.0 4.0 1e-10 41.2 0.8 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.1 CDF90557.1 - 1e-07 31.8 4.9 3e-06 27.1 1.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CDF90557.1 - 2e-07 30.5 3.0 1.4e-06 27.8 0.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.2 CDF90557.1 - 1e-06 28.7 0.7 2.9e-05 24.0 0.1 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger zf-RING_5 PF14634.1 CDF90557.1 - 4.8e-06 26.2 2.8 0.00012 21.6 0.2 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 CDF90557.1 - 1.1e-05 24.9 1.9 2.6e-05 23.8 0.2 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.20 CDF90557.1 - 1.3e-05 24.7 3.1 0.0001 21.8 0.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.1 CDF90557.1 - 2.5e-05 24.0 0.9 2.5e-05 24.0 0.6 1.8 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.1 CDF90557.1 - 0.0048 16.3 0.2 0.01 15.3 0.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-Apc11 PF12861.2 CDF90557.1 - 0.11 12.3 2.0 0.1 12.4 0.4 1.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 CDF90557.1 - 2.3 7.8 5.9 0.48 10.0 1.0 1.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain tRNA-synt_1c PF00749.16 CDF90558.1 - 1.6e-111 372.0 0.0 2e-111 371.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1b PF00579.20 CDF90558.1 - 0.088 11.9 0.1 0.39 9.7 0.0 2.0 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) DUF775 PF05603.7 CDF90559.1 - 2e-60 203.7 0.1 2.3e-60 203.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) Latrotoxin_C PF15658.1 CDF90559.1 - 0.094 12.5 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Latrotoxin C-terminal domain DUF4411 PF14367.1 CDF90560.1 - 0.017 14.8 1.8 0.7 9.5 0.0 3.1 2 2 2 4 4 4 0 Domain of unknown function (DUF4411) DUF3322 PF11795.3 CDF90560.1 - 0.045 13.3 0.1 0.37 10.4 0.1 2.5 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) MA-Mit PF09245.5 CDF90560.1 - 0.2 10.8 5.5 0.027 13.7 0.6 1.8 2 0 0 2 2 2 0 Mycoplasma arthritidis-derived mitogen Cys_Met_Meta_PP PF01053.15 CDF90561.1 - 4.9e-143 476.0 0.1 5.6e-143 475.8 0.1 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Met_gamma_lyase PF06838.6 CDF90561.1 - 2.7e-05 22.6 0.0 4.2e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase Aminotran_1_2 PF00155.16 CDF90561.1 - 4.1e-05 22.7 0.1 8.1e-05 21.7 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 CDF90561.1 - 0.0033 16.2 0.1 0.0096 14.6 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 CDF90561.1 - 0.06 12.3 0.0 0.15 11.0 0.0 1.6 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 CDF90561.1 - 0.088 11.9 0.0 0.23 10.5 0.0 1.6 2 0 0 2 2 2 0 Beta-eliminating lyase Ribosomal_60s PF00428.14 CDF90562.1 - 7.4e-26 90.3 10.6 8.6e-26 90.1 7.3 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein KfrA_N PF11740.3 CDF90562.1 - 0.0027 18.1 1.1 0.0034 17.8 0.8 1.1 1 0 0 1 1 1 1 Plasmid replication region DNA-binding N-term Sugar-bind PF04198.8 CDF90562.1 - 0.093 11.6 0.1 0.11 11.3 0.1 1.2 1 0 0 1 1 1 0 Putative sugar-binding domain Ribosomal_S19 PF00203.16 CDF90563.1 - 4.6e-31 106.2 0.1 7.2e-31 105.6 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S19 RRM_1 PF00076.17 CDF90564.1 - 1.1e-16 60.1 0.4 8.4e-13 47.7 0.0 3.9 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF90564.1 - 1.1e-11 44.5 0.2 2.8e-09 36.8 0.0 3.2 2 1 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF90564.1 - 4.7e-07 29.5 0.1 0.0071 16.1 0.0 2.9 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spo7_2_N PF15407.1 CDF90564.1 - 0.11 12.0 0.5 0.45 10.0 0.0 2.3 3 0 0 3 3 3 0 Sporulation protein family 7 CDRT4 PF15213.1 CDF90564.1 - 0.31 11.1 2.9 1.6 8.8 2.0 2.2 1 0 0 1 1 1 0 CMT1A duplicated region transcript 4 protein LMBR1 PF04791.11 CDF90564.1 - 3.4 6.1 4.1 5 5.5 2.8 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein YqzL PF14006.1 CDF90564.1 - 5.5 7.2 0.0 5.5 7.2 0.0 4.3 3 1 0 3 3 3 0 YqzL-like protein Peptidase_U57 PF05582.7 CDF90565.1 - 0.014 14.3 6.3 0.019 13.9 4.4 1.3 1 0 0 1 1 1 0 YabG peptidase U57 HsdM_N PF12161.3 CDF90565.1 - 0.023 15.1 1.7 0.034 14.5 1.2 1.3 1 0 0 1 1 1 0 HsdM N-terminal domain Suf PF05843.9 CDF90565.1 - 0.039 13.7 12.4 0.043 13.5 8.6 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) SprA-related PF12118.3 CDF90565.1 - 0.046 13.0 20.9 0.052 12.8 14.5 1.2 1 0 0 1 1 1 0 SprA-related family OmpH PF03938.9 CDF90565.1 - 0.087 12.7 25.4 0.11 12.3 17.6 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Nop53 PF07767.6 CDF90565.1 - 0.11 11.4 17.9 0.14 11.1 12.4 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) PAT1 PF09770.4 CDF90565.1 - 0.17 10.1 32.0 0.17 10.0 22.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MRP-S31 PF15433.1 CDF90565.1 - 0.31 10.4 16.6 0.41 10.0 11.5 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 DUF775 PF05603.7 CDF90565.1 - 0.77 9.2 12.1 1.1 8.7 8.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF775) FHIPEP PF00771.15 CDF90565.1 - 1.5 7.0 10.5 1.9 6.7 7.3 1.1 1 0 0 1 1 1 0 FHIPEP family AIF_C PF14721.1 CDF90565.1 - 2.1 8.6 7.2 4 7.6 5.0 1.6 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term AAA_23 PF13476.1 CDF90565.1 - 2.4 8.4 16.1 2.9 8.1 11.2 1.2 1 0 0 1 1 1 0 AAA domain APG6 PF04111.7 CDF90565.1 - 6.4 5.7 20.9 8.5 5.3 14.5 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 FAM60A PF15396.1 CDF90565.1 - 7 6.3 10.6 9.5 5.9 7.3 1.2 1 0 0 1 1 1 0 Protein Family FAM60A YjgP_YjgQ PF03739.9 CDF90565.1 - 8.7 4.9 8.1 10 4.7 5.6 1.1 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family DUF4175 PF13779.1 CDF90565.1 - 8.7 3.8 43.3 6.2 4.3 28.9 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) Exo_endo_phos PF03372.18 CDF90566.1 - 7.1e-17 62.1 0.0 8.6e-17 61.8 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Herpes_UL52 PF03121.10 CDF90566.1 - 3.1 7.6 4.9 0.39 10.4 0.3 1.9 2 0 0 2 2 2 0 Herpesviridae UL52/UL70 DNA primase HEAT PF02985.17 CDF90567.1 - 1.6e-35 117.9 29.4 0.0024 17.7 0.0 13.2 14 0 0 14 14 14 9 HEAT repeat HEAT_2 PF13646.1 CDF90567.1 - 1.3e-28 99.0 3.5 2.4e-08 34.1 0.0 7.2 2 1 6 8 8 8 8 HEAT repeats HEAT_EZ PF13513.1 CDF90567.1 - 2.7e-09 37.2 11.8 2.4 8.7 0.0 9.0 9 2 1 10 10 10 3 HEAT-like repeat Vac14_Fab1_bd PF12755.2 CDF90567.1 - 4.1e-09 36.7 8.2 0.47 10.8 0.2 7.6 4 2 4 8 8 8 4 Vacuolar 14 Fab1-binding region Ecm29 PF13001.2 CDF90567.1 - 0.0084 14.6 5.5 0.17 10.3 0.1 3.0 3 0 0 3 3 3 2 Proteasome stabiliser Ovate PF04844.8 CDF90567.1 - 0.072 12.8 1.2 1.1 9.1 0.0 2.8 2 1 1 3 3 3 0 Transcriptional repressor, ovate ADP_PFK_GK PF04587.10 CDF90567.1 - 0.075 11.2 1.4 0.14 10.3 0.4 1.8 2 0 0 2 2 2 0 ADP-specific Phosphofructokinase/Glucokinase conserved region DUF2435 PF10363.4 CDF90567.1 - 0.12 12.3 9.6 1.6 8.6 0.4 4.4 4 1 2 6 6 6 0 Protein of unknown function (DUF2435) RPA_interact_C PF14768.1 CDF90568.1 - 0.041 14.2 1.0 0.14 12.5 0.0 2.2 3 0 0 3 3 3 0 Replication protein A interacting C-terminal Pkinase PF00069.20 CDF90569.1 - 1.1e-61 208.3 0.0 1.8e-61 207.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF90569.1 - 6.5e-21 74.5 0.0 1.2e-20 73.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF90569.1 - 1.2e-11 44.1 0.0 2.1e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PAS_9 PF13426.1 CDF90569.1 - 0.00017 21.9 0.0 0.36 11.2 0.0 2.7 2 0 0 2 2 2 2 PAS domain Kdo PF06293.9 CDF90569.1 - 0.0047 16.0 0.0 0.012 14.6 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family PAS_4 PF08448.5 CDF90569.1 - 0.0048 16.9 0.0 0.026 14.5 0.0 2.2 3 0 0 3 3 3 1 PAS fold RIO1 PF01163.17 CDF90569.1 - 0.008 15.5 0.1 0.018 14.4 0.0 1.5 1 0 0 1 1 1 1 RIO1 family APH PF01636.18 CDF90569.1 - 0.031 13.9 0.0 0.07 12.8 0.0 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF3674 PF12426.3 CDF90571.1 - 0.0011 18.2 0.3 0.0024 17.2 0.2 1.5 1 0 0 1 1 1 1 RNA dependent RNA polymerase DUF4014 PF13198.1 CDF90571.1 - 1.8 9.0 9.8 0.56 10.6 0.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4014) 2OG-FeII_Oxy_2 PF13532.1 CDF90572.1 - 5.7e-21 75.2 0.1 8.6e-21 74.6 0.1 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.15 CDF90572.1 - 0.00078 19.6 0.1 0.0019 18.4 0.1 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Zn_ribbon_recom PF13408.1 CDF90572.1 - 0.73 10.1 9.5 0.057 13.6 2.8 2.1 2 1 0 2 2 2 0 Recombinase zinc beta ribbon domain Herpes_BLLF1 PF05109.8 CDF90573.1 - 0.049 11.6 1.2 1.8 6.4 0.1 2.0 2 0 0 2 2 2 0 Herpes virus major outer envelope glycoprotein (BLLF1) GSH_synth_ATP PF03917.12 CDF90574.1 - 9.6e-127 422.5 0.0 1.2e-126 422.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.10 CDF90574.1 - 2.6e-35 120.6 0.1 5.1e-35 119.7 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic glutathione synthase ATP-grasp_4 PF13535.1 CDF90574.1 - 0.072 12.8 0.0 0.35 10.5 0.0 2.0 2 0 0 2 2 2 0 ATP-grasp domain Med15_fungi PF05397.7 CDF90575.1 - 1.5e-38 131.2 4.2 1.5e-38 131.2 2.9 5.9 4 2 2 6 6 6 1 Mediator complex subunit 15 SNF2_N PF00176.18 CDF90576.1 - 9.2e-71 238.0 0.9 9.2e-71 238.0 0.6 2.1 2 1 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CDF90576.1 - 5.5e-15 55.0 0.0 2.7e-13 49.5 0.0 3.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 CDF90576.1 - 3e-09 36.5 0.0 1.1e-08 34.8 0.0 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.1 CDF90576.1 - 0.0099 16.0 0.0 0.069 13.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain Exo_endo_phos PF03372.18 CDF90578.1 - 3.2e-21 76.3 0.1 5.1e-21 75.7 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.1 CDF90578.1 - 1.6e-19 69.4 20.8 1.6e-10 40.5 1.0 2.6 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.2 CDF90578.1 - 3e-16 58.6 12.9 5.7e-09 35.4 2.8 3.7 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.28 CDF90578.1 - 3.3e-08 32.4 12.4 0.016 15.1 0.0 5.5 5 0 0 5 5 5 3 Leucine Rich Repeat LRR_7 PF13504.1 CDF90578.1 - 7.4e-06 25.3 9.1 0.015 15.3 0.3 4.9 4 0 0 4 4 4 2 Leucine rich repeat LRR_6 PF13516.1 CDF90578.1 - 0.024 14.6 7.1 0.22 11.7 0.0 4.5 4 0 0 4 4 4 0 Leucine Rich repeat Exo_endo_phos_2 PF14529.1 CDF90578.1 - 0.034 13.7 0.0 0.1 12.1 0.0 1.9 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase Nucleoside_tran PF01733.13 CDF90579.1 - 1.8e-60 204.7 30.2 1.3e-43 149.2 5.3 2.5 2 1 1 3 3 3 2 Nucleoside transporter PMT PF02366.13 CDF90580.1 - 2.5e-91 305.4 21.9 2.5e-91 305.4 15.2 2.1 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 CDF90580.1 - 5.2e-26 91.3 0.1 1e-25 90.4 0.0 1.5 1 0 0 1 1 1 1 MIR domain LDB19 PF13002.2 CDF90581.1 - 9.6e-94 312.2 1.5 1.4e-93 311.6 0.3 1.8 2 0 0 2 2 2 1 Arrestin_N terminal like Arrestin_N PF00339.24 CDF90581.1 - 0.0016 18.2 0.4 0.0043 16.8 0.0 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain RasGEF PF00617.14 CDF90582.1 - 2.6e-37 128.3 1.3 8.2e-37 126.7 0.9 1.9 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.15 CDF90582.1 - 6.8e-13 48.6 0.8 6.8e-13 48.6 0.6 3.2 3 0 0 3 3 3 1 RasGEF N-terminal motif Ribosomal_L28e PF01778.12 CDF90583.1 - 1.1e-32 112.8 3.3 1.1e-32 112.8 2.3 1.7 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.9 CDF90583.1 - 7.2e-31 106.2 16.8 7.2e-31 106.2 11.7 2.7 3 0 0 3 3 3 1 Mak16 protein C-terminal region HAD PF12710.2 CDF90584.1 - 1.1e-18 68.0 0.1 3e-18 66.6 0.1 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 CDF90584.1 - 9.2e-18 64.1 0.8 1.7e-17 63.2 0.6 1.4 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 CDF90584.1 - 1.2e-13 51.9 2.0 3.6e-10 40.6 0.9 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like2 PF13246.1 CDF90584.1 - 3.9e-10 39.5 0.0 1.1e-09 38.0 0.0 1.7 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 CDF90584.1 - 0.0016 18.0 0.6 0.012 15.1 0.4 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 CDF90584.1 - 0.065 13.4 0.0 0.17 12.0 0.0 1.7 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Aldedh PF00171.17 CDF90585.1 - 2.3e-12 46.0 0.1 3.5e-09 35.5 0.0 2.3 2 0 0 2 2 2 2 Aldehyde dehydrogenase family Saw1 PF11561.3 CDF90586.1 - 8.5e-62 208.3 7.8 9.9e-62 208.1 5.4 1.0 1 0 0 1 1 1 1 Single strand annealing-weakened 1 Hph PF13694.1 CDF90587.1 - 4.8e-32 111.5 0.6 4.8e-32 111.5 0.4 2.8 3 0 0 3 3 3 1 Sec63/Sec62 complex-interacting family DUF1032 PF06278.6 CDF90587.1 - 0.006 15.1 0.8 0.0093 14.5 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1032) Sec8_exocyst PF04048.9 CDF90587.1 - 1.9 8.1 12.8 0.85 9.2 2.1 2.2 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain Myosin_head PF00063.16 CDF90589.1 - 1.3e-267 889.4 12.4 1.3e-267 889.4 8.6 1.7 2 0 0 2 2 2 1 Myosin head (motor domain) DIL PF01843.14 CDF90589.1 - 1.4e-32 111.6 2.7 1.4e-32 111.6 1.8 3.0 2 0 0 2 2 2 1 DIL domain IQ PF00612.22 CDF90589.1 - 2.4e-08 32.9 20.3 0.0035 16.8 0.3 6.4 7 0 0 7 7 7 3 IQ calmodulin-binding motif Myosin_N PF02736.14 CDF90589.1 - 3.6e-05 23.3 0.3 8.8e-05 22.1 0.2 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain AAA_22 PF13401.1 CDF90589.1 - 0.00036 20.6 0.8 0.0013 18.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.22 CDF90589.1 - 0.12 12.6 0.0 0.12 12.6 0.0 3.7 3 1 0 3 3 3 0 ABC transporter AAA_19 PF13245.1 CDF90589.1 - 0.14 11.9 0.0 0.43 10.3 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain Synaptobrevin PF00957.16 CDF90590.1 - 1.4e-31 107.9 0.7 1.5e-31 107.8 0.5 1.0 1 0 0 1 1 1 1 Synaptobrevin TMEM117 PF15113.1 CDF90590.1 - 0.019 13.6 0.2 0.023 13.3 0.1 1.0 1 0 0 1 1 1 0 TMEM117 protein family PRT_C PF08372.5 CDF90590.1 - 0.072 12.6 0.1 0.085 12.3 0.1 1.2 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal Phospholamban PF04272.9 CDF90590.1 - 0.14 11.5 1.6 0.23 10.9 1.1 1.3 1 0 0 1 1 1 0 Phospholamban DUF3782 PF12644.2 CDF90591.1 - 0.23 11.2 3.0 1.2 8.9 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3782) IncA PF04156.9 CDF90591.1 - 2 7.9 25.7 0.17 11.4 2.9 3.6 3 0 0 3 3 3 0 IncA protein DUF2040 PF09745.4 CDF90592.1 - 9e-07 28.7 7.9 9e-07 28.7 5.5 2.5 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 55 (DUF2040) Paramyx_P_V_C PF03210.8 CDF90592.1 - 0.64 9.8 4.9 0.13 12.1 0.3 2.1 3 0 0 3 3 3 0 Paramyxovirus P/V phosphoprotein C-terminal DNA_pol_A PF00476.15 CDF90593.1 - 2.2e-108 362.3 0.0 3.1e-108 361.8 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family A vATP-synt_E PF01991.13 CDF90594.1 - 6.5e-62 208.3 13.9 7.6e-62 208.1 9.7 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Phlebovirus_NSM PF07246.6 CDF90594.1 - 0.0036 16.5 6.5 0.0036 16.5 4.5 1.4 1 1 0 1 1 1 1 Phlebovirus nonstructural protein NS-M CorA PF01544.13 CDF90595.1 - 1.6e-10 40.5 2.1 2.8e-10 39.6 1.4 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein SKIP_SNW PF02731.10 CDF90597.1 - 3.7e-48 162.9 9.5 3.7e-48 162.9 6.6 2.4 3 0 0 3 3 3 1 SKIP/SNW domain RNase_P_Rpp14 PF01900.14 CDF90598.1 - 1.7e-32 111.4 0.1 2.3e-32 111.0 0.0 1.2 1 0 0 1 1 1 1 Rpp14/Pop5 family tRNA-synt_2c PF01411.14 CDF90599.1 - 4.9e-225 748.0 0.0 8.2e-225 747.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.9 CDF90599.1 - 5.8e-19 67.7 0.3 1.8e-18 66.1 0.2 1.9 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.14 CDF90599.1 - 1.1e-06 28.2 0.8 1.1e-06 28.2 0.5 2.2 2 0 0 2 2 2 1 DHHA1 domain UDP-g_GGTase PF06427.6 CDF90600.1 - 1.1e-08 34.6 0.0 2.8e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Fungal_trans PF04082.13 CDF90601.1 - 2.2e-35 121.8 1.2 4.5e-35 120.7 0.8 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF90601.1 - 7.3e-08 32.1 10.0 2e-07 30.7 6.9 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SWIRM PF04433.12 CDF90602.1 - 6e-13 48.7 0.0 1.2e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 SWIRM domain NT-C2 PF10358.4 CDF90602.1 - 0.047 13.1 0.0 0.075 12.5 0.0 1.3 1 0 0 1 1 1 0 N-terminal C2 in EEIG1 and EHBP1 proteins UQ_con PF00179.21 CDF90603.1 - 1.6e-49 166.9 0.1 1.8e-49 166.7 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CDF90603.1 - 0.00056 19.6 0.0 0.00073 19.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 CDF90603.1 - 0.0039 17.0 0.1 0.0062 16.4 0.1 1.6 1 1 0 1 1 1 1 RWD domain UEV PF05743.8 CDF90603.1 - 0.0064 16.1 0.2 0.011 15.3 0.1 1.4 1 0 0 1 1 1 1 UEV domain PqqD PF05402.7 CDF90603.1 - 0.15 12.0 0.1 0.41 10.7 0.1 1.6 1 1 0 1 1 1 0 Coenzyme PQQ synthesis protein D (PqqD) Mis12 PF05859.7 CDF90604.1 - 1.4e-43 148.1 0.8 1.4e-43 148.1 0.5 2.0 2 1 0 2 2 2 1 Mis12 protein 4HB_MCP_1 PF12729.2 CDF90604.1 - 0.0031 16.8 1.6 0.024 13.9 0.0 2.6 2 1 1 3 3 3 1 Four helix bundle sensory module for signal transduction PRTase_3 PF15610.1 CDF90604.1 - 0.041 12.7 0.1 0.058 12.3 0.0 1.2 1 0 0 1 1 1 0 PRTase ComF-like SHS2_Rpb7-N PF03876.12 CDF90605.1 - 4.9e-12 45.8 0.0 1.3e-11 44.4 0.0 1.7 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RNA_pol_Rpb1_5 PF04998.12 CDF90606.1 - 2.7e-98 328.6 1.1 2.7e-98 328.6 0.8 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 CDF90606.1 - 2.1e-64 216.4 0.6 8.5e-64 214.4 0.1 2.3 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 CDF90606.1 - 2.4e-39 134.6 0.0 1.2e-37 129.1 0.0 3.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 CDF90606.1 - 1.5e-23 82.6 0.8 8.5e-23 80.1 0.1 2.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_1 PF04997.7 CDF90606.1 - 3.5e-20 72.5 4.4 3.5e-20 72.5 3.0 4.5 4 1 0 4 4 4 1 RNA polymerase Rpb1, domain 1 GTP_EFTU PF00009.22 CDF90607.1 - 9e-32 110.0 2.1 1e-31 109.8 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 CDF90607.1 - 2.3e-19 69.2 0.0 6.5e-19 67.8 0.0 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 CDF90607.1 - 2.7e-15 56.2 0.6 1.4e-10 41.0 0.0 3.1 2 0 0 2 2 2 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 CDF90607.1 - 1.4e-06 28.2 1.1 6.2e-06 26.1 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 CDF90607.1 - 0.0028 16.9 0.0 0.037 13.2 0.0 2.7 3 0 0 3 3 3 1 Ferrous iron transport protein B AAA_22 PF13401.1 CDF90607.1 - 0.016 15.3 0.1 0.076 13.1 0.1 2.2 1 1 0 1 1 1 0 AAA domain TGS PF02824.16 CDF90608.1 - 8.7e-22 76.7 0.1 1.7e-21 75.8 0.0 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.18 CDF90608.1 - 9.5e-17 61.0 0.1 2.4e-16 59.7 0.1 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.13 CDF90608.1 - 1.4e-08 34.1 0.0 2.9e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.18 CDF90608.1 - 0.00095 19.0 0.6 0.56 10.0 0.0 2.4 1 1 1 2 2 2 2 Dynamin family ArgK PF03308.11 CDF90608.1 - 0.0074 15.0 0.1 0.014 14.1 0.1 1.4 1 0 0 1 1 1 1 ArgK protein Miro PF08477.8 CDF90608.1 - 0.017 15.6 0.0 0.033 14.6 0.0 1.6 1 0 0 1 1 1 0 Miro-like protein HLH PF00010.21 CDF90610.1 - 3.4e-23 81.1 1.3 1.9e-22 78.6 0.2 2.2 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain ASD1 PF08688.5 CDF90610.1 - 0.025 14.3 0.7 0.042 13.6 0.5 1.3 1 0 0 1 1 1 0 Apx/Shroom domain ASD1 RHH_3 PF12651.2 CDF90610.1 - 0.037 13.7 0.1 0.095 12.4 0.1 1.7 1 0 0 1 1 1 0 Ribbon-helix-helix domain IKI3 PF04762.7 CDF90610.1 - 0.05 11.4 0.0 0.05 11.4 0.0 1.1 1 0 0 1 1 1 0 IKI3 family IMS PF00817.15 CDF90611.1 - 1.1e-29 103.1 2.3 2.1e-29 102.2 0.2 2.4 2 1 0 2 2 2 1 impB/mucB/samB family BRCT PF00533.21 CDF90611.1 - 1e-09 38.4 0.0 2.8e-09 37.0 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain IMS_C PF11799.3 CDF90611.1 - 6.2e-09 35.8 1.2 1.4e-08 34.7 0.0 2.1 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain DUF4414 PF14377.1 CDF90611.1 - 0.0001 22.1 1.0 0.0001 22.1 0.7 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF4414) PTCB-BRCT PF12738.2 CDF90611.1 - 0.0012 18.6 0.0 0.0023 17.7 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain PK PF00224.16 CDF90612.1 - 1.4e-162 540.2 1.3 1.7e-162 539.9 0.9 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.11 CDF90612.1 - 8.1e-30 102.7 0.0 2.5e-29 101.2 0.0 1.9 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.9 CDF90612.1 - 1.5e-05 23.9 0.6 3.5e-05 22.8 0.1 1.8 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family AA_permease PF00324.16 CDF90613.1 - 5.1e-133 443.8 39.2 6.4e-133 443.5 27.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CDF90613.1 - 1.5e-25 89.6 44.2 2e-25 89.2 30.6 1.1 1 0 0 1 1 1 1 Amino acid permease DUF2665 PF11654.3 CDF90613.1 - 0.19 11.3 4.3 0.21 11.1 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2665) DUF485 PF04341.7 CDF90613.1 - 0.6 9.8 0.0 0.6 9.8 0.0 4.2 3 2 2 5 5 5 0 Protein of unknown function, DUF485 MNE1 PF13762.1 CDF90615.1 - 1.2e-27 96.7 12.7 1.2e-27 96.7 8.8 2.9 3 1 1 4 4 4 1 Mitochondrial splicing apparatus component Saccharop_dh_N PF04455.7 CDF90617.1 - 0.092 12.8 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 LOR/SDH bifunctional enzyme conserved region SOG2 PF10428.4 CDF90618.1 - 2.4e-116 389.0 7.6 2.4e-116 389.0 5.3 1.8 2 0 0 2 2 2 1 RAM signalling pathway protein LRR_4 PF12799.2 CDF90618.1 - 1.9e-17 62.4 14.8 4.5e-10 38.9 0.2 4.1 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CDF90618.1 - 2e-16 59.4 11.0 1.1e-10 41.1 0.7 2.9 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.28 CDF90618.1 - 4.1e-10 38.2 12.5 0.0084 16.0 0.2 6.1 4 1 0 4 4 4 4 Leucine Rich Repeat LRR_7 PF13504.1 CDF90618.1 - 2.8e-05 23.6 9.9 0.99 9.8 0.0 5.7 5 0 0 5 5 5 3 Leucine rich repeat SpecificRecomb PF10136.4 CDF90618.1 - 0.0044 15.1 0.1 0.008 14.2 0.1 1.3 1 0 0 1 1 1 1 Site-specific recombinase LRR_9 PF14580.1 CDF90618.1 - 0.067 12.7 1.0 0.17 11.4 0.7 1.6 1 0 0 1 1 1 0 Leucine-rich repeat LRR_6 PF13516.1 CDF90618.1 - 0.09 12.8 11.4 0.14 12.3 0.1 5.1 5 0 0 5 5 5 0 Leucine Rich repeat LRR_3 PF07725.7 CDF90618.1 - 0.5 10.2 3.7 16 5.4 0.2 3.0 2 0 0 2 2 2 0 Leucine Rich Repeat BAF1_ABF1 PF04684.8 CDF90618.1 - 7.9 5.1 20.7 17 4.1 14.4 1.5 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Cyto_heme_lyase PF01265.12 CDF90619.1 - 1.5e-69 234.5 0.0 1.8e-69 234.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase Cas_Cmr5 PF09701.5 CDF90620.1 - 0.0075 16.4 3.5 0.9 9.7 0.1 4.1 3 2 1 4 4 4 1 CRISPR-associated protein (Cas_Cmr5) RPAP3_C PF13877.1 CDF90620.1 - 0.02 14.8 0.5 0.58 10.1 0.1 3.0 2 0 0 2 2 2 0 Potential Monad-binding region of RPAP3 Methyltransf_14 PF08484.6 CDF90620.1 - 0.037 13.5 0.0 0.1 12.1 0.0 1.7 1 0 0 1 1 1 0 C-methyltransferase C-terminal domain Cyclin_N PF00134.18 CDF90621.1 - 2.2e-22 78.9 0.2 3.3e-22 78.3 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cupin_8 PF13621.1 CDF90622.1 - 9.9e-52 175.9 0.0 8.1e-50 169.6 0.0 2.2 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.7 CDF90622.1 - 7.2e-06 25.4 0.0 0.00043 19.6 0.0 2.6 2 0 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.17 CDF90622.1 - 0.052 13.7 0.0 0.14 12.3 0.0 1.7 1 0 0 1 1 1 0 JmjC domain, hydroxylase ETF_QO PF05187.8 CDF90624.1 - 1.9e-40 137.2 0.0 3.1e-40 136.5 0.0 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase DAO PF01266.19 CDF90624.1 - 1.5e-10 40.5 0.5 1.6e-05 24.0 0.2 2.7 3 0 0 3 3 3 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 CDF90624.1 - 6.1e-10 38.5 0.2 0.00012 21.0 0.2 2.2 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.12 CDF90624.1 - 2.3e-08 33.3 0.1 0.00049 19.2 0.0 2.2 2 0 0 2 2 2 2 Thi4 family Pyr_redox_3 PF13738.1 CDF90624.1 - 6.1e-07 29.7 0.1 2.6e-06 27.6 0.1 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CDF90624.1 - 2.5e-06 27.3 0.0 7.7e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 CDF90624.1 - 2.9e-05 22.7 0.3 0.00029 19.4 0.2 2.0 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.9 CDF90624.1 - 3.1e-05 23.9 0.1 9.4e-05 22.3 0.1 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 CDF90624.1 - 4.6e-05 22.6 0.1 0.00011 21.3 0.1 1.7 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 CDF90624.1 - 0.00044 19.4 0.0 0.00073 18.7 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.22 CDF90624.1 - 0.00052 20.3 0.1 2.2 8.7 0.0 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 CDF90624.1 - 0.0032 16.1 0.2 0.027 13.0 0.1 2.1 2 0 0 2 2 2 1 Tryptophan halogenase Lycopene_cycl PF05834.7 CDF90624.1 - 0.0051 15.7 0.1 0.0071 15.3 0.1 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_9 PF13454.1 CDF90624.1 - 0.0055 16.4 0.1 0.012 15.4 0.1 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Fer4_7 PF12838.2 CDF90624.1 - 0.016 15.5 0.6 0.043 14.1 0.4 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain GIDA PF01134.17 CDF90624.1 - 0.078 11.8 0.0 0.15 10.9 0.0 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A COPIIcoated_ERV PF07970.7 CDF90626.1 - 3.4e-75 252.4 0.0 4e-75 252.2 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 CDF90626.1 - 3.7e-32 110.1 0.6 8e-32 109.0 0.1 1.7 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) PX PF00787.19 CDF90627.1 - 1.2e-22 79.8 0.0 1.6e-22 79.4 0.0 1.2 1 0 0 1 1 1 1 PX domain CBFD_NFYB_HMF PF00808.18 CDF90628.1 - 1.6e-21 76.0 1.3 2.9e-21 75.3 0.9 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 CDF90628.1 - 1.5e-15 57.0 0.2 2e-15 56.6 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.5 CDF90628.1 - 0.016 14.9 0.2 0.026 14.3 0.1 1.3 1 0 0 1 1 1 0 CENP-S associating Centromere protein X TAFII28 PF04719.9 CDF90628.1 - 0.086 12.6 0.1 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 hTAFII28-like protein conserved region TAF PF02969.12 CDF90628.1 - 0.11 12.3 0.2 0.2 11.6 0.1 1.5 1 1 0 1 1 1 0 TATA box binding protein associated factor (TAF) DUF3453 PF11935.3 CDF90629.1 - 9.2e-66 221.6 0.7 2.2e-65 220.3 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3453) PDEase_I PF00233.14 CDF90631.1 - 1.7e-45 155.6 0.3 1.5e-44 152.5 0.1 2.1 1 1 1 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.17 CDF90631.1 - 0.0029 17.6 0.1 0.01 15.8 0.0 2.0 2 1 0 2 2 2 1 HD domain GCV_H PF01597.14 CDF90632.1 - 4.1e-44 149.1 0.2 5e-44 148.8 0.1 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein BolA PF01722.13 CDF90633.1 - 2.5e-23 81.8 0.3 4.4e-23 81.0 0.2 1.4 1 1 0 1 1 1 1 BolA-like protein BolA PF01722.13 CDF90634.1 - 5e-16 58.4 0.0 6.7e-16 58.0 0.0 1.2 1 0 0 1 1 1 1 BolA-like protein eIF2A PF08662.6 CDF90635.1 - 1e-27 97.1 2.1 8.8e-25 87.5 0.4 4.2 2 2 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.17 CDF90635.1 - 2.7e-09 36.5 0.2 6.5e-09 35.3 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF90635.1 - 2.4e-06 27.4 0.4 7.8e-06 25.7 0.1 2.0 2 0 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF90635.1 - 0.00016 21.4 0.1 0.00048 19.9 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.27 CDF90635.1 - 0.094 12.6 4.0 37 4.4 0.2 5.4 5 0 0 5 5 5 0 WD domain, G-beta repeat Mto2_bdg PF12808.2 CDF90636.1 - 4.6e-06 26.6 5.7 4.6e-06 26.6 3.9 4.9 4 0 0 4 4 4 1 Micro-tubular organiser Mto1 C-term Mto2-binding region bZIP_2 PF07716.10 CDF90636.1 - 0.012 15.3 2.8 0.012 15.3 2.0 6.5 6 1 1 7 7 7 0 Basic region leucine zipper bZIP_1 PF00170.16 CDF90636.1 - 0.017 15.0 2.3 0.017 15.0 1.6 7.3 8 1 1 9 9 9 0 bZIP transcription factor MbeD_MobD PF04899.7 CDF90636.1 - 9.3 6.2 12.5 0.77 9.7 1.1 3.9 3 0 0 3 3 3 0 MbeD/MobD like Proteasome PF00227.21 CDF90637.1 - 2.3e-51 173.8 0.0 2.9e-51 173.4 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 CDF90637.1 - 9.7e-12 43.9 0.0 9.7e-12 43.9 0.0 2.1 3 0 0 3 3 3 1 Proteasome subunit A N-terminal signature Miro PF08477.8 CDF90638.1 - 1.3e-43 148.2 0.0 8.4e-22 77.9 0.0 2.5 2 0 0 2 2 2 2 Miro-like protein EF_assoc_1 PF08355.7 CDF90638.1 - 8.3e-29 98.7 0.6 1.5e-28 97.8 0.4 1.5 1 0 0 1 1 1 1 EF hand associated EF_assoc_2 PF08356.7 CDF90638.1 - 2.1e-28 97.9 0.0 5.9e-28 96.4 0.0 1.8 1 0 0 1 1 1 1 EF hand associated Ras PF00071.17 CDF90638.1 - 2.3e-26 92.0 0.0 2.2e-13 49.9 0.0 2.5 2 1 0 2 2 2 2 Ras family Arf PF00025.16 CDF90638.1 - 1.7e-09 37.1 0.0 1.5e-06 27.5 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.18 CDF90638.1 - 1.8e-08 34.3 0.0 0.0015 18.4 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_7 PF13499.1 CDF90638.1 - 1.3e-05 25.2 0.6 0.2 11.8 0.1 3.0 3 0 0 3 3 2 2 EF-hand domain pair EF-hand_1 PF00036.27 CDF90638.1 - 2.9e-05 23.0 3.5 0.18 11.1 0.6 3.5 2 0 0 2 2 2 2 EF hand Dynamin_N PF00350.18 CDF90638.1 - 6.8e-05 22.7 0.5 0.013 15.3 0.0 2.5 2 0 0 2 2 2 1 Dynamin family GTP_EFTU PF00009.22 CDF90638.1 - 0.00012 21.6 0.1 1.4 8.3 0.0 3.9 4 0 0 4 4 4 1 Elongation factor Tu GTP binding domain AAA_29 PF13555.1 CDF90638.1 - 0.00014 21.3 0.1 0.43 10.1 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain MobB PF03205.9 CDF90638.1 - 0.00018 21.2 0.4 0.41 10.3 0.1 2.6 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B Gtr1_RagA PF04670.7 CDF90638.1 - 0.00028 20.1 0.1 0.0013 17.8 0.0 1.9 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region DUF258 PF03193.11 CDF90638.1 - 0.0025 16.9 0.0 0.046 12.9 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_24 PF13479.1 CDF90638.1 - 0.0029 17.2 0.1 0.47 10.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain Septin PF00735.13 CDF90638.1 - 0.0036 16.3 0.0 0.19 10.7 0.0 2.2 2 0 0 2 2 2 1 Septin AAA_16 PF13191.1 CDF90638.1 - 0.0052 16.7 0.0 4.7 7.1 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.22 CDF90638.1 - 0.0064 16.7 0.1 1.3 9.3 0.0 2.4 2 0 0 2 2 2 1 ABC transporter EF-hand_6 PF13405.1 CDF90638.1 - 0.0094 15.7 6.2 1.5 8.8 1.1 3.2 2 0 0 2 2 2 2 EF-hand domain AAA_22 PF13401.1 CDF90638.1 - 0.0098 16.0 0.0 1.5 8.9 0.0 2.6 2 1 0 2 2 2 1 AAA domain EF-hand_8 PF13833.1 CDF90638.1 - 0.018 14.6 1.6 4.3 7.0 0.6 2.7 2 0 0 2 2 2 0 EF-hand domain pair AAA_10 PF12846.2 CDF90638.1 - 0.035 13.5 0.0 7.4 5.9 0.0 2.4 2 0 0 2 2 2 0 AAA-like domain FeoB_N PF02421.13 CDF90638.1 - 0.039 13.2 0.0 9.3 5.5 0.0 3.3 2 1 0 2 2 2 0 Ferrous iron transport protein B AAA_18 PF13238.1 CDF90638.1 - 0.081 13.2 1.3 4.6 7.5 0.0 3.3 2 2 1 3 3 3 0 AAA domain NACHT PF05729.7 CDF90638.1 - 0.083 12.5 0.0 2.3 7.8 0.0 2.5 2 0 0 2 2 2 0 NACHT domain RNA_helicase PF00910.17 CDF90638.1 - 0.11 12.6 0.0 3.2 7.9 0.0 2.5 2 0 0 2 2 2 0 RNA helicase DAP3 PF10236.4 CDF90638.1 - 0.11 11.4 0.3 0.43 9.4 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_25 PF13481.1 CDF90638.1 - 0.15 11.4 0.0 4.9 6.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.13 CDF90638.1 - 0.18 11.2 0.0 17 4.7 0.0 2.8 3 0 0 3 3 3 0 FtsK/SpoIIIE family EF-hand_5 PF13202.1 CDF90638.1 - 0.83 9.1 7.0 0.5 9.7 1.0 3.0 2 0 0 2 2 2 0 EF hand DLH PF01738.13 CDF90639.1 - 2.2e-32 112.1 0.1 2.6e-32 111.9 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 CDF90639.1 - 5.2e-06 26.2 0.0 6.6e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Zn_clus PF00172.13 CDF90640.1 - 1.3e-10 40.9 11.3 2.4e-10 40.1 7.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TRP PF06011.7 CDF90641.1 - 3.1e-161 536.8 30.4 4.5e-161 536.3 21.0 1.2 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.1 CDF90641.1 - 1.2e-42 145.2 2.1 2.1e-42 144.5 1.5 1.4 1 0 0 1 1 1 1 ML-like domain AMP-binding PF00501.23 CDF90642.1 - 1.3e-89 300.5 0.1 1.6e-89 300.2 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 CDF90642.1 - 6.1e-19 68.7 0.0 3e-18 66.5 0.0 2.2 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain GNAT_acetyltran PF12746.2 CDF90642.1 - 0.064 12.0 0.0 0.11 11.2 0.0 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase CH PF00307.26 CDF90643.1 - 1e-09 38.3 0.0 1.4e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain Peroxin-22 PF12827.2 CDF90644.1 - 1.1e-23 83.2 0.0 1.3e-23 82.9 0.0 1.1 1 0 0 1 1 1 1 Peroxisomal biogenesis protein family Rad1 PF02144.11 CDF90645.1 - 7.7e-66 221.6 0.9 9.6e-66 221.3 0.6 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Ribosomal_L7Ae PF01248.21 CDF90646.1 - 1.8e-21 75.4 0.3 2.3e-21 75.1 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF1269 PF06897.7 CDF90646.1 - 0.0014 18.6 0.2 0.0024 17.8 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1269) Kelch_3 PF13415.1 CDF90647.1 - 4.9e-09 36.1 2.0 0.019 15.1 0.0 5.0 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.10 CDF90647.1 - 1.5e-08 34.0 11.7 0.011 15.4 0.2 6.2 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.1 CDF90647.1 - 7.2e-08 32.2 11.0 0.0037 17.3 0.0 5.9 6 0 0 6 6 6 2 Kelch motif Kelch_5 PF13854.1 CDF90647.1 - 2.3e-07 30.5 4.6 0.74 9.8 0.0 6.3 6 0 0 6 6 6 2 Kelch motif Kelch_4 PF13418.1 CDF90647.1 - 5.6e-06 26.0 20.2 0.014 15.1 0.0 5.7 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.20 CDF90647.1 - 0.00025 20.5 13.1 0.15 11.6 0.1 5.4 5 0 0 5 5 5 2 Kelch motif TSA PF03249.8 CDF90648.1 - 1 7.8 5.1 1.5 7.2 3.5 1.3 1 0 0 1 1 1 0 Type specific antigen LRR_4 PF12799.2 CDF90649.1 - 7.7e-18 63.6 20.7 3.8e-07 29.5 0.7 6.9 7 1 0 7 7 7 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CDF90649.1 - 4.9e-16 58.2 25.6 1.2e-07 31.3 1.5 6.1 5 2 1 7 7 7 4 Leucine rich repeat LRR_1 PF00560.28 CDF90649.1 - 7.1e-11 40.5 26.7 0.079 13.0 0.4 10.8 9 1 1 10 10 10 2 Leucine Rich Repeat LRR_6 PF13516.1 CDF90649.1 - 1.9e-06 27.3 20.3 0.45 10.7 0.1 9.5 9 1 1 10 10 10 1 Leucine Rich repeat LRR_9 PF14580.1 CDF90649.1 - 7.3e-06 25.6 1.4 0.96 8.9 0.0 3.8 3 1 0 3 3 3 3 Leucine-rich repeat LRR_7 PF13504.1 CDF90649.1 - 7.5e-05 22.3 34.7 0.27 11.6 0.1 11.4 11 1 1 12 12 12 2 Leucine rich repeat DUF2673 PF10880.3 CDF90649.1 - 0.092 12.8 0.8 0.28 11.2 0.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2673) DUF4637 PF15470.1 CDF90649.1 - 2.6 7.6 7.9 7.3 6.1 3.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) Aldedh PF00171.17 CDF90650.1 - 2.2e-182 606.5 0.0 2.5e-182 606.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 CDF90650.1 - 0.00021 20.1 0.0 0.00059 18.6 0.0 1.6 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) Calreticulin PF00262.13 CDF90651.1 - 9.3e-121 402.9 3.1 1.1e-120 402.6 2.1 1.1 1 0 0 1 1 1 1 Calreticulin family Alb1 PF09135.6 CDF90652.1 - 1.6e-23 83.4 13.3 1.6e-23 83.4 9.2 1.4 2 0 0 2 2 2 1 Alb1 DUF3595 PF12166.3 CDF90652.1 - 0.17 10.7 0.7 0.19 10.4 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3595) ADH_N PF08240.7 CDF90653.1 - 1.6e-31 108.3 3.0 2.8e-31 107.5 2.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CDF90653.1 - 3.1e-19 68.7 0.1 6e-19 67.8 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Pyr_redox PF00070.22 CDF90653.1 - 0.0085 16.4 0.2 0.092 13.1 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.14 CDF90653.1 - 0.011 14.8 0.1 0.057 12.5 0.0 2.0 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 CDF90653.1 - 0.066 13.3 0.2 0.11 12.5 0.2 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox_3 PF13738.1 CDF90653.1 - 0.12 12.4 0.1 0.16 11.9 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.1 CDF90653.1 - 0.13 12.5 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding F420_oxidored PF03807.12 CDF90653.1 - 0.17 12.3 0.5 1.8 9.0 0.2 2.2 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent ELFV_dehydrog PF00208.16 CDF90654.1 - 7e-80 268.1 2.4 8.4e-80 267.8 1.7 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.13 CDF90654.1 - 5.6e-46 155.3 0.0 1.2e-45 154.3 0.0 1.6 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain DUF373 PF04123.8 CDF90654.1 - 0.021 13.8 0.1 0.035 13.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) NAD_binding_7 PF13241.1 CDF90654.1 - 0.082 13.1 0.1 0.2 11.9 0.1 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding Bac_luciferase PF00296.15 CDF90657.1 - 1.9e-49 168.4 0.0 3e-49 167.8 0.0 1.2 1 0 0 1 1 1 1 Luciferase-like monooxygenase MFS_1 PF07690.11 CDF90658.1 - 9.8e-32 110.0 27.6 1.1e-31 109.8 18.5 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Fungal_trans_2 PF11951.3 CDF90659.1 - 1.6e-07 30.2 0.5 4.7e-07 28.7 0.3 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF90659.1 - 1.1e-06 28.3 12.8 3e-06 27.0 8.9 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aldolase_II PF00596.16 CDF90660.1 - 9e-47 159.0 0.0 1.1e-46 158.7 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain S-methyl_trans PF02574.11 CDF90661.1 - 3.7e-90 302.3 0.0 4.2e-90 302.1 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase AA_permease PF00324.16 CDF90662.1 - 3.9e-110 368.4 41.6 4.4e-110 368.2 28.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CDF90662.1 - 3.1e-39 134.7 45.7 3.5e-39 134.5 31.7 1.0 1 0 0 1 1 1 1 Amino acid permease Amidohydro_1 PF01979.15 CDF90663.1 - 4e-28 99.0 0.7 6.1e-28 98.4 0.5 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 CDF90663.1 - 2e-16 60.8 0.0 8.1e-15 55.5 0.0 2.2 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_5 PF13594.1 CDF90663.1 - 1.1e-12 47.5 0.1 4.2e-12 45.7 0.0 2.0 2 0 0 2 2 2 1 Amidohydrolase Amidohydro_3 PF07969.6 CDF90663.1 - 5e-10 39.1 1.1 1.2e-06 28.0 0.0 2.2 1 1 1 2 2 2 2 Amidohydrolase family adh_short PF00106.20 CDF90664.1 - 7.6e-05 22.6 0.4 0.00031 20.7 0.3 1.8 1 1 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.1 CDF90664.1 - 0.00024 21.1 0.0 0.00032 20.7 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding KR PF08659.5 CDF90664.1 - 0.031 13.9 0.8 0.36 10.4 0.6 2.1 1 1 0 1 1 1 0 KR domain Epimerase PF01370.16 CDF90664.1 - 0.045 13.1 0.0 0.07 12.5 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family His_Phos_2 PF00328.17 CDF90665.1 - 9e-47 160.0 0.0 1.1e-46 159.8 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PDR_CDR PF06422.7 CDF90667.1 - 3.3e-05 23.4 0.3 5.3e-05 22.8 0.2 1.3 1 0 0 1 1 1 1 CDR ABC transporter ABC2_membrane PF01061.19 CDF90667.1 - 0.019 14.0 3.5 0.1 11.7 0.1 2.1 2 0 0 2 2 2 0 ABC-2 type transporter Exo5 PF09810.4 CDF90668.1 - 8.6e-29 100.7 2.5 1.8e-27 96.4 1.7 2.6 1 1 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease DUF3271 PF11675.3 CDF90668.1 - 0.039 13.0 2.0 0.054 12.6 0.1 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3271) PDDEXK_1 PF12705.2 CDF90668.1 - 0.046 13.1 1.0 0.3 10.4 0.7 2.3 1 1 0 1 1 1 0 PD-(D/E)XK nuclease superfamily Glutaredoxin PF00462.19 CDF90669.1 - 3.6e-18 65.3 0.0 6.3e-18 64.5 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Amidase PF01425.16 CDF90670.1 - 5.4e-91 305.6 0.0 7.4e-91 305.1 0.0 1.2 1 0 0 1 1 1 1 Amidase AHS2 PF02626.10 CDF90670.1 - 1.4e-83 280.3 0.0 2.5e-83 279.5 0.0 1.4 1 0 0 1 1 1 1 Allophanate hydrolase subunit 2 CPSase_L_D2 PF02786.12 CDF90670.1 - 4.2e-63 212.4 0.0 1e-62 211.1 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain AHS1 PF02682.11 CDF90670.1 - 1.6e-43 148.5 0.0 3.1e-43 147.6 0.0 1.4 1 0 0 1 1 1 1 Allophanate hydrolase subunit 1 CPSase_L_chain PF00289.17 CDF90670.1 - 6e-37 126.1 0.0 1.7e-36 124.6 0.0 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 CDF90670.1 - 1.5e-33 114.9 0.0 3.4e-33 113.8 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain ATP-grasp_4 PF13535.1 CDF90670.1 - 4.1e-19 69.0 0.0 1e-18 67.7 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl PF00364.17 CDF90670.1 - 2.2e-18 65.6 0.7 7.5e-18 63.9 0.5 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.8 CDF90670.1 - 5.6e-11 42.2 0.0 1.1e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 CDF90670.1 - 2.3e-05 23.7 0.1 4.7e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.9 CDF90670.1 - 0.0001 22.2 0.0 0.0002 21.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.6 CDF90670.1 - 0.00049 19.6 0.0 0.0027 17.1 0.0 2.1 1 1 0 1 1 1 1 RimK-like ATP-grasp domain RnfC_N PF13375.1 CDF90670.1 - 0.0057 16.3 0.0 0.016 14.8 0.0 1.7 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain HlyD_3 PF13437.1 CDF90670.1 - 0.019 15.3 0.2 0.12 12.7 0.2 2.4 2 0 0 2 2 2 0 HlyD family secretion protein ATP-grasp_5 PF13549.1 CDF90670.1 - 0.054 12.6 0.0 0.11 11.6 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain FTR1 PF03239.9 CDF90671.1 - 4.5e-99 331.2 4.5 5.3e-99 331.0 3.1 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family OppC_N PF12911.2 CDF90671.1 - 0.51 9.7 5.3 3.2 7.1 0.1 3.5 4 0 0 4 4 4 0 N-terminal TM domain of oligopeptide transport permease C CorA PF01544.13 CDF90672.1 - 0.0087 15.1 12.1 0.019 14.0 8.4 1.6 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Glyco_transf_15 PF01793.11 CDF90673.1 - 1.5e-137 457.9 6.6 2e-137 457.6 4.6 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Abhydrolase_6 PF12697.2 CDF90674.1 - 1.1e-27 97.4 0.0 1.4e-27 97.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CDF90674.1 - 7.7e-19 67.8 0.0 2e-18 66.5 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDF90674.1 - 1.8e-17 63.6 0.0 4.7e-17 62.3 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF2305 PF10230.4 CDF90674.1 - 5.5e-08 32.5 0.2 2.1e-07 30.6 0.1 1.9 1 1 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) PGAP1 PF07819.8 CDF90674.1 - 1.5e-06 27.9 0.4 1.4e-05 24.7 0.2 2.3 2 1 0 2 2 2 1 PGAP1-like protein Ser_hydrolase PF06821.8 CDF90674.1 - 4.7e-06 26.3 0.0 1e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Serine hydrolase Thioesterase PF00975.15 CDF90674.1 - 0.00032 20.9 0.0 0.00048 20.4 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Hydrolase_4 PF12146.3 CDF90674.1 - 0.0006 19.6 0.0 0.0013 18.4 0.0 1.7 1 0 0 1 1 1 1 Putative lysophospholipase LCAT PF02450.10 CDF90674.1 - 0.0046 15.9 0.1 0.013 14.4 0.1 1.6 2 0 0 2 2 2 1 Lecithin:cholesterol acyltransferase DUF1749 PF08538.5 CDF90674.1 - 0.008 15.1 0.0 0.12 11.2 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1749) Abhydrolase_3 PF07859.8 CDF90674.1 - 0.0082 15.7 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF676 PF05057.9 CDF90674.1 - 0.014 14.7 0.1 0.067 12.4 0.1 2.0 1 1 0 1 1 1 0 Putative serine esterase (DUF676) DUF900 PF05990.7 CDF90674.1 - 0.019 14.3 0.1 0.15 11.3 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) Lipase_3 PF01764.20 CDF90674.1 - 0.019 14.5 0.0 0.03 13.9 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF915 PF06028.6 CDF90674.1 - 0.027 13.5 0.0 0.49 9.4 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Peptidase_S9 PF00326.16 CDF90674.1 - 0.031 13.4 0.0 1.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family UPF0227 PF05728.7 CDF90674.1 - 0.041 13.5 0.0 0.084 12.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) DUF3530 PF12048.3 CDF90674.1 - 0.079 11.9 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) NAD_binding_6 PF08030.7 CDF90675.1 - 3.7e-22 78.8 0.1 8.3e-22 77.7 0.0 1.7 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 CDF90675.1 - 1.3e-16 60.8 18.6 1.4e-15 57.4 10.5 2.5 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 CDF90675.1 - 7.1e-16 57.9 0.0 1.7e-15 56.7 0.0 1.7 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.16 CDF90675.1 - 0.034 14.6 0.0 0.98 10.0 0.0 2.5 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain F-box-like PF12937.2 CDF90676.1 - 2.2e-05 24.0 0.3 7.8e-05 22.3 0.0 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.28 CDF90676.1 - 0.0006 19.3 0.8 0.004 16.7 0.0 2.7 3 0 0 3 3 3 1 F-box domain PRANC PF09372.5 CDF90676.1 - 0.073 13.0 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 PRANC domain NIF PF03031.13 CDF90677.1 - 5.9e-41 139.7 0.0 1.1e-40 138.9 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Pro_isomerase PF00160.16 CDF90678.1 - 8.1e-07 29.3 0.1 3.8e-06 27.1 0.0 2.1 2 1 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF809 PF05663.6 CDF90678.1 - 0.96 9.3 4.1 1.7 8.5 2.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF809) POX PF07526.6 CDF90678.1 - 2.1 8.6 6.4 3.7 7.7 4.5 1.3 1 0 0 1 1 1 0 Associated with HOX Pkinase PF00069.20 CDF90679.1 - 2e-35 122.1 0.0 1e-34 119.8 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF90679.1 - 1e-07 31.2 0.0 1.3e-05 24.3 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase RIO1 PF01163.17 CDF90679.1 - 0.078 12.3 0.1 3.2 7.0 0.0 2.2 2 0 0 2 2 2 0 RIO1 family VPS28 PF03997.7 CDF90680.1 - 1e-48 165.4 0.0 1.2e-48 165.2 0.0 1.0 1 0 0 1 1 1 1 VPS28 protein Cytidylate_kin2 PF13189.1 CDF90680.1 - 0.086 12.7 0.2 1.7 8.5 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase-like family T2SE_Nter PF05157.10 CDF90680.1 - 0.11 12.5 0.1 1.2 9.1 0.0 2.3 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein E, N-terminal domain YwqJ-deaminase PF14431.1 CDF90680.1 - 0.14 12.0 0.0 0.3 10.9 0.0 1.6 2 0 0 2 2 2 0 YwqJ-like deaminase Arrestin_C PF02752.17 CDF90681.1 - 0.025 14.6 0.0 0.21 11.6 0.0 2.3 1 1 0 1 1 1 0 Arrestin (or S-antigen), C-terminal domain MCM PF00493.18 CDF90682.1 - 1.1e-134 448.4 0.1 2.4e-133 444.0 0.0 2.1 2 0 0 2 2 2 1 MCM2/3/5 family MCM_N PF14551.1 CDF90682.1 - 3.5e-25 88.8 0.0 2.5e-24 86.0 0.0 2.5 1 1 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.16 CDF90682.1 - 6.3e-08 32.0 0.0 9.7e-06 24.8 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 CDF90682.1 - 1.3e-05 24.9 0.0 9.1e-05 22.2 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase_2 PF13335.1 CDF90682.1 - 2.6e-05 24.5 0.2 0.00016 22.0 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 CDF90682.1 - 0.039 13.4 0.0 0.94 8.9 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain NUP PF06516.6 CDF90683.1 - 4.2e-115 383.8 2.2 6.1e-115 383.3 1.5 1.2 1 0 0 1 1 1 1 Purine nucleoside permease (NUP) WD40 PF00400.27 CDF90684.1 - 2e-36 122.5 16.8 6.8e-07 28.9 0.2 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat PQQ_3 PF13570.1 CDF90684.1 - 0.0019 18.3 0.0 0.65 10.3 0.0 3.7 3 0 0 3 3 3 1 PQQ-like domain DUF3312 PF11768.3 CDF90684.1 - 0.024 12.8 0.0 0.034 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3312) Nup160 PF11715.3 CDF90684.1 - 0.025 12.7 4.5 1 7.4 0.0 2.9 3 1 1 4 4 4 0 Nucleoporin Nup120/160 V_ATPase_I PF01496.14 CDF90685.1 - 4.8e-283 940.6 0.1 5.4e-283 940.5 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF2051 PF09738.4 CDF90685.1 - 0.029 13.6 1.4 0.032 13.5 0.1 1.7 2 0 0 2 2 2 0 Double stranded RNA binding protein (DUF2051) GHMP_kinases_N PF00288.21 CDF90686.1 - 3.9e-21 74.8 0.8 8.4e-21 73.8 0.5 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 CDF90686.1 - 7.7e-07 29.2 0.1 3.5e-06 27.1 0.0 2.1 1 1 1 2 2 2 1 GHMP kinases C terminal Mtc PF03820.12 CDF90687.1 - 5.1e-121 403.0 0.0 5.7e-121 402.8 0.0 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier KdgT PF03812.8 CDF90687.1 - 0.00024 20.3 0.7 0.2 10.7 0.0 2.5 2 1 1 3 3 3 2 2-keto-3-deoxygluconate permease DUF2371 PF10177.4 CDF90687.1 - 0.05 13.4 0.0 0.08 12.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) WD40 PF00400.27 CDF90688.1 - 4.1e-34 115.2 13.7 1.1e-07 31.3 0.0 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat NLE PF08154.7 CDF90688.1 - 8e-24 83.4 0.2 1.4e-23 82.6 0.1 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.3 CDF90688.1 - 9.6e-07 27.3 4.8 0.0081 14.3 0.4 3.6 2 2 1 3 3 3 3 Nucleoporin Nup120/160 DUF3695 PF12494.3 CDF90688.1 - 0.0075 15.9 0.0 2.7 7.7 0.0 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF3695) N2227 PF07942.7 CDF90689.1 - 3.3e-60 203.3 0.0 4.9e-60 202.7 0.0 1.2 1 0 0 1 1 1 1 N2227-like protein Methyltransf_18 PF12847.2 CDF90689.1 - 0.12 13.0 0.0 0.53 10.8 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Tubulin_3 PF14881.1 CDF90690.1 - 1.3e-21 76.9 0.1 2.3e-21 76.0 0.1 1.4 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.4 CDF90690.1 - 7.1e-19 67.9 0.6 1.3e-18 67.1 0.4 1.4 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.20 CDF90690.1 - 0.0002 21.2 0.0 0.021 14.6 0.0 2.4 2 0 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain BRO1 PF03097.13 CDF90691.1 - 2e-83 280.2 8.2 2e-83 280.2 5.7 1.7 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.1 CDF90691.1 - 6.5e-26 90.9 21.6 3.2e-14 52.5 5.6 3.1 4 0 0 4 4 4 2 ALIX V-shaped domain binding to HIV DUF1474 PF07342.6 CDF90691.1 - 0.04 14.1 5.6 3.7 7.8 2.1 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1474) Myb_DNA-binding PF00249.26 CDF90693.1 - 8e-21 73.8 2.3 6.7e-11 42.0 0.2 3.1 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CDF90693.1 - 1.5e-19 69.8 5.7 3e-13 49.6 0.8 3.0 1 1 1 2 2 2 2 Myb-like DNA-binding domain Glycos_transf_3 PF00591.16 CDF90694.1 - 2.1e-81 273.0 0.0 3e-81 272.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.12 CDF90694.1 - 6.4e-13 48.0 0.1 1.5e-12 46.9 0.1 1.7 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain TMF_TATA_bd PF12325.3 CDF90695.1 - 0.0011 18.7 13.2 0.0011 18.7 9.1 8.3 2 2 4 7 7 7 3 TATA element modulatory factor 1 TATA binding ATG16 PF08614.6 CDF90695.1 - 0.0055 16.5 30.9 0.0055 16.5 21.4 6.6 1 1 5 6 6 6 3 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.4 CDF90695.1 - 0.0092 15.8 28.3 0.0092 15.8 19.6 7.3 1 1 6 8 8 8 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Reo_sigmaC PF04582.7 CDF90695.1 - 0.017 14.2 37.5 0.016 14.4 5.6 3.5 3 1 1 4 4 4 0 Reovirus sigma C capsid protein Syntaxin_2 PF14523.1 CDF90696.1 - 0.011 15.7 1.0 0.015 15.2 0.7 1.2 1 0 0 1 1 1 0 Syntaxin-like protein PP_kinase_N PF13089.1 CDF90696.1 - 0.013 15.5 0.2 0.087 12.9 0.0 2.0 2 0 0 2 2 2 0 Polyphosphate kinase N-terminal domain DegS PF05384.6 CDF90696.1 - 0.016 14.4 2.3 0.026 13.7 1.4 1.5 1 1 0 1 1 1 0 Sensor protein DegS COG5 PF10392.4 CDF90696.1 - 0.047 13.6 1.3 0.11 12.5 0.9 1.5 1 1 0 1 1 1 0 Golgi transport complex subunit 5 Rep_2 PF01719.12 CDF90696.1 - 0.075 12.5 2.8 0.087 12.3 2.0 1.1 1 0 0 1 1 1 0 Plasmid replication protein DUF2365 PF10157.4 CDF90696.1 - 0.099 12.5 0.3 0.12 12.2 0.2 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2365) VHS PF00790.14 CDF90697.1 - 6.3e-47 158.7 0.0 3.5e-46 156.3 0.0 2.2 2 1 1 3 3 3 1 VHS domain Alpha_adaptinC2 PF02883.15 CDF90697.1 - 1.8e-19 70.1 0.7 1.8e-19 70.1 0.5 1.9 2 0 0 2 2 2 1 Adaptin C-terminal domain GAT PF03127.9 CDF90697.1 - 1.5e-12 47.3 2.4 4.1e-12 45.9 1.7 1.7 1 0 0 1 1 1 1 GAT domain PrkA PF06798.7 CDF90697.1 - 0.025 13.8 0.8 5.3 6.2 0.0 2.4 2 0 0 2 2 2 0 PrkA serine protein kinase C-terminal domain DUF3783 PF12646.2 CDF90697.1 - 0.053 13.2 1.4 0.13 12.0 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3783) IZUMO PF15005.1 CDF90697.1 - 0.27 11.2 1.2 0.59 10.1 0.8 1.6 1 0 0 1 1 1 0 Izumo sperm-egg fusion HSA PF07529.8 CDF90698.1 - 2.4e-17 62.4 0.5 2.4e-17 62.4 0.4 4.1 4 0 0 4 4 4 1 HSA Myb_DNA-bind_6 PF13921.1 CDF90698.1 - 2.3e-09 37.1 0.4 1.2e-08 34.9 0.2 2.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain BCIP PF13862.1 CDF90699.1 - 2e-50 170.9 0.4 2.7e-50 170.5 0.3 1.2 1 0 0 1 1 1 1 p21-C-terminal region-binding protein SET PF00856.23 CDF90700.1 - 0.012 15.9 0.0 0.028 14.7 0.0 1.6 1 0 0 1 1 1 0 SET domain EMP24_GP25L PF01105.19 CDF90701.1 - 1.6e-43 148.5 0.3 1.8e-43 148.3 0.2 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF4140 PF13600.1 CDF90701.1 - 0.052 13.9 0.1 0.088 13.2 0.1 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) AT_hook PF02178.14 CDF90702.1 - 0.01 15.3 3.1 0.01 15.3 2.1 2.5 2 0 0 2 2 2 0 AT hook motif Cys_Met_Meta_PP PF01053.15 CDF90703.1 - 3.4e-64 216.5 0.0 7.5e-64 215.4 0.0 1.5 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 CDF90703.1 - 4.4e-05 22.4 0.0 8.6e-05 21.4 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.16 CDF90703.1 - 0.023 13.6 0.0 0.039 12.8 0.0 1.5 1 0 0 1 1 1 0 Aminotransferase class I and II Peptidase_M18 PF02127.10 CDF90704.1 - 6.5e-174 578.4 0.0 7.4e-174 578.2 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.9 CDF90704.1 - 1.6e-07 30.4 0.0 9.1e-05 21.3 0.0 2.1 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase Rad60-SLD PF11976.3 CDF90705.1 - 4.4e-23 80.7 1.1 2.9e-22 78.1 1.3 2.1 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like RRM_3 PF08777.6 CDF90705.1 - 0.069 13.0 0.3 1.8 8.4 0.1 2.5 2 0 0 2 2 2 0 RNA binding motif RNA_pol_Rpb1_5 PF04998.12 CDF90706.1 - 2.1e-96 322.4 0.3 3.1e-96 321.8 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.7 CDF90706.1 - 1.5e-80 270.9 0.0 2.8e-80 270.1 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.15 CDF90706.1 - 1.3e-68 230.1 0.1 3.5e-68 228.7 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 CDF90706.1 - 6.5e-40 136.4 0.0 1.9e-39 134.9 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 CDF90706.1 - 1.5e-30 105.0 0.0 4.4e-30 103.6 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 AAA PF00004.24 CDF90707.1 - 2.9e-41 140.7 0.2 8.6e-41 139.2 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 CDF90707.1 - 3.4e-05 23.9 0.1 0.011 15.7 0.0 2.7 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.9 CDF90707.1 - 4e-05 23.6 0.0 0.00018 21.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 CDF90707.1 - 4.3e-05 23.2 0.8 0.00022 20.9 0.1 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 CDF90707.1 - 0.00026 21.1 0.2 0.0074 16.4 0.1 2.6 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 CDF90707.1 - 0.00066 18.7 0.1 0.0015 17.6 0.0 1.6 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_17 PF13207.1 CDF90707.1 - 0.0068 17.2 0.1 0.024 15.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 CDF90707.1 - 0.0072 16.2 0.0 0.017 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain PhoH PF02562.11 CDF90707.1 - 0.0075 15.5 0.2 0.032 13.4 0.1 2.0 2 0 0 2 2 2 1 PhoH-like protein AAA_19 PF13245.1 CDF90707.1 - 0.0085 15.8 0.2 0.024 14.4 0.1 1.7 1 0 0 1 1 1 1 Part of AAA domain IstB_IS21 PF01695.12 CDF90707.1 - 0.0086 15.5 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.16 CDF90707.1 - 0.015 14.5 0.2 0.038 13.1 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.8 CDF90707.1 - 0.015 14.2 0.0 0.029 13.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) BLOC1_2 PF10046.4 CDF90707.1 - 0.02 14.9 0.6 0.077 13.1 0.4 2.0 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AAA_11 PF13086.1 CDF90707.1 - 0.023 14.2 0.1 0.26 10.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.1 CDF90707.1 - 0.029 13.7 0.7 0.19 11.0 0.1 2.2 1 1 1 2 2 2 0 AAA domain AAA_14 PF13173.1 CDF90707.1 - 0.039 13.8 0.0 0.096 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 CDF90707.1 - 0.061 12.9 0.6 0.14 11.7 0.1 1.8 2 0 0 2 2 2 0 AAA domain KaiC PF06745.8 CDF90707.1 - 0.1 11.7 0.6 0.25 10.4 0.0 2.0 3 0 0 3 3 3 0 KaiC RNA_helicase PF00910.17 CDF90707.1 - 0.13 12.4 0.0 0.53 10.4 0.0 2.0 2 0 0 2 2 2 0 RNA helicase WD40 PF00400.27 CDF90708.1 - 4.1e-36 121.5 5.9 5.1e-09 35.6 0.0 6.6 6 1 0 6 6 6 6 WD domain, G-beta repeat NUC153 PF08159.7 CDF90709.1 - 3.6e-12 45.6 0.9 3.6e-12 45.6 0.6 3.3 3 0 0 3 3 3 2 NUC153 domain TLD PF07534.11 CDF90710.1 - 9.2e-28 96.9 0.0 4.1e-26 91.6 0.0 2.3 2 0 0 2 2 2 2 TLD RIO1 PF01163.17 CDF90711.1 - 2.7e-72 242.1 0.1 2.7e-72 242.1 0.1 2.2 2 0 0 2 2 2 1 RIO1 family APH PF01636.18 CDF90711.1 - 0.0025 17.5 0.1 0.11 12.1 0.0 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family CDC45 PF02724.9 CDF90711.1 - 4 5.3 19.7 6.2 4.7 13.6 1.2 1 0 0 1 1 1 0 CDC45-like protein Kei1 PF08552.6 CDF90712.1 - 1.8e-48 164.6 13.3 1.7e-46 158.2 9.2 2.0 1 1 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 Trep_Strep PF09605.5 CDF90712.1 - 0.056 13.1 3.5 0.086 12.5 2.5 1.3 1 0 0 1 1 1 0 Hypothetical bacterial integral membrane protein (Trep_Strep) Aldo_ket_red PF00248.16 CDF90713.1 - 9.2e-54 182.1 0.0 1.1e-53 181.8 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family FHA PF00498.21 CDF90714.1 - 8.5e-05 22.5 0.1 0.00029 20.9 0.0 1.9 1 0 0 1 1 1 1 FHA domain BRCT PF00533.21 CDF90714.1 - 0.00064 19.8 0.0 0.0043 17.1 0.0 2.4 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Bac_surface_Ag PF01103.18 CDF90715.1 - 3.9e-22 79.1 0.9 4.5e-22 78.9 0.7 1.1 1 0 0 1 1 1 1 Surface antigen YCII PF03795.9 CDF90717.1 - 7.5e-05 22.8 0.1 8.9e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain Profilin PF00235.14 CDF90718.1 - 1.9e-39 134.4 0.0 2.1e-39 134.3 0.0 1.0 1 0 0 1 1 1 1 Profilin Leo1 PF04004.8 CDF90719.1 - 3e-43 147.4 0.0 3e-43 147.4 0.0 2.6 3 1 1 4 4 4 1 Leo1-like protein Glyco_hydro_18 PF00704.23 CDF90720.1 - 3.1e-76 257.0 1.8 4.6e-76 256.5 1.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 GPP34 PF05719.6 CDF90721.1 - 1.4e-62 211.4 0.0 1.8e-62 211.0 0.0 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) Asp PF00026.18 CDF90722.1 - 4.8e-75 252.7 8.0 6.8e-75 252.2 5.6 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 CDF90722.1 - 1.6e-08 34.6 0.0 2.6e-07 30.7 0.0 3.1 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 CDF90722.1 - 0.0011 19.4 0.7 1.3 9.5 0.0 3.5 3 0 0 3 3 3 1 Aspartyl protease TAXi_C PF14541.1 CDF90722.1 - 0.003 17.1 0.2 0.1 12.1 0.1 2.5 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp PF00026.18 CDF90723.1 - 5.6e-73 245.9 7.4 5.6e-73 245.9 5.1 1.9 2 1 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 CDF90723.1 - 1e-09 38.5 2.2 1e-09 38.5 1.5 2.8 3 0 0 3 3 3 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 CDF90723.1 - 2.5e-06 27.1 0.2 0.00014 21.4 0.1 2.5 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Dicty_REP PF05086.7 CDF90723.1 - 6.9 4.2 10.0 9.6 3.8 6.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Lin-8 PF03353.10 CDF90723.1 - 7.7 5.6 9.5 13 4.9 6.6 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Asp PF00026.18 CDF90724.1 - 2.4e-70 237.2 11.7 4.6e-60 203.5 2.0 2.1 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.1 CDF90724.1 - 1.9e-09 37.7 5.1 1.9e-07 31.1 2.8 3.4 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.1 CDF90724.1 - 1.4e-05 25.5 1.9 1.2 9.7 0.0 3.8 4 0 0 4 4 4 3 Aspartyl protease RVP PF00077.15 CDF90724.1 - 0.056 13.3 0.2 2.1 8.3 0.0 2.6 2 0 0 2 2 2 0 Retroviral aspartyl protease gag-asp_proteas PF13975.1 CDF90724.1 - 0.078 12.8 0.0 8.6 6.2 0.0 2.6 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Cullin PF00888.17 CDF90726.1 - 1e-30 106.8 0.0 1.9e-30 105.9 0.0 1.4 1 0 0 1 1 1 1 Cullin family APC2 PF08672.6 CDF90726.1 - 1.4e-19 70.1 0.0 1.6e-18 66.7 0.0 2.6 2 0 0 2 2 2 1 Anaphase promoting complex (APC) subunit 2 RPA_C PF08784.6 CDF90726.1 - 0.0026 18.1 0.0 0.0077 16.6 0.0 1.8 1 0 0 1 1 1 1 Replication protein A C terminal FeoC PF09012.5 CDF90726.1 - 0.013 15.2 0.0 0.1 12.3 0.0 2.5 3 0 0 3 3 3 0 FeoC like transcriptional regulator EAP30 PF04157.11 CDF90726.1 - 0.017 14.2 0.0 0.056 12.5 0.0 1.9 1 0 0 1 1 1 0 EAP30/Vps36 family TFIID_20kDa PF03847.8 CDF90727.1 - 7e-32 109.5 0.4 7e-32 109.5 0.3 2.0 2 0 0 2 2 2 1 Transcription initiation factor TFIID subunit A Histone PF00125.19 CDF90727.1 - 0.02 14.9 0.0 0.084 13.0 0.0 2.1 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 zf-C2H2 PF00096.21 CDF90728.1 - 7.1e-10 38.6 16.5 0.001 19.3 0.7 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CDF90728.1 - 4.3e-05 23.5 13.4 0.021 15.0 1.2 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CDF90728.1 - 0.00058 20.0 0.1 0.00058 20.0 0.0 4.1 4 0 0 4 4 4 1 Zinc-finger double domain Bunya_G2 PF03563.8 CDF90728.1 - 0.061 12.2 1.3 0.1 11.4 0.9 1.3 1 0 0 1 1 1 0 Bunyavirus glycoprotein G2 Peroxin-3 PF04882.7 CDF90728.1 - 0.065 11.9 3.7 0.1 11.3 2.6 1.2 1 0 0 1 1 1 0 Peroxin-3 PsbK PF02533.10 CDF90728.1 - 0.1 12.5 0.1 0.19 11.6 0.1 1.4 1 0 0 1 1 1 0 Photosystem II 4 kDa reaction centre component zf-C2H2_jaz PF12171.3 CDF90728.1 - 0.17 12.0 10.7 6.8 6.9 0.4 3.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 CDF90728.1 - 5.1 7.1 10.3 1.1 9.3 0.1 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger HVSL PF09749.4 CDF90729.1 - 1.4e-26 93.0 0.0 1.7e-26 92.7 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein Choline_kinase PF01633.15 CDF90730.1 - 7e-66 221.8 0.0 1e-65 221.2 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kin_N PF04428.9 CDF90730.1 - 5.2e-09 35.4 0.0 1.1e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 Choline kinase N terminus APH PF01636.18 CDF90730.1 - 4.1e-07 29.9 0.0 0.006 16.3 0.0 2.6 2 1 0 2 2 2 2 Phosphotransferase enzyme family 2-oxoacid_dh PF00198.18 CDF90731.1 - 3.5e-79 265.3 0.1 5.1e-79 264.8 0.1 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 CDF90731.1 - 2.7e-16 58.9 0.5 5.9e-16 57.8 0.4 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme GCV_H PF01597.14 CDF90731.1 - 0.00023 20.8 0.1 0.00052 19.6 0.1 1.6 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl_2 PF13533.1 CDF90731.1 - 0.00031 20.3 0.3 0.0009 18.8 0.2 1.7 1 1 0 1 1 1 1 Biotin-lipoyl like HlyD_3 PF13437.1 CDF90731.1 - 0.00058 20.1 0.0 0.0016 18.7 0.0 1.8 1 0 0 1 1 1 1 HlyD family secretion protein HlyD_2 PF12700.2 CDF90731.1 - 0.00062 19.0 0.6 0.00082 18.6 0.4 1.3 1 0 0 1 1 1 1 HlyD family secretion protein BioT2 PF15368.1 CDF90731.1 - 0.0046 16.7 0.0 0.0046 16.7 0.0 2.0 2 0 0 2 2 2 1 Spermatogenesis family BioT2 DUF2118 PF09891.4 CDF90731.1 - 0.01 15.5 0.0 0.022 14.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) HlyD PF00529.15 CDF90731.1 - 0.018 14.3 0.1 0.03 13.6 0.0 1.5 1 0 0 1 1 1 0 HlyD family secretion protein RnfC_N PF13375.1 CDF90731.1 - 0.022 14.4 0.1 0.16 11.6 0.0 2.3 1 1 0 1 1 1 0 RnfC Barrel sandwich hybrid domain YL1 PF05764.8 CDF90731.1 - 0.5 9.9 14.8 0.87 9.1 10.2 1.3 1 0 0 1 1 1 0 YL1 nuclear protein RR_TM4-6 PF06459.7 CDF90731.1 - 3.3 7.5 11.7 4.7 7.0 8.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Slx4 PF09494.5 CDF90732.1 - 1.9e-15 56.3 0.0 3.8e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 Slx4 endonuclease DDE_Tnp_IS240 PF13610.1 CDF90732.1 - 0.1 12.5 1.9 4.3 7.3 0.0 2.4 2 0 0 2 2 2 0 DDE domain Mcp5_PH PF12814.2 CDF90733.1 - 1.2e-34 118.9 0.5 3.6e-34 117.3 0.0 2.2 2 0 0 2 2 2 1 Meiotic cell cortex C-terminal pleckstrin homology zf-CCCH PF00642.19 CDF90734.1 - 5.3e-18 64.2 17.5 6e-10 38.5 2.1 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.1 CDF90734.1 - 0.0025 17.7 11.5 0.008 16.1 0.4 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type zf-C2H2_4 PF13894.1 CDF90735.1 - 2.3 8.7 4.7 1.1 9.7 0.1 2.8 3 0 0 3 3 3 0 C2H2-type zinc finger ATP1G1_PLM_MAT8 PF02038.11 CDF90736.1 - 0.081 11.9 0.2 0.11 11.5 0.1 1.2 1 0 0 1 1 1 0 ATP1G1/PLM/MAT8 family Pmp3 PF01679.12 CDF90737.1 - 3.6e-15 55.3 6.0 4.6e-15 55.0 4.2 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Rhomboid PF01694.17 CDF90737.1 - 0.088 12.8 0.5 0.097 12.6 0.4 1.0 1 0 0 1 1 1 0 Rhomboid family BTP PF05232.7 CDF90737.1 - 0.12 12.1 0.9 0.16 11.7 0.7 1.1 1 0 0 1 1 1 0 Bacterial Transmembrane Pair family DEAD PF00270.24 CDF90738.1 - 1.3e-38 132.1 0.7 8.6e-36 122.9 0.2 2.1 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF90738.1 - 1.3e-26 92.2 0.1 2.4e-26 91.3 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDF90738.1 - 6.7e-05 22.7 0.0 0.00022 21.1 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.1 CDF90738.1 - 0.00016 21.6 0.0 0.002 18.1 0.0 2.1 2 0 0 2 2 2 1 Helicase C-terminal domain Helicase_RecD PF05127.9 CDF90738.1 - 0.011 15.3 0.1 0.031 13.9 0.0 1.8 1 1 1 2 2 2 0 Helicase CMS1 PF14617.1 CDF90738.1 - 0.017 14.2 0.1 0.054 12.5 0.1 1.8 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit AAA_30 PF13604.1 CDF90738.1 - 0.025 14.1 0.0 0.059 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Trypan_PARP PF05887.6 CDF90738.1 - 0.81 9.4 7.9 1.4 8.7 5.5 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) XRN_N PF03159.13 CDF90740.1 - 3.7e-108 360.3 2.0 2.5e-107 357.6 0.0 2.4 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus Hid1 PF12722.2 CDF90740.1 - 3.9 5.0 9.6 7.5 4.1 6.6 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Methyltransf_28 PF02636.12 CDF90741.1 - 8.6e-09 35.1 0.0 1.5e-08 34.3 0.0 1.4 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase RTA1 PF04479.8 CDF90742.1 - 3.5e-68 229.4 14.8 4.7e-68 229.0 10.3 1.2 1 0 0 1 1 1 1 RTA1 like protein Acyltransferase PF01553.16 CDF90743.1 - 1.1e-05 24.9 0.0 0.0001 21.7 0.0 2.2 1 1 0 1 1 1 1 Acyltransferase DUF3816 PF12822.2 CDF90743.1 - 0.046 13.6 3.5 0.75 9.6 2.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3816) TRAPP PF04051.11 CDF90744.1 - 7.5e-36 122.9 0.0 1.8e-35 121.7 0.0 1.5 2 0 0 2 2 2 1 Transport protein particle (TRAPP) component DUF111 PF01969.12 CDF90744.1 - 0.018 13.8 0.0 0.24 10.1 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function DUF111 Dsl1_N PF11988.3 CDF90744.1 - 0.082 11.7 0.1 0.16 10.8 0.0 1.5 2 0 0 2 2 2 0 Retrograde transport protein Dsl1 N terminal Nro1 PF12753.2 CDF90745.1 - 3.4e-147 490.6 20.6 3.8e-147 490.4 14.3 1.0 1 0 0 1 1 1 1 Nuclear pore complex subunit Nro1 Dak2 PF02734.12 CDF90745.1 - 0.43 10.2 3.4 7.2 6.2 0.0 2.7 2 1 0 2 2 2 0 DAK2 domain TP_methylase PF00590.15 CDF90746.1 - 3.8e-40 137.8 0.2 9.5e-40 136.5 0.0 1.6 2 0 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases NAD_binding_7 PF13241.1 CDF90746.1 - 3.8e-08 33.5 0.0 8.3e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_M PF14824.1 CDF90746.1 - 0.0027 16.6 0.1 0.0067 15.3 0.0 1.7 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Sirohm_synth_C PF14823.1 CDF90746.1 - 0.17 11.2 0.2 15 4.9 0.0 2.5 2 0 0 2 2 2 0 Sirohaem biosynthesis protein C-terminal zf-AN1 PF01428.11 CDF90748.1 - 3.8e-09 36.2 13.6 5.6e-09 35.7 9.4 1.3 1 0 0 1 1 1 1 AN1-like Zinc finger Transp_Tc5_C PF04236.10 CDF90748.1 - 0.11 12.7 6.9 0.18 12.0 4.8 1.3 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain DUF3020 PF11223.3 CDF90748.1 - 4.9 7.6 6.5 0.48 10.8 1.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3020) Flavoprotein PF02441.14 CDF90749.1 - 7.1e-44 148.6 0.3 1.9e-43 147.1 0.2 1.7 1 1 0 1 1 1 1 Flavoprotein NOB1_Zn_bind PF08772.6 CDF90750.1 - 4.6e-26 90.4 0.2 9e-26 89.5 0.1 1.5 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like Zn-ribbon_8 PF09723.5 CDF90750.1 - 0.063 13.2 0.5 0.19 11.7 0.4 1.8 1 0 0 1 1 1 0 Zinc ribbon domain zf-FCS PF06467.9 CDF90750.1 - 0.21 11.2 0.9 0.46 10.1 0.6 1.5 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif Nucleo_P87 PF07267.6 CDF90750.1 - 2.5 6.7 7.0 4.4 5.8 4.9 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 SGS PF05002.10 CDF90751.1 - 7.4e-28 96.1 1.5 7.4e-28 96.1 1.0 2.4 2 0 0 2 2 2 1 SGS domain CS PF04969.11 CDF90751.1 - 1.9e-15 57.1 0.8 3.7e-15 56.2 0.6 1.5 1 0 0 1 1 1 1 CS domain TPR_12 PF13424.1 CDF90751.1 - 0.041 13.8 0.6 0.14 12.1 0.4 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.1 CDF90751.1 - 0.046 13.3 5.8 1.3 8.6 1.0 2.5 2 0 0 2 2 2 0 TPR repeat TPR_2 PF07719.12 CDF90751.1 - 2.6 8.1 7.4 4.3 7.4 0.3 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat MAP65_ASE1 PF03999.7 CDF90752.1 - 2.1e-79 267.7 26.4 4.5e-79 266.6 18.3 1.6 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) DUF148 PF02520.12 CDF90752.1 - 0.012 15.4 2.2 0.012 15.4 1.5 3.0 2 0 0 2 2 2 0 Domain of unknown function DUF148 rve_2 PF13333.1 CDF90752.1 - 0.075 13.1 1.5 0.17 11.9 0.2 2.3 2 0 0 2 2 2 0 Integrase core domain DUF2340 PF10209.4 CDF90753.1 - 8.7e-56 187.3 0.7 1e-55 187.1 0.5 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) DUF676 PF05057.9 CDF90754.1 - 1.8e-49 167.9 0.2 2.7e-49 167.4 0.1 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.8 CDF90754.1 - 0.00011 21.9 0.0 0.00022 20.8 0.0 1.6 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_5 PF12695.2 CDF90754.1 - 0.0004 20.1 0.0 0.00074 19.2 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.20 CDF90754.1 - 0.0025 17.4 0.0 0.65 9.6 0.0 2.5 2 0 0 2 2 2 2 Lipase (class 3) Abhydrolase_6 PF12697.2 CDF90754.1 - 0.0029 17.5 0.1 0.057 13.2 0.1 2.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDF90754.1 - 0.13 11.8 0.1 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Pkinase PF00069.20 CDF90756.1 - 2.6e-53 180.8 0.0 3.2e-53 180.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF90756.1 - 2.2e-16 59.6 0.0 3.5e-16 59.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CDF90756.1 - 4.5e-07 29.8 0.0 1.7e-06 27.9 0.1 1.9 3 0 0 3 3 3 1 Phosphotransferase enzyme family Choline_kinase PF01633.15 CDF90756.1 - 0.011 15.3 0.1 0.02 14.4 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase TFIID-31kDa PF02291.10 CDF90756.1 - 0.07 12.9 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Ribosomal_L3 PF00297.17 CDF90759.1 - 2.9e-119 397.3 8.2 3.4e-119 397.0 5.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 FadA PF09403.5 CDF90759.1 - 0.086 12.8 0.5 0.19 11.7 0.4 1.5 1 0 0 1 1 1 0 Adhesion protein FadA AhpC-TSA PF00578.16 CDF90760.1 - 2.1e-32 111.4 0.0 3e-32 110.9 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.4 CDF90760.1 - 1.7e-14 53.1 0.1 3.3e-14 52.2 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.5 CDF90760.1 - 1.7e-10 40.5 0.0 2.6e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.1 CDF90760.1 - 0.0062 16.4 0.0 0.0092 15.8 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme Fungal_trans PF04082.13 CDF90761.1 - 4.3e-25 88.0 2.3 4.3e-25 88.0 1.6 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF90761.1 - 1.2e-09 37.9 9.7 2e-09 37.1 6.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UCH PF00443.24 CDF90762.1 - 2e-74 250.0 14.9 1.2e-72 244.3 10.3 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CDF90762.1 - 3.3e-20 72.6 0.4 8.6e-17 61.5 0.1 3.9 4 1 0 4 4 4 2 Ubiquitin carboxyl-terminal hydrolase Pribosyltran_N PF13793.1 CDF90763.1 - 5.6e-44 148.5 0.2 2.6e-41 139.9 0.0 2.4 2 1 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 CDF90763.1 - 4.9e-35 120.9 1.1 6.3e-29 101.0 0.4 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 CDF90763.1 - 4.2e-14 52.3 0.4 1.2e-12 47.5 0.2 2.4 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.1 CDF90763.1 - 0.0054 15.9 0.1 0.0083 15.3 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase UQ_con PF00179.21 CDF90764.1 - 1.3e-28 99.1 0.1 1.8e-28 98.6 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 CDF90764.1 - 0.018 14.9 0.3 0.034 14.0 0.1 1.6 2 0 0 2 2 2 0 RWD domain ADH_zinc_N_2 PF13602.1 CDF90765.1 - 5.4e-13 49.9 0.0 1e-12 49.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CDF90765.1 - 7.1e-07 28.9 0.1 1.3e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CDF90765.1 - 0.042 13.3 0.0 0.18 11.3 0.0 2.0 1 1 0 1 1 1 0 Zinc-binding dehydrogenase zf-CSL PF05207.8 CDF90766.1 - 1.2e-22 79.1 1.6 1.5e-22 78.8 1.1 1.2 1 0 0 1 1 1 1 CSL zinc finger TF_Zn_Ribbon PF08271.7 CDF90766.1 - 0.021 14.1 1.3 0.021 14.1 0.9 1.7 2 0 0 2 2 2 0 TFIIB zinc-binding ATPase-cat_bd PF12156.3 CDF90766.1 - 0.058 13.9 0.0 0.081 13.4 0.0 1.2 1 0 0 1 1 1 0 Putative metal-binding domain of cation transport ATPase Ribosomal_S8e PF01201.17 CDF90767.1 - 1.5e-50 170.7 1.7 1.7e-50 170.5 1.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e AAR2 PF05282.6 CDF90768.1 - 8e-53 179.6 0.1 9.3e-53 179.4 0.1 1.0 1 0 0 1 1 1 1 AAR2 protein HSP70 PF00012.15 CDF90769.1 - 4.9e-267 886.7 6.9 5.6e-267 886.5 4.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 CDF90769.1 - 9.2e-17 60.6 0.3 8.9e-16 57.3 0.1 2.0 2 0 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.13 CDF90769.1 - 0.019 14.0 0.2 0.019 14.0 0.1 2.1 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase FGGY_C PF02782.11 CDF90769.1 - 0.039 13.5 0.0 0.076 12.6 0.0 1.5 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain DUF3813 PF12758.2 CDF90769.1 - 0.099 12.7 2.5 6.8 6.9 0.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3813) tRNA-synt_1 PF00133.17 CDF90770.1 - 1.1e-234 779.9 0.1 3.5e-234 778.2 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 CDF90770.1 - 1e-27 96.7 0.0 3.8e-27 94.9 0.0 2.0 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 CDF90770.1 - 4.7e-20 71.6 1.8 8e-07 28.0 0.4 4.2 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 CDF90770.1 - 0.00038 19.6 0.0 0.0013 17.9 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain ArsC PF03960.10 CDF90771.1 - 0.094 12.7 1.9 0.22 11.6 1.3 1.6 1 0 0 1 1 1 0 ArsC family Atg8 PF02991.11 CDF90772.1 - 1.3e-50 169.6 0.1 1.5e-50 169.4 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.8 CDF90772.1 - 8.9e-07 29.0 0.0 1.2e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Nucleoporin_C PF03177.9 CDF90773.1 - 6.2e-132 441.0 10.2 8.2e-132 440.6 7.1 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.6 CDF90773.1 - 5.4e-114 381.2 10.7 5.5e-114 381.1 6.6 1.7 2 0 0 2 2 2 1 Nup133 N terminal like MAM1 PF10434.4 CDF90774.1 - 6.1e-28 97.7 9.9 2.3e-27 95.8 6.9 1.8 1 1 0 1 1 1 1 Monopolin complex protein MAM1 GatB_N PF02934.10 CDF90775.1 - 8.8e-94 313.5 0.0 1.2e-93 313.1 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.13 CDF90775.1 - 8.9e-31 106.6 0.1 1.7e-30 105.7 0.1 1.4 1 0 0 1 1 1 1 GatB domain WD40 PF00400.27 CDF90777.1 - 1e-26 91.7 6.6 1.5e-06 27.8 0.0 4.4 4 0 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.3 CDF90777.1 - 2.2e-05 22.8 0.3 0.01 14.0 0.0 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 eIF2A PF08662.6 CDF90777.1 - 8.2e-05 22.3 0.0 1.9 8.1 0.0 3.3 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A LisH PF08513.6 CDF90778.1 - 1.9e-06 27.4 0.3 3.9e-06 26.4 0.2 1.6 1 0 0 1 1 1 1 LisH HSP70 PF00012.15 CDF90778.1 - 0.057 11.3 0.0 0.073 10.9 0.0 1.1 1 0 0 1 1 1 0 Hsp70 protein ALG3 PF05208.8 CDF90779.1 - 4.6e-115 384.7 20.9 6.6e-115 384.2 14.5 1.1 1 0 0 1 1 1 1 ALG3 protein HEAT_EZ PF13513.1 CDF90780.1 - 8.9e-15 54.6 0.7 0.068 13.6 0.0 8.5 8 1 1 9 9 9 3 HEAT-like repeat IBN_N PF03810.14 CDF90780.1 - 1.2e-12 47.5 5.3 4.1e-09 36.2 0.4 4.6 4 0 0 4 4 4 2 Importin-beta N-terminal domain HEAT PF02985.17 CDF90780.1 - 4.2e-12 45.0 1.1 0.19 11.9 0.0 8.4 7 0 0 7 7 7 3 HEAT repeat HEAT_2 PF13646.1 CDF90780.1 - 1.3e-10 41.3 7.6 0.013 15.7 0.2 6.6 4 1 2 6 6 6 5 HEAT repeats Sec7_N PF12783.2 CDF90780.1 - 0.013 14.9 0.3 0.28 10.5 0.0 2.8 1 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Ipi1_N PF12333.3 CDF90780.1 - 0.028 14.3 3.2 4.4 7.3 0.0 5.0 7 0 0 7 7 7 0 Rix1 complex component involved in 60S ribosome maturation Ank PF00023.25 CDF90781.1 - 7e-10 38.2 6.6 0.00022 20.8 0.5 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.2 CDF90781.1 - 2.6e-09 37.3 2.1 0.0014 18.9 0.1 2.9 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CDF90781.1 - 8.1e-09 35.7 5.0 5.8e-05 23.4 0.9 3.4 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDF90781.1 - 1e-07 31.4 2.7 0.028 14.6 0.2 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.1 CDF90781.1 - 1.8e-07 31.1 5.4 0.0089 16.2 0.2 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) KilA-N PF04383.8 CDF90781.1 - 7.9e-06 25.4 0.4 3.5e-05 23.3 0.3 2.1 1 1 0 1 1 1 1 KilA-N domain LSM PF01423.17 CDF90782.1 - 8.7e-16 57.2 1.1 1.2e-15 56.7 0.3 1.5 2 0 0 2 2 2 1 LSM domain SM-ATX PF14438.1 CDF90782.1 - 0.0004 20.2 0.0 0.00068 19.5 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF2763 PF10961.3 CDF90782.1 - 0.41 11.0 4.3 0.86 10.0 3.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2763) EMP70 PF02990.11 CDF90783.1 - 6e-120 401.1 13.4 7.5e-120 400.8 9.3 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 Baculo_VP91_N PF08475.5 CDF90783.1 - 0.21 10.9 1.2 9.8 5.4 0.0 2.5 2 0 0 2 2 2 0 Viral capsid protein 91 N-terminal TPR_2 PF07719.12 CDF90784.1 - 5.7e-40 132.0 10.4 3e-08 32.9 0.4 8.7 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_1 PF00515.23 CDF90784.1 - 8.9e-37 123.2 14.0 6.5e-10 38.1 0.6 8.6 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_11 PF13414.1 CDF90784.1 - 4.2e-35 119.2 15.8 5.3e-13 48.4 0.7 6.6 5 2 2 7 7 7 5 TPR repeat TPR_8 PF13181.1 CDF90784.1 - 2.7e-27 92.4 8.2 4.2e-07 29.2 0.2 8.6 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.1 CDF90784.1 - 5.7e-23 81.0 1.8 2.6e-08 34.3 0.0 5.5 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_12 PF13424.1 CDF90784.1 - 3.4e-22 78.1 10.7 1.1e-06 28.5 0.1 7.1 6 1 1 7 7 7 5 Tetratricopeptide repeat Apc3 PF12895.2 CDF90784.1 - 1.1e-21 76.7 26.9 3.3e-14 52.7 0.5 4.9 5 0 0 5 5 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.1 CDF90784.1 - 9.7e-19 65.9 14.7 1.8e-05 24.5 0.2 9.4 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_7 PF13176.1 CDF90784.1 - 2.2e-14 51.9 7.9 0.00032 20.2 0.0 7.6 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_19 PF14559.1 CDF90784.1 - 4.8e-14 52.4 4.2 1.5e-05 25.2 0.0 5.4 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_14 PF13428.1 CDF90784.1 - 3.4e-13 48.9 0.2 0.037 14.6 0.0 6.7 4 2 3 7 7 6 3 Tetratricopeptide repeat TPR_6 PF13174.1 CDF90784.1 - 4e-09 36.3 13.7 0.007 16.7 0.1 8.3 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_9 PF13371.1 CDF90784.1 - 1.5e-08 34.3 0.9 0.0027 17.5 0.1 4.6 3 2 2 5 5 4 3 Tetratricopeptide repeat TPR_15 PF13429.1 CDF90784.1 - 3.6e-07 29.5 0.1 0.0056 15.7 0.0 3.9 2 1 1 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.1 CDF90784.1 - 2.5e-05 24.0 5.6 0.032 14.1 0.0 4.4 5 0 0 5 5 3 2 Tetratricopeptide repeat BAF1_ABF1 PF04684.8 CDF90784.1 - 2.6e-05 23.2 7.9 4e-05 22.6 5.5 1.2 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor ChAPs PF09295.5 CDF90784.1 - 0.00035 19.4 0.1 0.026 13.2 0.0 2.7 2 0 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) Sel1 PF08238.7 CDF90784.1 - 0.0023 18.5 7.8 6.3 7.5 0.0 4.5 4 0 0 4 4 3 0 Sel1 repeat AAA_11 PF13086.1 CDF90784.1 - 0.003 17.1 2.8 0.003 17.1 1.9 1.8 2 0 0 2 2 2 1 AAA domain TPR_20 PF14561.1 CDF90784.1 - 0.0047 17.0 0.1 6.7 6.9 0.1 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat PPR PF01535.15 CDF90784.1 - 0.0063 16.4 0.8 5.4 7.2 0.3 3.3 2 0 0 2 2 2 1 PPR repeat PAT1 PF09770.4 CDF90784.1 - 0.08 11.1 24.1 0.11 10.7 16.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Fis1_TPR_C PF14853.1 CDF90784.1 - 0.17 11.8 9.0 1.3 8.9 0.1 5.5 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat SR-25 PF10500.4 CDF90784.1 - 0.56 9.6 16.8 0.27 10.6 10.2 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4175 PF13779.1 CDF90784.1 - 3.5 5.1 16.3 5.1 4.6 11.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) PH PF00169.24 CDF90785.1 - 5.5e-13 49.0 0.0 1.6e-12 47.5 0.0 1.8 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.23 CDF90785.1 - 4.2e-12 45.2 0.2 8.4e-12 44.2 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SAM_2 PF07647.12 CDF90785.1 - 3.8e-11 42.6 0.0 7.1e-11 41.8 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_9 PF14604.1 CDF90785.1 - 2.2e-08 33.5 0.1 4.9e-08 32.4 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.1 CDF90785.1 - 1.1e-07 32.0 0.1 7.8e-07 29.3 0.0 2.6 2 1 0 2 2 2 1 Pleckstrin homology domain SAM_1 PF00536.25 CDF90785.1 - 0.00017 21.6 0.0 0.00036 20.6 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_8 PF15409.1 CDF90785.1 - 0.00061 19.8 0.0 0.012 15.6 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain SH3_2 PF07653.12 CDF90785.1 - 0.0041 16.5 0.0 0.0087 15.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain NT-C2 PF10358.4 CDF90786.1 - 1.4e-45 154.2 0.2 9.3e-45 151.6 0.1 2.1 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins zf-C3HC4 PF00097.20 CDF90788.1 - 3.6e-10 39.3 7.5 5.5e-10 38.7 5.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CDF90788.1 - 4.5e-10 39.0 6.7 6.4e-10 38.5 4.6 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CDF90788.1 - 1.2e-09 37.7 8.0 1.9e-09 37.1 5.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.1 CDF90788.1 - 4.1e-08 32.8 7.2 6.1e-08 32.2 5.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.1 CDF90788.1 - 8.8e-08 32.0 8.5 1.4e-07 31.3 5.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.1 CDF90788.1 - 3.3e-06 26.7 6.0 6.2e-06 25.8 4.1 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 CDF90788.1 - 5e-05 23.1 8.2 7.9e-05 22.4 5.7 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Apc11 PF12861.2 CDF90788.1 - 0.00021 21.0 1.0 0.00029 20.6 0.7 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.1 CDF90788.1 - 0.01 15.3 4.5 0.027 14.0 3.1 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.2 CDF90788.1 - 0.045 13.8 4.3 0.11 12.6 3.0 1.6 1 1 0 1 1 1 0 RING-H2 zinc finger Dsh_C PF12316.3 CDF90788.1 - 0.23 11.5 1.7 0.28 11.2 1.2 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal zf-MIZ PF02891.15 CDF90788.1 - 0.3 10.6 6.6 0.77 9.3 4.6 1.7 1 1 1 2 2 2 0 MIZ/SP-RING zinc finger zf-RING_6 PF14835.1 CDF90788.1 - 2.2 8.1 6.1 18 5.1 4.2 2.3 1 1 0 1 1 1 0 zf-RING of BARD1-type protein DUF1644 PF07800.7 CDF90788.1 - 7.4 6.4 8.8 6.5 6.5 2.4 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1644) Ribosomal_L14 PF00238.14 CDF90789.1 - 3.4e-31 107.5 0.0 3.9e-31 107.3 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e PI3_PI4_kinase PF00454.22 CDF90790.1 - 1.1e-48 165.8 0.0 3.1e-48 164.2 0.0 1.8 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.3 CDF90790.1 - 2e-29 102.3 3.3 6e-29 100.7 2.3 1.9 1 0 0 1 1 1 1 Telomere-length maintenance and DNA damage repair FATC PF02260.15 CDF90790.1 - 7.3e-14 50.9 0.1 2.3e-13 49.3 0.1 1.9 1 0 0 1 1 1 1 FATC domain SH3_9 PF14604.1 CDF90791.1 - 1.2e-10 40.7 0.1 2.3e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 CDF90791.1 - 1.9e-10 39.9 0.1 3.1e-10 39.2 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 CDF90791.1 - 1.1e-08 34.3 0.0 2.1e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain zf-DHHC PF01529.15 CDF90791.1 - 0.53 9.6 3.7 1 8.7 2.5 1.5 1 0 0 1 1 1 0 DHHC palmitoyltransferase Aa_trans PF01490.13 CDF90792.1 - 1.1e-100 337.0 17.5 1.3e-100 336.8 12.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.8 CDF90792.1 - 3e-06 26.3 10.1 3e-06 26.3 7.0 1.7 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family Abhydrolase_9_N PF15420.1 CDF90792.1 - 0.45 10.2 9.7 0.88 9.2 0.1 3.8 4 1 1 5 5 5 0 Alpha/beta-hydrolase family N-terminus Ribosomal_S21 PF01165.15 CDF90793.1 - 5.5e-12 44.9 0.3 1.2e-11 43.8 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S21 Peptidase_M24 PF00557.19 CDF90794.1 - 1.1e-47 162.3 0.0 1.5e-47 161.8 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Motile_Sperm PF00635.21 CDF90795.1 - 3.5e-25 87.7 0.0 5.5e-25 87.1 0.0 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain SCF PF02404.10 CDF90795.1 - 0.088 11.9 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Stem cell factor Ribosomal_L32e PF01655.13 CDF90796.1 - 3.5e-43 146.1 0.8 4.1e-43 145.9 0.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L32 Asn_synthase PF00733.16 CDF90797.1 - 8.8e-67 225.2 0.0 1.2e-66 224.8 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 CDF90797.1 - 3.5e-34 117.2 0.0 5.6e-34 116.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 CDF90797.1 - 9.8e-29 99.9 0.0 2e-28 98.9 0.0 1.5 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.3 CDF90797.1 - 2.5e-07 30.1 0.0 4.4e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein GATase_2 PF00310.16 CDF90797.1 - 7.7e-05 21.5 0.0 0.46 9.1 0.0 3.0 1 1 2 3 3 3 2 Glutamine amidotransferases class-II NAD_synthase PF02540.12 CDF90797.1 - 0.035 13.0 0.0 0.057 12.3 0.0 1.3 1 0 0 1 1 1 0 NAD synthase DUF3764 PF12594.3 CDF90797.1 - 0.044 13.5 0.0 0.099 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3764) CBF PF03914.12 CDF90799.1 - 5.2e-45 152.8 1.3 9.9e-45 151.9 0.2 2.0 2 0 0 2 2 2 1 CBF/Mak21 family Lipase_GDSL_3 PF14606.1 CDF90799.1 - 0.1 12.2 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Metallophos PF00149.23 CDF90800.1 - 1.9e-36 125.3 0.1 3e-36 124.7 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_11 PF13414.1 CDF90800.1 - 2.2e-25 88.1 3.7 1.2e-18 66.5 0.8 2.8 1 1 1 2 2 2 2 TPR repeat TPR_1 PF00515.23 CDF90800.1 - 2.8e-18 64.6 5.3 1.6e-06 27.4 0.0 4.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.12 CDF90800.1 - 1.1e-15 56.1 2.5 3.5e-05 23.3 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat PPP5 PF08321.7 CDF90800.1 - 2.1e-11 43.6 0.8 0.00017 21.5 0.0 3.1 2 1 1 3 3 3 2 PPP5 TPR repeat region TPR_9 PF13371.1 CDF90800.1 - 3.4e-09 36.4 0.1 9.1e-07 28.6 0.0 2.2 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.1 CDF90800.1 - 1e-08 34.3 3.8 0.057 13.2 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.1 CDF90800.1 - 2.2e-08 33.6 3.4 0.0004 20.3 0.0 3.5 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_16 PF13432.1 CDF90800.1 - 5.1e-08 33.3 0.3 3.5e-05 24.3 0.0 2.5 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 CDF90800.1 - 1.1e-05 25.6 1.4 0.003 17.8 0.2 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.1 CDF90800.1 - 1.7e-05 25.0 0.6 0.49 11.1 0.0 3.5 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.1 CDF90800.1 - 0.0002 21.2 3.8 0.021 14.7 0.1 2.7 2 1 1 3 3 2 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 CDF90800.1 - 0.00038 20.2 0.2 0.056 13.3 0.0 2.7 1 1 1 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.1 CDF90800.1 - 0.003 17.2 0.1 1.2 9.1 0.0 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat NBP1 PF08537.5 CDF90800.1 - 0.071 12.3 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 TPR_6 PF13174.1 CDF90800.1 - 0.59 10.7 2.9 50 4.6 0.1 3.8 4 0 0 4 4 3 0 Tetratricopeptide repeat Kinesin PF00225.18 CDF90801.1 - 5.3e-103 344.2 4.3 5.3e-103 344.2 3.0 2.2 2 0 0 2 2 2 1 Kinesin motor domain Glyco_trans_4_2 PF13477.1 CDF90801.1 - 0.1 12.4 1.9 0.35 10.7 0.0 2.7 3 0 0 3 3 3 0 Glycosyl transferase 4-like Acyltransferase PF01553.16 CDF90802.1 - 8.1e-13 47.9 0.0 1.6e-12 46.9 0.0 1.4 1 1 0 1 1 1 1 Acyltransferase Ammonium_transp PF00909.16 CDF90804.1 - 4e-118 394.3 25.8 4.7e-118 394.1 17.9 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family ABC2_membrane_2 PF12679.2 CDF90804.1 - 0.0078 15.0 4.2 0.026 13.3 2.9 1.8 1 0 0 1 1 1 1 ABC-2 family transporter protein COX6A PF02046.10 CDF90804.1 - 0.034 14.0 0.1 0.076 12.9 0.0 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIa WD40 PF00400.27 CDF90805.1 - 3e-24 83.9 0.5 5.9e-07 29.1 0.0 5.8 6 0 0 6 6 6 5 WD domain, G-beta repeat DUF3639 PF12341.3 CDF90806.1 - 9.8e-09 35.0 0.5 2.1e-08 34.0 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3639) DNA_pol_alpha_N PF12254.3 CDF90806.1 - 1.2e-05 25.0 1.4 3.2e-05 23.6 1.0 1.7 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal COG2 PF06148.6 CDF90807.1 - 4.3e-09 36.3 7.3 8e-09 35.4 2.6 2.1 1 1 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 LOH1CR12 PF10158.4 CDF90807.1 - 0.0091 15.7 0.8 0.24 11.1 0.1 2.4 1 1 1 2 2 2 1 Tumour suppressor protein Syntaxin_2 PF14523.1 CDF90807.1 - 0.17 11.9 4.7 0.46 10.5 1.5 2.4 1 1 1 2 2 2 0 Syntaxin-like protein Snapin_Pallidin PF14712.1 CDF90807.1 - 0.21 11.9 3.9 0.5 10.7 0.5 2.4 2 0 0 2 2 2 0 Snapin/Pallidin Nup54 PF13874.1 CDF90808.1 - 1.4e-42 144.6 3.8 1.4e-42 144.6 2.6 2.3 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.1 CDF90808.1 - 9.2e-07 29.0 48.5 1.7e-06 28.2 33.6 1.5 1 0 0 1 1 1 1 Nucleoporin FG repeat region Phage_Gp23 PF10669.4 CDF90808.1 - 0.17 12.0 0.2 0.17 12.0 0.1 2.4 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) Tom5 PF10642.4 CDF90810.1 - 8.8e-22 76.4 0.1 9.4e-22 76.4 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit or translocase Med26 PF08711.6 CDF90811.1 - 5.8e-13 48.1 0.0 1.2e-12 47.1 0.0 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Lsr2 PF11774.3 CDF90811.1 - 0.031 14.1 1.4 0.031 14.1 0.9 2.4 2 0 0 2 2 2 0 Lsr2 Phasin PF05597.6 CDF90811.1 - 6 6.6 9.7 2 8.1 2.8 2.6 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Ribosom_S12_S23 PF00164.20 CDF90812.1 - 2.4e-40 136.7 0.8 2.8e-40 136.5 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 WD40 PF00400.27 CDF90813.1 - 5e-08 32.5 0.2 0.43 10.5 0.0 5.3 5 0 0 5 5 5 2 WD domain, G-beta repeat LisH PF08513.6 CDF90813.1 - 0.052 13.3 0.1 0.094 12.5 0.0 1.4 1 0 0 1 1 1 0 LisH DUF4165 PF13752.1 CDF90813.1 - 0.15 11.8 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4165) Acetyltransf_1 PF00583.19 CDF90814.1 - 1.5e-11 44.1 0.0 2.5e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 CDF90814.1 - 2.9e-06 26.9 0.0 4.8e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.1 CDF90814.1 - 0.0009 19.3 0.0 0.0014 18.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CDF90814.1 - 0.0023 18.0 0.0 0.0033 17.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain LSM14 PF12701.2 CDF90815.1 - 1.2e-22 79.5 0.0 1.2e-22 79.5 0.0 2.1 2 0 0 2 2 2 1 Scd6-like Sm domain FDF PF09532.5 CDF90815.1 - 3.7e-07 30.6 5.7 1.1e-05 25.8 0.2 4.2 4 1 0 4 4 4 2 FDF domain SM-ATX PF14438.1 CDF90815.1 - 0.031 14.1 0.0 0.077 12.9 0.0 1.7 1 0 0 1 1 1 0 Ataxin 2 SM domain Mito_carr PF00153.22 CDF90816.1 - 2.2e-50 168.3 0.3 9e-19 66.9 0.0 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein Aldo_ket_red PF00248.16 CDF90817.1 - 2.6e-42 144.6 0.0 2.9e-42 144.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HIT PF01230.18 CDF90817.1 - 0.11 12.9 0.0 0.34 11.4 0.0 1.8 1 0 0 1 1 1 0 HIT domain LETM1 PF07766.8 CDF90818.1 - 5.8e-90 300.9 1.0 8.3e-90 300.4 0.7 1.2 1 0 0 1 1 1 1 LETM1-like protein SH2_2 PF14633.1 CDF90819.1 - 1.8e-105 350.8 3.6 1.8e-105 350.8 2.5 2.0 2 0 0 2 2 2 1 SH2 domain YqgF PF14639.1 CDF90819.1 - 1.1e-66 223.0 0.0 3.3e-66 221.4 0.0 1.9 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 DLD PF14878.1 CDF90819.1 - 1.9e-49 166.5 4.8 1.9e-49 166.5 3.3 3.3 3 0 0 3 3 3 1 Death-like domain of SPT6 HHH_7 PF14635.1 CDF90819.1 - 6.7e-45 151.4 0.7 3.5e-44 149.1 0.0 2.6 2 0 0 2 2 2 1 Helix-hairpin-helix motif HTH_44 PF14641.1 CDF90819.1 - 1.1e-35 122.2 1.6 1.1e-35 122.2 1.1 2.7 2 0 0 2 2 2 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.1 CDF90819.1 - 1.4e-20 73.2 19.3 1.4e-20 73.2 13.4 4.7 2 1 2 4 4 4 1 Acidic N-terminal SPT6 SH2 PF00017.19 CDF90819.1 - 9.9e-13 47.6 0.3 3e-12 46.1 0.1 2.0 2 0 0 2 2 2 1 SH2 domain Ctr PF04145.10 CDF90820.1 - 6e-26 91.2 4.4 6e-26 91.2 3.0 2.1 2 0 0 2 2 2 1 Ctr copper transporter family DASH_Dam1 PF08653.5 CDF90821.1 - 5.8e-29 99.6 0.6 1.1e-28 98.6 0.4 1.5 1 0 0 1 1 1 1 DASH complex subunit Dam1 SURF1 PF02104.10 CDF90822.1 - 2.2e-64 217.1 0.4 3e-64 216.7 0.3 1.2 1 0 0 1 1 1 1 SURF1 family Peptidase_M16 PF00675.15 CDF90823.1 - 3.6e-30 104.6 0.0 1.1e-29 103.0 0.0 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 CDF90823.1 - 4.1e-14 52.6 0.2 3.1e-05 23.7 0.0 4.0 4 1 0 4 4 4 3 Peptidase M16 inactive domain Peptidase_M4_C PF02868.10 CDF90823.1 - 0.1 12.3 2.1 0.64 9.7 0.0 2.6 3 0 0 3 3 3 0 Thermolysin metallopeptidase, alpha-helical domain Abhydrolase_6 PF12697.2 CDF90825.1 - 1.2e-21 77.6 0.0 1.7e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDF90825.1 - 7.7e-17 61.6 0.0 1.7e-16 60.4 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CDF90825.1 - 3.4e-07 30.1 0.0 8.1e-07 28.8 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.8 CDF90825.1 - 0.042 13.4 0.0 0.067 12.7 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase Hydrolase_4 PF12146.3 CDF90825.1 - 0.056 13.2 0.0 0.43 10.4 0.0 2.4 2 0 0 2 2 2 0 Putative lysophospholipase Abhydrolase_2 PF02230.11 CDF90825.1 - 0.083 12.3 0.1 0.3 10.5 0.0 1.9 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase GIT1_C PF12205.3 CDF90826.1 - 0.0092 15.8 0.1 0.073 12.9 0.0 2.0 2 0 0 2 2 2 1 G protein-coupled receptor kinase-interacting protein 1 C term Cyclin_N PF00134.18 CDF90828.1 - 5.7e-44 148.7 0.8 2.7e-41 140.1 0.2 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.14 CDF90828.1 - 1.1e-21 76.9 0.1 3.4e-21 75.3 0.0 1.8 1 0 0 1 1 1 1 Cyclin, C-terminal domain MCM PF00493.18 CDF90830.1 - 2e-135 450.8 0.3 3e-135 450.3 0.2 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 CDF90830.1 - 1.5e-18 67.3 4.1 1.7e-18 67.2 0.0 2.7 2 1 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 CDF90830.1 - 4.1e-07 29.3 0.0 1.1e-06 27.9 0.0 1.7 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 CDF90830.1 - 0.0053 16.2 0.0 0.013 15.0 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.6 CDF90830.1 - 0.018 14.6 0.0 0.048 13.2 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RRN3 PF05327.6 CDF90830.1 - 0.023 12.8 3.9 0.037 12.1 2.7 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 AAA_5 PF07728.9 CDF90830.1 - 0.029 14.1 0.0 0.06 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Phosphorylase PF00343.15 CDF90831.1 - 0 1013.4 2.0 0 1013.2 1.4 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase DUF3417 PF11897.3 CDF90831.1 - 0.076 12.9 3.1 0.93 9.4 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3417) Aminotran_1_2 PF00155.16 CDF90832.1 - 8.4e-26 90.7 0.0 1e-25 90.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 CDF90832.1 - 0.0022 17.0 0.1 0.013 14.5 0.0 2.1 3 0 0 3 3 3 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.16 CDF90832.1 - 0.0051 15.9 0.0 0.0084 15.2 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Peptidase_S10 PF00450.17 CDF90833.1 - 2.8e-98 329.8 0.0 3.9e-98 329.3 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Apt1 PF10351.4 CDF90833.1 - 0.00079 18.4 1.8 0.0016 17.4 1.2 1.4 1 0 0 1 1 1 1 Golgi-body localisation protein domain CDC45 PF02724.9 CDF90833.1 - 0.017 13.1 6.3 0.023 12.7 4.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1510 PF07423.6 CDF90833.1 - 0.16 11.3 0.0 0.16 11.3 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1510) CDP-OH_P_transf PF01066.16 CDF90834.1 - 1.9e-11 44.1 4.2 3.4e-11 43.3 2.9 1.4 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase Ribosomal_L28 PF00830.14 CDF90835.1 - 3e-20 71.7 0.5 6.6e-20 70.6 0.3 1.6 1 0 0 1 1 1 1 Ribosomal L28 family Fer2_4 PF13510.1 CDF90835.1 - 0.0065 16.2 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Ribosomal_L36e PF01158.13 CDF90836.1 - 3.4e-36 123.1 1.6 3.8e-36 122.9 1.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e ORC4_C PF14629.1 CDF90837.1 - 0.035 13.4 0.0 0.045 13.1 0.0 1.3 1 1 0 1 1 1 0 Origin recognition complex (ORC) subunit 4 C-terminus DUF3523 PF12037.3 CDF90837.1 - 0.051 12.5 2.2 0.058 12.3 1.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) DUF1903 PF08991.5 CDF90838.1 - 2e-25 88.7 7.7 2.2e-25 88.6 5.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1903) Cmc1 PF08583.5 CDF90838.1 - 0.043 13.5 6.2 0.089 12.5 0.5 2.2 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.8 CDF90838.1 - 0.11 12.3 3.8 0.1 12.5 2.0 1.4 1 1 0 1 1 1 0 CHCH domain CBM_10 PF02013.11 CDF90838.1 - 5.3 7.3 7.4 0.98 9.7 0.4 2.4 1 1 1 2 2 2 0 Cellulose or protein binding domain Glyco_hydro_63 PF03200.11 CDF90840.1 - 1.3e-05 23.2 8.3 0.00045 18.2 0.1 4.2 4 1 0 4 4 4 2 Mannosyl oligosaccharide glucosidase V-SNARE PF05008.10 CDF90841.1 - 3.5e-20 71.9 7.4 4e-20 71.7 3.5 2.1 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.3 CDF90841.1 - 6e-20 71.0 1.7 6e-20 71.0 1.1 2.7 2 1 1 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.8 CDF90841.1 - 0.0043 16.7 0.3 0.0043 16.7 0.2 2.2 2 0 0 2 2 2 1 Sec20 Nsp1_C PF05064.8 CDF90841.1 - 0.028 14.0 2.8 0.028 14.0 1.9 2.3 2 1 1 3 3 3 0 Nsp1-like C-terminal region PTPA PF03095.10 CDF90841.1 - 0.05 12.7 0.5 0.073 12.2 0.4 1.2 1 0 0 1 1 1 0 Phosphotyrosyl phosphate activator (PTPA) protein DUF106 PF01956.11 CDF90841.1 - 0.052 13.0 0.0 0.24 10.9 0.0 1.9 1 1 0 1 1 1 0 Integral membrane protein DUF106 Baculo_p24 PF05073.7 CDF90841.1 - 0.054 13.0 4.1 0.42 10.1 0.3 2.2 1 1 0 2 2 2 0 Baculovirus P24 capsid protein DUF3811 PF11656.3 CDF90841.1 - 0.12 12.4 1.2 5.4 7.1 0.0 2.7 2 1 1 3 3 3 0 YjbD family (DUF3811) DUF2378 PF09536.5 CDF90841.1 - 0.17 11.3 1.1 1 8.8 0.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2378) YqjK PF13997.1 CDF90841.1 - 0.18 12.0 2.0 0.45 10.7 0.0 2.6 2 0 0 2 2 2 0 YqjK-like protein Snapin_Pallidin PF14712.1 CDF90841.1 - 0.34 11.2 6.8 1.2 9.4 2.7 2.7 2 1 0 2 2 2 0 Snapin/Pallidin DUF883 PF05957.8 CDF90841.1 - 0.92 9.9 3.6 12 6.3 0.6 2.9 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Fusion_gly PF00523.13 CDF90841.1 - 0.99 7.3 5.1 1.2 7.1 0.3 2.4 2 1 1 3 3 3 0 Fusion glycoprotein F0 Prominin PF05478.6 CDF90841.1 - 1.3 6.4 6.8 6 4.2 4.7 1.9 1 1 0 1 1 1 0 Prominin DUF4071 PF13281.1 CDF90841.1 - 2.1 7.0 7.2 0.83 8.4 0.3 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4071) Use1 PF09753.4 CDF90841.1 - 2.8 7.3 7.8 31 3.9 5.4 2.3 1 1 0 1 1 1 0 Membrane fusion protein Use1 Fer2 PF00111.22 CDF90842.1 - 3.1e-15 55.6 0.3 4.4e-15 55.1 0.2 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Lentivirus_VIF PF05851.6 CDF90843.1 - 0.46 9.1 4.6 3 6.4 0.1 3.0 2 1 0 3 3 3 0 Lentivirus virion infectivity factor (VIF) SAGA-Tad1 PF12767.2 CDF90844.1 - 1.6e-72 244.2 0.7 2.9e-72 243.3 0.0 1.7 1 1 1 2 2 2 1 Transcriptional regulator of RNA polII, SAGA, subunit TAF4 PF05236.9 CDF90844.1 - 0.0014 17.9 0.0 0.0028 17.0 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family TFIID_30kDa PF03540.8 CDF90844.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID 23-30kDa subunit BBP1_C PF15272.1 CDF90845.1 - 1.3e-58 197.8 22.0 1.3e-58 197.8 15.2 1.7 2 0 0 2 2 2 1 Spindle pole body component BBP1, C-terminal BBP1_N PF15271.1 CDF90845.1 - 8.7e-44 149.4 0.2 8.7e-44 149.4 0.1 2.8 2 1 1 3 3 3 1 Spindle pole body component BBP1, Mps2-binding protein YlqD PF11068.3 CDF90845.1 - 5.8 6.9 14.7 4.5 7.3 0.8 2.2 2 0 0 2 2 2 0 YlqD protein DUF1043 PF06295.7 CDF90845.1 - 9.7 5.8 13.3 14 5.3 7.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) Cyclin_N PF00134.18 CDF90847.1 - 2.9e-37 127.0 0.3 7.6e-37 125.7 0.0 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain RXT2_N PF08595.6 CDF90847.1 - 0.009 15.8 3.5 0.009 15.8 2.4 2.1 2 0 0 2 2 2 1 RXT2-like, N-terminal PBP1_TM PF14812.1 CDF90847.1 - 1.9 8.8 8.7 4.2 7.7 3.4 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Rot1 PF10681.4 CDF90848.1 - 1e-95 319.0 0.3 1.4e-95 318.6 0.2 1.2 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal VHS PF00790.14 CDF90849.1 - 1.2e-35 122.2 0.6 1.7e-34 118.4 0.0 2.2 2 0 0 2 2 2 1 VHS domain FYVE PF01363.16 CDF90849.1 - 2.1e-08 33.9 12.0 2.1e-08 33.9 8.3 2.7 2 1 0 2 2 2 1 FYVE zinc finger UIM PF02809.15 CDF90849.1 - 0.063 12.8 17.7 0.071 12.7 1.1 4.5 5 0 0 5 5 5 0 Ubiquitin interaction motif FliD_N PF02465.13 CDF90849.1 - 1.1 9.6 5.5 1 9.7 2.1 2.2 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus XPA_C PF05181.7 CDF90850.1 - 1.7e-26 91.5 0.6 2e-25 88.1 0.1 2.7 2 0 0 2 2 2 1 XPA protein C-terminus XPA_N PF01286.13 CDF90850.1 - 0.015 14.9 0.6 0.015 14.9 0.4 2.0 2 0 0 2 2 2 0 XPA protein N-terminal Myb_DNA-bind_3 PF12776.2 CDF90850.1 - 0.25 12.0 4.4 0.42 11.2 1.3 2.4 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Cas_Csy4 PF09618.5 CDF90850.1 - 1.7 8.4 7.1 1.6 8.4 1.1 2.3 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csy4) Autophagy_N PF03986.8 CDF90851.1 - 5.2e-43 146.3 0.8 5.2e-43 146.3 0.5 1.9 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.10 CDF90851.1 - 1.1e-21 76.7 1.3 2.2e-21 75.7 0.1 2.1 3 0 0 3 3 3 1 Autophagocytosis associated protein, active-site domain Autophagy_Cterm PF10381.4 CDF90851.1 - 1.9e-14 52.4 2.1 3.3e-14 51.6 1.5 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal RXT2_N PF08595.6 CDF90851.1 - 0.12 12.2 3.6 0.17 11.6 0.3 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal LCAT PF02450.10 CDF90852.1 - 3.4e-131 437.8 0.1 4.3e-131 437.4 0.1 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_5 PF12695.2 CDF90852.1 - 0.00055 19.7 0.0 0.001 18.8 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family YukC PF10140.4 CDF90852.1 - 0.0043 15.6 0.0 0.0085 14.7 0.0 1.4 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC DUF1749 PF08538.5 CDF90852.1 - 0.011 14.6 0.0 0.021 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Lipase_2 PF01674.13 CDF90852.1 - 0.012 14.9 0.0 0.023 14.0 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 2) Abhydrolase_6 PF12697.2 CDF90852.1 - 0.013 15.3 0.0 0.026 14.4 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDF90852.1 - 0.014 14.9 0.0 0.037 13.5 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF3292 PF11696.3 CDF90852.1 - 0.14 9.9 0.2 0.21 9.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF900 PF05990.7 CDF90852.1 - 0.15 11.3 0.0 0.26 10.5 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) BORA_N PF15280.1 CDF90852.1 - 0.19 11.0 0.1 0.19 11.0 0.0 1.7 2 0 0 2 2 2 0 Protein aurora borealis N-terminus Whi5 PF08528.6 CDF90853.1 - 4.5e-08 32.4 2.1 1e-07 31.3 1.5 1.7 1 0 0 1 1 1 1 Whi5 like SSP160 PF06933.6 CDF90853.1 - 0.22 9.4 5.9 0.3 9.0 4.1 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Dicty_REP PF05086.7 CDF90853.1 - 0.44 8.2 3.3 0.51 8.0 2.3 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein ERG2_Sigma1R PF04622.7 CDF90854.1 - 6.4e-92 306.6 1.6 7.8e-92 306.4 1.1 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein Med9 PF07544.8 CDF90855.1 - 1.4e-24 85.6 0.3 1.8e-24 85.2 0.2 1.1 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 DUF4200 PF13863.1 CDF90855.1 - 0.023 14.6 2.6 0.036 14.0 1.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Porin_3 PF01459.17 CDF90856.1 - 3.3e-81 272.5 0.4 3.8e-81 272.3 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic porin Acetyltransf_13 PF13880.1 CDF90856.1 - 0.05 13.3 0.0 0.099 12.3 0.0 1.5 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase PDZ PF00595.19 CDF90857.1 - 3e-07 30.5 0.2 6.7e-07 29.4 0.1 1.6 1 0 0 1 1 1 1 PDZ domain (Also known as DHR or GLGF) PDZ_2 PF13180.1 CDF90857.1 - 3.1e-06 26.9 0.4 6.9e-06 25.8 0.1 1.8 2 0 0 2 2 2 1 PDZ domain GRASP55_65 PF04495.9 CDF90857.1 - 4.5e-06 26.7 0.0 6.5e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain Trigger_C PF05698.9 CDF90857.1 - 0.0068 16.2 0.5 0.051 13.4 0.1 2.1 2 0 0 2 2 2 1 Bacterial trigger factor protein (TF) C-terminus Urm1 PF09138.6 CDF90858.1 - 1e-32 112.0 0.1 1.1e-32 111.9 0.1 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.15 CDF90858.1 - 0.002 18.5 0.1 0.0026 18.1 0.0 1.2 1 0 0 1 1 1 1 ThiS family HMGL-like PF00682.14 CDF90859.1 - 1.2e-66 224.7 0.0 2.3e-66 223.8 0.0 1.5 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.5 CDF90859.1 - 6.3e-19 68.0 0.0 1.3e-18 67.0 0.0 1.5 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain DUF3414 PF11894.3 CDF90860.1 - 0 1458.0 46.7 0 1457.9 32.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3414) Nsp1_C PF05064.8 CDF90861.1 - 3.8e-38 129.7 5.9 3.8e-38 129.7 4.1 2.2 1 1 1 2 2 2 1 Nsp1-like C-terminal region Laminin_II PF06009.7 CDF90861.1 - 0.26 11.0 16.4 0.74 9.5 6.3 2.9 1 1 2 3 3 3 0 Laminin Domain II Muted PF14942.1 CDF90861.1 - 1.7 8.5 5.6 0.89 9.4 1.9 1.9 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein RabGAP-TBC PF00566.13 CDF90863.1 - 1.1e-20 74.0 0.1 1.5e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain His_Phos_1 PF00300.17 CDF90864.1 - 2.3e-43 148.0 0.0 3.2e-43 147.5 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Carb_kinase PF01256.12 CDF90865.1 - 4.6e-69 232.3 0.0 1.3e-68 230.8 0.0 1.6 1 1 0 1 1 1 1 Carbohydrate kinase Phos_pyr_kin PF08543.7 CDF90865.1 - 0.00074 18.7 0.0 0.0012 18.1 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase NAD_binding_1 PF00175.16 CDF90866.1 - 1.2e-26 93.4 0.0 1.9e-26 92.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 CDF90866.1 - 1.9e-24 85.6 0.0 3e-24 84.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 CDF90866.1 - 1.6e-08 34.5 0.0 5.5e-06 26.3 0.0 2.4 1 1 0 2 2 2 2 Ferric reductase NAD binding domain Metallophos PF00149.23 CDF90867.1 - 3.4e-14 52.7 0.5 6e-14 51.9 0.3 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DBR1 PF05011.8 CDF90867.1 - 2.4e-11 43.6 0.0 5.4e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain FAD_binding_2 PF00890.19 CDF90868.1 - 2e-123 412.3 3.2 2.6e-123 411.9 2.2 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.15 CDF90868.1 - 2e-46 157.0 1.3 3.2e-46 156.3 0.9 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.9 CDF90868.1 - 1.5e-05 24.9 3.5 0.00027 20.8 0.0 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CDF90868.1 - 1.8e-05 23.8 3.0 0.00017 20.5 2.0 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.17 CDF90868.1 - 3.4e-05 22.8 1.9 0.0036 16.2 1.4 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.12 CDF90868.1 - 0.00014 21.0 0.2 0.0028 16.7 0.0 2.5 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.14 CDF90868.1 - 0.0057 15.7 2.0 0.026 13.5 0.1 2.6 3 0 0 3 3 3 1 FAD binding domain HI0933_like PF03486.9 CDF90868.1 - 0.028 12.8 0.5 0.11 10.9 0.1 2.1 3 0 0 3 3 3 0 HI0933-like protein NPL4 PF05021.10 CDF90869.1 - 2.5e-127 424.2 0.0 3.9e-127 423.6 0.0 1.3 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.10 CDF90869.1 - 4.6e-70 233.9 0.8 7.3e-70 233.3 0.5 1.3 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.3 CDF90869.1 - 2e-05 24.7 0.0 5.6e-05 23.3 0.0 1.8 1 1 0 1 1 1 1 Nuclear pore localisation protein NPL4 Sec66 PF09802.4 CDF90870.1 - 5.8e-74 247.5 3.6 6.7e-74 247.4 2.5 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 GYF PF02213.11 CDF90871.1 - 1e-19 69.8 2.1 1.6e-19 69.1 0.9 1.9 2 0 0 2 2 2 1 GYF domain UMP1 PF05348.6 CDF90872.1 - 1.2e-36 125.5 0.0 1.5e-36 125.2 0.0 1.0 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 WD40 PF00400.27 CDF90873.1 - 3.2e-30 102.8 15.1 3.6e-09 36.1 0.1 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.3 CDF90873.1 - 0.00017 19.9 0.2 0.15 10.2 0.0 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.11 CDF90873.1 - 0.0068 14.7 0.0 0.097 10.9 0.0 2.1 1 1 0 2 2 2 1 Cytochrome D1 heme domain Coatomer_WDAD PF04053.9 CDF90873.1 - 0.021 13.6 0.0 0.061 12.1 0.0 1.6 2 0 0 2 2 2 0 Coatomer WD associated region Hira PF07569.6 CDF90873.1 - 0.14 11.3 0.8 15 4.7 0.1 3.6 4 0 0 4 4 4 0 TUP1-like enhancer of split tRNA-synt_2 PF00152.15 CDF90874.1 - 1.5e-112 375.7 0.0 2e-112 375.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 CDF90874.1 - 5.6e-08 32.5 0.3 1.1e-07 31.5 0.2 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2b PF00587.20 CDF90874.1 - 0.00029 20.4 0.0 0.031 13.8 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2d PF01409.15 CDF90874.1 - 0.048 12.8 0.1 0.58 9.3 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) Pantoate_transf PF02548.10 CDF90875.1 - 3.7e-96 321.2 0.0 4.3e-96 321.0 0.0 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.1 CDF90875.1 - 0.00014 21.1 0.3 0.0003 20.0 0.1 1.6 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Lactamase_B_2 PF12706.2 CDF90876.1 - 1.8e-30 105.9 1.0 2.5e-30 105.4 0.7 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 CDF90876.1 - 8.1e-11 41.8 0.1 1.2e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain WD40 PF00400.27 CDF90877.1 - 4.8e-05 23.0 3.6 0.0073 16.1 0.1 4.5 5 0 0 5 5 5 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.9 CDF90877.1 - 0.13 11.0 0.2 0.25 10.0 0.1 1.4 1 1 0 1 1 1 0 Coatomer WD associated region Romo1 PF10247.4 CDF90879.1 - 4.4e-28 97.2 7.5 5.7e-28 96.9 5.2 1.2 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 tRNA-synt_1b PF00579.20 CDF90880.1 - 7.7e-71 238.5 0.0 1.2e-70 238.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Transglut_core PF01841.14 CDF90881.1 - 9.3e-11 41.9 0.0 1.8e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily Rad4 PF03835.10 CDF90881.1 - 3.8e-09 36.1 1.6 9.5e-09 34.8 1.1 1.7 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain DUF35_N PF12172.3 CDF90881.1 - 0.27 11.2 1.4 2 8.4 0.0 2.5 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Abhydrolase_1 PF00561.15 CDF90882.1 - 3.1e-24 85.8 0.0 5e-24 85.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CDF90882.1 - 1.1e-13 51.5 0.0 1.8e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CDF90882.1 - 3.4e-10 39.8 0.0 1.6e-09 37.7 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.6 CDF90882.1 - 0.0018 17.4 0.0 0.0099 14.9 0.0 2.1 2 1 1 3 3 3 1 Alpha/beta hydrolase of unknown function (DUF915) DUF676 PF05057.9 CDF90882.1 - 0.087 12.1 0.0 0.15 11.3 0.0 1.5 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Dynamin_N PF00350.18 CDF90883.1 - 7.1e-18 64.9 0.1 1.7e-17 63.7 0.1 1.7 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.18 CDF90883.1 - 2.8e-08 33.7 0.1 1.4e-07 31.4 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 CDF90883.1 - 1.1e-07 31.5 0.4 6.4e-07 28.9 0.3 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Miro PF08477.8 CDF90883.1 - 0.0037 17.7 0.4 0.11 13.0 0.0 2.9 2 1 1 3 3 3 1 Miro-like protein PduV-EutP PF10662.4 CDF90883.1 - 0.07 12.6 0.0 5.6 6.4 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_17 PF13207.1 CDF90883.1 - 0.085 13.6 0.8 12 6.7 0.0 3.3 3 1 0 3 3 3 0 AAA domain Sec62 PF03839.11 CDF90884.1 - 3.3e-61 206.5 0.1 4.1e-61 206.2 0.1 1.1 1 0 0 1 1 1 1 Translocation protein Sec62 MARVEL PF01284.18 CDF90884.1 - 0.00045 20.0 0.2 0.0006 19.6 0.1 1.2 1 0 0 1 1 1 1 Membrane-associating domain HTH_36 PF13730.1 CDF90884.1 - 0.11 12.6 0.0 0.34 11.0 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain MFS_1 PF07690.11 CDF90885.1 - 1.1e-49 169.1 44.9 3.4e-45 154.2 16.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CDF90885.1 - 7e-17 61.1 26.9 4.4e-16 58.5 4.0 2.9 3 0 0 3 3 3 2 Sugar (and other) transporter SLAC1 PF03595.12 CDF90886.1 - 8.8e-71 238.2 32.3 1e-70 238.0 22.4 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel UL2 PF08196.6 CDF90886.1 - 0.06 13.0 3.3 7.8 6.3 0.2 2.9 2 0 0 2 2 2 0 UL2 protein Pyr_redox_2 PF07992.9 CDF90887.1 - 2.5e-42 145.0 0.0 6.9e-42 143.6 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 CDF90887.1 - 2.2e-38 130.6 1.1 2.3e-35 120.9 0.1 3.2 3 1 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 CDF90887.1 - 2.5e-20 72.6 7.2 1.9e-19 69.8 0.7 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CDF90887.1 - 2.8e-11 43.8 0.4 6.5e-08 32.8 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CDF90887.1 - 6.3e-08 31.5 9.1 0.015 13.7 0.1 4.0 3 1 1 4 4 4 3 HI0933-like protein FAD_oxidored PF12831.2 CDF90887.1 - 4e-07 29.4 0.4 1.4e-06 27.6 0.1 1.7 1 1 0 2 2 2 1 FAD dependent oxidoreductase K_oxygenase PF13434.1 CDF90887.1 - 2e-06 26.9 0.0 3.8e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.17 CDF90887.1 - 6.9e-06 25.1 3.7 0.00032 19.6 1.0 2.5 2 0 0 2 2 2 2 Glucose inhibited division protein A AlaDh_PNT_C PF01262.16 CDF90887.1 - 2e-05 24.2 0.6 0.0035 16.9 0.1 2.5 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.13 CDF90887.1 - 0.00019 21.1 4.4 0.00019 21.1 0.1 2.4 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.14 CDF90887.1 - 0.0019 17.3 2.0 0.12 11.4 0.0 3.1 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DAO PF01266.19 CDF90887.1 - 0.0078 15.1 2.3 0.0078 15.1 1.6 3.9 3 1 1 4 4 4 1 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.9 CDF90887.1 - 0.0093 15.3 0.1 0.027 13.8 0.1 1.9 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_Gly3P_dh_N PF01210.18 CDF90887.1 - 0.0094 15.6 2.2 0.053 13.2 0.1 2.6 2 1 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_7 PF13241.1 CDF90887.1 - 0.044 14.0 0.4 3.5 7.9 0.0 2.8 2 1 0 2 2 2 0 Putative NAD(P)-binding FAD_binding_2 PF00890.19 CDF90887.1 - 0.13 11.0 8.9 0.17 10.7 2.0 3.1 4 0 0 4 4 4 0 FAD binding domain FAD_binding_3 PF01494.14 CDF90887.1 - 1.6 7.6 8.1 6.4 5.7 0.3 2.5 2 1 0 2 2 2 0 FAD binding domain Ribosomal_S6e PF01092.14 CDF90888.1 - 1.3e-63 212.2 0.5 2.6e-63 211.3 0.3 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e DUP PF00674.13 CDF90889.1 - 0.0089 15.9 0.1 0.0089 15.9 0.1 2.1 2 1 0 2 2 2 1 DUP family CRCB PF02537.10 CDF90890.1 - 8.1e-24 83.7 16.4 2.8e-13 49.7 4.1 2.6 2 0 0 2 2 2 2 CrcB-like protein DUF4131 PF13567.1 CDF90890.1 - 0.027 13.8 7.6 0.091 12.1 3.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF389 PF04087.9 CDF90890.1 - 0.052 13.5 0.5 0.052 13.5 0.4 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF389) SRF-TF PF00319.13 CDF90891.1 - 8.1e-24 82.6 0.0 1.2e-23 82.0 0.0 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) GATA PF00320.22 CDF90893.1 - 3.5e-17 61.4 2.6 6.9e-17 60.5 1.8 1.5 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.5 CDF90893.1 - 7.1e-11 41.4 2.0 1.4e-10 40.5 1.4 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) DUF2572 PF10833.3 CDF90893.1 - 0.053 12.9 1.8 0.11 11.9 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) Pyr_redox_dim PF02852.17 CDF90894.1 - 5.5e-42 142.2 0.1 1.6e-41 140.7 0.1 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.9 CDF90894.1 - 2.6e-40 138.4 11.2 6.6e-38 130.6 7.8 3.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CDF90894.1 - 1.7e-21 76.4 10.8 2.7e-19 69.3 0.4 3.9 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 CDF90894.1 - 3.3e-14 52.8 3.8 1.1e-11 44.4 0.1 2.8 2 1 1 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 CDF90894.1 - 1.4e-09 38.3 0.2 7.1e-07 29.4 0.0 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CDF90894.1 - 1e-08 35.0 4.4 0.00071 19.5 1.1 3.2 2 1 1 3 3 3 2 NAD(P)-binding Rossmann-like domain GIDA PF01134.17 CDF90894.1 - 2.3e-08 33.3 7.5 3.5e-07 29.4 4.2 2.8 1 1 1 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.19 CDF90894.1 - 1.2e-07 30.9 9.7 2.6e-07 29.8 1.5 2.9 2 1 1 3 3 3 1 FAD binding domain DAO PF01266.19 CDF90894.1 - 6.4e-06 25.3 13.6 0.0045 15.9 1.1 4.2 2 2 2 4 4 4 3 FAD dependent oxidoreductase HI0933_like PF03486.9 CDF90894.1 - 7.5e-06 24.6 11.2 0.00026 19.5 0.7 4.0 3 1 1 4 4 4 1 HI0933-like protein Thi4 PF01946.12 CDF90894.1 - 0.0001 21.5 0.7 0.0035 16.4 0.0 2.5 2 0 0 2 2 2 1 Thi4 family AlaDh_PNT_C PF01262.16 CDF90894.1 - 0.00011 21.8 0.7 0.019 14.5 0.0 2.4 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.14 CDF90894.1 - 0.00015 20.9 9.5 0.019 14.0 0.6 3.6 2 1 0 2 2 2 2 FAD binding domain K_oxygenase PF13434.1 CDF90894.1 - 0.0027 16.6 0.7 2.6 6.8 0.0 2.9 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) 3HCDH_N PF02737.13 CDF90894.1 - 0.044 13.4 0.1 0.044 13.4 0.1 2.7 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.7 CDF90894.1 - 0.6 8.9 2.4 1.7 7.4 0.5 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein Trp_halogenase PF04820.9 CDF90894.1 - 8 4.9 6.0 1.2 7.6 0.4 2.2 2 1 0 2 2 2 0 Tryptophan halogenase zf-C2H2 PF00096.21 CDF90895.1 - 1.2e-13 50.4 37.4 0.00041 20.5 1.2 5.3 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CDF90895.1 - 1.4e-10 40.7 36.1 0.0027 17.9 1.3 5.3 5 0 0 5 5 5 4 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CDF90895.1 - 4.4e-06 26.7 8.2 8.8e-05 22.6 0.1 6.1 7 0 0 7 7 7 4 Zinc-finger double domain zf-met PF12874.2 CDF90895.1 - 0.29 11.4 11.8 5 7.4 0.3 4.9 5 0 0 5 5 5 0 Zinc-finger of C2H2 type Abhydrolase_6 PF12697.2 CDF90896.1 - 2.8e-27 96.0 0.0 3.4e-27 95.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDF90896.1 - 1.3e-16 60.9 0.0 1.6e-16 60.6 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 CDF90896.1 - 1.5e-10 41.0 0.0 2.8e-10 40.1 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 CDF90896.1 - 6.6e-05 22.6 0.0 0.00016 21.4 0.0 1.7 1 0 0 1 1 1 1 Putative lysophospholipase Abhydrolase_4 PF08386.5 CDF90896.1 - 0.0049 16.7 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein FSH1 PF03959.8 CDF90896.1 - 0.011 15.2 0.0 1.2 8.5 0.0 2.3 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Chlorophyllase2 PF12740.2 CDF90896.1 - 0.098 11.5 0.0 0.15 10.8 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme LSM PF01423.17 CDF90897.1 - 2.2e-14 52.7 0.1 2.5e-14 52.5 0.1 1.1 1 0 0 1 1 1 1 LSM domain Acetyltransf_1 PF00583.19 CDF90898.1 - 7.7e-15 54.6 0.0 1.1e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 CDF90898.1 - 3.8e-11 42.9 0.0 5.5e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 CDF90898.1 - 9.2e-06 25.5 0.0 1.5e-05 24.8 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 CDF90898.1 - 4.1e-05 23.6 0.0 4.9e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 CDF90898.1 - 0.0027 17.6 0.0 0.0028 17.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 CDF90898.1 - 0.037 13.9 0.0 0.063 13.1 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 CDF90898.1 - 0.059 13.2 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase FR47 PF08445.5 CDF90898.1 - 0.12 12.1 0.0 0.24 11.2 0.0 1.5 1 1 0 1 1 1 0 FR47-like protein DUF2781 PF10914.3 CDF90900.1 - 8.1e-31 106.8 4.7 9.5e-31 106.6 3.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) DUF411 PF04214.8 CDF90900.1 - 0.14 11.6 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF DnaJ PF00226.26 CDF90901.1 - 3.6e-24 84.2 3.9 6.5e-24 83.4 2.7 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 CDF90901.1 - 4.3e-22 77.8 0.2 5.7e-16 58.1 0.1 3.2 3 0 0 3 3 3 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 CDF90901.1 - 1e-11 44.7 21.2 1.7e-11 43.9 14.7 1.4 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.14 CDF90901.1 - 0.0015 18.2 7.2 0.0066 16.1 1.2 2.3 1 1 1 2 2 2 1 Hydrogenase expression/synthesis hypA family Cytochrom_c3_2 PF14537.1 CDF90901.1 - 0.052 13.8 10.9 0.14 12.5 7.6 1.7 1 0 0 1 1 1 0 Cytochrome c3 FecR PF04773.8 CDF90901.1 - 0.088 13.0 0.0 1.2 9.3 0.0 2.3 2 0 0 2 2 2 0 FecR protein A2L_zn_ribbon PF08792.5 CDF90901.1 - 0.17 11.3 0.1 0.17 11.3 0.1 3.8 4 0 0 4 4 4 0 A2L zinc ribbon domain Cytochrome_C7 PF14522.1 CDF90901.1 - 0.25 11.0 14.4 0.72 9.5 10.0 1.8 1 1 0 1 1 1 0 Cytochrome c7 Paired_CXXCH_1 PF09699.5 CDF90901.1 - 5.8 6.5 10.4 5.4 6.6 5.7 2.2 1 1 1 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) S-antigen PF05756.6 CDF90901.1 - 9.2 6.3 5.9 0.59 10.1 0.6 1.6 2 0 0 2 2 2 0 S-antigen protein D-ser_dehydrat PF14031.1 CDF90902.1 - 1.4e-20 73.2 0.0 5.2e-19 68.2 0.0 2.9 3 0 0 3 3 3 1 Putative serine dehydratase domain Ala_racemase_N PF01168.15 CDF90902.1 - 8.1e-10 38.6 0.0 1.2e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain HSP9_HSP12 PF04119.7 CDF90903.1 - 2.6e-24 85.0 5.8 2.6e-24 85.0 4.0 2.1 2 0 0 2 2 2 1 Heat shock protein 9/12 DUF1771 PF08590.5 CDF90903.1 - 0.0097 15.9 1.0 0.31 11.0 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) YtxH PF12732.2 CDF90903.1 - 0.012 15.9 7.3 0.082 13.2 0.5 2.3 1 1 1 2 2 2 0 YtxH-like protein Apolipoprotein PF01442.13 CDF90903.1 - 0.033 13.6 0.2 0.045 13.2 0.1 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain ApoA-II PF04711.8 CDF90903.1 - 0.055 13.3 0.6 4.6 7.1 0.1 2.1 2 0 0 2 2 2 0 Apolipoprotein A-II (ApoA-II) Tape_meas_lam_C PF09718.5 CDF90903.1 - 0.11 12.3 0.2 0.25 11.2 0.1 1.7 2 0 0 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) DUF883 PF05957.8 CDF90903.1 - 0.12 12.7 1.9 1.5 9.3 0.5 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF4337 PF14235.1 CDF90903.1 - 3.2 7.5 6.1 3.2 7.5 3.5 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) MT0933_antitox PF14013.1 CDF90903.1 - 8.8 6.5 7.1 37 4.5 0.0 3.2 1 1 1 2 2 2 0 MT0933-like antitoxin protein bZIP_1 PF00170.16 CDF90904.1 - 0.11 12.5 6.7 0.17 11.8 1.7 2.4 2 0 0 2 2 2 0 bZIP transcription factor GAGA_bind PF06217.7 CDF90905.1 - 9.7 6.0 12.3 5.4 6.8 4.9 2.2 2 0 0 2 2 2 0 GAGA binding protein-like family WW PF00397.21 CDF90906.1 - 2e-09 37.1 1.5 3.4e-09 36.4 1.0 1.4 1 0 0 1 1 1 1 WW domain PAT1 PF09770.4 CDF90906.1 - 7.5 4.6 12.9 9.1 4.3 8.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DAO PF01266.19 CDF90907.1 - 3.8e-20 72.1 0.0 5.4e-19 68.3 0.0 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase DUF202 PF02656.10 CDF90909.1 - 0.41 10.9 3.2 11 6.3 2.2 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF202) SMC_N PF02463.14 CDF90910.1 - 5.3e-52 176.2 44.5 7.2e-51 172.5 30.9 2.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.8 CDF90910.1 - 4e-25 88.1 1.0 8.7e-25 87.0 0.0 2.2 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.1 CDF90910.1 - 1.7e-17 64.4 12.4 1.7e-17 64.4 8.6 6.7 3 2 1 4 4 4 1 AAA domain AAA_21 PF13304.1 CDF90910.1 - 1.8e-09 38.0 24.0 4.4e-06 26.8 4.1 3.7 2 1 1 3 3 3 2 AAA domain AAA_29 PF13555.1 CDF90910.1 - 1.5e-07 30.8 0.1 3.1e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Octopine_DH PF02317.12 CDF90910.1 - 2.1 8.0 6.9 4 7.0 0.0 3.7 3 0 0 3 3 3 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain DUF3437 PF11919.3 CDF90911.1 - 2.4e-29 100.8 0.1 1.6e-28 98.2 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3437) DUF1546 PF07571.8 CDF90911.1 - 0.038 14.0 0.0 0.12 12.4 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1546) HEAT PF02985.17 CDF90911.1 - 0.043 13.9 0.0 4.6 7.5 0.0 3.1 2 0 0 2 2 2 0 HEAT repeat Ras PF00071.17 CDF90912.1 - 4.6e-64 214.6 0.3 5.7e-64 214.3 0.2 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDF90912.1 - 3.9e-19 69.3 0.1 3.9e-19 69.3 0.0 1.6 2 0 0 2 2 1 1 Miro-like protein Arf PF00025.16 CDF90912.1 - 7.9e-19 67.5 0.1 9.7e-19 67.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 CDF90912.1 - 2.4e-07 30.1 0.1 2.4e-07 30.1 0.0 1.4 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 CDF90912.1 - 2.5e-07 30.0 0.1 3.2e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.22 CDF90912.1 - 3.3e-06 26.6 0.2 3.8e-05 23.1 0.1 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CDF90912.1 - 1.3e-05 25.1 0.1 2.2e-05 24.3 0.1 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF258 PF03193.11 CDF90912.1 - 5.1e-05 22.5 0.2 0.039 13.1 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 FeoB_N PF02421.13 CDF90912.1 - 0.00094 18.4 0.1 0.02 14.2 0.1 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_29 PF13555.1 CDF90912.1 - 0.0017 17.8 4.2 0.15 11.6 0.9 3.2 3 1 1 4 4 4 1 P-loop containing region of AAA domain AAA_22 PF13401.1 CDF90912.1 - 0.0038 17.3 0.1 0.018 15.1 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.1 CDF90912.1 - 0.0051 16.8 0.5 0.018 15.0 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain MCM PF00493.18 CDF90912.1 - 0.031 13.0 0.0 0.062 12.0 0.0 1.4 1 0 0 1 1 1 0 MCM2/3/5 family AAA PF00004.24 CDF90912.1 - 0.033 14.3 0.0 0.74 10.0 0.0 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) G-alpha PF00503.15 CDF90912.1 - 0.066 11.8 0.9 0.99 8.0 0.0 2.5 1 1 1 2 2 2 0 G-protein alpha subunit DUF815 PF05673.8 CDF90912.1 - 0.072 12.0 0.1 0.3 9.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF815) PduV-EutP PF10662.4 CDF90912.1 - 0.084 12.3 0.0 0.21 11.0 0.0 2.0 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Sigma54_activat PF00158.21 CDF90912.1 - 0.11 11.9 0.0 2.1 7.7 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain ABC_tran PF00005.22 CDF90912.1 - 3.1 8.1 5.7 0.96 9.7 0.2 2.6 1 1 0 2 2 2 0 ABC transporter VTC PF09359.5 CDF90913.1 - 1.9e-93 312.5 2.2 1.9e-93 312.5 1.5 1.9 2 0 0 2 2 2 1 VTC domain SPX PF03105.14 CDF90913.1 - 1.2e-24 87.5 31.4 6.8e-17 62.1 0.7 3.8 3 1 1 4 4 4 2 SPX domain DUF202 PF02656.10 CDF90913.1 - 1.2e-10 41.4 2.0 2.9e-10 40.1 1.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF202) DUF4149 PF13664.1 CDF90913.1 - 0.00045 20.2 1.7 0.00082 19.3 1.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4149) Rod_cone_degen PF15201.1 CDF90913.1 - 0.02 14.7 0.2 0.052 13.3 0.2 1.6 1 0 0 1 1 1 0 Progressive rod-cone degeneration DUF2975 PF11188.3 CDF90913.1 - 0.23 11.2 2.2 0.4 10.4 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) Peptidase_C48 PF02902.14 CDF90914.1 - 2.8e-39 135.0 0.1 2.8e-39 135.0 0.0 2.2 2 1 1 3 3 3 1 Ulp1 protease family, C-terminal catalytic domain LMBR1 PF04791.11 CDF90914.1 - 0.078 11.5 0.4 0.2 10.2 0.0 1.6 1 1 1 2 2 2 0 LMBR1-like membrane protein SIR2 PF02146.12 CDF90915.1 - 2.6e-53 180.3 0.0 3.5e-53 179.9 0.0 1.2 1 0 0 1 1 1 1 Sir2 family DUF3441 PF11923.3 CDF90916.1 - 7.1e-34 115.7 0.6 7.1e-34 115.7 0.4 3.3 3 1 0 3 3 3 1 Domain of unknown function (DUF3441) FbpA PF05833.6 CDF90916.1 - 5.4e-24 84.5 0.0 5.4e-24 84.5 0.0 3.6 3 2 0 3 3 3 2 Fibronectin-binding protein A N-terminus (FbpA) DUF814 PF05670.8 CDF90916.1 - 2.5e-09 36.8 0.0 8.4e-09 35.2 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF814) Clat_adaptor_s PF01217.15 CDF90917.1 - 2e-16 59.9 0.7 1.1e-15 57.5 0.5 1.8 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Bromo_TP PF07524.8 CDF90918.1 - 2.7e-06 27.0 0.0 5.4e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Bromodomain associated NUC173 PF08161.7 CDF90919.1 - 2e-72 242.7 0.2 4.2e-71 238.4 0.1 2.7 3 0 0 3 3 3 1 NUC173 domain HEAT PF02985.17 CDF90919.1 - 0.0054 16.7 0.8 16 5.8 0.0 4.6 4 0 0 4 4 4 2 HEAT repeat Inh PF02974.9 CDF90919.1 - 0.077 12.5 0.1 0.4 10.2 0.0 2.2 2 0 0 2 2 2 0 Protease inhibitor Inh Ribosomal_S16 PF00886.14 CDF90920.1 - 5.9e-24 83.5 0.1 7.7e-24 83.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S16 PDR_assoc PF08370.6 CDF90920.1 - 0.14 11.6 0.0 0.31 10.5 0.0 1.5 1 0 0 1 1 1 0 Plant PDR ABC transporter associated PriCT_1 PF08708.6 CDF90921.1 - 0.07 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Primase C terminal 1 (PriCT-1) Helicase_C_2 PF13307.1 CDF90922.1 - 6.8e-49 166.0 0.0 1.4e-48 164.9 0.0 1.5 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.10 CDF90922.1 - 9.6e-49 165.1 0.0 1.7e-48 164.3 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.24 CDF90922.1 - 0.00018 21.0 0.0 0.046 13.2 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.10 CDF90922.1 - 0.00021 21.1 0.0 0.24 11.1 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_22 PF13401.1 CDF90922.1 - 0.0037 17.3 0.3 0.88 9.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CDF90922.1 - 0.0042 16.8 0.1 0.02 14.6 0.1 2.1 2 0 0 2 2 2 1 Part of AAA domain PhoH PF02562.11 CDF90922.1 - 0.042 13.0 0.3 5 6.3 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein Patched PF02460.13 CDF90923.1 - 5.3e-55 186.7 33.5 9.5e-52 175.9 23.2 3.1 1 1 0 1 1 1 1 Patched family Sterol-sensing PF12349.3 CDF90923.1 - 6.5e-39 132.8 5.6 6.5e-39 132.8 3.9 2.5 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.10 CDF90923.1 - 2.2e-06 26.6 20.6 5.3e-06 25.3 0.9 2.2 2 0 0 2 2 2 2 MMPL family PPR_2 PF13041.1 CDF90924.1 - 1.2e-15 57.1 1.8 1.7e-06 27.9 0.1 4.8 4 1 1 5 5 5 3 PPR repeat family PPR_3 PF13812.1 CDF90924.1 - 0.00011 22.1 0.2 19 5.8 0.0 5.0 4 0 0 4 4 4 2 Pentatricopeptide repeat domain PPR_1 PF12854.2 CDF90924.1 - 0.00051 19.4 0.0 0.81 9.2 0.1 4.4 4 0 0 4 4 4 1 PPR repeat PPR PF01535.15 CDF90924.1 - 0.3 11.1 1.8 89 3.3 0.1 4.7 5 0 0 5 5 5 0 PPR repeat Pil1 PF13805.1 CDF90925.1 - 3.1e-153 508.6 0.3 3.7e-153 508.3 0.2 1.0 1 0 0 1 1 1 1 Eisosome component PIL1 PCP_red PF08369.5 CDF90925.1 - 0.05 13.4 4.6 0.13 12.1 0.1 2.9 3 0 0 3 3 3 0 Proto-chlorophyllide reductase 57 kD subunit DEAD PF00270.24 CDF90927.1 - 1.7e-36 125.2 0.0 3.7e-36 124.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF90927.1 - 3.1e-20 71.8 0.0 1.8e-19 69.3 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.1 CDF90927.1 - 3.5e-16 58.4 0.2 9.6e-16 57.0 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.10 CDF90927.1 - 8e-05 22.5 1.5 0.00056 19.7 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.16 CDF90927.1 - 0.00055 19.3 2.8 0.018 14.3 0.0 2.2 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain PseudoU_synth_1 PF01416.15 CDF90928.1 - 4.7e-29 100.8 0.0 2.4e-18 66.4 0.0 2.9 3 0 0 3 3 3 2 tRNA pseudouridine synthase EAP30 PF04157.11 CDF90929.1 - 1.9e-52 177.6 0.0 2.1e-52 177.4 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family RILP PF11461.3 CDF90929.1 - 0.078 13.1 0.1 0.16 12.1 0.1 1.5 1 0 0 1 1 1 0 Rab interacting lysosomal protein Mga PF05043.8 CDF90929.1 - 0.098 12.9 0.1 0.47 10.7 0.0 2.1 2 0 0 2 2 2 0 Mga helix-turn-helix domain Hat1_N PF10394.4 CDF90930.1 - 4.3e-37 127.6 4.1 4.3e-37 127.6 2.8 2.0 2 1 1 3 3 3 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.19 CDF90930.1 - 0.0037 17.2 0.0 0.008 16.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 CDF90930.1 - 0.035 14.2 0.0 0.071 13.2 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Citrate_synt PF00285.16 CDF90932.1 - 5.4e-92 308.2 0.0 6.3e-92 308.0 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase MmgE_PrpD PF03972.9 CDF90933.1 - 1.2e-159 531.2 0.0 1.3e-159 531.1 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family Nic96 PF04097.9 CDF90934.1 - 5.2e-211 701.9 16.3 6.8e-211 701.6 11.3 1.1 1 0 0 1 1 1 1 Nup93/Nic96 PPI_Ypi1 PF07491.6 CDF90935.1 - 1.3e-23 82.3 10.3 3.7e-23 80.8 7.1 1.8 1 1 0 1 1 1 1 Protein phosphatase inhibitor Cwf_Cwc_15 PF04889.7 CDF90935.1 - 0.0057 16.4 5.9 0.0077 15.9 4.1 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein YL1 PF05764.8 CDF90935.1 - 0.014 15.0 3.7 0.017 14.7 2.6 1.2 1 0 0 1 1 1 0 YL1 nuclear protein SR-25 PF10500.4 CDF90935.1 - 0.16 11.3 14.6 0.24 10.8 10.1 1.3 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein CDC45 PF02724.9 CDF90935.1 - 1.1 7.2 7.8 1.3 7.0 5.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Neur_chan_memb PF02932.11 CDF90935.1 - 5.2 6.8 7.5 10 5.9 5.2 1.5 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region JAB PF01398.16 CDF90936.1 - 6.5e-33 112.8 1.1 8.1e-33 112.5 0.1 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.1 CDF90936.1 - 2.2e-25 88.9 6.1 5.6e-25 87.6 4.2 1.7 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.1 CDF90936.1 - 1.1e-08 34.6 0.0 1.8e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.8 CDF90936.1 - 0.044 13.2 1.8 0.57 9.6 0.0 2.3 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0172) zf-UBP PF02148.14 CDF90937.1 - 2.6e-10 40.2 2.0 5.9e-10 39.1 1.4 1.5 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH PF00443.24 CDF90937.1 - 2.1e-08 33.5 0.7 4.1e-08 32.6 0.5 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_M24 PF00557.19 CDF90938.1 - 1.2e-56 191.6 0.0 1.5e-56 191.3 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.11 CDF90938.1 - 6.8e-24 83.7 0.1 5.1e-23 80.9 0.0 2.4 3 0 0 3 3 3 1 Aminopeptidase P, N-terminal domain Rad21_Rec8_N PF04825.8 CDF90940.1 - 2.6e-17 62.7 0.0 6.7e-17 61.4 0.0 1.7 1 1 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Nterm_IS4 PF13006.2 CDF90940.1 - 0.028 14.4 0.0 0.06 13.3 0.0 1.5 1 0 0 1 1 1 0 Insertion element 4 transposase N-terminal ICL PF00463.16 CDF90941.1 - 4.7e-171 569.5 0.0 5.4e-171 569.3 0.0 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.1 CDF90941.1 - 1.6e-08 34.1 0.0 3.9e-08 32.8 0.0 1.6 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase AAA_18 PF13238.1 CDF90943.1 - 7.1e-08 32.8 0.1 2.5e-05 24.5 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.1 CDF90943.1 - 1.4e-07 31.4 0.0 0.023 14.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 CDF90943.1 - 3.8e-07 30.9 0.0 3.4e-06 27.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 CDF90943.1 - 0.00052 20.1 0.0 0.0038 17.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CDF90943.1 - 0.00083 19.3 0.0 0.0017 18.3 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain PRK PF00485.13 CDF90943.1 - 0.00091 18.8 0.0 0.15 11.5 0.0 2.3 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_5 PF07728.9 CDF90943.1 - 0.001 18.7 0.0 0.0032 17.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA PF00004.24 CDF90943.1 - 0.0017 18.5 0.0 0.0043 17.2 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.17 CDF90943.1 - 0.002 18.2 0.0 0.005 16.9 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_25 PF13481.1 CDF90943.1 - 0.0027 17.1 0.0 0.12 11.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 CDF90943.1 - 0.0034 16.5 0.0 0.0066 15.5 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin DUF402 PF04167.8 CDF90943.1 - 0.0078 16.0 0.6 0.41 10.5 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF402) ABC_tran PF00005.22 CDF90943.1 - 0.0092 16.2 0.0 0.025 14.8 0.0 1.8 2 0 0 2 2 2 1 ABC transporter NB-ARC PF00931.17 CDF90943.1 - 0.01 14.6 0.0 0.024 13.5 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_23 PF13476.1 CDF90943.1 - 0.021 15.1 0.0 0.62 10.3 0.0 2.2 2 1 0 2 2 2 0 AAA domain NACHT PF05729.7 CDF90943.1 - 0.028 14.0 0.0 0.086 12.4 0.0 1.8 1 0 0 1 1 1 0 NACHT domain Rad17 PF03215.10 CDF90943.1 - 0.035 12.7 0.0 0.057 12.1 0.0 1.3 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein MMR_HSR1 PF01926.18 CDF90943.1 - 0.041 13.8 0.0 0.11 12.5 0.0 1.7 2 0 0 2 2 1 0 50S ribosome-binding GTPase Sigma54_activ_2 PF14532.1 CDF90943.1 - 0.042 13.9 0.0 1.4 8.9 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_28 PF13521.1 CDF90943.1 - 0.047 13.6 0.0 0.15 12.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.12 CDF90943.1 - 0.068 12.5 0.0 0.16 11.3 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF2075 PF09848.4 CDF90943.1 - 0.073 12.0 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_29 PF13555.1 CDF90943.1 - 0.074 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain MobB PF03205.9 CDF90943.1 - 0.087 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B KTI12 PF08433.5 CDF90943.1 - 0.089 11.9 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_10 PF12846.2 CDF90943.1 - 0.094 12.1 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain ArgK PF03308.11 CDF90943.1 - 0.097 11.4 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 ArgK protein NTPase_1 PF03266.10 CDF90943.1 - 0.11 12.2 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 NTPase PPV_E1_C PF00519.12 CDF90943.1 - 0.12 11.0 0.0 0.17 10.4 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase AAA_14 PF13173.1 CDF90943.1 - 0.14 12.0 0.0 0.61 9.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain ETF PF01012.16 CDF90944.1 - 4.7e-35 120.7 0.1 8.2e-35 119.9 0.1 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.14 CDF90944.1 - 1.6e-34 117.3 0.1 3.8e-34 116.1 0.1 1.7 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain Sulfate_transp PF00916.15 CDF90945.1 - 3.5e-62 209.9 6.8 3.5e-62 209.9 4.7 1.6 2 0 0 2 2 2 1 Sulfate transporter family Sulfate_tra_GLY PF13792.1 CDF90945.1 - 5.1e-28 96.5 4.5 9.5e-28 95.6 2.3 2.2 2 0 0 2 2 2 1 Sulfate transporter N-terminal domain with GLY motif STAS PF01740.16 CDF90945.1 - 2.9e-24 84.7 0.0 5.5e-24 83.8 0.0 1.4 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.1 CDF90945.1 - 1.9e-05 24.6 0.0 5e-05 23.2 0.0 1.8 1 1 0 1 1 1 1 STAS domain Spore_YabQ PF09578.5 CDF90945.1 - 4.9 7.1 11.6 1.1 9.2 0.9 2.9 3 0 0 3 3 3 0 Spore cortex protein YabQ (Spore_YabQ) Copper-fist PF00649.13 CDF90947.1 - 3.8e-22 77.1 0.9 3.8e-22 77.1 0.7 2.5 1 1 1 2 2 2 1 Copper fist DNA binding domain Ran-binding PF05508.6 CDF90948.1 - 1.8e-111 371.9 5.5 1.8e-111 371.9 3.8 1.7 2 1 0 2 2 2 1 RanGTP-binding protein Nop14 PF04147.7 CDF90948.1 - 0.0016 16.4 12.2 0.0016 16.4 8.5 2.0 2 0 0 2 2 2 1 Nop14-like family NOA36 PF06524.7 CDF90948.1 - 0.01 15.1 7.8 0.015 14.5 5.4 1.2 1 0 0 1 1 1 0 NOA36 protein Noelin-1 PF12308.3 CDF90948.1 - 0.022 14.5 1.2 0.093 12.5 0.1 2.2 2 0 0 2 2 2 0 Neurogenesis glycoprotein CDC45 PF02724.9 CDF90948.1 - 0.057 11.4 11.2 0.1 10.6 7.7 1.4 1 0 0 1 1 1 0 CDC45-like protein VID27 PF08553.5 CDF90948.1 - 0.085 11.0 18.2 0.43 8.7 0.1 2.3 2 0 0 2 2 2 0 VID27 cytoplasmic protein CENP-B_dimeris PF09026.5 CDF90948.1 - 0.23 11.6 19.0 0.95 9.7 13.1 2.1 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Daxx PF03344.10 CDF90948.1 - 0.35 9.3 16.6 0.52 8.7 11.5 1.2 1 0 0 1 1 1 0 Daxx Family Prog_receptor PF02161.10 CDF90948.1 - 0.4 9.4 3.3 0.63 8.8 2.3 1.2 1 0 0 1 1 1 0 Progesterone receptor PBP1_TM PF14812.1 CDF90948.1 - 0.5 10.6 22.3 3.2 8.1 15.5 2.4 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sigma70_ner PF04546.8 CDF90948.1 - 0.89 9.1 19.0 0.043 13.4 8.0 2.4 3 0 0 3 3 3 0 Sigma-70, non-essential region TRAP_alpha PF03896.11 CDF90948.1 - 1.6 7.6 11.4 3 6.7 7.9 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Tom37_C PF11801.3 CDF90948.1 - 2.7 7.8 8.8 0.47 10.3 2.8 2.0 2 0 0 2 2 2 0 Tom37 C-terminal domain DUF2457 PF10446.4 CDF90948.1 - 3.1 6.4 27.1 5.5 5.6 18.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Spt5_N PF11942.3 CDF90948.1 - 4.7 7.8 27.1 1.8 9.2 15.2 2.6 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal FAM176 PF14851.1 CDF90948.1 - 5.2 6.7 9.3 13 5.4 6.4 1.7 1 0 0 1 1 1 0 FAM176 family SDA1 PF05285.7 CDF90948.1 - 7.5 5.7 22.2 0.11 11.7 10.2 1.7 2 0 0 2 2 2 0 SDA1 SNF2_N PF00176.18 CDF90949.1 - 1.2e-71 240.9 0.0 1.8e-71 240.4 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.5 CDF90949.1 - 4.7e-50 170.1 1.8 3.5e-49 167.2 1.1 2.1 2 0 0 2 2 2 1 Rad54 N terminal Helicase_C PF00271.26 CDF90949.1 - 1.3e-12 47.3 0.0 3.3e-12 46.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 CDF90949.1 - 3.8e-10 39.0 0.0 2.4e-09 36.4 0.0 2.3 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.24 CDF90949.1 - 0.0001 21.8 0.0 0.00025 20.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 CDF90949.1 - 0.0058 16.4 0.0 0.013 15.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_12 PF13087.1 CDF90949.1 - 0.0066 15.8 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zn_clus PF00172.13 CDF90951.1 - 0.001 18.9 1.6 0.001 18.9 1.1 2.4 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Macoilin PF09726.4 CDF90951.1 - 3.6 5.7 7.9 4.6 5.3 5.5 1.1 1 0 0 1 1 1 0 Transmembrane protein Yip1 PF04893.12 CDF90952.1 - 0.00015 21.3 10.3 0.00021 20.8 7.1 1.2 1 0 0 1 1 1 1 Yip1 domain Phos_pyr_kin PF08543.7 CDF90953.1 - 3.5e-06 26.4 0.0 4.3e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.19 CDF90953.1 - 7.3e-06 25.3 0.0 0.00025 20.2 0.0 2.1 2 0 0 2 2 2 2 pfkB family carbohydrate kinase HSP70 PF00012.15 CDF90954.1 - 1.3e-265 882.0 10.9 1.5e-265 881.8 7.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.8 CDF90954.1 - 1.3e-14 53.5 2.5 1.1e-12 47.1 0.3 2.3 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.11 CDF90954.1 - 0.001 18.7 0.1 0.0035 16.9 0.0 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.1 CDF90954.1 - 0.0013 18.5 6.1 0.67 9.8 1.1 4.2 3 1 0 3 3 3 2 Cell division protein FtsA Hydantoinase_A PF01968.13 CDF90954.1 - 0.014 14.5 2.7 0.23 10.5 0.1 3.2 2 1 0 3 3 3 0 Hydantoinase/oxoprolinase DUF2797 PF10977.3 CDF90954.1 - 0.039 13.5 1.5 0.085 12.4 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) Gp-FAR-1 PF05823.7 CDF90954.1 - 0.045 13.6 3.8 0.098 12.6 2.6 1.5 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Mod_r PF07200.8 CDF90954.1 - 1.3 8.9 9.6 2.5 7.9 6.6 1.5 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein CDT1 PF08839.6 CDF90955.1 - 0.00015 21.7 2.3 0.00025 21.0 0.9 1.9 2 0 0 2 2 2 1 DNA replication factor CDT1 like Hydrolase PF00702.21 CDF90956.1 - 1.8e-22 80.8 0.0 7.4e-22 78.8 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 CDF90956.1 - 1.4e-19 70.9 0.0 2.9e-19 70.0 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.15 CDF90956.1 - 4.3e-16 58.6 0.0 1.2e-15 57.1 0.0 1.7 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_like2 PF13246.1 CDF90956.1 - 5.3e-05 23.0 0.0 0.00013 21.8 0.0 1.6 1 0 0 1 1 1 1 Putative hydrolase of sodium-potassium ATPase alpha subunit Hydrolase_3 PF08282.7 CDF90956.1 - 0.00062 19.4 0.3 0.0018 17.9 0.2 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.8 CDF90956.1 - 0.052 12.8 0.1 0.13 11.5 0.0 1.6 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase MCM PF00493.18 CDF90957.1 - 1e-128 428.8 0.1 1.4e-128 428.4 0.1 1.2 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 CDF90957.1 - 2.8e-21 76.2 0.0 1e-20 74.4 0.0 2.0 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 CDF90957.1 - 1.2e-07 31.1 0.1 2.2e-06 27.0 0.0 2.6 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.21 CDF90957.1 - 0.0058 16.1 0.0 0.015 14.8 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.6 CDF90957.1 - 0.0075 15.8 0.0 0.015 14.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 CDF90957.1 - 0.095 12.4 0.0 0.23 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Bul1_N PF04425.7 CDF90958.1 - 1.6e-97 326.8 1.9 7.7e-97 324.6 1.3 1.9 1 1 0 1 1 1 1 Bul1 N terminus Bul1_C PF04426.7 CDF90958.1 - 3.4e-39 134.6 10.0 1.6e-21 76.7 2.6 2.5 1 1 1 2 2 2 2 Bul1 C terminus Glyco_hydro_81 PF03639.8 CDF90959.1 - 4.7e-277 920.6 26.6 4.7e-277 920.6 18.4 3.1 2 1 0 3 3 3 1 Glycosyl hydrolase family 81 eIF-5a PF01287.15 CDF90960.1 - 6.5e-28 96.4 0.1 1e-27 95.8 0.1 1.3 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold KOW PF00467.24 CDF90960.1 - 0.00029 20.4 0.5 0.00052 19.6 0.4 1.4 1 0 0 1 1 1 1 KOW motif EFP_N PF08207.7 CDF90960.1 - 0.0055 16.5 0.0 0.0088 15.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain Anp1 PF03452.9 CDF90961.1 - 2.9e-116 387.3 0.0 4.1e-116 386.8 0.0 1.2 1 0 0 1 1 1 1 Anp1 UBA PF00627.26 CDF90962.1 - 1e-23 82.4 2.4 1.2e-13 50.4 0.1 2.7 2 0 0 2 2 2 2 UBA/TS-N domain ubiquitin PF00240.18 CDF90962.1 - 4e-16 58.1 0.8 8.5e-16 57.1 0.6 1.5 1 0 0 1 1 1 1 Ubiquitin family XPC-binding PF09280.6 CDF90962.1 - 1.3e-14 53.4 0.7 3.3e-14 52.0 0.5 1.7 1 0 0 1 1 1 1 XPC-binding domain Rad60-SLD PF11976.3 CDF90962.1 - 7.4e-08 31.9 0.2 1.6e-07 30.9 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.1 CDF90962.1 - 0.0026 17.6 0.0 0.0026 17.6 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like CUE PF02845.11 CDF90962.1 - 0.04 13.4 0.1 1.7 8.1 0.0 3.5 3 1 1 4 4 4 0 CUE domain DUF2407 PF10302.4 CDF90962.1 - 0.057 13.6 4.2 0.16 12.1 2.9 2.0 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain TFIIA PF03153.8 CDF90962.1 - 0.22 11.3 20.8 0.41 10.4 14.4 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Epimerase PF01370.16 CDF90963.1 - 1.1e-20 74.0 0.0 2.3e-20 73.0 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CDF90963.1 - 1.5e-12 46.8 0.0 2.1e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 CDF90963.1 - 7.2e-10 38.2 0.1 1.2e-08 34.2 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.1 CDF90963.1 - 2.9e-09 37.1 0.0 7e-09 35.9 0.0 1.7 1 1 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 CDF90963.1 - 1e-06 28.7 0.0 1.8e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.10 CDF90963.1 - 1.1e-06 27.7 0.0 6.4e-06 25.2 0.0 1.9 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.5 CDF90963.1 - 2.1e-05 24.2 0.0 3.4e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 KR domain NmrA PF05368.8 CDF90963.1 - 6.6e-05 22.2 0.1 0.0032 16.7 0.1 2.4 2 1 0 2 2 2 1 NmrA-like family F420_oxidored PF03807.12 CDF90963.1 - 0.015 15.7 0.0 0.035 14.5 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent RmlD_sub_bind PF04321.12 CDF90963.1 - 0.016 14.1 0.0 0.039 12.8 0.0 1.8 1 1 0 1 1 1 0 RmlD substrate binding domain adh_short_C2 PF13561.1 CDF90963.1 - 0.097 12.4 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase HAD_2 PF13419.1 CDF90964.1 - 3.5e-20 72.9 0.0 5e-20 72.4 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 CDF90964.1 - 0.0022 17.6 0.0 0.0038 16.9 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 CDF90964.1 - 0.12 12.7 0.0 0.19 12.0 0.0 1.5 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Cytochrom_C PF00034.16 CDF90965.1 - 6.2e-10 39.7 0.2 1e-09 39.0 0.1 1.4 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.1 CDF90965.1 - 1.4e-07 31.5 1.5 1.5e-06 28.2 1.0 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.1 CDF90965.1 - 0.025 14.0 2.1 0.091 12.2 0.2 2.4 2 1 1 3 3 3 0 Cytochrome c-550 domain Cytochrom_C1 PF02167.10 CDF90965.1 - 0.039 13.6 0.1 0.071 12.7 0.0 1.5 1 1 1 2 2 2 0 Cytochrome C1 family Glyco_hydro_16 PF00722.16 CDF90966.1 - 1.9e-42 144.6 7.1 1.9e-42 144.6 4.9 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Chitin_bind_1 PF00187.14 CDF90966.1 - 0.13 12.2 15.0 0.26 11.2 10.4 1.5 1 0 0 1 1 1 0 Chitin recognition protein NAD_kinase PF01513.16 CDF90967.1 - 2.6e-79 265.9 0.0 3.8e-79 265.4 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase GDA1_CD39 PF01150.12 CDF90968.1 - 2.8e-114 381.9 0.0 3.6e-114 381.6 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.11 CDF90968.1 - 0.011 14.9 0.0 0.019 14.1 0.0 1.3 1 0 0 1 1 1 0 Ppx/GppA phosphatase family DUF1547 PF07577.6 CDF90968.1 - 0.016 14.8 0.1 0.33 10.6 0.0 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1547) Isy1 PF06246.7 CDF90969.1 - 3.3e-44 151.1 11.0 2.1e-42 145.2 5.6 2.1 1 1 1 2 2 2 2 Isy1-like splicing family Unstab_antitox PF09720.5 CDF90969.1 - 0.18 11.5 6.2 0.15 11.7 0.3 3.0 3 0 0 3 3 3 0 Putative addiction module component YL1_C PF08265.6 CDF90971.1 - 6.3e-14 51.2 0.2 1.3e-13 50.2 0.1 1.5 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain DUF402 PF04167.8 CDF90971.1 - 0.088 12.6 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF402) Beta_elim_lyase PF01212.16 CDF90972.1 - 1.9e-74 250.4 0.0 2.3e-74 250.1 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase FAD_binding_2 PF00890.19 CDF90973.1 - 2.3e-75 254.0 0.0 2.6e-75 253.8 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.19 CDF90973.1 - 1.9e-09 36.9 0.1 8.1e-06 24.9 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 CDF90973.1 - 6.4e-09 35.9 0.3 0.00037 20.4 0.1 3.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CDF90973.1 - 1.7e-08 34.3 0.0 7.5e-08 32.2 0.0 2.2 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 CDF90973.1 - 6.7e-07 28.6 2.8 0.00019 20.6 0.2 2.7 3 0 0 3 3 3 2 Thi4 family Pyr_redox_3 PF13738.1 CDF90973.1 - 8.7e-07 29.2 0.0 1.7e-05 25.0 0.0 2.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 CDF90973.1 - 1.3e-06 27.7 0.2 0.00058 19.0 0.1 2.4 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.2 CDF90973.1 - 2.5e-06 26.8 0.1 5.9e-06 25.6 0.0 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.17 CDF90973.1 - 0.00031 19.7 2.1 0.01 14.7 0.1 2.7 3 0 0 3 3 3 1 Glucose inhibited division protein A HI0933_like PF03486.9 CDF90973.1 - 0.0012 17.3 8.0 0.016 13.7 0.0 3.9 4 2 0 4 4 4 1 HI0933-like protein Lycopene_cycl PF05834.7 CDF90973.1 - 0.0036 16.2 0.5 0.02 13.7 0.1 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox PF00070.22 CDF90973.1 - 0.0044 17.4 0.0 3.4 8.1 0.0 3.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 CDF90973.1 - 0.024 13.2 0.2 0.48 8.9 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase AlaDh_PNT_C PF01262.16 CDF90973.1 - 0.073 12.6 0.3 0.31 10.6 0.0 2.0 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Sedlin_N PF04628.8 CDF90974.1 - 1.2e-10 41.3 0.1 1.4e-10 41.1 0.1 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region DUF676 PF05057.9 CDF90975.1 - 5.8e-38 130.3 0.0 1.2e-37 129.3 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.8 CDF90975.1 - 3.4e-07 30.0 0.0 8.8e-07 28.7 0.0 1.6 2 0 0 2 2 2 1 PGAP1-like protein Abhydrolase_6 PF12697.2 CDF90975.1 - 0.00036 20.4 0.0 0.0015 18.4 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CDF90975.1 - 0.002 17.8 0.0 0.0098 15.6 0.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.20 CDF90975.1 - 0.078 12.5 0.0 0.28 10.8 0.0 1.9 2 0 0 2 2 2 0 Lipase (class 3) Metallophos PF00149.23 CDF90977.1 - 2.6e-39 134.6 0.4 3.7e-39 134.2 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase OHCU_decarbox PF09349.5 CDF90978.1 - 3.6e-32 111.8 0.4 4.3e-32 111.5 0.3 1.0 1 0 0 1 1 1 1 OHCU decarboxylase Spectrin PF00435.16 CDF90978.1 - 0.056 13.7 0.4 0.14 12.4 0.1 1.8 2 0 0 2 2 2 0 Spectrin repeat Rho_GDI PF02115.12 CDF90979.1 - 2e-65 219.9 1.9 2.3e-65 219.7 1.3 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor SoxY PF13501.1 CDF90979.1 - 0.065 13.2 0.1 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Sulfur oxidation protein SoxY Tox-PLDMTX PF15645.1 CDF90979.1 - 0.16 11.9 0.9 0.26 11.3 0.6 1.5 1 1 0 1 1 1 0 Dermonecrotoxin of the Papain-like fold R3H PF01424.17 CDF90980.1 - 7.7e-11 41.5 0.2 1.7e-10 40.4 0.1 1.6 1 0 0 1 1 1 1 R3H domain SUZ PF12752.2 CDF90980.1 - 0.0072 16.8 0.1 0.0072 16.8 0.1 3.6 2 1 1 3 3 3 1 SUZ domain Spore_YhcN_YlaJ PF09580.5 CDF90980.1 - 5.5 7.0 0.0 5.5 7.0 0.0 2.7 2 1 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Ufd2P_core PF10408.4 CDF90981.1 - 2.1e-183 611.0 7.7 2.6e-183 610.6 5.3 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.10 CDF90981.1 - 1.3e-28 98.7 0.9 1.3e-28 98.7 0.6 2.2 2 0 0 2 2 2 1 U-box domain Ribosomal_L29 PF00831.18 CDF90982.1 - 2e-17 62.6 2.6 2e-17 62.6 1.8 2.1 2 0 0 2 2 2 1 Ribosomal L29 protein Annexin PF00191.15 CDF90982.1 - 0.0051 16.6 1.2 0.0066 16.3 0.1 1.8 2 0 0 2 2 2 1 Annexin DUF4404 PF14357.1 CDF90982.1 - 0.028 14.8 2.8 0.072 13.5 0.9 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) DUF4600 PF15372.1 CDF90982.1 - 0.38 10.9 6.9 0.8 9.9 4.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4600) Malate_DH PF12434.3 CDF90982.1 - 2 8.1 9.6 4 7.2 0.1 3.4 3 0 0 3 3 3 0 Malate dehydrogenase enzyme DUF2408 PF10303.4 CDF90982.1 - 3.9 7.6 7.3 8.4 6.5 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) YlqD PF11068.3 CDF90982.1 - 9.7 6.2 12.1 18 5.3 2.0 2.0 1 1 1 2 2 2 0 YlqD protein Arf PF00025.16 CDF90983.1 - 2.4e-78 261.3 0.1 2.8e-78 261.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 CDF90983.1 - 1.1e-14 54.2 0.0 1.1e-14 54.1 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 CDF90983.1 - 1.1e-14 54.0 0.0 1.3e-14 53.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.15 CDF90983.1 - 1.6e-11 43.5 0.7 1.5e-08 33.7 0.0 2.2 2 0 0 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 CDF90983.1 - 2.7e-11 43.0 0.0 3.3e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 CDF90983.1 - 6.7e-11 42.7 0.0 9.1e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 CDF90983.1 - 4.3e-06 26.6 0.0 6.2e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 CDF90983.1 - 0.0042 16.5 0.0 0.02 14.3 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRP54 PF00448.17 CDF90983.1 - 0.0054 16.1 0.2 0.011 15.1 0.1 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_33 PF13671.1 CDF90983.1 - 0.0054 16.6 0.1 0.009 15.8 0.1 1.5 1 1 0 1 1 1 1 AAA domain NACHT PF05729.7 CDF90983.1 - 0.02 14.5 0.6 2.1 7.9 0.0 2.1 2 0 0 2 2 2 0 NACHT domain ABC_tran PF00005.22 CDF90983.1 - 0.021 15.0 0.1 0.046 14.0 0.1 1.6 1 1 0 1 1 1 0 ABC transporter 6PF2K PF01591.13 CDF90983.1 - 0.031 13.3 0.1 0.049 12.6 0.1 1.4 1 1 0 1 1 1 0 6-phosphofructo-2-kinase cobW PF02492.14 CDF90983.1 - 0.058 12.8 0.2 6.3 6.2 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DBD_Tnp_Mut PF03108.10 CDF90983.1 - 0.065 12.8 0.0 0.15 11.6 0.0 1.6 1 0 0 1 1 1 0 MuDR family transposase Zeta_toxin PF06414.7 CDF90983.1 - 0.14 11.2 0.1 0.33 10.0 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin AAA_22 PF13401.1 CDF90983.1 - 0.14 12.2 0.2 0.41 10.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain Prenyltransf PF01255.14 CDF90984.1 - 0.0017 17.5 0.0 0.0028 16.8 0.0 1.4 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Sugar_tr PF00083.19 CDF90985.1 - 5.6e-121 404.2 25.6 6.6e-121 404.0 17.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CDF90985.1 - 1.4e-15 56.9 25.2 1.4e-15 56.9 17.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Pex14_N PF04695.8 CDF90985.1 - 0.047 13.7 1.3 3 7.8 0.1 2.8 2 1 1 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2530 PF10745.4 CDF90985.1 - 0.11 12.4 1.6 0.39 10.7 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) Sec31 PF11549.3 CDF90986.1 - 1e-23 82.6 5.2 3.8e-23 80.8 3.6 2.1 1 0 0 1 1 1 1 Protein transport protein SEC31 WD40 PF00400.27 CDF90986.1 - 8.3e-19 66.7 7.4 8.2e-07 28.6 0.0 7.3 8 0 0 8 8 8 4 WD domain, G-beta repeat SRA1 PF07304.6 CDF90986.1 - 1.4e-09 37.8 0.0 1.4e-09 37.8 0.0 2.9 2 1 1 3 3 3 1 Steroid receptor RNA activator (SRA1) Prp18 PF02840.10 CDF90986.1 - 0.0065 16.2 2.2 0.0076 16.0 0.2 2.1 2 1 0 2 2 2 1 Prp18 domain CHCH PF06747.8 CDF90987.1 - 6.7e-05 22.6 4.2 0.00011 21.9 2.9 1.4 1 0 0 1 1 1 1 CHCH domain Scm3 PF10384.4 CDF90988.1 - 2.5e-22 78.0 0.9 5.7e-22 76.9 0.6 1.6 1 0 0 1 1 1 1 Centromere protein Scm3 Pro_isomerase PF00160.16 CDF90989.1 - 1.3e-45 155.3 0.1 2.2e-45 154.6 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.23 CDF90989.1 - 8.3e-07 28.3 1.4 1.8e-05 24.1 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 CDF90989.1 - 6.7e-06 25.6 1.3 0.048 13.3 0.1 2.6 1 1 2 3 3 3 3 TPR repeat TPR_2 PF07719.12 CDF90989.1 - 0.00017 21.2 0.8 0.17 11.8 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 CDF90989.1 - 0.13 12.2 0.1 7.8 6.5 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 CDF90989.1 - 0.71 9.7 3.7 1.1 9.2 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat RNA_pol_Rpb1_1 PF04997.7 CDF90990.1 - 1.1e-120 402.9 0.0 2.1e-120 402.0 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.12 CDF90990.1 - 3.6e-108 361.0 0.2 6.5e-108 360.1 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.15 CDF90990.1 - 1.2e-72 243.2 0.3 5e-72 241.2 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.9 CDF90990.1 - 4.1e-67 225.5 0.5 1e-66 224.2 0.4 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.13 CDF90990.1 - 1e-46 158.5 0.0 3.2e-46 156.9 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.7 CDF90990.1 - 1.8e-44 150.7 2.9 4.2e-44 149.5 2.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.12 CDF90990.1 - 8.1e-35 118.8 0.1 2.3e-34 117.3 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.8 CDF90990.1 - 1.4e-13 49.7 309.6 0.28 11.4 10.3 15.4 9 1 0 15 15 15 13 RNA polymerase Rpb1 C-terminal repeat DUF4123 PF13503.1 CDF90990.1 - 0.027 14.4 0.0 0.053 13.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4123) CDP-OH_P_transf PF01066.16 CDF90991.1 - 8.2e-17 61.3 2.7 8.2e-17 61.3 1.9 1.5 1 1 0 1 1 1 1 CDP-alcohol phosphatidyltransferase TctB PF07331.6 CDF90991.1 - 0.038 13.6 0.1 0.073 12.7 0.1 1.5 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family Cpn60_TCP1 PF00118.19 CDF90992.1 - 8.4e-135 450.1 11.0 9.6e-135 449.9 7.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DeoC PF01791.4 CDF90992.1 - 0.021 14.1 0.5 0.52 9.5 0.1 2.5 2 0 0 2 2 2 0 DeoC/LacD family aldolase D123 PF07065.9 CDF90993.1 - 3.3e-100 335.0 0.2 3.9e-100 334.7 0.1 1.1 1 0 0 1 1 1 1 D123 DUF4343 PF14243.1 CDF90993.1 - 0.0073 16.1 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4343) W2 PF02020.13 CDF90993.1 - 0.022 14.7 0.4 0.094 12.6 0.3 2.0 2 0 0 2 2 2 0 eIF4-gamma/eIF5/eIF2-epsilon ApbA_C PF08546.6 CDF90994.1 - 1.5e-24 86.3 0.0 2.3e-24 85.7 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 CDF90994.1 - 7.7e-18 64.3 0.0 1.4e-17 63.5 0.0 1.4 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ThiF PF00899.16 CDF90994.1 - 0.014 15.2 0.3 0.066 13.0 0.4 1.9 2 0 0 2 2 2 0 ThiF family Glyco_hydro_16 PF00722.16 CDF90995.1 - 2.3e-44 150.8 0.2 4.4e-44 149.9 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 DUF4224 PF13986.1 CDF90995.1 - 0.13 11.7 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4224) Chitin_bind_1 PF00187.14 CDF90995.1 - 0.86 9.6 12.4 1.7 8.7 8.6 1.4 1 0 0 1 1 1 0 Chitin recognition protein Ribonuclease_T2 PF00445.13 CDF90996.1 - 5.2e-42 143.6 0.1 8.3e-42 142.9 0.1 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family SBDS_C PF09377.5 CDF90996.1 - 0.015 15.0 0.0 0.025 14.2 0.0 1.3 1 0 0 1 1 1 0 SBDS protein C-terminal domain KTSC PF13619.1 CDF90996.1 - 0.02 14.5 0.2 0.043 13.4 0.1 1.6 1 0 0 1 1 1 0 KTSC domain Transp_cyt_pur PF02133.10 CDF90997.1 - 8.9e-68 228.8 28.9 1e-67 228.5 20.1 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Macoilin PF09726.4 CDF90998.1 - 0.007 14.7 3.3 0.0083 14.4 2.3 1.2 1 1 0 1 1 1 1 Transmembrane protein IncA PF04156.9 CDF90998.1 - 0.01 15.4 5.3 0.033 13.8 0.4 2.1 2 0 0 2 2 2 0 IncA protein MscS_porin PF12795.2 CDF90998.1 - 0.017 14.4 2.1 0.017 14.4 1.5 2.1 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain V_ATPase_I PF01496.14 CDF90998.1 - 0.044 11.6 0.5 0.047 11.5 0.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1319 PF07028.6 CDF90998.1 - 0.092 12.9 2.5 0.28 11.3 1.7 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1319) Tnp_P_element PF12017.3 CDF90998.1 - 0.096 11.9 0.4 0.16 11.1 0.3 1.3 1 0 0 1 1 1 0 Transposase protein DUF4631 PF15450.1 CDF90998.1 - 0.14 10.4 7.7 0.052 11.8 3.5 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4631) GAS PF13851.1 CDF90998.1 - 0.21 10.7 5.6 0.29 10.2 1.0 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF641 PF04859.7 CDF90998.1 - 0.25 11.0 5.6 0.34 10.6 2.8 2.1 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) DUF2968 PF11180.3 CDF90998.1 - 0.29 10.5 8.6 0.025 13.9 2.9 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) Rap1_C PF11626.3 CDF90998.1 - 0.36 10.7 2.3 0.32 10.9 0.2 1.9 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain CENP-F_leu_zip PF10473.4 CDF90998.1 - 0.47 10.2 5.3 0.063 13.1 0.6 1.6 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Atg14 PF10186.4 CDF90998.1 - 0.72 8.7 5.0 1 8.2 3.5 1.2 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Coat_F PF07875.7 CDF90998.1 - 1.2 9.3 6.1 2.5 8.2 0.1 2.3 2 0 0 2 2 2 0 Coat F domain Filament PF00038.16 CDF90998.1 - 1.7 8.0 9.9 0.14 11.6 1.7 2.0 1 1 0 2 2 2 0 Intermediate filament protein SlyX PF04102.7 CDF90998.1 - 2.7 8.4 14.8 2.9 8.3 1.8 2.9 2 1 1 3 3 3 0 SlyX DUF1640 PF07798.6 CDF90998.1 - 3.1 7.7 7.8 18 5.3 5.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) FlxA PF14282.1 CDF90998.1 - 6.3 6.8 9.5 7.3 6.5 2.5 2.3 2 1 0 2 2 2 0 FlxA-like protein Fib_alpha PF08702.5 CDF90998.1 - 7.7 6.6 6.9 42 4.2 4.8 2.3 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Y_phosphatase PF00102.22 CDF90999.1 - 1.5e-58 197.8 0.7 1.9e-57 194.3 0.5 2.3 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 CDF90999.1 - 0.0037 17.5 0.2 0.015 15.5 0.0 2.1 2 0 0 2 2 2 1 Tyrosine phosphatase family DSPc PF00782.15 CDF90999.1 - 0.012 15.2 0.1 0.06 12.9 0.0 2.3 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 CDF90999.1 - 0.064 13.3 0.0 2 8.4 0.0 2.7 2 0 0 2 2 2 0 Inositol hexakisphosphate TMEM61 PF15105.1 CDF90999.1 - 0.072 12.6 0.3 0.16 11.4 0.0 1.6 2 0 0 2 2 2 0 TMEM61 protein family Guanylin PF02058.10 CDF90999.1 - 0.077 13.0 0.3 0.23 11.5 0.1 1.8 1 1 0 1 1 1 0 Guanylin precursor IBN_N PF03810.14 CDF91000.1 - 7.9e-17 60.9 0.5 3e-15 55.8 0.5 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain NAPRTase PF04095.11 CDF91001.1 - 2.8e-66 223.2 0.0 3.7e-66 222.9 0.0 1.1 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family WD40 PF00400.27 CDF91002.1 - 0.0029 17.4 0.2 0.0029 17.4 0.1 5.7 7 0 0 7 7 7 2 WD domain, G-beta repeat RNA_pol_N PF01194.12 CDF91003.1 - 8.3e-30 102.6 0.5 9.3e-30 102.4 0.4 1.0 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.7 CDF91003.1 - 0.058 13.4 0.2 0.073 13.1 0.1 1.3 1 0 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) YhfH PF14149.1 CDF91003.1 - 0.068 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 YhfH-like protein Dynamin_N PF00350.18 CDF91004.1 - 2e-41 141.6 0.2 2e-41 141.6 0.2 2.2 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.18 CDF91004.1 - 0.0014 18.6 0.0 0.0085 16.0 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CDF91004.1 - 0.0016 18.8 0.1 0.0055 17.1 0.1 2.1 1 1 0 1 1 1 1 Miro-like protein AAA_16 PF13191.1 CDF91004.1 - 0.022 14.7 0.6 0.071 13.0 0.1 2.1 2 1 0 2 2 2 0 AAA ATPase domain AKAP7_RIRII_bdg PF10470.4 CDF91004.1 - 0.084 12.7 0.1 0.084 12.7 0.1 2.2 2 0 0 2 2 2 0 PKA-RI-RII subunit binding domain of A-kinase anchor protein NOA36 PF06524.7 CDF91004.1 - 7.3 5.7 6.5 14 4.8 4.5 1.4 1 0 0 1 1 1 0 NOA36 protein Linker_histone PF00538.14 CDF91005.1 - 2.4e-40 136.4 3.6 2.5e-20 72.3 0.2 2.5 2 0 0 2 2 2 2 linker histone H1 and H5 family CENP-T PF15511.1 CDF91005.1 - 0.0022 17.2 9.2 0.0033 16.7 6.4 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T TRF PF08558.5 CDF91006.1 - 1.3e-77 260.4 0.0 1.8e-77 259.8 0.0 1.1 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.26 CDF91006.1 - 7.8e-07 29.0 0.1 1.6e-06 28.0 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.1 CDF91006.1 - 0.0007 19.6 0.1 0.0019 18.2 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain WD40 PF00400.27 CDF91007.1 - 1.9e-39 132.1 20.1 1.8e-06 27.5 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat eIF2A PF08662.6 CDF91007.1 - 0.0068 16.1 0.3 0.24 11.0 0.0 2.7 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Med9 PF07544.8 CDF91007.1 - 0.11 12.2 0.1 0.26 11.0 0.1 1.6 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 YEATS PF03366.11 CDF91008.1 - 4.1e-23 80.9 0.3 9.8e-23 79.6 0.0 1.7 2 0 0 2 2 2 1 YEATS family DUF2629 PF10945.3 CDF91008.1 - 0.12 11.7 0.1 0.42 10.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2629) YEATS PF03366.11 CDF91009.1 - 5.3e-25 86.9 0.1 8.6e-25 86.2 0.1 1.4 1 0 0 1 1 1 1 YEATS family YqeY PF09424.5 CDF91011.1 - 1.5e-23 83.2 1.7 1.8e-23 83.0 1.2 1.1 1 0 0 1 1 1 1 Yqey-like protein Pox_A3L PF05288.6 CDF91011.1 - 0.05 13.3 0.8 0.2 11.4 0.0 2.2 2 1 0 2 2 2 0 Poxvirus A3L Protein GRAB PF10375.4 CDF91012.1 - 8.2e-07 28.4 1.2 2.3e-06 27.0 0.8 1.8 1 0 0 1 1 1 1 GRIP-related Arf-binding domain IncA PF04156.9 CDF91012.1 - 4.3e-06 26.4 22.6 4.3e-06 26.4 15.7 4.1 1 1 3 4 4 4 2 IncA protein Spc7 PF08317.6 CDF91012.1 - 0.00032 19.4 42.7 0.0012 17.5 10.7 3.8 1 1 4 5 5 5 2 Spc7 kinetochore protein Reo_sigmaC PF04582.7 CDF91012.1 - 0.00056 19.1 16.7 0.00099 18.3 4.4 3.2 1 1 2 3 3 3 2 Reovirus sigma C capsid protein CCDC155 PF14662.1 CDF91012.1 - 0.0021 17.6 20.3 0.0021 17.6 14.1 3.5 1 1 2 3 3 2 2 Coiled-coil region of CCDC155 TMF_DNA_bd PF12329.3 CDF91012.1 - 0.0045 16.7 12.1 0.0045 16.7 8.4 6.9 2 2 4 6 6 6 1 TATA element modulatory factor 1 DNA binding Filament PF00038.16 CDF91012.1 - 0.0057 16.1 54.0 0.19 11.1 9.6 4.3 1 1 2 3 3 3 2 Intermediate filament protein ATG16 PF08614.6 CDF91012.1 - 0.0096 15.7 13.9 0.0096 15.7 9.6 5.0 1 1 4 5 5 4 2 Autophagy protein 16 (ATG16) Imm42 PF15601.1 CDF91012.1 - 0.015 14.6 2.1 0.015 14.6 1.5 2.7 2 1 0 2 2 2 0 Immunity protein 42 GAS PF13851.1 CDF91012.1 - 0.027 13.6 57.2 0.024 13.8 12.4 3.9 1 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.4 CDF91012.1 - 0.12 12.2 66.3 0.017 14.9 13.2 5.2 1 1 4 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ERM PF00769.14 CDF91012.1 - 0.18 11.3 61.1 0.18 11.3 16.9 3.3 1 1 2 3 3 3 0 Ezrin/radixin/moesin family WEMBL PF05701.6 CDF91012.1 - 0.9 7.9 56.3 1.3 7.4 34.0 3.3 1 1 1 2 2 2 0 Weak chloroplast movement under blue light DUF869 PF05911.6 CDF91012.1 - 1 7.4 57.3 13 3.8 39.7 2.7 1 1 0 1 1 1 0 Plant protein of unknown function (DUF869) AAA_13 PF13166.1 CDF91012.1 - 1.2 7.4 51.9 0.34 9.3 15.7 2.1 1 1 1 2 2 2 0 AAA domain DivIC PF04977.10 CDF91012.1 - 2.7 7.5 41.3 0.21 11.0 3.7 6.7 1 1 4 6 6 6 0 Septum formation initiator DUF3450 PF11932.3 CDF91012.1 - 8.3 5.5 37.7 0.055 12.7 7.5 4.4 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) RFC1 PF08519.7 CDF91013.1 - 4.6e-58 195.3 0.2 9.2e-57 191.1 0.0 2.4 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain AAA PF00004.24 CDF91013.1 - 1.2e-12 48.1 0.0 7.4e-12 45.6 0.0 2.4 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) BRCT PF00533.21 CDF91013.1 - 2.2e-11 43.7 0.0 6.7e-11 42.1 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Rad17 PF03215.10 CDF91013.1 - 1.6e-08 33.6 0.1 9.7e-06 24.5 0.0 2.3 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_17 PF13207.1 CDF91013.1 - 5.6e-07 30.4 0.0 5.9e-06 27.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 CDF91013.1 - 1.6e-05 25.0 0.0 6.2e-05 23.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.7 CDF91013.1 - 4.8e-05 22.5 0.0 9.4e-05 21.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_18 PF13238.1 CDF91013.1 - 6.8e-05 23.1 0.1 0.0013 18.9 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 CDF91013.1 - 0.00022 21.0 0.1 0.0012 18.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CDF91013.1 - 0.00054 20.0 0.1 0.006 16.5 0.0 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.1 CDF91013.1 - 0.0016 18.3 0.0 0.03 14.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CDF91013.1 - 0.0039 16.8 0.0 0.011 15.4 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain RNA_helicase PF00910.17 CDF91013.1 - 0.0057 16.8 0.0 0.018 15.2 0.0 1.9 1 0 0 1 1 1 1 RNA helicase PTCB-BRCT PF12738.2 CDF91013.1 - 0.0058 16.4 0.1 0.02 14.7 0.1 2.0 1 0 0 1 1 1 1 twin BRCT domain AAA_5 PF07728.9 CDF91013.1 - 0.011 15.5 0.1 0.056 13.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.1 CDF91013.1 - 0.098 12.6 0.8 0.23 11.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain HSD3 PF15244.1 CDF91013.1 - 2 7.5 14.0 0.041 13.1 3.3 2.2 2 0 0 2 2 2 0 Hydroxy-steroid dehydrogenase DPPIV_N PF00930.16 CDF91014.1 - 1.6e-89 299.9 4.4 2.4e-89 299.3 3.1 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.16 CDF91014.1 - 3.9e-47 160.2 1.6 7.2e-47 159.3 0.8 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.2 CDF91014.1 - 3.2e-06 26.9 0.0 5.7e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CDF91014.1 - 0.00054 19.9 0.0 0.019 14.8 0.0 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 CDF91014.1 - 0.0025 17.2 0.1 0.16 11.4 0.1 2.3 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase PAF-AH_p_II PF03403.8 CDF91014.1 - 0.047 11.9 0.1 0.096 10.9 0.1 1.4 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II LIP PF03583.9 CDF91014.1 - 0.049 12.8 0.7 8.1 5.5 0.0 2.6 3 0 0 3 3 3 0 Secretory lipase Ribosomal_L18p PF00861.17 CDF91015.1 - 1.6e-44 150.8 1.8 8.2e-44 148.6 0.0 2.2 2 0 0 2 2 2 1 Ribosomal L18p/L5e family Ribosomal_L18_c PF14204.1 CDF91015.1 - 1.4e-32 112.0 6.8 1.4e-32 112.0 4.7 1.6 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Metal_resist PF13801.1 CDF91015.1 - 0.013 15.4 0.5 0.04 13.9 0.0 2.0 2 0 0 2 2 2 0 Heavy-metal resistance Thr_synth_N PF14821.1 CDF91015.1 - 0.016 15.2 0.7 0.48 10.4 0.2 2.7 2 1 0 2 2 2 0 Threonine synthase N terminus MtrA PF04208.9 CDF91015.1 - 0.036 13.5 0.0 0.059 12.8 0.0 1.3 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit A NAC PF01849.13 CDF91015.1 - 0.1 12.1 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 NAC domain CtaG_Cox11 PF04442.9 CDF91017.1 - 9.7e-59 197.5 0.1 1.5e-58 196.8 0.1 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 Zn_clus PF00172.13 CDF91018.1 - 2.8e-05 23.9 7.9 7e-05 22.6 5.5 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Acyl_transf_1 PF00698.16 CDF91019.1 - 7.5e-05 22.2 0.0 0.00051 19.4 0.0 2.0 1 1 0 1 1 1 1 Acyl transferase domain Mito_carr PF00153.22 CDF91020.1 - 6.7e-66 218.0 0.6 3.5e-25 87.5 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF2407_C PF13373.1 CDF91021.1 - 4.7e-41 139.9 0.4 7.2e-41 139.3 0.3 1.3 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.4 CDF91021.1 - 1.8e-20 72.9 0.1 2.6e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain RNA_pol_Rpb8 PF03870.10 CDF91022.1 - 7.1e-44 149.3 0.0 8e-44 149.1 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 NifU_N PF01592.11 CDF91023.1 - 4.7e-52 175.2 0.1 5.7e-52 174.9 0.0 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain HTH_45 PF14947.1 CDF91024.1 - 0.033 13.9 0.9 2.8 7.8 0.1 2.5 2 0 0 2 2 2 0 Winged helix-turn-helix TPR_1 PF00515.23 CDF91024.1 - 0.39 10.3 1.4 0.91 9.2 0.9 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF1691 PF07950.6 CDF91025.1 - 9.4e-32 109.2 2.0 3.4e-15 55.9 0.3 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) Sdh_cyt PF01127.17 CDF91025.1 - 8.7e-07 28.8 4.8 1.2e-05 25.0 0.7 2.3 2 0 0 2 2 2 2 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF1469 PF07332.6 CDF91025.1 - 0.16 11.6 0.3 0.38 10.5 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) PHD PF00628.24 CDF91026.1 - 3.9e-13 48.8 5.9 1.2e-12 47.2 4.1 1.9 1 0 0 1 1 1 1 PHD-finger zf-RING_2 PF13639.1 CDF91026.1 - 0.22 11.3 5.0 1 9.2 3.5 2.2 1 0 0 1 1 1 0 Ring finger domain Pkinase PF00069.20 CDF91027.1 - 6.5e-68 228.6 0.0 1e-67 228.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF91027.1 - 1e-37 129.6 0.0 1.9e-37 128.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF91027.1 - 2e-09 36.8 0.0 3.5e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 CDF91027.1 - 0.00052 19.1 0.0 0.00076 18.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CDF91027.1 - 0.027 14.2 0.0 0.068 12.8 0.0 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 CDF91027.1 - 0.033 13.0 0.0 0.052 12.3 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 GrpE PF01025.14 CDF91028.1 - 1.1e-48 164.9 5.8 1.3e-48 164.6 4.0 1.1 1 0 0 1 1 1 1 GrpE Lip_prot_lig_C PF10437.4 CDF91028.1 - 0.0055 16.3 0.7 2.5 7.8 0.1 2.5 3 0 0 3 3 3 2 Bacterial lipoate protein ligase C-terminus IncA PF04156.9 CDF91028.1 - 0.032 13.8 3.8 0.041 13.4 2.6 1.1 1 0 0 1 1 1 0 IncA protein TraF PF13728.1 CDF91028.1 - 0.059 12.8 2.5 0.083 12.3 1.7 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein APG6 PF04111.7 CDF91028.1 - 0.087 11.8 5.0 0.12 11.4 3.4 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 Y_phosphatase3 PF13350.1 CDF91028.1 - 0.093 12.9 0.7 0.15 12.3 0.3 1.4 1 1 0 1 1 1 0 Tyrosine phosphatase family Syntaxin_2 PF14523.1 CDF91028.1 - 0.14 12.1 2.9 0.27 11.2 2.0 1.5 1 1 0 1 1 1 0 Syntaxin-like protein TPD52 PF04201.10 CDF91028.1 - 0.2 11.3 8.4 0.29 10.8 4.7 1.7 1 1 1 2 2 2 0 Tumour protein D52 family RE_Alw26IDE PF09665.5 CDF91028.1 - 0.38 9.4 2.9 0.48 9.0 2.0 1.1 1 0 0 1 1 1 0 Type II restriction endonuclease (RE_Alw26IDE) OmpH PF03938.9 CDF91028.1 - 0.71 9.8 9.1 1 9.2 6.3 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) GAS PF13851.1 CDF91028.1 - 0.84 8.7 11.0 1.5 7.9 7.6 1.4 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding RIC3 PF15361.1 CDF91028.1 - 0.94 9.7 3.2 1.9 8.7 2.2 1.5 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Bap31 PF05529.7 CDF91028.1 - 7.4 5.9 11.4 1.6 8.1 5.4 1.7 1 1 1 2 2 2 0 B-cell receptor-associated protein 31-like Pkinase PF00069.20 CDF91029.1 - 1.7e-66 224.0 0.0 3e-66 223.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF91029.1 - 1.5e-39 135.6 0.0 2.3e-39 135.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF91029.1 - 3.7e-08 32.6 0.0 6e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CDF91029.1 - 0.0037 17.0 0.1 0.01 15.5 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.9 CDF91029.1 - 0.0055 15.7 0.1 0.013 14.6 0.1 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.17 CDF91029.1 - 0.044 13.1 0.2 0.094 12.0 0.1 1.5 1 0 0 1 1 1 0 RIO1 family Ribosomal_L35Ae PF01247.13 CDF91030.1 - 6.1e-42 141.3 0.6 6.9e-42 141.1 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.13 CDF91030.1 - 0.00084 19.2 0.0 1.4 8.9 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain chaperone_DMP PF10448.4 CDF91032.1 - 1.2e-10 41.4 0.0 1.5e-10 41.1 0.0 1.3 1 1 0 1 1 1 1 20S proteasome chaperone DHFR_1 PF00186.14 CDF91033.1 - 1.7e-27 96.0 0.0 2.5e-27 95.4 0.0 1.2 1 0 0 1 1 1 1 Dihydrofolate reductase RibD_C PF01872.12 CDF91033.1 - 0.11 12.1 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 RibD C-terminal domain Oxysterol_BP PF01237.13 CDF91034.1 - 4.4e-90 301.7 0.2 5.3e-90 301.4 0.1 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein DUF1090 PF06476.7 CDF91034.1 - 0.084 12.5 2.6 0.16 11.5 1.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) Nop53 PF07767.6 CDF91035.1 - 7.4e-84 281.9 47.7 8.6e-84 281.7 33.1 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) ABC_membrane_2 PF06472.10 CDF91037.1 - 6.5e-84 281.3 5.3 9.7e-84 280.8 3.6 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 CDF91037.1 - 1.8e-12 47.7 0.0 1.3e-11 44.9 0.0 2.4 2 1 0 2 2 2 1 ABC transporter SMC_N PF02463.14 CDF91037.1 - 0.0074 15.5 0.0 0.03 13.5 0.0 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain DUF1749 PF08538.5 CDF91038.1 - 8.5e-93 310.5 0.0 9.5e-93 310.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.2 CDF91038.1 - 1.9e-08 34.4 0.0 2.4e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CDF91038.1 - 6.9e-07 29.1 0.0 4.8e-06 26.3 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 CDF91038.1 - 0.00053 19.2 0.0 0.012 14.8 0.0 2.3 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.15 CDF91038.1 - 0.064 12.8 0.0 0.11 12.0 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold Acetyltransf_1 PF00583.19 CDF91039.1 - 0.0035 17.3 0.0 0.0063 16.5 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family ACPS PF01648.15 CDF91040.1 - 5.4e-13 48.7 0.0 1.5e-12 47.3 0.0 1.6 1 1 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Nop14 PF04147.7 CDF91041.1 - 0.41 8.5 40.0 0.53 8.1 27.7 1.2 1 0 0 1 1 1 0 Nop14-like family Utp14 PF04615.8 CDF91041.1 - 2.4 6.2 47.1 2.9 5.9 32.7 1.1 1 0 0 1 1 1 0 Utp14 protein Methyltransf_23 PF13489.1 CDF91042.1 - 4.6e-16 58.9 0.0 6.8e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDF91042.1 - 3.9e-15 56.1 0.0 4.6e-14 52.7 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDF91042.1 - 4e-08 33.6 0.0 1e-07 32.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDF91042.1 - 3e-07 30.7 0.0 6.2e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDF91042.1 - 1.1e-06 28.3 0.0 2.2e-06 27.3 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDF91042.1 - 6.1e-05 23.5 0.0 0.00014 22.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CDF91042.1 - 0.0032 16.6 0.0 0.0048 16.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF3419 PF11899.3 CDF91042.1 - 0.0069 15.1 0.0 0.011 14.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Methyltransf_26 PF13659.1 CDF91042.1 - 0.009 16.0 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.12 CDF91042.1 - 0.038 12.9 0.0 5.1 5.9 0.0 2.1 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family MTS PF05175.9 CDF91042.1 - 0.15 11.4 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain APG5 PF04106.7 CDF91043.1 - 1.5e-43 148.6 0.0 1.9e-43 148.2 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 SGT1 PF07093.6 CDF91044.1 - 2.8e-41 141.6 14.8 8.5e-38 130.0 0.1 2.0 2 0 0 2 2 2 2 SGT1 protein MSA-2c PF12238.3 CDF91044.1 - 0.089 12.4 4.2 0.22 11.1 2.9 1.6 1 0 0 1 1 1 0 Merozoite surface antigen 2c Pkinase PF00069.20 CDF91045.1 - 5.2e-67 225.7 0.1 1.3e-66 224.4 0.1 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF91045.1 - 1.8e-37 128.8 0.0 3.2e-37 127.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF91045.1 - 9.3e-10 37.9 0.0 7.2e-09 35.0 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.9 CDF91045.1 - 0.001 18.1 0.2 0.027 13.5 0.0 2.3 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Mur_ligase_M PF08245.7 CDF91046.1 - 2.1e-07 31.1 0.0 1.3e-05 25.3 0.0 3.0 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.16 CDF91046.1 - 0.00029 20.8 0.0 0.00062 19.7 0.0 1.6 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain ST7 PF04184.7 CDF91047.1 - 0.015 13.5 0.1 0.022 13.0 0.0 1.1 1 0 0 1 1 1 0 ST7 protein TruD PF01142.13 CDF91048.1 - 3.8e-63 213.4 0.0 1.6e-58 198.2 0.0 3.3 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) RecT PF03837.9 CDF91048.1 - 0.036 13.3 0.5 0.084 12.1 0.4 1.6 1 0 0 1 1 1 0 RecT family WD40 PF00400.27 CDF91049.1 - 7.8e-48 158.7 18.9 8.4e-10 38.1 1.5 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Nucleoporin_N PF08801.6 CDF91049.1 - 8.6e-05 21.4 1.5 0.56 8.8 0.0 4.2 1 1 3 4 4 4 2 Nup133 N terminal like PQQ_2 PF13360.1 CDF91049.1 - 0.0052 16.2 0.2 0.22 10.9 0.0 2.7 2 1 0 2 2 2 1 PQQ-like domain MOZ_SAS PF01853.13 CDF91050.1 - 1.1e-90 301.9 1.0 1.7e-90 301.3 0.7 1.3 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.3 CDF91050.1 - 1.8e-21 75.6 0.0 4.5e-21 74.3 0.0 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Peptidase_M54 PF07998.6 CDF91050.1 - 0.044 13.5 0.2 0.094 12.4 0.1 1.5 1 0 0 1 1 1 0 Peptidase family M54 Acetyltransf_1 PF00583.19 CDF91050.1 - 0.098 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family HTH_11 PF08279.7 CDF91050.1 - 0.22 11.1 2.6 0.28 10.8 0.2 2.3 2 0 0 2 2 2 0 HTH domain PTPA PF03095.10 CDF91051.1 - 9.5e-116 386.1 0.1 1.2e-115 385.8 0.1 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein DAGAT PF03982.8 CDF91052.1 - 2.6e-80 269.2 0.5 2.2e-71 240.0 0.0 2.0 2 0 0 2 2 2 2 Diacylglycerol acyltransferase Acyltransferase PF01553.16 CDF91052.1 - 0.04 13.3 0.0 0.081 12.3 0.0 1.5 1 0 0 1 1 1 0 Acyltransferase Pkinase PF00069.20 CDF91053.1 - 5.3e-76 255.2 0.0 7.8e-76 254.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF91053.1 - 2.5e-36 125.0 0.0 4e-36 124.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.21 CDF91053.1 - 7.4e-26 90.0 3.3 1.3e-15 57.1 0.1 3.5 2 1 1 3 3 3 2 FHA domain Kinase-like PF14531.1 CDF91053.1 - 5.1e-11 42.0 0.0 8.9e-11 41.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.9 CDF91053.1 - 6.6e-06 25.3 0.0 1.2e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.18 CDF91053.1 - 1.1e-05 25.2 0.0 0.0077 15.9 0.0 2.7 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.17 CDF91053.1 - 0.0063 15.8 0.0 0.011 15.0 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Asp PF00026.18 CDF91054.1 - 3e-106 355.2 0.0 3.6e-106 355.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.1 CDF91054.1 - 2.2e-11 43.9 0.0 3.9e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.1 CDF91054.1 - 0.00039 19.9 0.0 0.002 17.7 0.0 2.1 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.1 CDF91054.1 - 0.0039 17.6 0.0 0.43 11.1 0.0 2.9 2 1 0 2 2 2 1 Aspartyl protease Kinesin PF00225.18 CDF91055.1 - 1.5e-106 355.8 0.1 2.5e-106 355.1 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Not3 PF04065.10 CDF91055.1 - 0.13 11.4 7.8 0.051 12.8 0.7 2.3 2 0 0 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component TMF_DNA_bd PF12329.3 CDF91055.1 - 0.17 11.6 10.2 17 5.3 0.2 4.5 4 0 0 4 4 4 0 TATA element modulatory factor 1 DNA binding Med9 PF07544.8 CDF91055.1 - 1 9.1 5.6 9 6.1 0.2 3.2 3 1 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Methyltransf_15 PF09445.5 CDF91056.1 - 1.7e-56 190.2 0.0 2.4e-56 189.8 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase UPF0020 PF01170.13 CDF91056.1 - 8.7e-07 28.6 0.0 1.3e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_26 PF13659.1 CDF91056.1 - 1.5e-06 28.2 0.0 2.5e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDF91056.1 - 5e-06 26.1 0.0 6.9e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDF91056.1 - 5e-05 23.8 0.0 8.3e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDF91056.1 - 0.0013 19.0 0.0 0.0098 16.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.15 CDF91056.1 - 0.0023 17.0 0.0 0.0047 16.0 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.9 CDF91056.1 - 0.0057 16.0 0.0 0.0089 15.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.13 CDF91056.1 - 0.012 14.7 0.0 0.018 14.1 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.1 CDF91056.1 - 0.013 15.2 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain tRNA_U5-meth_tr PF05958.6 CDF91056.1 - 0.02 13.5 0.0 0.037 12.7 0.0 1.4 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Pet20 PF08692.5 CDF91058.1 - 5.3e-26 91.1 9.5 2.1e-15 56.8 0.1 3.0 2 1 1 3 3 3 2 Mitochondrial protein Pet20 BMP2K_C PF15282.1 CDF91058.1 - 0.53 10.4 4.3 0.2 11.8 1.2 1.5 2 0 0 2 2 2 0 BMP-2-inducible protein kinase C-terminus tRNA-synt_1 PF00133.17 CDF91059.1 - 1.4e-45 155.4 0.2 7.4e-39 133.2 0.2 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 CDF91059.1 - 3.9e-18 65.2 0.7 7.9e-10 37.9 0.0 4.5 5 0 0 5 5 5 3 tRNA synthetases class I (M) Anticodon_1 PF08264.8 CDF91059.1 - 5.5e-13 48.9 0.0 1.3e-12 47.7 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.14 CDF91059.1 - 6.7e-07 28.7 0.0 1.5e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain adh_short PF00106.20 CDF91060.1 - 4.6e-14 52.6 0.0 5.5e-13 49.1 0.0 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CDF91060.1 - 0.0012 18.6 0.0 0.0025 17.6 0.0 1.4 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CDF91060.1 - 0.0037 16.9 0.0 0.013 15.1 0.0 1.8 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.5 CDF91060.1 - 0.0051 15.9 0.1 1.1 8.3 0.0 2.1 2 0 0 2 2 2 2 Fungal family of unknown function (DUF1776) Epimerase PF01370.16 CDF91060.1 - 0.017 14.5 0.0 0.021 14.2 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF3661 PF12400.3 CDF91062.1 - 1.2e-42 145.0 3.3 1.7e-42 144.5 2.3 1.2 1 0 0 1 1 1 1 Vaculolar membrane protein TFIIA PF03153.8 CDF91063.1 - 0.49 10.2 3.7 0.57 10.0 2.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit HATPase_c_3 PF13589.1 CDF91064.1 - 7e-13 48.4 0.0 1.2e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 CDF91064.1 - 1.2e-09 37.8 0.1 2.8e-09 36.6 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.6 CDF91064.1 - 3.5e-05 23.4 0.0 0.00026 20.5 0.0 2.2 2 0 0 2 2 2 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.14 CDF91064.1 - 0.0026 17.2 0.0 0.059 12.8 0.0 2.8 2 1 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain Apc5 PF12862.2 CDF91065.1 - 2.3e-30 104.2 4.6 6.5e-29 99.6 2.1 2.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 5 TPR_12 PF13424.1 CDF91065.1 - 0.00085 19.2 0.2 0.46 10.4 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat Apc3 PF12895.2 CDF91065.1 - 0.0063 16.6 5.5 0.009 16.1 0.1 3.3 3 1 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_5 PF12688.2 CDF91065.1 - 0.034 14.1 0.1 0.61 10.1 0.0 2.7 3 0 0 3 3 3 0 Tetratrico peptide repeat TPR_8 PF13181.1 CDF91065.1 - 0.058 13.2 0.8 2.9 7.8 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 CDF91065.1 - 0.059 13.7 0.6 0.21 11.9 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Clp1 PF06807.9 CDF91066.1 - 5.7e-17 62.1 0.0 9.1e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 MobB PF03205.9 CDF91066.1 - 1.1e-06 28.4 0.0 1.6e-05 24.5 0.0 2.2 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B MMR_HSR1 PF01926.18 CDF91066.1 - 0.00011 22.1 0.0 0.00039 20.3 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.13 CDF91066.1 - 0.00056 19.4 0.0 0.0012 18.3 0.0 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family PduV-EutP PF10662.4 CDF91066.1 - 0.00072 19.0 0.0 0.0015 18.0 0.0 1.5 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.12 CDF91066.1 - 0.0022 17.5 0.0 0.0068 15.9 0.0 1.7 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_16 PF13191.1 CDF91066.1 - 0.065 13.2 0.0 0.12 12.3 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain DUF2183 PF09949.4 CDF91066.1 - 0.067 13.1 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2183) AAA_22 PF13401.1 CDF91066.1 - 0.14 12.2 0.0 0.43 10.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain Rhodanese PF00581.15 CDF91067.1 - 4.2e-15 56.0 0.0 4e-06 27.1 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain SET PF00856.23 CDF91068.1 - 7.9e-10 39.2 0.1 1.1e-08 35.5 0.0 2.1 2 0 0 2 2 2 1 SET domain YHS PF04945.8 CDF91068.1 - 0.027 14.3 0.3 0.09 12.6 0.2 1.9 1 0 0 1 1 1 0 YHS domain DNA_pol_B PF00136.16 CDF91070.1 - 7.1e-97 325.0 0.7 7.1e-97 325.0 0.5 1.6 2 0 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 CDF91070.1 - 2e-19 69.6 0.2 1.1e-09 37.5 0.2 2.5 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.1 CDF91070.1 - 1.9e-13 50.2 7.4 6.7e-13 48.4 5.1 2.1 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta Rubredoxin PF00301.15 CDF91070.1 - 0.056 13.3 1.8 15 5.5 0.0 2.6 2 0 0 2 2 2 0 Rubredoxin DZR PF12773.2 CDF91070.1 - 0.24 11.2 4.3 0.62 9.9 3.0 1.7 1 0 0 1 1 1 0 Double zinc ribbon DUF2962 PF11176.3 CDF91071.1 - 2.2e-48 163.7 9.5 2.6e-48 163.5 6.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2962) Prok-E2_D PF14460.1 CDF91071.1 - 0.036 13.5 0.3 1.3 8.4 0.0 2.1 2 0 0 2 2 2 0 Prokaryotic E2 family D DUF1767 PF08585.7 CDF91071.1 - 0.038 14.2 0.4 0.11 12.7 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1767) DUF676 PF05057.9 CDF91073.1 - 2.6e-59 200.1 0.0 4.2e-59 199.5 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) LCAT PF02450.10 CDF91073.1 - 0.001 18.1 0.1 0.0023 16.9 0.0 1.5 2 0 0 2 2 2 1 Lecithin:cholesterol acyltransferase Lipase_3 PF01764.20 CDF91073.1 - 0.0045 16.5 0.0 0.012 15.2 0.0 1.7 1 1 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 CDF91073.1 - 0.0047 16.6 0.0 0.0096 15.6 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.8 CDF91073.1 - 0.057 13.0 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein RINT1_TIP1 PF04437.8 CDF91074.1 - 5.3e-91 305.6 18.2 9.6e-91 304.7 12.6 1.4 1 0 0 1 1 1 1 RINT-1 / TIP-1 family PrkA PF06798.7 CDF91074.1 - 0.0011 18.3 0.2 0.0035 16.6 0.1 1.9 1 0 0 1 1 1 1 PrkA serine protein kinase C-terminal domain Seryl_tRNA_N PF02403.17 CDF91074.1 - 0.59 10.1 8.0 0.33 10.9 1.9 2.8 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain CENP-F_N PF10481.4 CDF91075.1 - 0.027 13.8 0.3 0.033 13.5 0.2 1.2 1 0 0 1 1 1 0 Cenp-F N-terminal domain Med9 PF07544.8 CDF91075.1 - 0.065 12.9 0.5 0.45 10.2 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 IncA PF04156.9 CDF91075.1 - 0.067 12.7 1.1 0.078 12.5 0.7 1.1 1 0 0 1 1 1 0 IncA protein ISG65-75 PF11727.3 CDF91075.1 - 0.086 11.8 0.3 0.1 11.6 0.2 1.2 1 0 0 1 1 1 0 Invariant surface glycoprotein LXG PF04740.7 CDF91075.1 - 0.16 11.7 1.8 0.5 10.1 1.3 1.7 1 1 0 1 1 1 0 LXG domain of WXG superfamily bZIP_1 PF00170.16 CDF91075.1 - 0.17 11.8 1.0 1.5 8.8 0.1 2.2 2 0 0 2 2 2 0 bZIP transcription factor EMP24_GP25L PF01105.19 CDF91076.1 - 2.8e-07 30.4 0.1 3.9e-07 29.9 0.1 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD RNase_PH PF01138.16 CDF91077.1 - 7.5e-13 48.9 0.2 1e-12 48.5 0.1 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 CDF91077.1 - 0.02 14.8 0.0 0.037 13.9 0.0 1.5 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 SpoU_methylase PF00588.14 CDF91078.1 - 2.9e-24 85.5 0.0 6.1e-24 84.5 0.0 1.6 1 0 0 1 1 1 1 SpoU rRNA Methylase family PX PF00787.19 CDF91079.1 - 4.6e-24 84.3 0.1 2.2e-23 82.1 0.0 2.2 2 0 0 2 2 2 1 PX domain Vps5 PF09325.5 CDF91079.1 - 1.5e-08 34.2 13.5 1.3e-05 24.5 2.6 2.5 2 0 0 2 2 2 2 Vps5 C terminal like Syntaxin-6_N PF09177.6 CDF91079.1 - 0.0055 17.0 5.1 0.047 14.1 0.3 3.6 2 1 1 3 3 3 1 Syntaxin 6, N-terminal CCDC-167 PF15188.1 CDF91079.1 - 0.014 15.3 1.7 0.014 15.3 1.2 3.1 3 1 0 3 3 3 0 Coiled-coil domain-containing protein 167 DUF1395 PF07160.7 CDF91079.1 - 0.018 14.5 0.4 0.018 14.5 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1395) T2SF PF00482.18 CDF91079.1 - 0.093 12.6 0.6 9.6 6.1 0.1 2.6 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F DUF342 PF03961.8 CDF91079.1 - 0.8 8.0 16.8 0.012 14.0 1.4 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF342) DnaI_N PF07319.6 CDF91079.1 - 0.95 9.7 7.5 0.62 10.3 1.4 2.8 2 0 0 2 2 2 0 Primosomal protein DnaI N-terminus DUF106 PF01956.11 CDF91079.1 - 2.1 7.8 6.9 0.17 11.3 1.0 1.9 2 0 0 2 2 2 0 Integral membrane protein DUF106 adh_short PF00106.20 CDF91080.1 - 5.3e-27 94.7 0.0 9.4e-27 93.9 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CDF91080.1 - 4.3e-08 33.0 0.0 4e-07 29.8 0.0 2.2 1 1 0 1 1 1 1 KR domain DUF1762 PF08574.5 CDF91081.1 - 1.1e-19 70.6 13.6 1.1e-19 70.6 9.4 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1762) Ribosomal_L6 PF00347.18 CDF91082.1 - 1.4e-26 92.7 10.8 5.4e-13 49.2 2.6 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 PC4 PF02229.11 CDF91082.1 - 0.0021 17.2 0.4 0.0054 15.9 0.0 1.8 2 0 0 2 2 2 1 Transcriptional Coactivator p15 (PC4) UAF_Rrn10 PF05234.6 CDF91082.1 - 0.058 13.4 0.2 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 UAF complex subunit Rrn10 LRR_6 PF13516.1 CDF91082.1 - 0.15 12.2 0.0 0.71 10.1 0.0 2.1 1 0 0 1 1 1 0 Leucine Rich repeat Phage_T7_tail PF03906.9 CDF91082.1 - 0.36 10.4 1.9 2.1 7.9 0.1 2.4 1 1 1 2 2 2 0 Phage T7 tail fibre protein AdoMet_MTase PF07757.8 CDF91083.1 - 3.6e-41 139.7 0.1 6.4e-41 138.9 0.1 1.3 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_31 PF13847.1 CDF91083.1 - 0.004 16.7 0.1 0.0079 15.8 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 CDF91083.1 - 0.098 12.0 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_18 PF12847.2 CDF91083.1 - 0.11 13.1 0.0 0.47 11.0 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_32 PF13679.1 CDF91083.1 - 0.12 12.0 0.1 2.4 7.8 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Imm9 PF15561.1 CDF91083.1 - 0.12 11.9 0.5 12 5.4 0.0 2.3 2 0 0 2 2 2 0 Immunity protein 9 Pkinase PF00069.20 CDF91084.1 - 4.1e-76 255.5 0.0 4.7e-76 255.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF91084.1 - 6.7e-38 130.2 0.0 9.2e-38 129.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF91084.1 - 0.00056 18.9 0.0 0.00077 18.5 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 CDF91084.1 - 0.04 13.6 0.0 0.18 11.4 0.0 1.9 1 1 0 2 2 2 0 Phosphotransferase enzyme family DUF1573 PF07610.6 CDF91084.1 - 0.077 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1573) NAC PF01849.13 CDF91087.1 - 7.6e-17 60.5 0.2 1.5e-16 59.6 0.1 1.5 1 0 0 1 1 1 1 NAC domain Ribosomal_60s PF00428.14 CDF91087.1 - 0.0071 16.7 3.0 0.0071 16.7 2.1 2.1 2 1 0 2 2 2 1 60s Acidic ribosomal protein zf-C2H2_4 PF13894.1 CDF91088.1 - 3.9e-10 39.3 3.7 0.00061 19.9 0.0 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 CDF91088.1 - 6.1e-10 38.8 8.0 2.4e-05 24.4 1.1 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 CDF91088.1 - 0.00017 21.7 3.5 0.021 15.0 0.0 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_jaz PF12171.3 CDF91088.1 - 0.0027 17.8 0.6 1.4 9.1 0.0 2.3 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 CDF91088.1 - 0.0042 16.9 2.5 0.31 11.0 0.1 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger RIG-I_C-RD PF11648.3 CDF91088.1 - 0.035 13.9 1.2 0.076 12.8 0.2 1.9 1 1 1 2 2 2 0 C-terminal domain of RIG-I RRN7 PF11781.3 CDF91088.1 - 0.072 12.6 0.8 4.1 6.9 0.0 2.4 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 GAGA PF09237.6 CDF91088.1 - 0.079 12.5 0.6 0.17 11.5 0.1 1.7 2 0 0 2 2 2 0 GAGA factor zf-CCHC_5 PF14787.1 CDF91088.1 - 0.39 10.2 0.1 0.39 10.2 0.1 2.2 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger ACP_syn_III_C PF08541.5 CDF91089.1 - 0.15 12.1 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal tRNA-synt_1 PF00133.17 CDF91090.1 - 1e-160 535.6 0.0 1.3e-160 535.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 CDF91090.1 - 1.2e-23 83.4 0.0 8.2e-13 47.7 0.0 3.3 3 0 0 3 3 3 3 tRNA synthetases class I (M) Anticodon_1 PF08264.8 CDF91090.1 - 8.6e-20 71.0 4.8 4.5e-19 68.6 3.0 2.4 1 1 1 2 2 2 1 Anticodon-binding domain of tRNA zf-FPG_IleRS PF06827.9 CDF91090.1 - 0.00036 20.1 1.2 0.00084 18.9 0.8 1.7 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS DUF1031 PF06275.6 CDF91090.1 - 0.62 10.1 3.4 0.87 9.6 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1031) FLILHELTA PF10306.4 CDF91091.1 - 1.1e-22 79.8 0.0 1.9e-22 79.0 0.0 1.4 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA DUF2740 PF10872.3 CDF91091.1 - 0.028 14.0 0.9 0.055 13.1 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2740) Pkinase PF00069.20 CDF91092.1 - 1.8e-55 187.9 0.2 1.7e-53 181.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDF91092.1 - 4.2e-25 88.2 0.3 3.1e-24 85.4 0.1 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF91092.1 - 0.12 11.3 0.0 0.2 10.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like RRM_1 PF00076.17 CDF91093.1 - 3.3e-53 177.2 0.5 2.4e-15 55.9 0.0 5.5 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF91093.1 - 1.4e-45 153.1 0.7 5.8e-13 48.6 0.0 5.2 5 0 0 5 5 5 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF91093.1 - 8.5e-19 67.1 0.1 4.6e-07 29.5 0.0 4.7 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CENP-N PF05238.8 CDF91094.1 - 9e-96 321.3 0.0 1e-95 321.1 0.0 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like Vps16_C PF04840.7 CDF91095.1 - 9.6e-80 267.8 6.1 9.6e-80 267.8 4.3 1.5 2 0 0 2 2 2 1 Vps16, C-terminal region Vps16_N PF04841.8 CDF91095.1 - 1.2e-74 251.3 1.0 1.6e-74 250.8 0.7 1.2 1 0 0 1 1 1 1 Vps16, N-terminal region Skp1_POZ PF03931.10 CDF91096.1 - 1.2e-18 66.9 0.0 6.9e-18 64.5 0.0 1.8 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain BTB PF00651.26 CDF91096.1 - 0.0018 18.2 0.0 0.0037 17.2 0.0 1.5 1 1 0 1 1 1 1 BTB/POZ domain zf-RING_UBOX PF13445.1 CDF91097.1 - 7e-13 48.0 3.4 7e-13 48.0 2.4 2.4 2 0 0 2 2 2 1 RING-type zinc-finger CLTH PF10607.4 CDF91097.1 - 5.8e-08 32.5 1.4 5.8e-08 32.5 0.9 2.7 2 2 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain ApoLp-III PF07464.6 CDF91097.1 - 8.6e-05 22.6 3.8 8.6e-05 22.6 2.7 1.7 2 0 0 2 2 2 1 Apolipophorin-III precursor (apoLp-III) zf-RING_2 PF13639.1 CDF91097.1 - 0.014 15.2 2.7 0.046 13.5 1.9 2.0 1 0 0 1 1 1 0 Ring finger domain DUF148 PF02520.12 CDF91097.1 - 1.3 8.8 6.4 18 5.1 3.3 3.1 2 1 0 2 2 2 0 Domain of unknown function DUF148 Sgf11 PF08209.6 CDF91098.1 - 4e-16 58.0 3.0 6.1e-16 57.4 2.1 1.3 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) zf-C2HC_2 PF13913.1 CDF91098.1 - 0.032 13.9 0.2 0.044 13.4 0.1 1.2 1 0 0 1 1 1 0 zinc-finger of a C2HC-type Catalase PF00199.14 CDF91099.1 - 4.7e-171 568.6 1.1 6.1e-171 568.3 0.8 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.7 CDF91099.1 - 1.6e-11 43.9 0.4 5.6e-11 42.1 0.1 2.1 2 0 0 2 2 2 1 Catalase-related immune-responsive EF1G PF00647.14 CDF91100.1 - 2.3e-46 155.9 0.1 3.8e-46 155.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.20 CDF91100.1 - 3e-11 43.1 2.1 3e-11 43.1 0.0 2.1 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.15 CDF91100.1 - 8.5e-09 35.4 0.4 2.6e-08 33.9 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.1 CDF91100.1 - 7.5e-08 32.1 0.0 1.4e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.1 CDF91100.1 - 4.3e-05 23.9 0.0 8.5e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain BSP_II PF05432.6 CDF91101.1 - 0.72 9.0 15.7 1.3 8.2 10.9 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Nop14 PF04147.7 CDF91101.1 - 1.9 6.3 16.5 2.4 5.9 11.4 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.7 CDF91101.1 - 2.3 7.4 9.7 3.3 6.8 6.7 1.3 1 0 0 1 1 1 0 NOA36 protein Trypan_PARP PF05887.6 CDF91101.1 - 8.3 6.2 12.4 0.85 9.4 1.7 2.4 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Anp1 PF03452.9 CDF91102.1 - 2.4e-107 358.0 0.0 2.9e-107 357.8 0.0 1.1 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.21 CDF91102.1 - 0.0038 16.9 0.0 0.0077 15.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Alk_phosphatase PF00245.15 CDF91103.1 - 2.6e-127 425.0 0.3 3.1e-127 424.7 0.2 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.13 CDF91103.1 - 0.00071 19.0 0.0 0.0017 17.7 0.0 1.6 2 0 0 2 2 2 1 Metalloenzyme superfamily Arf PF00025.16 CDF91104.1 - 3.7e-48 163.0 0.1 4.8e-48 162.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.17 CDF91104.1 - 5.9e-14 51.7 0.0 7.1e-14 51.5 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.5 CDF91104.1 - 5.6e-13 48.5 0.0 7.1e-13 48.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Miro PF08477.8 CDF91104.1 - 8.2e-11 42.4 0.0 1.1e-10 41.9 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein G-alpha PF00503.15 CDF91104.1 - 8.4e-10 37.8 0.7 3.8e-06 25.8 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 CDF91104.1 - 1.6e-09 37.2 0.0 1.8e-09 37.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 CDF91104.1 - 2.5e-09 36.8 0.0 1.5e-08 34.2 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CDF91104.1 - 1.1e-06 28.5 0.0 1.9e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.1 CDF91104.1 - 0.001 19.2 0.0 0.0083 16.2 0.0 2.3 1 1 1 2 2 2 1 AAA domain Thymidylate_kin PF02223.12 CDF91104.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Thymidylate kinase AAA_14 PF13173.1 CDF91104.1 - 0.14 12.0 0.1 0.2 11.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain cwf21 PF08312.7 CDF91105.1 - 9.2e-13 47.8 8.9 9.2e-13 47.8 6.2 1.7 2 0 0 2 2 2 1 cwf21 domain SGT1 PF07093.6 CDF91105.1 - 0.02 13.3 9.7 0.024 13.0 6.8 1.0 1 0 0 1 1 1 0 SGT1 protein FCP1_C PF09309.5 CDF91105.1 - 0.034 13.4 10.4 0.039 13.2 7.2 1.1 1 0 0 1 1 1 0 FCP1, C-terminal Uds1 PF15456.1 CDF91105.1 - 0.12 12.4 10.8 0.19 11.7 7.5 1.4 1 1 0 1 1 1 0 Up-regulated During Septation APG6 PF04111.7 CDF91105.1 - 0.22 10.5 12.9 0.28 10.1 9.0 1.0 1 0 0 1 1 1 0 Autophagy protein Apg6 VSG_B PF13206.1 CDF91105.1 - 0.23 10.5 3.6 0.3 10.1 2.5 1.1 1 0 0 1 1 1 0 Trypanosomal VSG domain Cluap1 PF10234.4 CDF91105.1 - 0.29 10.3 8.2 0.34 10.0 5.7 1.1 1 0 0 1 1 1 0 Clusterin-associated protein-1 Sperm_Ag_HE2 PF05324.8 CDF91105.1 - 0.44 10.4 3.6 0.15 12.0 0.4 1.8 2 1 0 2 2 2 0 Sperm antigen HE2 Fib_alpha PF08702.5 CDF91105.1 - 0.88 9.6 11.2 0.13 12.3 2.5 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Med9 PF07544.8 CDF91105.1 - 1.5 8.5 8.7 2.1 8.1 6.0 1.4 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Packaging_FI PF14000.1 CDF91105.1 - 2.1 8.5 10.5 0.2 11.8 2.8 2.0 1 1 1 2 2 2 0 DNA packaging protein FI V_ATPase_I PF01496.14 CDF91105.1 - 6.2 4.5 7.3 6.7 4.4 5.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Glyco_transf_15 PF01793.11 CDF91107.1 - 4.1e-138 459.8 17.9 8.6e-138 458.7 12.4 1.5 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase TPR_11 PF13414.1 CDF91108.1 - 8e-19 67.0 11.4 2.5e-12 46.2 4.3 2.4 1 1 1 2 2 2 2 TPR repeat TPR_2 PF07719.12 CDF91108.1 - 6e-11 41.4 9.6 0.00011 21.8 2.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 CDF91108.1 - 4.8e-10 38.6 13.2 1.9e-05 24.0 3.7 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 CDF91108.1 - 3e-08 34.1 0.2 6.6e-05 23.4 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.1 CDF91108.1 - 3.2e-08 33.3 1.8 4.2e-06 26.6 0.2 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat Apc3 PF12895.2 CDF91108.1 - 7.7e-07 29.1 7.7 2.4e-06 27.6 4.2 2.2 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 CDF91108.1 - 4e-06 27.0 0.3 0.00022 21.5 0.0 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 CDF91108.1 - 5.1e-06 26.2 1.1 0.00016 21.5 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 CDF91108.1 - 2.2e-05 23.8 10.0 0.00055 19.5 1.6 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.1 CDF91108.1 - 0.00015 22.1 0.0 0.69 10.7 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 CDF91108.1 - 0.00015 21.5 8.4 0.45 10.4 0.0 3.7 3 1 1 4 4 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.1 CDF91108.1 - 0.016 14.9 3.2 2 8.4 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3808 PF10300.4 CDF91108.1 - 0.14 10.6 3.4 0.19 10.2 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) TPR_6 PF13174.1 CDF91108.1 - 4 8.0 9.4 11 6.7 0.0 3.5 4 0 0 4 4 3 0 Tetratricopeptide repeat INCENP_ARK-bind PF03941.10 CDF91109.1 - 2.4e-19 68.9 0.7 7e-19 67.4 0.5 1.8 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region Stimulus_sens_1 PF13756.1 CDF91109.1 - 0.53 10.6 5.7 1.1 9.6 1.4 3.0 2 1 1 3 3 3 0 Stimulus-sensing domain Sin_N PF04801.8 CDF91110.1 - 0.0014 17.5 0.4 0.0017 17.2 0.3 1.0 1 0 0 1 1 1 1 Sin-like protein conserved region IATP PF04568.7 CDF91110.1 - 0.031 14.2 0.2 0.063 13.3 0.2 1.5 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP Ada3 PF10198.4 CDF91110.1 - 0.04 13.6 0.1 0.057 13.1 0.0 1.2 1 0 0 1 1 1 0 Histone acetyltransferases subunit 3 zf-CCCH PF00642.19 CDF91111.1 - 2.6e-09 36.5 11.7 6e-05 22.6 2.1 2.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF4638 PF15472.1 CDF91111.1 - 0.057 13.0 3.0 0.091 12.3 2.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) zf-CCCH_2 PF14608.1 CDF91111.1 - 0.71 9.9 15.8 0.69 10.0 3.6 2.6 2 1 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type MIP-T3 PF10243.4 CDF91111.1 - 2.6 6.4 12.8 0.073 11.5 4.4 1.6 1 1 1 2 2 2 0 Microtubule-binding protein MIP-T3 DUF3043 PF11241.3 CDF91111.1 - 5.7 6.4 6.3 8.7 5.9 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) LRR_8 PF13855.1 CDF91112.1 - 0.016 14.9 1.2 5.2 6.8 0.0 3.6 2 1 1 3 3 3 0 Leucine rich repeat LRR_6 PF13516.1 CDF91112.1 - 0.026 14.5 4.0 5.3 7.4 0.0 5.2 6 0 0 6 6 6 0 Leucine Rich repeat LRR_7 PF13504.1 CDF91112.1 - 0.14 12.4 5.7 67 4.3 0.1 5.1 5 0 0 5 5 5 0 Leucine rich repeat LRR_1 PF00560.28 CDF91112.1 - 0.39 10.9 5.6 31 5.1 0.0 4.4 3 1 0 3 3 3 0 Leucine Rich Repeat Lge1 PF11488.3 CDF91113.1 - 2.2e-19 69.4 1.8 3.2e-19 68.9 1.2 1.2 1 0 0 1 1 1 1 Transcriptional regulatory protein LGE1 adh_short PF00106.20 CDF91114.1 - 3.6e-22 79.0 0.0 5.5e-22 78.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CDF91114.1 - 3.6e-10 40.0 0.1 5.2e-10 39.5 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CDF91114.1 - 9e-08 31.9 0.0 1.6e-07 31.1 0.0 1.4 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CDF91114.1 - 0.00031 20.7 0.0 0.00051 20.1 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding Polysacc_synt_2 PF02719.10 CDF91114.1 - 0.00066 18.6 0.3 0.00097 18.1 0.2 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Saccharop_dh PF03435.13 CDF91114.1 - 0.02 13.8 0.1 0.037 13.0 0.0 1.5 1 1 0 1 1 1 0 Saccharopine dehydrogenase DUF1071 PF06378.6 CDF91114.1 - 0.1 11.7 0.5 0.21 10.7 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1071) Pkinase PF00069.20 CDF91115.1 - 5.1e-73 245.4 0.0 5.8e-73 245.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF91115.1 - 1.2e-33 116.3 0.0 1.5e-33 116.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF91115.1 - 3.6e-06 26.1 0.0 5.9e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.18 CDF91115.1 - 0.01 15.5 0.3 0.048 13.3 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.9 CDF91115.1 - 0.015 14.3 0.1 0.04 12.9 0.1 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Gly_transf_sug PF04488.10 CDF91116.1 - 2.8e-20 72.5 0.0 4.8e-20 71.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.2 CDF91116.1 - 0.14 10.6 2.8 1.5 7.2 0.1 2.1 2 0 0 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain DUF2401 PF10287.4 CDF91117.1 - 5.2e-102 340.3 4.5 5.2e-102 340.3 3.1 2.8 3 1 0 3 3 3 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.4 CDF91117.1 - 6.1e-29 99.9 1.9 1.1e-28 99.1 0.1 2.4 2 0 0 2 2 2 1 Glycine-rich protein domain (DUF2403) RAMP4 PF06624.7 CDF91118.1 - 0.1 12.1 0.9 0.49 9.9 0.6 1.8 1 1 0 1 1 1 0 Ribosome associated membrane protein RAMP4 HD PF01966.17 CDF91121.1 - 7.3e-06 26.0 0.0 9.6e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 HD domain MFS_1 PF07690.11 CDF91122.1 - 3.7e-13 48.9 45.3 5.2e-12 45.1 30.5 3.1 2 1 0 2 2 2 1 Major Facilitator Superfamily Cupin_2 PF07883.6 CDF91123.1 - 6e-11 41.6 0.0 1.5e-10 40.4 0.0 1.6 1 1 1 2 2 2 1 Cupin domain Cupin_3 PF05899.7 CDF91123.1 - 2e-05 23.8 0.0 3.2e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) 3-HAO PF06052.7 CDF91123.1 - 3.4e-05 23.2 0.0 4.7e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_1 PF00190.17 CDF91123.1 - 5.9e-05 22.5 0.0 6.4e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 Cupin ARD PF03079.9 CDF91123.1 - 0.001 19.0 0.0 0.0013 18.7 0.0 1.1 1 0 0 1 1 1 1 ARD/ARD' family FdtA PF05523.6 CDF91123.1 - 0.0067 15.9 0.0 0.0088 15.5 0.0 1.1 1 0 0 1 1 1 1 WxcM-like, C-terminal cNMP_binding PF00027.24 CDF91123.1 - 0.046 13.5 0.0 0.088 12.6 0.0 1.5 1 1 0 1 1 1 0 Cyclic nucleotide-binding domain Cupin_6 PF12852.2 CDF91123.1 - 0.054 13.1 0.0 0.069 12.7 0.0 1.1 1 0 0 1 1 1 0 Cupin Cupin_4 PF08007.7 CDF91123.1 - 0.063 12.5 0.0 0.074 12.2 0.0 1.2 1 0 0 1 1 1 0 Cupin superfamily protein Cupin_7 PF12973.2 CDF91123.1 - 0.069 13.0 0.0 0.3 10.9 0.0 1.9 1 1 0 1 1 1 0 ChrR Cupin-like domain Fungal_trans_2 PF11951.3 CDF91125.1 - 1.6e-102 342.9 2.0 2.3e-102 342.4 1.4 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF91125.1 - 6.5e-12 45.1 7.6 6.5e-12 45.1 5.3 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TraG-D_C PF12696.2 CDF91125.1 - 0.023 14.5 0.5 0.023 14.5 0.3 1.9 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG Peptidase_M85 PF13678.1 CDF91125.1 - 0.032 13.6 0.2 1.7 7.9 0.1 2.3 2 0 0 2 2 2 0 NFkB-p65-degrading zinc protease TFIID-18kDa PF02269.11 CDF91126.1 - 1e-33 114.9 0.0 1.6e-33 114.3 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Histone PF00125.19 CDF91126.1 - 0.0017 18.4 0.0 0.007 16.4 0.0 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TAF PF02969.12 CDF91126.1 - 0.052 13.4 0.1 0.79 9.7 0.0 2.3 2 0 0 2 2 2 0 TATA box binding protein associated factor (TAF) VPS9 PF02204.13 CDF91127.1 - 3e-27 94.6 0.1 6.5e-27 93.6 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain CUE PF02845.11 CDF91127.1 - 1.3e-09 37.3 0.0 2.8e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 CUE domain Ribosomal_60s PF00428.14 CDF91127.1 - 0.21 12.0 3.4 0.5 10.7 2.4 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein Rad10 PF03834.9 CDF91128.1 - 9e-26 89.3 2.6 1.6e-25 88.5 1.8 1.4 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) Prefoldin PF02996.12 CDF91129.1 - 1.4e-25 89.2 3.4 1.9e-25 88.8 2.3 1.1 1 0 0 1 1 1 1 Prefoldin subunit CEP19 PF14933.1 CDF91129.1 - 0.017 15.4 1.1 5 7.3 0.0 2.3 2 0 0 2 2 2 0 CEP19-like protein ORC4_C PF14629.1 CDF91129.1 - 0.034 13.5 1.4 0.44 9.8 0.1 2.0 1 1 1 2 2 2 0 Origin recognition complex (ORC) subunit 4 C-terminus HN PF00423.14 CDF91129.1 - 0.034 12.4 6.7 0.04 12.1 4.6 1.0 1 0 0 1 1 1 0 Haemagglutinin-neuraminidase Glyco_hydro_8 PF01270.12 CDF91129.1 - 0.046 12.4 0.0 0.056 12.1 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 8 AAA_assoc_C PF09821.4 CDF91129.1 - 0.24 11.6 3.8 4.9 7.4 0.8 2.1 2 0 0 2 2 2 0 C-terminal AAA-associated domain DUF3276 PF11680.3 CDF91129.1 - 3.1 7.6 9.0 1 9.1 3.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3276) Utp14 PF04615.8 CDF91130.1 - 8.6e-191 635.8 69.8 8.6e-191 635.8 48.4 2.2 1 1 1 2 2 2 1 Utp14 protein Proteasome PF00227.21 CDF91131.1 - 4.9e-57 192.2 0.0 6e-57 192.0 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 CDF91131.1 - 3.5e-09 35.8 0.9 5.9e-09 35.0 0.1 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature RecA PF00154.16 CDF91131.1 - 0.1 11.6 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 recA bacterial DNA recombination protein RRM_5 PF13893.1 CDF91132.1 - 7.4e-07 28.9 0.0 1.2e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.19 CDF91132.1 - 1.8e-05 24.2 5.5 2.2e-05 24.0 1.0 2.2 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.17 CDF91132.1 - 0.00026 20.5 0.0 0.00038 20.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF91132.1 - 0.0095 15.8 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Rtf2 PF04641.7 CDF91133.1 - 1.6e-37 129.1 2.7 5.1e-37 127.4 1.9 1.7 1 1 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.3 CDF91133.1 - 0.023 14.1 0.1 0.19 11.2 0.0 2.2 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit COX14 PF14880.1 CDF91134.1 - 5.6e-22 77.1 0.0 7e-22 76.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c assembly RebB PF11747.3 CDF91134.1 - 0.0006 19.6 0.3 0.00083 19.1 0.2 1.3 1 0 0 1 1 1 1 Killing trait Ish1 PF10281.4 CDF91135.1 - 1.5e-36 124.0 18.8 2.8e-12 46.4 0.1 6.2 6 0 0 6 6 6 5 Putative stress-responsive nuclear envelope protein SAP PF02037.22 CDF91135.1 - 7.9e-05 22.0 0.0 0.015 14.8 0.0 3.1 2 0 0 2 2 2 1 SAP domain HeH PF12949.2 CDF91135.1 - 0.00014 21.3 0.1 0.1 12.1 0.0 4.0 4 0 0 4 4 4 1 HeH/LEM domain SAM_2 PF07647.12 CDF91135.1 - 0.025 14.4 7.7 10 6.0 0.1 5.5 5 2 1 6 6 6 0 SAM domain (Sterile alpha motif) Remorin_C PF03763.8 CDF91135.1 - 0.031 13.7 0.1 0.031 13.7 0.1 2.5 3 0 0 3 3 3 0 Remorin, C-terminal region DUF2325 PF10087.4 CDF91135.1 - 0.1 12.4 0.0 0.29 11.0 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2325) Ste50p-SAM PF09235.5 CDF91135.1 - 0.18 11.8 5.0 2.8 8.0 0.1 4.0 3 1 0 3 3 3 0 Ste50p, sterile alpha motif ArsR PF09824.4 CDF91136.1 - 0.054 12.8 0.0 0.14 11.4 0.0 1.6 1 0 0 1 1 1 0 ArsR transcriptional regulator Peptidase_M4 PF01447.13 CDF91136.1 - 0.13 12.3 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Thermolysin metallopeptidase, catalytic domain RPM2 PF08579.6 CDF91137.1 - 1.9e-44 150.6 0.3 9.1e-44 148.4 0.2 2.2 1 0 0 1 1 1 1 Mitochondrial ribonuclease P subunit (RPM2) PPR_2 PF13041.1 CDF91137.1 - 0.0017 18.2 0.1 5.3 7.0 0.0 4.4 4 0 0 4 4 4 1 PPR repeat family PPR_3 PF13812.1 CDF91137.1 - 0.013 15.7 0.1 22 5.6 0.0 4.6 4 0 0 4 4 4 0 Pentatricopeptide repeat domain FCP1_C PF09309.5 CDF91137.1 - 0.031 13.6 3.0 0.056 12.7 2.1 1.3 1 0 0 1 1 1 0 FCP1, C-terminal HMG_CoA_synt_C PF08540.5 CDF91138.1 - 1.7e-104 349.2 3.2 2.5e-104 348.7 2.2 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.12 CDF91138.1 - 2.7e-89 297.2 0.2 4.1e-89 296.6 0.1 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal F-box-like PF12937.2 CDF91139.1 - 3.1e-13 49.2 0.6 7.7e-13 47.9 0.4 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.28 CDF91139.1 - 5.9e-09 35.3 0.3 1.3e-08 34.2 0.2 1.5 1 0 0 1 1 1 1 F-box domain UIM PF02809.15 CDF91139.1 - 0.0023 17.3 3.8 0.0023 17.3 2.6 3.9 4 0 0 4 4 4 1 Ubiquitin interaction motif PRANC PF09372.5 CDF91139.1 - 0.018 14.9 0.0 0.059 13.3 0.0 1.9 1 0 0 1 1 1 0 PRANC domain PQQ PF01011.16 CDF91139.1 - 0.02 14.3 0.0 0.12 11.9 0.0 2.3 2 0 0 2 2 2 0 PQQ enzyme repeat WD40 PF00400.27 CDF91139.1 - 0.023 14.5 0.3 0.093 12.6 0.2 2.1 1 0 0 1 1 1 0 WD domain, G-beta repeat PET PF06297.9 CDF91139.1 - 0.074 12.7 0.1 0.3 10.7 0.1 2.0 1 0 0 1 1 1 0 PET Domain NAD_binding_1 PF00175.16 CDF91140.1 - 3.3e-25 88.7 0.0 5.3e-25 88.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 CDF91140.1 - 6.7e-25 87.1 0.0 1.1e-24 86.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 CDF91140.1 - 8.3e-06 25.7 0.0 3.9e-05 23.6 0.0 1.8 1 1 0 2 2 2 1 Ferric reductase NAD binding domain AA_permease_C PF13906.1 CDF91140.1 - 0.067 13.0 0.3 0.12 12.2 0.2 1.5 1 0 0 1 1 1 0 C-terminus of AA_permease ALO PF04030.9 CDF91141.1 - 8.8e-99 330.2 0.5 1.1e-98 329.9 0.4 1.1 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.18 CDF91141.1 - 2.1e-27 95.3 0.2 3.2e-27 94.6 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Tubulin PF00091.20 CDF91143.1 - 2.2e-71 240.0 0.0 3e-71 239.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 CDF91143.1 - 2e-49 166.8 0.1 3.1e-49 166.2 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Sugar_tr PF00083.19 CDF91144.1 - 8.1e-40 136.7 16.2 2.2e-38 132.0 11.2 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CDF91144.1 - 4.4e-22 78.2 20.0 3.7e-18 65.3 9.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1201 PF06716.6 CDF91144.1 - 0.048 13.4 2.4 0.14 11.9 1.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1201) SQS_PSY PF00494.14 CDF91145.1 - 9.8e-40 136.5 0.0 1.2e-39 136.2 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase Pept_tRNA_hydro PF01195.14 CDF91146.1 - 5.5e-44 149.8 0.0 6.3e-44 149.6 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase Gtr1_RagA PF04670.7 CDF91147.1 - 3.9e-94 314.1 0.8 6.2e-94 313.4 0.6 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.17 CDF91147.1 - 1.7e-09 37.3 0.9 3.7e-09 36.1 0.2 1.8 2 0 0 2 2 2 1 Ras family Miro PF08477.8 CDF91147.1 - 4.2e-08 33.6 0.1 1e-07 32.4 0.1 1.7 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDF91147.1 - 2e-07 30.4 1.0 5.6e-07 28.9 0.2 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 CDF91147.1 - 1e-06 28.6 0.0 3.1e-06 27.1 0.0 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.22 CDF91147.1 - 0.0074 16.5 0.1 0.015 15.5 0.1 1.7 1 1 0 1 1 1 1 ABC transporter AAA_29 PF13555.1 CDF91147.1 - 0.011 15.2 0.4 0.025 14.1 0.2 1.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain AIG1 PF04548.11 CDF91147.1 - 0.017 14.2 1.1 0.16 11.0 0.0 2.4 1 1 1 2 2 2 0 AIG1 family SopD PF11047.3 CDF91147.1 - 0.052 12.5 4.4 0.023 13.6 0.8 1.8 2 0 0 2 2 2 0 Salmonella outer protein D AAA_10 PF12846.2 CDF91147.1 - 0.11 11.8 0.2 0.23 10.8 0.1 1.4 1 1 0 1 1 1 0 AAA-like domain Guanylate_kin PF00625.16 CDF91147.1 - 0.24 10.8 3.3 2.1 7.7 1.3 2.5 2 1 0 2 2 2 0 Guanylate kinase tRNA-synt_2 PF00152.15 CDF91149.1 - 2.4e-72 243.5 0.0 3.3e-72 243.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.15 CDF91149.1 - 5.1e-06 25.8 0.2 0.00025 20.3 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 CDF91149.1 - 0.028 14.0 0.0 1.2 8.6 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) NAD_binding_6 PF08030.7 CDF91150.1 - 9.9e-20 71.0 0.0 1.5e-19 70.4 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 CDF91150.1 - 5.8e-14 52.2 19.0 8.6e-14 51.7 12.0 2.1 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 CDF91150.1 - 1.2e-11 44.4 0.0 2.2e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.7 CDF91151.1 - 1e-18 67.7 0.0 2.2e-18 66.6 0.0 1.6 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.14 CDF91151.1 - 3.1e-14 53.1 19.6 1.5e-13 50.9 13.0 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.7 CDF91151.1 - 1.9e-11 43.7 0.0 4.4e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain LIX1 PF14954.1 CDF91151.1 - 0.11 11.4 0.1 0.2 10.5 0.1 1.4 1 0 0 1 1 1 0 Limb expression 1 NAD_binding_6 PF08030.7 CDF91152.1 - 6.7e-18 65.0 0.1 9.7e-18 64.5 0.1 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.7 CDF91152.1 - 1.3e-15 57.1 0.0 4.9e-15 55.2 0.0 2.0 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.14 CDF91152.1 - 4e-15 55.9 20.1 4e-15 55.9 13.9 2.4 2 0 0 2 2 2 1 Ferric reductase like transmembrane component DUF165 PF02592.10 CDF91152.1 - 0.46 10.6 10.7 0.3 11.2 5.6 2.0 2 1 0 2 2 2 0 Uncharacterized ACR, YhhQ family COG1738 RNase_HII PF01351.13 CDF91153.1 - 3.5e-59 199.7 0.0 4.1e-59 199.5 0.0 1.0 1 0 0 1 1 1 1 Ribonuclease HII 2-oxoacid_dh PF00198.18 CDF91154.1 - 9.8e-74 247.4 0.6 1.5e-73 246.9 0.4 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.17 CDF91154.1 - 4.2e-16 58.3 0.1 8.2e-16 57.4 0.0 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.12 CDF91154.1 - 1.4e-13 50.1 0.1 3.9e-13 48.8 0.1 1.8 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.1 CDF91154.1 - 0.023 14.3 0.0 0.054 13.1 0.0 1.6 1 0 0 1 1 1 0 Biotin-lipoyl like DUF2481 PF10654.4 CDF91154.1 - 0.14 11.8 0.1 0.35 10.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2481) Tom7 PF08038.7 CDF91155.1 - 5.7e-20 70.4 0.2 7.3e-20 70.1 0.2 1.1 1 0 0 1 1 1 1 TOM7 family Mito_carr PF00153.22 CDF91156.1 - 1.9e-62 206.9 6.7 1.3e-23 82.4 0.3 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L13 PF00572.13 CDF91157.1 - 2.4e-25 89.0 0.0 4.7e-25 88.1 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L13 Fork_head PF00250.13 CDF91159.1 - 3.6e-36 123.0 0.3 3.6e-36 123.0 0.2 1.8 2 0 0 2 2 2 1 Fork head domain FHA PF00498.21 CDF91159.1 - 1.6e-10 40.9 0.0 3.4e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 FHA domain MOR2-PAG1_N PF14222.1 CDF91160.1 - 8.2e-191 635.4 8.7 2.5e-190 633.8 6.0 1.9 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.1 CDF91160.1 - 2.6e-93 312.5 1.1 2.6e-93 312.5 0.8 3.5 4 0 0 4 4 4 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.1 CDF91160.1 - 9.2e-17 59.9 12.9 1.3e-08 33.0 0.2 3.6 2 1 1 3 3 3 3 Cell morphogenesis central region MMS19_N PF14500.1 CDF91161.1 - 1.7e-92 309.3 9.6 3.5e-92 308.3 0.8 3.2 4 1 0 4 4 4 2 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.3 CDF91161.1 - 3.7e-87 292.7 18.1 3.7e-87 292.7 12.5 2.5 2 1 0 2 2 2 1 RNAPII transcription regulator C-terminal HEAT_2 PF13646.1 CDF91161.1 - 0.00035 20.7 0.1 1.1 9.6 0.0 4.4 3 1 1 4 4 4 1 HEAT repeats HEAT PF02985.17 CDF91161.1 - 0.00098 19.0 0.2 0.15 12.1 0.0 4.6 6 0 0 6 6 6 1 HEAT repeat Vac14_Fab1_bd PF12755.2 CDF91161.1 - 0.0091 16.3 0.1 0.32 11.4 0.0 3.3 1 1 1 2 2 2 1 Vacuolar 14 Fab1-binding region VHS PF00790.14 CDF91161.1 - 0.017 14.7 2.0 0.91 9.1 0.0 3.9 3 1 1 4 4 4 0 VHS domain HEAT_EZ PF13513.1 CDF91161.1 - 0.43 11.1 2.2 11 6.6 0.0 4.1 5 0 0 5 5 5 0 HEAT-like repeat DUF3140 PF11338.3 CDF91162.1 - 0.27 11.3 9.4 0.19 11.8 0.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3140) DUF342 PF03961.8 CDF91162.1 - 0.65 8.3 9.0 0.74 8.1 6.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) SNF2_N PF00176.18 CDF91163.1 - 1.3e-83 280.2 0.3 1.3e-83 280.2 0.2 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain Bromodomain PF00439.20 CDF91163.1 - 4e-21 74.7 0.4 1.7e-20 72.7 0.3 2.1 1 0 0 1 1 1 1 Bromodomain Helicase_C PF00271.26 CDF91163.1 - 7.2e-20 70.6 0.1 1.4e-17 63.2 0.0 3.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SnAC PF14619.1 CDF91163.1 - 7.3e-15 54.9 1.4 7.3e-15 54.9 1.0 4.9 5 0 0 5 5 5 1 Snf2-ATP coupling, chromatin remodelling complex ResIII PF04851.10 CDF91163.1 - 1.3e-06 28.4 0.0 1.3e-06 28.4 0.0 3.6 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit HSA PF07529.8 CDF91163.1 - 0.0029 17.3 3.4 0.0029 17.3 2.3 3.0 2 1 0 2 2 2 1 HSA Helicase_C_2 PF13307.1 CDF91163.1 - 0.022 14.6 0.4 0.094 12.6 0.0 2.3 2 0 0 2 2 2 0 Helicase C-terminal domain Ribosomal_L6 PF00347.18 CDF91164.1 - 5.1e-25 87.7 5.6 1.8e-12 47.5 0.2 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 UAF_Rrn10 PF05234.6 CDF91164.1 - 0.011 15.7 0.1 0.021 14.8 0.1 1.4 1 0 0 1 1 1 0 UAF complex subunit Rrn10 YbbR PF07949.7 CDF91164.1 - 0.027 14.5 0.1 2.5 8.2 0.0 2.6 1 1 1 2 2 2 0 YbbR-like protein PC4 PF02229.11 CDF91164.1 - 0.12 11.6 0.8 0.19 10.9 0.2 1.7 2 0 0 2 2 2 0 Transcriptional Coactivator p15 (PC4) Transket_pyr PF02779.19 CDF91165.1 - 3.2e-65 218.9 0.0 9.1e-65 217.4 0.0 1.8 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.15 CDF91165.1 - 8.4e-54 182.3 0.0 1.2e-53 181.7 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component adh_short PF00106.20 CDF91166.1 - 2.5e-24 86.0 0.3 3.5e-24 85.6 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 CDF91166.1 - 1.5e-09 37.9 0.0 1.9e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CDF91166.1 - 1.2e-06 28.3 0.2 1.9e-06 27.6 0.1 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 CDF91166.1 - 6.9e-06 26.1 0.0 1.4e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 CDF91166.1 - 8.8e-05 22.0 0.2 0.00086 18.8 0.2 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.5 CDF91166.1 - 0.00099 18.3 0.0 0.56 9.2 0.0 3.0 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) Saccharop_dh PF03435.13 CDF91166.1 - 0.0032 16.4 0.0 0.0044 16.0 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase Eno-Rase_NADH_b PF12242.3 CDF91166.1 - 0.0035 17.1 0.1 0.0069 16.1 0.1 1.5 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NmrA PF05368.8 CDF91166.1 - 0.027 13.7 0.0 0.045 13.0 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family SUN PF03856.8 CDF91167.1 - 7.8e-106 352.9 15.8 1.5e-105 351.9 11.0 1.5 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) FCP1_C PF09309.5 CDF91168.1 - 0.62 9.3 6.6 0.08 12.2 1.3 1.8 2 0 0 2 2 2 0 FCP1, C-terminal MFS_1 PF07690.11 CDF91169.1 - 4.6e-42 143.9 24.9 5.8e-38 130.4 9.1 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 CDF91169.1 - 5.4e-11 41.7 15.2 5.4e-11 41.7 10.5 3.2 2 2 1 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.8 CDF91169.1 - 3.3e-05 22.2 3.3 3.3e-05 22.2 2.3 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) CSTF2_hinge PF14327.1 CDF91169.1 - 0.046 13.8 0.1 0.09 12.8 0.1 1.4 1 0 0 1 1 1 0 Hinge domain of cleavage stimulation factor subunit 2 DUF4199 PF13858.1 CDF91169.1 - 0.19 11.6 10.7 0.74 9.7 1.6 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF4199) DnaJ PF00226.26 CDF91170.1 - 2.2e-24 84.9 1.0 3.6e-24 84.2 0.7 1.4 1 0 0 1 1 1 1 DnaJ domain CTDII PF01556.13 CDF91170.1 - 8.2e-20 70.5 0.3 5.6e-17 61.4 0.0 2.7 2 0 0 2 2 2 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.14 CDF91170.1 - 1.3e-14 53.9 17.6 2.1e-14 53.3 12.2 1.4 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.14 CDF91170.1 - 0.0087 15.7 9.5 0.15 11.7 0.9 2.3 1 1 1 2 2 2 2 Hydrogenase expression/synthesis hypA family Methyltransf_31 PF13847.1 CDF91171.1 - 2.9e-08 33.4 0.0 4.4e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CDF91171.1 - 1.6e-07 31.3 0.0 6.7e-07 29.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 CDF91171.1 - 2.1e-07 30.4 0.1 1.9e-06 27.4 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.2 CDF91171.1 - 1.3e-05 25.7 0.0 3.7e-05 24.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDF91171.1 - 0.00014 22.1 0.0 0.00025 21.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 CDF91171.1 - 0.0026 16.9 0.0 0.0038 16.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.4 CDF91171.1 - 0.013 14.9 0.1 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Gcd10p PF04189.8 CDF91172.1 - 3.3e-93 312.1 0.0 4.3e-93 311.7 0.0 1.1 1 0 0 1 1 1 1 Gcd10p family DUF2935 PF11155.3 CDF91172.1 - 0.0061 16.6 1.0 0.05 13.7 0.1 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF2935) SUKH-3 PF14433.1 CDF91172.1 - 0.051 13.3 0.0 0.098 12.4 0.0 1.4 1 0 0 1 1 1 0 SUKH-3 immunity protein Nol1_Nop2_Fmu PF01189.12 CDF91173.1 - 3.4e-106 354.7 0.0 7.8e-106 353.5 0.0 1.6 1 0 0 1 1 1 1 NOL1/NOP2/sun family Methyltransf_31 PF13847.1 CDF91173.1 - 0.0027 17.3 0.0 0.0059 16.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 CDF91173.1 - 0.0028 17.6 0.0 0.0058 16.6 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase NAM-associated PF14303.1 CDF91173.1 - 0.055 13.7 0.3 0.055 13.7 0.2 3.2 2 1 0 2 2 2 0 No apical meristem-associated C-terminal domain Peptidase_S64 PF08192.6 CDF91173.1 - 4.3 5.5 18.0 6.4 4.9 12.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 Actin PF00022.14 CDF91174.1 - 5.9e-54 182.9 0.0 3.8e-51 173.7 0.0 2.5 1 1 0 1 1 1 1 Actin Ras PF00071.17 CDF91175.1 - 1.9e-56 189.9 0.1 3.3e-56 189.1 0.1 1.4 1 1 0 1 1 1 1 Ras family Miro PF08477.8 CDF91175.1 - 3.1e-17 63.1 0.0 5.8e-17 62.2 0.0 1.4 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDF91175.1 - 3.3e-09 36.2 0.0 5.8e-09 35.4 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.22 CDF91175.1 - 0.00064 19.2 0.3 0.0025 17.2 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.5 CDF91175.1 - 0.00066 18.9 0.0 0.0011 18.2 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.18 CDF91175.1 - 0.00092 19.1 0.0 0.0021 17.9 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.7 CDF91175.1 - 0.00094 18.3 0.0 0.0012 18.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.15 CDF91175.1 - 0.015 13.9 0.0 0.016 13.9 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit PduV-EutP PF10662.4 CDF91175.1 - 0.032 13.7 0.0 0.69 9.3 0.0 2.6 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.22 CDF91175.1 - 0.041 14.1 0.6 0.081 13.2 0.4 1.8 1 1 0 1 1 1 0 ABC transporter Arch_ATPase PF01637.13 CDF91175.1 - 0.056 13.1 0.0 0.081 12.6 0.0 1.3 1 0 0 1 1 1 0 Archaeal ATPase SNARE_assoc PF09335.6 CDF91176.1 - 0.025 14.7 0.1 0.044 13.9 0.0 1.3 1 0 0 1 1 1 0 SNARE associated Golgi protein Syndecan PF01034.15 CDF91176.1 - 0.067 12.8 0.1 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 Syndecan domain Y_phosphatase2 PF03162.8 CDF91177.1 - 4.3e-50 169.2 0.0 4.9e-50 169.1 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 CDF91177.1 - 4.3e-07 30.3 0.0 5.6e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.22 CDF91177.1 - 0.024 13.9 0.0 0.031 13.6 0.0 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DSPc PF00782.15 CDF91177.1 - 0.033 13.7 0.0 0.045 13.3 0.0 1.1 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Aminotran_1_2 PF00155.16 CDF91178.1 - 1.6e-64 218.1 0.0 1.9e-64 217.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Porin_3 PF01459.17 CDF91180.1 - 1.6e-58 198.2 1.2 1.8e-58 198.0 0.8 1.0 1 0 0 1 1 1 1 Eukaryotic porin Vac7 PF12751.2 CDF91181.1 - 4.3e-25 88.3 3.0 9.5e-16 57.6 0.0 2.7 3 0 0 3 3 3 2 Vacuolar segregation subunit 7 DSPc PF00782.15 CDF91182.1 - 3.4e-33 114.0 0.0 4.6e-33 113.6 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 CDF91182.1 - 0.00013 22.0 0.0 0.00018 21.6 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.22 CDF91182.1 - 0.00044 19.6 0.0 0.00063 19.1 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.7 CDF91182.1 - 0.11 11.2 0.0 0.16 10.8 0.0 1.1 1 0 0 1 1 1 0 Initiator tRNA phosphoribosyl transferase COX4 PF02936.9 CDF91184.1 - 1.6e-40 138.1 0.2 1.7e-40 138.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DUF1289 PF06945.8 CDF91184.1 - 0.034 13.6 2.5 1.6 8.2 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1289) Methyltransf_16 PF10294.4 CDF91185.1 - 0.011 15.1 0.1 2.2 7.6 0.0 2.2 2 0 0 2 2 2 0 Putative methyltransferase COG5 PF10392.4 CDF91186.1 - 7.5e-40 135.9 1.6 7.5e-40 135.9 1.1 2.3 2 1 0 2 2 2 1 Golgi transport complex subunit 5 DUF342 PF03961.8 CDF91186.1 - 0.0063 14.9 1.4 0.0082 14.6 0.1 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF342) MutS_III PF05192.13 CDF91186.1 - 0.11 12.2 1.7 3.6 7.3 0.1 2.2 1 1 1 2 2 2 0 MutS domain III TAFH PF07531.9 CDF91186.1 - 0.13 11.9 1.6 0.89 9.2 0.1 3.0 2 1 2 4 4 4 0 NHR1 homology to TAF FERM_M PF00373.13 CDF91186.1 - 0.58 10.3 3.2 0.3 11.2 0.6 1.9 2 1 0 2 2 2 0 FERM central domain DUF2011 PF09428.5 CDF91187.1 - 2.6e-30 104.9 13.1 3.3e-30 104.6 9.1 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2011) Sec23_trunk PF04811.10 CDF91188.1 - 3.5e-70 236.1 0.1 2e-69 233.6 0.0 2.0 2 0 0 2 2 2 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.10 CDF91188.1 - 2.2e-23 81.6 0.1 2.2e-23 81.6 0.1 2.2 3 0 0 3 3 3 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.10 CDF91188.1 - 1.5e-16 59.6 6.0 2.6e-16 58.8 4.1 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.7 CDF91188.1 - 4.4e-14 52.7 0.4 1.8e-13 50.7 0.1 2.3 3 0 0 3 3 3 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.17 CDF91188.1 - 1.5e-09 37.4 0.0 3.4e-09 36.2 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat Metallopep PF12044.3 CDF91189.1 - 5.2e-166 552.3 0.0 6.2e-166 552.0 0.0 1.0 1 0 0 1 1 1 1 Putative peptidase family Jacalin PF01419.12 CDF91189.1 - 4.7e-06 26.5 0.0 4.5e-05 23.3 0.0 2.2 1 1 1 2 2 2 2 Jacalin-like lectin domain Reprolysin_3 PF13582.1 CDF91189.1 - 0.0027 18.2 0.3 0.0068 16.9 0.0 1.8 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 CDF91189.1 - 0.017 15.0 0.1 0.031 14.1 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_2 PF13574.1 CDF91189.1 - 0.11 12.5 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.1 CDF91189.1 - 0.15 11.6 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like 6PF2K PF01591.13 CDF91190.1 - 8.7e-80 266.9 0.0 1.3e-79 266.3 0.0 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.17 CDF91190.1 - 2.7e-27 95.7 0.1 8.1e-26 91.0 0.0 2.6 2 1 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.1 CDF91190.1 - 3.9e-09 36.5 0.0 3e-08 33.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.1 CDF91190.1 - 2.9e-07 31.3 0.0 9.5e-07 29.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 CDF91190.1 - 0.0013 18.6 0.0 0.02 14.8 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Zeta_toxin PF06414.7 CDF91190.1 - 0.0015 17.7 0.0 0.0028 16.7 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.1 CDF91190.1 - 0.0016 18.7 0.3 0.0072 16.6 0.0 2.3 2 1 1 3 3 3 1 AAA domain APS_kinase PF01583.15 CDF91190.1 - 0.0082 15.8 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase KTI12 PF08433.5 CDF91190.1 - 0.0087 15.2 0.0 0.019 14.1 0.0 1.5 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Ribosomal_S6 PF01250.12 CDF91190.1 - 0.034 13.9 0.1 0.092 12.5 0.1 1.7 1 0 0 1 1 1 0 Ribosomal protein S6 Mob1_phocein PF03637.12 CDF91191.1 - 1.5e-73 246.1 0.7 1.9e-73 245.8 0.5 1.1 1 0 0 1 1 1 1 Mob1/phocein family Glycos_transf_1 PF00534.15 CDF91192.1 - 7.2e-14 51.5 0.0 1.4e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 CDF91192.1 - 0.018 15.1 0.0 0.037 14.1 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 DUF3186 PF11382.3 CDF91192.1 - 0.058 12.5 0.0 0.11 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3186) PH PF00169.24 CDF91193.1 - 8.7e-17 61.2 1.4 1.1e-16 60.8 0.2 1.8 2 0 0 2 2 2 1 PH domain DUF4515 PF14988.1 CDF91193.1 - 0.036 13.7 0.9 0.25 10.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4515) Peptidase_M1 PF01433.15 CDF91194.1 - 1.5e-76 258.0 0.0 2e-76 257.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 Leuk-A4-hydro_C PF09127.6 CDF91194.1 - 2.2e-44 150.5 0.0 4e-44 149.6 0.0 1.4 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_MA_2 PF13485.1 CDF91194.1 - 4.6e-15 55.7 0.1 8.2e-15 54.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase MA superfamily Peptidase_M61 PF05299.7 CDF91194.1 - 0.33 10.9 2.4 2 8.4 1.6 2.2 1 1 0 1 1 1 0 M61 glycyl aminopeptidase PRA1 PF03208.14 CDF91195.1 - 4.8e-40 136.4 1.8 5.5e-40 136.2 1.2 1.0 1 0 0 1 1 1 1 PRA1 family protein SUR7 PF06687.7 CDF91195.1 - 0.0054 16.3 1.2 0.007 15.9 0.8 1.1 1 0 0 1 1 1 1 SUR7/PalI family Tic20 PF09685.5 CDF91195.1 - 1.9 8.4 8.9 0.26 11.2 0.4 2.1 1 1 1 2 2 2 0 Tic20-like protein DUF3094 PF11293.3 CDF91195.1 - 7.2 6.1 6.2 19 4.8 1.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) DUF2722 PF10846.3 CDF91196.1 - 6.6e-50 170.3 27.9 3.5e-49 167.9 19.3 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF2722) PAT1 PF09770.4 CDF91196.1 - 0.45 8.6 35.6 0.31 9.2 13.2 2.0 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 DUF4557 PF15101.1 CDF91196.1 - 6.4 6.5 13.9 1.5 8.6 1.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4557) SHQ1 PF04925.10 CDF91197.1 - 1.9e-69 232.9 1.4 2.7e-69 232.4 0.9 1.2 1 0 0 1 1 1 1 SHQ1 protein Diphthamide_syn PF01866.12 CDF91198.1 - 7.6e-114 380.0 0.1 9.4e-114 379.7 0.1 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein COG6 PF06419.6 CDF91199.1 - 1.4e-145 485.8 20.8 2e-145 485.3 14.4 1.2 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Rad51 PF08423.6 CDF91200.1 - 4.4e-136 451.7 0.0 5.7e-136 451.4 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 CDF91200.1 - 4.7e-14 52.2 0.0 7e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.1 CDF91200.1 - 2.1e-13 50.2 0.3 5.3e-13 48.9 0.2 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain RecA PF00154.16 CDF91200.1 - 2.5e-11 43.2 0.0 3.5e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein KaiC PF06745.8 CDF91200.1 - 1.7e-06 27.3 0.0 2.8e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 KaiC DnaB_C PF03796.10 CDF91200.1 - 0.03 13.1 0.0 0.072 11.9 0.0 1.6 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_22 PF13401.1 CDF91200.1 - 0.032 14.3 0.0 0.068 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain HHH PF00633.18 CDF91200.1 - 0.066 12.9 0.0 0.19 11.4 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Sec7 PF01369.15 CDF91201.1 - 2.1e-27 96.0 2.7 4.9e-27 94.8 1.9 1.6 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.1 CDF91201.1 - 0.013 15.6 0.4 0.068 13.3 0.1 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain Pax2_C PF12403.3 CDF91201.1 - 0.17 11.5 3.1 4.2 7.0 1.0 2.5 1 1 1 2 2 2 0 Paired-box protein 2 C terminal Proteasome PF00227.21 CDF91202.1 - 8.1e-42 142.6 0.0 1e-41 142.3 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Cmc1 PF08583.5 CDF91203.1 - 7e-17 60.9 8.0 1e-16 60.4 5.5 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like HMG_box_2 PF09011.5 CDF91203.1 - 0.0082 16.4 1.0 0.02 15.2 0.7 1.6 1 0 0 1 1 1 1 HMG-box domain NDUF_B7 PF05676.8 CDF91203.1 - 0.14 11.5 3.2 0.3 10.5 2.2 1.6 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DUF4606 PF15379.1 CDF91203.1 - 0.15 12.1 2.8 0.2 11.7 1.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4606) DUF104 PF01954.11 CDF91203.1 - 0.19 11.7 2.0 0.34 10.9 1.1 1.7 2 0 0 2 2 2 0 Protein of unknown function DUF104 CHCH PF06747.8 CDF91203.1 - 1.6 8.7 4.7 2.7 8.0 0.2 2.4 2 0 0 2 2 2 0 CHCH domain RICTOR_N PF14664.1 CDF91205.1 - 2.1e-106 355.6 15.9 5.5e-106 354.2 11.0 1.7 1 1 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.1 CDF91205.1 - 2.3e-74 249.2 0.8 2.3e-74 249.2 0.6 4.5 4 2 1 5 5 5 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.1 CDF91205.1 - 7.7e-30 102.6 0.9 3e-28 97.5 0.6 3.0 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, domain 5 RasGEF_N_2 PF14663.1 CDF91205.1 - 5.4e-29 100.4 0.1 2.6e-28 98.2 0.0 2.2 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain PEP-utilisers_N PF05524.8 CDF91205.1 - 0.033 13.9 0.7 8.9 6.1 0.1 2.5 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal RNA_pol_L_2 PF13656.1 CDF91205.1 - 0.053 12.9 1.2 0.2 11.1 0.1 2.5 3 0 0 3 3 2 0 RNA polymerase Rpb3/Rpb11 dimerisation domain FlxA PF14282.1 CDF91205.1 - 0.075 12.9 15.8 0.19 11.7 1.6 2.7 1 1 1 2 2 2 0 FlxA-like protein IncA PF04156.9 CDF91205.1 - 0.094 12.3 5.6 0.24 10.9 3.9 1.6 1 0 0 1 1 1 0 IncA protein DUF4407 PF14362.1 CDF91205.1 - 0.27 10.1 2.1 0.45 9.4 1.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Prefoldin_2 PF01920.15 CDF91205.1 - 0.32 10.7 10.7 1.7 8.4 7.4 2.2 1 1 0 1 1 1 0 Prefoldin subunit HR1 PF02185.11 CDF91205.1 - 0.36 10.5 8.8 0.88 9.3 5.6 2.1 1 1 1 2 2 2 0 Hr1 repeat DUF342 PF03961.8 CDF91205.1 - 0.72 8.2 4.8 1.4 7.2 3.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF342) SlyX PF04102.7 CDF91205.1 - 0.99 9.8 5.8 8.6 6.8 0.2 2.9 2 0 0 2 2 2 0 SlyX Uds1 PF15456.1 CDF91205.1 - 1.2 9.1 11.8 0.68 9.9 5.6 2.4 2 0 0 2 2 2 0 Up-regulated During Septation Prefoldin PF02996.12 CDF91205.1 - 1.3 8.6 7.8 31 4.2 5.5 2.7 1 1 0 1 1 1 0 Prefoldin subunit Spc24 PF08286.6 CDF91205.1 - 2 8.1 11.0 2.4 7.8 1.9 2.7 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Seryl_tRNA_N PF02403.17 CDF91205.1 - 5.8 6.9 10.8 0.78 9.7 0.8 3.0 3 0 0 3 3 2 0 Seryl-tRNA synthetase N-terminal domain DUF4140 PF13600.1 CDF91205.1 - 6.5 7.2 8.7 8.5 6.8 0.5 2.5 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) FliJ PF02050.11 CDF91205.1 - 6.9 6.7 13.1 1.3 9.0 6.1 2.0 2 0 0 2 2 1 0 Flagellar FliJ protein TMF_DNA_bd PF12329.3 CDF91205.1 - 8.6 6.2 12.7 2.6 7.9 1.3 2.9 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.10 CDF91205.1 - 9.1 5.8 10.3 6.5 6.3 1.1 2.7 2 0 0 2 2 2 0 Septum formation initiator Meth_synt_2 PF01717.13 CDF91207.1 - 2.6e-143 476.8 0.0 2.6e-138 460.4 0.0 2.4 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.7 CDF91207.1 - 1.7e-129 431.5 0.1 3e-116 388.0 0.1 3.1 3 0 0 3 3 3 3 Cobalamin-independent synthase, N-terminal domain SEP PF08059.8 CDF91208.1 - 5.4e-27 93.9 3.2 1.6e-26 92.4 0.2 2.4 2 0 0 2 2 2 1 SEP domain UBX PF00789.15 CDF91208.1 - 4e-18 65.2 0.0 7.4e-18 64.3 0.0 1.4 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.1 CDF91208.1 - 4.2e-07 29.4 2.2 7.3e-07 28.6 1.5 1.4 1 0 0 1 1 1 1 UBA-like domain PTH2 PF01981.11 CDF91209.1 - 1.3e-44 150.6 0.1 2.2e-44 149.8 0.1 1.4 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Minor_capsid_3 PF12691.2 CDF91209.1 - 0.055 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Minor capsid protein from bacteriophage Siah-Interact_N PF09032.6 CDF91209.1 - 0.075 13.1 0.2 0.14 12.2 0.1 1.4 1 0 0 1 1 1 0 Siah interacting protein, N terminal Phage_connect_1 PF05135.8 CDF91209.1 - 0.095 12.8 0.4 0.19 11.9 0.3 1.4 1 0 0 1 1 1 0 Phage gp6-like head-tail connector protein Chorismate_bind PF00425.13 CDF91210.1 - 2.4e-86 289.2 0.0 4.6e-85 285.0 0.0 2.0 2 0 0 2 2 2 1 chorismate binding enzyme Anth_synt_I_N PF04715.8 CDF91210.1 - 7.5e-30 103.7 0.1 2.7e-27 95.5 0.0 3.2 2 1 0 2 2 2 1 Anthranilate synthase component I, N terminal region DUF466 PF04328.8 CDF91210.1 - 0.0026 17.5 0.0 3.5 7.5 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF466) PP2C PF00481.16 CDF91211.1 - 2.2e-79 266.4 0.0 3e-79 266.0 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C TatD_DNase PF01026.16 CDF91212.1 - 1.6e-37 129.1 0.0 2.1e-37 128.6 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase Myb_DNA-bind_6 PF13921.1 CDF91213.1 - 2.5e-10 40.3 2.1 6.5e-10 38.9 0.2 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 CDF91213.1 - 6.8e-07 29.2 0.9 1.5e-05 24.9 0.1 2.5 2 0 0 2 2 2 1 Myb-like DNA-binding domain Ribosomal_60s PF00428.14 CDF91213.1 - 2.6 8.4 17.5 0.98 9.8 6.2 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein MOZ_SAS PF01853.13 CDF91214.1 - 1e-78 262.9 0.3 2.1e-78 261.8 0.2 1.6 1 0 0 1 1 1 1 MOZ/SAS family Myc_N PF01056.13 CDF91214.1 - 0.076 12.1 7.1 0.17 11.0 4.9 1.6 1 0 0 1 1 1 0 Myc amino-terminal region Mtf2_C PF14061.1 CDF91214.1 - 0.12 12.3 0.1 0.33 10.8 0.0 1.7 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 RRM_6 PF14259.1 CDF91215.1 - 1.4e-08 34.6 0.0 2.6e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.17 CDF91215.1 - 1e-06 28.2 0.1 2.2e-06 27.2 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF91215.1 - 0.00023 20.9 0.0 0.00053 19.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sec61_beta PF03911.11 CDF91216.1 - 3e-17 62.1 0.5 3.6e-17 61.8 0.4 1.1 1 0 0 1 1 1 1 Sec61beta family Cas_Csx9 PF09658.5 CDF91216.1 - 0.078 11.7 0.0 0.086 11.6 0.0 1.0 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csx9) tRNA-synt_2b PF00587.20 CDF91217.1 - 4.7e-32 110.9 0.0 7.9e-32 110.1 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2 PF00152.15 CDF91217.1 - 0.12 11.0 0.0 0.24 10.1 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class II (D, K and N) PALP PF00291.20 CDF91218.1 - 1.2e-71 241.4 0.1 1.5e-71 241.1 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.13 CDF91218.1 - 7.8e-42 140.7 0.0 1.3e-27 95.1 0.0 2.5 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase MMR1 PF08505.5 CDF91219.1 - 4.9e-52 177.3 67.3 9.8e-26 91.2 18.7 3.1 2 1 1 3 3 3 2 Mitochondrial Myo2 receptor-related protein PAT1 PF09770.4 CDF91219.1 - 0.00063 18.1 43.9 0.0011 17.3 30.5 1.4 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CDF91219.1 - 0.041 12.1 46.8 0.059 11.5 32.5 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Peroxin-13_N PF04088.8 CDF91220.1 - 5.2e-56 188.9 0.2 8.9e-56 188.2 0.1 1.4 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_1 PF00018.23 CDF91220.1 - 5.7e-09 35.2 0.0 9.8e-09 34.4 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.1 CDF91220.1 - 2.3e-07 30.2 0.0 3.7e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.6 CDF91220.1 - 0.051 13.7 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain Fn_bind PF02986.9 CDF91221.1 - 1.4 8.5 4.1 0.77 9.3 1.6 1.6 1 1 0 1 1 1 0 Fibronectin binding repeat FAD-oxidase_C PF02913.14 CDF91222.1 - 2.6e-60 203.8 0.0 4.9e-60 202.9 0.0 1.5 2 0 0 2 2 2 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 CDF91222.1 - 1.7e-37 128.0 0.0 3e-37 127.2 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain eIF3_subunit PF08597.5 CDF91223.1 - 1.3e-60 205.0 13.6 1.5e-60 204.7 9.4 1.1 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit DUF3602 PF12223.3 CDF91224.1 - 2.5e-21 75.8 14.5 9.9e-14 51.4 0.1 3.4 2 2 1 3 3 3 3 Protein of unknown function (DUF3602) DUF1633 PF07794.6 CDF91224.1 - 0.23 9.3 2.4 0.28 9.0 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1633) Glu_synthase PF01645.12 CDF91225.1 - 4.9e-157 522.5 0.0 8.8e-157 521.7 0.0 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase GATase_2 PF00310.16 CDF91225.1 - 3e-142 473.6 0.0 4.8e-142 472.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_syn_central PF04898.9 CDF91225.1 - 7.8e-115 383.0 0.0 3.4e-114 380.9 0.0 2.0 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.14 CDF91225.1 - 2.9e-56 189.6 2.0 5.2e-56 188.8 1.4 1.4 1 0 0 1 1 1 1 GXGXG motif Fer4_20 PF14691.1 CDF91225.1 - 4.3e-25 87.4 0.1 8.5e-25 86.5 0.1 1.5 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.9 CDF91225.1 - 1.5e-12 47.8 0.0 5.4e-12 46.0 0.0 2.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CDF91225.1 - 1.3e-07 31.5 0.0 4.4e-07 29.8 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CDF91225.1 - 1.5e-07 31.6 0.0 0.0034 17.4 0.0 2.6 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CDF91225.1 - 6.4e-06 26.4 0.1 0.00057 20.2 0.0 3.1 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 CDF91225.1 - 9.9e-05 20.9 1.4 0.00019 20.0 0.0 2.1 3 0 0 3 3 3 1 HI0933-like protein DAO PF01266.19 CDF91225.1 - 0.00018 20.5 0.1 0.0011 18.0 0.0 2.4 3 0 0 3 3 3 1 FAD dependent oxidoreductase Amino_oxidase PF01593.19 CDF91225.1 - 0.0002 20.5 0.2 0.0004 19.5 0.0 1.6 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.19 CDF91225.1 - 0.0024 16.7 0.0 0.0044 15.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 CDF91225.1 - 0.0045 16.1 0.0 0.0084 15.2 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.12 CDF91225.1 - 0.012 14.7 0.1 0.039 13.0 0.0 1.9 2 0 0 2 2 2 0 Thi4 family GATase_6 PF13522.1 CDF91225.1 - 0.012 15.5 0.0 0.049 13.6 0.0 2.0 1 1 0 1 1 1 0 Glutamine amidotransferase domain FAD_binding_3 PF01494.14 CDF91225.1 - 0.068 12.2 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain FMN_dh PF01070.13 CDF91225.1 - 3 6.5 6.3 1.4 7.7 1.4 2.4 3 0 0 3 3 3 0 FMN-dependent dehydrogenase Fungal_trans_2 PF11951.3 CDF91226.1 - 1.7e-72 244.1 4.7 1.7e-72 244.1 3.3 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF91226.1 - 6.7e-09 35.5 9.8 1.2e-08 34.6 6.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dickkopf_N PF04706.7 CDF91226.1 - 0.21 11.7 7.7 0.96 9.6 5.3 2.2 1 0 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region VID27 PF08553.5 CDF91226.1 - 0.36 8.9 4.7 0.53 8.4 3.2 1.1 1 0 0 1 1 1 0 VID27 cytoplasmic protein PRELI PF04707.9 CDF91227.1 - 1.2e-47 161.4 0.1 1.4e-47 161.2 0.1 1.0 1 0 0 1 1 1 1 PRELI-like family NMT PF01233.14 CDF91229.1 - 4e-81 270.3 0.1 6.4e-81 269.7 0.1 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.10 CDF91229.1 - 1.6e-77 259.1 0.3 3e-77 258.3 0.0 1.6 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Acetyltransf_9 PF13527.1 CDF91229.1 - 2e-06 27.6 0.0 1.1e-05 25.2 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 CDF91229.1 - 0.00018 21.6 0.0 0.024 14.7 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 CDF91229.1 - 0.0052 16.9 0.0 0.012 15.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CDF91229.1 - 0.036 14.0 0.0 0.073 13.1 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family WD40 PF00400.27 CDF91230.1 - 7.1e-14 51.0 7.3 2.1e-06 27.3 0.3 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.3 CDF91230.1 - 0.0037 15.4 1.0 0.017 13.2 0.2 2.0 2 0 0 2 2 2 1 Nucleoporin Nup120/160 PQQ_3 PF13570.1 CDF91230.1 - 0.0039 17.3 0.6 0.022 15.0 0.0 2.5 3 0 0 3 3 3 1 PQQ-like domain Nop PF01798.13 CDF91232.1 - 1.1e-59 199.9 0.0 2.4e-59 198.9 0.0 1.6 1 0 0 1 1 1 1 Putative snoRNA binding domain NOSIC PF08060.8 CDF91232.1 - 6.8e-27 93.0 0.2 1.9e-26 91.6 0.1 1.8 2 0 0 2 2 2 1 NOSIC (NUC001) domain NOP5NT PF08156.8 CDF91232.1 - 8.4e-24 83.5 0.2 8.4e-24 83.5 0.2 2.8 2 1 0 2 2 2 1 NOP5NT (NUC127) domain GAGA_bind PF06217.7 CDF91232.1 - 0.33 10.8 20.8 0.55 10.1 14.4 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family CDC45 PF02724.9 CDF91232.1 - 0.43 8.5 25.5 0.57 8.1 17.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DDHD PF02862.12 CDF91232.1 - 0.89 9.3 14.5 1.6 8.5 10.0 1.4 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.7 CDF91232.1 - 1.1 9.1 26.8 1.7 8.4 18.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RNase_H2-Ydr279 PF09468.5 CDF91232.1 - 1.3 8.1 24.8 3.2 6.8 17.2 1.7 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) Zip PF02535.17 CDF91232.1 - 7.1 5.5 10.1 9.7 5.0 7.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter POC1 PF10450.4 CDF91233.1 - 2.9e-87 291.9 0.0 3.2e-87 291.7 0.0 1.0 1 0 0 1 1 1 1 POC1 chaperone Prefoldin_2 PF01920.15 CDF91234.1 - 2.2e-21 75.5 13.0 2.4e-21 75.4 9.0 1.0 1 0 0 1 1 1 1 Prefoldin subunit Spc24 PF08286.6 CDF91234.1 - 0.011 15.4 10.3 0.11 12.1 0.8 2.0 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF4201 PF13870.1 CDF91234.1 - 0.012 15.0 6.9 0.17 11.2 0.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Snapin_Pallidin PF14712.1 CDF91234.1 - 0.034 14.4 6.8 0.091 13.0 0.2 2.3 2 1 0 2 2 2 0 Snapin/Pallidin DivIC PF04977.10 CDF91234.1 - 0.048 13.1 11.6 0.081 12.4 1.5 2.3 2 0 0 2 2 2 0 Septum formation initiator DUF1192 PF06698.6 CDF91234.1 - 0.06 13.1 1.9 0.1 12.4 0.1 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1192) YgaB PF14182.1 CDF91234.1 - 0.39 10.9 11.5 0.14 12.4 2.9 2.1 1 1 1 2 2 2 0 YgaB-like protein DUF1640 PF07798.6 CDF91234.1 - 0.47 10.4 6.6 1 9.3 3.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) PEARLI-4 PF05278.7 CDF91234.1 - 0.52 9.6 5.5 0.1 11.9 0.5 1.8 1 1 1 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) DUF1664 PF07889.7 CDF91234.1 - 3.1 7.5 5.5 2 8.2 0.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF3166 PF11365.3 CDF91234.1 - 3.2 8.2 9.2 1.1 9.7 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3166) Occludin_ELL PF07303.8 CDF91234.1 - 5.6 7.7 7.3 9.2 7.0 0.5 2.1 1 1 0 2 2 2 0 Occludin homology domain FlxA PF14282.1 CDF91234.1 - 6.9 6.6 13.7 1.3 9.0 2.7 2.4 1 1 0 2 2 2 0 FlxA-like protein Seryl_tRNA_N PF02403.17 CDF91234.1 - 8.1 6.5 11.2 9.3 6.3 2.3 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain COQ9 PF08511.6 CDF91235.1 - 1.2e-21 75.9 0.1 3e-21 74.7 0.1 1.7 1 0 0 1 1 1 1 COQ9 ADH_N PF08240.7 CDF91236.1 - 1.6e-27 95.3 4.2 1.6e-27 95.3 2.9 2.2 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 CDF91236.1 - 8.6e-22 77.0 0.4 1.7e-21 76.1 0.3 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 CDF91236.1 - 0.001 18.2 0.2 0.0017 17.5 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.13 CDF91236.1 - 0.0058 16.6 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain UDPG_MGDP_dh_N PF03721.9 CDF91236.1 - 0.016 14.5 0.0 0.028 13.8 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ELFV_dehydrog PF00208.16 CDF91236.1 - 0.034 13.7 1.7 0.06 12.9 1.2 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ThiF PF00899.16 CDF91236.1 - 0.066 13.0 0.2 0.38 10.5 0.1 2.1 2 0 0 2 2 2 0 ThiF family 3HCDH_N PF02737.13 CDF91236.1 - 0.076 12.6 0.1 0.14 11.7 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.12 CDF91236.1 - 0.098 13.0 0.4 0.35 11.3 0.1 2.1 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent AlaDh_PNT_C PF01262.16 CDF91236.1 - 0.15 11.6 2.3 0.17 11.3 0.4 2.0 2 1 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain zf-RanBP PF00641.13 CDF91237.1 - 6.2e-23 79.5 11.1 6e-12 44.4 1.0 2.5 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.17 CDF91237.1 - 6.4e-08 32.1 0.0 0.00081 18.9 0.0 2.6 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF91237.1 - 0.002 18.0 0.0 0.027 14.4 0.0 2.6 1 1 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) DZR PF12773.2 CDF91237.1 - 0.012 15.4 9.0 0.64 9.8 0.7 2.4 2 0 0 2 2 2 0 Double zinc ribbon zf-MIZ PF02891.15 CDF91237.1 - 0.13 11.8 3.2 6.8 6.2 0.1 2.5 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger GCC2_GCC3 PF07699.8 CDF91237.1 - 0.23 11.0 6.9 0.15 11.6 0.2 2.4 2 0 0 2 2 2 0 GCC2 and GCC3 Rubredoxin PF00301.15 CDF91237.1 - 1.2 9.0 11.2 1.4 8.8 0.4 3.1 2 1 1 3 3 3 0 Rubredoxin AAA_18 PF13238.1 CDF91238.1 - 2e-29 102.5 0.1 3.1e-29 101.9 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CDF91238.1 - 1.6e-14 54.7 0.2 2.3e-14 54.2 0.1 1.3 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.1 CDF91238.1 - 8.4e-05 22.5 0.0 0.00016 21.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CDF91238.1 - 0.00016 21.5 0.0 0.017 14.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.17 CDF91238.1 - 0.00017 21.7 0.1 0.0007 19.7 0.0 1.9 2 0 0 2 2 2 1 RNA helicase Thymidylate_kin PF02223.12 CDF91238.1 - 0.00027 20.3 0.0 0.25 10.6 0.0 2.1 2 0 0 2 2 2 2 Thymidylate kinase Zeta_toxin PF06414.7 CDF91238.1 - 0.0012 18.0 0.0 0.0024 17.0 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.1 CDF91238.1 - 0.0016 18.6 0.0 0.0031 17.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDF91238.1 - 0.002 18.1 0.1 0.0056 16.6 0.0 1.6 2 1 0 2 2 1 1 AAA ATPase domain ADK PF00406.17 CDF91238.1 - 0.0028 17.5 0.1 0.86 9.4 0.0 2.3 2 0 0 2 2 2 1 Adenylate kinase AAA PF00004.24 CDF91238.1 - 0.0049 17.0 0.0 0.0086 16.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.16 CDF91238.1 - 0.0064 15.6 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 CDF91238.1 - 0.007 16.0 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ABC_tran PF00005.22 CDF91238.1 - 0.013 15.7 0.8 0.13 12.5 0.6 2.1 1 1 0 1 1 1 0 ABC transporter KTI12 PF08433.5 CDF91238.1 - 0.014 14.6 0.0 0.05 12.8 0.0 1.8 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Cytidylate_kin2 PF13189.1 CDF91238.1 - 0.014 15.2 0.1 0.13 12.1 0.0 2.2 1 1 0 1 1 1 0 Cytidylate kinase-like family AAA_14 PF13173.1 CDF91238.1 - 0.019 14.8 0.0 0.041 13.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 CDF91238.1 - 0.027 14.2 0.0 0.043 13.5 0.0 1.3 1 0 0 1 1 1 0 Part of AAA domain Viral_helicase1 PF01443.13 CDF91238.1 - 0.047 13.2 0.0 0.073 12.5 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_10 PF12846.2 CDF91238.1 - 0.056 12.8 0.0 0.093 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain FtsK_SpoIIIE PF01580.13 CDF91238.1 - 0.057 12.8 0.3 0.17 11.3 0.1 1.7 1 1 1 2 2 2 0 FtsK/SpoIIIE family AAA_29 PF13555.1 CDF91238.1 - 0.058 12.9 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.10 CDF91238.1 - 0.058 12.0 0.0 0.075 11.7 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein NTPase_1 PF03266.10 CDF91238.1 - 0.064 12.9 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 NTPase tRNA_lig_kinase PF08303.6 CDF91238.1 - 0.07 12.9 0.1 5.3 6.8 0.0 2.2 2 0 0 2 2 2 0 tRNA ligase kinase domain ArgK PF03308.11 CDF91238.1 - 0.088 11.5 0.0 0.17 10.6 0.0 1.4 1 0 0 1 1 1 0 ArgK protein NOT2_3_5 PF04153.13 CDF91239.1 - 1.4e-34 118.8 1.8 1.8e-34 118.5 1.3 1.1 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family zf-Mss51 PF13824.1 CDF91240.1 - 1.2e-18 66.7 0.2 2.3e-18 65.7 0.2 1.5 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 YL1_C PF08265.6 CDF91240.1 - 0.0013 18.2 0.2 0.003 17.0 0.2 1.7 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Heme_oxygenase PF01126.15 CDF91241.1 - 3.2e-15 56.2 1.6 1.1e-14 54.5 1.1 1.9 1 1 0 1 1 1 1 Heme oxygenase DNA_ligase_A_M PF01068.16 CDF91242.1 - 8.3e-57 191.8 0.1 1.4e-56 191.0 0.1 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 CDF91242.1 - 4.7e-55 186.1 0.8 2.8e-54 183.6 0.0 2.2 2 0 0 2 2 2 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 CDF91242.1 - 3.1e-25 88.4 0.0 9.5e-25 86.8 0.0 1.9 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DNA_ligase_OB_2 PF14743.1 CDF91242.1 - 0.028 14.1 0.5 7.6 6.2 0.1 2.5 2 0 0 2 2 2 0 DNA ligase OB-like domain ENTH PF01417.15 CDF91243.1 - 2.5e-40 137.2 0.1 7.4e-40 135.6 0.0 1.9 2 0 0 2 2 2 1 ENTH domain Aconitase_2_N PF06434.8 CDF91243.1 - 0.32 10.3 3.5 0.15 11.4 0.1 2.0 2 0 0 2 2 2 0 Aconitate hydratase 2 N-terminus DUF4412 PF14371.1 CDF91243.1 - 0.39 11.2 3.4 1.4 9.5 1.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4412) Med15 PF09606.5 CDF91243.1 - 3.6 5.6 96.6 5.1 5.1 66.9 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal CENP-X PF09415.5 CDF91244.1 - 1.1e-26 92.3 0.8 1.3e-26 92.2 0.5 1.0 1 0 0 1 1 1 1 CENP-S associating Centromere protein X CBFD_NFYB_HMF PF00808.18 CDF91244.1 - 0.0055 16.7 0.0 0.0065 16.4 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.12 CDF91244.1 - 0.033 14.1 0.3 0.056 13.3 0.2 1.5 1 1 0 1 1 1 0 TATA box binding protein associated factor (TAF) Sel1 PF08238.7 CDF91245.1 - 4.4e-20 71.6 22.2 4.5e-05 23.9 0.1 9.8 11 0 0 11 11 11 5 Sel1 repeat TPR_12 PF13424.1 CDF91245.1 - 0.00038 20.3 2.6 1.5 8.8 0.0 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.1 CDF91245.1 - 0.021 14.4 13.1 0.074 12.7 0.3 4.5 5 1 0 5 5 5 0 TPR repeat DUF4407 PF14362.1 CDF91245.1 - 0.099 11.5 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_2 PF07719.12 CDF91245.1 - 0.11 12.5 9.9 3.2 7.8 0.1 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.1 CDF91245.1 - 0.59 10.8 9.5 2.1 9.1 0.1 4.9 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.1 CDF91245.1 - 0.61 10.0 13.6 25 4.9 0.1 5.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.1 CDF91245.1 - 4.5 7.9 12.3 52 4.6 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.23 CDF91245.1 - 5.9 6.6 18.5 1 9.0 0.1 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat WD40 PF00400.27 CDF91246.1 - 5.2e-43 143.4 19.8 9e-11 41.2 0.4 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIIIC_delta PF12657.2 CDF91246.1 - 0.0031 17.2 8.0 0.22 11.2 0.8 3.6 1 1 3 4 4 4 2 Transcription factor IIIC subunit delta N-term YmzC PF14157.1 CDF91246.1 - 0.0099 15.6 0.0 3.1 7.6 0.0 3.4 4 0 0 4 4 4 1 YmzC-like protein PNP_UDP_1 PF01048.15 CDF91247.1 - 8.7e-44 149.2 0.0 1e-43 148.9 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily DEAD PF00270.24 CDF91248.1 - 3.7e-41 140.4 0.1 5.8e-41 139.8 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF91248.1 - 1.8e-25 88.5 0.2 3.9e-25 87.5 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain WD40 PF00400.27 CDF91251.1 - 3e-09 36.4 7.4 0.00036 20.3 0.0 4.6 6 0 0 6 6 6 3 WD domain, G-beta repeat Cyclin_N PF00134.18 CDF91252.1 - 1e-44 151.1 0.3 2.1e-44 150.1 0.2 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 CDF91252.1 - 1.2e-28 99.4 0.1 3.7e-28 97.8 0.0 1.9 2 0 0 2 2 2 1 Cyclin, C-terminal domain Phage_Coat_A PF05357.8 CDF91252.1 - 0.046 13.3 0.0 0.12 12.0 0.0 1.7 1 0 0 1 1 1 0 Phage Coat Protein A Sas10 PF09368.5 CDF91253.1 - 1.5e-29 101.9 8.0 1.5e-29 101.9 5.5 2.6 2 0 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.10 CDF91253.1 - 4e-08 33.3 0.4 1.5e-07 31.5 0.3 2.0 1 0 0 1 1 1 1 Sas10/Utp3/C1D family RNA_pol_Rpc4 PF05132.9 CDF91254.1 - 8.2e-31 106.7 0.2 8.2e-31 106.7 0.1 2.9 3 0 0 3 3 3 1 RNA polymerase III RPC4 APG9 PF04109.11 CDF91255.1 - 3.5e-165 549.4 3.8 4.9e-165 548.9 2.7 1.2 1 0 0 1 1 1 1 Autophagy protein Apg9 Nop14 PF04147.7 CDF91256.1 - 1.2e-217 724.8 63.5 4.2e-128 428.6 7.6 2.0 1 1 1 2 2 2 2 Nop14-like family SapB_1 PF05184.10 CDF91256.1 - 0.031 14.1 0.0 1 9.2 0.0 3.0 2 0 0 2 2 2 0 Saposin-like type B, region 1 DUF3802 PF12290.3 CDF91256.1 - 0.039 14.2 7.1 2 8.7 2.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3802) DUF1687 PF07955.6 CDF91256.1 - 0.093 12.7 6.6 0.074 13.0 1.6 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1687) PCI PF01399.22 CDF91257.1 - 2e-19 69.8 0.1 7.5e-19 68.0 0.1 2.0 1 0 0 1 1 1 1 PCI domain PCI_Csn8 PF10075.4 CDF91257.1 - 0.0019 18.0 0.3 0.015 15.1 0.0 2.3 2 0 0 2 2 2 1 COP9 signalosome, subunit CSN8 DUF972 PF06156.8 CDF91258.1 - 0.018 15.4 4.0 2.3 8.6 1.3 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF972) TPR_16 PF13432.1 CDF91258.1 - 0.029 15.0 1.5 7.3 7.4 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Tup_N PF08581.5 CDF91258.1 - 0.035 14.2 1.2 0.2 11.8 0.3 2.2 2 0 0 2 2 2 0 Tup N-terminal MIT PF04212.13 CDF91258.1 - 0.038 13.8 0.4 0.038 13.8 0.3 2.2 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_12 PF13424.1 CDF91258.1 - 0.076 12.9 1.0 0.16 11.9 0.1 2.1 2 1 0 2 2 2 0 Tetratricopeptide repeat Spatacsin_C PF14649.1 CDF91258.1 - 0.1 11.4 1.5 0.9 8.3 0.1 2.0 2 0 0 2 2 2 0 Spatacsin C-terminus SpecificRecomb PF10136.4 CDF91258.1 - 0.11 10.5 1.1 0.13 10.3 0.1 1.6 2 0 0 2 2 2 0 Site-specific recombinase Snapin_Pallidin PF14712.1 CDF91258.1 - 0.13 12.6 4.6 4.6 7.6 0.0 2.5 2 0 0 2 2 2 0 Snapin/Pallidin Apolipoprotein PF01442.13 CDF91258.1 - 0.13 11.7 5.7 0.77 9.2 2.1 2.2 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain TPR_2 PF07719.12 CDF91258.1 - 0.18 11.8 1.0 0.34 10.9 0.1 2.0 2 0 0 2 2 1 0 Tetratricopeptide repeat DUF4200 PF13863.1 CDF91258.1 - 0.28 11.1 11.0 0.089 12.7 4.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) TBPIP PF07106.8 CDF91258.1 - 0.3 10.6 8.9 0.26 10.8 0.3 2.3 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) IncA PF04156.9 CDF91258.1 - 0.39 10.2 12.3 0.2 11.2 3.2 2.1 2 0 0 2 2 2 0 IncA protein Spectrin PF00435.16 CDF91258.1 - 0.4 11.0 9.5 0.32 11.2 2.6 2.4 2 1 0 2 2 2 0 Spectrin repeat Rootletin PF15035.1 CDF91258.1 - 0.45 10.4 13.3 7.3 6.5 9.2 2.7 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Mto2_bdg PF12808.2 CDF91258.1 - 1.9 8.6 7.8 0.76 9.9 0.9 3.1 3 0 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Seryl_tRNA_N PF02403.17 CDF91258.1 - 4.6 7.3 11.1 1.4 8.9 0.2 3.0 2 2 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Fib_alpha PF08702.5 CDF91258.1 - 5.8 7.0 9.3 6 6.9 0.5 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DivIC PF04977.10 CDF91258.1 - 9.9 5.7 8.0 19 4.7 1.7 2.7 2 1 0 2 2 2 0 Septum formation initiator DUF2013 PF09431.5 CDF91259.1 - 2.5e-42 143.9 15.3 6.5e-42 142.6 10.6 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2013) Tubulin PF00091.20 CDF91260.1 - 2.7e-70 236.5 0.0 4.1e-70 235.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.12 CDF91260.1 - 3e-21 75.7 0.0 5.4e-21 74.9 0.0 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.4 CDF91260.1 - 2.2e-06 27.6 0.0 4.9e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Coatomer_WDAD PF04053.9 CDF91261.1 - 1.5e-132 442.5 2.1 2.4e-132 441.9 1.5 1.3 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.6 CDF91261.1 - 7.7e-69 232.2 0.0 1.1e-68 231.7 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.27 CDF91261.1 - 2.8e-55 182.3 13.0 2e-10 40.0 0.0 7.0 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.3 CDF91261.1 - 4.6e-07 28.3 4.6 0.13 10.3 0.1 3.9 2 1 2 4 4 4 3 Nucleoporin Nup120/160 eIF2A PF08662.6 CDF91261.1 - 0.00074 19.2 0.2 6.2 6.4 0.0 3.7 3 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A TPR_1 PF00515.23 CDF91261.1 - 0.022 14.3 0.1 0.098 12.3 0.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat ENTH PF01417.15 CDF91261.1 - 0.03 14.1 0.2 0.089 12.6 0.1 1.8 1 0 0 1 1 1 0 ENTH domain TPR_11 PF13414.1 CDF91261.1 - 0.08 12.5 0.1 0.29 10.7 0.0 2.0 1 0 0 1 1 1 0 TPR repeat TEX19 PF15553.1 CDF91261.1 - 2.2 8.0 4.6 5 6.9 2.1 2.2 2 0 0 2 2 2 0 Testis-expressed protein 19 Tfb2 PF03849.9 CDF91262.1 - 7.2e-155 515.1 2.1 9.4e-155 514.7 1.5 1.1 1 0 0 1 1 1 1 Transcription factor Tfb2 Helicase_C_3 PF13625.1 CDF91262.1 - 5.8e-06 26.0 0.0 1.7e-05 24.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Mei5 PF10376.4 CDF91263.1 - 1.1e-36 126.4 19.5 1.3e-36 126.1 13.5 1.0 1 0 0 1 1 1 1 Double-strand recombination repair protein Pup PF05639.6 CDF91263.1 - 0.82 10.2 5.9 0.15 12.5 0.7 2.3 2 1 0 2 2 2 0 Pup-like protein Noc2 PF03715.8 CDF91264.1 - 6.2e-130 432.4 2.5 6.2e-130 432.4 1.7 2.6 3 1 1 4 4 4 1 Noc2p family DUF4025 PF13217.1 CDF91264.1 - 4.1 7.3 10.0 1 9.2 1.5 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4025) MMR_HSR1 PF01926.18 CDF91265.1 - 1.2e-07 31.6 0.1 6.5e-07 29.3 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF258 PF03193.11 CDF91265.1 - 8.5e-05 21.7 0.0 0.00018 20.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Ras PF00071.17 CDF91265.1 - 0.052 12.9 0.0 0.17 11.2 0.0 1.8 2 0 0 2 2 2 0 Ras family Miro PF08477.8 CDF91265.1 - 0.058 13.9 0.0 0.18 12.3 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein FeoB_N PF02421.13 CDF91265.1 - 0.17 11.1 0.2 0.49 9.6 0.0 1.9 2 0 0 2 2 2 0 Ferrous iron transport protein B APG6 PF04111.7 CDF91266.1 - 2.3e-109 365.2 11.9 2.9e-109 364.9 8.2 1.1 1 0 0 1 1 1 1 Autophagy protein Apg6 Atg14 PF10186.4 CDF91266.1 - 0.022 13.7 11.7 0.084 11.8 8.1 1.8 1 1 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 V_ATPase_I PF01496.14 CDF91266.1 - 0.089 10.6 5.7 0.13 10.0 3.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family IncA PF04156.9 CDF91266.1 - 0.36 10.4 13.0 0.79 9.2 9.0 1.6 1 0 0 1 1 1 0 IncA protein Ribonuc_red_lgC PF02867.10 CDF91267.1 - 6.4e-206 685.0 0.0 8.2e-206 684.7 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 CDF91267.1 - 4.5e-22 77.6 0.1 2e-21 75.5 0.0 2.1 2 0 0 2 2 2 1 Ribonucleotide reductase, all-alpha domain DEAD PF00270.24 CDF91268.1 - 1.4e-46 158.0 0.0 8.8e-45 152.2 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF91268.1 - 1.1e-27 95.6 0.1 3.1e-27 94.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDF91268.1 - 0.0019 18.0 0.0 0.0083 15.9 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 CDF91268.1 - 0.11 11.3 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 SNF2 family N-terminal domain CMS1 PF14617.1 CDF91268.1 - 0.15 11.0 0.0 0.32 10.0 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Helicase_C_2 PF13307.1 CDF91268.1 - 0.18 11.7 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 Helicase C-terminal domain DUF1253 PF06862.7 CDF91268.1 - 0.31 9.3 0.0 1.3 7.3 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1253) HSP20 PF00011.16 CDF91269.1 - 6.5e-18 64.4 0.6 6.5e-18 64.4 0.4 1.5 2 0 0 2 2 2 1 Hsp20/alpha crystallin family Mit_ribos_Mrp51 PF11709.3 CDF91270.1 - 6.7e-93 311.3 0.1 7.8e-93 311.1 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit IGPD PF00475.13 CDF91271.1 - 9.2e-60 200.7 0.2 1.4e-59 200.1 0.2 1.3 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase DUF3943 PF13084.1 CDF91271.1 - 0.13 11.7 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3943) SpoU_methylase PF00588.14 CDF91272.1 - 3.7e-28 98.1 0.0 7.8e-28 97.1 0.0 1.6 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.7 CDF91272.1 - 3.8e-14 52.6 0.0 8.5e-14 51.4 0.0 1.6 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding NUDIX PF00293.23 CDF91273.1 - 5.8e-27 93.9 0.0 8e-27 93.5 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Baculo_PEP_C PF04513.7 CDF91274.1 - 0.00037 20.3 27.2 1.4 8.7 0.9 5.2 2 1 3 5 5 5 5 Baculovirus polyhedron envelope protein, PEP, C terminus DUF342 PF03961.8 CDF91274.1 - 0.002 16.6 15.2 0.002 16.6 10.6 4.0 2 1 1 3 3 3 1 Protein of unknown function (DUF342) Peptidase_C14 PF00656.17 CDF91275.1 - 3e-68 230.1 0.0 3.8e-68 229.8 0.0 1.0 1 0 0 1 1 1 1 Caspase domain Hist_deacetyl PF00850.14 CDF91276.1 - 9.3e-66 222.2 0.1 1.3e-65 221.7 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Radical_SAM PF04055.16 CDF91277.1 - 4.6e-13 49.6 0.0 7.5e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Spore_GerAC PF05504.6 CDF91277.1 - 0.15 11.8 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal Kinetocho_Slk19 PF12709.2 CDF91278.1 - 2e-29 101.4 13.7 2e-29 101.4 9.5 8.5 3 1 6 10 10 10 1 Central kinetochore-associated DUF2721 PF11026.3 CDF91278.1 - 9.9 5.8 5.4 2.1 7.9 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) TFIIA PF03153.8 CDF91279.1 - 1.9e-56 192.5 15.1 1.6e-34 120.4 4.2 2.1 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit 2-Hacid_dh_C PF02826.14 CDF91280.1 - 4.5e-35 120.3 0.0 6.9e-35 119.8 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.10 CDF91280.1 - 0.00039 20.2 0.0 0.001 18.9 0.0 1.6 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh PF00389.25 CDF91280.1 - 0.085 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain PEX11 PF05648.9 CDF91281.1 - 4.9e-06 25.9 3.8 1.8e-05 24.1 2.6 1.8 1 1 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Arginase PF00491.16 CDF91282.1 - 1.2e-74 251.1 0.0 1.4e-74 250.9 0.0 1.0 1 0 0 1 1 1 1 Arginase family GDPD PF03009.12 CDF91284.1 - 5.1e-83 278.4 0.2 9.1e-83 277.6 0.1 1.4 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family SPX PF03105.14 CDF91284.1 - 1.2e-37 130.1 9.5 1.2e-37 130.1 6.6 2.6 2 1 0 2 2 2 1 SPX domain Ank_2 PF12796.2 CDF91284.1 - 2.3e-27 95.1 1.5 7.3e-15 55.0 0.0 4.7 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank PF00023.25 CDF91284.1 - 7.1e-25 85.5 2.2 0.00048 19.8 0.0 7.2 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.1 CDF91284.1 - 1.9e-20 72.7 0.2 2.8e-08 34.0 0.0 4.8 4 0 0 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDF91284.1 - 1.9e-17 61.6 4.7 0.049 13.8 0.1 8.2 8 0 0 8 8 8 5 Ankyrin repeat Ank_5 PF13857.1 CDF91284.1 - 6.1e-16 58.0 1.6 0.022 15.0 0.0 6.3 2 1 4 6 6 6 5 Ankyrin repeats (many copies) ABC1 PF03109.11 CDF91285.1 - 2.5e-19 69.3 0.0 6e-19 68.1 0.0 1.7 1 0 0 1 1 1 1 ABC1 family Aspzincin_M35 PF14521.1 CDF91285.1 - 0.012 16.1 0.0 0.026 15.0 0.0 1.5 1 0 0 1 1 1 0 Lysine-specific metallo-endopeptidase Arf PF00025.16 CDF91286.1 - 6.7e-76 253.3 0.1 7.6e-76 253.2 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 CDF91286.1 - 1e-11 44.3 0.0 1.3e-11 44.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 CDF91286.1 - 3.5e-11 42.7 0.0 4e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.7 CDF91286.1 - 1.8e-10 40.3 0.0 2.2e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.15 CDF91286.1 - 4.5e-10 38.7 0.3 1.8e-06 26.9 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Miro PF08477.8 CDF91286.1 - 3.3e-09 37.2 0.0 5e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Miro-like protein GTP_EFTU PF00009.22 CDF91286.1 - 2.4e-05 23.8 0.2 0.00037 19.9 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CDF91286.1 - 0.00032 20.6 0.1 0.00047 20.0 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.22 CDF91286.1 - 0.00049 20.4 0.3 0.002 18.4 0.2 1.8 1 1 0 1 1 1 1 ABC transporter ArgK PF03308.11 CDF91286.1 - 0.0019 17.0 1.5 0.14 10.8 0.4 2.9 2 1 0 2 2 2 1 ArgK protein SRP54 PF00448.17 CDF91286.1 - 0.074 12.4 0.3 0.55 9.6 0.1 2.0 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain cobW PF02492.14 CDF91286.1 - 0.11 11.9 0.8 4.5 6.6 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain BPL_LplA_LipB PF03099.14 CDF91287.1 - 1e-20 74.0 0.1 2.3e-20 72.8 0.0 1.6 2 0 0 2 2 2 1 Biotin/lipoate A/B protein ligase family WD40 PF00400.27 CDF91288.1 - 0.00057 19.6 4.0 0.57 10.1 0.0 4.4 5 0 0 5 5 5 3 WD domain, G-beta repeat Mgm101p PF06420.7 CDF91289.1 - 2.5e-90 300.3 0.1 3e-90 300.0 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 Rad52_Rad22 PF04098.10 CDF91289.1 - 0.013 15.2 0.0 0.023 14.4 0.0 1.5 1 1 0 1 1 1 0 Rad52/22 family double-strand break repair protein PMT PF02366.13 CDF91290.1 - 1.2e-75 254.0 24.5 1.2e-75 254.0 17.0 1.8 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.14 CDF91290.1 - 8.1e-22 77.6 0.0 1.3e-21 76.9 0.0 1.3 1 0 0 1 1 1 1 MIR domain NUDIX PF00293.23 CDF91291.1 - 0.0022 17.6 0.0 0.0042 16.7 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain DHHA2 PF02833.9 CDF91292.1 - 1.2e-22 80.5 0.6 2.4e-22 79.4 0.4 1.5 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.15 CDF91292.1 - 1.8e-13 50.3 0.2 3.4e-13 49.4 0.1 1.4 1 0 0 1 1 1 1 DHH family HECT_2 PF09814.4 CDF91293.1 - 7.1e-60 202.5 1.5 8e-60 202.4 1.0 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Homoserine_dh PF00742.14 CDF91295.1 - 1.8e-56 190.6 0.1 2.4e-56 190.2 0.0 1.2 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.11 CDF91295.1 - 4.3e-19 69.0 0.0 7e-19 68.3 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain DUF3608 PF12257.3 CDF91296.1 - 6.9e-138 458.2 1.7 1.2e-137 457.4 1.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3608) DEP PF00610.16 CDF91296.1 - 7.3e-26 89.7 0.1 1.7e-25 88.5 0.1 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) VWA_2 PF13519.1 CDF91297.1 - 4.1e-08 33.5 0.0 5.5e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.9 CDF91297.1 - 2.1e-07 30.7 0.2 3.2e-07 30.1 0.1 1.2 1 0 0 1 1 1 1 Ssl1-like FliT PF05400.8 CDF91298.1 - 0.027 14.8 0.9 0.027 14.8 0.6 1.1 1 0 0 1 1 1 0 Flagellar protein FliT NIR_SIR PF01077.17 CDF91299.1 - 2.5e-52 176.3 0.1 1.8e-45 154.1 0.0 3.1 3 0 0 3 3 3 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.12 CDF91299.1 - 6.3e-28 96.2 0.1 1.2e-12 47.2 0.0 2.6 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.20 CDF91299.1 - 1e-25 90.4 0.0 1.9e-25 89.5 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin Chalcone PF02431.10 CDF91300.1 - 1.7e-55 187.5 0.0 2.4e-55 187.0 0.0 1.2 1 0 0 1 1 1 1 Chalcone-flavanone isomerase DUF2454 PF10521.4 CDF91301.1 - 8.3e-65 218.5 0.3 1.1e-64 218.2 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2454) zf-Tim10_DDP PF02953.10 CDF91302.1 - 2.5e-22 77.9 1.3 3e-22 77.6 0.9 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF1767 PF08585.7 CDF91302.1 - 0.11 12.7 0.4 0.29 11.4 0.1 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF1767) RIX1 PF08167.7 CDF91304.1 - 9.1e-42 142.5 4.1 9.1e-42 142.5 2.8 2.6 2 1 1 3 3 3 1 rRNA processing/ribosome biogenesis TMF_TATA_bd PF12325.3 CDF91305.1 - 2.9e-33 114.1 17.0 2.9e-33 114.1 11.8 6.0 2 1 3 6 6 6 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.3 CDF91305.1 - 1.6e-12 47.0 7.9 1.6e-12 47.0 5.5 9.3 5 3 3 8 8 8 2 TATA element modulatory factor 1 DNA binding DUF812 PF05667.6 CDF91305.1 - 0.00028 19.5 11.8 0.00028 19.5 8.2 3.7 1 1 2 3 3 3 1 Protein of unknown function (DUF812) Seryl_tRNA_N PF02403.17 CDF91305.1 - 0.00059 19.8 7.7 0.00059 19.8 5.3 7.7 3 2 4 7 7 7 1 Seryl-tRNA synthetase N-terminal domain Tetrabrachion PF11401.3 CDF91306.1 - 0.063 13.0 0.3 3.4 7.5 0.1 2.6 2 0 0 2 2 2 0 Tetrabrachion IBN_N PF03810.14 CDF91307.1 - 1.2e-13 50.7 0.2 8.5e-13 48.0 0.0 2.7 3 0 0 3 3 3 1 Importin-beta N-terminal domain Cse1 PF08506.5 CDF91307.1 - 0.0003 19.4 0.2 0.0012 17.5 0.0 2.1 2 0 0 2 2 2 1 Cse1 MDM31_MDM32 PF08118.6 CDF91309.1 - 4.1e-272 903.0 4.3 4.7e-272 902.8 3.0 1.0 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins NAC PF01849.13 CDF91310.1 - 6.8e-19 67.1 0.2 1.6e-18 65.9 0.0 1.7 2 0 0 2 2 2 1 NAC domain UBA PF00627.26 CDF91310.1 - 2.4e-05 24.0 0.0 5e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain DUF2296 PF10058.4 CDF91311.1 - 5.7e-11 41.9 0.3 9.8e-11 41.2 0.2 1.4 1 0 0 1 1 1 1 Predicted integral membrane metal-binding protein (DUF2296) DUF3180 PF11377.3 CDF91311.1 - 0.0069 16.2 0.1 0.0097 15.7 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3180) DUF964 PF06133.6 CDF91311.1 - 0.013 15.5 2.4 0.013 15.5 1.7 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF964) OmpH PF03938.9 CDF91311.1 - 0.021 14.7 0.6 0.021 14.7 0.4 2.0 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) HAP1_N PF04849.8 CDF91311.1 - 0.029 13.3 0.2 0.029 13.3 0.2 2.1 2 0 0 2 2 2 0 HAP1 N-terminal conserved region YoqO PF14037.1 CDF91311.1 - 0.031 14.3 0.2 0.047 13.7 0.1 1.2 1 0 0 1 1 1 0 YoqO-like protein DUF3630 PF12305.3 CDF91311.1 - 0.042 13.7 0.0 0.08 12.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3630) Seryl_tRNA_N PF02403.17 CDF91311.1 - 0.12 12.4 9.6 3.7 7.5 0.1 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DivIVA PF05103.8 CDF91311.1 - 0.53 10.3 7.3 3.5 7.6 0.1 2.2 2 0 0 2 2 2 0 DivIVA protein Allexi_40kDa PF05549.6 CDF91311.1 - 1.1 8.4 4.7 1.3 8.1 0.3 2.0 2 0 0 2 2 2 0 Allexivirus 40kDa protein DUF342 PF03961.8 CDF91311.1 - 1.3 7.3 6.0 7.6 4.8 1.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF342) Helicase_IV_N PF12462.3 CDF91311.1 - 1.8 8.1 6.8 12 5.4 0.3 2.8 3 0 0 3 3 3 0 DNA helicase IV / RNA helicase N terminal Ctf8 PF09696.5 CDF91312.1 - 1.3e-25 89.5 0.0 1.9e-25 89.0 0.0 1.2 1 0 0 1 1 1 1 Ctf8 Glyco_hydro_47 PF01532.15 CDF91313.1 - 7.6e-139 463.2 0.2 8.7e-139 463.0 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Cys_Met_Meta_PP PF01053.15 CDF91314.1 - 3.1e-28 98.1 0.0 2.5e-27 95.1 0.0 2.0 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.16 CDF91314.1 - 0.0027 16.7 0.1 0.0088 15.0 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class I and II PDE6_gamma PF04868.7 CDF91314.1 - 0.063 13.1 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Retinal cGMP phosphodiesterase, gamma subunit ATP-synt_J PF04911.7 CDF91315.1 - 3.2e-24 84.1 1.8 3.5e-24 83.9 1.3 1.0 1 0 0 1 1 1 1 ATP synthase j chain Allantoicase PF03561.10 CDF91316.1 - 4.3e-94 311.9 0.3 4.8e-54 181.9 0.0 2.8 2 1 0 2 2 2 2 Allantoicase repeat FMN_red PF03358.10 CDF91318.1 - 2.4e-29 101.8 0.0 3.1e-29 101.4 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.12 CDF91318.1 - 1.9e-06 27.5 0.0 2.4e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold RAG2_PHD PF13341.1 CDF91318.1 - 0.058 13.3 0.2 4.4 7.3 0.1 2.3 2 0 0 2 2 2 0 RAG2 PHD domain SCRL PF06876.7 CDF91319.1 - 0.25 11.3 6.2 0.24 11.3 3.7 1.6 1 1 0 1 1 1 0 Plant self-incompatibility response (SCRL) protein DUF1708 PF08101.6 CDF91320.1 - 4.8e-43 147.5 0.4 6.8e-43 147.0 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) Dus PF01207.12 CDF91321.1 - 5.8e-56 189.5 0.0 3e-55 187.2 0.0 1.9 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) SLA_LP_auto_ag PF05889.8 CDF91321.1 - 0.0021 16.5 0.0 0.0031 16.0 0.0 1.2 1 0 0 1 1 1 1 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) TMP-TENI PF02581.12 CDF91321.1 - 0.03 13.4 0.0 0.054 12.6 0.0 1.4 1 0 0 1 1 1 0 Thiamine monophosphate synthase/TENI ThiC PF01964.13 CDF91321.1 - 0.066 11.7 0.1 5.5 5.3 0.0 2.1 1 1 1 2 2 2 0 ThiC family FMN_dh PF01070.13 CDF91321.1 - 0.13 11.0 0.0 0.21 10.3 0.0 1.3 1 0 0 1 1 1 0 FMN-dependent dehydrogenase His_biosynth PF00977.16 CDF91321.1 - 0.15 11.2 0.0 0.26 10.5 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein ACC_central PF08326.7 CDF91322.1 - 1.3e-263 876.4 0.0 1.6e-263 876.0 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.17 CDF91322.1 - 2.6e-175 583.4 0.0 3.5e-175 583.0 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.12 CDF91322.1 - 4e-51 173.3 0.4 2.4e-50 170.7 0.0 2.2 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 CDF91322.1 - 1e-25 89.9 0.1 2.4e-25 88.7 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 CDF91322.1 - 1.7e-20 73.0 0.0 7.7e-20 70.8 0.0 2.2 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.17 CDF91322.1 - 2.8e-17 62.1 0.9 1e-16 60.2 0.1 2.4 2 0 0 2 2 2 1 Biotin-requiring enzyme ATP-grasp_4 PF13535.1 CDF91322.1 - 1.6e-10 40.9 0.0 6.9e-10 38.9 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 CDF91322.1 - 1.4e-07 30.6 0.0 1.8e-05 23.6 0.0 3.0 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 CDF91322.1 - 7.7e-05 22.1 0.0 0.00032 20.1 0.0 2.1 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.1 CDF91322.1 - 0.0018 17.9 0.1 0.16 11.6 0.0 2.5 1 1 1 2 2 2 1 Biotin-lipoyl like RnfC_N PF13375.1 CDF91322.1 - 0.0019 17.9 0.0 0.0062 16.2 0.0 1.8 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain ATP-grasp_3 PF02655.9 CDF91322.1 - 0.0056 16.5 0.0 0.033 14.0 0.0 2.2 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp PF02222.17 CDF91322.1 - 0.064 12.5 0.0 0.16 11.2 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain Tim17 PF02466.14 CDF91324.1 - 1.5e-28 99.3 2.0 1.9e-28 99.0 1.4 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Peptidase_S8 PF00082.17 CDF91325.1 - 6.1e-45 153.5 1.4 6.1e-45 153.5 1.0 1.6 2 0 0 2 2 2 1 Subtilase family Inhibitor_I9 PF05922.11 CDF91325.1 - 0.0017 18.8 0.0 0.004 17.6 0.0 1.7 1 0 0 1 1 1 1 Peptidase inhibitor I9 HIG_1_N PF04588.8 CDF91326.1 - 9.4e-05 22.0 2.9 0.00027 20.6 2.0 1.8 1 1 0 1 1 1 1 Hypoxia induced protein conserved region Ribosomal_L19 PF01245.15 CDF91327.1 - 2.9e-11 43.1 0.1 4.5e-11 42.5 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L19 WBS_methylT PF12589.3 CDF91328.1 - 9.2e-18 64.5 5.7 1.8e-17 63.5 3.9 1.5 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.7 CDF91328.1 - 1.7e-12 47.6 0.0 5.1e-12 46.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDF91328.1 - 3.6e-07 30.0 0.0 5e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDF91328.1 - 1.3e-06 28.0 0.0 3.9e-06 26.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 CDF91328.1 - 1.7e-06 28.3 0.0 3.7e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDF91328.1 - 8.3e-06 26.1 0.1 4.5e-05 23.8 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain CMAS PF02353.15 CDF91328.1 - 2.5e-05 23.5 0.0 0.00016 20.8 0.0 2.2 2 1 0 2 2 2 1 Mycolic acid cyclopropane synthetase MetW PF07021.7 CDF91328.1 - 0.00015 21.2 0.0 0.00023 20.6 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_18 PF12847.2 CDF91328.1 - 0.00017 22.1 0.0 0.00074 20.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 CDF91328.1 - 0.00048 19.7 0.0 0.0024 17.4 0.0 1.9 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_26 PF13659.1 CDF91328.1 - 0.0014 18.6 0.0 0.0042 17.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 CDF91328.1 - 0.026 13.6 0.0 0.062 12.4 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MBOAT PF03062.14 CDF91329.1 - 1e-61 208.8 42.6 2.3e-61 207.7 29.6 1.5 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.1 CDF91329.1 - 0.00093 19.2 5.2 0.00093 19.2 3.6 1.9 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family Peptidase_M76 PF09768.4 CDF91330.1 - 1.9e-77 258.6 1.8 2.3e-77 258.3 1.3 1.1 1 0 0 1 1 1 1 Peptidase M76 family SprT-like PF10263.4 CDF91330.1 - 0.0013 18.4 1.1 0.19 11.3 0.0 2.3 2 0 0 2 2 2 2 SprT-like family Tox-MPTase2 PF15638.1 CDF91330.1 - 0.11 12.0 0.1 0.18 11.2 0.1 1.3 1 0 0 1 1 1 0 Metallopeptidase toxin 2 Ank_5 PF13857.1 CDF91331.1 - 1.3e-14 53.8 0.1 3.6e-11 42.9 0.1 2.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.2 CDF91331.1 - 1.9e-10 40.9 0.1 1.1e-09 38.5 0.0 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.1 CDF91331.1 - 8.5e-10 38.8 0.9 2.7e-05 24.5 0.1 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.1 CDF91331.1 - 4.5e-08 32.5 0.7 0.0016 18.4 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.25 CDF91331.1 - 1.1e-07 31.2 3.2 0.0011 18.6 0.0 3.7 4 0 0 4 4 4 3 Ankyrin repeat DUF1682 PF07946.9 CDF91332.1 - 1.9e-74 250.4 4.3 2.3e-74 250.1 3.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) NMT_C PF02799.10 CDF91332.1 - 0.013 14.8 1.2 0.046 13.0 0.5 2.0 1 1 1 2 2 2 0 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Ribosomal_L9_N PF01281.14 CDF91333.1 - 6.2e-06 25.3 0.2 5.2e-05 22.3 0.1 2.3 1 1 0 1 1 1 1 Ribosomal protein L9, N-terminal domain IFT57 PF10498.4 CDF91333.1 - 0.0024 16.6 0.7 0.0028 16.4 0.5 1.1 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 A2M_recep PF07677.9 CDF91333.1 - 0.015 15.4 0.2 0.077 13.1 0.1 2.0 2 0 0 2 2 2 0 A-macroglobulin receptor Meth_synt_2 PF01717.13 CDF91333.1 - 0.04 12.8 0.1 0.053 12.4 0.1 1.2 1 0 0 1 1 1 0 Cobalamin-independent synthase, Catalytic domain MCC-bdg_PDZ PF10506.4 CDF91334.1 - 0.0015 18.3 1.2 0.15 11.8 0.2 2.5 2 0 0 2 2 2 2 PDZ domain of MCC-2 bdg protein for Usher syndrome SWIB PF02201.13 CDF91334.1 - 0.03 13.9 0.1 0.29 10.8 0.0 2.5 3 0 0 3 3 3 0 SWIB/MDM2 domain Thr_synth_N PF14821.1 CDF91335.1 - 6.7e-28 96.5 0.0 2.1e-27 94.9 0.0 1.9 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.20 CDF91335.1 - 9.9e-16 57.8 0.0 1.6e-15 57.1 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Atx10homo_assoc PF09759.4 CDF91336.1 - 4.8e-35 119.3 0.3 1.7e-34 117.6 0.2 2.0 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain Plant_tran PF04827.9 CDF91336.1 - 0.0027 17.1 0.1 0.01 15.2 0.0 1.9 2 0 0 2 2 2 1 Plant transposon protein WD40 PF00400.27 CDF91337.1 - 9e-53 174.3 19.0 3.8e-12 45.6 0.0 11.5 11 0 0 11 11 11 7 WD domain, G-beta repeat Utp12 PF04003.7 CDF91337.1 - 2.3e-27 95.0 0.1 3.8e-27 94.3 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family eIF2A PF08662.6 CDF91337.1 - 1.8e-06 27.8 1.4 0.049 13.3 0.0 6.0 4 3 1 6 6 6 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 CDF91337.1 - 6.2e-06 24.6 3.0 0.5 8.4 0.0 3.9 2 1 1 4 4 4 3 Nucleoporin Nup120/160 Nbas_N PF15492.1 CDF91337.1 - 0.00028 20.0 0.2 4 6.4 0.0 4.1 3 1 0 3 3 3 2 Neuroblastoma-amplified sequence, N terminal TFIIA PF03153.8 CDF91337.1 - 0.025 14.4 0.7 0.039 13.8 0.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Cytochrom_D1 PF02239.11 CDF91337.1 - 0.1 10.8 2.1 4.2 5.5 0.0 3.6 3 2 1 5 5 5 0 Cytochrome D1 heme domain Proteasome_A_N PF10584.4 CDF91337.1 - 0.33 10.3 4.6 2.5 7.4 0.2 4.0 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature MPP6 PF10175.4 CDF91338.1 - 0.05 13.9 2.5 0.1 12.9 1.7 1.6 1 1 0 1 1 1 0 M-phase phosphoprotein 6 UPF0029 PF01205.14 CDF91339.1 - 1.2e-24 86.1 0.0 1.6e-24 85.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.17 CDF91339.1 - 3.4e-09 36.5 0.0 7.6e-09 35.4 0.0 1.6 1 1 0 1 1 1 1 RWD domain Ytp1 PF10355.4 CDF91340.1 - 8e-109 363.0 5.9 1.5e-108 362.1 4.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.4 CDF91340.1 - 8.1e-32 108.9 5.3 2.6e-31 107.3 3.7 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF2427) G10 PF01125.12 CDF91341.1 - 6e-58 194.5 5.5 6.6e-58 194.3 3.8 1.0 1 0 0 1 1 1 1 G10 protein Fork_head PF00250.13 CDF91342.1 - 1.3e-36 124.4 0.1 3.1e-36 123.2 0.1 1.6 1 0 0 1 1 1 1 Fork head domain SAP PF02037.22 CDF91343.1 - 1.1e-08 34.3 0.0 2.7e-08 33.1 0.0 1.7 1 0 0 1 1 1 1 SAP domain zf-C3HC4 PF00097.20 CDF91343.1 - 1.2e-08 34.4 15.8 1.2e-08 34.4 10.9 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.1 CDF91343.1 - 2.1e-07 30.8 20.1 7.6e-07 29.0 11.3 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CDF91343.1 - 1.6e-06 27.8 18.8 1.4e-05 24.8 10.4 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.1 CDF91343.1 - 4.7e-06 26.1 15.5 2e-05 24.1 7.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.1 CDF91343.1 - 1.2e-05 24.9 6.6 1.2e-05 24.9 4.6 2.0 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.1 CDF91343.1 - 4.9e-05 22.9 18.5 0.00015 21.4 9.5 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.1 CDF91343.1 - 9.1e-05 22.2 12.5 9.1e-05 22.2 8.7 2.7 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.2 CDF91343.1 - 0.0093 16.0 9.0 0.015 15.3 4.1 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger U-box PF04564.10 CDF91343.1 - 0.023 14.6 0.1 0.16 11.9 0.0 2.4 2 0 0 2 2 2 0 U-box domain Mob_synth_C PF06463.8 CDF91343.1 - 0.028 14.0 1.9 0.079 12.6 1.3 1.8 1 0 0 1 1 1 0 Molybdenum Cofactor Synthesis C MCPVI PF02993.9 CDF91343.1 - 0.29 11.2 0.0 0.29 11.2 0.0 1.9 2 1 0 2 2 2 0 Minor capsid protein VI zf-RING_UBOX PF13445.1 CDF91343.1 - 0.34 10.6 17.9 0.096 12.4 8.0 2.8 2 0 0 2 2 2 0 RING-type zinc-finger GAGA PF09237.6 CDF91343.1 - 0.42 10.2 3.1 0.61 9.7 0.2 2.5 2 0 0 2 2 2 0 GAGA factor RecR PF02132.10 CDF91343.1 - 1 8.8 7.6 4.5 6.7 0.0 3.4 3 0 0 3 3 3 0 RecR protein zf-Nse PF11789.3 CDF91343.1 - 8.3 6.0 13.3 11 5.6 6.7 2.7 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit WD40 PF00400.27 CDF91344.1 - 4.2e-05 23.2 0.0 0.0014 18.4 0.0 3.4 2 0 0 2 2 2 1 WD domain, G-beta repeat DUF2963 PF11178.3 CDF91344.1 - 0.0051 16.2 0.1 0.015 14.7 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2963) Phos_pyr_kin PF08543.7 CDF91345.1 - 5.6e-09 35.5 0.0 7.4e-09 35.1 0.0 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.19 CDF91345.1 - 2.6e-05 23.5 0.0 0.00068 18.8 0.0 2.1 2 0 0 2 2 2 2 pfkB family carbohydrate kinase Lipase_3 PF01764.20 CDF91346.1 - 3.3e-07 29.9 0.0 6e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.2 CDF91346.1 - 0.00017 21.3 0.0 0.00083 19.1 0.0 2.0 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CDF91346.1 - 0.013 15.4 0.0 0.025 14.4 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family UPF0227 PF05728.7 CDF91346.1 - 0.024 14.3 0.0 0.041 13.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) DUF2974 PF11187.3 CDF91346.1 - 0.11 11.7 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Zn_clus PF00172.13 CDF91347.1 - 4.9e-06 26.3 3.6 9.8e-06 25.3 2.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pro_isomerase PF00160.16 CDF91348.1 - 8.6e-27 94.2 0.0 1.4e-26 93.5 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD cobW PF02492.14 CDF91349.1 - 7.4e-40 136.2 0.0 1.3e-39 135.4 0.0 1.4 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.1 CDF91349.1 - 0.00013 22.2 0.3 0.00044 20.5 0.1 2.0 2 1 0 2 2 2 1 AAA domain CobW_C PF07683.9 CDF91349.1 - 0.00016 21.3 0.0 0.00028 20.5 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain MobB PF03205.9 CDF91349.1 - 0.0098 15.5 0.0 0.021 14.5 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_29 PF13555.1 CDF91349.1 - 0.011 15.1 0.1 0.031 13.7 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.18 CDF91349.1 - 0.013 15.5 0.0 0.046 13.6 0.0 2.0 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_33 PF13671.1 CDF91349.1 - 0.014 15.2 0.1 0.048 13.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 CDF91349.1 - 0.016 16.0 0.2 0.041 14.6 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 CDF91349.1 - 0.019 14.9 0.0 0.035 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.1 CDF91349.1 - 0.019 14.8 0.0 0.064 13.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.22 CDF91349.1 - 0.067 12.6 0.1 0.53 9.6 0.1 2.2 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_5 PF07728.9 CDF91349.1 - 0.093 12.4 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Arch_ATPase PF01637.13 CDF91349.1 - 0.1 12.2 0.1 0.25 10.9 0.0 1.7 2 0 0 2 2 2 0 Archaeal ATPase AAA_28 PF13521.1 CDF91349.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.22 CDF91349.1 - 0.13 12.5 0.7 0.55 10.5 0.3 2.0 1 1 0 1 1 1 0 ABC transporter Glyco_transf_22 PF03901.12 CDF91350.1 - 1.8e-28 99.6 12.6 2.2e-28 99.3 8.7 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Img2 PF05046.9 CDF91351.1 - 1.3e-25 89.4 0.1 2.4e-25 88.5 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) DUF3294 PF07957.6 CDF91351.1 - 0.0058 16.2 0.0 0.0087 15.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3294) WD40 PF00400.27 CDF91352.1 - 1.1e-85 278.6 31.8 6.3e-15 54.4 0.1 8.4 8 0 0 8 8 8 8 WD domain, G-beta repeat eIF2A PF08662.6 CDF91352.1 - 7.3e-10 38.8 0.3 0.00036 20.2 0.0 3.6 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.3 CDF91352.1 - 8e-08 30.8 7.5 0.17 9.9 0.0 5.5 3 1 3 6 6 6 3 Nucleoporin Nup120/160 NLE PF08154.7 CDF91352.1 - 1.7e-06 27.9 0.0 2.9e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain Nucleoporin_N PF08801.6 CDF91352.1 - 0.00044 19.1 0.4 0.078 11.7 0.2 2.6 2 1 0 2 2 2 2 Nup133 N terminal like Nbas_N PF15492.1 CDF91352.1 - 0.002 17.2 1.6 0.52 9.3 0.1 3.2 2 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Gmad1 PF10647.4 CDF91352.1 - 0.0053 16.1 0.3 0.034 13.5 0.0 2.1 2 0 0 2 2 2 1 Lipoprotein LpqB beta-propeller domain PD40 PF07676.7 CDF91352.1 - 0.0077 15.8 0.1 2.6 7.7 0.0 2.9 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.11 CDF91352.1 - 0.0098 14.2 0.1 0.5 8.6 0.0 3.0 3 1 1 4 4 4 2 Cytochrome D1 heme domain Pkinase PF00069.20 CDF91353.1 - 1.4e-61 207.8 0.0 1.4e-61 207.8 0.0 2.4 3 1 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF91353.1 - 1.5e-34 119.2 0.1 8.9e-26 90.4 0.1 2.6 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 CDF91353.1 - 3.8e-06 26.0 0.1 0.00015 20.8 0.0 3.1 4 0 0 4 4 4 1 Kinase-like APH PF01636.18 CDF91353.1 - 0.42 10.3 0.0 0.42 10.3 0.0 2.2 3 0 0 3 3 3 0 Phosphotransferase enzyme family Metallophos PF00149.23 CDF91354.1 - 8.7e-39 132.9 2.4 1.4e-38 132.2 1.7 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ubiquitin PF00240.18 CDF91355.1 - 2.8e-06 26.6 0.3 3.3e-06 26.3 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.3 CDF91355.1 - 1.9e-05 24.2 0.1 2.1e-05 24.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 CDF91355.1 - 0.0047 17.1 0.4 0.021 15.0 0.3 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain Chorismate_bind PF00425.13 CDF91356.1 - 4.8e-70 235.8 0.0 6.7e-70 235.3 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.23 CDF91356.1 - 1.3e-31 109.5 0.0 2e-31 108.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.8 CDF91356.1 - 3.1e-11 43.4 0.0 7.5e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.8 CDF91356.1 - 2e-05 24.1 0.0 4.5e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Peptidase C26 Lipoprotein_11 PF03260.8 CDF91356.1 - 0.016 14.2 0.0 0.025 13.5 0.0 1.2 1 0 0 1 1 1 0 Lepidopteran low molecular weight (30 kD) lipoprotein PQ-loop PF04193.9 CDF91357.1 - 2.1e-21 75.2 18.6 7.2e-12 44.6 0.2 3.0 3 0 0 3 3 3 2 PQ loop repeat DUF3215 PF11503.3 CDF91358.1 - 1.6e-29 101.3 0.2 1.7e-29 101.2 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3215) PAD_M PF08527.5 CDF91358.1 - 0.078 12.3 0.0 0.093 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) middle domain CesT PF05932.8 CDF91358.1 - 0.1 12.4 0.0 0.55 10.0 0.0 1.8 2 0 0 2 2 2 0 Tir chaperone protein (CesT) family PI31_Prot_C PF08577.6 CDF91359.1 - 3.5e-11 43.5 4.3 9.1e-11 42.2 3.0 1.7 1 0 0 1 1 1 1 PI31 proteasome regulator Amidinotransf PF02274.12 CDF91359.1 - 0.076 12.0 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Amidinotransferase PAT1 PF09770.4 CDF91360.1 - 1.1e-244 814.4 22.5 1.3e-244 814.2 15.6 1.0 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Med15 PF09606.5 CDF91360.1 - 0.041 12.0 52.7 0.06 11.5 36.6 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal P34-Arc PF04045.9 CDF91361.1 - 7.1e-94 313.6 1.7 8.8e-94 313.3 1.2 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Aminotran_3 PF00202.16 CDF91363.1 - 2.9e-91 305.8 0.0 3.5e-91 305.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III FA_hydroxylase PF04116.8 CDF91364.1 - 2.1e-15 57.1 22.0 2.1e-15 57.1 15.2 2.1 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily NTP_transferase PF00483.18 CDF91365.1 - 1.1e-49 168.9 0.0 1.6e-49 168.4 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 CDF91365.1 - 3.4e-11 43.4 0.0 4.7e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.19 CDF91365.1 - 4.3e-09 35.4 6.0 2.5e-08 33.0 0.9 3.4 1 1 2 3 3 3 1 Bacterial transferase hexapeptide (six repeats) S-AdoMet_synt_N PF00438.15 CDF91365.1 - 0.038 14.2 0.1 0.096 12.9 0.0 1.7 2 0 0 2 2 2 0 S-adenosylmethionine synthetase, N-terminal domain IspD PF01128.14 CDF91365.1 - 0.077 12.5 0.0 0.44 10.0 0.0 2.1 2 0 0 2 2 2 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CTP_transf_3 PF02348.14 CDF91365.1 - 0.16 11.5 0.0 0.4 10.2 0.0 1.4 1 1 0 1 1 1 0 Cytidylyltransferase Hexapep_2 PF14602.1 CDF91365.1 - 0.17 11.5 5.7 0.14 11.6 0.4 3.1 4 0 0 4 4 4 0 Hexapeptide repeat of succinyl-transferase Ank_4 PF13637.1 CDF91366.1 - 1.2e-15 57.5 0.0 3e-07 30.7 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.1 CDF91366.1 - 1.8e-15 56.5 0.0 2e-06 27.8 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 CDF91366.1 - 2.8e-14 53.1 0.0 3.2e-07 30.5 0.0 2.9 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 CDF91366.1 - 4.9e-12 45.0 0.1 0.00021 20.9 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.1 CDF91366.1 - 5.7e-12 44.6 0.4 0.00071 19.5 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat KilA-N PF04383.8 CDF91366.1 - 5.7e-08 32.3 0.1 3.6e-07 29.7 0.1 2.4 1 1 0 1 1 1 1 KilA-N domain Y_phosphatase3 PF13350.1 CDF91367.1 - 6e-43 146.9 0.0 1.4e-42 145.6 0.0 1.7 2 0 0 2 2 2 1 Tyrosine phosphatase family Abhydrolase_5 PF12695.2 CDF91367.1 - 1e-11 44.8 0.0 2e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CDF91367.1 - 2.6e-10 40.5 0.0 4.7e-10 39.7 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Y_phosphatase3C PF13348.1 CDF91367.1 - 6.7e-08 32.5 0.7 1.5e-07 31.3 0.1 1.9 2 0 0 2 2 2 1 Tyrosine phosphatase family C-terminal region Hydrolase_4 PF12146.3 CDF91367.1 - 3.5e-05 23.5 0.0 8e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 Putative lysophospholipase Y_phosphatase2 PF03162.8 CDF91367.1 - 0.051 12.9 0.0 0.099 12.0 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family DSPc PF00782.15 CDF91367.1 - 0.059 12.9 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 CDF91367.1 - 0.092 12.7 0.0 0.34 10.9 0.0 1.8 2 0 0 2 2 2 0 Inositol hexakisphosphate Y_phosphatase PF00102.22 CDF91367.1 - 0.13 11.6 0.0 2 7.7 0.0 2.2 2 0 0 2 2 2 0 Protein-tyrosine phosphatase CRAL_TRIO PF00650.15 CDF91368.1 - 6.2e-45 152.5 0.1 1.2e-44 151.5 0.0 1.6 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 CDF91368.1 - 5.1e-13 48.9 1.4 1.7e-12 47.2 0.1 2.4 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 CDF91368.1 - 2.5e-08 33.9 0.0 4.2e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain tRNA-synt_1 PF00133.17 CDF91370.1 - 2.7e-55 187.5 0.4 1.7e-33 115.5 1.0 6.0 3 1 0 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.1 CDF91370.1 - 5.5e-44 149.6 0.0 2.2e-43 147.7 0.0 2.0 3 0 0 3 3 3 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.6 CDF91370.1 - 1.7e-28 99.4 0.1 2.2e-20 72.6 0.0 4.2 3 1 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.8 CDF91370.1 - 5.7e-07 29.4 0.1 1.3e-06 28.2 0.1 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.14 CDF91370.1 - 4e-05 22.8 0.0 0.12 11.4 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1d PF00750.14 CDF91370.1 - 6.1e-05 21.9 0.0 0.00013 20.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (R) SMC_N PF02463.14 CDF91371.1 - 2.5e-20 72.6 22.0 2e-19 69.7 15.2 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 CDF91371.1 - 1.3e-08 35.3 96.1 1.4e-08 35.3 29.2 5.4 2 2 1 3 3 2 1 AAA domain AAA_29 PF13555.1 CDF91371.1 - 0.00016 21.1 0.1 0.00039 19.8 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain WEMBL PF05701.6 CDF91371.1 - 0.0006 18.4 20.5 0.0006 18.4 14.2 3.4 2 1 1 3 3 3 2 Weak chloroplast movement under blue light AAA_21 PF13304.1 CDF91371.1 - 0.00072 19.6 0.3 0.00072 19.6 0.2 3.8 4 1 0 4 4 4 2 AAA domain Spc7 PF08317.6 CDF91371.1 - 0.0023 16.6 15.5 0.0023 16.6 10.8 6.0 3 2 3 6 6 6 3 Spc7 kinetochore protein AAA_13 PF13166.1 CDF91371.1 - 0.0045 15.5 81.1 0.66 8.3 0.0 5.0 3 2 2 5 5 5 4 AAA domain ABC_tran PF00005.22 CDF91371.1 - 0.05 13.9 0.1 0.05 13.9 0.1 5.6 3 2 0 3 3 1 0 ABC transporter Phosphodiest PF01663.17 CDF91371.1 - 0.08 12.2 0.5 0.33 10.2 0.4 2.0 1 1 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase Reo_sigmaC PF04582.7 CDF91371.1 - 0.092 11.9 21.2 0.27 10.3 1.5 4.5 2 2 3 5 5 5 0 Reovirus sigma C capsid protein DUF3584 PF12128.3 CDF91371.1 - 1.8 5.8 72.5 0.085 10.1 13.9 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3584) Uso1_p115_head PF04869.9 CDF91372.1 - 1e-102 343.0 0.5 1e-102 343.0 0.4 2.2 2 0 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.8 CDF91372.1 - 1.5e-08 34.7 37.7 1.5e-08 34.7 26.1 12.8 1 1 12 13 13 13 1 Uso1 / p115 like vesicle tethering protein, C terminal region Rad52_Rad22 PF04098.10 CDF91373.1 - 8.6e-37 126.2 0.0 1.1e-36 125.8 0.0 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein IKI3 PF04762.7 CDF91374.1 - 0 1099.6 0.2 0 1099.6 0.1 1.6 1 1 1 2 2 2 1 IKI3 family TPR_1 PF00515.23 CDF91374.1 - 0.11 12.1 4.8 0.1 12.2 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.12 CDF91374.1 - 0.2 11.6 6.0 0.27 11.2 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.1 CDF91374.1 - 1 9.2 6.6 0.78 9.6 0.4 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat Vac14_Fig4_bd PF11916.3 CDF91376.1 - 5.4e-72 240.7 5.6 1.3e-71 239.5 3.9 1.7 1 0 0 1 1 1 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.2 CDF91376.1 - 9.1e-49 163.8 1.8 7.6e-39 132.0 0.0 4.7 5 0 0 5 5 5 2 Vacuolar 14 Fab1-binding region HEAT PF02985.17 CDF91376.1 - 2e-11 42.9 9.7 0.00024 20.9 0.0 7.9 8 0 0 8 8 8 2 HEAT repeat CLASP_N PF12348.3 CDF91376.1 - 4.6e-09 35.9 0.8 0.005 16.2 0.1 4.6 3 1 1 4 4 4 3 CLASP N terminal HEAT_2 PF13646.1 CDF91376.1 - 2.7e-07 30.7 5.7 0.0035 17.5 0.0 5.5 6 1 0 6 6 6 1 HEAT repeats HEAT_EZ PF13513.1 CDF91376.1 - 3.3e-07 30.6 6.1 0.075 13.5 0.0 6.2 6 2 1 7 7 7 2 HEAT-like repeat Cnd1 PF12717.2 CDF91376.1 - 6.2e-07 29.4 9.7 0.018 14.9 0.4 4.4 5 0 0 5 5 5 3 non-SMC mitotic condensation complex subunit 1 Arm PF00514.18 CDF91376.1 - 0.021 14.6 6.9 3.5 7.5 0.0 4.9 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Sigma70_r2 PF04542.9 CDF91376.1 - 0.089 12.4 0.1 4.7 6.9 0.2 2.5 2 0 0 2 2 2 0 Sigma-70 region 2 RasGEF_N_2 PF14663.1 CDF91376.1 - 0.3 11.0 5.0 0.73 9.7 0.1 3.5 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain zf-C2H2_2 PF12756.2 CDF91377.1 - 4e-32 110.3 7.6 9.9e-30 102.6 2.6 2.5 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.7 CDF91377.1 - 0.0079 15.9 4.4 0.35 10.6 0.6 2.6 2 0 0 2 2 2 2 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_jaz PF12171.3 CDF91377.1 - 8.7 6.6 21.6 0.32 11.1 0.9 4.2 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding DUF663 PF04950.7 CDF91378.1 - 2.8e-95 318.7 0.0 4.9e-95 317.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF663) AARP2CN PF08142.7 CDF91378.1 - 3e-23 81.1 0.0 8e-23 79.7 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain Ribosomal_S14 PF00253.16 CDF91379.1 - 7.2e-19 66.9 4.1 7.9e-19 66.7 2.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DUF4428 PF14471.1 CDF91379.1 - 0.15 11.8 0.5 0.18 11.6 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) RNA_POL_M_15KD PF02150.11 CDF91379.1 - 0.19 11.4 1.2 6.6 6.5 0.1 2.1 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit Prim_Zn_Ribbon PF08273.7 CDF91379.1 - 0.26 11.3 2.1 5.5 7.1 0.2 2.1 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase Peptidase_M16 PF00675.15 CDF91380.1 - 2.4e-38 131.1 0.0 8.4e-38 129.4 0.0 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.16 CDF91380.1 - 2.1e-29 102.4 0.2 6e-17 61.9 0.0 2.6 2 0 0 2 2 2 2 Peptidase M16 inactive domain zf-AD PF07776.10 CDF91382.1 - 0.1 12.6 0.5 0.46 10.5 0.0 2.3 2 1 1 3 3 3 0 Zinc-finger associated domain (zf-AD) Pex19 PF04614.7 CDF91383.1 - 7.8e-56 189.4 10.2 7.8e-56 189.4 7.1 1.6 1 1 1 2 2 2 1 Pex19 protein family IL34 PF15036.1 CDF91383.1 - 0.0055 16.2 0.5 0.016 14.8 0.2 1.8 1 1 0 1 1 1 1 Interleukin 34 XPC-binding PF09280.6 CDF91383.1 - 0.024 14.0 2.7 0.035 13.5 0.0 2.7 3 0 0 3 3 3 0 XPC-binding domain GAT PF03127.9 CDF91383.1 - 0.13 12.2 5.3 1.7 8.6 0.4 2.9 2 1 0 2 2 2 0 GAT domain Herpes_UL17 PF04559.7 CDF91383.1 - 0.26 9.8 1.3 0.33 9.4 0.9 1.1 1 0 0 1 1 1 0 Herpesvirus UL17 protein GET2 PF08690.5 CDF91383.1 - 0.76 8.9 17.4 9.9 5.2 0.3 3.0 1 1 2 3 3 3 0 GET complex subunit GET2 HSCB_C PF07743.8 CDF91383.1 - 1.3 9.5 7.4 0.54 10.7 1.2 2.9 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain FadA PF09403.5 CDF91383.1 - 1.9 8.5 9.9 0.72 9.8 3.6 2.3 2 0 0 2 2 2 0 Adhesion protein FadA ING PF12998.2 CDF91383.1 - 8.7 6.6 11.0 0.76 10.0 1.3 3.3 3 1 0 4 4 4 0 Inhibitor of growth proteins N-terminal histone-binding CFEM PF05730.6 CDF91384.1 - 2.4e-08 33.6 13.3 6.9e-08 32.1 9.2 1.8 1 0 0 1 1 1 1 CFEM domain FAM196 PF15265.1 CDF91384.1 - 0.71 9.0 18.5 0.79 8.8 12.8 1.1 1 0 0 1 1 1 0 FAM196 family TFIIA PF03153.8 CDF91384.1 - 2.9 7.7 12.1 3.4 7.4 8.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Arrestin_N PF00339.24 CDF91385.1 - 1.4e-05 24.9 0.1 0.00012 21.9 0.0 2.1 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain ATP-synt_10 PF05176.9 CDF91386.1 - 6.9e-81 271.2 0.0 8.5e-81 270.9 0.0 1.0 1 0 0 1 1 1 1 ATP10 protein Iso_dh PF00180.15 CDF91387.1 - 2.4e-66 224.0 0.0 2.8e-66 223.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase COX7C PF02935.11 CDF91388.1 - 5.7e-19 67.6 1.4 6.1e-19 67.5 1.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc FSH1 PF03959.8 CDF91389.1 - 0.023 14.1 0.0 0.023 14.1 0.0 1.1 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Sec1 PF00995.18 CDF91390.1 - 7.3e-69 232.8 1.3 9e-69 232.5 0.9 1.0 1 0 0 1 1 1 1 Sec1 family AAA PF00004.24 CDF91391.1 - 2.9e-90 299.2 0.0 9.9e-44 148.7 0.0 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 CDF91391.1 - 6.1e-13 48.3 0.0 2.6e-05 23.3 0.0 3.2 3 1 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 CDF91391.1 - 3.9e-12 46.5 0.1 0.00013 22.0 0.0 3.2 2 1 1 3 3 3 2 AAA ATPase domain AAA_2 PF07724.9 CDF91391.1 - 3.5e-11 43.3 0.0 0.00024 21.0 0.0 2.8 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.9 CDF91391.1 - 5.2e-11 42.4 0.1 6.9e-05 22.5 0.0 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 CDF91391.1 - 2.4e-10 40.6 0.5 7.3e-05 22.9 0.0 4.3 2 2 0 2 2 2 2 AAA domain AAA_14 PF13173.1 CDF91391.1 - 2.7e-09 37.0 0.0 0.00013 21.8 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_33 PF13671.1 CDF91391.1 - 2.5e-07 30.6 0.0 0.00018 21.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.8 CDF91391.1 - 1.2e-06 27.5 0.0 0.0045 15.7 0.0 2.4 2 0 0 2 2 2 2 TIP49 C-terminus CDC48_N PF02359.13 CDF91391.1 - 8.1e-06 25.6 0.1 2.2e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_17 PF13207.1 CDF91391.1 - 9.2e-06 26.4 0.0 0.083 13.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 CDF91391.1 - 1.8e-05 24.8 0.0 0.37 10.9 0.0 2.8 2 0 0 2 2 2 2 RNA helicase Bac_DnaA PF00308.13 CDF91391.1 - 1.9e-05 24.4 0.0 0.00033 20.3 0.0 2.5 2 0 0 2 2 2 1 Bacterial dnaA protein Sigma54_activ_2 PF14532.1 CDF91391.1 - 2.2e-05 24.5 0.0 0.15 12.1 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain Mg_chelatase PF01078.16 CDF91391.1 - 2.9e-05 23.3 0.2 0.092 11.8 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 CDF91391.1 - 3.4e-05 23.5 3.5 0.0039 16.8 0.2 3.5 4 0 0 4 4 2 1 Part of AAA domain AAA_28 PF13521.1 CDF91391.1 - 3.6e-05 23.7 0.0 0.11 12.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 CDF91391.1 - 4.6e-05 22.9 5.6 0.27 10.5 0.0 4.0 2 2 1 3 3 3 2 AAA domain Zeta_toxin PF06414.7 CDF91391.1 - 6.3e-05 22.1 0.0 0.2 10.7 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin NACHT PF05729.7 CDF91391.1 - 0.00073 19.2 0.2 0.046 13.3 0.0 3.4 4 0 0 4 4 4 1 NACHT domain AAA_3 PF07726.6 CDF91391.1 - 0.00096 18.7 0.0 1.2 8.7 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 CDF91391.1 - 0.0011 17.7 0.0 0.038 12.6 0.0 2.4 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein Arch_ATPase PF01637.13 CDF91391.1 - 0.0012 18.6 0.0 1.7 8.2 0.0 3.4 2 2 2 4 4 4 1 Archaeal ATPase IstB_IS21 PF01695.12 CDF91391.1 - 0.0012 18.2 0.0 1.6 8.1 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein ABC_tran PF00005.22 CDF91391.1 - 0.0025 18.1 0.0 0.13 12.5 0.0 2.8 2 1 0 2 2 2 1 ABC transporter Viral_helicase1 PF01443.13 CDF91391.1 - 0.0042 16.6 0.0 0.034 13.6 0.0 2.2 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.1 CDF91391.1 - 0.0047 16.5 0.1 0.45 10.0 0.1 2.7 1 1 0 2 2 2 1 AAA domain Sigma54_activat PF00158.21 CDF91391.1 - 0.014 14.8 0.0 4.3 6.7 0.0 3.3 2 2 0 2 2 2 0 Sigma-54 interaction domain DUF815 PF05673.8 CDF91391.1 - 0.016 14.1 0.0 0.66 8.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_24 PF13479.1 CDF91391.1 - 0.019 14.5 0.1 4.2 6.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.1 CDF91391.1 - 0.032 13.7 0.1 0.19 11.3 0.0 2.3 2 1 0 2 2 2 0 AAA domain UPF0079 PF02367.12 CDF91391.1 - 0.04 13.5 0.2 2.4 7.8 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AFG1_ATPase PF03969.11 CDF91391.1 - 0.089 11.5 0.0 0.24 10.1 0.0 1.6 1 0 0 1 1 1 0 AFG1-like ATPase AAA_18 PF13238.1 CDF91391.1 - 0.095 13.0 0.0 3.9 7.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain KaiC PF06745.8 CDF91391.1 - 0.22 10.5 4.1 14 4.7 0.1 3.6 3 1 1 4 4 4 0 KaiC Ribonucleas_3_3 PF14622.1 CDF91392.1 - 0.00055 19.8 0.3 0.0013 18.6 0.0 1.7 2 1 0 2 2 2 1 Ribonuclease-III-like DSHCT PF08148.7 CDF91393.1 - 6e-58 195.0 0.3 1.2e-57 194.0 0.2 1.5 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.24 CDF91393.1 - 1.2e-21 76.9 0.0 1.2e-21 76.9 0.0 2.3 3 0 0 3 3 3 1 DEAD/DEAH box helicase rRNA_proc-arch PF13234.1 CDF91393.1 - 2.8e-08 33.2 0.7 5.1e-08 32.4 0.5 1.4 1 0 0 1 1 1 1 rRNA-processing arch domain Helicase_C PF00271.26 CDF91393.1 - 4.5e-08 32.8 0.0 2e-07 30.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDF91393.1 - 0.0037 17.1 1.8 0.012 15.4 0.1 2.7 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Bromodomain PF00439.20 CDF91394.1 - 2.7e-41 139.3 0.1 4.1e-20 71.4 0.0 2.8 3 0 0 3 3 3 2 Bromodomain Bap31 PF05529.7 CDF91395.1 - 3.7e-50 170.0 5.0 4.3e-50 169.8 3.5 1.0 1 0 0 1 1 1 1 B-cell receptor-associated protein 31-like DUF2383 PF09537.5 CDF91395.1 - 0.026 14.7 1.8 0.037 14.2 1.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) DUF724 PF05266.9 CDF91395.1 - 0.037 13.6 1.7 0.055 13.0 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) ADIP PF11559.3 CDF91395.1 - 0.045 13.6 6.0 0.75 9.6 4.1 2.1 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding DivIC PF04977.10 CDF91395.1 - 0.07 12.6 8.8 0.88 9.1 4.1 2.9 2 1 1 3 3 3 0 Septum formation initiator FlxA PF14282.1 CDF91395.1 - 0.11 12.4 1.6 0.18 11.7 1.1 1.3 1 0 0 1 1 1 0 FlxA-like protein IFT20 PF14931.1 CDF91395.1 - 0.87 9.4 5.7 0.65 9.8 2.7 1.6 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 Dus PF01207.12 CDF91396.1 - 6.3e-43 146.7 0.0 5.6e-42 143.6 0.0 2.0 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) zf-CCCH PF00642.19 CDF91396.1 - 0.00011 21.8 8.7 0.0058 16.2 0.2 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C2H2_4 PF13894.1 CDF91397.1 - 4.9e-05 23.3 12.1 0.053 13.8 0.3 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 CDF91397.1 - 0.00039 20.4 5.1 0.14 12.3 0.0 3.0 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 CDF91397.1 - 0.0015 18.7 17.1 0.067 13.5 0.7 3.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type Nucleoplasmin PF03066.10 CDF91397.1 - 0.0019 17.7 1.7 0.0041 16.6 1.2 1.6 1 0 0 1 1 1 1 Nucleoplasmin zf-H2C2_2 PF13465.1 CDF91397.1 - 0.043 14.1 1.1 0.043 14.1 0.8 3.6 3 0 0 3 3 3 0 Zinc-finger double domain CENP-B_dimeris PF09026.5 CDF91397.1 - 0.11 12.8 9.6 0.44 10.7 6.7 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF1765 PF08578.5 CDF91399.1 - 1.5e-22 79.9 5.5 1.5e-22 79.9 3.8 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1765) Oxidored_q5_N PF01059.12 CDF91399.1 - 0.06 13.2 3.5 0.25 11.2 2.4 2.1 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase chain 4, amino terminus BRE1 PF08647.6 CDF91400.1 - 1.2e-29 102.0 14.6 1.2e-29 102.0 10.1 5.5 5 1 2 7 7 6 1 BRE1 E3 ubiquitin ligase zf-C3HC4_2 PF13923.1 CDF91400.1 - 6.9e-07 29.1 14.2 1.4e-06 28.1 9.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CDF91400.1 - 1.4e-06 27.8 11.5 2.7e-06 26.9 8.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDF91400.1 - 1e-05 25.1 13.9 2.4e-05 23.9 9.6 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.20 CDF91400.1 - 5.5e-05 22.7 14.5 0.00013 21.5 10.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.1 CDF91400.1 - 0.00026 20.7 11.3 0.00062 19.5 7.8 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C2H2 PF00096.21 CDF91400.1 - 0.0055 16.9 0.3 0.0055 16.9 0.2 2.9 3 0 0 3 3 3 1 Zinc finger, C2H2 type Prok-RING_4 PF14447.1 CDF91400.1 - 0.0074 15.8 4.5 0.019 14.4 3.1 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.1 CDF91400.1 - 0.018 14.8 4.7 0.039 13.7 3.2 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.1 CDF91400.1 - 0.04 13.6 8.8 0.19 11.5 6.1 2.3 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_4 PF14570.1 CDF91400.1 - 3.8 7.1 11.2 9.3 5.9 7.7 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.1 CDF91400.1 - 5 7.0 11.1 12 5.8 7.7 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C2H2_4 PF13894.1 CDF91400.1 - 9.4 6.8 8.0 1 9.8 0.1 2.9 2 1 0 2 2 2 0 C2H2-type zinc finger Dus PF01207.12 CDF91401.1 - 4.3e-79 265.5 0.0 5.1e-79 265.3 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Ribosomal_L31e PF01198.14 CDF91402.1 - 5.5e-30 102.8 1.2 6.6e-30 102.6 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e Rxt3 PF08642.5 CDF91403.1 - 1.9e-28 98.9 0.0 5.8e-28 97.4 0.0 1.8 3 0 0 3 3 3 1 Histone deacetylation protein Rxt3 DUF4050 PF13259.1 CDF91404.1 - 3.9e-19 68.7 0.9 5.9e-19 68.1 0.6 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF4050) GCN5L1 PF06320.8 CDF91405.1 - 5.4e-05 22.9 0.1 9.9e-05 22.1 0.0 1.4 1 1 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) Vps39_1 PF10366.4 CDF91406.1 - 4e-25 87.9 0.8 4e-25 87.9 0.6 2.7 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.4 CDF91406.1 - 7.7e-17 61.4 0.2 1.7e-16 60.3 0.1 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 DUF3768 PF12599.3 CDF91406.1 - 0.065 13.1 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3768) Utp21 PF04192.7 CDF91407.1 - 1.9e-72 243.2 0.0 2.7e-72 242.6 0.0 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.27 CDF91407.1 - 1.3e-20 72.3 10.5 7.2e-10 38.3 0.2 7.1 6 1 0 6 6 6 3 WD domain, G-beta repeat PQQ_2 PF13360.1 CDF91407.1 - 9.3e-06 25.2 0.1 0.0045 16.4 0.0 3.6 2 1 0 2 2 2 1 PQQ-like domain Cytochrom_D1 PF02239.11 CDF91407.1 - 5.4e-05 21.6 0.0 0.0011 17.2 0.0 2.2 2 0 0 2 2 2 1 Cytochrome D1 heme domain eIF2A PF08662.6 CDF91407.1 - 7.4e-05 22.5 0.1 0.011 15.4 0.0 3.2 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.6 CDF91407.1 - 0.0022 16.8 0.1 0.12 11.1 0.0 2.8 2 1 0 2 2 2 1 Nup133 N terminal like CPSF_A PF03178.10 CDF91407.1 - 0.0024 17.0 0.0 0.052 12.6 0.0 2.8 3 0 0 3 3 3 1 CPSF A subunit region Apc4_WD40 PF12894.2 CDF91407.1 - 0.0068 15.8 0.0 1.6 8.2 0.0 3.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain His_Phos_2 PF00328.17 CDF91408.1 - 2.3e-127 425.1 0.1 3.4e-127 424.5 0.1 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) RimK PF08443.6 CDF91408.1 - 4e-10 39.4 0.0 8.4e-10 38.4 0.0 1.5 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.9 CDF91408.1 - 0.01 15.7 0.4 0.044 13.6 0.2 2.1 2 1 0 2 2 2 0 ATP-grasp domain Ctr PF04145.10 CDF91409.1 - 1.9e-37 128.4 1.7 3.8e-37 127.5 1.2 1.5 1 1 0 1 1 1 1 Ctr copper transporter family DUF443 PF04276.7 CDF91409.1 - 0.029 13.7 0.4 0.063 12.6 0.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF443) Pribosyl_synth PF14572.1 CDF91410.1 - 9e-40 136.3 2.4 5.7e-31 107.6 0.4 2.3 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.1 CDF91410.1 - 8.4e-39 131.9 0.1 8.6e-38 128.6 0.0 2.3 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.22 CDF91410.1 - 5.4e-07 29.3 0.2 1.2e-05 25.0 0.1 2.3 1 1 0 1 1 1 1 Phosphoribosyl transferase domain SRR1 PF07985.7 CDF91411.1 - 4.9e-15 55.1 0.0 1e-14 54.2 0.0 1.5 1 0 0 1 1 1 1 SRR1 Acyl_transf_1 PF00698.16 CDF91412.1 - 7.1e-94 314.7 0.0 1.5e-92 310.3 0.0 2.7 3 0 0 3 3 3 1 Acyl transferase domain MaoC_dehydratas PF01575.14 CDF91412.1 - 5.5e-38 129.1 0.0 1e-37 128.2 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain DUF1729 PF08354.5 CDF91412.1 - 1.3e-30 104.9 0.1 3e-30 103.7 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) MaoC_dehydrat_N PF13452.1 CDF91412.1 - 2.7e-13 49.8 0.0 8.9e-13 48.1 0.0 2.0 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase NMO PF03060.10 CDF91412.1 - 0.0025 17.0 0.1 0.016 14.3 0.1 2.3 1 1 0 1 1 1 1 Nitronate monooxygenase Lipase_3 PF01764.20 CDF91412.1 - 0.073 12.6 0.4 2.6 7.6 0.0 2.6 2 0 0 2 2 2 0 Lipase (class 3) Voldacs PF03517.8 CDF91413.1 - 5.1e-15 55.5 0.0 7e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling Orn_Arg_deC_N PF02784.11 CDF91414.1 - 7.5e-78 261.1 0.0 1.1e-77 260.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.17 CDF91414.1 - 7.3e-30 103.0 0.1 1.2e-29 102.3 0.1 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain eIF3_N PF09440.5 CDF91414.1 - 0.11 12.6 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 eIF3 subunit 6 N terminal domain GATA PF00320.22 CDF91415.1 - 3.1e-10 39.2 9.3 3.1e-10 39.2 6.4 2.1 2 0 0 2 2 2 1 GATA zinc finger Mtr2 PF10429.4 CDF91416.1 - 1.5e-68 229.7 0.1 1.7e-68 229.5 0.1 1.0 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 NTF2 PF02136.15 CDF91416.1 - 0.043 14.1 0.0 0.076 13.3 0.0 1.4 1 0 0 1 1 1 0 Nuclear transport factor 2 (NTF2) domain Toxin_ToxA PF11584.3 CDF91416.1 - 0.097 12.5 0.1 0.19 11.5 0.0 1.5 2 0 0 2 2 2 0 Proteinaceous host-selective toxin ToxA SUR7 PF06687.7 CDF91417.1 - 3.1e-38 131.4 17.0 3.7e-38 131.2 11.8 1.0 1 0 0 1 1 1 1 SUR7/PalI family ABC_membrane_2 PF06472.10 CDF91418.1 - 1.9e-73 247.0 6.4 2.7e-73 246.5 4.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.22 CDF91418.1 - 2.9e-17 63.2 0.0 6.6e-17 62.0 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 CDF91418.1 - 3.5e-05 23.9 5.1 0.00013 22.0 0.3 2.9 3 1 0 3 3 3 1 AAA domain AAA_23 PF13476.1 CDF91418.1 - 0.0045 17.3 1.1 0.014 15.7 0.1 2.3 2 0 0 2 2 2 1 AAA domain DUF258 PF03193.11 CDF91418.1 - 0.0078 15.4 0.0 0.072 12.2 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_29 PF13555.1 CDF91418.1 - 0.019 14.4 0.0 0.044 13.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.14 CDF91418.1 - 0.036 13.2 0.0 0.15 11.3 0.0 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_16 PF13191.1 CDF91418.1 - 0.095 12.6 0.1 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain EAP30 PF04157.11 CDF91419.1 - 6.6e-40 136.6 0.1 1.1e-39 135.9 0.1 1.3 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.3 CDF91419.1 - 9.2e-31 105.5 0.2 2.3e-30 104.2 0.1 1.7 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 GRAM PF02893.15 CDF91419.1 - 0.016 14.7 0.0 0.086 12.3 0.0 2.2 2 0 0 2 2 2 0 GRAM domain TFIIH_BTF_p62_N PF08567.6 CDF91419.1 - 0.047 13.3 0.0 0.42 10.2 0.0 2.2 2 0 0 2 2 2 0 TFIIH p62 subunit, N-terminal domain Nudix_N_2 PF14803.1 CDF91419.1 - 0.33 10.6 0.1 0.33 10.6 0.0 2.8 3 0 0 3 3 3 0 Nudix N-terminal Rubredoxin PF00301.15 CDF91419.1 - 3 7.8 12.5 0.28 11.0 0.1 3.5 4 0 0 4 4 4 0 Rubredoxin gp32 PF08804.5 CDF91419.1 - 4.9 7.3 5.5 6.4 6.9 0.3 2.5 2 0 0 2 2 2 0 gp32 DNA binding protein like DZR PF12773.2 CDF91419.1 - 7.3 6.4 12.2 1.7 8.4 1.7 2.8 2 1 0 2 2 2 0 Double zinc ribbon Mo25 PF08569.6 CDF91420.1 - 4.6e-116 387.5 11.6 5.3e-116 387.3 8.0 1.0 1 0 0 1 1 1 1 Mo25-like DUF3361 PF11841.3 CDF91420.1 - 0.0012 18.5 2.4 0.0024 17.5 1.6 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) DUF1436 PF07262.6 CDF91420.1 - 0.0047 16.4 1.0 0.0064 15.9 0.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1436) DUF3479 PF11965.3 CDF91420.1 - 0.033 13.9 0.1 14 5.4 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF3479) CDC73 PF05179.9 CDF91421.1 - 7.9e-69 232.0 1.9 1.8e-68 230.8 1.3 1.6 1 1 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family DUF2220 PF09983.4 CDF91421.1 - 0.088 11.9 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria C-term(DUF2220) OB_NTP_bind PF07717.11 CDF91422.1 - 7.3e-21 74.1 0.0 2.5e-20 72.3 0.0 2.0 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold RWD PF05773.17 CDF91422.1 - 9.9e-13 47.9 2.9 1.2e-12 47.7 0.7 2.2 2 0 0 2 2 2 1 RWD domain Helicase_C PF00271.26 CDF91422.1 - 7.6e-10 38.5 0.2 1.8e-09 37.3 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 CDF91422.1 - 4.5e-09 36.0 2.1 8.7e-09 35.0 0.6 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase HA2 PF04408.18 CDF91422.1 - 2e-08 34.1 0.0 2e-08 34.1 0.0 2.5 3 0 0 3 3 2 1 Helicase associated domain (HA2) AAA_29 PF13555.1 CDF91422.1 - 0.00027 20.3 0.0 0.00066 19.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain T2SE PF00437.15 CDF91422.1 - 0.00052 18.9 0.1 0.0013 17.7 0.1 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.1 CDF91422.1 - 0.0015 18.6 0.1 0.0053 16.8 0.1 1.9 1 0 0 1 1 1 1 AAA domain KaiC PF06745.8 CDF91422.1 - 0.0018 17.4 0.1 0.018 14.1 0.0 2.6 3 0 0 3 3 3 1 KaiC AAA_25 PF13481.1 CDF91422.1 - 0.0034 16.7 0.0 0.008 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain Zot PF05707.7 CDF91422.1 - 0.0049 16.3 0.0 0.019 14.4 0.0 2.1 1 1 0 1 1 1 1 Zonular occludens toxin (Zot) AAA_19 PF13245.1 CDF91422.1 - 0.0055 16.4 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_23 PF13476.1 CDF91422.1 - 0.0063 16.8 0.1 0.0063 16.8 0.1 4.5 2 1 1 4 4 2 1 AAA domain PFU PF09070.6 CDF91422.1 - 0.0088 16.0 0.1 0.041 13.8 0.0 2.2 2 0 0 2 2 1 1 PFU (PLAA family ubiquitin binding) FtsK_SpoIIIE PF01580.13 CDF91422.1 - 0.011 15.2 0.0 0.027 13.9 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family PhoH PF02562.11 CDF91422.1 - 0.012 14.8 0.0 0.045 12.9 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_16 PF13191.1 CDF91422.1 - 0.036 14.0 0.0 0.15 12.0 0.0 2.2 1 0 0 1 1 1 0 AAA ATPase domain Glyco_hydro_32N PF00251.15 CDF91423.1 - 9.3e-84 281.3 6.4 1.6e-83 280.6 4.4 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.7 CDF91423.1 - 1.4e-08 34.9 0.1 3.1e-08 33.8 0.1 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal MFS_1 PF07690.11 CDF91424.1 - 3.9e-27 94.8 19.7 3.9e-27 94.8 13.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily EF-hand_1 PF00036.27 CDF91425.1 - 1.3e-23 80.4 13.5 3.1e-05 22.9 0.7 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.1 CDF91425.1 - 1.4e-18 65.0 6.3 0.00024 20.7 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.1 CDF91425.1 - 7.2e-18 64.4 7.4 1.2e-09 38.1 1.7 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.1 CDF91425.1 - 2.4e-14 51.8 18.9 0.0012 18.0 0.2 4.6 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.1 CDF91425.1 - 4.1e-11 42.3 15.8 0.0026 17.3 0.1 4.5 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_4 PF12763.2 CDF91425.1 - 3.9e-06 26.5 11.0 0.021 14.5 0.3 4.0 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.4 CDF91425.1 - 7.7e-05 22.6 0.0 0.048 13.6 0.0 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.1 CDF91425.1 - 0.00011 21.9 0.0 0.91 9.4 0.0 3.2 2 1 1 3 3 3 2 EF-hand domain Diphthamide_syn PF01866.12 CDF91426.1 - 2.8e-45 154.9 0.0 3e-22 79.2 0.1 2.2 2 0 0 2 2 2 2 Putative diphthamide synthesis protein Amidohydro_4 PF13147.1 CDF91427.1 - 1e-07 32.2 0.0 1.3e-07 31.9 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_2 PF04909.9 CDF91427.1 - 3.5e-07 30.0 0.0 7e-07 29.0 0.0 1.6 1 1 0 1 1 1 1 Amidohydrolase Proteasom_Rpn13 PF04683.8 CDF91428.1 - 6.5e-23 80.6 0.0 8.9e-23 80.1 0.0 1.2 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor CinA PF02464.12 CDF91429.1 - 3.3e-32 111.0 0.0 3.9e-32 110.8 0.0 1.0 1 0 0 1 1 1 1 Competence-damaged protein Ded_cyto PF06920.8 CDF91430.1 - 2.4e-20 72.5 0.0 5.9e-20 71.3 0.0 1.6 1 0 0 1 1 1 1 Dedicator of cytokinesis PP-binding PF00550.20 CDF91431.1 - 9.3e-09 35.4 0.2 1.3e-08 34.9 0.1 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.1 CDF91431.1 - 6.8e-06 26.0 1.9 1.1e-05 25.3 1.3 1.4 1 1 0 1 1 1 1 Acyl-carrier DUF1493 PF07377.7 CDF91431.1 - 0.0025 17.8 0.2 0.0037 17.3 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1493) LRR_4 PF12799.2 CDF91432.1 - 7.6e-38 127.5 49.0 9.1e-10 37.9 4.1 7.2 2 2 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CDF91432.1 - 3.4e-24 84.3 67.9 9.1e-09 34.9 3.2 5.9 2 2 6 8 8 8 6 Leucine rich repeat LRR_1 PF00560.28 CDF91432.1 - 7.6e-11 40.4 43.8 0.017 15.0 0.4 11.1 11 0 0 11 11 11 5 Leucine Rich Repeat LRR_6 PF13516.1 CDF91432.1 - 6.8e-10 37.9 33.0 0.22 11.7 0.1 10.6 7 3 4 11 11 11 4 Leucine Rich repeat LRR_7 PF13504.1 CDF91432.1 - 1.2e-09 36.7 18.8 0.19 12.0 0.1 9.6 8 2 0 8 8 8 3 Leucine rich repeat LRR_9 PF14580.1 CDF91432.1 - 6.6e-08 32.3 17.3 0.00016 21.2 2.7 4.0 1 1 3 4 4 4 3 Leucine-rich repeat Methyltransf_12 PF08242.7 CDF91432.1 - 0.28 11.6 2.4 2.8 8.4 0.7 2.3 2 0 0 2 2 2 0 Methyltransferase domain DUF3744 PF12558.3 CDF91432.1 - 3.1 8.2 14.7 6.3 7.3 2.7 4.0 2 2 1 3 3 3 0 ATP-binding cassette cobalt transporter EamA PF00892.15 CDF91433.1 - 7.4e-27 93.8 30.5 4.6e-15 55.7 5.2 2.6 2 1 0 2 2 2 2 EamA-like transporter family EmrE PF13536.1 CDF91433.1 - 1.8e-07 31.3 7.7 1.8e-07 31.3 5.3 4.1 3 1 2 5 5 5 2 Multidrug resistance efflux transporter UAA PF08449.6 CDF91433.1 - 0.035 13.0 14.5 0.28 10.0 1.4 2.3 1 1 1 2 2 2 0 UAA transporter family Zip PF02535.17 CDF91433.1 - 7.5 5.4 11.8 0.052 12.5 1.8 2.2 3 0 0 3 3 3 0 ZIP Zinc transporter tRNA-synt_2b PF00587.20 CDF91434.1 - 4.5e-49 166.3 0.0 7.8e-49 165.5 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 CDF91434.1 - 1.7e-16 59.8 0.0 3e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 Anticodon binding domain APG17 PF04108.7 CDF91435.1 - 7e-102 341.2 17.2 7.9e-102 341.1 11.9 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 Med30 PF11315.3 CDF91435.1 - 0.0097 16.0 4.2 0.022 14.8 0.8 3.1 2 1 0 2 2 2 1 Mediator complex subunit 30 MbeD_MobD PF04899.7 CDF91435.1 - 0.065 13.1 1.2 0.27 11.1 0.1 2.7 3 0 0 3 3 3 0 MbeD/MobD like Synaptonemal_3 PF15191.1 CDF91435.1 - 0.1 12.3 1.4 0.61 9.8 0.0 2.9 3 0 0 3 3 3 0 Synaptonemal complex central element protein 3 DUF4294 PF14127.1 CDF91435.1 - 0.1 12.1 0.2 0.1 12.1 0.1 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4294) NPV_P10 PF05531.7 CDF91435.1 - 0.28 11.4 5.6 11 6.3 0.4 3.8 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein MRP-S26 PF14943.1 CDF91435.1 - 5.4 6.5 10.4 3.2 7.2 0.1 3.2 3 0 0 3 3 3 0 Mitochondrial ribosome subunit S26 DUF2203 PF09969.4 CDF91435.1 - 9.6 6.4 11.3 2.1 8.5 0.1 4.0 2 1 2 4 4 4 0 Uncharacterized conserved protein (DUF2203) G-patch PF01585.18 CDF91436.1 - 3.3e-14 52.3 2.0 5.8e-14 51.6 1.4 1.4 1 0 0 1 1 1 1 G-patch domain GCFC PF07842.7 CDF91436.1 - 1.6e-08 34.2 0.9 2.9e-08 33.4 0.6 1.3 1 0 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein G-patch_2 PF12656.2 CDF91436.1 - 1.6e-06 27.8 0.4 3.1e-06 26.9 0.3 1.4 1 0 0 1 1 1 1 DExH-box splicing factor binding site DUF2205 PF10224.4 CDF91436.1 - 0.093 12.3 2.4 0.41 10.2 1.7 2.1 1 0 0 1 1 1 0 Predicted coiled-coil protein (DUF2205) CHCH PF06747.8 CDF91437.1 - 3e-07 30.1 4.5 7.1e-07 28.9 3.1 1.7 1 0 0 1 1 1 1 CHCH domain GCK PF07802.6 CDF91437.1 - 0.06 13.4 2.6 0.28 11.3 1.8 2.2 1 0 0 1 1 1 0 GCK domain Synaptobrevin PF00957.16 CDF91438.1 - 4.2e-15 55.1 1.4 7.1e-15 54.3 0.9 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.1 CDF91438.1 - 5.2e-15 54.7 0.0 8.6e-15 54.0 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain UPF0449 PF15136.1 CDF91438.1 - 0.025 14.7 0.2 0.042 14.0 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 Tbf5 PF06331.7 CDF91438.1 - 0.078 12.7 0.4 0.12 12.1 0.3 1.3 1 0 0 1 1 1 0 Transcription factor TFIIH complex subunit Tfb5 FMN_dh PF01070.13 CDF91439.1 - 1.8e-118 395.5 0.8 1.9e-118 395.4 0.0 1.4 2 0 0 2 2 2 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.23 CDF91439.1 - 1.6e-22 79.0 0.0 5.1e-22 77.4 0.0 1.9 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.12 CDF91439.1 - 3.6e-05 22.8 0.0 0.00011 21.2 0.0 1.6 1 1 0 2 2 2 1 Conserved region in glutamate synthase IMPDH PF00478.20 CDF91439.1 - 0.00026 19.9 0.3 0.0034 16.3 0.0 2.6 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.10 CDF91439.1 - 0.0029 16.7 0.0 0.0065 15.6 0.0 1.5 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.16 CDF91439.1 - 0.025 13.8 0.3 4.9 6.3 0.0 2.4 1 1 0 2 2 2 0 Histidine biosynthesis protein ThiG PF05690.9 CDF91439.1 - 0.035 13.1 5.0 0.55 9.2 0.0 2.8 3 0 0 3 3 3 0 Thiazole biosynthesis protein ThiG CNH PF00780.17 CDF91440.1 - 4.9e-17 62.2 1.5 1.5e-16 60.6 1.0 1.8 1 1 0 1 1 1 1 CNH domain PH PF00169.24 CDF91440.1 - 7e-09 35.8 8.0 5.8e-07 29.6 0.1 3.8 3 1 0 3 3 3 2 PH domain RhoGEF PF00621.15 CDF91440.1 - 3.8e-06 26.8 1.9 1.6e-05 24.8 0.0 2.7 3 0 0 3 3 3 1 RhoGEF domain PH_5 PF15405.1 CDF91440.1 - 1.1e-05 25.4 0.1 6.1e-05 22.9 0.1 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain adh_short PF00106.20 CDF91441.1 - 2.2e-20 73.2 0.0 4.6e-20 72.1 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CDF91441.1 - 2.4e-07 30.5 0.0 1.7e-06 27.8 0.0 2.0 1 1 0 1 1 1 1 KR domain 3Beta_HSD PF01073.14 CDF91441.1 - 0.025 13.2 0.0 0.039 12.6 0.0 1.3 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.16 CDF91441.1 - 0.086 12.2 0.1 0.46 9.8 0.0 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Phospholamban PF04272.9 CDF91441.1 - 9.7 5.7 7.5 19 4.8 0.0 2.7 2 0 0 2 2 2 0 Phospholamban SPC25 PF06703.6 CDF91442.1 - 6.7e-41 139.5 0.3 7.6e-41 139.3 0.2 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) zf-RING_2 PF13639.1 CDF91443.1 - 7.5e-07 28.8 5.4 1.5e-06 27.9 3.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.1 CDF91443.1 - 2.6e-06 27.3 7.4 5.7e-06 26.2 5.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDF91443.1 - 5.1e-06 26.0 4.3 1.3e-05 24.7 3.0 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CDF91443.1 - 1e-05 25.0 4.2 2.3e-05 23.9 2.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDF91443.1 - 1.1e-05 25.0 6.1 2.2e-05 24.0 4.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 CDF91443.1 - 0.00078 19.1 4.1 0.0027 17.3 2.8 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.1 CDF91443.1 - 0.0012 18.7 8.6 0.01 15.7 6.2 2.2 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.3 CDF91443.1 - 0.055 12.9 4.3 0.13 11.8 3.0 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FYVE PF01363.16 CDF91443.1 - 1 9.3 5.5 6.7 6.6 3.8 2.3 1 1 0 1 1 1 0 FYVE zinc finger zf-MIZ PF02891.15 CDF91443.1 - 1.8 8.1 7.1 8.3 6.0 4.9 2.0 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger DUF1900 PF08954.6 CDF91444.1 - 1.1e-46 157.7 0.0 2.7e-46 156.4 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1900) DUF1899 PF08953.6 CDF91444.1 - 1.3e-28 98.3 0.2 2.3e-28 97.6 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40 PF00400.27 CDF91444.1 - 7e-22 76.4 0.6 3.7e-07 29.7 0.0 4.2 5 0 0 5 5 5 3 WD domain, G-beta repeat Nup160 PF11715.3 CDF91444.1 - 1.1e-07 30.3 0.4 0.0006 18.0 0.0 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 eIF2A PF08662.6 CDF91444.1 - 0.0087 15.7 0.0 0.12 12.0 0.0 2.3 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A SEN1_N PF12726.2 CDF91445.1 - 9.3e-229 761.2 20.2 1.3e-228 760.7 14.0 1.2 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.1 CDF91445.1 - 1.2e-67 227.9 0.1 1.2e-67 227.9 0.1 3.2 3 0 0 3 3 3 1 AAA domain AAA_12 PF13087.1 CDF91445.1 - 1.5e-62 210.5 0.3 1.5e-62 210.5 0.2 1.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 CDF91445.1 - 1.9e-11 43.5 0.0 9.2e-11 41.3 0.0 2.1 2 0 0 2 2 2 1 Part of AAA domain AAA_30 PF13604.1 CDF91445.1 - 2.7e-06 27.1 0.0 0.0016 18.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain DEAD PF00270.24 CDF91445.1 - 0.021 14.3 0.5 0.23 10.9 0.0 2.7 3 0 0 3 3 3 0 DEAD/DEAH box helicase UvrD_C_2 PF13538.1 CDF91445.1 - 0.024 14.7 0.0 0.097 12.8 0.0 2.1 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Ykof PF07615.6 CDF91445.1 - 0.073 13.2 0.0 11 6.2 0.0 3.3 3 0 0 3 3 3 0 YKOF-related Family Cortex-I_coil PF09304.5 CDF91446.1 - 0.012 15.6 2.4 0.012 15.6 1.7 3.6 2 1 1 3 3 3 0 Cortexillin I, coiled coil TBCA PF02970.11 CDF91446.1 - 0.3 11.2 10.7 0.047 13.7 0.8 3.7 2 1 2 4 4 4 0 Tubulin binding cofactor A IMPDH PF00478.20 CDF91447.1 - 1.8e-137 457.9 3.1 2.1e-137 457.7 2.2 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.23 CDF91447.1 - 4.6e-12 45.5 0.0 1.2e-05 24.9 0.0 2.6 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.13 CDF91447.1 - 7e-08 31.6 1.0 9.9e-07 27.9 1.4 2.2 2 1 0 2 2 2 1 FMN-dependent dehydrogenase NMO PF03060.10 CDF91447.1 - 2.9e-06 26.6 8.5 0.004 16.3 3.8 2.7 2 1 1 3 3 3 2 Nitronate monooxygenase His_biosynth PF00977.16 CDF91447.1 - 4.9e-05 22.7 3.7 0.0056 15.9 0.1 2.5 1 1 1 2 2 2 2 Histidine biosynthesis protein ThiG PF05690.9 CDF91447.1 - 0.064 12.3 1.7 0.1 11.6 0.3 1.8 1 1 1 2 2 2 0 Thiazole biosynthesis protein ThiG Metallophos PF00149.23 CDF91448.1 - 2.7e-43 147.6 0.4 3.9e-43 147.1 0.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF913 PF06025.7 CDF91448.1 - 0.017 13.8 1.2 0.036 12.8 0.8 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2951 PF11166.3 CDF91448.1 - 0.069 13.0 0.1 0.069 13.0 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2951) WGG PF10273.4 CDF91449.1 - 4.4e-28 97.1 0.4 8.7e-28 96.2 0.3 1.5 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 GOLD_2 PF13897.1 CDF91449.1 - 0.027 14.7 0.7 0.045 13.9 0.5 1.3 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking RRP7 PF12923.2 CDF91449.1 - 0.32 11.0 4.5 0.076 13.0 0.8 1.7 2 1 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) Hid1 PF12722.2 CDF91450.1 - 2.3e-249 829.7 17.9 2.9e-249 829.3 12.4 1.1 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein RNR_inhib PF08591.5 CDF91451.1 - 1.7e-14 54.5 0.0 2.2e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase inhibitor Aminotran_3 PF00202.16 CDF91452.1 - 3.3e-108 361.5 0.0 4e-108 361.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.16 CDF91452.1 - 9.6e-06 24.9 0.0 2.4e-05 23.6 0.0 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 CDF91452.1 - 0.015 14.2 0.0 0.047 12.6 0.0 1.7 2 0 0 2 2 2 0 Aminotransferase class I and II cNMP_binding PF00027.24 CDF91453.1 - 8.7e-42 140.8 1.1 4.9e-18 64.7 0.0 5.5 6 0 0 6 6 6 3 Cyclic nucleotide-binding domain Patatin PF01734.17 CDF91453.1 - 2.5e-19 69.9 0.6 2.5e-12 47.1 0.6 2.9 2 0 0 2 2 2 2 Patatin-like phospholipase LSM PF01423.17 CDF91454.1 - 3.2e-17 61.8 0.0 4.1e-17 61.4 0.0 1.1 1 0 0 1 1 1 1 LSM domain SH3_9 PF14604.1 CDF91454.1 - 0.084 12.4 0.1 1.1 8.9 0.0 2.1 2 0 0 2 2 2 0 Variant SH3 domain DUF2272 PF10030.4 CDF91454.1 - 0.12 11.7 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2272) MRP-L47 PF06984.8 CDF91456.1 - 1.8e-26 91.8 1.3 4e-26 90.7 0.9 1.6 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) MutS_III PF05192.13 CDF91456.1 - 0.012 15.4 0.2 0.28 10.9 0.0 2.3 2 1 0 2 2 2 0 MutS domain III DUF4523 PF15023.1 CDF91456.1 - 0.066 12.7 0.3 0.14 11.6 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) DUF2884 PF11101.3 CDF91456.1 - 0.09 12.1 1.0 0.16 11.3 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) OGG_N PF07934.7 CDF91457.1 - 8.9e-22 77.2 0.3 2.3e-21 75.9 0.1 1.8 2 0 0 2 2 2 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.20 CDF91457.1 - 1.3e-19 70.5 0.0 1.9e-19 69.9 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein PH_8 PF15409.1 CDF91457.1 - 0.13 12.3 0.4 0.43 10.6 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain PIF1 PF05970.9 CDF91458.1 - 5.4e-72 242.7 5.3 1.8e-53 181.7 0.1 2.7 2 1 1 3 3 3 2 PIF1-like helicase AAA_30 PF13604.1 CDF91458.1 - 3.9e-12 46.1 0.0 7.9e-12 45.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CDF91458.1 - 3.1e-07 30.5 0.1 1.9e-06 28.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.16 CDF91458.1 - 0.00035 19.7 0.5 0.00076 18.6 0.1 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 CDF91458.1 - 0.0017 18.0 0.4 0.0034 17.0 0.2 1.5 1 0 0 1 1 1 1 Part of AAA domain Herpes_Helicase PF02689.9 CDF91458.1 - 0.0018 16.1 0.4 0.01 13.6 0.0 2.0 2 0 0 2 2 2 1 Helicase UvrD_C_2 PF13538.1 CDF91458.1 - 0.0024 17.9 0.0 0.011 15.9 0.0 2.2 2 0 0 2 2 1 1 UvrD-like helicase C-terminal domain PhoH PF02562.11 CDF91458.1 - 0.014 14.6 0.1 0.33 10.1 0.0 3.0 4 0 0 4 4 4 0 PhoH-like protein Viral_helicase1 PF01443.13 CDF91458.1 - 0.028 13.9 1.0 10 5.5 0.0 3.1 2 1 0 2 2 2 0 Viral (Superfamily 1) RNA helicase T2SE PF00437.15 CDF91458.1 - 0.03 13.2 0.1 0.054 12.3 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.1 CDF91458.1 - 0.037 13.9 0.1 0.13 12.2 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.24 CDF91458.1 - 0.098 12.8 1.7 0.83 9.8 0.0 3.2 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Sec39 PF08314.6 CDF91459.1 - 6.3e-96 321.9 12.0 9.5e-96 321.3 8.3 1.2 1 0 0 1 1 1 1 Secretory pathway protein Sec39 THOC7 PF05615.8 CDF91460.1 - 1.5e-16 60.9 3.6 1.5e-16 60.9 2.5 2.3 2 1 0 2 2 2 1 Tho complex subunit 7 Fe-ADH_2 PF13685.1 CDF91460.1 - 0.057 12.7 1.1 8.4 5.6 0.0 2.2 2 0 0 2 2 2 0 Iron-containing alcohol dehydrogenase CobT PF06213.7 CDF91460.1 - 0.72 8.9 16.4 1.4 7.9 11.4 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF2457 PF10446.4 CDF91460.1 - 5.9 5.5 18.5 8.4 4.9 12.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TEX19 PF15553.1 CDF91460.1 - 6.8 6.5 14.3 2.6 7.8 0.1 2.2 2 0 0 2 2 2 0 Testis-expressed protein 19 DDHD PF02862.12 CDF91460.1 - 8.9 6.0 11.3 1.9 8.2 3.3 2.0 2 0 0 2 2 2 0 DDHD domain Ribosomal_S3Ae PF01015.13 CDF91461.1 - 8.3e-79 263.4 7.0 9.8e-79 263.2 4.8 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.11 CDF91461.1 - 0.032 13.5 0.0 0.08 12.3 0.0 1.6 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region Ras PF00071.17 CDF91462.1 - 8.3e-30 103.3 0.0 1e-29 102.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDF91462.1 - 1e-17 64.6 0.1 6e-17 62.2 0.0 2.0 2 0 0 2 2 2 1 Miro-like protein Arf PF00025.16 CDF91462.1 - 5.1e-06 25.8 0.1 6.3e-06 25.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 CDF91462.1 - 7.2e-05 22.0 0.1 8.6e-05 21.7 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.5 CDF91462.1 - 0.11 11.7 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA PF00004.24 CDF91463.1 - 2.2e-19 69.9 0.0 5.4e-19 68.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BAH PF01426.13 CDF91463.1 - 2.5e-16 59.4 0.1 8e-16 57.8 0.0 2.0 1 0 0 1 1 1 1 BAH domain AAA_16 PF13191.1 CDF91463.1 - 6.8e-09 35.9 0.0 1.2e-06 28.6 0.0 2.7 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.1 CDF91463.1 - 1e-06 28.8 0.1 1e-05 25.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.7 CDF91463.1 - 6.9e-06 25.8 0.0 4e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 NACHT domain Arch_ATPase PF01637.13 CDF91463.1 - 7.4e-05 22.5 0.1 7.4e-05 22.5 0.0 3.7 4 1 0 4 4 3 1 Archaeal ATPase AAA_17 PF13207.1 CDF91463.1 - 0.0043 17.8 0.1 0.027 15.2 0.0 2.5 2 0 0 2 2 1 1 AAA domain DUF1075 PF06388.6 CDF91463.1 - 0.0095 15.5 1.1 0.0095 15.5 0.8 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF1075) AAA_18 PF13238.1 CDF91463.1 - 0.031 14.5 0.0 0.031 14.5 0.0 3.6 4 0 0 4 4 4 0 AAA domain ArgK PF03308.11 CDF91463.1 - 0.066 11.9 0.0 0.14 10.8 0.0 1.5 1 0 0 1 1 1 0 ArgK protein YL1 PF05764.8 CDF91463.1 - 4.7 6.7 47.7 1.5 8.3 15.4 2.5 2 0 0 2 2 2 0 YL1 nuclear protein SUR7 PF06687.7 CDF91464.1 - 6.9e-12 45.3 7.4 9.5e-12 44.9 5.1 1.2 1 0 0 1 1 1 1 SUR7/PalI family DUF912 PF06024.7 CDF91464.1 - 1.1 9.3 3.3 4.9 7.2 0.1 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) SUR7 PF06687.7 CDF91465.1 - 0.0037 16.8 1.0 0.0037 16.8 0.7 2.7 2 1 0 2 2 2 1 SUR7/PalI family DUF202 PF02656.10 CDF91465.1 - 0.13 12.4 3.1 0.48 10.6 2.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF202) COPIIcoated_ERV PF07970.7 CDF91466.1 - 7.8e-28 97.6 0.0 1.2e-27 97.0 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.1 CDF91466.1 - 1.4e-17 63.4 0.0 2.5e-17 62.6 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) IBR PF01485.16 CDF91468.1 - 1.6e-10 40.7 49.8 1.3e-08 34.6 1.8 3.9 3 1 1 4 4 4 2 IBR domain zf-RING_2 PF13639.1 CDF91468.1 - 1.8e-06 27.6 7.4 1.8e-06 27.6 5.1 4.6 3 2 1 4 4 4 1 Ring finger domain zf-C3HC4_2 PF13923.1 CDF91468.1 - 0.00052 19.9 10.6 0.00052 19.9 7.3 5.1 3 2 2 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDF91468.1 - 0.00091 18.8 10.9 0.00091 18.8 7.6 4.9 3 2 2 5 5 5 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDF91468.1 - 0.0012 18.5 8.4 0.0012 18.5 5.9 4.2 3 1 1 4 4 4 1 zinc-RING finger domain zf-RING_UBOX PF13445.1 CDF91468.1 - 0.0046 16.6 4.3 0.0046 16.6 3.0 4.1 3 1 1 4 4 4 1 RING-type zinc-finger SSrecog PF03531.9 CDF91469.1 - 1.6e-70 236.9 2.7 5.8e-42 143.5 0.2 2.5 1 1 0 2 2 2 2 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.7 CDF91469.1 - 1.5e-28 98.5 0.0 7.8e-27 93.0 0.0 3.1 3 0 0 3 3 3 1 Histone chaperone Rttp106-like Dak1 PF02733.12 CDF91470.1 - 2.3e-130 433.9 2.3 3e-130 433.5 1.6 1.1 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.12 CDF91470.1 - 1e-44 152.3 1.7 2e-44 151.3 0.3 2.1 3 0 0 3 3 3 1 DAK2 domain BAR PF03114.13 CDF91471.1 - 0.00015 21.3 0.2 0.0017 17.9 0.0 2.3 2 1 0 2 2 2 1 BAR domain Zn_clus PF00172.13 CDF91472.1 - 2.5e-05 24.0 6.1 5.9e-05 22.8 4.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hexokinase_1 PF00349.16 CDF91473.1 - 3.9e-15 55.7 0.0 6.5e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.11 CDF91473.1 - 0.13 11.4 0.0 0.99 8.5 0.0 2.3 3 0 0 3 3 3 0 Hexokinase Cyt-b5 PF00173.23 CDF91474.1 - 1.2e-08 34.6 0.0 2.1e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain vATP-synt_AC39 PF01992.11 CDF91475.1 - 2.7e-83 279.9 0.0 3.1e-83 279.6 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Dor1 PF04124.7 CDF91476.1 - 1e-38 132.6 8.0 2e-35 121.8 1.7 2.1 2 0 0 2 2 2 2 Dor1-like family Sec5 PF15469.1 CDF91476.1 - 1.6e-05 24.7 0.9 6.5e-05 22.7 0.0 2.3 2 1 0 2 2 2 1 Exocyst complex component Sec5 DUF2587 PF10759.4 CDF91476.1 - 0.039 13.3 0.0 0.099 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2587) C2 PF00168.25 CDF91477.1 - 8.4e-41 137.7 2.2 8.6e-16 57.5 0.1 5.7 5 0 0 5 5 5 4 C2 domain DOCK-C2 PF14429.1 CDF91477.1 - 0.013 15.1 1.1 0.67 9.5 0.0 3.5 4 0 0 4 4 4 0 C2 domain in Dock180 and Zizimin proteins DUF4250 PF14056.1 CDF91477.1 - 0.014 15.0 0.1 0.042 13.5 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) DUF92 PF01940.11 CDF91477.1 - 0.15 11.2 0.3 0.25 10.4 0.2 1.2 1 0 0 1 1 1 0 Integral membrane protein DUF92 Oxidored_q3 PF00499.15 CDF91477.1 - 0.32 10.7 3.8 0.76 9.5 2.7 1.5 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Ribosomal_L6e PF01159.14 CDF91478.1 - 8.1e-39 132.2 0.8 1.1e-38 131.8 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L6e FKBP_C PF00254.23 CDF91479.1 - 5.1e-28 96.9 2.4 1.7e-27 95.2 0.0 2.9 3 0 0 3 3 3 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF1168 PF06658.7 CDF91479.1 - 0.0062 16.0 6.8 0.0062 16.0 4.7 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1168) Spore_coat_CotO PF14153.1 CDF91479.1 - 0.58 9.5 30.9 1.8 7.9 6.7 2.4 2 0 0 2 2 2 0 Spore coat protein CotO GAGA_bind PF06217.7 CDF91479.1 - 1.6 8.6 23.7 1.5 8.6 2.1 2.1 2 0 0 2 2 2 0 GAGA binding protein-like family TFIIF_alpha PF05793.7 CDF91479.1 - 1.8 6.8 72.6 0.026 12.9 19.0 2.1 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Daxx PF03344.10 CDF91479.1 - 2.1 6.7 49.9 0.68 8.3 14.5 2.1 2 0 0 2 2 2 0 Daxx Family Neur_chan_memb PF02932.11 CDF91479.1 - 8.1 6.2 11.6 10 5.9 0.3 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region HMG-CoA_red PF00368.13 CDF91480.1 - 3.7e-159 529.3 0.4 5.6e-159 528.7 0.3 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.1 CDF91480.1 - 4.8e-37 127.0 0.7 8.1e-37 126.2 0.0 1.8 2 0 0 2 2 2 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.3 CDF91480.1 - 2.9e-10 39.8 8.7 2.9e-10 39.8 6.0 1.9 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Zn_clus PF00172.13 CDF91481.1 - 2.6e-05 24.0 8.4 4.6e-05 23.2 5.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sybindin PF04099.7 CDF91482.1 - 1.3e-17 63.8 0.3 1.5e-17 63.6 0.2 1.2 1 0 0 1 1 1 1 Sybindin-like family OstA_C PF04453.9 CDF91482.1 - 0.0037 16.4 0.2 0.0044 16.1 0.1 1.2 1 0 0 1 1 1 1 Organic solvent tolerance protein Sedlin_N PF04628.8 CDF91482.1 - 0.0038 17.0 0.2 0.0042 16.9 0.1 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region WBP-1 PF11669.3 CDF91482.1 - 0.065 13.3 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 WW domain-binding protein 1 ENTH PF01417.15 CDF91483.1 - 2.8e-44 149.9 0.0 4.1e-44 149.4 0.0 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.11 CDF91483.1 - 0.056 12.1 0.0 0.1 11.2 0.0 1.4 1 0 0 1 1 1 0 ANTH domain VHS PF00790.14 CDF91483.1 - 0.086 12.4 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 VHS domain DUF3991 PF13154.1 CDF91483.1 - 0.12 12.5 0.1 24 5.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3991) Pro_isomerase PF00160.16 CDF91484.1 - 7.6e-47 159.3 0.1 8.5e-47 159.2 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TFR_dimer PF04253.10 CDF91485.1 - 3.8e-10 39.4 0.4 1.5e-09 37.4 0.0 2.2 3 0 0 3 3 3 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.12 CDF91485.1 - 2.4e-09 37.1 0.0 5.5e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.17 CDF91485.1 - 0.0017 18.0 0.0 0.0032 17.1 0.0 1.5 1 0 0 1 1 1 1 PA domain Cupin_5 PF06172.6 CDF91486.1 - 2.2e-32 111.8 0.0 7e-32 110.2 0.0 1.7 1 1 0 1 1 1 1 Cupin superfamily (DUF985) Dus PF01207.12 CDF91487.1 - 4.6e-77 258.9 0.0 5.8e-77 258.5 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) WHIM3 PF15614.1 CDF91487.1 - 0.14 11.9 0.4 19 5.1 0.1 2.9 3 0 0 3 3 3 0 WSTF, HB1, Itc1p, MBD9 motif 3 zf-H2C2_2 PF13465.1 CDF91488.1 - 2.7e-07 30.5 10.6 2e-05 24.6 3.5 2.8 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.21 CDF91488.1 - 3.7e-07 30.0 13.7 0.0001 22.3 1.5 3.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CDF91488.1 - 0.0023 18.1 2.4 0.0023 18.1 1.6 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger CDK5_activator PF03261.10 CDF91488.1 - 0.036 13.3 12.2 0.08 12.2 8.5 1.5 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Lar_restr_allev PF14354.1 CDF91488.1 - 0.091 13.0 0.2 0.21 11.9 0.2 1.6 1 0 0 1 1 1 0 Restriction alleviation protein Lar Methyltransf_16 PF10294.4 CDF91490.1 - 1.4e-19 70.2 0.0 2.1e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_18 PF12847.2 CDF91490.1 - 7e-07 29.8 0.0 1.1e-06 29.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 CDF91490.1 - 4.2e-06 26.7 1.1 8.3e-06 25.8 0.2 1.8 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.8 CDF91490.1 - 7.5e-05 21.9 0.0 0.00011 21.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 CDF91490.1 - 7.7e-05 22.1 0.0 0.00013 21.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain RrnaAD PF00398.15 CDF91490.1 - 0.00052 19.1 0.0 0.00072 18.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_12 PF08242.7 CDF91490.1 - 0.0006 20.2 0.0 0.0011 19.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 CDF91490.1 - 0.0007 19.2 0.0 0.00093 18.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDF91490.1 - 0.00075 19.9 0.0 0.0017 18.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 CDF91490.1 - 0.001 18.8 0.0 0.0015 18.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.9 CDF91490.1 - 0.0088 15.2 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB UPF0146 PF03686.8 CDF91490.1 - 0.029 14.1 0.0 0.048 13.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) Nefa_Nip30_N PF10187.4 CDF91492.1 - 0.00013 22.0 6.9 0.00013 22.0 4.8 1.7 1 1 0 1 1 1 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 NDT80_PhoG PF05224.7 CDF91493.1 - 2e-65 220.2 0.7 4.1e-65 219.2 0.5 1.5 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family GNAT_acetyltr_2 PF13718.1 CDF91494.1 - 6.1e-79 263.9 0.0 1.5e-78 262.6 0.0 1.7 1 0 0 1 1 1 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.9 CDF91494.1 - 1.6e-65 220.0 0.1 1.2e-64 217.1 0.0 2.5 2 1 0 2 2 2 1 Helicase DUF1726 PF08351.6 CDF91494.1 - 2.6e-40 136.0 1.0 4.3e-40 135.3 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) tRNA_bind_2 PF13725.1 CDF91494.1 - 4.9e-39 132.5 0.3 1.5e-38 130.9 0.2 1.9 1 0 0 1 1 1 1 Possible tRNA binding domain Acetyltransf_7 PF13508.1 CDF91494.1 - 0.017 15.2 0.0 0.072 13.2 0.0 2.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DEAD PF00270.24 CDF91494.1 - 0.029 13.8 0.0 0.12 11.9 0.0 2.0 2 0 0 2 2 2 0 DEAD/DEAH box helicase Sigma70_r4_2 PF08281.7 CDF91494.1 - 0.073 12.5 0.0 0.26 10.7 0.0 1.9 1 0 0 1 1 1 0 Sigma-70, region 4 Tom22 PF04281.8 CDF91495.1 - 3.5e-47 159.3 0.1 3.9e-47 159.2 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 CDP-OH_P_transf PF01066.16 CDF91496.1 - 3.5e-17 62.5 1.9 3.5e-17 62.5 1.3 2.6 3 0 0 3 3 3 1 CDP-alcohol phosphatidyltransferase DUF59 PF01883.14 CDF91497.1 - 1.8e-06 27.8 0.1 3.4e-06 26.9 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function DUF59 AAA_18 PF13238.1 CDF91498.1 - 7.3e-09 36.0 0.1 5.6e-08 33.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 CDF91498.1 - 2.4e-07 31.5 0.1 6e-07 30.2 0.1 1.7 1 1 0 1 1 1 1 AAA domain PRK PF00485.13 CDF91498.1 - 0.00024 20.7 0.0 0.00037 20.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.1 CDF91498.1 - 0.0064 16.3 0.0 0.024 14.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain tRNA_lig_kinase PF08303.6 CDF91498.1 - 0.011 15.5 0.7 0.048 13.5 0.5 1.9 1 1 0 1 1 1 0 tRNA ligase kinase domain AAA_28 PF13521.1 CDF91498.1 - 0.014 15.3 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 CDF91498.1 - 0.014 15.1 0.0 0.029 14.1 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain CPT PF07931.7 CDF91498.1 - 0.023 14.3 0.0 0.033 13.7 0.0 1.6 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein MobB PF03205.9 CDF91498.1 - 0.072 12.8 0.3 0.64 9.7 0.1 2.1 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.22 CDF91498.1 - 0.14 12.4 0.1 0.22 11.8 0.1 1.4 1 1 0 1 1 1 0 ABC transporter DSPc PF00782.15 CDF91499.1 - 5e-11 42.3 0.1 1.1e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 CDF91499.1 - 0.0012 18.1 0.0 0.0027 17.1 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.1 CDF91499.1 - 0.019 15.0 0.0 0.032 14.2 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.1 CDF91499.1 - 0.17 12.1 0.1 0.34 11.1 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family AD PF09793.4 CDF91500.1 - 3.6e-27 94.0 0.4 6.2e-27 93.2 0.2 1.4 1 0 0 1 1 1 1 Anticodon-binding domain LSM14 PF12701.2 CDF91500.1 - 0.03 14.1 0.5 0.39 10.5 0.3 2.2 1 1 0 1 1 1 0 Scd6-like Sm domain IL15 PF02372.10 CDF91500.1 - 0.05 13.3 0.1 0.075 12.8 0.1 1.3 1 0 0 1 1 1 0 Interleukin 15 DUF3402 PF11882.3 CDF91501.1 - 4.2e-83 279.6 5.9 4.2e-83 279.6 4.1 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF3402) N1221 PF07923.8 CDF91501.1 - 3e-67 226.5 2.9 4.7e-67 225.9 2.0 1.3 1 0 0 1 1 1 1 N1221-like protein Spc97_Spc98 PF04130.8 CDF91502.1 - 1.8e-63 214.7 21.5 1.8e-63 214.7 14.9 1.7 2 0 0 2 2 2 1 Spc97 / Spc98 family MFS_1 PF07690.11 CDF91503.1 - 5e-21 74.8 34.3 1.7e-20 73.0 23.3 2.1 1 1 2 3 3 3 2 Major Facilitator Superfamily MFS_2 PF13347.1 CDF91503.1 - 1.9e-09 36.4 9.5 1.9e-09 36.4 6.6 2.1 1 1 1 2 2 2 1 MFS/sugar transport protein DUF2124 PF09897.4 CDF91503.1 - 0.099 12.3 0.2 0.29 10.7 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2124) DUF4244 PF14029.1 CDF91503.1 - 0.11 11.6 0.4 0.97 8.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4244) Gar1 PF04410.9 CDF91504.1 - 2.8e-44 150.2 0.5 2.8e-44 150.2 0.3 2.5 3 0 0 3 3 3 1 Gar1/Naf1 RNA binding region MutS_V PF00488.16 CDF91505.1 - 7.6e-76 254.5 0.0 1.5e-75 253.6 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.13 CDF91505.1 - 1e-33 116.8 4.0 2.4e-33 115.6 2.8 1.7 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.15 CDF91505.1 - 9.3e-26 90.0 0.0 3.1e-25 88.4 0.0 2.0 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.12 CDF91505.1 - 2e-09 37.6 0.1 1.6e-08 34.7 0.0 2.4 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.13 CDF91505.1 - 0.00099 19.2 1.7 0.0019 18.3 0.2 2.3 2 0 0 2 2 2 1 MutS family domain IV N-SET PF11764.3 CDF91506.1 - 2.6e-41 141.2 0.5 2.6e-41 141.2 0.4 2.8 2 0 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component N SET PF00856.23 CDF91506.1 - 4.6e-23 82.3 0.1 4.6e-23 82.3 0.1 3.5 4 1 0 4 4 4 1 SET domain SET_assoc PF11767.3 CDF91506.1 - 2.7e-21 74.6 0.0 2.1e-20 71.8 0.0 2.4 2 0 0 2 2 2 1 Histone lysine methyltransferase SET associated ORC6 PF05460.8 CDF91507.1 - 1.6e-89 300.4 3.0 1.8e-89 300.3 2.0 1.0 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) Ribosomal_L35p PF01632.14 CDF91508.1 - 8.7e-11 41.5 6.4 1.2e-10 41.1 4.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L35 TPR_11 PF13414.1 CDF91509.1 - 8.9e-34 114.9 30.8 6.5e-15 54.5 0.1 7.2 3 2 2 7 7 7 6 TPR repeat TPR_2 PF07719.12 CDF91509.1 - 2.5e-22 76.9 37.0 0.0015 18.3 0.5 11.5 9 2 2 11 11 11 5 Tetratricopeptide repeat TPR_1 PF00515.23 CDF91509.1 - 5.8e-21 73.1 41.9 2e-06 27.1 1.1 10.9 10 1 1 11 11 11 5 Tetratricopeptide repeat TPR_16 PF13432.1 CDF91509.1 - 2.6e-20 72.5 19.7 9.5e-05 22.9 0.6 6.4 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.1 CDF91509.1 - 1.7e-16 59.9 20.0 7.1e-05 22.6 0.0 7.6 3 2 4 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.1 CDF91509.1 - 9.4e-16 56.3 34.8 0.0073 16.0 0.6 8.7 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_14 PF13428.1 CDF91509.1 - 7.4e-14 51.0 12.6 0.26 12.0 0.1 8.1 5 4 3 8 8 7 4 Tetratricopeptide repeat TPR_19 PF14559.1 CDF91509.1 - 3.3e-13 49.7 23.8 0.00016 21.9 2.8 6.2 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.1 CDF91509.1 - 1.1e-12 47.0 16.2 0.00049 20.0 0.1 8.9 8 1 0 8 8 8 2 Tetratricopeptide repeat Apc3 PF12895.2 CDF91509.1 - 1e-07 31.9 21.6 0.014 15.5 2.0 5.3 4 1 2 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.1 CDF91509.1 - 2.9e-06 26.6 18.8 0.23 11.3 0.1 8.1 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_9 PF13371.1 CDF91509.1 - 1.3e-05 24.9 1.1 7.9 6.4 0.0 5.6 5 1 0 5 5 5 0 Tetratricopeptide repeat SPO22 PF08631.5 CDF91509.1 - 8e-05 21.8 1.9 0.003 16.6 0.1 3.3 3 1 0 3 3 3 1 Meiosis protein SPO22/ZIP4 like Exonuc_VII_S PF02609.11 CDF91509.1 - 0.00047 19.8 3.3 0.037 13.8 0.2 4.1 3 0 0 3 3 3 1 Exonuclease VII small subunit TPR_10 PF13374.1 CDF91509.1 - 0.0024 17.7 6.4 9 6.3 0.0 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.1 CDF91509.1 - 0.11 12.9 23.1 14 6.4 0.0 8.0 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_20 PF14561.1 CDF91509.1 - 0.16 12.0 9.3 1.8 8.7 0.9 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat Gti1_Pac2 PF09729.4 CDF91509.1 - 0.37 10.6 3.6 0.92 9.3 2.2 1.6 1 1 0 1 1 1 0 Gti1/Pac2 family TPR_3 PF07720.7 CDF91509.1 - 5.3 6.9 21.4 0.17 11.7 1.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF1903 PF08991.5 CDF91510.1 - 1.7e-05 24.8 3.7 2.5e-05 24.3 2.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1903) CHCH PF06747.8 CDF91510.1 - 0.0002 21.1 8.8 0.00044 20.0 6.1 1.6 1 0 0 1 1 1 1 CHCH domain Pet191_N PF10203.4 CDF91510.1 - 0.06 13.4 4.5 0.08 12.9 3.1 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 UPF0203 PF05254.7 CDF91510.1 - 0.073 12.9 4.6 0.21 11.4 3.2 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) Cmc1 PF08583.5 CDF91510.1 - 0.55 10.0 6.1 0.47 10.2 1.0 2.2 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like DUF2392 PF10288.4 CDF91511.1 - 6.6e-31 106.8 0.1 1.4e-30 105.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2392) DUF3510 PF12022.3 CDF91511.1 - 0.015 15.3 0.6 0.14 12.3 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3510) Ribosomal_L37e PF01907.14 CDF91511.1 - 0.39 10.5 4.2 1.3 8.9 2.9 1.9 1 0 0 1 1 1 0 Ribosomal protein L37e DCP2 PF05026.8 CDF91512.1 - 5.3e-32 109.5 1.4 1.4e-31 108.2 1.0 1.8 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.23 CDF91512.1 - 1.4e-14 53.8 0.0 2.8e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain NMT1 PF09084.6 CDF91513.1 - 1.8e-15 57.1 0.0 4.8e-15 55.7 0.0 1.6 1 1 0 1 1 1 1 NMT1/THI5 like Phosphonate-bd PF12974.2 CDF91513.1 - 8.6e-11 41.6 0.0 1.1e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.15 CDF91513.1 - 1.4e-08 34.3 0.0 2e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 NMT1_2 PF13379.1 CDF91513.1 - 4.7e-07 29.4 0.0 7.4e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 NMT1-like family VitK2_biosynth PF02621.9 CDF91513.1 - 0.019 14.1 0.0 0.035 13.2 0.0 1.4 1 0 0 1 1 1 0 Menaquinone biosynthesis LysR_substrate PF03466.15 CDF91513.1 - 0.033 13.2 0.0 0.056 12.5 0.0 1.4 1 1 0 1 1 1 0 LysR substrate binding domain Malate_synthase PF01274.17 CDF91514.1 - 1.7e-216 719.3 0.0 2.1e-216 719.0 0.0 1.0 1 0 0 1 1 1 1 Malate synthase FHA PF00498.21 CDF91515.1 - 5.3e-14 52.0 0.9 1e-13 51.1 0.0 2.0 2 0 0 2 2 2 1 FHA domain zf-RING_2 PF13639.1 CDF91515.1 - 7.6e-07 28.8 10.0 1.3e-06 28.1 6.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.2 CDF91515.1 - 1.7e-05 24.8 4.7 3.4e-05 23.8 3.3 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger zf-C3HC4 PF00097.20 CDF91515.1 - 0.0007 19.2 11.0 0.0012 18.4 7.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Apc11 PF12861.2 CDF91515.1 - 0.011 15.5 4.5 0.024 14.4 3.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.1 CDF91515.1 - 0.068 13.1 12.0 0.12 12.3 8.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.1 CDF91515.1 - 0.087 12.5 12.0 0.15 11.8 8.3 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-HC5HC2H PF13771.1 CDF91515.1 - 0.23 11.6 6.8 0.6 10.2 4.7 1.7 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-RING-like PF08746.6 CDF91515.1 - 0.36 10.8 6.8 0.81 9.7 4.7 1.6 1 0 0 1 1 1 0 RING-like domain Suf PF05843.9 CDF91515.1 - 0.47 10.1 3.5 0.76 9.4 2.4 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) PAT1 PF09770.4 CDF91515.1 - 2.3 6.3 20.6 2.9 6.0 14.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PHD PF00628.24 CDF91515.1 - 3.7 7.3 9.8 7 6.4 6.8 1.5 1 0 0 1 1 1 0 PHD-finger BAF1_ABF1 PF04684.8 CDF91515.1 - 5.8 5.6 12.6 9 5.0 8.7 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF2417 PF10329.4 CDF91516.1 - 1.2e-70 237.5 5.6 1.7e-70 237.0 3.9 1.2 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Abhydrolase_6 PF12697.2 CDF91516.1 - 5.3e-12 46.1 0.0 7.9e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDF91516.1 - 2.5e-09 37.0 0.0 5.4e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold SH3_9 PF14604.1 CDF91517.1 - 2.6e-24 84.5 0.2 7.4e-11 41.4 0.0 3.3 3 0 0 3 3 3 2 Variant SH3 domain SH3_1 PF00018.23 CDF91517.1 - 4.3e-24 83.6 0.1 1.2e-11 43.7 0.0 2.6 2 0 0 2 2 2 2 SH3 domain FCH PF00611.18 CDF91517.1 - 9.4e-21 73.8 1.1 4.6e-20 71.6 0.0 2.6 2 1 1 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.12 CDF91517.1 - 7.3e-13 47.7 0.1 1.1e-07 31.2 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_3 PF08239.6 CDF91517.1 - 3.8e-05 23.7 0.4 0.19 11.9 0.0 2.5 2 0 0 2 2 2 2 Bacterial SH3 domain IncA PF04156.9 CDF91517.1 - 2.3 7.7 6.6 1.6 8.3 0.3 2.8 3 0 0 3 3 3 0 IncA protein TarH PF02203.10 CDF91517.1 - 2.4 7.9 6.2 0.38 10.5 1.2 2.0 2 1 0 2 2 2 0 Tar ligand binding domain homologue DUF4600 PF15372.1 CDF91517.1 - 6.7 6.9 14.2 2.8 8.1 0.5 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4600) TRAPP PF04051.11 CDF91518.1 - 2.9e-31 108.0 0.2 5.3e-31 107.1 0.2 1.6 1 1 0 1 1 1 1 Transport protein particle (TRAPP) component DHQ_synthase PF01761.15 CDF91519.1 - 0.12 11.3 0.1 0.17 10.7 0.1 1.2 1 0 0 1 1 1 0 3-dehydroquinate synthase zf-H2C2_2 PF13465.1 CDF91520.1 - 4.1e-23 80.4 23.4 9.9e-10 38.2 0.7 4.8 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2 PF00096.21 CDF91520.1 - 5.8e-14 51.4 46.3 3.5e-05 23.8 0.1 5.4 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CDF91520.1 - 1.6e-08 34.3 43.4 0.0015 18.7 0.3 5.3 6 0 0 6 6 6 4 C2H2-type zinc finger zf-met PF12874.2 CDF91520.1 - 0.00011 22.2 10.9 0.031 14.4 0.1 4.6 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 CDF91520.1 - 0.016 15.0 0.6 0.016 15.0 0.4 4.5 5 0 0 5 5 5 0 C2H2-type zinc finger zf-Di19 PF05605.7 CDF91520.1 - 0.089 12.9 0.3 0.089 12.9 0.2 3.0 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.3 CDF91520.1 - 0.23 11.6 0.0 0.23 11.6 0.0 5.6 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding TFIIA PF03153.8 CDF91520.1 - 0.25 11.2 43.5 0.34 10.7 8.4 2.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit zf-CHCC PF10276.4 CDF91520.1 - 0.38 10.6 10.3 6 6.7 0.7 3.4 3 0 0 3 3 3 0 Zinc-finger domain RNA_pol_L_2 PF13656.1 CDF91521.1 - 1.7e-31 107.4 0.0 2.3e-31 107.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 CDF91521.1 - 2.4e-12 45.7 0.0 3.3e-12 45.3 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DEAD PF00270.24 CDF91522.1 - 7.7e-46 155.6 0.0 2.2e-44 150.9 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 CDF91522.1 - 3.3e-29 100.5 0.0 8.2e-29 99.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDF91522.1 - 0.00087 19.1 0.0 0.0027 17.5 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF1253 PF06862.7 CDF91522.1 - 0.00098 17.6 0.0 0.0086 14.5 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1253) Helicase_C_2 PF13307.1 CDF91522.1 - 0.023 14.6 0.0 0.039 13.8 0.0 1.3 1 0 0 1 1 1 0 Helicase C-terminal domain Cnd1 PF12717.2 CDF91523.1 - 4.9e-05 23.2 0.8 0.0078 16.0 0.0 3.5 2 1 2 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.17 CDF91523.1 - 6.8e-05 22.6 0.0 1.7 8.9 0.0 4.3 4 0 0 4 4 4 2 HEAT repeat CLASP_N PF12348.3 CDF91523.1 - 0.0013 18.1 0.1 0.018 14.3 0.0 2.5 1 1 2 3 3 3 1 CLASP N terminal Cyt-b5 PF00173.23 CDF91524.1 - 1.9e-25 88.4 0.0 2.6e-25 87.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain RRM_1 PF00076.17 CDF91525.1 - 2.5e-20 71.8 0.1 5.2e-20 70.8 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF91525.1 - 2.2e-13 50.0 0.1 1.3e-12 47.5 0.0 2.2 2 1 0 2 2 2 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF91525.1 - 2.4e-10 40.1 0.1 4.5e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.3 CDF91525.1 - 0.005 16.5 0.2 0.029 14.1 0.0 2.4 1 1 1 2 2 2 1 Limkain b1 Amidinotransf PF02274.12 CDF91525.1 - 0.092 11.8 0.1 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Amidinotransferase DUF3713 PF12506.3 CDF91525.1 - 1.5 8.9 7.1 0.34 11.0 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3713) Maf PF02545.9 CDF91526.1 - 1.2e-49 168.1 0.0 1.4e-49 167.8 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein His_Phos_1 PF00300.17 CDF91527.1 - 1.5e-21 77.1 0.0 3.5e-21 75.9 0.0 1.6 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) TFIIIC_sub6 PF10419.4 CDF91527.1 - 1e-15 56.8 0.0 2.2e-15 55.8 0.0 1.6 1 0 0 1 1 1 1 TFIIIC subunit YEATS PF03366.11 CDF91528.1 - 3.1e-35 119.7 1.2 5.7e-35 118.8 0.8 1.5 1 0 0 1 1 1 1 YEATS family Syja_N PF02383.13 CDF91529.1 - 6.5e-91 304.4 0.4 1e-90 303.7 0.3 1.3 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.18 CDF91529.1 - 3.1e-26 92.8 0.0 6.5e-26 91.7 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family HMGL-like PF00682.14 CDF91530.1 - 9.2e-76 254.6 0.0 1.3e-75 254.0 0.0 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.5 CDF91530.1 - 9.3e-26 90.1 0.0 1.9e-25 89.1 0.0 1.6 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain RGS PF00615.14 CDF91531.1 - 2.5e-12 46.9 0.0 5.4e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain bZIP_2 PF07716.10 CDF91532.1 - 0.0014 18.4 3.5 0.0041 16.9 2.5 1.9 1 0 0 1 1 1 1 Basic region leucine zipper DUF2175 PF09943.4 CDF91532.1 - 5.1 7.2 7.1 1.4 9.0 1.9 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) SNARE PF05739.14 CDF91533.1 - 3.8e-15 55.3 8.4 3.8e-15 55.3 5.8 2.6 3 1 0 3 3 2 1 SNARE domain Syntaxin_2 PF14523.1 CDF91533.1 - 1.7e-07 31.1 0.7 1.7e-07 31.1 0.5 3.0 2 2 0 2 2 1 1 Syntaxin-like protein Synaptobrevin PF00957.16 CDF91533.1 - 0.0021 17.6 1.9 0.0021 17.6 1.3 2.2 2 0 0 2 2 2 1 Synaptobrevin Filament PF00038.16 CDF91533.1 - 0.011 15.2 22.6 0.021 14.2 15.7 1.4 1 1 0 1 1 1 0 Intermediate filament protein Herpes_US9 PF06072.6 CDF91533.1 - 0.018 14.8 0.1 0.034 13.9 0.1 1.5 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 T2SF PF00482.18 CDF91533.1 - 0.23 11.3 0.1 0.23 11.3 0.1 2.3 2 1 0 2 2 2 0 Type II secretion system (T2SS), protein F Mnd1 PF03962.10 CDF91533.1 - 0.26 10.9 21.7 0.28 10.8 9.0 2.6 2 1 0 2 2 2 0 Mnd1 family TSC22 PF01166.13 CDF91533.1 - 0.41 10.6 0.1 0.41 10.6 0.1 4.1 5 0 0 5 5 5 0 TSC-22/dip/bun family TMPIT PF07851.8 CDF91533.1 - 0.48 9.4 11.7 0.029 13.4 4.4 1.7 2 1 0 2 2 2 0 TMPIT-like protein DUF2839 PF10999.3 CDF91533.1 - 1.6 8.8 3.4 2.7 8.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2839) TPR_MLP1_2 PF07926.7 CDF91533.1 - 5.1 6.8 29.5 2.3 7.9 12.9 3.1 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF3708 PF12501.3 CDF91533.1 - 6.2 6.6 8.9 0.37 10.6 1.0 2.1 1 1 1 2 2 2 0 Phosphate ATP-binding cassette transporter DNA_pol_B PF00136.16 CDF91534.1 - 7.4e-112 374.4 2.9 1.4e-111 373.6 2.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.5 CDF91534.1 - 7.7e-64 214.5 2.3 1.6e-63 213.5 1.6 1.6 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.14 CDF91534.1 - 2.1e-45 155.0 0.0 4.9e-45 153.7 0.0 1.6 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.3 CDF91534.1 - 5.8e-17 61.2 9.0 1.9e-16 59.6 6.3 1.9 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal zinc_ribbon_5 PF13719.1 CDF91534.1 - 0.091 12.3 2.9 6.4 6.4 0.1 2.6 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 CDF91534.1 - 0.23 11.1 3.1 14 5.5 0.1 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Aa_trans PF01490.13 CDF91535.1 - 5.6e-95 318.2 36.2 7.1e-95 317.8 25.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF1049 PF06305.6 CDF91535.1 - 1.4 8.4 5.6 0.25 10.8 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) ApoO PF09769.4 CDF91536.1 - 1.6e-06 27.9 0.9 0.044 13.4 0.0 2.9 2 1 1 3 3 3 2 Apolipoprotein O Y_phosphatase2 PF03162.8 CDF91538.1 - 2.6e-56 189.5 0.0 3.3e-56 189.1 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.1 CDF91538.1 - 8.7e-06 26.0 0.0 4.1e-05 23.8 0.0 1.9 1 1 1 2 2 2 1 Tyrosine phosphatase family DSPc PF00782.15 CDF91538.1 - 0.1 12.2 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain DAD PF02109.11 CDF91539.1 - 7.3e-37 125.8 2.6 8.8e-37 125.6 1.8 1.1 1 0 0 1 1 1 1 DAD family DUF3040 PF11239.3 CDF91539.1 - 0.14 12.1 0.6 0.22 11.5 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Ras PF00071.17 CDF91540.1 - 2.8e-56 189.3 0.2 3.7e-56 188.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDF91540.1 - 9.6e-20 71.2 0.1 1.5e-19 70.6 0.1 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDF91540.1 - 1.9e-09 37.0 0.1 2.3e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.18 CDF91540.1 - 6.1e-05 22.9 0.0 0.0001 22.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.22 CDF91540.1 - 6.4e-05 22.4 0.1 0.00031 20.2 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_25 PF13481.1 CDF91540.1 - 0.13 11.6 0.2 0.21 10.9 0.1 1.5 1 1 0 1 1 1 0 AAA domain ING PF12998.2 CDF91541.1 - 3.5e-22 78.6 0.0 1.2e-21 76.9 0.0 1.8 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.24 CDF91541.1 - 1.1e-08 34.5 8.3 2e-08 33.7 5.7 1.4 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.1 CDF91541.1 - 0.032 14.3 1.1 0.067 13.3 0.8 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain NdhM PF10664.4 CDF91541.1 - 0.15 11.9 0.0 0.78 9.6 0.0 2.1 2 1 1 3 3 3 0 Cyanobacterial and plastid NDH-1 subunit M Mito_carr PF00153.22 CDF91542.1 - 9.2e-55 182.3 4.0 5.4e-18 64.4 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Chorion_2 PF03964.10 CDF91542.1 - 0.076 13.5 0.1 0.19 12.2 0.1 1.8 1 0 0 1 1 1 0 Chorion family 2 Glyco_transf_15 PF01793.11 CDF91543.1 - 3.1e-140 466.8 5.8 3.8e-140 466.5 4.0 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Pellino PF04710.9 CDF91544.1 - 0.068 11.8 0.4 0.1 11.2 0.3 1.1 1 0 0 1 1 1 0 Pellino RseC_MucC PF04246.7 CDF91545.1 - 0.11 12.0 1.1 0.16 11.5 0.8 1.2 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Ribosomal_S7e PF01251.13 CDF91546.1 - 1.3e-80 269.4 1.5 1.5e-80 269.1 1.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Rib_5-P_isom_A PF06026.9 CDF91547.1 - 1.9e-52 177.1 0.0 2.3e-52 176.7 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.17 CDF91547.1 - 0.013 15.1 0.0 5.8 6.5 0.0 2.2 2 0 0 2 2 2 0 DeoR C terminal sensor domain Arf PF00025.16 CDF91548.1 - 6.3e-71 237.2 0.2 7.1e-71 237.0 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.5 CDF91548.1 - 4.5e-14 52.0 0.0 5.6e-14 51.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.17 CDF91548.1 - 1.7e-13 50.3 0.0 2e-13 50.0 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.15 CDF91548.1 - 3.1e-12 45.8 0.9 6.1e-08 31.7 0.1 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.7 CDF91548.1 - 1.1e-10 41.0 0.0 1.3e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Miro PF08477.8 CDF91548.1 - 1.2e-08 35.5 0.0 1.6e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 Miro-like protein MMR_HSR1 PF01926.18 CDF91548.1 - 1.3e-06 28.3 0.0 1.7e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.13 CDF91548.1 - 0.082 11.9 0.1 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_14 PF13173.1 CDF91548.1 - 0.1 12.4 0.2 0.57 10.0 0.1 2.1 1 1 0 1 1 1 0 AAA domain AMP-binding PF00501.23 CDF91549.1 - 1.5e-37 129.0 0.0 5.5e-16 57.9 0.0 4.5 4 1 0 4 4 4 4 AMP-binding enzyme DMAP_binding PF06464.6 CDF91549.1 - 1.3e-10 41.7 0.1 1.3e-10 41.7 0.0 2.5 3 0 0 3 3 3 1 DMAP1-binding Domain Peptidase_M16 PF00675.15 CDF91549.1 - 0.011 15.5 0.3 0.053 13.2 0.0 2.2 2 0 0 2 2 2 0 Insulinase (Peptidase family M16) Mem_trans PF03547.13 CDF91550.1 - 2.4e-78 263.1 0.0 5.3e-78 261.9 0.0 1.5 1 1 0 1 1 1 1 Membrane transport protein Ribosomal_L16 PF00252.13 CDF91551.1 - 7.1e-34 116.4 0.3 1e-33 115.9 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Rep_fac_C PF08542.6 CDF91552.1 - 8.2e-21 73.7 0.6 6.4e-20 70.9 0.1 2.4 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.1 CDF91552.1 - 1.5e-13 50.7 0.2 9.5e-13 48.1 0.0 2.1 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA PF00004.24 CDF91552.1 - 3.8e-07 30.3 0.4 1.4e-06 28.5 0.0 2.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.8 CDF91552.1 - 9.7e-06 25.1 0.0 0.00029 20.3 0.0 2.3 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA_22 PF13401.1 CDF91552.1 - 0.00013 22.1 0.4 0.0016 18.5 0.1 2.7 2 1 1 3 3 3 1 AAA domain Rad17 PF03215.10 CDF91552.1 - 0.00022 20.0 0.2 0.00057 18.6 0.0 1.8 2 0 0 2 2 2 1 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 CDF91552.1 - 0.0023 17.9 0.1 0.013 15.5 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain Sigma54_activ_2 PF14532.1 CDF91552.1 - 0.0048 16.9 0.1 1.1 9.3 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_10 PF12846.2 CDF91552.1 - 0.016 14.6 0.2 0.17 11.3 0.0 2.1 1 1 0 2 2 2 0 AAA-like domain RuvB_N PF05496.7 CDF91552.1 - 0.03 13.3 0.1 0.28 10.2 0.0 2.4 2 1 1 3 3 3 0 Holliday junction DNA helicase ruvB N-terminus Adaptin_N PF01602.15 CDF91553.1 - 1.8e-105 353.3 19.5 2.1e-105 353.0 13.5 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.15 CDF91553.1 - 5.1e-10 39.6 1.7 6e-10 39.4 0.1 2.0 2 0 0 2 2 2 1 Adaptin C-terminal domain Alpha_adaptin_C PF02296.11 CDF91553.1 - 6.6e-06 26.0 0.2 2.7e-05 24.0 0.0 2.2 2 1 0 2 2 2 1 Alpha adaptin AP2, C-terminal domain Sybindin PF04099.7 CDF91553.1 - 0.032 13.9 0.0 0.076 12.7 0.0 1.6 1 0 0 1 1 1 0 Sybindin-like family Ala_racemase_N PF01168.15 CDF91554.1 - 3.1e-41 141.3 0.0 3.9e-41 141.0 0.0 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain DHQS PF01959.11 CDF91554.1 - 0.089 11.4 0.0 0.16 10.6 0.0 1.4 1 0 0 1 1 1 0 3-dehydroquinate synthase (EC 4.6.1.3) Anoctamin PF04547.7 CDF91555.1 - 9.4e-42 143.2 13.9 1.3e-39 136.1 9.6 2.5 1 1 0 1 1 1 1 Calcium-activated chloride channel Pol_alpha_B_N PF08418.5 CDF91556.1 - 2.2e-67 227.2 2.6 3e-67 226.8 1.8 1.2 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.11 CDF91556.1 - 5.8e-49 166.1 0.1 8.7e-49 165.6 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B CLASP_N PF12348.3 CDF91557.1 - 3.1e-60 203.3 10.1 3.1e-60 203.3 7.0 2.8 3 0 0 3 3 3 1 CLASP N terminal DUF4005 PF13178.1 CDF91557.1 - 0.17 12.1 5.8 0.4 10.9 4.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4005) YvfG PF09628.5 CDF91558.1 - 0.047 13.8 0.0 0.068 13.3 0.0 1.2 1 0 0 1 1 1 0 YvfG protein DUF4641 PF15483.1 CDF91558.1 - 0.078 11.6 0.0 0.081 11.6 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4641) GTP_cyclohydro2 PF00925.15 CDF91559.1 - 1.9e-55 186.6 0.0 1.1e-50 171.1 0.0 2.1 2 0 0 2 2 2 2 GTP cyclohydrolase II KH_1 PF00013.24 CDF91560.1 - 1.8e-28 97.9 1.1 9.6e-10 37.9 0.0 3.4 3 0 0 3 3 3 3 KH domain KH_3 PF13014.1 CDF91560.1 - 3.6e-21 74.3 3.4 9.9e-08 31.4 0.0 3.5 3 0 0 3 3 3 3 KH domain KH_2 PF07650.12 CDF91560.1 - 4.5e-10 38.9 5.6 0.0014 18.1 0.1 3.8 3 1 0 3 3 3 3 KH domain KH_4 PF13083.1 CDF91560.1 - 1.4e-05 24.6 0.0 0.28 10.8 0.0 3.6 3 0 0 3 3 3 2 KH domain KH_5 PF13184.1 CDF91560.1 - 0.012 15.3 3.0 2.2 8.1 0.1 3.2 3 0 0 3 3 3 0 NusA-like KH domain Eapp_C PF10238.4 CDF91560.1 - 2.3 8.1 4.1 20 5.0 0.1 2.4 2 0 0 2 2 2 0 E2F-associated phosphoprotein Mito_carr PF00153.22 CDF91561.1 - 2.1e-70 232.4 4.2 1.2e-24 85.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein zf-BED PF02892.10 CDF91562.1 - 0.011 15.4 0.4 1.7 8.4 0.1 2.3 2 0 0 2 2 2 0 BED zinc finger Zn_Tnp_IS1595 PF12760.2 CDF91562.1 - 0.036 13.8 3.9 0.21 11.4 2.7 2.0 1 1 0 1 1 1 0 Transposase zinc-ribbon domain zf-LITAF-like PF10601.4 CDF91562.1 - 0.046 13.5 1.1 0.14 12.0 0.8 1.8 1 1 0 1 1 1 0 LITAF-like zinc ribbon domain zf-Sec23_Sec24 PF04810.10 CDF91562.1 - 0.1 12.1 0.8 0.1 12.1 0.5 2.7 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger zf-CHY PF05495.7 CDF91562.1 - 0.13 12.3 1.4 0.92 9.7 0.8 1.9 1 1 1 2 2 2 0 CHY zinc finger Cys_rich_CPCC PF14206.1 CDF91562.1 - 0.15 11.6 1.1 0.35 10.4 0.1 1.9 2 0 0 2 2 2 0 Cysteine-rich CPCC DUF2423 PF10338.4 CDF91564.1 - 3e-12 46.2 4.3 3e-12 46.2 3.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) FYDLN_acid PF09538.5 CDF91564.1 - 0.029 14.9 1.5 0.033 14.7 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DUF2870 PF11069.3 CDF91564.1 - 0.53 10.3 4.5 0.71 9.9 3.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2870) Ribosomal_L19e PF01280.15 CDF91565.1 - 2.3e-58 196.1 11.2 2.3e-58 196.1 7.8 1.5 1 1 0 1 1 1 1 Ribosomal protein L19e FTHFS PF01268.14 CDF91567.1 - 3.1e-253 840.8 0.4 3.9e-253 840.5 0.2 1.1 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.14 CDF91567.1 - 1.9e-68 228.6 0.1 1.9e-68 228.6 0.1 1.9 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.18 CDF91567.1 - 4.8e-34 116.8 0.1 1.1e-33 115.7 0.0 1.7 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain TEA PF01285.13 CDF91568.1 - 2.7e-30 105.8 8.7 3e-30 105.7 0.0 2.1 2 0 0 2 2 2 1 TEA/ATTS domain family Neur_chan_memb PF02932.11 CDF91568.1 - 0.043 13.6 1.7 0.06 13.2 1.2 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.17 CDF91568.1 - 0.045 12.7 8.0 0.064 12.2 5.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter PP1_bind PF15276.1 CDF91568.1 - 0.059 13.3 1.5 0.2 11.6 1.1 2.0 1 0 0 1 1 1 0 Protein phosphatase 1 binding PAT1 PF09770.4 CDF91568.1 - 0.14 10.3 26.2 0.2 9.8 18.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4175 PF13779.1 CDF91568.1 - 0.36 8.4 21.3 0.57 7.8 14.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF3984 PF13136.1 CDF91568.1 - 3.8 6.6 15.8 8 5.5 10.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) DUF2217 PF10265.4 CDF91568.1 - 7.4 5.2 13.0 0.66 8.6 5.8 1.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2217) CBF PF03914.12 CDF91569.1 - 2.9e-44 150.4 0.9 2.9e-44 150.4 0.6 2.6 3 0 0 3 3 3 1 CBF/Mak21 family Tim54 PF11711.3 CDF91569.1 - 5.6 5.4 13.5 7.1 5.1 6.4 2.5 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 UQ_con PF00179.21 CDF91570.1 - 3.4e-51 172.3 0.0 3.8e-51 172.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.1 CDF91570.1 - 6e-05 22.8 0.0 7.2e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.17 CDF91570.1 - 0.00035 20.4 0.0 0.0004 20.2 0.0 1.2 1 0 0 1 1 1 1 RWD domain UEV PF05743.8 CDF91570.1 - 0.015 14.9 0.0 0.024 14.3 0.0 1.3 1 0 0 1 1 1 0 UEV domain Bromodomain PF00439.20 CDF91571.1 - 1.5e-17 63.3 2.4 2.7e-17 62.4 0.4 2.5 2 0 0 2 2 2 1 Bromodomain Bromo_TP PF07524.8 CDF91571.1 - 7.2e-05 22.4 0.0 0.0039 16.8 0.0 2.5 2 0 0 2 2 2 1 Bromodomain associated PRKCSH PF07915.8 CDF91572.1 - 2.3e-09 37.8 3.1 2.4e-09 37.8 0.8 2.1 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein AAA PF00004.24 CDF91574.1 - 1e-52 177.8 0.0 5.2e-38 130.2 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 CDF91574.1 - 4.9e-12 45.6 0.0 2.9e-11 43.1 0.0 2.2 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain CDC48_2 PF02933.12 CDF91574.1 - 1e-10 41.0 0.1 7.8e-10 38.2 0.0 2.3 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_22 PF13401.1 CDF91574.1 - 4.9e-10 39.6 0.5 0.00071 19.7 0.1 3.5 2 2 0 2 2 2 2 AAA domain AAA_19 PF13245.1 CDF91574.1 - 6.7e-10 38.5 0.2 0.00096 18.8 0.0 2.6 2 0 0 2 2 2 2 Part of AAA domain TIP49 PF06068.8 CDF91574.1 - 1.4e-09 37.2 0.2 0.00023 20.0 0.0 2.3 2 0 0 2 2 2 2 TIP49 C-terminus AAA_17 PF13207.1 CDF91574.1 - 4.2e-09 37.2 0.2 0.0054 17.5 0.1 2.8 2 1 0 2 2 2 2 AAA domain AAA_33 PF13671.1 CDF91574.1 - 7.2e-08 32.4 0.0 0.0025 17.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 CDF91574.1 - 8.8e-08 32.3 0.0 0.012 15.6 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain Mg_chelatase PF01078.16 CDF91574.1 - 1.2e-07 31.1 0.1 0.0025 16.9 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 CDF91574.1 - 1.3e-07 31.4 0.0 0.0012 18.5 0.0 3.2 4 0 0 4 4 2 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 CDF91574.1 - 2.1e-07 31.3 0.0 0.0046 17.2 0.0 2.8 2 1 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 CDF91574.1 - 2.3e-07 30.4 0.2 0.019 14.3 0.0 2.6 3 0 0 3 3 2 2 IstB-like ATP binding protein RuvB_N PF05496.7 CDF91574.1 - 9.7e-07 28.0 0.1 0.037 13.0 0.0 2.8 3 0 0 3 3 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 CDF91574.1 - 1.4e-06 28.1 0.0 0.0095 15.8 0.0 3.0 3 1 0 3 3 2 2 AAA domain AAA_2 PF07724.9 CDF91574.1 - 1.7e-05 24.8 0.0 0.0013 18.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) ABC_tran PF00005.22 CDF91574.1 - 2.6e-05 24.5 0.2 0.031 14.5 0.0 2.5 2 0 0 2 2 2 1 ABC transporter RNA_helicase PF00910.17 CDF91574.1 - 3.8e-05 23.7 0.0 0.24 11.5 0.0 3.0 2 0 0 2 2 2 2 RNA helicase PhoH PF02562.11 CDF91574.1 - 6e-05 22.3 0.0 0.08 12.1 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_11 PF13086.1 CDF91574.1 - 7.1e-05 22.4 0.0 0.1 12.1 0.0 2.3 2 0 0 2 2 2 2 AAA domain NACHT PF05729.7 CDF91574.1 - 7.4e-05 22.4 2.6 0.056 13.0 0.0 3.8 4 1 1 5 5 4 1 NACHT domain Sigma54_activat PF00158.21 CDF91574.1 - 7.7e-05 22.2 0.0 0.18 11.2 0.0 2.3 2 0 0 2 2 2 2 Sigma-54 interaction domain Zeta_toxin PF06414.7 CDF91574.1 - 8.6e-05 21.7 0.1 0.094 11.7 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin AAA_10 PF12846.2 CDF91574.1 - 9.8e-05 21.9 0.1 0.0077 15.7 0.0 2.3 2 0 0 2 2 2 1 AAA-like domain DUF2075 PF09848.4 CDF91574.1 - 0.00022 20.3 0.0 0.34 9.8 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) NB-ARC PF00931.17 CDF91574.1 - 0.00055 18.8 0.0 0.31 9.8 0.0 2.7 2 0 0 2 2 2 1 NB-ARC domain AAA_3 PF07726.6 CDF91574.1 - 0.00061 19.3 0.0 0.15 11.6 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.1 CDF91574.1 - 0.00065 19.3 2.7 0.69 9.4 0.1 2.9 2 1 0 2 2 2 2 AAA domain KaiC PF06745.8 CDF91574.1 - 0.0011 18.1 0.6 0.27 10.3 0.0 2.9 3 0 0 3 3 3 1 KaiC Sigma54_activ_2 PF14532.1 CDF91574.1 - 0.0011 19.0 0.3 2.6 8.0 0.1 3.5 2 1 1 3 3 2 1 Sigma-54 interaction domain AAA_28 PF13521.1 CDF91574.1 - 0.0014 18.6 0.0 2 8.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 CDF91574.1 - 0.0014 18.0 6.9 0.18 11.2 0.1 3.8 2 2 1 4 4 4 1 AAA domain DEAD PF00270.24 CDF91574.1 - 0.0026 17.2 0.3 13 5.2 0.0 3.9 3 1 1 4 4 4 0 DEAD/DEAH box helicase AAA_30 PF13604.1 CDF91574.1 - 0.0042 16.6 0.0 2.8 7.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain ResIII PF04851.10 CDF91574.1 - 0.0047 16.7 0.0 1.1 9.0 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UPF0079 PF02367.12 CDF91574.1 - 0.0055 16.3 0.1 1.7 8.2 0.0 2.8 3 0 0 3 3 3 1 Uncharacterised P-loop hydrolase UPF0079 T2SE PF00437.15 CDF91574.1 - 0.011 14.5 0.0 1.7 7.4 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein Arch_ATPase PF01637.13 CDF91574.1 - 0.012 15.3 0.6 3.4 7.3 0.0 3.1 2 1 1 3 3 3 0 Archaeal ATPase KTI12 PF08433.5 CDF91574.1 - 0.013 14.7 0.0 1.1 8.4 0.0 2.3 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Bac_DnaA PF00308.13 CDF91574.1 - 0.015 14.9 0.0 1.4 8.5 0.0 2.9 3 0 0 3 3 3 0 Bacterial dnaA protein AAA_29 PF13555.1 CDF91574.1 - 0.019 14.4 0.3 0.83 9.2 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.1 CDF91574.1 - 0.021 15.1 1.9 0.86 9.8 0.0 2.8 2 1 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.12 CDF91574.1 - 0.025 13.4 0.0 6.5 5.5 0.0 2.2 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 NTPase_1 PF03266.10 CDF91574.1 - 0.042 13.5 0.1 7.1 6.3 0.0 2.6 2 0 0 2 2 2 0 NTPase cobW PF02492.14 CDF91574.1 - 0.08 12.3 1.5 4.6 6.6 0.0 3.2 3 1 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Zot PF05707.7 CDF91574.1 - 0.093 12.1 0.0 5.3 6.4 0.0 2.7 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) Viral_helicase1 PF01443.13 CDF91574.1 - 0.13 11.7 0.0 1.1 8.6 0.0 2.1 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase FtsK_SpoIIIE PF01580.13 CDF91574.1 - 0.14 11.6 0.6 1.1 8.7 0.0 2.4 3 0 0 3 3 3 0 FtsK/SpoIIIE family IPT PF01745.11 CDF91574.1 - 0.16 11.1 0.1 2 7.4 0.0 2.2 2 0 0 2 2 2 0 Isopentenyl transferase PCI PF01399.22 CDF91575.1 - 1.7e-06 28.2 2.3 6.1e-06 26.5 0.1 2.8 3 0 0 3 3 3 1 PCI domain LRR_8 PF13855.1 CDF91576.1 - 0.0011 18.6 0.9 0.0011 18.6 0.6 4.1 4 2 1 5 5 5 1 Leucine rich repeat LRR_4 PF12799.2 CDF91576.1 - 0.0083 15.7 0.5 0.0083 15.7 0.3 4.3 5 2 0 5 5 5 1 Leucine Rich repeats (2 copies) LRR_9 PF14580.1 CDF91576.1 - 0.026 14.0 0.2 0.051 13.1 0.1 1.5 1 0 0 1 1 1 0 Leucine-rich repeat DUF4339 PF14237.1 CDF91576.1 - 0.11 12.1 0.0 0.28 10.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4339) Bacteriocin_IIc PF10439.4 CDF91576.1 - 0.45 10.6 7.5 7.8 6.7 0.1 3.7 2 1 1 3 3 3 0 Bacteriocin class II with double-glycine leader peptide DUF2201_N PF13203.1 CDF91576.1 - 4.2 6.4 6.0 6 5.9 4.1 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain Amidase PF01425.16 CDF91577.1 - 3e-77 260.3 0.0 3.8e-77 260.0 0.0 1.1 1 0 0 1 1 1 1 Amidase UQ_con PF00179.21 CDF91578.1 - 9.7e-45 151.4 0.0 1.3e-44 151.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 CDF91578.1 - 0.0055 16.5 0.0 0.01 15.7 0.0 1.6 1 1 0 1 1 1 1 RWD domain Prok-E2_B PF14461.1 CDF91578.1 - 0.012 15.3 0.0 0.043 13.5 0.0 1.8 1 1 0 1 1 1 0 Prokaryotic E2 family B SDA1 PF05285.7 CDF91578.1 - 4.9 6.3 19.0 6.8 5.8 13.1 1.2 1 0 0 1 1 1 0 SDA1 Dfp1_Him1_M PF08630.5 CDF91580.1 - 5.2e-46 155.4 0.4 4.2e-45 152.5 0.1 2.5 2 0 0 2 2 2 1 Dfp1/Him1, central region zf-DBF PF07535.7 CDF91580.1 - 3.9e-22 77.6 1.6 3.9e-22 77.6 1.1 2.0 2 0 0 2 2 2 1 DBF zinc finger Maf PF02545.9 CDF91580.1 - 0.026 13.6 1.5 0.034 13.2 0.2 1.8 2 0 0 2 2 2 0 Maf-like protein Fungal_trans_2 PF11951.3 CDF91581.1 - 1.4e-06 27.1 0.2 3.4e-06 25.9 0.0 1.7 1 1 1 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF91581.1 - 0.00023 21.0 14.3 0.00046 20.0 9.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lysis_col PF02402.11 CDF91581.1 - 0.13 11.9 0.0 0.28 10.8 0.0 1.5 1 0 0 1 1 1 0 Lysis protein Dickkopf_N PF04706.7 CDF91581.1 - 3.8 7.7 17.4 0.73 10.0 9.2 1.9 2 0 0 2 2 2 0 Dickkopf N-terminal cysteine-rich region TPR_11 PF13414.1 CDF91582.1 - 1.4e-14 53.4 4.6 0.00033 20.2 0.0 5.7 4 2 1 5 5 5 3 TPR repeat TPR_1 PF00515.23 CDF91582.1 - 3.6e-10 38.9 0.6 0.05 13.2 0.0 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.12 CDF91582.1 - 7.6e-10 37.9 0.8 0.6 10.1 0.0 6.8 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_17 PF13431.1 CDF91582.1 - 8.5e-07 28.6 0.7 0.054 13.7 0.0 4.2 4 0 0 4 4 3 2 Tetratricopeptide repeat Apc3 PF12895.2 CDF91582.1 - 1.1e-05 25.4 4.7 1.7 8.8 0.0 4.8 4 1 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.1 CDF91582.1 - 0.00019 21.7 0.9 0.042 14.1 0.0 3.7 5 0 0 5 5 2 1 Tetratricopeptide repeat TPR_7 PF13176.1 CDF91582.1 - 0.0017 18.0 0.6 0.37 10.7 0.0 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.1 CDF91582.1 - 0.0018 17.9 1.0 0.13 12.1 0.0 4.2 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_9 PF13371.1 CDF91582.1 - 0.0022 17.7 1.8 16 5.4 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 CDF91582.1 - 0.003 17.4 10.6 2.3 8.2 0.1 5.5 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.1 CDF91582.1 - 0.0061 17.1 9.1 0.27 11.9 0.0 5.8 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.1 CDF91582.1 - 0.0088 16.6 12.4 1.2 9.8 0.1 5.2 5 1 0 5 5 5 2 Tetratricopeptide repeat ChAPs PF09295.5 CDF91582.1 - 0.012 14.3 0.3 0.089 11.5 0.0 2.3 3 0 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) GP40 PF11025.3 CDF91582.1 - 0.65 9.5 5.4 1.4 8.4 3.7 1.5 1 0 0 1 1 1 0 Glycoprotein GP40 of Cryptosporidium Peptidase_M28 PF04389.12 CDF91583.1 - 5.8e-32 110.8 0.0 1.1e-31 109.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.23 CDF91583.1 - 0.0013 18.2 0.0 0.0016 17.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.9 CDF91583.1 - 0.0093 14.7 0.0 0.037 12.7 0.0 1.8 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase URO-D PF01208.12 CDF91584.1 - 8.7e-124 412.8 0.0 9.8e-124 412.7 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Ank_5 PF13857.1 CDF91585.1 - 0.00033 20.7 0.2 0.00099 19.2 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.2 CDF91585.1 - 0.0025 18.1 0.1 0.007 16.6 0.0 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.25 CDF91585.1 - 0.034 13.9 0.1 0.46 10.3 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeat SNF2_N PF00176.18 CDF91586.1 - 1.5e-64 217.6 0.0 2.2e-64 217.1 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CDF91586.1 - 1.4e-11 44.1 0.0 3.2e-11 42.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.3 CDF91586.1 - 1.6e-11 43.5 3.3 2.4e-10 39.7 2.3 2.3 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.24 CDF91586.1 - 1.5e-09 37.5 0.0 4.1e-09 36.1 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.10 CDF91586.1 - 4.6e-07 29.8 0.0 1.8e-06 27.9 0.0 2.1 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit DUF2439 PF10382.4 CDF91586.1 - 0.0036 17.4 0.0 0.011 15.9 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) ODR4-like PF14778.1 CDF91587.1 - 0.03 13.0 0.2 0.043 12.5 0.1 1.1 1 0 0 1 1 1 0 Olfactory receptor 4-like Alg14 PF08660.6 CDF91588.1 - 3.8e-51 173.4 0.4 5.5e-51 172.9 0.3 1.2 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like TIM PF00121.13 CDF91589.1 - 7.1e-90 300.3 0.0 8e-90 300.1 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase His_Phos_1 PF00300.17 CDF91590.1 - 2.2e-36 125.3 0.1 2.8e-36 125.0 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AA_permease PF00324.16 CDF91592.1 - 2e-118 395.8 33.3 2.4e-118 395.4 23.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CDF91592.1 - 1.1e-35 123.0 32.7 1.3e-35 122.7 22.7 1.1 1 0 0 1 1 1 1 Amino acid permease Bot1p PF12298.3 CDF91593.1 - 2e-60 203.6 0.0 2.9e-60 203.1 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein Sad1_UNC PF07738.8 CDF91594.1 - 2.7e-05 23.9 0.0 0.0012 18.5 0.0 2.5 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal Baculo_PEP_C PF04513.7 CDF91594.1 - 0.024 14.4 0.5 0.076 12.8 0.3 1.9 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2407_C PF13373.1 CDF91594.1 - 0.15 11.9 3.1 0.33 10.8 0.8 2.4 1 1 1 2 2 2 0 DUF2407 C-terminal domain Cpn60_TCP1 PF00118.19 CDF91596.1 - 8.2e-152 506.2 0.8 9.4e-152 506.0 0.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Mad3_BUB1_I PF08311.7 CDF91597.1 - 1.9e-43 147.2 0.2 5.1e-43 145.8 0.1 1.7 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Mad3_BUB1_II PF08171.6 CDF91597.1 - 6.2e-26 90.0 0.3 2.2e-25 88.3 0.0 2.1 2 0 0 2 2 2 1 Mad3/BUB1 homology region 2 Pkinase PF00069.20 CDF91597.1 - 1.9e-20 73.1 0.0 3.6e-20 72.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF91597.1 - 9.6e-06 24.8 0.0 1.8e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase VTC PF09359.5 CDF91598.1 - 3e-104 348.0 0.1 5e-104 347.2 0.0 1.3 1 0 0 1 1 1 1 VTC domain SPX PF03105.14 CDF91598.1 - 3.1e-23 82.9 12.6 3.1e-10 40.2 2.0 4.5 2 2 1 3 3 3 2 SPX domain DUF202 PF02656.10 CDF91598.1 - 1.3e-08 34.8 7.2 1.3e-08 34.8 5.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF202) LXG PF04740.7 CDF91598.1 - 0.0082 15.9 4.4 4.6 6.9 0.0 3.2 2 1 0 3 3 3 2 LXG domain of WXG superfamily RNA_pol_Rpb4 PF03874.11 CDF91599.1 - 1.1e-31 109.2 3.1 1.4e-31 108.9 2.2 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 Erf4 PF10256.4 CDF91599.1 - 0.034 13.9 0.1 0.06 13.2 0.1 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family Gemini_C4 PF01492.12 CDF91599.1 - 0.052 13.2 2.6 0.14 11.8 0.4 2.2 1 1 1 2 2 2 0 Geminivirus C4 protein PilN PF05137.8 CDF91599.1 - 0.13 12.0 0.7 1.8 8.4 0.0 2.3 2 1 0 2 2 2 0 Fimbrial assembly protein (PilN) Glyco_hydro_16 PF00722.16 CDF91600.1 - 1.1e-44 151.9 3.2 1.1e-44 151.9 2.3 2.3 2 1 0 2 2 2 1 Glycosyl hydrolases family 16 Lin-8 PF03353.10 CDF91600.1 - 6.8 5.8 10.9 9.8 5.3 7.6 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist MmoB_DmpM PF02406.12 CDF91601.1 - 0.036 14.0 0.0 0.06 13.3 0.0 1.3 1 0 0 1 1 1 0 MmoB/DmpM family AA_permease PF00324.16 CDF91602.1 - 1.5e-136 455.5 32.2 1.9e-136 455.2 22.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CDF91602.1 - 1.3e-36 126.1 35.4 1.5e-36 125.8 24.5 1.0 1 0 0 1 1 1 1 Amino acid permease Rap_GAP PF02145.10 CDF91603.1 - 1.6e-42 145.0 0.5 2.9e-42 144.1 0.3 1.5 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.11 CDF91603.1 - 3.2e-11 42.8 0.0 6.6e-11 41.8 0.0 1.5 1 0 0 1 1 1 1 Tuberin DUF3384 PF11864.3 CDF91603.1 - 2.7e-07 29.4 0.9 4.8e-07 28.6 0.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3384) Ric8 PF10165.4 CDF91603.1 - 0.13 11.0 2.2 5.7 5.6 0.1 2.5 2 0 0 2 2 2 0 Guanine nucleotide exchange factor synembryn EIF_2_alpha PF07541.7 CDF91604.1 - 1.2e-41 141.0 0.5 3.5e-41 139.4 0.1 1.9 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.18 CDF91604.1 - 1.3e-14 54.0 1.2 3.2e-14 52.7 0.9 1.7 1 0 0 1 1 1 1 S1 RNA binding domain Mpp10 PF04006.7 CDF91604.1 - 0.0056 15.1 2.8 0.0081 14.5 1.9 1.2 1 0 0 1 1 1 1 Mpp10 protein EXOSC1 PF10447.4 CDF91604.1 - 0.059 13.3 0.5 0.15 12.0 0.3 1.8 1 1 0 1 1 1 0 Exosome component EXOSC1/CSL4 Memo PF01875.12 CDF91605.1 - 1.2e-90 303.0 0.0 1.5e-90 302.8 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein Caudo_TAP PF02413.12 CDF91605.1 - 0.12 12.5 0.1 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Caudovirales tail fibre assembly protein PUA PF01472.15 CDF91607.1 - 1.6e-20 72.6 0.0 2.8e-20 71.8 0.0 1.4 1 0 0 1 1 1 1 PUA domain DUF1947 PF09183.5 CDF91607.1 - 0.0043 16.7 0.9 0.0074 16.0 0.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1947) CAP_GLY PF01302.20 CDF91608.1 - 2e-16 59.4 0.2 3.4e-16 58.6 0.1 1.3 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.2 CDF91608.1 - 2.3e-11 43.0 29.1 0.003 17.1 1.3 6.0 5 2 1 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.1 CDF91608.1 - 7.6e-07 28.8 27.0 0.0012 18.5 1.8 4.9 2 1 3 5 5 5 4 Leucine rich repeat LRR_1 PF00560.28 CDF91608.1 - 2.1e-05 23.8 32.7 1.3 9.3 0.0 9.6 9 1 1 10 10 10 3 Leucine Rich Repeat LRR_6 PF13516.1 CDF91608.1 - 0.0015 18.3 33.5 2.2 8.5 0.1 9.6 8 2 1 9 9 9 3 Leucine Rich repeat LRR_7 PF13504.1 CDF91608.1 - 0.0021 17.9 20.5 11 6.6 0.0 9.0 8 1 0 8 8 8 2 Leucine rich repeat GN3L_Grn1 PF08701.6 CDF91609.1 - 2.2e-23 81.9 16.9 6.9e-23 80.3 11.7 1.9 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.18 CDF91609.1 - 4.1e-21 75.1 0.1 6.9e-15 55.0 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.13 CDF91609.1 - 1.2e-07 31.1 0.1 1.6e-06 27.4 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 CDF91609.1 - 2e-05 24.0 0.0 0.018 14.4 0.0 2.5 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.11 CDF91609.1 - 0.00012 21.2 0.1 0.00042 19.4 0.0 1.9 2 0 0 2 2 2 1 AIG1 family DUF258 PF03193.11 CDF91609.1 - 0.00014 21.0 0.2 0.00026 20.2 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 CDF91609.1 - 0.00038 20.3 9.5 0.14 11.9 0.2 3.8 2 2 1 3 3 3 2 Dynamin family Miro PF08477.8 CDF91609.1 - 0.0011 19.4 0.6 0.073 13.5 0.0 2.9 2 1 1 3 3 3 1 Miro-like protein cobW PF02492.14 CDF91609.1 - 0.0033 16.8 0.2 1.4 8.3 0.0 2.5 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.9 CDF91609.1 - 0.015 15.0 0.6 0.17 11.5 0.1 2.8 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B ArgK PF03308.11 CDF91609.1 - 0.018 13.8 0.0 0.043 12.6 0.0 1.6 1 0 0 1 1 1 0 ArgK protein GDA1_CD39 PF01150.12 CDF91610.1 - 5.2e-147 489.8 0.0 6.5e-147 489.5 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.11 CDF91610.1 - 0.045 12.9 0.0 0.086 12.0 0.0 1.5 1 0 0 1 1 1 0 Ppx/GppA phosphatase family HIM1 PF08732.5 CDF91611.1 - 5.8e-12 44.7 0.4 9.7e-08 30.8 0.0 3.1 1 1 1 2 2 2 2 HIM1 NAD_binding_10 PF13460.1 CDF91611.1 - 2.7e-10 40.5 0.0 3.6e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 CDF91611.1 - 6e-05 22.5 0.0 0.00013 21.5 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.8 CDF91611.1 - 0.00026 20.3 0.0 0.00096 18.4 0.0 2.0 1 1 0 1 1 1 1 NmrA-like family PMI_typeI PF01238.16 CDF91612.1 - 5.5e-151 502.7 0.0 6.3e-151 502.5 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.14 CDF91612.1 - 0.0012 18.5 0.0 0.28 10.8 0.0 2.6 2 0 0 2 2 2 2 AraC-like ligand binding domain Cupin_2 PF07883.6 CDF91612.1 - 0.028 13.8 0.0 2.2 7.8 0.0 2.4 2 0 0 2 2 2 0 Cupin domain Nop16 PF09420.5 CDF91613.1 - 8.2e-60 201.6 6.8 9.5e-60 201.4 4.7 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 RRM_1 PF00076.17 CDF91614.1 - 2.7e-20 71.7 0.0 4.7e-20 71.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF91614.1 - 1.1e-17 63.7 0.0 1.7e-17 63.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF91614.1 - 3.5e-10 39.5 0.0 8.5e-10 38.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.8 CDF91614.1 - 0.11 12.2 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.1 CDF91614.1 - 0.13 12.0 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif BTB PF00651.26 CDF91616.1 - 6.8e-21 74.3 0.5 1.5e-15 57.1 0.2 2.6 2 0 0 2 2 2 2 BTB/POZ domain Ank_2 PF12796.2 CDF91616.1 - 4.1e-08 33.4 0.0 2e-07 31.2 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.25 CDF91616.1 - 1.6e-07 30.7 0.5 1.9e-06 27.3 0.0 2.7 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.1 CDF91616.1 - 0.00043 20.2 0.1 0.021 15.0 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.1 CDF91616.1 - 0.00088 19.7 0.0 0.0032 17.9 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.1 CDF91616.1 - 0.0054 16.9 0.1 0.023 14.9 0.0 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Syja_N PF02383.13 CDF91617.1 - 3.2e-62 210.1 0.2 5.2e-62 209.4 0.2 1.3 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.18 CDF91617.1 - 9.4e-21 74.8 0.0 1.8e-20 73.9 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DDOST_48kD PF03345.9 CDF91619.1 - 5e-124 414.0 0.7 5.9e-124 413.8 0.5 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Prefoldin_2 PF01920.15 CDF91620.1 - 1.1e-17 63.6 8.3 1.2e-17 63.5 5.7 1.0 1 0 0 1 1 1 1 Prefoldin subunit RVT_3 PF13456.1 CDF91620.1 - 0.036 13.8 0.4 0.075 12.8 0.2 1.6 1 1 0 1 1 1 0 Reverse transcriptase-like adh_short_C2 PF13561.1 CDF91620.1 - 0.04 13.6 1.1 0.046 13.4 0.7 1.0 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Ribosomal_L25p PF01386.14 CDF91620.1 - 0.056 13.5 0.7 0.1 12.6 0.1 1.7 2 0 0 2 2 2 0 Ribosomal L25p family DUF2935 PF11155.3 CDF91620.1 - 0.059 13.4 0.8 0.083 12.9 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) bZIP_1 PF00170.16 CDF91620.1 - 0.14 12.1 5.1 0.27 11.2 1.3 2.1 2 0 0 2 2 2 0 bZIP transcription factor IncA PF04156.9 CDF91620.1 - 0.26 10.8 3.1 0.45 10.0 2.1 1.4 1 1 0 1 1 1 0 IncA protein DUF904 PF06005.7 CDF91620.1 - 0.62 10.4 4.3 2.8 8.3 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF904) Occludin_ELL PF07303.8 CDF91620.1 - 0.9 10.3 6.1 5.7 7.7 0.3 2.1 1 1 1 2 2 2 0 Occludin homology domain Tropomyosin PF00261.15 CDF91621.1 - 0.0085 15.2 0.2 0.0085 15.2 0.1 1.4 2 0 0 2 2 2 1 Tropomyosin ParA PF10609.4 CDF91622.1 - 6.6e-37 125.2 0.0 1e-36 124.6 0.0 1.3 1 0 0 1 1 1 1 ParA/MinD ATPase like CbiA PF01656.18 CDF91622.1 - 6.1e-16 58.4 0.0 8.4e-16 57.9 0.0 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.6 CDF91622.1 - 2.4e-06 26.8 0.0 1.7e-05 24.0 0.0 1.9 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.10 CDF91622.1 - 8.6e-06 25.0 0.1 3.8e-05 22.9 0.1 1.8 2 0 0 2 2 2 1 Anion-transporting ATPase AAA_31 PF13614.1 CDF91622.1 - 4.7e-05 23.3 0.0 0.00019 21.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain zf-C4_ClpX PF06689.8 CDF91622.1 - 0.0034 16.8 1.7 0.0074 15.7 1.2 1.5 1 0 0 1 1 1 1 ClpX C4-type zinc finger AAA_25 PF13481.1 CDF91622.1 - 0.031 13.6 0.1 0.051 12.9 0.1 1.2 1 0 0 1 1 1 0 AAA domain YhjQ PF06564.7 CDF91622.1 - 0.034 13.4 0.0 0.06 12.6 0.0 1.4 1 1 0 1 1 1 0 YhjQ protein ArgK PF03308.11 CDF91622.1 - 0.06 12.1 0.1 0.088 11.5 0.0 1.2 1 0 0 1 1 1 0 ArgK protein APS_kinase PF01583.15 CDF91622.1 - 0.11 12.1 0.0 0.29 10.7 0.0 1.7 2 0 0 2 2 2 0 Adenylylsulphate kinase SNARE PF05739.14 CDF91623.1 - 4.6e-09 35.8 1.2 6.9e-09 35.2 0.8 1.3 1 0 0 1 1 1 1 SNARE domain Use1 PF09753.4 CDF91623.1 - 0.0048 16.3 2.1 0.0074 15.7 1.4 1.5 1 1 0 1 1 1 1 Membrane fusion protein Use1 AIP3 PF03915.8 CDF91623.1 - 0.11 11.3 0.7 0.13 11.1 0.5 1.0 1 0 0 1 1 1 0 Actin interacting protein 3 Synaptobrevin PF00957.16 CDF91623.1 - 1.4 8.5 5.5 3 7.4 3.8 1.6 1 1 0 1 1 1 0 Synaptobrevin Thioredoxin PF00085.15 CDF91624.1 - 2.6e-18 65.6 0.3 3.9e-15 55.4 0.0 3.8 3 1 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.1 CDF91624.1 - 1.6e-06 28.0 1.7 6.6e-05 22.7 0.1 2.7 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_4 PF13462.1 CDF91624.1 - 0.00015 21.8 0.0 0.0005 20.1 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_8 PF13905.1 CDF91624.1 - 0.0011 18.9 0.1 0.0065 16.5 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin-like Mito_carr PF00153.22 CDF91625.1 - 8e-72 237.0 0.7 2.9e-25 87.7 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF2759 PF10958.3 CDF91625.1 - 0.093 12.3 0.1 0.2 11.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2759) Pox_D3 PF04580.8 CDF91625.1 - 0.15 11.1 0.1 2 7.5 0.0 2.3 1 1 1 2 2 2 0 Chordopoxvirinae D3 protein Gti1_Pac2 PF09729.4 CDF91626.1 - 7.8e-47 159.2 0.0 2e-46 157.9 0.0 1.7 1 1 0 1 1 1 1 Gti1/Pac2 family bZIP_1 PF00170.16 CDF91627.1 - 3.2e-13 49.4 9.0 5e-13 48.8 6.2 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.10 CDF91627.1 - 4.9e-13 48.6 10.3 7.8e-13 48.0 7.1 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.12 CDF91627.1 - 0.0032 17.7 5.2 0.0058 16.9 3.6 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor Gly-rich_Ago1 PF12764.2 CDF91627.1 - 0.018 15.6 0.1 0.043 14.4 0.1 1.6 1 0 0 1 1 1 0 Glycine-rich region of argonaut DUF972 PF06156.8 CDF91627.1 - 0.041 14.2 1.4 0.083 13.2 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF972) TSC22 PF01166.13 CDF91627.1 - 0.047 13.6 2.9 0.084 12.8 1.3 1.8 2 0 0 2 2 2 0 TSC-22/dip/bun family DivIC PF04977.10 CDF91627.1 - 2.1 7.8 5.7 1.1 8.7 2.6 1.6 1 1 1 2 2 2 0 Septum formation initiator Inp1 PF12634.2 CDF91628.1 - 1.5e-30 105.7 0.0 2.5e-28 98.5 0.0 2.2 1 1 1 2 2 2 2 Inheritance of peroxisomes protein 1 PFK PF00365.15 CDF91629.1 - 9.2e-166 549.7 0.7 4.8e-123 409.6 1.1 2.2 2 0 0 2 2 2 2 Phosphofructokinase Peptidase_M19 PF01244.16 CDF91630.1 - 2.7e-105 351.8 0.0 3.1e-105 351.6 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Amidohydro_2 PF04909.9 CDF91630.1 - 0.055 13.0 0.0 0.11 12.0 0.0 1.6 2 0 0 2 2 2 0 Amidohydrolase PHP PF02811.14 CDF91630.1 - 0.076 12.8 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 PHP domain Glyoxalase PF00903.20 CDF91632.1 - 3.3e-34 117.6 0.3 1.9e-18 66.6 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 CDF91632.1 - 4.3e-28 98.0 0.0 4.5e-13 49.7 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_4 PF13669.1 CDF91632.1 - 2.7e-14 53.1 0.0 5.9e-08 32.6 0.0 3.1 2 2 1 3 3 3 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.1 CDF91632.1 - 3.6e-05 23.7 0.0 0.055 13.3 0.0 2.9 2 1 0 2 2 2 2 Glyoxalase-like domain HA2 PF04408.18 CDF91633.1 - 5.1e-18 64.9 0.0 3.2e-17 62.4 0.0 2.3 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.11 CDF91633.1 - 1.5e-16 60.2 0.0 3.5e-16 59.0 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.26 CDF91633.1 - 5.6e-12 45.3 0.0 1.6e-11 43.9 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 CDF91633.1 - 1.4e-07 31.1 0.9 3.5e-07 29.8 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase T2SE PF00437.15 CDF91633.1 - 4.7e-05 22.4 0.0 0.00011 21.2 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.1 CDF91633.1 - 4.9e-05 23.4 0.1 0.00015 21.9 0.1 1.9 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.9 CDF91633.1 - 0.0047 16.7 0.0 0.0096 15.6 0.0 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain ResIII PF04851.10 CDF91633.1 - 0.014 15.2 0.0 1.2 8.8 0.0 2.8 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_30 PF13604.1 CDF91633.1 - 0.049 13.2 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 CDF91633.1 - 0.049 13.3 0.4 0.12 12.1 0.3 1.6 1 0 0 1 1 1 0 Part of AAA domain FtsK_SpoIIIE PF01580.13 CDF91633.1 - 0.077 12.4 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family ABC_tran PF00005.22 CDF91633.1 - 0.16 12.3 7.6 0.57 10.4 0.0 3.2 3 0 0 3 3 3 0 ABC transporter AAA_11 PF13086.1 CDF91633.1 - 1.1 8.7 4.7 1.7 8.1 0.0 2.8 3 0 0 3 3 3 0 AAA domain PRK PF00485.13 CDF91634.1 - 2e-60 203.7 0.0 2.9e-60 203.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.1 CDF91634.1 - 1.2e-32 112.8 0.4 2e-32 112.1 0.3 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_17 PF13207.1 CDF91634.1 - 1.5e-10 41.9 0.0 4.4e-10 40.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CDF91634.1 - 8.4e-06 26.1 0.0 3.3e-05 24.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 CDF91634.1 - 0.00022 21.1 0.0 0.0019 18.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 CDF91634.1 - 0.0013 17.8 0.0 0.0027 16.8 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.1 CDF91634.1 - 0.022 14.8 0.1 0.11 12.6 0.0 2.1 3 0 0 3 3 3 0 AAA domain CPT PF07931.7 CDF91634.1 - 0.024 14.2 0.0 0.053 13.1 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_24 PF13479.1 CDF91634.1 - 0.038 13.5 0.0 0.11 12.0 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.1 CDF91634.1 - 0.065 13.2 0.0 0.17 11.8 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain CoaE PF01121.15 CDF91634.1 - 0.066 12.6 0.3 18 4.6 0.0 3.2 3 0 0 3 3 3 0 Dephospho-CoA kinase AAA PF00004.24 CDF91634.1 - 0.073 13.2 0.0 0.35 11.0 0.0 2.2 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.1 CDF91634.1 - 0.074 12.8 0.1 0.2 11.4 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain SPX PF03105.14 CDF91635.1 - 1.6e-51 175.7 1.4 3e-51 174.8 1.0 1.5 1 0 0 1 1 1 1 SPX domain Na_sulph_symp PF00939.14 CDF91635.1 - 1.4e-20 73.6 42.9 2e-20 73.1 29.7 1.2 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.11 CDF91635.1 - 2e-13 49.6 44.4 1.4e-10 40.2 13.9 2.3 1 1 1 2 2 2 2 Citrate transporter Tom22 PF04281.8 CDF91635.1 - 0.0014 18.1 0.5 0.13 11.8 0.0 2.7 2 0 0 2 2 2 1 Mitochondrial import receptor subunit Tom22 MFS_1 PF07690.11 CDF91639.1 - 3e-50 170.9 20.3 3e-50 170.9 14.1 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily ESSS PF10183.4 CDF91639.1 - 0.0033 17.7 0.1 0.012 16.0 0.0 1.9 2 0 0 2 2 2 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) FUN14 PF04930.10 CDF91639.1 - 0.28 11.4 3.0 1.1 9.5 2.1 2.0 1 0 0 1 1 1 0 FUN14 family Abi PF02517.11 CDF91639.1 - 2.3 8.4 12.7 15 5.8 5.7 3.1 2 1 0 2 2 2 0 CAAX protease self-immunity MFS_1 PF07690.11 CDF91643.1 - 1.2e-33 116.3 30.6 1.2e-33 116.3 21.2 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.8 CDF91643.1 - 0.0013 17.0 3.7 0.0019 16.4 2.5 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.15 CDF91643.1 - 0.0027 15.8 2.9 0.0027 15.8 2.0 2.7 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.11 CDF91647.1 - 1.5e-30 106.1 16.9 2.1e-30 105.6 11.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Amidase PF01425.16 CDF91648.1 - 2e-82 277.4 0.0 2.3e-82 277.1 0.0 1.1 1 0 0 1 1 1 1 Amidase MFS_1 PF07690.11 CDF91650.1 - 3.8e-17 62.0 42.4 1.7e-16 59.9 29.4 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily CGI-121 PF08617.5 CDF91651.1 - 0.76 9.4 9.7 6.5 6.4 2.4 3.0 3 0 0 3 3 3 0 Kinase binding protein CGI-121 Cys_Met_Meta_PP PF01053.15 CDF91653.1 - 7e-82 274.7 0.0 8.5e-82 274.4 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 CDF91653.1 - 0.0024 16.6 0.0 0.0033 16.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 CDF91653.1 - 0.013 14.6 0.0 0.03 13.4 0.0 1.5 1 1 0 1 1 1 0 Beta-eliminating lyase Fungal_trans PF04082.13 CDF91654.1 - 1.1e-14 53.9 3.2 2.1e-14 53.0 2.2 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF91654.1 - 2.1e-05 24.3 12.4 5.5e-05 22.9 8.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hydantoinase_B PF02538.9 CDF91655.1 - 2.2e-216 719.1 0.4 2.9e-216 718.8 0.3 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.13 CDF91655.1 - 2.6e-90 302.4 0.1 1.5e-89 299.9 0.0 2.2 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 CDF91655.1 - 1.1e-54 184.6 0.2 8.2e-52 175.2 0.0 3.3 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase N-terminal region MFS_1 PF07690.11 CDF91656.1 - 1.2e-37 129.5 27.1 1.4e-37 129.2 18.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Epiglycanin_C PF14654.1 CDF91656.1 - 0.091 12.7 0.9 1.3 9.0 0.0 2.6 2 0 0 2 2 2 0 Mucin, catalytic, TM and cytoplasmic tail region DUF2818 PF10993.3 CDF91656.1 - 0.3 11.6 3.5 32 5.1 0.5 3.5 1 1 3 4 4 4 0 Protein of unknown function (DUF2818) DUF2427 PF10348.4 CDF91656.1 - 6.9 6.3 11.9 3.1 7.4 1.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF2427) Flo11 PF10182.4 CDF91657.1 - 2.7e-31 108.2 0.4 4.3e-31 107.5 0.3 1.3 1 0 0 1 1 1 1 Flo11 domain Fungal_trans_2 PF11951.3 CDF91658.1 - 2.6e-47 161.2 7.9 7.2e-47 159.7 5.5 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF91658.1 - 1e-07 31.7 8.3 2.3e-07 30.5 5.8 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1484 PF07363.6 CDF91658.1 - 0.5 10.7 3.3 0.98 9.7 1.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1484) Aminotran_4 PF01063.14 CDF91659.1 - 4.5e-28 98.2 0.0 5.5e-28 97.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class IV 5-FTHF_cyc-lig PF01812.15 CDF91660.1 - 1.2e-45 155.6 0.1 1.4e-45 155.4 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family SET PF00856.23 CDF91662.1 - 3.7e-12 46.8 0.0 8.5e-12 45.6 0.0 1.7 1 1 0 1 1 1 1 SET domain DUF581 PF04570.9 CDF91662.1 - 0.49 9.7 8.9 1.2 8.4 0.6 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF581) HSF_DNA-bind PF00447.12 CDF91663.1 - 3.4e-34 117.1 1.8 8e-34 115.9 1.2 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding Response_reg PF00072.19 CDF91663.1 - 8.6e-26 90.1 0.3 1.6e-25 89.2 0.2 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Pkinase PF00069.20 CDF91664.1 - 1.1e-68 231.2 0.0 1.9e-68 230.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF91664.1 - 1.4e-30 106.2 0.0 2.4e-30 105.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.19 CDF91664.1 - 2.5e-11 43.8 2.2 2.5e-11 43.8 1.5 2.3 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.1 CDF91664.1 - 2.2e-08 33.3 0.0 4.6e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Kinase-like C2 PF00168.25 CDF91664.1 - 6.5e-07 29.1 0.0 1e-05 25.2 0.0 2.4 1 1 0 1 1 1 1 C2 domain YrbL-PhoP_reg PF10707.4 CDF91664.1 - 0.33 10.2 0.0 0.33 10.2 0.0 2.5 3 0 0 3 3 3 0 PhoP regulatory network protein YrbL Glyco_hydro_47 PF01532.15 CDF91665.1 - 2.5e-122 408.8 0.4 4.5e-122 407.9 0.3 1.4 2 0 0 2 2 2 1 Glycosyl hydrolase family 47 DUF2593 PF10767.4 CDF91665.1 - 0.17 11.5 0.0 0.4 10.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2593) Ribosomal_S4e PF00900.15 CDF91666.1 - 2e-32 110.6 1.1 6.7e-32 108.9 0.5 1.9 2 0 0 2 2 2 1 Ribosomal family S4e RS4NT PF08071.7 CDF91666.1 - 1.4e-19 69.6 5.4 3.2e-19 68.4 3.7 1.7 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.20 CDF91666.1 - 8.9e-09 34.6 0.0 2.1e-08 33.4 0.0 1.7 1 0 0 1 1 1 1 S4 domain KOW PF00467.24 CDF91666.1 - 0.00038 20.0 0.8 0.00038 20.0 0.5 3.3 4 0 0 4 4 4 1 KOW motif Metallophos PF00149.23 CDF91667.1 - 4.4e-08 32.7 9.6 1.6e-07 30.9 6.7 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase DSPn PF14671.1 CDF91668.1 - 4.2e-50 169.3 0.0 1.2e-49 167.9 0.0 1.7 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.15 CDF91668.1 - 5e-24 84.3 0.0 1.5e-22 79.6 0.0 2.3 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.22 CDF91668.1 - 2.7e-05 23.6 0.0 4.7e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.7 CDF91668.1 - 0.00069 19.1 0.2 0.0013 18.2 0.1 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.1 CDF91668.1 - 0.0094 16.0 0.0 0.026 14.5 0.0 1.7 2 0 0 2 2 2 1 Inositol hexakisphosphate Acetyltransf_13 PF13880.1 CDF91669.1 - 3.1e-19 68.4 0.1 6.5e-19 67.4 0.1 1.5 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.1 CDF91669.1 - 8.4e-12 44.4 0.8 1.4e-11 43.7 0.6 1.4 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_1 PF00583.19 CDF91669.1 - 0.03 14.3 0.0 0.07 13.1 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family PHP PF02811.14 CDF91670.1 - 1.4e-19 70.5 0.0 2.7e-19 69.6 0.0 1.4 1 1 0 1 1 1 1 PHP domain ProRS-C_1 PF09180.6 CDF91671.1 - 2.8e-25 88.0 1.2 6.8e-25 86.7 0.8 1.7 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.20 CDF91671.1 - 3.3e-23 82.1 0.0 5.1e-23 81.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 CDF91671.1 - 1.1e-19 70.1 0.2 2.3e-19 69.0 0.1 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA_edit PF04073.10 CDF91671.1 - 0.021 14.6 0.0 0.042 13.6 0.0 1.4 1 0 0 1 1 1 0 Aminoacyl-tRNA editing domain tRNA-synt_2 PF00152.15 CDF91672.1 - 1.6e-72 244.1 0.0 2.7e-72 243.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 CDF91672.1 - 1.1e-12 47.6 0.0 2.2e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Ins134_P3_kin PF05770.6 CDF91672.1 - 0.0065 15.5 0.0 0.012 14.6 0.0 1.4 1 0 0 1 1 1 1 Inositol 1, 3, 4-trisphosphate 5/6-kinase Lyase_1 PF00206.15 CDF91673.1 - 7.8e-96 320.9 0.0 1.1e-95 320.4 0.0 1.2 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.1 CDF91673.1 - 2.5e-24 85.1 0.0 6.1e-24 83.8 0.0 1.7 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal DUF1776 PF08643.5 CDF91674.1 - 2.4e-51 174.6 0.4 3.5e-51 174.1 0.3 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) MFS_1_like PF12832.2 CDF91674.1 - 0.0049 16.6 0.1 0.013 15.3 0.1 1.7 1 0 0 1 1 1 1 MFS_1 like family DUF4496 PF14908.1 CDF91674.1 - 0.075 12.9 0.0 0.18 11.6 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4496) DUP PF00674.13 CDF91675.1 - 3.1e-08 33.5 0.2 3.1e-08 33.5 0.2 2.0 2 0 0 2 2 2 1 DUP family Mpv17_PMP22 PF04117.7 CDF91675.1 - 0.022 14.3 0.1 0.06 12.9 0.1 1.7 1 0 0 1 1 1 0 Mpv17 / PMP22 family RRM_1 PF00076.17 CDF91677.1 - 7e-42 140.9 6.6 6.1e-15 54.6 0.0 4.6 4 1 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF91677.1 - 1.5e-26 92.1 0.2 3.5e-07 30.1 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF91677.1 - 6.9e-17 61.0 2.8 3.3e-06 26.8 0.4 3.8 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.1 CDF91677.1 - 0.081 12.7 0.3 3.1 7.6 0.0 3.0 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Pyr_redox_2 PF07992.9 CDF91678.1 - 8.1e-21 74.8 0.0 2.1e-20 73.4 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 CDF91678.1 - 7.5e-16 58.3 0.1 3.2e-10 40.2 0.0 3.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CDF91678.1 - 0.082 12.9 0.1 37 4.4 0.1 3.3 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CDF91678.1 - 0.13 12.2 0.0 8.5 6.3 0.0 2.9 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase NAP PF00956.13 CDF91679.1 - 1.9e-14 53.3 5.8 3.8e-11 42.5 2.1 2.1 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) Arrestin_C PF02752.17 CDF91680.1 - 3.1e-20 72.6 0.0 6.5e-20 71.6 0.0 1.6 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.24 CDF91680.1 - 6.9e-10 38.9 0.0 3.1e-06 27.0 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.2 CDF91680.1 - 0.0044 16.5 0.0 0.01 15.3 0.0 1.5 1 0 0 1 1 1 1 Arrestin_N terminal like WD40 PF00400.27 CDF91681.1 - 3.1e-07 30.0 0.0 0.0035 17.1 0.0 2.8 2 0 0 2 2 2 2 WD domain, G-beta repeat PIP5K PF01504.13 CDF91682.1 - 3.4e-65 219.6 1.3 3.4e-65 219.6 0.9 2.5 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.19 CDF91682.1 - 3.3e-24 85.3 0.1 6.1e-24 84.4 0.0 1.4 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.16 CDF91682.1 - 4.6e-17 61.6 9.9 4.6e-17 61.6 6.9 1.8 2 0 0 2 2 2 1 FYVE zinc finger IBR PF01485.16 CDF91682.1 - 1.2 9.0 8.4 0.39 10.6 3.3 2.1 2 0 0 2 2 2 0 IBR domain DZR PF12773.2 CDF91682.1 - 4.7 7.1 10.4 49 3.8 0.0 3.1 2 1 0 2 2 2 0 Double zinc ribbon Peptidase_M28 PF04389.12 CDF91683.1 - 1.8e-36 125.5 0.1 2.5e-36 125.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 TIP120 PF08623.5 CDF91684.1 - 0.0019 17.7 0.0 0.004 16.7 0.0 1.5 1 0 0 1 1 1 1 TATA-binding protein interacting (TIP20) HrpJ PF07201.6 CDF91684.1 - 1.5 8.7 13.8 0.17 11.8 0.4 3.1 3 0 0 3 3 3 0 HrpJ-like domain DUF3646 PF12362.3 CDF91685.1 - 0.099 12.5 0.9 0.18 11.7 0.6 1.4 1 0 0 1 1 1 0 DNA polymerase III gamma and tau subunits C terminal GTP_EFTU PF00009.22 CDF91686.1 - 6.3e-33 113.7 4.9 5.2e-32 110.8 3.4 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 CDF91686.1 - 4.1e-24 84.5 0.0 1.1e-23 83.1 0.0 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.20 CDF91686.1 - 9e-09 35.3 3.3 0.0027 17.7 0.0 3.7 3 0 0 3 3 3 2 Elongation factor Tu domain 2 IF2_N PF04760.10 CDF91686.1 - 3.7e-07 29.6 0.0 1.8e-06 27.4 0.0 2.2 2 0 0 2 2 2 1 Translation initiation factor IF-2, N-terminal region MMR_HSR1 PF01926.18 CDF91686.1 - 8.9e-07 28.8 0.2 2.1e-06 27.6 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 CDF91686.1 - 1.7e-05 25.2 0.4 3.6e-05 24.2 0.3 1.6 1 0 0 1 1 1 1 Miro-like protein Dynamin_N PF00350.18 CDF91686.1 - 0.0011 18.8 0.9 1 9.1 0.1 2.9 2 1 1 3 3 3 2 Dynamin family Ras PF00071.17 CDF91686.1 - 0.0013 18.0 0.0 0.0047 16.3 0.0 2.0 2 0 0 2 2 2 1 Ras family SRPRB PF09439.5 CDF91686.1 - 0.0014 17.8 0.1 0.0029 16.8 0.0 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.13 CDF91686.1 - 0.0075 15.5 1.2 0.2 10.9 0.2 2.9 2 1 0 2 2 2 1 Ferrous iron transport protein B MobB PF03205.9 CDF91686.1 - 0.09 12.4 2.0 0.77 9.4 0.2 2.8 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B PDCD2_C PF04194.8 CDF91687.1 - 5.5e-39 133.3 0.9 1.7e-38 131.7 0.0 2.2 2 1 1 3 3 3 1 Programmed cell death protein 2, C-terminal putative domain PHD PF00628.24 CDF91687.1 - 0.12 12.1 0.3 3.4 7.4 0.0 2.4 2 0 0 2 2 2 0 PHD-finger ABC_tran PF00005.22 CDF91688.1 - 1.5e-46 158.1 2.4 4.2e-23 82.1 0.0 3.5 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.1 CDF91688.1 - 6.2e-20 72.3 8.2 9.1e-07 29.1 0.1 4.8 3 2 1 4 4 4 3 AAA domain ABC_tran_2 PF12848.2 CDF91688.1 - 3.7e-19 68.3 10.1 3.7e-19 68.3 7.0 3.5 5 0 0 5 5 2 1 ABC transporter SMC_N PF02463.14 CDF91688.1 - 1.7e-10 40.5 0.1 0.0021 17.3 0.1 3.7 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 CDF91688.1 - 5.3e-10 40.1 3.1 0.00077 20.2 0.0 3.5 5 0 0 5 5 2 2 AAA domain AAA_15 PF13175.1 CDF91688.1 - 2.8e-08 33.2 12.9 0.011 14.7 0.0 5.4 3 2 1 6 6 6 3 AAA ATPase domain AAA_18 PF13238.1 CDF91688.1 - 1.2e-07 32.1 7.0 0.0031 17.8 0.0 4.8 5 1 1 6 6 4 2 AAA domain AAA_16 PF13191.1 CDF91688.1 - 5.1e-07 29.8 1.4 0.0077 16.2 0.1 3.1 3 0 0 3 3 3 2 AAA ATPase domain AAA_28 PF13521.1 CDF91688.1 - 8.1e-07 29.1 0.0 0.014 15.3 0.0 3.2 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.1 CDF91688.1 - 1.7e-06 28.2 0.6 0.12 12.5 0.0 3.6 3 1 0 3 3 3 2 AAA domain NACHT PF05729.7 CDF91688.1 - 1.8e-06 27.7 0.1 0.011 15.4 0.0 2.5 2 0 0 2 2 2 2 NACHT domain DUF258 PF03193.11 CDF91688.1 - 3.7e-06 26.2 0.0 0.043 12.9 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function, DUF258 Miro PF08477.8 CDF91688.1 - 5.4e-06 26.8 0.0 0.21 12.0 0.0 2.8 2 0 0 2 2 2 2 Miro-like protein AAA_14 PF13173.1 CDF91688.1 - 9e-06 25.6 0.0 0.094 12.6 0.0 3.4 3 0 0 3 3 2 2 AAA domain AAA PF00004.24 CDF91688.1 - 1.7e-05 25.0 0.0 0.036 14.2 0.0 3.4 4 1 0 4 4 2 1 ATPase family associated with various cellular activities (AAA) MobB PF03205.9 CDF91688.1 - 2.6e-05 23.9 0.0 0.075 12.7 0.1 2.8 2 0 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B AAA_29 PF13555.1 CDF91688.1 - 3.2e-05 23.3 5.2 0.071 12.6 0.0 3.0 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_33 PF13671.1 CDF91688.1 - 7e-05 22.7 1.6 0.11 12.3 0.0 3.7 4 1 0 4 4 3 1 AAA domain RNA_helicase PF00910.17 CDF91688.1 - 7.2e-05 22.9 0.4 0.21 11.7 0.0 3.5 4 0 0 4 4 3 1 RNA helicase MMR_HSR1 PF01926.18 CDF91688.1 - 7.4e-05 22.6 0.1 0.14 12.1 0.0 3.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.1 CDF91688.1 - 0.00013 22.4 24.2 0.27 11.5 0.0 5.2 5 0 0 5 5 5 2 AAA domain PduV-EutP PF10662.4 CDF91688.1 - 0.00014 21.3 3.0 0.09 12.2 0.1 3.2 4 0 0 4 4 3 2 Ethanolamine utilisation - propanediol utilisation SbcCD_C PF13558.1 CDF91688.1 - 0.00037 20.3 0.1 1.4 8.8 0.0 3.3 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit NB-ARC PF00931.17 CDF91688.1 - 0.00071 18.5 0.4 0.93 8.2 0.0 2.9 3 0 0 3 3 3 2 NB-ARC domain ATP-synt_ab PF00006.20 CDF91688.1 - 0.00076 19.0 0.0 0.28 10.6 0.0 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_5 PF07728.9 CDF91688.1 - 0.0014 18.4 4.4 2.8 7.6 0.1 3.6 4 0 0 4 4 3 1 AAA domain (dynein-related subfamily) Pox_A32 PF04665.7 CDF91688.1 - 0.0022 17.3 0.1 0.054 12.7 0.0 2.6 2 0 0 2 2 2 1 Poxvirus A32 protein ArgK PF03308.11 CDF91688.1 - 0.0048 15.7 0.2 0.54 8.9 0.0 2.8 3 0 0 3 3 3 1 ArgK protein AAA_25 PF13481.1 CDF91688.1 - 0.0052 16.2 0.0 3.7 6.9 0.0 2.8 2 1 0 2 2 2 0 AAA domain T2SE PF00437.15 CDF91688.1 - 0.0066 15.3 0.0 0.079 11.8 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein cobW PF02492.14 CDF91688.1 - 0.0067 15.8 0.0 1.8 7.9 0.0 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.13 CDF91688.1 - 0.012 14.6 0.4 3.8 6.4 0.0 2.7 3 0 0 3 3 2 0 Septin NTPase_1 PF03266.10 CDF91688.1 - 0.013 15.2 0.0 2.2 7.9 0.0 2.6 2 0 0 2 2 2 0 NTPase AAA_10 PF12846.2 CDF91688.1 - 0.014 14.8 2.5 3.4 7.0 0.1 3.2 3 2 0 3 3 2 0 AAA-like domain FeoB_N PF02421.13 CDF91688.1 - 0.014 14.6 0.0 3.6 6.8 0.0 2.7 2 0 0 2 2 2 0 Ferrous iron transport protein B Arch_ATPase PF01637.13 CDF91688.1 - 0.021 14.5 3.4 1.3 8.6 0.0 3.4 4 0 0 4 4 3 0 Archaeal ATPase AAA_24 PF13479.1 CDF91688.1 - 0.027 14.0 0.0 8.8 5.8 0.0 2.9 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.17 CDF91688.1 - 0.033 13.6 0.1 1.7 8.0 0.1 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain FtsK_SpoIIIE PF01580.13 CDF91688.1 - 0.042 13.3 0.6 4.8 6.6 0.0 3.3 4 0 0 4 4 4 0 FtsK/SpoIIIE family Ras PF00071.17 CDF91688.1 - 0.069 12.5 0.4 11 5.4 0.0 3.1 3 0 0 3 3 3 0 Ras family DUF721 PF05258.7 CDF91688.1 - 0.12 12.5 0.7 0.72 10.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF721) DUF2813 PF11398.3 CDF91688.1 - 0.17 10.9 0.0 0.17 10.9 0.0 3.5 3 1 0 4 4 4 0 Protein of unknown function (DUF2813) Mg_chelatase PF01078.16 CDF91688.1 - 0.18 10.9 0.9 5.6 6.0 0.0 2.9 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI Dynamin_N PF00350.18 CDF91688.1 - 0.66 9.7 11.9 7.6 6.3 3.3 3.8 3 2 0 3 3 2 0 Dynamin family RNB PF00773.14 CDF91689.1 - 2.1e-92 309.9 0.0 3.2e-92 309.2 0.0 1.2 1 0 0 1 1 1 1 RNB domain PIN_4 PF13638.1 CDF91689.1 - 6.2e-15 55.4 0.3 1.7e-14 54.0 0.2 1.7 1 0 0 1 1 1 1 PIN domain OB_RNB PF08206.6 CDF91689.1 - 0.011 15.1 0.0 0.041 13.3 0.0 1.9 1 0 0 1 1 1 0 Ribonuclease B OB domain DUF736 PF05284.7 CDF91689.1 - 0.15 11.8 0.0 0.78 9.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF736) Aminotran_1_2 PF00155.16 CDF91690.1 - 3.4e-46 157.8 0.0 4.8e-46 157.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 CDF91690.1 - 5.4e-09 35.6 0.0 1.2e-08 34.4 0.0 1.5 2 0 0 2 2 2 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 CDF91690.1 - 1.2e-07 30.4 0.0 1.5e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 CDF91690.1 - 3.4e-06 26.0 0.0 5.1e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.12 CDF91690.1 - 0.0013 17.8 0.1 0.0026 16.8 0.1 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family UCH PF00443.24 CDF91691.1 - 1.6e-51 175.0 3.6 1.9e-51 174.7 2.5 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CDF91691.1 - 6.3e-20 71.7 10.9 1.3e-19 70.7 7.6 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.18 CDF91691.1 - 1.4e-06 27.6 0.0 4.1e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin family DUF1690 PF07956.6 CDF91692.1 - 2.1e-41 141.2 11.3 2.4e-41 141.0 7.9 1.0 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) Nup84_Nup100 PF04121.8 CDF91692.1 - 0.00065 17.5 0.6 0.00081 17.2 0.4 1.1 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 Pneumo_phosprot PF02478.11 CDF91692.1 - 0.011 15.2 8.3 0.014 14.9 5.7 1.1 1 0 0 1 1 1 0 Pneumovirus phosphoprotein Osteopontin PF00865.13 CDF91692.1 - 0.018 14.2 6.4 0.022 14.0 4.4 1.1 1 0 0 1 1 1 0 Osteopontin Myb_DNA-bind_4 PF13837.1 CDF91692.1 - 0.062 13.4 0.8 0.12 12.5 0.6 1.6 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain Ret_tiss PF10044.4 CDF91692.1 - 0.11 13.1 0.4 0.16 12.5 0.3 1.4 1 0 0 1 1 1 0 Retinal tissue protein DUF342 PF03961.8 CDF91692.1 - 0.22 9.8 3.0 0.25 9.7 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF342) XhlA PF10779.4 CDF91692.1 - 0.37 10.7 5.4 25 4.8 0.0 2.3 1 1 1 2 2 2 0 Haemolysin XhlA DUF4316 PF14195.1 CDF91692.1 - 0.42 10.7 5.4 0.47 10.5 3.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4316) Laminin_II PF06009.7 CDF91692.1 - 0.95 9.2 5.9 1.2 8.9 3.4 1.6 1 1 0 1 1 1 0 Laminin Domain II Prefoldin_2 PF01920.15 CDF91692.1 - 1.2 8.8 13.4 76 3.1 6.9 2.4 2 1 0 2 2 2 0 Prefoldin subunit IncA PF04156.9 CDF91692.1 - 1.3 8.6 9.7 2 7.9 6.7 1.3 1 0 0 1 1 1 0 IncA protein DASH_Dad3 PF08656.5 CDF91692.1 - 3.1 7.5 8.3 2.4 7.9 0.4 2.6 2 1 1 3 3 3 0 DASH complex subunit Dad3 ARD PF03079.9 CDF91693.1 - 1.4e-41 142.0 0.8 1.6e-41 141.8 0.5 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.6 CDF91693.1 - 1.6e-07 30.6 0.0 2.4e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.14 CDF91693.1 - 0.0002 21.0 0.0 0.00035 20.2 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain PQ-loop PF04193.9 CDF91694.1 - 4.3e-13 48.6 10.9 9.4e-11 41.1 2.9 3.1 2 1 0 2 2 2 2 PQ loop repeat Pet127 PF08634.5 CDF91695.1 - 1.8e-104 348.7 9.3 6.1e-103 343.7 6.4 2.2 1 1 0 1 1 1 1 Mitochondrial protein Pet127 TauD PF02668.11 CDF91696.1 - 2.6e-53 181.3 0.0 7e-53 179.9 0.0 1.6 2 0 0 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.5 CDF91696.1 - 0.021 13.7 0.0 0.091 11.6 0.0 1.8 2 0 0 2 2 2 0 CsiD TP6A_N PF04406.9 CDF91697.1 - 6.4e-14 51.3 0.1 1.3e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase EMP24_GP25L PF01105.19 CDF91698.1 - 3.6e-36 124.5 0.0 4.2e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD FUN14 PF04930.10 CDF91699.1 - 1.7e-06 28.2 1.0 3.4e-06 27.2 0.7 1.5 1 1 0 1 1 1 1 FUN14 family DUF3477 PF11963.3 CDF91699.1 - 0.12 11.3 0.0 0.16 10.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3477) B56 PF01603.15 CDF91700.1 - 1.1e-143 478.8 16.7 1.5e-138 461.8 7.8 2.3 3 0 0 3 3 3 2 Protein phosphatase 2A regulatory B subunit (B56 family) Rab15_effector PF15208.1 CDF91701.1 - 0.16 11.3 0.1 11 5.3 0.1 2.2 1 1 1 2 2 2 0 Rab15 effector AA_permease_2 PF13520.1 CDF91702.1 - 1.4e-66 224.7 39.0 1.8e-66 224.4 27.0 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 CDF91702.1 - 9.4e-26 90.1 33.5 1.4e-25 89.5 23.2 1.2 1 1 0 1 1 1 1 Amino acid permease DUF3185 PF11381.3 CDF91702.1 - 0.48 10.2 6.4 0.57 9.9 2.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) DUF2207 PF09972.4 CDF91702.1 - 0.71 8.3 9.1 0.39 9.2 0.4 3.2 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) Spo7 PF03907.8 CDF91703.1 - 4.1e-87 291.1 6.3 4.7e-87 290.9 4.3 1.0 1 0 0 1 1 1 1 Spo7-like protein DUF2207 PF09972.4 CDF91703.1 - 0.068 11.7 0.3 0.085 11.4 0.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3722 PF12519.3 CDF91704.1 - 8.5e-79 264.4 12.4 8.5e-79 264.4 8.6 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3722) EspF PF04806.7 CDF91705.1 - 0.017 15.2 1.8 0.042 14.0 1.3 1.6 1 0 0 1 1 1 0 EspF protein repeat SMC_N PF02463.14 CDF91706.1 - 3.9e-16 58.9 38.3 2.2e-15 56.4 26.5 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 CDF91706.1 - 1.2e-10 42.1 98.8 1.6e-10 41.6 35.5 5.7 2 2 0 2 2 2 1 AAA domain AAA_21 PF13304.1 CDF91706.1 - 3.3e-07 30.5 2.5 3.3e-07 30.5 1.7 4.5 3 2 1 4 4 4 1 AAA domain AAA_29 PF13555.1 CDF91706.1 - 2.7e-05 23.6 0.0 5.2e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain MutS_V PF00488.16 CDF91706.1 - 0.018 14.4 0.4 0.23 10.8 0.0 2.8 3 0 0 3 3 3 0 MutS domain V AAA_25 PF13481.1 CDF91706.1 - 0.022 14.1 3.6 0.035 13.5 0.0 3.1 4 0 0 4 4 4 0 AAA domain AAA_33 PF13671.1 CDF91706.1 - 0.031 14.1 0.0 0.27 11.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain Baculo_PEP_C PF04513.7 CDF91706.1 - 0.34 10.7 0.0 0.34 10.7 0.0 5.2 5 1 1 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus GAS PF13851.1 CDF91706.1 - 1.8 7.7 94.1 0.025 13.7 8.2 4.5 2 2 1 4 4 4 0 Growth-arrest specific micro-tubule binding UCH PF00443.24 CDF91707.1 - 1.7e-61 207.6 1.3 3.2e-61 206.7 0.9 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.1 CDF91707.1 - 7.9e-48 159.7 4.9 5.1e-21 73.8 0.2 5.0 4 0 0 4 4 4 4 A repeated domain in UCH-protein UCH_1 PF13423.1 CDF91707.1 - 5.4e-10 39.2 2.3 0.00037 20.0 0.2 2.9 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase EF-hand_1 PF00036.27 CDF91708.1 - 5.9e-26 87.7 4.5 3.6e-08 32.1 0.1 4.5 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.1 CDF91708.1 - 3.4e-23 79.3 2.1 9.5e-07 28.1 0.0 4.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.1 CDF91708.1 - 3.1e-22 78.4 9.5 9.1e-14 51.3 0.7 3.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.1 CDF91708.1 - 2e-19 68.9 3.5 5.5e-09 35.5 0.0 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.1 CDF91708.1 - 4.8e-19 66.7 8.5 8.7e-06 24.8 0.1 4.7 5 1 0 5 5 5 3 EF hand EF-hand_4 PF12763.2 CDF91708.1 - 0.00014 21.5 4.3 0.61 9.8 0.1 3.4 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.1 CDF91708.1 - 0.00023 20.9 0.1 0.0044 16.9 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain S10_plectin PF03501.10 CDF91708.1 - 0.00048 19.9 0.0 0.00082 19.1 0.0 1.5 1 0 0 1 1 1 1 Plectin/S10 domain SPARC_Ca_bdg PF10591.4 CDF91708.1 - 0.0023 17.9 0.7 0.11 12.5 0.1 3.0 2 2 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.1 CDF91708.1 - 0.0073 15.9 0.1 3.1 7.5 0.0 3.0 3 0 0 3 3 3 1 EF hand COQ7 PF03232.8 CDF91709.1 - 5.4e-75 250.5 0.0 6.5e-75 250.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 YTH PF04146.10 CDF91710.1 - 1.9e-39 134.4 0.0 3.1e-39 133.7 0.0 1.3 1 0 0 1 1 1 1 YT521-B-like domain DUF1903 PF08991.5 CDF91711.1 - 0.071 13.2 0.3 0.087 12.9 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1903) BCS1_N PF08740.6 CDF91712.1 - 1.1e-49 168.5 0.0 2.1e-49 167.7 0.0 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.24 CDF91712.1 - 6.9e-23 81.2 0.0 1.9e-22 79.8 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 CDF91712.1 - 2e-05 25.4 0.0 3.9e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDF91712.1 - 0.0016 18.4 0.0 0.0053 16.7 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.1 CDF91712.1 - 0.0019 18.1 0.0 0.0041 17.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CDF91712.1 - 0.0021 18.1 0.0 0.0054 16.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 CDF91712.1 - 0.004 17.4 0.0 0.015 15.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.1 CDF91712.1 - 0.0046 16.9 0.1 0.016 15.2 0.1 1.7 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.7 CDF91712.1 - 0.0046 16.0 0.0 0.0079 15.2 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_25 PF13481.1 CDF91712.1 - 0.0047 16.3 0.0 0.0088 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 CDF91712.1 - 0.0093 15.0 0.0 0.016 14.3 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_14 PF13173.1 CDF91712.1 - 0.016 15.1 0.0 0.035 14.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 CDF91712.1 - 0.016 14.8 0.0 0.042 13.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.1 CDF91712.1 - 0.019 14.5 0.1 0.046 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.1 CDF91712.1 - 0.022 14.2 0.0 0.06 12.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.22 CDF91712.1 - 0.03 14.6 0.0 0.066 13.5 0.0 1.6 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.7 CDF91712.1 - 0.032 13.8 0.0 0.27 10.8 0.0 2.4 2 1 1 3 3 3 0 NACHT domain DUF815 PF05673.8 CDF91712.1 - 0.035 13.0 0.0 0.054 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RNA_helicase PF00910.17 CDF91712.1 - 0.035 14.2 0.0 0.13 12.4 0.0 2.0 2 0 0 2 2 1 0 RNA helicase AAA_19 PF13245.1 CDF91712.1 - 0.05 13.3 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 Part of AAA domain Arch_ATPase PF01637.13 CDF91712.1 - 0.056 13.1 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Archaeal ATPase KaiC PF06745.8 CDF91712.1 - 0.056 12.5 0.0 0.1 11.6 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_28 PF13521.1 CDF91712.1 - 0.076 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.1 CDF91712.1 - 0.095 13.0 0.0 0.26 11.5 0.0 1.6 2 0 0 2 2 1 0 AAA domain Miro PF08477.8 CDF91712.1 - 0.096 13.1 0.0 0.25 11.8 0.0 1.7 1 0 0 1 1 1 0 Miro-like protein Lipase_GDSL_2 PF13472.1 CDF91713.1 - 2.9e-20 73.1 0.0 3.5e-20 72.8 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.17 CDF91713.1 - 8.2e-19 68.3 0.1 1e-18 68.0 0.1 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Pyr_redox_3 PF13738.1 CDF91714.1 - 2.6e-05 24.3 0.0 0.037 14.0 0.0 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 CDF91714.1 - 5.5e-05 23.1 0.0 0.0011 18.8 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 CDF91714.1 - 0.00011 22.1 0.0 0.00025 20.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.1 CDF91714.1 - 0.00059 19.6 0.0 0.0043 16.8 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.19 CDF91714.1 - 0.0011 17.9 0.0 0.032 13.0 0.1 2.3 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.22 CDF91714.1 - 0.048 14.0 0.3 2.2 8.7 0.1 3.3 3 1 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase F1F0-ATPsyn_F PF10791.4 CDF91715.1 - 2.6e-43 146.1 0.2 2.9e-43 146.0 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi WRW PF10206.4 CDF91715.1 - 0.018 15.0 0.0 0.035 14.1 0.0 1.5 1 1 1 2 2 2 0 Mitochondrial F1F0-ATP synthase, subunit f LSM PF01423.17 CDF91716.1 - 1.1e-15 56.9 0.0 1.3e-15 56.7 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 CDF91716.1 - 2e-05 24.4 0.1 2.4e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain RhoGAP PF00620.22 CDF91717.1 - 2e-43 147.5 1.0 3.7e-43 146.7 0.1 1.9 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.17 CDF91717.1 - 8.8e-12 44.9 29.3 4.2e-06 26.7 8.5 2.8 3 0 0 3 3 3 2 LIM domain Complex1_LYR PF05347.10 CDF91718.1 - 1.1e-13 50.7 0.2 1.4e-13 50.4 0.2 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.1 CDF91718.1 - 6.7e-12 45.4 0.4 8.2e-12 45.1 0.3 1.1 1 0 0 1 1 1 1 Complex1_LYR-like AIRC PF00731.15 CDF91719.1 - 4.6e-66 220.7 0.8 7.8e-66 219.9 0.6 1.4 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.17 CDF91719.1 - 2.1e-61 206.2 0.0 3.4e-61 205.5 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.1 CDF91719.1 - 1.7e-06 27.8 0.0 3.4e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain 2-Hacid_dh_C PF02826.14 CDF91719.1 - 0.00042 19.5 0.0 0.00083 18.5 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CPSase_L_D2 PF02786.12 CDF91719.1 - 0.0033 16.7 0.0 0.0055 16.0 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.8 CDF91719.1 - 0.0066 15.8 0.0 0.047 13.0 0.0 2.2 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus CoA_binding_2 PF13380.1 CDF91719.1 - 0.014 15.5 2.3 1.6 8.9 0.0 3.3 3 1 1 4 4 4 0 CoA binding domain XdhC_C PF13478.1 CDF91719.1 - 0.067 13.5 0.1 1.3 9.3 0.0 2.7 2 1 1 3 3 3 0 XdhC Rossmann domain ATPgrasp_Ter PF15632.1 CDF91719.1 - 0.071 11.8 0.0 4 6.0 0.0 2.6 3 0 0 3 3 3 0 ATP-grasp in the biosynthetic pathway with Ter operon Shikimate_DH PF01488.15 CDF91719.1 - 0.084 12.9 2.6 0.23 11.5 0.0 2.8 3 1 1 4 4 4 0 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.12 CDF91719.1 - 0.088 13.2 0.1 0.74 10.2 0.0 2.4 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent CPSase_L_chain PF00289.17 CDF91719.1 - 0.09 12.8 0.2 0.35 10.9 0.0 2.1 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, N-terminal domain TPP_enzyme_N PF02776.13 CDF91720.1 - 1.1e-26 93.3 0.0 1.7e-26 92.7 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.17 CDF91720.1 - 8.3e-16 57.9 0.0 1.5e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.16 CDF91720.1 - 1.5e-12 47.3 0.0 3.7e-12 46.0 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Rhabdo_ncap_2 PF03216.8 CDF91720.1 - 0.037 12.7 0.1 0.71 8.5 0.0 2.3 3 0 0 3 3 3 0 Rhabdovirus nucleoprotein Afi1 PF07792.7 CDF91721.1 - 9e-28 97.1 0.0 2.2e-27 95.8 0.0 1.7 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.5 CDF91721.1 - 1.1e-20 73.4 0.1 2.2e-20 72.4 0.0 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis SNARE PF05739.14 CDF91722.1 - 1.7e-18 66.0 6.8 1.2e-17 63.2 1.6 2.4 2 0 0 2 2 2 2 SNARE domain Syntaxin PF00804.20 CDF91722.1 - 3.4e-07 30.3 0.3 3.4e-07 30.3 0.2 2.5 1 1 1 2 2 2 1 Syntaxin DUF2408 PF10303.4 CDF91722.1 - 0.03 14.4 0.6 0.03 14.4 0.4 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2408) TMPIT PF07851.8 CDF91722.1 - 0.29 10.1 5.7 0.14 11.1 2.4 1.5 1 1 0 1 1 1 0 TMPIT-like protein SUR7 PF06687.7 CDF91723.1 - 1.3e-14 54.3 15.1 1.7e-14 53.9 10.5 1.1 1 0 0 1 1 1 1 SUR7/PalI family Glyco_hydro_72 PF03198.9 CDF91724.1 - 6.9e-141 468.7 7.6 9.5e-141 468.2 5.2 1.2 1 0 0 1 1 1 1 Glucanosyltransferase bZIP_1 PF00170.16 CDF91725.1 - 8.2e-06 25.6 14.8 6.2e-05 22.8 5.2 2.4 1 1 1 2 2 2 2 bZIP transcription factor Hap4_Hap_bind PF10297.4 CDF91725.1 - 4.5e-05 23.1 6.3 0.0001 22.0 4.3 1.6 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 FlaC_arch PF05377.6 CDF91725.1 - 0.0038 17.0 1.5 0.12 12.2 1.0 2.4 1 1 0 1 1 1 1 Flagella accessory protein C (FlaC) DUF812 PF05667.6 CDF91725.1 - 0.029 12.9 6.7 0.053 12.0 4.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) bZIP_2 PF07716.10 CDF91725.1 - 0.063 13.1 17.2 0.11 12.3 5.6 2.3 1 1 1 2 2 2 0 Basic region leucine zipper Reo_sigmaC PF04582.7 CDF91725.1 - 0.13 11.4 2.0 0.18 10.9 0.2 1.8 1 1 0 2 2 2 0 Reovirus sigma C capsid protein DUF641 PF04859.7 CDF91725.1 - 0.16 11.6 5.3 0.37 10.5 3.7 1.6 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) GAS PF13851.1 CDF91725.1 - 0.17 11.0 9.0 0.3 10.2 6.2 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF4407 PF14362.1 CDF91725.1 - 0.2 10.5 1.8 0.27 10.1 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ADIP PF11559.3 CDF91725.1 - 0.23 11.3 12.6 0.39 10.6 8.7 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF724 PF05266.9 CDF91725.1 - 0.63 9.6 9.6 1.2 8.7 6.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) bZIP_Maf PF03131.12 CDF91725.1 - 3 8.1 13.0 3.7e+02 1.4 9.0 2.4 1 1 0 1 1 1 0 bZIP Maf transcription factor IncA PF04156.9 CDF91725.1 - 4.6 6.7 10.7 8.8 5.8 7.4 1.4 1 0 0 1 1 1 0 IncA protein LETM1 PF07766.8 CDF91726.1 - 2.3e-103 344.9 3.5 4.3e-103 344.0 2.4 1.5 1 0 0 1 1 1 1 LETM1-like protein Rpr2 PF04032.11 CDF91728.1 - 3.9e-16 58.6 0.7 4.9e-16 58.3 0.5 1.2 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain TOM13 PF08219.6 CDF91729.1 - 5e-24 83.8 0.0 5.8e-24 83.6 0.0 1.0 1 0 0 1 1 1 1 Outer membrane protein TOM13 Proteasome PF00227.21 CDF91730.1 - 2.5e-56 189.9 0.0 3.4e-56 189.5 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 CDF91730.1 - 6e-13 47.8 0.1 1.2e-12 46.8 0.1 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Helicase_C_3 PF13625.1 CDF91730.1 - 0.08 12.7 0.0 0.44 10.2 0.0 2.2 3 0 0 3 3 3 0 Helicase conserved C-terminal domain bZIP_2 PF07716.10 CDF91732.1 - 1.7e-08 34.1 10.6 1.7e-08 34.1 7.4 2.6 2 1 1 3 3 3 1 Basic region leucine zipper DDHD PF02862.12 CDF91732.1 - 0.41 10.3 8.0 0.54 10.0 5.6 1.3 1 0 0 1 1 1 0 DDHD domain TCP PF03634.8 CDF91732.1 - 0.48 10.7 9.3 0.93 9.8 6.5 1.4 1 0 0 1 1 1 0 TCP family transcription factor bZIP_1 PF00170.16 CDF91732.1 - 0.57 10.1 23.5 0.21 11.5 12.7 2.8 3 1 0 3 3 3 0 bZIP transcription factor Adeno_PIX PF03955.9 CDF91732.1 - 1.9 9.0 6.2 0.76 10.3 0.5 2.3 1 1 1 2 2 2 0 Adenovirus hexon-associated protein (IX) SlyX PF04102.7 CDF91732.1 - 2.4 8.6 8.6 0.47 10.8 2.0 2.4 2 0 0 2 2 2 0 SlyX DivIC PF04977.10 CDF91732.1 - 8.6 5.9 15.0 1.2 8.6 4.0 2.7 2 1 0 2 2 2 0 Septum formation initiator Mannosyl_trans3 PF11051.3 CDF91733.1 - 6.7e-63 212.5 0.1 9.6e-63 212.0 0.1 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Methyltransf_6 PF03737.10 CDF91734.1 - 2.2e-33 115.2 0.0 2.7e-33 115.0 0.0 1.1 1 0 0 1 1 1 1 Demethylmenaquinone methyltransferase RRM_1 PF00076.17 CDF91735.1 - 3.4e-19 68.2 0.0 6.2e-19 67.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF91735.1 - 1.1e-12 47.7 0.0 1.6e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF91735.1 - 9.6e-08 31.7 0.0 2.4e-07 30.4 0.0 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1720 PF08226.6 CDF91736.1 - 2.3e-27 94.8 347.5 0.00071 19.5 14.8 15.1 3 2 4 7 7 7 4 Domain of unknown function (DUF1720) EF-hand_4 PF12763.2 CDF91736.1 - 1.2e-24 86.0 0.0 3.6e-12 45.9 0.0 2.4 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.27 CDF91736.1 - 1.7e-06 26.8 0.0 0.0018 17.4 0.0 3.3 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.1 CDF91736.1 - 3.2e-06 27.1 0.0 0.00069 19.7 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.1 CDF91736.1 - 0.00042 19.9 0.0 1 9.4 0.0 4.2 4 0 0 4 4 4 1 EF-hand domain Cwf_Cwc_15 PF04889.7 CDF91736.1 - 7.7 6.1 25.3 0.09 12.4 11.1 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Helicase_C PF00271.26 CDF91737.1 - 1.3e-20 73.0 0.3 8.4e-20 70.4 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 CDF91737.1 - 8.9e-20 70.8 0.1 4.7e-18 65.2 0.0 2.9 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.10 CDF91737.1 - 4.5e-17 62.4 0.0 4.5e-17 62.4 0.0 3.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit OmpH PF03938.9 CDF91737.1 - 0.00067 19.6 1.0 0.00067 19.6 0.7 1.8 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) eIF3_p135 PF12807.2 CDF91737.1 - 0.18 11.7 3.3 4.7 7.1 0.1 2.7 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit 135 Sec3_C PF09763.4 CDF91738.1 - 4.1e-146 487.9 18.3 4.1e-146 487.9 12.7 2.2 2 0 0 2 2 2 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.1 CDF91738.1 - 4.3e-26 90.5 0.4 1.1e-25 89.3 0.3 1.7 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Med15 PF09606.5 CDF91738.1 - 0.31 9.1 60.9 0.56 8.3 42.2 1.4 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal NTF2 PF02136.15 CDF91739.1 - 1.5e-35 122.1 0.2 1.6e-35 121.9 0.2 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4518 PF15008.1 CDF91739.1 - 0.00037 19.6 0.2 0.0006 18.9 0.1 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4518) DUF4440 PF14534.1 CDF91739.1 - 0.03 14.5 0.0 0.038 14.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Glyco_transf_52 PF07922.6 CDF91739.1 - 0.069 12.1 0.1 0.39 9.7 0.0 1.8 1 1 1 2 2 2 0 Glycosyltransferase family 52 DUF3210 PF11489.3 CDF91740.1 - 5.7e-18 64.9 29.8 5.7e-18 64.9 20.7 6.1 2 1 4 6 6 6 1 Protein of unknown function (DUF3210) Sec20 PF03908.8 CDF91740.1 - 0.21 11.3 4.2 0.27 10.9 0.3 2.8 2 0 0 2 2 2 0 Sec20 DnaJ-X PF14308.1 CDF91741.1 - 5.9e-63 211.8 3.5 5.9e-63 211.8 2.4 2.3 2 0 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.26 CDF91741.1 - 1.9e-25 88.3 0.9 6.6e-25 86.6 0.6 2.0 1 0 0 1 1 1 1 DnaJ domain SopA PF13981.1 CDF91741.1 - 0.025 14.6 0.0 0.074 13.0 0.0 1.8 1 0 0 1 1 1 0 SopA-like central domain RPT PF13446.1 CDF91741.1 - 0.04 13.3 0.1 0.38 10.1 0.0 2.5 2 0 0 2 2 2 0 A repeated domain in UCH-protein Ycf1 PF05758.7 CDF91741.1 - 0.32 8.6 13.7 0.56 7.8 9.5 1.4 1 0 0 1 1 1 0 Ycf1 DUF4407 PF14362.1 CDF91741.1 - 0.4 9.5 6.5 0.76 8.6 4.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DNA_pack_N PF02500.10 CDF91741.1 - 4.2 6.8 8.5 0.65 9.4 3.1 1.7 2 0 0 2 2 2 0 Probable DNA packing protein, N-terminus Snf7 PF03357.16 CDF91742.1 - 2.5e-29 101.8 4.8 3.1e-29 101.5 3.3 1.0 1 0 0 1 1 1 1 Snf7 TPR_19 PF14559.1 CDF91742.1 - 0.0079 16.5 0.7 0.094 13.0 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat Syntaxin PF00804.20 CDF91742.1 - 10 6.3 8.3 1.2 9.3 1.9 2.3 2 2 0 2 2 2 0 Syntaxin AAA PF00004.24 CDF91743.1 - 4.2e-12 46.4 0.0 9.8e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 CDF91743.1 - 6.5e-07 28.3 0.3 0.0016 17.1 0.1 2.7 2 1 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_17 PF13207.1 CDF91743.1 - 1.9e-05 25.4 0.0 0.0001 23.0 0.0 2.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 CDF91743.1 - 5.6e-05 23.2 0.1 0.00098 19.2 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.1 CDF91743.1 - 0.00073 19.5 0.0 0.0018 18.2 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.7 CDF91743.1 - 0.0015 17.6 0.0 0.0047 16.0 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_33 PF13671.1 CDF91743.1 - 0.0017 18.2 0.1 0.011 15.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.7 CDF91743.1 - 0.0084 15.2 0.0 0.02 13.9 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_14 PF13173.1 CDF91743.1 - 0.015 15.1 0.0 0.035 14.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.9 CDF91743.1 - 0.016 14.9 0.0 0.04 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.1 CDF91743.1 - 0.02 15.1 0.0 0.092 13.0 0.0 2.2 1 0 0 1 1 1 0 AAA domain DUF258 PF03193.11 CDF91743.1 - 0.025 13.7 0.0 0.053 12.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_19 PF13245.1 CDF91743.1 - 0.041 13.6 0.1 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain IPT PF01745.11 CDF91743.1 - 0.092 11.9 0.1 0.22 10.6 0.1 1.6 1 0 0 1 1 1 0 Isopentenyl transferase AAA_3 PF07726.6 CDF91743.1 - 0.14 11.8 0.0 1.1 8.8 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) CRAL_TRIO PF00650.15 CDF91744.1 - 9.5e-36 122.6 0.1 1.5e-35 122.0 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.10 CDF91744.1 - 2.1e-11 43.7 0.0 5.8e-11 42.3 0.0 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.1 CDF91744.1 - 0.0013 18.6 0.0 0.0024 17.7 0.0 1.4 1 1 0 1 1 1 1 Divergent CRAL/TRIO domain RasGAP PF00616.14 CDF91745.1 - 7.3e-48 162.8 3.6 7.7e-47 159.5 0.6 2.6 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase C2 PF00168.25 CDF91745.1 - 6.8e-06 25.8 0.0 1.4e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 C2 domain tRNA-synt_1c PF00749.16 CDF91745.1 - 0.067 11.8 0.2 0.25 9.9 0.0 1.9 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain UPF1_Zn_bind PF09416.5 CDF91746.1 - 1.4e-70 235.7 7.2 1.4e-70 235.7 5.0 2.1 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.1 CDF91746.1 - 5.3e-59 198.9 0.0 9e-59 198.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 CDF91746.1 - 2e-50 171.5 0.8 2e-50 171.5 0.6 1.7 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.1 CDF91746.1 - 9.9e-15 54.6 0.2 2e-13 50.3 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 CDF91746.1 - 7.7e-14 51.2 0.1 3.1e-13 49.2 0.1 2.0 2 0 0 2 2 2 1 Part of AAA domain ResIII PF04851.10 CDF91746.1 - 2.5e-05 24.1 0.0 5.9e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.13 CDF91746.1 - 5e-05 22.9 0.0 0.13 11.7 0.0 2.8 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.4 CDF91746.1 - 5.5e-05 22.3 0.4 0.00041 19.4 0.0 2.6 3 1 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.9 CDF91746.1 - 0.0028 17.3 0.0 0.0053 16.4 0.0 1.5 1 0 0 1 1 1 1 Helicase PhoH PF02562.11 CDF91746.1 - 0.0074 15.5 0.0 0.019 14.2 0.0 1.6 1 0 0 1 1 1 1 PhoH-like protein AAA_16 PF13191.1 CDF91746.1 - 0.031 14.2 0.1 0.085 12.8 0.1 1.7 1 0 0 1 1 1 0 AAA ATPase domain PIF1 PF05970.9 CDF91746.1 - 0.05 12.5 0.0 4.9 5.9 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase T2SE PF00437.15 CDF91746.1 - 0.06 12.2 0.0 0.1 11.4 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DEAD PF00270.24 CDF91746.1 - 0.073 12.5 0.0 0.15 11.5 0.0 1.5 1 1 0 1 1 1 0 DEAD/DEAH box helicase SUI1 PF01253.17 CDF91750.1 - 5.7e-29 99.7 2.0 7.4e-29 99.3 1.4 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 Cir_N PF10197.4 CDF91751.1 - 0.00071 19.5 4.9 0.00071 19.5 3.4 2.7 2 1 0 2 2 2 1 N-terminal domain of CBF1 interacting co-repressor CIR CWC25 PF12542.3 CDF91751.1 - 0.013 15.9 6.9 0.013 15.9 4.8 2.6 1 1 1 2 2 2 0 Pre-mRNA splicing factor DUF2666 PF10869.3 CDF91751.1 - 0.059 13.3 3.0 0.072 13.1 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2666) DUF4144 PF13642.1 CDF91751.1 - 0.1 12.9 2.5 0.13 12.6 1.8 1.1 1 0 0 1 1 1 0 protein structure with unknown function Hid1 PF12722.2 CDF91751.1 - 0.55 7.8 11.2 0.62 7.6 7.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein UPF0565 PF10561.4 CDF91751.1 - 0.67 8.7 5.3 0.8 8.5 3.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Exonuc_VII_L PF02601.10 CDF91751.1 - 6.8 5.7 10.1 7.8 5.5 7.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit PGAP1 PF07819.8 CDF91752.1 - 6.2e-07 29.2 0.1 2.3e-06 27.3 0.0 1.9 2 0 0 2 2 2 1 PGAP1-like protein Abhydrolase_6 PF12697.2 CDF91752.1 - 2.8e-06 27.3 0.0 9.2e-06 25.6 0.0 1.8 3 0 0 3 3 3 1 Alpha/beta hydrolase family LCAT PF02450.10 CDF91752.1 - 3.1e-06 26.4 0.0 5.6e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_1 PF00561.15 CDF91752.1 - 0.00013 21.5 0.0 0.00039 20.0 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_8 PF06259.7 CDF91752.1 - 0.00082 18.9 0.0 0.0015 18.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase DUF900 PF05990.7 CDF91752.1 - 0.0012 18.1 0.0 0.0022 17.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Ser_hydrolase PF06821.8 CDF91752.1 - 0.0042 16.7 0.0 0.0082 15.7 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase Abhydrolase_5 PF12695.2 CDF91752.1 - 0.016 14.9 0.0 0.033 13.9 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family DnaJ PF00226.26 CDF91753.1 - 5.3e-17 61.3 0.0 7.2e-17 60.8 0.0 1.2 1 0 0 1 1 1 1 DnaJ domain zf-CSL PF05207.8 CDF91753.1 - 6.2e-14 51.2 0.9 1.1e-13 50.4 0.6 1.4 1 0 0 1 1 1 1 CSL zinc finger UBA_2 PF08587.6 CDF91753.1 - 0.038 14.1 0.1 9.5 6.4 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin associated domain (UBA) RNA_pol_I_A49 PF06870.7 CDF91754.1 - 2.8e-131 437.6 0.6 3.2e-131 437.4 0.4 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor FGGY_C PF02782.11 CDF91755.1 - 2e-22 79.7 0.0 3e-22 79.2 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.16 CDF91755.1 - 2.9e-07 30.0 0.0 6.5e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Hexokinase_1 PF00349.16 CDF91755.1 - 0.025 13.8 0.1 0.12 11.6 0.0 2.0 2 0 0 2 2 2 0 Hexokinase Papo_T_antigen PF02380.10 CDF91755.1 - 0.2 11.5 5.3 2.6 8.0 0.0 3.7 4 0 0 4 4 4 0 T-antigen specific domain RRM_1 PF00076.17 CDF91757.1 - 1.2e-05 24.8 0.0 2.1e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_6 PF14259.1 CDF91757.1 - 1.4e-05 24.9 0.0 2.5e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) CTK3 PF12243.3 CDF91757.1 - 0.014 15.0 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 RRM_5 PF13893.1 CDF91757.1 - 0.015 15.1 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spo7_2_N PF15407.1 CDF91757.1 - 0.037 13.4 0.0 0.078 12.4 0.0 1.5 1 0 0 1 1 1 0 Sporulation protein family 7 MRP-L46 PF11788.3 CDF91758.1 - 7.2e-37 126.4 0.1 1.2e-36 125.7 0.0 1.3 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 WD40 PF00400.27 CDF91759.1 - 1e-15 56.9 14.3 1.3e-08 34.3 0.6 5.7 5 0 0 5 5 5 4 WD domain, G-beta repeat Nucleoporin_N PF08801.6 CDF91759.1 - 0.025 13.3 1.0 11 4.6 0.0 3.3 1 1 1 3 3 3 0 Nup133 N terminal like Hira PF07569.6 CDF91759.1 - 0.029 13.5 2.7 3.4 6.8 0.0 4.1 2 1 1 5 5 5 0 TUP1-like enhancer of split DUF1997 PF09366.5 CDF91759.1 - 0.079 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1997) Tub_2 PF04525.7 CDF91759.1 - 0.1 11.9 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 Tubby C 2 RTC4 PF14474.1 CDF91760.1 - 3.5e-35 120.6 0.0 6.6e-35 119.7 0.0 1.4 1 0 0 1 1 1 1 RTC4-like domain zf-CCHC PF00098.18 CDF91761.1 - 6.1e-53 174.3 47.8 1.4e-08 34.2 1.3 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.1 CDF91761.1 - 2.7e-12 46.1 43.6 0.0046 16.5 0.4 7.1 6 1 1 7 7 7 7 Zinc knuckle zf-CCHC_3 PF13917.1 CDF91761.1 - 6.2e-06 25.8 48.1 0.16 11.7 0.7 7.1 2 2 5 7 7 7 6 Zinc knuckle zf-CCHC_6 PF15288.1 CDF91761.1 - 0.044 13.4 2.0 0.044 13.4 1.4 6.8 7 0 0 7 7 7 0 Zinc knuckle zf-CCHC_2 PF13696.1 CDF91761.1 - 0.1 12.1 43.8 0.13 11.8 0.5 7.0 3 3 4 7 7 7 0 Zinc knuckle FAD_binding_3 PF01494.14 CDF91762.1 - 9.5e-20 70.9 0.2 5.6e-12 45.3 0.0 3.1 2 1 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.7 CDF91762.1 - 0.00024 20.1 0.1 0.005 15.7 0.1 2.6 3 0 0 3 3 3 1 Lycopene cyclase protein DAO PF01266.19 CDF91762.1 - 0.0014 17.6 0.0 0.027 13.3 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase SE PF08491.5 CDF91762.1 - 0.0021 16.9 0.0 0.0033 16.3 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase Pyr_redox_2 PF07992.9 CDF91762.1 - 0.0066 16.3 0.0 0.015 15.1 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 CDF91762.1 - 0.0095 15.7 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.1 CDF91762.1 - 0.011 15.7 0.0 0.026 14.5 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CDF91762.1 - 0.027 14.5 0.0 0.063 13.3 0.0 1.8 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 CDF91762.1 - 0.049 12.4 0.1 0.072 11.9 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.9 CDF91762.1 - 0.11 10.9 0.1 0.16 10.3 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Trp_halogenase PF04820.9 CDF91762.1 - 0.12 11.0 0.0 0.71 8.4 0.0 2.1 3 0 0 3 3 3 0 Tryptophan halogenase Thi4 PF01946.12 CDF91762.1 - 0.12 11.4 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Thi4 family RRM_1 PF00076.17 CDF91763.1 - 3.3e-15 55.4 0.0 6.6e-15 54.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pro_isomerase PF00160.16 CDF91763.1 - 2.4e-14 53.8 0.0 4.2e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_6 PF14259.1 CDF91763.1 - 6e-13 48.5 0.0 1.3e-12 47.4 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.1 CDF91763.1 - 2.2e-11 43.4 0.2 6.6e-11 41.8 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF676 PF05057.9 CDF91764.1 - 1.6e-05 24.3 0.0 4.2e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 Putative serine esterase (DUF676) PGAP1 PF07819.8 CDF91764.1 - 9.5e-05 22.0 0.1 0.00021 20.9 0.0 1.7 1 1 0 1 1 1 1 PGAP1-like protein DUF915 PF06028.6 CDF91764.1 - 0.002 17.2 0.1 0.031 13.3 0.0 2.7 3 0 0 3 3 3 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_6 PF12697.2 CDF91764.1 - 0.01 15.7 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CDF91764.1 - 0.011 15.5 0.0 0.059 13.1 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDF91764.1 - 0.041 13.4 0.0 0.066 12.7 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold PH PF00169.24 CDF91765.1 - 4.3e-07 30.0 3.5 2.7e-06 27.5 0.3 3.3 4 0 0 4 4 4 1 PH domain Proteasome_A_N PF10584.4 CDF91765.1 - 0.028 13.7 0.1 0.26 10.6 0.0 2.5 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature Dsl1_N PF11988.3 CDF91766.1 - 1.5e-112 376.0 4.4 2.5e-112 375.3 3.0 1.3 1 0 0 1 1 1 1 Retrograde transport protein Dsl1 N terminal Dsl1_C PF11989.3 CDF91766.1 - 5.7e-94 314.5 6.3 1.8e-93 312.9 4.4 1.8 1 1 0 1 1 1 1 Retrograde transport protein Dsl1 C terminal HMA PF00403.21 CDF91767.1 - 4e-10 39.6 0.1 5.1e-10 39.3 0.1 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain Tox-PL-2 PF15643.1 CDF91767.1 - 0.046 13.7 0.1 0.33 10.9 0.0 1.9 1 1 0 1 1 1 0 Papain fold toxin 2 Yae1_N PF09811.4 CDF91768.1 - 3e-07 29.8 6.0 1e-06 28.1 4.1 1.8 1 1 0 1 1 1 1 Essential protein Yae1, N terminal GYF PF02213.11 CDF91769.1 - 1.4e-11 43.7 3.2 3.3e-11 42.6 2.2 1.7 1 0 0 1 1 1 1 GYF domain ORC5_C PF14630.1 CDF91770.1 - 7.6e-62 209.2 0.1 1.2e-61 208.5 0.1 1.4 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.1 CDF91770.1 - 2.8e-05 24.1 0.0 9e-05 22.5 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 CDF91770.1 - 0.00022 21.3 0.0 0.00048 20.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 CDF91770.1 - 0.0094 15.6 0.6 0.35 10.5 0.4 2.3 1 1 0 1 1 1 1 NACHT domain ResIII PF04851.10 CDF91770.1 - 0.032 14.0 0.0 0.06 13.1 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit FtsK_SpoIIIE PF01580.13 CDF91770.1 - 0.04 13.3 0.0 0.084 12.3 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family DAP3 PF10236.4 CDF91770.1 - 0.053 12.4 0.0 0.85 8.4 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_14 PF13173.1 CDF91770.1 - 0.065 13.1 0.0 0.15 11.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain DUF1744 PF08490.7 CDF91771.1 - 5.3e-138 459.9 3.1 8.4e-138 459.2 2.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.14 CDF91771.1 - 2.3e-68 230.4 4.2 2.2e-67 227.2 1.2 2.5 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.16 CDF91771.1 - 7.6e-24 84.3 0.8 2.1e-23 82.8 0.6 1.7 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.4 CDF91771.1 - 1.5e-07 31.1 0.3 1.2e-06 28.2 0.2 2.4 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB YIF1 PF03878.10 CDF91772.1 - 5.4e-70 235.2 7.1 6.9e-70 234.9 4.9 1.1 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.12 CDF91772.1 - 0.031 13.7 9.9 0.09 12.2 6.9 1.8 1 1 0 1 1 1 0 Yip1 domain DUF202 PF02656.10 CDF91772.1 - 1.6 9.0 6.4 4.1 7.7 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF202) DUF2422 PF10337.4 CDF91773.1 - 8.4e-55 186.3 3.4 8.4e-55 186.3 2.4 3.7 4 1 0 5 5 5 1 Protein of unknown function (DUF2422) FUSC_2 PF13515.1 CDF91773.1 - 2.7e-13 49.9 15.2 2.7e-13 49.9 10.5 2.7 2 2 0 2 2 2 1 Fusaric acid resistance protein-like ALMT PF11744.3 CDF91773.1 - 3.3e-09 35.8 0.6 6.1e-07 28.4 0.0 2.3 2 0 0 2 2 2 2 Aluminium activated malate transporter DUF2421 PF10334.4 CDF91773.1 - 0.00025 20.7 0.8 0.00053 19.6 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2421) FUSC PF04632.7 CDF91773.1 - 7.4 4.8 12.3 0.5 8.7 4.8 1.7 2 0 0 2 2 2 0 Fusaric acid resistance protein family UFD1 PF03152.9 CDF91774.1 - 1.3e-71 239.3 0.0 1.8e-71 238.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 TPR_16 PF13432.1 CDF91775.1 - 1.2e-15 57.7 11.5 0.028 15.1 0.1 7.1 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_11 PF13414.1 CDF91775.1 - 1.8e-14 53.1 21.7 0.00025 20.6 0.1 7.2 6 1 0 7 7 7 3 TPR repeat TPR_12 PF13424.1 CDF91775.1 - 1.5e-10 40.8 19.5 0.00032 20.5 0.1 7.0 5 2 3 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.1 CDF91775.1 - 1.6e-09 37.5 1.6 3.9 8.3 0.0 7.0 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_2 PF07719.12 CDF91775.1 - 1.9e-09 36.7 22.9 0.13 12.2 0.2 10.7 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_19 PF14559.1 CDF91775.1 - 3.3e-08 33.7 8.0 0.037 14.3 0.0 5.8 5 1 2 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.23 CDF91775.1 - 8.7e-07 28.3 20.6 0.021 14.4 0.4 8.6 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_9 PF13371.1 CDF91775.1 - 3e-05 23.7 0.1 0.48 10.3 0.0 4.6 5 1 1 6 6 6 2 Tetratricopeptide repeat Apc3 PF12895.2 CDF91775.1 - 5.9e-05 23.1 22.7 0.47 10.6 2.9 6.0 5 1 1 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.1 CDF91775.1 - 0.00045 20.4 15.5 0.39 11.2 0.0 7.1 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_20 PF14561.1 CDF91775.1 - 0.00049 20.1 4.7 0.33 11.0 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.1 CDF91775.1 - 0.0014 17.7 3.2 1.6 7.7 0.0 4.5 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.1 CDF91775.1 - 0.0033 17.4 24.3 0.027 14.6 0.1 8.0 12 0 0 12 12 8 1 Tetratricopeptide repeat TPR_8 PF13181.1 CDF91775.1 - 0.026 14.2 0.2 0.026 14.2 0.1 7.3 9 0 0 9 9 8 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.1 CDF91775.1 - 0.028 14.6 0.9 3.3 7.9 0.0 2.6 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation TPR_7 PF13176.1 CDF91775.1 - 0.035 13.8 12.9 1 9.3 0.1 6.3 6 0 0 6 6 6 0 Tetratricopeptide repeat Mmp37 PF09139.6 CDF91776.1 - 9.3e-102 340.4 6.3 2.2e-93 312.8 0.7 2.1 1 1 1 2 2 2 2 Mitochondrial matrix Mmp37 PI3_PI4_kinase PF00454.22 CDF91777.1 - 4.6e-29 101.5 0.0 9.3e-29 100.5 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.3 CDF91777.1 - 3.2e-20 71.6 0.0 7.8e-20 70.3 0.0 1.7 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 PI3Ka PF00613.15 CDF91777.1 - 9.7e-08 31.3 2.1 2.3e-07 30.1 1.4 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.1 CDF91777.1 - 0.021 13.8 0.0 0.053 12.5 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) KGK PF08872.5 CDF91777.1 - 0.031 14.4 0.1 0.12 12.4 0.1 2.1 1 0 0 1 1 1 0 KGK domain MGDG_synth PF06925.6 CDF91777.1 - 0.1 12.4 0.5 0.4 10.5 0.2 2.0 2 0 0 2 2 2 0 Monogalactosyldiacylglycerol (MGDG) synthase AA_permease PF00324.16 CDF91778.1 - 1.5e-136 455.5 49.1 1.8e-136 455.2 34.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CDF91778.1 - 2.2e-33 115.4 59.6 8.7e-33 113.4 41.0 1.8 1 1 0 1 1 1 1 Amino acid permease RhodobacterPufX PF11511.3 CDF91778.1 - 0.00011 21.5 1.9 0.011 15.1 0.7 3.2 2 0 0 2 2 2 1 Intrinsic membrane protein PufX FH2 PF02181.18 CDF91780.1 - 1.8e-82 277.2 5.9 1.8e-82 277.2 4.1 3.8 4 1 1 5 5 5 1 Formin Homology 2 Domain Drf_FH3 PF06367.11 CDF91780.1 - 8.9e-39 132.9 0.8 8.9e-39 132.9 0.6 5.8 5 1 1 6 6 6 2 Diaphanous FH3 Domain Drf_GBD PF06371.8 CDF91780.1 - 9.9e-29 100.0 3.2 9.9e-29 100.0 2.2 6.2 5 1 0 5 5 5 1 Diaphanous GTPase-binding Domain Sec2p PF06428.6 CDF91781.1 - 1.3e-26 92.3 13.6 1.3e-26 92.3 9.4 3.2 1 1 0 2 2 2 1 GDP/GTP exchange factor Sec2p DUF2959 PF11172.3 CDF91781.1 - 0.0045 16.7 12.7 0.012 15.4 8.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2959) IncA PF04156.9 CDF91781.1 - 9.3 5.7 28.0 1.2e+02 2.1 19.2 2.8 1 1 0 1 1 1 0 IncA protein Aa_trans PF01490.13 CDF91782.1 - 1.8e-81 273.7 31.2 2e-81 273.5 21.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein TIMELESS PF04821.9 CDF91783.1 - 6.1e-55 186.3 6.4 1.3e-54 185.2 4.4 1.6 1 0 0 1 1 1 1 Timeless protein Peptidase_S8 PF00082.17 CDF91784.1 - 1.4e-25 90.0 2.8 1.8e-25 89.6 2.0 1.1 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.11 CDF91784.1 - 0.00023 21.6 0.0 0.00081 19.9 0.0 1.9 2 0 0 2 2 2 1 Peptidase inhibitor I9 Cyclin_N PF00134.18 CDF91785.1 - 3.9e-34 116.9 2.1 6.7e-34 116.1 0.7 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain Sad1_UNC PF07738.8 CDF91786.1 - 6.6e-35 119.8 0.0 1.6e-34 118.6 0.0 1.7 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Oxidored_FMN PF00724.15 CDF91788.1 - 1.9e-64 217.8 0.0 2.3e-64 217.5 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family 2-Hacid_dh_C PF02826.14 CDF91789.1 - 9.5e-55 184.4 0.0 8.5e-54 181.3 0.0 2.2 2 1 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 CDF91789.1 - 3.7e-15 55.5 0.0 4.9e-15 55.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 CDF91789.1 - 2e-08 34.2 0.2 1.4e-07 31.4 0.0 2.4 3 1 1 4 4 4 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.7 CDF91789.1 - 1.2e-06 28.0 0.1 2e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain F420_oxidored PF03807.12 CDF91789.1 - 0.001 19.4 0.0 0.0027 18.1 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.15 CDF91789.1 - 0.0035 17.4 0.3 0.032 14.3 0.1 2.6 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase AdoHcyase_NAD PF00670.16 CDF91789.1 - 0.01 15.7 0.2 0.094 12.5 0.0 2.4 3 0 0 3 3 3 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ThiF PF00899.16 CDF91789.1 - 0.023 14.5 0.3 0.12 12.2 0.0 2.3 2 0 0 2 2 2 0 ThiF family GSH_synthase PF03199.10 CDF91789.1 - 0.037 14.1 0.1 0.22 11.6 0.0 2.0 2 0 0 2 2 2 0 Eukaryotic glutathione synthase TrkA_N PF02254.13 CDF91789.1 - 0.048 13.6 0.1 0.18 11.8 0.0 2.1 2 0 0 2 2 2 0 TrkA-N domain DUF2770 PF10968.3 CDF91790.1 - 0.17 11.6 2.3 0.36 10.5 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2770) HCO3_cotransp PF00955.16 CDF91791.1 - 6e-58 196.7 13.9 7.9e-35 120.4 1.8 2.1 1 1 1 2 2 2 2 HCO3- transporter family DUF2668 PF10873.3 CDF91791.1 - 0.32 11.1 4.9 7.7 6.6 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2668) BacA PF02673.13 CDF91791.1 - 0.32 10.1 16.5 2 7.5 0.1 4.5 3 2 2 5 5 5 0 Bacitracin resistance protein BacA Spindle_Spc25 PF08234.7 CDF91792.1 - 1.7e-16 59.9 0.3 1.7e-16 59.9 0.2 1.7 2 0 0 2 2 2 1 Chromosome segregation protein Spc25 Atg14 PF10186.4 CDF91792.1 - 0.0023 16.9 15.8 0.0023 16.9 11.0 1.5 2 0 0 2 2 2 1 UV radiation resistance protein and autophagy-related subunit 14 Exo_endo_phos PF03372.18 CDF91793.1 - 8.9e-18 65.1 0.0 1.2e-17 64.6 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Glyco_transf_28 PF03033.15 CDF91794.1 - 1.7e-29 102.3 0.0 3.2e-29 101.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain GRAM PF02893.15 CDF91794.1 - 4.5e-19 67.7 1.9 8.2e-13 47.6 0.0 3.0 4 0 0 4 4 4 2 GRAM domain PH PF00169.24 CDF91794.1 - 8.8e-11 41.9 0.3 4.3e-10 39.7 0.2 2.2 1 0 0 1 1 1 1 PH domain UDPGT PF00201.13 CDF91794.1 - 3.8e-08 32.3 0.0 1.7e-07 30.1 0.0 2.1 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH_11 PF15413.1 CDF91794.1 - 8.9e-05 22.7 2.8 0.00053 20.2 0.1 3.0 2 0 0 2 2 2 1 Pleckstrin homology domain Glyco_tran_28_C PF04101.11 CDF91794.1 - 0.0013 18.4 0.0 0.0036 16.9 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain PH_3 PF14593.1 CDF91794.1 - 0.085 12.7 0.2 0.68 9.8 0.0 2.4 2 0 0 2 2 2 0 PH domain Abhydrolase_1 PF00561.15 CDF91795.1 - 5.1e-58 196.3 0.0 6.7e-58 195.9 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 CDF91795.1 - 2.2e-12 47.3 0.1 1.6e-11 44.5 0.1 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 CDF91795.1 - 1.4e-05 24.8 0.1 0.0015 18.2 0.1 2.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family ABC_membrane PF00664.18 CDF91796.1 - 1e-58 198.9 2.8 1.3e-58 198.5 1.9 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 CDF91796.1 - 9.8e-30 103.6 0.0 3.2e-29 101.9 0.0 2.0 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 CDF91796.1 - 3.9e-07 29.5 1.0 5.5e-06 25.7 0.2 2.5 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_17 PF13207.1 CDF91796.1 - 2.6e-06 28.2 0.0 5.3e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 CDF91796.1 - 4.3e-06 26.8 0.2 1.1e-05 25.4 0.2 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.1 CDF91796.1 - 0.00037 20.5 0.3 0.17 11.8 0.0 2.6 2 1 1 3 3 3 1 AAA domain AAA_25 PF13481.1 CDF91796.1 - 0.00048 19.5 0.0 0.004 16.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 CDF91796.1 - 0.00082 19.5 0.0 0.0029 17.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 CDF91796.1 - 0.0012 18.3 0.0 0.0028 17.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_18 PF13238.1 CDF91796.1 - 0.0014 18.9 0.0 0.0085 16.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 CDF91796.1 - 0.0031 17.0 0.0 0.13 11.6 0.0 2.4 2 0 0 2 2 2 1 AAA-like domain T2SE PF00437.15 CDF91796.1 - 0.0041 16.0 0.0 0.0071 15.2 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein DEAD PF00270.24 CDF91796.1 - 0.0041 16.6 0.0 0.017 14.5 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase Zeta_toxin PF06414.7 CDF91796.1 - 0.006 15.6 0.0 0.012 14.7 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin SbcCD_C PF13558.1 CDF91796.1 - 0.019 14.8 0.4 0.079 12.8 0.3 2.0 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_19 PF13245.1 CDF91796.1 - 0.02 14.6 0.0 0.089 12.5 0.0 2.1 1 0 0 1 1 1 0 Part of AAA domain AAA PF00004.24 CDF91796.1 - 0.02 15.0 0.0 0.27 11.4 0.0 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) FtsK_SpoIIIE PF01580.13 CDF91796.1 - 0.026 13.9 0.0 0.054 12.9 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF87 PF01935.12 CDF91796.1 - 0.028 14.2 0.0 0.06 13.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF87 DUF258 PF03193.11 CDF91796.1 - 0.031 13.4 0.0 0.082 12.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_5 PF07728.9 CDF91796.1 - 0.038 13.7 0.0 0.13 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 CDF91796.1 - 0.05 13.0 0.0 2.2 7.6 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_14 PF13173.1 CDF91796.1 - 0.077 12.9 0.0 0.52 10.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.20 CDF91796.1 - 0.09 12.2 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain PH PF00169.24 CDF91797.1 - 1.2e-07 31.8 0.7 3.4e-05 23.9 0.0 3.3 3 0 0 3 3 3 1 PH domain DUF3458 PF11940.3 CDF91797.1 - 0.025 13.4 0.0 0.041 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3458) YbaJ PF10757.4 CDF91798.1 - 0.038 14.1 1.6 0.23 11.6 0.1 2.6 2 0 0 2 2 2 0 Biofilm formation regulator YbaJ EMG1 PF03587.9 CDF91799.1 - 1.3e-75 253.1 0.0 1.5e-75 252.9 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase LCD1 PF09798.4 CDF91800.1 - 6.9e-178 592.6 16.5 8e-178 592.4 11.4 1.0 1 0 0 1 1 1 1 DNA damage checkpoint protein Ribosomal_L37e PF01907.14 CDF91801.1 - 4.9e-28 96.6 12.6 8.1e-28 95.9 8.7 1.3 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.2 CDF91801.1 - 0.00055 19.7 2.0 0.00082 19.1 1.4 1.2 1 0 0 1 1 1 1 Double zinc ribbon SelR PF01641.13 CDF91801.1 - 0.023 14.3 0.4 0.028 14.1 0.3 1.3 1 1 0 1 1 1 0 SelR domain zinc_ribbon_6 PF14599.1 CDF91801.1 - 0.084 12.6 2.8 0.13 12.0 1.9 1.3 1 0 0 1 1 1 0 Zinc-ribbon zf-RING_5 PF14634.1 CDF91801.1 - 0.18 11.5 3.2 0.26 11.0 2.2 1.3 1 0 0 1 1 1 0 zinc-RING finger domain zf-ribbon_3 PF13248.1 CDF91801.1 - 0.22 10.8 3.8 0.55 9.5 2.6 1.7 1 1 0 1 1 1 0 zinc-ribbon domain zf-C3HC4_3 PF13920.1 CDF91801.1 - 0.22 11.2 2.7 0.31 10.7 1.9 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) GATA PF00320.22 CDF91801.1 - 0.44 9.9 6.3 0.49 9.7 0.9 2.3 1 1 1 2 2 2 0 GATA zinc finger zf-C3HC4_2 PF13923.1 CDF91801.1 - 0.94 9.5 4.8 1.4 9.0 3.3 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.20 CDF91801.1 - 1 9.0 4.9 1.6 8.4 3.4 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF2256 PF10013.4 CDF91801.1 - 3.1 7.6 6.5 2 8.2 0.6 2.3 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zinc_ribbon_2 PF13240.1 CDF91801.1 - 4.5 6.8 5.8 38 3.9 0.2 2.2 1 1 1 2 2 2 0 zinc-ribbon domain FHA PF00498.21 CDF91802.1 - 1.9e-08 34.2 0.0 6.4e-08 32.6 0.0 1.9 1 0 0 1 1 1 1 FHA domain Ank_5 PF13857.1 CDF91803.1 - 3.7e-15 55.5 0.5 2.6e-06 27.5 0.1 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.2 CDF91803.1 - 8.8e-14 51.6 0.0 4.3e-06 26.9 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.25 CDF91803.1 - 9.1e-14 50.4 0.6 1.3e-05 24.7 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.1 CDF91803.1 - 4.3e-13 48.1 0.4 0.00011 22.0 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.1 CDF91803.1 - 1.4e-09 38.1 0.2 0.0037 17.7 0.0 3.6 3 1 1 4 4 4 3 Ankyrin repeats (many copies) DUF479 PF04336.7 CDF91803.1 - 0.032 14.3 0.5 24 5.1 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function, DUF479 FlxA PF14282.1 CDF91803.1 - 0.11 12.4 2.1 0.33 10.9 1.5 1.9 1 0 0 1 1 1 0 FlxA-like protein DUF1664 PF07889.7 CDF91803.1 - 0.14 11.9 2.4 0.77 9.5 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) IncA PF04156.9 CDF91803.1 - 0.22 11.1 2.6 0.49 9.9 1.8 1.5 1 0 0 1 1 1 0 IncA protein ADIP PF11559.3 CDF91803.1 - 0.72 9.7 8.9 0.61 9.9 3.7 2.3 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DivIVA PF05103.8 CDF91803.1 - 1.1 9.3 7.3 0.77 9.8 3.1 2.1 2 0 0 2 2 2 0 DivIVA protein OmpH PF03938.9 CDF91803.1 - 6.6 6.6 10.5 3.8 7.4 5.4 2.0 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF4200 PF13863.1 CDF91803.1 - 7.5 6.5 13.0 2.4 8.1 5.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) DUF605 PF04652.11 CDF91804.1 - 1.1e-49 169.8 4.5 1.4e-33 116.8 0.6 2.0 1 1 1 2 2 2 2 Vta1 like S-AdoMet_synt_C PF02773.11 CDF91805.1 - 1.9e-74 247.9 0.2 3.1e-74 247.2 0.1 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.11 CDF91805.1 - 3.5e-45 152.8 0.0 6.8e-45 151.8 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.15 CDF91805.1 - 3.7e-44 149.0 0.1 8.1e-44 147.9 0.0 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain PAP2 PF01569.16 CDF91806.1 - 1.6e-19 69.8 1.1 1.6e-19 69.8 0.8 1.8 2 0 0 2 2 2 1 PAP2 superfamily BCLP PF12304.3 CDF91806.1 - 0.002 17.5 0.6 0.0057 16.0 0.1 1.9 2 0 0 2 2 2 1 Beta-casein like protein PDR_assoc PF08370.6 CDF91806.1 - 0.022 14.2 0.2 0.052 13.0 0.2 1.6 1 0 0 1 1 1 0 Plant PDR ABC transporter associated DUF4149 PF13664.1 CDF91806.1 - 0.036 14.1 0.0 0.036 14.1 0.0 3.2 4 1 0 4 4 4 0 Domain of unknown function (DUF4149) FUSC_2 PF13515.1 CDF91806.1 - 0.04 13.8 0.7 0.04 13.8 0.5 2.0 3 0 0 3 3 3 0 Fusaric acid resistance protein-like PAP2_C PF14360.1 CDF91806.1 - 0.17 12.1 0.3 0.17 12.1 0.2 2.2 3 0 0 3 3 3 0 PAP2 superfamily C-terminal PBP PF01161.15 CDF91807.1 - 3.1e-30 104.9 0.1 4.1e-30 104.5 0.1 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein PSP1 PF04468.7 CDF91808.1 - 5.8e-36 122.3 0.0 5.8e-36 122.3 0.0 2.4 2 0 0 2 2 2 1 PSP1 C-terminal conserved region Med15 PF09606.5 CDF91808.1 - 0.095 10.8 58.3 0.0062 14.8 26.7 2.3 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal Zip PF02535.17 CDF91808.1 - 3.1 6.7 13.0 3.1 6.7 2.5 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter Serinc PF03348.10 CDF91808.1 - 4.6 5.8 5.9 8 5.0 4.1 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) Cu-oxidase_2 PF07731.9 CDF91809.1 - 5.4e-27 93.9 8.9 1.7e-25 89.1 1.7 4.0 4 1 0 4 4 4 2 Multicopper oxidase Cu-oxidase_3 PF07732.10 CDF91809.1 - 6.1e-24 84.0 5.8 1.2e-18 66.9 0.1 4.4 5 0 0 5 5 5 3 Multicopper oxidase Cu-oxidase PF00394.17 CDF91809.1 - 5.5e-20 71.8 1.5 3e-16 59.7 0.1 3.8 4 1 0 4 4 4 2 Multicopper oxidase DUF3124 PF11322.3 CDF91809.1 - 0.021 14.7 0.4 0.085 12.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3124) Pkinase PF00069.20 CDF91810.1 - 2.6e-70 236.5 0.0 5.1e-70 235.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF91810.1 - 1.8e-32 112.4 0.0 6e-32 110.7 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF91810.1 - 0.0003 19.8 0.0 0.00052 19.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Rad60-SLD PF11976.3 CDF91811.1 - 3.2e-20 71.5 0.1 4.4e-20 71.1 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.18 CDF91811.1 - 1.9e-12 46.3 0.0 2.4e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family Nitroreductase PF00881.19 CDF91812.1 - 1.1e-07 31.7 0.1 1.8e-07 31.1 0.0 1.3 1 1 0 1 1 1 1 Nitroreductase family SKG6 PF08693.5 CDF91813.1 - 4.5e-05 22.6 0.0 8.9e-05 21.7 0.0 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain SH3_9 PF14604.1 CDF91813.1 - 0.001 18.6 0.0 0.0023 17.4 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 CDF91813.1 - 0.0034 16.7 0.4 0.0099 15.2 0.0 2.0 3 0 0 3 3 3 1 SH3 domain SH3_2 PF07653.12 CDF91813.1 - 0.01 15.2 0.0 0.043 13.3 0.0 2.1 1 1 0 1 1 1 0 Variant SH3 domain Myc_target_1 PF15179.1 CDF91813.1 - 0.049 13.2 1.6 0.056 13.0 0.0 1.8 2 0 0 2 2 2 0 Myc target protein 1 DUF4448 PF14610.1 CDF91813.1 - 0.052 13.0 0.0 0.13 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) CAP PF00188.21 CDF91814.1 - 5.2e-19 68.9 4.7 5.2e-19 68.9 3.3 3.2 2 1 0 2 2 2 1 Cysteine-rich secretory protein family TPR_16 PF13432.1 CDF91815.1 - 0.076 13.7 0.0 0.23 12.1 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat CAP_GLY PF01302.20 CDF91816.1 - 7.1e-17 60.8 0.3 1.4e-16 59.9 0.1 1.6 2 0 0 2 2 1 1 CAP-Gly domain CCDC144C PF14915.1 CDF91816.1 - 0.00091 18.2 13.4 0.0018 17.2 9.3 1.4 1 1 0 1 1 1 1 CCDC144C protein coiled-coil region Allexi_40kDa PF05549.6 CDF91816.1 - 0.00094 18.5 2.3 0.00094 18.5 1.6 2.0 1 1 1 2 2 2 1 Allexivirus 40kDa protein DUF3584 PF12128.3 CDF91816.1 - 0.0018 15.6 11.4 0.0024 15.2 7.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Bacillus_HBL PF05791.6 CDF91816.1 - 0.015 14.7 3.4 0.027 13.8 2.4 1.5 1 1 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) PspA_IM30 PF04012.7 CDF91816.1 - 0.026 13.8 16.4 0.19 11.0 11.5 2.4 1 1 0 1 1 1 0 PspA/IM30 family FH2 PF02181.18 CDF91816.1 - 0.036 12.9 3.8 1.7 7.4 0.5 2.1 1 1 1 2 2 2 0 Formin Homology 2 Domain Effector_1 PF04518.7 CDF91816.1 - 0.042 12.8 5.8 0.32 9.9 1.1 2.1 1 1 1 2 2 2 0 Effector from type III secretion system Hrs_helical PF12210.3 CDF91816.1 - 0.043 14.0 3.1 3.9 7.8 0.5 3.1 2 1 1 3 3 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Lebercilin PF15619.1 CDF91816.1 - 0.048 13.0 18.8 0.022 14.1 9.9 2.0 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease AAA_13 PF13166.1 CDF91816.1 - 0.11 10.8 9.8 0.021 13.3 3.2 1.7 1 1 1 2 2 2 0 AAA domain GAS PF13851.1 CDF91816.1 - 0.16 11.1 14.7 2.5 7.2 6.0 2.2 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF812 PF05667.6 CDF91816.1 - 0.33 9.3 12.5 0.45 8.9 8.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Ead_Ea22 PF13935.1 CDF91816.1 - 0.34 11.2 11.6 2.1 8.6 8.0 2.2 1 1 2 3 3 2 0 Ead/Ea22-like protein DUF4407 PF14362.1 CDF91816.1 - 0.36 9.7 10.3 3.3 6.6 7.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1319 PF07028.6 CDF91816.1 - 0.59 10.3 10.6 0.063 13.4 1.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) ADIP PF11559.3 CDF91816.1 - 0.62 9.9 16.8 4.8 7.0 6.1 2.4 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF883 PF05957.8 CDF91816.1 - 0.79 10.1 9.5 0.066 13.6 1.4 2.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Mnd1 PF03962.10 CDF91816.1 - 0.88 9.2 14.4 16 5.0 7.9 2.6 1 1 1 2 2 2 0 Mnd1 family Occludin_ELL PF07303.8 CDF91816.1 - 0.99 10.1 11.4 2.4 8.9 0.4 3.2 1 1 2 3 3 3 0 Occludin homology domain Nup54 PF13874.1 CDF91816.1 - 0.99 9.0 13.9 0.62 9.7 7.9 1.8 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 OmpH PF03938.9 CDF91816.1 - 1.1 9.2 11.0 1.8 8.4 7.6 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) GrpE PF01025.14 CDF91816.1 - 1.2 8.6 13.3 3.2 7.2 9.2 1.7 1 1 0 1 1 1 0 GrpE ATG16 PF08614.6 CDF91816.1 - 1.6 8.5 17.5 2.2 8.0 6.8 2.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) CorA PF01544.13 CDF91816.1 - 1.6 7.6 10.3 11 4.8 0.5 2.1 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein APG6 PF04111.7 CDF91816.1 - 1.7 7.6 13.8 2.9 6.8 9.5 1.4 1 0 0 1 1 1 0 Autophagy protein Apg6 Spc42p PF11544.3 CDF91816.1 - 1.9 8.4 8.8 13 5.7 5.1 2.5 1 1 1 2 2 2 0 Spindle pole body component Spc42p Atg14 PF10186.4 CDF91816.1 - 2.2 7.1 14.9 1.5 7.7 4.6 2.2 1 1 2 3 3 3 0 UV radiation resistance protein and autophagy-related subunit 14 TPR_MLP1_2 PF07926.7 CDF91816.1 - 4 7.1 15.4 25 4.6 10.5 2.2 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Fib_alpha PF08702.5 CDF91816.1 - 6.7 6.8 9.2 2.4 8.2 0.8 2.4 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family FUSC PF04632.7 CDF91816.1 - 9.2 4.5 9.0 4.3 5.6 4.3 1.4 1 1 0 1 1 1 0 Fusaric acid resistance protein family Histidinol_dh PF00815.15 CDF91817.1 - 7.1e-183 607.9 4.4 9.4e-183 607.5 3.0 1.1 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.13 CDF91817.1 - 1.1e-27 95.4 0.1 2.4e-27 94.3 0.1 1.6 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.12 CDF91817.1 - 5e-12 45.9 0.2 1.4e-11 44.5 0.1 1.8 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase DUF755 PF05501.6 CDF91817.1 - 0.078 13.0 1.7 4.2 7.4 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF755) RRP7 PF12923.2 CDF91818.1 - 1.6e-33 115.4 8.5 1.6e-33 115.4 5.9 1.5 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) Ste50p-SAM PF09235.5 CDF91819.1 - 2.1e-25 88.5 0.6 4.7e-25 87.4 0.4 1.6 1 0 0 1 1 1 1 Ste50p, sterile alpha motif RA PF00788.18 CDF91819.1 - 6.6e-15 55.3 0.1 1.4e-14 54.3 0.1 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_1 PF00536.25 CDF91819.1 - 0.11 12.7 0.1 1.8 8.7 0.1 2.5 2 1 0 2 2 2 0 SAM domain (Sterile alpha motif) Pilus_CpaD PF09476.5 CDF91819.1 - 0.13 11.7 1.5 0.2 11.1 0.1 1.8 2 0 0 2 2 2 0 Pilus biogenesis CpaD protein (pilus_cpaD) DUF1319 PF07028.6 CDF91819.1 - 0.23 11.6 4.4 1.1 9.4 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1319) DUF3128 PF11326.3 CDF91820.1 - 4e-30 103.7 2.4 4.4e-30 103.6 1.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) CHCH PF06747.8 CDF91820.1 - 0.26 11.2 5.1 7.7 6.5 1.1 2.4 2 0 0 2 2 2 0 CHCH domain SelR PF01641.13 CDF91821.1 - 5.8e-51 171.3 0.2 7e-51 171.1 0.1 1.1 1 0 0 1 1 1 1 SelR domain GAT PF03127.9 CDF91822.1 - 0.00012 21.9 0.0 0.00027 20.8 0.0 1.5 1 0 0 1 1 1 1 GAT domain VHS PF00790.14 CDF91822.1 - 0.055 13.0 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 VHS domain Glutaredoxin PF00462.19 CDF91823.1 - 8.4e-14 51.3 0.8 1.2e-13 50.8 0.0 1.7 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin_9 PF14595.1 CDF91823.1 - 0.0007 19.1 0.1 0.0012 18.4 0.0 1.5 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_3 PF13192.1 CDF91823.1 - 0.0026 17.5 0.7 0.0044 16.7 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin domain Thioredoxin_2 PF13098.1 CDF91823.1 - 0.012 15.8 0.0 0.018 15.2 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_7 PF13899.1 CDF91823.1 - 0.044 13.8 0.0 0.075 13.0 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like Redoxin PF08534.5 CDF91823.1 - 0.056 12.9 0.0 0.064 12.8 0.0 1.2 1 0 0 1 1 1 0 Redoxin MafB19-deam PF14437.1 CDF91823.1 - 0.077 12.6 0.1 2.1 7.9 0.0 2.1 1 1 1 2 2 2 0 MafB19-like deaminase RNase_T PF00929.19 CDF91825.1 - 0.054 13.7 0.0 0.32 11.2 0.0 2.3 2 1 0 2 2 2 0 Exonuclease Toxin_54 PF15533.1 CDF91825.1 - 0.18 12.0 0.6 3.3 8.0 0.0 2.9 3 0 0 3 3 3 0 Putative toxin 54 La PF05383.12 CDF91826.1 - 1.6e-17 63.0 0.0 3.7e-17 61.8 0.0 1.7 1 0 0 1 1 1 1 La domain ATG22 PF11700.3 CDF91827.1 - 6.1e-152 506.4 29.1 7e-152 506.2 20.2 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.11 CDF91827.1 - 1.9e-07 30.1 42.2 6.1e-07 28.4 13.0 3.4 2 2 2 4 4 4 3 Major Facilitator Superfamily WD40 PF00400.27 CDF91828.1 - 5.6e-20 70.4 3.0 0.0019 17.9 0.2 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat GRASP55_65 PF04495.9 CDF91829.1 - 2.9e-36 124.5 0.0 9.4e-34 116.3 0.0 2.2 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain Thioredoxin PF00085.15 CDF91830.1 - 5e-55 183.5 0.1 5.6e-28 96.6 0.0 4.2 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.1 CDF91830.1 - 3.6e-32 111.6 4.6 6.7e-25 87.9 1.4 4.0 3 2 1 4 4 4 2 Thioredoxin-like domain Thioredoxin_7 PF13899.1 CDF91830.1 - 4.3e-07 29.8 0.0 0.032 14.2 0.0 3.0 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.1 CDF91830.1 - 5.3e-07 29.8 1.3 0.044 13.9 0.1 3.4 2 2 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.1 CDF91830.1 - 2.4e-06 27.5 1.1 0.077 13.1 0.0 3.7 4 0 0 4 4 4 2 Thioredoxin-like Calsequestrin PF01216.12 CDF91830.1 - 6.7e-05 21.8 2.4 0.00014 20.7 0.4 2.5 3 0 0 3 3 3 1 Calsequestrin AhpC-TSA PF00578.16 CDF91830.1 - 8.1e-05 22.3 0.0 0.03 13.9 0.0 3.1 3 1 1 4 4 4 1 AhpC/TSA family Redoxin PF08534.5 CDF91830.1 - 0.00022 20.7 0.6 0.99 8.9 0.0 2.9 2 1 0 3 3 3 2 Redoxin Thioredoxin_4 PF13462.1 CDF91830.1 - 0.03 14.3 0.1 14 5.6 0.0 3.1 2 0 0 2 2 2 0 Thioredoxin Thioredoxin_9 PF14595.1 CDF91830.1 - 0.037 13.5 0.2 5.6 6.5 0.0 2.9 2 0 0 2 2 2 0 Thioredoxin Mgr1 PF08602.5 CDF91831.1 - 8.7e-137 455.9 0.5 1.5e-136 455.1 0.4 1.4 1 1 0 1 1 1 1 Mgr1-like, i-AAA protease complex subunit DUF1620 PF07774.8 CDF91832.1 - 1.9e-69 233.2 0.0 2.8e-69 232.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1620) PQQ_2 PF13360.1 CDF91832.1 - 0.028 13.8 0.0 0.25 10.7 0.0 2.5 1 1 1 2 2 2 0 PQQ-like domain PQQ PF01011.16 CDF91832.1 - 0.11 12.0 0.1 13 5.5 0.0 2.8 2 0 0 2 2 2 0 PQQ enzyme repeat FKBP_C PF00254.23 CDF91833.1 - 1.1e-32 111.8 0.0 1.4e-32 111.5 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase CTP_transf_2 PF01467.21 CDF91834.1 - 2.5e-08 34.1 1.3 3.1e-07 30.5 0.9 2.2 1 1 0 1 1 1 1 Cytidylyltransferase ATP-sulfurylase PF01747.12 CDF91834.1 - 0.017 14.4 0.1 0.034 13.4 0.0 1.5 2 0 0 2 2 2 0 ATP-sulfurylase Zn_clus PF00172.13 CDF91835.1 - 0.00013 21.8 4.9 0.00025 20.8 3.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Recep_L_domain PF01030.19 CDF91836.1 - 1e-10 41.5 10.0 0.00015 21.6 0.0 4.6 2 1 2 4 4 4 4 Receptor L domain Ecm33 PF12454.3 CDF91836.1 - 0.014 15.2 0.0 0.068 13.0 0.0 2.2 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein Pkinase PF00069.20 CDF91837.1 - 4.6e-64 216.0 0.0 6.2e-64 215.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF91837.1 - 2.6e-45 154.5 0.0 3.7e-45 154.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF91837.1 - 1.5e-08 33.9 0.0 8.3e-07 28.2 0.0 2.1 2 0 0 2 2 2 2 Kinase-like ArfGap PF01412.13 CDF91838.1 - 7.8e-32 109.5 2.3 2.1e-31 108.1 1.6 1.7 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf QCR10 PF09796.4 CDF91839.1 - 0.009 15.6 1.8 0.009 15.6 1.3 1.8 2 0 0 2 2 2 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) SSP160 PF06933.6 CDF91839.1 - 2.1 6.2 23.6 1.9 6.3 16.4 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF1517 PF07466.6 CDF91839.1 - 5.1 5.9 9.9 5.3 5.9 6.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) Asp_Glu_race PF01177.17 CDF91840.1 - 3.3e-21 76.2 0.0 3.9e-21 75.9 0.0 1.0 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase RPAP1_C PF08620.5 CDF91841.1 - 6.6e-30 102.7 0.0 1.2e-29 101.9 0.0 1.4 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.5 CDF91841.1 - 3.6e-17 61.6 3.3 7.9e-17 60.5 2.3 1.6 1 0 0 1 1 1 1 RPAP1-like, N-terminal HEAT PF02985.17 CDF91841.1 - 0.031 14.3 0.1 0.45 10.7 0.0 2.9 2 0 0 2 2 2 0 HEAT repeat Fumble PF03630.9 CDF91842.1 - 1.3e-126 422.0 1.3 5.1e-124 413.5 0.9 2.1 1 1 0 1 1 1 1 Fumble DUF587 PF04532.7 CDF91842.1 - 0.025 13.5 0.0 0.042 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF587) ATP_transf PF09830.4 CDF91843.1 - 1.5e-21 75.9 0.0 3.3e-21 74.8 0.0 1.6 1 0 0 1 1 1 1 ATP adenylyltransferase HIT PF01230.18 CDF91843.1 - 0.035 14.6 0.0 0.11 13.0 0.0 1.8 1 0 0 1 1 1 0 HIT domain UCR_14kD PF02271.11 CDF91844.1 - 3.1e-44 149.0 0.1 3.5e-44 148.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit PIG-X PF08320.7 CDF91845.1 - 1.2e-48 165.1 0.1 1.7e-48 164.7 0.1 1.2 1 0 0 1 1 1 1 PIG-X / PBN1 Spb1_C PF07780.7 CDF91846.1 - 1e-76 257.2 21.9 1e-76 257.2 15.2 3.4 3 0 0 3 3 3 2 Spb1 C-terminal domain FtsJ PF01728.14 CDF91846.1 - 2.9e-52 177.2 0.1 8.4e-52 175.7 0.1 1.9 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.3 CDF91846.1 - 2.3e-51 173.4 16.7 2.3e-51 173.4 11.6 5.1 4 1 1 5 5 5 1 Domain of unknown function (DUF3381) MT-A70 PF05063.9 CDF91847.1 - 1.9e-11 43.8 0.0 3.8e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 MT-A70 PEX11 PF05648.9 CDF91849.1 - 0.00044 19.6 1.3 0.0013 18.0 0.4 1.9 1 1 1 2 2 2 1 Peroxisomal biogenesis factor 11 (PEX11) Peptidase_M3 PF01432.15 CDF91850.1 - 2.3e-140 468.6 0.9 3.3e-140 468.1 0.6 1.2 1 0 0 1 1 1 1 Peptidase family M3 Mob1_phocein PF03637.12 CDF91850.1 - 0.02 14.5 0.0 0.041 13.5 0.0 1.5 1 0 0 1 1 1 0 Mob1/phocein family Peptidase_M91 PF14891.1 CDF91850.1 - 0.094 12.7 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Effector protein DUF543 PF04418.7 CDF91851.1 - 4.1e-30 103.5 0.2 4.6e-30 103.3 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF543) KH_1 PF00013.24 CDF91853.1 - 0.025 14.2 0.0 0.051 13.2 0.0 1.5 1 0 0 1 1 1 0 KH domain KH_3 PF13014.1 CDF91853.1 - 0.049 13.2 0.0 0.098 12.3 0.0 1.5 1 0 0 1 1 1 0 KH domain DUF4337 PF14235.1 CDF91853.1 - 0.094 12.5 0.8 0.15 11.9 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Atrophin-1 PF03154.10 CDF91853.1 - 8.8 4.3 11.8 12 3.8 8.2 1.1 1 0 0 1 1 1 0 Atrophin-1 family MRC1 PF09444.5 CDF91854.1 - 1.5e-43 148.5 13.8 1.5e-43 148.5 9.5 6.2 2 1 4 6 6 6 1 MRC1-like domain Cytadhesin_P30 PF07271.6 CDF91854.1 - 6.1 6.0 8.4 0.22 10.7 0.7 2.2 2 0 0 2 2 2 0 Cytadhesin P30/P32 EcoR124_C PF12008.3 CDF91855.1 - 1 8.4 6.5 2.2 7.4 0.1 3.1 3 0 0 3 3 3 0 Type I restriction and modification enzyme - subunit R C terminal Fcf2 PF08698.6 CDF91857.1 - 7.3e-27 93.2 0.0 1.2e-26 92.6 0.0 1.3 1 0 0 1 1 1 1 Fcf2 pre-rRNA processing tRNA-synt_2d PF01409.15 CDF91859.1 - 2.5e-89 298.7 0.0 3.3e-89 298.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 CDF91859.1 - 1e-06 28.4 0.1 3.1e-06 26.8 0.0 1.7 1 1 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2 PF00152.15 CDF91859.1 - 6.4e-06 25.1 0.2 0.0001 21.2 0.0 2.7 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA-synt_His PF13393.1 CDF91859.1 - 0.07 12.1 0.0 0.21 10.5 0.0 1.8 2 0 0 2 2 2 0 Histidyl-tRNA synthetase GCR1_C PF12550.3 CDF91861.1 - 1.7e-12 47.0 0.3 5.4e-09 35.7 0.1 2.5 2 0 0 2 2 2 2 Transcriptional activator of glycolytic enzymes DUF3835 PF12927.2 CDF91862.1 - 8e-16 58.7 0.1 8e-16 58.7 0.1 7.5 8 1 1 9 9 9 2 Domain of unknown function (DUF3835) Prefoldin PF02996.12 CDF91862.1 - 1.2e-06 28.1 0.2 1.2e-06 28.1 0.1 3.6 4 0 0 4 4 4 1 Prefoldin subunit PGAP1 PF07819.8 CDF91864.1 - 3.1e-89 298.4 0.0 4.4e-89 297.9 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_5 PF12695.2 CDF91864.1 - 0.0023 17.6 0.0 0.0049 16.6 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 CDF91864.1 - 0.004 17.0 0.0 0.0071 16.2 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 CDF91864.1 - 0.014 15.0 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.20 CDF91864.1 - 0.064 12.8 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) DUF4494 PF14902.1 CDF91864.1 - 0.1 12.2 0.1 0.23 11.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4494) LCAT PF02450.10 CDF91864.1 - 0.12 11.3 0.0 0.21 10.5 0.0 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF3496 PF12001.3 CDF91864.1 - 0.13 12.5 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3496) STE2 PF02116.10 CDF91865.1 - 6.6e-90 300.9 22.6 8.1e-90 300.7 15.6 1.1 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR Romo1 PF10247.4 CDF91865.1 - 0.081 13.1 0.3 0.23 11.6 0.2 1.8 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 RabGAP-TBC PF00566.13 CDF91866.1 - 1.8e-17 63.5 7.9 1.4e-16 60.6 5.5 2.3 1 1 0 1 1 1 1 Rab-GTPase-TBC domain DUF4337 PF14235.1 CDF91866.1 - 0.067 13.0 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF3671 PF12420.3 CDF91866.1 - 0.24 11.3 5.7 0.19 11.7 1.1 2.4 2 0 0 2 2 2 0 Protein of unknown function WD40 PF00400.27 CDF91867.1 - 5.3e-13 48.3 1.0 0.0061 16.4 0.0 6.3 7 0 0 7 7 7 5 WD domain, G-beta repeat ABC_tran PF00005.22 CDF91868.1 - 3.4e-16 59.7 0.0 1.3e-15 57.9 0.0 1.9 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 CDF91868.1 - 2.9e-09 37.3 0.9 0.00064 19.7 0.2 2.2 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.1 CDF91868.1 - 3.2e-05 23.1 0.0 0.047 12.7 0.0 2.1 2 0 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.14 CDF91868.1 - 0.00027 20.2 0.1 0.19 10.9 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 CDF91868.1 - 0.00039 19.8 0.0 0.00079 18.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_10 PF12846.2 CDF91868.1 - 0.0016 17.9 0.2 0.0091 15.4 0.1 1.8 1 1 0 2 2 2 1 AAA-like domain AAA_23 PF13476.1 CDF91868.1 - 0.013 15.8 0.1 0.023 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 CDF91868.1 - 0.017 14.7 0.1 0.032 13.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 CDF91868.1 - 0.019 14.4 0.0 0.032 13.7 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF258 PF03193.11 CDF91868.1 - 0.02 14.0 0.0 0.031 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_17 PF13207.1 CDF91868.1 - 0.022 15.5 0.5 0.041 14.7 0.3 1.9 1 1 0 1 1 1 0 AAA domain Dynamin_N PF00350.18 CDF91868.1 - 0.029 14.1 0.3 0.047 13.4 0.2 1.3 1 0 0 1 1 1 0 Dynamin family PduV-EutP PF10662.4 CDF91868.1 - 0.03 13.8 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation MobB PF03205.9 CDF91868.1 - 0.05 13.3 0.4 1.8 8.2 0.2 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.1 CDF91868.1 - 0.05 12.9 0.0 0.09 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.17 CDF91868.1 - 0.093 12.1 0.1 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain cobW PF02492.14 CDF91868.1 - 0.11 11.8 0.2 0.18 11.2 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.1 CDF91868.1 - 0.13 12.1 0.1 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain FA_hydroxylase PF04116.8 CDF91869.1 - 9.6e-12 45.3 14.2 9.6e-12 45.3 9.8 2.2 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily DUF2636 PF11120.3 CDF91869.1 - 0.054 12.9 0.2 0.13 11.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2636) Pkinase PF00069.20 CDF91870.1 - 6.7e-29 100.8 0.1 3.2e-28 98.5 0.1 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF91870.1 - 9.3e-16 57.6 0.0 1.4e-15 57.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 CDF91870.1 - 5.3e-05 23.0 0.1 0.028 14.1 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.1 CDF91870.1 - 0.015 14.2 0.0 0.024 13.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Pox_ser-thr_kin PF05445.6 CDF91870.1 - 0.029 13.1 0.2 0.04 12.7 0.1 1.3 1 1 0 1 1 1 0 Poxvirus serine/threonine protein kinase Glyco_hydro_47 PF01532.15 CDF91872.1 - 6.1e-85 285.5 1.1 8.2e-85 285.1 0.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 SHMT PF00464.14 CDF91873.1 - 2.5e-208 691.3 0.0 2.9e-208 691.0 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.16 CDF91873.1 - 1.2e-07 30.9 0.0 2.4e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.14 CDF91873.1 - 1.4e-07 30.5 0.0 2e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 CDF91873.1 - 0.00045 19.4 0.0 0.0011 18.2 0.0 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase FR47 PF08445.5 CDF91873.1 - 0.14 11.9 0.0 0.5 10.1 0.0 1.9 2 0 0 2 2 2 0 FR47-like protein Aminotran_5 PF00266.14 CDF91874.1 - 3.3e-26 91.8 0.0 4.3e-26 91.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V B12-binding PF02310.14 CDF91874.1 - 0.0002 21.1 0.0 0.0014 18.4 0.0 2.2 2 0 0 2 2 2 1 B12 binding domain Aminotran_1_2 PF00155.16 CDF91874.1 - 0.005 15.8 0.0 0.0058 15.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II RNase_T PF00929.19 CDF91875.1 - 1.9e-34 119.3 0.7 2.6e-34 118.8 0.5 1.2 1 0 0 1 1 1 1 Exonuclease Pkinase PF00069.20 CDF91876.1 - 1.1e-59 201.7 0.0 5.7e-38 130.5 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.12 CDF91876.1 - 3.9e-25 88.4 0.1 1.1e-19 70.5 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.1 CDF91876.1 - 6.6e-05 22.0 0.1 0.0005 19.1 0.0 2.3 2 1 1 3 3 3 1 Kinase-like Kdo PF06293.9 CDF91876.1 - 8.9e-05 21.6 0.0 0.00016 20.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Response_reg PF00072.19 CDF91876.1 - 0.00062 19.7 0.0 0.0015 18.5 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain APH PF01636.18 CDF91876.1 - 0.0047 16.6 0.0 0.22 11.2 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.6 CDF91876.1 - 0.012 14.4 0.0 0.027 13.2 0.0 1.5 1 0 0 1 1 1 0 Seadornavirus VP7 B3_4 PF03483.12 CDF91877.1 - 6.6e-27 94.0 0.0 1.2e-26 93.2 0.0 1.5 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.10 CDF91877.1 - 1.1e-20 73.2 0.0 4.6e-16 58.4 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetase B5 domain DUF726 PF05277.7 CDF91878.1 - 1.3e-133 445.1 1.1 1.9e-133 444.6 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Ribosomal_L22e PF01776.12 CDF91879.1 - 5.1e-42 142.3 0.5 6.2e-42 142.1 0.4 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family DUF3115 PF11312.3 CDF91880.1 - 2e-99 332.4 0.0 2.3e-99 332.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3115) Mob1_phocein PF03637.12 CDF91881.1 - 1.7e-72 242.7 2.1 2.2e-72 242.4 1.5 1.1 1 0 0 1 1 1 1 Mob1/phocein family RNA_pol PF00940.14 CDF91882.1 - 9.3e-164 544.7 0.1 2.4e-163 543.3 0.0 1.7 2 0 0 2 2 2 1 DNA-dependent RNA polymerase RPOL_N PF14700.1 CDF91882.1 - 2.6e-89 299.6 0.6 4.9e-89 298.7 0.4 1.5 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal UPF0121 PF03661.8 CDF91883.1 - 0.00013 21.2 12.2 0.00019 20.6 8.5 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) Spo7 PF03907.8 CDF91883.1 - 0.31 10.6 4.8 0.59 9.7 3.3 1.5 1 0 0 1 1 1 0 Spo7-like protein O-antigen_lig PF13425.1 CDF91883.1 - 4.2 7.3 9.0 0.29 11.0 1.0 2.3 1 1 1 2 2 2 0 O-antigen ligase like membrane protein Ras PF00071.17 CDF91885.1 - 1.1e-64 216.6 0.5 1.3e-64 216.4 0.3 1.0 1 0 0 1 1 1 1 Ras family Miro PF08477.8 CDF91885.1 - 2.4e-19 69.9 0.1 3.6e-19 69.4 0.1 1.3 1 0 0 1 1 1 1 Miro-like protein Arf PF00025.16 CDF91885.1 - 5.9e-17 61.4 0.2 7.4e-17 61.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.7 CDF91885.1 - 1.7e-06 27.3 0.3 2.2e-06 26.9 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.22 CDF91885.1 - 7.9e-06 25.4 0.2 1.5e-05 24.4 0.1 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.18 CDF91885.1 - 7.6e-05 22.6 0.1 0.0001 22.2 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.5 CDF91885.1 - 0.0018 17.5 0.1 0.0025 17.0 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.1 CDF91885.1 - 0.013 15.6 0.0 0.025 14.7 0.0 1.6 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.11 CDF91885.1 - 0.019 14.1 0.0 0.038 13.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF258 PduV-EutP PF10662.4 CDF91885.1 - 0.022 14.2 0.1 0.084 12.3 0.1 2.1 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.13 CDF91885.1 - 0.032 13.5 0.3 0.2 10.9 0.2 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_5 PF07728.9 CDF91885.1 - 0.044 13.5 0.0 0.069 12.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) YTH PF04146.10 CDF91885.1 - 0.044 13.3 0.1 0.059 12.9 0.1 1.2 1 0 0 1 1 1 0 YT521-B-like domain AAA_16 PF13191.1 CDF91885.1 - 0.045 13.7 0.2 0.21 11.5 0.0 1.9 2 1 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.1 CDF91885.1 - 0.052 13.0 0.0 0.13 11.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.22 CDF91885.1 - 0.13 12.5 0.4 0.3 11.3 0.2 1.9 1 1 0 1 1 1 0 ABC transporter G-alpha PF00503.15 CDF91885.1 - 2.4 6.7 4.6 11 4.5 0.2 2.6 1 1 1 2 2 2 0 G-protein alpha subunit DUF788 PF05620.6 CDF91886.1 - 2.7e-49 167.2 0.0 3.1e-49 167.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF788) Actin PF00022.14 CDF91887.1 - 1.3e-159 530.8 0.0 1.5e-159 530.6 0.0 1.0 1 0 0 1 1 1 1 Actin ESSS PF10183.4 CDF91887.1 - 0.043 14.2 0.0 0.18 12.1 0.0 2.0 1 1 1 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Sugar_tr PF00083.19 CDF91888.1 - 2.9e-48 164.5 17.3 3.3e-48 164.4 12.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.11 CDF91888.1 - 2.9e-19 68.9 31.1 3e-16 59.0 12.4 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 CDF91888.1 - 0.045 12.1 29.4 0.036 12.4 2.1 4.0 3 1 1 4 4 4 0 MFS/sugar transport protein SPC22 PF04573.7 CDF91889.1 - 2.5e-52 176.6 0.5 2.9e-52 176.4 0.4 1.0 1 0 0 1 1 1 1 Signal peptidase subunit PPR_3 PF13812.1 CDF91890.1 - 7.1e-14 50.8 5.9 0.038 14.2 0.0 10.7 12 1 0 12 12 12 3 Pentatricopeptide repeat domain PPR_2 PF13041.1 CDF91890.1 - 1.1e-09 38.1 20.6 7.1e-05 22.6 0.2 8.8 8 2 3 11 11 11 5 PPR repeat family PPR PF01535.15 CDF91890.1 - 6.3e-09 35.2 15.4 0.00018 21.2 0.1 9.1 12 0 0 12 12 12 3 PPR repeat TPR_14 PF13428.1 CDF91890.1 - 0.0071 16.8 0.7 48 4.9 0.0 5.8 7 0 0 7 7 7 0 Tetratricopeptide repeat PPR_1 PF12854.2 CDF91890.1 - 0.0099 15.3 0.0 0.12 11.8 0.0 2.8 2 0 0 2 2 2 1 PPR repeat Arabinose_bd PF12625.2 CDF91890.1 - 0.034 13.9 0.1 0.085 12.6 0.0 1.6 1 0 0 1 1 1 0 Arabinose-binding domain of AraC transcription regulator, N-term SH3_1 PF00018.23 CDF91891.1 - 5.5e-08 32.0 3.3 1.1e-07 31.0 0.1 2.8 3 0 0 3 3 3 1 SH3 domain SH3_9 PF14604.1 CDF91891.1 - 4.5e-06 26.1 0.2 1.5e-05 24.4 0.1 2.0 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.12 CDF91891.1 - 6.2e-05 22.3 0.1 0.00023 20.5 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain rRNA_processing PF08524.6 CDF91892.1 - 4.5e-42 143.3 32.8 4.8e-42 143.2 22.7 1.0 1 0 0 1 1 1 1 rRNA processing PA26 PF04636.8 CDF91892.1 - 1.8 7.1 8.1 1.9 7.0 5.6 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Nop53 PF07767.6 CDF91892.1 - 3.7 6.4 29.0 5 6.0 20.1 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Atrophin-1 PF03154.10 CDF91892.1 - 3.8 5.5 16.0 5.1 5.1 11.1 1.1 1 0 0 1 1 1 0 Atrophin-1 family CAF-1_p150 PF11600.3 CDF91892.1 - 4.6 6.5 35.5 5.8 6.2 24.6 1.1 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal GTP_EFTU PF00009.22 CDF91893.1 - 3.2e-60 202.7 0.3 7.7e-60 201.5 0.2 1.7 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 CDF91893.1 - 1.1e-35 121.8 0.0 2.5e-35 120.6 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.1 CDF91893.1 - 7.5e-30 102.5 0.0 1.6e-29 101.5 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.19 CDF91893.1 - 8.3e-24 83.2 0.0 1.7e-23 82.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 CDF91893.1 - 1.4e-12 47.5 0.2 3.6e-12 46.2 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Miro PF08477.8 CDF91893.1 - 0.0094 16.4 0.0 0.024 15.1 0.0 1.8 1 0 0 1 1 1 1 Miro-like protein Cu-oxidase_2 PF07731.9 CDF91894.1 - 2.5e-42 143.6 9.2 1.6e-39 134.5 1.6 2.7 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.10 CDF91894.1 - 4.3e-37 126.4 7.9 6.9e-35 119.3 1.5 3.2 4 0 0 4 4 4 2 Multicopper oxidase Cu-oxidase PF00394.17 CDF91894.1 - 4.6e-33 114.3 2.6 2.3e-28 99.0 0.0 3.5 3 1 0 3 3 3 2 Multicopper oxidase Med14 PF08638.6 CDF91895.1 - 1.4e-60 203.9 0.8 1.4e-60 203.9 0.5 2.9 3 0 0 3 3 3 1 Mediator complex subunit MED14 GRAM PF02893.15 CDF91896.1 - 1.4e-19 69.3 0.0 2.6e-19 68.4 0.0 1.5 1 0 0 1 1 1 1 GRAM domain DUF1183 PF06682.7 CDF91896.1 - 0.83 9.2 13.0 1.1 8.7 5.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1183) OTU PF02338.14 CDF91897.1 - 2e-11 44.5 0.1 3.9e-11 43.5 0.0 1.6 1 1 0 1 1 1 1 OTU-like cysteine protease DUF4520 PF15016.1 CDF91897.1 - 0.017 14.7 0.0 0.031 13.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4520) zf-C2H2_jaz PF12171.3 CDF91898.1 - 4.3e-09 36.2 5.9 8.5e-09 35.3 4.1 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.2 CDF91898.1 - 5.9e-05 23.1 0.3 9.9e-05 22.3 0.2 1.4 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-AD PF07776.10 CDF91898.1 - 0.019 14.9 0.2 0.054 13.4 0.0 1.8 2 0 0 2 2 2 0 Zinc-finger associated domain (zf-AD) zf-U1 PF06220.7 CDF91898.1 - 0.16 11.5 1.7 0.27 10.8 1.2 1.3 1 0 0 1 1 1 0 U1 zinc finger zf-met PF12874.2 CDF91898.1 - 0.55 10.5 7.3 0.24 11.6 3.1 1.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Ribosomal_L16 PF00252.13 CDF91899.1 - 7.6e-33 113.0 0.1 9.6e-33 112.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e DUF1640 PF07798.6 CDF91901.1 - 3.4e-60 203.0 8.7 3.9e-60 202.9 6.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) HALZ PF02183.13 CDF91901.1 - 0.0051 16.5 0.6 0.056 13.1 0.2 2.6 2 0 0 2 2 2 1 Homeobox associated leucine zipper TBPIP PF07106.8 CDF91901.1 - 0.0056 16.2 5.0 0.0095 15.5 3.5 1.4 1 0 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) FlaC_arch PF05377.6 CDF91901.1 - 0.014 15.2 2.4 0.71 9.8 0.1 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF3410 PF11890.3 CDF91901.1 - 0.13 11.9 5.0 0.057 13.0 1.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3410) V_ATPase_I PF01496.14 CDF91901.1 - 0.23 9.3 2.6 0.27 9.0 1.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Syntaxin PF00804.20 CDF91901.1 - 0.26 11.4 12.3 5.6 7.1 5.4 2.2 1 1 1 2 2 2 0 Syntaxin TPR_MLP1_2 PF07926.7 CDF91901.1 - 0.48 10.1 9.1 0.54 9.9 5.2 1.9 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Baculo_PEP_C PF04513.7 CDF91901.1 - 0.64 9.8 3.4 13 5.6 0.5 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Phage_lysis PF03245.8 CDF91901.1 - 4.4 7.3 9.1 1.6 8.6 0.3 2.4 1 1 1 2 2 2 0 Bacteriophage Rz lysis protein RCC1 PF00415.13 CDF91902.1 - 1.5e-26 92.2 6.3 1.4e-06 28.4 0.0 5.0 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.1 CDF91902.1 - 1.4e-12 46.9 8.7 1.2e-07 31.0 0.0 3.9 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat YcxB PF14317.1 CDF91902.1 - 0.14 11.4 0.6 3.2 7.0 0.0 3.3 3 0 0 3 3 3 0 YcxB-like protein Sec20 PF03908.8 CDF91903.1 - 7.6e-07 28.7 1.9 8.5e-07 28.5 0.3 1.8 2 0 0 2 2 2 1 Sec20 V-SNARE_C PF12352.3 CDF91903.1 - 1.1e-06 28.5 3.7 2e-06 27.7 2.6 1.4 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus FCH PF00611.18 CDF91905.1 - 6.9e-17 61.4 0.0 6.9e-17 61.4 0.0 2.8 3 1 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain RhoGAP PF00620.22 CDF91905.1 - 3.1e-12 46.3 4.5 1.3e-11 44.3 0.1 2.7 2 0 0 2 2 2 1 RhoGAP domain DEP PF00610.16 CDF91905.1 - 4.4e-12 45.5 0.1 1.2e-11 44.1 0.1 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Rdx PF10262.4 CDF91906.1 - 9.6e-26 89.6 0.0 1.4e-25 89.1 0.0 1.3 1 0 0 1 1 1 1 Rdx family Lectin_leg-like PF03388.8 CDF91907.1 - 2.4e-40 138.0 0.1 3.8e-40 137.4 0.1 1.3 1 0 0 1 1 1 1 Legume-like lectin family CHD5 PF04420.9 CDF91907.1 - 0.00067 19.3 0.1 0.0012 18.4 0.1 1.4 1 0 0 1 1 1 1 CHD5-like protein CRC_subunit PF08624.5 CDF91908.1 - 1.2e-27 96.4 0.0 2.6e-27 95.4 0.0 1.5 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit ADH_zinc_N PF00107.21 CDF91909.1 - 1.5e-16 60.1 0.2 2.2e-16 59.5 0.1 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Zip PF02535.17 CDF91910.1 - 2.4e-51 174.6 0.3 2.8e-51 174.4 0.2 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Sod_Cu PF00080.15 CDF91912.1 - 3e-23 82.5 0.0 5.3e-23 81.7 0.0 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) RAP1 PF07218.6 CDF91912.1 - 1 7.3 11.2 1.1 7.2 7.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SnoaL_2 PF12680.2 CDF91913.1 - 0.039 14.3 0.0 0.051 13.9 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like domain DUF1445 PF07286.7 CDF91914.1 - 8.2e-55 184.4 0.0 1e-54 184.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1445) TauD PF02668.11 CDF91915.1 - 1.2e-51 175.8 0.1 1.5e-51 175.5 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Amidase PF01425.16 CDF91916.1 - 7.6e-99 331.5 0.0 8.9e-99 331.3 0.0 1.0 1 0 0 1 1 1 1 Amidase SSF PF00474.12 CDF91917.1 - 1.9e-16 59.7 27.7 1.9e-16 59.7 19.2 2.1 2 0 0 2 2 2 1 Sodium:solute symporter family MFS_1 PF07690.11 CDF91918.1 - 8e-40 136.6 51.5 2.5e-39 135.0 34.9 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily Epimerase PF01370.16 CDF91919.1 - 6.4e-23 81.4 0.0 8.1e-23 81.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 CDF91919.1 - 4.5e-17 61.6 0.0 5.9e-17 61.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 CDF91919.1 - 4.5e-17 61.7 0.0 1.5e-16 60.0 0.0 1.7 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.1 CDF91919.1 - 1.8e-16 60.6 0.0 2.7e-16 60.1 0.0 1.2 1 0 0 1 1 1 1 NADH(P)-binding NmrA PF05368.8 CDF91919.1 - 4.7e-11 42.3 0.0 6.9e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family KR PF08659.5 CDF91919.1 - 2.1e-06 27.5 0.0 6.3e-06 25.9 0.0 1.7 1 1 0 1 1 1 1 KR domain adh_short PF00106.20 CDF91919.1 - 0.00015 21.7 0.0 0.00032 20.6 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.10 CDF91919.1 - 0.0033 16.3 0.0 0.0047 15.8 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.12 CDF91919.1 - 0.12 11.2 0.0 0.21 10.4 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain Aminotran_3 PF00202.16 CDF91920.1 - 5.8e-62 209.5 0.0 7.5e-62 209.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III GATase PF00117.23 CDF91922.1 - 2.5e-11 43.3 0.0 3.2e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Acetyltransf_3 PF13302.1 CDF91923.1 - 1.3e-16 61.0 0.0 1.7e-16 60.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 CDF91923.1 - 1.1e-06 28.6 0.0 1.5e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 CDF91923.1 - 0.00022 21.1 0.0 0.00033 20.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 CDF91923.1 - 0.0013 18.6 0.0 0.0024 17.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family MFS_1 PF07690.11 CDF91924.1 - 1.1e-28 99.9 44.7 2.3e-28 98.9 25.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.8 CDF91924.1 - 5.2e-06 24.9 2.4 8.1e-06 24.3 1.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.8 CDF91924.1 - 1e-05 23.9 0.5 1.6e-05 23.2 0.4 1.2 1 0 0 1 1 1 1 Transmembrane secretion effector Zn_clus PF00172.13 CDF91925.1 - 2e-08 33.9 12.1 5.8e-08 32.5 8.4 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Epimerase PF01370.16 CDF91926.1 - 4.6e-14 52.4 0.0 8.3e-14 51.5 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CDF91926.1 - 3.6e-08 33.6 0.1 1.7e-07 31.4 0.1 2.0 1 1 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 CDF91926.1 - 3e-06 26.1 0.0 4.7e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 CDF91926.1 - 3.7e-05 22.7 0.0 0.00056 18.9 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.10 CDF91926.1 - 0.00053 18.9 0.1 0.00097 18.1 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.8 CDF91926.1 - 0.0026 17.0 0.1 0.015 14.5 0.0 2.1 3 0 0 3 3 3 1 NmrA-like family adh_short PF00106.20 CDF91926.1 - 0.014 15.2 0.0 0.032 14.1 0.0 1.6 2 0 0 2 2 2 0 short chain dehydrogenase RmlD_sub_bind PF04321.12 CDF91926.1 - 0.034 13.0 0.0 0.15 10.9 0.0 1.9 2 0 0 2 2 2 0 RmlD substrate binding domain Shikimate_DH PF01488.15 CDF91926.1 - 0.074 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.12 CDF91926.1 - 0.074 13.4 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent RWD PF05773.17 CDF91927.1 - 0.1 12.4 0.7 0.15 11.9 0.4 1.4 1 1 0 1 1 1 0 RWD domain Thiolase_N PF00108.18 CDF91928.1 - 5.2e-84 281.3 0.0 7.2e-84 280.8 0.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.13 CDF91928.1 - 6.8e-48 161.1 0.4 1.3e-47 160.2 0.3 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.21 CDF91928.1 - 1.4e-05 24.6 0.1 8.5e-05 22.1 0.0 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.5 CDF91928.1 - 0.12 12.0 3.8 0.21 11.2 0.0 2.9 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III FH2 PF02181.18 CDF91929.1 - 2.4e-71 240.5 9.7 2.4e-71 240.5 6.7 2.2 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.8 CDF91929.1 - 2.3e-12 46.6 0.2 2.3e-12 46.6 0.1 2.7 3 1 0 3 3 3 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.11 CDF91929.1 - 7.6e-08 31.9 6.7 7.6e-08 31.9 4.7 2.6 2 0 0 2 2 2 1 Diaphanous FH3 Domain HTH_22 PF13309.1 CDF91929.1 - 0.53 10.0 3.6 5 6.9 0.0 3.5 3 0 0 3 3 3 0 HTH domain SKG6 PF08693.5 CDF91930.1 - 0.0012 18.1 0.2 0.0028 16.9 0.1 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Vpu PF00558.14 CDF91930.1 - 0.077 12.5 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Vpu protein DUF2852 PF11014.3 CDF91930.1 - 4.8 7.1 6.1 41 4.1 0.3 3.6 3 3 0 3 3 3 0 Protein of unknown function (DUF2852) Coa1 PF08695.5 CDF91931.1 - 2.1e-38 130.3 0.0 2.6e-38 130.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 DUF1748 PF08520.5 CDF91932.1 - 2.6e-30 103.8 0.1 2.8e-30 103.7 0.1 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) Myb_DNA-bind_6 PF13921.1 CDF91933.1 - 1.1e-30 105.5 4.0 3.9e-11 42.8 0.0 3.9 2 1 1 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-binding PF00249.26 CDF91933.1 - 6e-29 99.8 9.0 1.3e-11 44.3 0.2 4.0 3 1 0 3 3 3 3 Myb-like DNA-binding domain Rap1_C PF11626.3 CDF91933.1 - 0.028 14.3 2.5 1.4 8.8 0.7 3.0 1 1 1 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain MADF_DNA_bdg PF10545.4 CDF91933.1 - 0.053 13.7 8.1 1 9.6 0.1 4.3 4 0 0 4 4 4 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_5 PF13873.1 CDF91933.1 - 0.083 12.8 6.8 0.64 9.9 0.1 4.0 3 1 0 3 3 3 0 Myb/SANT-like DNA-binding domain UCH PF00443.24 CDF91934.1 - 4.7e-58 196.4 3.4 4.4e-57 193.2 1.4 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.1 CDF91934.1 - 2.1e-22 79.9 0.2 6.5e-22 78.3 0.2 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DAO PF01266.19 CDF91935.1 - 3.3e-49 167.6 0.0 4.2e-49 167.3 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 CDF91935.1 - 4.4e-13 48.8 1.8 2.4e-12 46.4 1.3 1.9 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.2 CDF91935.1 - 1.3e-10 40.9 0.1 7.3e-07 28.6 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.12 CDF91935.1 - 1.3e-05 24.4 0.1 0.11 11.6 0.0 2.9 3 0 0 3 3 3 2 Thi4 family Pyr_redox_2 PF07992.9 CDF91935.1 - 2.1e-05 24.5 0.2 0.00037 20.4 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 CDF91935.1 - 0.00092 18.1 0.8 0.019 13.8 0.1 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.9 CDF91935.1 - 0.0014 17.1 0.3 0.0024 16.3 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.1 CDF91935.1 - 0.0016 18.4 0.7 0.0049 16.8 0.4 1.9 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.7 CDF91935.1 - 0.019 13.8 0.2 0.044 12.6 0.2 1.6 1 0 0 1 1 1 0 Lycopene cyclase protein DUF533 PF04391.7 CDF91935.1 - 0.028 13.7 0.0 0.069 12.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF533) Pyr_redox PF00070.22 CDF91935.1 - 0.061 13.7 0.1 0.19 12.1 0.1 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 CDF91935.1 - 0.11 12.5 0.0 0.26 11.3 0.0 1.8 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 CDF91935.1 - 0.17 11.5 0.7 0.63 9.6 0.5 2.0 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Corona_nucleoca PF00937.13 CDF91936.1 - 0.054 12.4 4.4 0.074 11.9 3.1 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Pap_E4 PF02711.9 CDF91936.1 - 2.2 9.1 5.8 2.9 8.7 3.3 1.9 1 1 0 1 1 1 0 E4 protein PTPA PF03095.10 CDF91937.1 - 2.1e-108 362.0 0.0 2.6e-108 361.7 0.0 1.1 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein PEPCK_ATP PF01293.15 CDF91938.1 - 2.3e-219 728.7 0.0 2.7e-219 728.4 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.1 CDF91938.1 - 0.011 15.6 0.0 0.085 12.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.1 CDF91938.1 - 0.063 12.6 0.1 0.15 11.4 0.0 1.5 2 0 0 2 2 2 0 AAA domain KaiC PF06745.8 CDF91938.1 - 0.088 11.9 0.1 0.16 11.1 0.1 1.3 1 0 0 1 1 1 0 KaiC MRFAP1 PF15155.1 CDF91938.1 - 0.088 13.1 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 MORF4 family-associated protein1 AAA_29 PF13555.1 CDF91938.1 - 0.11 12.0 0.1 0.29 10.6 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain PIN_4 PF13638.1 CDF91940.1 - 5.6e-12 45.9 0.3 1.2e-11 44.8 0.2 1.6 1 0 0 1 1 1 1 PIN domain Pcc1 PF09341.5 CDF91941.1 - 2e-21 75.7 0.0 2.3e-21 75.6 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Pcc1 DAGK_cat PF00781.19 CDF91942.1 - 2.9e-10 39.6 0.0 4.8e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain zf-primase PF09329.6 CDF91943.1 - 9e-16 57.2 0.5 1.6e-15 56.4 0.3 1.4 1 0 0 1 1 1 1 Primase zinc finger tRNA_anti-codon PF01336.20 CDF91943.1 - 0.075 12.8 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain TPR_MLP1_2 PF07926.7 CDF91944.1 - 7.2e-26 90.4 48.6 6.6e-25 87.3 19.4 15.7 6 3 7 14 14 14 3 TPR/MLP1/MLP2-like protein G-gamma PF00631.17 CDF91944.1 - 0.031 14.0 0.0 0.031 14.0 0.0 6.5 5 0 0 5 5 5 0 GGL domain ubiquitin PF00240.18 CDF91945.1 - 1.3e-34 117.3 0.9 1.7e-34 117.0 0.6 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.12 CDF91945.1 - 3.7e-31 106.4 11.3 5.9e-31 105.8 7.8 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.3 CDF91945.1 - 4e-20 71.2 0.7 6.5e-20 70.5 0.5 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.1 CDF91945.1 - 7.1e-06 26.1 0.2 2.6e-05 24.4 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Telomere_Sde2 PF13019.1 CDF91945.1 - 0.0001 22.0 0.0 0.00013 21.7 0.0 1.2 1 0 0 1 1 1 1 Telomere stability and silencing Rad60-SLD_2 PF13881.1 CDF91945.1 - 0.0055 16.5 0.1 0.012 15.5 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.4 CDF91945.1 - 0.012 15.7 0.1 0.013 15.7 0.0 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Fer2_3 PF13085.1 CDF91945.1 - 0.12 12.1 1.5 0.54 10.1 1.1 2.0 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain DUF2870 PF11069.3 CDF91945.1 - 0.12 12.3 0.0 0.27 11.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2870) Response_reg PF00072.19 CDF91946.1 - 2.9e-28 98.1 0.3 5.5e-28 97.2 0.2 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.21 CDF91946.1 - 5.4e-27 93.7 1.7 1e-25 89.5 1.2 2.6 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 CDF91946.1 - 7.8e-11 41.8 0.1 1.9e-10 40.5 0.1 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.20 CDF91946.1 - 0.0064 16.6 8.2 0.38 10.9 0.0 3.1 3 0 0 3 3 3 2 HAMP domain PTR2 PF00854.16 CDF91948.1 - 1.6e-60 204.9 14.6 1.6e-60 204.9 10.2 2.1 1 1 1 2 2 2 2 POT family MFS_1 PF07690.11 CDF91948.1 - 1.4e-08 33.8 27.1 1.4e-08 33.8 18.8 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Arc_PepC_II PF06847.6 CDF91948.1 - 0.053 13.9 0.9 0.79 10.1 0.1 2.7 2 0 0 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II Pantoate_ligase PF02569.10 CDF91949.1 - 2.9e-93 311.6 0.0 3.2e-93 311.5 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Ndc80_HEC PF03801.8 CDF91950.1 - 5.2e-53 178.7 0.3 1.5e-52 177.2 0.0 1.9 2 0 0 2 2 2 1 HEC/Ndc80p family Tektin PF03148.9 CDF91950.1 - 0.046 12.2 40.1 0.046 12.2 5.2 3.3 1 1 2 3 3 3 0 Tektin family Reo_sigmaC PF04582.7 CDF91950.1 - 0.14 11.2 9.0 0.39 9.8 0.5 2.7 2 0 0 2 2 2 0 Reovirus sigma C capsid protein Spc7 PF08317.6 CDF91950.1 - 0.19 10.3 44.3 0.21 10.2 9.1 2.8 2 1 0 2 2 2 0 Spc7 kinetochore protein GAS PF13851.1 CDF91950.1 - 0.99 8.5 49.6 0.02 14.0 11.5 2.5 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Atg14 PF10186.4 CDF91950.1 - 4.3 6.1 49.2 2.1 7.2 9.7 3.6 1 1 2 3 3 3 0 UV radiation resistance protein and autophagy-related subunit 14 Helicase_C_3 PF13625.1 CDF91951.1 - 3e-25 88.4 0.1 1e-24 86.7 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 CDF91951.1 - 2.6e-14 53.4 0.2 1e-13 51.5 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 CDF91951.1 - 1e-12 47.4 0.1 2.1e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.26 CDF91951.1 - 2.5e-10 40.0 0.6 1.3e-09 37.7 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.24 CDF91951.1 - 3e-07 30.0 0.5 6.8e-07 28.9 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_34 PF13872.1 CDF91951.1 - 0.03 13.0 0.0 0.062 12.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 Med3 PF11593.3 CDF91951.1 - 0.26 10.5 14.9 0.61 9.2 7.1 2.2 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal SRP40_C PF05022.7 CDF91952.1 - 3.3e-29 101.1 4.3 3.3e-29 101.1 3.0 2.3 2 0 0 2 2 2 1 SRP40, C-terminal domain Whi5 PF08528.6 CDF91953.1 - 1.9e-09 36.8 0.2 4.1e-09 35.7 0.1 1.5 1 0 0 1 1 1 1 Whi5 like LIM PF00412.17 CDF91954.1 - 7.5e-16 57.9 21.0 5.6e-09 35.9 5.5 2.3 2 0 0 2 2 2 2 LIM domain Arginase PF00491.16 CDF91955.1 - 1.6e-85 286.7 0.0 1.9e-85 286.5 0.0 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.2 CDF91955.1 - 0.068 13.3 0.2 0.11 12.7 0.2 1.3 1 0 0 1 1 1 0 UPF0489 domain HMG14_17 PF01101.13 CDF91956.1 - 0.88 10.3 9.2 0.29 11.8 4.0 1.9 2 0 0 2 2 2 0 HMG14 and HMG17 Ribonuclease_T2 PF00445.13 CDF91957.1 - 1.4e-23 83.5 0.0 2.6e-23 82.6 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease T2 family DUF2009 PF09418.5 CDF91958.1 - 1.7e-225 749.1 3.7 2e-225 748.8 2.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) zf-B_box PF00643.19 CDF91958.1 - 2.2e-05 24.2 8.1 4.8e-05 23.1 5.6 1.6 1 0 0 1 1 1 1 B-box zinc finger IBR PF01485.16 CDF91958.1 - 0.14 12.0 4.5 0.35 10.7 3.1 1.7 1 0 0 1 1 1 0 IBR domain Actin PF00022.14 CDF91959.1 - 9.5e-115 383.1 0.0 1.2e-114 382.8 0.0 1.0 1 0 0 1 1 1 1 Actin UPRTase PF14681.1 CDF91960.1 - 8.5e-77 257.0 0.0 1e-76 256.7 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.22 CDF91960.1 - 0.0041 16.8 0.0 0.0056 16.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Flu_C_NS1 PF03506.8 CDF91960.1 - 0.12 12.1 0.2 0.2 11.4 0.2 1.3 1 0 0 1 1 1 0 Influenza C non-structural protein (NS1) LSM PF01423.17 CDF91961.1 - 4.9e-18 64.4 0.1 6.6e-18 64.0 0.1 1.2 1 0 0 1 1 1 1 LSM domain CAP_GLY PF01302.20 CDF91962.1 - 2.9e-19 68.5 0.4 4.3e-19 67.9 0.3 1.3 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.1 CDF91962.1 - 1.3e-08 34.9 0.0 2.2e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain PGA2 PF07543.7 CDF91963.1 - 6.2e-14 51.9 4.1 3.2e-07 30.2 0.0 2.0 1 1 1 2 2 2 2 Protein trafficking PGA2 DUF2852 PF11014.3 CDF91963.1 - 0.0027 17.6 0.1 0.0038 17.1 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2852) DivIC PF04977.10 CDF91963.1 - 0.17 11.4 2.0 1.4 8.4 0.0 2.2 2 0 0 2 2 2 0 Septum formation initiator RNA_pol_3_Rpc31 PF11705.3 CDF91964.1 - 2e-66 224.2 13.1 2.2e-66 224.1 9.1 1.0 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 C2 PF00168.25 CDF91965.1 - 0.0035 17.1 0.0 0.0066 16.2 0.0 1.5 1 0 0 1 1 1 1 C2 domain Tho2 PF11262.3 CDF91966.1 - 1.1e-53 182.3 6.9 1.1e-53 182.3 4.8 3.4 4 1 0 4 4 4 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.3 CDF91966.1 - 6.2e-27 93.1 0.4 1.9e-26 91.6 0.3 1.9 1 0 0 1 1 1 1 Transcription- and export-related complex subunit SF3b10 PF07189.6 CDF91967.1 - 1.7e-25 88.5 0.7 2.2e-25 88.2 0.5 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) LANC_like PF05147.8 CDF91967.1 - 0.033 12.7 0.1 0.033 12.7 0.0 1.1 1 0 0 1 1 1 0 Lanthionine synthetase C-like protein CAP_N PF01213.14 CDF91969.1 - 8.1e-102 340.6 3.0 1e-101 340.3 2.1 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.6 CDF91969.1 - 7.8e-57 191.0 1.0 1.3e-56 190.3 0.7 1.4 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal S4 PF01479.20 CDF91970.1 - 2.6e-15 55.5 0.0 5.5e-15 54.5 0.0 1.6 1 0 0 1 1 1 1 S4 domain CtIP_N PF10482.4 CDF91970.1 - 0.036 13.8 2.6 0.45 10.2 0.2 2.4 2 0 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain S4_2 PF13275.1 CDF91970.1 - 0.042 13.4 0.0 0.099 12.2 0.0 1.6 1 0 0 1 1 1 0 S4 domain LTXXQ PF07813.7 CDF91970.1 - 0.052 13.9 1.0 0.17 12.3 0.7 1.8 1 0 0 1 1 1 0 LTXXQ motif family protein Eaf7 PF07904.8 CDF91971.1 - 4.5e-30 103.4 0.4 8.9e-30 102.5 0.3 1.5 1 0 0 1 1 1 1 Chromatin modification-related protein EAF7 DUF605 PF04652.11 CDF91971.1 - 0.99 8.7 16.5 1.2 8.4 11.4 1.1 1 0 0 1 1 1 0 Vta1 like FKBP_C PF00254.23 CDF91972.1 - 6.1e-33 112.7 0.0 7.1e-33 112.4 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase ADH_zinc_N PF00107.21 CDF91973.1 - 6.9e-13 48.2 0.0 1.2e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 CDF91973.1 - 1.5e-06 27.9 0.2 1.9e-05 24.3 0.1 2.3 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain TauD PF02668.11 CDF91976.1 - 1.3e-50 172.5 0.9 1.8e-50 172.0 0.6 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family RrnaAD PF00398.15 CDF91977.1 - 1.1e-64 218.0 0.0 1.2e-64 217.8 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_26 PF13659.1 CDF91977.1 - 9.5e-11 41.7 0.0 1.5e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 CDF91977.1 - 2.9e-06 27.8 0.0 4.9e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 CDF91977.1 - 9.6e-05 21.8 0.0 0.00016 21.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.1 CDF91977.1 - 0.00019 21.1 0.0 0.00026 20.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 CDF91977.1 - 0.00047 20.5 0.0 0.0011 19.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 CDF91977.1 - 0.00051 20.4 0.0 0.0012 19.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 CDF91977.1 - 0.00065 18.9 0.1 0.002 17.3 0.0 1.7 2 0 0 2 2 2 1 O-methyltransferase CMAS PF02353.15 CDF91977.1 - 0.0016 17.5 0.0 0.0056 15.8 0.0 1.7 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase PCMT PF01135.14 CDF91977.1 - 0.0017 17.9 0.0 0.0028 17.2 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 CDF91977.1 - 0.0027 17.3 0.0 0.0047 16.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.7 CDF91977.1 - 0.062 12.1 0.0 0.11 11.3 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Ubie_methyltran PF01209.13 CDF91977.1 - 0.093 11.8 0.1 0.19 10.8 0.0 1.5 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_28 PF02636.12 CDF91977.1 - 0.15 11.4 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase PI-PLC-X PF00388.14 CDF91979.1 - 1.7e-46 157.2 0.0 7.5e-46 155.1 0.0 2.1 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.14 CDF91979.1 - 1.1e-37 128.6 0.1 3.7e-37 126.8 0.1 1.9 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.6 CDF91979.1 - 7.7e-08 32.2 0.1 3e-07 30.3 0.0 2.1 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_1 PF00036.27 CDF91979.1 - 1.6e-05 23.8 0.1 0.00011 21.2 0.0 2.4 2 0 0 2 2 2 1 EF hand C2 PF00168.25 CDF91979.1 - 4.1e-05 23.3 0.0 0.00019 21.1 0.0 2.1 2 0 0 2 2 2 1 C2 domain EF-hand_7 PF13499.1 CDF91979.1 - 9.6e-05 22.4 3.2 0.00026 21.0 0.1 2.8 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.1 CDF91979.1 - 0.00044 19.8 1.8 0.13 11.8 0.1 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.1 CDF91979.1 - 0.002 17.4 0.2 0.005 16.1 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.1 CDF91979.1 - 0.022 14.6 1.6 0.12 12.3 0.1 3.1 4 0 0 4 4 4 0 EF-hand domain KAR9 PF08580.5 CDF91980.1 - 2.5e-97 326.8 21.7 4.7e-97 325.9 15.0 1.3 1 1 0 1 1 1 1 Yeast cortical protein KAR9 MscS_porin PF12795.2 CDF91980.1 - 0.24 10.6 10.7 3.1 7.0 2.7 3.2 3 0 0 3 3 3 0 Mechanosensitive ion channel porin domain CCDC92 PF14916.1 CDF91980.1 - 1.2 8.7 7.5 0.39 10.3 1.8 2.7 2 1 0 2 2 2 0 Coiled-coil domain of unknown function Syntaxin-6_N PF09177.6 CDF91980.1 - 1.4 9.3 8.1 1.1 9.6 0.1 4.0 3 1 2 5 5 5 0 Syntaxin 6, N-terminal DUF904 PF06005.7 CDF91980.1 - 5.7 7.3 11.4 3.3 8.0 3.4 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF904) ABC_membrane PF00664.18 CDF91981.1 - 1.3e-51 175.6 2.6 1.7e-51 175.2 1.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.22 CDF91981.1 - 1.2e-33 116.2 0.0 3.8e-33 114.6 0.0 1.9 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.14 CDF91981.1 - 0.00017 20.8 0.0 0.0052 16.0 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 CDF91981.1 - 0.00036 20.5 0.0 0.22 11.4 0.0 2.4 1 1 1 2 2 2 2 AAA domain AAA_10 PF12846.2 CDF91981.1 - 0.0015 18.0 0.1 0.13 11.6 0.0 2.3 2 0 0 2 2 2 1 AAA-like domain ABC_ATPase PF09818.4 CDF91981.1 - 0.0021 16.7 0.1 0.0049 15.4 0.0 1.6 2 0 0 2 2 2 1 Predicted ATPase of the ABC class IstB_IS21 PF01695.12 CDF91981.1 - 0.0062 15.9 0.0 0.28 10.5 0.0 2.6 2 1 1 3 3 3 1 IstB-like ATP binding protein AAA_29 PF13555.1 CDF91981.1 - 0.0066 15.9 0.0 0.029 13.9 0.0 2.1 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.1 CDF91981.1 - 0.0096 15.9 0.1 0.049 13.6 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_17 PF13207.1 CDF91981.1 - 0.01 16.6 0.0 0.022 15.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.1 CDF91981.1 - 0.013 14.8 0.0 0.093 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.1 CDF91981.1 - 0.029 14.4 0.1 0.52 10.4 0.0 2.6 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.9 CDF91981.1 - 0.037 13.7 0.0 0.14 11.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DEAD PF00270.24 CDF91981.1 - 0.048 13.1 0.0 9.5 5.6 0.0 2.8 3 0 0 3 3 3 0 DEAD/DEAH box helicase AAA PF00004.24 CDF91981.1 - 0.056 13.6 0.0 0.4 10.8 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.1 CDF91981.1 - 0.094 12.6 0.0 1 9.2 0.0 2.6 3 0 0 3 3 3 0 AAA domain DUF258 PF03193.11 CDF91981.1 - 0.14 11.3 0.0 0.38 9.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF258 ATP-synt_Eps PF04627.8 CDF91982.1 - 3.5e-22 77.7 0.7 3.9e-22 77.5 0.5 1.0 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain DNA_pol_phi PF04931.8 CDF91983.1 - 1.6e-132 442.9 30.0 1.6e-132 442.9 20.8 1.4 2 0 0 2 2 2 1 DNA polymerase phi PGM_PMM_I PF02878.11 CDF91984.1 - 2.6e-14 52.8 0.0 4.7e-08 32.6 0.0 2.5 2 0 0 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 CDF91984.1 - 1.3e-11 44.7 0.0 6.6e-11 42.4 0.0 2.2 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 CDF91984.1 - 3.3e-09 36.6 0.1 1.1e-08 34.8 0.1 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Mitochondr_Som1 PF11093.3 CDF91985.1 - 3.5e-21 74.7 1.6 4.3e-21 74.5 1.1 1.1 1 0 0 1 1 1 1 Mitochondrial export protein Som1 DUF2145 PF09916.4 CDF91985.1 - 0.061 12.8 0.0 0.061 12.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2145) HIM1 PF08732.5 CDF91986.1 - 1.9e-84 283.5 0.1 2.2e-84 283.2 0.1 1.0 1 0 0 1 1 1 1 HIM1 BOP1NT PF08145.7 CDF91987.1 - 2.3e-104 348.7 8.1 4.9e-104 347.6 5.6 1.6 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.27 CDF91987.1 - 1.7e-25 87.9 7.5 1.9e-11 43.3 0.1 7.1 7 0 0 7 7 7 3 WD domain, G-beta repeat SDA1 PF05285.7 CDF91987.1 - 6 6.0 26.9 25 4.0 15.7 2.5 2 0 0 2 2 2 0 SDA1 Swi3 PF07962.7 CDF91988.1 - 2.8e-23 81.3 0.1 4.4e-23 80.7 0.1 1.3 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 RVT_thumb PF06817.9 CDF91988.1 - 0.069 12.7 0.0 0.24 10.9 0.0 1.8 2 0 0 2 2 2 0 Reverse transcriptase thumb domain DUF4147 PF13660.1 CDF91988.1 - 0.081 12.0 0.1 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4147) Nucleoporin_FG PF13634.1 CDF91989.1 - 1.9e-56 189.1 430.0 2.8e-13 50.0 29.9 13.0 2 1 7 9 9 9 7 Nucleoporin FG repeat region Nucleoporin2 PF04096.9 CDF91989.1 - 3.7e-46 156.4 0.0 6.5e-46 155.6 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin autopeptidase PWWP PF00855.12 CDF91990.1 - 3.4e-22 78.4 0.8 8.3e-22 77.1 0.6 1.7 1 0 0 1 1 1 1 PWWP domain MIP-T3 PF10243.4 CDF91990.1 - 0.0073 14.8 22.1 0.01 14.3 15.3 1.2 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 Daxx PF03344.10 CDF91990.1 - 0.14 10.6 21.3 0.18 10.2 14.8 1.1 1 0 0 1 1 1 0 Daxx Family SAPS PF04499.10 CDF91990.1 - 2.5 6.6 8.5 3.2 6.2 5.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF1510 PF07423.6 CDF91990.1 - 4.9 6.4 18.3 9.9 5.4 12.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Pex16 PF08610.5 CDF91990.1 - 8.8 5.2 10.8 13 4.6 7.5 1.2 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) SRF-TF PF00319.13 CDF91991.1 - 2.3e-25 87.5 0.3 3.1e-25 87.1 0.2 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) CDV3 PF15359.1 CDF91991.1 - 0.015 15.3 2.1 0.025 14.6 1.5 1.3 1 0 0 1 1 1 0 Carnitine deficiency-associated protein 3 TFIIA PF03153.8 CDF91991.1 - 8.1 6.2 10.0 9.7 5.9 6.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SRF-TF PF00319.13 CDF91992.1 - 2.2e-24 84.4 0.2 2.8e-24 84.0 0.1 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) NDK PF00334.14 CDF91993.1 - 4e-57 191.7 0.0 4.5e-57 191.5 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Aldo_ket_red PF00248.16 CDF91995.1 - 3e-45 154.2 0.0 3.6e-45 153.9 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Bap31 PF05529.7 CDF91996.1 - 6.5e-46 156.2 0.0 8.8e-46 155.7 0.0 1.2 1 0 0 1 1 1 1 B-cell receptor-associated protein 31-like Sec2p PF06428.6 CDF91996.1 - 0.025 14.4 1.6 0.035 13.9 1.1 1.3 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p DUF4047 PF13256.1 CDF91996.1 - 0.15 12.0 1.1 0.26 11.2 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) PC4 PF02229.11 CDF91997.1 - 3.1e-20 71.1 0.0 5.4e-20 70.3 0.0 1.4 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) SPX PF03105.14 CDF91997.1 - 2.9 7.6 9.2 4.3 7.0 2.1 2.2 1 1 1 2 2 2 0 SPX domain CorA PF01544.13 CDF91998.1 - 6.7e-39 133.6 7.3 4.9e-20 71.7 0.4 3.3 3 0 0 3 3 3 3 CorA-like Mg2+ transporter protein A_thal_3526 PF09713.5 CDF91998.1 - 0.13 12.3 0.1 0.54 10.4 0.0 2.1 2 0 0 2 2 2 0 Plant protein 1589 of unknown function (A_thal_3526) zf-C2H2 PF00096.21 CDF92000.1 - 1.8e-10 40.5 13.7 1.1e-05 25.4 2.6 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 CDF92000.1 - 9.1e-09 35.0 13.0 0.00012 22.1 2.4 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.1 CDF92000.1 - 5.7e-08 32.6 18.7 9.1e-07 28.8 1.8 3.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-BED PF02892.10 CDF92000.1 - 8.3e-06 25.4 3.5 0.025 14.3 0.4 2.7 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_jaz PF12171.3 CDF92000.1 - 0.00025 21.0 10.4 0.067 13.3 2.6 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding GAGA PF09237.6 CDF92000.1 - 0.042 13.4 1.8 0.67 9.5 0.1 2.4 1 1 1 2 2 2 0 GAGA factor zf-Di19 PF05605.7 CDF92000.1 - 0.12 12.5 4.0 0.23 11.6 2.7 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.1 CDF92000.1 - 0.18 11.7 10.0 1.1 9.2 1.8 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger DUF629 PF04780.7 CDF92000.1 - 0.29 9.5 8.4 0.11 11.0 0.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF629) zf-C2H2_2 PF12756.2 CDF92000.1 - 0.44 10.6 8.3 0.86 9.7 1.4 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.2 CDF92000.1 - 3 8.1 13.5 1.1 9.5 1.4 2.7 3 0 0 3 3 2 0 Zinc-finger of C2H2 type Pkinase PF00069.20 CDF92001.1 - 1.6e-43 148.7 0.0 3.3e-43 147.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 CDF92001.1 - 1.2e-20 73.6 0.0 1.5e-19 70.1 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.1 CDF92001.1 - 4e-05 22.7 0.0 0.00015 20.8 0.0 1.9 1 1 0 1 1 1 1 Kinase-like APH PF01636.18 CDF92001.1 - 0.00068 19.4 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Rhodanese PF00581.15 CDF92002.1 - 2.6e-11 43.8 0.0 6.1e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Peptidase_S24 PF00717.18 CDF92003.1 - 3.7e-05 23.2 0.0 0.00011 21.7 0.0 1.8 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.4 CDF92003.1 - 9.3e-05 21.9 0.0 0.00066 19.2 0.0 2.1 1 1 1 2 2 2 1 Signal peptidase, peptidase S26 DUF4137 PF13593.1 CDF92004.1 - 7.5e-108 360.3 14.4 8.8e-108 360.0 10.0 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) E1-E2_ATPase PF00122.15 CDF92004.1 - 3.4 6.6 4.7 2.3 7.1 0.6 2.4 3 0 0 3 3 3 0 E1-E2 ATPase Actin PF00022.14 CDF92005.1 - 4.9e-24 84.4 0.0 3e-23 81.8 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.8 CDF92005.1 - 0.00059 18.5 0.1 0.51 8.8 0.0 2.8 3 0 0 3 3 3 2 MreB/Mbl protein FtsA PF14450.1 CDF92005.1 - 0.024 14.4 0.2 0.095 12.5 0.1 1.9 2 1 0 2 2 2 0 Cell division protein FtsA Histone PF00125.19 CDF92006.1 - 1.4e-27 95.6 1.5 2.5e-27 94.7 0.6 1.8 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 CDF92006.1 - 0.0045 17.1 0.1 0.0097 16.0 0.1 1.5 1 0 0 1 1 1 1 Kinetochore component CENP-S FCH PF00611.18 CDF92007.1 - 4e-20 71.7 0.5 2.5e-19 69.2 0.0 2.6 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.1 CDF92007.1 - 0.00053 19.5 0.0 0.0011 18.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.23 CDF92007.1 - 0.00053 19.3 0.0 0.0011 18.3 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.12 CDF92007.1 - 0.0044 16.4 0.0 0.01 15.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain DUF3812 PF12757.2 CDF92008.1 - 2.3e-24 85.7 0.5 2.3e-24 85.7 0.3 4.7 4 1 0 4 4 4 1 Protein of unknown function (DUF3812) Frag1 PF10277.4 CDF92009.1 - 9.2e-72 240.9 20.5 1.1e-71 240.7 14.2 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF872 PF05915.7 CDF92009.1 - 0.043 13.6 0.5 0.75 9.6 0.0 2.5 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) Peptidase_M20 PF01546.23 CDF92010.1 - 5.9e-25 87.8 0.0 7.8e-25 87.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 CDF92010.1 - 6.9e-12 45.1 0.1 1.3e-11 44.2 0.1 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain KilA-N PF04383.8 CDF92013.1 - 0.00043 19.8 0.0 0.0025 17.4 0.0 2.0 1 1 0 1 1 1 1 KilA-N domain Fungal_trans PF04082.13 CDF92014.1 - 3.5e-18 65.4 8.4 3.5e-18 65.4 5.8 2.2 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.13 CDF92014.1 - 2.1e-08 33.9 11.6 2.1e-08 33.9 8.0 2.4 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DNA_primase_lrg PF04104.9 CDF92015.1 - 2.7e-86 289.0 0.1 6e-86 287.9 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Amino_oxidase PF01593.19 CDF92016.1 - 3.6e-63 214.2 0.3 5.6e-62 210.2 0.2 2.4 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 CDF92016.1 - 2.1e-12 46.8 0.4 5.5e-12 45.5 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 CDF92016.1 - 5.1e-11 43.0 0.1 5.1e-06 26.6 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 CDF92016.1 - 6.8e-09 35.0 0.2 1.2e-05 24.3 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 CDF92016.1 - 3.4e-05 22.8 1.6 5e-05 22.3 1.1 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.14 CDF92016.1 - 4.7e-05 22.6 0.5 7.3e-05 21.9 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 CDF92016.1 - 0.00038 20.3 0.1 0.0049 16.7 0.0 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 CDF92016.1 - 0.0012 17.9 0.4 0.0019 17.3 0.3 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.9 CDF92016.1 - 0.031 12.7 1.8 0.1 11.0 0.6 2.0 2 0 0 2 2 2 0 HI0933-like protein SecA_PP_bind PF01043.15 CDF92016.1 - 0.046 14.0 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 SecA preprotein cross-linking domain GIDA PF01134.17 CDF92016.1 - 0.071 11.9 1.7 0.092 11.5 0.7 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.16 CDF92016.1 - 0.13 11.8 0.1 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ApbA PF02558.11 CDF92016.1 - 0.14 11.5 1.8 5.9 6.3 0.0 2.4 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.22 CDF92016.1 - 0.18 12.2 0.7 0.48 10.8 0.5 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.15 CDF92016.1 - 0.19 11.8 0.4 0.35 10.9 0.3 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.1 CDF92016.1 - 0.22 11.2 0.7 3.4 7.4 0.2 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Copper-fist PF00649.13 CDF92017.1 - 1.6e-20 72.0 5.9 1.6e-20 72.0 4.1 2.3 3 0 0 3 3 3 1 Copper fist DNA binding domain UQ_con PF00179.21 CDF92018.1 - 2.1e-49 166.5 0.0 2.3e-49 166.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.17 CDF92018.1 - 0.045 13.6 2.5 0.14 12.0 1.7 2.1 1 1 0 1 1 1 0 RWD domain Prok-E2_B PF14461.1 CDF92018.1 - 0.12 12.1 0.1 0.2 11.3 0.1 1.6 1 1 0 1 1 1 0 Prokaryotic E2 family B Glyco_hydro_76 PF03663.9 CDF92019.1 - 1.7e-146 488.3 29.9 2.2e-146 487.9 20.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 DUF2347 PF09804.4 CDF92020.1 - 5.6e-68 229.2 0.0 7e-68 228.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.1 CDF92020.1 - 2.1e-17 63.7 4.5 2.6e-07 30.9 2.0 3.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4484) Avl9 PF09794.4 CDF92020.1 - 0.00014 20.5 0.1 0.00055 18.5 0.0 1.9 2 0 0 2 2 2 1 Transport protein Avl9 SPA PF08616.5 CDF92020.1 - 0.045 13.4 0.0 0.087 12.5 0.0 1.4 1 0 0 1 1 1 0 Stabilization of polarity axis Hrs_helical PF12210.3 CDF92021.1 - 0.009 16.2 1.7 0.021 15.0 1.0 1.8 1 1 1 2 2 2 1 Hepatocyte growth factor-regulated tyrosine kinase substrate MerR-DNA-bind PF09278.6 CDF92021.1 - 0.063 13.6 1.8 0.13 12.6 1.2 1.5 1 0 0 1 1 1 0 MerR, DNA binding BLOC1_2 PF10046.4 CDF92021.1 - 0.16 12.1 7.3 0.32 11.1 5.0 1.6 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3417 PF11897.3 CDF92021.1 - 0.23 11.4 3.9 1.3 9.0 1.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3417) Fib_alpha PF08702.5 CDF92021.1 - 0.27 11.3 2.9 0.26 11.4 1.2 1.4 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Synaphin PF05835.7 CDF92021.1 - 0.33 11.1 5.1 0.37 10.9 3.5 1.1 1 0 0 1 1 1 0 Synaphin protein DALR_1 PF05746.10 CDF92021.1 - 0.34 10.8 3.4 0.59 10.1 2.3 1.4 1 1 0 1 1 1 0 DALR anticodon binding domain V_ATPase_I PF01496.14 CDF92021.1 - 0.46 8.2 4.2 0.5 8.1 2.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF848 PF05852.6 CDF92021.1 - 0.78 9.5 9.9 1.4 8.7 5.0 2.0 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Streptin-Immun PF11083.3 CDF92021.1 - 0.87 9.6 6.0 1.1 9.2 2.3 2.0 1 1 1 2 2 2 0 Lantibiotic streptin immunity protein DUF4463 PF14703.1 CDF92021.1 - 1.5 9.3 5.1 1.3 9.5 1.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4463) APG6 PF04111.7 CDF92021.1 - 1.8 7.5 10.0 2.3 7.2 6.9 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 AAA_23 PF13476.1 CDF92021.1 - 3.3 7.9 9.2 3.8 7.7 6.4 1.1 1 0 0 1 1 1 0 AAA domain DUF4404 PF14357.1 CDF92021.1 - 7.2 7.1 9.0 7.8 6.9 0.5 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4404) TrmE_N PF10396.4 CDF92022.1 - 1.4e-35 121.6 0.0 7.1e-35 119.4 0.0 2.2 3 0 0 3 3 2 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.18 CDF92022.1 - 1.4e-23 83.0 0.2 4e-23 81.5 0.1 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTPase_Cys_C PF12631.2 CDF92022.1 - 6e-18 65.0 0.3 4.6e-17 62.1 0.0 2.6 2 1 1 3 3 3 1 Catalytic cysteine-containing C-terminus of GTPase, MnmE FeoB_N PF02421.13 CDF92022.1 - 2.1e-12 46.5 0.3 3.6e-12 45.8 0.2 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 CDF92022.1 - 3.1e-10 39.7 0.1 7.1e-09 35.3 0.0 2.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.18 CDF92022.1 - 3.6e-08 33.3 0.9 0.00015 21.6 0.1 2.5 1 1 1 2 2 2 2 Dynamin family Arf PF00025.16 CDF92022.1 - 5.1e-08 32.3 0.5 6.3e-07 28.7 0.3 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family Miro PF08477.8 CDF92022.1 - 1e-05 25.9 0.0 3.1e-05 24.4 0.0 1.9 1 0 0 1 1 1 1 Miro-like protein Ras PF00071.17 CDF92022.1 - 2.8e-05 23.5 0.0 0.00016 21.0 0.0 2.2 2 1 0 2 2 2 1 Ras family AIG1 PF04548.11 CDF92022.1 - 3.4e-05 23.0 0.2 6.7e-05 22.0 0.1 1.5 1 0 0 1 1 1 1 AIG1 family PduV-EutP PF10662.4 CDF92022.1 - 6.9e-05 22.3 0.0 0.41 10.1 0.0 2.5 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation ArgK PF03308.11 CDF92022.1 - 0.00044 19.1 0.9 0.039 12.7 0.0 2.8 2 1 1 3 3 3 1 ArgK protein DUF258 PF03193.11 CDF92022.1 - 0.00065 18.9 0.1 0.0016 17.6 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF258 G-alpha PF00503.15 CDF92022.1 - 0.0015 17.2 3.9 0.0071 15.0 0.2 3.0 2 1 2 4 4 4 1 G-protein alpha subunit CofC PF01983.11 CDF92022.1 - 0.0049 15.8 4.9 0.71 8.7 0.0 3.4 3 0 0 3 3 3 1 Guanylyl transferase CofC like AAA_22 PF13401.1 CDF92022.1 - 0.015 15.4 0.2 0.16 12.0 0.0 2.6 1 1 1 2 2 2 0 AAA domain AAA PF00004.24 CDF92022.1 - 0.016 15.4 0.3 0.28 11.3 0.0 2.7 2 1 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.1 CDF92022.1 - 0.02 14.8 0.2 0.02 14.8 0.1 1.8 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.22 CDF92022.1 - 0.023 15.0 0.1 0.075 13.3 0.0 1.9 2 0 0 2 2 1 0 ABC transporter AAA_17 PF13207.1 CDF92022.1 - 0.03 15.1 0.2 0.15 12.9 0.1 2.3 1 1 0 1 1 1 0 AAA domain AAA_10 PF12846.2 CDF92022.1 - 0.031 13.7 0.2 0.36 10.2 0.0 2.4 2 1 0 2 2 2 0 AAA-like domain PPV_E1_C PF00519.12 CDF92022.1 - 0.037 12.6 0.0 0.057 12.0 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase AAA_16 PF13191.1 CDF92022.1 - 0.059 13.3 0.1 0.53 10.2 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_28 PF13521.1 CDF92022.1 - 0.091 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Flavodoxin_3 PF12641.2 CDF92022.1 - 0.16 11.3 0.1 0.34 10.3 0.1 1.4 1 0 0 1 1 1 0 Flavodoxin domain KTI12 PF08433.5 CDF92022.1 - 0.37 9.9 2.2 12 5.0 0.1 2.5 3 0 0 3 3 3 0 Chromatin associated protein KTI12 Pex2_Pex12 PF04757.9 CDF92024.1 - 5.2e-37 127.4 8.8 6.3e-37 127.1 6.1 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.1 CDF92024.1 - 0.00075 19.4 8.0 0.0013 18.7 5.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.1 CDF92024.1 - 0.00078 19.0 4.7 0.0012 18.4 3.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rad50_zn_hook PF04423.9 CDF92024.1 - 0.25 10.8 10.0 4.1 6.9 0.1 3.3 3 0 0 3 3 3 0 Rad50 zinc hook motif zf-C3HC4_4 PF15227.1 CDF92024.1 - 0.71 9.8 10.4 1.3 8.9 7.2 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.1 CDF92024.1 - 1.1 9.1 7.3 2 8.3 5.1 1.4 1 0 0 1 1 1 0 Ring finger domain F_bP_aldolase PF01116.15 CDF92025.1 - 2.3e-94 315.7 0.0 2.6e-94 315.5 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II DUF89 PF01937.14 CDF92026.1 - 1.4e-116 389.1 1.7 1.6e-116 389.0 1.2 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 DWNN PF08783.6 CDF92027.1 - 2.5e-34 117.0 1.4 1.7e-33 114.3 0.1 2.3 2 0 0 2 2 2 1 DWNN domain zf-Nse PF11789.3 CDF92027.1 - 7.1e-05 22.2 0.9 0.00016 21.1 0.6 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.10 CDF92027.1 - 0.00049 19.9 0.0 0.00097 19.0 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-CCHC_2 PF13696.1 CDF92027.1 - 0.0012 18.3 6.1 0.0017 17.8 3.0 2.1 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.18 CDF92027.1 - 0.0023 17.7 2.7 0.0023 17.7 1.9 2.8 4 0 0 4 4 4 1 Zinc knuckle Rubredoxin PF00301.15 CDF92027.1 - 0.0025 17.6 1.6 2.8 7.9 0.0 3.2 3 0 0 3 3 3 2 Rubredoxin Zn_Tnp_IS1595 PF12760.2 CDF92027.1 - 0.0099 15.6 0.3 0.53 10.1 0.0 2.4 2 0 0 2 2 2 1 Transposase zinc-ribbon domain zf-CCHC_3 PF13917.1 CDF92027.1 - 0.064 12.9 0.1 0.13 11.9 0.1 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-MIZ PF02891.15 CDF92027.1 - 0.28 10.7 1.9 0.77 9.3 1.3 1.8 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger zf-CCHC_5 PF14787.1 CDF92027.1 - 0.81 9.2 4.8 0.1 12.0 0.3 1.8 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger TFIIA_gamma_C PF02751.9 CDF92028.1 - 2e-27 94.7 0.0 2.8e-27 94.2 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.11 CDF92028.1 - 1.2e-24 85.5 0.1 1.6e-24 85.1 0.1 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TAP42 PF04177.7 CDF92029.1 - 6.4e-91 304.8 24.4 7.2e-91 304.6 16.9 1.0 1 0 0 1 1 1 1 TAP42-like family Nup160 PF11715.3 CDF92030.1 - 2.5e-19 68.8 0.8 5.6e-19 67.6 0.6 1.5 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Striatin PF08232.7 CDF92031.1 - 8e-25 87.7 11.0 9.1e-24 84.2 0.8 3.2 2 1 1 3 3 3 2 Striatin family ComX PF05952.7 CDF92031.1 - 0.0025 17.2 1.4 0.12 11.8 0.1 3.3 2 1 0 2 2 2 1 Bacillus competence pheromone ComX Herpes_BLRF2 PF05812.7 CDF92031.1 - 0.022 14.5 0.3 0.052 13.3 0.2 1.6 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein 5_nucleotid_C PF02872.13 CDF92031.1 - 0.024 14.5 0.0 7.4 6.5 0.0 2.3 2 0 0 2 2 2 0 5'-nucleotidase, C-terminal domain Mto2_bdg PF12808.2 CDF92031.1 - 0.034 14.2 0.9 0.083 13.0 0.6 1.6 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region TCTP PF00838.12 CDF92032.1 - 5.3e-70 234.6 0.5 6e-70 234.4 0.3 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein adh_short PF00106.20 CDF92033.1 - 1.4e-15 57.5 0.2 2.9e-08 33.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.1 CDF92033.1 - 3.5e-09 36.8 2.4 3.2e-08 33.6 1.7 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 CDF92033.1 - 0.022 14.4 0.8 0.31 10.6 0.1 2.9 2 2 0 2 2 2 0 KR domain Epimerase PF01370.16 CDF92033.1 - 0.056 12.8 0.0 0.96 8.8 0.0 2.0 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CDF92033.1 - 0.063 13.2 0.1 0.1 12.6 0.1 1.3 1 0 0 1 1 1 0 NADH(P)-binding CUE PF02845.11 CDF92034.1 - 0.016 14.6 0.1 0.033 13.6 0.1 1.6 1 0 0 1 1 1 0 CUE domain Vpu PF00558.14 CDF92034.1 - 0.17 11.4 1.4 0.56 9.8 1.0 1.8 1 0 0 1 1 1 0 Vpu protein UPF0203 PF05254.7 CDF92036.1 - 5.3e-30 103.0 3.8 6.1e-30 102.8 2.6 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) Cmc1 PF08583.5 CDF92036.1 - 0.011 15.5 2.7 0.32 10.8 0.2 2.2 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like UCR_hinge PF02320.11 CDF92036.1 - 0.011 15.6 2.8 0.034 14.0 1.9 1.7 1 1 0 1 1 1 0 Ubiquinol-cytochrome C reductase hinge protein COX6B PF02297.12 CDF92036.1 - 0.065 13.2 5.8 2.1 8.4 0.2 2.1 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb ApbA_C PF08546.6 CDF92040.1 - 1.4e-31 109.0 0.0 1.1e-30 106.2 0.0 2.1 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.11 CDF92040.1 - 2.3e-26 92.0 0.0 3e-26 91.6 0.0 1.1 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA CagE_TrbE_VirB PF03135.9 CDF92040.1 - 0.13 11.9 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 CagE, TrbE, VirB family, component of type IV transporter system Ribonuc_L-PSP PF01042.16 CDF92042.1 - 3.5e-25 88.1 0.0 4.2e-25 87.8 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Aminotran_3 PF00202.16 CDF92043.1 - 3.7e-58 197.0 0.0 4.6e-58 196.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III FMN_dh PF01070.13 CDF92044.1 - 2e-94 316.3 0.0 1.3e-93 313.7 0.0 1.9 1 1 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.23 CDF92044.1 - 4.2e-20 71.3 0.0 9.8e-20 70.1 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.12 CDF92044.1 - 8.9e-10 38.0 0.0 1.8e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.20 CDF92044.1 - 0.00023 20.1 0.3 0.0025 16.7 0.1 2.1 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.10 CDF92044.1 - 0.0056 15.8 0.1 0.025 13.7 0.0 2.0 2 0 0 2 2 2 1 Nitronate monooxygenase His_biosynth PF00977.16 CDF92044.1 - 0.038 13.2 0.0 5.4 6.2 0.0 2.3 2 0 0 2 2 2 0 Histidine biosynthesis protein AA_permease PF00324.16 CDF92045.1 - 9.8e-102 340.7 36.6 1.2e-101 340.4 25.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.1 CDF92045.1 - 5.6e-25 87.7 38.4 7.5e-25 87.3 26.6 1.1 1 0 0 1 1 1 1 Amino acid permease adh_short_C2 PF13561.1 CDF92047.1 - 3.5e-19 69.5 0.0 4.2e-19 69.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 CDF92047.1 - 1.3e-17 64.1 0.0 1.6e-17 63.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 CDF92047.1 - 1.2e-10 41.3 0.0 1.8e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 KR domain His_Phos_2 PF00328.17 CDF92049.1 - 1.4e-48 166.0 0.0 1.7e-48 165.7 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Epimerase PF01370.16 CDF92050.1 - 2.5e-13 50.0 0.0 1.5e-08 34.3 0.0 2.0 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 CDF92050.1 - 3e-12 46.9 0.0 4.4e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 NADH(P)-binding 3Beta_HSD PF01073.14 CDF92050.1 - 4.8e-10 38.6 0.0 3.9e-08 32.3 0.0 2.1 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.8 CDF92050.1 - 1.3e-05 24.6 0.0 2e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.7 CDF92050.1 - 0.00025 20.0 0.0 0.0015 17.5 0.0 2.3 1 1 0 2 2 2 1 Male sterility protein RmlD_sub_bind PF04321.12 CDF92050.1 - 0.00036 19.5 0.0 0.032 13.1 0.0 2.2 2 0 0 2 2 2 2 RmlD substrate binding domain adh_short PF00106.20 CDF92050.1 - 0.0011 18.8 0.0 0.0019 18.1 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase F420_oxidored PF03807.12 CDF92050.1 - 0.0025 18.1 0.1 0.0062 16.9 0.1 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.15 CDF92050.1 - 0.0041 17.0 0.1 0.0078 16.1 0.0 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Polysacc_synt_2 PF02719.10 CDF92050.1 - 0.12 11.1 0.1 0.18 10.6 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Amidase PF01425.16 CDF92055.1 - 0.018 13.9 0.0 0.026 13.4 0.0 1.2 1 0 0 1 1 1 0 Amidase MFS_1 PF07690.11 CDF92056.1 - 9e-18 64.0 23.0 9e-18 64.0 15.9 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily IL32 PF15225.1 CDF92056.1 - 0.018 14.9 0.1 0.04 13.8 0.1 1.5 1 0 0 1 1 1 0 Interleukin 32 DUF2852 PF11014.3 CDF92056.1 - 0.065 13.1 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) DUF1228 PF06779.9 CDF92056.1 - 0.076 13.0 2.8 0.076 13.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1228) Plant_NMP1 PF06694.6 CDF92056.1 - 0.1 11.5 0.1 0.15 10.9 0.1 1.2 1 0 0 1 1 1 0 Plant nuclear matrix protein 1 (NMP1) DUF3353 PF11833.3 CDF92056.1 - 2.2 7.7 5.9 0.68 9.3 0.9 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3353) OPT PF03169.10 CDF92057.1 - 1.2e-153 512.9 45.6 1.4e-153 512.6 31.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Sulfatase PF00884.18 CDF92059.1 - 1.2e-37 129.7 0.0 1.6e-37 129.3 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.17 CDF92059.1 - 0.03 13.6 0.0 0.48 9.6 0.0 2.2 2 0 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.13 CDF92059.1 - 0.067 12.5 0.0 0.47 9.7 0.0 2.1 2 0 0 2 2 2 0 Metalloenzyme superfamily ABC2_membrane PF01061.19 CDF92062.1 - 8.9e-82 273.3 62.1 2.8e-43 147.5 18.3 2.6 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.22 CDF92062.1 - 2.5e-38 131.4 0.0 1.3e-17 64.4 0.0 3.1 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.7 CDF92062.1 - 1.6e-35 120.8 0.0 1.6e-35 120.8 0.0 3.1 3 0 0 3 3 2 1 CDR ABC transporter ABC_trans_N PF14510.1 CDF92062.1 - 5.9e-22 77.5 0.0 1.6e-21 76.1 0.0 1.8 1 0 0 1 1 1 1 ABC-transporter extracellular N-terminal AAA_25 PF13481.1 CDF92062.1 - 6.4e-08 32.2 0.0 8.9e-05 21.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 CDF92062.1 - 1.1e-06 28.8 0.3 5.4e-05 23.2 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.1 CDF92062.1 - 8e-06 25.7 0.0 0.055 13.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain cobW PF02492.14 CDF92062.1 - 1.1e-05 24.9 1.7 0.012 15.0 0.1 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain DUF258 PF03193.11 CDF92062.1 - 7.3e-05 22.0 0.0 0.004 16.3 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 ABC2_membrane_3 PF12698.2 CDF92062.1 - 0.00018 20.6 15.2 0.00018 20.6 10.5 2.9 2 1 0 2 2 2 1 ABC-2 family transporter protein AAA_17 PF13207.1 CDF92062.1 - 0.00033 21.4 0.0 0.67 10.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.1 CDF92062.1 - 0.00037 20.6 0.1 0.42 10.7 0.0 3.5 4 0 0 4 4 3 1 AAA domain AAA_19 PF13245.1 CDF92062.1 - 0.00039 20.1 0.4 0.76 9.5 0.0 2.7 2 0 0 2 2 2 2 Part of AAA domain AAA_18 PF13238.1 CDF92062.1 - 0.00044 20.5 0.0 0.18 12.0 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 CDF92062.1 - 0.00071 19.0 0.6 0.0047 16.4 0.1 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain SMC_N PF02463.14 CDF92062.1 - 0.0012 18.1 0.1 0.11 11.7 0.0 3.1 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain NACHT PF05729.7 CDF92062.1 - 0.0014 18.3 0.1 1.7 8.2 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_23 PF13476.1 CDF92062.1 - 0.0043 17.4 0.2 0.13 12.5 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.1 CDF92062.1 - 0.022 14.7 1.8 0.13 12.2 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.1 CDF92062.1 - 0.024 14.6 5.4 0.11 12.4 0.0 3.4 3 1 0 3 3 2 0 AAA domain UPF0079 PF02367.12 CDF92062.1 - 0.024 14.2 0.7 0.94 9.1 0.1 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 PduV-EutP PF10662.4 CDF92062.1 - 0.11 11.9 0.7 2.2 7.7 0.1 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.24 CDF92062.1 - 0.13 12.5 0.1 43 4.3 0.0 3.1 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.2 CDF92062.1 - 0.17 11.2 0.2 17 4.7 0.1 2.7 3 0 0 3 3 3 0 AAA-like domain NTPase_1 PF03266.10 CDF92062.1 - 0.21 11.2 0.3 29 4.3 0.1 2.9 3 0 0 3 3 3 0 NTPase AAA_30 PF13604.1 CDF92062.1 - 0.3 10.6 0.2 5.8 6.4 0.1 2.3 2 0 0 2 2 2 0 AAA domain T2SE PF00437.15 CDF92062.1 - 0.34 9.7 0.0 21 3.9 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein DUP PF00674.13 CDF92063.1 - 1e-06 28.6 1.0 1e-06 28.6 0.7 2.0 2 0 0 2 2 2 1 DUP family MNHE PF01899.11 CDF92063.1 - 1.1 8.9 5.2 1.5 8.4 3.6 1.2 1 0 0 1 1 1 0 Na+/H+ ion antiporter subunit SBF PF01758.11 CDF92066.1 - 4.4e-53 179.4 12.3 4.4e-53 179.4 8.5 2.1 3 0 0 3 3 3 1 Sodium Bile acid symporter family UL97 PF06734.7 CDF92066.1 - 0.0025 17.2 0.0 0.0046 16.3 0.0 1.4 1 0 0 1 1 1 1 UL97 DUF3464 PF11947.3 CDF92066.1 - 0.0072 15.7 0.1 0.021 14.2 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3464) Actin PF00022.14 CDF92067.1 - 4.2e-06 25.4 0.1 4.3e-06 25.3 0.1 1.0 1 0 0 1 1 1 1 Actin BNR PF02012.15 CDF92069.1 - 2.3e-10 38.6 27.2 0.31 11.0 0.2 8.5 8 0 0 8 8 8 6 BNR/Asp-box repeat BNR_2 PF13088.1 CDF92069.1 - 8.1e-06 25.3 5.4 0.21 10.8 0.0 4.6 2 1 1 3 3 3 3 BNR repeat-like domain Saw1 PF11561.3 CDF92069.1 - 0.0023 17.3 0.0 0.0037 16.6 0.0 1.3 1 0 0 1 1 1 1 Single strand annealing-weakened 1 Mo-co_dimer PF03404.11 CDF92069.1 - 0.92 9.1 5.7 14 5.3 0.0 3.9 6 0 0 6 6 6 0 Mo-co oxidoreductase dimerisation domain MFS_1 PF07690.11 CDF92071.1 - 6.9e-28 97.3 26.4 6.9e-28 97.3 18.3 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Ndc1_Nup PF09531.5 CDF92071.1 - 0.056 11.8 1.1 0.11 10.9 0.8 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SieB PF14163.1 CDF92072.1 - 0.11 12.1 0.1 0.17 11.4 0.1 1.3 1 0 0 1 1 1 0 Superinfection exclusion protein B DUP PF00674.13 CDF92073.1 - 5.1e-08 32.8 0.8 5.1e-08 32.8 0.6 2.0 2 0 0 2 2 2 1 DUP family Fungal_trans PF04082.13 CDF92074.1 - 5.7e-53 179.4 5.1 8.5e-53 178.8 3.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.11 CDF92075.1 - 6.4e-32 110.6 19.1 7.9e-32 110.3 13.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Arylsulfotran_2 PF14269.1 CDF92081.1 - 9.3e-71 238.4 2.4 1.3e-70 237.8 1.7 1.1 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.6 CDF92081.1 - 2.2e-14 52.8 1.9 6.4e-14 51.3 1.3 1.6 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) MFS_1 PF07690.11 CDF92082.1 - 1.3e-20 73.4 14.1 2.2e-20 72.6 9.8 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4500 PF14937.1 CDF92082.1 - 0.071 12.9 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4500) SdpI PF13630.1 CDF92082.1 - 0.75 9.5 8.5 1.6 8.5 0.9 3.2 3 0 0 3 3 3 0 SdpI/YhfL protein family Aldo_ket_red PF00248.16 CDF92084.1 - 3.1e-61 206.6 0.1 3.6e-61 206.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family T4_Gp59_C PF08994.5 CDF92084.1 - 0.022 14.9 0.1 0.048 13.8 0.1 1.5 1 0 0 1 1 1 0 T4 gene Gp59 loader of gp41 DNA helicase C-term FAD-oxidase_C PF02913.14 CDF92085.1 - 2e-50 171.4 0.0 2.8e-50 170.9 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 CDF92085.1 - 3e-36 123.9 0.0 5.8e-36 123.0 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain TPP_enzyme_N PF02776.13 CDF92087.1 - 1.1e-20 73.8 0.1 1.1e-20 73.7 0.1 1.0 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain FMN_dh PF01070.13 CDF92088.1 - 5.6e-114 380.7 0.0 6.8e-114 380.4 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.20 CDF92088.1 - 0.00013 21.0 1.2 0.0002 20.3 0.8 1.2 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.12 CDF92088.1 - 0.00037 19.5 0.1 0.00055 18.9 0.1 1.1 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.10 CDF92088.1 - 0.0004 19.6 0.2 0.00061 19.0 0.1 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase ThiG PF05690.9 CDF92088.1 - 0.00088 18.4 0.9 0.31 10.0 0.3 2.2 1 1 1 2 2 2 2 Thiazole biosynthesis protein ThiG His_biosynth PF00977.16 CDF92088.1 - 0.017 14.3 0.5 0.1 11.8 0.2 2.1 1 1 1 2 2 2 0 Histidine biosynthesis protein DHO_dh PF01180.16 CDF92088.1 - 0.088 11.7 1.3 0.31 9.9 0.3 1.9 1 1 1 2 2 2 0 Dihydroorotate dehydrogenase MFS_1 PF07690.11 CDF92090.1 - 5.6e-27 94.3 24.1 2.4e-26 92.2 15.5 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF1228 PF06779.9 CDF92090.1 - 0.00087 19.2 5.8 0.29 11.1 0.3 2.9 2 1 0 2 2 2 2 Protein of unknown function (DUF1228) Aa_trans PF01490.13 CDF92096.1 - 1e-25 90.0 30.2 2.9e-25 88.6 21.0 1.6 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein DUP PF00674.13 CDF92097.1 - 9e-08 32.0 0.1 1.9e-07 30.9 0.1 1.5 1 0 0 1 1 1 1 DUP family TPP_enzyme_N PF02776.13 CDF92100.1 - 6.1e-35 120.2 0.0 6.1e-34 116.9 0.0 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.17 CDF92100.1 - 3.5e-23 81.8 0.0 7.4e-23 80.8 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.16 CDF92100.1 - 4e-23 81.6 2.1 4.6e-21 74.9 0.1 3.9 3 2 0 4 4 4 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain